DOCSLIB.ORG

What Do My Kidneys Do

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

Artificial Organs Outcomes: Students will be expected to: • Provide examples of scientific knowledge that have resulted in the development of technologies (111-1) • Describe how a community’s needs can lead to developments in science and technology (112-2) • Make informed decisions about applications of science and technology, taking into account environmental and social advantages and disadvantages (113-9) • Propose a course of action on social issues related to science and technology, taking into account human and environmental needs (113-13) Introduction We live in an “artificial age”. Our homes are kidney, larynx, liver, lung, pancreas, and filled with artificial light, artificial wood, skin. This module will focus on the artificial artificial plants and artificial scents. We kidney as an example of artificial organ drink beverages and eat snacks sweetened technology. The functions of the natural and with artificial sweeteners, colored with artificial kidney will be investigated as well artificial colorants, and flavored with artificial as the science behind them. flavorings. We play mini-golf on artificial grass. Some people even alter their appearance with artificial nails, colored What does your Kidney do? contacts, false eye lashes, and artificial hair color. Each of these products was Your kidneys are two-bean shaped organs, developed through the application of located on either side of your spine, just technology and problem solving to everyday above the small of your back. As you will life. In the area of medicine, this application learn in this module, the kidneys are linked has led to the development of artificial directly with the circulatory and excretory organs or parts. systems. The functions of these complex organs are Organs are natural parts or structures in to clean your our body, such as our heart, lungs and blood of kidneys, which are capable of performing toxins and some special function. The presence and regulate the proper functioning of these organs is amounts of essential to our life and well-being. If these other organs become damaged or diseased we substances may experience poor health or even death. dissolved in In some situations, the use of an artificial blood. organ can assist or replace a damaged or diseased organ. This may improve an individual’s quality of life and possibly their chance of survival. The kidney: A wide variety of artificial organs and parts • removes metabolic wastes like urea and are currently available for use or at various uric acid from your blood. If not stages of development. This list includes removed these wastes would the eye, ear (cochlear implants), heart, accumulate and damage your body. • removes substances such as drugs, pesticides, food additives and other toxic substances from your blood. • keeps the concentrations of ions like potassium, calcium and sodium, and other substances in your blood at the correct levels. • maintains the proper volume of water in your body. • assists in maintaining your blood pH at the proper level. How does your kidney work? Your entire blood volume gets cleaned 20- 25 times a day. The actual cleaning occurs in tiny units inside your kidney called nephrons. Each kidney Nephron in relation to kidney. Nephron: the functional contains approximately unit of the kidney; it is 1 million nephrons. responsible for the glucose and other small molecules are able actual filtration and Blood containing purification of the blood. wastes from the body to pass through the wall into the tubule. enters the nephron Larger substances like red and white Blood plasma: is the liquid in through a knot of small blood vessels that which the blood cells are blood cells can not suspended. It makes up about pass through the wall 55% of the total blood volume. and remain in the Plasma is mainly water which has proteins, glucose, minerals Glomerulus blood. While the filtrate in the tubule and hormones dissolved in it. contains wastes and unwanted substances it also contains substances that your body can Blood vessels still use. are surrounded by a structure called the The tubule of the nephron is surrounded by glomerulus. tiny blood vessels, called capillaries. By a process called diffusion, substances that These blood vessels are under pressure and your body can still use get reabsorbed. The are against the wall of the glomerulus. The filtrate within the tubule of the nephron wall of the glomerulus is a semi-permeable contains water, ions, glucose and other membrane and acts as a filter. Certain useful small molecules substances are able to pass through, or at high concentrations. Diffusion occurs when there is a permeate the membrane. These The filtered blood in the higher concentration of a substances are referred to as the filtrate. dissolved substance on one side capillaries contains of a semi-permeable membrane these useful substances than on the other. Particles of Other substances can not pass through the at low concentrations. the dissolved substance will membrane and are filtered out. A good As a result, these useful move from the more analogy would be straining cooked pasta substances in the tubule concentrated side across the through a colander. The colander functions membrane to the less diffuse back into the concentrated side until the like a semi-permeable membrane. It capillaries. The amount concentration on both sides is captures the cooked pasta but allows the of each substance that the same. water and dissolved substances to pass is reabsorbed is through as a filtrate. controlled to maintain the perfect concentrations in the blood In the nephron, when blood containing stream. Excess material that is not waste is forced against the wall of the reabsorbed remains in the tubule where it is glomerulus, blood plasma, wastes, water, swept away with wastes and other toxic ions like potassium, calcium and sodium, substances to form urine. Urine is stored in To get your blood into the dialysis machine, the bladder and is ultimately excreted from doctors perform minor surgery, usually to the body. your arm, to make an access point into your blood stream. A needle is inserted into the Through the processes of filtration and access allowing your blood to travel outside diffusion your kidney cleans your blood, your body into the dialysis machine. The controls its composition, and maintains an artificial kidney, a component of the dialysis ideal concentration of substances in the machine, contains two parts, one for your blood. blood and one for a sterile washing fluid called the dialysate. The two fluids are What is kidney failure? separated by a thin, semi-permeable membrane. The membrane has tiny, If your kidneys become damaged or microscopic pores that act as a filter in the diseased they do not function as they same way it does in the nephron. Most normally would. blood components are able to permeate the Did you know? Wastes, other toxic membrane but larger blood cells and High blood pressure can substances, and proteins are filtered out. damage the kidney by water accumulate in breaking the tiny arteries that your blood and the feed the nephron. If these arteries break, the nephron is proper concentration unable to perform its function. of ions and other How does the artificial kidney Untreated high blood pressure substances is not work? can result in the breaking of maintained. This arteries in many nephrons. Dialysis treatments are usually performed The greater the number of inability of your three times a week and takes about four nephrons that become active, kidneys to function hours to complete. During this four hour the less efficient the kidneys properly is called period, your blood and fresh dialysate are are in cleaning the blood, and kidney failure. kidney failure can result. continuously flowing through the artificial Kidney failure is a kidney. As the two fluids flow on opposite serious health sides of the semi-permeable membrane concern which, if left untreated, may cause substances diffuse back and forth between death within days or weeks. them. The dialysate contains the ideal concentration of water, ions, glucose and other important substances found in blood. What is kidney dialysis? During dialysis, these substances will diffuse If kidney function falls below 10 to 15 across the membrane from the more percent, the use of an artificial kidney to concentrated fluid to the less concentrated assist the damaged or diseased organ may fluid until the concentration is the same in be necessary. The process of using artificial both fluids. The continuous use of fresh technology to clean your blood is called dialysate ensures that your blood achieves kidney dialysis. Kidney dialysis performs the the proper concentration of these important functions of a normal kidney by passing your substances. blood through an artificial kidney, or dialyzer. The dialysate contains many of the important substances found in blood and does not contain urea, uric acid or other wastes. As a result, wastes that have accumulated in the blood will diffuse across the membrane into the dialysate. These wastes are then carried away by the flow of the dialysate and forms a substance similar to urine which is flushed away. Conclusion and the means by which they are able to continue to live a happy and fruitful life. The artificial kidney is an example of the current use of artificial organs in medical Whatever the use, artificial organ technology science. Researchers are trying to develop has the potential to improve quality of life a wearable dialysis machine or “artificial and provide patients a greater chance of kidney”. While this machine does not yet survival. As technology continues to exist, recent advances in nanotechnology improve, artificial organ technology improves offer great potential to develop a small, as well. Perhaps one day every human wearable pack that contains tubes and organ will be able to be replaced with an membranes to filter a person’s blood.
Recommended publications
  • Te2, Part Iii

    Te2, Part Iii

    TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS
  • Kidney, Renal Tubule – Dilation

    Kidney, Renal Tubule – Dilation

    Kidney, Renal Tubule – Dilation Figure Legend: Figure 1 Kidney, Renal tubule - Dilation in a male B6C3F1 mouse from a chronic study. Dilated tubules are noted as tracts running through the cortex and outer medulla. Figure 2 Kidney, Renal tubule - Dilation in a male F344/N rat from a chronic study. Tubule dilation is present throughout the outer stripe of the outer medulla, extending into the cortex. Figure 3 Kidney, Renal tubule - Dilation in a male B6C3F1 mouse from a chronic study. Slight tubule dilation is associated with degeneration and necrosis. Figure 4 Kidney, Renal tubule - Dilation in a male F344/N rat from a chronic study. Tubule dilation is associated with chronic progressive nephropathy. Comment: Renal tubule dilation may occur anywhere along the nephron or collecting duct system. It may occur in focal areas or as tracts running along the entire length of kidney sections (Figure 1). 1 Kidney, Renal Tubule – Dilation Renal tubule dilation may occur from xenobiotic administration, secondary mechanisms, or an unknown pathogenesis (see Kidney – Nephropathy, Obstructive (Figure 2). Dilation may result from direct toxic injury to the tubule epithelium interfering with absorption and secretion (Figure 3). It may also occur secondary to renal ischemia or from prolonged diuresis related to drug administration. Secondary mechanisms of tubule dilation may result from lower urinary tract obstruction, the deposition of tubule crystals, interstitial inflammation and/or fibrosis, and chronic progressive nephropathy (Figure 4). A few dilated tubules may be regarded as normal histologic variation. Recommendation: Renal tubule dilation should be diagnosed and given a severity grade. The location of tubule dilation should be included in the diagnosis as a site modifier.
  • Excretory Products and Their Elimination

    Excretory Products and Their Elimination

    290 BIOLOGY CHAPTER 19 EXCRETORY PRODUCTS AND THEIR ELIMINATION 19.1 Human Animals accumulate ammonia, urea, uric acid, carbon dioxide, water Excretory and ions like Na+, K+, Cl–, phosphate, sulphate, etc., either by metabolic System activities or by other means like excess ingestion. These substances have to be removed totally or partially. In this chapter, you will learn the 19.2 Urine Formation mechanisms of elimination of these substances with special emphasis on 19.3 Function of the common nitrogenous wastes. Ammonia, urea and uric acid are the major Tubules forms of nitrogenous wastes excreted by the animals. Ammonia is the most toxic form and requires large amount of water for its elimination, 19.4 Mechanism of whereas uric acid, being the least toxic, can be removed with a minimum Concentration of loss of water. the Filtrate The process of excreting ammonia is Ammonotelism. Many bony fishes, 19.5 Regulation of aquatic amphibians and aquatic insects are ammonotelic in nature. Kidney Function Ammonia, as it is readily soluble, is generally excreted by diffusion across 19.6 Micturition body surfaces or through gill surfaces (in fish) as ammonium ions. Kidneys do not play any significant role in its removal. Terrestrial adaptation 19.7 Role of other necessitated the production of lesser toxic nitrogenous wastes like urea Organs in and uric acid for conservation of water. Mammals, many terrestrial Excretion amphibians and marine fishes mainly excrete urea and are called ureotelic 19.8 Disorders of the animals. Ammonia produced by metabolism is converted into urea in the Excretory liver of these animals and released into the blood which is filtered and System excreted out by the kidneys.
  • Claudins in the Renal Collecting Duct

    Claudins in the Renal Collecting Duct

    International Journal of Molecular Sciences Review Claudins in the Renal Collecting Duct Janna Leiz 1,2 and Kai M. Schmidt-Ott 1,2,3,* 1 Department of Nephrology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany; [email protected] 2 Molecular and Translational Kidney Research, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany 3 Berlin Institute of Health (BIH), 10178 Berlin, Germany * Correspondence: [email protected]; Tel.: +49-(0)30-450614671 Received: 22 October 2019; Accepted: 20 December 2019; Published: 28 December 2019 Abstract: The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis. The collecting duct epithelium is comprised of a tight epithelial barrier resulting in a strict separation of intraluminal urine and the interstitium. Tight junctions are key players in enforcing this barrier and in regulating paracellular transport of solutes across the epithelium. The features of tight junctions across different epithelia are strongly determined by their molecular composition. Claudins are particularly important structural components of tight junctions because they confer barrier and transport properties. In the collecting duct, a specific set of claudins (Cldn-3, Cldn-4, Cldn-7, Cldn-8) is expressed, and each of these claudins has been implicated in mediating aspects of the specific properties of its tight junction. The functional disruption of individual claudins or of the overall barrier function results in defects of blood pressure and water homeostasis. In this concise review, we provide an overview of the current knowledge on the role of the collecting duct epithelial barrier and of claudins in collecting duct function and pathophysiology.
  • Kidney Function • Filtration • Reabsorption • Secretion • Excretion • Micturition

    Kidney Function • Filtration • Reabsorption • Secretion • Excretion • Micturition

    About This Chapter • Functions of the kidneys • Anatomy of the urinary system • Overview of kidney function • Filtration • Reabsorption • Secretion • Excretion • Micturition © 2016 Pearson Education, Inc. Functions of the Kidneys • Regulation of extracellular fluid volume and blood pressure • Regulation of osmolarity • Maintenance of ion balance • Homeostatic regulation of pH • Excretion of wastes • Production of hormones © 2016 Pearson Education, Inc. Anatomy of the Urinary System • Kidneys, ureters, bladder, and urethra • Kidneys – Bean-shaped organ – Cortex and medulla © 2016 Pearson Education, Inc. Anatomy of the Urinary System • Functional unit is the nephron – Glomerulus in the Bowman’s capsule – Proximal tubule – The loop of Henle • Descending limb and ascending limb twisted between arterioles forming the juxtaglomerular apparatus – Distal tubule – Collecting ducts © 2016 Pearson Education, Inc. Figure 19.1b Anatomy summary The kidneys are located retroperitoneally at the level of the lower ribs. Inferior Diaphragm vena cava Aorta Left adrenal gland Left kidney Right kidney Renal artery Renal vein Ureter Peritoneum Urinary Rectum (cut) bladder (cut) © 2016 Pearson Education, Inc. Figure 19.1c Anatomy summary © 2016 Pearson Education, Inc. Figure 19.1d Anatomy summary © 2016 Pearson Education, Inc. Figure 19.1f-h Anatomy summary Some nephrons dip deep into the medulla. One nephron has two arterioles and two sets of capillaries that form a portal system. Efferent arteriole Arterioles Peritubular Juxtaglomerular capillaries The cortex apparatus contains all Bowman’s Nephrons Afferent capsules, arteriole Glomerulus proximal Juxtamedullary nephron and distal (capillaries) with vasa recta tubules. Peritubular capillaries Glomerulus The medulla contains loops of Henle and Vasa recta collecting ducts. Collecting duct Loop of Henle © 2016 Pearson Education, Inc.
  • Nomina Histologica Veterinaria, First Edition

    Nomina Histologica Veterinaria, First Edition

    NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria.
  • The Urinary System Dr

    The Urinary System Dr

    The urinary System Dr. Ali Ebneshahidi Functions of the Urinary System • Excretion – removal of waste material from the blood plasma and the disposal of this waste in the urine. • Elimination – removal of waste from other organ systems - from digestive system – undigested food, water, salt, ions, and drugs. + - from respiratory system – CO2,H , water, toxins. - from skin – water, NaCl, nitrogenous wastes (urea , uric acid, ammonia, creatinine). • Water balance -- kidney tubules regulate water reabsorption and urine concentration. • regulation of PH, volume, and composition of body fluids. • production of Erythropoietin for hematopoieseis, and renin for blood pressure regulation. Anatomy of the Urinary System Gross anatomy: • kidneys – a pair of bean – shaped organs located retroperitoneally, responsible for blood filtering and urine formation. • Renal capsule – a layer of fibrous connective tissue covering the kidneys. • Renal cortex – outer region of the kidneys where most nephrons is located. • Renal medulla – inner region of the kidneys where some nephrons is located, also where urine is collected to be excreted outward. • Renal calyx – duct – like sections of renal medulla for collecting urine from nephrons and direct urine into renal pelvis. • Renal pyramid – connective tissues in the renal medulla binding various structures together. • Renal pelvis – central urine collecting area of renal medulla. • Hilum (or hilus) – concave notch of kidneys where renal artery, renal vein, urethra, nerves, and lymphatic vessels converge. • Ureter – a tubule that transport urine (mainly by peristalsis) from the kidney to the urinary bladder. • Urinary bladder – a spherical storage organ that contains up to 400 ml of urine. • Urethra – a tubule that excretes urine out of the urinary bladder to the outside, through the urethral orifice.
  • Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

    Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

    BASIC RESEARCH www.jasn.org Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury Jun-Jae Chung ,1 Leonard Goldstein ,2 Ying-Jiun J. Chen,2 Jiyeon Lee ,1 Joshua D. Webster,3 Merone Roose-Girma,2 Sharad C. Paudyal,4 Zora Modrusan,2 Anwesha Dey,5 and Andrey S. Shaw1 Due to the number of contributing authors, the affiliations are listed at the end of this article. ABSTRACT Background The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without therapeutic options. Single-cell transcriptomics has radically improved our ability to characterize complex organs, such as the kidney. Cells of the glomerulus, however, have been largely underrepresented in previous single-cell kidney studies due to their paucity and intractability. Methods Single-cell RNA sequencing comprehensively characterized the types of cells in the glomerulus from healthy mice and from four different disease models (nephrotoxic serum nephritis, diabetes, doxo- rubicin toxicity, and CD2AP deficiency). Results Allcelltypesintheglomeruluswereidentified using unsupervised clustering analysis. Novel marker genes and gene signatures of mesangial cells, vascular smooth muscle cells of the afferent and efferent arteri- oles, parietal epithelial cells, and three types of endothelial cells were identified. Analysis of the disease models revealed cell type–specific and injury type–specific responses in the glomerulus, including acute activation of the Hippo pathway in podocytes after nephrotoxic immune injury. Conditional deletion of YAP or TAZ resulted in more severe and prolonged proteinuria in response to injury, as well as worse glomerulosclerosis.
  • Laboratory 8 - Urinary and Reproductive Systems

    Laboratory 8 - Urinary and Reproductive Systems

    Laboratory 8 - Urinary and Reproductive Systems Urinary System Please read before starting: It is easy to damage the structures of the reproductive system as you expose structures associated with excretion, so exercise caution as you do this. Please also note that we will have drawings available as well to help you find and identify the structures described below. The major blood vessels serving the kidneys are the Renal renal artery and the renal pyramid vein., which are located deep in the parietal peritoneum. The renal artery is a branch of the dorsal aorta that comes off Renal further caudal than the cranial pelvis mesenteric artery. Dissect the left kidney in situ, dividing it into dorsal and ventral portions by making a frontal section along the outer periphery. Observe the renal cortex renal medulla (next layer in) renal pyramids renal pelvis ureter (see above diagram) The kidneys include a variety of structures including an arterial supply, a venous return, extensive capillary networks around each nephron and then, of course, the filtration and reabsorption apparatus. These structures are primarily composed of nephrons (the basic functional unit of the kidney) and the ducts which carry urine away from the nephron (the collecting ducts and larger ducts eventually draining these into the ureters from each kidney. The renal pyramids contain the extensions of the nephrons into the renal medulla (the Loops of Henle) and the collecting ducts. Urine is eventually emptied into the renal pelvis before leaving the kidneys in the ureters. The ureters leaves the kidneys medially at approximately the midpoint of the organs and then run caudal to the urinary bladder.
  • Urinary System

    Urinary System

    Urinary System Urinary System Urinary System - Overview: Major Functions: 1) Removal of organic waste products Kidney from fluids (excretion) 2) Discharge of waste products into the environment (elimination) 1 3) Regulation of the volume / [solute] / pH 3 of blood plasma Ureter HOWEVER, THE KIDNEY AIN’T JUST FOR PEE’IN… Urinary bladder • Regulation of blood volume / blood pressure (e.g., renin) • Regulation of red blood cell formation (i.e., erythropoietin) 2 • Metabolization of vitamin D to active form (Ca++ uptake) Urethra • Gluconeogenesis during prolonged fasting Marieb & Hoehn (Human Anatomy and Physiology, 8th ed.) – Figure 25.1 1 Urinary System Renal ptosis: Kidneys drop to lower position due Functional Anatomy - Kidney: to loss of perirenal fat Located in the superior lumbar “Bar of soap” region 12 cm x 6 cm x 3 cm 150 g / kidney Layers of Supportive Tissue: Renal fascia: Peritoneal cavity Outer layer of dense fibrous connective tissue; anchors kidney in place Perirenal fat capsule: Fatty mass surrounding kidney; cushions kidney against blows Fibrous capsule: Transparent capsule on kidney; prevents infection of kidney from local tissues Kidneys are located retroperitoneal Marieb & Hoehn (Human Anatomy and Physiology, 8th ed.) – Figure 25.2 Urinary System Functional Anatomy - Kidney: Pyelonephritis: Inflammation of the kidney Pyramids appear striped due to parallel arrangement of capillaries / collecting tubes Renal cortex Renal medulla Renal pyramids Renal papilla Renal columns Renal hilum Renal pelvis • Entrance for blood vessels
  • Urinary System A&P

    Urinary System A&P

    URINARY SYSTEM A&P HS1 DHO8, CH. 7, PGS 217-220 OBJECTIVES EXPLAIN THE STRUCTURES AND FUNCTIONS OF THE URINARY SYSTEM AS THEY RELATE TO THE FORMATION, COMPOSITION, AND ELIMINATION OF URINE. A. IDENTIFY THE STRUCTURES COMPRISING THE URINARY SYSTEM. B. DESCRIBE THE ROLES OF EACH OF THE URINARY STRUCTURES AS IT RELATES TO THE PRODUCTION AND ELIMINATION OF URINE. URINARY SYSTEM • AKA EXCRETORY SYSTEM • REMOVES WASTES & EXCESS WATER • MAINTAIN ACID-BASE BALANCE • HELPS MAINTAIN BODY’S HOMEOSTASIS URINARY SYSTEM PARTS OF THE URINARY SYSTEM: ➢2 KIDNEYS ➢2 URETERS ➢1 BLADDER ➢1 URETHRA KIDNEYS • BEAN-SHAPED ORGANS • FOUND ON EITHER SIDE OF VERTEBRAL COLUMN • LOCATED IN RETROPERITONEAL SPACE • RETROPERITONEAL SPACE=AREA BEHIND UPPER PART OF ABD CAVITY; SEPARATED FROM ABD CAVITY BY PERITONEAL MEMBRANE KIDNEYS • PROTECTED BY RIBS & FAT CUSHION • HELD IN PLACE BY CONNECTIVE TISSUE • EACH KIDNEY IS ENCLOSED IN MASS OF FATTY TISSUE=ADIPOSE CAPSULE • EACH KIDNEY IS COVERED BY A TOUGH, FIBROUS TISSUE=RENAL FASCIA OR FIBROUS CAPSULE APPLY YOUR KNOWLEDGE CAN YOU THINK OF AN EXAMPLE OF THE URINARY SYSTEM’S ABILITY TO MAINTAIN HOMEOSTASIS? ➢A GOOD EXAMPLE IS WHEN A PERSON DRINKS A LARGE AMOUNT OF WATER AND URINARY OUTPUT INCREASES KIDNEYS DIVIDED INTO 2 MAIN SECTIONS: CORTEX & MEDULLA ➢CORTEX= • OUTER SECTION • CONTAINS MOST OF THE NEPHRONS (NEPHRONS AID IN PRODUCTION OF URINE) KIDNEYS ➢MEDULLA= • INNER SECTION • CONTAINS MOST OF THE COLLECTING TUBULES (COLLECTING TUBULES CARRY URINE FROM NEPHRONS THROUGH THE KIDNEY) KIDNEYS • EACH KIDNEY HAS A HILUM • HILUM=NOTCHED OR INDENTED AREA • THE URETER, NERVES, BLOOD VESSELS, & LYMPH VESSELS ENTER & LEAVE THE KIDNEY THROUGH THE HILUM TEST YOUR KNOWLEDGE SO, LET’S THINK THIS THROUGH….YOU HAVE TO PRODUCE THE URINE FIRST AND THEN SEND THE URINE OUT OF THE KIDNEY.
  • A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

    A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

    RAPID COMMUNICATION www.jasn.org A Single-Cell Transcriptome Atlas of the Mouse Glomerulus Nikos Karaiskos,1 Mahdieh Rahmatollahi,2 Anastasiya Boltengagen,1 Haiyue Liu,1 Martin Hoehne ,2 Markus Rinschen,2,3 Bernhard Schermer,2,4,5 Thomas Benzing,2,4,5 Nikolaus Rajewsky,1 Christine Kocks ,1 Martin Kann,2 and Roman-Ulrich Müller 2,4,5 Due to the number of contributing authors, the affiliations are listed at the end of this article. ABSTRACT Background Three different cell types constitute the glomerular filter: mesangial depending on cell location relative to the cells, endothelial cells, and podocytes. However, to what extent cellular heteroge- glomerular vascular pole.3 Because BP ad- neity exists within healthy glomerular cell populations remains unknown. aptation and mechanoadaptation of glo- merular cells are key determinants of kidney Methods We used nanodroplet-based highly parallel transcriptional profiling to function and dysregulated in kidney disease, characterize the cellular content of purified wild-type mouse glomeruli. we tested whether glomerular cell type sub- Results Unsupervised clustering of nearly 13,000 single-cell transcriptomes identi- sets can be identified by single-cell RNA fied the three known glomerular cell types. We provide a comprehensive online sequencing in wild-type glomeruli. This atlas of gene expression in glomerular cells that can be queried and visualized using technique allows for high-throughput tran- an interactive and freely available database. Novel marker genes for all glomerular scriptome profiling of individual cells and is cell types were identified and supported by immunohistochemistry images particularly suitable for identifying novel obtained from the Human Protein Atlas.