gene.id fc1 fc2 fc3 fc4 p1 p2 p3 p4 FDR.pvalue-1 Gene Symbol Gene Title Pathway go biological process term go molecular function term go cellular component term Dr.10016.1.A1_at -2.33397 -3.86923 -4.38335 -2.39965 0.935201 0.320614 0.208 0.917227 0.208 zgc:77556 zgc:77556 --- proteolysis arylesterase activity /// metallopeptidase activity /// zinc ion --- binding Dr.10024.1.A1 at 1.483417 2.531269 2.089091 1.698761 1 0.613 0.998961 1 0.613 zgc:171808 zgc:171808--- cell-cell signaling ------Dr.10051.1.A1 at -1.78449 -2.22024 -1.70922 -1.99464 1 0.901663 1 0.999955 0.9017 ccng2 cyclin G2 ------Dr.10061.1.A1 at 2.065955 2.274632 2.248958 2.507754 0.992 0.718655 0.83 0.600609 0.6006 zgc:173506 zgc:173506------Dr.10061.2.A1 at 2.131883 2.616483 2.49378 2.815337 0.983443 0.711513 0.805599 0.519115 0.5191 zgc:173506 Zgc:17350 ------Dr.10065.1.A1 at -1.02315 -2.01596 -2.29343 -1.88944 1 0.999955 0.957199 1 0.9572 zgc:114139 zgc:114139------cytoplasm /// centrosome Dr.10070.1.A1_at -1.74365 -2.52206 -2.39093 -1.86817 1 0.741254 0.885401 1 0.7413 fbp1a fructose-1, --- carbohydrate metabolic process activity /// phosphoric ester hydrolase activity ---

Dr.10074.1.S1_at 6.035545 10.44051 7.880519 5.020371 0.1104 0.044 0.062491 0.144679 0.044 pdgfaa platelet-der--- multicellular organismal development /// cell proliferation growth factor activity membrane

Dr.10095.1.A1 at -1.73408 -2.11615 -1.47234 -2.19919 1 0.997562 1 0.978177 0.9782 wu:fk95g04 wu:fk95g04------Dr.10110.1.S1 a at 3.929761 5.798708 5.169868 4.287609 0.107354 0.05204 0.054437 0.09638 0.052 polr2e polymerase --- transcription DNA binding /// DNA-directed RNA polymerase activity nucleus Dr.10113.1.S1 at 1.534276 2.388769 2.301388 1.738762 1 0.512 0.528714 1 0.512 cox17 COX17 cyt--- copper ion transport /// response to copper ion copper ion binding /// copper chaperone activity mitochondrial intermembrane space Dr.1012.1.A1_at 2.583237 3.376769 2.525655 1.291251 0.515302 0.030277 0.655742 1 0.0303 rdh10 retinol dehy--- metabolic process /// oxidation reduction catalytic activity /// binding /// activity endoplasmic reticulum /// endoplasmic reticulum membrane /// microsome /// membrane /// integral to membrane Dr.10128.1.A1 at 11.17399 12.61297 9.043752 5.751042 0.014232 0.005396 0.009102 0.014808 0.0054 wu:fl02d04 wu:fl02d04 ------Dr.10130.1.S1_at 6.514092 9.031304 6.699579 4.921642 0.10836 0.06 0.109801 0.196936 0.06 zgc:158347 zgc:158347--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.10130.2.A1_at 7.537452 9.562842 7.143264 5.550622 0.012039 0.009117 0.01711 0.023606 0.0091 zgc:158347 zgc:158347--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.10133.1.A1_at 2.113735 2.747846 3.178364 2.907277 0.998 0.741417 0.253759 0.324797 0.2538 zgc:110766 zgc:110766--- translational elongation binding /// translation activity /// intracellular GTPase activity /// GTP binding Dr.10134.1.A1 at 2.188854 2.226798 1.778405 2.649883 0.543861 0.206064 1 0.189422 0.1894 wu:fl04a11 wu:fl04a11 ------Dr.10136.1.S1 at -1.49458 -4.22971 -5.0075 -4.29185 1 0.070127 0.038858 0.060321 0.0389 gng3 guanine nu--- G-protein coupled receptor protein signaling pathway signal transducer activity heterotrimeric G-protein complex Dr.10136.2.S1 at -1.04946 1.428918 1.863026 2.409468 1 1 1 0.5156 0.5156 arpc3 actin relate--- regulation of actin filament polymerization --- cytoskeleton Dr.10136.3.S1 at -1.10859 -2.28412 -2.68993 -2.23508 1 0.923513 0.30862 0.94396 0.3086 gng3 Guanine nu--- G-protein coupled receptor protein signaling pathway signal transducer activity heterotrimeric G-protein complex Dr.10145.1.A1 at -1.58865 -1.9279 -2.40126 -1.86824 1 1 0.940843 1 0.9408 zgc:110003 zgc:110003------Dr.10183.1.S2_at 1.000405 1.094791 -1.56038 -2.34767 1 1 1 0.539 0.539 egr1 early growt--- transcription /// transcription termination /// regulation of nucleic acid binding /// DNA binding /// zinc ion binding /// intracellular /// nucleus transcription, DNA-dependent /// zinc ion transport /// metal ion binding transcription antitermination /// camera-type eye development Dr.10185.1.S1 at -1.16511 1.660278 2.634722 5.412993 1 1 0.117655 0.036906 0.0369 LOC563089 similar to T ------Dr.1019.1.A1 at 1.014781 1.044491 1.568317 2.168727 1 1 1 0.798838 0.7988 wu:fi38h09 wu:fi38h09 ------Dr.10198.1.S1_at 2.553732 4.440244 3.549832 2.976786 0.899446 0.043186 0.117331 0.240942 0.0432 atp1b1a ATPase, N--- transport /// ion transport /// potassium ion transport /// potassium channel activity /// sodium channel activity /// membrane /// integral to membrane sodium ion transport sodium:potassium-exchanging ATPase activity /// potassium channel inhibitor activity /// sodium channel inhibitor activity /// potassium ion binding /// sodium ion binding

Dr.10198.1.S2_at 1.744859 2.56902 2.109804 1.792478 1 0.669435 0.997322 1 0.6694 atp1b1a ATPase, N--- transport /// ion transport /// potassium ion transport /// potassium channel activity /// sodium channel activity /// membrane /// integral to membrane sodium ion transport sodium:potassium-exchanging ATPase activity /// potassium channel inhibitor activity /// sodium channel inhibitor activity /// potassium ion binding /// sodium ion binding

Dr.10199.1.S1 at -2.76996 -2.55994 -2.32918 -2.21314 0.740775 0.236099 0.441493 0.889137 0.2361 tob1b transducer ------Dr.10201.1.S1 at 1.150959 1.336467 1.53946 2.810718 1 1 1 0.18 0.18 sepw1 selenoprote--- cell redox homeostasis selenium binding cytoplasm Dr.10211.1.A1 at 1.849127 2.228291 1.215878 1.111118 1 0.850337 1 1 0.8503 zgc:92395 zgc:92395 --- intracellular signaling cascade ------Dr.10215.1.A1_at -2.9236 -2.38462 -2.70622 -1.60512 0.41 0.817646 0.423095 1 0.41 pgm1 phosphoglu--- carbohydrate metabolic process magnesium ion binding /// intramolecular activity, --- phosphotransferases /// metal ion binding Dr.10215.2.S1_at -3.26221 -2.80949 -2.30928 -2.1819 0.413275 0.183882 0.760905 0.996557 0.1839 pgm1 phosphoglu--- carbohydrate metabolic process magnesium ion binding /// intramolecular transferase activity, --- phosphotransferases /// metal ion binding Dr.10228.1.A1_at 11.00424 8.140982 9.141098 5.445649 0.009699 0.105129 0.01049 0.022262 0.0097 mych myelocytom--- regulation of transcription, DNA-dependent /// regulation of transcription factor activity /// transcription regulator activity nucleus /// nucleus transcription Dr.10241.1.S1 at 2.352238 3.293572 3.202167 4.237742 0.409 0.046521 0.008935 0.052725 0.0089 snrpd1 small nucle--- mRNA metabolic process nucleic acid binding ribonucleoprotein complex Dr.10243.1.A1 at 2.309413 3.399056 3.127051 2.96037 0.853899 0.199486 0.129698 0.127858 0.1279 ------Dr.10249.1.A1 at 1.929179 2.21917 2.406841 4.469107 1 0.995 0.853 0.16864 0.1686 ------Dr.10250.1.A1 at -6.48067 -2.88297 -3.36575 -3.05588 0.057523 0.235345 0.057191 0.115472 0.0572 tdh L-threonine --- metabolic process /// cellular metabolic process catalytic activity /// binding /// coenzyme binding --- Dr.10254.1.A1_at -2.41011 -3.02466 -2.67056 -2.50306 0.987827 0.532758 0.795773 0.896485 0.5328 lin7b lin-7 homol------nucleotide binding /// nucleic acid binding /// protein binding ribonucleoprotein complex

Dr.10261.1.S1 at 1.066537 1.483444 2.737626 2.646065 1 1 0.522548 0.532226 0.5225 zgc:85717 zgc:85717 ------calmodulin binding --- Dr.10263.1.A1 at 1.333075 1.888567 2.161868 1.890765 1 1 0.824623 1 0.8246 wu:fk51e09 wu:fk51e09------Dr.10273.1.S1 at 2.010357 2.572705 2.489719 3.735504 1 0.99 0.958901 0.598446 0.5984 si:ch211-239j9.2 si:ch211-23------cytochrome-c oxidase activity --- Dr.10279.1.S1 at 1.111236 1.292388 1.301635 2.108039 1 1 1 0.922644 0.9226 h3f3a /// h3f3c /// zgc:1102H3 histone --- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.10283.1.A1_at -1.5079 -1.80097 -2.14129 -1.61067 1 1 0.893679 1 0.8937 bnip3l BCL2/aden--- heart looping /// positive regulation of apoptosis /// positive --- mitochondrial envelope /// integral to regulation of apoptosis /// negative regulation of heart membrane contraction Dr.10290.1.A1 at 1.632623 2.817725 3.369515 3.507455 1 0.306 0.257391 0.109634 0.1096 psmd10 proteasome ------cytosol /// protein complex Dr.10293.2.S1_a_at -1.21013 -2.0026 -2.40366 -2.55915 1 0.9997 0.941539 0.861865 0.8619 LOC100004285 /// zgc:73 similar to R--- visual perception 3',5'-cyclic-nucleotide phosphodiesterase activity /// cGMP --- binding Dr.10293.2.S1_at -1.47149 -2.5369 -3.19326 -3.20139 1 0.952845 0.667637 0.716625 0.6676 LOC100004285 /// zgc:73 similar to R--- visual perception 3',5'-cyclic-nucleotide phosphodiesterase activity /// cGMP --- binding Dr.10319.1.S1_at 1.398187 2.26515 2.231869 1.678091 1 0.557441 0.632415 1 0.5574 copg2 /// DKEY-117N7.8 /coatomer p--- transport /// intracellular protein transport /// protein serine-type endopeptidase inhibitor activity /// structural Golgi membrane /// cytoplasm /// Golgi transport /// vesicle-mediated transport molecule activity /// binding /// protein binding apparatus /// Golgi-associated vesicle /// membrane /// membrane coat /// COPI vesicle coat /// cytoplasmic vesicle Dr.10320.1.S1_at 8.144383 8.48334 7.662411 5.636163 0.007778 0.005396 0.007209 0.007628 0.0054 sgk1 serum/gluc--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.10326.1.S1_at 5.795696 5.551565 4.060315 3.442971 0.051673 0.03 0.075552 0.13899 0.03 junb jun B proto --- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription specific DNA binding /// protein dimerization activity

Dr.10329.1.S1_at -1.52307 -1.78526 -1.77535 -2.77489 1 1 1 0.63608 0.6361 cry1a cryptochrom--- DNA repair /// response to light stimulus /// entrainment of DNA photolyase activity /// protein binding /// transcription nucleus /// transcription factor complex circadian clock /// response to hydrogen peroxide repressor activity

Dr.10340.1.S1_at -3.2525 -1.87294 -2.38399 -2.7036 0.853899 1 0.997562 0.975461 0.8539 per3 period hom--- regulation of transcription, DNA-dependent /// signal signal transducer activity --- transduction /// photoperiodism Dr.10345.1.A1 at 1.732641 2.427395 2.802454 1.261622 1 0.987421 0.958523 1 0.9585 wu:fb14a07 wu:fb14a07------Dr.10361.1.A1_at -1.47239 -1.4838 -1.5536 -2.0183 1 1 1 0.995 0.995 spry2 Sprouty ho--- multicellular organismal development /// dorsal/ventral --- membrane pattern formation /// dorsal/ventral pattern formation /// regulation of signal transduction /// negative regulation of fibroblast growth factor receptor signaling pathway Dr.10384.1.S1_at 1.26558 1.838143 1.928166 2.55698 1 1 1 0.084727 0.0847 ndufab1 NADH deh--- fatty acid biosynthetic process /// lipid biosynthetic process acyl carrier activity /// calcium ion binding /// --- phosphopantetheine binding /// binding Dr.10390.1.S1 at 1.219296 1.481401 2.198614 2.251345 1 1 0.579 0.937927 0.579 arpc5b actin relate--- regulation of actin filament polymerization --- cytoskeleton Dr.10393.1.A1 at -1.22825 -1.56809 -2.02768 -1.73481 1 1 0.916444 1 0.9164 ------Dr.10397.1.A1 at 1.228203 2.689006 2.650477 2.228047 1 0.663222 0.750964 0.954613 0.6632 si:ch211-258l4.7 Si:ch211-2 ------Dr.10410.1.A1_at 4.879351 5.298991 3.558712 2.572232 0.030047 0.019717 0.052564 0.342153 0.0197 zgc:158347 zgc:158347--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.10417.1.A1 at 1.319113 2.411426 2.373339 2.999997 1 0.800541 0.888257 0.316393 0.3164 tbl2 ------Dr.10424.1.A1 at 1.40693 1.466197 2.736579 2.235245 1 1 0.748 0.996552 0.748 zgc:110182 zgc:110182------Dr.1043.1.S1_at 1.537692 2.086191 2.043844 2.695885 1 0.997143 1 0.068757 0.0688 atp5g ATP syntha--- transport /// ion transport /// ATP synthesis coupled proton lipid binding /// hydrogen ion transmembrane transporter membrane /// integral to membrane /// proton- transport /// proton transport /// ATP metabolic process activity /// hydrogen ion transporting ATP synthase activity, transporting two-sector ATPase complex /// rotational mechanism /// hydrogen ion transporting ATPase proton-transporting ATP synthase complex, activity, rotational mechanism coupling factor F(o) Dr.10431.1.S1 at 32.19138 79.87114 15.28634 4.077228 0.023959 0.016252 0.080135 0.646 0.0163 ctgf connective --- regulation of cell growth insulin-like growth factor binding extracellular region Dr.1044.1.S1_at 2.73189 3.276642 3.461174 3.695353 0.303711 0.043608 0.018703 0.03646 0.0187 cyc1 cytochrome ------iron ion binding /// electron carrier activity /// heme binding ---

Dr.10442.1.A1_at -1.35979 -2.08364 -2.2339 -1.75032 1 0.930374 0.757387 1 0.7574 mkrn1 makorin, rin--- zinc ion transport nucleic acid binding /// protein binding /// zinc ion binding /// --- metal ion binding Dr.1045.1.A1 at -1.85163 -3.12103 -3.90639 -1.62373 1 0.188597 0.032425 1 0.0324 wu:fb74f10 wu:fb74f10 ------Dr.10452.2.S1_a_at 1.528048 2.192959 2.270927 3.055299 1 0.918417 0.599 0.040555 0.0406 mapk1 mitogen-ac--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// MAP kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.10461.1.S1_at 1.246191 -1.08087 -2.36948 1.570267 1 1 0.984 1 0.984 cyp19a1b cytochrome --- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// electron carrier --- iron ion homeostasis /// response to estradiol stimulus /// activity /// oxidoreductase activity /// heme binding /// metal response to estrogen stimulus /// response to steroid ion binding hormone stimulus /// oxidation reduction

Dr.10462.1.S1_at -1.46032 -1.73918 -1.37794 -2.13472 1 1 1 0.973237 0.9732 or115-14 odorant rec--- signal transduction /// G-protein coupled receptor protein rhodopsin-like receptor activity /// signal transducer activity plasma membrane /// membrane /// integral to signaling pathway /// receptor activity /// G-protein coupled receptor activity /// membrane olfactory receptor activity Dr.1047.1.S1_at -1.54857 -1.5254 1.272884 12.02462 1 1 1 0.020851 0.0209 tyms thymidylate --- dTMP biosynthetic process /// dTMP biosynthetic process thymidylate synthase activity /// thymidylate synthase activity --- /// nucleotide biosynthetic process /// retina development in /// methyltransferase activity /// transferase activity /// 5,10- camera-type eye methylenetetrahydrofolate-dependent methyltransferase activity Dr.10477.1.S1 at 1.796404 2.480136 2.560891 2.082576 1 0.968 0.718548 1 0.7185 zgc:56334 zgc:56334 ------intracellular Dr.10495.1.S1 at -1.48485 -1.97279 -2.06699 -1.84051 1 0.999955 0.975461 1 0.9755 arglu1a arginine an------Dr.1050.1.S1 at -1.65683 -1.26644 4.021335 11.27886 1 1 0.274958 0.030075 0.0301 zgc:110113 zgc:110113------Dr.1051.1.S1_at 1.53589 2.082211 2.076179 1.972037 1 0.894192 0.996879 1 0.8942 dldh dihydrolipoa--- cell redox homeostasis /// oxidation reduction dihydrolipoyl dehydrogenase activity /// electron carrier cytoplasm activity /// oxidoreductase activity /// FAD binding Dr.10511.1.A1_at -1.49519 -1.74972 -2.07998 -2.11094 1 1 0.999955 0.998 0.998 ogt O-linked N- --- protein amino acid O-linked glycosylation binding /// protein binding /// protein N- --- acetylglucosaminyltransferase activity /// transferase activity

Dr.1052.1.S1_at 1.733086 1.911668 1.977746 2.065576 1 1 1 0.997562 0.9976 zgc:110034 zgc:110034--- translation structural constituent of ribosome intracellular /// mitochondrion /// ribosome /// ribonucleoprotein complex Dr.1053.1.A1_at 3.52082 7.338406 5.222671 4.429315 0.32251 0.060175 0.111568 0.146639 0.0602 zgc:113191 zgc:113191------nucleotide binding /// translation elongation factor activity /// --- GTPase activity /// GTP binding Dr.10532.1.S1_at -3.64991 -4.60386 -3.71952 -3.41086 0.399437 0.23417 0.358158 0.56765 0.2342 map2k6 mitogen-ac--- protein amino acid phosphorylation protein kinase activity /// protein serine/threonine kinase --- activity /// ATP binding /// kinase activity Dr.1054.1.S1_at 1.607105 2.813551 3.273773 3.864693 1 0.249 0.042 0.041851 0.0419 rps14 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.10542.1.S1_at -1.13062 -1.78025 -2.2502 -3.02484 1 1 0.973 0.214132 0.2141 hsd3b7 hydroxy-de --- steroid biosynthetic process /// metabolic process /// cellular catalytic activity /// 3-beta-hydroxy-delta5-steroid --- metabolic process /// oxidation reduction dehydrogenase activity /// binding /// oxidoreductase activity /// activity /// coenzyme binding Dr.10545.1.S1 at -1.8007 -1.86163 -2.37399 -1.59126 1 1 0.749 1 0.749 rnf13 ring finger --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.1055.1.S1_at -1.1618 -1.21349 1.499648 2.374382 1 1 1 0.794705 0.7947 mcm7 MCM7 min --- DNA replication initiation nucleotide binding /// DNA binding /// ATP binding /// nucleus nucleoside-triphosphatase activity Dr.10556.1.S1 at 4.506753 5.49286 6.590517 5.470798 0.061403 0.029855 0.025874 0.038108 0.0259 dkc1 dyskeratos--- pseudouridine synthesis RNA binding /// pseudouridine synthase activity --- Dr.10563.1.S1 at 1.160473 1.798691 1.504658 2.455626 1 1 1 0.458196 0.4582 msi2 musashi ho------nucleotide binding /// nucleic acid binding --- Dr.10566.1.A1_at -1.05502 1.00645 -1.02361 4.389914 1 1 1 0.055018 0.055 zgc:66125 zgc:66125 --- microtubule-based movement nucleotide binding /// motor activity /// microtubule motor microtubule /// microtubule associated activity /// ATP binding complex Dr.1058.1.S1 at 2.375594 3.144491 3.028038 2.904508 0.158995 0.066117 0.037083 0.025788 0.0258 phb prohibitin ------membrane Dr.10580.1.S1_at -1.13035 -1.00755 1.051948 2.215538 1 1 1 0.96723 0.9672 nek2 NIMA (neve--- protein amino acid phosphorylation protein kinase activity /// protein serine/threonine kinase --- activity /// ATP binding /// kinase activity Dr.10596.1.S1_at 1.333295 2.405919 2.779949 3.921937 1 0.401553 0.261499 0.031918 0.0319 psma4 proteasome --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome activity /// endopeptidase inhibitor activity /// peptidase core complex /// protein complex activity /// hydrolase activity Dr.10624.1.S1 at 1.841823 2.167763 2.307423 2.004271 1 0.968057 0.479 0.9997 0.479 zgc:110343 zgc:110343------antioxidant activity /// oxidoreductase activity --- Dr.10624.2.S1 a at 1.637871 2.555018 2.709938 2.013862 1 0.701 0.166346 1 0.1663 zgc:110343 zgc:110343------antioxidant activity /// oxidoreductase activity --- Dr.10638.1.A1_at -1.1282 1.385613 1.693445 2.839806 1 1 1 0.653255 0.6533 LOC559749 similar to M------DNA binding /// single-stranded DNA binding /// nucleus transcription regulator activity Dr.1065.1.S1_at 1.178377 2.576889 3.446291 5.165568 1 0.271 0.034097 0.020781 0.0208 rpsa ribosomal p--- translation structural constituent of ribosome /// receptor activity intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex

Dr.10661.1.S1 at 2.315821 1.641712 1.697252 1.486554 0.828749 1 1 1 0.8287 cdc5l CDC5 cell --- regulation of transcription /// cell division DNA binding nucleus Dr.10664.1.S1 at 1.559972 2.205657 1.837367 2.089697 1 0.784 1 0.981363 0.784 cd81 CD81 antig ------membrane /// integral to membrane Dr.10666.1.S1_at -1.63284 -1.73799 -1.53315 -2.20243 1 1 1 0.83072 0.8307 hoxa11b homeo box --- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription, DNA-dependent /// multicellular organismal specific DNA binding development /// transcription antitermination /// regulation of transcription Dr.10676.1.S1_at 2.804932 3.392296 2.475292 1.276119 0.108142 0.055301 0.415552 1 0.0553 cds2 CDP-diacy--- phospholipid biosynthetic process phosphatidate cytidylyltransferase activity /// transferase membrane /// integral to membrane activity /// nucleotidyltransferase activity Dr.10676.2.S1_at 2.427811 2.804505 2.100683 1.302292 0.472548 0.196249 0.954469 1 0.1962 gabrb2 gamma-am--- transport /// ion transport /// negative regulation of signal receptor activity /// GABA-A receptor activity /// ion channel signal recognition particle, endoplasmic transduction activity /// extracellular ligand-gated ion channel activity /// reticulum targeting /// membrane /// integral to neurotransmitter receptor activity membrane /// cell junction /// synapse /// postsynaptic membrane Dr.10689.1.S1 at 1.149473 3.053916 4.310328 5.766652 1 0.168564 0.127359 0.014728 0.0147 zic2b zic family m------nucleic acid binding /// zinc ion binding intracellular Dr.10708.1.S1_at -1.26551 -1.6529 -1.38914 -2.04425 1 1 1 0.991 0.991 atp1b1b ATPase, N--- transport /// ion transport /// potassium ion transport /// potassium channel activity /// sodium channel activity /// membrane /// integral to membrane sodium ion transport sodium:potassium-exchanging ATPase activity /// potassium channel inhibitor activity /// sodium channel inhibitor activity /// potassium ion binding /// sodium ion binding

Dr.10728.1.S1 at -1.85144 -2.1765 -1.6021 -2.36674 1 0.988806 1 0.864834 0.8648 gcga glucagon a ------hormone activity extracellular region Dr.10733.1.S1_at -2.01484 -2.2049 -1.35656 -2.96167 0.99934 0.926 1 0.420201 0.4202 mafl v-maf musc--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription, DNA-dependent /// transcription specific DNA binding /// protein dimerization activity antitermination /// regulation of transcription Dr.1076.1.A1 at 2.384607 3.732215 3.215424 2.78586 0.739526 0.110859 0.244671 0.421537 0.1109 wu:fa91f10 wu:fa91f10 ------Dr.10800.1.A1 at 1.078425 2.105499 2.805589 2.071141 1 0.9997 0.410683 0.996 0.4107 ------Dr.10807.1.A1 at 1.250518 1.60835 1.855553 2.368298 1 1 1 0.629379 0.6294 LOC563517 similar to S ------Dr.1081.1.S1_at 2.992631 7.26274 7.856229 7.500616 0.204527 0.010989 0.010089 0.010912 0.0101 eef1b2 eukaryotic t--- translation /// translational elongation translation elongation factor activity eukaryotic translation elongation factor 1 complex Dr.1082.1.S1_at 3.328123 2.838678 1.409946 1.30368 0.68673 0.642 1 1 0.642 ptgs2a prostagland--- response to oxidative stress /// response to chemical peroxidase activity /// peroxidase activity /// oxidoreductase --- stimulus /// oxidation reduction activity /// heme binding Dr.10826.1.A1 at 1.794764 7.932839 4.72142 2.685265 0.999917 0.00972 0.030837 0.299111 0.0097 ------Dr.10833.1.A1_at 1.396393 1.825322 1.77492 2.160147 1 1 1 0.996244 0.9962 pak2b p21 (CDKN--- blood vessel development /// protein amino acid nucleotide binding /// protein kinase activity /// protein --- phosphorylation serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.10840.1.S1 at 1.343601 1.896315 2.65353 3.579558 1 1 0.554804 0.310378 0.3104 mapre1l microtubule------microtubule binding --- Dr.10841.1.A1 at 2.158298 2.94428 2.497211 2.343029 0.982587 0.383502 0.851 0.862801 0.3835 wu:fa18b03 wu:fa18b03------Dr.1085.1.S1 at 2.726791 4.813255 4.781501 3.935986 0.424132 0.016521 0.062073 0.087638 0.0165 zgc:110288 zgc:110288------Dr.1085.2.A1 at 5.56806 8.319325 9.746519 7.498914 0.060597 0.015143 0.017694 0.008685 0.0087 zgc:110288 zgc:110288------Dr.1089.1.S1_at -2.20047 -2.05616 -1.70468 -1.77826 0.897457 0.974166 1 1 0.8975 thbs3a thrombospo--- calcium ion transport /// cell adhesion /// cell-matrix structural molecule activity /// calcium channel activity /// extracellular region /// extracellular region /// adhesion /// negative regulation of signal transduction /// cell- calcium ion binding /// calcium ion binding /// protein binding signal recognition particle, endoplasmic cell adhesion /// heparin binding /// calcium channel inhibitor activity reticulum targeting

Dr.10904.2.S1 at -1.70385 -2.40484 -2.2333 -2.0947 1 0.965 0.996882 0.99994 0.965 add3a adducin 3 (------metal ion binding --- Dr.10904.2.S2 at -1.38912 -1.984 -2.05271 -1.54607 1 0.999955 0.98838 1 0.9884 add3a adducin 3 (------metal ion binding --- Dr.1094.1.A1 at 1.701502 2.664828 3.220434 2.734742 1 0.195143 0.064433 0.271 0.0644 wu:fk49e12 wu:fk49e12------Dr.10958.1.A1 at 1.164622 1.976717 2.147069 1.825164 1 1 0.996674 1 0.9967 zgc:162873 zgc:162873------Dr.11010.1.S1_at 7.132379 4.414031 1.596348 2.905393 0.545978 0.982446 1 0.986747 0.546 zgc:64003 zgc:64003 --- immune response /// antigen processing and presentation --- membrane /// integral to membrane /// MHC class I protein complex Dr.1102.1.S1 at 1.589163 2.202535 2.543306 2.309148 1 0.914908 0.667898 0.789958 0.6679 icat /// LOC100150468 beta-cateni ------beta-catenin binding --- Dr.11035.1.A1 at -1.33623 -2.41994 -2.95661 -1.81058 1 0.540428 0.37084 1 0.3708 wu:fj35f12 wu:fj35f12 ------Dr.11042.1.S1 at -1.05561 1.14772 1.420949 2.110065 1 1 1 0.996637 0.9966 ------Dr.11048.1.A1 at 1.270776 -1.31591 -2.5874 -2.21025 1 1 0.930314 0.949 0.9303 ------Dr.11051.1.A1 at -1.64154 -3.0293 -4.42599 -2.46737 1 0.27925 0.02717 0.088 0.0272 ------Dr.11052.2.A1_at -1.15637 -1.73657 -2.78341 -2.02771 1 1 0.740397 0.993564 0.7404 oaz2l ornithine de------ inhibitor activity /// ornithine decarboxylase inhibitor --- activity Dr.11057.1.S1 at 2.415368 1.935023 1.775077 1.460268 0.965 1 1 1 0.965 chchd10 coiled-coil- --- type I hypersensitivity ------Dr.11069.2.S1_at -1.53731 -2.01829 -1.5456 -1.87193 1 0.99994 1 1 0.9999 zgc:77752 zgc:77752 --- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein --- tyrosine/serine/threonine phosphatase activity /// hydrolase activity /// phosphatase activity Dr.11073.1.A1 at 1.217997 2.074617 1.371333 1.244301 1 0.851586 1 1 0.8516 wu:fk66a11 wu:fk66a11------Dr.11074.1.A1 at -1.55116 -1.88183 -1.55423 -2.31804 1 1 1 0.861246 0.8612 ------Dr.11074.2.A1 at -1.54892 -1.79958 -1.33598 -2.26107 1 1 1 0.786 0.786 ------Dr.11077.1.A1 at -1.75862 -2.13897 -2.13672 -2.46902 1 0.83072 0.99934 0.372043 0.372 ------Dr.11078.1.S1 at 4.55531 3.197486 2.32606 1.677751 0.235704 0.482287 0.93 1 0.2357 ------Dr.1108.1.S1_at 1.143251 1.950786 1.956258 2.463433 1 1 1 0.407741 0.4077 ddx39b DEAD (Asp------nucleic acid binding /// helicase activity /// ATP binding /// --- ATP-dependent helicase activity /// hydrolase activity

Dr.11081.1.S1_at 1.935508 2.588482 2.722176 2.668327 1 0.737 0.54646 0.520166 0.5202 mrpl23 mitochondr------nucleotide binding mitochondrion /// ribosome /// ribonucleoprotein complex Dr.11085.1.A1 at -1.98817 -2.4674 -4.11832 -3.41522 0.997562 0.179582 0.069513 0.043835 0.0438 rlbp1a retinaldehy--- transport transporter activity intracellular Dr.11086.1.A1 at 2.031733 1.747683 1.527271 1.667688 0.987421 1 1 1 0.9874 wu:fb18g03 wu:fb18g03------Dr.11095.1.A1 at -1.77611 -2.56498 -2.34932 -2.95829 1 0.399573 0.737 0.211 0.211 LOC570112 similar to s------Dr.11104.1.A1_at 1.339462 -1.56914 -2.87475 -2.521 1 1 0.693097 0.891306 0.6931 ndrg4 N-myc dow--- heart looping /// embryonic heart tube development /// phosphopantetheine binding --- cardiac muscle cell proliferation Dr.1111.1.S1_at 2.151779 2.752335 2.912719 3.261504 0.956 0.102971 0.242552 0.041808 0.0418 ddx39a DEAD (Asp------nucleic acid binding /// helicase activity /// ATP binding /// --- ATP-dependent helicase activity /// hydrolase activity

Dr.11119.1.A1 at -1.34773 -2.01129 -1.74669 -2.3876 1 0.999955 1 0.748909 0.7489 scn3b Sodium cha------ion channel activity --- Dr.11125.1.A1_at -1.37957 -1.79033 -2.00377 -2.18211 1 1 1 0.956 0.956 zgc:110344 zgc:110344--- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription specific DNA binding Dr.11132.1.A1 at 2.142733 -1.38387 -1.94219 -1.53665 0.954984 1 0.999955 1 0.955 ------Dr.11137.1.A1_at -2.12238 -4.21439 -4.71822 -2.7075 0.961627 0.07877 0.041969 0.343907 0.042 pygl phosphoryl--- carbohydrate metabolic process phosphorylase activity /// transferase activity /// transferase --- activity, transferring glycosyl groups /// pyridoxal phosphate binding Dr.11137.2.A1_a_at -1.78869 -3.56694 -4.46264 -2.2894 1 0.079569 0.029096 0.638101 0.0291 pygl phosphoryl--- carbohydrate metabolic process phosphorylase activity /// transferase activity /// transferase --- activity, transferring glycosyl groups /// pyridoxal phosphate binding Dr.11137.2.A1_x_at -1.35425 -2.10649 -2.39696 -1.66734 1 0.947726 0.451 1 0.451 pygl phosphoryl--- carbohydrate metabolic process phosphorylase activity /// transferase activity /// transferase --- activity, transferring glycosyl groups /// pyridoxal phosphate binding Dr.11149.1.A1 at -1.3347 -2.12983 -2.87129 -2.51318 1 0.996882 0.553731 0.676052 0.5537 casz1 castor zinc ------Dr.11149.2.S1 at -1.18498 -1.90405 -2.41042 -2.45109 1 1 0.943622 0.875 0.875 ------Dr.1115.1.S1 at 1.16111 2.513764 2.293925 2.748864 1 0.534 0.701 0.201713 0.2017 zgc:73269 zgc:73269 ------membrane /// integral to membrane Dr.11156.1.S1 at -1.64244 -1.76071 -1.48995 -2.31791 1 1 1 0.847 0.847 ------Dr.11161.1.A1 at 2.916111 -1.15138 -1.30828 -1.11454 0.751226 1 1 1 0.7512 samd11l sterile alph------Dr.11165.1.A1_at -1.46637 -2.08715 -1.33793 -2.06402 1 0.999325 1 0.99934 0.9993 LOC100148403 /// zgc:66 similar to d--- transport /// ion transport GABA-A receptor activity /// ion channel activity /// membrane /// integral to membrane /// cell extracellular ligand-gated ion channel activity /// junction /// synapse /// postsynaptic membrane neurotransmitter receptor activity Dr.11171.1.A1 at -1.82542 -1.75823 -2.06316 -1.83408 1 1 0.971702 1 0.9717 si:ch211-210h11.11 si:ch211-21------Dr.11177.1.A1 at -1.70088 -1.69665 -2.75102 -2.05235 1 1 0.699 0.996674 0.699 ------Dr.11178.1.A1 at 1.093105 -2.24664 -3.20535 -2.72762 1 0.985798 0.376611 0.716903 0.3766 ------Dr.11183.1.A1_at 1.471885 -2.84938 -4.17875 -3.2977 1 0.673 0.366723 0.561 0.3667 Guanylate c--- protein amino acid phosphorylation protein kinase activity /// protein tyrosine kinase activity /// --- ATP binding Dr.11187.1.A1 at -1.73598 -3.53286 -6.1647 -4.00264 1 0.475699 0.18568 0.363 0.1857 ------Dr.11188.1.A1 at -1.16615 -1.7948 -1.77058 -2.24341 1 1 1 0.903724 0.9037 ------Dr.11189.1.S1 at 4.219203 6.376579 5.830209 4.417091 0.008935 0.009295 0.007644 0.009877 0.0076 ------Dr.11193.1.A1 at -1.897 -2.41536 -2.57867 -2.29826 1 0.704 0.677635 0.967902 0.6776 zgc:153411 zgc:153411------Dr.11194.1.A1 at -1.39458 -2.23605 -2.21326 -2.51744 1 0.983 0.999955 0.148945 0.1489 ------Dr.11199.1.A1 at -1.37952 -1.51251 -2.38344 -1.79208 1 1 0.923 1 0.923 ------Dr.11200.1.S1 at -1.00918 -1.9633 -2.33375 -2.28341 1 1 0.775429 0.844324 0.7754 si:ch211-237l4.6 si:ch211-23------Dr.11201.1.S1 at 1.050267 1.387374 1.423162 2.250048 1 1 1 0.863525 0.8635 tubgl , gam--- microtubule-based process /// protein polymerization nucleotide binding /// GTPase activity /// GTP binding microtubule /// protein complex Dr.11202.1.A1 at -1.57518 -2.00179 -2.38079 -2.08786 1 0.999955 0.970422 0.999955 0.9704 cib2 calcium an--- integrin-mediated signaling pathway calcium ion binding --- Dr.11203.1.A1 at -1.49644 -1.85504 -1.44663 -2.3309 1 1 1 0.441 0.441 ------Dr.11205.1.A1 at -1.57553 -1.68367 -2.34838 -1.12812 1 1 0.996244 1 0.9962 ------Dr.11208.1.A1 at -2.14815 -2.61681 -2.69187 -1.85942 0.837872 0.29976 0.069191 1 0.0692 ------Dr.11209.1.A1 at -1.3948 -2.78604 -2.69498 -2.70317 1 0.792839 0.912151 0.842 0.7928 cdh18 cadherin 18--- homophilic cell adhesion calcium ion binding membrane Dr.1122.1.S1 at 1.653259 2.072826 1.713163 1.84028 1 0.9997 1 1 0.9997 zgc:55671 zgc:55671 ------Dr.11232.1.A1 at 1.398718 -1.63207 -2.23088 -1.55681 1 1 0.967715 1 0.9677 ------Dr.11240.1.A1 at -1.22022 -1.85152 -2.08137 -1.53617 1 1 0.998 1 0.998 LOC555251 similar to g ------structural molecule activity intermediate filament Dr.11243.1.A1_at 7.839995 4.215268 3.146552 1.421881 0.090672 0.282857 0.719747 1 0.0907 LOC561585 similar to P--- phosphate metabolic process magnesium ion binding /// inorganic diphosphatase activity cytoplasm

Dr.11249.1.A1 at -1.57931 -1.78267 -1.9689 -2.1418 1 1 1 0.923812 0.9238 ------Dr.1125.1.S1_at -1.29457 1.178141 1.730723 3.145548 1 1 1 0.106092 0.1061 ndpkz3 nucleoside --- GTP biosynthetic process /// UTP biosynthetic process /// nucleotide binding /// nucleoside diphosphate kinase activity --- CTP biosynthetic process /// ATP binding /// kinase activity /// transferase activity

Dr.1126.1.A1_at 1.447531 2.54009 3.324561 4.881847 1 0.093236 0.00994 0.006713 0.0067 rps2 ribosomal p--- translation RNA binding /// structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex

Dr.11261.1.A1_at -1.15676 -1.94328 -1.92896 -2.00831 1 1 1 0.99321 0.9932 a2bp1 ataxin 2-bin--- mRNA processing /// RNA splicing /// hypothalamus nucleotide binding /// nucleic acid binding /// RNA binding nucleus /// cytoplasm development Dr.11266.1.S1 at -1.62338 -1.9216 -1.70445 -2.24821 1 1 1 0.907435 0.9074 ywhag1 3-monooxy ------protein domain specific binding cytoplasm Dr.11275.1.S1_at 1.495303 2.005016 1.778011 3.370111 1 1 1 0.67 0.67 dnajc19 DnaJ (Hsp--- transport /// protein transport /// intracellular protein heat shock protein binding mitochondrion /// mitochondrial inner transport across a membrane membrane /// membrane /// integral to membrane Dr.1129.1.A1 at 4.904653 5.635149 4.250093 2.819065 0.14723 0.118291 0.231 0.436 0.1183 wu:fa99h02 wu:fa99h02------Dr.11290.1.A1 at 2.375864 2.644564 2.2201 1.487548 0.927693 0.782827 0.987 1 0.7828 midn midnolin --- protein modification process --- nucleus Dr.11296.1.S1 at 2.137504 3.821892 4.260008 3.420713 0.992263 0.26508 0.249825 0.382813 0.2498 slc43a1a solute carri------Dr.11302.1.A1_at 1.131985 -1.72209 -2.02802 -2.2039 1 1 0.9997 0.803752 0.8038 ATPase, C--- transport /// cation transport /// calcium ion transport /// catalytic activity /// calcium-transporting ATPase activity /// cytoplasm /// membrane metabolic process /// neuron differentiation calcium ion binding /// ATP binding /// calcium ion transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Dr.11306.1.S1 at 1.467772 2.359157 1.691949 1.341953 1 0.749443 1 1 0.7494 im:7139388 im:7139388------Dr.11308.1.S1_at -1.21377 1.518092 2.040869 2.992609 1 1 0.996 0.394747 0.3947 rplp0 ribosomal p--- translational elongation /// ribosome biogenesis structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.1131.1.A1 at 6.549698 12.61436 9.243257 3.597246 0.014728 0.009348 0.076922 0.165413 0.0093 zgc:110340 zgc:110340------Dr.1131.2.S1 at 1.730709 3.466616 2.596792 1.062188 1 0.258246 0.856743 1 0.2582 zgc:110340 zgc:110340------Dr.11310.2.S1_at 2.476024 10.67341 15.88046 20.24382 0.486901 0.008248 0.007455 0.008868 0.0075 tuba1 tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.11310.2.S1_x_at 1.554147 6.166984 9.127473 12.42987 1 0.036946 0.021858 0.017896 0.0179 tuba1 tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.11310.3.S1_at -1.8696 -1.50464 1.605005 4.870243 1 1 1 0.033167 0.0332 tuba1 /// wu:fb37a10 tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.11310.3.S1_x_at -1.77314 -1.27916 1.595566 4.654509 1 1 1 0.025618 0.0256 tuba1 /// wu:fb37a10 tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.11310.4.S1 at 1.388423 1.565598 1.850452 2.78742 1 1 1 0.530752 0.5308 LOC794625 similar to U------Dr.11312.1.S1 at 3.925678 6.889284 6.855016 5.903569 0.170674 0.019913 0.022626 0.024603 0.0199 hspe1 heat shock --- /// response to stress ATP binding --- Dr.11316.1.S1 at 1.327991 2.497422 2.968929 4.907857 1 0.911 0.708301 0.223363 0.2234 nap1l1 nucleosom--- nucleosome assembly --- nucleus Dr.11316.2.A1 at 3.347783 6.056599 6.240239 9.820805 0.166545 0.011303 0.008192 0.007428 0.0074 wu:fb33e04 wu:fb33e04------Dr.11329.1.A1 at -1.60564 -2.55435 -3.69373 -3.52823 1 0.272 0.055836 0.053933 0.0539 pkib protein kina--- negative regulation of protein kinase activity cAMP-dependent protein kinase inhibitor activity --- Dr.11335.1.S1 at -1.3114 1.36896 2.053099 10.17829 1 1 0.99994 0.009911 0.0099 LOC561086 similar to p------Dr.11336.1.A1 at -1.7193 -1.97751 -2.5562 -2.46504 1 1 0.591443 0.727 0.5914 ------Dr.11345.1.A1 at -2.62451 -4.14476 -5.79686 -4.18891 0.181688 0.030728 0.012217 0.021468 0.0122 lin7a Lin-7 homo------protein binding --- Dr.11347.1.A1 at -1.09533 -1.66868 -2.79606 -2.1694 1 1 0.203354 0.885401 0.2034 im:7139568 /// LOC56200 im:7139568------calcium ion binding --- Dr.11357.1.S1 at -4.48916 -6.31149 -5.62585 -6.38061 0.437658 0.153225 0.11619 0.258246 0.1162 wu:fc17e06 wu:fc17e06------Dr.11359.1.A1_at -2.1177 -2.40471 -3.01306 -2.43953 0.862 0.510417 0.395 0.224932 0.2249 si:dkey-11k24.3 si:dkey-11k --- regulation of transcription, DNA-dependent transcription factor activity /// sequence-specific DNA intracellular /// cytoplasm binding Dr.11369.1.A1 at -1.34808 -1.55163 -1.71838 -2.75938 1 1 1 0.185488 0.1855 ------Dr.1137.1.A1 at 5.035454 6.952225 4.942972 3.068385 0.05 0.015568 0.040958 0.216619 0.0156 wu:fb01b03 Wu:fb01b0 ------Dr.11372.1.A1 at -1.76358 -1.87612 -2.6913 -1.75448 1 1 0.187482 1 0.1875 LOC565404 Similar to R------nucleic acid binding /// zinc ion binding intracellular Dr.11380.1.A1_at 4.976604 32.68768 59.78574 34.69388 0.221835 0.007498 0.007238 0.007694 0.0072 zgc:172278 zgc:172278--- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// electron carrier --- iron ion homeostasis /// oxidation reduction activity /// oxidoreductase activity /// heme binding /// metal ion binding Dr.11394.1.S1 at 2.173442 3.774831 3.255787 3.192991 0.980565 0.254459 0.460421 0.393286 0.2545 calrl2 calreticulin, --- protein folding calcium ion binding /// unfolded protein binding endoplasmic reticulum Dr.11401.1.S1 at 1.181595 1.632604 1.8574 2.24535 1 1 1 0.890256 0.8903 ------Dr.1141.1.A1 at 1.396778 1.835684 1.931194 2.530092 1 1 1 0.169481 0.1695 wu:fb01d11 wu:fb01d11------Dr.11418.1.A1 at -1.42685 -2.22102 -1.29265 -1.8639 1 0.986 1 1 0.986 si:ch211-225p5.3 si:ch211-22------Dr.11431.1.S1 at 1.710401 2.790145 3.198014 3.007405 1 0.185375 0.065602 0.055308 0.0553 hspa4 heat shock --- response to stress nucleotide binding /// ATP binding --- Dr.11434.1.S1 at -2.2127 -1.54652 -1.71308 -1.73789 0.994331 1 1 1 0.9943 abhd2a abhydrolas------carboxylesterase activity /// hydrolase activity membrane /// integral to membrane Dr.11443.1.S1 at 1.530501 1.873179 2.105864 2.042305 1 1 0.999955 0.996927 0.9969 plrg1 pleiotropic ------Dr.1145.1.S1 at 1.683423 2.126737 2.117658 1.563992 1 0.877333 0.996712 1 0.8773 wu:fc20g11 wu:fc20g11------Dr.11471.1.S1 at 1.768823 2.255951 2.081648 2.499237 1 0.636293 0.999955 0.393345 0.3933 chmp5 chromatin m--- transport /// protein transport --- cytoplasm Dr.11474.1.S1_at 1.598472 2.237643 2.295505 1.785055 1 0.497 0.525886 1 0.497 tnfaip1 tumor necr--- DNA replication /// potassium ion transport /// immune voltage-gated potassium channel activity /// protein binding voltage-gated potassium channel complex /// response /// embryonic development /// protein binding membrane Dr.11480.1.S1 at -1.49917 -1.92293 -1.93374 -2.20699 1 1 1 0.99934 0.9993 rap2ip Rap2 intera------Dr.1149.1.A1 a at 1.091637 1.820658 1.717509 2.131343 1 1 1 0.891 0.891 hnrnpa0 heterogene------nucleotide binding /// nucleic acid binding ribonucleoprotein complex Dr.11491.1.S1 at 2.067704 1.518121 1.595789 1.24389 0.982389 1 1 1 0.9824 josd2 Josephin d------Dr.11495.1.A1_at 2.039072 2.264187 2.168018 1.759452 0.996927 0.56765 0.851586 1 0.5676 si:ch211-194e15.1 si:ch211-19--- tRNA processing nucleotide binding /// tRNA isopentenyltransferase activity /// intracellular ATP binding /// zinc ion binding /// transferase activity

Dr.1150.1.S1_at 1.731963 2.192643 2.180646 2.31284 1 0.923812 0.930824 0.721 0.721 pfn2 profilin 2 --- cytoskeleton organization and biogenesis /// actin actin binding actin cytoskeleton cytoskeleton organization and biogenesis Dr.11515.1.A1_at -2.43647 -2.40404 -2.89115 -2.84447 0.81864 0.958184 0.064693 0.638306 0.0647 adnp activity-dep--- protein amino acid phosphorylation protein kinase activity /// protein serine/threonine kinase --- activity /// ATP binding Dr.11519.1.A1_at 1.368203 2.113466 1.588587 1.582669 1 0.938303 1 1 0.9383 m6pr mannose-6--- protein targeting to lysosome /// mannose transport receptor activity /// protein binding /// mannose binding /// lytic vacuole /// trans-Golgi network /// integral mannose binding /// mannose transmembrane transporter to membrane activity /// protein domain specific binding Dr.11526.1.S1 at 1.315165 1.873556 2.049001 2.619713 1 1 1 0.119322 0.1193 cops3 COP9 cons------nucleus /// cytoplasm /// signalosome Dr.11530.1.A1 at 2.380601 1.814871 2.423151 2.93485 0.952481 1 0.915606 0.65 0.65 zgc:152863 zgc:152863------Dr.11532.1.S1 at -1.89666 -2.83207 -2.39298 -3.09968 1 0.699 0.978 0.571464 0.5715 fbxo32 F-box prote------Dr.11537.1.A1 at 1.352043 2.045419 1.212988 1.170509 1 0.9997 1 1 0.9997 zgc:153286 zgc:153286------Dr.11538.1.A1 at -1.8277 -2.06279 -2.01046 -1.5831 1 0.99556 1 1 0.9956 tbc1d19 TBC1 dom--- regulation of GTPase activity Rab GTPase activator activity intracellular Dr.11547.1.S1 at 2.986388 3.792656 2.973201 2.367057 0.160395 0.056498 0.342535 0.888891 0.0565 gclm glutamate-c------oxidoreductase activity /// activity --- Dr.11549.1.S1 at -1.45882 -1.98968 -1.68152 -2.14279 1 1 1 0.978514 0.9785 mpp6 membrane ------protein binding --- Dr.11554.1.A1 at -2.12215 -1.68596 -2.47862 -1.58432 1 1 0.726713 1 0.7267 snx27 sorting nex--- cell communication /// signal transduction protein binding /// phosphoinositide binding --- Dr.11557.1.A1_at -1.92306 -2.64624 -3.11303 -2.05183 1 0.249806 0.112939 0.999955 0.1129 leo1 Leo1, Paf1--- transcription /// transcription termination /// regulation of --- nucleus transcription, DNA-dependent /// transcription antitermination Dr.11571.1.S1_at 3.190095 5.151675 4.942669 4.720107 0.230485 0.018348 0.040585 0.021768 0.0183 cxadr coxsackie v--- kidney development /// cell adhesion /// negative regulation receptor activity /// protein binding signal recognition particle, endoplasmic of signal transduction reticulum targeting /// plasma membrane /// tight junction /// tight junction /// membrane /// integral to membrane /// basolateral plasma membrane /// cell junction

Dr.1160.1.A1_at 1.737278 2.791854 2.836371 2.409157 1 0.163136 0.248 0.563541 0.1631 nat13 N-acetyltra--- somitogenesis /// multicellular organismal development /// N-acetyltransferase activity /// acyltransferase activity /// cytoplasm metabolic process transferase activity Dr.1161.1.S1 at 1.16191 1.611068 2.12953 2.411809 1 1 0.993 0.484443 0.4844 ybx1 Y box bindi--- regulation of transcription, DNA-dependent nucleic acid binding /// DNA binding --- Dr.1162.1.S1 at 1.3001 2.6513 2.958688 3.302241 1 0.369518 0.41967 0.011049 0.011 zgc:73237 zgc:73237 ------Dr.11651.1.S1_at -1.26619 -1.22248 2.5776 5.00857 1 1 0.81438 0.094535 0.0945 mcm5 MCM5 min --- mitotic cell cycle /// DNA replication initiation /// negative nucleotide binding /// DNA binding /// ATP binding nucleus regulation of apoptosis Dr.11661.1.S1 at 2.103944 -1.99778 -2.18984 -1.99702 0.999 0.999955 0.991 1 0.991 ypel3 yippee-like ------Dr.11707.2.A1 at -2.7784 -2.72835 -4.38267 -2.58593 0.797371 0.479177 0.040014 0.616564 0.04 smox spermine o ------electron carrier activity /// oxidoreductase activity --- Dr.11727.1.S1_at -2.13452 -1.70491 -1.40345 -1.35635 0.9997 1 1 1 0.9997 esr2a estrogen re--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// thyroid hormone receptor activity /// steroid binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.11727.1.S2_at -2.16321 -1.94997 -1.98551 -1.54983 0.964549 1 1 1 0.9645 esr2a estrogen re--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.11740.1.A1 at -3.6582 -2.37103 -2.45605 -1.72058 0.630692 0.983 0.997 1 0.6307 wu:fb74h01 wu:fb74h01------Dr.11749.1.A1 at -2.1207 -3.58273 -3.9873 -2.91348 0.981 0.241992 0.124085 0.281355 0.1241 zgc:172197 zgc:172197------protein binding --- Dr.1175.1.A1_at 1.389266 2.146689 1.891432 2.546362 1 0.996789 1 0.794172 0.7942 ndufa10 NADH deh--- nucleobase, nucleoside, nucleotide and nucleic acid ATP binding /// phosphotransferase activity, alcohol group --- metabolic process /// ubiquinone biosynthetic process as acceptor Dr.11758.1.A1 at 1.563448 2.218027 2.541133 2.217526 1 0.976677 0.788658 0.992 0.7887 nsfl1c NSFL1 (p9------Dr.11780.1.A1_at 1.66706 2.691118 1.922375 2.067706 1 0.591 1 0.983712 0.591 top1mt mitochondr--- DNA topological change /// DNA unwinding during DNA binding /// DNA topoisomerase type I activity /// DNA chromosome replication topoisomerase (ATP-hydrolyzing) activity /// isomerase activity Dr.11828.1.A1 at 1.575377 3.125177 6.945731 6.19248 1 0.719 0.161799 0.150342 0.1503 zgc:77806 zgc:77806 ------Dr.11843.1.S1_at 1.353973 2.613986 3.432172 5.069516 1 0.698444 0.226618 0.03646 0.0365 psmb6 proteasome --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome activity /// endopeptidase inhibitor activity /// peptidase core complex /// protein complex activity /// hydrolase activity Dr.1187.1.A1_at -1.15252 1.351411 1.86046 2.078357 1 1 1 0.999917 0.9999 psmc1b proteasome --- protein catabolic process nucleotide binding /// ATP binding /// hydrolase activity /// nucleus /// cytoplasm /// cytosol /// protein nucleoside-triphosphatase activity complex Dr.1191.2.S1 at 2.096931 3.793271 4.337236 4.991293 0.956929 0.1193 0.035954 0.023217 0.0232 zgc:86762 zgc:86762 --- proteolysis --- proteasome regulatory particle Dr.1192.1.S1_a_at 1.434127 1.223632 -1.80251 -2.2614 1 1 1 0.999325 0.9993 ptgds /// zgc:153154 /// zg prostagland--- lipid metabolic process /// transport retinoic acid binding /// prostaglandin-D synthase activity /// --- transporter activity /// binding /// pheromone binding

Dr.1192.1.S1_at -1.19757 -1.00371 -2.2006 -1.43284 1 1 0.999 1 0.999 ptgds prostagland--- lipid metabolic process /// transport retinoic acid binding /// prostaglandin-D synthase activity /// --- transporter activity /// binding Dr.11927.1.A1 at -2.04763 -1.86635 -1.76907 -2.27076 0.999955 1 1 0.887394 0.8874 zgc:113259 Zgc:11325 ------RNA binding /// binding --- Dr.11946.1.A1 at -1.24705 -1.59883 -2.27525 -1.44661 1 1 0.985207 1 0.9852 wu:fj84d07 wu:fj84d07 ------Dr.11957.1.A1 at 2.528862 1.853331 1.475366 1.254973 0.237821 1 1 1 0.2378 ------Dr.11966.1.A1 at 1.69936 2.062321 2.344395 1.845326 1 0.996511 0.685324 1 0.6853 zgc:92794 zgc:92794 ------nucleic acid binding --- Dr.11978.1.A1_at -3.08774 -2.21629 -2.36486 -1.86993 0.328781 0.871 0.860836 1 0.3288 hif1al hypoxia-ind--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// signal nucleus transcription, DNA-dependent /// signal transduction /// transducer activity /// transcription regulator activity transcription antitermination /// regulation of transcription

Dr.1198.1.A1_at 1.571417 2.090676 2.251723 2.41793 1 0.9997 0.896215 0.65638 0.6564 kdelr2l KDEL (Lys --- protein retention in ER lumen /// transport /// protein receptor activity /// ER retention sequence binding endoplasmic reticulum /// membrane /// transport integral to membrane Dr.11982.1.S1 at 2.121821 3.079322 3.514349 3.919307 0.998 0.056356 0.035493 0.015431 0.0154 denr density-reg--- translational initiation translation initiation factor activity --- Dr.11989.1.A1 at 1.190852 1.727656 1.750462 2.138807 1 1 1 0.958523 0.9585 mrpl38 mitochondr------ribosome Dr.1199.1.S1_at 1.83033 2.121132 1.810214 2.116857 1 0.998 1 0.999 0.998 uqcrfs1 ubiquinol-c------ubiquinol-cytochrome-c reductase activity /// electron carrier membrane activity /// oxidoreductase activity Dr.12007.1.A1 at 1.6312 2.392398 1.896667 1.962594 1 0.773 1 0.999955 0.773 ------Dr.1202.2.S1_at 1.634558 3.205476 4.25824 6.171243 1 0.369278 0.074 0.024684 0.0247 rps12 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.1202.3.S1 at 1.240098 2.205041 2.671011 3.280182 1 0.982587 0.200695 0.043888 0.0439 rpl9 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.12020.1.A1_at 1.374399 3.506314 4.157966 7.392056 1 0.613609 0.47 0.14055 0.1405 wu:fc22a06 wu:fc22a06--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.12036.1.A1 at 1.358433 2.083691 2.170586 2.408782 1 0.987303 0.933631 0.889 0.889 ------Dr.1204.1.S1_at 1.606282 1.981464 2.194068 1.489882 1 1 0.858431 1 0.8584 sdad1 SDA1 dom--- transport /// protein transport /// ribosome biogenesis /// --- nucleus /// nucleolus ribosome biogenesis Dr.12070.1.A1 at 1.353923 -2.58755 -3.54094 -2.34364 1 0.234 0.004305 0.197129 0.0043 ------Dr.1208.1.S1 at 1.463205 2.010921 2.110196 2.23418 1 0.999955 0.99934 0.651496 0.6515 c15orf15 chromosom--- translation /// ribosome biogenesis structural constituent of ribosome intracellular /// nucleus /// ribosome Dr.1209.1.S1_at 1.479871 2.888434 2.478364 2.310681 1 0.140516 0.349829 0.595172 0.1405 ssr2 signal sequ------receptor activity endoplasmic reticulum /// integral to membrane Dr.12091.1.A1_at -2.07744 -2.59359 -2.55691 -2.59482 0.988927 0.305 0.795 0.459299 0.305 lama5 laminin, alp--- chemotaxis /// cell adhesion /// signal transduction /// protein receptor activity /// receptor binding proteinaceous extracellular matrix /// basement localization /// cell-cell adhesion /// regulation of cell membrane /// laminin-1 complex /// membrane adhesion /// regulation of cell migration /// pectoral fin /// extracellular matrix morphogenesis /// medial fin morphogenesis /// regulation of embryonic development

Dr.12110.1.S1_at -1.22142 -1.89414 -2.06842 -4.75255 1 1 0.996927 0.007423 0.0074 sc4mol sterol-C4-m--- steroid biosynthetic process /// iron ion transport /// cellular C-4 methylsterol oxidase activity /// catalytic activity /// iron endoplasmic reticulum /// endoplasmic iron ion homeostasis /// metabolic process /// lipid ion binding /// oxidoreductase activity reticulum membrane /// membrane /// integral biosynthetic process /// sterol biosynthetic process /// to membrane oxidation reduction Dr.12119.1.A1 at -1.93392 -2.27417 -1.56278 -1.74746 1 0.931969 1 1 0.932 zgc:109978 Zgc:10997 ------calmodulin binding --- Dr.12129.1.A1 at -2.00219 -2.23598 -1.98135 -2.0776 0.999955 0.866 1 0.999955 0.866 wu:fc46a10 wu:fc46a10------Dr.12134.1.S1 a at -1.41649 -1.72662 -1.48904 -2.11637 1 1 1 0.993564 0.9936 ------Dr.12134.3.S1_x_at -1.26704 -1.60326 -1.41777 -2.09266 1 1 1 0.976 0.976 zgc:162318 zgc:162318------NADH dehydrogenase activity /// NADH dehydrogenase mitochondrion (ubiquinone) activity Dr.12138.2.A1_at 1.821897 2.98874 2.260011 1.996209 1 0.352624 0.973237 1 0.3526 ext1a exostoses (--- heparan sulfate proteoglycan biosynthetic process transferase activity /// transferase activity, transferring endoplasmic reticulum /// endoplasmic glycosyl groups /// glucuronosyl-N-acetylglucosaminyl- reticulum membrane /// membrane /// integral proteoglycan 4-alpha-N-acetylglucosaminyltransferase to membrane /// integral to endoplasmic activity /// glucuronosyl-N-acetylglucosaminyl-proteoglycan 4- reticulum membrane alpha-N-acetylglucosaminyltransferase activity /// N- acetylglucosaminyl-proteoglycan 4-beta- glucuronosyltransferase activity /// N-acetylglucosaminyl- proteoglycan 4-beta-glucuronosyltransferase activity

Dr.12168.1.A1 at 1.424013 2.577939 3.170439 2.772137 1 0.15075 0.278605 0.170776 0.1507 wu:fj09f02 wu:fj09f02 ------Dr.12174.1.A1 at 1.152602 1.269367 1.407102 2.144132 1 1 1 0.968799 0.9688 zgc:101095 zgc:101095------binding /// binding kinesin complex Dr.1218.1.S1 at 1.521532 1.990297 2.111522 1.801195 1 1 0.99321 1 0.9932 exosc2 exosome co------RNA binding --- Dr.12199.1.S1_at 1.931171 2.35637 2.001529 1.845519 1 0.554223 1 1 0.5542 ccnl1 cyclin L1 --- transcription /// transcription termination /// regulation of --- nucleus transcription, DNA-dependent /// transcription antitermination Dr.12215.1.A1 at -1.73777 -2.13957 -1.60912 -2.9497 1 0.995 1 0.617207 0.6172 ------Dr.12216.1.A1_at -2.42439 -2.44619 -3.04619 -2.82925 0.745158 0.648599 0.509857 0.553418 0.5099 si:dkey-12o15.1 si:dkey-12o--- zinc ion transport /// intracellular signaling cascade /// small guanyl-nucleotide exchange factor activity /// calcium ion intracellular GTPase mediated signal transduction /// regulation of small binding /// zinc ion binding /// metal ion binding GTPase mediated signal transduction

Dr.12233.1.S2_a_at -1.13277 1.512246 1.985016 2.820962 1 1 0.999955 0.25596 0.256 pabpc1a poly A bind------nucleotide binding /// nucleic acid binding /// RNA binding ---

Dr.12233.2.S1_x_at 1.395858 1.752271 2.497581 3.073458 1 1 0.92568 0.617142 0.6171 pabpc1a poly A bind------nucleotide binding /// nucleic acid binding /// RNA binding ---

Dr.12255.1.A1 at 5.139305 3.156172 1.511841 1.048582 0.139415 0.601384 1 1 0.1394 ------Dr.12258.1.A1 at -1.28312 -1.99589 -1.60196 -2.30473 1 0.9997 1 0.893679 0.8937 LOC559909 /// nrg1 similar to n--- embryonic development receptor binding --- Dr.12263.1.A1 at -2.1437 -2.64494 -2.97261 -2.61449 0.785808 0.343095 0.055892 0.491855 0.0559 LOC556968 similar to L------Dr.1227.1.S1_at 1.672237 2.095801 2.122389 2.473832 1 1 0.9997 0.589988 0.59 tmem167a transmemb--- negative regulation of signal transduction --- signal recognition particle, endoplasmic reticulum targeting /// membrane /// integral to membrane Dr.12278.1.A1 at 3.095986 3.596584 1.366506 1.308645 0.143171 0.075374 1 1 0.0754 ------Dr.1228.1.A1 at -4.11258 -2.57225 -2.0083 -3.52887 0.023827 0.231733 0.999955 0.367 0.0238 tlcd1 TLC domai------membrane /// integral to membrane Dr.12295.2.A1 at 2.473995 4.086869 4.561569 4.856 0.25574 0.02693 0.027124 0.027875 0.0269 bop1 block of pro--- rRNA processing --- nucleus Dr.12295.2.A1 x at 3.129052 5.007113 5.565177 5.512903 0.335189 0.081535 0.061991 0.072856 0.062 bop1 block of pro--- rRNA processing --- nucleus Dr.12302.1.A1_at 1.191187 1.500611 1.617473 2.375603 1 1 1 0.470887 0.4709 gpd1l Glycerol-3---- carbohydrate metabolic process /// glycerol-3-phosphate catalytic activity /// glycerol-3-phosphate dehydrogenase cytoplasm /// glycerol-3-phosphate metabolic process /// metabolic process /// glycerol-3- (NAD+) activity /// binding /// oxidoreductase activity /// dehydrogenase complex phosphate catabolic process /// oxidation reduction oxidoreductase activity, acting on CH-OH group of donors /// oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor /// coenzyme binding /// NAD binding

Dr.12303.1.A1_at 2.01586 1.91542 1.844957 1.492748 0.987898 1 1 1 0.9879 slc30a1 Solute carr--- cation transport /// zinc ion transport zinc ion transmembrane transporter activity /// cation membrane transmembrane transporter activity Dr.12308.1.S1_at 3.161681 1.958447 1.495785 1.850423 0.190445 1 1 1 0.1904 irf9 interferon r--- transcription /// transcription termination /// regulation of transcription factor activity nucleus transcription, DNA-dependent /// transcription antitermination Dr.12321.1.A1 at 1.145369 -1.48422 -2.25869 -2.44663 1 1 0.92736 0.694599 0.6946 ------Dr.12343.1.S1 at 2.400372 2.663377 2.220608 3.040886 0.793634 0.699 0.999 0.292 0.292 ------Dr.12368.1.A1 at 1.51106 2.229916 2.182286 1.950861 1 0.677873 0.9456 0.999955 0.6779 si:dkey-171o17.2 si:dkey-171--- protein complex assembly --- mitochondrion Dr.1237.1.S1_at 1.35553 2.303493 1.97566 2.423899 1 0.985921 1 0.923744 0.9237 zgc:110014 zgc:110014--- signal peptide processing --- signal peptidase complex /// microsome /// integral to membrane Dr.12378.1.S1_at 1.487029 2.005444 1.890796 2.097443 1 1 1 0.884436 0.8844 hspb1 heat shock --- response to stress /// response to heat /// response to --- nucleus /// nucleolus /// cytoplasm arsenic Dr.12379.1.S1_at -1.53309 -2.05111 -2.43158 -2.15877 1 1 0.35233 0.91 0.3523 il17rd interleukin --- inactivation of MAPK activity /// dorsal/ventral pattern receptor activity signal recognition particle, endoplasmic formation /// negative regulation of signal transduction /// reticulum targeting /// membrane /// integral to negative regulation of fibroblast growth factor receptor membrane /// integral to membrane signaling pathway Dr.12380.1.S1 at 1.056906 1.785771 2.150725 1.866437 1 1 0.995813 1 0.9958 sall1 sal-like 1 (D------Dr.12381.1.A1 at 1.354102 1.277097 1.675426 2.983073 1 1 1 0.577736 0.5777 id:ibd5038 id:ibd5038 ------Dr.12392.1.S1 at 1.251082 1.638533 1.420758 2.324655 1 1 1 0.980792 0.9808 zgc:101128 zgc:101128--- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.1241.1.S1_at 2.653117 2.750448 2.346265 2.212829 0.081324 0.09638 0.646511 0.658727 0.0813 rtcd1 RNA termin--- RNA processing catalytic activity /// RNA-3'-phosphate cyclase activity /// --- ligase activity, forming phosphoric ester bonds Dr.12410.1.S1_at 2.432248 2.719224 1.623808 -1.18969 0.952198 0.796915 1 1 0.7969 spry4 sprouty (Dr--- multicellular organismal development /// regulation of signal --- membrane transduction /// hemopoiesis /// negative regulation of fibroblast growth factor receptor signaling pathway

Dr.12411.1.S1 at 1.536085 2.049029 2.063827 2.227816 1 0.9997 0.999955 0.085754 0.0858 ranbp1 bindin--- intracellular transport ------Dr.12423.1.S1_at 1.159795 1.850363 1.92855 2.55048 1 1 1 0.259105 0.2591 ppia peptidylpro--- protein folding peptidyl-prolyl cis-trans isomerase activity /// isomerase --- activity Dr.12425.2.S1_a_at 4.802891 4.30599 3.22968 2.59087 0.054874 0.059336 0.189744 0.657529 0.0549 zgc:92066 zgc:92066 --- iron ion transport /// cellular iron ion homeostasis binding /// iron ion binding /// ferric iron binding /// --- oxidoreductase activity /// metal ion binding /// transition metal ion binding Dr.12425.4.A1 at 2.691836 4.43069 4.557287 3.325831 0.53846 0.099512 0.056453 0.128 0.0565 hspa14 heat shock --- response to stress nucleotide binding /// ATP binding --- Dr.12425.5.S1_a_at 4.06608 3.619872 2.605149 2.24171 0.057802 0.059763 0.13 0.587732 0.0578 LOC100006428 /// LOC55similar to F--- iron ion transport /// cellular iron ion homeostasis binding /// iron ion binding /// ferric iron binding /// --- oxidoreductase activity /// metal ion binding /// transition metal ion binding Dr.12439.1.S1 at 1.195787 1.709067 2.011567 2.465583 1 1 1 0.321128 0.3211 LOC791452 /// zgc:56493 hypothetica--- cell redox homeostasis ------Dr.12439.3.S1_a_at 1.997751 4.072542 4.577379 7.425679 1 0.365192 0.214812 0.074 0.074 LOC100000999 /// rpl37 hypothetica--- translation /// zinc ion transport RNA binding /// structural constituent of ribosome /// zinc ion intracellular /// ribosome /// ribonucleoprotein binding /// rRNA binding /// metal ion binding complex Dr.12439.6.S1 at -1.59551 -1.86693 -2.33709 -2.20722 1 1 0.987303 0.999917 0.9873 pnrc2 proline-rich ------Dr.1245.1.S1 at -1.02203 1.056462 3.457136 13.11385 1 1 0.270166 0.015844 0.0158 LOC561593 /// LOC79770hypothetica------Dr.12451.1.S1 at -1.82769 -2.88172 -2.30822 -3.39623 1 0.623676 0.941842 0.537622 0.5376 rpepa retinal pigm------Dr.12451.2.A1 at -1.49724 -2.60004 -2.85106 -3.14424 1 0.831599 0.842 0.663206 0.6632 rpepa retinal pigm------Dr.12453.1.A1 at -1.20462 -1.08359 -1.13145 3.393913 1 1 1 0.135503 0.1355 zgc:86764 zgc:86764 ------Dr.12454.1.S1 at -2.76368 -4.57816 -4.39463 -4.2145 0.322 0.02559 0.029698 0.074788 0.0256 gchfr GTP cycloh--- negative regulation of biosynthetic process protein binding --- Dr.12459.1.A1 at 1.118957 1.634369 1.737735 2.157355 1 1 1 0.898232 0.8982 zgc:63561 zgc:63561 ------2 iron, 2 sulfur cluster binding mitochondrial membrane Dr.1246.2.S1_at 1.40082 1.85536 1.963197 2.743006 1 1 1 0.353258 0.3533 atp5f1 ATP syntha--- ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational proton-transporting two-sector ATPase mechanism /// hydrogen ion transporting ATPase activity, complex rotational mechanism Dr.12462.1.A1 at 2.311388 3.733441 3.098748 2.264121 0.030553 0.09927 0.014438 0.961 0.0144 LOC564382 similar to F------Dr.12465.1.S1_at 1.450996 2.337691 2.517675 3.174171 1 0.961 0.893 0.393276 0.3933 si:rp71-45k5.4 si:rp71-45k --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase cytosol /// proteasome core complex /// protein activity /// endopeptidase inhibitor activity /// peptidase complex activity /// hydrolase activity Dr.12469.1.S1 at -1.39988 -1.60465 -2.0589 -1.63307 1 1 0.991636 1 0.9916 arr3l arrestin 3, r--- signal transduction /// sensory perception ------Dr.12474.1.A1 at -1.94772 -2.685 -4.1532 -3.34045 1 0.672567 0.257283 0.297411 0.2573 ------Dr.12481.1.S1 at -1.69701 -1.84 -2.01741 -2.51801 1 1 1 0.670378 0.6704 LOC100001349 /// LOC10similar to p------Dr.12483.1.A1 at -1.01411 -1.06345 1.208981 2.404332 1 1 1 0.92568 0.9257 si:ch211-214j24.2 /// si:ch si:ch211-21------transferase activity --- Dr.12486.1.S1_at -1.77175 -1.66382 -1.92783 -2.21451 1 1 0.999955 0.999917 0.9999 zgc:92247 zgc:92247 ------structural molecule activity tight junction /// membrane /// integral to membrane Dr.12487.1.A1 at 2.282848 1.672512 -1.20653 -1.46347 0.996637 1 1 1 0.9966 scg5 secretogran--- neuropeptide signaling pathway --- secretory granule Dr.12488.1.S1 at -1.29087 1.011205 1.448841 4.213368 1 1 1 0.104381 0.1044 zgc:56200 zgc:56200 --- metal ion transport binding /// metal ion binding --- Dr.12491.1.A1 at 2.657396 5.945023 5.15227 5.515615 0.773 0.071686 0.098971 0.241253 0.0717 LOC794635 similar to c------endopeptidase inhibitor activity /// protein binding extracellular region Dr.12499.1.A1 at 2.39586 3.199844 3.926168 4.898494 0.717427 0.126468 0.096953 0.034259 0.0343 wu:fb93b03 wu:fb93b03------Dr.125.1.A1 at -1.13268 -2.81202 -2.25967 -1.9291 1 0.63 0.977272 0.999955 0.63 wu:fa02e12 wu:fa02e12------Dr.12502.2.S1 x at -2.29686 -2.7803 -1.82467 -3.90585 0.943 0.209671 1 0.085456 0.0855 DKEY-240E12.6 /// DKEYnovel galac ------sugar binding membrane Dr.12502.3.S1 x at -2.09853 -2.54861 -1.56115 -3.4176 0.989 0.322 1 0.233 0.233 DKEY-240E12.6 /// DKEYnovel galac ------sugar binding membrane Dr.12507.1.S1 at -1.2936 -1.13378 -1.03096 2.070445 1 1 1 0.994331 0.9943 LOC556114 hypothetica------Dr.12508.1.A1 at 1.606771 2.996826 1.576569 -1.04035 1 0.38432 1 1 0.3843 zgc:64085 zgc:64085 ------membrane /// integral to membrane Dr.1251.1.S1 at 1.505086 2.085751 1.743507 1.648842 1 0.998 1 1 0.998 degs1 degenerativ--- lipid metabolic process /// oxidation reduction oxidoreductase activity --- Dr.12514.1.A1_at -1.15149 -1.2185 -1.17051 2.231681 1 1 1 0.989 0.989 kif14 kinesin fam--- microtubule-based movement nucleotide binding /// motor activity /// microtubule motor microtubule /// microtubule associated activity /// ATP binding complex Dr.12521.1.S1_at 1.5011 3.515516 3.569704 3.185487 1 0.050563 0.022806 0.029191 0.0228 tomm20 --- protein targeting /// intracellular protein transport --- mitochondrial outer membrane translocase complex Dr.12528.1.A1 at 2.028671 3.000059 2.864802 2.798286 0.991488 0.078 0.263916 0.112144 0.078 zgc:92670 zgc:92670 ------ribosome Dr.12547.1.A1 at 1.737897 2.314647 1.720251 2.250943 1 0.559 1 0.897 0.559 LOC560944 similar to p ------Dr.12554.1.A1 at -2.38309 -2.61157 -4.95061 -3.00439 0.875923 0.755903 0.151646 0.533358 0.1516 ------Dr.12561.1.A1_at -1.1873 -2.58564 -2.71402 -3.10781 1 0.383257 0.659609 0.02172 0.0217 camk2d2 calcium/ca --- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// calmodulin-dependent protein kinase activity /// calmodulin binding /// ATP binding /// kinase activity /// transferase activity Dr.12562.1.A1 at 1.039575 1.804385 2.007639 1.261824 1 1 0.997562 1 0.9976 ------Dr.12564.1.A1 at 2.104043 -1.3848 -1.62225 -1.37285 0.99934 1 1 1 0.9993 ------Dr.12565.1.A1 at -1.41652 -2.16317 -3.65552 -2.60114 1 0.898 0.011988 0.362341 0.012 wu:fa12e08 wu:fa12e08------Dr.12573.1.S1_at -2.07322 -2.14055 -1.59587 -2.11532 0.98777 0.784311 1 0.937651 0.7843 sox32 SRY-box c--- endoderm formation /// endoderm formation /// heart DNA binding /// DNA binding /// transcription factor activity nucleus morphogenesis /// regulation of transcription, DNA- /// transcription factor activity dependent /// determination of left/right symmetry /// endoderm development /// endodermal cell fate determination /// mesoderm development /// embryonic heart tube development /// cell migration involved in gastrulation /// positive regulation of transcription, DNA-dependent /// positive regulation of transcription, DNA-dependent

Dr.12583.1.S1_at 2.467759 3.28661 2.711889 2.749356 0.951728 0.73 0.945853 0.913 0.73 igfbp3 insulin-like --- skeletal development /// regulation of cell growth /// otic insulin-like growth factor binding /// insulin-like growth factor extracellular region /// nucleus /// insulin-like vesicle formation /// inner ear morphogenesis /// insulin-like binding growth factor binding protein complex growth factor receptor signaling pathway /// insulin-like growth factor receptor signaling pathway Dr.12583.2.A1_at 3.317557 4.31923 4.136029 3.815535 0.454398 0.196249 0.152297 0.179266 0.1523 igfbp3 insulin-like --- skeletal development /// regulation of cell growth /// otic insulin-like growth factor binding /// insulin-like growth factor extracellular region /// nucleus /// insulin-like vesicle formation /// inner ear morphogenesis /// insulin-like binding growth factor binding protein complex growth factor receptor signaling pathway /// insulin-like growth factor receptor signaling pathway Dr.12585.1.S1_at -2.66581 -3.25579 -3.0554 -2.83537 0.950415 0.763795 0.919 0.921 0.7638 myo3a IIIA --- protein amino acid phosphorylation nucleotide binding /// motor activity /// protein kinase activity myosin complex /// protein serine/threonine kinase activity /// ATP binding

Dr.12589.1.S1_at -2.1578 -1.84365 -2.0084 -1.88953 0.99994 1 0.999955 1 0.9999 jag1b jagged 1b --- liver development /// calcium ion transport /// cell calcium channel activity /// calcium ion binding /// calcium signal recognition particle, endoplasmic communication /// Notch signaling pathway /// Notch channel inhibitor activity /// protease inhibitor activity reticulum targeting /// membrane /// integral to signaling pathway /// multicellular organismal development membrane /// integral to membrane /// negative regulation of signal transduction /// pancreas development Dr.1259.1.A1 at 5.02744 4.971987 5.110592 4.00198 0.045893 0.04708 0.056933 0.177 0.0459 wu:fa98e11 wu:fa98e11------Dr.12592.1.S1_at 1.906642 2.223723 1.733372 1.088263 0.998961 0.993617 1 1 0.9936 guca1a guanylate c--- calcium ion transport calcium channel activity /// calcium ion binding /// calcium --- ion binding /// calcium channel inhibitor activity /// activator activity Dr.12594.1.S1_at 7.740325 12.35257 8.957637 6.500172 0.073297 0.009738 0.04751 0.029698 0.0097 xbp1 X-box bindi--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// transcription nucleus regulator activity /// sequence-specific DNA binding /// protein dimerization activity Dr.12595.1.S1_at -2.33677 1.084331 -1.22283 -1.01876 0.903724 1 1 1 0.9037 hsf2 heat shock --- regulation of transcription, DNA-dependent /// response to DNA binding /// transcription factor activity /// sequence- nucleus stress specific DNA binding /// sequence-specific DNA binding

Dr.12599.1.S1 at -2.53575 -2.46466 -2.19374 -2.66198 0.989 0.994659 0.99994 0.975795 0.9758 ncam1 neural cell --- cell adhesion protein binding membrane Dr.1260.1.S1_at 2.105815 13.86429 27.11607 71.77962 0.999 0.14 0.023756 0.012542 0.0125 anxa2a annexin A2 --- calcium ion transport phospholipase inhibitor activity /// calcium channel activity /// --- calcium ion binding /// calcium-dependent phospholipid binding /// cytoskeletal protein binding /// calcium channel inhibitor activity Dr.12604.1.S1_at -1.34333 -2.1589 -2.24696 -2.42204 1 0.962 0.891689 0.709 0.709 sox10 SRY-box c--- neural crest cell migration /// regulation of transcription, DNA binding chromatin /// nucleus DNA-dependent /// Schwann cell differentiation /// Schwann cell development /// enteric nervous system development /// oligodendrocyte differentiation /// negative regulation of neurogenesis Dr.12605.1.S1_at -2.38161 -2.44603 -3.14904 -2.57148 0.99934 0.9942 0.792505 0.980064 0.7925 cdkn1b cyclin-depe--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// nucleus /// cytoplasm tyrosyl-tRNA aminoacylation /// cell cycle arrest tyrosine-tRNA ligase activity /// cyclin-dependent protein kinase inhibitor activity /// ATP binding /// kinase activity /// ligase activity Dr.12642.1.A1 at -1.27524 -2.34257 -3.60492 -2.20438 1 0.752774 0.072116 0.872327 0.0721 ------Dr.12662.1.A1_at -1.28856 -1.83051 -1.29909 -2.13024 1 1 1 0.994 0.994 LOC795887 hypothetica--- protein amino acid phosphorylation /// small GTPase protein serine/threonine kinase activity /// GTP binding --- mediated signal transduction Dr.12668.1.A1 at -1.00755 -1.02476 -1.03993 2.267309 1 1 1 0.9997 0.9997 LOC557879 similar to S ------Dr.12672.1.A1_at 2.598281 4.397514 3.500567 4.278583 0.429444 0.114084 0.098748 0.058066 0.0581 timm44 translocase --- intracellular protein transport P-P-bond-hydrolysis-driven protein transmembrane mitochondrial inner membrane presequence transporter activity translocase complex Dr.12674.1.S1 at -1.60537 -1.88559 -2.53358 -1.86346 1 0.999955 0.923793 1 0.9238 zgc:112307 zgc:112307--- protein amino acid phosphorylation protein kinase activity /// ATP binding --- Dr.12675.1.S1_at 1.473586 2.094087 2.436256 2.774305 1 0.990835 0.60853 0.25077 0.2508 usp14 ubiquitin sp--- protein modification process /// ubiquitin-dependent protein ubiquitin thiolesterase activity /// endopeptidase inhibitor --- catabolic process activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity Dr.12679.1.S1_at -1.08484 -1.14681 1.06407 6.131484 1 1 1 0.01785 0.0179 ect2 epithelial ce--- intracellular signaling cascade /// regulation of Rho protein guanyl-nucleotide exchange factor activity /// Rho guanyl- intracellular signal transduction nucleotide exchange factor activity Dr.12688.1.A1_at 1.595212 2.418193 2.311466 2.248658 1 0.240212 0.493946 0.86648 0.2402 ptk2.2 Protein tyro--- protein amino acid phosphorylation /// signal complex nucleotide binding /// protein kinase activity /// protein cytoskeleton /// focal adhesion assembly tyrosine kinase activity /// signal transducer activity /// ATP binding /// kinase activity /// transferase activity Dr.12690.1.A1 at 2.395296 -1.26614 -1.25323 -1.09685 0.793411 1 1 1 0.7934 ------Dr.12694.1.A1 at 2.20164 2.326128 2.06045 1.451662 0.85444 0.763742 1 1 0.7637 ------Dr.12695.1.A1 at -3.20981 -4.81674 -4.66927 -1.91122 0.042 0.061321 0.011968 1 0.012 ------Dr.12713.1.S1 at 1.958998 2.720668 3.530995 3.503485 1 0.018592 0.008384 0.03775 0.0084 pitpna phosphatid--- transport /// axonogenesis --- intracellular Dr.12715.1.S1 at 1.989716 2.41947 2.114522 1.401582 0.996 0.293571 0.974275 1 0.2936 ctage5 CTAGE fam------Dr.12725.1.A1_at 2.734556 3.283353 2.654481 1.603309 0.802308 0.298765 0.770611 1 0.2988 zgc:112143 zgc:112143--- metabolic process catalytic activity /// binding /// iron ion binding /// electron integral to membrane carrier activity /// oxidoreductase activity /// FAD binding

Dr.12730.1.A1 at -1.07976 1.271425 1.15427 2.132857 1 1 1 0.994 0.994 gpsm2 G-protein s--- signal transduction GTPase activator activity /// binding --- Dr.12739.1.A1 at -2.38067 -4.83925 -7.36954 -5.51415 0.929921 0.254696 0.091259 0.135712 0.0913 ------Dr.12740.1.A1 at -2.48698 -5.26988 -6.19099 -6.18164 0.997562 0.585725 0.476 0.473247 0.4732 ------metabolic process catalytic activity --- Dr.12746.1.A1 at -2.56573 -3.39919 -4.78642 -3.18334 0.507 0.324852 0.045195 0.112869 0.0452 kcnh2 Potassium ------Dr.12749.1.A1 at -1.12163 -1.77021 -2.23682 -1.57883 1 1 0.180204 1 0.1802 ------Dr.12760.1.A1 at -1.66503 -2.45565 -4.89932 -2.88601 1 0.616795 0.022806 0.011641 0.0116 zgc:73355 zgc:73355 ------cytochrome-c oxidase activity --- Dr.12762.1.A1 at -2.25497 -2.29167 -2.49056 -2.37518 0.990835 0.977272 0.876 0.927693 0.876 pdc2 phosducin ------Dr.12767.1.A1 at -1.83359 -2.11281 -1.77988 -2.68408 1 0.999325 1 0.745348 0.7453 ------Dr.12771.1.A1_at 1.67031 2.080805 1.623501 2.320204 1 1 1 0.913 0.913 slc30a9 solute carri--- transcription /// transcription termination /// regulation of nucleotide binding /// zinc ion transmembrane transporter nucleus /// membrane /// integral to membrane transcription, DNA-dependent /// transport /// ion transport activity /// zinc ion binding /// cation transmembrane /// cation transport /// zinc ion transport /// zinc ion transport transporter activity /// transcription antitermination Dr.12775.1.A1_at -1.14169 -1.32456 -1.72567 -2.16537 1 1 1 0.96723 0.9672 zgc:73226 zgc:73226 --- positive regulation of apoptosis --- mitochondrial envelope /// integral to membrane Dr.12777.1.S1_at 2.215806 1.104174 1.211318 1.152135 0.997143 1 1 1 0.9971 pcdh10b protocadhe--- somitogenesis /// calcium ion transport /// homophilic cell calcium channel activity /// calcium ion binding /// calcium membrane adhesion /// paraxial mesoderm development channel inhibitor activity Dr.12778.1.S1 at 2.512452 2.532243 1.659121 1.444179 0.590584 0.621582 1 1 0.5906 LOC556901 similar to a------Dr.12785.1.A1 at -1.6186 -1.88479 -1.37163 -2.2446 1 1 1 0.831 0.831 ------Dr.12789.1.A1 at 1.26117 -1.63264 -2.47452 -1.9661 1 1 0.929 0.999955 0.929 ------Dr.12790.1.A1 at -2.0757 -2.51072 -2.9371 -2.54137 1 0.987421 0.886199 0.986 0.8862 DKEY-10P5.9 /// LOC100 trinucleotid------Dr.12809.1.A1_at -1.70569 -2.74674 -3.22626 -2.43165 1 0.521669 0.149615 0.450395 0.1496 zgc:73259 zgc:73259 --- carbohydrate metabolic process /// glycogen metabolic ------process Dr.12816.1.A1 at -1.41538 -1.51841 -1.32939 -2.04665 1 1 1 0.970422 0.9704 ------Dr.12817.1.A1 at 3.342536 1.717939 -1.1283 1.008863 0.424 1 1 1 0.424 si:rp71-39b20.7 Si:rp71-39b--- signal transduction /// response to bacterium receptor binding --- Dr.1282.1.S1 at 4.044927 5.389424 5.133849 5.309474 0.41967 0.247457 0.297295 0.267622 0.2475 krt8 keratin 8 ------structural molecule activity intermediate filament Dr.1282.2.S1 at 2.029801 3.797101 4.90662 7.32065 1 0.363 0.177913 0.081187 0.0812 rps26l ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.12821.1.A1_at -1.41075 -1.33071 -1.41528 -2.13753 1 1 1 0.741213 0.7412 zgc:85969 zgc:85969 --- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding Dr.12826.1.A1 at -1.96118 -3.24157 -4.29964 -3.09813 1 0.246608 0.028033 0.22795 0.028 ------Dr.12829.1.A1 at -1.71463 -1.41181 -2.80163 -2.5611 1 1 0.760776 0.94396 0.7608 zgc:85746 zgc:85746 --- calcium-mediated signaling ------Dr.1283.1.S1 at 3.260794 4.544147 5.108332 3.823895 0.107731 0.050812 0.036818 0.059184 0.0368 wu:fa99c08 wu:fa99c08------nucleus Dr.12832.1.S1_at 1.03995 1.403622 1.648089 2.112463 1 1 1 0.999917 0.9999 ndufs4 NADH deh--- ubiquinone biosynthetic process /// electron transport chain oxidoreductase activity, acting on NADH or NADPH mitochondrial inner membrane

Dr.12842.1.S1 at -2.15167 -1.46349 -1.32729 -1.78351 0.9997 1 1 1 0.9997 tcf12 transcriptio--- regulation of transcription transcription regulator activity nucleus Dr.12848.1.S1 at -2.22754 -3.22585 -4.32375 -4.56928 1 0.814504 0.463672 0.440502 0.4405 ------Dr.12849.2.A1 a at 2.090928 -1.24711 -1.6617 -1.42044 0.993564 1 1 1 0.9936 ------Dr.12851.1.S1 at 1.385279 1.991859 2.132423 2.025021 1 1 0.99934 1 0.9993 zgc:103495 zgc:103495------ribosome Dr.12852.1.S1_at -1.29431 -2.19368 -2.7423 -1.70492 1 0.956 0.210796 1 0.2108 fkbp1b FK506 bind--- protein folding peptidyl-prolyl cis-trans isomerase activity /// isomerase --- activity Dr.12858.1.A1 at 1.948107 2.415859 2.527599 3.102298 0.999955 0.983712 0.985663 0.797371 0.7974 ------Dr.12859.1.S1 at -1.1535 -1.46169 -1.78087 -2.18134 1 1 1 0.98838 0.9884 LOC567608 similar to h------Dr.12862.1.A1 at -1.74403 -4.605 -4.76285 -3.95904 1 0.197484 0.051653 0.089277 0.0517 ------Dr.12867.1.A1 at 3.012613 1.442295 1.671394 1.342755 0.34353 1 1 1 0.3435 ------Dr.12869.1.A1 at -1.03342 -1.92922 -2.99202 -2.12678 1 1 0.093195 0.691441 0.0932 ------Dr.12878.1.S1 x at -1.90192 -1.96836 -1.78068 -2.23005 1 1 1 0.998 0.998 ogtl O-linked N- --- RNA processing binding intracellular Dr.12878.3.A1_a_at -1.76439 -2.04779 -1.88804 -2.59099 1 0.999955 1 0.988806 0.9888 ogt /// ogtl O-linked N- --- RNA processing /// protein amino acid O-linked binding /// protein binding /// protein N- intracellular glycosylation acetylglucosaminyltransferase activity /// transferase activity

Dr.12878.3.A1_x_at -1.90962 -1.89715 -2.1099 -2.66106 1 1 0.999955 0.991918 0.9919 ogt O-linked N- --- protein amino acid O-linked glycosylation binding /// protein binding /// protein N- --- acetylglucosaminyltransferase activity /// transferase activity

Dr.12882.1.A1_at -2.36015 -2.98345 -2.42556 -3.05538 0.991 0.231767 0.892 0.563523 0.2318 hs6st1a heparan su------transferase activity /// heparan sulfate 6-O-sulfotransferase membrane /// integral to membrane activity Dr.12886.1.A1 at -1.58145 -1.59478 -1.26807 -2.21655 1 1 1 0.909 0.909 ------Dr.1289.1.S1 at -2.0423 -1.60913 -2.43583 -2.4645 0.999955 1 0.65029 0.540664 0.5407 zgc:91870 zgc:91870 ------Dr.12892.1.A1 at 1.726923 2.126104 1.600776 1.284018 1 0.901 1 1 0.901 zgc:110775 zgc:110775------Dr.12898.1.A1 at 2.148927 -1.19484 -1.65695 -1.32182 0.998 1 1 1 0.998 ------Dr.12899.1.A1 at 4.016033 4.653249 3.312475 2.009471 0.075242 0.051756 0.416271 1 0.0518 ------Dr.12904.1.A1_at 2.445276 -1.30842 -1.09499 -1.36196 0.638101 1 1 1 0.6381 rorcb RAR-relate--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.12910.1.A1_at 1.342271 2.291118 1.637396 1.373954 1 0.977266 1 1 0.9773 dab2ip DAB2 inter--- regulation of small GTPase mediated signal transduction GTPase activator activity intracellular

Dr.12914.1.A1 at -2.83664 -3.54497 -3.32609 -3.59515 0.681362 0.308316 0.415946 0.33642 0.3083 LOC559006 similar to W------Dr.12929.1.A1 at 2.268946 1.545375 1.294904 1.254598 0.862 1 1 1 0.862 ------Dr.1294.1.S1_at -1.04208 1.58884 1.913264 6.308136 1 1 1 0.019812 0.0198 fen1 flap structu--- DNA repair /// retina development in camera-type eye DNA binding /// catalytic activity /// nuclease activity /// nucleus endonuclease activity /// 5'-3' exonuclease activity Dr.12941.1.A1 at -1.38266 -2.19346 -3.87135 -2.82622 1 0.99994 0.039342 0.142626 0.0393 im:7139568 /// LOC56200 im:7139568------calcium ion binding --- Dr.12949.1.S1 at -2.18486 -2.77786 -3.63218 -6.12742 0.999955 0.87033 0.305557 0.182 0.182 dio2 deiodinase --- response to hormone stimulus thyroxine 5'-deiodinase activity /// selenium binding --- Dr.12950.2.S1_a_at 1.664767 2.175059 2.17513 2.52757 1 0.852348 0.999 0.300393 0.3004 tipin timeless int--- DNA replication checkpoint /// response to DNA damage --- nuclear chromatin /// nucleus /// nucleus /// stimulus /// cell cycle /// mitosis /// positive regulation of cell cytoplasm proliferation /// intra-S DNA damage checkpoint /// regulation of S phase /// replication fork protection /// cell division Dr.12952.1.S1 at 2.283113 3.427885 3.244318 3.33314 0.92337 0.289183 0.436 0.297868 0.2892 prelid1 PRELI dom------Dr.12959.1.A1 at 1.573216 2.123373 1.132814 1.015674 1 0.778982 1 1 0.779 wu:fb96h11 wu:fb96h11------Dr.12963.1.A1 at -2.06059 -1.38069 -2.79007 -3.22065 0.997 1 0.500517 0.086453 0.0865 ------Dr.1299.1.A1 at 2.553244 -1.30623 -1.15132 -1.0416 0.928 1 1 1 0.928 wu:fc67d01 wu:fc67d01------Dr.12995.1.A1 at -1.46457 -1.67717 -1.37581 -2.03409 1 1 1 0.996244 0.9962 ------Dr.12999.1.A1 at 1.029371 1.599278 1.776976 2.071818 1 1 1 0.971 0.971 LOC100003771 similar to m------Dr.13005.1.A1_at 1.737146 2.956703 2.364098 2.009435 1 0.151 0.483 1 0.151 wu:fj23a05 wu:fj23a05 --- zinc ion transport nucleic acid binding /// protein binding /// zinc ion binding /// intracellular /// nucleus metal ion binding Dr.13007.1.A1 at 1.55879 4.270639 4.142054 2.358359 1 0.151326 0.167736 0.95781 0.1513 LOC100000303 similar to p------Dr.13015.1.S1_at -1.11668 1.257122 1.500329 12.65283 1 1 1 0.027873 0.0279 lgals1l2 /// LOC791523 lectin, galac--- vasculature development /// sprouting angiogenesis sugar binding /// galactoside binding /// galactoside binding --- /// laminin binding Dr.13030.1.A1 at -1.51313 -2.24333 -2.32041 -2.87588 1 0.899362 0.848882 0.380165 0.3802 zgc:64006 Zgc:64006 ------signal transducer activity --- Dr.13039.1.S1 at 3.640168 1.304054 1.431418 2.384797 0.285236 1 1 0.9997 0.2852 zgc:56271 zgc:56271 ------Dr.13050.1.S1 at 2.884139 3.901014 4.261523 7.48235 0.261878 0.097 0.054508 0.014871 0.0149 zgc:110459 zgc:110459------Dr.13051.1.A1 at -3.43551 -3.46052 -4.579 -3.0676 0.042305 0.096 0.03615 0.094 0.0362 ------Dr.13053.2.S1 at -1.56379 -1.67166 -1.55793 -2.27069 1 1 1 0.948 0.948 ------Dr.13054.1.A1 at -3.19282 -3.55324 -4.07291 -3.65954 0.596324 0.483995 0.536669 0.4 0.4 ------Dr.13069.1.A1 at -2.19893 1.003581 -1.004 -1.24708 0.752456 1 1 1 0.7525 ------Dr.13086.1.A1_at -2.0104 -1.92437 -1.64767 -2.11915 0.999955 1 1 0.9997 0.9997 zgc:91878 zgc:91878 ------structural molecule activity tight junction /// membrane /// integral to membrane Dr.1309.1.S1 at 3.002744 3.783414 4.331623 4.07954 0.366 0.095376 0.031812 0.060401 0.0318 ------Dr.13097.1.S1_at -1.4319 -2.02351 -1.96892 -1.48625 1 0.99994 1 1 0.9999 pfkfb4 6-phosphof --- fructose metabolic process /// fructose 2,6-bisphosphate catalytic activity /// 6-phosphofructo-2-kinase activity /// ATP --- metabolic process /// metabolic process binding /// kinase activity Dr.1310.2.S1_a_at 1.20372 2.789362 3.344305 4.874331 1 0.87835 0.458 0.12206 0.1221 rpl24 ribosomal p--- translation /// multicellular organismal development structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.13114.1.A1 at 3.258611 5.173824 4.5585 2.473521 0.109 0.012531 0.06604 0.643889 0.0125 rhov ras homolo--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular /// membrane Dr.13121.1.A1 at -1.85992 -2.736 -1.5792 -2.97947 1 0.487647 1 0.375312 0.3753 ------Dr.13121.1.A1 x at -1.76803 -2.37641 -1.52484 -2.8488 1 0.858 1 0.451829 0.4518 ------Dr.1313.1.S1_at 1.467151 3.371464 4.095616 6.182988 1 0.291927 0.038726 0.012777 0.0128 rpl18a ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.13132.1.A1 at 1.564029 1.820419 2.021777 2.195112 1 1 1 0.998 0.998 akr1a1b aldo-keto re------oxidoreductase activity --- Dr.13156.1.A1 at -1.41588 -1.86457 -1.65612 -2.16483 1 1 1 0.926619 0.9266 ------Dr.13161.1.S1 at 3.618726 6.006351 5.291207 3.949196 0.135639 0.056425 0.051983 0.087546 0.052 gadd45bl growth arre--- somitogenesis /// somitogenesis ------Dr.13163.1.A1 at 1.907807 2.424779 1.962204 1.569166 1 0.954 1 1 0.954 ------Dr.13168.1.S1_at -1.0619 2.101357 2.166478 2.931029 1 0.969 0.999917 0.197961 0.198 ncbp2 nuclear cap --- snRNA export from nucleus /// RNA splicing /// positive nucleotide binding /// nucleic acid binding /// RNA binding /// nucleus regulation of RNA export from nucleus protein binding Dr.13173.1.S1 at 1.666604 2.327375 2.969491 2.977719 1 0.693388 0.148356 0.108429 0.1084 psmd7 proteasome ------cytosol /// protein complex Dr.13180.1.S1_at 5.620337 6.083666 5.703147 4.382317 0.036339 0.154393 0.038814 0.076815 0.0363 uck2b uridine-cyti--- metabolic process nucleotide binding /// ATP binding /// kinase activity /// --- transferase activity /// phosphotransferase activity, alcohol group as acceptor Dr.1320.1.S1_at 1.263449 3.263235 4.276916 6.365895 1 0.069474 0.02339 0.010856 0.0109 nme2 non-metast--- GTP biosynthetic process /// UTP biosynthetic process /// nucleotide binding /// nucleoside diphosphate kinase activity --- CTP biosynthetic process /// ATP binding /// kinase activity /// transferase activity

Dr.13209.1.A1 at -1.5487 -2.01251 -1.38632 -1.80193 1 0.998 1 1 0.998 ------Dr.1324.1.S1_at 1.461925 3.067251 3.744107 4.870491 1 0.181275 0.013538 0.016947 0.0135 rps5 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex

Dr.13244.1.A1 at -2.0089 -2.11449 -2.23328 -2.05791 0.997562 0.9456 0.839414 0.987228 0.8394 zgc:152987 zgc:152987------Dr.13267.1.A1 at -1.31345 -1.76828 -1.40062 -2.14786 1 1 1 0.996964 0.997 ------Dr.13269.1.A1 at 1.94656 2.068166 1.816486 1.475819 1 0.999 1 1 0.999 si:ch211-257c9.1 si:ch211-25--- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.13270.1.A1 at -1.62045 -1.4749 -1.16719 2.789242 1 1 1 0.655328 0.6553 ------Dr.13282.1.S1 at -1.7616 -2.05213 -2.57558 -3.27892 1 0.999955 0.976942 0.72035 0.7203 gas1b growth arre------Dr.13284.2.S1 at 1.695799 2.199736 1.337082 1.269969 1 0.985921 1 1 0.9859 chka choline kina------kinase activity --- Dr.13285.1.A1_at 2.070242 1.997376 2.172122 1.563502 0.9997 1 0.987 1 0.987 rasgef1bb RasGEF do--- proteolysis /// small GTPase mediated signal transduction /// guanyl-nucleotide exchange factor activity /// zinc ion binding intracellular regulation of small GTPase mediated signal transduction

Dr.13286.1.S1 at 3.45241 4.226215 4.060776 3.892843 0.086433 0.021169 0.035918 0.055495 0.0212 zgc:66377 zgc:66377 ------ATP binding chromosome Dr.13289.1.A1 at -2.5427 -1.02125 1.0259 1.663989 0.456256 1 1 1 0.4563 ------Dr.1329.1.S1 at 1.706414 2.965621 3.44745 4.153944 1 0.104272 0.029926 0.023167 0.0232 rpl10 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.133.1.A1 at -1.16991 -1.13236 -1.04138 4.08503 1 1 1 0.04448 0.0445 si:ch211-255a21.1 si:ch211-25------Dr.1330.1.S1_at -1.45351 -1.96654 -2.99922 -2.66622 1 1 0.109776 0.39067 0.1098 sepp1a selenoprote--- response to oxidative stress /// negative regulation of signal selenium binding extracellular region /// extracellular region /// transduction signal recognition particle, endoplasmic reticulum targeting Dr.13300.1.S1_at 2.249009 3.580282 3.581978 3.554282 0.999955 0.459 0.499249 0.525715 0.459 zgc:73356 zgc:73356 --- transport /// protein transport /// intracellular protein --- mitochondrion /// mitochondrial inner transport across a membrane membrane /// membrane Dr.13333.1.S1 at 1.492172 2.346411 2.247242 2.338888 1 0.450797 0.924 0.608449 0.4508 thoc3 THO comp------Dr.13334.1.S1 at 1.259032 1.771943 2.170403 3.416051 1 1 0.998 0.231825 0.2318 zgc:153700 zgc:153700------Dr.1334.1.S1 at 1.256671 2.238029 2.640899 3.009219 1 0.057373 0.020318 0.019067 0.0191 rps25 ribosomal p------ribosome /// ribonucleoprotein complex Dr.13341.1.S1 at -1.26419 -1.81694 -2.16876 -2.53919 1 1 0.927417 0.608642 0.6086 sept7b septin 7b --- cell cycle nucleotide binding /// protein binding /// GTP binding septin complex Dr.13349.1.S1 at 1.431102 2.336008 2.355656 2.952527 1 0.373 0.767548 0.090833 0.0908 LOC794620 /// sap18 similar to s ------Dr.1335.1.S1_at 2.069487 3.353958 4.214527 5.132001 1 0.461896 0.202411 0.078383 0.0784 rpl36 ribosomal p--- translation /// brain development structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.13376.1.S1 at 1.647603 2.269225 2.530387 2.417822 1 0.968057 0.792878 0.831599 0.7929 wdr5 WD repeat ------Dr.13376.1.S2 at 2.613784 3.893934 3.732316 4.392113 0.774703 0.279382 0.325359 0.207584 0.2076 wdr5 WD repeat ------Dr.1338.1.S1 at 1.535196 2.904636 3.89482 5.765124 1 0.428649 0.06256 0.02342 0.0234 rpl28l ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.13383.1.S1 at -1.13741 -1.06259 1.070625 2.655656 1 1 1 0.145577 0.1456 zgc:162162 zgc:162162------Dr.13385.1.S1 at 1.661237 2.54044 2.473757 2.469146 1 0.952 0.962 0.976817 0.952 ------Dr.1339.1.S1_at 1.102957 1.831683 2.217012 2.610372 1 1 0.774703 0.080285 0.0803 rps11 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.134.1.S1_a_at 1.998402 3.572063 3.85304 3.344214 0.996758 0.027377 0.031589 0.031421 0.0274 cct7 chaperonin --- protein folding /// cellular protein metabolic process nucleotide binding /// protein binding /// ATP binding /// cytoplasm unfolded protein binding Dr.1340.1.S1 at 1.002612 1.601153 1.780363 2.120232 1 1 1 0.977 0.977 uba52 ubiquitin A---- translation /// protein modification process structural constituent of ribosome intracellular /// ribosome Dr.13404.1.A1_at 2.096989 4.017596 5.617076 8.181278 0.99 0.046476 0.079501 0.012977 0.013 uck2a uridine-cyti--- metabolic process nucleotide binding /// ATP binding /// kinase activity /// --- transferase activity /// phosphotransferase activity, alcohol group as acceptor Dr.13408.1.S1_at -2.31137 -3.41141 -3.60378 -3.53297 0.997 0.678334 0.581233 0.69 0.5812 zgc:123242 Zgc:123242--- transport /// ion transport /// calcium ion transport ion channel activity /// chloride channel activity /// calcium plasma membrane /// membrane /// integral to channel activity /// calcium ion binding /// calcium channel membrane inhibitor activity /// chloride channel inhibitor activity /// chloride ion binding Dr.13413.1.S1 at -1.0899 -1.72529 -1.71668 -2.03444 1 1 1 0.969 0.969 ------Dr.13421.1.S1 at 1.584606 1.878511 2.209251 1.829649 1 1 0.941866 1 0.9419 ------Dr.13435.1.A1_at -3.00009 -3.67469 -3.40321 -3.02372 0.956929 0.782795 0.836863 0.923697 0.7828 zgc:136878 zgc:136878--- DNA replication /// transcription /// transcription termination DNA binding /// transcription factor activity intracellular /// nucleus /// regulation of transcription, DNA-dependent /// transcription antitermination Dr.13441.1.A1 at 2.201176 -1.00548 1.112657 1.247259 0.953 1 1 1 0.953 ------Dr.13448.1.S1 at -1.94472 -2.00287 -1.76791 -2.34589 1 1 1 0.999325 0.9993 ------Dr.1345.1.S1_at 1.416609 2.875869 3.449032 4.505047 1 0.109236 0.019845 0.017762 0.0178 zgc:171710 zgc:171710--- translation structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex

Dr.13466.1.A1 at -1.31315 -2.08073 -1.77335 -2.03117 1 0.99994 1 0.99934 0.9993 vtnb vitronectin ------catalytic activity /// metal ion binding --- Dr.1347.1.S1_at 2.150553 3.838539 4.515285 6.20688 0.999955 0.029583 0.008292 0.004171 0.0042 rpl4 ribosomal p--- translation /// metabolic process structural constituent of ribosome /// oxidoreductase activity intracellular /// ribosome

Dr.13475.1.A1 at -2.13907 -2.41328 -3.23686 -2.50905 0.999955 0.987625 0.067271 0.168564 0.0673 ------Dr.1348.1.S1_at -1.20811 1.062567 2.496485 6.558258 1 1 0.354574 0.010357 0.0104 pcna proliferating --- DNA replication /// regulation of DNA replication /// response DNA binding /// DNA polymerase processivity factor activity nucleus /// nucleus /// PCNA complex to stress /// response to bacterium Dr.13481.1.S1 at -2.5763 -1.78104 -2.0468 -1.41765 0.876882 1 0.9997 1 0.8769 ------Dr.13487.1.S1 at -2.68837 -2.72491 -3.19712 -2.99205 0.85633 0.643252 0.377187 0.533732 0.3772 zgc:100896 zgc:100896------Dr.13487.2.A1 at -2.41437 -2.77454 -2.85495 -2.61597 0.813474 0.237071 0.217053 0.544 0.2171 LOC564797 similar to h ------Dr.13487.2.A1 x at -2.12312 -2.52456 -2.7641 -2.47707 0.998 0.169688 0.232411 0.667478 0.1697 LOC564797 similar to h ------Dr.13491.1.S1 at -1.38194 -1.91698 -1.3836 -2.20274 1 1 1 0.980602 0.9806 ------Dr.13492.1.S1 at -1.46105 -1.46568 -1.59954 -2.1148 1 1 1 0.972 0.972 ------Dr.13501.1.S1 at -1.32957 -1.76431 -1.62541 -2.46251 1 1 1 0.774535 0.7745 ------Dr.13504.1.S1 at 2.421043 3.136017 3.401265 3.598256 0.753679 0.23691 0.167945 0.122146 0.1221 btg3 B-cell trans------Dr.1351.1.S1_at 1.437653 2.786638 3.216953 4.788228 1 0.663 0.19357 0.083802 0.0838 zgc:65996 zgc:65996 --- translation structural constituent of ribosome intracellular /// ribosome /// large ribosomal subunit /// ribonucleoprotein complex

Dr.13517.1.S1 at 1.136652 2.316408 2.177089 2.549499 1 0.734625 0.91545 0.509857 0.5099 magoh mago-nash ------nucleus Dr.1353.1.S1_at 1.362022 2.563096 3.310049 4.029975 1 0.726173 0.023773 0.017277 0.0173 rpl11 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.13533.1.S1 at -2.2841 -2.75261 -2.38651 -3.02797 0.996 0.465 0.889651 0.667445 0.465 ------Dr.13536.1.A1 at -1.2087 -1.46754 -1.24672 -2.02435 1 1 1 0.9997 0.9997 ------Dr.13550.1.A1_at 1.628374 2.112177 1.855053 1.488892 1 0.974166 1 1 0.9742 cdipt CDP-diacy --- phospholipid biosynthetic process transferase activity /// phosphotransferase activity, for other membrane substituted phosphate groups Dr.13563.1.S1_at -1.6491 -2.09574 -1.34667 -2.12852 1 0.997562 1 0.991918 0.9919 metap2 methionyl a --- proteolysis /// cobalt ion transport /// Wnt receptor signaling aminopeptidase activity /// endopeptidase inhibitor activity /// cytoplasm pathway /// Wnt receptor signaling pathway /// protein peptidase activity /// metalloexopeptidase activity /// cobalt processing /// peptidyl-methionine modification /// N-terminal ion transmembrane transporter activity /// hydrolase activity protein amino acid modification /// metal ion binding /// cobalt ion binding

Dr.13565.1.A1 at 2.790629 4.042392 2.580659 2.409399 0.211148 0.038814 0.276869 0.199486 0.0388 wu:fc62b05 wu:fc62b05------Dr.1357.1.S1_at 1.479874 2.436038 2.697895 2.336976 1 0.06734 0.004594 0.043835 0.0046 cct8 chaperonin --- protein folding /// proteolysis /// cellular protein metabolic nucleotide binding /// aspartic-type endopeptidase activity /// cytoplasm process protein binding /// ATP binding /// unfolded protein binding

Dr.13585.1.A1 at -1.459 -1.64249 -1.46934 -2.07763 1 1 1 0.992624 0.9926 ------Dr.13586.1.A1 at -1.30398 -1.16479 -1.17347 5.028231 1 1 1 0.092259 0.0923 LOC567366 similar to P------Dr.1360.1.S1_at 1.493696 2.652703 3.153903 3.566368 1 0.129611 0.00859 0.007488 0.0075 rps9 ribosomal p--- translation RNA binding /// structural constituent of ribosome /// rRNA intracellular /// ribosome /// small ribosomal binding subunit /// ribonucleoprotein complex

Dr.13609.1.A1 at -8.90991 -9.49033 -4.21011 -10.182 0.776214 0.757524 0.994295 0.734853 0.7349 ------Dr.13609.2.S1 at -5.13143 -5.52546 -4.13948 -5.60294 0.825807 0.798838 0.958399 0.803 0.7988 ------Dr.1361.1.S1 at -1.57158 -1.67189 -1.82189 -2.12821 1 1 1 0.99934 0.9993 zgc:153629 zgc:153629------structural molecule activity intermediate filament Dr.13623.1.S1 at 1.926764 3.477677 3.470545 3.845772 1 0.052679 0.168703 0.055413 0.0527 zgc:77241 zgc:77241 ------Dr.13632.1.S1 at 1.566603 2.31691 2.01602 2.433166 1 0.862692 1 0.04367 0.0437 DKEY-57A22.8 hypothetica------Dr.13635.1.S1 at 4.071484 6.588464 6.671323 7.249656 0.091582 0.016187 0.022516 0.023166 0.0162 nhp2l1 NHP2 non---- ribosome biogenesis --- ribonucleoprotein complex Dr.1366.1.S1_a_at 1.685841 2.308157 2.088792 1.917701 1 0.517963 0.937927 1 0.518 ap3s1 adaptor-rela--- transport /// intracellular protein transport /// protein protein binding /// protein transporter activity membrane coat transport /// vesicle-mediated transport Dr.13660.1.S1 at 1.325276 -1.196 -2.50834 -1.49894 1 1 0.936639 1 0.9366 DKEY-97K23.1 /// zgc:101hypothetica------Dr.13674.1.S1 at -1.72696 -1.66525 -1.34974 -2.60617 1 1 1 0.994659 0.9947 wu:fc92e03 wu:fc92e03------Dr.13677.1.S1_at 1.214085 2.099991 2.540939 2.523775 1 0.907435 0.427469 0.313313 0.3133 zgc:55317 zgc:55317 ------hydrolase activity, acting on carbon-nitrogen (but not --- peptide) bonds, in linear amidines /// metal ion binding Dr.1368.1.S1 a at 1.474068 2.861333 3.500046 4.477443 1 0.112829 0.016573 0.007822 0.0078 gnb2l1 guanine nu------Dr.1368.4.A1 at -1.16065 -1.28174 -2.36816 -1.21011 1 1 0.629897 1 0.6299 ------Dr.13682.1.S1 at -3.6644 -5.81951 -8.39979 -4.62138 0.298912 0.066562 0.039 0.040162 0.039 LOC100002387 Hypothetica------Dr.13684.2.A1_at 2.051047 1.766749 2.10899 2.96199 0.980893 1 0.942804 0.234447 0.2344 apaf1 apoptotic p--- apoptosis /// defense response /// regulation of apoptosis nucleotide binding /// endopeptidase inhibitor activity /// intracellular /// cytoplasm protein binding /// ATP binding /// peptidase activity Dr.13688.1.S1 at 2.182259 2.642499 2.465066 2.076043 0.655306 0.42997 0.467 0.816752 0.43 LOC792693 similar to C ------Dr.13688.2.A1 at 2.234167 2.755507 2.662174 2.251529 0.813318 0.364424 0.212462 0.891306 0.2125 LOC792693 similar to C ------Dr.13693.1.S1 at 1.728352 2.10592 2.324517 3.127897 1 0.995 0.849904 0.195296 0.1953 zgc:153377 zgc:153377--- translation RNA binding /// structural constituent of ribosome intracellular /// ribosome Dr.137.1.S1 at 2.297141 2.85856 3.028368 2.730089 0.779087 0.445781 0.288585 0.32067 0.2886 tomm22 translocase ------Dr.13705.1.A1 at 1.392657 1.940367 2.022119 2.283161 1 1 1 0.729385 0.7294 zgc:112305 zgc:112305--- transcription /// regulation of transcription DNA binding /// DNA-directed RNA polymerase activity --- Dr.13717.1.S1 at 1.456109 2.16043 2.447588 3.137481 1 0.885 0.617504 0.040211 0.0402 dnajc10 DnaJ (Hsp--- protein folding /// cell redox homeostasis heat shock protein binding /// unfolded protein binding endoplasmic reticulum Dr.1372.1.S1 at 4.642202 14.42769 15.81133 18.85224 0.343095 0.066128 0.052881 0.04659 0.0466 krt18 keratin 18 ------structural molecule activity intermediate filament Dr.13722.2.A1_at 1.91788 2.784521 2.265951 2.13066 1 0.855576 0.913 0.998 0.8556 psmg1 proteasome --- proteasome assembly /// proteasome assembly protein binding /// protein binding cytoplasm /// cytoplasm /// endoplasmic reticulum /// endoplasmic reticulum Dr.13731.1.S1 at 1.473551 2.693163 2.655745 2.092119 1 0.206064 0.698545 0.932376 0.2061 zgc:86811 zgc:86811 ------ATP binding --- Dr.13740.1.S1 at -1.27402 -1.2488 1.247653 12.67999 1 1 1 0.010112 0.0101 LOC569270 similar to a ------Dr.13747.1.S1 at 1.303046 2.692994 2.394042 1.44686 1 0.081378 0.494294 1 0.0814 pmm2 phosphoma--- metabolic process /// mannose biosynthetic process catalytic activity /// phosphomannomutase activity cytoplasm Dr.13749.1.A1 at 1.751723 2.430042 2.305339 1.894869 1 0.88031 0.895466 1 0.8803 zgc:110717 zgc:110717--- RNA processing 3'-5'-exoribonuclease activity /// RNA binding --- Dr.1375.1.S1_at -1.06676 1.811094 2.348449 2.578046 1 1 0.872327 0.083554 0.0836 LOC798942 /// psmc1a similar to P--- DNA replication initiation /// regulation of DNA replication /// nucleotide binding /// DNA binding /// DNA replication origin nucleus /// cytoplasm /// cytosol /// protein protein catabolic process binding /// ATP binding /// hydrolase activity /// nucleoside- complex triphosphatase activity Dr.13752.1.S1 at 1.88522 2.832252 3.224888 2.380039 1 0.420754 0.302706 0.748981 0.3027 smfn small fragm------nucleic acid binding /// exonuclease activity intracellular Dr.13754.1.S1 at 1.094678 2.116312 1.299305 -1.02508 1 0.967546 1 1 0.9675 uba5 ubiquitin-lik------Dr.13755.1.S1 at 1.221552 2.242013 2.231411 1.580364 1 0.961829 0.999325 1 0.9618 ------Dr.13756.1.S1 at -1.90842 -2.38296 -1.70567 -2.60276 1 0.971561 1 0.813474 0.8135 ------Dr.13763.1.S1 at 1.824145 2.346838 2.160701 2.683077 1 0.893475 0.999 0.517744 0.5177 zgc:103459 zgc:103459--- translation structural constituent of ribosome intracellular /// ribosome Dr.13775.1.S1 at 2.22811 2.128608 1.955027 2.405044 0.942588 0.996 1 0.787561 0.7876 zgc:153059 zgc:153059------nucleic acid binding /// zinc ion binding --- Dr.1378.1.S1_at 2.906554 2.187656 1.84975 2.319055 0.374468 0.823 1 0.575248 0.3745 gadd45b growth arre--- somitogenesis /// somitogenesis /// response to cadmium ------ion /// response to methylmercury Dr.13783.1.A1 at -1.55305 -1.73719 -2.40535 -1.78305 1 1 0.948881 1 0.9489 LOC563797 similar to C------Dr.13785.1.A1 at -1.71704 -2.26091 -1.59891 -2.1631 1 0.962505 1 0.961976 0.962 ------Dr.13789.1.A1 at -4.69197 -6.88997 -5.26684 -4.15069 0.115884 0.086522 0.095331 0.173792 0.0865 CH211-254N4.3 novel prote------Dr.13809.1.S1 at 1.893379 2.898506 2.965767 2.605617 1 0.138387 0.116556 0.019252 0.0193 zgc:112501 zgc:112501--- transcription DNA binding /// DNA-directed RNA polymerase activity nucleus Dr.13817.1.A1 at -1.74213 -2.1772 -1.53917 -2.98393 1 0.892 1 0.39 0.39 ------Dr.13821.1.A1 at -1.62469 -1.73903 -1.3632 -2.2221 1 1 1 0.853 0.853 ------Dr.13827.1.A1 at 1.767956 2.090239 1.572518 1.874895 1 0.958708 1 1 0.9587 smap1 stromal me --- regulation of ARF GTPase activity ARF GTPase activator activity /// zinc ion binding --- Dr.1383.1.S1_at 1.698538 2.398218 2.357895 2.514653 1 0.311183 0.418094 0.215681 0.2157 hsp90ab1 heat shock --- protein folding /// response to stress nucleotide binding /// protein binding /// ATP binding /// cytoplasm unfolded protein binding Dr.13833.1.S1 at -1.63703 -1.87808 -1.42166 -2.43554 1 1 1 0.512799 0.5128 ------Dr.13835.1.A1 at -1.49573 -1.70463 -1.31604 -2.29578 1 1 1 0.797 0.797 ------Dr.13837.1.A1 at -1.38985 -1.68086 -2.44763 -2.32276 1 1 0.447744 0.591308 0.4477 ------Dr.13840.1.A1 at 1.395519 3.112694 2.65719 1.321558 1 0.228252 0.363453 1 0.2283 ------Dr.13848.1.A1 at -1.15279 -2.21476 -2.51141 -2.18354 1 0.994295 0.793364 0.98838 0.7934 ------Dr.13852.1.A1 at -1.61712 -1.86846 -1.56024 -2.25511 1 1 1 0.678 0.678 ------Dr.13858.1.A1 at -1.13237 -1.72789 -2.36523 -1.6616 1 1 0.147149 1 0.1471 ------Dr.13868.1.S1 at 4.974015 15.23118 10.70726 7.149457 0.151326 0.012083 0.023486 0.026207 0.0121 syt4 synaptotag--- transport transporter activity synaptic vesicle /// membrane Dr.13875.1.A1 at 2.484116 3.015198 1.731142 1.385082 0.874 0.076493 1 1 0.0765 ------Dr.1388.1.S1 at 2.240239 2.976055 3.297295 2.933005 0.610446 0.087206 0.082581 0.139119 0.0826 gspt1 G1 to S ph------nucleotide binding /// GTPase activity /// GTP binding --- Dr.13889.1.A1 at -1.92254 -2.46147 -1.74916 -2.68722 1 0.768696 1 0.640498 0.6405 ------Dr.13890.1.A1 at -1.8387 -2.32284 -1.5178 -2.95279 1 0.750323 1 0.317 0.317 ------Dr.139.1.S1_at 4.389487 4.448738 4.870972 4.715911 0.021061 0.014442 0.007775 0.010512 0.0078 tgif1 TGFB-indu--- regulation of transcription, DNA-dependent /// forebrain DNA binding /// transcription factor activity /// sequence- nucleus anterior/posterior pattern formation /// regulation of specific DNA binding transcription /// regulation of retinoic acid receptor signaling pathway /// brain morphogenesis Dr.13902.1.S1 at -1.05685 -1.85945 -3.39896 -2.76814 1 1 0.377873 0.615 0.3779 LOC100150563 similar to s------Dr.13918.1.S1 at 1.20671 -1.8862 -1.58519 -2.20255 1 1 1 0.99556 0.9956 ------Dr.13920.1.A1 at -1.64498 -2.61969 -3.61133 -2.39735 1 0.494294 0.250242 0.728594 0.2502 lhfpl3 lipoma HMG------membrane /// integral to membrane Dr.13933.1.A1 at -1.14673 -1.43575 -2.32098 -1.92373 1 1 0.855387 1 0.8554 ------Dr.13934.1.S1 at -1.89189 -2.64058 -3.59694 -2.14185 1 0.938303 0.751226 0.999955 0.7512 ------Dr.13952.1.A1_at -1.96374 -1.60165 -2.36655 -1.90611 1 1 0.820119 1 0.8201 zgc:63553 zgc:63553 --- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein binding /// --- hydrolase activity /// phosphatase activity Dr.13962.1.S1 at 1.085368 -1.22785 1.157847 2.350695 1 1 1 0.787796 0.7878 gins3 GINS comp------Dr.13970.1.S1 at -2.28933 -3.27779 -3.28747 1.155068 0.604653 0.177806 0.070859 1 0.0709 arl4a ADP-ribosy--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.13981.1.A1 at -1.45566 -1.89179 -1.28955 -2.02431 1 1 1 0.99934 0.9993 ------Dr.13982.1.A1_at 1.811336 2.347143 2.575547 2.987165 1 0.952845 0.549409 0.332606 0.3326 zgc:171911 zgc:171911--- translation structural constituent of ribosome intracellular /// ribosome /// large ribosomal subunit Dr.13984.1.A1 at -1.98951 -1.79933 -1.4978 -2.30619 1 1 1 0.912151 0.9122 ------Dr.13989.1.S1 at -2.04869 -2.31422 -1.84568 -3.02385 0.9997 0.858431 1 0.281815 0.2818 ing5a inhibitor of --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.13994.2.A1 a at 1.531315 1.725558 1.936716 2.385716 1 1 1 0.682546 0.6825 phpt1 phosphohis------Dr.13996.1.A1 at -1.65702 -1.85015 -1.9351 -2.11393 1 1 1 0.999 0.999 zp3c zona pelluc------Dr.1400.1.S1 at 1.104508 3.416015 4.656915 6.824359 1 0.272 0.04522 0.012744 0.0127 zgc:77702 zgc:77702 --- translation structural constituent of ribosome intracellular /// ribosome Dr.14001.2.S1 at -1.73332 -1.90376 -1.63717 -2.39252 1 1 1 0.917592 0.9176 pttg1ip pituitary tum------Dr.14011.1.S1 at 2.250083 3.887011 4.316805 4.446668 0.9648 0.080997 0.049863 0.124565 0.0499 LOC572231 hypothetica--- protein folding unfolded protein binding prefoldin complex Dr.14017.1.A1 at 2.470229 3.564325 3.812393 3.177738 0.32423 0.040988 0.032213 0.03147 0.0315 zgc:100967 zgc:100967------Dr.14021.1.A1_at 1.275751 1.839191 1.949139 2.201689 1 1 1 0.937 0.937 hibadhb 3-hydroxyis--- pentose-phosphate shunt /// valine metabolic process /// catalytic activity /// phosphogluconate dehydrogenase --- metabolic process (decarboxylating) activity /// binding /// 3-hydroxyisobutyrate dehydrogenase activity /// oxidoreductase activity /// coenzyme binding /// NAD binding

Dr.14021.3.A1_at 1.032733 1.835078 2.15208 2.215915 1 1 0.994977 0.923513 0.9235 hibadhb 3-hydroxyis--- pentose-phosphate shunt /// valine metabolic process /// catalytic activity /// phosphogluconate dehydrogenase --- metabolic process (decarboxylating) activity /// binding /// 3-hydroxyisobutyrate dehydrogenase activity /// oxidoreductase activity /// coenzyme binding /// NAD binding

Dr.14024.1.S1 at 1.665833 1.607203 2.014697 2.310693 1 1 1 0.983791 0.9838 zgc:56709 zgc:56709 ------heat shock protein binding --- Dr.14033.1.A1 at -1.32157 -1.54921 -3.50502 -2.49842 1 1 0.32723 0.671788 0.3272 LOC795519 similar to S------Dr.14043.1.A1 at 1.340758 2.285923 3.14068 3.376384 1 0.945384 0.542478 0.330271 0.3303 LOC568426 similar to s ------Dr.14049.1.S1 at -1.29422 -1.77267 -2.02209 -1.81401 1 1 0.957754 1 0.9578 zgc:158667 zgc:158667--- coenzyme A biosynthetic process pantothenate kinase activity /// ATP binding --- Dr.14050.1.A1 at -1.75608 -2.11305 -1.21797 -2.61316 1 0.984 1 0.705216 0.7052 ------Dr.14051.1.A1 at -1.43628 -1.98969 -1.60108 -2.57708 1 0.99994 1 0.724487 0.7245 wu:fq14a08 wu:fq14a08------Dr.14063.1.A1_at -1.83015 -2.6071 -2.98755 -2.04682 1 0.22146 0.034335 0.994816 0.0343 eml2 echinoderm --- regulation of transcription, DNA-dependent /// signal ------transduction Dr.14064.1.S1 at -5.76664 -6.114 -4.99275 -4.76585 0.168105 0.175 0.23809 0.332788 0.1681 zgc:55418 zgc:55418 ------Dr.14069.1.A1 at 1.052409 -1.36464 -2.27066 -1.97171 1 1 0.880907 0.999 0.8809 ------Dr.14075.1.A1 at -3.614 -1.76594 -2.19572 -2.00448 0.059763 1 0.358453 0.996 0.0598 si:ch211-63o20.5 si:ch211-63------nucleic acid binding /// zinc ion binding intracellular Dr.14076.1.A1 at 1.624623 2.909671 2.412366 1.229451 1 0.233886 0.673672 1 0.2339 ------Dr.14079.1.S1_at 1.422337 1.483276 1.616565 3.149489 1 1 1 0.208542 0.2085 ywhai tyrosine 3-m------monooxygenase activity /// protein domain specific binding ---

Dr.14084.1.S1 at -1.19254 -1.52341 -1.28544 -2.0965 1 1 1 0.995813 0.9958 ------Dr.1410.1.S1_at 1.153708 2.18291 3.005238 2.71313 1 1 0.615 0.3905 0.3905 prrx1 paired relat--- regulation of transcription, DNA-dependent /// multicellular DNA binding /// transcription factor activity /// sequence- nucleus organismal development /// regulation of transcription specific DNA binding

Dr.14100.1.S1 at -1.28948 -2.27386 -2.78281 -1.93861 1 0.948521 0.674584 1 0.6746 ------Dr.14110.1.A1_at -1.01855 1.49307 2.123087 3.316509 1 1 0.996552 0.755903 0.7559 zgc:73262 zgc:73262 --- translation /// zinc ion transport structural constituent of ribosome /// zinc ion binding /// intracellular /// ribosome /// ribonucleoprotein metal ion binding complex Dr.14117.1.S1 at 1.366134 1.794168 1.768714 2.220954 1 1 1 0.949741 0.9497 cd2bp2 CD2 antige------Dr.1412.1.S1_at -1.03026 1.802939 1.99744 2.423593 1 1 1 0.807402 0.8074 ywhae1 tyrosine 3-m------monooxygenase activity /// protein domain specific binding ---

Dr.1412.2.A1 at 1.458427 2.778697 3.437785 2.237075 1 0.275 0.123614 0.76275 0.1236 zgc:109901 zgc:109901------nucleus Dr.14129.1.A1 at 1.097417 -1.22573 -2.44176 -1.37561 1 1 0.690581 1 0.6906 ------Dr.14132.1.S1 at -2.28303 -2.35833 -1.54313 -3.04614 0.96775 0.831525 1 0.422191 0.4222 ------Dr.14133.1.A1_at 1.152702 1.52426 1.58077 5.691418 1 1 1 0.316468 0.3165 zgc:92463 zgc:92463 --- potassium ion transport ion channel activity /// voltage-gated potassium channel voltage-gated potassium channel complex /// activity /// protein binding membrane Dr.14134.1.S1 at -1.58347 -2.12568 -1.72313 -2.67905 1 0.975582 1 0.331132 0.3311 ------Dr.14154.1.S1 at 1.3864 1.717217 1.780165 2.335226 1 1 1 0.993 0.993 zgc:73375 zgc:73375 ------Dr.14164.1.A1 at -5.1359 -4.8336 -5.18985 -4.59298 0.092259 0.055423 0.102766 0.063287 0.0554 ------Dr.14167.1.S1 at -1.38114 -1.67809 -1.20694 -2.00459 1 1 1 0.999917 0.9999 ------Dr.14169.1.A1_at -1.21714 -2.08285 -2.60943 -2.3372 1 0.996244 0.772289 0.938614 0.7723 slc25a32a solute carri--- transport /// mitochondrial transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.14172.1.S1 at -1.59123 -1.78369 -1.49889 -2.6661 1 1 1 0.884985 0.885 ------Dr.14184.1.A1 at -1.68442 -1.86738 -1.87334 -2.15808 1 1 1 0.99321 0.9932 ------Dr.14203.1.S1 at -1.90623 -2.38132 -3.25296 -2.55714 1 0.591443 0.019536 0.167736 0.0195 ppp1r14a protein pho--- regulation of phosphorylation protein binding cytoplasm Dr.14208.1.A1_at -1.05094 -1.40566 -2.04693 -1.64495 1 1 0.999 1 0.999 gpsn2 Glycoprote--- lipid metabolic process oxidoreductase activity, acting on the CH-CH group of cytoplasm /// integral to membrane donors Dr.14208.1.A1_s_at -1.32378 -1.73051 -2.24395 -1.88845 1 1 0.46969 1 0.4697 gpsn2 glycoprotei--- lipid metabolic process oxidoreductase activity, acting on the CH-CH group of cytoplasm /// integral to membrane donors Dr.14221.1.S1_at -1.50409 -2.01242 -1.44882 -2.10234 1 0.997562 1 0.992 0.992 efr3a EFR3 hom--- methylation nucleic acid binding /// binding /// methyltransferase activity ---

Dr.14223.1.S1 at 2.143005 2.702565 2.484848 2.193625 0.88 0.093926 0.209 0.279152 0.0939 DKEY-175C11.1 Hypothetica------Dr.14224.1.A1 at -1.71101 -1.97626 -1.37012 -2.1792 1 0.999955 1 0.929974 0.93 ------Dr.14228.1.S1 at 2.213413 4.331857 4.848014 4.666385 0.869633 0.020712 0.052812 0.031185 0.0207 zgc:103688 zgc:103688--- mRNA metabolic process --- ribonucleoprotein complex Dr.14234.2.A1 at 1.727859 2.849596 3.564365 2.930581 1 0.307407 0.118815 0.258246 0.1188 zgc:86755 zgc:86755 --- transport --- membrane /// integral to membrane Dr.14240.1.A1 at -1.45716 -1.60532 -1.29023 -2.09494 1 1 1 0.982587 0.9826 ------Dr.14248.1.A1 at -1.06211 1.53834 2.408576 2.171561 1 1 0.638306 0.971702 0.6383 wu:fj11d04 wu:fj11d04 ------Dr.1425.1.S1_at 1.591442 2.906411 3.359463 4.234997 1 0.115665 0.046129 0.016428 0.0164 rpl23a ribosomal p--- translation nucleotide binding /// RNA binding /// structural constituent intracellular /// ribosome /// ribonucleoprotein of ribosome complex Dr.14261.1.A1 at 2.913582 4.154062 4.111537 4.018445 0.450323 0.088144 0.09638 0.088183 0.0881 zgc:123178 zgc:123178------Dr.14261.3.S1 at -1.76735 -2.82252 -2.49596 -1.69444 1 0.243731 0.313905 1 0.2437 ------Dr.14262.1.A1_a_at 1.090422 1.806605 1.805138 2.393524 1 1 1 0.607948 0.6079 zgc:66253 zgc:66253 --- tricarboxylic acid cycle /// fumarate metabolic process catalytic activity /// fumarate hydratase activity /// mitochondrion /// tricarboxylic acid cycle activity enzyme complex Dr.14269.1.A1 at -1.87959 -1.83622 -1.75307 -2.30222 1 1 1 0.972 0.972 tmf1 TATA elem------Dr.14273.1.A1_at 1.470277 1.985378 2.124011 2.843154 1 1 0.957967 0.188095 0.1881 si:ch211-85e10.6 si:ch211-85--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.1428.1.S1_at 1.307787 2.547164 3.321453 4.077122 1 0.824228 0.197875 0.09664 0.0966 rps15a ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.14282.1.S1_at 5.652687 3.01052 3.026918 3.345293 0.073646 0.597 0.614785 0.288254 0.0736 atf3 activating tr--- regulation of transcription, DNA-dependent /// response to DNA binding /// transcription factor activity /// sequence- nucleus virus specific DNA binding /// protein dimerization activity

Dr.14286.1.A1 at -1.41204 -1.57766 -1.38983 -2.13003 1 1 1 0.975776 0.9758 wu:fc03g10 wu:fc03g10------Dr.1429.1.S1 at 1.34345 1.533608 1.637896 2.439015 1 1 1 0.795461 0.7955 ------Dr.14292.1.S1 at 1.747355 2.9376 2.770193 3.677345 1 0.447509 0.646511 0.280497 0.2805 zgc:73351 zgc:73351 ------DNA binding /// sequence-specific DNA binding intracellular Dr.14293.1.S1 at 1.366347 2.118498 2.13213 1.912122 1 0.864834 0.991488 1 0.8648 tomm40 translocase --- anion transport voltage-gated anion channel activity mitochondrial outer membrane Dr.1430.1.S1 at 1.365411 1.8998 2.205383 3.210538 1 1 0.911679 0.165335 0.1653 zgc:194876 zgc:194876------Dr.14310.1.A1 at -1.78336 -2.37668 -1.77138 -2.8304 1 0.585 1 0.500347 0.5003 wu:fd47e12 wu:fd47e12------Dr.14314.1.A1 at 1.259775 2.050412 2.00574 1.808157 1 0.962 1 1 0.962 zgc:194819 zgc:194819------Dr.14317.1.A1 at -1.24536 -1.78878 -2.04789 -1.62513 1 1 0.98 1 0.98 ------Dr.14319.1.A1 at -2.05533 -4.59248 -5.16391 -3.51366 0.973527 0.080175 0.033336 0.064545 0.0333 zgc:175209 zgc:175209--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular /// membrane Dr.1432.1.S1 a at 1.441881 2.285626 2.580786 3.079464 1 0.821 0.13948 0.041735 0.0417 rpl35a ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.14327.1.A1 at 2.02466 -1.32399 -1.63547 -1.54125 0.998 1 1 1 0.998 ------Dr.14331.1.S1_at 2.671232 5.227122 5.258013 5.380576 0.910449 0.109801 0.064 0.05373 0.0537 wars tryptophany--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity /// ATP binding /// ligase activity Dr.14336.1.A1 at -3.07204 -5.58301 -5.69048 -4.67279 0.370605 0.031981 0.022062 0.100793 0.0221 zgc:73275 zgc:73275 ------structural molecule activity intermediate filament Dr.14340.2.S1 a at -1.2782 -1.65388 -2.33221 -1.85158 1 1 0.620304 1 0.6203 ------Dr.14349.1.S1 at -5.51257 -5.05864 -5.70039 -5.10095 0.053147 0.04648 0.034335 0.053147 0.0343 ------Dr.14364.1.A1 at 1.680773 4.287327 10.20393 11.37227 1 0.017812 0.009757 0.00814 0.0081 ------Dr.14374.1.A1 at -1.33373 -1.33776 -2.83435 -2.13038 1 1 0.577736 0.986 0.5777 gadd45a growth arre------Dr.14376.1.A1 at -1.73496 -2.0734 -1.70073 -1.67767 1 0.990731 1 1 0.9907 LOC100000908 /// LOC10similar to S ------Dr.1438.1.S1 at -1.96061 1.302752 1.692272 12.6374 1 1 1 0.016674 0.0167 dUTP pyro --- dUTP metabolic process dUTP diphosphatase activity /// hydrolase activity --- Dr.14390.1.S1 at 1.806776 3.276236 2.513309 2.017835 1 0.035692 0.498389 1 0.0357 ------Dr.1441.1.S1 at 1.368952 2.305858 2.679273 3.222963 1 0.87365 0.369278 0.174201 0.1742 zgc:123327 zgc:123327--- translation structural constituent of ribosome intracellular /// ribosome Dr.14411.1.S1 at 1.762187 2.950778 3.370735 3.075631 1 0.635 0.302706 0.368 0.3027 zgc:110606 zgc:110606------nucleotide binding /// nucleic acid binding --- Dr.14449.1.A1 at -1.70502 -2.05772 -1.52944 -1.70026 1 0.999 1 1 0.999 LOC792834 similar to p------Dr.14453.1.A1 at -1.39061 -1.44601 -1.41683 -2.1247 1 1 1 0.998961 0.999 ------Dr.14466.1.S1 at -1.87508 -1.91873 -1.8997 -2.26002 1 1 1 0.99934 0.9993 ------Dr.14472.1.A1 at -1.81312 -2.16978 -2.50341 -2.71443 1 0.999955 0.997322 0.994696 0.9947 aplp2 amyloid bet------serine-type endopeptidase inhibitor activity /// binding integral to membrane Dr.14477.1.S1_at -1.07713 3.284676 2.753841 2.578568 1 0.325991 0.747252 0.737 0.326 ssr4 signal sequ------receptor activity endoplasmic reticulum /// integral to membrane Dr.14490.1.A1 at 2.313264 3.928434 3.871014 4.178751 0.84 0.048336 0.040167 0.021906 0.0219 zgc:162640 zgc:162640------Dr.1450.1.S1_at -1.76443 -2.01621 -1.81102 -3.07361 1 0.999955 1 0.348657 0.3487 hbae3 hemoglobin --- heme biosynthetic process /// transport /// iron ion transport oxygen transporter activity /// iron ion binding /// oxygen hemoglobin complex /// cellular iron ion homeostasis /// oxygen transport binding /// heme binding /// metal ion binding

Dr.14504.1.S1 at 1.620093 2.018997 2.31288 3.19045 1 1 0.704255 0.283632 0.2836 zgc:171480 zgc:171480------ribosome Dr.1452.1.S1 at 1.537121 1.848693 2.070109 2.918081 1 1 1 0.211 0.211 zgc:86599 zgc:86599 ------cytochrome-c oxidase activity mitochondrial envelope Dr.14530.1.S1 at 1.224301 3.360936 3.612862 3.189094 1 0.047357 0.074145 0.076723 0.0474 zgc:110652 zgc:110652------Dr.14548.1.A1 at -1.77132 -2.3046 -2.01806 -2.27546 1 0.718548 1 0.745583 0.7185 zranb1 zinc finger, ------zinc ion binding intracellular Dr.1455.1.S1 at 1.091373 2.277001 3.050444 5.094049 1 0.987944 0.162579 0.039614 0.0396 fau Finkel-Bisk--- translation /// protein modification process structural constituent of ribosome intracellular /// ribosome Dr.14552.1.S1 at -1.25692 -1.27193 -1.00208 2.765626 1 1 1 0.220071 0.2201 ift46 intraflagella--- determination of ventral identity ------Dr.14555.1.S1 at -2.19402 -1.7654 -1.71227 -2.45085 0.999955 1 1 0.996637 0.9966 ivns1abpa influenza vi------protein binding nucleus /// cytoplasm /// cytoskeleton Dr.14559.1.S1 at -1.85684 -2.03363 -2.20746 -2.30373 1 1 0.999955 0.9997 0.9997 ------Dr.14564.1.A1 at -1.88936 -1.93427 -1.84278 -2.33428 1 1 1 0.835 0.835 ------Dr.14574.1.A1 at 3.051572 2.967001 2.619624 2.45736 0.111125 0.246762 0.451472 0.584389 0.1111 ------Dr.14576.1.S1 at -1.80668 -3.20266 -6.33954 -6.83237 1 0.6 0.218286 0.106517 0.1065 sncgb synuclein, g------cytoplasm Dr.14576.2.S1 at -2.16895 -3.3117 -6.2698 -6.82492 1 0.773 0.259 0.252622 0.2526 sncgb synuclein, g------cytoplasm Dr.14576.3.A1 at -1.80719 -3.05601 -4.65084 -5.15577 1 0.908217 0.459716 0.404 0.404 sncgb Synuclein, ------cytoplasm Dr.14577.1.A1_at -2.52001 -2.17306 -3.00617 -2.50893 0.165 0.918 0.139436 0.711513 0.1394 zgc:92090 zgc:92090 --- transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.14595.1.A1 at -2.46186 -2.79615 -3.04921 -2.53821 0.581124 0.440241 0.25954 0.61089 0.2595 ------Dr.14599.1.A1 at 1.203091 1.326832 1.242547 12.10241 1 1 1 0.019968 0.02 ------Dr.14605.1.A1 at -1.59116 -1.69754 -1.4157 -2.0687 1 1 1 0.99321 0.9932 ------Dr.14614.1.A1 at -1.35566 -1.97636 -2.04801 -1.87659 1 0.9997 0.998961 1 0.999 ------Dr.14635.1.A1_at -1.31125 -1.27562 -1.55728 2.174274 1 1 1 0.936639 0.9366 cdc14b CDC14 cel --- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein --- /// cell division tyrosine/serine/threonine phosphatase activity /// hydrolase activity /// phosphatase activity Dr.14641.1.A1 at 1.896542 2.32802 1.920414 1.952922 1 0.82222 1 1 0.8222 ------Dr.14645.1.A1 at -2.31897 -1.36145 -1.70808 -1.40223 0.991736 1 1 1 0.9917 ------Dr.14648.1.A1 at -1.9777 -1.99014 -1.69887 -2.51626 1 1 1 0.85 0.85 ------Dr.14649.1.A1_at 1.498345 2.305242 2.467936 3.161772 1 0.996552 0.883942 0.383665 0.3837 zgc:110673 zgc:110673--- translation /// translation RNA binding /// structural constituent of ribosome /// intracellular /// mitochondrion /// ribosome /// structural constituent of ribosome small ribosomal subunit /// cytosolic small ribosomal subunit /// ribonucleoprotein complex Dr.14654.1.S1_at -1.24795 1.071246 -1.05892 2.839594 1 1 1 0.178274 0.1783 zgc:114060 zgc:114060--- post-translational protein modification /// regulation of ligase activity /// small conjugating protein ligase activity --- protein metabolic process Dr.14663.1.A1 at -6.20728 -4.9027 -6.40036 -4.28971 0.091842 0.084955 0.00759 0.028425 0.0076 ------Dr.14671.1.S1 at -1.35523 -1.09293 -1.09012 5.345606 1 1 1 0.112109 0.1121 birc5a baculoviral --- angiogenesis /// blood vessel morphogenesis --- intracellular Dr.14676.1.A1 at -1.5224 -2.21851 -1.48012 -2.55989 1 0.959 1 0.123724 0.1237 ------Dr.14687.1.A1_at 1.978726 2.093348 1.70515 1.973976 1 0.993617 1 0.998 0.9936 copb2 coatomer p--- intracellular protein transport /// vesicle-mediated transport structural molecule activity /// protein binding membrane coat /// notochord development Dr.14688.1.S1 at -1.59358 -1.92596 -2.41274 -1.77164 1 1 0.440142 1 0.4401 ppt1 palmitoyl-p--- protein modification process palmitoyl-(protein) hydrolase activity --- Dr.14705.1.S1 at 1.306994 1.786899 1.734174 2.500966 1 1 1 0.603602 0.6036 arpp19b cAMP-regu------Dr.14718.1.A1_at 2.153273 5.052898 3.763991 2.9135 0.994696 0.052613 0.08673 0.172789 0.0526 supt3h suppressor --- transcription from RNA polymerase II promoter DNA binding /// RNA polymerase II transcription factor transcription factor complex activity Dr.14719.1.A1 at 1.148044 1.549585 1.325575 2.808341 1 1 1 0.323273 0.3233 zgc:112199 zgc:112199--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.14726.1.S1_a_at -1.9282 -1.75372 -1.22528 -2.16334 1 1 1 0.999 0.999 zgc:162603 zgc:162603--- proteolysis catalytic activity /// metalloendopeptidase activity /// zinc ion --- binding /// metal ion binding Dr.14727.1.A1_at 2.362735 2.631554 2.03125 2.141135 0.895466 0.55023 1 0.998 0.5502 zgc:158305 zgc:158305------1-phosphatidylinositol 4-kinase activity /// kinase activity /// cytoplasm /// membrane transferase activity /// phosphotransferase activity, alcohol group as acceptor Dr.14768.1.A1_at -2.65811 -2.73141 -2.94491 -2.51415 0.980893 0.952481 0.962 0.98777 0.9525 mical3 flavoprotein --- cellular aromatic compound metabolic process /// zinc ion monooxygenase activity /// zinc ion binding /// --- transport /// metabolic process oxidoreductase activity /// metal ion binding Dr.14779.1.S1_at 1.314088 2.262869 2.359103 2.026568 1 0.994696 0.975582 0.999955 0.9756 zgc:112362 zgc:112362--- translation /// apoptosis /// cell cycle structural constituent of ribosome mitochondrion /// mitochondrial large ribosomal subunit /// ribosome /// ribonucleoprotein complex /// ribonucleoprotein complex

Dr.14782.1.A1 at 2.645874 1.071312 -1.07372 -1.1591 0.92 1 1 1 0.92 ------Dr.14787.1.A1 at -5.76008 -7.91396 -8.50632 -7.88141 0.205223 0.116556 0.094107 0.11858 0.0941 s100b S100 calciu------calcium ion binding --- Dr.1481.1.A1_at 2.027877 3.076353 2.774506 2.26013 0.982587 0.026156 0.116441 0.198674 0.0262 vars valyl-tRNA --- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// valine- cytoplasm valyl-tRNA aminoacylation tRNA ligase activity /// ATP binding /// ligase activity

Dr.14812.1.S1_at 1.894176 2.546925 2.278852 2.325775 1 0.613 0.978746 0.057373 0.0574 si:dkey-261i16.3 si:dkey-261--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.14817.1.A1 at 2.067652 1.092944 -1.3144 -1.19393 0.998 1 1 1 0.998 grik1a glutamate r------Dr.14818.1.A1_at 2.268842 4.034829 4.212621 3.199114 0.580513 0.180484 0.032 0.132213 0.032 zgc:110825 zgc:110825--- transcription /// transcription termination /// regulation of nucleic acid binding /// DNA binding /// DNA-directed RNA --- transcription, DNA-dependent /// zinc ion transport /// polymerase activity /// zinc ion binding /// transcription transcription antitermination /// regulation of transcription regulator activity /// metal ion binding

Dr.14819.1.S1 at 1.683841 2.594776 2.930638 3.136531 1 0.458196 0.173519 0.113 0.113 zgc:56424 zgc:56424 --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.14829.1.A1_at -1.69589 -1.53729 -1.85953 -2.90099 1 1 1 0.282354 0.2824 gcdhl glutaryl-Co--- metabolic process acyl-CoA dehydrogenase activity /// electron carrier activity --- /// oxidoreductase activity /// oxidoreductase activity, acting on the CH-CH group of donors /// FAD binding

Dr.14831.2.A1 at -2.12635 -2.16236 -1.67151 -2.10469 0.99994 0.983712 1 0.999955 0.9837 tp53bp2 tumor prote------Dr.14834.1.A1 at 1.178165 1.838671 2.357801 2.735826 1 1 0.739302 0.28432 0.2843 zgc:101136 zgc:101136--- mRNA metabolic process --- ribonucleoprotein complex Dr.14838.1.A1 at -1.75817 -1.90518 -1.6267 -2.01318 1 1 1 0.9997 0.9997 ------Dr.14849.1.S1 at 1.369897 2.589569 3.114615 2.866867 1 0.56 0.274 0.368668 0.274 zgc:103624 zgc:103624------calcium ion binding --- Dr.14854.1.S1 at 2.706514 3.804663 3.980467 3.297133 0.572931 0.22795 0.151326 0.267911 0.1513 zgc:92910 zgc:92910 ------nucleus Dr.14865.1.A1 at 1.496761 2.285254 2.031959 1.358545 1 0.922 1 1 0.922 si:ch73-52e5.2 si:ch73-52e------Dr.14868.1.S1 at -1.21917 -1.05127 1.361453 2.209917 1 1 1 0.820801 0.8208 zgc:103699 zgc:103699------protein binding --- Dr.14874.1.A1 at -1.97921 -2.39538 -2.58777 -2.86401 0.999955 0.763503 0.813474 0.557898 0.5579 ------Dr.14881.1.A1 at 2.413804 3.293426 3.011301 3.065193 0.093448 0.030378 0.382813 0.049068 0.0304 si:ch211-103f16.2 si:ch211-10------nucleotide binding /// nucleic acid binding --- Dr.14883.1.S1_at 3.612831 5.584049 6.004092 5.063782 0.065802 0.013173 0.012532 0.013964 0.0125 LOC100149346 similar to n--- rRNA processing /// ribosome biogenesis RNA binding /// rRNA binding nucleus /// small nucleolar ribonucleoprotein complex /// ribonucleoprotein complex

Dr.14906.1.A1 at 1.85696 2.518129 2.686996 2.673103 1 0.110549 0.190096 0.093796 0.0938 zgc:153390 zgc:153390--- translation structural constituent of ribosome intracellular /// ribosome Dr.1491.1.S1 at 1.089108 2.034331 2.153702 2.536525 1 0.999955 0.9648 0.243914 0.2439 zgc:112535 zgc:112535--- glycine catabolic process lipoic acid binding glycine cleavage complex Dr.14916.1.A1_at 1.225003 1.729725 2.075017 2.020906 1 1 0.996557 0.99994 0.9966 nudt2 nudix (nucl------bis(5'-nucleosyl)-tetraphosphatase activity /// hydrolase --- activity Dr.14926.1.A1 at 2.499808 2.676876 2.363237 1.991522 0.532476 0.539 0.931881 1 0.5325 ------Dr.14927.1.S1_at 2.900661 3.09588 2.717432 1.57971 0.414541 0.12579 0.439496 1 0.1258 oprs1 opioid rece--- ergosterol biosynthetic process /// transport /// lipid transport C-8 sterol isomerase activity /// receptor activity nucleus /// nuclear inner membrane /// nuclear outer membrane /// endoplasmic reticulum /// endoplasmic reticulum membrane /// plasma membrane /// membrane /// integral to membrane Dr.14931.1.S1 at 2.126693 3.826073 2.698769 2.473367 0.961855 0.097 0.48268 0.723712 0.097 zgc:153327 zgc:153327------nucleic acid binding --- Dr.14944.1.A1 at 2.004707 1.986149 1.032311 1.111352 0.996637 0.999955 1 1 0.9966 LOC555662 similar to M------Dr.14948.1.S1 at -1.87345 -1.78909 -1.85776 -2.31725 1 1 1 0.836606 0.8366 ------Dr.14950.1.A1 at -1.4272 -1.19593 -2.6164 -1.08043 1 1 0.992731 1 0.9927 zgc:123068 zgc:123068------Dr.14960.1.S1 at 1.505416 1.99882 2.284262 1.81592 1 1 0.90536 1 0.9054 im:6893299 im:6893299------Dr.14966.1.A1 at -1.82056 -2.16947 -1.36722 -2.39963 1 0.946941 1 0.942804 0.9428 ------Dr.14968.1.A1 at -1.36053 -2.37381 -2.64316 -2.11992 1 0.796 0.512892 0.973 0.5129 wu:fc83c09 wu:fc83c09------Dr.14971.1.A1 at -2.11243 -2.46077 -2.38398 -2.4413 0.99934 0.711513 0.923432 0.461445 0.4614 ------Dr.14972.1.S1 at 4.892403 3.382975 1.872746 2.138699 0.119 0.602617 1 0.9997 0.119 ------Dr.14974.1.S1 at -2.08291 -2.50883 -1.49811 -2.83117 0.98838 0.659609 1 0.288 0.288 ------Dr.14978.1.S1 at -1.58968 -1.88993 -1.42452 -2.19948 1 1 1 0.973237 0.9732 ------Dr.14986.1.S1 at 1.355191 1.727473 1.747417 2.139019 1 1 1 0.86 0.86 zgc:73139 zgc:73139 ------Dr.14991.1.A1_at -1.14195 1.180179 1.484014 2.660738 1 1 1 0.263916 0.2639 iah1 isoamyl ace--- lipid metabolic process /// lipid catabolic process lipase activity /// hydrolase activity /// hydrolase activity, --- acting on ester bonds Dr.14994.1.A1_at 2.292411 2.538456 1.203332 -1.46884 0.689509 0.113368 1 1 0.1134 mapk14b mitogen-ac--- protein amino acid phosphorylation /// response to stress /// nucleotide binding /// protein kinase activity /// protein nucleus /// cytoplasm protein kinase cascade serine/threonine kinase activity /// MAP kinase activity /// ATP binding /// MP kinase activity /// kinase activity /// transferase activity Dr.14998.2.S1 at 2.150685 1.91227 1.384056 1.981249 0.994816 1 1 1 0.9948 zgc:101710 zgc:101710--- metabolic process catalytic activity --- Dr.15002.1.S1 a at 2.563914 4.161452 3.624999 2.709213 0.364629 0.059817 0.101656 0.224523 0.0598 eif1ax eukaryotic t--- translation /// translational initiation RNA binding /// translation initiation factor activity --- Dr.15002.1.S1 at 1.799955 2.072824 2.205026 1.758147 1 0.983712 0.64909 1 0.6491 eif1ax eukaryotic t--- translation /// translational initiation RNA binding /// translation initiation factor activity --- Dr.15018.1.S1 at 1.150871 2.204032 2.390288 1.994554 1 0.997562 0.844818 0.999 0.8448 timm8b translocase ------Dr.15028.1.S1 s at -1.91367 -2.09099 -1.56339 -2.05545 1 0.9997 1 0.999955 0.9997 zgc:174165 zgc:174165------sugar binding membrane Dr.15032.1.S1 at 1.481545 3.114815 3.026421 2.599346 1 0.397862 0.508569 0.638101 0.3979 ------Dr.15036.1.S1 at -3.08252 -3.10527 -4.83237 -3.9233 0.395694 0.476504 0.161278 0.370471 0.1613 ------Dr.15038.1.S1_at 1.406065 2.601119 3.344978 4.213523 1 0.310779 0.063838 0.041222 0.0412 psmb1 proteasome --- ubiquitin-dependent protein catabolic process threonine-type endopeptidase activity /// endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome inhibitor activity /// peptidase activity /// hydrolase activity core complex /// protein complex

Dr.15045.1.S1 at -1.10082 -1.07868 1.230798 2.288256 1 1 1 0.499417 0.4994 gins2 GINS comp--- DNA replication ATP binding nucleus Dr.15059.1.S1 at 2.736233 3.613803 4.0982 3.627598 0.862 0.400181 0.313173 0.400945 0.3132 zgc:56567 zgc:56567 ------integral to membrane Dr.15059.2.S1 at 2.374552 3.494184 4.051147 3.357729 0.976817 0.495662 0.369 0.569467 0.369 ------Dr.1506.1.S1_at 3.031097 3.649045 4.197835 2.98182 0.104381 0.183882 0.028364 0.09333 0.0284 nola2 nucleolar p--- rRNA processing /// rRNA pseudouridine synthesis /// RNA binding /// snoRNA binding /// rRNA pseudouridylation nucleus /// small nucleolar ribonucleoprotein ribosome biogenesis guide activity complex /// ribonucleoprotein complex

Dr.15061.1.S1 at 3.982908 4.462169 4.28736 3.795381 0.090754 0.057191 0.031589 0.004468 0.0045 ppan peter pan h------Dr.15077.1.A1 at -1.57348 -1.79948 -1.45831 -2.07742 1 1 1 0.996964 0.997 si:rp71-1g18.7 Si:rp71-1g1------Dr.15080.1.S1 at 1.526334 2.487661 2.942215 2.654311 1 0.257447 0.401 0.101584 0.1016 zgc:153192 zgc:153192------calcium ion binding --- Dr.15087.1.A1_at 1.474559 2.220997 1.488598 1.635081 1 0.978485 1 1 0.9785 prkcb1 protein kina--- protein amino acid phosphorylation /// zinc ion transport /// nucleotide binding /// protein kinase activity /// protein --- intracellular signaling cascade serine/threonine kinase activity /// ATP binding /// zinc ion binding /// kinase activity /// transferase activity /// diacylglycerol binding /// metal ion binding Dr.15089.1.S1 at 1.128417 -2.39813 -2.64455 -2.85888 1 0.985 0.930374 0.867 0.867 rem1 rad and gem--- small GTPase mediated signal transduction nucleotide binding /// GTP binding --- Dr.15104.1.A1 at 1.042242 1.502091 2.19955 2.807916 1 1 0.949321 0.394588 0.3946 wu:fj68g08 wu:fj68g08 ------Dr.1511.1.A1 at -1.61535 -1.89612 -1.46442 -2.22863 1 1 1 0.898232 0.8982 ------Dr.15116.1.S1 at -1.2652 -2.47601 -2.09472 -1.74218 1 0.885105 0.998 1 0.8851 dnl2l light --- microtubule-based process microtubule motor activity microtubule associated complex Dr.15123.1.A1 at 1.400024 1.582017 1.782311 2.12189 1 1 1 0.977272 0.9773 ndufs6 NADH deh--- ubiquinone biosynthetic process ------Dr.1514.1.A1_at 1.680185 1.813249 1.834698 2.339035 1 1 1 0.377873 0.3779 rad51 RAD51 hom--- DNA metabolic process /// DNA repair /// response to nucleotide binding /// DNA binding /// damaged DNA binding intracellular cadmium ion /// response to methylmercury /// protein binding /// ATP binding /// DNA-dependent ATPase activity /// nucleoside-triphosphatase activity /// sequence-specific DNA binding

Dr.15140.1.S1 at 2.526343 4.603041 4.334109 3.0617 0.378199 0.007643 0.030844 0.090397 0.0076 zgc:56175 zgc:56175 ------Dr.15149.1.A1_at 3.400784 1.09803 1.560027 2.02122 0.297821 1 1 1 0.2978 zgc:158623 zgc:158623--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.15153.1.A1_at 1.538275 1.934403 2.135671 2.154583 1 1 0.959 0.873279 0.8733 rad23b RAD23 hom--- nucleotide-excision repair /// protein modification process /// damaged DNA binding nucleus proteasomal ubiquitin-dependent protein catabolic process

Dr.1516.1.A1 at 2.231428 2.361185 2.072554 1.975006 0.953712 0.875526 0.9997 1 0.8755 wu:fb39h11 wu:fb39h11------Dr.15162.3.A1_a_at 1.033219 1.315983 1.451775 2.497465 1 1 1 0.544902 0.5449 pofut1 protein O-f ------transferase activity /// transferase activity, transferring --- glycosyl groups /// peptide-O-fucosyltransferase activity

Dr.15165.2.A1 at 1.945284 3.566155 3.285023 2.154563 1 0.096127 0.127775 0.908747 0.0961 si:ch211-196f5.1 si:ch211-19------binding --- Dr.15182.1.S1 at 1.869471 2.174793 2.025251 2.074836 1 0.972 1 1 0.972 zgc:56596 zgc:56596 --- protein modification process ------Dr.15192.1.A1_at 1.010867 -2.45375 -2.84205 -3.50996 1 0.55023 0.305211 0.076602 0.0766 LOC791965 hypothetica--- oxidation reduction monooxygenase activity /// iron ion binding /// electron carrier --- activity /// oxidoreductase activity /// heme binding /// metal ion binding Dr.15193.1.A1_at 1.233724 2.446058 5.463657 8.243654 1 0.120852 0.012395 0.009696 0.0097 zgc:162648 zgc:162648--- metabolic process N-acetyltransferase activity /// acyltransferase activity /// membrane /// integral to membrane transferase activity Dr.15195.1.A1 at 1.129844 -1.75891 -2.58576 -1.95231 1 1 0.954804 0.999955 0.9548 ------Dr.15199.1.A1 at 2.535309 2.691888 2.551957 2.468077 0.828395 0.589677 0.789317 0.817 0.5897 ------Dr.152.1.A1 at 4.292896 -1.0879 -1.72147 -1.94373 0.396733 1 1 1 0.3967 cmya1 cardiomyop--- actin cytoskeleton organization and biogenesis actin binding cell junction Dr.15207.1.A1 at -1.47554 -1.91666 -1.31657 -2.42175 1 1 1 0.574904 0.5749 sb:cb627 sb:cb627 ------RNA binding /// double-stranded RNA binding intracellular Dr.15222.1.A1 at -2.41084 -5.03947 -5.67178 -3.06535 0.980296 0.235861 0.201 0.69818 0.201 ------Dr.15226.1.A1 at -1.83024 -2.04141 -1.37974 -2.60068 1 0.991876 1 0.437447 0.4374 ------Dr.15234.1.A1 at -1.02508 1.671078 1.894643 2.774136 1 1 1 0.448313 0.4483 zgc:110116 zgc:110116------binding --- Dr.15236.1.A1 at -1.25215 -2.0257 -2.48253 -1.72506 1 0.999 0.671592 1 0.6716 ------Dr.15254.1.A1_at -1.86899 -1.92173 -2.12731 -1.99895 1 1 0.96723 0.9997 0.9672 si:ch211-139a5.3 si:ch211-13--- lipid metabolic process hydrolase activity /// hydrolase activity, acting on ester bonds ---

Dr.15260.1.S1_at -2.3433 -1.61934 -1.57242 -1.83559 0.996557 1 1 1 0.9966 nr1d2b nuclear rec--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// steroid binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.15260.2.A1_at -5.6354 -1.70878 -1.95448 -2.24148 0.180403 1 1 0.957423 0.1804 nr1d2b nuclear rec--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// steroid binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.15261.1.A1_at -1.87856 -1.56822 -2.15588 -1.89926 1 1 0.999 1 0.999 cpeb4 cytoplasmic ------nucleotide binding /// nucleic acid binding /// RNA binding ---

Dr.15261.2.A1_at -2.09512 -2.41701 -2.3384 -2.28304 0.963 0.380194 0.834 0.824531 0.3802 cpeb4 cytoplasmic ------nucleotide binding /// nucleic acid binding /// RNA binding ---

Dr.15268.1.A1_at -1.28143 -2.26509 -2.88371 -2.48759 1 0.912807 0.241086 0.649661 0.2411 nfia nuclear fac--- DNA replication /// transcription /// transcription termination DNA binding /// transcription factor activity intracellular /// nucleus /// regulation of transcription, DNA-dependent /// transcription antitermination Dr.15269.1.S1 at -1.44922 -2.39755 -2.27131 -2.37346 1 0.779 0.884522 0.315599 0.3156 zgc:56033 zgc:56033 ------Dr.15272.1.A1 at -2.12173 -2.14284 -1.48832 -2.6758 0.991 0.798353 1 0.226446 0.2264 ------Dr.15297.1.A1 at -1.27227 -1.37442 -1.62343 -2.00148 1 1 1 0.996927 0.9969 ------Dr.15324.1.A1 at -1.11573 -1.68819 -2.41294 -2.34785 1 1 0.491227 0.354354 0.3544 ------Dr.15337.1.S1 at 1.355984 2.700214 1.626173 1.306841 1 0.452988 1 1 0.453 ------Dr.15347.1.S1 at 1.134903 -1.71305 -2.07345 -1.94533 1 1 0.968271 0.999955 0.9683 LOC562530 similar to M------Dr.15370.1.S1 at 1.089952 1.76049 1.962973 2.166451 1 1 1 0.87538 0.8754 si:dkey-13i19.8 si:dkey-13i ------Dr.15372.2.S1 at 1.131381 2.33388 2.986427 4.607162 1 0.819 0.144795 0.054081 0.0541 rps19 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.15379.1.A1 at 1.513105 1.534187 1.207034 2.574403 1 1 1 0.365315 0.3653 ------Dr.15382.1.A1 at 2.501291 2.097877 2.014412 2.063822 0.855 0.988927 1 0.99934 0.855 wu:fc14a08 wu:fc14a08------Dr.15385.1.S1_at 1.093141 2.015037 2.339988 3.249488 1 1 0.534 0.036696 0.0367 zgc:110330 zgc:110330--- ubiquitin-dependent protein catabolic process threonine-type endopeptidase activity /// endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome inhibitor activity /// peptidase activity /// hydrolase activity core complex /// protein complex

Dr.15393.1.A1 at -1.57421 -1.73178 -2.1012 -1.91908 1 1 0.987421 1 0.9874 zgc:110130 zgc:110130------membrane /// integral to membrane Dr.15402.1.A1_a_at 1.992581 2.073114 2.141918 2.550485 0.999955 1 0.999955 0.643 0.643 zgc:153680 zgc:153680--- translation RNA binding /// structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.15413.1.A1 at -5.08264 -4.89004 -5.042 -3.78911 0.017291 0.02591 0.019556 0.047534 0.0173 ------Dr.15424.1.S2 at 1.105344 1.287336 2.096372 1.987153 1 1 0.9997 1 0.9997 arpc5a actin relate--- regulation of actin filament polymerization --- cytoskeleton Dr.1543.1.S1 at 2.731742 4.158367 2.561856 1.772484 0.518208 0.092423 0.552881 1 0.0924 dnajc3 DnaJ (Hsp------binding /// heat shock protein binding --- Dr.15443.2.S1_at 1.261013 2.046624 2.425885 3.070416 1 0.998 0.29 0.05553 0.0555 rpl10a ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.15465.1.S1 at -1.49848 -1.64444 -1.79774 -2.09294 1 1 1 0.992263 0.9923 zgc:112148 zgc:112148------integral to membrane Dr.15466.1.S1 at -1.47894 -1.5746 -1.05595 -2.20943 1 1 1 0.978485 0.9785 ------Dr.1547.1.A1 at 2.507684 3.651078 2.705214 2.438933 0.701 0.089189 0.611 0.781714 0.0892 ------Dr.15472.1.S1_at -1.33317 -1.14913 -1.17499 7.918487 1 1 1 0.017724 0.0177 ttk ttk protein k--- protein amino acid phosphorylation /// cell cycle /// male nucleotide binding /// magnesium ion binding /// protein --- meiosis chromosome segregation /// mitotic cell cycle kinase activity /// protein serine/threonine kinase activity /// checkpoint /// embryonic development /// female meiosis protein tyrosine kinase activity /// ATP binding /// kinase chromosome segregation /// fin regeneration /// tissue activity /// transferase activity /// metal ion binding regeneration /// cell division Dr.15486.1.S1 x at -1.4021 -1.3397 -1.28144 2.425834 1 1 1 0.398878 0.3989 zgc:153369 zgc:153369------nucleus Dr.1551.1.A1 at 1.945806 2.367665 1.981836 2.460779 1 0.923697 1 0.894192 0.8942 dpp3 dipeptidylpe--- proteolysis --- cytoplasm Dr.15532.1.A1 at -1.49253 -1.57126 -1.18566 -2.0286 1 1 1 0.999917 0.9999 LOC100148646 similar to n------Dr.15539.1.A1_at -1.21512 1.190409 1.101152 3.184215 1 1 1 0.060401 0.0604 zgc:111879 zgc:111879--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity nucleus /// transcription factor complex transcription, DNA-dependent /// transcription antitermination Dr.15545.1.A1 at 2.027693 3.04643 3.090793 2.303909 0.990835 0.095424 0.164 0.215938 0.0954 tomm40l translocase --- anion transport voltage-gated anion channel activity mitochondrial outer membrane Dr.15550.1.A1_at -1.08908 -1.1051 1.432905 3.373915 1 1 1 0.267511 0.2675 zgc:113153 zgc:113153------nucleotide binding /// ATP binding /// nucleoside- --- triphosphatase activity Dr.15567.1.A1 at 2.563271 3.27907 2.639766 3.077753 0.237568 0.051474 0.162114 0.054 0.0515 wu:fk48d07 wu:fk48d07------Dr.1557.1.S1_at -1.33708 -1.24897 -1.0821 2.784756 1 1 1 0.496 0.496 kif11 kinesin fam--- microtubule-based movement nucleotide binding /// motor activity /// microtubule motor microtubule /// microtubule associated activity /// ATP binding complex Dr.15572.1.S1 at 2.301567 4.477951 5.191367 5.894197 0.991278 0.382434 0.329972 0.231675 0.2317 ------Dr.15587.1.S1 at 1.073395 1.573799 1.774112 2.231759 1 1 1 0.722428 0.7224 LOC562879 hypothetica------Dr.15589.1.S1_at 1.388873 2.696598 2.406343 2.414956 1 0.408637 0.878656 0.563721 0.4086 zgc:92628 zgc:92628 --- protein targeting /// transport /// intracellular protein transport --- mitochondrion /// mitochondrial outer /// protein transport membrane /// mitochondrial outer membrane translocase complex /// membrane /// integral to membrane /// outer membrane

Dr.15589.2.A1_at 1.548918 2.667997 2.554298 2.361405 1 0.105 0.173792 0.16356 0.105 zgc:92628 zgc:92628 --- protein targeting /// transport /// intracellular protein transport --- mitochondrion /// mitochondrial outer /// protein transport membrane /// mitochondrial outer membrane translocase complex /// membrane /// integral to membrane /// outer membrane Dr.15595.1.S1 at 1.467547 1.908168 2.232935 4.172679 1 1 0.834916 0.051278 0.0513 LOC100003436 similar to S ------Dr.15607.1.S1 at 1.684556 2.342493 2.28071 1.880567 1 0.984689 0.951403 1 0.9514 wu:fd15h01 wu:fd15h01------Dr.15635.1.A1 at 1.057071 1.009562 -1.01279 6.35238 1 1 1 0.077701 0.0777 DKEY-57A22.11 similar to C ------Dr.15652.1.S1_at -2.5423 -1.96048 -2.19479 -2.1601 0.986 1 0.9997 0.9997 0.986 pp2cb protein pho--- protein amino acid dephosphorylation magnesium ion binding /// catalytic activity /// protein serine/threonine phosphatase complex phosphoprotein phosphatase activity /// protein serine/threonine phosphatase activity /// manganese ion binding Dr.15653.1.S1 at -1.01462 1.009435 1.237502 4.137194 1 1 1 0.147959 0.148 im:7151414 im:7151414------Dr.15659.1.S1 at 2.359755 2.772953 2.936752 3.483939 0.997143 0.882437 0.836863 0.569467 0.5695 zgc:66388 zgc:66388 --- protein modification process --- cytoplasm Dr.1566.1.S1_at -1.97245 -2.93007 -2.61208 -2.10874 0.995 0.203611 0.381442 0.96775 0.2036 adh5 alcohol deh --- zinc ion transport /// metabolic process /// oxidation catalytic activity /// binding /// zinc ion binding /// --- reduction oxidoreductase activity /// metal ion binding Dr.15663.1.S1_at 2.389169 2.029101 1.715923 1.717622 0.832 1 1 1 0.832 cebpg CCAAT/en--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.15669.1.S1 at -2.45659 -2.41337 -2.66885 -2.73179 0.997562 0.972 0.742942 0.751 0.7429 boc brother of C--- axon guidance protein binding /// identical protein binding --- Dr.15687.2.S1 a at -2.07294 -2.6184 -2.34792 -1.80696 0.998 0.187 0.395333 1 0.187 zgc:92356 zgc:92356 --- metabolic process catalytic activity /// binding /// oxidoreductase activity --- Dr.15687.3.S1 at -2.15865 -2.60141 -2.59513 -1.70904 0.9997 0.470369 0.627149 1 0.4704 zgc:92356 zgc:92356 --- metabolic process catalytic activity /// binding /// oxidoreductase activity --- Dr.15724.1.S1 at -2.16702 -2.39105 -2.05141 -2.66931 0.89 0.787 0.982 0.479177 0.4792 dacha dachshund --- inner ear development nucleotide binding nucleus Dr.15726.1.S1_at -1.57358 -1.4823 -1.06703 3.596946 1 1 1 0.569 0.569 zgc:56708 zgc:56708 --- cell cycle /// mitosis /// cell division --- chromosome, centromeric region /// condensed chromosome kinetochore /// nucleus Dr.15728.1.A1 at -1.60242 -1.96589 -1.48798 -2.31354 1 1 1 0.864 0.864 ------Dr.15729.1.S1 at 1.935914 2.16192 1.819915 1.536391 1 0.999 1 1 0.999 dnaja3a DnaJ (Hsp--- protein folding heat shock protein binding /// unfolded protein binding --- Dr.15735.1.A1 at -1.82454 -2.40959 -1.63403 -2.58358 1 0.83 1 0.697892 0.6979 ------Dr.15736.1.S1 at -2.48616 -2.78055 -3.94761 -3.57484 0.915 0.455617 0.128428 0.25574 0.1284 LOC795627 similar to rC------Dr.15737.1.S1 at 1.380948 2.188767 2.235572 2.422097 1 0.406443 0.766 0.168206 0.1682 zgc:56576 zgc:56576 ------Dr.15742.1.A1 at 1.135877 1.550102 1.747253 2.330804 1 1 1 0.752456 0.7525 LOC568235 similar to M------Dr.15749.1.A1 at 1.946871 2.867771 2.363951 2.093949 0.999955 0.400387 0.972 0.999917 0.4004 tmem110 Transmem------integral to membrane Dr.15750.1.S1 at -1.00233 1.369694 1.876483 3.494107 1 1 1 0.019536 0.0195 zgc:92648 zgc:92648 --- protein folding heat shock protein binding /// unfolded protein binding --- Dr.15752.1.S1_at 1.153006 2.663998 1.69711 2.251635 1 0.796546 1 0.926319 0.7965 si:dkey-265m8.2 /// zgc:16si:dkey-265--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.15752.2.A1_at 1.475618 3.187047 2.026684 2.797998 1 0.236232 0.996552 0.459299 0.2362 si:dkey-265m8.2 /// zgc:16si:dkey-265--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.15759.1.A1_a_at 1.271662 2.014256 1.97779 3.676291 1 1 1 0.055033 0.055 zgc:92784 zgc:92784 --- regulation of transcription DNA binding /// RNA polymerase II transcription factor nucleus activity Dr.15759.1.A1_at 1.209935 1.390524 1.475596 2.205876 1 1 1 0.602863 0.6029 zgc:92784 zgc:92784 --- regulation of transcription DNA binding /// RNA polymerase II transcription factor nucleus activity Dr.15767.1.A1 at 1.878166 3.534541 3.591096 3.453087 1 0.289416 0.129417 0.367212 0.1294 zgc:110460 zgc:110460--- translation /// regulation of translation translation initiation factor activity --- Dr.15771.1.S1 at 2.787638 4.454202 3.915654 3.46018 0.288585 0.03456 0.040595 0.086276 0.0346 zgc:162306 zgc:162306--- metabolic process methyltransferase activity --- Dr.15779.2.A1 at -1.27125 -1.3188 -1.00893 3.015971 1 1 1 0.147656 0.1477 zgc:92661 zgc:92661 ------Dr.15783.1.S1 at -1.05846 -2.35413 -2.86558 -2.53169 1 0.948324 0.317 0.549409 0.317 zgc:92630 zgc:92630 --- metabolic process catalytic activity /// binding /// oxidoreductase activity --- Dr.15786.1.S1 at 1.858852 1.67697 1.525694 2.324521 1 1 1 0.960456 0.9605 LOC793515 similar to M------Dr.15788.1.S1 at 1.713066 2.493523 2.09098 2.185762 1 0.775735 0.999955 0.979693 0.7757 ------Dr.15796.1.S1 at 1.278998 11.53251 9.412351 4.385833 1 0.023199 0.008894 0.230693 0.0089 col15a1 collagen XV--- phosphate transport /// cell adhesion structural molecule activity /// binding cytoplasm /// extracellular matrix Dr.15802.2.S1 a at -2.9708 -5.56924 -4.93864 -6.07107 0.416417 0.025096 0.031 0.020082 0.0201 cryba4 crystallin, b------Dr.15814.1.S1_at 2.447927 3.216112 3.270138 2.242287 0.555976 0.132247 0.139152 0.947794 0.1322 si:dkeyp-70f9.5 si:dkeyp-70------mitochondrion /// ribosome /// ribonucleoprotein complex Dr.15828.1.A1 at -2.98099 -3.19942 -2.24136 -3.39349 0.204788 0.209438 0.998 0.121927 0.1219 si:dkey-78l4.14 Si:dkey-78l ------Dr.15855.1.A1_at -1.23486 -1.12206 -1.08803 4.399872 1 1 1 0.033218 0.0332 zgc:110417 zgc:110417--- cell cycle /// mitosis /// cell division --- condensed chromosome kinetochore /// nucleus Dr.15856.1.A1 at 7.96239 8.469169 9.166711 9.743621 0.039209 0.04659 0.037306 0.034513 0.0345 ------Dr.15857.1.A1_at 4.284377 6.684494 5.015093 6.291203 0.136955 0.045856 0.074 0.036692 0.0367 csrp1 cysteine an--- heart morphogenesis /// zinc ion transport /// JNK cascade protein binding /// zinc ion binding /// metal ion binding --- /// Wnt receptor signaling pathway /// cell migration involved in gastrulation /// convergent extension involved in gastrulation Dr.15857.2.S1_at 2.690775 3.96209 3.34257 3.916706 0.756 0.123652 0.408 0.123782 0.1237 csrp1 cysteine an--- heart morphogenesis /// zinc ion transport /// JNK cascade protein binding /// zinc ion binding /// metal ion binding --- /// Wnt receptor signaling pathway /// cell migration involved in gastrulation /// convergent extension involved in gastrulation Dr.15858.1.A1 at 1.512658 1.838884 1.682358 2.44297 1 1 1 0.496456 0.4965 ------Dr.15867.1.S1_at 1.729414 3.020925 3.502562 4.230093 1 0.334439 0.118815 0.011294 0.0113 rpl34 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.15869.1.A1 at 1.992497 2.225708 2.289235 2.051443 1 0.823937 0.95431 1 0.8239 ------Dr.15875.1.S1_at 1.577076 1.869456 1.579203 2.344957 1 1 1 0.993564 0.9936 ------NADH dehydrogenase activity /// NADH dehydrogenase mitochondrion (ubiquinone) activity Dr.15879.1.S1 at 1.686207 2.43196 2.468502 2.871372 1 0.759346 0.756 0.240854 0.2409 zgc:112322 zgc:112322--- translation structural constituent of ribosome intracellular /// ribosome Dr.15890.1.A1 at 1.598701 2.13389 2.055429 2.599584 1 0.955943 1 0.325704 0.3257 zgc:85812 zgc:85812 ------Dr.15913.1.S1 at -1.28247 -1.93083 -1.39394 -2.42344 1 1 1 0.550635 0.5506 ------Dr.15915.1.S1 at 1.698453 2.623032 2.658219 2.468133 1 0.544656 0.446453 0.634145 0.4465 LOC555692 similar to G ------nucleic acid binding intracellular Dr.15932.1.A1 at -1.10964 -1.03707 1.050733 2.209498 1 1 1 0.9456 0.9456 si:rp71-1f1.7 si:rp71-1f1 --- signal transduction cAMP-dependent protein kinase regulator activity --- Dr.15953.1.A1 at 2.632133 4.553161 3.126455 2.687341 0.956 0.453507 0.837872 0.980511 0.4535 ------Dr.15958.1.S1 at -1.99118 -2.26152 -1.51541 -2.67765 0.999955 0.847274 1 0.415866 0.4159 ------Dr.15969.1.A1 at -2.80212 -3.62883 -3.08259 -3.12864 0.737 0.319841 0.695833 0.585 0.3198 zgc:153612 zgc:153612------ATP binding --- Dr.15988.1.S1_at 1.587793 2.030168 1.508696 -1.21714 1 0.991918 1 1 0.9919 zgc:158852 zgc:158852------endopeptidase inhibitor activity /// serine-type endopeptidase --- inhibitor activity Dr.15991.1.S1 at 1.905773 3.087295 2.480394 2.289258 0.99934 0.201 0.825414 0.869132 0.201 LOC100000332 similar to ri------Dr.15996.1.S1 at 4.020645 5.93769 5.304721 5.794604 0.179977 0.053325 0.070313 0.043 0.043 LOC559409 similar to c------Dr.15997.1.S1 at -1.27374 -1.66707 -2.13793 -1.97646 1 1 0.83 0.9997 0.83 boc Brother of C--- axon guidance protein binding /// identical protein binding --- Dr.15999.1.A1_at 2.063649 2.170277 1.353448 1.456105 0.996674 0.996511 1 1 0.9965 zgc:101015 zgc:101015--- transport /// small GTPase mediated signal transduction /// nucleotide binding /// GTP binding plasma membrane /// membrane protein transport Dr.16000.1.S1 at 1.26328 -1.72212 -2.39152 -2.32583 1 1 0.803948 0.843718 0.8039 ------Dr.16002.1.A1 at 1.784891 2.356506 1.870251 1.78036 1 0.969444 1 1 0.9694 baz1a bromodoma------Dr.16009.1.A1 at 2.008694 3.338442 3.272554 4.426147 1 0.658727 0.845 0.387 0.387 zgc:101084 zgc:101084------Dr.16014.1.S1 at -1.18509 -1.52254 -2.70475 -1.76743 1 1 0.359 1 0.359 zgc:101897 zgc:101897--- metabolic process glutathione transferase activity cytoplasm Dr.16017.1.S1_at 1.888717 3.252534 3.202549 3.222198 1 0.026961 0.117114 0.103196 0.027 mrpl17 mitochondr--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.16020.1.A1 at -1.4087 -2.49546 -2.11567 -2.96279 1 0.949291 0.999955 0.166914 0.1669 ------Dr.16025.1.S1_at 1.536634 2.920658 3.398707 3.416349 1 0.013345 0.012083 0.035075 0.0121 zgc:56682 zgc:56682 --- mRNA processing /// RNA splicing /// mRNA metabolic RNA binding nucleus /// ribonucleoprotein complex process Dr.1603.1.A1_at -1.0479 -1.97656 -2.42056 -5.21227 1 1 0.894192 0.124331 0.1243 cyp51 Cytochrom--- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// --- iron ion homeostasis methyltransferase activity /// electron carrier activity /// heme binding /// metal ion binding Dr.1603.1.A1_x_at -1.02229 -2.05581 -2.58683 -4.92947 1 0.999955 0.630311 0.061833 0.0618 cyp51 Cytochrom--- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// --- iron ion homeostasis methyltransferase activity /// electron carrier activity /// heme binding /// metal ion binding Dr.16031.1.S1 at 1.294884 2.257411 1.9331 2.1303 1 0.996244 1 0.9997 0.9962 DKEY-58F10.1 novel prote--- translation structural constituent of ribosome intracellular /// ribosome Dr.16034.1.S1 at -1.06049 1.343914 1.581386 4.647276 1 1 1 0.027225 0.0272 zgc:86839 zgc:86839 --- cell cycle cyclin-dependent protein kinase regulator activity --- Dr.16034.2.A1 at 1.248289 1.809804 3.028172 8.471408 1 1 0.185372 0.011091 0.0111 zgc:86839 zgc:86839 --- cell cycle cyclin-dependent protein kinase regulator activity --- Dr.16044.1.S1 at 1.821421 2.901803 2.23474 1.978061 1 0.206064 0.99556 1 0.2061 zgc:77041 zgc:77041 ------membrane /// integral to membrane Dr.16048.1.S1_at 4.060466 8.056437 5.15637 2.374034 0.321264 0.017447 0.119168 0.933631 0.0174 mycb myelocytom--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// transcription nucleus transcription, DNA-dependent /// transcription regulator activity antitermination /// regulation of transcription Dr.16053.1.S1 at 3.68516 7.309213 8.30547 4.535468 0.270166 0.042064 0.084617 0.119492 0.0421 zgc:175091 zgc:175091------Dr.16078.1.S1 at 1.075595 1.031055 -1.1157 4.411847 1 1 1 0.176403 0.1764 dcn decorin ------protein binding --- Dr.16088.1.A1_at 1.573031 3.097115 1.515107 1.49078 1 0.212612 1 1 0.2126 kctd12.2 potassium --- potassium ion transport ion channel activity /// voltage-gated potassium channel voltage-gated potassium channel complex /// activity /// protein binding membrane Dr.16088.2.S1_at 1.082256 2.241353 1.109258 1.037326 1 0.922 1 1 0.922 kctd12.2 potassium --- potassium ion transport ion channel activity /// voltage-gated potassium channel voltage-gated potassium channel complex /// activity /// protein binding membrane Dr.161.1.S1_at 1.739601 2.869368 3.005799 3.477614 1 0.308634 0.175373 0.098903 0.0989 eif3g eukaryotic t------nucleotide binding /// nucleic acid binding /// translation --- initiation factor activity Dr.16108.1.S1 at 2.242433 3.553349 3.713648 3.383646 0.806691 0.10117 0.088554 0.147055 0.0886 nip7 nuclear imp--- ribosome assembly RNA binding /// protein binding nucleus Dr.16118.1.A1 at -1.67147 -2.14785 -1.76502 -2.10081 1 0.929438 1 0.986338 0.9294 LOC567833 similar to M------Dr.16123.1.S1 at 2.713584 2.751719 2.610205 1.942936 0.478932 0.502661 0.347272 1 0.3473 zgc:56486 zgc:56486 ------Dr.16124.1.S1 at 2.112175 2.438152 2.433744 2.136318 0.992952 0.746657 0.455032 0.994659 0.455 gnl2 /// LOC796095 guanine nu------GTP binding intracellular Dr.16130.1.S1_at -1.78072 -2.22231 -1.96986 -1.52858 1 0.713719 1 1 0.7137 adh8b alcohol deh --- cellular alcohol metabolic process /// ethanol metabolic catalytic activity /// alcohol dehydrogenase activity /// binding --- process /// octanol metabolic process /// zinc ion transport /// zinc ion binding /// oxidoreductase activity /// /// metabolic process /// formaldehyde metabolic process /// formaldehyde dehydrogenase activity /// metal ion binding oxidation reduction

Dr.16133.1.A1 a at 2.687289 3.581678 2.271425 1.763039 0.808368 0.152 0.832686 1 0.152 ------Dr.1618.1.S1 at -1.35562 -1.65629 -2.04801 -1.53528 1 1 0.9997 1 0.9997 kiaa0907 KIAA0907 ------Dr.16183.1.S1_at -1.24489 -1.0918 -1.00558 2.333286 1 1 1 0.400824 0.4008 dlc deltaC --- somitogenesis /// somitogenesis /// somitogenesis /// calcium channel activity /// calcium ion binding /// calcium signal recognition particle, endoplasmic calcium ion transport /// cell communication /// Notch channel inhibitor activity /// PDZ domain binding /// PDZ reticulum targeting /// plasma membrane /// signaling pathway /// multicellular organismal development domain binding /// identical protein binding membrane /// integral to membrane /// /// negative regulation of signal transduction /// cell perinuclear region of cytoplasm differentiation /// neuron development

Dr.16191.1.A1 at 1.948204 3.829847 3.853861 3.254069 1 0.035493 0.071264 0.085159 0.0355 adam9 a disintegri--- proteolysis /// integrin-mediated signaling pathway metalloendopeptidase activity /// zinc ion binding --- Dr.16193.1.S1_at -4.80065 -5.17716 -6.45992 -4.36082 0.2 0.247668 0.08691 0.16456 0.0869 si:rp71-57j15.4 si:rp71-57j --- signal transduction /// phosphorylation /// peptidyl-histidine two-component sensor activity /// protein histidine kinase --- phosphorylation activity /// ATP binding /// kinase activity /// transferase activity, transferring phosphorus-containing groups

Dr.16195.1.A1 at -3.48338 -2.71439 -2.49604 -1.76602 0.611136 0.891922 0.867 1 0.6111 ------Dr.16197.1.A1 at -1.34215 -1.53892 -1.56146 -2.03476 1 1 1 0.987827 0.9878 ------Dr.16200.1.A1 at -1.13154 1.047689 1.00511 2.270594 1 1 1 0.810228 0.8102 ------Dr.16203.1.A1_at 1.346184 1.893307 1.838998 2.410034 1 1 1 0.636 0.636 zgc:158130 zgc:158130--- protein amino acid N-linked glycosylation /// protein alpha-1,3-mannosylglycoprotein 2-beta-N- Golgi membrane /// membrane secretion acetylglucosaminyltransferase activity /// protein transporter activity Dr.16239.1.A1 at -3.12332 -6.11264 -6.20455 -3.13519 0.6497 0.207904 0.168564 0.765353 0.1686 ------Dr.16255.1.A1 at 1.561756 2.171239 2.16858 1.898432 1 0.862 0.987681 1 0.862 ------Dr.16283.1.A1 at -1.56579 -2.26308 -2.76926 -2.92068 1 0.182149 0.05324 0.027684 0.0277 ------Dr.16284.1.S1_at 1.75111 3.216148 3.392249 2.56337 1 0.074355 0.038282 0.113813 0.0383 pabpc4 poly(A) bind------nucleotide binding /// nucleic acid binding /// RNA binding ---

Dr.16287.1.A1 at -1.35467 -2.37173 -2.50997 -2.14786 1 0.861246 0.834 0.977272 0.834 zgc:162186 zgc:162186------Dr.16294.1.A1 at -2.55052 -2.17154 -2.77527 -2.35261 0.986 0.99934 0.952 0.999 0.952 ------Dr.16296.1.S1 a at 1.24912 -1.7136 -1.62245 -2.14952 1 1 1 0.975425 0.9754 LOC565189 hypothetica------nucleic acid binding /// zinc ion binding intracellular Dr.16296.1.S1 at -1.02667 -1.86602 -1.55732 -2.28603 1 1 1 0.779555 0.7796 LOC565189 /// zgc:17471 hypothetica------nucleic acid binding /// zinc ion binding intracellular Dr.16296.1.S1 x at 1.085981 -1.65234 -1.61745 -2.21243 1 1 1 0.878 0.878 LOC565189 hypothetica------nucleic acid binding /// zinc ion binding intracellular Dr.16296.2.A1 x at 1.114745 -1.66293 -1.46192 -2.12129 1 1 1 0.76518 0.7652 ------Dr.16298.1.A1_at -2.86244 -2.65918 -2.92163 -2.1932 0.684476 0.671804 0.420754 0.983325 0.4208 ulk1 unc-51-like --- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.16311.1.A1 at 2.709653 3.759166 1.922762 1.451441 0.88561 0.668 1 1 0.668 ------Dr.16314.1.S1_at 1.892305 3.061682 2.929406 2.870998 1 0.438334 0.459154 0.423095 0.4231 rrp1 /// wu:fi05d01 ribosomal R--- rRNA processing --- nucleolar preribosome, small subunit precursor Dr.16318.1.A1 at -1.48604 -1.59595 -1.37158 -2.09288 1 1 1 0.996244 0.9962 ------Dr.16319.1.A1 at 3.140187 -2.142 -1.73817 -1.47897 0.81045 0.998 1 1 0.8105 ------Dr.1632.1.A1 at 1.071885 1.370468 1.227756 9.585967 1 1 1 0.03147 0.0315 LOC795944 similar to p ------Dr.16321.1.S1_at 1.697809 2.286258 2.353171 1.955661 1 0.931552 0.954634 1 0.9316 LOC100148268 /// med10 similar to M--- transcription /// transcription termination /// regulation of --- nucleus transcription, DNA-dependent /// multicellular organismal development /// heart development /// Wnt receptor signaling pathway /// transcription antitermination

Dr.16321.2.S1_a_at 1.058101 2.047612 2.231405 1.773486 1 0.999 0.997143 1 0.9971 LOC100148268 /// med10 similar to M--- transcription /// transcription termination /// regulation of --- nucleus transcription, DNA-dependent /// multicellular organismal development /// heart development /// Wnt receptor signaling pathway /// transcription antitermination

Dr.16322.1.A1 at -1.57536 -2.51791 -2.12152 -1.63996 1 0.95366 0.9997 1 0.9537 add1 adducin 1 ( ------metal ion binding --- Dr.16351.1.A1 at -2.16121 -2.3502 -2.06289 -2.00953 1 0.978746 1 1 0.9787 LOC571741 similar to S ------Dr.1636.1.A1 at 2.04194 2.846551 2.671192 2.758941 0.984476 0.141 0.361501 0.210444 0.141 ifrd2 interferon-r------binding --- Dr.16360.1.A1 at -2.08769 -2.82972 -2.64827 -2.63196 1 0.418385 0.599 0.5852 0.4184 LOC558079 similar to d------Dr.16370.1.S1 at -2.81148 -3.5242 -3.32483 -3.31454 0.751 0.25538 0.342314 0.327 0.2554 mobkl2a MOB1, Mp------protein binding /// kinase activity --- Dr.16376.1.A1 at -2.02631 -2.25631 -1.72775 -2.54297 0.996511 0.916 1 0.68158 0.6816 ------Dr.16377.1.A1 at -1.59415 -2.5245 -2.4184 -1.80542 1 0.719 0.765353 1 0.719 ------Dr.16379.1.A1 at -1.53782 -8.48259 -19.6359 -16.1267 1 0.024457 0.004594 0.010492 0.0046 si:dkey-63j12.1 si:dkey-63j --- vesicle-mediated transport --- integral to membrane Dr.16385.1.A1 at -8.19461 1.516851 1.290865 1.426702 0.148171 1 1 1 0.1482 si:ch211-284a13.1 si:ch211-28------Dr.16386.1.A1 at 1.071571 -1.28994 1.144867 2.906438 1 1 1 0.407464 0.4075 im:7147988 im:7147988------Dr.16391.1.A1 at 2.369445 2.908827 2.596878 2.428961 0.876619 0.257923 0.385 0.599926 0.2579 acsl4 acyl-CoA s--- metabolic process catalytic activity --- Dr.16392.1.A1 at 20.72398 28.80421 11.83803 5.170978 0.044 0.023843 0.014687 0.185667 0.0147 c6 complemen------Dr.16395.1.A1 at 5.541945 9.616412 3.914489 2.321538 0.075274 0.009454 0.078552 0.879 0.0095 ------Dr.16405.1.S1 at -1.09687 -2.43101 -2.72056 -2.28165 1 0.68963 0.334302 0.684328 0.3343 zgc:56429 zgc:56429 --- proteolysis peptidase activity --- Dr.16410.1.A1_at -1.88856 -2.10339 -1.92891 -2.77487 1 0.984 1 0.349808 0.3498 agxtl alanine-glyo--- metabolic process catalytic activity /// transaminase activity /// transferase --- activity /// pyridoxal phosphate binding Dr.16411.1.A1 at -1.8825 -2.72885 -3.78142 -2.6878 1 0.427154 0.124668 0.515445 0.1247 ------Dr.16412.1.A1 at 1.300326 -4.17138 -7.26003 -5.7203 1 0.592468 0.095671 0.197751 0.0957 ------Dr.16422.1.S1_at -1.61565 -2.00407 -1.55047 -1.02299 1 0.99934 1 1 0.9993 diras1 DIRAS fam--- intracellular protein transport /// nucleocytoplasmic transport nucleotide binding /// GTPase activity /// protein binding /// intracellular /// signal transduction /// small GTPase mediated signal GTP binding transduction Dr.16425.1.A1 at -1.63616 -2.0761 -1.51415 -2.06215 1 0.972 1 0.984476 0.972 ------Dr.16427.1.A1 at 1.255153 -2.26988 -3.06243 -2.30594 1 0.586719 0.024136 0.457129 0.0241 ------Dr.16432.1.A1 at -2.22676 -2.88694 -3.00697 -2.78999 0.999955 0.734322 0.659075 0.827463 0.6591 gdf6a Growth/diff--- multicellular organismal development /// growth growth factor activity extracellular region Dr.16433.1.A1 at -2.10742 -1.81388 -2.10918 -2.66142 0.915495 1 0.98016 0.057715 0.0577 ------Dr.16450.1.A1 at 1.651286 2.336778 1.684088 -1.09302 1 0.743415 1 1 0.7434 LOC100006249 similar to c ------Dr.16470.1.A1 at -1.86023 -1.73025 -1.63669 -2.34978 1 1 1 0.993564 0.9936 ------Dr.16481.1.A1 at -1.49572 -3.00806 -3.63443 -2.95836 1 0.15044 0.079601 0.200879 0.0796 wu:fi38a10 wu:fi38a10 ------Dr.16489.1.A1_at 2.105171 2.400862 1.438811 1.834924 0.986 0.720723 1 1 0.7207 zgc:171912 zgc:171912--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.16500.1.A1 at -1.4659 -2.63049 -2.96267 -2.20426 1 0.469889 0.265835 0.983566 0.2658 ------Dr.16505.1.A1 at -1.33639 -1.82738 -2.35271 -1.68231 1 1 0.477 1 0.477 ------Dr.16510.1.A1 at -1.79705 -1.66129 -1.50602 -2.09495 1 1 1 0.998 0.998 ------Dr.16519.1.S1_at 2.280371 2.951713 2.994152 3.344813 0.955674 0.596196 0.635313 0.416987 0.417 metap2 methionyl a --- proteolysis /// cobalt ion transport /// Wnt receptor signaling aminopeptidase activity /// endopeptidase inhibitor activity /// cytoplasm pathway /// Wnt receptor signaling pathway /// protein peptidase activity /// metalloexopeptidase activity /// cobalt processing /// peptidyl-methionine modification /// N-terminal ion transmembrane transporter activity /// hydrolase activity protein amino acid modification /// metal ion binding /// cobalt ion binding

Dr.16542.1.A1 at 2.403456 4.508235 4.303951 2.430611 0.790793 0.188095 0.116835 0.836683 0.1168 grwd1 glutamate-r------Dr.16552.1.S1 at -1.41127 -1.43354 -1.74813 -2.36544 1 1 1 0.898232 0.8982 LOC558158 hypothetica--- protein folding heat shock protein binding /// unfolded protein binding --- Dr.16553.1.A1 at -1.1281 1.108307 1.174759 3.184636 1 1 1 0.136479 0.1365 zgc:92259 zgc:92259 ------Dr.16570.1.A1 at -1.57196 -2.26268 -2.05317 -1.52867 1 0.544204 0.99934 1 0.5442 si:ch211-105d4.5 si:ch211-10------Dr.16580.1.A1_at -1.44145 -2.14683 -3.154 -3.07825 1 0.989 0.584389 0.536372 0.5364 epas1 endothelial --- transcription /// transcription termination /// regulation of DNA binding /// signal transducer activity /// transcription nucleus transcription, DNA-dependent /// signal transduction /// regulator activity transcription antitermination /// regulation of transcription

Dr.1659.1.A1 at -2.42771 -3.3862 -5.11537 -4.05196 0.509541 0.051477 0.019271 0.049606 0.0193 wu:fc02a12 wu:fc02a12------Dr.16605.1.A1_at 2.596899 4.14325 3.797214 3.002855 0.502661 0.045663 0.023362 0.031347 0.0234 zgc:158760 zgc:158760--- translation structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex

Dr.16606.1.S1_at 1.065543 1.516497 1.581088 2.083471 1 1 1 0.991893 0.9919 zgc:56218 zgc:56218 --- negative regulation of signal transduction --- signal recognition particle, endoplasmic reticulum targeting /// membrane /// integral to membrane Dr.16613.1.S1 at 1.949408 2.040322 1.76087 1.754231 0.999917 0.9997 1 1 0.9997 stam signal trans--- intracellular protein transport ------Dr.16618.1.A1 at -1.78791 -1.83377 -1.43086 -2.17986 1 1 1 0.984476 0.9845 LOC556709 similar to A------Dr.16637.1.A1 x at -1.22749 -1.72876 1.073864 -2.12457 1 1 1 0.996557 0.9966 LOC560538 Hypothetica------Dr.16652.1.S1 at -2.20184 -2.46128 -2.66094 -2.70678 0.997562 0.919 0.735907 0.742072 0.7359 LOC100151631 similar to C------Dr.16652.2.A1 at -1.63765 -2.9939 -3.71349 -3.02832 1 0.08186 0.08243 0.048193 0.0482 LOC100151631 similar to C------Dr.16655.1.S1 at -1.63459 -2.0398 -1.5983 -1.63671 1 0.998 1 1 0.998 zgc:56518 zgc:56518 ------Dr.16660.1.A1 at 1.244226 1.945598 2.415273 2.050544 1 1 0.686 0.99934 0.686 ------Dr.16670.1.S1 at 1.612498 2.351454 1.944783 1.194726 1 0.718 1 1 0.718 zgc:100806 zgc:100806------exo-alpha-sialidase activity soluble fraction /// cytosol Dr.16675.1.A1_at 2.293969 3.31619 3.644536 3.052932 0.942 0.086924 0.07985 0.205445 0.0799 mrp63 mitochondr------mitochondrion /// ribosome /// ribonucleoprotein complex Dr.1668.1.S1_at 1.507711 3.330311 3.080361 2.160732 1 0.210598 0.411583 0.957 0.2106 hprt1 hypoxanthin--- purine ribonucleoside salvage /// nucleoside metabolic hypoxanthine phosphoribosyltransferase activity /// cytoplasm process transferase activity /// transferase activity, transferring glycosyl groups Dr.16680.1.S1 at -1.0817 -1.81674 -2.43912 -2.65005 1 1 0.846 0.747252 0.7473 ------Dr.16685.1.S1_at 1.324162 1.99414 2.27045 3.135247 1 1 0.941866 0.159913 0.1599 zgc:92656 zgc:92656 --- transcription /// transcription termination /// regulation of --- nucleus transcription, DNA-dependent /// transcription antitermination Dr.16685.2.A1 at 1.157944 1.518512 2.001335 2.58546 1 1 1 0.521623 0.5216 ------Dr.16707.1.A1_at -1.61667 -1.62238 -1.87785 -2.09198 1 1 1 0.998961 0.999 CH211-139A5.8 novel prote--- signal transduction /// small GTPase mediated signal nucleotide binding /// receptor activity /// GTP binding intracellular transduction Dr.1671.1.A1 at 2.146472 2.677661 2.024667 1.996644 1 0.5 0.99994 0.999955 0.5 si:ch211-119b12.6 si:ch211-11--- transport transporter activity integral to membrane Dr.16723.1.A1 at 1.334303 -1.7464 -2.46551 -2.0167 1 1 0.710576 0.995 0.7106 ------Dr.16731.1.A1 at -1.00105 -1.02582 2.146467 2.344909 1 1 0.99934 0.912807 0.9128 ------Dr.16737.1.S1 at 1.52733 -1.60206 -2.2589 -2.05039 1 1 0.976293 0.995 0.9763 ------Dr.16738.1.A1 at -1.49621 -1.93109 -1.65785 -2.09921 1 1 1 0.9997 0.9997 ------Dr.16741.1.A1 at -1.65877 -1.52395 -1.89204 -2.18134 1 1 1 0.972 0.972 ------Dr.16747.1.A1 at 2.044369 2.854768 2.263474 1.849962 0.989 0.302514 0.739729 1 0.3025 LOC100004261 similar to m------Dr.16752.1.A1 at 1.214963 1.74829 2.094053 2.296559 1 1 1 0.864 0.864 zgc:101576 zgc:101576------hydrolase activity /// metal ion binding --- Dr.16753.2.A1_at -2.10025 -4.10337 -4.29256 -2.90511 0.998 0.121495 0.110994 0.429676 0.111 dpysl3 dihydropyri ------hydrolase activity /// hydrolase activity, acting on carbon- --- nitrogen (but not peptide) bonds Dr.16757.1.A1 at 2.921104 2.445072 2.676662 1.680808 0.556 0.77822 0.92 1 0.556 ubxn4 UBX doma------Dr.16769.1.A1_at -1.77069 -2.16903 -2.29186 -1.92796 1 0.967491 0.907435 1 0.9074 cirbp /// LOC100002393 cold induci------nucleotide binding /// nucleic acid binding /// translation --- elongation factor activity Dr.16770.1.A1 at 5.012415 5.805744 4.171194 3.686389 0.082504 0.046235 0.103835 0.279868 0.0462 LOC100150452 /// LOC55similar to S------Dr.16781.1.S1 at -1.86159 -1.7719 -2.31572 -1.97295 1 1 0.695 0.999955 0.695 ------Dr.16787.1.A1 at -1.42094 -2.42066 -2.6898 -2.47819 1 0.654664 0.397 0.759 0.397 ------Dr.16789.1.A1 at -1.06668 -2.73552 -2.94848 -2.11573 1 0.06053 0.192537 0.938751 0.0605 ------Dr.16793.1.A1 at 5.026921 6.908696 6.586723 4.29911 0.05299 0.034714 0.058178 0.064 0.0347 brp16 brain protei------binding --- Dr.16794.2.A1 a at -2.08078 -2.27794 -3.06873 -3.27142 0.999955 0.745583 0.398906 0.168703 0.1687 ------Dr.1680.1.S1_at -1.31266 -2.18324 -1.83073 -2.0172 1 0.993617 1 1 0.9936 meis3 myeloid eco--- regulation of transcription, DNA-dependent /// pancreas DNA binding /// transcription factor activity /// sequence- nucleus development /// exocrine pancreas development /// specific DNA binding regulation of transcription Dr.16816.1.S1 at 2.406959 4.158868 4.455515 5.048281 0.587 0.105879 0.024485 0.034066 0.0245 si:dkey-34f16.5 si:dkey-34f --- protein amino acid dephosphorylation protein tyrosine phosphatase activity --- Dr.16862.1.A1 at -1.34013 -1.23265 1.268859 2.737998 1 1 1 0.616564 0.6166 LOC445411 RIKEN cDN------cysteine protease inhibitor activity --- Dr.16863.1.A1 at 2.658257 4.355665 3.75788 4.171617 0.231536 0.024632 0.024969 0.071137 0.0246 zgc:101877 zgc:101877------Dr.16874.1.S1_at 2.610407 3.943218 3.316349 2.628493 0.372159 0.042554 0.215593 0.26391 0.0426 zgc:66135 zgc:66135 --- biosynthetic process mannose-1-phosphate guanylyltransferase activity /// --- acyltransferase activity /// transferase activity /// nucleotidyltransferase activity Dr.16885.1.A1_at -1.81782 -2.17423 -1.48728 -1.44258 1 0.984725 1 1 0.9847 sptlc2 serine palm--- metabolic process /// biosynthetic process catalytic activity /// transferase activity /// transferase activity, --- transferring nitrogenous groups /// pyridoxal phosphate binding Dr.16892.1.A1 at -1.95512 -2.51333 -2.58057 -2.63376 0.999955 0.479 0.344036 0.309192 0.3092 mpp2b membrane ------protein binding --- Dr.169.1.S1 at 2.006865 2.559219 2.196597 2.018657 1 0.328098 0.998 0.999955 0.3281 aip /// LOC100149392 aryl hydroc--- protein folding receptor activity /// binding --- Dr.16907.1.S1 at -1.65028 -2.03401 -1.49148 -2.51844 1 1 1 0.459154 0.4592 ------Dr.1691.1.S1_at -2.57909 -1.92176 -1.05354 8.301399 0.260983 0.999955 1 0.02872 0.0287 rrm2 ribonucleot--- DNA replication /// iron ion transport /// cellular iron ion ribonucleoside-diphosphate reductase activity /// iron ion cytoplasm homeostasis /// deoxyribonucleoside diphosphate metabolic binding /// oxidoreductase activity /// metal ion binding /// process /// oxidation reduction transition metal ion binding Dr.1691.14.S1 at 1.164235 -2.06187 -2.18162 -1.95064 1 1 0.99934 0.99934 0.9993 sb:cb8 sb:cb8 ------Dr.1691.3.S1_at 2.755459 4.657423 5.202438 5.184924 0.475172 0.012605 0.026346 0.022118 0.0126 cct5 chaperonin --- protein folding /// cellular protein metabolic process nucleotide binding /// protein binding /// ATP binding /// cytoplasm unfolded protein binding Dr.1691.4.A1_at -1.45332 1.068663 1.46833 11.78574 1 1 1 0.011185 0.0112 kpna2 karyopherin --- protein import into nucleus /// intracellular protein transport binding /// protein transporter activity nucleus /// nuclear pore /// cytoplasm

Dr.1691.6.A1 at 1.962793 2.018803 2.157121 3.909471 0.998961 0.999955 0.99321 0.118432 0.1184 fam60al family with ------DNA binding --- Dr.1691.9.S1_at -1.90536 -1.94285 -1.4166 -2.5686 1 1 1 0.354 0.354 he1 /// LOC569018 /// LOChatching en--- proteolysis /// zinc ion transport endopeptidase inhibitor activity /// metalloendopeptidase --- inhibitor activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding Dr.1692.1.S1_at 1.963968 1.56004 1.393094 2.329138 0.999955 1 1 0.557525 0.5575 zbtb2b zinc finger --- zinc ion transport nucleic acid binding /// protein binding /// zinc ion binding /// intracellular /// nucleus metal ion binding Dr.16930.1.A1 at 4.876621 12.93752 15.4 17.12579 0.066659 0.018504 0.013133 0.011844 0.0118 ------Dr.16935.1.A1 x at -1.02295 -1.28185 -2.09866 -1.59965 1 1 0.99321 1 0.9932 LOC558832 Hypothetica------Dr.1695.1.A1 at 1.349234 1.965467 2.052419 1.677119 1 1 0.997 1 0.997 im:7150924 /// im:7151572im:7150924------binding --- Dr.16952.1.A1 at -1.52356 -1.60668 -1.37383 -2.16203 1 1 1 0.925 0.925 ------Dr.16953.1.A1 at -1.64045 -1.98849 -1.55502 -2.07284 1 1 1 0.987703 0.9877 ------Dr.16960.1.A1 at -1.82624 -1.90519 -1.51949 -2.15793 1 1 1 0.944529 0.9445 ------Dr.16968.1.A1 at -1.95162 -1.85932 -1.4823 -2.19625 0.999955 1 1 0.996927 0.9969 ------Dr.16969.1.S1 at -3.79472 -6.16329 -7.97337 -4.66658 0.15792 0.094227 0.02932 0.077245 0.0293 ------Dr.1698.1.A1 at -1.45973 -1.79028 -1.50559 -2.11585 1 1 1 0.979693 0.9797 wu:fc14e11 wu:fc14e11------Dr.16980.1.S1_at 1.504016 2.300978 2.438064 3.404973 1 0.917446 0.633704 0.071715 0.0717 zgc:112089 zgc:112089--- translation structural constituent of ribosome intracellular /// ribosome /// large ribosomal subunit Dr.16996.1.A1 at 2.712971 2.844853 2.403684 2.123436 0.315589 0.241202 0.682378 0.979287 0.2412 zgc:92917 zgc:92917 ------Dr.16998.1.A1 at 1.980738 2.671561 1.864242 1.310535 0.992263 0.178946 1 1 0.1789 LOC100150129 similar to in------Dr.17014.1.S1 at -1.01464 -1.85451 -2.2723 -2.18764 1 1 0.87033 0.887363 0.8703 LOC100008021 similar to P------Dr.1702.1.A1 at 1.652434 2.519106 2.187167 2.326632 1 0.821 0.979287 0.44164 0.4416 immt inner memb------Dr.17029.1.S1 at -1.33479 -2.42345 -1.99024 -2.11287 1 0.478 0.99994 0.940461 0.478 ------Dr.17041.1.A1 at -1.82173 -1.97855 -1.44868 -2.50102 1 1 1 0.445 0.445 ------Dr.17055.1.S1 at 2.016889 2.335741 2.541148 2.279245 1 0.607 0.301715 0.28237 0.2824 lsm8 LSM8 hom------Dr.17070.1.A1 at -5.53968 -2.00877 -2.68431 -1.85671 0.105879 1 0.791 1 0.1059 wu:fj84d10 wu:fj84d10 ------Dr.17081.1.S1 at 1.241337 2.048115 2.560847 2.107313 1 1 0.56 0.984 0.56 surf6l surfeit 6-lik ------Dr.17106.1.S1_at -2.05171 -1.85028 -1.47551 -2.15625 0.998 1 1 0.994582 0.9946 zgc:56231 zgc:56231 --- microtubule-based movement nucleotide binding /// motor activity /// microtubule motor microtubule /// microtubule associated activity /// ATP binding complex Dr.17108.1.S1 at 1.215304 1.508839 2.054147 2.677418 1 1 1 0.185 0.185 LOC100000862 similar to U------Dr.17111.1.A1 at 2.37072 2.316003 1.250909 1.097469 0.387792 0.645 1 1 0.3878 LOC100149211 similar to O------Dr.17114.1.A1 at -2.17121 -1.70252 -1.94647 -1.69285 0.9997 1 1 1 0.9997 ------Dr.17124.1.A1 at -1.11756 -1.82271 -1.98344 -2.00712 1 1 1 0.984725 0.9847 ------Dr.17136.1.A1 at -1.84625 -2.03888 -1.51908 -2.55222 1 1 1 0.507551 0.5076 ------Dr.17137.1.S1_at -1.23463 -1.69488 -2.29532 -2.31739 1 1 0.87835 0.924 0.8783 rorab RAR-relate--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.17139.1.A1 at -2.87418 -3.59631 -3.48583 -2.46333 0.404838 0.210215 0.344863 0.949321 0.2102 ------Dr.17141.1.A1 at -1.18923 -1.30587 -2.05509 -1.41957 1 1 0.993 1 0.993 ------Dr.17164.1.A1_at 1.154424 -1.97525 -1.70586 -2.00041 1 0.999955 1 0.99934 0.9993 tmem178 transmemb--- negative regulation of signal transduction structural molecule activity signal recognition particle, endoplasmic reticulum targeting /// tight junction /// membrane /// integral to membrane Dr.17167.1.A1 at -1.42428 -1.60238 -1.3058 -2.07658 1 1 1 0.99 0.99 ------Dr.17172.1.A1 at 1.285882 2.370467 3.209545 1.875623 1 0.865 0.186099 1 0.1861 ------Dr.17177.1.A1 at -2.60823 -2.94499 -3.42381 -2.40346 0.844324 0.675 0.319148 0.881 0.3191 ------Dr.17186.1.S1 at 2.163654 1.521742 1.029155 1.280519 0.978 1 1 1 0.978 zgc:56126 zgc:56126 --- response to toxin catalytic activity /// epoxide hydrolase activity microsome /// membrane Dr.17192.1.S1 at 1.281575 2.303088 2.701244 2.148563 1 0.464753 0.352887 0.893 0.3529 zgc:100870 zgc:100870------Dr.17196.1.S1 at 1.75382 2.979886 3.307769 3.090363 1 0.167338 0.110324 0.169382 0.1103 eif3j /// LOC792254 eukaryotic t------translation initiation factor activity --- Dr.17200.1.S1_at 2.852912 3.49453 2.973212 1.661298 0.331 0.116925 0.187327 1 0.1169 metrnl meteorin, g--- negative regulation of signal transduction --- extracellular region /// signal recognition particle, endoplasmic reticulum targeting Dr.17237.1.S1 at 1.432737 2.341097 2.378114 2.080439 1 0.860459 0.877847 0.994 0.8605 lap3 leucine am --- proteolysis /// protein metabolic process aminopeptidase activity /// manganese ion binding intracellular /// cytoplasm Dr.17242.1.A1 at -1.87574 -1.77127 -1.83038 -2.38844 1 1 1 0.975 0.975 zgc:76924 zgc:76924 ------nucleic acid binding /// zinc ion binding --- Dr.1725.1.A1 at 3.651512 7.088767 7.590523 3.268263 0.555 0.104238 0.123289 0.772437 0.1042 CH211-281H24.1 angiopoietin--- signal transduction receptor binding --- Dr.17250.1.A1 at -2.89165 -2.38066 -3.91525 -2.34357 0.858248 0.963 0.250721 0.986747 0.2507 ------Dr.17252.1.S1 at 2.177867 2.655381 2.982475 2.394475 0.952481 0.712853 0.352 0.763 0.352 zgc:56258 zgc:56258 ------nucleotide binding /// nucleic acid binding --- Dr.17254.1.A1 at -1.24872 -1.37749 -1.18977 2.472599 1 1 1 0.87 0.87 zgc:136263 zgc:136263------nucleus /// cytoplasm Dr.1726.1.A1 at 3.654008 4.152616 3.483667 2.654523 0.488281 0.44277 0.376492 0.802142 0.3765 nol6 nucleolar p------Dr.17267.1.A1 at 1.372193 1.002176 -1.39149 -2.12112 1 1 1 0.990497 0.9905 LOC100007669 hypothetica------Dr.17277.1.S1 at 1.543642 1.612089 1.764603 2.166523 1 1 1 0.961976 0.962 rragc Ras-related ------GTP binding nucleus /// cytoplasm Dr.17283.1.A1 at 2.26317 1.160782 -1.08458 -1.39422 0.966 1 1 1 0.966 fdps farnesyl dip--- isoprenoid biosynthetic process transferase activity --- Dr.17294.1.A1 at -2.36838 -1.91697 -1.5977 -2.39697 0.665234 1 1 0.829381 0.6652 zgc:175186 zgc:175186--- zinc ion transport zinc ion binding /// metal ion binding --- Dr.17302.1.S1 at 2.13022 4.41674 5.224127 6.648034 0.99934 0.142222 0.084948 0.070313 0.0703 mcts1 malignant T ------RNA binding --- Dr.17311.1.A1_at -1.09498 1.577536 1.775774 2.24314 1 1 1 0.916 0.916 zgc:171488 zgc:171488--- transport /// transmembrane transport transporter activity /// -specific transmembrane membrane /// integral to membrane transporter activity Dr.17323.1.S1 at -1.7474 -1.48768 -1.75981 -2.08867 1 1 1 0.996244 0.9962 zgc:110805 zgc:110805--- metabolic process methyltransferase activity /// transferase activity --- Dr.17325.1.S1_at 1.364974 1.457577 1.368827 2.110467 1 1 1 0.968904 0.9689 zgc:56530 zgc:56530 ------endopeptidase inhibitor activity /// cysteine protease inhibitor intracellular activity Dr.17326.1.A1 at 1.303246 2.035281 1.836484 2.197509 1 0.995 1 0.978959 0.979 zgc:113121 zgc:113121------Dr.17326.2.S1 at 1.116088 1.681493 1.583247 2.119305 1 1 1 0.92 0.92 zgc:113121 zgc:113121------Dr.17331.1.A1 at 1.539199 2.276718 1.675461 1.264008 1 0.844959 1 1 0.845 zgc:174863 zgc:174863------Dr.17345.1.A1 at -2.07882 -2.11233 -2.32542 -2.53218 0.998 0.997562 0.980296 0.741 0.741 ------Dr.17352.1.S1 at -1.13496 1.323495 1.516199 2.043538 1 1 1 0.974275 0.9743 CH73-159L23.2 similar to M------Dr.17354.1.S1 at 1.653499 1.929361 2.198129 2.253375 1 1 0.983888 0.975397 0.9754 LOC100007768 similar to m------Dr.17357.1.A1_at -1.12652 1.328154 1.686293 2.624734 1 1 1 0.62693 0.6269 h2afx H2A histon--- DNA repair /// DNA recombination /// nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome /// response to DNA damage stimulus /// cell cycle /// meiosis Dr.17381.1.A1_at -1.82843 -2.15485 -2.37885 -1.86788 1 0.960456 0.806 1 0.806 zgc:153957 zgc:153957--- zinc ion transport nucleic acid binding /// protein binding /// zinc ion binding /// --- metal ion binding Dr.17386.1.S1_at 1.347049 2.678558 2.266267 2.312811 1 0.123304 0.889282 0.581419 0.1233 eif2b3 eukaryotic t--- biosynthetic process translation initiation factor activity /// nucleotidyltransferase --- activity Dr.17403.1.A1 s at -1.24396 -1.42335 -1.47826 2.187294 1 1 1 0.970422 0.9704 ------Dr.17406.1.A1 at -2.29336 -1.75549 -1.64709 -1.66052 0.996879 1 1 1 0.9969 zgc:172184 zgc:172184--- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.17415.1.S1 at -3.30865 -2.83179 -2.88021 -2.84754 0.299865 0.209276 0.254416 0.32723 0.2093 zgc:56306 zgc:56306 ------insulin receptor binding --- Dr.1742.1.A1 at 2.677667 2.244272 1.312833 1.261055 0.392684 0.9997 1 1 0.3927 LOC100007667 similar to ox------Dr.17421.1.A1 at -1.16439 -1.18114 -1.07416 2.066003 1 1 1 0.992952 0.993 mybl2 myeloblasto--- regulation of transcription DNA binding nucleus Dr.17425.1.A1 at -1.9902 -2.09381 -1.66349 -1.30766 1 0.919818 1 1 0.9198 dixdc1b DIX domain ------Dr.17438.1.S1 at 2.462686 2.602615 2.162663 2.469774 0.718 0.159314 0.99321 0.31988 0.1593 LOC560548 similar to T------Dr.1744.1.A1 at 1.174884 1.315811 1.363822 2.100585 1 1 1 0.976 0.976 wu:fc25e12 wu:fc25e12------Dr.17440.1.S1 at -1.2203 -1.74784 -2.16518 -1.69894 1 1 0.991636 1 0.9916 ------Dr.17443.1.S1 at 1.558609 2.418789 2.843255 4.013717 1 0.897457 0.511638 0.177971 0.178 zgc:162207 zgc:162207--- negative regulation of nucleotide metabolic process activity mitochondrion Dr.17446.1.S1 at 1.531364 1.89842 2.081499 2.253507 1 1 1 0.760656 0.7607 LOC569801 /// phf5a hypothetica------Dr.17447.1.A1_at -1.95399 -2.73524 -3.38287 -4.39817 1 0.885558 0.628 0.376222 0.3762 zgc:77060 zgc:77060 --- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.17448.1.S1 at 1.084578 1.807532 1.92061 2.450896 1 1 1 0.301 0.301 psmd6 proteasome ------cytosol /// protein complex Dr.17450.2.S1 at -1.94953 -2.21904 -1.66421 -2.71483 1 0.915173 1 0.58541 0.5854 zgc:63663 zgc:63663 ------nucleotide binding /// ATP binding --- Dr.17453.1.A1_at -1.8628 -1.50526 -2.19554 -1.80191 1 1 0.784 1 0.784 sh2d3cb SH2 domai--- small GTPase mediated signal transduction guanyl-nucleotide exchange factor activity /// protein binding intracellular

Dr.17455.1.A1 at 1.338835 2.014903 1.576337 1.496613 1 0.999 1 1 0.999 zgc:103484 zgc:103484------Golgi apparatus Dr.17462.1.S1 at 5.806014 10.68269 7.339825 6.236994 0.047679 0.015869 0.01459 0.040248 0.0146 hyou1 hypoxia up------nucleotide binding /// ATP binding --- Dr.17464.1.A1 at -1.26397 -2.19927 -1.94682 -1.28951 1 0.979287 0.999955 1 0.9793 LOC571260 hypothetica------Dr.17471.1.S1 at 1.419551 3.403176 5.588902 2.940888 1 0.246 0.077887 0.315 0.0779 si:ch211-191i18.1 si:ch211-19------integral to membrane Dr.17475.1.A1 at -1.54807 -1.64038 -1.3759 -2.10043 1 1 1 0.991736 0.9917 ------Dr.17476.1.A1 at -1.77003 -1.19111 -3.19904 -4.09662 1 1 0.462739 0.12 0.12 hspb6 Heat shock --- response to stress ------Dr.17480.1.A1 at 1.226908 2.398031 1.639077 1.759835 1 0.570901 1 1 0.5709 zgc:56488 zgc:56488 ------Dr.17491.1.A1 at -1.54601 -2.55775 -4.33902 -1.8093 1 0.308371 0.073739 1 0.0737 pygmb phosphoryl--- carbohydrate metabolic process phosphorylase activity /// pyridoxal phosphate binding --- Dr.17491.2.S1 at -1.76128 -2.78347 -4.08 -1.73514 1 0.269 0.087119 1 0.0871 pygmb phosphoryl--- carbohydrate metabolic process phosphorylase activity /// pyridoxal phosphate binding --- Dr.17495.1.A1 at 1.424756 2.441167 2.75808 2.074973 1 0.931679 0.263388 0.978514 0.2634 zgc:56407 zgc:56407 --- transcription from RNA polymerase III promoter DNA binding /// DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex Dr.17497.1.A1 at -1.34585 -1.68535 -1.36154 -2.08267 1 1 1 0.954634 0.9546 ------Dr.1750.1.A1 at 2.483801 2.68823 1.905582 2.530829 0.970422 0.731 1 0.941539 0.731 LOC568242 similar to p------Dr.17508.1.A1_at -1.76993 -1.93841 -1.51709 -2.04076 1 1 1 0.999 0.999 zgc:63647 zgc:63647 --- metabolic process /// cellular metabolic process catalytic activity /// folic acid binding /// transferase activity ---

Dr.17509.1.S1 at -1.55281 -1.8034 -1.60975 -2.21261 1 1 1 0.88031 0.8803 zgc:56412 zgc:56412 ------Dr.17511.1.S1_at -2.17726 -2.61246 -2.76475 -2.50549 0.74991 0.131675 0.043819 0.258836 0.0438 cyp2j25 cytochrome --- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// electron carrier --- iron ion homeostasis /// oxidation reduction activity /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen /// heme binding /// metal ion binding

Dr.17519.1.S1 at 1.275436 3.397511 3.597631 3.859366 1 0.06973 0.074503 0.027276 0.0273 zgc:56526 zgc:56526 ------RNA binding /// rRNA binding intracellular /// ribonucleoprotein complex Dr.17526.1.A1_at -1.49387 -2.60557 -3.02339 -1.8288 1 0.329 0.115665 1 0.1157 itgb5 integrin, be--- cell adhesion /// cell-matrix adhesion /// integrin-mediated receptor activity /// binding /// protein binding integrin complex /// membrane /// integral to signaling pathway membrane Dr.17536.1.S1_at 1.518256 2.412322 2.736062 2.638609 1 0.140682 0.043105 0.039443 0.0394 LOC794830 /// tctp similar to T --- calcium ion transport calcium channel activity /// calcium ion binding /// calcium cytoplasm channel inhibitor activity Dr.17536.2.S1_a_at 1.940982 3.158277 3.259426 4.471584 1 0.038447 0.051115 0.026086 0.0261 rpl3 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.17536.2.S1_at 1.876237 2.624491 2.823063 3.349131 1 0.118834 0.023545 0.015587 0.0156 rpl3 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.17539.1.A1 at -12.9758 -14.4417 -7.93392 -18.7228 0.018946 0.017062 0.314702 0.020229 0.0171 ------Dr.1754.1.S1 at -1.30123 -1.79877 -2.08587 -1.86089 1 1 0.9997 1 0.9997 gstm glutathione --- metabolic process glutathione transferase activity /// transferase activity --- Dr.17553.1.S1 at 1.368188 2.130273 2.054777 1.949756 1 0.994696 1 1 0.9947 LOC100002090 similar to u------Dr.17557.1.S1_at 1.341184 1.677583 1.41665 2.839961 1 1 1 0.155406 0.1554 zgc:175182 zgc:175182--- calcium ion transport calcium channel activity /// calcium ion binding /// calcium --- channel inhibitor activity Dr.1756.1.S1_at 1.408033 2.057138 2.239963 2.129916 1 1 0.789804 0.816 0.7898 eif4a3 eukaryotic t------nucleotide binding /// nucleic acid binding /// translation --- initiation factor activity /// helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity

Dr.17569.1.A1 at 1.728761 2.354211 1.724784 1.74151 1 0.847274 1 1 0.8473 zgc:92834 zgc:92834 --- methylation nucleic acid binding /// methyltransferase activity --- Dr.17570.1.S1_at -2.36952 -2.35009 -2.24514 -2.23263 0.996882 0.994 0.99934 0.99934 0.994 mknk2b MAP kinas --- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.17570.1.S2_at -4.42329 -5.75416 -5.68038 -4.67568 0.577 0.3827 0.413275 0.492552 0.3827 mknk2b MAP kinas --- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// protein tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.17570.1.S3_at -3.68225 -3.77812 -4.16598 -2.74599 0.783 0.671 0.472 0.931245 0.472 mknk2b MAP kinas --- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// protein tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.17579.1.A1 at -2.04378 -2.8038 -1.48614 -3.33143 0.997322 0.356973 1 0.291812 0.2918 ------Dr.17580.1.A1 at -1.8568 -1.63317 -2.32401 -1.57872 1 1 0.972915 1 0.9729 LOC100005854 Hypothetica------Dr.17589.1.S1 at -1.07548 2.017156 1.586517 1.280733 1 0.997562 1 1 0.9976 zgc:153260 zgc:153260------Dr.17597.1.A1 at 1.564855 2.424355 2.676063 2.760577 1 0.659456 0.267493 0.501 0.2675 zgc:154081 zgc:154081------tRNA binding --- Dr.17605.1.S1 at 2.207957 6.687947 7.507986 5.343547 0.796 0.034563 0.016727 0.034806 0.0167 ------Dr.17610.1.A1 at 2.415437 2.590126 -1.23194 1.334979 0.943622 0.955399 1 1 0.9436 ------Dr.17614.1.A1 at -1.10331 -1.54268 -2.54166 -2.3068 1 1 0.72035 0.997322 0.7203 ------Dr.17618.1.A1 at 4.561328 15.49341 24.28391 24.39711 0.153141 0.014646 0.012987 0.011931 0.0119 kng1 kininogen 1 ------cysteine protease inhibitor activity --- Dr.17623.1.S1_at -1.38692 -2.21755 -1.72134 1.489735 1 0.95431 1 1 0.9543 foxm1l forkhead bo--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding Dr.17626.1.S1 at 1.268011 2.033585 2.615738 2.273705 1 0.9997 0.268924 0.777 0.2689 zgc:110325 zgc:110325--- DNA replication single-stranded DNA binding --- Dr.17641.1.A1 at -1.64362 -3.35638 -3.63447 -3.42433 1 0.549409 0.544204 0.590762 0.5442 zgc:158626 zgc:158626--- carbohydrate metabolic process /// metabolic process catalytic activity /// hyalurononglucosaminidase activity --- Dr.17653.1.S1 at 3.895434 3.993354 3.735423 5.89153 0.276358 0.295841 0.28018 0.083453 0.0835 zgc:91957 zgc:91957 --- metabolic process N-acetyltransferase activity --- Dr.17653.2.S1 a at 5.367511 5.122277 4.612232 7.412562 0.228634 0.199 0.214766 0.071715 0.0717 LOC100149842 /// zgc:91 hypothetica--- metabolic process N-acetyltransferase activity --- Dr.17701.1.A1 at -1.83192 -2.05341 -1.27775 -2.20929 1 0.995 1 0.989 0.989 zgc:162973 zgc:162973--- embryonic development receptor binding --- Dr.17708.1.S1 at 2.045397 2.315725 2.099167 1.966198 0.997322 0.951871 0.9997 0.999955 0.9519 exosc5 exosome co--- RNA processing 3'-5'-exoribonuclease activity /// RNA binding --- Dr.17718.2.S1 at 1.145907 2.145388 2.402606 2.1885 1 0.999 0.907 0.995 0.907 arid3b AT rich inte------DNA binding intracellular Dr.17735.1.S1 at -1.60663 -1.66802 -1.3747 -2.0192 1 1 1 0.999917 0.9999 ------Dr.17740.2.A1 at 5.715068 -1.03144 1.005273 1.003984 0.22956 1 1 1 0.2296 LOC407698 hypothetica------Dr.17742.1.A1 at -1.44421 -1.73437 -1.32216 -2.4137 1 1 1 0.712256 0.7123 ------Dr.17743.1.A1_at -1.21023 -2.55596 -3.71478 -2.69091 1 0.259136 0.058501 0.223916 0.0585 zgc:66482 zgc:66482 --- negative regulation of signal transduction --- signal recognition particle, endoplasmic reticulum targeting /// membrane /// integral to membrane Dr.17748.1.A1 at -1.7492 -1.9103 -1.28245 -2.19449 1 1 1 0.88031 0.8803 ------Dr.17755.1.A1 at 1.104997 1.944612 1.803924 2.693763 1 0.999955 1 0.122982 0.123 LOC559410 similar to F------Dr.17766.1.A1 at -1.36249 -1.67349 -1.51347 -2.11442 1 1 1 0.999325 0.9993 spns2 spinster ho------Dr.17775.1.A1 at -1.50971 -2.045 -1.4849 -2.13978 1 1 1 0.978177 0.9782 wu:fa99c11 wu:fa99c11------Dr.1778.1.S1 at 1.367206 2.086754 1.689416 1.392209 1 0.998 1 1 0.998 sdcbp syndecan b--- response to hypoxia protein binding --- Dr.17784.1.A1 at 4.158304 10.18967 16.49732 23.2954 0.080491 0.019593 0.010467 0.008526 0.0085 ------Dr.17808.1.S1 at 1.25142 -2.00962 -2.13485 -2.43344 1 0.999955 0.898232 0.407464 0.4075 wu:fb77e12 wu:fb77e12------Dr.17818.1.S1 at 1.47234 2.114979 1.769911 1.676856 1 0.943 1 1 0.943 rnd3a Rho family --- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular /// membrane Dr.17820.1.S1 at -2.09934 -2.34065 -2.64704 -2.61376 1 0.960456 0.668079 0.88031 0.6681 ------Dr.17830.1.S1_at 1.321195 2.264141 2.431921 2.963048 1 0.957423 0.813 0.331444 0.3314 zgc:55347 zgc:55347 --- response to biotic stimulus /// regulation of signal ------transduction Dr.17833.1.A1 at 3.165536 5.169692 4.992372 4.443258 0.102515 0.028278 0.031065 0.03981 0.0283 wu:fc60b09 wu:fc60b09------Dr.17839.1.A1 at 1.029926 1.248037 1.476519 2.290951 1 1 1 0.898232 0.8982 ------Dr.17866.1.S1 at 4.416018 8.024852 5.092861 4.056886 0.062971 0.016947 0.030378 0.058901 0.0169 wu:fa12f04 wu:fa12f04 ------Dr.17874.1.A1 at 1.398222 1.801517 2.378679 2.995611 1 1 0.92568 0.34353 0.3435 ------Dr.17876.1.S1 at 1.34219 1.782202 1.805106 2.226013 1 1 1 0.911484 0.9115 zgc:112025 zgc:112025------Dr.1788.1.A1 at 2.498357 2.043201 1.497404 1.492204 0.871796 1 1 1 0.8718 wu:fc56c11 wu:fc56c11------Dr.17883.1.S1_at -1.1318 -1.10028 1.446236 2.126773 1 1 1 0.858934 0.8589 cdk2 cyclin-depe--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.17885.1.S1 at -1.23094 1.448228 1.950884 2.73082 1 1 1 0.572 0.572 ------Dr.17890.3.A1_at 1.030969 1.588901 1.572158 2.291275 1 1 1 0.923812 0.9238 zgc:85723 Zgc:85723 ------structural molecule activity tight junction /// membrane /// integral to membrane Dr.17896.1.A1_at -1.90817 -2.37137 -2.23158 -2.65543 1 0.9997 0.9997 0.988927 0.9889 nrarpb Notch-regu--- transcription /// transcription termination /// regulation of ------transcription, DNA-dependent /// Notch signaling pathway /// multicellular organismal development /// transcription antitermination Dr.17898.1.S1 at -1.59852 -1.9973 -2.21146 -2.1464 1 1 0.980244 0.99321 0.9802 LOC566847 similar to P------Dr.1791.1.S1 at 1.868487 3.611944 2.77464 1.831697 1 0.267493 0.748368 1 0.2675 pdap1 pdgfa asso------Dr.17912.1.S1 at -2.0821 -3.49894 -4.98694 -3.15538 0.994582 0.152297 0.064545 0.350585 0.0645 ------Dr.17935.1.S1 at -1.18911 -1.1324 1.000454 2.46139 1 1 1 0.278233 0.2782 im:6898523 im:6898523------Dr.1794.1.A1 at -2.09912 -2.14111 -2.09135 -2.09036 0.99994 0.998 0.999955 0.998 0.998 parva parvin, alph------Dr.17940.1.A1 at 2.97252 2.738259 2.199309 1.425115 0.07994 0.407833 0.99934 1 0.0799 ------Dr.17955.1.S1 at 1.25058 2.508327 2.539731 2.049581 1 0.113684 0.803752 0.95265 0.1137 ------Dr.17957.1.A1 at -1.64253 -1.99714 -1.78517 -2.09549 1 0.999917 1 0.968824 0.9688 ------Dr.17962.1.A1 at -1.70379 -1.97507 -2.17971 -1.689 1 0.996244 0.99934 1 0.9962 ------Dr.17971.1.S1 at -2.17584 -2.45156 -2.58598 -1.86829 1 0.904 0.644 1 0.644 ------Dr.17997.1.S1_at 1.237618 1.791877 1.86705 2.284098 1 1 1 0.620851 0.6209 polr2j polymerase --- transcription DNA binding /// DNA-directed RNA polymerase activity /// --- protein dimerization activity Dr.18003.1.S1 at -1.38214 -1.82938 -2.1193 -1.54406 1 1 0.9997 1 0.9997 ------Dr.18007.1.S1 at 1.201384 1.686564 1.858585 2.899369 1 1 1 0.195143 0.1951 zgc:162244 zgc:162244------membrane /// integral to membrane Dr.18010.1.S1 at -1.44919 -1.74529 -1.42857 -2.1725 1 1 1 0.997 0.997 ------Dr.18018.1.A1 at -1.28104 -1.18718 -1.23445 3.353016 1 1 1 0.157091 0.1571 wu:fd18f09 wu:fd18f09 ------Dr.18032.1.S1 at 1.166858 2.08851 1.964961 1.679935 1 0.976293 1 1 0.9763 ------Dr.18034.1.A1 at 3.60181 3.71618 3.96504 3.811671 0.056742 0.0897 0.051586 0.02444 0.0244 zgc:112104 zgc:112104------calcium ion binding --- Dr.1805.1.A1_at -2.04011 -1.11929 -1.05869 -1.23282 0.988847 1 1 1 0.9888 slc25a43 solute carri--- transport /// metabolic process transporter activity /// binding /// oxidoreductase activity mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.18052.1.S1 at 3.459398 4.162712 4.605825 3.451411 0.167 0.065251 0.060492 0.154566 0.0605 znf593 zinc finger ------zinc ion binding intracellular Dr.18055.1.S1 at 2.412714 2.214132 2.18143 1.270667 0.728556 0.345974 0.734322 1 0.346 ------Dr.18079.1.S1 at 1.588883 2.134011 2.550207 2.978406 1 0.9997 0.931245 0.618659 0.6187 ------Dr.18088.1.S1 at 2.44253 2.928568 2.661292 1.650609 0.843 0.539 0.728767 1 0.539 zgc:73292 zgc:73292 ------membrane /// integral to membrane Dr.1809.1.A1 at 2.556764 4.516558 3.117992 3.540132 0.633509 0.589604 0.911 0.185881 0.1859 calrl2 calreticulin, --- protein folding calcium ion binding /// unfolded protein binding endoplasmic reticulum Dr.18092.1.A1 at -1.95135 -1.88208 -1.85097 -2.61654 1 1 1 0.81175 0.8117 wu:fd07d09 wu:fd07d09------Dr.18093.1.S1 at 1.483818 1.194275 1.080549 5.266689 1 1 1 0.093427 0.0934 ------Dr.181.1.S1 at -1.20162 -1.42594 -2.16819 -1.54112 1 1 0.987598 1 0.9876 wu:fa04g05 wu:fa04g05------Dr.1810.1.A1 at 1.612685 1.98223 2.460292 1.985875 1 1 0.906694 1 0.9067 ------Dr.1811.1.S1_at -1.24474 -1.2105 -1.02226 3.580504 1 1 1 0.038183 0.0382 CH211-167B20.5 suppressor --- chromatin assembly or disassembly /// chromatin chromatin binding /// methyltransferase activity /// zinc ion chromatin /// nucleus modification binding /// transferase activity /// histone-lysine N- methyltransferase activity Dr.18112.2.A1 at 1.349697 1.817563 1.521974 2.326993 1 1 1 0.764471 0.7645 LOC794796 /// zgc:10107 hypothetica------Dr.18123.1.A1 at -2.13629 -2.51329 -1.90169 -2.37894 1 0.978746 1 0.982587 0.9787 ------Dr.18130.1.S1 at -1.3633 -1.84578 -1.87252 -2.09247 1 1 1 0.99934 0.9993 ------Dr.18130.2.A1 at -1.94992 -2.36715 -2.49809 -2.16562 1 0.9997 0.991811 0.999955 0.9918 ------Dr.18132.1.A1 at -2.34657 -2.20754 -3.26793 -2.35246 0.850713 0.976443 0.209405 0.825414 0.2094 ------Dr.18135.1.A1 at -1.45909 -1.12685 -1.06849 13.87648 1 1 1 0.020186 0.0202 rtkn2 rhotekin 2 ------Dr.1815.1.A1_at 1.609259 3.375904 3.237102 3.813312 1 0.065132 0.074769 0.049496 0.0495 macf1 microtubule--- calcium ion transport /// cell cycle arrest actin binding /// calcium channel activity /// calcium ion --- binding /// calcium channel inhibitor activity Dr.18150.1.S1 at 2.077252 3.169322 3.11376 3.439776 0.997562 0.165708 0.272 0.216992 0.1657 zgc:101680 zgc:101680--- RNA processing 3'-5'-exoribonuclease activity /// RNA binding --- Dr.18151.1.S1 at 1.111894 1.342642 1.503995 2.513733 1 1 1 0.350868 0.3509 LOC798783 hypothetica------Dr.1817.1.A1 at 1.238804 -3.06502 -4.10973 -3.10987 1 0.788748 0.250543 0.51 0.2505 rcan3 regulator of --- calcium-mediated signaling ------Dr.18179.1.A1_at 1.395379 1.649026 1.722115 2.781518 1 1 1 0.858966 0.859 LOC791464 hypothetica--- protein folding peptidyl-prolyl cis-trans isomerase activity /// protein binding --- /// isomerase activity Dr.18213.1.A1 at 1.925739 2.795437 2.875284 2.381533 1 0.182 0.176403 0.551 0.1764 LOC570617 similar to n------Dr.18222.1.A1 at 2.304835 3.724702 2.436913 1.571872 0.814 0.091427 0.859 1 0.0914 LOC793886 similar to p------Dr.18229.1.A1_at -1.75821 -1.98949 -1.57893 -2.15783 1 1 1 0.99934 0.9993 LOC560549 similar to R--- protein amino acid phosphorylation protein serine/threonine kinase activity /// protein tyrosine --- kinase activity /// ATP binding Dr.18230.1.A1 at 1.426239 2.152182 1.504856 1.44474 1 0.99 1 1 0.99 LOC795255 similar to s------Dr.18239.2.A1 at -1.4055 -1.6115 -1.34983 -2.12044 1 1 1 0.980398 0.9804 ------Dr.18245.1.S1 at -1.13138 1.424716 2.078147 9.229862 1 1 0.9997 0.049542 0.0495 LOC100002400 similar to N------Dr.18257.1.A1 at -2.02824 -2.12598 -2.29238 -2.68954 1 0.837631 0.738483 0.418385 0.4184 LOC558098 similar to z------Dr.18257.2.S1 at -1.67982 -2.06356 -2.06232 -2.33188 1 0.999955 0.9997 0.552154 0.5522 LOC558098 similar to z------Dr.18266.1.S1 at -1.1307 -1.15963 -1.11318 6.445057 1 1 1 0.039543 0.0395 zgc:55664 zgc:55664 ------Dr.18269.1.A1 at -2.5357 -2.55569 -2.77224 -2.01434 0.995 0.968307 0.876 0.999955 0.876 ------Dr.1827.1.A1 at 1.715039 3.116062 3.141435 3.302892 1 0.252645 0.252974 0.220544 0.2205 LOC564632 similar to u------Dr.18271.1.S1 at -1.46464 -2.11986 -1.64914 -2.33696 1 0.997322 1 0.883942 0.8839 ------Dr.18272.1.S1 at -1.65622 -2.11039 -2.40795 -1.90987 1 0.998 0.643836 1 0.6438 rgma RGM doma------anchored to plasma membrane Dr.18282.2.S1_at 1.48821 2.494813 3.095485 4.280227 1 0.929438 0.36641 0.115415 0.1154 rps7 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.18282.3.S1 at -1.34803 -1.8474 -3.75375 -2.47168 1 1 0.107075 0.548 0.1071 sparc secreted ac------calcium ion binding --- Dr.18282.3.S2 at 2.066156 4.443737 5.587316 8.490106 0.999 0.036281 0.030047 0.011133 0.0111 zgc:92237 zgc:92237 --- translation structural constituent of ribosome intracellular /// ribosome Dr.18282.6.A1 at 2.402855 3.136571 2.14507 1.38365 0.728924 0.195486 0.99934 1 0.1955 wu:fb79g11 wu:fb79g11------Dr.18282.8.A1_at -1.98286 -2.12141 -2.05893 -2.21514 1 0.999955 0.999955 0.99994 0.9999 st8sia1 ST8 alpha- --- protein amino acid glycosylation /// metabolic process alpha-N-acetylneuraminate alpha-2,8-sialyltransferase Golgi apparatus /// membrane /// integral to activity /// alpha-N-acetylneuraminate alpha-2,8- membrane /// integral to Golgi membrane sialyltransferase activity /// sialyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups Dr.18287.1.S1_at 1.411241 1.798626 2.457971 2.983064 1 1 0.525715 0.170633 0.1706 cx43.4 connexin 4 --- cell communication --- plasma membrane /// gap junction /// connexon complex /// membrane /// integral to membrane /// cell junction Dr.18290.1.A1_at 2.042598 4.761507 6.670856 5.516754 0.998 0.072553 0.023545 0.051756 0.0235 LOC100150664 /// met similar to m--- protein amino acid phosphorylation /// multicellular nucleotide binding /// protein kinase activity /// protein membrane /// integral to membrane organismal development tyrosine kinase activity /// receptor activity /// calcium ion binding /// ATP binding /// kinase activity /// transferase activity Dr.18294.1.S1_at -2.81346 -2.63741 -3.09179 -2.54285 0.264569 0.410856 0.120408 0.534 0.1204 ptgs1 prostagland--- vasculogenesis /// kidney development /// response to peroxidase activity /// peroxidase activity /// prostaglandin- --- oxidative stress /// response to chemical stimulus /// endoperoxide synthase activity /// oxidoreductase activity /// oxidation reduction heme binding Dr.18300.1.S1 at 2.376138 3.999084 3.620679 2.893321 0.369518 0.009084 0.016548 0.136201 0.0091 dt1p1a10l hypothetica--- rRNA processing ------Dr.1831.1.S1_at -1.53105 -1.78704 -2.19872 -2.0996 1 1 0.521669 0.99556 0.5217 lfng lunatic fring--- Notch signaling pathway /// multicellular organismal transferase activity /// transferase activity, transferring Golgi membrane /// Golgi apparatus /// development /// nervous system development /// cell glycosyl groups /// O-fucosylpeptide 3-beta-N- membrane /// integral to membrane differentiation /// hypochord development acetylglucosaminyltransferase activity Dr.18311.1.S1 at 1.865133 3.18103 3.696036 2.228634 1 0.458196 0.148815 0.931881 0.1488 si:ch211-245h7.2 si:ch211-24------Dr.18312.1.S1_at 1.15703 1.748755 1.731319 2.15187 1 1 1 0.989 0.989 u2af1 U2(RNU2) ------nucleotide binding /// nucleic acid binding /// RNA binding /// nucleus zinc ion binding Dr.18314.1.A1_at 1.371332 2.077012 2.055445 1.93486 1 0.997 0.998 1 0.997 smarca5 SWI/SNF r--- ATP-dependent chromatin remodeling /// retina nucleic acid binding /// DNA binding /// helicase activity /// chromatin remodeling complex development in camera-type eye ATP binding /// nucleosome binding Dr.18315.1.S1_at 1.447627 3.291391 3.811504 4.181978 1 0.026313 0.083898 0.021061 0.0211 eef1g eukaryotic t--- translation /// translational elongation translation elongation factor activity eukaryotic translation elongation factor 1 complex Dr.18318.1.S1 at 1.05999 1.741161 1.980977 2.408456 1 1 0.999955 0.939238 0.9392 snrpc small nucle------nucleic acid binding /// zinc ion binding nucleus /// ribonucleoprotein complex Dr.18319.2.A1 at 2.758943 2.83846 3.231075 4.290398 0.347238 0.287668 0.185629 0.053046 0.053 LOC569471 similar to c ------Dr.18321.1.S1 at -2.43708 -3.02164 -2.72237 -5.06645 0.999955 0.98016 0.977 0.624 0.624 scarb2 scavenger --- cell adhesion receptor activity lysosome /// membrane Dr.18323.1.S1_at 1.430272 2.126142 2.111884 1.830523 1 0.983688 0.99934 1 0.9837 adss adenylosuc--- purine nucleotide biosynthetic process nucleotide binding /// magnesium ion binding /// --- adenylosuccinate synthase activity /// GTP binding /// ligase activity /// metal ion binding Dr.18330.1.S1 at 3.487361 4.120161 3.728372 3.242823 0.23425 0.157451 0.122146 0.278605 0.1221 noc3l nucleolar c------binding nucleus Dr.18334.1.A1_at 2.036344 2.943794 2.780396 2.033619 0.988927 0.111263 0.182479 0.999917 0.1113 cars cysteinyl-tR--- translation /// cysteinyl-tRNA aminoacylation nucleotide binding /// cysteine-tRNA ligase activity /// ATP cytoplasm binding Dr.18341.1.S1_at 1.985708 9.927116 11.6574 12.99146 0.999955 0.009851 0.018103 0.011185 0.0099 nrp2b neuropilin 2--- vasculogenesis /// neural crest cell migration /// cell --- membrane adhesion /// axon guidance /// axonal fasciculation /// regulation of vascular endothelial growth factor receptor signaling pathway Dr.18344.1.A1 at 3.754555 4.891768 5.863178 8.05905 0.473247 0.277652 0.230579 0.109091 0.1091 smtn Smoothelin ------Dr.18346.1.A1 at -1.19524 -2.63088 -2.94722 -2.67255 1 0.063562 0.198509 0.296385 0.0636 zgc:158626 zgc:158626--- carbohydrate metabolic process /// metabolic process catalytic activity /// hyalurononglucosaminidase activity --- Dr.18357.1.A1 at 3.238429 4.226134 3.591989 4.020533 0.128814 0.043383 0.10895 0.038499 0.0385 LOC100005596 similar to C------Dr.18372.1.A1 at -1.28008 -1.37282 -1.27007 -2.12861 1 1 1 0.99994 0.9999 si:dkey-105o6.2 si:dkey-105--- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.18374.1.A1 at -2.75852 -2.99831 -2.99791 -3.29456 0.78997 0.343153 0.342426 0.435458 0.3424 ------Dr.18375.1.S1 at -2.54501 -1.99503 -1.41911 -1.57327 0.835 1 1 1 0.835 ------Dr.18377.1.S1_at 1.509259 2.184045 2.653434 2.530362 1 0.999 0.677551 0.755 0.6776 LOC100004912 /// mrpl14 similar to m--- translation structural constituent of ribosome intracellular /// mitochondrion /// ribosome /// ribonucleoprotein complex Dr.18386.1.A1 at 1.325735 2.188563 1.724944 1.559365 1 0.769 1 1 0.769 LOC798345 similar to S------Dr.1839.1.A1 at 4.948414 4.608155 5.086954 3.988388 0.026488 0.023286 0.031812 0.08373 0.0233 LOC792986 similar to z --- metal ion transport metal ion transmembrane transporter activity membrane Dr.18396.1.S1 at 1.307575 -1.02567 1.22281 2.504008 1 1 1 0.683 0.683 txnip thioredoxin ------Dr.184.1.S1_at 1.839353 2.466797 1.4666 1.368882 1 0.506355 1 1 0.5064 b2m beta-2-micr --- antigen processing and presentation of peptide antigen via --- extracellular region /// signal recognition MHC class I /// immune response /// negative regulation of particle, endoplasmic reticulum targeting /// signal transduction MHC class I protein complex Dr.18401.2.A1_at 2.22823 2.251337 1.739098 1.815345 0.992 0.980565 1 1 0.9806 tk2 thymidine k--- nucleobase, nucleoside, nucleotide and nucleic acid ATP binding /// kinase activity /// phosphotransferase --- metabolic process activity, alcohol group as acceptor Dr.18412.1.S1_at 2.153327 2.744393 2.805497 2.415181 0.493343 0.086858 0.09638 0.083554 0.0836 CH211-190N7.2 /// slc30a solute carri--- transport /// ion transport /// cation transport /// zinc ion zinc ion transmembrane transporter activity /// zinc ion Golgi apparatus /// membrane /// integral to transport /// zinc ion transport binding /// cation transmembrane transporter activity membrane Dr.18414.1.S1 at -1.78049 -1.7611 -1.416 -2.09135 1 1 1 0.993617 0.9936 pdcd4a programme------Dr.18415.1.A1_at -2.09957 -2.52752 -1.87985 -2.09228 0.96 0.048191 1 0.972 0.0482 apoa1bp apolipoprot--- negative regulation of signal transduction --- extracellular region /// signal recognition particle, endoplasmic reticulum targeting Dr.18416.1.A1 at -1.61256 -2.15938 -2.29031 -1.39104 1 0.919 0.523191 1 0.5232 selenbp1 selenium b--- transport /// protein transport selenium binding nucleus /// cytoplasm /// membrane Dr.18433.1.A1_at 3.275618 4.069388 2.97798 2.165833 0.222904 0.137165 0.34999 0.992952 0.1372 usp42 ubiquitin sp--- protein amino acid phosphorylation /// N-terminal protein nucleotide binding /// translation initiation factor activity /// --- myristoylation /// ubiquitin-dependent protein catabolic ubiquitin thiolesterase activity /// glycylpeptide N- process tetradecanoyltransferase activity /// protein kinase activity /// protein serine/threonine kinase activity /// protein tyrosine kinase activity /// endopeptidase inhibitor activity /// ATP binding /// peptidase activity /// cysteine-type peptidase activity /// kinase activity /// transferase activity /// hydrolase activity Dr.18442.1.A1 at -1.70502 -2.015 -1.51399 -2.59788 1 1 1 0.278418 0.2784 zgc:152984 zgc:152984------protein binding --- Dr.18470.1.A1_at 1.668221 1.021517 -1.55547 -2.3002 1 1 1 0.859 0.859 zgc:113035 Zgc:11303 --- cell adhesion /// negative regulation of signal transduction protein binding signal recognition particle, endoplasmic reticulum targeting /// plasma membrane /// membrane /// integral to membrane Dr.1848.1.A1_a_at 1.677641 1.996454 2.103064 1.329005 1 1 0.986747 1 0.9867 wu:fc91a05 /// zgc:66298 wu:fc91a05 --- transcription /// transcription termination /// regulation of DNA binding /// DNA-directed RNA polymerase activity /// nucleus transcription, DNA-dependent /// transcription transferase activity /// nucleotidyltransferase activity antitermination Dr.18486.1.A1_at -1.89208 -2.36422 -2.29065 -2.43948 1 0.929 0.985663 0.96 0.929 pkz protein kina--- protein amino acid phosphorylation nucleotide binding /// left-handed Z-DNA binding /// RNA --- binding /// double-stranded RNA adenosine deaminase activity /// protein kinase activity /// protein kinase activity /// protein kinase activity /// protein serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity /// phosphopantetheine binding

Dr.185.1.A1 at 1.889083 -1.54993 -2.17977 -1.47631 1 1 0.968799 1 0.9688 wu:fa04h02 wu:fa04h02------Dr.18503.1.A1 at -2.05701 -1.89733 -1.66223 -2.07918 0.98838 1 1 0.992263 0.9884 zgc:66407 zgc:66407 ------nucleic acid binding /// zinc ion binding intracellular Dr.18509.1.A1_at 2.109844 2.961267 3.340769 3.557974 0.999955 0.260878 0.107425 0.09539 0.0954 mrpl15 mitochondr--- translation structural constituent of ribosome intracellular /// mitochondrion /// ribosome /// large ribosomal subunit /// ribonucleoprotein complex Dr.18512.1.A1 at 2.217185 1.433994 1.297234 1.549414 0.836683 1 1 1 0.8367 wdfy2 WD repeat --- zinc ion transport zinc ion binding /// metal ion binding --- Dr.18514.1.S1 at -2.5462 -1.83542 -1.30208 1.319084 0.964416 1 1 1 0.9644 zgc:101025 /// zgc:92739 zgc:101025 ------Dr.18536.1.A1 at 1.662322 3.576275 4.55235 3.321016 1 0.145541 0.06847 0.235345 0.0685 LOC793507 similar to fr------Dr.1854.1.A1 at -1.14611 -1.57151 -1.55759 -2.21048 1 1 1 0.872327 0.8723 wu:fc96c10 wu:fc96c10------Dr.18554.1.A1 at 1.375272 1.784663 1.730862 2.083192 1 1 1 0.996244 0.9962 LOC794395 similar to A ------Dr.18562.1.A1_a_at 2.867064 3.934014 2.66611 2.068411 0.062281 0.140289 0.084256 0.99556 0.0623 fpgs folylpolyglu--- biosynthetic process /// folic acid and derivative biosynthetic tetrahydrofolylpolyglutamate synthase activity /// ATP binding --- process /// ligase activity Dr.18562.2.A1_at 1.575842 2.650563 1.937873 1.370722 1 0.613935 1 1 0.6139 fpgs Folylpolyglu--- biosynthetic process /// folic acid and derivative biosynthetic tetrahydrofolylpolyglutamate synthase activity /// ATP binding --- process /// ligase activity Dr.18562.2.A1_x_at 1.924314 2.704639 2.174902 1.623732 1 0.552724 0.955495 1 0.5527 fpgs Folylpolyglu--- biosynthetic process /// folic acid and derivative biosynthetic tetrahydrofolylpolyglutamate synthase activity /// ATP binding --- process /// ligase activity Dr.18589.1.A1 at 1.193049 1.404431 1.132643 2.087777 1 1 1 0.96 0.96 ------Dr.18598.1.A1 at -1.37543 -1.6767 -2.35358 -2.65865 1 1 0.918 0.667121 0.6671 si:dkey-85n7.3 si:dkey-85n------binding --- Dr.18614.1.A1 at 2.696051 3.594356 1.949892 1.084344 0.779087 0.414 1 1 0.414 ------Dr.18623.1.S1 at -2.44238 -2.95219 -2.4714 -2.42914 0.586464 0.378461 0.646511 0.542725 0.3785 ------Dr.18626.1.A1_at -2.04079 -2.13241 -1.62995 -1.97383 0.999955 0.972517 1 0.999955 0.9725 si:dkey-170m15.2 si:dkey-170--- proteolysis calcium-dependent cysteine-type endopeptidase activity intracellular

Dr.18643.1.A1 at -1.76309 -1.96882 -2.31803 -3.7307 1 1 0.714863 0.330463 0.3305 ------Dr.18650.1.S1 at -1.33962 -1.84534 -1.66144 -2.12238 1 1 1 0.99934 0.9993 ------Dr.18656.1.S1 at -1.74261 -1.74296 -2.11895 -1.80267 1 1 0.996712 1 0.9967 ------Dr.18688.1.A1 at -1.39758 -1.6814 -2.11456 -1.72762 1 1 0.985921 1 0.9859 znf513 zinc finger ------Dr.18696.1.S1 at -1.79966 -1.87957 -1.46357 -2.20393 1 1 1 0.987421 0.9874 c20orf11 c20orf11 h------Dr.187.1.A1 at 2.172218 2.729382 2.768246 2.042433 0.924626 0.323375 0.381514 1 0.3234 zgc:153990 zgc:153990------Dr.18718.1.A1 at -1.33314 -2.67952 -2.8774 -2.35526 1 0.887363 0.61434 0.907 0.6143 ------Dr.18722.1.A1 at -1.69253 -2.20031 -1.36012 -2.73614 1 0.982513 1 0.536618 0.5366 ------Dr.18735.1.A1_at 1.587391 2.109292 2.602252 3.088633 1 0.995 0.946 0.566571 0.5666 ap1s1 adaptor-rela--- transport /// intracellular protein transport /// protein protein binding /// protein binding /// protein transporter membrane coat /// clathrin coat of trans-Golgi transport /// vesicle-mediated transport activity network vesicle /// clathrin adaptor complex

Dr.18765.1.A1 at -1.04422 -1.13899 1.006257 2.929165 1 1 1 0.43709 0.4371 lrrc15 leucine rich ------protein binding --- Dr.18773.2.A1 at 1.382462 2.537736 2.122036 2.095921 1 0.525 0.953849 0.993617 0.525 klhdc4 kelch doma------Dr.18787.1.A1 at -1.52762 -1.44512 -1.04206 -2.24984 1 1 1 0.944 0.944 LOC100006295 hypothetica------Dr.188.1.A1_at 1.643109 1.782979 1.960455 2.635547 1 1 1 0.119694 0.1197 gtf2h4 general tran--- DNA repair /// regulation of transcription, DNA-dependent RNA polymerase II transcription factor activity nucleus

Dr.18817.1.A1 at -1.64335 -1.85766 -1.40472 -2.27312 1 1 1 0.815 0.815 ------Dr.18836.3.S1_at -1.58526 -2.22051 -2.06215 -2.18423 1 0.792505 0.995 0.939238 0.7925 sox3 SRY-box c--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity nucleus transcription, DNA-dependent /// multicellular organismal development /// transcription antitermination /// positive regulation of transcription factor activity

Dr.18852.1.A1 at -1.51611 -1.80524 -1.2854 -2.08732 1 1 1 0.994659 0.9947 ------Dr.18867.1.S1 at -2.10706 -2.34408 -1.82244 -2.42142 0.800602 0.312583 1 0.23655 0.2366 LOC553507 hypothetica------nucleic acid binding nucleus Dr.18903.1.A1 at -2.45738 -2.54604 -2.35414 -2.55608 0.857597 0.78997 0.934 0.783 0.783 ------Dr.18925.1.A1 at -1.73334 -1.64929 -2.30316 -2.82664 1 1 0.823937 0.341236 0.3412 ------Dr.18930.1.A1 at -1.74933 -2.10705 -1.70183 -1.94631 1 0.996552 1 1 0.9966 wu:fb72e05 wu:fb72e05------Dr.18944.1.S1 at 1.043023 1.172178 1.228413 2.267485 1 1 1 0.913 0.913 ------Dr.1899.2.A1 at 1.91455 2.176583 1.90494 2.09453 0.99994 0.803752 1 0.784311 0.7843 zgc:85948 zgc:85948 ------RNA binding --- Dr.19009.1.A1 at -1.78216 -2.02666 -1.37423 -2.12309 1 0.999955 1 0.998 0.998 dlgap1 discs, large --- cell-cell signaling --- membrane /// synapse Dr.19026.1.A1 at -2.08687 -2.43378 -1.7836 -3.00721 0.996712 0.754502 1 0.613609 0.6136 ------Dr.1904.1.S1_at -2.15457 -3.76706 -4.60425 -3.07343 0.952481 0.067705 0.048193 0.020601 0.0206 aldh9a1a aldehyde d --- metabolic process /// oxidation reduction aldehyde dehydrogenase (NAD) activity /// oxidoreductase cytoplasm activity Dr.19062.1.S1 at -1.26283 -2.71099 -3.61059 -2.50316 1 0.33983 0.016257 0.126621 0.0163 ------Dr.19069.1.A1 at 2.650602 2.347451 1.394381 1.292287 0.543637 0.893407 1 1 0.5436 ------Dr.19097.1.A1 at -1.60931 -2.00378 -1.34425 -2.41493 1 1 1 0.658727 0.6587 wu:fc57b04 wu:fc57b04------Dr.19099.1.A1 at 2.075368 1.541883 1.480424 -1.08976 0.99934 1 1 1 0.9993 aga aspartylglu ------hydrolase activity --- Dr.19117.1.S1_at -1.89549 -1.93026 -1.29194 -2.11622 1 1 1 0.977 0.977 zgc:123304 zgc:123304------hydrolase activity lysosome /// lysosomal membrane /// endosome /// membrane /// integral to membrane /// late endosome membrane Dr.19144.1.A1_at -2.36702 -1.38224 -1.64742 -1.04556 0.958311 1 1 1 0.9583 p4ha2 procollagen--- protein metabolic process /// collagen catabolic process binding /// iron ion binding /// oxidoreductase activity /// --- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Dr.1917.1.A1 at -2.81819 -3.86609 -3.92284 -2.15072 0.042064 0.12242 0.049496 0.026008 0.026 wu:fz74f10 wu:fz74f10 ------Dr.1920.1.S1 at 1.483511 2.05828 1.914576 1.933581 1 0.962505 1 1 0.9625 derl1 Der1-like d------Dr.19202.1.S1_at -1.09695 -2.14803 -2.1663 -2.66513 1 0.996712 0.998 0.83 0.83 enpp6 ectonucleot--- metabolic process /// negative regulation of signal catalytic activity /// hydrolase activity signal recognition particle, endoplasmic transduction /// lipid catabolic process reticulum targeting /// plasma membrane /// membrane /// integral to membrane Dr.1921.1.A1 at 3.559025 3.325541 2.1543 1.816027 0.460845 0.442597 0.952674 1 0.4426 wu:fb09g03 wu:fb09g03------Dr.19214.1.A1 at -1.88677 -1.98515 -1.57119 -3.41229 1 1 1 0.251495 0.2515 ------Dr.19222.1.S2_at -1.2888 -2.67401 -2.32133 -1.82412 1 0.418385 0.417713 1 0.4177 fgfr2 fibroblast g--- protein amino acid phosphorylation /// negative regulation of nucleotide binding /// protein kinase activity /// protein signal recognition particle, endoplasmic signal transduction tyrosine kinase activity /// transmembrane receptor protein reticulum targeting /// membrane /// integral to tyrosine kinase activity /// receptor activity /// ATP binding /// membrane kinase activity /// transferase activity /// fibroblast growth factor binding Dr.19223.1.S1_at -1.41975 -1.77667 -2.93888 -2.10205 1 1 0.403162 0.992263 0.4032 aldoc aldolase c, --- glycolysis /// metabolic process catalytic activity /// fructose-bisphosphate aldolase activity /// --- lyase activity Dr.19228.1.A1 at -1.55985 -1.9202 -1.40897 -2.38489 1 1 1 0.580543 0.5805 ------Dr.19274.1.S2_at 1.474557 2.32624 2.338801 2.401266 1 0.701 0.790486 0.600187 0.6002 ddx19 DEAD/H (A------nucleic acid binding /// helicase activity /// ATP binding /// --- ATP-dependent helicase activity /// hydrolase activity

Dr.1928.1.A1 at 2.959331 5.347027 5.380231 4.100347 0.512 0.07178 0.07 0.144 0.07 wu:fb36b12 wu:fb36b12------Dr.19284.1.S1_at -1.13446 -1.57677 -2.09552 -2.29501 1 1 0.991 0.96723 0.9672 zgc:113028 zgc:113028--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// ATP binding ---

Dr.193.1.S1_at -2.40915 -3.74192 -3.47336 -2.54841 0.361363 0.218358 0.046385 0.417141 0.0464 raraa retinoic acid--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// retinoic acid receptor activity /// transcription antitermination receptor activity /// ligand-dependent nuclear receptor activity /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.19303.1.A1 at 1.46845 2.939996 1.533356 1.648132 1 0.558 1 1 0.558 ppp1r13l protein pho------Dr.19345.1.A1 at 2.146978 2.588019 2.754514 1.892275 0.99994 0.715 0.467845 1 0.4678 imp4 IMP4, U3 s------nucleic acid binding /// hydrolase activity ribonucleoprotein complex Dr.19380.1.S1_at -1.34438 -1.29104 2.545046 9.319738 1 1 0.859 0.014588 0.0146 tmsb thymosin, b--- cytoskeleton organization and biogenesis /// actin actin binding cytoplasm /// cytoskeleton cytoskeleton organization and biogenesis /// sequestering of actin monomers Dr.194.1.S1_at -1.92756 -2.38129 -1.86584 -1.8744 1 0.915173 1 1 0.9152 rarga retinoic acid--- transcription /// transcription termination /// regulation of DNA binding /// DNA binding /// transcription factor activity nucleus /// nucleus transcription, DNA-dependent /// regulation of transcription, /// steroid hormone receptor activity /// retinoic acid receptor DNA-dependent /// zinc ion transport /// transcription activity /// retinoic acid receptor activity /// receptor activity /// antitermination ligand-dependent nuclear receptor activity /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding

Dr.19411.1.A1 at -1.46862 -1.73651 -1.47947 -2.19415 1 1 1 0.940342 0.9403 ------Dr.1942.1.A1 at -1.33796 -1.84867 -2.20587 -2.25999 1 1 0.913 0.841361 0.8414 LOC566443 hypothetica------Dr.19427.2.S1 at -1.75802 -1.80963 -1.89253 -2.48081 1 1 1 0.899812 0.8998 ------Dr.1943.1.S1_at 3.094038 4.228001 4.750482 4.694223 0.3808 0.072878 0.026488 0.012853 0.0129 abce1 ATP-bindin------nucleotide binding /// ATP binding /// electron carrier activity --- /// ATPase activity /// nucleoside-triphosphatase activity /// iron-sulfur cluster binding Dr.19444.1.S1_at -1.57437 -1.47742 -1.89845 -2.36132 1 1 1 0.564448 0.5644 pou2f1b POU class --- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription specific DNA binding Dr.19446.1.S1_at -2.3363 -2.10064 -2.05364 -1.79511 0.959 0.997 0.999 1 0.959 pcmt l-isoasparty--- protein modification process protein-L-isoaspartate (D-aspartate) O-methyltransferase cytoplasm /// endoplasmic reticulum activity /// methyltransferase activity /// transferase activity

Dr.19450.1.S1 at 3.243936 1.92302 1.122263 1.080671 0.055818 1 1 1 0.0558 zgc:55983 zgc:55983 --- zinc ion transport zinc ion binding /// metal ion binding --- Dr.19463.1.S1 at -1.47614 -1.13688 -1.25527 7.796273 1 1 1 0.021948 0.0219 aspm asp (abnor------binding --- Dr.19465.1.A1 at -1.59048 -2.05563 -1.59608 -2.05896 1 0.999955 1 0.997143 0.9971 ------Dr.19471.1.A1 at 1.945018 2.038652 1.24733 1.451996 0.99934 0.99994 1 1 0.9993 scamp5 Secretory c--- protein transport --- integral to membrane Dr.195.1.S2_at -3.2443 -2.957 -2.22325 -2.92321 0.949 0.978695 0.999955 0.983 0.949 ck2a1 casein kina--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.19501.1.S1_at -1.19374 2.20657 1.890573 1.274392 1 0.9997 1 1 0.9997 wwox WW doma--- metabolic process /// oxidation reduction catalytic activity /// binding /// protein binding /// nucleus /// cytoplasm oxidoreductase activity Dr.19531.1.A1 at 1.456011 1.8158 1.756555 2.133477 1 1 1 0.907435 0.9074 ciao1 cytosolic iro------nucleus Dr.19552.1.S1_at 1.978328 3.369839 3.218408 2.775222 0.999955 0.131193 0.166987 0.311 0.1312 ipo7 importin 7 --- protein import into nucleus, docking /// intracellular protein binding /// protein transporter activity nucleus /// nuclear pore /// cytoplasm transport Dr.19556.2.S1 at -1.52152 -1.80512 -1.31018 -2.49581 1 1 1 0.775815 0.7758 ------Dr.19560.1.S1_at -1.67657 -2.29324 -2.28014 -2.3415 1 0.99556 0.992 0.99321 0.992 insig1 /// LOC100150144 insulin indu--- lipid metabolic process /// steroid metabolic process /// --- endoplasmic reticulum /// endoplasmic cholesterol metabolic process reticulum membrane /// membrane /// integral to membrane Dr.19560.1.S2_at -1.28809 -2.12962 -2.66707 -2.56265 1 0.988 0.256967 0.350868 0.257 insig1 /// LOC100150144 insulin indu--- lipid metabolic process /// steroid metabolic process /// --- endoplasmic reticulum /// endoplasmic cholesterol metabolic process reticulum membrane /// membrane /// integral to membrane Dr.19562.1.S1 at -1.96149 -2.21827 -1.43055 -2.25772 0.9997 0.804302 1 0.423435 0.4234 ------Dr.19568.1.A1 at -1.18223 -1.50103 -2.04079 -1.85683 1 1 0.978177 1 0.9782 ------Dr.19584.1.S1 at -3.24759 -3.39111 -3.71775 -5.46194 0.799398 0.400387 0.082662 0.087 0.0827 CH211-214J8.8 similar to K ------Dr.19588.1.S1_at 1.432594 2.009822 2.448101 3.260486 1 0.999955 0.698853 0.086941 0.0869 zgc:100811 zgc:100811------lysosome /// lysosomal membrane /// endosome /// membrane /// late endosome membrane Dr.19588.2.A1_at 1.269799 2.019075 2.094584 2.453765 1 0.999955 0.999955 0.587538 0.5875 zgc:100811 zgc:100811------lysosome /// lysosomal membrane /// endosome /// membrane /// late endosome membrane Dr.1960.1.A1 at -2.47456 -2.63072 -2.47029 -2.04628 0.409313 0.23143 0.41967 0.962 0.2314 wu:fb55g09 wu:fb55g09------Dr.1961.1.S1_at 5.361223 5.595842 5.614692 4.502063 0.059184 0.032425 0.013537 0.037488 0.0135 rpl7l1 ribosomal p--- translation structural constituent of ribosome /// transcription regulator intracellular /// ribosome /// large ribosomal activity subunit /// ribonucleoprotein complex

Dr.1967.1.A1 at 1.567813 1.51212 1.837661 2.303023 1 1 1 0.832763 0.8328 wu:fb51h06 wu:fb51h06------Dr.19706.1.S1 at -1.69327 -1.74924 -2.21658 -1.67873 1 1 0.841626 1 0.8416 zgc:162081 zgc:162081------membrane /// integral to membrane Dr.19735.1.S1 at -1.60041 -2.34946 -3.40069 -2.35794 1 0.738483 0.048086 0.68158 0.0481 zgc:101639 zgc:101639--- oxidation reduction oxidoreductase activity --- Dr.19790.1.A1 at -1.51933 -1.67207 -1.34261 -2.04755 1 1 1 0.998 0.998 LOC100150924 similar to D--- DNA replication DNA binding /// DNA-directed DNA polymerase activity gamma DNA polymerase complex Dr.198.1.S2_at -1.95175 -2.10726 -2.36206 -2.56535 1 0.998 0.901735 0.671459 0.6715 fst follistatin --- dorsal/ventral pattern formation /// dorsal/ventral pattern --- extracellular region /// signal recognition formation /// negative regulation of signal transduction /// particle, endoplasmic reticulum targeting oocyte differentiation /// determination of dorsal identity

Dr.19848.1.A1 at 3.641808 3.202815 2.528249 2.911092 0.053305 0.192116 0.890246 0.533265 0.0533 zgc:112270 Zgc:11227 ------Dr.1986.1.S1 at 1.415182 2.371009 2.121123 1.618431 1 0.661598 0.997562 1 0.6616 adkb adenosine --- purine ribonucleoside salvage adenosine kinase activity /// kinase activity --- Dr.199.1.A1 at 1.382197 2.372642 2.529675 2.551536 1 0.637384 0.582776 0.320831 0.3208 eaf2 ELL associ------Dr.19902.1.S1_at 1.744116 2.085407 1.452704 1.2639 1 0.993617 1 1 0.9936 ctsl1a cathepsin L--- proteolysis cysteine-type endopeptidase activity /// endopeptidase --- inhibitor activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity Dr.19908.1.S1_s_at -1.56574 -1.8119 -1.78352 -2.25595 1 1 1 0.994 0.994 or103-2 /// or103-2 /// or10 odorant rec--- signal transduction /// G-protein coupled receptor protein rhodopsin-like receptor activity /// signal transducer activity plasma membrane /// membrane /// integral to signaling pathway /// receptor activity /// G-protein coupled receptor activity /// membrane olfactory receptor activity Dr.19915.1.S1_at -3.35203 -4.03299 -3.5602 -3.17775 0.600275 0.247 0.319058 0.523997 0.247 hey1 hairy/enhan--- transcription /// transcription termination /// regulation of DNA binding /// transcription regulator activity nucleus transcription, DNA-dependent /// Notch signaling pathway /// multicellular organismal development /// transcription antitermination /// regulation of transcription

Dr.19923.1.A1 at 1.50566 2.441682 2.77618 3.522813 1 0.673585 0.35 0.15075 0.1507 zgc:153328 zgc:153328--- translation structural constituent of ribosome large ribosomal subunit Dr.19927.1.A1 at -1.45332 -1.58325 -2.23736 -1.83481 1 1 0.982 1 0.982 wu:fb81e04 wu:fb81e04------Dr.19929.1.A1 at 2.831873 5.304614 5.045049 5.053732 0.192943 0.021275 0.02011 0.03951 0.0201 zgc:86751 zgc:86751 ------Dr.1993.1.S1 at 2.383099 2.362669 1.683198 2.228661 0.996927 0.99934 1 0.999 0.9969 cul1a cullin 1a --- ubiquitin-dependent protein catabolic process ubiquitin protein ligase binding cullin-RING ubiquitin ligase complex Dr.19935.1.S1_at 1.23935 2.152469 2.83596 3.607595 1 0.996557 0.378503 0.087559 0.0876 rpl36a ribosomal p--- translation structural constituent of ribosome intracellular /// cytoplasm /// ribosome /// ribonucleoprotein complex Dr.19937.1.S1 at 12.29122 13.9843 14.39121 15.1192 0.017129 0.02 0.014853 0.013741 0.0137 npm1 nucleophos------nucleic acid binding nucleus Dr.19951.1.S1_a_at 2.621778 4.537315 3.876073 4.608279 0.660637 0.375 0.114878 0.069228 0.0692 mybbp1a MYB bindin--- carbohydrate metabolic process /// transcription /// DNA binding /// DNA-directed DNA polymerase activity /// nucleus transcription termination /// regulation of transcription, DNA- hydrolase activity, hydrolyzing O-glycosyl compounds /// dependent /// transcription antitermination binding Dr.19951.1.S1_at 1.724465 2.728564 2.784607 2.869736 1 0.749443 0.208542 0.2573 0.2085 mybbp1a MYB bindin--- carbohydrate metabolic process /// transcription /// DNA binding /// DNA-directed DNA polymerase activity /// nucleus transcription termination /// regulation of transcription, DNA- hydrolase activity, hydrolyzing O-glycosyl compounds /// dependent /// transcription antitermination binding Dr.19967.1.S1_at 1.637024 3.326124 3.686642 4.744142 1 0.535731 0.269949 0.16456 0.1646 nudc nuclear dis--- transport /// lipid transport --- cytoplasm /// endoplasmic reticulum /// Golgi apparatus Dr.19970.1.S1 at -2.37613 -3.1897 -5.58209 -4.54383 0.9997 0.663 0.088373 0.184528 0.0884 im:7139568 /// LOC56200 im:7139568------calcium ion binding --- Dr.19979.1.S1_at -1.85544 -2.10442 -1.5327 -2.59374 1 0.999955 1 0.948881 0.9489 si:dkey-261e22.2 si:dkey-261--- signal transduction /// multicellular organismal development receptor activity intracellular /// membrane /// integral to membrane Dr.20000.1.S1 at -2.13236 -1.76685 -1.46546 -1.1594 0.999 1 1 1 0.999 zgc:153358 zgc:153358--- regulation of transcription, DNA-dependent DNA binding --- Dr.20010.1.S1 at 1.485678 3.520474 3.375961 3.47373 1 0.087496 0.061735 0.106842 0.0617 zgc:85677 zgc:85677 --- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.20010.1.S2 at 1.602027 2.670626 2.435762 2.438412 1 0.036702 0.014367 0.03949 0.0144 zgc:85677 zgc:85677 --- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.20010.10.A1 at 1.658999 2.874208 2.674794 2.758489 1 0.019635 0.0446 0.037604 0.0196 zgc:85677 Zgc:85677 --- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.20010.13.S1 at 1.419987 3.132775 2.933375 3.074668 1 0.204527 0.263166 0.209633 0.2045 zgc:85677 Zgc:85677 --- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.20010.2.A1_at 3.899134 8.94405 11.83536 19.39377 0.030506 0.004711 0.003488 0.003647 0.0035 tuba8l tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.20010.3.S1 at 1.173421 1.674807 1.880437 2.009439 1 1 1 0.996637 0.9966 eif5a eukaryotic t--- translational initiation translation initiation factor activity --- Dr.20010.3.S2 at 2.057267 3.661838 4.249767 4.441517 0.999955 0.021985 0.013905 0.014898 0.0139 eif5a eukaryotic t--- translational initiation translation initiation factor activity --- Dr.20010.4.S1_at -1.1066 1.17881 1.16556 7.049665 1 1 1 0.012074 0.0121 cdca8l cell division --- cell cycle /// mitosis /// cell division --- chromosome, centromeric region /// nucleus /// chromosome Dr.20010.5.A1_at 1.154128 1.739248 2.140232 2.460774 1 1 0.999955 0.807058 0.8071 psmc6 proteasome --- protein catabolic process nucleotide binding /// endopeptidase inhibitor activity /// ATP nucleus /// cytoplasm /// cytosol /// protein binding /// peptidase activity /// hydrolase activity /// complex nucleoside-triphosphatase activity Dr.20010.8.A1_at -1.314 -1.83907 -2.11875 -2.12319 1 1 0.975582 0.923812 0.9238 sox3 SRY-box c--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity nucleus transcription, DNA-dependent /// multicellular organismal development /// transcription antitermination /// positive regulation of transcription factor activity

Dr.20028.1.A1 at -1.44261 -1.74431 -1.29789 -2.19654 1 1 1 0.903724 0.9037 zgc:109902 Zgc:109902--- proteolysis ------Dr.20041.1.S1_at -3.20339 -3.10186 -2.26886 -4.04411 0.728426 0.513 0.94268 0.268874 0.2689 penk proenkepha--- neuropeptide signaling pathway /// negative regulation of --- signal recognition particle, endoplasmic signal transduction reticulum targeting Dr.20052.1.S1_at 1.039411 1.881544 2.026352 2.369811 1 1 1 0.194505 0.1945 ppib peptidylpro--- protein folding peptidyl-prolyl cis-trans isomerase activity /// isomerase --- activity Dr.20055.1.A1 at -2.2634 -4.23244 -7.15109 -5.27089 0.930374 0.1462 0.044672 0.04969 0.0447 ------Dr.20067.2.A1 at 2.823632 3.63693 3.0948 2.863931 0.430856 0.099223 0.197484 0.268745 0.0992 id:ibd1087 id:ibd1087 ------Dr.20070.1.S1_at 1.460988 2.045148 2.359752 2.270498 1 1 0.147438 0.391547 0.1474 eif3c eukaryotic t--- translational initiation translation initiation factor activity eukaryotic translation initiation factor 3 complex Dr.20083.1.A1 at -2.0906 -3.13907 -2.01948 -2.49299 0.975974 0.145502 1 0.511456 0.1455 ccng2 cyclin G2 ------Dr.20085.1.S1_at 1.50765 2.81088 3.234718 3.803372 1 0.366774 0.146819 0.165393 0.1468 eif3ea eukaryotic t--- camera-type eye development /// pigmentation /// embryonic translation initiation factor activity --- viscerocranium morphogenesis Dr.20108.1.S1_a_at 3.299698 5.326031 5.382315 3.911301 0.299471 0.105646 0.079652 0.216575 0.0797 qars glutaminyl-t--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm glutamyl-tRNA aminoacylation /// glutaminyl-tRNA glutamine-tRNA ligase activity /// ATP binding /// ligase aminoacylation activity Dr.20108.2.A1_at 2.204523 3.873492 4.322808 3.652519 0.740127 0.042421 0.018832 0.061212 0.0188 qars glutaminyl-t--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm glutamyl-tRNA aminoacylation /// glutaminyl-tRNA glutamine-tRNA ligase activity /// ATP binding /// ligase aminoacylation activity Dr.20124.1.A1 at 6.111852 10.60064 8.886202 6.144785 0.036021 0.020043 0.01678 0.026388 0.0168 sox4a SRY-box c--- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.20131.1.S1 at -1.51023 -1.39877 -1.80399 2.510616 1 1 1 0.87365 0.8737 crabp2a cellular reti--- transport transporter activity /// binding /// lipid binding --- Dr.20131.2.A1 at 3.61782 6.776793 7.962396 6.227803 0.464753 0.123086 0.015777 0.050789 0.0158 clu /// LOC573883 clusterin (c--- cell death ------Dr.20131.4.S1_at -1.31867 -1.02465 1.068799 14.91328 1 1 1 0.009271 0.0093 plk1 polo-like kin--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity Dr.20131.6.A1 at -1.56396 -1.5441 -1.36391 2.194192 1 1 1 0.877522 0.8775 ------Dr.20131.7.A1_at 2.872532 1.173312 1.647865 2.199272 0.458196 1 1 0.742072 0.4582 zgc:92164 Zgc:92164 --- protein modification process nucleotide binding /// catalytic activity /// ATP binding /// --- manganese ion binding /// metal ion binding Dr.20131.8.S1_at 3.031911 1.175657 2.015334 2.852749 0.163 1 1 0.117153 0.1172 zgc:92164 zgc:92164 --- protein modification process nucleotide binding /// catalytic activity /// ATP binding /// --- manganese ion binding /// metal ion binding Dr.20137.1.S1_at 1.866755 2.7696 2.60158 2.268468 1 0.091 0.740392 0.375585 0.091 MGC174007 /// ngdn hypothetica--- rRNA processing /// regulation of translation --- nucleus /// cytoplasm /// small-subunit processome Dr.20137.2.A1_at 1.664927 2.638063 2.724729 2.395607 1 0.437913 0.351167 0.81864 0.3512 ngdn neuroguidin--- rRNA processing /// regulation of translation --- nucleus /// cytoplasm /// small-subunit processome Dr.20147.1.A1 at -1.20469 2.072479 2.364814 22.87528 1 0.99934 0.981615 0.021824 0.0218 anln-like /// LOC562517 /// anillin, actin ------Dr.20153.1.A1 at 2.406207 3.890275 4.247436 5.439904 0.922 0.352232 0.475172 0.157842 0.1578 myl9l myosin, ligh------calcium ion binding --- Dr.20153.1.S1 a at 1.97173 2.921261 3.20829 4.190758 0.991876 0.179236 0.443104 0.095177 0.0952 myl9l myosin, ligh------calcium ion binding --- Dr.20153.2.S1 at 1.931763 2.131667 2.214893 2.284111 1 0.910449 0.743 0.612 0.612 myl9l myosin, ligh------calcium ion binding --- Dr.20156.1.S1_at 1.920673 3.386594 3.739957 4.539212 1 0.211546 0.125238 0.091259 0.0913 psma5 proteasome --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase cytosol /// proteasome core complex /// protein activity /// endopeptidase inhibitor activity /// peptidase complex activity /// hydrolase activity Dr.20160.1.S1 at -1.88541 -2.10508 -2.38264 -2.5337 1 0.99994 0.82222 0.624358 0.6244 zgc:73142 zgc:73142 --- dopamine receptor signaling pathway dopamine receptor binding integral to membrane Dr.20167.2.S1_a_at 1.281352 2.258382 2.828758 3.283685 1 0.607856 0.079749 0.013089 0.0131 rps24 ribosomal p--- translation nucleotide binding /// structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.20170.1.S1 at 1.658074 4.411423 4.257993 4.110446 1 0.057849 0.067973 0.056498 0.0565 dad1 defender ag------Dr.20181.1.S1 at 1.450946 1.450507 1.763287 3.094007 1 1 1 0.122982 0.123 anp32e acidic (leuc------protein binding nucleus /// cytoplasm Dr.20189.1.A1 at 2.276556 1.486291 1.201115 1.690668 0.69544 1 1 1 0.6954 wu:fb52d12 wu:fb52d12------Dr.20190.1.S1_at 1.001007 1.036217 1.956587 3.761708 1 1 1 0.102 0.102 zgc:85772 zgc:85772 ------nucleotide binding /// ATP binding /// nucleoside- --- triphosphatase activity Dr.20191.1.S1 at 1.413106 2.105733 2.279549 2.587072 1 0.997322 0.995911 0.833 0.833 seh1l SEH1-like ------Dr.20192.1.A1_at 1.642351 2.137395 1.941818 2.062279 1 0.993 1 0.999955 0.993 usp5 ubiquitin sp--- ubiquitin-dependent protein catabolic process ubiquitin thiolesterase activity /// endopeptidase inhibitor --- activity /// calcium ion binding /// peptidase activity /// cysteine-type peptidase activity /// zinc ion binding /// hydrolase activity Dr.20194.1.S1 at 1.447486 1.916791 1.986448 2.293721 1 1 1 0.793411 0.7934 zgc:55311 zgc:55311 --- nucleocytoplasmic transport /// RNA transport --- nuclear pore Dr.20197.1.A1 at -1.70055 -1.66819 -2.44464 -2.33681 1 1 0.142633 0.229481 0.1426 wu:fi32b04 wu:fi32b04 ------Dr.20214.1.A1_at -2.64494 -1.96168 -1.64143 -2.02095 0.871889 1 1 0.999955 0.8719 tuba8l3 tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.2022.1.A1_at -1.70586 3.007373 2.971327 2.729331 1 0.354925 0.509541 0.608183 0.3549 arg2 arginase, ty------hydrolase activity /// hydrolase activity, acting on carbon- --- nitrogen (but not peptide) bonds, in linear amidines /// manganese ion binding /// metal ion binding

Dr.20238.1.A1 at -1.44746 -1.73031 -1.35846 -2.23032 1 1 1 0.906 0.906 ------Dr.20267.1.A1 at 1.514591 2.064715 2.099432 2.702769 1 0.999955 0.999955 0.757581 0.7576 zgc:172056 zgc:172056------structural constituent of nuclear pore nuclear pore Dr.20276.1.A1 at -2.02635 -2.63495 -2.35552 -2.95643 0.991 0.387934 0.933 0.231369 0.2314 wu:fb81h03 wu:fb81h03------Dr.20331.1.A1 at 1.231159 2.01582 1.793434 1.497968 1 0.995911 1 1 0.9959 hm13 histocompa--- regulation of neuron apoptosis aspartic-type endopeptidase activity integral to membrane Dr.20335.1.A1 at -2.48712 -3.0675 -3.23897 -3.04991 0.671171 0.254235 0.156662 0.261651 0.1567 ------Dr.20339.1.S1 at 1.07484 -1.38552 -1.40866 -2.08061 1 1 1 0.987827 0.9878 copeb core promo------nucleic acid binding /// zinc ion binding intracellular Dr.20340.1.A1_at 1.639311 3.557369 4.34598 7.356332 1 0.036768 0.012176 0.007389 0.0074 zgc:77235 zgc:77235 --- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.20347.1.S1 at 1.264486 1.974496 2.131377 2.834907 1 1 0.999917 0.204186 0.2042 psmd12 proteasome ------cytosol /// protein complex Dr.20386.1.S1_at -2.01824 -1.81105 -1.51773 -1.10953 0.9997 1 1 1 0.9997 CH73-21G5.4 /// her4.2 /// hairy-relate--- somite specification /// transcription /// transcription DNA binding /// double-stranded DNA binding /// nucleus termination /// regulation of transcription, DNA-dependent /// transcription regulator activity Notch signaling pathway /// anterior/posterior pattern formation /// transcription antitermination /// regulation of transcription Dr.20386.2.S1 a at 1.151143 2.044153 1.975875 1.806896 1 0.961829 1 1 0.9618 zgc:110087 zgc:110087--- translation /// translational initiation RNA binding /// translation initiation factor activity --- Dr.20386.3.S1 at 1.4771 2.328529 2.600564 3.043538 1 0.776236 0.470887 0.163802 0.1638 zgc:110087 zgc:110087--- translation /// translational initiation RNA binding /// translation initiation factor activity --- Dr.20389.1.A1 at -1.75287 -2.23632 -1.62729 -2.62361 1 0.961627 1 0.457737 0.4577 ------Dr.20391.1.A1 at -1.39422 -1.77907 -2.08695 -2.19812 1 1 0.999 0.941454 0.9415 LOC563577 similar to n------Dr.20398.1.A1 a at -2.01361 -2.43339 -1.86153 -2.45609 0.999917 0.717057 1 0.60538 0.6054 acsl1 acyl-CoA s--- metabolic process catalytic activity --- Dr.20398.1.A1 at -1.80851 -1.92905 -1.90776 -2.16227 1 1 1 0.995 0.995 acsl1 acyl-CoA s--- metabolic process catalytic activity --- Dr.20398.1.A1 x at -1.89623 -1.91307 -1.70675 -2.42784 1 1 1 0.495662 0.4957 acsl1 acyl-CoA s--- metabolic process catalytic activity --- Dr.20398.2.A1 at -1.38249 -1.64814 -1.7836 -2.04497 1 1 1 0.99934 0.9993 acsl1 acyl-CoA s--- metabolic process catalytic activity --- Dr.20414.1.A1 s at 1.903015 2.434011 2.355795 1.945097 1 0.264858 0.229611 1 0.2296 zgc:110436 zgc:110436------Dr.20417.1.S1 at -1.29991 1.54953 2.157433 1.927081 1 1 0.995 1 0.995 zgc:101858 zgc:101858--- metabolic process /// oxidation reduction catalytic activity /// binding /// oxidoreductase activity --- Dr.20419.2.A1 at -1.48003 -1.83873 -1.44065 -2.11557 1 1 1 0.942 0.942 ------Dr.20429.2.S1 a at -2.11583 -1.6084 -1.09311 5.634842 0.99994 1 1 0.114 0.114 dlgap5 discs, large --- cell-cell signaling ------Dr.20450.1.A1 at -1.61073 -1.73695 -1.70346 -2.05211 1 1 1 0.998 0.998 ------Dr.20488.1.S1_at -1.36077 -1.37339 -2.02286 -1.94255 1 1 0.997562 1 0.9976 guanine nu--- signal transduction /// G-protein coupled receptor protein nucleotide binding /// signal transducer activity /// GTP --- signaling pathway binding /// guanyl nucleotide binding Dr.20507.1.A1 at -1.20381 -1.10475 -1.00902 2.232326 1 1 1 0.78838 0.7884 zgc:112184 zgc:112184--- DNA repair DNA binding --- Dr.2051.1.S1_at 1.083172 -1.3657 -1.52412 -4.57533 1 1 1 0.031179 0.0312 hmgcs1 3-hydroxy-3--- metabolic process /// isoprenoid biosynthetic process catalytic activity /// hydroxymethylglutaryl-CoA synthase --- activity Dr.20517.1.S1 at -1.23906 -1.77161 -2.71744 -2.05503 1 1 0.483 0.996 0.483 ndrg3a N-myc dow------Dr.2052.1.S1_at 1.841445 2.152305 1.640947 1.591346 1 0.65029 1 1 0.6503 tp53 tumor prote--- DNA damage checkpoint /// response to tumor cell /// DNA binding /// transcription factor activity /// protein binding nucleus /// cytoplasm transcription /// transcription termination /// regulation of /// zinc ion binding /// transcription activator activity /// transcription, DNA-dependent /// zinc ion transport /// transcription regulator activity /// metal ion binding apoptosis /// induction of apoptosis /// DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator /// cell cycle /// response to UV /// RNA-protein covalent cross-linking /// negative regulation of cell growth /// transcription antitermination /// DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis /// positive regulation of apoptosis /// positive regulation of apoptosis /// positive regulation of caspase activity /// positive regulation of neuron apoptosis /// regulation of transcription /// negative regulation of cell cycle /// negative regulation of cell cycle /// positive regulation of transcription, DNA-dependent /// response to methylmercury

Dr.20521.1.A1 at -1.27604 -2.05875 -2.6036 -2.26954 1 0.996244 0.275886 0.703729 0.2759 ------Dr.20523.1.S1_at 1.373837 1.934168 2.000936 1.851231 1 1 0.99994 1 0.9999 zgc:92790 zgc:92790 --- transcription, DNA-dependent /// regulation of transcription DNA binding /// DNA-directed RNA polymerase activity RNA polymerase complex

Dr.20524.1.A1_at -1.35804 -1.89944 -1.71365 -2.09633 1 1 1 0.997562 0.9976 zgc:136764 zgc:136764--- two-component signal transduction system (phosphorelay) two-component sensor activity /// DNA binding /// signal nucleus /// transcription /// transcription termination /// regulation of transducer activity /// transcription regulator activity transcription, DNA-dependent /// signal transduction /// transcription antitermination /// regulation of transcription

Dr.20525.1.A1 a at 3.156636 2.314501 1.220868 -1.11205 0.071717 0.847274 1 1 0.0717 zgc:77868 zgc:77868 ------zinc ion binding intracellular /// cytoplasm Dr.20538.1.A1_at 2.268466 2.315271 2.661776 2.825413 0.895 0.874217 0.870892 0.434498 0.4345 LOC554736 hypothetica--- amino acid biosynthetic process /// methionine biosynthetic protein binding /// nickel ion binding /// oxidoreductase nucleus /// cytoplasm /// plasma membrane process /// methionine salvage /// methionine salvage /// activity /// oxidoreductase activity /// oxidoreductase activity, oxidation reduction acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// metal ion binding /// dioxygenase activity Dr.20539.1.A1 at -2.34272 -2.90223 -3.79439 -3.59619 0.472909 0.22542 0.058589 0.02172 0.0217 wu:fc20g02 wu:fc20g02------Dr.20545.1.S1 at -1.96553 -2.08774 -2.10133 -1.68952 1 0.964513 0.894192 1 0.8942 ------Dr.20555.1.S2_s_at 2.763139 1.603045 1.371655 1.267138 0.816 1 1 1 0.816 anx /// anxa5 annexin /// --- calcium ion transport /// negative regulation of coagulation calcium channel activity /// calcium ion binding /// calcium- cytoplasm dependent phospholipid binding /// calcium channel inhibitor activity Dr.20576.2.S1_a_at 1.326437 1.592729 1.639472 2.160589 1 1 1 0.945 0.945 atp5a1 /// gcdh ATP syntha--- ATP biosynthetic process /// transport /// ion transport /// nucleotide binding /// acyl-CoA dehydrogenase activity /// proton-transporting two-sector ATPase metabolic process /// ATP synthesis coupled proton ATP binding /// electron carrier activity /// hydrogen ion complex /// proton-transporting ATP synthase transport /// proton transport /// ATP metabolic process transmembrane transporter activity /// oxidoreductase activity complex, catalytic core F(1) /// oxidoreductase activity, acting on the CH-CH group of donors /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances /// metal ion binding /// hydrogen ion transporting ATP synthase activity, rotational mechanism /// hydrogen ion transporting ATPase activity, rotational mechanism /// FAD binding

Dr.20582.1.S1_at -2.6086 -3.47197 -3.73113 -2.86562 0.763161 0.318303 0.317886 0.575954 0.3179 rbpms2 /// zorba RNA bindin--- mRNA processing /// regulation of translation nucleotide binding /// nucleic acid binding /// RNA binding cytoplasm

Dr.20582.1.S2_at -2.23423 -2.83925 -2.88375 -2.65324 0.52781 0.087384 0.058644 0.253 0.0586 rbpms2 /// zorba RNA bindin--- mRNA processing /// regulation of translation nucleotide binding /// nucleic acid binding /// RNA binding cytoplasm

Dr.20594.1.S1_at -3.01524 -2.62531 -2.96882 -2.7471 0.972 0.980565 0.934 0.958399 0.934 zgc:101761 zgc:101761--- protein amino acid ADP-ribosylation /// signal transduction nucleotide binding /// signal transducer activity /// GTP --- /// G-protein coupled receptor protein signaling pathway binding /// guanyl nucleotide binding

Dr.20597.1.S1 at -1.62822 -1.75374 -1.34287 -2.16575 1 1 1 0.982 0.982 zgc:193505 zgc:193505------Dr.20603.1.S1 at -1.66929 -1.6516 -1.25398 -2.03161 1 1 1 0.999 0.999 CH211-112F11.1 /// inadl novel prote------protein binding /// sugar binding --- Dr.2062.1.S1_at -1.02673 -1.10479 -1.05318 2.356791 1 1 1 0.521227 0.5212 vrk1 vaccinia rel--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein nucleus serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.20627.1.S1_at -1.10507 1.796536 2.09944 2.301634 1 1 0.999955 0.849747 0.8497 psmb5 proteasome --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome activity /// endopeptidase inhibitor activity /// peptidase core complex /// protein complex activity /// hydrolase activity Dr.20632.1.A1 at 2.095779 2.013473 1.582147 2.144923 0.996 1 1 0.992263 0.9923 ------Dr.20640.1.A1 at -1.18433 -1.8553 -2.12515 -2.19214 1 1 0.962 0.858 0.858 LOC799443 similar to b------Dr.2066.1.A1 at 1.179384 1.11719 1.172105 2.43579 1 1 1 0.651496 0.6515 zgc:136346 zgc:136346------Dr.20660.1.A1 at -1.61004 -1.51889 -1.3162 -2.05697 1 1 1 0.9997 0.9997 pdc1 phosducin ------Dr.20668.1.A1_at -1.48281 -1.80285 -2.33932 -1.86262 1 1 0.728727 1 0.7287 zgc:112986 zgc:112986------serine-type endopeptidase activity /// endopeptidase inhibitor mitochondrion /// mitochondrial inner activity /// peptidase activity /// hydrolase activity membrane /// membrane /// integral to membrane Dr.2067.1.A1 at -1.80897 -2.13038 -1.93864 -1.82845 1 0.999917 1 1 0.9999 zgc:158431 zgc:158431------Dr.20687.1.A1 at 1.040195 1.470932 2.681311 2.617558 1 1 0.502094 0.455032 0.455 rb1 retinoblasto------Dr.20690.1.S1 at 1.397163 2.026457 2.553327 3.044112 1 0.999955 0.775735 0.399437 0.3994 ssrp1a structure s--- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.2071.1.S1_at 2.578448 3.117804 2.963308 1.798563 0.537931 0.111616 0.143782 1 0.1116 zgc:56011 zgc:56011 --- metabolic process catalytic activity /// hydrolase activity /// phosphatase activity ---

Dr.20716.2.A1 at -1.22395 -1.48769 -1.88873 -2.1202 1 1 1 0.868588 0.8686 zgc:171719 zgc:171719------Dr.20763.1.S1 at -1.95759 -2.15299 -2.27648 -2.70473 1 0.999 0.995 0.915559 0.9156 zgc:101738 zgc:101738--- proteolysis /// signal transduction aspartic-type endopeptidase activity /// protein binding --- Dr.20789.1.A1_at 1.381596 2.533594 2.290128 2.366516 1 0.245 0.907435 0.475 0.245 erbb2 v-erb-b2 er--- protein folding /// protein amino acid phosphorylation /// nucleotide binding /// peptidyl-prolyl cis-trans isomerase membrane transmembrane receptor protein tyrosine kinase signaling activity /// protein kinase activity /// protein tyrosine kinase pathway /// axonal fasciculation /// Schwann cell activity /// transmembrane receptor protein tyrosine kinase differentiation /// Schwann cell development /// activity /// ATP binding /// kinase activity /// transferase ensheathment of non-myelinated axons /// myelination /// activity /// isomerase activity myelination of anterior lateral line nerve axons /// posterior lateral line neuromast development /// myelination of posterior lateral line nerve axons Dr.20794.1.A1 at -8.36373 -9.22947 -8.18245 -7.76383 0.102358 0.091954 0.115426 0.117811 0.092 ------Dr.208.1.S1_at 1.588133 2.450932 2.504851 1.832031 1 0.968574 0.862 1 0.862 slc11a2 solute carri--- transport /// embryonic hemopoiesis /// hemoglobin transporter activity /// iron ion transmembrane transporter membrane biosynthetic process activity Dr.20805.1.S1_at 4.420045 4.729171 4.626298 4.976232 0.116234 0.023756 0.017447 0.017588 0.0174 bzw1b basic leucin--- transcription /// transcription termination /// regulation of binding --- transcription, DNA-dependent /// transcription antitermination Dr.2083.1.S1_at 1.966886 3.970862 5.073362 6.05581 0.996 0.034 0.023545 0.028033 0.0235 ruvbl1 RuvB-like 1 --- DNA recombination /// transcription /// transcription nucleotide binding /// DNA helicase activity /// helicase nucleus termination /// regulation of transcription, DNA-dependent /// activity /// ATP binding /// hydrolase activity /// nucleoside- transcription antitermination /// positive regulation of triphosphatase activity transcription Dr.20839.1.A1 at -1.68603 -2.04993 -1.54057 -2.5284 1 1 1 0.66464 0.6646 ------Dr.20839.1.A1 x at -1.57947 -1.80963 -1.35613 -2.30757 1 1 1 0.955495 0.9555 ------Dr.20841.1.S1 at -2.10517 -2.79101 -3.1011 -1.92195 0.997562 0.643836 0.449506 1 0.4495 zgc:174637 zgc:174637------arylesterase activity --- Dr.20848.1.A1 at 2.469831 2.50927 2.548162 1.999501 0.854 0.867 0.903 1 0.854 zgc:113369 zgc:113369------RNA binding /// endoribonuclease activity --- Dr.20856.1.S1 at -1.70218 -2.35844 -1.43944 -3.20039 1 0.671377 1 0.407464 0.4075 ------Dr.20872.1.S1_at -1.09643 1.403232 1.916973 2.564904 1 1 1 0.231181 0.2312 psma6a proteasome --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase cytosol /// proteasome core complex /// protein activity /// endopeptidase inhibitor activity /// peptidase complex activity /// hydrolase activity Dr.20879.1.A1_s_at 1.047071 2.198288 2.436359 2.857315 1 0.980331 0.632787 0.356394 0.3564 psmd1 proteasome --- regulation of protein catabolic process binding /// enzyme regulator activity proteasome complex /// cytosol /// protein complex Dr.20911.1.S1_at -1.0747 1.065632 1.775057 2.463613 1 1 1 0.619 0.619 eya1 eyes absen--- multicellular organismal development /// metabolic process catalytic activity --- /// adenohypophysis development /// adenohypophysis development /// inner ear morphogenesis

Dr.20916.1.A1_at 4.204379 5.435938 5.30026 4.510064 0.023217 0.014808 0.010438 0.013 0.0104 LOC100002989 /// LOC10similar to N --- regulation of transcription, DNA-dependent /// multicellular DNA binding /// transcription factor activity /// zinc ion nucleus organismal development /// regulation of transcription binding /// sequence-specific DNA binding /// metal ion binding Dr.20919.1.S1_at -2.38845 -1.80707 -1.34536 1.4411 0.996964 1 1 1 0.997 sephs1 selenophos------nucleotide binding /// catalytic activity /// selenide, water --- dikinase activity /// ATP binding /// selenium binding /// kinase activity /// transferase activity Dr.20935.1.S1_at -1.78634 -1.79292 -2.00456 -1.47642 1 1 0.99161 1 0.9916 mylip myosin reg--- zinc ion transport /// gastrulation binding /// protein binding /// zinc ion binding /// ligase activity cytoplasm /// cytoplasm /// cytoskeleton /// metal ion binding Dr.20938.1.S1_at -1.27674 -1.61829 -2.06825 -1.8181 1 1 0.991488 1 0.9915 sod1 superoxide --- superoxide metabolic process /// copper ion transport /// superoxide dismutase activity /// superoxide dismutase cytoplasm zinc ion transport /// response to metal ion /// response to activity /// copper ion transmembrane transporter activity /// methylmercury /// oxidation reduction copper ion binding /// zinc ion binding /// antioxidant activity /// oxidoreductase activity /// metal ion binding

Dr.20947.2.A1 a at 1.596835 3.096321 4.779326 8.480591 1 0.235227 0.072152 0.068 0.068 nasp nuclear aut------binding --- Dr.20954.1.S1 at 2.800567 2.943865 2.756387 3.042662 0.816 0.87365 0.836683 0.628 0.628 klc1 kinesin ligh ------microtubule motor activity /// binding kinesin complex Dr.20958.1.S1_at -2.21669 -1.43353 1.846468 2.721332 0.998 1 1 0.373941 0.3739 dld deltaD --- somitogenesis /// somitogenesis /// calcium ion transport /// calcium channel activity /// calcium ion binding /// protein cytoplasm /// signal recognition particle, cell communication /// Notch signaling pathway /// binding /// calcium channel inhibitor activity /// PDZ domain endoplasmic reticulum targeting /// plasma multicellular organismal development /// determination of binding /// PDZ domain binding /// PDZ domain binding membrane /// membrane /// membrane /// left/right symmetry /// nervous system development /// integral to membrane /// perinuclear region of anterior/posterior pattern formation /// negative regulation of cytoplasm signal transduction /// somatic motor neuron differentiation /// cell differentiation /// lateral inhibition /// gut morphogenesis Dr.20961.1.S1_at -1.83638 -2.17346 -2.53516 -2.54958 1 0.99994 0.804674 0.817286 0.8047 cpla2 cytosolic ph--- proteolysis /// calcium ion transport /// metabolic process /// phospholipase activity /// lysophospholipase activity /// cytoplasm /// cytoplasmic vesicle phospholipid catabolic process /// lipid catabolic process phospholipase A2 activity /// calcium channel activity /// calcium ion binding /// hydrolase activity /// calcium channel inhibitor activity Dr.20979.1.S1_at -1.36055 -1.26263 -1.64955 -2.30403 1 1 1 0.718548 0.7185 fgf8b fibroblast g--- multicellular organismal development /// pattern specification fibroblast growth factor receptor binding /// growth factor extracellular region /// signal recognition process /// nervous system development /// cell proliferation activity particle, endoplasmic reticulum targeting /// fibroblast growth factor receptor signaling pathway /// negative regulation of signal transduction /// cell differentiation /// midbrain-hindbrain boundary development

Dr.21009.1.S1_at -1.80414 -1.97607 -1.48654 -2.05364 1 1 1 0.993617 0.9936 nos1 nitric oxide --- nitric oxide biosynthetic process nitric-oxide synthase activity /// iron ion binding /// protein --- binding /// calmodulin binding /// electron carrier activity /// FMN binding /// oxidoreductase activity /// heme binding /// FAD binding /// NADP binding Dr.21041.1.S1_at -2.04425 -3.37351 -3.6862 -3.51623 1 0.275147 0.187756 0.329 0.1878 zgc:55318 zgc:55318 --- GPI anchor biosynthetic process /// cell adhesion /// protein binding signal recognition particle, endoplasmic negative regulation of signal transduction reticulum targeting /// plasma membrane /// membrane /// anchored to membrane Dr.21051.1.S1 at -1.24217 1.441378 3.035706 7.658025 1 1 0.165335 0.017581 0.0176 zgc:56310 zgc:56310 ------Dr.21060.1.S1_at -1.51903 -2.24964 -1.33761 -2.35724 1 0.977272 1 0.958708 0.9587 scn1a sodium cha--- transport /// ion transport /// potassium ion transport /// ion channel activity /// voltage-gated ion channel activity /// voltage-gated sodium channel complex /// sodium ion transport /// calcium ion transport voltage-gated calcium channel activity /// voltage-gated voltage-gated sodium channel complex /// sodium channel activity /// voltage-gated sodium channel voltage-gated calcium channel complex /// activity /// voltage-gated potassium channel activity /// voltage-gated potassium channel complex /// sodium channel activity membrane /// integral to membrane Dr.21061.1.S1_at -1.69781 -1.76225 -1.4232 -2.12623 1 1 1 0.996244 0.9962 gnsb glucosamin--- metabolic process /// glycosaminoglycan metabolic process catalytic activity /// N-acetylglucosamine-6-sulfatase activity --- /// sulfuric ester hydrolase activity Dr.21080.1.A1 at -2.40844 -1.47731 -3.83274 -2.42212 0.991553 1 0.539 0.975461 0.539 wu:fb18g01 wu:fb18g01------Dr.2110.1.A1_at -1.58233 -2.03704 -1.39905 -1.00288 1 0.972632 1 1 0.9726 zgc:100912 zgc:100912--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.21131.1.A1 at 1.321615 2.027929 2.313385 2.100205 1 0.995 0.926319 0.989 0.9263 wu:fb78f01 wu:fb78f01 ------Dr.21165.1.S1 at 2.246763 2.41649 2.128131 1.70162 0.99556 0.99 0.999955 1 0.99 wu:fb82f09 wu:fb82f09 ------Dr.2118.1.S1_at 1.495869 2.067155 1.343959 1.296405 1 0.998 1 1 0.998 ptpn2l protein tyro--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// receptor activity /// --- hydrolase activity /// phosphatase activity Dr.21182.1.A1 at -2.6461 -5.42532 -5.56494 -4.12927 0.141825 0.085682 0.004867 0.018824 0.0049 ------Dr.21193.1.A1 at -1.72093 -2.07508 -1.65138 -1.77577 1 0.991876 1 1 0.9919 LOC557376 similar to fi------Dr.21224.1.S1 at 2.574255 1.127602 -1.08021 1.261053 0.702976 1 1 1 0.703 wu:fb94e12 wu:fb94e12------Dr.2124.1.A1 at -1.27479 -2.22392 -2.29976 -3.00975 1 0.974 0.938432 0.492227 0.4922 si:dkeyp-84f11.5 si:dkeyp-84--- cell wall catabolic process ------Dr.21244.1.S1_at -1.39524 1.994861 2.5257 2.859401 1 0.996927 0.739485 0.390356 0.3904 ucp2 uncoupling --- transport /// mitochondrial transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.21282.1.A1 at 1.202105 2.326875 2.459859 2.062869 1 0.996244 0.996 0.99994 0.996 wu:fb98h04 wu:fb98h04------Dr.2130.1.A1 at -1.17902 -1.0083 1.421482 4.119639 1 1 1 0.153809 0.1538 whsc1 Wolf-Hirsc------protein binding /// zinc ion binding nucleus Dr.21368.1.A1_at -1.76661 -2.15329 -1.45433 -1.71061 1 0.954634 1 1 0.9546 inppl1 /// LOC572691 inositol poly--- immune response /// cell adhesion /// metabolic process actin binding /// inositol or phosphatidylinositol phosphatase cytoplasm /// cytoskeleton /// membrane activity /// protein binding /// oxidoreductase activity /// hydrolase activity /// phosphatase activity

Dr.21403.1.S1 at 1.905165 2.385547 2.473727 1.8948 1 0.99 0.749 1 0.749 zgc:110281 zgc:110281------Dr.21420.1.A1 at -1.69076 -1.81671 -1.54335 -2.37987 1 1 1 0.408139 0.4081 ------Dr.21443.1.A1 at 2.337027 1.05172 -1.08145 -1.20063 0.869443 1 1 1 0.8694 wu:fc13b01 wu:fc13b01------Dr.21450.2.A1 at 2.999939 4.828782 4.574909 3.936621 0.118379 0.073495 0.072718 0.104165 0.0727 ------Dr.21450.2.A1 x at 3.205373 4.68393 4.499917 3.605751 0.076869 0.12522 0.051543 0.03123 0.0312 ------Dr.21482.1.A1 at -2.18781 -1.93757 -1.80986 -1.79754 0.99556 1 1 1 0.9956 wu:fc37g05 wu:fc37g05------Dr.21502.1.A1 at 2.204861 3.121979 3.029925 3.766266 0.938303 0.223363 0.328781 0.143632 0.1436 ------Dr.21519.1.A1 at -1.05843 -1.23056 -1.2645 2.244151 1 1 1 0.996927 0.9969 ------Dr.21543.1.A1 at 1.8991 3.025168 3.704603 5.315072 0.999955 0.045744 0.363176 0.041351 0.0414 wu:fc41f11 wu:fc41f11 ------Dr.2155.2.S1_at 1.51283 2.298296 2.337544 2.462858 1 0.826 0.595509 0.48268 0.4827 ppa1 pyrophosph--- phosphate metabolic process magnesium ion binding /// inorganic diphosphatase activity cytoplasm

Dr.21567.1.A1 at -1.60389 -1.69227 -1.35065 -2.11853 1 1 1 0.971687 0.9717 wu:fc29c12 wu:fc29c12------Dr.21573.1.A1 at 1.214514 1.626984 1.531618 2.148398 1 1 1 0.996674 0.9967 ------Dr.21603.1.A1 at -1.53194 -2.17556 -3.91656 -3.87463 1 0.972478 0.098422 0.071899 0.0719 wu:fc25d07 wu:fc25d07------Dr.21609.1.A1 at -2.06121 -2.08066 -1.77651 -2.00711 0.99934 0.999325 1 0.999955 0.9993 ------Dr.21646.1.A1 at 2.121951 1.737588 -1.03855 -1.29459 0.980893 1 1 1 0.9809 wu:fc33b10 wu:fc33b10------Dr.21660.1.A1 at 1.295223 1.806586 1.82722 2.005885 1 1 1 0.993617 0.9936 ------Dr.21666.1.A1 at 1.655704 2.33647 1.79935 1.521789 1 0.61423 1 1 0.6142 wu:fc34g05 wu:fc34g05------Dr.21667.1.A1 at 1.624076 2.206864 1.472182 1.417817 1 0.977272 1 1 0.9773 ------Dr.21670.1.A1 at 2.069149 2.075304 1.460988 2.047057 0.996244 0.99934 1 0.999955 0.9962 ------Dr.2168.1.A1 at 2.86867 2.443359 1.724779 2.567608 0.3827 0.839237 1 0.975974 0.3827 wu:fb09b12 wu:fb09b12------Dr.217.1.A1 at -1.89753 -2.12013 -1.71147 -2.11012 1 0.994863 1 0.999955 0.9949 ------Dr.21711.1.A1 at 1.371881 1.789107 2.110782 2.051224 1 1 0.981 1 0.981 LOC100003772 /// LOC10hypothetica ------Dr.21722.1.A1 at 4.287679 5.958364 3.758751 3.494754 0.116092 0.043303 0.280549 0.278322 0.0433 zgc:158284 zgc:158284------membrane /// integral to membrane Dr.21734.1.A1 at 1.911876 3.842571 6.996903 5.138811 0.999955 0.051795 0.017896 0.025299 0.0179 LOC558119 similar to N ------Dr.21742.1.A1 at -1.94583 -1.52324 -2.33469 -2.07259 1 1 0.220744 0.987421 0.2207 wu:fc51a12 wu:fc51a12------Dr.21766.1.A1 at -1.49102 -1.75824 -1.48099 -2.09542 1 1 1 0.973527 0.9735 ------Dr.21781.1.A1 at 2.684219 3.429311 2.714905 1.930525 0.651063 0.281422 0.728767 1 0.2814 wu:fc55f06 wu:fc55f06 ------Dr.21783.1.S1 at 4.279952 5.496372 5.550814 3.95717 0.131898 0.070741 0.068549 0.177913 0.0685 ------Dr.21798.1.A1 at -1.54603 -2.10503 -1.78932 -2.44057 1 0.986338 1 0.858698 0.8587 wu:fc46a02 wu:fc46a02------Dr.218.1.A1_at 2.154618 3.199082 2.999425 2.795358 0.989 0.10887 0.15 0.054893 0.0549 farsl phenylalani--- translation /// phenylalanyl-tRNA aminoacylation nucleotide binding /// RNA binding /// phenylalanine-tRNA cytoplasm ligase activity /// ATP binding Dr.21811.1.S1 at 2.045847 6.594292 8.092942 4.808263 0.99934 0.115362 0.070313 0.209 0.0703 ------Dr.21814.1.S1 at 1.039028 2.584298 3.223733 3.542405 1 0.787796 0.305557 0.283655 0.2837 zgc:136864 zgc:136864------Dr.21814.1.S1 s at 1.431301 2.339147 3.005263 3.74159 1 0.993617 0.512569 0.219943 0.2199 zgc:136864 zgc:136864------Dr.21816.1.A1 at 1.635893 2.3595 3.025079 3.535044 1 0.455252 0.154616 0.063611 0.0636 wu:fc46a11 wu:fc46a11------Dr.21848.1.A1 at 1.736331 2.825313 2.974538 3.020064 1 0.268344 0.291312 0.199 0.199 ------Dr.21849.1.A1 at -1.69172 -1.97351 -1.47161 -2.24966 1 1 1 0.917592 0.9176 LOC797211 similar to U ------Dr.2187.1.S1_at 1.586594 2.528362 2.179355 2.193491 1 0.065441 0.959 0.273748 0.0654 slc35b4 solute carri--- transport /// carbohydrate transport sugar:hydrogen symporter activity Golgi membrane /// Golgi apparatus /// membrane /// integral to membrane Dr.21875.1.A1 at 1.601681 2.250644 2.644929 2.023529 1 0.925825 0.37638 0.999955 0.3764 ------Dr.21879.1.A1 at -1.50838 -2.17653 -2.67421 -1.86918 1 0.977266 0.449713 1 0.4497 wu:fc76e09 wu:fc76e09------Dr.21889.1.A1 at 1.822394 2.009921 1.307409 1.871198 1 0.998 1 0.999955 0.998 wu:fc67a12 wu:fc67a12------Dr.21890.1.A1 at -2.17681 -2.19487 -1.87283 -2.63626 0.99934 0.990497 1 0.815 0.815 ------Dr.21897.1.A1 at 1.256552 2.240472 2.583751 3.344143 1 0.991278 0.302247 0.149091 0.1491 wu:fc79b06 wu:fc79b06------Dr.21902.1.A1 at -1.57621 -1.62049 -1.39076 -2.03515 1 1 1 0.9997 0.9997 ------Dr.21921.1.A1_at 2.361963 1.123941 -1.22491 -1.27819 0.648621 1 1 1 0.6486 zgc:103654 zgc:103654--- metabolic process /// enterobactin biosynthetic process /// catalytic activity /// binding /// 2,3-dihydro-2,3- --- oxidation reduction dihydroxybenzoate dehydrogenase activity /// oxidoreductase activity Dr.21927.1.A1 at -1.77186 -2.04843 -1.47661 -2.59437 1 0.999955 1 0.837397 0.8374 wu:fc83f07 wu:fc83f07 ------Dr.21944.1.A1 at -1.28535 -1.30614 -1.64914 -2.04236 1 1 1 0.996 0.996 wu:fc84h02 wu:fc84h02------Dr.21959.1.A1 at -1.8834 -1.79389 -1.50726 -2.29221 1 1 1 0.93 0.93 ------Dr.22005.1.A1 at -1.79922 -2.05956 -1.56704 -2.49038 1 0.999917 1 0.496 0.496 wu:fd02e05 wu:fd02e05------Dr.22017.1.A1 at -1.03192 1.288318 1.264835 2.300438 1 1 1 0.627149 0.6271 ------Dr.22036.1.A1 at -1.46839 -2.25249 -1.89777 -2.65508 1 0.900674 1 0.440422 0.4404 zgc:172215 Zgc:17221 ------Dr.22059.1.S1 at -1.57078 -1.79539 -1.36881 -2.36793 1 1 1 0.779087 0.7791 ------Dr.22059.2.A1 at -1.69526 -2.2684 -1.5877 -2.89897 1 0.438771 1 0.133 0.133 ------Dr.22065.1.A1 at 1.031431 1.430131 2.292344 4.781314 1 1 0.956 0.023922 0.0239 wu:fd11b07 wu:fd11b07------Dr.22087.1.A1 at 1.177738 -1.4424 -2.05238 -1.78849 1 1 0.992952 1 0.993 wu:fd12f01 wu:fd12f01 ------Dr.22094.1.A1_at -1.18537 -2.63949 -2.97832 -2.62503 1 0.260437 0.436541 0.168703 0.1687 tbx3b T-box 3b --- regulation of transcription, DNA-dependent /// embryonic DNA binding /// transcription factor activity nucleus heart tube development /// regulation of transcription

Dr.22105.1.A1 at 1.773814 1.84668 2.068781 1.859424 1 1 0.961976 1 0.962 zgc:92006 zgc:92006 --- pseudouridine synthesis RNA binding /// pseudouridine synthase activity --- Dr.2211.1.A1 at 2.364962 3.013966 3.115489 1.522002 0.256959 0.162719 0.06636 1 0.0664 ------Dr.22133.1.S1 at -1.77344 -2.04521 -1.65069 -2.24556 1 0.99934 1 0.896215 0.8962 ------Dr.22149.1.A1 at 1.492821 -1.96823 -2.6511 -2.27398 1 1 0.676773 0.989 0.6768 zgc:92254 zgc:92254 --- metabolic process glutathione transferase activity cytoplasm Dr.22150.1.S1 at -2.95259 -3.68324 -2.33661 -1.93105 0.732725 0.25581 0.938751 1 0.2558 zgc:158314 zgc:158314--- regulation of transcription transcription regulator activity nucleus Dr.22150.2.A1 at -4.80685 -8.82806 -3.67126 -2.61828 0.27659 0.10355 0.228892 0.656176 0.1035 zgc:158314 zgc:158314--- regulation of transcription transcription regulator activity nucleus Dr.22172.1.A1_at 1.150319 -1.11593 -1.8271 -2.23501 1 1 1 0.898232 0.8982 acly ATP citrate --- metabolic process /// cellular carbohydrate metabolic catalytic activity /// ATP citrate synthase activity /// succinate- cytoplasm process CoA ligase (ADP-forming) activity /// binding /// ATP binding /// transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Dr.22186.1.A1 at 2.681412 3.568303 3.06334 2.575512 0.240668 0.09296 0.166141 0.42517 0.093 ------Dr.22227.1.A1 at 2.562438 2.479177 1.64883 1.715494 0.59434 0.555455 1 1 0.5555 wu:fd44g07 wu:fd44g07------Dr.22266.1.A1 at 1.144186 2.329772 1.645146 1.470316 1 0.690581 1 1 0.6906 wu:fe48e11 wu:fe48e11------Dr.22299.1.A1 at -2.0138 -1.66491 -1.66362 -2.54074 1 1 1 0.431 0.431 wu:fe24e09 wu:fe24e09------Dr.22329.1.A1_at -1.93963 -1.86894 -1.41575 -2.10755 1 1 1 0.989 0.989 galnt14 UDP-N-ace--- calcium ion transport calcium channel activity /// calcium ion binding /// sugar Golgi apparatus /// membrane /// integral to binding /// transferase activity /// transferase activity, membrane transferring glycosyl groups /// calcium channel inhibitor activity /// manganese ion binding Dr.22360.1.A1 at -2.25811 -1.71338 -2.44865 -2.05748 0.655328 1 0.348769 0.998961 0.3488 zgc:85890 zgc:85890 --- transport transporter activity membrane /// integral to membrane Dr.22371.1.A1 at -1.08631 1.455916 -1.57323 -2.0952 1 1 1 0.974234 0.9742 ------Dr.22374.1.A1 at -2.18032 -1.44159 -2.1077 -2.20511 0.979287 1 0.974668 0.955795 0.9558 wu:fj34h05 wu:fj34h05 ------Dr.22409.1.A1 at -1.34005 -1.73056 -1.41743 -2.33449 1 1 1 0.84183 0.8418 ------Dr.2241.1.S1 at 2.470367 2.765674 2.361407 1.747865 0.659887 0.686 0.732 1 0.6599 zgc:66176 /// zgc:77183 zgc:66176 ------Dr.22425.1.A1 at -1.14353 -1.62768 -2.1199 -1.88336 1 1 0.996674 1 0.9967 wu:fj67g12 wu:fj67g12 ------Dr.22464.1.A1 at -1.35017 -1.54273 -1.35373 -2.08317 1 1 1 0.998 0.998 ------Dr.22471.1.A1 at -1.83191 -2.10125 -1.55517 -1.99485 1 0.9997 1 1 0.9997 wu:fe38h02 wu:fe38h02------Dr.22479.1.A1 at -1.34377 -1.88991 -1.55119 -2.16288 1 1 1 0.958708 0.9587 ------Dr.22517.1.S1_at 1.232425 3.221443 4.541697 4.88017 1 0.657435 0.273312 0.239052 0.2391 LOC566223 Similar to C--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.22554.1.A1 at 1.042221 -1.42075 -1.97697 -3.35218 1 1 1 0.205538 0.2055 ------Dr.22567.1.S1 at -1.13675 -1.47491 -1.46872 -2.05455 1 1 1 0.999 0.999 wu:fj15c08 wu:fj15c08 ------Dr.2260.1.S1 at 1.432647 3.109826 3.344209 3.96793 1 0.1448 0.346204 0.058066 0.0581 pelo pelota hom--- translation --- nucleus Dr.22616.1.A1 at 2.588036 1.550048 1.071555 1.035894 0.563786 1 1 1 0.5638 wu:fj07d12 wu:fj07d12 ------Dr.22620.1.S1 at -2.31461 -2.73943 -2.43723 -2.06574 0.605518 0.151842 0.329625 0.981877 0.1518 zgc:65964 zgc:65964 ------Dr.22637.1.A1 at -1.36289 -4.7311 -3.33151 -3.79194 1 0.222297 0.260437 0.318066 0.2223 wu:fj30f03 wu:fj30f03 ------Dr.2265.1.A1 at 2.016661 2.344003 2.065441 2.739873 0.981877 0.208 1 0.123 0.123 LOC562808 similar to m------Dr.2266.1.A1 at -1.20185 -1.62929 -2.07902 -2.35362 1 1 0.982 0.647358 0.6474 wu:fc63c11 wu:fc63c11------Dr.22660.1.A1 at 1.24604 1.930144 2.023112 2.659424 1 1 1 0.394588 0.3946 ------Dr.2268.1.A1 at -1.42045 -1.389 -1.48729 -2.24824 1 1 1 0.983325 0.9833 wu:fc64c05 wu:fc64c05------Dr.22685.1.A1_at -1.32418 -1.34521 -1.96293 -2.14705 1 1 1 0.9997 0.9997 zgc:91929 zgc:91929 --- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein --- tyrosine/serine/threonine phosphatase activity /// hydrolase activity /// phosphatase activity /// MAP kinase tyrosine/serine/threonine phosphatase activity Dr.22693.1.A1 at 1.497681 1.50829 1.593013 2.231493 1 1 1 0.981 0.981 ------Dr.2270.1.A1 at 3.926189 3.359508 2.401457 1.412448 0.036696 0.031572 0.19357 1 0.0316 wu:fc64h01 wu:fc64h01------Dr.22705.1.A1 at -1.37887 -2.0778 -2.19265 -2.12782 1 0.981543 0.672567 0.714413 0.6726 im:7138837 im:7138837------ligase activity --- Dr.22709.1.S1 at 2.078422 -1.41054 -1.62195 -1.51198 0.994 1 1 1 0.994 wu:fj43h03 wu:fj43h03 ------Dr.22710.1.A1 at -1.31516 -1.7947 -1.91501 -2.02044 1 1 1 0.979 0.979 zgc:158375 zgc:158375--- cell adhesion structural molecule activity /// calcium ion binding --- Dr.22711.1.A1 at 1.149611 -1.9857 -1.27991 -2.59292 1 1 1 0.988927 0.9889 ------Dr.22713.1.A1 at -2.00424 -2.04322 -3.00803 -1.92228 0.999955 0.999955 0.541338 0.999955 0.5413 wu:fj44b04 wu:fj44b04 ------Dr.22720.1.A1 at 1.300449 -1.80446 -2.17834 -1.79789 1 1 0.948404 1 0.9484 ------Dr.22721.1.A1 at 1.103737 -1.83914 -2.39822 -2.58925 1 1 0.809205 0.696939 0.6969 wu:fj45a02 wu:fj45a02 ------Dr.22729.1.A1 at -1.21666 2.144867 4.3053 3.428434 1 0.994977 0.72 0.375312 0.3753 ------Dr.2273.1.S1 at 1.896015 3.186919 3.189441 3.483323 1 0.11808 0.098458 0.060737 0.0607 ard1a /// LOC100148691 ARD1 hom--- metabolic process N-acetyltransferase activity /// transferase activity --- Dr.22733.1.A1 at -2.62424 -5.74081 -9.21246 -7.43357 0.979 0.101194 0.032298 0.04356 0.0323 wu:fj46d11 wu:fj46d11 ------Dr.22757.1.A1 at -2.01542 -2.77392 -2.51961 -2.5831 0.996674 0.675565 0.709 0.784536 0.6756 wu:fj49b04 wu:fj49b04 ------Dr.22764.1.A1 at 1.09303 -2.4106 -3.7158 -3.28752 1 0.961976 0.352801 0.37084 0.3528 wu:fj51e11 wu:fj51e11 ------Dr.22774.1.A1 at 1.044332 -1.44251 -1.59605 -2.12193 1 1 1 0.993617 0.9936 si:dkey-266j7.1 si:dkey-266------Dr.22777.1.S1 at 2.51328 1.325083 1.209568 1.18626 0.822967 1 1 1 0.823 wu:fj53a09 wu:fj53a09 ------Dr.2278.1.A1_at 1.700306 2.16132 2.281994 2.029864 1 0.937 0.879 1 0.879 adam17a a disintegri--- proteolysis /// zinc ion transport /// integrin-mediated metalloendopeptidase activity /// endopeptidase inhibitor extracellular region signaling pathway activity /// metalloendopeptidase inhibitor activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding

Dr.22795.1.A1 at -1.68711 -2.92066 -3.4814 -3.00227 1 0.16655 0.045675 0.088553 0.0457 wu:fj56f11 wu:fj56f11 ------Dr.22801.1.A1 at -1.68239 -2.01681 -2.17036 -1.68181 1 0.994659 0.949321 1 0.9493 agl amylo-1, 6------Dr.22804.1.S1 at -1.16163 -1.03684 1.256118 3.095661 1 1 1 0.185881 0.1859 si:dkey-71l10.2 si:dkey-71l ------Dr.22818.1.A1 at 2.600118 2.695302 1.075191 -1.15659 0.940342 0.902772 1 1 0.9028 wu:fj60f08 wu:fj60f08 ------Dr.22830.1.A1 at -1.53643 -1.77428 -1.56293 -2.2483 1 1 1 0.787 0.787 zgc:163122 zgc:163122------acylphosphatase activity /// hydrolase activity --- Dr.22831.1.A1 at -1.32408 -2.48237 -2.8495 -2.08881 1 0.758 0.582776 0.999 0.5828 ------Dr.2286.1.A1 a at 1.003563 1.169874 1.223454 2.583007 1 1 1 0.24641 0.2464 wu:fc76b11 wu:fc76b11------Dr.2291.1.S1_at -1.46178 -1.04105 3.677655 5.823242 1 1 0.36288 0.065602 0.0656 mcm2 MCM2 min --- DNA replication initiation /// retina development in camera- nucleotide binding /// DNA binding /// ATP binding nucleus type eye Dr.22947.1.A1 at -1.1084 -1.14102 2.488324 1.613988 1 1 0.903 1 0.903 zgc:110290 zgc:110290--- phosphate transport phosphate transmembrane transporter activity integral to membrane Dr.22984.1.A1 at 3.09917 2.74342 2.493972 2.066364 0.013538 0.275049 0.769517 0.98838 0.0135 wu:fj82b05 wu:fj82b05 ------Dr.22988.1.A1 at 1.697843 2.202349 1.631154 2.144739 1 0.978746 1 0.999325 0.9787 wu:fj82d09 wu:fj82d09 ------Dr.22998.1.A1 at -1.3707 -1.4045 -1.2864 -2.1852 1 1 1 0.954634 0.9546 ------Dr.23030.1.A1 at -1.5915 -1.57147 -1.73498 -2.7769 1 1 1 0.339486 0.3395 wu:fj88f11 wu:fj88f11 ------Dr.23035.1.A1 at -1.42705 -1.91336 -2.10357 -1.57131 1 1 0.93178 1 0.9318 ------Dr.23041.1.A1 at -1.01822 -2.28541 -2.65687 -2.03988 1 0.945 0.583208 0.994816 0.5832 camk2b1 calcium/ca ------Dr.23064.1.S1 at -1.46518 -1.66074 -1.63569 -2.1073 1 1 1 0.998 0.998 zgc:194693 zgc:194693------Dr.23065.1.S1_at 1.141887 1.195164 1.5056 2.771586 1 1 1 0.180815 0.1808 musk muscle, sk--- protein amino acid phosphorylation /// motor axon guidance nucleotide binding /// protein kinase activity /// protein postsynaptic membrane /// negative regulation of axon extension /// receptor tyrosine kinase activity /// endopeptidase inhibitor activity /// clustering /// synaptic growth at neuromuscular junction cysteine protease inhibitor activity /// receptor activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// identical protein binding /// identical protein binding Dr.23073.1.A1 at 1.56327 2.388589 2.386765 4.199961 1 0.869645 0.978743 0.177806 0.1778 wu:fk03e08 wu:fk03e08------Dr.23096.1.A1_at -10.3356 -9.55186 -9.81026 -9.78231 0.079134 0.110698 0.09053 0.086992 0.0791 zgc:158414 zgc:158414------protein-lysine 6-oxidase activity /// scavenger receptor membrane activity /// copper ion binding Dr.23106.2.S1 at -2.02081 -2.05032 -2.25296 -2.29707 1 0.999955 0.998 0.995 0.995 ------Dr.23115.1.S1 at -1.39219 -1.97744 -1.36089 -2.16585 1 0.999955 1 0.992 0.992 wu:fk32g07 wu:fk32g07------Dr.23116.1.A1 at -1.42591 -1.49458 -1.52754 -2.01211 1 1 1 0.998 0.998 wu:fk32h10 wu:fk32h10------Dr.23128.1.A1 at 1.860831 3.936264 3.504467 2.392149 1 0.065982 0.213665 0.625 0.066 ------Dr.23154.1.A1 at 1.860019 2.202787 1.437383 1.203082 1 0.58 1 1 0.58 ------Dr.23156.1.S1 at 1.977838 2.567562 2.19 1.624946 1 0.105646 0.976443 1 0.1056 ccdc25 coiled-coil d------Dr.23163.1.A1 at -4.11519 -4.39053 -9.10256 -5.28681 0.16824 0.162 0.032206 0.051586 0.0322 ------Dr.23191.1.A1 at 5.195788 6.455842 7.896312 4.556593 0.042865 0.038812 0.035515 0.107269 0.0355 wu:fk50g02 wu:fk50g02------Dr.23196.1.A1 at -1.31098 -1.31717 1.149444 2.863311 1 1 1 0.532992 0.533 zgc:153352 zgc:153352------Dr.23212.1.A1 at 3.487475 4.474876 2.337533 1.487408 0.435885 0.223225 0.99 1 0.2232 ------Dr.23233.1.A1 at -1.49702 -1.78869 -1.58334 -2.0559 1 1 1 0.99934 0.9993 ------Dr.23240.1.A1 at -2.21836 -3.16686 -3.92534 -4.1564 0.940843 0.16456 0.036676 0.03463 0.0346 LOC100002334 hypothetica------Dr.23242.1.A1 at -1.55158 -2.27793 -3.2838 -2.24363 1 0.906353 0.168457 0.934556 0.1685 wu:fk53f01 wu:fk53f01 ------Dr.23271.1.A1 at -2.49181 1.026153 -1.44612 -1.28477 0.951689 1 1 1 0.9517 zgc:162144 zgc:162144------Dr.233.1.S1_at 1.65415 1.823219 1.845379 2.031419 1 1 1 0.997562 0.9976 nras neuroblasto--- small GTPase mediated signal transduction nucleotide binding /// GTP binding Golgi membrane /// intracellular /// Golgi apparatus /// plasma membrane /// membrane

Dr.2330.1.A1 at 2.12895 1.793576 1.485611 1.354506 0.894 1 1 1 0.894 rnd3b Rho family --- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular /// membrane Dr.23315.1.S1 at 1.37322 2.069309 1.53678 1.645855 1 0.945853 1 1 0.9459 ------Dr.23315.2.A1 at 1.624595 2.979254 2.510306 2.042305 1 0.009123 0.155888 1 0.0091 wu:fk81d06 wu:fk81d06------Dr.23324.1.A1_at 1.139856 1.051447 1.241028 3.614917 1 1 1 0.539927 0.5399 mmp14b matrix meta--- proteolysis /// calcium ion transport /// zinc ion transport /// catalytic activity /// metalloendopeptidase activity /// proteinaceous extracellular matrix metabolic process /// anterior/posterior axis specification /// endopeptidase inhibitor activity /// calcium channel activity /// cartilage development calcium ion binding /// metalloendopeptidase inhibitor activity /// peptidase activity /// metallopeptidase activity /// metallopeptidase activity /// zinc ion binding /// zinc ion binding /// hydrolase activity /// calcium channel inhibitor activity /// metal ion binding

Dr.23335.1.A1 at -2.30355 -1.90577 -2.1754 -2.15432 0.453675 1 0.757744 0.826239 0.4537 wu:fk92d04 wu:fk92d04------Dr.23353.1.S1 at 1.677696 2.664201 2.760332 3.024316 1 0.112409 0.353475 0.059359 0.0594 zgc:103632 zgc:103632--- mitosis --- spliceosome Dr.23355.1.A1 at -1.40334 -2.36644 -2.06766 -2.41704 1 0.896804 1 0.475172 0.4752 wu:fk98c08 wu:fk98c08------Dr.23368.1.A1 at 2.215913 1.988539 1.705699 1.257663 0.979287 1 1 1 0.9793 wu:fl05f04 wu:fl05f04 ------Dr.23369.1.S1 at -1.75385 -1.48676 -1.28204 -2.04517 1 1 1 0.995 0.995 LOC568010 similar to in------Dr.23372.1.A1 at -1.36084 -2.02662 -1.77113 -2.44692 1 0.999955 1 0.683267 0.6833 ------Dr.23377.1.S1 at -2.38236 -1.38617 -1.50217 -2.10124 0.984 1 1 0.99934 0.984 ------Dr.23415.1.A1 at 5.390805 2.644713 2.478536 2.060315 0.09873 0.713345 0.87365 1 0.0987 ------Dr.23416.1.A1 at -1.6072 -1.71328 -1.76683 -2.05818 1 1 1 0.999917 0.9999 ------Dr.23441.1.S1 at 2.107678 1.48457 1.283414 2.897082 0.991918 1 1 0.423209 0.4232 LOC791831 /// zgc:85644 hypothetica------Dr.23461.1.A1 at -1.33868 -1.5289 -3.07117 -2.27346 1 1 0.135227 0.990835 0.1352 stc2 /// zgc:136650 stanniocalc------hormone activity extracellular region Dr.23465.1.S1_at 1.360787 1.273338 -1.05198 4.559172 1 1 1 0.176297 0.1763 net1 neuroepithe--- intracellular signaling cascade /// regulation of Rho protein guanyl-nucleotide exchange factor activity /// Rho guanyl- intracellular signal transduction nucleotide exchange factor activity Dr.23467.1.S1_at -1.18814 -1.49035 -2.1475 -2.10827 1 1 0.959 0.984 0.959 cav2 caveolin 2 ------Golgi membrane /// Golgi apparatus /// membrane /// integral to membrane Dr.23472.1.S1 at 1.052266 -4.87995 -3.36801 -3.01839 1 0.25251 0.586866 0.73037 0.2525 sp5 Sp5 transc--- mesoderm morphogenesis nucleic acid binding /// zinc ion binding intracellular Dr.23479.1.S1 a at 1.428159 2.295393 1.927114 1.971825 1 0.763382 1 1 0.7634 ------Dr.23479.2.S1 at 1.310355 2.064984 1.814859 2.236447 1 0.982972 1 0.849904 0.8499 ------Dr.23479.2.S1 x at 1.488883 2.901628 2.103876 2.619018 1 0.213191 1 0.465134 0.2132 ------Dr.23495.1.S1 at -1.01833 1.245323 1.688309 2.45097 1 1 1 0.933 0.933 si:ch211-284b7.3 si:ch211-28------Dr.23512.1.A1 at -2.42475 -4.29448 -1.82339 -4.56801 0.547 0.11152 1 0.11967 0.1115 wu:fb05h10 wu:fb05h10------Dr.23513.1.S1_at 1.299114 -1.23461 -1.57764 -2.36886 1 1 1 0.978424 0.9784 cav1 caveolin 1 --- somitogenesis /// heart development /// cholesterol --- Golgi membrane /// Golgi apparatus /// absorption /// neuromast development /// notochord cell membrane /// integral to membrane vacuolation Dr.23519.1.A1 at 2.124507 1.850156 1.578901 1.860094 0.9997 1 1 1 0.9997 wu:fa97c07 wu:fa97c07------Dr.23559.1.S1_at -1.56815 -2.6717 -3.1622 -3.67653 1 0.268134 0.122741 0.061212 0.0612 zgc:92763 zgc:92763 ------protein disulfide oxidoreductase activity outer membrane-bounded periplasmic space

Dr.236.1.S1 at 1.98425 3.182132 3.542553 2.558058 0.99321 0.138933 0.029 0.15895 0.029 ------Dr.2360.1.S1 at -2.41543 -3.4521 -3.58039 -2.70549 0.552238 0.085785 0.08 0.288079 0.08 rhpn2 rhophilin, R--- signal transduction protein binding intracellular /// cytoplasm Dr.2361.1.S1_at 1.959615 3.12163 2.276226 1.99906 0.996244 0.457 0.999 0.999955 0.457 bc2 putative bre--- transport /// protein transport --- cytoplasm /// endosome /// membrane /// late endosome membrane Dr.2362.1.S1_at 1.113708 2.086607 2.332067 3.0685 1 0.997143 0.954469 0.352 0.352 orc3l origin recog--- DNA replication /// proteolysis DNA binding /// cysteine-type endopeptidase activity nuclear origin of replication recognition complex Dr.23628.1.A1 at -1.73108 -2.12163 -1.9151 -2.64007 1 0.997562 1 0.834843 0.8348 ------Dr.2365.1.A1 at -1.83624 -2.11792 -2.25562 -2.51334 1 0.999955 0.999955 0.930374 0.9304 zgc:110171 zgc:110171------protein binding --- Dr.23662.1.S1 at 1.786539 2.208818 2.304002 1.732919 1 0.978695 0.31863 1 0.3186 pdcl3 Phosducin---- apoptosis protein binding cytoplasm /// cytoplasm Dr.23664.1.A1 at 2.076731 2.347402 2.146097 3.060218 1 0.927417 0.81965 0.124421 0.1244 wu:fb30f12 wu:fb30f12 ------Dr.237.1.A1_at 1.652445 2.385894 2.392082 2.359558 1 0.96741 0.973527 0.968904 0.9674 LOC100149308 /// rpe similar to ri --- carbohydrate metabolic process /// metabolic process catalytic activity /// ribulose-phosphate 3-epimerase activity ---

Dr.23715.1.S1 at 1.877637 2.127694 1.962689 1.499215 1 0.985798 0.999955 1 0.9858 ------Dr.2373.1.A1 at 1.307765 2.01813 2.223843 1.704489 1 0.999917 0.862 1 0.862 zdhhc13 Zinc finger, --- zinc ion transport zinc ion binding /// metal ion binding --- Dr.23733.2.A1 at 1.327555 2.070675 2.208372 3.058586 1 0.999955 0.973527 0.35174 0.3517 ubxn1 UBX doma------cytoplasm Dr.23746.1.A1 at -1.66227 -2.26608 -1.73002 -3.5253 1 0.996244 1 0.551658 0.5517 ------Dr.23758.1.A1 at -1.73638 -2.0486 -1.37786 -2.28732 1 0.99934 1 0.907435 0.9074 wu:fa16a02 wu:fa16a02------Dr.2377.2.S1 at -1.69841 -1.8149 -1.38209 -2.14941 1 1 1 0.958311 0.9583 krt1-19d keratin, typ------structural molecule activity intermediate filament Dr.23775.1.A1 at 3.691642 5.623531 4.750081 2.236981 0.066117 0.025316 0.069847 0.924 0.0253 nap1l4 nucleosom--- nucleosome assembly --- nucleus Dr.23788.1.S1 at -1.16548 -2.03709 -3.21515 -2.80928 1 0.9997 0.047308 0.05546 0.0473 gstp1 glutathione --- metabolic process glutathione transferase activity /// transferase activity --- Dr.23788.2.A1 at 1.955254 4.855018 6.326993 9.559102 1 0.04367 0.026437 0.011054 0.0111 rplp2l ribosomal p--- translational elongation structural constituent of ribosome intracellular /// ribosome Dr.23788.4.S1_at 1.321477 2.362802 2.949917 3.729541 1 0.387792 0.02872 0.023332 0.0233 zgc:77139 zgc:77139 --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase cytosol /// proteasome core complex /// protein activity /// endopeptidase inhibitor activity /// peptidase complex activity /// hydrolase activity Dr.23792.1.S1 at 2.195286 5.766297 6.916194 7.068608 0.991636 0.168206 0.08078 0.073265 0.0733 s100u S100 calciu------calcium ion binding --- Dr.23797.1.S1 at 2.66182 3.612579 3.441515 3.677111 0.074821 0.029734 0.016288 0.009889 0.0099 psmd11b proteasome ------cytosol /// protein complex Dr.23805.1.A1 at 1.994275 2.206867 1.488372 1.166483 0.999 0.917 1 1 0.917 LOC572151 similar to P------Dr.23814.1.A1 at -1.34137 -2.48869 -2.84465 -2.23575 1 0.888 0.59714 0.959918 0.5971 wu:fb68d10 wu:fb68d10------Dr.23823.1.A1 at -1.6437 -2.05414 -3.91305 -2.35646 1 0.996964 0.33258 0.809205 0.3326 ------Dr.23827.1.A1 at -1.44826 -2.5852 -2.56833 -2.20432 1 0.473247 0.36088 0.527493 0.3609 wu:fc12a01 wu:fc12a01------Dr.23827.1.A1 s at -1.33101 -2.10885 -2.41687 -1.9744 1 0.998 0.573653 0.999955 0.5737 wu:fc12a01 wu:fc12a01------Dr.2385.1.S1_at 1.603142 1.996558 2.09621 2.407277 1 1 0.99934 0.855387 0.8554 zgc:85653 zgc:85653 --- transport /// intracellular protein transport /// vesicle- protein binding /// lipid binding plasma membrane /// coated pit /// membrane mediated transport /// clathrin adaptor complex /// clathrin coat of coated pit Dr.23872.1.A1 at 3.295563 3.938569 3.332431 3.465085 0.573262 0.214892 0.287668 0.227565 0.2149 ------Dr.23911.1.A1_at -2.10023 -1.9996 -2.33883 -2.19299 0.9997 0.999955 0.956 0.995911 0.956 slc20a1a solute carri--- transport /// phosphate transport inorganic phosphate transmembrane transporter activity /// membrane /// integral to membrane symporter activity Dr.23914.1.S1 at -1.57038 -1.77493 -2.11082 -1.8869 1 1 0.949741 1 0.9497 ------Dr.23916.1.S1 at 2.12654 -1.09516 -1.11057 1.139746 0.999 1 1 1 0.999 ------Dr.23917.1.S1_at -1.06427 1.736576 3.61923 3.512787 1 1 0.052105 0.07319 0.0521 atp2b1a ATPase, C--- transport /// ion transport /// cation transport /// calcium ion nucleotide binding /// catalytic activity /// calcium-transporting membrane /// integral to membrane transport /// metabolic process ATPase activity /// calcium ion binding /// ATP binding /// calcium ion transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Dr.23922.1.A1 at 1.835146 2.132351 1.581087 1.236574 1 0.99556 1 1 0.9956 wu:fd52d02 wu:fd52d02------Dr.23923.1.A1 at 1.287667 1.96958 2.350083 5.411369 1 0.999955 0.958184 0.062569 0.0626 ------Dr.2393.1.S1_at 2.268496 3.124227 3.146482 2.625115 0.95726 0.311661 0.216211 0.446741 0.2162 dohh deoxyhypus--- iron ion transport /// cellular iron ion homeostasis /// peptidyl- monooxygenase activity /// binding /// iron ion binding /// --- lysine modification to hypusine /// peptidyl-lysine oxidoreductase activity /// deoxyhypusine monooxygenase modification to hypusine /// oxidation reduction activity /// deoxyhypusine monooxygenase activity /// metal ion binding Dr.23930.1.S1 at 1.254383 1.725874 1.837922 2.148392 1 1 1 0.901 0.901 prpf40a PRP40 pre------protein binding --- Dr.23942.1.S1_at -1.14798 1.700443 3.482003 4.396703 1 1 0.37674 0.058345 0.0583 b3gnt5 UDP-GlcNA--- protein amino acid glycosylation galactosyltransferase activity /// transferase activity /// Golgi membrane /// Golgi apparatus /// transferase activity, transferring glycosyl groups membrane /// integral to membrane Dr.2395.1.A1_at 2.332805 3.05537 2.924505 2.661935 0.80077 0.239613 0.313 0.460584 0.2396 ublcp1 /// wu:fb33g09 ubiquitin-lik--- protein modification process phosphoprotein phosphatase activity /// hydrolase activity nucleus

Dr.2399.1.A1 at 2.670026 4.050436 3.561027 2.898452 0.545368 0.208725 0.222406 0.500834 0.2087 zgc:195326 zgc:195326------binding --- Dr.23996.1.A1_at 1.743552 3.320056 3.422097 2.740518 1 0.42 0.396733 0.848 0.3967 prmt3 protein argi--- metabolic process methyltransferase activity /// zinc ion binding /// S- intracellular adenosylmethionine-dependent methyltransferase activity /// transferase activity Dr.240.1.A1_at 1.47533 1.631138 1.943836 6.167243 1 1 1 0.011287 0.0113 timp2 tissue inhib------protein binding /// metalloendopeptidase inhibitor activity extracellular region /// proteinaceous extracellular matrix Dr.2400.1.A1 at -2.13556 -1.92518 -1.42226 -1.15537 0.831855 1 1 1 0.8319 wu:fl22c07 wu:fl22c07 ------Dr.24018.1.A1 at -1.4223 -1.57025 -1.58058 -2.02928 1 1 1 0.984725 0.9847 si:ch211-135f11.1 si:ch211-13------Dr.24021.1.A1_at 1.13106 1.989983 3.81317 3.476522 1 0.999955 0.243914 0.270166 0.2439 atp2b1a ATPase, C--- transport /// ion transport /// cation transport /// calcium ion nucleotide binding /// catalytic activity /// calcium-transporting membrane /// integral to membrane transport /// metabolic process ATPase activity /// calcium ion binding /// ATP binding /// calcium ion transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Dr.24032.1.S1 s at 1.238428 1.385201 1.318599 2.272079 1 1 1 0.57428 0.5743 btbd10b BTB (POZ ------Dr.24032.1.S1 x at 1.124326 1.284805 1.281593 2.220038 1 1 1 0.76275 0.7627 btbd10b BTB (POZ ------Dr.2404.1.S1 at 2.382441 2.871344 2.614181 3.0041 0.777366 0.339209 0.616305 0.270343 0.2703 edc4 enhancer o------nucleus /// cytoplasm Dr.2408.1.A1_at -2.38849 -2.7507 -2.55611 1.034206 0.976374 0.776432 0.948 1 0.7764 mmp2 matrix meta--- proteolysis /// calcium ion transport /// zinc ion transport /// catalytic activity /// metalloendopeptidase activity /// proteinaceous extracellular matrix metabolic process endopeptidase inhibitor activity /// calcium channel activity /// calcium ion binding /// metalloendopeptidase inhibitor activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// calcium channel inhibitor activity /// metal ion binding

Dr.24090.1.A1 at -3.15351 -2.73381 -4.15721 -3.92599 0.81438 0.52781 0.107075 0.286166 0.1071 LOC559941 similar to R------Dr.24104.1.S1_at 2.55207 2.641029 2.827364 2.845868 0.744245 0.692157 0.668489 0.555455 0.5555 rgl1 ral guanine --- signal transduction /// small GTPase mediated signal guanyl-nucleotide exchange factor activity intracellular transduction /// regulation of small GTPase mediated signal transduction Dr.24122.1.A1 at -1.15735 -1.16777 -1.63606 -2.18789 1 1 1 0.87774 0.8777 zfp36l1l zinc finger ------nucleic acid binding /// zinc ion binding --- Dr.2413.1.S1_at 1.304523 2.076412 2.110389 3.143824 1 0.996244 0.997322 0.231602 0.2316 dusp1 dual specif--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein --- tyrosine/serine/threonine phosphatase activity /// hydrolase activity /// phosphatase activity /// MAP kinase tyrosine/serine/threonine phosphatase activity Dr.24141.1.A1 x at 3.143603 3.47813 2.848834 2.332361 0.539733 0.21518 0.479 0.966 0.2152 wu:fc27e05 wu:fc27e05------actin binding --- Dr.2415.1.S1 at 1.029219 2.159714 1.938761 2.919162 1 0.779839 1 0.070105 0.0701 psmg2 proteasome --- proteasome assembly protein binding nucleus /// nucleus Dr.24150.1.A1 at 1.136589 2.086398 2.43083 2.177976 1 1 0.84129 0.996 0.8413 ------Dr.24162.1.A1 at 2.205745 2.434827 2.241597 2.530996 0.99 0.960456 0.971561 0.855 0.855 LOC100005813 similar to P------Dr.24162.1.A1 s at 2.034896 2.135606 1.947725 2.37261 0.99994 0.999955 1 0.929429 0.9294 LOC100005813 similar to P------Dr.2417.1.S1_at 2.170051 3.417618 3.54396 3.301154 0.999 0.076815 0.028278 0.076656 0.0283 cct3 chaperonin --- protein folding /// cellular protein metabolic process /// nucleotide binding /// protein binding /// ATP binding /// cytoplasm negative regulation of retinal cell programmed cell death /// unfolded protein binding embryonic eye morphogenesis Dr.2417.2.S1_at 1.460157 2.716711 2.920026 3.879171 1 0.175373 0.182833 0.028294 0.0283 zgc:92114 zgc:92114 --- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.24179.1.A1 at 2.400601 1.96874 1.077474 -1.12194 0.729 1 1 1 0.729 ------Dr.2418.1.A1 at -1.74937 -1.95215 -3.53646 -2.43776 1 1 0.303843 0.941866 0.3038 ------Dr.24192.1.S1_at 1.415219 2.099705 1.88953 1.570447 1 0.99934 1 1 0.9993 cars cysteinyl-tR--- translation /// cysteinyl-tRNA aminoacylation nucleotide binding /// cysteine-tRNA ligase activity /// ATP cytoplasm binding Dr.24196.1.S1_at 2.335216 3.873514 4.027404 2.520495 0.868 0.184953 0.12912 0.697428 0.1291 elavl1 ELAV (emb------nucleotide binding /// nucleic acid binding /// RNA binding ribonucleoprotein complex

Dr.24199.1.A1 s at 1.202859 1.79757 1.832304 2.707666 1 1 1 0.25077 0.2508 arpp19b cAMP-regu------Dr.24206.1.S1_at 1.643623 2.606469 2.71628 2.753262 1 0.566712 0.462 0.293526 0.2935 cct4 chaperonin --- response to hypoxia /// protein folding /// cellular protein nucleotide binding /// protein binding /// ATP binding /// cytoplasm metabolic process unfolded protein binding Dr.24208.1.S1_at 2.945633 5.19419 6.191451 4.984457 0.60936 0.114 0.138587 0.138578 0.114 abcf2 ATP-bindin------nucleotide binding /// ATP binding /// ATPase activity /// --- nucleoside-triphosphatase activity Dr.24214.1.S1_at -4.30381 -2.70047 -4.92361 -3.83929 0.252191 0.709 0.124242 0.231181 0.1242 sult1st1 sulfotransfe--- catecholamine metabolic process /// xenobiotic metabolic sulfotransferase activity /// sulfotransferase activity /// cytoplasm /// cytoplasm process transferase activity Dr.24217.1.S1_at 1.422117 4.223747 4.746259 4.397244 1 0.221767 0.220242 0.019154 0.0192 zgc:55584 zgc:55584 --- regulation of transcription, DNA-dependent /// zinc ion nucleic acid binding /// DNA binding /// zinc ion binding /// cytoplasm transport metal ion binding Dr.24221.1.S1 at 1.501458 2.257706 2.531515 2.007444 1 0.254659 0.052105 1 0.0521 arf5 ADP-ribosy--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.24222.1.A1 at -2.25713 -2.59605 -2.14777 -3.0151 0.998 0.983 0.999917 0.903 0.903 LOC564633 similar to P------Dr.24235.1.A1_at 4.043821 5.273658 5.248282 4.478653 0.051233 0.015764 0.016343 0.019252 0.0158 ddx18 DEAD (Asp------nucleotide binding /// nucleic acid binding /// helicase activity --- /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.24235.2.S1_at 1.583454 2.207599 2.363105 1.969811 1 0.60138 0.514 1 0.514 ddx18 DEAD (Asp------nucleotide binding /// nucleic acid binding /// helicase activity --- /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.24241.1.S1_at 2.247506 1.295582 -1.33126 1.143797 0.977 1 1 1 0.977 mdkb midkine-rel--- brain development /// neural crest formation /// positive growth factor activity extracellular region regulation of neuron differentiation Dr.24241.2.A1 at 1.428424 2.074607 2.279282 3.071166 1 0.997322 0.996 0.287668 0.2877 LOC555279 similar to tr ------Dr.24242.1.A1 at 1.625773 2.800773 3.214384 3.077149 1 0.212648 0.180204 0.104318 0.1043 ------Dr.24245.2.S1_a_at 1.345651 2.738007 2.408944 2.134182 1 0.009615 0.029749 0.099 0.0096 snd1 staphylococ--- RNA interference nucleic acid binding /// nuclease activity /// protein binding /// cytoplasm /// cytoplasm /// RNA-induced hydrolase activity, acting on ester bonds silencing complex Dr.24246.1.S1 at 1.600317 -3.40889 -3.84865 -2.95772 1 0.163615 0.087384 0.328098 0.0874 h1fx H1 histone --- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.24247.1.S1_at 2.033185 2.446802 2.537876 1.840378 0.999955 0.418385 0.670811 1 0.4184 riok2 RIO kinase --- protein amino acid phosphorylation protein kinase activity /// protein serine/threonine kinase --- activity /// ATP binding /// kinase activity Dr.24257.1.S1 at -1.58477 -1.88997 -1.38916 -2.31593 1 1 1 0.880907 0.8809 tnni2a.2 troponin I, s------Dr.24258.1.S1_at -1.36064 -1.74463 -1.3873 -2.10556 1 1 1 0.951 0.951 sult1st2 sulfotransfe--- catecholamine metabolic process /// lipid metabolic process sulfotransferase activity /// sulfotransferase activity /// cytoplasm /// cytoplasm /// xenobiotic metabolic process /// steroid metabolic transferase activity process Dr.24262.1.A1_at 2.535412 2.093977 2.148609 1.283988 0.126621 0.922 0.804302 1 0.1266 plekhh1 pleckstrin h--- patterning of blood vessels /// multicellular organismal binding cytoskeleton development /// axon guidance /// blood vessel morphogenesis Dr.24292.2.S1_at 1.805944 3.299257 2.82779 1.591864 1 0.09433 0.195332 1 0.0943 zgc:92026 zgc:92026 --- biosynthetic process mannose-1-phosphate guanylyltransferase activity /// --- acyltransferase activity /// transferase activity /// nucleotidyltransferase activity Dr.24292.3.A1 a at 1.524347 2.13249 1.518132 1.136518 1 0.864 1 1 0.864 lrrn1 leucine rich ------protein binding --- Dr.24315.1.S1_at -1.31746 -1.72335 -1.63469 -2.35619 1 1 1 0.964528 0.9645 ca7 carbonic an--- one-carbon compound metabolic process /// zinc ion carbonate dehydratase activity /// zinc ion binding /// metal --- transport ion binding Dr.24327.1.S1_at 1.302924 1.912249 2.096895 2.187524 1 1 0.717532 0.746211 0.7175 cmpk cytidylate k --- nucleobase, nucleoside, nucleotide and nucleic acid nucleotide binding /// cytidylate kinase activity /// ATP nucleus /// cytoplasm metabolic process /// pyrimidine nucleotide biosynthetic binding /// kinase activity /// transferase activity /// process phosphotransferase activity, phosphate group as acceptor /// nucleotide kinase activity /// nucleobase, nucleoside, nucleotide kinase activity Dr.24333.1.A1 s at 1.643571 2.107393 2.352148 2.008258 1 1 0.625 1 0.625 zgc:136866 zgc:136866------Dr.24339.1.S1_at 1.322622 -1.94255 -2.55269 -2.1996 1 1 0.874497 0.979955 0.8745 ndrg4 N-myc dow--- heart looping /// embryonic heart tube development /// phosphopantetheine binding --- cardiac muscle cell proliferation Dr.24345.1.A1 at -1.20222 -2.45371 -2.24992 -1.684 1 0.551792 0.67249 1 0.5518 wu:fa99c11 wu:fa99c11------Dr.24347.2.A1 at -1.46276 -1.91812 -1.47118 -2.35928 1 1 1 0.618 0.618 ------Dr.24351.1.A1 at -1.6068 -1.99498 -1.21435 -2.42604 1 1 1 0.906353 0.9064 wu:fb08c08 wu:fb08c08------Dr.24379.1.S1_at -1.42649 -1.45571 -1.07595 7.828273 1 1 1 0.009911 0.0099 cdc2 cell division --- protein amino acid phosphorylation /// cell division nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.2438.1.S1 at 21.74857 32.42807 15.93486 9.049041 0.031727 0.010141 0.009976 0.022118 0.01 cpa2 carboxypep--- proteolysis carboxypeptidase activity /// zinc ion binding --- Dr.24387.1.A1 at 1.42039 2.153952 2.33344 2.015979 1 0.845 0.349 0.999 0.349 wu:fc03d12 wu:fc03d12------Dr.244.1.A1 at 2.23821 2.058043 2.053553 1.85682 0.930374 0.999955 0.99994 1 0.9304 akap1 A kinase (P------nucleic acid binding /// RNA binding --- Dr.2445.1.A1 at -1.86354 -2.19911 -2.35385 -1.9663 1 0.915889 0.768 0.99994 0.768 wu:faa16g05 wu:faa16g0------Dr.24461.1.A1 a at -1.42436 -1.75345 -1.28765 -2.13407 1 1 1 0.949321 0.9493 ------Dr.24461.2.A1 x at -1.5024 -1.80096 -1.35673 -2.00927 1 1 1 0.99994 0.9999 ------Dr.24476.1.S1_at 1.616105 1.894178 2.190745 2.11917 1 1 0.979287 0.99934 0.9793 zgc:123330 zgc:123330--- mitochondrial electron transport, ubiquinol to cytochrome c ubiquinol-cytochrome-c reductase activity ---

Dr.24483.1.S1 at -1.87055 -2.12477 -1.68702 -2.3498 1 0.982 1 0.795563 0.7956 ------Dr.24499.1.A1 at 2.149491 3.056643 2.129143 2.124519 0.932201 0.118912 0.996244 0.9997 0.1189 ------Dr.24527.1.S1 at 2.441653 2.888322 2.549115 2.89747 0.155472 0.036105 0.604 0.052812 0.0361 eif4g2a eukaryotic t--- mesoderm development /// RNA metabolic process binding /// protein binding --- Dr.24531.1.S1 at -1.62829 -2.22115 -1.49468 -2.20091 1 0.935201 1 0.554893 0.5549 ------Dr.24533.1.A1 at -2.05429 -1.99032 -2.03605 -1.48315 0.951256 0.999955 0.999955 1 0.9513 ------Dr.24558.1.S1_at 1.958955 3.245802 3.114217 2.848076 0.996244 0.118738 0.098635 0.121495 0.0986 srp9 signal reco--- SRP-dependent cotranslational protein targeting to protein binding /// 7S RNA binding signal recognition particle membrane /// negative regulation of translational elongation

Dr.24562.1.S1 a at 11.10246 10.44709 8.560605 6.021746 0.007238 0.007364 0.017729 0.00534 0.0053 mvp major vault ------cytoplasm /// ribonucleoprotein complex Dr.24581.1.S1 at 1.05901 1.051967 1.444295 2.217656 1 1 1 0.905 0.905 sptbn2 spectrin, be------Dr.24582.1.S1_at 1.904715 2.920961 3.117258 2.931217 1 0.297124 0.318952 0.403675 0.2971 eif2s1l eukaryotic t--- translation RNA binding /// translation initiation factor activity eukaryotic translation initiation factor 2 complex Dr.24633.1.S1_a_at -1.10817 1.581959 2.043324 2.440386 1 1 1 0.249 0.249 zgc:109888 zgc:109888--- translation /// zinc ion transport structural constituent of ribosome /// zinc ion binding /// intracellular /// ribosome /// ribonucleoprotein metal ion binding complex Dr.24633.1.S1_at -1.3641 1.227175 1.8592 2.391582 1 1 1 0.429253 0.4293 zgc:109888 zgc:109888--- translation /// zinc ion transport structural constituent of ribosome /// zinc ion binding /// intracellular /// ribosome /// ribonucleoprotein metal ion binding complex Dr.24633.2.S1_a_at -1.1323 1.435466 1.910395 2.326105 1 1 1 0.59187 0.5919 zgc:109888 zgc:109888--- translation /// zinc ion transport structural constituent of ribosome /// zinc ion binding /// intracellular /// ribosome /// ribonucleoprotein metal ion binding complex Dr.24633.3.S1_at 1.297769 1.769773 2.144204 2.372838 1 1 0.941454 0.636772 0.6368 cirbp /// eef1d cold induci--- translation /// translational elongation nucleotide binding /// nucleic acid binding /// translation eukaryotic translation elongation factor 1 elongation factor activity complex Dr.24646.1.S1 at -1.26787 -2.10129 -1.24264 -2.18768 1 0.971702 1 0.982587 0.9717 ------Dr.24671.1.S1_at 1.306541 2.323761 2.912182 3.527227 1 0.418355 0.024 0.012354 0.0124 rpl27 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.24753.1.S1_at 1.383956 2.391257 5.814531 5.912274 1 0.43725 0.022647 0.026437 0.0226 ccnd1 cyclin D1 --- cell cycle /// camera-type eye morphogenesis /// cell division --- nucleus

Dr.24753.1.S2_at 1.328408 2.033345 4.356062 4.788724 1 0.994 0.020389 0.036281 0.0204 ccnd1 cyclin D1 --- cell cycle /// camera-type eye morphogenesis /// cell division --- nucleus

Dr.24758.2.S1 at 2.181295 2.777783 3.212476 3.212252 0.970026 0.454253 0.298635 0.25581 0.2558 marcks myristoylate------calmodulin binding /// kinase activity --- Dr.24760.2.A1_at 1.963683 2.260167 2.128043 1.658829 0.999955 0.991488 0.998 1 0.9915 aebp2 AE binding --- transcription /// transcription termination /// regulation of DNA binding /// zinc ion binding /// metal ion binding intracellular /// nucleus transcription, DNA-dependent /// zinc ion transport /// chromatin modification /// transcription antitermination

Dr.24762.1.S1_at 2.556384 3.961738 4.115456 3.765143 0.152 0.023123 0.02172 0.020769 0.0208 zc3h15 zinc finger --- zinc ion transport nucleic acid binding /// zinc ion binding /// metal ion binding nucleus /// cytoplasm

Dr.24763.1.S1 at -2.16638 2.38567 5.749532 11.78326 0.998 0.949 0.14849 0.041705 0.0417 wu:fb18c02 wu:fb18c02------Dr.24796.1.S1_at 1.508595 2.957597 3.858089 5.096844 1 0.163901 0.020601 0.01369 0.0137 zgc:73149 zgc:73149 --- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.24802.1.S1 a at 2.268647 3.925023 3.105148 3.343342 0.859853 0.025345 0.063491 0.04967 0.0253 hspa8 heat shock --- response to stress nucleotide binding /// ATP binding --- Dr.24814.1.S1_at 1.207151 2.349813 1.764758 1.484365 1 0.525 1 1 0.525 sec61al1 Sec61 alph--- transport /// protein transport /// intracellular protein P-P-bond-hydrolysis-driven protein transmembrane endoplasmic reticulum /// endoplasmic transport across a membrane transporter activity reticulum membrane /// membrane /// integral to membrane Dr.24815.1.S1_at 1.404673 3.009776 3.510661 4.510071 1 0.49675 0.31863 0.148593 0.1486 rpl13 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.24815.2.S1 at 1.169038 2.257733 3.218589 4.020532 1 0.851586 0.030197 0.008595 0.0086 rps29 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.24816.1.S1 a at 1.937598 2.222562 2.003563 1.519272 0.999955 0.947794 1 1 0.9478 zgc:56703 zgc:56703 --- protein folding heat shock protein binding /// unfolded protein binding --- Dr.24841.1.S1_at 3.272737 4.157718 3.616173 3.260091 0.324867 0.159 0.220744 0.311289 0.159 eif4a1a eukaryotic t------nucleic acid binding /// translation initiation factor activity /// --- helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.24841.2.S1 at 3.06613 3.601158 3.458739 3.324207 0.234495 0.117 0.147055 0.147656 0.117 ------Dr.24858.1.S1_at -1.28959 -1.36562 -1.03738 3.194458 1 1 1 0.382304 0.3823 zgc:110540 zgc:110540--- nucleobase, nucleoside, nucleotide and nucleic acid deoxycytidine kinase activity /// ATP binding /// kinase --- metabolic process activity /// transferase activity /// phosphotransferase activity, alcohol group as acceptor Dr.24858.2.S1_s_at 1.475447 2.15534 2.372494 2.820725 1 0.999917 0.826239 0.286166 0.2862 ppil1 peptidylpro--- protein folding peptidyl-prolyl cis-trans isomerase activity /// isomerase --- activity Dr.24868.1.A1_at 2.353755 3.650658 3.091557 1.79377 0.614 0.037883 0.362416 1 0.0379 glulb glutamate-a--- glutamine biosynthetic process /// nitrogen compound catalytic activity /// glutamate-ammonia ligase activity /// --- metabolic process ligase activity Dr.24882.2.S1_at 2.037807 1.73974 1.117002 -1.14499 0.991 1 1 1 0.991 atp1b2a ATPase, N--- transport /// ion transport /// potassium ion transport /// sodium:potassium-exchanging ATPase activity membrane /// integral to membrane sodium ion transport Dr.24885.1.S1 a at 1.809381 3.348911 3.715413 3.809316 1 0.061321 0.099368 0.033452 0.0335 snrpfl small nucle--- mRNA metabolic process nucleic acid binding ribonucleoprotein complex Dr.24887.1.S1 at -1.38793 -1.80191 -1.61375 -2.21716 1 1 1 0.137165 0.1372 ------Dr.24903.1.S1_at 1.102137 1.834223 2.101542 2.276019 1 1 0.996244 0.725611 0.7256 zgc:66168 zgc:66168 --- translation /// protein modification process /// protein amino nucleotide binding /// structural constituent of ribosome /// intracellular /// ribosome acid phosphorylation protein kinase activity /// protein serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.24916.1.S1 at -1.61297 -2.04336 -2.03543 -1.55271 1 0.989 0.999955 1 0.989 mbd3b methyl-CpG------DNA binding nucleus Dr.24916.2.S1 at 1.59128 2.055836 2.095503 2.424603 1 0.966986 0.9997 0.337573 0.3376 dcun1d5 DCN1, defe------Dr.24921.2.S1_at 1.456694 2.694642 3.388411 4.411671 1 0.557 0.174454 0.058803 0.0588 rpl38 ribosomal p--- translation structural constituent of ribosome /// structural molecule intracellular /// ribosome /// tight junction /// activity membrane /// integral to membrane /// ribonucleoprotein complex Dr.24922.1.S1_at 1.115289 1.612255 1.870222 2.028851 1 1 1 0.995 0.995 rps18 ribosomal p--- translation /// multicellular organismal development nucleic acid binding /// RNA binding /// structural constituent intracellular /// cytoplasm /// ribosome /// of ribosome /// rRNA binding ribonucleoprotein complex Dr.24928.1.S1 at 1.791899 2.001472 1.603652 1.075507 1 0.99934 1 1 0.9993 sb:cb589 sb:cb589 ------Dr.24928.2.S1 a at 1.96471 2.155264 1.768334 1.157865 0.99934 0.933 1 1 0.933 zgc:153632 zgc:153632------protein binding, bridging /// actin filament binding --- Dr.24930.1.S1 at 4.180947 5.035412 4.071691 3.839324 0.123491 0.151814 0.138387 0.189828 0.1235 c20orf45 chromosom------Dr.24932.1.S1 at 2.132546 3.975639 4.840327 5.676892 1 0.622 0.322296 0.402539 0.3223 zgc:92868 zgc:92868 --- translation structural constituent of ribosome intracellular /// ribosome Dr.24938.1.S1 a at -2.7153 -1.83676 -2.94256 -1.45484 0.999955 1 0.996882 1 0.9969 sb:cb846 sb:cb846 ------Dr.24938.1.S1 x at -2.0432 -1.5514 -2.20555 -1.98921 1 1 0.999325 1 0.9993 LOC100151188 hypothetica------Dr.24943.1.S1 at 2.183932 1.422434 1.204045 -1.09893 0.933631 1 1 1 0.9336 dsg2 desmoglein ------Dr.24945.1.S1_at 1.286868 3.270011 14.7488 14.23963 1 0.294861 0.009311 0.014909 0.0093 orc6l origin recog--- DNA replication DNA binding nuclear origin of replication recognition complex Dr.24951.1.A1 at -1.46922 -1.89389 -2.53312 -2.82443 1 1 0.990497 0.647744 0.6477 lrrc8a leucine rich ------protein binding --- Dr.24952.2.S1 a at 1.403951 2.194522 2.506831 3.347171 1 0.9997 0.911288 0.44088 0.4409 LOC402883 hypothetica------Dr.24960.1.S1 at -1.44964 -1.51132 -1.69647 -2.16103 1 1 1 0.994582 0.9946 dio1 deiodinase ------thyroxine 5'-deiodinase activity /// selenium binding --- Dr.24974.1.S1_at -1.8648 -2.08983 -1.12882 -1.37342 1 0.999 1 1 0.999 chd1l chromodom------nucleotide binding /// nucleic acid binding /// DNA binding /// intracellular /// nucleus helicase activity /// ATP binding /// hydrolase activity

Dr.24975.1.S1_at -1.86609 -4.50324 -4.00168 -3.03875 0.999955 0.080491 0.097398 0.41 0.0805 LOC100150694 /// pdgfrl similar to p --- protein amino acid phosphorylation receptor activity /// vascular endothelial growth factor --- receptor activity /// protein binding /// ATP binding /// identical protein binding Dr.24976.1.S1 at -1.11669 3.032633 1.940073 1.076374 1 0.839414 1 1 0.8394 CH211-2K18.1 /// igfbp5 insulin-like --- regulation of cell growth insulin-like growth factor binding extracellular region Dr.24983.1.S1 at 1.961518 2.105035 2.044213 1.465752 1 0.999955 0.998 1 0.998 polr3f polymerase --- transcription /// retina development in camera-type eye DNA binding /// DNA-directed RNA polymerase activity nucleus Dr.24995.5.A1_at -2.44275 -1.99252 -2.39162 -2.27438 0.110859 0.999955 0.236465 0.297 0.1109 zgc:65956 zgc:65956 --- L-serine biosynthetic process /// metabolic process catalytic activity /// phosphoglycerate dehydrogenase activity --- /// binding /// oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor /// cofactor binding /// NAD binding Dr.24995.6.A1_at 1.59966 1.995721 2.078713 2.374529 1 0.9997 0.997562 0.104977 0.105 spcs3 signal pept--- signal peptide processing --- signal peptidase complex /// integral to membrane Dr.25000.1.S1 at 1.145579 -2.26717 -2.36579 -1.88808 1 0.992731 0.925 1 0.925 wu:fb10g08 wu:fb10g08------Dr.2502.1.A1 at 2.833783 3.902717 2.849854 2.63909 0.594466 0.15 0.756 0.696939 0.15 wu:fb81e07 wu:fb81e07------Dr.25033.1.A1 at 1.627211 2.05104 2.297335 2.769041 1 0.99994 0.938 0.65029 0.6503 LOC557789 similar to M------Dr.25042.1.A1 at 1.214211 1.850613 2.10021 1.921123 1 1 0.9997 1 0.9997 si:ch211-258l4.7 si:ch211-25------Dr.25051.1.S2 at 1.203357 2.210682 2.382622 4.174992 1 0.889651 0.812449 0.072891 0.0729 lmnb1 lamin B1 ------structural molecule activity intermediate filament Dr.25063.1.S1 at -1.50319 -1.69595 -2.18283 -1.83141 1 1 0.86 1 0.86 zgc:63622 Zgc:63622 ------Dr.2509.1.A1 a at 1.601015 2.146893 1.617494 1.476932 1 0.997562 1 1 0.9976 pdcd6ip programme------Dr.25096.1.S1 at -3.16523 -3.72217 -3.60863 -3.34252 0.22243 0.118834 0.135857 0.187085 0.1188 ------Dr.25102.1.A1 at -1.65198 -1.65504 -2.39892 -2.40482 1 1 0.757 0.607965 0.608 tob1b transducer ------Dr.25120.2.S1 at 2.077418 2.760127 2.525834 2.629868 0.9997 0.112409 0.308 0.186053 0.1124 sf3a3 splicing fac------nucleic acid binding /// zinc ion binding intracellular /// nucleus Dr.25120.3.S1_at -2.27047 -1.44597 -1.33086 -1.66267 0.999 1 1 1 0.999 cd99l2 CD99 antig--- cell adhesion /// negative regulation of signal transduction protein binding signal recognition particle, endoplasmic reticulum targeting /// plasma membrane /// membrane /// integral to membrane /// cell junction Dr.25133.1.S1_at -2.24627 -1.45848 -1.91553 -1.84333 0.985207 1 1 1 0.9852 mcl1b myeloid cel --- apoptosis /// regulation of apoptosis /// chordate embryonic ------development /// negative regulation of apoptosis /// negative regulation of caspase activity Dr.25140.6.S1 at -1.90578 -3.41362 -3.9844 -4.2054 1 0.255 0.098697 0.152297 0.0987 pcp4a Purkinje ce------Dr.25147.1.S1 at 1.432976 2.111587 1.824693 1.742545 1 0.99934 1 1 0.9993 zp3b zona pelluc------Dr.25154.1.S1_at 3.100239 4.30687 3.020212 3.346199 0.318952 0.032319 0.299 0.1118 0.0323 map2k1 mitogen-ac--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.2516.1.S1_at -1.33901 -1.44327 -1.13296 2.059244 1 1 1 0.989 0.989 sass6 spindle ass--- nuclear division /// cell cycle /// mitotic spindle organization --- centrosome /// centrosome and biogenesis /// spermatogenesis /// embryonic cleavage /// centrosome duplication Dr.25167.1.S1_at -1.16965 -1.73469 -1.6328 -2.01192 1 1 1 0.9997 0.9997 elavl3 ELAV (emb------nucleotide binding /// nucleic acid binding /// RNA binding ribonucleoprotein complex

Dr.25174.1.A1 at -2.36978 -1.76234 -1.51132 -1.87211 0.861 1 1 1 0.861 tcf12 Transcriptio--- regulation of transcription transcription regulator activity nucleus Dr.25176.5.A1 at -2.29764 -3.29571 -3.00723 -1.92325 0.96723 0.490775 0.521302 1 0.4908 wu:fc58e01 wu:fc58e01------Dr.25176.7.S1 at -2.48491 -3.61196 -2.71009 -2.69355 0.423209 0.091582 0.20545 0.362 0.0916 ------Dr.25177.1.S1 at 1.254052 2.033434 1.618691 1.783957 1 0.981877 1 1 0.9819 calr calreticulin --- protein folding calcium ion binding /// unfolded protein binding endoplasmic reticulum Dr.25179.1.S1 at 2.228508 1.889281 1.482102 1.11679 0.872327 1 1 1 0.8723 ------Dr.2518.1.A1 at 1.90823 -2.22993 -1.88004 -3.39541 1 0.986338 1 0.547 0.547 wu:fb51f10 wu:fb51f10 ------Dr.25182.2.S1 at -1.17758 -1.18582 1.000206 4.261928 1 1 1 0.054528 0.0545 zgc:101026 zgc:101026--- cell cycle cyclin-dependent protein kinase regulator activity --- Dr.25185.1.S1 s at -1.42991 -1.83249 -1.26357 -2.3462 1 1 1 0.696541 0.6965 im:6791170 im:6791170------Dr.25185.1.S1 x at -1.55519 -1.7401 -1.18544 -2.24418 1 1 1 0.908 0.908 im:6791170 im:6791170------Dr.25185.2.S1 a at -1.6217 -2.03151 -1.27188 -2.66029 1 1 1 0.571 0.571 si:busm1-79m10.1 si:busm1-7 ------Dr.25185.2.S1 x at -1.58691 -2.06975 -1.37319 -2.56471 1 0.999955 1 0.64909 0.6491 si:busm1-79m10.1 si:busm1-7 ------Dr.25189.1.S1_at 1.211063 1.966468 2.544208 2.463206 1 1 0.65638 0.631 0.631 vcp valosin con------nucleotide binding /// binding /// ATP binding /// hydrolase --- activity /// nucleoside-triphosphatase activity Dr.25190.1.S1_at -1.56528 -1.44343 -1.13087 4.624945 1 1 1 0.043608 0.0436 ccna2 cyclin A2 --- cell cycle /// cell division /// retina development in camera- --- nucleus type eye Dr.25202.1.A1 s at 1.232171 2.006024 1.716035 1.216944 1 0.99994 1 1 0.9999 znf259 zinc finger ------protein binding /// zinc ion binding --- Dr.25212.1.A1_at -1.39242 -1.85327 -2.49399 -2.39978 1 1 0.960456 0.857 0.857 clstn1 calsyntenin --- proteolysis /// calcium ion transport /// homophilic cell cysteine-type endopeptidase activity /// calcium channel membrane adhesion activity /// calcium ion binding /// calcium channel inhibitor activity Dr.25217.1.S1 at 1.720144 2.659072 2.470327 2.120067 1 0.372889 0.800733 0.995813 0.3729 slc1a4 solute carri--- dicarboxylic acid transport sodium:dicarboxylate symporter activity membrane Dr.25223.1.A1 at 1.48443 2.160687 2.135708 2.739634 1 0.88 0.998 0.262728 0.2627 ------Dr.25226.1.S1 s at -1.72543 -1.74517 -1.28377 2.393157 1 1 1 0.687476 0.6875 ccnb1 cyclin B1 --- cell cycle /// cell division --- nucleus Dr.25228.2.S1 at -1.45761 -1.75196 -1.39977 -2.13392 1 1 1 0.951728 0.9517 ------Dr.25238.1.A1 at -3.45727 -3.81491 -5.06934 -4.15712 0.552238 0.255931 0.119941 0.216211 0.1199 tom1 target of my--- intracellular protein transport --- intracellular Dr.25238.1.A1 x at -3.53386 -3.64322 -5.39491 -4.07461 0.427834 0.210593 0.065602 0.181275 0.0656 tom1 target of my--- intracellular protein transport --- intracellular Dr.25248.1.A1 at -1.50162 -2.18025 -2.08729 -2.71933 1 0.890234 0.997 0.581124 0.5811 tmem195 transmemb------membrane /// integral to membrane Dr.25248.2.S1 at -1.91757 -2.1109 -2.03057 -2.42089 1 0.999955 1 0.95897 0.959 tmem195 transmemb------membrane /// integral to membrane Dr.2525.1.A1 at 1.35751 1.544105 2.04623 2.245669 1 1 1 0.951 0.951 fxn frataxin --- cellular iron ion homeostasis --- mitochondrion Dr.25251.1.A1_at 2.547408 2.796572 2.892778 3.112565 0.972478 0.693772 0.276728 0.152394 0.1524 mybbp1a MYB bindin--- carbohydrate metabolic process /// transcription /// DNA binding /// DNA-directed DNA polymerase activity /// nucleus transcription termination /// regulation of transcription, DNA- hydrolase activity, hydrolyzing O-glycosyl compounds /// dependent /// transcription antitermination binding Dr.25255.1.A1 at -1.10808 -1.28267 -1.03313 2.445762 1 1 1 0.760449 0.7604 ------Dr.25257.1.A1_at -4.65816 1.04592 -1.31785 1.043422 0.326831 1 1 1 0.3268 bhlhb3l basic helix---- transcription /// transcription termination /// regulation of DNA binding /// transcription repressor activity /// nucleus transcription, DNA-dependent /// transcription transcription regulator activity antitermination /// regulation of transcription Dr.25264.2.S1_at 1.894337 3.591927 4.487987 5.99383 1 0.157742 0.041146 0.018103 0.0181 rps15 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex

Dr.2528.1.S1 x at 1.628005 2.228566 2.422524 2.104354 1 0.994186 0.164721 0.999955 0.1647 wdr3 WD repeat --- rRNA processing --- small-subunit processome Dr.25283.1.A1_at 2.757478 2.395789 1.415416 1.106071 0.23809 0.359 1 1 0.2381 atp1b2a ATPase, N--- transport /// ion transport /// potassium ion transport /// sodium:potassium-exchanging ATPase activity membrane /// integral to membrane sodium ion transport Dr.25284.1.A1_at 2.177792 2.873123 2.924949 3.305434 0.921 0.349432 0.079569 0.051115 0.0511 kpnb1 karyopherin --- protein import into nucleus, docking /// intracellular protein binding /// protein transporter activity nucleus /// nuclear pore /// cytoplasm transport Dr.25287.1.A1 at 1.786189 2.911575 2.538303 2.340959 0.999955 0.571464 0.893594 0.948 0.5715 tia1 cytotoxic gr ------nucleotide binding /// nucleic acid binding --- Dr.25291.1.S1 at -3.11398 -1.64866 -2.37141 1.116938 0.994 1 0.998 1 0.994 LOC795545 hypothetica------Dr.25291.2.A1 at 1.491886 2.713123 3.446339 5.584535 1 0.58549 0.093623 0.031589 0.0316 rps10 ribosomal p------ribosome Dr.25291.5.A1_at 1.347253 2.815953 3.013694 4.698132 1 0.334 0.381442 0.057317 0.0573 rpl26 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// large ribosomal subunit Dr.25294.2.S1_at 1.240647 1.709019 1.791175 2.201009 1 1 1 0.966 0.966 uba1 ubiquitin-lik--- protein modification process /// metabolic process nucleotide binding /// catalytic activity /// binding /// ATP --- binding /// small protein activating enzyme activity /// ligase activity Dr.25297.1.A1 at -1.39511 -1.51557 -1.26189 -2.09131 1 1 1 0.9942 0.9942 ------Dr.2531.1.A1 at 1.034963 1.19579 1.421727 4.123657 1 1 1 0.180873 0.1809 fanci /// zgc:152941 Fanconi an------Dr.2531.2.S1 at 1.298999 1.398502 1.874009 2.951685 1 1 1 0.386849 0.3868 LOC560613 similar to D------Dr.25318.1.A1 at 1.846933 -1.63177 -1.83287 -2.37773 1 1 1 0.963917 0.9639 ------Dr.25319.1.A1 at -1.95777 -2.31682 -1.92196 -3.07405 1 0.910464 1 0.170541 0.1705 ------Dr.25322.1.S1 at -2.32442 -1.81448 -2.036 -2.70316 0.974 1 0.99934 0.659075 0.6591 lin7c Lin-7 homo------protein binding --- Dr.25323.1.S1 at -1.22151 -1.16638 1.087311 2.650895 1 1 1 0.528 0.528 LOC795944 similar to p ------Dr.25338.1.A1_at -1.18649 -2.60836 -2.75013 -2.47494 1 0.433 0.436541 0.733 0.433 zgc:123165 zgc:123165--- protein modification process protein-L-isoaspartate (D-aspartate) O-methyltransferase --- activity Dr.25346.1.A1 at 1.116587 2.297123 2.011462 1.774692 1 0.44 1 1 0.44 ppapdc1b phosphatid------catalytic activity membrane Dr.25347.1.A1 at 1.351432 2.018138 2.175115 2.09097 1 0.991736 0.713345 0.798363 0.7133 zgc:113421 zgc:113421------Dr.25355.1.A1 at -1.85574 -4.01203 -5.7142 -3.77815 1 0.091778 0.121396 0.205922 0.0918 zgc:153739 zgc:153739--- cell adhesion structural constituent of cell wall cytoplasm /// actin cytoskeleton Dr.25368.1.A1 x at -2.07674 -1.80293 -1.88329 -2.36311 1 1 1 0.980602 0.9806 wu:fc91f02 wu:fc91f02 ------Dr.25375.1.A1 at -1.15773 -1.1351 1.018663 2.604802 1 1 1 0.716921 0.7169 LOC553340 /// LOC79422hypothetica------Dr.25378.1.A1_at -1.55833 -1.23859 1.035749 5.426773 1 1 1 0.047393 0.0474 zgc:110540 zgc:110540--- nucleobase, nucleoside, nucleotide and nucleic acid deoxycytidine kinase activity /// ATP binding /// kinase --- metabolic process activity /// transferase activity /// phosphotransferase activity, alcohol group as acceptor Dr.25379.1.S1 at -1.65872 -2.09125 -1.53631 -2.28073 1 0.989 1 0.840281 0.8403 LOC100006782 /// LOC10similar to L ------endopeptidase inhibitor activity /// protein binding extracellular region Dr.25387.1.A1 at -4.37314 -4.13076 -6.32279 -7.0054 0.138587 0.037439 0.035172 0.02142 0.0214 wu:fj34f09 wu:fj34f09 ------Dr.2539.1.A1 at 1.681992 2.662538 4.85102 7.807148 1 0.369518 0.088421 0.021468 0.0215 wu:fy25c05 wu:fy25c05------Dr.25403.1.A1 at 1.030892 2.966104 4.628648 4.83246 1 0.454309 0.128 0.103848 0.1038 ------Dr.25405.1.A1_at -1.2562 -2.42623 -2.23784 -2.5132 1 0.984 0.997 0.954534 0.9545 sox19b SRY-box c--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity chromatin /// nucleus /// transcription factor transcription, DNA-dependent /// multicellular organismal complex development /// transcription antitermination /// positive regulation of transcription factor activity

Dr.25415.1.S1 at 2.656806 2.042819 1.910996 1.966342 0.740127 0.999 1 1 0.7401 wu:fc14a08 wu:fc14a08------Dr.25416.1.A1_at -1.62159 -1.78039 -1.33134 -2.15127 1 1 1 0.986338 0.9863 zgc:154095 zgc:154095------catalytic activity /// kinase activity /// transferase activity /// --- transferase activity, transferring phosphorus-containing groups Dr.25419.1.A1 at 1.288194 2.084062 2.242155 2.539767 1 0.999955 0.877642 0.805907 0.8059 LOC100150991 similar to U ------Dr.25420.1.S1 a at -1.58545 -2.00297 -1.42445 -2.23385 1 1 1 0.651496 0.6515 txndc5 thioredoxin --- cell redox homeostasis isomerase activity endoplasmic reticulum Dr.25421.1.S1 at -1.4954 -1.30194 -1.17159 3.000048 1 1 1 0.409236 0.4092 anln-like /// LOC562517 /// anillin, actin ------Dr.25424.1.A1 at 2.451538 3.250147 3.472001 3.468808 0.179462 0.009271 0.012605 0.036801 0.0093 im:6912504 Im:6912504------Dr.25425.1.A1 at 1.660804 2.721988 2.389929 1.705311 1 0.282216 0.726274 1 0.2822 LOC792144 hypothetica--- cell redox homeostasis --- membrane Dr.25427.1.A1 at -1.42019 -1.57377 -1.57968 -2.22529 1 1 1 0.967546 0.9675 ------Dr.2543.1.A1_at 2.594799 4.367375 4.299057 2.868912 0.495343 0.019227 0.022532 0.145258 0.0192 zgc:92586 zgc:92586 --- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm threonyl-tRNA aminoacylation /// tRNA aminoacylation threonine-tRNA ligase activity /// ATP binding /// ligase activity, forming aminoacyl-tRNA and related compounds

Dr.25436.1.S1 at -1.87277 -2.57623 -1.82087 -3.63135 1 0.602617 1 0.203747 0.2037 ------Dr.25440.1.A1 x at -1.67792 -1.831 -2.51473 -1.71848 1 1 0.454398 1 0.4544 ------Dr.25442.1.A1 at 1.186714 -2.58921 -3.98348 -2.86737 1 0.939 0.475656 0.832407 0.4757 elovl4 elongation ------integral to membrane Dr.25448.1.A1_at -1.07315 -2.05489 -2.1451 -2.04611 1 1 0.994696 0.997562 0.9947 zgc:103663 zgc:103663--- transport /// neurotransmitter transport neurotransmitter:sodium symporter activity /// gamma- integral to plasma membrane /// membrane /// aminobutyric acid:sodium symporter activity /// symporter integral to membrane activity Dr.25452.1.A1 at 2.254869 2.80717 1.831763 1.002676 0.92 0.39565 1 1 0.3956 ------Dr.25453.1.A1 at -1.68328 -2.26349 -2.63072 -2.80409 1 0.869924 0.461982 0.484711 0.462 ------Dr.25455.1.A1_at -1.12942 -1.72683 -2.22849 -1.94463 1 1 0.968307 1 0.9683 sypb synaptophy--- transport transporter activity synaptic vesicle /// membrane /// integral to membrane Dr.25458.1.S1_at 1.253005 2.358367 2.818063 3.535939 1 0.762565 0.4488 0.087967 0.088 rpl7 ribosomal p--- translation structural constituent of ribosome /// transcription regulator intracellular /// ribosome /// large ribosomal activity subunit /// ribonucleoprotein complex

Dr.25460.1.A1 at -17.9882 -22.5906 -11.4536 -24.3983 0.011407 0.010643 0.25538 0.011898 0.0106 ------Dr.25461.1.A1 at 2.503233 3.047666 2.656895 2.493823 0.328907 0.110859 0.323 0.409313 0.1109 zgc:110598 zgc:110598------methyltransferase activity /// transferase activity --- Dr.25466.1.A1 at -1.53509 -2.06345 -1.75708 -1.90328 1 0.99994 1 1 0.9999 ------Dr.25472.1.A1 at 1.820764 2.510332 2.019254 1.83198 1 0.128265 1 1 0.1283 ------Dr.25482.1.A1 at 2.490672 3.02258 2.101723 1.722186 0.62291 0.13883 0.982 1 0.1388 ------Dr.25492.1.S1_at 2.300568 1.830208 1.489529 1.19824 0.742 1 1 1 0.742 maff v-maf musc--- regulation of transcription, DNA-dependent /// regulation of DNA binding /// DNA binding /// DNA binding /// nucleus /// transcription factor complex transcription /// positive regulation of transcription, DNA- transcription factor activity /// transcription factor activity /// dependent sequence-specific DNA binding /// protein heterodimerization activity /// protein dimerization activity

Dr.25496.1.A1_at 2.74062 2.811919 3.185837 3.433953 0.511055 0.275787 0.208725 0.19032 0.1903 top1l Topoisome--- DNA topological change /// DNA unwinding during DNA binding /// DNA topoisomerase type I activity /// DNA chromosome replication topoisomerase (ATP-hydrolyzing) activity /// isomerase activity Dr.25507.1.A1 at 2.425066 3.666319 3.729814 4.997036 0.996552 0.228403 0.129611 0.056933 0.0569 eif2s2 eukaryotic t--- translational initiation translation initiation factor activity --- Dr.25519.1.S1_at 2.525864 2.396983 2.596839 2.87791 0.792 0.922644 0.777 0.537 0.537 rgl1 ral guanine --- signal transduction /// small GTPase mediated signal guanyl-nucleotide exchange factor activity intracellular transduction /// regulation of small GTPase mediated signal transduction Dr.25522.1.A1_at 2.071701 1.109772 -1.16366 -1.09906 0.994696 1 1 1 0.9947 gria2b Glutamate --- transport /// ion transport receptor activity /// ionotropic glutamate receptor activity /// membrane /// integral to membrane /// cell ion channel activity /// extracellular-glutamate-gated ion junction /// synapse /// postsynaptic membrane channel activity Dr.25527.1.A1 at -1.56991 -2.04483 -1.48938 -1.99836 1 0.992 1 0.993617 0.992 zgc:171426 zgc:171426------endopeptidase inhibitor activity /// protein binding extracellular region Dr.25527.1.A1 x at -1.89624 -2.05304 -1.47595 -1.97893 1 0.986 1 0.9997 0.986 zgc:171426 zgc:171426------endopeptidase inhibitor activity /// protein binding extracellular region Dr.25536.1.A1_at -1.25575 1.663835 1.394654 2.478933 1 1 1 0.423852 0.4239 hsp90a.2 heat shock --- protein folding /// response to stress protein binding /// ATP binding /// unfolded protein binding ---

Dr.25547.1.S1 at 2.209427 3.550239 3.745573 3.796476 0.87538 0.11808 0.158607 0.082448 0.0824 drg1 developme------GTP binding intracellular Dr.25548.1.S1 at 2.913099 4.960439 4.046656 3.059614 0.225 0.010232 0.007587 0.314912 0.0076 hsp90b1 heat shock --- protein folding /// response to stress ATP binding /// unfolded protein binding endoplasmic reticulum Dr.25549.1.S1 at 1.087506 1.877918 2.112339 2.50781 1 1 0.982587 0.676596 0.6766 LOC100003771 similar to m------Dr.25550.1.A1 at -1.1192 -2.21937 -4.4145 -3.96353 1 0.525603 0.049369 0.076094 0.0494 ------Dr.25551.1.A1 at -2.44707 -1.87132 -2.38703 -2.52251 0.623201 1 0.732 0.490377 0.4904 ------Dr.25552.2.S1 at -2.81891 -2.56652 -2.11637 -2.8367 0.097677 0.109801 0.864 0.215393 0.0977 CH211-163L21.6 hypothetica------Dr.25557.1.A1 s at 1.796209 3.494477 3.065992 2.819995 1 0.087797 0.097201 0.0626 0.0626 ------Dr.25557.1.A1 x at 1.595943 2.173925 1.770788 2.005941 1 0.99934 1 0.999917 0.9993 ------Dr.25564.1.S1_at 1.737999 2.843123 3.327872 4.339337 1 0.092157 0.02547 0.02123 0.0212 rpl7a ribosomal p--- translation /// ribosome biogenesis structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.25567.1.S1 at 1.576168 3.194359 3.523112 4.35789 1 0.071137 0.023167 0.025733 0.0232 eif3m eukaryotic t--- translation translation initiation factor activity --- Dr.25571.1.A1 at 1.240471 1.333266 1.657556 5.041902 1 1 1 0.081127 0.0811 skp2 S-phase kin--- proteolysis cysteine-type endopeptidase activity --- Dr.25578.1.A1 at 2.630779 2.807014 2.513369 2.108658 0.717421 0.602 0.685661 0.981877 0.602 zgc:153382 zgc:153382------Dr.25581.1.A1 at -1.31084 -1.26165 -1.01011 4.092442 1 1 1 0.060075 0.0601 LOC572121 similar to X ------Dr.25587.1.A1_at 1.41617 2.27326 2.116406 2.370389 1 0.913954 0.996244 0.727 0.727 tmem48 transmemb--- transport /// protein transport /// mRNA transport /// --- nucleus /// nuclear pore /// membrane /// intracellular protein transport across a membrane integral to membrane /// nuclear membrane

Dr.25590.2.A1 at 1.648478 1.591304 1.870668 2.031478 1 1 1 0.99994 0.9999 zgc:123170 zgc:123170------sequence-specific DNA binding --- Dr.25591.1.A1 at 1.464106 2.64452 3.616926 2.49205 1 0.15529 0.037095 0.182982 0.0371 si:ch211-191i18.1 si:ch211-19------integral to membrane Dr.256.1.S1_at 2.98551 4.740132 2.848055 2.308324 0.173574 0.05433 0.324331 0.504548 0.0543 sec61b SEC61, be--- transport /// protein transport /// intracellular protein P-P-bond-hydrolysis-driven protein transmembrane endoplasmic reticulum /// endoplasmic transport across a membrane transporter activity reticulum membrane /// membrane /// integral to membrane Dr.25607.1.S1_at 1.800668 2.665196 2.740036 2.617284 1 0.888257 0.403185 0.627688 0.4032 ddx21 DEAD (Asp------nucleic acid binding /// RNA binding /// helicase activity /// nucleus ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.25614.1.A1 at -4.07402 -5.21541 -5.03002 -4.06211 0.53 0.209584 0.233326 0.307642 0.2096 si:ch211-210h11.4 si:ch211-21------Dr.25615.1.A1 at 1.064803 1.31393 1.738471 3.741421 1 1 1 0.020851 0.0209 wu:fb96e11 wu:fb96e11------Dr.25631.1.S1 at -1.44894 -1.20707 1.152681 4.056674 1 1 1 0.029734 0.0297 im:6909388 im:6909388------Dr.25633.1.S1 at -1.41299 -2.3864 -2.19661 -1.97798 1 0.599926 0.980893 1 0.5999 ------Dr.25638.1.A1 at 4.312892 6.090408 4.728939 4.062529 0.077896 0.044296 0.074803 0.107731 0.0443 ------Dr.25639.1.A1 at 2.204088 1.363458 1.059399 1.000585 0.923793 1 1 1 0.9238 DKEY-258F14.5 similar to L------Dr.25642.1.A1 at 1.493589 2.036174 1.754803 1.790391 1 0.998961 1 1 0.999 eapp e2f-associa------Dr.25645.1.S1_at 1.369688 1.916027 2.009641 3.152381 1 1 1 0.139415 0.1394 zgc:175182 zgc:175182--- calcium ion transport calcium channel activity /// calcium ion binding /// calcium --- channel inhibitor activity Dr.25647.1.A1 at 1.069799 -1.46959 -1.21516 5.454154 1 1 1 0.014225 0.0142 zgc:162965 zgc:162965------Dr.25652.1.S1_at 1.009156 -1.08087 1.027212 3.877999 1 1 1 0.037095 0.0371 kntc2l kinetochore --- cell cycle /// mitosis /// cell division --- chromosome, centromeric region /// condensed chromosome kinetochore /// nucleus Dr.25657.1.A1 at 3.800427 5.140273 4.768118 7.684694 0.378 0.224443 0.281234 0.0902 0.0902 zgc:77455 zgc:77455 ------Dr.25659.1.S1 at 1.092072 1.188668 1.383773 2.511606 1 1 1 0.435 0.435 ------Dr.25663.1.S1 at 1.63124 2.861006 3.088377 4.915396 1 0.269994 0.380919 0.043337 0.0433 LOC559333 similar to s ------Dr.25672.1.A1 at 1.598458 2.286879 3.197964 2.528369 1 0.443462 0.035332 0.232049 0.0353 ------Dr.25673.1.S1_at -1.62115 -1.30106 -1.16812 5.071577 1 1 1 0.054452 0.0545 cdc25 cdc25 --- M phase of mitotic cell cycle /// protein amino acid protein tyrosine phosphatase activity intracellular dephosphorylation Dr.25673.2.S1_at -1.63941 -1.42245 -1.19382 4.18145 1 1 1 0.048163 0.0482 cdc25 Cdc25 --- M phase of mitotic cell cycle /// protein amino acid protein tyrosine phosphatase activity intracellular dephosphorylation Dr.25676.1.A1 at -1.66392 -2.95976 -3.8762 -3.38839 1 0.244324 0.042235 0.220489 0.0422 zgc:73142 zgc:73142 --- dopamine receptor signaling pathway dopamine receptor binding integral to membrane Dr.25678.2.A1 at 2.248349 3.407783 3.42734 3.032661 0.51868 0.201333 0.081378 0.167736 0.0814 rangap1 Ran GTPa--- signal transduction Ran GTPase activator activity /// protein binding --- Dr.25683.1.S1_at -1.884 -1.97699 -1.43314 -3.06716 1 1 1 0.521 0.521 ctsl1b /// im:6910535 /// LOcathepsin L--- rRNA processing /// proteolysis cysteine-type endopeptidase activity /// endopeptidase extracellular region inhibitor activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity Dr.25683.4.S1 at 2.163879 2.659807 2.12048 3.015325 0.99321 0.451802 0.999955 0.359255 0.3593 si:ch211-214j24.10 si:ch211-21------Dr.25685.1.A1 at 4.274363 2.933723 3.322953 3.86625 0.2 0.588 0.378536 0.219658 0.2 si:dkey-31f5.7 si:dkey-31f --- GMP biosynthetic process /// metabolic process catalytic activity /// IMP dehydrogenase activity --- Dr.25687.1.S1 at 1.306138 2.453272 3.204745 4.995754 1 0.936639 0.302 0.063562 0.0636 zgc:171772 zgc:171772--- translation structural constituent of ribosome intracellular /// ribosome Dr.25688.1.A1 at -2.55818 -2.19931 -2.12744 -2.19122 0.747252 0.857628 0.957841 0.879 0.7473 zgc:136936 zgc:136936--- zinc ion transport zinc ion binding /// metal ion binding --- Dr.25694.1.S1_at -1.54224 -1.93863 -1.44671 -2.28862 1 1 1 0.934 0.934 epha4a eph recepto--- protein amino acid phosphorylation /// transmembrane nucleotide binding /// protein kinase activity /// protein membrane /// integral to membrane receptor protein tyrosine kinase signaling pathway /// tyrosine kinase activity /// transmembrane receptor protein anterior/posterior pattern formation /// cell-cell recognition /// tyrosine kinase activity /// receptor activity /// ephrin receptor forebrain development activity /// ATP binding /// kinase activity /// transferase activity Dr.25702.1.A1 at -1.49909 -1.61099 -1.36829 -2.10845 1 1 1 0.995813 0.9958 zgc:66440 zgc:66440 --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.25706.1.S1_at -1.53519 -1.65672 -1.18417 -2.24626 1 1 1 0.973 0.973 wee2 WEE1 hom--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// protein tyrosine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.25709.1.A1 at 1.04703 1.728877 1.913515 2.155105 1 1 1 0.925 0.925 ------Dr.25710.1.A1 at -1.3365 -2.1012 -2.4299 -2.59795 1 0.954624 0.375756 0.479 0.3758 ------Dr.25720.1.A1_at 3.933448 4.896223 4.274179 2.816853 0.033042 0.045231 0.108586 0.207904 0.033 ddx56 DEAD (Asp------nucleic acid binding /// helicase activity /// ATP binding /// --- ATP-dependent helicase activity /// hydrolase activity

Dr.25725.1.S1 at -1.63754 -2.01033 -1.3663 -2.48815 1 1 1 0.679588 0.6796 ------Dr.25728.1.S1 at 2.043762 2.322976 2.131789 2.285517 1 0.932376 0.936639 0.772561 0.7726 zgc:65772 zgc:65772 ------nucleotide binding /// nucleic acid binding --- Dr.25729.1.S1 at -1.45397 -2.18741 -1.49732 -2.6097 1 0.984 1 0.763387 0.7634 CH211-212N6.16 /// crygmnovel prote ------Dr.25732.1.A1_at 3.381432 4.733676 3.591653 2.724896 0.056356 0.155888 0.06273 0.518286 0.0564 atad3b ATPase fam------nucleotide binding /// ATP binding /// nucleoside- --- triphosphatase activity Dr.25736.1.S1 at -1.96744 -2.17275 -1.96054 -1.38377 1 0.943 1 1 0.943 zgc:110591 zgc:110591------membrane /// integral to membrane Dr.25737.2.S1 at 1.471078 2.97885 3.590511 5.932474 1 0.48268 0.194994 0.016972 0.017 zgc:136896 zgc:136896--- translation structural constituent of ribosome intracellular /// ribosome Dr.25740.1.A1 at -2.03281 -2.4673 -2.74653 -2.8216 0.999955 0.824 0.238681 0.230229 0.2302 arl4d ADP-ribosy--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.25746.1.A1 at 2.121637 2.302142 2.193562 2.208536 0.976374 0.586 0.972 0.883 0.586 htatsf1 HIV TAT s------nucleotide binding /// nucleic acid binding --- Dr.25748.1.A1 at 1.420933 1.696915 1.763449 2.245597 1 1 1 0.784706 0.7847 ------binding --- Dr.25752.1.A1 at -2.79439 -2.95922 -3.32782 -2.45052 0.404211 0.316757 0.160142 0.651496 0.1601 zgc:112050 zgc:112050--- actomyosin structure organization and biogenesis actin binding --- Dr.25759.2.A1_a_at 2.316558 5.161853 5.316548 6.296773 0.876619 0.062591 0.077276 0.040596 0.0406 ak2 adenylate k--- nucleobase, nucleoside, nucleotide and nucleic acid adenylate kinase activity /// ATP binding /// kinase activity /// --- metabolic process transferase activity /// phosphotransferase activity, phosphate group as acceptor /// nucleotide kinase activity /// nucleobase, nucleoside, nucleotide kinase activity

Dr.25763.1.A1 at -1.4416 -1.94721 -1.3779 -2.26201 1 1 1 0.839237 0.8392 wu:fj66e11 wu:fj66e11 ------Dr.25767.1.S1 at -1.57574 -2.01921 -1.52269 -2.22535 1 1 1 0.788212 0.7882 ------Dr.25767.1.S1 x at -1.47953 -1.83229 -1.45974 -2.11603 1 1 1 0.88561 0.8856 ------Dr.25769.1.S1_at 1.636085 2.019807 1.078346 1.309385 1 0.993 1 1 0.993 hsd17b3 hydroxyster--- androgen biosynthetic process /// metabolic process /// catalytic activity /// binding /// oxidoreductase activity /// endoplasmic reticulum oxidation reduction testosterone 17-beta-dehydrogenase (NADP+) activity

Dr.2577.1.A1_at -1.00423 1.312054 2.211432 2.618192 1 1 0.983443 0.008292 0.0083 plcxd3 phosphatid --- signal transduction /// intracellular signaling cascade /// lipid phospholipase C activity /// signal transducer activity /// --- catabolic process hydrolase activity Dr.25770.1.S1_at 4.504415 4.822235 4.887693 5.039155 0.009693 0.024404 0.009666 0.00826 0.0083 ctps CTP syntha--- pyrimidine nucleotide biosynthetic process /// glutamine catalytic activity /// CTP synthase activity /// ligase activity --- metabolic process Dr.25770.4.A1 at -1.7611 -2.04346 -1.68299 -3.45339 1 0.99556 1 0.201 0.201 ------Dr.25774.1.S1 at 1.59672 1.564809 1.513871 2.628386 1 1 1 0.136844 0.1368 LOC560400 similar to n------actin binding /// calcium ion binding --- Dr.25780.1.S1 x at -1.86376 -2.03359 -1.76189 -3.20663 1 0.999955 1 0.396766 0.3968 ------Dr.25786.1.A1_at 1.012744 1.001867 1.206049 3.241294 1 1 1 0.240895 0.2409 dhfr dihydrofola--- heart morphogenesis /// glycine biosynthetic process /// dihydrofolate reductase activity /// dihydrofolate reductase --- nucleotide biosynthetic process /// oxidation reduction /// activity /// oxidoreductase activity heart contraction Dr.25798.1.A1 at 1.810268 2.547912 2.81141 3.489785 1 0.183569 0.106294 0.057931 0.0579 zgc:77052 zgc:77052 ------nucleotide binding /// nucleic acid binding --- Dr.25806.1.A1_at -1.85714 -2.18052 -1.80191 -2.11528 1 0.999917 1 0.999955 0.9999 zgc:110298 zgc:110298--- glycolysis nucleotide binding /// 6-phosphofructokinase activity /// ATP 6-phosphofructokinase complex binding /// kinase activity /// transferase activity Dr.25822.1.S1_at 2.033476 1.685144 1.377465 2.259373 1 1 1 0.998 0.998 zgc:153686 zgc:153686--- protein modification process /// metabolic process acyl-CoA dehydrogenase activity /// electron carrier activity --- /// oxidoreductase activity /// oxidoreductase activity, acting on the CH-CH group of donors /// FAD binding

Dr.25822.2.A1 at 1.680899 2.092017 2.133335 2.046181 1 0.636383 0.629 0.907435 0.629 hnrnpu Heterogene------nucleic acid binding ribonucleoprotein complex Dr.25822.3.S1 at 1.807891 2.465815 2.078383 2.110433 1 0.387 0.999955 0.977272 0.387 hnrnpu heterogene------nucleic acid binding ribonucleoprotein complex Dr.25848.1.A1 at -3.18102 -5.14942 -3.40687 -5.79622 0.391912 0.066614 0.172749 0.089459 0.0666 wu:fj12d05 wu:fj12d05 ------Dr.25850.2.A1_at 7.018614 7.377003 6.29001 4.945088 0.034395 0.036818 0.026961 0.059912 0.027 zgc:153997 zgc:153997--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.25858.1.A1 at 1.752563 2.294893 2.799156 2.787705 1 0.958523 0.798 0.575558 0.5756 wu:fc11a05 wu:fc11a05------Dr.25868.1.S1_at 1.550831 2.031631 1.851232 2.247211 1 0.999955 1 0.763 0.763 zgc:64133 zgc:64133 --- carbohydrate metabolic process /// glycolysis /// tricarboxylic catalytic activity /// binding /// oxidoreductase activity /// --- acid cycle /// malate metabolic process /// metabolic process malate dehydrogenase activity /// oxidoreductase activity, /// cellular carbohydrate metabolic process /// oxidation acting on the CH-OH group of donors, NAD or NADP as reduction acceptor /// L-malate dehydrogenase activity Dr.2587.1.S1 at 1.234386 2.274842 1.920219 1.765429 1 0.71826 1 1 0.7183 wu:fb07f12 wu:fb07f12 ------Dr.25874.1.A1 at -1.98114 -1.90126 -2.06702 -2.44285 1 1 0.999955 0.96 0.96 im:7151086 im:7151086------Dr.25878.1.S1 at -1.58719 -1.93419 -1.46167 -2.10966 1 1 1 0.988927 0.9889 ------Dr.25891.1.A1 at 9.542506 14.92182 11.76539 5.47886 0.194471 0.071353 0.095478 0.542317 0.0714 ------Dr.25904.1.A1 at -1.16203 -1.40804 -2.79952 -1.38399 1 1 0.967 1 0.967 LOC794824 similar to V ------Dr.25928.1.A1 at -1.71727 -1.88249 -2.92705 -2.64987 1 1 0.603913 0.769 0.6039 wu:fj67d03 wu:fj67d03 ------Dr.25937.1.A1 at -2.40409 -1.89641 -1.68735 -2.35203 0.99934 1 1 0.996789 0.9968 si:dkey-24p1.5 si:dkey-24p------Dr.2594.1.A1_at 2.032882 2.732068 2.704147 2.250598 0.9997 0.201 0.079104 0.651063 0.0791 ahsa1l AHA1, activ--- response to stress ATPase activator activity /// chaperone activator activity /// cytoplasm chaperone binding Dr.2596.2.A1_a_at -2.04486 -2.44741 -1.45167 -2.94631 0.999 0.522 1 0.324867 0.3249 mpv17 MpV17 tran--- nucleosome assembly DNA binding /// sugar binding nucleosome /// nucleus /// chromosome /// mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.2596.2.A1_x_at -1.53158 -1.71964 -1.24107 -2.06729 1 1 1 0.989 0.989 mpv17 MpV17 tran------mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.2596.5.A1_x_at -1.45458 -1.61651 -1.28129 -2.05173 1 1 1 0.99934 0.9993 mpv17 MpV17 tran------mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.2597.1.A1 at 1.232653 -1.32956 -1.69736 -2.62296 1 1 1 0.243 0.243 ------Dr.26000.1.A1 at -2.10637 -2.00398 -2.16445 -1.98191 0.999955 1 0.9997 0.99934 0.9993 grb10 growth fact--- signal transduction receptor activity /// protein binding --- Dr.26012.1.A1 at -1.41682 -2.11479 -1.98945 -2.46877 1 0.755 1 0.051983 0.052 ------Dr.26014.1.A1 at 1.441393 1.437845 1.321531 2.18218 1 1 1 0.866 0.866 zgc:91996 zgc:91996 --- single strand break repair damaged DNA binding intracellular /// nucleus Dr.26017.1.A1 at 1.663336 -1.96646 -2.58133 -2.26277 1 1 0.787 0.963581 0.787 ------Dr.26025.1.A1 s at 1.806463 2.64496 2.757075 2.334719 1 0.451472 0.363457 0.706337 0.3635 zgc:153192 zgc:153192------calcium ion binding --- Dr.26043.1.A1 at -3.56106 -2.53076 -6.04077 -2.03565 0.99 0.993617 0.651496 1 0.6515 ------Dr.26054.1.A1 at -1.22373 -2.1224 -2.69811 -2.58846 1 0.993 0.343811 0.426581 0.3438 ------Dr.26056.1.A1 s at -1.01921 -2.07486 -2.97893 -1.97527 1 0.990835 0.259 0.99994 0.259 ------Dr.2606.1.A1 at -1.35506 -1.71727 -2.06775 -2.00095 1 1 0.987827 0.998 0.9878 LOC568088 similar to rC------Dr.26074.1.A1 at 1.854885 2.082616 1.372895 1.161646 1 0.99934 1 1 0.9993 ------Dr.26079.1.A1 at -1.4955 -1.58524 -1.31566 -2.07285 1 1 1 0.992624 0.9926 ------Dr.26095.1.A1 at -1.6814 -2.19894 -1.31115 -2.73696 1 0.924257 1 0.413668 0.4137 ------Dr.261.1.S1_at 1.778786 2.867881 3.083756 3.090713 1 0.026477 0.029855 0.004946 0.0049 ef1a elongation f--- translation /// translational elongation nucleotide binding /// translation elongation factor activity /// cytoplasm GTPase activity /// GTP binding Dr.26102.1.A1 at -1.4444 -1.63247 -1.4371 -2.0683 1 1 1 0.98727 0.9873 ------Dr.26109.1.A1 at -1.0148 -1.48498 -2.95957 -2.60562 1 1 0.097383 0.361501 0.0974 LOC555361 similar to V------Dr.26116.1.S1_at 5.616849 8.035938 5.724937 4.56684 0.016222 0.010129 0.018736 0.055836 0.0101 hspa5 heat shock --- response to stress nucleotide binding /// ATP binding extracellular region /// endoplasmic reticulum /// endoplasmic reticulum lumen Dr.26119.2.S1_a_at -1.52504 -1.5269 -1.32436 -2.21552 1 1 1 0.991553 0.9916 slc4a2a solute carri--- transport /// anion transport /// anion transport transporter activity /// inorganic anion exchanger activity /// membrane /// integral to membrane /// anion transmembrane transporter activity /// anion exchanger basolateral plasma membrane /// apical activity /// anion exchanger activity plasma membrane Dr.26126.1.S1 at 1.032667 -1.60379 -2.02819 -1.48207 1 1 0.996557 1 0.9966 wipi1 WD repeat ------acid phosphatase activity --- Dr.26138.1.A1 at 2.990453 5.184209 5.142799 5.560096 0.440266 0.050137 0.037189 0.035846 0.0358 ------Dr.26139.1.A1_at 1.034784 1.941689 1.365523 2.158866 1 0.999955 1 0.995 0.995 slc25a14 Hypothetica--- transport /// mitochondrial transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.26139.1.A1_x_at 1.090124 2.198369 1.639728 2.315425 1 0.991918 1 0.962505 0.9625 slc25a14 Hypothetica--- transport /// mitochondrial transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.2615.1.S1 at -1.46268 -2.13915 -2.36167 -1.92732 1 0.918319 0.427695 1 0.4277 appb amyloid bet------serine-type endopeptidase inhibitor activity /// binding integral to membrane Dr.26154.1.A1 at -1.56506 -1.9258 -1.68682 -2.25192 1 1 1 0.962 0.962 ------Dr.26154.1.A1 x at -1.46149 -1.58956 -1.43352 -2.19791 1 1 1 0.952 0.952 ------Dr.26169.1.A1 at -2.43321 -3.88596 -3.1769 -4.87449 0.872 0.264 0.474 0.103631 0.1036 ------Dr.2618.1.A1 at 1.196712 1.379758 1.312814 2.402202 1 1 1 0.642531 0.6425 btbd10b BTB (POZ ------Dr.26189.1.A1 at -1.6858 -1.82992 -1.38481 -2.20562 1 1 1 0.915606 0.9156 ------Dr.2619.1.S1 at -1.28058 1.781934 2.077229 1.592415 1 1 0.98838 1 0.9884 rbmx RNA bindin------nucleotide binding /// nucleic acid binding --- Dr.2620.1.A1 at 4.108237 6.269249 8.20041 8.582092 0.041078 0.028878 0.014871 0.010117 0.0101 LOC553336 hypothetica------Dr.26209.1.A1 at -1.09371 -1.60527 -1.34272 -2.15576 1 1 1 0.896215 0.8962 zgc:152753 zgc:152753------GTP binding --- Dr.2625.1.A1 at -3.28775 -1.87963 -2.57189 -2.806 0.666453 1 0.969 0.785 0.6665 LOC561403 similar to d ------Dr.26258.1.A1 at -1.04264 1.082282 1.200299 5.465432 1 1 1 0.025234 0.0252 ------Dr.26261.1.A1 s at 3.593515 3.048443 2.545537 1.78835 0.093847 0.093773 0.159043 1 0.0938 ------Dr.26262.1.A1 at 2.245891 6.346489 4.122603 3.574913 0.906 0.091842 0.036656 0.3724 0.0367 LOC556413 similar to G------Dr.26267.1.A1 at 1.059603 -1.5307 -2.13338 -1.47359 1 1 0.998 1 0.998 ------Dr.26271.1.A1_at -1.8845 -2.41249 -2.93241 -2.3625 1 0.889 0.456256 0.912756 0.4563 LOC572779 /// zgc:77182 similar to p --- nucleobase, nucleoside, nucleotide and nucleic acid purine-nucleoside phosphorylase activity /// transferase --- metabolic process activity /// transferase activity, transferring glycosyl groups /// transferase activity, transferring pentosyl groups

Dr.26272.1.A1 at 1.934828 2.418554 6.084357 6.863154 1 0.565295 0.025229 0.007274 0.0073 ------Dr.26289.1.A1_at 3.202942 10.33791 7.525974 9.445395 0.781 0.017896 0.019161 0.015481 0.0155 zgc:112285 zgc:112285--- proteolysis catalytic activity /// serine-type endopeptidase activity /// --- endopeptidase inhibitor activity /// peptidase activity /// hydrolase activity Dr.26301.1.A1 at -1.82078 -2.23688 -2.45188 -2.32888 1 0.666265 0.313691 0.581124 0.3137 LOC571265 similar to p------Dr.26303.1.A1 at 2.136871 2.359948 1.787249 2.124499 0.995 0.972478 1 0.99994 0.9725 ------Dr.26315.1.A1 at -1.39015 -1.68818 -1.48833 -2.10325 1 1 1 0.998 0.998 ------Dr.26322.1.A1 at 1.995759 3.470018 3.934695 4.353529 1 0.096953 0.076953 0.045675 0.0457 pa2g4a Proliferation--- proteolysis metalloexopeptidase activity --- Dr.26332.1.A1 s at -1.12056 1.370498 1.963049 2.812533 1 1 1 0.409861 0.4099 wu:fa04d04 wu:fa04d04------Dr.26333.1.A1 at 2.143129 1.682122 1.892138 2.219173 0.941454 1 1 0.806 0.806 brd2a bromodoma------Dr.26336.1.A1_at 1.602717 1.841777 1.980874 2.007125 1 1 1 0.99994 0.9999 zgc:153452 zgc:153452--- mRNA processing /// RNA splicing /// RNA metabolic RNA binding /// binding /// protein binding nucleus /// spliceosome process Dr.26337.1.A1 at -1.23992 1.043214 -1.00566 7.87054 1 1 1 0.040555 0.0406 cdc20 cell division --- cell division ------Dr.2634.1.A1_at 2.121284 1.171472 -1.09524 -1.184 0.89 1 1 1 0.89 si:ch211-142e24.2 si:ch211-14--- metabolic process nucleic acid binding /// catalytic activity /// endonuclease --- activity Dr.26342.2.S1 at -2.44945 -2.7378 -3.49427 -2.73954 0.978177 0.748981 0.245415 0.518465 0.2454 si:ch211-210h11.4 Si:ch211-2 ------Dr.26353.1.A1_at 1.605692 2.011779 1.601522 1.549224 1 0.99934 1 1 0.9993 zgc:172295 Zgc:17229 --- carbohydrate metabolic process /// glycerol-3-phosphate glycerol kinase activity /// kinase activity /// transferase --- metabolic process activity Dr.26354.1.A1 at -1.53248 -1.7286 -4.12674 -3.25149 1 1 0.661 0.987219 0.661 wu:fb78c05 wu:fb78c05------Dr.2636.1.S1 at 2.721084 3.567669 3.339105 1.853823 0.334582 0.243497 0.086182 1 0.0862 impdh2 IMP (inosin--- GMP biosynthetic process /// metabolic process catalytic activity /// IMP dehydrogenase activity --- Dr.26361.1.A1 at 3.223119 3.327396 2.751462 3.457883 0.163 0.209871 0.586866 0.07697 0.077 LOC554429 /// zgc:66427 hypothetica--- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.2637.1.S1_at 1.010764 1.156546 1.889588 3.056522 1 1 1 0.271572 0.2716 msh2 mutS homo--- mismatch repair /// mismatch repair DNA binding /// ATP binding /// mismatched DNA binding /// MutSalpha complex /// MutSbeta complex guanine/thymine mispair binding /// guanine/thymine mispair binding Dr.26370.1.S1 at 3.803465 4.436197 5.168364 5.082518 0.169688 0.052613 0.023811 0.049352 0.0238 LOC563247 similar to ri--- translation structural constituent of ribosome intracellular /// ribosome Dr.26377.1.A1 at 2.834104 3.403994 2.82733 2.926746 0.447 0.296523 0.593209 0.377369 0.2965 zgc:100927 zgc:100927------nucleotide binding --- Dr.26379.1.A1 at -1.25658 -1.57832 -3.43222 -2.34254 1 1 0.20545 0.605936 0.2055 ------Dr.26382.1.A1 at -1.46425 -2.22287 -1.84599 -2.61578 1 0.965 1 0.572886 0.5729 zgc:158667 Zgc:158392--- coenzyme A biosynthetic process pantothenate kinase activity /// ATP binding --- Dr.26384.1.A1 at 4.215016 1.30276 1.891059 2.400309 0.501 1 1 0.976 0.501 wu:fc48a01 wu:fc48a01------Dr.26392.1.A1_at 2.274064 2.410191 2.180009 1.850151 0.464753 0.268559 0.519723 1 0.2686 sdc4l syndecan 4 --- cell adhesion /// negative regulation of signal transduction cytoskeletal protein binding signal recognition particle, endoplasmic reticulum targeting /// membrane Dr.26394.1.A1 at -1.13153 -1.42754 -2.45527 -2.09724 1 1 0.09638 0.984 0.0964 ------Dr.26398.2.S1 at -1.33617 -2.57141 -2.41086 -2.75246 1 0.831599 0.895 0.7603 0.7603 wu:fb77e12 wu:fb77e12------Dr.26398.3.A1 at 1.598609 -1.63907 -2.11607 -2.34964 1 1 0.949 0.867384 0.8674 wu:fb77e12 wu:fb77e12------Dr.26402.1.S1 at -1.14827 -1.08694 -1.06759 2.501066 1 1 1 0.937282 0.9373 lbr Lamin B re --- cell migration involved in gastrulation receptor activity nuclear inner membrane /// membrane Dr.26404.3.S1 at -1.33292 -1.06915 1.131956 9.141366 1 1 1 0.06251 0.0625 LOC564072 similar to T------Dr.26405.1.S1_at 4.82204 6.585046 6.348128 4.222518 0.050468 0.024718 0.051115 0.063 0.0247 sdc4l syndecan 4 --- cell adhesion /// negative regulation of signal transduction cytoskeletal protein binding signal recognition particle, endoplasmic reticulum targeting /// membrane Dr.26410.1.S1 at 3.347632 5.502269 4.742753 3.798438 0.092259 0.026622 0.035332 0.073892 0.0266 zgc:114204 zgc:114204--- vesicle-mediated transport ------Dr.26416.1.A1_at 2.323111 3.96798 3.774373 3.319553 0.957807 0.153461 0.11808 0.163615 0.1181 aars alanyl-tRNA--- translation /// alanyl-tRNA aminoacylation /// tRNA nucleic acid binding /// aminoacyl-tRNA ligase activity /// cytoplasm aminoacylation alanine-tRNA ligase activity /// ATP binding /// ligase activity, forming aminoacyl-tRNA and related compounds

Dr.26417.1.A1_at 1.096351 1.544844 1.729628 2.437843 1 1 1 0.506276 0.5063 zgc:158138 zgc:158138--- fatty acid metabolic process /// fatty acid beta-oxidation /// catalytic activity /// 3-hydroxyacyl-CoA dehydrogenase mitochondrion /// fatty acid beta-oxidation metabolic process activity /// enoyl-CoA hydratase activity /// binding /// multienzyme complex oxidoreductase activity /// coenzyme binding Dr.26419.1.A1 at 1.344339 -1.58881 -2.20516 -1.80118 1 1 0.823 1 0.823 wu:fc70h04 wu:fc70h04------Dr.2642.2.A1 at 1.750317 2.614819 2.783648 3.816466 1 0.202466 0.448199 0.038814 0.0388 zgc:101555 zgc:101555--- transport --- intracellular Dr.26422.1.A1_at 3.588819 3.569371 4.687213 4.321946 0.108142 0.059435 0.017206 0.01756 0.0172 cnn2 calponin 2 --- actomyosin structure organization and biogenesis /// actin binding --- regulation of MAPKKK cascade /// regulation of blood vessel endothelial cell migration Dr.26430.1.A1 at 2.453472 2.628485 2.836958 2.258273 0.19032 0.079778 0.142824 0.6773 0.0798 rcc1 regulator of ------Dr.26432.1.A1 at -1.63288 -1.78931 -1.49237 -2.20165 1 1 1 0.99156 0.9916 ------Dr.2644.1.A1 at 2.190261 -1.02085 1.284934 1.017256 0.973237 1 1 1 0.9732 dhrs3 dehydrogen--- metabolic process /// oxidation reduction catalytic activity /// binding /// oxidoreductase activity --- Dr.26446.1.S1_at -1.84223 -2.83194 -2.70485 -2.76585 1 0.663222 0.757387 0.79 0.6632 chrnb3a cholinergic --- transport /// ion transport receptor activity /// nicotinic acetylcholine-activated cation- membrane /// integral to membrane /// cell selective channel activity /// ion channel activity /// junction /// synapse /// postsynaptic membrane extracellular ligand-gated ion channel activity /// neurotransmitter receptor activity Dr.26450.1.S1_at -1.79112 -2.07261 -1.59846 -2.23453 1 0.997562 1 0.940461 0.9405 vegfc vascular en--- angiogenesis /// angiogenesis /// lymphangiogenesis /// vascular endothelial growth factor receptor binding /// growth membrane lymphangiogenesis /// endoderm development /// cell factor activity proliferation Dr.26453.1.S1_at -1.47893 -1.22508 1.172145 2.304079 1 1 1 0.941454 0.9415 zgc:64116 zgc:64116 --- cell cycle /// mitosis --- chromosome, centromeric region /// nucleus

Dr.26461.1.S1_at -1.15563 1.671677 2.528806 2.755266 1 1 0.764 0.142305 0.1423 zgc:63947 zgc:63947 --- GPI anchor biosynthetic process --- proteinaceous extracellular matrix /// plasma membrane /// membrane /// anchored to membrane Dr.26465.1.S1 at -1.15241 -1.63591 -2.48587 -1.9513 1 1 0.462424 1 0.4624 rnf11 ring finger --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.26471.1.S1 at 1.393538 2.115654 1.65857 1.601571 1 0.947794 1 1 0.9478 zgc:64148 zgc:64148 ------Dr.26483.1.S1_at -1.00507 2.322544 2.078287 1.768312 1 0.847274 0.999955 1 0.8473 ero1l ERO1-like --- protein thiol-disulfide exchange protein binding /// electron carrier activity /// oxidoreductase endoplasmic reticulum membrane activity, acting on sulfur group of donors, disulfide as acceptor /// FAD binding Dr.26485.1.S1_at -1.71702 -1.89341 -1.49802 -2.01474 1 1 1 0.99994 0.9999 slc25a27 solute carri--- transport /// mitochondrial transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.26489.1.A1 at 1.246796 1.815437 2.33839 2.558422 1 1 0.848396 0.513784 0.5138 sb:cb346 sb:cb346 ------Dr.26496.1.S1_at -1.95499 -2.22466 -2.53313 -2.36444 1 0.958085 0.290467 0.81731 0.2905 gpsn2 glycoprotei--- lipid metabolic process oxidoreductase activity, acting on the CH-CH group of cytoplasm /// integral to membrane donors Dr.26507.1.A1 at -2.11617 -1.22378 -1.02545 1.39908 0.99934 1 1 1 0.9993 LOC562946 similar to p------Dr.26511.1.S1 at 1.50515 2.325476 2.888176 3.039892 1 0.876882 0.0861 0.080157 0.0802 zgc:136591 zgc:136591--- translation structural constituent of ribosome intracellular /// ribosome Dr.26512.1.A1 at 2.87423 4.388344 3.950288 3.323504 0.38466 0.083018 0.098296 0.172624 0.083 wu:fa93c10 wu:fa93c10------Dr.26513.1.S1_at 1.553844 2.417329 2.934278 3.13049 1 0.582776 0.354354 0.270608 0.2706 zgc:110154 zgc:110154--- translation /// translational initiation /// transport RNA binding /// translation initiation factor activity /// cytoplasm transporter activity /// binding Dr.26516.1.S1 at -1.58739 -2.04907 -1.44016 -2.25737 1 0.999955 1 0.934734 0.9347 ------Dr.26526.1.S1 at 1.536773 2.607956 2.306941 2.209181 1 0.20295 0.330393 0.642 0.203 vbp1 von Hippel---- protein folding unfolded protein binding prefoldin complex Dr.26532.1.A1 at 1.04947 1.561408 2.007888 2.258846 1 1 1 0.966 0.966 zgc:101819 zgc:101819------Dr.26534.1.A1 at -1.26231 -2.17732 -2.73567 -2.85501 1 0.94396 0.170423 0.155894 0.1559 ------Dr.2654.1.A1_at 1.3732 1.640892 1.621332 3.637183 1 1 1 0.091549 0.0915 rfx2 regulatory f--- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription regulator activity nucleus transcription Dr.26546.1.A1_at -1.09209 -1.05424 1.424598 4.012001 1 1 1 0.206697 0.2067 hells helicase, ly ------nucleic acid binding /// DNA binding /// helicase activity /// --- ATP binding Dr.266.1.S1_at -2.03498 -1.97945 -1.81975 -2.41641 1 1 1 0.941 0.941 mef2a myocyte en--- somitogenesis /// transcription /// transcription termination /// rhodopsin-like receptor activity /// DNA binding /// nucleus /// integral to membrane regulation of transcription, DNA-dependent /// G-protein transcription factor activity /// sequence-specific DNA coupled receptor protein signaling pathway /// heart binding development /// myofibril assembly /// transcription antitermination Dr.2668.1.S1_at 1.44628 2.535379 2.463285 1.833957 1 0.75 0.537336 1 0.5373 cad carbamoyl---- 'de novo' pyrimidine base biosynthetic process /// 'de novo' catalytic activity /// aspartate carbamoyltransferase activity /// endoplasmic reticulum pyrimidine base biosynthetic process /// amino acid carbamoyl-phosphate synthase activity /// ATP binding /// metabolic process /// glutamine metabolic process /// amino acid binding /// carboxyl- or carbamoyltransferase nitrogen compound metabolic process /// metabolic process activity /// hydrolase activity /// hydrolase activity, acting on /// biosynthetic process carbon-nitrogen (but not peptide) bonds /// hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Dr.2668.2.A1_at 5.304058 7.122558 6.271566 4.063739 0.013617 0.023678 0.017363 0.05597 0.0136 cad carbamoyl---- 'de novo' pyrimidine base biosynthetic process /// 'de novo' catalytic activity /// aspartate carbamoyltransferase activity /// endoplasmic reticulum pyrimidine base biosynthetic process /// amino acid carbamoyl-phosphate synthase activity /// ATP binding /// metabolic process /// glutamine metabolic process /// amino acid binding /// carboxyl- or carbamoyltransferase nitrogen compound metabolic process /// metabolic process activity /// hydrolase activity /// hydrolase activity, acting on /// biosynthetic process carbon-nitrogen (but not peptide) bonds /// hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Dr.2677.1.S1 at -1.51999 2.457524 1.462267 1.192952 1 0.864358 1 1 0.8644 ------Dr.2703.1.A1 at 2.155047 2.169515 1.508157 1.813519 0.942804 0.970422 1 1 0.9428 wu:fc45d03 wu:fc45d03------Dr.2704.1.A1 at -2.0933 -2.42635 -2.41265 -2.15937 0.996879 0.801 0.869443 0.985921 0.801 wu:fc45e01 wu:fc45e01------Dr.2722.1.A1 at 1.056193 1.295067 1.397632 2.216877 1 1 1 0.850713 0.8507 ------Dr.2724.2.A1_at 1.895574 2.701426 2.609852 2.350188 1 0.214321 0.413712 0.520812 0.2143 sip1 survival of m--- spliceosome assembly /// nuclear mRNA splicing, via ------spliceosome /// axon extension involved in development

Dr.2726.1.S1_at 2.10024 1.863266 1.562128 1.381475 0.996511 1 1 1 0.9965 zgc:55661 zgc:55661 --- ubiquitin-dependent protein catabolic process ubiquitin thiolesterase activity /// endopeptidase inhibitor --- activity /// peptidase activity /// cysteine-type peptidase activity /// zinc ion binding /// hydrolase activity

Dr.2730.1.S1 at -1.04796 1.460845 1.72136 2.27997 1 1 1 0.768419 0.7684 rabif RAB intera--- small GTPase mediated signal transduction guanyl-nucleotide exchange factor activity --- Dr.2741.1.S1_at 1.669761 2.77745 3.421678 3.980003 1 0.147069 0.040136 0.033602 0.0336 rbb4 retinoblasto--- DNA replication /// chromatin remodeling /// transcription /// DNA-dependent ATPase activity nucleus /// nucleus transcription termination /// regulation of transcription, DNA- dependent /// cell cycle /// chromatin modification /// transcription antitermination Dr.275.1.S1_at 2.08513 1.682389 1.413086 1.276807 0.998 1 1 1 0.998 jak1 Janus kina--- protein amino acid phosphorylation /// proteolysis /// nucleotide binding /// protein kinase activity /// protein cytoskeleton /// endomembrane system /// multicellular organismal development tyrosine kinase activity /// non-membrane spanning protein membrane tyrosine kinase activity /// Janus kinase activity /// protein binding /// ATP binding /// metallopeptidase activity /// zinc ion binding /// kinase activity /// transferase activity

Dr.2764.1.S1 at -1.74388 -2.72465 -1.93706 -2.6702 1 0.397307 1 0.628 0.3973 wu:fc44h08 wu:fc44h08------Dr.2765.1.A1 at 1.998942 2.530009 2.417471 2.671394 1 0.675 0.865 0.670811 0.6708 ciapin1 cytokine ind------Dr.2785.1.A1 at 1.540274 2.328166 1.838795 1.287574 1 0.824763 1 1 0.8248 LOC402879 hypothetica------Dr.2788.1.S1 at 2.917969 4.553642 4.013771 3.09746 0.437913 0.080108 0.105437 0.262 0.0801 si:dkeyp-86b9.2 si:dkeyp-86--- vesicle-mediated transport --- integral to membrane Dr.2798.1.A1 at -2.09709 -2.45815 -3.02911 -2.18968 0.997322 0.77822 0.302 0.985798 0.302 wu:fc87e07 wu:fc87e07------Dr.280.2.S1_at 1.427006 2.360941 3.062842 3.909151 1 0.944529 0.085159 0.051115 0.0511 rps20 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit Dr.2813.1.S1_at -1.52724 -1.32397 -1.01256 3.230909 1 1 1 0.133 0.133 zgc:55461 zgc:55461 --- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.2817.1.A1 at 3.107361 3.006641 2.639885 2.215209 0.167736 0.375351 0.643213 0.96 0.1677 sestd1 SEC14 and --- blood vessel morphogenesis ------Dr.2818.1.A1 at 2.025063 2.19393 1.364535 1.235909 0.996712 0.985207 1 1 0.9852 zgc:91986 zgc:91986 --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding intracellular Dr.282.1.S1 at 2.75049 4.588448 4.550912 3.864731 0.824344 0.297386 0.336271 0.410746 0.2974 LOC100003367 /// nol5 similar to N------Dr.2820.1.S1 at 2.063935 2.384783 2.17578 2.043445 0.988 0.815572 0.983688 0.998 0.8156 zmynd19 zinc finger, ------zinc ion binding --- Dr.2832.1.A1 at 1.771811 2.305778 2.532397 1.734758 1 0.987625 0.104977 1 0.105 LOC564287 similar to C------Dr.2833.1.A1 at -1.13813 -1.03969 -1.09587 5.476336 1 1 1 0.117968 0.118 si:ch211-69g19.2 si:ch211-69------Dr.284.3.S1_a_at 1.162592 1.75697 1.81041 2.173981 1 1 1 0.560528 0.5605 rpl6 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.2850.1.S1_at 2.296992 2.735824 1.597306 1.301505 0.887394 0.587758 1 1 0.5878 mat2a methionine --- one-carbon compound metabolic process methionine adenosyltransferase activity /// ATP binding /// --- transferase activity Dr.2863.1.A1_at 3.165568 3.173981 2.6475 2.60179 0.053459 0.048526 0.25587 0.108586 0.0485 slc25a25 solute carri--- transport /// calcium ion transport transporter activity /// calcium channel activity /// binding /// mitochondrion /// mitochondrial inner calcium ion binding /// calcium channel inhibitor activity membrane /// membrane /// integral to membrane Dr.2876.1.A1_at 1.80738 2.301203 2.081975 2.068602 1 0.73037 0.999955 0.996927 0.7304 zgc:101532 zgc:101532------nucleotide binding /// nucleic acid binding /// translation --- initiation factor activity Dr.2883.1.A1_at -1.15628 -1.13045 1.745536 4.02213 1 1 1 0.071271 0.0713 dnmt7 DNA (cytos--- DNA methylation /// DNA methylation DNA binding /// calcium ion binding /// methyltransferase --- activity /// zinc ion binding /// transferase activity

Dr.2884.1.S1 at -1.58535 -1.53425 -1.81657 -2.11319 1 1 1 0.990835 0.9908 ------Dr.2885.1.S1 at 1.691791 2.15406 1.758674 1.50564 1 0.833647 1 1 0.8336 ftsj1 FtsJ homol------Dr.2891.1.S1 at 1.227324 1.818081 2.178639 1.781014 1 1 0.817364 1 0.8174 wu:fb10b08 wu:fb10b08------Dr.2896.1.S1_at 1.712616 2.071369 1.952813 1.601365 1 0.997322 1 1 0.9973 prps1a phosphorib--- nucleoside metabolic process /// ribonucleoside magnesium ion binding /// ribose phosphate --- monophosphate biosynthetic process /// nucleotide diphosphokinase activity /// kinase activity /// metal ion biosynthetic process /// cellular biosynthetic process binding Dr.29.1.S1 at 1.506424 1.583806 2.853873 4.156841 1 1 0.282708 0.112144 0.1121 ccne cyclin E --- cell cycle /// cell division kinase activity nucleus Dr.2912.1.A1 at -1.2002 -1.5064 -2.07549 -1.88447 1 1 0.908269 1 0.9083 si:dkey-13i19.1 si:dkey-13i ------kinase activity --- Dr.2919.1.S1 at -1.10236 1.074035 1.293635 3.917141 1 1 1 0.076864 0.0769 wu:fb40b03 wu:fb40b03------Dr.2920.1.A1 at -2.1099 -2.0516 -2.22977 -2.20134 0.904713 0.998 0.667804 0.852348 0.6678 LOC563749 similar to z------Dr.2933.1.A1 at -1.4945 -1.7529 -2.57141 -3.12871 1 1 0.499417 0.046831 0.0468 laptm4a lysosomal-a------integral to membrane Dr.2945.2.A1 at 1.041329 2.046773 1.6598 1.983581 1 0.98838 1 1 0.9884 wu:fe18e04 wu:fe18e04------Dr.296.1.S1_at -1.09713 -1.61614 -2.6127 -2.28148 1 1 0.098296 0.626499 0.0983 ckb creatine kin------catalytic activity /// creatine kinase activity /// kinase activity --- /// transferase activity /// transferase activity, transferring phosphorus-containing groups Dr.2961.1.S1_at -1.91681 -2.72561 -2.59239 -1.8159 1 0.50427 0.247737 1 0.2477 rdh1l retinol dehy--- skeletal development /// metabolic process /// exocrine catalytic activity /// retinol dehydrogenase activity /// binding --- pancreas development /// pectoral fin morphogenesis /// /// oxidoreductase activity retinol metabolic process /// retinal metabolic process /// gut morphogenesis /// oxidation reduction

Dr.297.1.S1_at 1.658352 3.857918 3.11485 2.105043 1 0.038662 0.37192 0.899446 0.0387 ssr3 signal sequ--- cotranslational protein targeting to membrane receptor activity translocon complex /// integral to endoplasmic reticulum membrane Dr.2979.1.S1 at 1.55362 2.152733 2.485212 3.340611 1 0.890401 0.090672 0.01703 0.017 ndufa4l NADH deh--- ubiquinone biosynthetic process ------Dr.2993.1.A1 at 2.037657 -1.09981 -1.06541 -1.19872 0.994295 1 1 1 0.9943 zgc:123214 zgc:123214--- regulation of transcription transcription regulator activity nucleus Dr.2995.1.A1 at 1.597698 2.004479 2.098802 2.406968 1 0.99994 1 0.818909 0.8189 wu:fb77f12 wu:fb77f12 ------Dr.2999.1.S1 at -1.04329 1.006147 1.011935 2.155045 1 1 1 0.955495 0.9555 wu:fk86b08 wu:fk86b08------Dr.2999.2.S1_at -1.50321 -1.075 -2.06788 -1.22513 1 1 0.998 1 0.998 amd1 Hypothetica--- spermine biosynthetic process /// spermidine biosynthetic adenosylmethionine decarboxylase activity --- process Dr.3.1.S1_at -3.11484 -2.96883 -3.24191 -3.13804 0.643224 0.574643 0.399437 0.480893 0.3994 atp1b3a ATPase, N--- transport /// ion transport /// potassium ion transport /// sodium:potassium-exchanging ATPase activity membrane /// integral to membrane sodium ion transport Dr.3000.1.A1 at -1.33925 -3.99933 -4.48188 -3.28829 1 0.024404 0.040894 0.386 0.0244 wu:fb66g08 wu:fb66g08------Dr.3005.1.A1 at 1.300384 2.501616 2.099296 1.526352 1 0.230537 0.991278 1 0.2305 alg5 asparagine------Dr.301.1.S1 at 1.367342 1.312182 1.404944 2.390021 1 1 1 0.961855 0.9619 LOC799355 hypothetica------Dr.3015.1.A1 at 1.523452 2.148931 1.900694 2.3193 1 0.997 1 0.952775 0.9528 si:ch211-203h15.3 si:ch211-20------integral to membrane Dr.3017.1.A1 at -1.66173 -4.17648 -3.92333 -3.25524 1 0.081187 0.149376 0.175373 0.0812 wu:fb80f02 wu:fb80f02 ------Dr.3033.2.A1 at 1.971697 2.867162 2.34692 2.693013 0.997322 0.183488 0.932376 0.40819 0.1835 wu:fa01h10 wu:fa01h10------Dr.3033.2.A1 x at 1.8109 2.283599 2.17175 2.174222 1 0.080739 0.828533 0.431742 0.0807 wu:fa01h10 wu:fa01h10------Dr.3054.1.A1_at 1.451554 2.31842 2.570567 2.632515 1 0.644 0.711513 0.309602 0.3096 psmc4 proteasome --- protein catabolic process nucleotide binding /// ATP binding /// hydrolase activity /// nucleus /// cytoplasm /// cytosol /// protein nucleoside-triphosphatase activity complex Dr.3058.1.A1 at -1.08486 -1.13101 1.080642 2.248339 1 1 1 0.739355 0.7394 zgc:153910 zgc:153910------Dr.3061.1.A1 at 1.016704 -1.29831 -2.0906 -1.30027 1 1 0.969 1 0.969 wu:fj44b09 wu:fj44b09 ------Dr.3063.1.S1 at 1.520261 2.701939 3.072831 2.932931 1 0.63608 0.397826 0.5734 0.3978 wu:fb76c12 wu:fb76c12------Dr.3074.1.A1 at -3.1001 -2.89302 -3.01259 -2.89935 0.069363 0.40819 0.132513 0.135712 0.0694 zgc:77395 zgc:77395 ------DNA binding /// sequence-specific DNA binding intracellular Dr.3075.1.S1 at 1.863091 2.493221 2.536833 2.108336 1 0.766 0.879693 0.997 0.766 tomm34 translocase ------binding --- Dr.3076.1.A1_a_at -1.83942 -2.29536 -1.69297 -1.03367 1 0.924 1 1 0.924 wu:fc51g12 wu:fc51g12--- microtubule-based movement nucleotide binding /// motor activity /// microtubule motor microtubule /// microtubule associated activity /// ATP binding complex Dr.3096.1.A1_at 1.906737 2.492917 2.197671 1.597908 1 0.127091 0.955 1 0.1271 timm17a translocase --- intracellular protein transport /// protein transport protein transporter activity /// P-P-bond-hydrolysis-driven mitochondrial inner membrane /// protein transmembrane transporter activity mitochondrial inner membrane presequence translocase complex Dr.3103.1.S1_at 1.360914 2.320299 2.795663 3.107737 1 0.485553 0.119167 0.076869 0.0769 psmd1 proteasome --- regulation of protein catabolic process binding /// enzyme regulator activity proteasome complex /// cytosol /// protein complex Dr.3118.1.A1_a_at -1.25071 -1.18363 1.525036 2.991796 1 1 1 0.15 0.15 dnmt5 DNA (cytos--- DNA methylation DNA binding /// protein binding /// methyltransferase activity --- /// zinc ion binding /// transferase activity Dr.3129.1.A1 at -1.30441 -1.18936 -1.01901 3.161039 1 1 1 0.206187 0.2062 zgc:152925 zgc:152925------Dr.3131.1.S1_at 1.679322 3.220366 3.463809 4.697339 1 0.058334 0.008958 0.015732 0.009 rps8 ribosomal p------intracellular /// ribosome /// ribonucleoprotein complex Dr.314.1.S1_at 3.212784 7.001658 16.98641 25.41324 0.359573 0.024603 0.009802 0.007992 0.008 ascl1a achaete-sc--- epithelial cell maturation /// transcription /// transcription DNA binding /// transcription regulator activity nucleus /// nucleus termination /// regulation of transcription, DNA-dependent /// multicellular organismal development /// nervous system development /// nervous system development /// nervous system development /// hindbrain morphogenesis /// hindbrain morphogenesis /// adenohypophysis development /// cell differentiation /// transcription antitermination /// regulation of transcription

Dr.3143.1.S1_at 1.020781 1.662024 2.169812 2.210313 1 1 0.970412 0.883 0.883 psmc3 proteasome --- protein catabolic process nucleotide binding /// ATP binding /// hydrolase activity /// nucleus /// cytoplasm /// cytosol /// protein nucleoside-triphosphatase activity complex Dr.3153.1.A1 at -1.12129 1.029659 1.50576 3.966012 1 1 1 0.163615 0.1636 zgc:109978 zgc:109978------calmodulin binding --- Dr.3166.1.A1 at 2.261645 2.817835 2.591102 3.604423 0.985 0.707497 0.961 0.360932 0.3609 wu:fc43e12 Wu:fc43e1 ------Dr.3168.2.A1_a_at 1.807498 2.105555 2.241352 1.989716 1 0.996879 0.992731 0.999955 0.9927 snupn snurportin --- protein import into nucleus /// intracellular protein transport protein transporter activity nucleus /// nuclear pore /// cytoplasm

Dr.3170.1.A1 at 2.366329 1.684452 1.638311 2.351059 0.704255 1 1 0.667898 0.6679 tmem35 transmemb------Dr.3179.1.A1 at -1.03377 1.228267 1.224607 17.15997 1 1 1 0.004634 0.0046 tacc3 transformin------Dr.3198.1.S1 at 1.515237 2.762406 3.097687 3.424827 1 0.036178 0.173792 0.060841 0.0362 zgc:55768 zgc:55768 ------GTP binding intracellular Dr.321.1.S1_at 1.343825 2.100089 2.288962 2.420219 1 0.888517 0.702292 0.180204 0.1802 ran ras-related --- transport /// intracellular protein transport /// nucleotide binding /// GTPase activity /// protein binding /// nucleus nucleocytoplasmic transport /// signal transduction /// small GTP binding GTPase mediated signal transduction /// protein transport

Dr.322.2.A1 a at -4.04279 -3.16446 -3.39175 -3.59969 0.370327 0.746066 0.563275 0.474423 0.3703 ------Dr.3237.1.A1 at 1.24785 1.87431 1.674988 2.024454 1 1 1 0.9997 0.9997 wu:fc08b04 wu:fc08b04------Dr.3238.1.A1 at -1.08502 -2.97183 -3.63022 -2.98292 1 0.354354 0.086453 0.389583 0.0865 klf11a Kruppel-like------nucleic acid binding /// zinc ion binding intracellular Dr.3255.1.A1 at 1.114022 -1.67905 -3.57724 -2.39964 1 1 0.145783 0.986 0.1458 ------Dr.3262.1.S1 at 1.889171 2.405656 2.20984 2.466245 1 0.958901 0.670139 0.09638 0.0964 utp15 utp15, U3 s--- rRNA processing --- nucleus Dr.3275.1.A1_at -2.2762 -3.96215 -5.13663 -3.00943 0.949741 0.168626 0.080157 0.304239 0.0802 gpd1b glycerol-3-p--- carbohydrate metabolic process /// glycerol-3-phosphate catalytic activity /// glycerol-3-phosphate dehydrogenase cytoplasm /// glycerol-3-phosphate metabolic process /// potassium ion transport /// metabolic (NAD+) activity /// binding /// cation transmembrane dehydrogenase complex process /// glycerol-3-phosphate catabolic process /// transporter activity /// oxidoreductase activity /// oxidation reduction oxidoreductase activity, acting on CH-OH group of donors /// oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor /// coenzyme binding /// NAD binding Dr.3305.1.S1_at 1.686949 2.271034 2.254819 1.82494 1 0.3905 0.604547 1 0.3905 ube2g1 ubiquitin-co--- post-translational protein modification /// regulation of ligase activity /// small conjugating protein ligase activity --- protein metabolic process Dr.3315.1.A1 at 1.375879 2.184275 2.091851 2.161524 1 0.967715 0.995 0.95759 0.9576 LOC100149027 similar to G------Dr.3333.1.A1 at -1.46164 -1.2661 -1.28216 -2.14035 1 1 1 0.911679 0.9117 LOC565291 similar to p------Dr.3335.1.A1_at 1.616738 2.26856 2.146606 1.763592 1 0.815942 0.855576 1 0.8159 metap1 methionyl a --- proteolysis /// cobalt ion transport aminopeptidase activity /// endopeptidase inhibitor activity /// --- peptidase activity /// metalloexopeptidase activity /// cobalt ion transmembrane transporter activity /// hydrolase activity /// metal ion binding /// cobalt ion binding

Dr.3337.1.S1_at -1.31035 -1.16815 -1.08145 2.038982 1 1 1 0.998 0.998 esco2 establishm--- DNA repair /// zinc ion transport /// cell cycle zinc ion binding /// acyltransferase activity /// transferase nucleus activity /// metal ion binding Dr.3341.1.A1 at 1.010967 1.078451 1.322075 2.054794 1 1 1 0.995 0.995 zgc:103767 zgc:103767------Dr.3347.1.S1 at 3.696005 6.042853 5.720147 5.293602 0.0897 0.036356 0.029734 0.080845 0.0297 fbl fibrillarin --- rRNA processing RNA binding nucleus Dr.3368.1.S1_at 1.577851 2.583011 2.749682 1.968625 1 0.393345 0.307719 1 0.3077 riok1 RIO kinase --- protein amino acid phosphorylation protein serine/threonine kinase activity /// protein tyrosine --- kinase activity /// ATP binding /// kinase activity

Dr.337.1.A1 at 1.394217 1.916549 1.863741 2.276462 1 1 1 0.934813 0.9348 ------Dr.3374.2.S1_at 1.132509 2.632005 2.277338 2.784056 1 0.624358 0.995 0.77 0.6244 ctsba cathepsin B--- proteolysis /// regulation of catalytic activity cysteine-type endopeptidase activity /// endopeptidase --- inhibitor activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity Dr.3389.1.A1 at 1.556035 2.07798 1.606111 1.436295 1 0.939 1 1 0.939 wu:fd13b08 wu:fd13b08------Dr.3402.1.A1 at 1.408693 2.517645 3.174649 2.64103 1 0.372641 0.676295 0.257654 0.2577 DKEY-24K20.1 novel prote------membrane /// integral to membrane Dr.3407.1.A1 at -1.25552 -2.16681 -2.63276 -2.07792 1 0.960456 0.691684 0.989 0.6917 sb:cb367 sb:cb367 ------extracellular matrix structural constituent proteinaceous extracellular matrix Dr.3417.1.S1_at 1.502153 1.937392 1.94272 2.744418 1 1 1 0.429762 0.4298 atp5h ATP syntha--- ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational proton-transporting two-sector ATPase mechanism /// hydrogen ion transporting ATPase activity, complex rotational mechanism Dr.3418.1.A1_at -1.14043 1.832714 4.41731 5.113785 1 1 0.494294 0.396821 0.3968 atp2b1a ATPase, C--- transport /// ion transport /// cation transport /// calcium ion nucleotide binding /// catalytic activity /// calcium-transporting membrane /// integral to membrane transport /// metabolic process ATPase activity /// calcium ion binding /// ATP binding /// calcium ion transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Dr.3421.1.A1_at -2.68111 -2.39057 -2.52243 -1.55616 0.486 0.901 0.545148 1 0.486 rrbp1 ribosome b--- protein transport --- integral to endoplasmic reticulum membrane

Dr.3447.1.S1_at 1.488006 2.537669 3.197569 4.47584 1 0.907 0.363453 0.131693 0.1317 rps21 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.3459.1.S1 at 2.596894 4.131267 3.660118 3.617831 0.340235 0.102509 0.177 0.087952 0.088 cd63 Cd63 antig ------membrane /// integral to membrane Dr.3463.1.S1_at 2.26283 4.07417 4.607394 3.410728 0.822 0.058644 0.037347 0.111263 0.0373 ssb Sjogren syn--- RNA processing nucleotide binding /// nucleic acid binding /// RNA binding nucleus /// ribonucleoprotein complex

Dr.347.1.A1 at 3.634624 4.597284 4.072464 2.877384 0.020401 0.008208 0.028278 0.14632 0.0082 ------Dr.3472.1.A1 at -2.15017 -1.81059 -1.89896 -2.33513 0.999955 1 1 0.98838 0.9884 LOC553451 hypothetica------Dr.3478.1.A1_at -1.95894 -2.19666 -2.72395 -1.93379 0.999955 0.66376 0.087119 0.9997 0.0871 mycl1b v-myc mye --- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// transcription nucleus transcription regulator activity Dr.3479.1.A1 at 1.666101 1.404656 1.184021 2.466525 1 1 1 0.3514 0.3514 wu:fb37e01 wu:fb37e01------Dr.348.1.S1_at -1.76507 -1.58259 -1.76338 -2.46362 1 1 1 0.597428 0.5974 rxrga retinoid x re--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// transcription nucleus /// nucleus transcription, DNA-dependent /// zinc ion transport /// factor activity /// steroid hormone receptor activity /// receptor transcription antitermination /// positive regulation of activity /// ligand-dependent nuclear receptor activity /// transcription from RNA polymerase II promoter retinoid-X receptor activity /// steroid binding /// zinc ion binding /// transcription activator activity /// sequence- specific DNA binding /// metal ion binding

Dr.3481.1.A1 at -1.37711 -1.4562 1.05625 2.081237 1 1 1 0.976817 0.9768 wu:fb37g07 wu:fb37g07------Dr.3492.1.A1 at 1.002283 1.361809 1.295552 2.102941 1 1 1 0.968307 0.9683 im:7161247 /// LOC55345 im:7161247------Dr.3494.1.A1_at 1.241397 1.905104 2.002008 2.061915 1 1 1 0.99934 0.9993 glrx3 glutaredoxi--- cell redox homeostasis electron carrier activity /// protein disulfide oxidoreductase --- activity Dr.3504.1.A1_at 1.514828 2.75145 2.588846 2.283975 1 0.267493 0.426581 0.773 0.2675 taz tafazzin --- heart looping /// heart development /// metabolic process /// acyltransferase activity integral to mitochondrial outer membrane positive regulation of heart contraction Dr.3510.1.A1 at 1.854014 2.658062 2.637201 2.723476 1 0.501366 0.511882 0.452 0.452 psmd11a proteasome ------Dr.3514.1.S1 at 1.625043 2.616102 2.300696 1.858758 1 0.193518 0.694599 1 0.1935 cox4nb cox4 neigh ------Dr.3518.1.A1 at 1.388092 1.648218 2.024116 2.580386 1 1 0.9997 0.185442 0.1854 LOC100149421 /// zgc:77 hypothetica------Dr.3519.1.A1 at 2.851217 3.366318 2.835481 2.73931 0.56765 0.293 0.346238 0.601275 0.293 wu:fb51a10 wu:fb51a10------Dr.3521.1.A1 at 1.228958 1.977014 1.907366 2.951678 1 0.999955 1 0.41878 0.4188 wu:fb51e06 wu:fb51e06------Dr.3522.1.S1_at -1.25016 -1.14434 1.113129 2.535079 1 1 1 0.823377 0.8234 chaf1b chromatin a--- mitotic cell cycle /// embryonic organ development /// retina ------development in camera-type eye Dr.3536.1.A1_at -1.66454 -1.48386 -2.9231 -2.3329 1 1 0.289773 0.87774 0.2898 zgc:158335 zgc:158335--- phosphate transport /// cell adhesion /// collagen catabolic structural molecule activity /// extracellular matrix structural collagen /// cytoplasm process constituent Dr.354.1.S1_at 1.47306 -1.56084 -2.0784 -2.00638 1 1 1 0.996511 0.9965 rho rhodopsin --- signal transduction /// G-protein coupled receptor protein rhodopsin-like receptor activity /// signal transducer activity membrane /// integral to membrane /// integral signaling pathway /// visual perception /// phototransduction /// receptor activity /// G-protein coupled receptor activity /// to membrane /// rhodopsin mediated phototransduction /// protein- photoreceptor activity /// photoreceptor activity /// retinal chromophore linkage /// response to stimulus binding

Dr.3545.1.A1 at -1.50193 -1.29016 1.160143 3.342081 1 1 1 0.089685 0.0897 zgc:92664 zgc:92664 ------Dr.3546.1.S1 at -2.53512 -3.49027 -1.63721 -2.4794 0.956 0.544 1 0.90947 0.544 gpr177 G protein-c------Dr.3557.1.S1 at 1.644059 1.933193 2.329617 1.546889 1 1 0.521639 1 0.5216 LOC572735 /// wdr75 similar to C ------nucleus Dr.3576.1.A1_at -1.57564 -2.11324 -2.98822 -2.22987 1 0.996244 0.188742 0.897347 0.1887 acox1 acyl-Coenz--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// acyl-CoA dehydrogenase activity /// cytoplasm /// peroxisome fatty acid metabolic process /// fatty acid beta-oxidation /// acyl-CoA oxidase activity /// aminoacyl-tRNA ligase activity metabolic process /// ATP binding /// electron carrier activity /// oxidoreductase activity /// oxidoreductase activity, acting on the CH-CH group of donors /// FAD binding Dr.3589.1.A1 at 2.036889 1.954583 1.123693 1.059531 0.989 1 1 1 0.989 wu:fb98e08 wu:fb98e08------Dr.359.1.A1 at 4.045194 6.968919 5.994204 4.335685 0.216619 0.009502 0.019536 0.022635 0.0095 zgc:153477 zgc:153477------Dr.3590.1.S1 at 3.070737 5.962441 6.769717 5.062444 0.268354 0.028664 0.021552 0.043975 0.0216 pwp2h PWP2 peri--- superoxide metabolic process metal ion binding --- Dr.3596.1.A1 at -1.52753 -1.71137 -2.21936 -1.77381 1 1 0.839 1 0.839 wu:fb72d11 wu:fb72d11------Dr.3598.1.S1 at 1.888167 2.925838 2.968061 3.079099 1 0.141674 0.14066 0.104381 0.1044 fam136a family with ------mitochondrion Dr.3606.1.A1 at 1.998209 2.723095 2.346807 2.321461 0.999955 0.807058 0.964549 0.933 0.8071 zgc:152873 zgc:152873------binding --- Dr.361.1.S1_at -1.00953 1.401944 1.919769 6.840342 1 1 1 0.023545 0.0235 seph selenoprote--- nucleosome assembly /// cell redox homeostasis DNA binding /// selenium binding chromosome, centromeric region /// condensed chromosome kinetochore /// nucleosome /// nucleus /// chromosome Dr.3611.2.S1 at -2.05139 -2.00747 -2.40457 -2.13035 1 1 0.823323 0.998 0.8233 zgc:86714 zgc:86714 ------Dr.3629.1.A1_at 3.612527 5.418606 4.534468 3.703929 0.246762 0.061084 0.073589 0.115884 0.0611 atp2a2b ATPase, C--- transport /// cation transport /// calcium ion transport /// nucleotide binding /// catalytic activity /// calcium-transporting membrane /// integral to membrane metabolic process /// proton transport ATPase activity /// ATP binding /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Dr.363.1.A1 at 1.515736 1.760027 1.759354 2.852501 1 1 1 0.13512 0.1351 fam76b family with ------Dr.3648.1.S1 at 1.305111 2.809072 1.707347 1.648847 1 0.455172 1 1 0.4552 tram1 translocatin------membrane /// integral to membrane Dr.3648.1.S2 at 2.486959 5.443731 3.175865 2.537864 0.134621 0.007999 0.12594 0.280314 0.008 tram1 translocatin------membrane /// integral to membrane Dr.365.1.A1 at 1.295618 1.435879 1.264641 2.386343 1 1 1 0.576801 0.5768 si:ch211-152c12.2 Si:ch211-1 ------kinase activity --- Dr.3651.1.A1 at -1.44158 -1.88038 -1.21276 -2.19582 1 1 1 0.985663 0.9857 LOC564346 similar to N------Dr.3652.1.A1 at -1.05966 -2.02457 -2.89419 -3.00425 1 1 0.551792 0.478 0.478 wu:fb78e09 wu:fb78e09------Dr.3676.1.A1 at 4.524261 6.178349 4.881327 3.903401 0.052929 0.034461 0.060906 0.073739 0.0345 wu:fb94b05 wu:fb94b05------Dr.3681.1.S1 at -1.0274 -4.44959 -5.50922 -4.21597 1 0.070414 0.072878 0.632211 0.0704 zgc:110380 zgc:110380--- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.3707.1.A1_at 1.965671 2.832915 2.236955 1.577091 1 0.661306 0.992731 1 0.6613 zgc:76988 zgc:76988 --- transport /// protein transport /// nuclear export nucleotide binding /// GTP binding /// GTP binding /// intracellular /// nucleus /// cytoplasm /// hydrolase activity endoplasmic reticulum /// Cajal body Dr.3713.1.A1 at 2.018057 2.188443 1.976709 1.488946 0.996244 0.972915 1 1 0.9729 flncb filamin C, g------Dr.3715.1.A1 at 1.78266 2.292931 1.953585 2.021789 1 0.824344 1 0.999955 0.8243 zgc:86838 zgc:86838 ------Dr.3731.1.A1 at 1.548626 2.257039 2.209874 2.121399 1 0.982331 0.987421 0.998 0.9823 cpsf3 cleavage an------hydrolase activity --- Dr.3736.1.A1 at 1.974583 2.318692 2.116634 1.618766 0.999955 0.912807 0.895466 1 0.8955 wu:fc04a02 wu:fc04a02------Dr.3740.1.A1 at -1.42631 -1.7554 -2.5533 -2.29954 1 1 0.265813 0.8496 0.2658 slc7a3 solute carri--- transport /// amino acid transport amino acid transmembrane transporter activity membrane /// integral to membrane Dr.3743.1.S1 at 3.18173 3.907644 3.64614 3.625055 0.025597 0.00994 0.010835 0.032654 0.0099 wdr43l WD repeat ------Dr.3746.1.A1 a at 2.646079 4.462115 3.556688 2.377369 0.213 0.01324 0.02717 0.42517 0.0132 zgc:110840 zgc:110840--- sequestering of lipid ------Dr.3746.1.A1 x at 2.378618 3.979584 2.715966 2.009658 0.498389 0.012968 0.139756 1 0.013 zgc:110840 zgc:110840--- sequestering of lipid ------Dr.3747.1.S1 at 1.538962 2.055034 2.120937 1.536706 1 0.998 0.997322 1 0.9973 zgc:64137 zgc:64137 --- negative regulation of translational initiation eukaryotic initiation factor 4E binding --- Dr.3758.1.A1 at 1.746782 2.15248 2.136818 1.813525 1 0.996882 0.987303 1 0.9873 aatf apoptosis a------nucleus Dr.3760.1.A1 at 1.521735 2.270609 2.080474 1.50097 1 0.990731 0.999955 1 0.9907 pdss1 prenyl (dec--- isoprenoid biosynthetic process transferase activity --- Dr.3762.1.S1 at 1.715662 2.021454 1.745027 1.294165 1 0.9997 1 1 0.9997 slc35e1 solute carri------membrane /// integral to membrane Dr.3763.1.S1 at 1.765605 3.716244 2.527292 1.634844 1 0.160903 0.397979 1 0.1609 lima1 LIM domain --- zinc ion transport zinc ion binding /// metal ion binding --- Dr.377.1.S1_at -1.1162 1.014652 1.379678 3.588483 1 1 1 0.074503 0.0745 prim1 primase po--- DNA replication /// DNA replication, synthesis of RNA DNA primase activity /// DNA-directed RNA polymerase alpha DNA polymerase:primase complex primer activity /// transferase activity Dr.3773.1.S1 at 3.037183 4.566584 2.991851 1.83726 0.303317 0.111593 0.349743 1 0.1116 uap1 UDP-N-act --- metabolic process nucleotidyltransferase activity --- Dr.3785.1.S1 at 1.082196 1.98834 2.03448 2.724203 1 1 0.999955 0.300906 0.3009 ------Dr.3788.1.A1 at 1.669036 1.83938 2.131527 3.708605 1 1 0.9997 0.27143 0.2714 ezh2 enhancer o------DNA binding nucleus Dr.38.1.A1 at 2.220301 1.048441 1.936022 -1.00151 0.966 1 1 1 0.966 sb:cb307 sb:cb307 ------Dr.3806.1.S1_at -1.6252 -1.47035 -2.96103 -3.35385 1 1 0.188222 0.551384 0.1882 zgc:55888 zgc:55888 --- proteolysis catalytic activity /// serine-type endopeptidase activity /// --- endopeptidase inhibitor activity /// peptidase activity /// hydrolase activity Dr.3813.1.A1 at 1.00695 1.695304 2.446029 2.200544 1 1 0.692157 0.986747 0.6922 flna filamin A, a ------Dr.3817.1.S1 at 3.040516 4.861821 3.537707 3.331391 0.219 0.036021 0.085785 0.179576 0.036 pdia4 protein disu--- cell redox homeostasis calcium ion binding /// isomerase activity endoplasmic reticulum Dr.3818.2.A1_at -1.17936 1.684883 1.634406 2.649221 1 1 1 0.125441 0.1254 slc39a7 solute carri--- transport /// ion transport /// zinc ion transport /// zinc ion zinc ion transmembrane transporter activity /// zinc ion membrane /// integral to membrane transport /// metal ion transport binding /// metal ion transmembrane transporter activity

Dr.382.1.S1 at 2.226498 3.644356 3.690478 3.569901 0.857 0.094866 0.079569 0.074886 0.0749 ncl /// zgc:152810 nucleolin /// ------nucleotide binding /// nucleic acid binding --- Dr.382.2.S1_at -1.16659 -3.44996 -4.66918 -3.49124 1 0.429843 0.077 0.236688 0.077 LOC798430 beta thymo--- cytoskeleton organization and biogenesis /// actin actin binding cytoplasm cytoskeleton organization and biogenesis /// sequestering of actin monomers Dr.3824.1.S1_at -1.63433 -1.13985 1.628194 2.757324 1 1 1 0.657155 0.6572 her9 hairy-relate--- transcription /// transcription termination /// regulation of DNA binding /// transcription regulator activity nucleus transcription, DNA-dependent /// transcription antitermination /// regulation of transcription /// negative regulation of neurogenesis Dr.3828.1.A1 at 1.129991 2.369537 2.317863 2.919544 1 0.885807 0.852 0.431 0.431 zgc:171310 zgc:171310------nucleotide binding /// nucleic acid binding --- Dr.3838.1.A1_at 2.707405 3.267298 2.728343 1.840988 0.537 0.305907 0.694936 1 0.3059 polr1c polymerase --- transcription DNA binding /// DNA-directed RNA polymerase activity /// nucleus protein dimerization activity Dr.3854.1.S1_at 3.000422 3.861235 2.689986 2.375839 0.149376 0.052057 0.434956 0.778 0.0521 sec23b Sec23 hom--- transport /// intracellular protein transport /// ER to Golgi protein binding /// zinc ion binding Golgi apparatus /// COPII vesicle coat vesicle-mediated transport /// protein transport /// vesicle- mediated transport /// embryonic neurocranium morphogenesis /// cartilage development Dr.3855.1.S1_at 2.77905 3.396594 3.397727 2.327087 0.030581 0.089514 0.027477 0.206247 0.0275 prmt7 protein argi------methyltransferase activity /// S-adenosylmethionine- --- dependent methyltransferase activity /// transferase activity

Dr.3862.1.A1 at 12.31962 48.69683 58.40833 47.17665 0.047398 0.006236 0.004443 0.005484 0.0044 ------Dr.3862.2.S1 at 2.559589 10.291 10.83626 9.584 0.645483 0.013275 0.011682 0.007658 0.0077 ------Dr.3864.1.A1 at 2.816507 3.670141 3.035716 2.520146 0.194103 0.035846 0.114288 0.509346 0.0358 wu:fc35d05 wu:fc35d05------Dr.3865.1.A1 at -1.42777 -1.65277 -2.43167 -1.79939 1 1 0.95265 1 0.9527 wu:fc35e02 wu:fc35e02------Dr.3866.1.A1 at 1.514756 2.004436 1.600492 1.879777 1 0.99934 1 1 0.9993 zgc:92043 zgc:92043 ------Dr.3875.1.A1 at 1.720859 2.023149 2.004821 1.599538 1 0.9997 1 1 0.9997 id:ibd1017 id:ibd1017 ------Dr.3880.1.S2_at 1.410981 2.383513 1.968337 2.592176 1 0.81268 1 0.636293 0.6363 bax bcl2-assoc--- apoptosis /// regulation of apoptosis /// positive regulation of ------apoptosis /// positive regulation of caspase activity /// positive regulation of caspase activity /// response to cadmium ion /// response to methylmercury

Dr.3891.1.A1 at -1.00646 1.050018 1.517971 2.269267 1 1 1 0.838374 0.8384 6-Sep septin 6 --- cell cycle nucleotide binding /// protein binding /// GTP binding septin complex Dr.39.1.S1_at 1.422197 2.230922 2.412082 2.316567 1 0.451563 0.56132 0.305215 0.3052 vdac2 voltage-dep--- transport /// anion transport voltage-gated anion channel activity mitochondrial outer membrane /// membrane /// integral to membrane Dr.390.1.S1 at 2.780904 3.486498 3.842209 3.288218 0.357483 0.147901 0.091888 0.16 0.0919 cdv3 carnitine de------cytoplasm Dr.3905.1.S1 at 1.526894 2.167367 2.047669 1.487202 1 0.999917 0.999955 1 0.9999 wdsof1 WD repeat--- rRNA processing /// ribosome biogenesis --- nucleus /// ribonucleoprotein complex Dr.3918.1.A1 at 1.783828 2.981624 2.552696 2.350437 1 0.437335 0.506779 0.939 0.4373 lonp1 lon peptida------Dr.3932.1.S1_at -3.663 -1.78706 -1.97818 1.117867 0.020965 1 0.999955 1 0.021 p4ha1 procollagen--- protein metabolic process /// collagen catabolic process binding /// iron ion binding /// oxidoreductase activity /// --- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Dr.3936.1.A1 at 2.098949 1.373259 1.143868 1.339948 0.981 1 1 1 0.981 zgc:162730 zgc:162730------nucleic acid binding /// zinc ion binding --- Dr.395.1.A1_at -1.66124 -2.33446 -3.05443 -2.50664 1 0.389 0.057915 0.212239 0.0579 st8sia6 ST8 alpha- --- protein amino acid glycosylation alpha-N-acetylneuraminate alpha-2,8-sialyltransferase Golgi apparatus /// membrane /// integral to activity /// alpha-N-acetylneuraminate alpha-2,8- membrane /// integral to Golgi membrane sialyltransferase activity /// sialyltransferase activity /// transferase activity /// transferase activity, transferring glycosyl groups Dr.3950.1.A1_at 1.638848 2.302987 2.90264 2.595568 1 0.852348 0.445 0.472281 0.445 zgc:113183 zgc:113183------nucleic acid binding /// DNA binding /// helicase activity /// --- ATP binding Dr.3953.1.S1 at 1.534948 2.615451 2.946693 3.270445 1 0.131233 0.076656 0.050826 0.0508 snrpd3l small nucle--- mRNA metabolic process nucleic acid binding ribonucleoprotein complex Dr.3957.1.S1_at 2.00032 2.337255 2.139999 1.143147 0.998961 0.916832 0.999917 1 0.9168 pop5 processing --- tRNA processing /// RNA metabolic process ribonuclease P activity /// ribonuclease activity /// hydrolase nucleus activity Dr.3958.1.A1 at -1.05391 -1.06846 1.071296 2.960262 1 1 1 0.212377 0.2124 zgc:158618 zgc:158618--- mitotic cell cycle /// mitosis --- nucleus Dr.3961.1.A1 at 1.726471 2.165089 2.261245 2.39464 1 0.902772 0.756 0.552 0.552 DKEY-245P14.6 similar to P ------Dr.3966.1.A1 at 1.11888 1.493999 3.988901 4.739646 1 1 0.231825 0.119069 0.1191 zgc:66052 zgc:66052 --- muscle development ------Dr.3986.1.S1_at -1.13341 -2.14519 -2.07698 -2.90541 1 0.9997 0.994582 0.514978 0.515 nr2f2 nuclear rec--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.3991.1.A1 at 4.038583 2.249106 1.407449 1.021916 0.082927 0.939 1 1 0.0829 wu:fd02h10 wu:fd02h10------Dr.3996.1.A1 at 2.021501 2.368849 2.54144 2.210986 0.995 0.606 0.353545 0.851586 0.3535 zgc:101724 zgc:101724--- dephosphorylation phosphatase activity --- Dr.4001.1.S1 at 1.146504 2.737605 3.439976 2.113111 1 0.414851 0.199979 1 0.2 wu:fa99f12 wu:fa99f12 ------Dr.4011.1.S1 at -1.39889 -1.6637 -1.42211 -2.06063 1 1 1 0.974275 0.9743 sb:cb11 sb:cb11 ------Dr.4017.1.S1_at 3.52832 4.465834 3.802394 3.094968 0.315346 0.212853 0.249899 0.457 0.2129 ddx49 DEAD (Asp------nucleotide binding /// nucleic acid binding /// helicase activity --- /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.4032.1.A1 at -1.43537 -2.26524 -2.27622 -2.21559 1 0.83 0.833 0.882946 0.83 wu:fa11h07 wu:fa11h07------Dr.4037.1.A1 at 3.052908 3.852078 4.05691 2.985125 0.310938 0.176777 0.089879 0.276869 0.0899 zgc:77488 zgc:77488 ------Dr.4039.3.S1 at -1.86908 -2.4023 -1.98252 -2.50363 1 0.957754 1 0.904 0.904 si:ch211-125e6.12 si:ch211-12------binding /// sugar binding --- Dr.4042.1.A1 at -1.06628 -2.18374 -1.72475 1.592378 1 0.970026 1 1 0.97 zgc:158367 zgc:158367------zinc ion binding intracellular Dr.4047.1.S1 at 2.953137 6.351195 7.022429 5.225003 0.665 0.033363 0.03138 0.049426 0.0314 scyba small induc--- immune response cytokine activity /// chemokine activity extracellular region Dr.4049.1.S1 at 1.997088 6.783225 9.647658 14.35469 0.99994 0.009223 0.007728 0.007822 0.0077 nutf2 nuclear tran--- transport --- intracellular Dr.4050.1.A1 at 1.988771 2.997333 2.656717 2.797725 1 0.094047 0.10887 0.067173 0.0672 LOC562285 similar to ri------Dr.4057.1.S1_at 1.142459 2.065845 1.912095 1.720138 1 0.995911 1 1 0.9959 zgc:101045 zgc:101045------endoplasmic reticulum /// endoplasmic reticulum membrane /// membrane /// integral to membrane Dr.4060.1.S1_at 2.322866 1.666712 1.340555 1.39746 0.999 1 1 1 0.999 hadhb hydroxyacy --- metabolic process catalytic activity /// acyltransferase activity /// transferase --- activity Dr.4078.1.A1 at 3.288264 3.49637 2.645352 2.359063 0.145142 0.174406 0.389647 0.873 0.1451 wu:fb06h03 wu:fb06h03------Dr.4087.1.A1_at 2.326559 2.630772 2.7604 1.670959 0.706337 0.471372 0.487371 1 0.4714 ncl1 nicalin --- multicellular organismal development /// regulation of signal --- signal recognition particle, endoplasmic transduction /// regulation of signal transduction /// negative reticulum targeting /// plasma membrane /// regulation of signal transduction membrane /// integral to membrane Dr.4091.1.S1_at 1.843483 3.258473 4.010523 5.61871 1 0.52654 0.093837 0.0298 0.0298 rpl8 ribosomal p--- translation RNA binding /// structural constituent of ribosome /// rRNA intracellular /// cytoplasm /// ribosome /// binding ribonucleoprotein complex Dr.4096.1.S1 at 1.019888 -2.61981 -3.22388 -2.72866 1 0.11492 0.042256 0.392327 0.0423 zgc:65861 zgc:65861 --- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.4108.1.S1_at -1.18579 1.280209 1.9552 3.286657 1 1 1 0.270569 0.2706 msh6 mutS homo--- mismatch repair DNA binding /// double-stranded DNA binding /// ATP --- binding /// mismatched DNA binding /// mismatched DNA binding /// guanine/thymine mispair binding Dr.4113.1.S1 at 3.005458 4.133896 4.382773 4.197949 0.220095 0.109801 0.080524 0.075424 0.0754 etf1 eukaryotic t--- translational termination translation release factor activity, codon specific cytoplasm Dr.4113.1.S2 at 2.95188 3.679239 3.412896 2.935829 0.341646 0.158826 0.195758 0.346895 0.1588 etf1 eukaryotic t--- translational termination translation release factor activity, codon specific cytoplasm Dr.4119.1.S1_at 1.655454 -1.60764 -2.03754 -2.18724 1 1 0.999955 0.996 0.996 guca1b guanylate c--- calcium ion transport calcium channel activity /// calcium ion binding /// calcium --- ion binding /// calcium channel inhibitor activity /// guanylate cyclase activator activity Dr.4121.1.A1 at 1.453996 2.088747 2.11875 2.257995 1 0.999955 0.999955 0.957423 0.9574 nup88 nucleoporin ------membrane Dr.4123.1.S1_at 4.362176 5.302751 4.953829 3.251176 0.081535 0.024603 0.036656 0.086858 0.0246 mki67ip mki67 (FHA--- multicellular organismal development nucleotide binding /// nucleic acid binding /// RNA binding nucleus

Dr.4127.1.A1 a at -1.23731 -1.0455 1.158203 3.703029 1 1 1 0.098635 0.0986 dlgap5 discs, large --- cell-cell signaling ------Dr.4128.1.A1 at -2.58006 -2.32358 -2.55797 -3.66354 0.413275 0.746244 0.521302 0.179576 0.1796 ------Dr.413.2.A1 at 1.584105 -2.03482 -2.11054 -1.42017 1 0.999955 0.997143 1 0.9971 LOC792823 hypothetica------Dr.4140.1.S1_at 2.62328 3.441927 3.566157 3.46063 0.598 0.081511 0.062608 0.102192 0.0626 cox7a2l cytochrome ------cytochrome-c oxidase activity /// electron carrier activity mitochondrial respiratory chain

Dr.4147.1.S1_at -1.36391 -1.66733 -1.70985 -2.14294 1 1 1 0.878 0.878 glula glutamate-a--- glutamine biosynthetic process /// nitrogen compound catalytic activity /// glutamate-ammonia ligase activity /// --- metabolic process ligase activity Dr.4157.1.S1_at -1.26593 -1.49694 -2.18616 -1.62901 1 1 0.287668 1 0.2877 tpi1b triosephosp--- metabolic process catalytic activity /// triose-phosphate isomerase activity /// --- isomerase activity Dr.4161.1.A1_at 3.075085 4.670716 4.639596 4.214138 0.847536 0.234718 0.178946 0.218801 0.1789 zgc:92215 zgc:92215 --- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm histidyl-tRNA aminoacylation histidine-tRNA ligase activity /// ATP binding Dr.4169.1.A1 at 1.578332 2.640893 2.390775 2.172161 1 0.739 0.923812 0.99934 0.739 wu:fb57a10 wu:fb57a10------Dr.4179.1.S1_at 2.205445 1.879869 2.037044 2.065019 0.649 1 0.99934 0.98777 0.649 ptp4a1 protein tyro--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine/serine/threonine phosphatase activity /// --- phosphatase activity Dr.4190.1.A1 at 4.653679 4.246876 1.744815 1.728397 0.268745 0.272 1 1 0.2687 zgc:91794 zgc:91794 --- proteolysis carboxypeptidase activity /// zinc ion binding --- Dr.4190.2.S1 at 2.037926 2.321553 1.33284 1.15141 0.997322 0.562312 1 1 0.5623 zgc:91794 zgc:91794 --- proteolysis carboxypeptidase activity /// zinc ion binding --- Dr.4198.1.S1_at -7.65753 -9.15197 -9.59705 -8.81563 0.814 0.783682 0.763795 0.809488 0.7638 mhc1ufa major histo --- immune response /// antigen processing and presentation --- membrane /// integral to membrane /// MHC class I protein complex Dr.4206.1.A1_at 1.382918 1.788711 1.866763 2.682039 1 1 1 0.264158 0.2642 zgc:76977 zgc:76977 --- chromatin assembly or disassembly /// transcription /// --- nucleus transcription termination /// regulation of transcription, DNA- dependent /// chromatin modification /// transcription antitermination Dr.4217.1.S1_at -1.13665 2.036654 2.184435 2.013568 1 0.999917 0.929438 0.997562 0.9294 rpn2 ribophorin I --- protein amino acid N-linked glycosylation via asparagine dolichyl-diphosphooligosaccharide-protein glycotransferase endoplasmic reticulum membrane /// activity oligosaccharyl transferase complex Dr.4225.1.A1 at 1.789639 3.384085 3.758585 3.951532 1 0.102953 0.060906 0.057055 0.0571 npm3 nucleophos ------nucleic acid binding nucleus Dr.4248.1.A1 at -1.93027 -1.47506 -2.09217 -2.19362 1 1 0.999325 0.989 0.989 wu:fa98e08 wu:fa98e08------Dr.425.1.A1 at -1.16512 -1.12993 1.072111 2.247869 1 1 1 0.87 0.87 wdhd1 WD repeat ------Dr.4265.1.A1 at 1.921813 2.678553 3.149226 2.836487 1 0.74991 0.166088 0.303711 0.1661 LOC791874 hypothetica--- translation ------Dr.4266.1.A1 at 2.329091 1.455616 1.125438 -1.05246 0.462424 1 1 1 0.4624 ------Dr.4267.1.A1 at 2.177495 1.424837 1.220179 -1.43881 0.962505 1 1 1 0.9625 fdps farnesyl dip--- isoprenoid biosynthetic process transferase activity --- Dr.4272.1.S1_at 1.329524 1.983493 1.710344 2.56612 1 1 1 0.557822 0.5578 atp5d ATP syntha--- ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational proton-transporting two-sector ATPase mechanism /// hydrogen ion transporting ATPase activity, complex rotational mechanism Dr.4274.2.A1_at 3.777607 6.038525 6.218997 4.480784 0.197546 0.048336 0.06847 0.0897 0.0483 zgc:110388 zgc:110388--- ribosome biogenesis --- intracellular /// ribosome /// ribonucleoprotein complex Dr.4277.1.S1_at 2.007157 1.803927 1.444551 -1.04979 0.995911 1 1 1 0.9959 ankh ankylosis, p--- transport /// phosphate transport /// regulation of bone inorganic phosphate transmembrane transporter activity /// membrane /// integral to membrane /// integral mineralization phosphate transmembrane transporter activity to membrane /// outer membrane

Dr.428.1.S1 at -1.88279 -2.28121 -3.91163 -3.04709 1 0.916 0.111616 0.405548 0.1116 mid1ip1 MID1 intera--- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.4286.1.A1 at 2.795299 3.846792 3.521518 3.352365 0.120253 0.054153 0.050468 0.049807 0.0498 zgc:136473 zgc:136473--- protein folding unfolded protein binding prefoldin complex Dr.4288.1.S1_at 3.103836 4.511373 4.306564 4.593758 0.555 0.216306 0.232738 0.214934 0.2149 abcf1 ATP-bindin------nucleotide binding /// ATP binding /// ATPase activity /// --- nucleoside-triphosphatase activity Dr.4295.1.S1_at 1.154503 1.283387 1.944753 2.428251 1 1 1 0.866836 0.8668 rfc4 replication f--- DNA replication /// retina development in camera-type eye nucleotide binding /// DNA binding /// DNA clamp loader nucleus /// DNA replication factor C complex activity /// ATP binding /// nucleoside-triphosphatase activity

Dr.4299.1.S1 at -1.65076 -2.20647 -2.4308 -1.51368 1 0.845913 0.492227 1 0.4922 wu:fb83d05 wu:fb83d05------Dr.4300.1.A1 at -1.75829 -2.34452 -1.98609 -1.07022 1 0.825807 0.999955 1 0.8258 im:6907673 im:6907673------Dr.4305.1.A1 at 2.194688 2.829586 2.153304 2.322359 0.57 0.094665 0.829688 0.594927 0.0947 wsb1 SOCS box---- intracellular signaling cascade ------Dr.4309.1.A1 at -1.33843 -1.05415 1.000803 2.778004 1 1 1 0.206525 0.2065 LOC571625 similar to Im--- mitosis /// chromosome condensation binding nucleus Dr.4310.1.S1 at -1.83595 -2.15378 -1.6116 -3.02176 1 0.813474 1 0.069409 0.0694 ------Dr.4314.1.A1 a at -2.07088 -2.55684 -1.76689 -2.42585 1 0.46554 1 0.509294 0.4655 LOC100150560 similar to p ------Dr.4325.1.A1_at -1.92107 -2.41463 -2.70129 -2.24942 1 0.083777 0.033552 0.136081 0.0336 bcat2 branched c--- metabolic process /// branched chain family amino acid catalytic activity /// branched-chain-amino-acid transaminase --- metabolic process activity /// transaminase activity /// transferase activity

Dr.4330.1.A1 at 2.569375 3.519276 2.700682 1.696817 0.483874 0.297454 0.56388 1 0.2975 heatr3 HEAT repe--- proteolysis serine-type endopeptidase activity /// binding --- Dr.4336.1.A1 at 2.134092 2.661401 2.695207 1.647652 0.983791 0.50427 0.59187 1 0.5043 wu:fb98d04 wu:fb98d04------Dr.4343.1.S1 at 1.609025 2.274807 1.990574 1.772105 1 0.876 1 1 0.876 fam3c family with ------Dr.4357.1.A1 at 1.124988 1.037395 1.62793 2.863155 1 1 1 0.854 0.854 wu:fi84d07 wu:fi84d07 ------Dr.4358.1.A1 at 1.419786 2.575662 2.076103 2.37324 1 0.585 0.999955 0.757581 0.585 LOC560112 similar to te------Dr.4368.1.A1_a_at 3.067516 2.976269 2.834878 2.469983 0.613609 0.479177 0.269588 0.628 0.2696 ddx51 DEAD (Asp--- rRNA processing /// ribosome biogenesis nucleotide binding /// nucleic acid binding /// RNA binding /// nucleus helicase activity /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.4369.1.A1 at -1.13997 -2.0592 -1.99371 -2.02837 1 0.99934 1 1 0.9993 wu:fc06d01 wu:fc06d01------Dr.4370.1.A1_at 1.810093 2.179601 1.848949 2.20346 1 0.994186 1 0.973183 0.9732 dnm1l 1------nucleotide binding /// GTPase activity /// GTP binding /// cytoplasm /// membrane hydrolase activity Dr.4385.1.A1 at 1.837495 2.318171 1.919195 2.226261 1 0.71826 1 0.717 0.717 zgc:91836 zgc:91836 --- pseudouridine synthesis RNA binding /// pseudouridine synthase activity --- Dr.4387.2.S1 at 1.630474 2.696262 3.335072 4.159865 1 0.628 0.162434 0.071744 0.0717 LOC100147859 similar to T------Dr.4407.1.A1 at 1.11179 1.242763 1.219987 2.081359 1 1 1 0.939 0.939 smc1a structural m--- chromosome organization and biogenesis protein binding /// ATP binding /// ATPase activity chromosome Dr.4409.1.S1 at -3.92055 -2.84505 -2.71565 -3.89851 0.205922 0.493775 0.601134 0.156123 0.1561 cd9l CD9 antige------membrane /// integral to membrane Dr.441.1.S1 at -4.05078 -9.47919 -11.0721 -10.0482 0.193646 0.041735 0.034461 0.043867 0.0345 col9a2 procollagen--- phosphate transport /// collagen catabolic process --- cytoplasm Dr.4411.1.A1 at -1.59524 -3.22926 -4.77522 -4.31842 1 0.642826 0.111 0.025845 0.0258 ------Dr.4412.1.S1 at 1.610013 2.632213 3.002574 3.542791 1 0.3181 0.061586 0.067249 0.0616 LOC100149126 /// naca hypothetica--- transport /// protein transport ------Dr.4412.10.S1 at 1.675668 2.109552 2.120702 2.131199 1 0.784477 0.992263 0.707749 0.7077 eif4g2a eukaryotic t--- mesoderm development /// RNA metabolic process binding /// protein binding --- Dr.4412.14.A1 at 1.264465 -1.27498 -1.60978 2.467654 1 1 1 0.515 0.515 zgc:110159 zgc:110159--- intracellular signaling cascade ------Dr.4412.16.A1 at 1.501098 -1.12854 -1.49152 2.3172 1 1 1 0.931245 0.9312 zgc:110159 Zgc:11015 --- intracellular signaling cascade ------Dr.4412.17.A1 at 2.224613 1.170402 -1.09111 1.255142 0.961855 1 1 1 0.9619 f11r F11 recept ------receptor activity --- Dr.4412.18.A1 at 1.903317 2.749181 2.428388 2.179212 1 0.457544 0.915173 0.992263 0.4575 hnrnpu Heterogene------nucleic acid binding ribonucleoprotein complex Dr.4412.19.S1_s_at -1.88277 -1.40218 -1.20067 3.689941 1 1 1 0.040991 0.041 top2a topoisomer--- DNA metabolic process /// DNA topological change nucleotide binding /// DNA binding /// DNA topoisomerase chromosome activity /// DNA topoisomerase (ATP-hydrolyzing) activity /// ATP binding /// isomerase activity

Dr.4412.4.S1_at 1.326374 2.338771 2.687464 3.576304 1 0.171587 0.104 0.009259 0.0093 rps4x ribosomal p--- translation RNA binding /// structural constituent of ribosome /// rRNA intracellular /// ribosome /// ribonucleoprotein binding complex Dr.4412.6.S1 at 1.615016 2.822878 3.634389 4.935154 1 0.714976 0.201 0.06079 0.0608 zgc:92371 zgc:92371 --- translation structural constituent of ribosome intracellular /// ribosome Dr.4412.8.S1 a at -2.09588 -2.10982 -1.54428 -2.50267 0.997322 0.941698 1 0.663 0.663 LOC793100 /// si:dkey-46similar to A ------endopeptidase inhibitor activity /// protein binding extracellular region Dr.4416.1.A1_at 1.055602 1.970994 5.6292 13.19082 1 0.99934 0.018175 0.013248 0.0132 tubb5 tubulin, bet--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// cytoskeleton /// microtubule /// /// protein polymerization activity /// structural molecule activity /// GTP binding protein complex

Dr.4416.3.A1_at 1.396079 2.879644 8.037163 18.68132 1 0.268874 0.00796 0.009699 0.008 tubb5 Tubulin, be--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// cytoskeleton /// microtubule /// /// protein polymerization activity /// structural molecule activity /// GTP binding protein complex

Dr.4422.1.A1 at -1.09921 -2.02297 -1.92079 -1.517 1 0.984 1 1 0.984 tsc1b tuberous sc------Dr.4423.1.S1 at 2.80564 3.993055 3.182198 2.164612 0.291927 0.041676 0.072168 0.861 0.0417 hccs holocytochr------holocytochrome-c synthase activity mitochondrion Dr.4435.1.A1 at 1.728744 2.045862 2.011849 1.8578 1 0.99321 0.99934 1 0.9932 nupl1 nucleoporin ------membrane Dr.4444.1.S1 at 2.02686 1.25967 1.131393 1.141618 0.998 1 1 1 0.998 zgc:110069 zgc:110069------Dr.4446.1.A1 at -2.03073 -2.25299 -1.75329 -2.60672 1 0.973527 1 0.847 0.847 wu:fc41f02 wu:fc41f02 ------Dr.4451.1.S1 at -2.58758 -3.37044 -3.73108 -3.3703 0.918417 0.624128 0.507674 0.625 0.5077 zgc:55363 zgc:55363 ------calcium ion binding --- Dr.4457.1.S1 at 1.246076 2.07013 1.809555 1.488601 1 0.9997 1 1 0.9997 hnrpr heterogene------nucleic acid binding ribonucleoprotein complex Dr.4460.1.A1 at -1.14119 -1.0038 -1.03321 3.005454 1 1 1 0.164639 0.1646 wu:fc30c07 wu:fc30c07------Dr.4462.1.A1_at 2.638792 3.95946 4.085579 2.93381 0.57 0.126621 0.0493 0.3724 0.0493 LOC562037 hypothetica--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm prolyl-tRNA aminoacylation proline-tRNA ligase activity /// ATP binding Dr.4465.1.A1 at 1.372374 1.996147 1.831402 2.189297 1 1 1 0.982 0.982 hdac6 histone dea------zinc ion binding --- Dr.4467.1.S1 at 3.026797 1.279577 1.00041 -1.51935 0.73037 1 1 1 0.7304 wu:fc31g06 wu:fc31g06------Dr.4479.1.A1 at -1.06515 -1.01798 -1.08948 2.624209 1 1 1 0.775159 0.7752 si:ch211-244o22.2 si:ch211-24------Dr.4481.1.A1 at -2.18101 -2.15076 -2.67815 -1.65241 0.99161 0.991876 0.532992 1 0.533 zgc:77071 zgc:77071 --- oxidation reduction electron carrier activity /// oxidoreductase activity --- Dr.4485.1.S1 x at -1.37258 -1.65803 -1.32782 -2.18502 1 1 1 0.890984 0.891 ------Dr.4485.2.S1 at -1.48541 -1.61641 -1.41451 -2.12314 1 1 1 0.914768 0.9148 ------Dr.4485.3.A1 at -1.39416 -1.65294 -1.40744 -2.07686 1 1 1 0.990497 0.9905 ------Dr.4498.1.S1_at 1.429832 2.131049 2.311748 1.980914 1 0.943 0.778826 0.99994 0.7788 zgc:103509 zgc:103509--- rRNA processing DNA binding /// RNA binding exosome (RNase complex) /// nucleus /// cytoplasm Dr.45.1.A1 at 1.404615 2.280012 1.857528 1.953951 1 0.898232 1 1 0.8982 wu:fa01b10 wu:fa01b10------Dr.450.1.S1_at -1.53522 -1.95766 -2.52744 -2.79387 1 1 0.657529 0.4488 0.4488 cahz carbonic an--- one-carbon compound metabolic process /// zinc ion carbonate dehydratase activity /// zinc ion binding /// lyase --- transport /// hypotonic salinity response activity /// metal ion binding Dr.4500.1.A1 at 2.221549 2.267851 1.81077 1.634024 0.999 0.971 1 1 0.971 zgc:92866 zgc:92866 ------Dr.4503.1.S2_at 3.130776 4.382302 3.661154 2.971246 0.346736 0.158662 0.140082 0.311721 0.1401 hspa9 heat shock --- protein folding /// response to stress /// hemopoiesis nucleotide binding /// ATP binding /// ATP binding /// mitochondrial matrix ATPase activity /// unfolded protein binding Dr.4526.1.A1_at 2.706134 3.14404 2.731901 2.349519 0.611621 0.34353 0.5156 0.837 0.3435 lonp2 lon peptida--- proteolysis /// ATP-dependent proteolysis /// defense nucleotide binding /// ATP-dependent peptidase activity /// peroxisome response /// peroxisome organization and biogenesis serine-type endopeptidase activity /// endopeptidase inhibitor activity /// ATP binding /// peptidase activity /// hydrolase activity /// ATPase activity /// nucleoside-triphosphatase activity Dr.455.1.A1 at -1.02522 1.88724 1.67183 30.6165 1 1 1 0.033791 0.0338 ccnf cyclin F ------nucleus Dr.4551.2.A1 at -1.36048 -3.26855 -2.33532 -2.22272 1 0.345856 0.741151 0.911679 0.3459 wu:fb16h09 wu:fb16h09------Dr.4556.1.S1 at -1.76691 -1.12772 1.405808 3.063959 1 1 1 0.046061 0.0461 rpa2 replication ------nucleic acid binding --- Dr.4573.1.A1 at 2.381529 1.873129 1.212035 2.245599 0.99 1 1 0.992263 0.99 zgc:92326 zgc:92326 ------sugar binding --- Dr.4580.2.S1 at -1.61523 -1.93541 -1.32364 -2.38831 1 1 1 0.673293 0.6733 zgc:63734 Zgc:63734 ------Dr.4585.1.S1 at 1.047611 1.59362 1.947312 2.519187 1 1 1 0.211282 0.2113 pdcd5 programme------DNA binding --- Dr.4589.1.A1 at 1.340458 2.04053 1.675286 1.261288 1 0.996 1 1 0.996 wu:fc68e09 wu:fc68e09------Dr.4590.1.A1_at -1.83144 -2.41974 -2.71689 -2.57752 1 0.144679 0.017237 0.098174 0.0172 tob1a transducer --- dorsal/ventral pattern formation /// Wnt receptor signaling protein binding nucleus /// cytoplasm pathway /// BMP signaling pathway /// Wnt receptor signaling pathway through beta-catenin Dr.4594.1.S1 at -1.55252 -1.68506 -2.02187 -1.31815 1 1 0.99994 1 0.9999 nt5c2 5'-nucleotid------Dr.4597.1.S1 at 1.004668 1.059246 1.110971 4.775383 1 1 1 0.03559 0.0356 ------Dr.4603.1.A1 at 1.39996 -1.7456 -1.84845 -2.16291 1 1 1 0.929 0.929 wu:fc76h12 wu:fc76h12------Dr.4609.1.S1_at 1.456954 1.917016 1.994736 2.090558 1 1 0.999955 0.999 0.999 ywhaqa tyrosine 3-m------monooxygenase activity /// protein domain specific binding ---

Dr.461.1.A1 at 4.071996 5.767973 5.220584 2.38982 0.083134 0.036196 0.0446 0.850337 0.0362 wu:fb71g04 wu:fb71g04------Dr.4615.2.S1 at 1.408951 -1.35053 -2.07978 -1.80791 1 1 0.94268 1 0.9427 ------Dr.4624.1.A1 at -1.28463 -3.81601 -2.74211 -2.79077 1 0.383683 0.749745 0.689069 0.3837 wu:fc83a09 wu:fc83a09------Dr.4647.1.S1_at -2.62366 1.043279 1.066027 1.40102 0.795323 1 1 1 0.7953 zgc:56330 zgc:56330 --- regulation of translation /// negative regulation of translation protein binding /// eukaryotic initiation factor 4E binding --- /// negative regulation of translational initiation

Dr.4649.1.A1_a_at 1.197548 2.04035 -1.18901 -1.08864 1 0.999917 1 1 0.9999 phc2 polyhomeot--- zinc ion transport /// multicellular organismal development DNA binding /// zinc ion binding /// metal ion binding nucleus

Dr.4658.1.S1_at 1.074916 1.643464 2.068024 1.585453 1 1 0.999 1 0.999 wdr46 WD repeat --- translation /// tRNA aminoacylation for protein translation nucleotide binding /// aminoacyl-tRNA ligase activity /// ATP cytoplasm binding Dr.4660.1.S1 at 3.125678 5.700851 4.747499 5.342434 0.212894 0.052958 0.050789 0.035332 0.0353 slc16a8 solute carri--- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.4675.1.A1 at 1.526781 2.079699 2.086968 1.439774 1 0.994 0.999955 1 0.994 ------Dr.4682.1.A1 at 2.028174 2.845626 2.008508 1.29832 0.989 0.135712 1 1 0.1357 id:ibd1064 id:ibd1064 ------Dr.4685.1.S1 at 1.212446 1.791782 2.217479 2.430253 1 1 0.890541 0.73037 0.7304 zgc:92177 zgc:92177 ------Dr.4688.1.A1 at 2.271414 3.101972 2.76037 2.94489 0.543 0.091981 0.080113 0.067827 0.0678 im:7159098 im:7159098------Dr.4703.1.S1 at -1.9089 -1.775 -1.39836 2.885252 1 1 1 0.352516 0.3525 ------Dr.4703.1.S2_at -1.41667 -1.00192 1.009492 5.822623 1 1 1 0.018376 0.0184 zgc:112296 zgc:112296--- protein amino acid phosphorylation /// transmembrane ephrin receptor activity /// ATP binding membrane /// integral to membrane receptor protein tyrosine kinase signaling pathway Dr.4705.1.S1 at 1.383454 2.339817 2.602074 1.761721 1 0.598 0.564333 1 0.5643 nol10 nucleolar p------nucleus Dr.4713.1.S1_at -1.8237 -2.1109 -1.89972 -1.77456 1 0.954804 1 1 0.9548 stau2 staufen, RN--- transport /// germ cell development /// germ cell migration RNA binding /// double-stranded RNA binding intracellular /// microtubule

Dr.4718.1.S1 at 1.629815 1.901578 1.979171 2.032216 1 1 1 0.848594 0.8486 nup50 nucleoporin --- intracellular transport --- membrane Dr.4726.1.A1 at 1.529954 2.475694 2.425342 1.754553 1 0.093448 0.68225 1 0.0934 atpaf2 ATP syntha------Dr.4736.1.A1 at -1.30443 -1.62108 -1.24497 -2.07681 1 1 1 0.988927 0.9889 ------Dr.4738.1.A1 at 2.555731 2.446545 2.287919 2.030274 0.128736 0.163136 0.339451 0.99934 0.1287 wu:fb12g02 wu:fb12g02------Dr.4751.1.S1_x_at -1.85166 -1.7498 -2.11957 -2.13232 1 1 0.885228 0.993617 0.8852 aldh2a aldehyde d --- cellular aldehyde metabolic process /// metabolic process /// 3-chloroallyl aldehyde dehydrogenase activity /// --- oxidation reduction oxidoreductase activity Dr.4756.1.A1 at 1.24934 2.068396 1.966667 1.448504 1 0.9997 1 1 0.9997 wu:fb08f09 wu:fb08f09 ------Dr.4765.1.S1 at 1.999528 2.046098 1.87066 2.545118 0.998961 1 1 0.297782 0.2978 txndc9 thioredoxin ------Dr.477.1.S1 at -1.94642 -2.66204 -2.9459 -2.13349 1 0.187886 0.096 0.950415 0.096 im:7157373 im:7157373------Dr.4773.1.A1_at -1.14414 -1.07459 1.09369 3.127103 1 1 1 0.069767 0.0698 si:ch211-242m18.4 si:ch211-24--- cell cycle /// mitosis /// mitotic cell cycle checkpoint /// cell --- condensed chromosome kinetochore division Dr.478.1.S1_at -1.72372 -2.4256 -2.32659 -1.9514 1 0.841 0.934 0.999955 0.841 fgf8a fibroblast g--- cell fate specification /// cell fate specification /// growth factor activity extracellular space /// lysosome somitogenesis /// determination of left/right symmetry /// brain development /// peripheral nervous system development /// endoderm development /// endoderm development /// mesoderm development /// embryonic pattern specification /// organ morphogenesis /// anterior/posterior pattern formation /// anterior/posterior pattern formation /// dorsal/ventral pattern formation /// dorsal/ventral pattern formation /// dorsal/ventral pattern formation /// rhombomere 5 development /// rhombomere 6 development /// cerebellum formation /// locus ceruleus development /// positive regulation of Wnt receptor signaling pathway /// neuron differentiation /// positive regulation of cell migration /// thyroid gland development /// midbrain development /// midbrain development /// hindbrain development /// hindbrain development /// notochord development /// otic vesicle formation /// otic vesicle formation /// otic vesicle formation /// midbrain-hindbrain boundary development /// embryonic camera-type eye development /// embryonic heart tube development /// negative regulation of endodermal cell fate specification /// negative regulation of endodermal cell fate specification /// otic placode formation /// otic placode formation /// regulation of bone remodeling /// regulation of bone remodeling /// determination of dorsal identity /// paraxial mesoderm development /// neuron fate specification /// skeletal morphogenesis /// oligodendrocyte differentiation /// inner ear development /// striated muscle cell differentiation /// cartilage development /// pharyngeal system development /// retina development in camera-type eye Dr.4782.1.S1_at 1.334079 1.688875 1.446589 2.347299 1 1 1 0.61841 0.6184 ctsc cathepsin C--- proteolysis cysteine-type endopeptidase activity /// endopeptidase --- inhibitor activity /// peptidase activity /// cysteine-type peptidase activity /// hydrolase activity Dr.4787.1.A1 at 2.052274 2.508364 2.188179 2.142383 0.999955 0.755903 0.958523 0.98838 0.7559 larp1 La ribonucl------heme binding /// transition metal ion binding --- Dr.4794.1.A1_at 1.798785 2.20596 2.096111 1.259839 1 0.931661 0.998961 1 0.9317 zgc:66117 zgc:66117 --- nucleotide metabolic process nucleotide binding /// magnesium ion binding /// 5'- cytoplasm nucleotidase activity /// transferase activity /// hydrolase activity /// metal ion binding Dr.4794.2.S1_at 1.495319 2.262029 1.912715 1.108456 1 0.671 1 1 0.671 zgc:66117 zgc:66117 --- nucleotide metabolic process nucleotide binding /// magnesium ion binding /// 5'- cytoplasm nucleotidase activity /// transferase activity /// hydrolase activity /// metal ion binding Dr.4796.1.A1_at 1.516872 2.679869 2.721773 2.721733 1 0.715218 0.823937 0.668673 0.6687 casp3a caspase 3, --- proteolysis /// apoptosis /// apoptosis /// response to endopeptidase inhibitor activity /// peptidase activity /// --- chemical stimulus /// positive regulation of apoptosis peptidase activity /// cysteine-type peptidase activity /// hydrolase activity Dr.4799.1.A1 at 2.072069 2.776891 3.367341 2.193075 0.955674 0.417141 0.099986 0.739984 0.1 wdr36 WD repeat --- rRNA processing --- small-subunit processome Dr.4805.1.S1 at 1.163999 1.52647 1.670064 2.052755 1 1 1 0.999 0.999 zgc:171444 zgc:171444------Dr.4820.1.S1 at 1.529921 1.91512 2.227945 1.84057 1 1 0.348657 1 0.3487 fxr1 fragile X me------RNA binding --- Dr.4828.2.A1 at 2.333476 5.07841 4.647796 3.33191 0.890884 0.109969 0.159913 0.702993 0.11 arf1 ADP-ribosy--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.4829.1.A1_at 3.277645 2.372315 2.266818 2.220461 0.170965 0.210693 0.755615 0.602 0.171 alas1 aminolevuli--- metabolic process /// biosynthetic process /// tetrapyrrole catalytic activity /// 5-aminolevulinate synthase activity /// --- biosynthetic process transferase activity /// transferase activity, transferring nitrogenous groups /// pyridoxal phosphate binding

Dr.4832.1.A1 at -1.22204 -1.77684 -2.10845 -2.20418 1 1 0.992 0.760656 0.7607 si:dkeyp-93c5.1 si:dkeyp-93------Dr.4833.2.S1 at -1.60694 -1.40419 -1.33053 6.658275 1 1 1 0.058694 0.0587 mad2l1 MAD2 mito--- mitosis ------Dr.4833.3.A1 a at -1.11562 1.019869 1.137129 5.583632 1 1 1 0.091344 0.0913 krcp kelch repea------Dr.4833.7.S1 at -1.98094 -2.63881 -2.45758 -1.85209 1 0.238637 0.402696 1 0.2386 LOC100151347 hypothetica------Dr.4833.8.S1 at -1.43349 -1.1145 1.056921 2.332794 1 1 1 0.671171 0.6712 cenpk SoxLZ/Sox------Dr.4846.1.S1 at 1.352301 2.305112 2.820009 2.846439 1 0.936556 0.597473 0.604 0.5975 pa2g4a proliferation--- proteolysis metalloexopeptidase activity --- Dr.486.1.S1 at 1.325 1.610371 2.372245 2.719761 1 1 0.92 0.486 0.486 ppp1r14b protein pho--- regulation of phosphorylation protein binding cytoplasm Dr.4868.1.A1 at 3.283738 3.022719 2.062168 1.907354 0.26362 0.275521 0.999917 1 0.2636 zgc:174888 zgc:174888------Dr.4869.1.A1 at 1.91557 2.628376 2.885433 3.904938 1 0.221 0.134354 0.104819 0.1048 im:7149020 im:7149020------hedgehog receptor activity membrane Dr.4875.1.A1 at -1.22411 -1.75302 -2.18161 -2.24051 1 1 0.921541 0.84 0.84 si:ch211-93f2.1 si:ch211-93------hydrolase activity --- Dr.4877.1.S1_at -1.24127 1.179201 1.595548 2.002839 1 1 1 0.992731 0.9927 chek2 CHK2 chec--- protein amino acid phosphorylation protein kinase activity /// protein serine/threonine kinase --- activity /// ATP binding /// kinase activity Dr.4878.1.S1 at -3.59278 -2.13423 -4.06335 -1.74898 0.993617 0.999917 0.959 1 0.959 si:dkey-238c7.13 si:dkey-238------Dr.4881.1.A1 at 2.075363 3.298074 3.229598 2.390024 0.955 0.521669 0.66833 0.671552 0.5217 wu:fb48h07 wu:fb48h07------Dr.4887.1.A1 at 2.724205 1.672074 1.13515 2.171207 0.361812 1 1 0.958085 0.3618 ------Dr.4899.1.A1_at -1.52566 -2.05789 -2.52238 -2.79229 1 0.99 0.028331 0.025676 0.0257 gstr1 /// tfa Rho-class --- iron ion transport /// cellular iron ion homeostasis /// ferric iron binding /// transferase activity extracellular region response to bacterium Dr.4905.1.S1_at -2.91924 -6.21681 -6.07577 -5.62637 0.15124 0.018746 0.010159 0.014588 0.0102 ucp4 uncoupling --- transport /// mitochondrial transport transporter activity /// binding mitochondrion /// mitochondrial inner membrane /// membrane /// integral to membrane Dr.4911.1.A1 at 1.584613 2.445996 1.391248 1.287772 1 0.028767 1 1 0.0288 zgc:92000 zgc:92000 --- glycolipid transport glycolipid transporter activity /// glycolipid binding cytoplasm Dr.4927.1.A1 at 1.115722 -1.96506 -2.80786 -2.3365 1 0.999955 0.683 0.930374 0.683 wu:fb77g05 wu:fb77g05------Dr.4938.1.S1_at -3.03454 -5.20836 -7.01321 -5.88033 0.497497 0.045165 0.011671 0.014037 0.0117 fads2 fatty acid d--- lipid metabolic process /// fatty acid biosynthetic process /// iron ion binding /// oxidoreductase activity /// oxidoreductase endoplasmic reticulum /// endoplasmic transport /// lipid biosynthetic process /// oxidation reduction activity, acting on paired donors, with oxidation of a pair of reticulum membrane /// membrane /// integral donors resulting in the reduction of molecular oxygen to two to membrane molecules of water /// heme binding /// transition metal ion binding Dr.4943.1.S1 at 2.180044 1.865122 1.665373 1.609215 0.78162 1 1 1 0.7816 eif1b eukaryotic t--- translation /// translational initiation translation initiation factor activity --- Dr.4975.1.A1 at 1.418373 2.912308 3.3845 5.783027 1 0.600275 0.35 0.072781 0.0728 wu:fb99e11 wu:fb99e11------Dr.4983.1.S1_at 1.061528 -1.66161 -2.39359 -2.22309 1 1 0.456256 0.86778 0.4563 gpx4a glutathione --- response to oxidative stress /// oxidation reduction peroxidase activity /// glutathione peroxidase activity /// --- selenium binding /// oxidoreductase activity /// phospholipid- hydroperoxide glutathione peroxidase activity

Dr.4986.1.S1_at 2.458127 3.033873 2.513775 2.45611 0.639592 0.281594 0.627951 0.643439 0.2816 txnrd1 thioredoxin --- cell redox homeostasis /// oxidation reduction selenium binding /// electron carrier activity /// protein cytoplasm disulfide oxidoreductase activity /// oxidoreductase activity /// oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor /// FAD binding /// NADP binding

Dr.5000.1.A1 at -1.63549 -1.68603 -2.70791 -2.48047 1 1 0.517457 0.462739 0.4627 ------Dr.5005.1.A1 at 1.0116 1.453056 1.652266 4.135869 1 1 1 0.278605 0.2786 wu:fc15d06 wu:fc15d06------Dr.5005.2.S1 at 1.478136 2.245557 2.253659 5.128123 1 0.725185 0.848396 0.047792 0.0478 wu:fb95e12 wu:fb95e12------Dr.5008.1.S1 at 1.349431 2.16994 2.001535 1.443658 1 0.987827 1 1 0.9878 zgc:92045 zgc:92045 ------Dr.5018.1.A1_at 3.310656 4.205703 3.302099 2.868165 0.024718 0.023258 0.040706 0.053521 0.0233 dusp11 dual specif--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein --- tyrosine/serine/threonine phosphatase activity /// hydrolase activity /// phosphatase activity Dr.502.1.S1 at 2.235248 2.084859 1.912232 1.005612 0.799398 1 1 1 0.7994 si:dkey-22a1.3 si:dkey-22a------Dr.5025.1.S1 at -1.76677 -2.9243 -2.88626 -2.47901 1 0.695447 0.585215 0.773 0.5852 ------Dr.504.1.S1_at 2.277422 3.082969 3.412237 2.447546 0.846 0.088304 0.170513 0.474 0.0883 ergic3 ERGIC and --- transport /// vesicle-mediated transport --- endoplasmic reticulum /// endoplasmic reticulum membrane /// Golgi apparatus /// membrane /// integral to membrane /// ER- Golgi intermediate compartment membrane

Dr.5040.1.S1 at 2.93261 4.411214 2.796574 2.44661 0.254351 0.080856 0.294771 0.747252 0.0809 cyb5a cytochrome ------heme binding /// transition metal ion binding --- Dr.5045.2.A1 at 1.487883 2.104725 2.546165 1.969045 1 0.982513 0.339209 0.999 0.3392 mrpl19 mitochondr--- translation structural constituent of ribosome intracellular /// ribosome Dr.5047.1.A1 at 2.783601 4.238065 3.338586 2.688926 0.309832 0.062146 0.170576 0.427695 0.0621 wu:fc01e05 wu:fc01e05------Dr.5054.2.S1 at -1.51247 -2.36986 -1.50656 -2.01192 1 0.978485 1 0.998 0.9785 ------Dr.5060.1.A1 at -1.46694 -2.37547 -2.24624 -3.72529 1 0.774703 0.466593 0.038499 0.0385 ------Dr.5081.1.A1_at -2.63833 -2.90492 -3.43773 -4.03463 0.850534 0.346238 0.145727 0.095869 0.0959 zgc:110784 zgc:110784--- metabolic process catalytic activity /// molybdenum ion binding /// pyridoxal --- phosphate binding Dr.5091.1.S1_at -1.14343 1.150208 4.49912 8.146122 1 1 0.09053 0.034461 0.0345 mcm4 MCM4 min --- DNA replication initiation nucleotide binding /// DNA binding /// ATP binding /// nucleus nucleoside-triphosphatase activity Dr.5094.3.A1 at 1.205473 2.091423 2.263228 2.269255 1 0.9997 1 0.861 0.861 ------Dr.5098.1.S1_at 1.415764 2.471816 2.851192 3.865031 1 0.667478 0.231675 0.036473 0.0365 rpl35 ribosomal p--- translation /// cell cycle /// multicellular organismal structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein development /// negative regulation of cell cycle complex Dr.5112.1.S3 at -1.0475 1.036294 1.559213 2.647758 1 1 1 0.44277 0.4428 sox11b SRY-box c--- regulation of transcription, DNA-dependent DNA binding --- Dr.5123.1.A1 at 1.893128 2.546904 2.599902 2.457186 1 0.322 0.540313 0.479177 0.322 tjp2b tight junctio------protein binding --- Dr.5129.1.S1 at -4.74799 -3.67151 -3.09897 -2.58629 0.056294 0.355 0.348 0.50339 0.0563 sesn3 sestrin 3 --- cell cycle arrest --- nucleus Dr.5151.1.A1 at 2.202094 2.275209 2.776481 3.995758 0.974 0.99934 0.935 0.118635 0.1186 ptprn2l protein tyro------Dr.5169.1.A1 at 1.69118 2.409725 2.409042 1.91395 1 0.809779 0.797642 1 0.7976 wu:fc20c02 wu:fc20c02------Dr.5170.2.A1 at -1.62705 -1.74771 -2.28057 -1.4875 1 1 0.756 1 0.756 wu:fc41e04 wu:fc41e04------Dr.5185.1.A1_at -1.09346 1.948474 2.011092 1.679985 1 1 0.996244 1 0.9962 iars isoleucyl-tR--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm isoleucyl-tRNA aminoacylation isoleucine-tRNA ligase activity /// ATP binding Dr.519.1.A1_at -1.37372 -1.13845 1.313582 3.518201 1 1 1 0.404661 0.4047 pola1 polymerase --- nucleobase, nucleoside, nucleotide and nucleic acid nucleotide binding /// nucleic acid binding /// DNA binding /// nucleus metabolic process /// DNA replication DNA-directed DNA polymerase activity /// transferase activity /// nucleotidyltransferase activity Dr.5192.1.A1_at -1.5461 -1.48521 -1.82475 -2.10901 1 1 1 0.999 0.999 nr2e1 nuclear rec--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// steroid binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.5205.1.A1 at -1.83132 -1.83014 -1.98776 -2.00285 1 1 1 0.998 0.998 wu:fc32b06 wu:fc32b06------Dr.5206.1.S1_at -1.40527 -1.38479 -1.62652 -2.04937 1 1 1 0.995 0.995 aldh1a2 aldehyde d --- determination of left/right symmetry /// metabolic process /// oxidoreductase activity --- anterior/posterior pattern formation /// myelination in the central nervous system /// myelination in the peripheral nervous system /// pancreas development /// retinol metabolic process /// retinoic acid metabolic process /// gut morphogenesis /// pronephros development /// oxidation reduction Dr.5208.1.A1_at 2.501811 2.695502 2.503194 1.868247 0.647744 0.552867 0.168277 1 0.1683 timm50 translocase --- protein amino acid dephosphorylation /// transport /// protein serine/threonine phosphatase activity /// protein mitochondrion /// mitochondrial inner apoptosis /// mitochondrial membrane organization and tyrosine phosphatase activity /// protein binding /// membrane /// mitochondrial inner membrane biogenesis /// protein transport /// intracellular protein phosphatase activity /// mitochondrial inner membrane presequence transport across a membrane translocase complex /// membrane /// integral to membrane

Dr.5216.1.S1 at -2.46817 -2.57826 -2.1059 -1.77423 0.868 0.396709 0.763556 1 0.3967 LOC100150763 /// znf395 similar to z------Dr.5226.1.S1_at 1.302777 2.069243 2.075535 1.484785 1 0.998 0.999917 1 0.998 picalm phosphatid--- clathrin coat assembly nucleotide binding /// motor activity /// actin binding /// protein myosin complex /// clathrin coat binding /// ATP binding /// phospholipid binding /// phosphatidylinositol binding /// clathrin binding /// actin filament binding Dr.5231.1.S1 at -2.30726 -3.22212 -2.59915 -2.22597 0.846 0.285736 0.728712 0.87 0.2857 hist2h2l histone 2, H--- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.5258.1.A1 at 2.207491 10.1954 11.31016 17.37792 0.852348 0.008826 0.012074 0.008954 0.0088 Stra6 /// zgc:136689 Stra6 prote--- embryonic development ------Dr.5259.1.S1_at 1.619776 2.137172 1.885529 1.698267 1 0.60981 1 1 0.6098 arcn1 archain 1 --- transport /// intracellular protein transport /// vesicle- protein binding clathrin adaptor complex mediated transport Dr.5264.1.A1 at -1.76157 -1.99459 -2.7959 -2.24368 1 1 0.554804 0.608475 0.5548 LOC100005518 similar to P------Dr.5266.1.A1 at -2.42238 -1.2302 -1.62152 -1.35214 0.711231 1 1 1 0.7112 wu:fc54d09 wu:fc54d09------Dr.5269.2.A1 a at -1.6035 -1.88129 -1.69691 -2.34118 1 1 1 0.801 0.801 ------Dr.5293.1.S1 at 1.799651 2.287004 2.31746 3.862675 1 0.910464 0.90448 0.112 0.112 hn1l hematologi------Dr.5294.1.S1_at 2.269728 2.576574 2.1285 1.714576 0.907435 0.60822 0.998 1 0.6082 eif4e1a eukaryotic t--- translation /// translational initiation /// translational initiation RNA 7-methylguanosine cap binding /// RNA binding /// nucleus /// nucleus /// cytoplasm /// cytoplasm /// translational initiation /// regulation of translation translation initiation factor activity /// translation initiation factor activity /// translation initiation factor activity /// protein binding Dr.53.1.S1_at 2.037109 2.559404 2.23796 3.065061 1 0.7 0.863525 0.176719 0.1767 cse1l chromosom--- protein import into nucleus, docking /// transport /// binding /// importin-alpha export receptor activity /// protein nucleus /// nuclear pore /// cytoplasm intracellular protein transport /// cell proliferation /// protein transporter activity transport Dr.5307.1.S1_at 3.463177 4.11673 3.563057 3.85478 0.299 0.141334 0.365192 0.187178 0.1413 slc20a1b solute carri--- transport /// phosphate transport inorganic phosphate transmembrane transporter activity /// membrane /// integral to membrane symporter activity Dr.5312.1.S1_at -1.09926 -1.77213 -2.13931 -2.30589 1 1 0.99934 0.923812 0.9238 abat 4-aminobut--- gamma-aminobutyric acid metabolic process catalytic activity /// 4-aminobutyrate transaminase activity /// --- transaminase activity /// transferase activity /// pyridoxal phosphate binding Dr.5335.2.S1_at 2.177344 2.792871 2.80807 3.569738 0.994863 0.71 0.53587 0.185697 0.1857 top1l topoisomer--- DNA topological change /// DNA unwinding during DNA binding /// DNA topoisomerase type I activity /// DNA chromosome replication topoisomerase (ATP-hydrolyzing) activity /// isomerase activity Dr.5338.1.A1 at -1.11237 -1.05629 1.030915 4.213794 1 1 1 0.079307 0.0793 si:busm1-142b24.1 si:busm1-1 ------DNA binding --- Dr.5342.1.A1 at 2.722714 4.664967 5.723867 6.342335 0.847945 0.070797 0.045 0.056117 0.045 hspb8 Heat shock ------Dr.5350.1.A1 at 1.096023 1.503159 1.533717 2.547326 1 1 1 0.790793 0.7908 edc3 Enhancer o------cytoplasm Dr.5351.1.A1 at 3.413242 2.108696 1.905275 2.384805 0.386645 0.993617 1 0.750407 0.3866 CH211-218O21.5 hypothetica------Dr.5356.1.A1 at 2.950899 1.975958 2.063321 1.552699 0.746211 1 0.999955 1 0.7462 zgc:153073 zgc:153073------Dr.5365.1.A1_at 1.144795 2.424814 2.400609 1.04871 1 0.35268 0.398183 1 0.3527 dusp5 dual specif--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// protein --- tyrosine/serine/threonine phosphatase activity /// hydrolase activity /// phosphatase activity /// MAP kinase tyrosine/serine/threonine phosphatase activity Dr.5371.1.A1 at 2.50084 3.534854 3.647715 2.152716 0.566991 0.358158 0.140516 0.99994 0.1405 tsr1 TSR1, 20S --- ribosome biogenesis --- nucleus Dr.5372.1.S1_x_at -1.19082 -1.10126 1.370035 2.105805 1 1 1 0.908535 0.9085 her4.2 hairy-relate--- somite specification /// transcription /// transcription DNA binding /// double-stranded DNA binding /// nucleus termination /// regulation of transcription, DNA-dependent /// transcription regulator activity Notch signaling pathway /// anterior/posterior pattern formation /// transcription antitermination /// regulation of transcription Dr.5372.7.A1_at -4.46463 -3.77057 -2.24699 -1.30086 0.63694 0.383959 0.947 1 0.384 CH73-21G5.3 novel prote--- transcription /// regulation of transcription, DNA-dependent DNA binding /// transcription regulator activity nucleus /// regulation of transcription Dr.5372.7.A1_x_at -3.78363 -3.07956 -1.86456 -1.19754 0.81946 0.455457 1 1 0.4555 CH73-21G5.3 novel prote--- transcription /// regulation of transcription, DNA-dependent DNA binding /// transcription regulator activity nucleus /// regulation of transcription Dr.5378.1.S1 at 1.561304 2.681036 3.19848 2.597514 1 0.058428 0.141674 0.11 0.0584 sf3b3 splicing fac--- mRNA processing /// RNA splicing nucleic acid binding nucleus /// spliceosome Dr.5379.1.A1_at 2.080322 1.802161 1.538991 1.297031 0.946 1 1 1 0.946 sox2 SRY-box c--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity nucleus /// transcription factor complex /// transcription, DNA-dependent /// multicellular organismal cytoplasm development /// transcription antitermination /// eye morphogenesis /// positive regulation of transcription factor activity Dr.539.1.S1_at -3.60724 -4.11792 -3.3133 -3.28718 0.396906 0.320323 0.480544 0.53 0.3203 rx2 retinal hom--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription, DNA-dependent /// multicellular organismal specific DNA binding development /// transcription antitermination /// regulation of transcription Dr.539.1.S1_s_at -2.83114 -3.17321 -2.60505 -2.98397 0.193313 0.175373 0.437275 0.217647 0.1754 rx2 retinal hom--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription, DNA-dependent /// multicellular organismal specific DNA binding development /// transcription antitermination /// regulation of transcription Dr.5392.1.S1 at 1.471381 2.323233 2.932877 3.535466 1 0.888891 0.050978 0.158248 0.051 LOC557270 hypothetica------Dr.5393.1.A1_at 1.974553 2.065997 1.563132 1.164355 1 0.99934 1 1 0.9993 LOC558466 similar to U --- metabolic process nucleotide binding /// ATP binding /// kinase activity /// --- transferase activity /// phosphotransferase activity, alcohol group as acceptor Dr.5403.1.A1 at 2.089754 2.432609 2.238023 1.824519 0.99934 0.818909 0.880601 1 0.8189 dnttip2 deoxynucle ------Dr.5413.1.A1 at -2.53171 -1.06236 -1.64461 -1.75387 0.737 1 1 1 0.737 wu:fc93h12 wu:fc93h12------Dr.5432.1.A1 at -1.27095 -1.21096 1.053 2.967579 1 1 1 0.67748 0.6775 wu:fb54e10 wu:fb54e10------Dr.5433.1.A1 at -1.34982 -2.2982 -2.27857 -2.44587 1 0.99934 0.99934 0.996758 0.9968 wu:fd13g09 wu:fd13g09------Dr.5434.10.S1_at 1.478079 3.038105 3.731226 4.529424 1 0.3423 0.077887 0.036178 0.0362 zgc:92872 zgc:92872 --- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.5434.2.A1 a at -2.87971 -2.79621 -2.29839 -2.46073 0.740392 0.855387 0.981819 0.958399 0.7404 plp1b proteolipid ------Dr.5434.5.S1 a at -1.43689 -2.71463 -4.30548 -3.52536 1 0.094107 0.037196 0.044418 0.0372 gpm6ab glycoprotei------Dr.5434.6.S1 at -1.47267 -1.69705 -2.6905 -2.37832 1 1 0.307 0.457346 0.307 gpm6ba glycoprotei------Dr.5435.1.S1 at 2.262628 2.437128 2.088834 2.144303 0.947593 0.899558 0.999917 0.992263 0.8996 eif5 eukaryotic t--- translational initiation translation initiation factor activity /// binding --- Dr.5438.1.S1 at 1.451718 1.853899 1.944354 2.181925 1 1 1 0.581419 0.5814 arf1l ADP-ribosy--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.5452.1.S1 at 1.658893 2.677273 2.155365 2.108638 1 0.22821 0.99 0.980838 0.2282 prpf8 pre-mRNA --- nuclear mRNA splicing, via spliceosome --- spliceosome Dr.5464.1.S1 at 2.35184 2.315204 2.619999 2.206646 0.994696 0.981543 0.591443 0.998 0.5914 wu:fb10c11 wu:fb10c11------Dr.5470.1.A1_at 1.037246 1.327219 1.510954 2.085071 1 1 1 0.848721 0.8487 rqcd1 RCD1 requ--- transcription /// transcription termination /// regulation of --- nucleus transcription, DNA-dependent /// transcription antitermination Dr.5477.1.S1 at 1.031629 -1.32988 -2.11135 -2.97126 1 1 0.952481 0.0951 0.0951 ptma prothymosi------nucleus Dr.5485.3.S1 at -1.29575 -2.04 -2.467 -2.5145 1 1 0.996557 0.993617 0.9936 ------Dr.5491.1.S1 at 1.582978 2.155571 1.847013 1.875675 1 0.99934 1 1 0.9993 ------Dr.5495.1.S1_at 2.500813 4.348467 3.578784 2.989043 0.783315 0.153167 0.325209 0.517954 0.1532 pax2b paired box --- transcription /// transcription termination /// regulation of DNA binding nucleus transcription, DNA-dependent /// multicellular organismal development /// transcription antitermination /// regulation of transcription Dr.5495.2.A1 at 2.537299 4.093353 3.336484 2.713512 0.71 0.055018 0.134313 0.465415 0.055 wu:fb81e09 wu:fb81e09------Dr.5496.1.S1 at 1.619724 3.693569 3.304119 3.927039 1 0.060597 0.076602 0.033407 0.0334 sec13 SEC13 hom------Dr.5498.1.S1_at 1.438972 2.892669 3.109936 2.718235 1 0.023179 0.020431 0.163807 0.0204 ppid peptidylpro--- protein folding peptidyl-prolyl cis-trans isomerase activity /// binding /// --- isomerase activity Dr.5499.1.S1_at 1.29727 1.659885 1.537965 2.40049 1 1 1 0.852348 0.8523 zgc:65824 zgc:65824 --- transport /// intracellular protein transport /// protein protein binding /// protein binding /// protein transporter membrane coat /// clathrin coat of trans-Golgi transport /// vesicle-mediated transport activity network vesicle /// clathrin adaptor complex

Dr.5506.1.A1 at 1.991031 3.149488 2.772421 2.624206 1 0.142633 0.354354 0.457544 0.1426 LOC100149263 /// pa2g4bhypothetica--- proteolysis metalloexopeptidase activity --- Dr.5513.1.S1 at -1.91608 -1.47381 -2.44362 -3.41994 1 1 0.758 0.269635 0.2696 slc3a2 solute carri--- carbohydrate metabolic process catalytic activity /// cation binding --- Dr.5522.1.S1_at 4.715265 6.508253 7.062493 6.353335 0.064528 0.043943 0.031565 0.031526 0.0315 LOC100149141 /// nolc1l similar to N--- nucleosome assembly /// homoiothermy /// response to DNA binding /// ice binding nucleosome /// nucleus freezing Dr.5529.1.S1 at 1.62727 2.347305 2.016707 2.660149 1 0.92588 0.9997 0.344864 0.3449 gdi2 GDP disso--- protein transport /// regulation of GTPase activity Rab GDP-dissociation inhibitor activity --- Dr.5536.1.A1_at -2.8963 -2.68567 -2.35489 -2.01845 0.587855 0.593209 0.939682 0.99934 0.5879 si:dkey-33k14.4 si:dkey-33k ------nucleic acid binding /// NAD+ ADP-ribosyltransferase nucleus activity /// zinc ion binding Dr.5541.1.S1_at 1.215263 2.368217 2.308072 2.59243 1 0.427695 0.416271 0.424437 0.4163 eif2s1 eukaryotic t--- translation RNA binding /// translation initiation factor activity eukaryotic translation initiation factor 2 complex Dr.5545.1.S1 at 1.711153 2.973423 3.336399 4.538513 1 0.72 0.423 0.149615 0.1496 zgc:136952 /// zgc:153166zgc:136952 --- translation structural constituent of ribosome intracellular /// ribosome Dr.5565.1.S1_at 1.652349 3.453473 3.959788 3.471092 1 0.524884 0.338414 0.116925 0.1169 sepm selenoprote--- negative regulation of signal transduction selenium binding signal recognition particle, endoplasmic reticulum targeting Dr.5578.2.S1_a_at 2.445782 4.043975 4.334059 5.147322 0.658 0.105323 0.042256 0.073265 0.0423 odc1 ornithine de--- polyamine biosynthetic process /// eye photoreceptor cell catalytic activity --- development Dr.558.1.S1_at 2.897218 1.088239 -1.12084 1.397417 0.577 1 1 1 0.577 vsx1 visual syste--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription, DNA-dependent /// multicellular organismal specific DNA binding development /// visual perception /// transcription antitermination /// regulation of transcription /// response to stimulus Dr.5581.1.S1 at 1.132946 1.828233 1.920542 2.172845 1 1 1 0.621294 0.6213 psmd4 proteasome ------cytosol /// protein complex Dr.5583.1.A1 at -1.46328 -1.86771 -1.31791 -2.44772 1 1 1 0.660637 0.6606 ------Dr.5588.1.S1 at 3.811467 5.391123 5.571412 3.984228 0.088304 0.03794 0.037179 0.088726 0.0372 hspa4l heat shock --- response to stress nucleotide binding /// ATP binding --- Dr.5594.1.S1_at 1.016357 1.691563 2.194282 2.609045 1 1 0.889832 0.241797 0.2418 p4hb /// psmb3 procollagen--- ubiquitin-dependent protein catabolic process threonine-type endopeptidase activity /// endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome inhibitor activity /// peptidase activity /// hydrolase activity core complex /// protein complex

Dr.5598.1.S1_at 3.122811 4.531367 4.345454 4.283485 0.080828 0.033814 0.057822 0.04021 0.0338 eif6 eukaryotic t--- integrin-mediated signaling pathway /// mature ribosome translation initiation factor activity /// ribosome binding --- assembly Dr.5605.1.S1_a_at 1.619349 3.759387 4.649919 5.949294 1 0.02591 0.025219 0.026222 0.0252 LOC572064 /// tubb2c tubulin beta --- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.5605.2.S1_x_at 1.706528 3.758815 4.212167 6.077615 1 0.02057 0.039268 0.016151 0.0162 LOC572064 /// tubb2c tubulin beta --- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.5605.3.S1_at -1.19758 1.011859 1.936892 5.070196 1 1 1 0.037889 0.0379 zgc:123194 zgc:123194--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.5605.3.S1_x_at -1.2456 1.084573 1.774142 4.38866 1 1 1 0.084806 0.0848 zgc:123194 zgc:123194--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule cytoplasm /// microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.5605.4.S1 at -1.40162 1.156626 -1.11447 2.432664 1 1 1 0.511526 0.5115 zgc:123210 zgc:123210--- nucleosome assembly DNA binding chromatin /// nucleosome /// nucleus Dr.5620.1.S1 at 1.685674 2.530885 3.19592 3.719737 1 0.463672 0.253705 0.063379 0.0634 pfdn5 prefoldin 5 --- protein folding unfolded protein binding prefoldin complex Dr.5621.1.A1 at 2.169111 2.982763 3.891835 6.26772 0.821 0.202762 0.087686 0.022205 0.0222 arpc5a actin relate--- regulation of actin filament polymerization --- cytoskeleton Dr.5627.1.A1_at -2.22738 -3.25228 -3.17395 -3.26892 0.469255 0.037856 0.011876 0.043317 0.0119 zgc:113338 zgc:113338--- intracellular protein transport /// endocytosis /// vesicle- protein binding clathrin adaptor complex mediated transport Dr.563.1.S1 at -1.91545 -1.9886 -1.5732 -2.66464 1 0.999955 1 0.757666 0.7577 spon2b spondin 2b ------proteinaceous extracellular matrix Dr.5635.2.S1 at -1.98431 -2.53835 -1.61028 -2.88623 0.998 0.357723 1 0.365479 0.3577 ------Dr.5639.1.S1 at -1.46971 -1.5789 -1.43363 -2.03857 1 1 1 0.999917 0.9999 mtf1 metal-regul--- response to zinc ion /// response to cadmium ion nucleic acid binding /// zinc ion binding intracellular /// nucleus /// cytoplasm Dr.5644.1.S1_at -1.99154 -2.1084 -1.7101 -2.06683 1 0.99994 1 1 0.9999 mxi1 max interac--- transcription /// transcription termination /// regulation of DNA binding /// transcription regulator activity nucleus transcription, DNA-dependent /// transcription antitermination /// regulation of transcription Dr.5651.1.S1_at 2.521951 2.788805 2.913431 2.68533 0.257387 0.276 0.090133 0.106618 0.0901 prmt5 protein argi------methyltransferase activity /// S-adenosylmethionine- cytoplasm dependent methyltransferase activity /// transferase activity

Dr.5656.2.S1_at 1.571076 2.035662 2.133546 1.490064 1 0.998 0.999955 1 0.998 zgc:86830 Zgc:86830 --- negative regulation of signal transduction /// cell redox --- signal recognition particle, endoplasmic homeostasis reticulum targeting /// membrane /// integral to membrane Dr.5659.1.A1 at -1.56002 -1.82117 -1.48902 -2.12004 1 1 1 0.993617 0.9936 zgc:92174 Zgc:92174 ------membrane /// integral to membrane Dr.5661.1.S1 at 1.459468 2.150348 1.926511 2.096952 1 0.592273 1 0.807425 0.5923 zgc:56304 zgc:56304 --- transport nucleotide binding /// nucleic acid binding intracellular Dr.5663.1.S1 at -1.46252 -1.78793 -1.26423 -2.33492 1 1 1 0.580362 0.5804 ------Dr.5673.1.S1 at -1.59708 -2.19924 -1.52431 -2.89205 1 0.986 1 0.333356 0.3334 wu:fb36g02 wu:fb36g02------Dr.5677.1.S1 at 5.350309 7.644565 10.83682 13.97929 0.032497 0.017836 0.011536 0.010741 0.0107 c6orf115 chromosom------Dr.5678.1.S1_at 1.279908 -1.09734 -1.4271 -2.27448 1 1 1 0.808757 0.8088 cav1 caveolin 1 --- somitogenesis /// heart development /// cholesterol --- Golgi membrane /// Golgi apparatus /// absorption /// neuromast development /// notochord cell membrane /// integral to membrane vacuolation Dr.5678.1.S1_s_at 1.37454 -1.17247 -1.62932 -2.47659 1 1 1 0.481552 0.4816 cav1 caveolin 1 --- somitogenesis /// heart development /// cholesterol --- Golgi membrane /// Golgi apparatus /// absorption /// neuromast development /// notochord cell membrane /// integral to membrane vacuolation Dr.5685.1.S1 at -1.53641 -1.8518 -1.59041 -2.56018 1 1 1 0.339121 0.3391 ------Dr.5690.1.S1 at -2.46955 -1.81275 -2.14811 -1.01176 0.678529 1 0.987681 1 0.6785 wu:fc59b06 wu:fc59b06------Dr.5701.1.S1 at 3.307434 4.134639 3.981898 2.948846 0.475935 0.137 0.085785 0.25587 0.0858 zgc:56683 zgc:56683 --- negative regulation of signal transduction --- nucleus /// membrane Dr.5702.1.A1 at -1.32704 -1.88011 -2.41161 -2.1263 1 1 0.582416 0.953 0.5824 wu:fi56h12 wu:fi56h12 ------Dr.5704.1.S1 at -1.232 -1.69 -2.22223 -2.41087 1 1 0.629 0.392327 0.3923 LOC795029 /// zgc:73311 hypothetica------Dr.5705.1.S1_at 1.037822 2.294443 2.862903 3.824599 1 0.640137 0.070902 0.016257 0.0163 rps3 ribosomal p--- translation RNA binding /// structural constituent of ribosome intracellular /// ribosome /// small ribosomal subunit /// ribonucleoprotein complex Dr.5707.1.S1 at 1.078366 1.582794 1.790986 2.100644 1 1 1 0.957332 0.9573 zgc:92635 zgc:92635 --- ubiquitin-dependent protein catabolic process protein binding --- Dr.571.1.S1_at -1.69476 -2.0964 -1.74455 -2.68152 1 0.999955 1 0.849 0.849 tll1 tolloid-like 1--- blood vessel development /// mesoderm formation /// endopeptidase inhibitor activity /// calcium channel activity /// extracellular region /// signal recognition endothelial cell development /// proteolysis /// proteolysis /// calcium ion binding /// metalloendopeptidase inhibitor activity particle, endoplasmic reticulum targeting calcium ion transport /// zinc ion transport /// multicellular /// peptidase activity /// peptidase activity /// metallopeptidase organismal development /// dorsal/ventral pattern formation activity /// metallopeptidase activity /// zinc ion binding /// zinc /// dorsal/ventral pattern formation /// negative regulation of ion binding /// hydrolase activity /// calcium channel inhibitor signal transduction /// positive regulation of BMP signaling activity /// metal ion binding pathway /// embryonic caudal fin morphogenesis /// embryonic hemopoiesis /// determination of ventral identity /// determination of ventral identity

Dr.5711.1.S1 at -1.56723 -2.21803 -1.34486 -2.47909 1 0.919 1 0.73037 0.7304 arhgdig Rho GDP d------Rho GDP-dissociation inhibitor activity cytoplasm Dr.5715.1.S1 at -1.62169 -2.1083 -1.37075 -2.26606 1 0.99263 1 0.936639 0.9366 LOC796684 hypothetica------Dr.5723.1.S1_s_at -1.9128 -2.31 -1.24767 -2.26803 1 0.636293 1 0.902772 0.6363 hoxb8a homeo box --- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription, DNA-dependent /// multicellular organismal specific DNA binding development /// transcription antitermination /// regulation of transcription Dr.5738.1.S1 at 2.217282 -1.59894 -2.24214 -2.09683 0.992 1 0.979 0.996927 0.979 irbp interphotore--- proteolysis receptor activity /// serine-type peptidase activity --- Dr.5757.1.S1_at -2.60605 -7.12079 -7.88747 -3.83349 0.741181 0.018592 0.010077 0.184589 0.0101 cyp26a1 cytochrome --- blood vessel development /// somitogenesis /// heme monooxygenase activity /// iron ion binding /// retinoic acid 4- endoplasmic reticulum /// endoplasmic biosynthetic process /// iron ion transport /// cellular iron ion hydroxylase activity /// electron carrier activity /// reticulum membrane /// microsome /// homeostasis /// rhombomere 4 morphogenesis /// oxidoreductase activity /// heme binding /// metal ion binding membrane rhombomere 4 morphogenesis /// forebrain anterior/posterior pattern formation /// hindbrain development /// hindbrain development /// response to chemical stimulus /// retinoic acid metabolic process /// retinoic acid metabolic process /// retinal metabolic process /// brain morphogenesis /// oxidation reduction Dr.5760.1.S1_at -1.76917 -1.79685 -1.40068 -2.14622 1 1 1 0.994659 0.9947 acvr1b activin A re--- endoderm formation /// endoderm formation /// mesoderm nucleotide binding /// protein kinase activity /// protein membrane formation /// protein amino acid phosphorylation /// serine/threonine kinase activity /// transmembrane receptor transmembrane receptor protein serine/threonine kinase protein serine/threonine kinase activity /// protein tyrosine signaling pathway /// endodermal cell fate determination /// kinase activity /// receptor activity /// transforming growth dorsal/ventral pattern formation /// fin regeneration factor beta receptor activity /// ATP binding /// kinase activity /// transferase activity Dr.5765.1.S1_at 1.071351 1.943119 2.132026 1.911183 1 0.997562 0.998 1 0.9976 rtk6 eph-like rec--- protein amino acid phosphorylation /// transmembrane nucleotide binding /// protein kinase activity /// protein membrane /// integral to membrane receptor protein tyrosine kinase signaling pathway tyrosine kinase activity /// receptor activity /// ephrin receptor activity /// ATP binding /// electron carrier activity /// kinase activity /// transferase activity Dr.5776.1.S1_at -1.52163 -1.78526 -1.37708 -2.12407 1 1 1 0.941523 0.9415 mapk12 mitogen-ac--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein cytoplasm serine/threonine kinase activity /// MAP kinase activity /// ATP binding /// kinase activity /// transferase activity Dr.578.2.S1_a_at -1.83163 -2.03765 -1.76297 -1.94815 1 0.99994 1 1 0.9999 tef thyrotroph e--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.5785.1.S1_at -1.73476 -1.81875 -1.38535 -2.0307 1 1 1 0.99994 0.9999 ntn1b netrin 1b --- dendrite development protein binding extracellular region /// proteinaceous extracellular matrix Dr.5797.1.A1 at 2.014053 3.082226 2.269402 1.707071 0.997562 0.375864 0.984689 1 0.3759 ------Dr.58.1.A1_at -2.99117 -2.81039 -2.52104 -2.50178 0.327 0.606836 0.805252 0.698761 0.327 zgc:73230 zgc:73230 ------protein binding /// phosphoinositide 3-kinase regulator phosphoinositide 3-kinase complex activity Dr.582.1.S1_a_at -1.29776 -1.51494 -1.85833 -2.28235 1 1 1 0.515217 0.5152 cx43 connexin 4 --- cell communication /// cell communication /// multicellular gap junction channel activity /// voltage-gated channel plasma membrane /// plasma membrane /// organismal development /// cell differentiation /// embryonic activity /// gap junction hemi-channel activity gap junction /// connexon complex /// heart tube development /// caudal fin morphogenesis /// connexon complex /// membrane /// integral to embryonic hemopoiesis membrane /// cell junction Dr.5846.1.A1_at 2.952925 3.462926 3.054663 3.316966 0.148356 0.228059 0.140425 0.160463 0.1404 atf4 activating tr--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus /// cytoplasm /// plasma membrane /// transcription, DNA-dependent /// transcription specific DNA binding /// protein dimerization activity membrane antitermination Dr.5881.1.S1 at -1.22444 -1.08733 1.207511 2.215097 1 1 1 0.556448 0.5564 zgc:77739 zgc:77739 ------Dr.5890.1.A1 at 2.196103 2.534594 2.658897 2.364128 0.599561 0.029993 0.043844 0.168347 0.03 LOC559900 similar to R------Dr.5902.1.S1 at 1.202793 1.581977 2.127888 1.649843 1 1 0.9997 1 0.9997 nat10 N-acetyltra--- metabolic process N-acetyltransferase activity /// transferase activity --- Dr.5923.1.S1 at 2.867597 3.693149 3.788609 3.61797 0.153225 0.185758 0.063111 0.021047 0.021 MGC171595 /// zgc:17149similar to D------Dr.5930.1.A1 at -2.26244 -3.95242 -3.67134 -4.78743 0.998 0.357357 0.40849 0.196149 0.1961 ------Dr.5932.1.A1 at -1.1992 -1.63112 -2.04277 -1.72915 1 1 0.997562 1 0.9976 si:dkey-181m9.10 si:dkey-181------integral to membrane Dr.5963.1.A1 at 2.27825 2.564487 2.125769 2.679111 0.671342 0.152174 0.966764 0.080671 0.0807 wu:fj38e08 wu:fj38e08 ------Dr.5964.1.A1 at -1.22357 -1.85535 -2.89868 -1.80908 1 1 0.454832 1 0.4548 wu:fj38g12 wu:fj38g12 ------Dr.5980.1.S1 at 1.186696 2.574028 2.739902 3.835085 1 0.412718 0.084 0.110502 0.084 psmd13 proteasome ------cytosol /// protein complex Dr.5980.2.A1 at 1.168059 -1.32274 -2.06983 -1.59775 1 1 0.996964 1 0.997 sv2b synaptic ve------Dr.5985.1.A1 at 1.714571 -1.27872 -2.09642 -1.59109 1 1 0.989 1 0.989 wu:fj54e12 wu:fj54e12 ------Dr.6026.1.A1 at 2.411144 2.849613 2.712273 2.377001 0.904301 0.635671 0.792839 0.956929 0.6357 si:ch211-266o5.1 si:ch211-26--- RNA metabolic process binding /// protein binding --- Dr.6052.1.A1 at -2.28099 -2.8575 -2.96167 -2.60687 0.964235 0.656172 0.390771 0.678 0.3908 LOC560157 similar to S------Dr.6058.1.A1 at 1.349726 2.199473 1.960823 1.585317 1 0.985798 0.999955 1 0.9858 zgc:92804 zgc:92804 --- regulation of ARF GTPase activity ARF GTPase activator activity /// zinc ion binding --- Dr.6069.1.S1_at 1.80908 2.096364 2.510135 1.829925 1 0.9027 0.70662 1 0.7066 bcat1 branched c--- metabolic process /// branched chain family amino acid catalytic activity /// branched-chain-amino-acid transaminase --- metabolic process activity /// transaminase activity /// transferase activity

Dr.6073.1.A1 at 1.537097 1.807506 1.910868 2.406338 1 1 1 0.102272 0.1023 LOC100000597 hypothetica--- cell cycle nucleotide binding /// protein binding /// GTP binding septin complex Dr.6082.1.A1 at 2.412114 3.082428 3.049435 2.177158 0.229481 0.094065 0.070797 0.955404 0.0708 wu:fi03f09 wu:fi03f09 ------Dr.6086.1.A1 at 2.13297 3.490589 3.169859 2.637252 0.994863 0.06021 0.112806 0.367471 0.0602 si:ch211-105d11.2 Si:ch211-1 ------membrane /// integral to membrane Dr.61.1.A1_at -1.59298 -1.75831 -3.14039 -4.1507 1 1 0.102 0.103 0.102 cxcl12b chemokine --- neuron migration /// immune response /// retinal ganglion cytokine activity /// chemokine activity extracellular region cell axon guidance /// induction of positive chemotaxis

Dr.613.1.S1 at -2.51102 -2.69664 -3.22628 -2.77231 0.914 0.877522 0.482 0.711 0.482 stom stomatin ------membrane Dr.614.1.S2_at -1.26751 -1.16491 1.414636 2.501304 1 1 1 0.817212 0.8172 zorba Orb/CPEB--- mRNA processing /// regulation of translation nucleotide binding /// nucleic acid binding /// RNA binding /// intracellular /// cytoplasm zinc ion binding Dr.615.1.S1_at 4.227704 6.387823 7.240701 5.050255 0.117623 0.023 0.023241 0.036801 0.023 six3b sine oculis --- regulation of transcription, DNA-dependent /// brain DNA binding /// transcription factor activity /// sequence- nucleus development /// regulation of transcription specific DNA binding Dr.6154.1.A1 at 3.370856 9.417712 4.466527 6.288138 0.525864 0.109379 0.128404 0.048925 0.0489 wu:fj19d05 wu:fj19d05 ------Dr.6156.1.A1 at -1.33852 -1.50416 -2.44398 -2.69283 1 1 0.148903 0.063379 0.0634 wu:fj20a04 wu:fj20a04 ------Dr.6157.1.S1 at -1.95033 -2.48771 -1.89736 -2.59767 1 0.08281 1 0.07629 0.0763 si:ch73-13b6.3 si:ch73-13b------Dr.6172.1.A1 at -4.15664 -2.95878 -2.54995 -4.00971 0.362673 0.768241 0.844 0.296 0.296 LOC567192 hypothetica------Dr.6181.1.S1 at 1.605288 2.075954 2.088565 1.3284 1 0.995 0.991811 1 0.9918 zgc:64095 zgc:64095 ------Dr.6183.1.A1 at -1.57725 -2.48391 -2.60142 -3.63931 1 0.849 0.855144 0.30966 0.3097 stmn4 Stathmin-lik--- intracellular signaling cascade ------Dr.6190.1.A1 at 2.008661 2.08602 2.370355 2.588049 1 0.99321 0.85 0.611 0.611 wu:fa98a01 /// zgc:77665 wu:fa98a01 --- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.6197.1.A1 at 1.672014 2.101723 2.08725 2.450012 1 0.999 0.997143 0.399674 0.3997 zgc:163002 zgc:163002------Dr.6203.1.A1 at -1.24247 -2.03494 -3.47403 -2.49869 1 0.999955 0.413275 0.827772 0.4133 wu:fj55b09 wu:fj55b09 ------Dr.6208.1.A1 at -1.44666 -1.67166 -2.10047 -1.04645 1 1 0.908884 1 0.9089 wu:fj58c09 wu:fj58c09 ------Dr.6223.1.A1 at 2.905979 4.418173 2.186264 1.566116 0.344421 0.041213 0.966 1 0.0412 ------Dr.6236.1.A1 at -2.32675 -2.07639 -1.12062 -1.40379 0.880254 0.99934 1 1 0.8803 wu:fd16d01 wu:fd16d01------Dr.6237.1.S1_at -1.05716 -1.07269 -1.04547 3.52404 1 1 1 0.094705 0.0947 kifc1 /// LOC561143 kinesin fam--- microtubule-based movement /// phosphoenolpyruvate- nucleotide binding /// motor activity /// microtubule motor microtubule /// microtubule associated dependent sugar phosphotransferase system activity /// sugar:hydrogen symporter activity /// ATP binding complex

Dr.6259.1.S1 at 1.612211 3.687292 2.564535 1.245425 1 0.152297 0.445 1 0.1523 nucb2b nucleobind------calcium ion binding --- Dr.6271.1.S1_at 1.572869 2.441456 2.604893 4.566663 1 0.439 0.208434 0.025448 0.0254 ppil1 peptidylpro--- protein folding peptidyl-prolyl cis-trans isomerase activity /// isomerase --- activity Dr.6285.1.S1 at -1.48359 -2.41141 -1.88344 -1.97497 1 0.840496 1 0.996879 0.8405 zgc:92732 zgc:92732 --- glycine catabolic process lipoic acid binding glycine cleavage complex Dr.6286.1.A1 at -1.66722 -1.9517 -1.49582 -2.04468 1 1 1 0.998 0.998 ------Dr.6287.1.A1 at 8.297254 18.19905 26.96904 23.02611 0.022118 0.010562 0.009738 0.009591 0.0096 wu:fd57b02 wu:fd57b02------Dr.6288.1.S1 at -1.29552 -1.92307 -2.85623 -1.95597 1 0.999955 0.105179 0.999955 0.1052 LOC792074 /// zgc:56517 hypothetica------Dr.6295.1.S1_at 1.463592 3.582181 3.976684 1.936228 1 0.232573 0.101875 1 0.1019 lmo4 LIM domain --- zinc ion transport /// forebrain development /// forebrain zinc ion binding /// metal ion binding --- development /// embryonic camera-type eye development /// embryonic camera-type eye development

Dr.6309.1.A1 at 2.554806 2.556709 2.45159 2.199499 0.436446 0.541338 0.308817 0.685566 0.3088 wu:fj68e01 wu:fj68e01 ------Dr.632.1.S1_at 1.564259 2.061127 2.263232 3.649121 1 1 0.980602 0.350585 0.3506 atp5j ATP syntha--- ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational proton-transporting two-sector ATPase mechanism /// hydrogen ion transporting ATPase activity, complex rotational mechanism Dr.6321.1.A1 at -1.61491 -1.86328 -2.24584 -2.36823 1 1 0.787 0.232884 0.2329 wu:fj34h12 wu:fj34h12 ------Dr.6328.1.A1 at 4.304099 4.578867 4.049654 2.004172 0.058945 0.044771 0.070741 1 0.0448 myo1e myosin IE ------Dr.633.1.S1_at 1.264422 2.03948 2.317296 2.732485 1 0.9997 0.526401 0.143418 0.1434 rpl13a ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// large ribosomal subunit /// ribonucleoprotein complex

Dr.6330.1.S1_at 1.777856 2.739204 2.682039 2.866723 1 0.061441 0.066665 0.036368 0.0364 ppm1g protein pho--- protein amino acid dephosphorylation magnesium ion binding /// catalytic activity /// protein serine/threonine phosphatase complex phosphoprotein phosphatase activity /// protein serine/threonine phosphatase activity /// hydrolase activity /// metal ion binding Dr.6332.1.S1 at 1.496993 3.080888 3.775131 4.540897 1 0.065251 0.106338 0.032098 0.0321 eif3h eukaryotic t------translation initiation factor activity --- Dr.6348.1.S1_at -1.36116 -2.40049 -3.74191 -4.12255 1 0.776236 0.074227 0.06116 0.0612 vil1l villin 1 like --- cytoskeleton organization and biogenesis actin binding /// heme binding /// transition metal ion binding ---

Dr.635.1.S1_at 1.174127 1.391563 1.578953 2.304758 1 1 1 0.894192 0.8942 atp5l ATP syntha--- cell adhesion /// cell-matrix adhesion /// integrin-mediated receptor activity /// binding integrin complex /// membrane /// integral to signaling pathway /// ATP synthesis coupled proton membrane /// proton-transporting two-sector transport ATPase complex /// mitochondrial membrane

Dr.6353.1.A1 at -1.88172 -3.28986 -3.59669 -2.03798 1 0.114151 0.028989 0.998 0.029 CH211-140M22.7 hypothetica------Dr.6360.1.A1 at -1.0083 1.047231 1.086644 9.965214 1 1 1 0.022717 0.0227 wu:fd16g01 wu:fd16g01------Dr.6362.1.A1 at -2.56006 -2.65957 -3.49807 -2.09024 0.801659 0.689509 0.233 0.997322 0.233 depdc6 DEP doma--- intracellular signaling cascade protein binding --- Dr.637.1.S1_at 1.287391 2.737792 2.392781 1.575515 1 0.961 0.986 1 0.961 cdh2 cadherin 2, --- cartilage condensation /// somitogenesis /// neuron migration serine-type endopeptidase inhibitor activity /// calcium signal recognition particle, endoplasmic /// calcium ion transport /// cell adhesion /// homophilic cell channel activity /// calcium ion binding /// protein binding /// reticulum targeting /// plasma membrane /// adhesion /// multicellular organismal development /// calcium channel inhibitor activity plasma membrane /// membrane /// integral to ectoderm development /// nervous system development /// membrane /// catenin complex /// presynaptic axonal fasciculation /// synaptogenesis /// brain development membrane /// peripheral nervous system development /// embryonic development /// negative regulation of signal transduction /// cardioblast differentiation /// neural tube development /// cell differentiation /// midbrain development /// hindbrain development /// embryonic pectoral fin morphogenesis /// tail morphogenesis /// tail morphogenesis /// dorsal fin morphogenesis /// tissue regeneration /// regulation of eye photoreceptor cell development /// embryonic eye morphogenesis /// axial mesoderm structural organization /// mesoderm morphogenesis /// semicircular canal morphogenesis /// dorsal convergence /// dorsal convergence /// retina development in camera-type eye /// auditory receptor cell stereocilium organization and biogenesis

Dr.6375.1.S1 at 1.6124 2.506443 2.909931 1.923512 1 0.153766 0.109776 0.999955 0.1098 c20orf24 c20orf24 h------Dr.6377.1.A1_at -1.62724 -2.21366 -1.35208 -2.54316 1 0.858806 1 0.769721 0.7697 zgc:63486 zgc:63486 ------catalytic activity /// transaminase activity /// transferase mitochondrion activity /// pyridoxal phosphate binding Dr.6382.1.A1_at 3.327602 3.010881 3.951174 2.246574 0.260216 0.478596 0.17151 0.99994 0.1715 hhip hedgehog i--- negative regulation of signal transduction /// negative catalytic activity membrane /// integral to membrane /// intrinsic regulation of signal transduction /// fin development /// to plasma membrane negative regulation of smoothened signaling pathway /// negative regulation of muscle development /// negative regulation of muscle development /// negative regulation of muscle development Dr.6397.1.S1_at -1.37264 1.506256 1.708259 2.274982 1 1 1 0.923513 0.9235 ppil4 peptidylpro--- protein folding nucleotide binding /// nucleic acid binding /// peptidyl-prolyl --- cis-trans isomerase activity /// isomerase activity Dr.6405.1.A1 at 1.050798 -2.24955 -2.36028 -3.58034 1 0.777788 0.541122 0.225167 0.2252 wu:fi36a10 wu:fi36a10 ------Dr.6416.1.A1_at -1.17323 -1.62279 -2.0932 -1.37288 1 1 0.996879 1 0.9969 zgc:85777 zgc:85777 --- metabolic process acyl-CoA dehydrogenase activity /// electron carrier activity --- /// oxidoreductase activity /// oxidoreductase activity, acting on the CH-CH group of donors /// FAD binding

Dr.6419.1.A1 at -2.3918 -1.8745 -2.26676 -1.67101 0.871538 1 0.833647 1 0.8336 LOC796249 similar to A------Dr.6427.1.A1 at -1.3817 -1.96273 -2.26638 -1.77468 1 1 0.850713 1 0.8507 zgc:65893 zgc:65893 ------Dr.643.1.S1 at 2.075822 4.959292 6.348973 8.612933 1 0.019067 0.011935 0.01219 0.0119 rpl21 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.6431.1.S1 at 2.520869 3.405673 3.332167 2.915149 0.869219 0.430799 0.481566 0.647358 0.4308 socs3a suppressor --- intracellular signaling cascade protein binding --- Dr.6442.1.A1 at 1.889051 2.864547 2.533354 3.086562 1 0.263112 0.894192 0.046896 0.0469 zgc:92875 zgc:92875 ------Dr.645.1.S1 at -1.02108 1.639435 2.118668 2.515146 1 1 0.985798 0.264 0.264 rpl30 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.6457.1.S1 at -1.21873 -1.16827 -1.57253 -2.44194 1 1 1 0.519115 0.5191 wu:fj40g07 wu:fj40g07 ------Dr.6460.1.S1 at -1.57627 -2.30132 -2.39282 -1.75568 1 0.962 0.871 1 0.871 zgc:92606 zgc:92606 ------Dr.6473.1.A1 at -1.14008 -1.96997 -3.15412 -1.76159 1 1 0.071353 1 0.0714 wu:fj48a08 wu:fj48a08 ------Dr.6478.1.A1 at 2.850028 4.366762 3.649128 3.679531 0.119167 0.054633 0.009335 0.010943 0.0093 si:rp71-1p14.10 si:rp71-1p1 --- signal transduction --- intracellular Dr.6479.1.A1 at -1.26753 -1.7013 -2.843 -1.99036 1 1 0.096861 0.994659 0.0969 wu:fj52a05 wu:fj52a05 ------Dr.6493.1.A1 at 1.971108 1.888393 3.092095 3.831749 0.999955 1 0.546385 0.363 0.363 gro1 Groucho 1 --- regulation of transcription --- nucleus Dr.6496.2.A1 at 2.184124 2.665131 1.979783 1.302192 0.94396 0.09053 1 1 0.0905 im:6893790 im:6893790------Dr.6501.1.S1 at 1.288937 3.089441 2.756026 2.188164 1 0.359 0.587696 0.973527 0.359 sb:cb825 sb:cb825 --- cell redox homeostasis isomerase activity endoplasmic reticulum Dr.6506.1.A1 at -2.11908 -2.69964 -3.60782 -2.53928 0.9997 0.796 0.172 0.668186 0.172 zgc:63556 Zgc:63556 --- coenzyme A biosynthetic process pantothenate kinase activity /// ATP binding --- Dr.6517.1.S1_at -1.65474 -1.60516 -1.47883 -2.06937 1 1 1 0.972632 0.9726 adssl1 Adenylosuc--- purine nucleotide biosynthetic process nucleotide binding /// magnesium ion binding /// --- adenylosuccinate synthase activity /// GTP binding /// ligase activity /// metal ion binding Dr.6517.2.S1 at -1.45762 -1.97739 -1.31353 -2.45481 1 1 1 0.595 0.595 LOC796564 similar to T------Dr.6517.3.A1 at 1.463524 1.728221 1.677657 3.397015 1 1 1 0.131757 0.1318 ------Dr.6534.1.A1 at -2.0202 -1.97441 -2.38459 -2.22271 1 1 0.765922 0.768241 0.7659 wu:fe11a06 wu:fe11a06------Dr.6540.1.A1 at 1.087623 -2.27435 -2.90455 -2.28109 1 0.996552 0.772289 0.994582 0.7723 wu:fd43b11 wu:fd43b11------Dr.6563.1.A1 at 1.045644 1.387072 1.819884 2.193122 1 1 1 0.99934 0.9993 zgc:136279 zgc:136279--- metabolic process methyltransferase activity --- Dr.6568.1.A1 at -1.00855 -2.04962 -1.43697 1.827401 1 0.989 1 1 0.989 wu:fj41a03 wu:fj41a03 ------Dr.6569.1.A1 at -1.06005 1.369948 2.226998 -1.14302 1 1 0.647744 1 0.6477 wu:fe16d09 wu:fe16d09------Dr.6570.1.S2 at 2.563373 2.396349 1.129154 1.58323 0.689069 0.710384 1 1 0.6891 cited3 Cbp/p300-i--- regulation of transcription transcription regulator activity nucleus Dr.6571.1.S1_at -1.12636 1.255127 1.433686 2.32776 1 1 1 0.833 0.833 cndp2 CNDP dipe--- proteolysis metallopeptidase activity /// hydrolase activity /// protein --- dimerization activity Dr.6582.1.A1 at 1.60686 1.948903 1.927962 2.092955 1 1 1 0.994331 0.9943 casc3 cancer sus------Dr.6604.2.A1 a at -5.30858 -4.48185 -5.46717 -2.80551 0.221394 0.306428 0.204312 0.785 0.2043 zgc:77112 zgc:77112 ------Dr.6615.1.A1 at -2.77919 -1.93291 1.023103 -1.1386 0.196562 1 1 1 0.1966 zgc:152859 zgc:152859------Dr.6619.1.S1_at 1.644657 1.725033 2.657621 2.329588 1 1 0.32723 0.848446 0.3272 pgd phosphoglu--- pentose-phosphate shunt /// metabolic process /// oxidation catalytic activity /// phosphogluconate dehydrogenase --- reduction (decarboxylating) activity /// binding /// oxidoreductase activity /// NADP binding /// coenzyme binding Dr.6620.1.A1 at 2.059858 1.929652 1.889508 2.040626 0.998 1 1 1 0.998 LOC792682 similar to z------nucleic acid binding /// zinc ion binding intracellular Dr.6623.1.A1 at 1.471249 1.850811 1.653209 2.599846 1 1 1 0.444683 0.4447 wu:fi14a03 wu:fi14a03 --- inflammatory response /// complement activation endopeptidase inhibitor activity /// protein binding extracellular region Dr.6628.1.A1 at 2.850018 3.156945 2.017537 1.673139 0.632996 0.155203 0.999955 1 0.1552 zgc:163008 zgc:163008------protein binding --- Dr.6631.1.A1_at 1.865943 2.600885 1.786599 1.668778 1 0.35 1 1 0.35 kdelr2 KDEL (Lys --- protein retention in ER lumen /// transport /// protein receptor activity /// ER retention sequence binding endoplasmic reticulum /// endoplasmic transport /// vesicle-mediated transport reticulum membrane /// membrane /// integral to membrane Dr.664.1.S1_at 1.508332 2.850111 3.846302 5.482425 1 0.301852 0.044846 0.018 0.018 tuba8l4 tubulin, alp--- microtubule-based process /// microtubule-based movement nucleotide binding /// GTPase activity /// structural molecule microtubule /// protein complex /// protein polymerization activity /// GTP binding Dr.664.3.S1 at 1.313621 2.839995 3.479058 5.759641 1 0.231 0.097456 0.017744 0.0177 zgc:114188 zgc:114188--- translation structural constituent of ribosome intracellular /// ribosome Dr.6645.1.S1 at 1.444019 2.57366 2.32438 1.833691 1 0.366 0.934974 1 0.366 rer1 RER1 reten------integral to membrane Dr.6652.1.S2 at -1.61117 -2.12566 -1.49837 -1.93446 1 0.758701 1 1 0.7587 scarb1 scavenger --- cell adhesion receptor activity lysosome /// membrane Dr.6665.1.A1 at -1.19069 -1.13404 1.060333 3.456208 1 1 1 0.057469 0.0575 shcbp1 SHC SH2------Dr.6666.1.S1_at 1.651254 2.52684 2.326531 2.290902 1 0.340628 0.87033 0.968307 0.3406 med7 mediator co--- transcription /// transcription termination /// regulation of transcription coactivator activity nucleus transcription, DNA-dependent /// transcription antitermination /// positive regulation of transcription Dr.667.1.S1 at 1.048 1.738357 2.058834 2.469037 1 1 0.999955 0.438 0.438 rbx1 ring-box 1 --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.6673.1.A1 at 1.929453 3.215073 2.577373 2.074726 1 0.513566 0.895466 0.999955 0.5136 LOC559035 similar to s------Dr.6683.1.A1 at -2.59731 -2.54537 -2.52245 -2.13727 0.528285 0.632211 0.756 0.993617 0.5283 wu:fb40c06 wu:fb40c06------Dr.669.1.S1_at 2.528673 4.432817 3.519121 3.257447 0.739729 0.144 0.382 0.305503 0.144 chpt1 choline pho--- phospholipid biosynthetic process magnesium ion binding /// diacylglycerol Golgi membrane /// Golgi apparatus /// cholinephosphotransferase activity /// transferase activity /// membrane /// integral to membrane phosphotransferase activity, for other substituted phosphate groups /// manganese ion binding /// metal ion binding

Dr.6703.1.A1 at -1.63727 -1.67324 -1.4927 -2.14509 1 1 1 0.965 0.965 CH211-106H4.12 hypothetica------Dr.673.1.A1 at -1.23058 -1.45958 -1.91303 -2.1178 1 1 1 0.723712 0.7237 rtn1b reticulon 1b------endoplasmic reticulum Dr.6735.1.A1 at -1.69713 -3.03416 -4.81608 -3.65673 1 0.226309 0.052057 0.048262 0.0483 wu:fj37c02 wu:fj37c02 ------Dr.6747.1.S1_at 2.157028 3.288837 2.756988 3.24947 0.991636 0.055498 0.137165 0.081805 0.0555 got2b glutamic-ox--- amino acid metabolic process /// biosynthetic process catalytic activity /// aspartate transaminase activity /// --- transaminase activity /// transferase activity /// transferase activity, transferring nitrogenous groups /// pyridoxal phosphate binding Dr.6759.1.A1 at -4.65271 -1.43477 -1.8807 -1.73602 0.063771 1 1 1 0.0638 wu:fb81c07 wu:fb81c07------Dr.6769.1.A1_at 1.425749 2.603997 2.067995 -1.2531 1 0.771261 0.999955 1 0.7713 creb3l3 cAMP resp--- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription specific DNA binding /// protein dimerization activity

Dr.6774.1.A1 at 1.918397 6.682264 5.727171 1.852367 1 0.044692 0.038343 1 0.0383 wu:fj51c11 wu:fj51c11 ------Dr.6786.1.A1_at -1.28223 1.02838 1.439719 2.374525 1 1 1 0.783315 0.7833 si:dkeyp-35b8.5 si:dkeyp-35--- DNA replication /// DNA repair /// DNA recombination /// nucleotide binding /// DNA binding /// DNA ligase (ATP) --- response to DNA damage stimulus activity /// ATP binding /// ligase activity Dr.6789.1.A1 at 1.286725 3.043519 3.441945 2.606321 1 0.138 0.074754 0.385568 0.0748 wu:fj59h01 wu:fj59h01 ------Dr.6796.1.A1 at -1.28797 -2.33602 -3.69655 -2.57653 1 0.949741 0.135571 0.539733 0.1356 tmem59l transmemb------Dr.6801.1.S1_at -2.15593 -2.57253 -3.03315 -2.50609 0.979 0.554804 0.125847 0.338556 0.1258 atp2a2a ATPase, C--- heart looping /// transport /// cation transport /// calcium ion nucleotide binding /// catalytic activity /// calcium-transporting membrane /// integral to membrane transport /// regulation of heart contraction /// metabolic ATPase activity /// ATP binding /// ATPase activity, coupled process /// proton transport to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Dr.6804.1.A1 at 1.32271 2.558573 3.590048 4.456309 1 0.378461 0.081511 0.045115 0.0451 LOC565636 similar to g ------Dr.6806.1.S1 at 1.085734 1.963778 2.04717 1.525119 1 1 0.996511 1 0.9965 keap1a kelch-like E ------protein binding --- Dr.6807.1.S1 at 1.189891 2.110287 2.067475 2.824945 1 0.90448 0.978485 0.24675 0.2468 zgc:158370 zgc:158370--- transport nucleotide binding /// nucleic acid binding intracellular Dr.6814.1.S1 at 1.682994 3.166158 3.200564 4.23804 1 0.387 0.208725 0.067229 0.0672 fabp3 fatty acid b--- transport transporter activity /// binding /// lipid binding --- Dr.682.2.S1_at 1.624142 1.764213 1.983978 2.744487 1 1 1 0.523 0.523 ap2m1 adaptor-rela--- transport /// intracellular protein transport /// vesicle- protein binding /// lipid binding plasma membrane /// coated pit /// membrane mediated transport /// clathrin adaptor complex /// clathrin coat of coated pit Dr.6829.1.A1_at 3.317736 1.665515 1.593319 1.932189 0.154053 1 1 1 0.1541 mycl1a v-myc mye --- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// transcription nucleus /// nucleus transcription, DNA-dependent /// regulation of transcription factor activity /// transcription regulator activity

Dr.683.1.A1 at 1.189426 2.112794 1.980946 1.522655 1 0.99994 1 1 0.9999 wu:fa17f05 wu:fa17f05 ------Dr.6834.1.A1_at -1.23195 1.486187 1.435384 2.610255 1 1 1 0.684789 0.6848 cpox coproporph--- porphyrin biosynthetic process /// hemoglobin biosynthetic coproporphyrinogen oxidase activity --- process Dr.6837.1.S1 at 1.359891 2.223163 2.126874 1.639201 1 0.910503 0.998 1 0.9105 znf259 zinc finger ------protein binding /// zinc ion binding --- Dr.6848.1.A1 at -2.70767 -3.11827 -3.61888 -3.18442 0.300393 0.194679 0.065544 0.032951 0.033 wu:fd51a05 wu:fd51a05------Dr.6856.1.S1 at 2.556634 3.58476 3.88469 4.103973 0.381726 0.050122 0.052146 0.028592 0.0286 eif3b eukaryotic t------Dr.6864.1.A1 at 1.605573 1.792232 1.66208 2.243818 1 1 1 0.962 0.962 mrps18b mitochondr--- translation structural constituent of ribosome intracellular /// ribosome Dr.6880.1.A1 at 1.649959 2.034781 2.148495 2.222594 1 0.99994 0.779087 0.440241 0.4402 ccnk cyclin K ------Dr.6884.1.S1_at -2.04585 -1.31017 -1.99189 -2.52946 1 1 0.9997 0.421246 0.4212 zgc:55813 zgc:55813 --- carbohydrate metabolic process catalytic activity /// calcium ion binding /// calcium ion binding --- /// cation binding Dr.6887.1.A1 at 1.351806 1.500855 1.771293 2.236813 1 1 1 0.65358 0.6536 zgc:77306 zgc:77306 --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding membrane /// integral to membrane Dr.6898.1.A1 at 1.622031 2.018041 1.773756 2.092602 1 1 1 0.995 0.995 chchd2l coiled-coil------Dr.6906.1.A1 at -1.28934 -1.56171 -2.04152 -1.64117 1 1 0.988 1 0.988 wu:fc17e06 wu:fc17e06------Dr.6924.1.S1_at 2.644838 5.060633 5.350481 6.61674 0.660994 0.057822 0.078749 0.033738 0.0337 ahcy S-adenosyl --- one-carbon compound metabolic process /// metabolic catalytic activity /// adenosylhomocysteinase activity /// --- process binding /// hydrolase activity Dr.6925.1.A1 at 2.279466 2.256826 2.320532 1.711332 0.979287 0.996 0.996 1 0.9793 CH211-210H11.3 hypothetica------Dr.6927.1.A1 a at 1.664062 6.084137 8.290517 12.16004 1 0.053428 0.061197 0.009413 0.0094 ------Dr.6928.1.S1_at 2.434825 4.608419 4.88587 4.710198 0.574 0.035935 0.035126 0.035172 0.0351 cct6a chaperonin --- protein folding /// cellular protein metabolic process nucleotide binding /// protein binding /// ATP binding /// cytoplasm unfolded protein binding Dr.6928.2.S1 at -1.72399 -1.97008 -1.50922 -2.13899 1 0.99934 1 0.895466 0.8955 qdprb2 quinoid dih --- metabolic process catalytic activity /// binding --- Dr.6928.3.S1 at -1.7799 -2.1602 -1.44344 -2.30067 1 0.892 1 0.966764 0.892 zgc:171517 zgc:171517--- metabolic process catalytic activity /// binding --- Dr.6928.3.S1 x at -1.41891 -1.85117 -1.21943 -2.04979 1 1 1 0.9997 0.9997 zgc:171517 zgc:171517--- metabolic process catalytic activity /// binding --- Dr.6930.1.S1_at 1.243034 2.32036 1.809803 1.83171 1 0.9027 1 1 0.9027 samm50 sorting and --- nucleosome assembly DNA binding nucleosome /// nucleus /// outer membrane Dr.6944.1.A1 at 1.32768 1.923835 2.157721 1.66771 1 1 0.81946 1 0.8195 zgc:100860 zgc:100860------Dr.6949.1.A1 at 2.616878 4.279198 3.828036 2.906231 0.506723 0.00972 0.051077 0.028652 0.0097 rcl1 RNA termin------catalytic activity /// RNA-3'-phosphate cyclase activity --- Dr.6949.2.S1_at 2.003486 3.851553 3.269883 2.575392 0.987303 0.018578 0.093 0.065551 0.0186 rcl1 RNA termin--- translation structural constituent of ribosome /// catalytic activity /// RNA- intracellular /// ribosome 3'-phosphate cyclase activity Dr.6958.1.S1_at -1.89169 -1.68976 -2.83102 -1.83222 1 1 0.146783 1 0.1468 slc39a13 Solute carr--- transport /// ion transport /// zinc ion transport /// zinc ion zinc ion transmembrane transporter activity /// zinc ion membrane /// integral to membrane transport /// metal ion transport binding /// metal ion transmembrane transporter activity

Dr.6959.1.A1 s at 1.87402 2.368044 2.068504 2.007576 1 0.788991 0.999955 1 0.789 opa3 optic atroph------mitochondrion Dr.6966.1.A1 at 2.501114 3.184035 2.698771 2.726989 0.942804 0.655835 0.694599 0.723712 0.6558 sfrs2ip splicing fac------Dr.6999.1.A1 at 1.383951 -1.78095 -2.16698 -2.0245 1 1 0.995 1 0.995 ------Dr.7003.1.A1 at -1.7054 -2.07556 -1.33932 -2.76621 1 0.990497 1 0.46554 0.4655 bmp15 bone morph--- oocyte maturation /// oocyte maturation growth factor activity extracellular region Dr.7023.1.A1 at 1.968203 2.732284 3.014333 3.328536 0.999917 0.432757 0.369209 0.182924 0.1829 zgc:77665 zgc:77665 --- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.7026.1.A1_at 1.70435 2.614864 2.876684 2.918386 1 0.03595 0.045139 0.038888 0.0359 zgc:73143 zgc:73143 --- mRNA processing phosphoprotein phosphatase activity /// hydrolase activity nucleus /// cytoplasm

Dr.7026.2.S1_at 1.225396 2.185981 2.724024 3.029721 1 0.878656 0.164839 0.075242 0.0752 zgc:73143 zgc:73143 --- mRNA processing phosphoprotein phosphatase activity /// hydrolase activity nucleus /// cytoplasm

Dr.7030.1.A1 at 3.069637 3.122716 2.521659 3.077464 0.203747 0.252861 0.758 0.194102 0.1941 im:6907928 im:6907928------Dr.7036.1.S1 at 2.465733 3.792253 3.713163 3.701484 0.769517 0.161499 0.188273 0.144517 0.1445 g3bp1 GTPase ac--- transport nucleotide binding /// nucleic acid binding intracellular Dr.705.1.A1 at 1.267674 1.828964 2.079052 1.885756 1 1 0.980064 1 0.9801 rnps1 RNA bindin------nucleotide binding /// nucleic acid binding --- Dr.707.1.A1 at 1.503457 2.710037 2.354847 1.364485 1 0.925552 0.748447 1 0.7484 si:ch211-286m4.1 si:ch211-28------Dr.7076.1.A1 at 1.005034 -2.77308 -2.80316 -2.84922 1 0.760248 0.552572 0.609448 0.5526 wu:fj45h10 wu:fj45h10 ------Dr.708.1.A1_at 1.395422 2.460332 2.669901 2.855984 1 0.794 0.565295 0.435 0.435 hnrpa1 heterogene------nucleotide binding /// nucleic acid binding /// zinc ion binding intracellular /// ribonucleoprotein complex

Dr.7080.1.A1 at -2.31802 -2.08896 -2.63713 -1.61038 0.913 0.998 0.670481 1 0.6705 bco2b beta-carote------Dr.7080.1.A1 x at -2.15338 -1.93986 -2.01193 -1.53783 0.995813 1 0.999955 1 0.9958 bco2b beta-carote------Dr.709.1.S1 at -1.2111 1.771911 2.111687 2.47785 1 1 0.999955 0.975323 0.9753 arf2 ADP-ribosy--- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.7100.1.A1 at 1.568911 2.10528 2.062063 1.864983 1 0.972632 0.988 1 0.9726 ------Dr.7103.1.S1 at -1.49526 -3.4891 -1.50223 -1.19096 1 0.04533 1 1 0.0453 id3 inhibitor of --- regulation of transcription transcription regulator activity nucleus Dr.7107.1.A1 at 1.553526 2.850765 3.494026 3.294613 1 0.128945 0.024376 0.230144 0.0244 pno1 partner of N------RNA binding nucleus /// nucleolus Dr.7108.1.S1_at 2.483353 3.568924 3.127725 2.973038 0.587436 0.110776 0.132 0.224494 0.1108 hspd1 heat shock --- protein folding /// response to stress /// fin regeneration /// nucleotide binding /// protein binding /// ATP binding /// --- tissue regeneration /// cellular protein metabolic process unfolded protein binding

Dr.7110.1.S1 at -1.76223 -2.28141 -1.29899 -2.64845 1 0.904713 1 0.60853 0.6085 zgc:77614 zgc:77614 ------Dr.7116.1.S1 at 2.53111 2.747647 2.811015 2.018749 0.711231 0.70893 0.509404 0.999955 0.5094 mphosph10 M-phase ph------Dr.7118.1.A1 at -2.3984 -1.01596 1.022491 -1.37076 0.987 1 1 1 0.987 zgc:101644 zgc:101644------nucleic acid binding nucleus Dr.7123.1.A1 at 1.946108 1.526583 1.313037 2.312891 1 1 1 0.993617 0.9936 wu:fc26e09 wu:fc26e09------Dr.7124.1.S1_at 1.428376 2.317098 1.897119 2.235651 1 0.556448 1 0.898 0.5564 mthfd1 methylenet --- metabolic process /// folic acid and derivative biosynthetic catalytic activity /// formate-tetrahydrofolate ligase activity /// --- process binding /// ATP binding Dr.7126.1.S1_at 1.538198 2.180305 2.216117 1.652436 1 0.601275 0.458196 1 0.4582 copb1 coatomer p--- intracellular protein transport /// vesicle-mediated transport structural molecule activity /// binding /// protein binding membrane coat /// COPI vesicle coat /// notochord development Dr.7155.2.S1_at 1.288974 1.03664 -1.18158 3.161708 1 1 1 0.482219 0.4822 nusap1 nucleolar a--- cell cycle /// mitosis /// cell division DNA binding /// microtubule binding nucleus /// nucleolus /// cytoplasm /// microtubule /// spindle microtubule Dr.716.1.A1_at -2.00981 -4.3426 -4.10955 -3.86311 0.9997 0.06754 0.045925 0.059763 0.0459 LOC100150536 hypothetica--- cell cycle --- nucleus /// mitochondrion /// Golgi apparatus /// plasma membrane /// membrane

Dr.7163.1.A1 at -1.17735 -2.40962 -2.69691 -1.82621 1 0.9648 0.760442 1 0.7604 ttpa tocopherol --- transport transporter activity intracellular Dr.7164.1.A1_at 1.14319 1.945959 2.261506 2.38178 1 1 0.390845 0.391547 0.3908 zgc:92668 zgc:92668 --- proteolysis metallopeptidase activity /// zinc ion binding /// hydrolase --- activity Dr.7168.1.S1 at 2.020288 2.45619 1.732656 1.653052 0.997562 0.736 1 1 0.736 wu:fd56d05 wu:fd56d05------Dr.7184.1.A1_at 1.673131 2.367411 2.27747 1.25354 1 0.6568 0.973527 1 0.6568 zgc:86625 zgc:86625 --- nucleobase, nucleoside, nucleotide and nucleic acid ATP binding /// kinase activity /// phosphotransferase --- metabolic process activity, alcohol group as acceptor Dr.7186.1.A1 at 1.091363 2.170763 2.548498 2.708579 1 0.9 0.511733 0.136 0.136 wu:fe14c11 wu:fe14c11------Dr.7200.1.A1_at 1.615646 2.031369 2.048465 2.177685 1 1 0.999955 0.99934 0.9993 zgc:86607 zgc:86607 --- nuclear mRNA splicing, via spliceosome /// nuclear mRNA RNA binding nucleus /// spliceosome splicing, via spliceosome /// mRNA processing /// RNA splicing Dr.7203.1.S1_at 2.89557 3.639828 2.951208 2.275521 0.499249 0.138452 0.275221 0.931 0.1385 foxk2 forkhead bo--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding Dr.7204.2.A1 a at 1.082956 2.293711 1.705024 2.148439 1 0.957423 1 0.9997 0.9574 dnm2l dynamin2-l ------nucleotide binding /// GTPase activity /// GTP binding --- Dr.7215.1.S1 at 1.580178 2.151696 2.375691 2.347537 1 0.959 0.753488 0.693181 0.6932 mtch2 mitochondr--- transport binding membrane /// integral to membrane Dr.7226.1.S1 at 2.057646 2.644202 1.856849 1.626255 0.991443 0.429872 1 1 0.4299 wu:fj65h10 wu:fj65h10 ------Dr.7233.1.A1 at -1.35732 -1.78388 -2.18808 -2.20489 1 1 0.963 0.992263 0.963 wu:fj67h05 wu:fj67h05 ------Dr.7236.1.A1 at 1.558549 2.886277 1.650933 1.761457 1 0.225202 1 1 0.2252 wu:fc31g04 wu:fc31g04------Dr.7257.1.A1_at -5.52266 -2.29085 -2.34677 -3.26874 0.250226 0.989 0.991893 0.571623 0.2502 rasgef1ba RasGEF do--- small GTPase mediated signal transduction /// regulation of guanyl-nucleotide exchange factor activity intracellular small GTPase mediated signal transduction

Dr.7269.1.A1_at -1.63496 -2.03191 -2.01906 -2.1999 1 0.994816 0.999955 0.723212 0.7232 anxa4 annexin A4 --- calcium ion transport calcium channel activity /// calcium ion binding /// calcium- --- dependent phospholipid binding /// calcium channel inhibitor activity Dr.728.1.S1 x at -2.15977 -2.56904 -1.93531 -2.59216 0.99 0.759475 1 0.788152 0.7595 LOC100000152 /// LOC10similar to m --- transport --- nuclear pore Dr.7282.1.A1 at 4.744273 5.395261 2.880065 1.449276 0.060075 0.039326 0.277464 1 0.0393 si:ch211-157p10.1 si:ch211-15------Dr.7299.1.A1_at -1.8982 -2.18211 -1.51857 -2.36281 1 0.850395 1 0.636772 0.6368 LOC564818 similar to a--- RNA processing RNA binding /// double-stranded RNA binding /// adenosine intracellular deaminase activity Dr.730.1.A1 at 1.200243 2.066897 2.317588 2.521501 1 0.995 0.992952 0.564224 0.5642 thoc7 THO comp------nucleus /// cytoplasm Dr.7306.1.S1_at 1.439213 3.830859 3.329812 3.888382 1 0.08 0.239 0.068549 0.0685 scpep1 serine carb --- proteolysis carboxypeptidase activity /// serine-type carboxypeptidase --- activity Dr.7311.1.S1_at 6.600736 9.328154 8.938858 7.586378 0.015537 0.018683 0.009615 0.009615 0.0096 gnl3 guanine nu--- regulation of cell proliferation nucleotide binding /// protein binding /// GTP binding /// GTP intracellular /// nucleus /// nucleus /// nucleolus binding Dr.7318.1.S1_at 1.563531 2.410994 2.61268 3.046686 1 0.825536 0.128265 0.094307 0.0943 psmc2 proteasome --- protein catabolic process nucleotide binding /// ATP binding /// hydrolase activity /// nucleus /// cytoplasm /// cytosol /// protein nucleoside-triphosphatase activity complex Dr.732.1.S1 at 2.304772 3.246444 3.266766 2.922183 0.884 0.289704 0.233512 0.353 0.2335 rrp15 ribosomal R------Dr.7328.1.A1 at 2.038364 2.875303 2.948434 2.2976 0.985207 0.229559 0.343 0.839414 0.2296 wu:fi40b06 wu:fi40b06 ------Dr.733.1.A1 at 1.019358 1.055884 1.177763 5.11852 1 1 1 0.013089 0.0131 wu:fa20f04 wu:fa20f04 ------Dr.7332.1.A1 at 2.111769 1.714445 1.649913 2.057492 0.997562 1 1 0.568 0.568 CH211-214C7.4 hypothetica------Dr.7336.1.A1_at -1.8513 -1.82864 -2.07637 -1.89641 1 1 0.991278 1 0.9913 zgc:92082 zgc:92082 --- valine metabolic process /// metabolic process methylmalonate-semialdehyde dehydrogenase (acylating) --- activity /// oxidoreductase activity Dr.7337.1.S1_at 1.837572 3.012399 2.388812 2.765157 1 0.063696 0.814504 0.086313 0.0637 slc16a3 solute carri--- transport /// organic anion transport transporter activity /// secondary active monocarboxylate integral to membrane transmembrane transporter activity Dr.7340.1.A1 at 4.736447 3.874744 3.015727 1.944682 0.083234 0.11967 0.345 1 0.0832 slc16a9a solute carri--- transport transporter activity integral to membrane Dr.7341.1.A1_at 1.380288 2.56189 2.828758 4.164901 1 0.809205 0.459578 0.103514 0.1035 psmb2 proteasome --- ubiquitin-dependent protein catabolic process threonine-type endopeptidase activity /// endopeptidase nucleus /// cytoplasm /// cytosol /// proteasome inhibitor activity /// peptidase activity /// hydrolase activity core complex /// protein complex

Dr.7352.1.A1_at 2.785234 3.923507 4.651502 3.751022 0.799761 0.345669 0.226446 0.382 0.2264 ube2d2 ubiquitin-co--- post-translational protein modification /// regulation of ligase activity /// small conjugating protein ligase activity --- protein metabolic process Dr.7359.1.A1 at 1.246582 1.97501 2.018866 1.398398 1 1 0.999 1 0.999 tnip1 TNFAIP3 in------Dr.7368.1.A1 at 2.05514 2.276972 1.774366 -1.23031 1 0.85559 1 1 0.8556 nfkbiaa nuclear fac--- response to virus ------Dr.7375.1.A1 at -1.45071 -1.76892 -3.25614 -2.79379 1 1 0.109 0.190989 0.109 wu:fj19b07 wu:fj19b07 ------calcium ion binding --- Dr.7392.1.S1 at -1.98663 -2.39458 -2.33856 -1.98678 1 0.7 0.667265 1 0.6673 scrn3 secernin 3 --- proteolysis dipeptidase activity --- Dr.7404.1.A1 at 5.815764 3.348964 9.343315 13.6709 0.017744 0.102358 0.019717 0.007238 0.0072 wu:fj38c09 wu:fj38c09 ------Dr.742.1.S1 at 2.507604 -1.10833 -1.17955 -1.11586 0.368856 1 1 1 0.3689 tgfbi transformin------Dr.743.1.S1 at 1.368264 1.787013 2.016894 2.807985 1 1 0.999917 0.603461 0.6035 zgc:92775 zgc:92775 ------Dr.7434.1.A1 at 1.312733 1.615345 1.751212 2.321628 1 1 1 0.985207 0.9852 ndufb4 NADH deh--- ubiquinone biosynthetic process NADH dehydrogenase (ubiquinone) activity mitochondrion Dr.7444.1.S1 at 1.340609 1.496925 1.644603 2.516009 1 1 1 0.728 0.728 cox7c cytochrome ------cytochrome-c oxidase activity --- Dr.745.1.A1 at 1.253066 1.985055 2.116245 1.550749 1 1 0.98838 1 0.9884 zgc:56116 zgc:56116 --- zinc ion transport protein binding /// zinc ion binding /// metal ion binding --- Dr.7462.1.A1 at -2.32468 -1.89846 -2.56797 -3.73632 0.986747 1 0.850395 0.369171 0.3692 mbp myelin basi------structural constituent of myelin sheath --- Dr.7464.1.S1_at 2.455291 2.941557 2.911165 3.37126 0.621 0.122221 0.081187 0.055579 0.0556 cox5aa cytochrome --- spinal cord motor neuron differentiation /// embryonic organ cytochrome-c oxidase activity /// cytochrome-c oxidase --- development activity Dr.7466.1.S1_at -2.7498 -1.18483 -1.90566 -2.0641 0.549409 1 1 1 0.5494 ak3l1 adenylate k--- nucleobase, nucleoside, nucleotide and nucleic acid adenylate kinase activity /// ATP binding /// kinase activity /// --- metabolic process transferase activity /// phosphotransferase activity, phosphate group as acceptor /// nucleotide kinase activity /// nucleobase, nucleoside, nucleotide kinase activity

Dr.7467.1.S1_at 5.19728 10.37637 7.153151 5.695513 0.056294 0.010818 0.010318 0.024361 0.0103 serinc5 serine inco--- lipid metabolic process /// phospholipid biosynthetic process electron carrier activity endoplasmic reticulum /// endoplasmic reticulum membrane /// membrane /// integral to membrane Dr.7488.1.S1 at 1.680254 2.422261 2.543507 2.371619 1 0.503322 0.332847 0.558647 0.3328 tmem33 transmemb------integral to membrane Dr.749.1.S1_at 1.582727 3.04856 3.334607 2.988254 1 0.186 0.131898 0.200695 0.1319 tcp1 t-complex p--- protein folding /// cellular protein metabolic process nucleotide binding /// protein binding /// ATP binding /// cytoplasm unfolded protein binding Dr.7496.1.A1 at 1.712656 2.463231 2.307537 1.876373 1 0.783682 0.938 1 0.7837 syncripl synaptotag------nucleotide binding /// nucleic acid binding --- Dr.7516.1.A1 at -4.25768 -2.12747 -3.60359 -2.09301 0.212648 0.984 0.194276 0.987681 0.1943 slc38a4 solute carri------membrane /// integral to membrane Dr.752.1.A1 at 1.416421 1.870347 1.905046 2.284476 1 1 1 0.555766 0.5558 LOC562425 hypothetica------Dr.7525.1.A1_at 3.633124 5.272605 5.365378 4.512343 0.160671 0.055818 0.063 0.089662 0.0558 zgc:110154 zgc:110154--- translation /// translational initiation /// transport RNA binding /// translation initiation factor activity /// cytoplasm transporter activity /// binding Dr.7568.1.A1_at 2.279713 2.593587 2.627433 3.035344 0.962505 0.907 0.908747 0.616564 0.6166 si:ch211-132p20.4 si:ch211-13--- transport /// ion transport /// sodium ion transport /// amino sodium channel activity /// symporter activity /// sodium plasma membrane /// membrane /// integral to acid transport channel inhibitor activity /// sodium ion binding membrane Dr.7573.1.A1 at 2.07445 1.838205 1.84919 2.379652 0.99934 1 1 0.782262 0.7823 wu:fc76b04 wu:fc76b04------calcium ion binding --- Dr.758.1.A1_at -1.76674 -2.12707 -2.9226 -2.5619 1 0.947 0.208334 0.255125 0.2083 atp1b3a ATPase, N--- transport /// ion transport /// potassium ion transport /// sodium:potassium-exchanging ATPase activity membrane /// integral to membrane sodium ion transport Dr.7590.1.A1 at 3.712876 4.511819 4.124239 4.061111 0.09142 0.050812 0.046673 0.043455 0.0435 wu:fj68b05 wu:fj68b05 ------Dr.7603.1.A1 at -3.50317 -2.43123 -3.0585 -2.57953 0.025525 0.485671 0.053952 0.068684 0.0255 itm2c integral me------Dr.7609.1.A1 at -1.40641 -1.74746 -2.5812 -2.22941 1 1 0.929804 0.991811 0.9298 wu:fj65c07 wu:fj65c07 ------Dr.7616.1.A1_s_at 1.655266 2.152255 1.887976 1.564429 1 0.731 1 1 0.731 tkt transketola --- metabolic process catalytic activity /// transketolase activity /// transferase --- activity Dr.7626.2.S1_at -1.37614 -1.47738 -1.60315 -2.26814 1 1 1 0.990731 0.9907 pfkfb3 6-phosphof --- fructose metabolic process /// fructose 2,6-bisphosphate catalytic activity /// 6-phosphofructo-2-kinase activity /// ATP --- metabolic process /// metabolic process binding /// kinase activity Dr.7636.1.A1 at 2.182582 1.674913 1.256796 1.378563 0.784477 1 1 1 0.7845 ------Dr.7639.1.A1 at -4.70858 -4.18735 -4.3454 -3.14533 0.048055 0.046061 0.064784 0.5222 0.0461 LOC567234 novel prote------Dr.7641.1.A1_at 1.163749 1.709853 1.749815 2.109739 1 1 1 0.875 0.875 LOC100000432 /// si:ch21similar to R--- mRNA capping /// mRNA capping /// mRNA processing RNA binding /// RNA binding /// mRNA (guanine-N7-)- nucleus /// nucleus methyltransferase activity /// mRNA (guanine-N7-)- methyltransferase activity /// methyltransferase activity /// transferase activity Dr.7644.1.S1_at 2.300802 3.732359 3.981188 4.302131 0.979693 0.164639 0.095535 0.111345 0.0955 cct2 chaperonin --- protein folding /// protein amino acid phosphorylation /// nucleotide binding /// protein kinase activity /// protein cytoplasm cellular protein metabolic process binding /// ATP binding /// unfolded protein binding Dr.7644.2.A1_at 1.688634 3.391911 3.978111 3.84323 1 0.186707 0.080828 0.089071 0.0808 cct2 Chaperonin --- protein folding /// protein amino acid phosphorylation /// nucleotide binding /// protein kinase activity /// protein cytoplasm cellular protein metabolic process binding /// ATP binding /// unfolded protein binding Dr.7659.1.A1 at 1.906443 2.767471 2.424956 2.507135 1 0.406765 0.884234 0.348 0.348 zgc:77282 zgc:77282 ------nucleotide binding /// nucleic acid binding --- Dr.7666.2.A1 at -1.8002 -1.98177 -1.77275 -2.29412 1 1 1 0.954 0.954 ------Dr.7674.1.S1_at 1.044513 1.296596 1.320793 2.139327 1 1 1 0.979287 0.9793 prps1b phosphorib--- nucleoside metabolic process /// ribonucleoside magnesium ion binding /// ribose phosphate --- monophosphate biosynthetic process /// nucleotide diphosphokinase activity /// kinase activity /// metal ion biosynthetic process /// cellular biosynthetic process binding Dr.7676.1.A1 at -1.40497 1.339815 1.967737 3.294834 1 1 1 0.173218 0.1732 zgc:77759 zgc:77759 --- visual perception --- membrane /// integral to membrane Dr.768.1.A1 at 1.485884 2.253331 2.370387 2.711874 1 0.647358 0.590882 0.12579 0.1258 im:7158249 im:7158249------Dr.7683.1.A1 at -1.38185 -2.18519 -3.33379 -2.98653 1 0.729624 0.078537 0.292695 0.0785 wu:fi15a11 wu:fi15a11 ------Dr.7685.1.S1 at 1.291191 2.22311 2.113583 1.751645 1 0.964549 0.999955 1 0.9645 zgc:55819 zgc:55819 ------protein binding --- Dr.7688.1.A1_at -2.20798 -1.77493 -1.6362 -1.3231 0.438249 1 1 1 0.4382 zgc:152876 zgc:152876--- protein metabolic process /// oxidation reduction iron ion binding /// procollagen-lysine 5-dioxygenase activity endoplasmic reticulum /// oxidoreductase activity /// oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Dr.7691.1.A1_at -1.53886 -1.93019 -2.84362 -1.7455 1 1 0.452937 1 0.4529 zgc:101761 zgc:101761--- protein amino acid ADP-ribosylation /// signal transduction nucleotide binding /// signal transducer activity /// GTP --- /// G-protein coupled receptor protein signaling pathway binding /// guanyl nucleotide binding

Dr.770.1.A1 at 2.002524 2.613609 1.970696 2.047214 0.99994 0.777 1 0.999955 0.777 ------Dr.7713.1.S1_at 4.767837 8.329999 8.980032 8.589702 0.043888 0.013905 0.010488 0.011485 0.0105 timm23 translocase --- transport /// intracellular protein transport /// intracellular protein transporter activity /// protein transporter activity /// P- mitochondrion /// mitochondrial outer protein transport /// multicellular organismal development /// P-bond-hydrolysis-driven protein transmembrane transporter membrane /// mitochondrial inner membrane protein transport /// protein import into mitochondrial inner activity /// P-P-bond-hydrolysis-driven protein /// mitochondrial inner membrane presequence membrane /// intracellular protein transport across a transmembrane transporter activity translocase complex /// mitochondrial inner membrane membrane presequence translocase complex /// membrane /// integral to membrane /// integral to membrane /// outer membrane /// mitochondrial intermembrane space protein transporter complex

Dr.7725.1.S1 at 2.192237 3.087873 2.878994 2.510091 0.82222 0.074436 0.090361 0.201459 0.0744 wdr12 WD repeat ------Dr.7731.1.A1 at 1.876377 -1.33818 -1.87981 -2.27271 1 1 1 0.750884 0.7509 zgc:158869 zgc:158869------nucleotide binding nucleus Dr.7734.1.S1_a_at -1.81928 -2.02344 -1.71266 -2.09365 1 0.99321 1 0.983688 0.9837 mcm3l MCM3 min --- DNA replication initiation nucleotide binding /// DNA binding /// ATP binding /// nucleus nucleoside-triphosphatase activity Dr.7737.1.A1 at -1.45411 -1.56925 -1.96926 -2.08067 1 1 1 0.9997 0.9997 wu:fi27h03 wu:fi27h03 ------Dr.7742.1.S1 at 2.404401 1.789436 1.625909 -1.07594 0.363554 1 1 1 0.3636 zgc:77633 zgc:77633 --- small GTPase mediated signal transduction nucleotide binding /// GTP binding intracellular Dr.776.1.S1_at 1.779396 2.844138 2.625554 2.344156 1 0.474423 0.167338 0.774 0.1673 si:dkey-235d18.4 si:dkey-235--- translation /// translational elongation translation elongation factor activity eukaryotic translation elongation factor 1 complex Dr.777.1.A1_at 1.185865 1.796883 2.014372 2.259849 1 1 1 0.894553 0.8946 psmc5 proteasome --- small GTPase mediated signal transduction /// protein nucleotide binding /// protein binding /// ATP binding /// GTP proteasome complex /// nucleus /// nucleus /// catabolic process /// proteasomal ubiquitin-dependent binding /// transcription factor binding /// hydrolase activity /// cytoplasm /// cytoplasm protein catabolic process ATPase activity /// nucleoside-triphosphatase activity /// thyrotropin-releasing hormone receptor binding

Dr.7788.1.A1 at -2.14614 -2.7524 -2.65967 -2.96156 0.9997 0.67534 0.752318 0.552465 0.5525 wu:fj21f03 wu:fj21f03 ------Dr.7801.1.A1 at -1.05678 -2.13991 -2.61333 -3.00783 1 0.998961 0.827638 0.597473 0.5975 zgc:110586 zgc:110586------membrane /// integral to membrane Dr.7806.1.A1 at -1.70828 -2.27349 -1.5375 -2.75017 1 0.82222 1 0.316393 0.3164 ------Dr.781.1.S1_at 2.596679 4.92626 5.948887 6.650605 0.396 0.031565 0.011641 0.010492 0.0105 mibp2 muscle-spe--- integrin-mediated signaling pathway ATP binding /// phosphotransferase activity, alcohol group --- as acceptor Dr.7818.1.A1 at -2.39062 -1.74372 -2.60745 -2.74806 0.287363 1 0.0946 0.180204 0.0946 wu:fj38f11 wu:fj38f11 ------Dr.7819.1.A1 at -3.99813 -2.77369 -2.39989 -3.77235 0.418385 0.906 0.970026 0.481566 0.4184 wu:fj39e03 wu:fj39e03 ------Dr.782.1.S1 at 1.687463 3.109854 2.571191 2.795126 1 0.020352 0.379152 0.030622 0.0204 zgc:85960 zgc:85960 ------nucleotide binding /// nucleic acid binding --- Dr.7820.1.A1 at 1.602551 2.2584 2.188571 3.02952 1 0.601658 0.962 0.045915 0.0459 wu:fc58c12 wu:fc58c12------Dr.784.1.S1_at 1.255702 1.738157 2.95258 4.592253 1 1 0.32444 0.11186 0.1119 mcm3 MCM3 min --- DNA replication initiation /// retina development in camera- nucleotide binding /// DNA binding /// ATP binding /// nucleus type eye nucleoside-triphosphatase activity Dr.7840.1.S1_at -1.13205 -1.3664 -1.96868 -2.25848 1 1 1 0.101424 0.1014 atp1a1b ATPase, N--- transport /// ion transport /// cation transport /// potassium nucleotide binding /// catalytic activity /// potassium channel membrane /// integral to membrane /// integral ion transport /// metabolic process /// monovalent inorganic activity /// ATP binding /// monovalent inorganic cation to membrane cation transport /// sperm motility /// regulation of cellular pH transmembrane transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances /// potassium channel inhibitor activity /// potassium ion binding

Dr.7842.1.A1 at 4.070107 -1.01841 -1.11321 -1.01488 0.600871 1 1 1 0.6009 wu:fj15c09 wu:fj15c09 ------Dr.7852.1.S1_at 2.035489 2.523761 2.425127 1.859545 0.999955 0.61425 0.480499 1 0.4805 utp11l UTP11-like--- rRNA processing nucleic acid binding ribonucleoprotein complex /// small-subunit processome Dr.7859.1.A1 at -1.1227 -1.82214 -2.4517 -2.27618 1 1 0.309624 0.572 0.3096 LOC567576 similar to s------Dr.786.1.S1_at 1.108138 1.941991 2.181328 3.088051 1 1 0.988 0.324498 0.3245 psma2 proteasome --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase cytosol /// proteasome core complex /// protein activity /// endopeptidase inhibitor activity /// peptidase complex activity /// hydrolase activity Dr.7861.1.A1_at -1.05043 2.52023 2.406771 2.02085 1 0.913 0.954 1 0.913 zgc:103631 zgc:103631--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus /// nucleus transcription, DNA-dependent /// zinc ion transport /// hormone receptor activity /// receptor activity /// ligand- transcription antitermination dependent nuclear receptor activity /// steroid binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding Dr.7881.1.A1_at -1.73465 -2.34575 -2.74776 -3.2435 1 0.532226 0.165446 0.044 0.044 si:xx-35d8.1 si:xx-35d8. --- transport /// phagocytosis /// apoptosis /// metabolic process oxidoreductase activity cytoplasm

Dr.7883.1.A1 at 2.550982 -1.2272 -1.58958 -1.52316 0.88364 1 1 1 0.8836 zgc:112198 zgc:112198--- carboxylic acid metabolic process carboxy-lyase activity /// pyridoxal phosphate binding --- Dr.7887.1.A1 at 1.677579 2.59993 1.698037 1.778907 1 0.455826 1 1 0.4558 zgc:66415 zgc:66415 ------Dr.7888.1.S1 at 3.479265 4.635217 4.861292 3.601339 0.038558 0.05591 0.057629 0.017245 0.0172 rrs1 RRS1 ribos--- ribosome biogenesis --- nucleus Dr.7895.1.A1 at 2.645265 3.849103 3.311199 2.661615 0.770611 0.239726 0.381 0.813 0.2397 ------Dr.79.1.A1 at -1.23591 -4.22444 -4.0636 -3.44332 1 0.028033 0.018653 0.186909 0.0187 sb:cb382 sb:cb382 ------Dr.7906.1.S1_at 1.593446 1.631428 1.788719 3.505441 1 1 1 0.325359 0.3254 cox6a1 cytochrome ------cytochrome-c oxidase activity /// electron carrier activity mitochondrion /// mitochondrial envelope /// mitochondrial inner membrane /// membrane

Dr.7912.1.A1 at 2.182333 1.513749 1.503967 1.542047 0.999325 1 1 1 0.9993 si:ch211-147a11.3 si:ch211-14------Dr.7926.1.A1 at 2.98099 3.906515 3.98263 2.822262 0.083326 0.045893 0.032497 0.377369 0.0325 cirh1a cirrhosis, a------Dr.7939.1.A1_at 1.687363 2.670347 2.99049 2.209478 1 0.934488 0.268559 0.997562 0.2686 zgc:154041 zgc:154041--- translational elongation nucleotide binding /// translation elongation factor activity /// intracellular GTPase activity /// GTP binding Dr.7946.2.A1 a at -1.75052 -3.34929 -3.15775 -2.3717 1 0.053428 0.074788 0.866 0.0534 zgc:64130 zgc:64130 ------Dr.7949.1.S1_at -2.27276 -2.68366 -2.01274 -2.87531 0.799761 0.313 1 0.438 0.313 dlg1 discs, large --- endothelial cell proliferation /// actin filament organization /// protein binding /// protein binding /// protein kinase binding /// membrane /// basolateral plasma membrane synaptic transmission /// cell-cell adhesion /// cortical actin phosphatase binding cytoskeleton organization and biogenesis /// negative regulation of mitotic cell cycle /// synapse organization and biogenesis Dr.7951.1.S1_at 4.787157 5.987078 3.228281 2.204564 0.030624 0.007758 0.036613 0.628 0.0078 chn1 chimerin (c--- zinc ion transport /// signal transduction /// intracellular phorbol ester receptor activity /// protein binding /// zinc ion intracellular /// soluble fraction /// insoluble signaling cascade /// positive regulation of GTPase activity binding /// Rac GTPase activator activity /// Rac GTPase fraction activator activity /// metal ion binding Dr.7956.1.S2 at -2.98063 -5.9681 -4.33803 -5.40071 0.026368 0.007504 0.009371 0.054508 0.0075 zgc:171859 zgc:171859------structural molecule activity viral capsid Dr.796.1.S1 at -1.78921 -2.26118 -1.47741 -2.98447 1 0.733434 1 0.633509 0.6335 sb:cb492 sb:cb492 ------Dr.796.1.S1 x at -1.70569 -1.92897 -1.34148 -2.85219 1 1 1 0.610446 0.6104 sb:cb492 sb:cb492 ------Dr.7971.1.A1_at 1.462582 2.010105 2.107139 2.174433 1 1 0.926245 0.484853 0.4849 ipo9 importin 9 --- protein import into nucleus, docking /// intracellular protein binding /// protein transporter activity nucleus /// nuclear pore /// cytoplasm transport Dr.7972.1.S1 at 2.231843 3.001601 3.103906 3.236224 0.985798 0.502661 0.220095 0.474 0.2201 gtpbp4 GTP bindin--- small GTPase mediated signal transduction GTP binding --- Dr.7993.1.A1_at 2.407162 2.54425 2.146475 2.499629 0.857 0.602617 0.99994 0.667 0.6026 zgc:153999 zgc:153999--- ubiquitin-dependent protein catabolic process ubiquitin thiolesterase activity /// peptidase activity /// --- cysteine-type peptidase activity /// hydrolase activity Dr.8.1.S1 at 1.352583 2.663145 3.164323 3.158627 1 0.96723 0.885807 0.856805 0.8568 zgc:77429 zgc:77429 --- translational initiation translation initiation factor activity --- Dr.8.2.S1 at 1.267333 2.097529 2.389306 3.019212 1 0.835313 0.061483 0.023526 0.0235 rpl5b ribosomal p--- translation structural constituent of ribosome /// 5S rRNA binding intracellular /// ribosome Dr.800.1.S1_at 2.110531 3.435413 3.366948 3.230032 0.991876 0.16426 0.167193 0.09638 0.0964 smn1 survival mo--- spliceosome assembly /// mRNA processing /// nucleic acid binding /// RNA binding nucleus /// spliceosome /// cytoplasm axonogenesis /// RNA splicing /// axon extension involved in development Dr.8001.6.S1 a at 1.378291 2.992684 3.610708 5.047937 1 0.86555 0.631216 0.324899 0.3249 rps26 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.8004.1.A1_at 1.544667 2.679642 3.117541 2.391531 1 0.34353 0.14508 0.605686 0.1451 farsa phenylalany--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity /// ATP binding /// ligase activity Dr.8005.1.S1_at 1.186811 1.763113 1.590675 2.292116 1 1 1 0.827204 0.8272 ube2l3 ubiquitin-co--- post-translational protein modification /// regulation of ligase activity /// small conjugating protein ligase activity --- protein metabolic process Dr.8011.1.A1 at 3.763172 4.956911 4.835851 4.708766 0.038788 0.027972 0.017729 0.06273 0.0177 ------Dr.8025.1.S1 at -1.78555 -2.3278 -1.54781 -2.391 1 0.883 1 0.893 0.883 zgc:56324 zgc:56324 ------Dr.8025.2.A1 at -1.73833 -2.35682 -2.16176 -2.09659 1 0.542 0.941815 0.973288 0.542 wu:fa11d03 wu:fa11d03------Dr.8039.1.S2_at 1.604523 1.510156 -1.6486 -2.28606 1 1 1 0.948807 0.9488 kdrl kinase inse--- angiogenesis /// angiogenesis /// angiogenesis /// blood nucleotide binding /// protein kinase activity /// protein signal recognition particle, endoplasmic vessel development /// protein amino acid phosphorylation /// tyrosine kinase activity /// transmembrane receptor protein reticulum targeting /// membrane /// integral to transmembrane receptor protein tyrosine kinase signaling tyrosine kinase activity /// transmembrane receptor protein membrane /// integral to membrane pathway /// multicellular organismal development /// negative tyrosine kinase activity /// receptor activity /// vascular regulation of signal transduction /// cell differentiation /// endothelial growth factor receptor activity /// ATP binding /// thyroid gland development /// embryonic heart tube kinase activity /// transferase activity development

Dr.804.1.S1_at 1.386168 2.516734 2.636154 4.136106 1 0.402696 0.498045 0.029698 0.0297 sae1 SUMO1 ac--- protein modification process /// metabolic process catalytic activity /// binding /// small protein activating enzyme nucleus activity /// ligase activity Dr.8056.1.S1_at -1.26412 -2.62499 -2.18752 -2.43578 1 0.731676 0.9997 0.884912 0.7317 dkk1 dickkopf 1 --- multicellular organismal development /// ectoderm protein binding extracellular region /// extracellular region /// development /// negative regulation of Wnt receptor cytoplasm signaling pathway /// negative regulation of Wnt receptor signaling pathway /// regulation of cell migration /// forebrain development /// notochord development /// cell migration involved in gastrulation Dr.8063.1.S1 at 1.422849 2.313035 2.318495 1.747625 1 0.950312 0.984689 1 0.9503 mpp7 membrane ------protein binding tight junction /// membrane /// cell junction Dr.8066.1.S1_at 2.064112 1.907001 1.867172 2.10051 0.987228 0.999955 1 0.997562 0.9872 fzd8c frizzled hom--- signal transduction /// cell surface receptor linked signal signal transducer activity /// receptor activity /// non-G- membrane /// integral to membrane transduction /// G-protein coupled receptor protein signaling protein coupled 7TM receptor activity /// G-protein coupled pathway /// multicellular organismal development /// Wnt receptor activity receptor signaling pathway /// Wnt receptor signaling pathway Dr.8069.1.S1_at -1.83167 -2.09027 -1.96671 -2.85649 1 0.997 1 0.075345 0.0753 cryaba crystallin, a------structural constituent of eye lens /// unfolded protein binding plasma membrane

Dr.808.1.S1 at -1.14087 1.495679 1.771072 3.716283 1 1 1 0.038515 0.0385 h2afvl H2A histon--- nucleosome assembly DNA binding nucleosome /// nucleus /// chromosome Dr.8091.1.S1_at 1.891885 2.374111 2.607218 2.861232 1 0.284202 0.099686 0.077716 0.0777 gli2a GLI-Kruppe--- somitogenesis /// nervous system development /// muscle nucleic acid binding /// iron ion binding /// zinc ion binding /// intracellular development /// blood circulation /// biosynthetic process /// oxidoreductase activity dorsal/ventral pattern formation /// dorsal/ventral pattern formation /// floor plate formation /// floor plate formation /// somatic motor neuron differentiation /// central nervous system neuron differentiation /// central nervous system neuron differentiation /// adenohypophysis development /// endocrine pancreas development /// glomerulus development /// post-embryonic foregut morphogenesis /// regulation of neurogenesis /// regulation of neurogenesis /// striated muscle cell development

Dr.8095.1.A1 at -1.52802 -1.68472 -1.16602 -2.13478 1 1 1 0.950415 0.9504 sema3h semaphorin --- multicellular organismal development receptor activity membrane Dr.8097.1.S1_at -2.18083 -2.96529 -4.90286 -4.2178 0.99934 0.587189 0.139415 0.197582 0.1394 opn1sw2 opsin 1 (co--- signal transduction /// G-protein coupled receptor protein rhodopsin-like receptor activity /// signal transducer activity photoreceptor outer segment /// membrane /// signaling pathway /// visual perception /// phototransduction /// receptor activity /// G-protein coupled receptor activity /// integral to membrane /// integral to membrane /// protein-chromophore linkage /// response to stimulus photoreceptor activity /// blue light photoreceptor activity

Dr.8115.1.S1_at -1.97892 -1.8383 -2.23005 -2.34956 0.999955 1 0.890256 0.774 0.774 cdh4 cadherin 4, --- calcium ion transport /// cell adhesion /// homophilic cell calcium channel activity /// calcium ion binding /// protein membrane /// integral to membrane adhesion /// cranial nerve development /// regulation of eye binding /// calcium channel inhibitor activity photoreceptor cell development /// camera-type eye morphogenesis /// lateral line system development /// retina morphogenesis in camera-type eye

Dr.8125.1.S1_at -2.34672 -3.05199 -3.01567 -2.66697 0.99934 0.973 0.981 0.996674 0.973 thrb thyroid horm--- transcription /// transcription termination /// regulation of DNA binding /// transcription factor activity /// steroid nucleus transcription, DNA-dependent /// regulation of transcription, hormone receptor activity /// receptor activity /// ligand- DNA-dependent /// zinc ion transport /// transcription dependent nuclear receptor activity /// thyroid hormone antitermination receptor activity /// thyroid hormone receptor activity /// zinc ion binding /// transcription activator activity /// sequence- specific DNA binding /// metal ion binding Dr.8134.1.S1_at 1.565249 1.964493 1.605541 2.149618 1 1 1 0.975323 0.9753 psme2 proteasome ------proteasome activator activity cytosol /// proteasome activator complex /// protein complex Dr.8138.1.S1 at 1.133893 5.289078 10.65918 21.16921 1 0.08673 0.015764 0.006 0.006 kal1b Kallmann s------protease inhibitor activity extracellular region Dr.8139.1.S1_at -2.07235 -2.42167 -1.94171 -2.91432 1 0.200162 1 0.231734 0.2002 prox1 prospero-re--- lymphangiogenesis /// multicellular organismal development DNA binding /// transcription regulator activity nucleus /// nucleus /// forebrain neuron development /// myofibril assembly /// negative regulation of transcription factor activity /// regulation of transcription

Dr.8142.1.S1_at 1.13267 -1.67222 -1.41237 -2.10525 1 1 1 0.982 0.982 aanat2 arylalkylam--- circadian rhythm /// circadian rhythm /// metabolic process aralkylamine N-acetyltransferase activity /// protein binding /// --- /// response to light stimulus /// response to light stimulus /// N-acetyltransferase activity /// zinc ion binding /// photoperiodism acyltransferase activity /// acetyltransferase activity /// transferase activity /// metal ion binding Dr.8143.1.S1 at -1.64492 -2.25625 -1.47639 -2.11891 1 0.959 1 0.998 0.959 fabp2 fatty acid b--- transport transporter activity /// binding /// lipid binding --- Dr.8144.1.S1_at -1.6278 -2.09715 -1.63736 -2.51969 1 0.996 1 0.667445 0.6674 dtk developme--- protein amino acid phosphorylation nucleotide binding /// protein kinase activity /// protein --- tyrosine kinase activity /// receptor activity /// ATP binding /// kinase activity /// transferase activity Dr.8148.1.S1_at 5.533584 5.423472 4.665833 5.20259 0.168 0.155894 0.203106 0.152506 0.1525 ctnna catenin (ca --- cell adhesion structural molecule activity /// cadherin binding /// cadherin microvillus /// cell-cell adherens junction /// cell binding cortex /// actin cytoskeleton /// catenin complex /// desmosome Dr.815.2.S1_at 2.695821 3.648476 3.810426 3.878123 0.594 0.129698 0.033872 0.04355 0.0339 kars lysyl-tRNA --- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// nucleic acid binding /// aminoacyl- cytoplasm lysyl-tRNA aminoacylation tRNA ligase activity /// lysine-tRNA ligase activity /// ATP binding /// ligase activity Dr.8150.2.S1_a_at 2.066429 1.786246 1.477548 1.214768 0.972 1 1 1 0.972 stat3 signal trans--- establishment of planar polarity /// epithelial to mesenchymal transcription factor activity /// signal transducer activity /// nucleus transition /// regulation of transcription, DNA-dependent /// calcium ion binding /// protein binding signal transduction /// motor axon guidance /// establishment of cell polarity /// cell migration involved in gastrulation /// regulation of transcription

Dr.8152.1.S1_at 1.261027 -3.74291 -4.34896 -3.15357 1 0.240612 0.030912 0.273539 0.0309 slc40a1 solute carri--- transport /// ion transport /// iron ion transport /// iron ion iron ion transmembrane transporter activity /// iron ion membrane /// integral to membrane /// integral transport /// cellular iron ion homeostasis /// embryonic transmembrane transporter activity /// iron ion to membrane hemopoiesis /// hemoglobin biosynthetic process /// nucleate transmembrane transporter activity /// iron ion binding erythrocyte maturation Dr.8153.3.A1_at -1.73591 -2.1386 -1.57527 -2.13438 1 0.981819 1 0.961976 0.962 phex phosphate --- proteolysis /// zinc ion transport endopeptidase inhibitor activity /// metalloendopeptidase membrane inhibitor activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity

Dr.8154.1.S1_at -1.43277 -1.8407 -1.76637 -2.22449 1 1 1 0.996712 0.9967 bmpr1a /// zgc:136731 bone morph--- protein amino acid phosphorylation /// transmembrane nucleotide binding /// protein kinase activity /// protein membrane receptor protein serine/threonine kinase signaling pathway serine/threonine kinase activity /// transmembrane receptor protein serine/threonine kinase activity /// receptor signaling protein serine/threonine kinase activity /// receptor activity /// transforming growth factor beta receptor activity /// ATP binding /// kinase activity /// transferase activity

Dr.8170.1.A1_at -1.01136 -1.24047 -1.69582 -2.07234 1 1 1 0.986338 0.9863 ctsf cathepsin F--- proteolysis cysteine-type endopeptidase activity /// endopeptidase --- inhibitor activity /// cysteine protease inhibitor activity /// cysteine-type peptidase activity Dr.8174.1.S1_at -1.30556 -1.89114 -2.05213 -3.14132 1 1 0.999955 0.933 0.933 ptpra protein tyro--- protein amino acid phosphorylation /// protein amino acid protein tyrosine phosphatase activity /// hydrolase activity /// --- dephosphorylation /// dephosphorylation /// regulation of phosphatase activity protein kinase activity Dr.8194.1.S1_at -1.24535 -1.87623 -1.74076 -2.27768 1 1 1 0.959 0.959 opn1sw1 opsin 1 (co--- signal transduction /// G-protein coupled receptor protein rhodopsin-like receptor activity /// signal transducer activity membrane /// integral to membrane /// integral signaling pathway /// visual perception /// visual perception /// receptor activity /// G-protein coupled receptor activity /// to membrane /// phototransduction /// protein-chromophore linkage /// photoreceptor activity /// photoreceptor activity response to stimulus Dr.8195.1.A1 at -1.06271 1.723147 2.09171 1.23843 1 1 0.975203 1 0.9752 bdnf brain-derive--- brain development growth factor activity --- Dr.820.1.A1 at 7.421597 6.886296 3.305164 -1.00219 0.077529 0.314702 0.62318 1 0.0775 ------Dr.8203.1.S1_at 1.363376 1.686547 2.181738 2.49732 1 1 0.962 0.65638 0.6564 timm9 translocase --- protein targeting to mitochondrion /// transport /// zinc ion zinc ion binding /// metal ion binding mitochondrion /// mitochondrial inner transport /// protein transport /// protein import into membrane /// membrane /// mitochondrial mitochondrial inner membrane /// intracellular protein intermembrane space protein transporter transport across a membrane complex Dr.8209.1.S1_at -2.30826 -1.87109 -1.66108 -2.19203 0.997143 1 1 0.998 0.9971 foxo5 forkhead bo--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding Dr.8209.1.S2_at -1.82919 -2.5326 -2.80247 -2.7475 1 0.545368 0.668763 0.574 0.5454 foxo5 forkhead bo--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding Dr.8214.2.S1_a_at -1.55029 -1.78546 -1.14953 -2.03572 1 1 1 0.997562 0.9976 wt1a wilms tumo--- regulation of transcription, DNA-dependent /// adrenal gland nucleic acid binding /// transcription factor activity /// zinc ion intracellular /// nucleus development /// glomerulus development /// pronephros binding development /// pronephros development Dr.8217.1.S1_at 2.620273 -1.1831 -1.21708 -1.24123 0.827 1 1 1 0.827 meis2.1 myeloid eco--- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription specific DNA binding Dr.8218.1.S1_a_at -1.4178 -1.50461 -1.26538 -2.16532 1 1 1 0.993617 0.9936 eif4e1b eukaryotic t--- translation /// translational initiation RNA 7-methylguanosine cap binding /// RNA binding /// nucleus /// cytoplasm translation initiation factor activity Dr.822.1.S2_at -2.09963 -2.7561 -2.79778 -3.14434 0.999917 0.312432 0.364238 0.20517 0.2052 cxcl12a chemokine --- neuron migration /// immune response /// axon guidance /// cytokine activity /// chemokine activity /// chemoattractant extracellular region axon guidance /// negative regulation of cell proliferation /// activity germ cell migration /// organ morphogenesis /// myofibril assembly /// positive regulation of cell migration /// regulation of axon extension /// fin regeneration /// retinal ganglion cell axon guidance /// retinal ganglion cell axon guidance /// positive regulation of axon extension involved in axon guidance /// induction of positive chemotaxis /// striated muscle cell development

Dr.822.1.S3_at -1.62983 -1.81044 -1.74796 -2.23766 1 1 1 0.9648 0.9648 cxcl12a chemokine --- neuron migration /// immune response /// axon guidance /// cytokine activity /// chemokine activity /// chemoattractant extracellular region axon guidance /// negative regulation of cell proliferation /// activity germ cell migration /// organ morphogenesis /// myofibril assembly /// positive regulation of cell migration /// regulation of axon extension /// fin regeneration /// retinal ganglion cell axon guidance /// retinal ganglion cell axon guidance /// positive regulation of axon extension involved in axon guidance /// induction of positive chemotaxis /// striated muscle cell development

Dr.8251.1.A1 at 2.458805 2.815038 2.526062 2.34104 0.294596 0.184458 0.478872 0.45 0.1845 wu:fi05a09 wu:fi05a09 ------Dr.828.1.A1 at 1.566934 2.361777 2.346725 2.207803 1 0.713719 0.838374 0.862 0.7137 zgc:77115 zgc:77115 --- cell cycle /// mitosis /// cell division --- nucleus Dr.8281.1.S1 at 1.202184 1.655706 2.436526 2.349873 1 1 0.444518 0.740155 0.4445 odz3 odd Oz/ten--- carbohydrate metabolic process exo-alpha-sialidase activity membrane /// integral to membrane Dr.8283.1.S1 at -1.11891 1.303322 1.161102 2.450549 1 1 1 0.784706 0.7847 mibp muscle-spe--- integrin-mediated signaling pathway kinase activity --- Dr.8287.1.S1_a_at 1.90907 3.680982 2.820807 1.850173 1 0.045744 0.587 1 0.0457 jag2 jagged 2 --- liver development /// liver development /// cell calcium ion binding membrane /// integral to membrane /// integral communication /// Notch signaling pathway /// Notch to membrane signaling pathway /// multicellular organismal development /// ventral spinal cord interneuron differentiation /// spinal cord motor neuron differentiation /// pancreas development /// pronephros development

Dr.8290.1.S1_at 2.253176 2.190964 1.804117 1.948649 0.934894 0.99 1 1 0.9349 ptp1b protein tyro--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine phosphatase activity /// hydrolase activity /// --- phosphatase activity Dr.8291.1.S1_at -1.72008 -1.57327 -1.63493 -2.19128 1 1 1 0.962 0.962 acvr2b activin rece--- skeletal development /// neural crest cell migration /// protein protein kinase activity /// protein serine/threonine kinase signal recognition particle, endoplasmic amino acid phosphorylation /// transmembrane receptor activity /// transmembrane receptor protein serine/threonine reticulum targeting /// membrane protein serine/threonine kinase signaling pathway /// kinase activity /// receptor signaling protein serine/threonine negative regulation of signal transduction /// hindbrain kinase activity /// receptor activity /// transforming growth development /// activin receptor signaling pathway /// factor beta receptor activity /// ATP binding /// activin cartilage development receptor activity Dr.8295.1.S1_at -1.50011 -1.42923 -1.14159 2.08922 1 1 1 0.994659 0.9947 kif23 kinesin fam--- cytokinesis /// microtubule-based movement /// embryonic nucleotide binding /// motor activity /// microtubule motor nucleus /// cytoplasm /// microtubule /// cleavage activity /// ATP binding microtubule /// microtubule associated complex /// cleavage furrow Dr.8297.1.S1_at -4.52099 -5.55117 -4.81821 -4.68435 0.225 0.166346 0.205223 0.20964 0.1663 wnt11r wingless-ty--- Wnt receptor signaling pathway, calcium modulating signal transducer activity extracellular region /// proteinaceous pathway /// multicellular organismal development /// heart extracellular matrix development /// Wnt receptor signaling pathway /// cell migration involved in gastrulation Dr.833.1.A1 at -1.56505 1.064068 -1.25305 -2.25518 1 1 1 0.772994 0.773 wu:fa55h04 wu:fa55h04------Dr.8332.1.A1_at -1.33297 -1.20395 1.000097 4.144031 1 1 1 0.057813 0.0578 stka serine/threo--- protein amino acid phosphorylation /// multicellular nucleotide binding /// magnesium ion binding /// nucleic acid nucleus organismal development /// methylation binding /// protein kinase activity /// protein serine/threonine kinase activity /// protein tyrosine kinase activity /// ATP binding /// methyltransferase activity /// kinase activity /// transferase activity /// metal ion binding

Dr.8339.1.S1 at 2.156932 3.004952 4.19327 5.412006 0.855 0.072878 0.0263 0.04292 0.0263 ssrp1a structure s------DNA binding nucleus Dr.834.1.S1 at 1.026483 1.108409 1.351817 2.289656 1 1 1 0.603325 0.6033 zgc:153242 zgc:153242------Dr.835.1.A1 at -1.11504 -2.00236 -2.27428 -1.85119 1 0.997562 0.532226 1 0.5322 zgc:101900 zgc:101900--- pyridoxine biosynthetic process pyridoxal kinase activity --- Dr.8357.1.A1 s at 1.878706 2.792402 2.684344 2.646715 1 0.633769 0.288585 0.163901 0.1639 ------Dr.8377.1.A1_at 2.676106 2.970716 2.658809 2.207448 0.454637 0.623421 0.638306 0.994331 0.4546 zgc:101777 zgc:101777--- endocytosis lipid binding cytoplasm /// lysosome /// cytoskeleton /// plasma membrane /// membrane Dr.838.1.A1_at -2.89633 -2.00818 -2.90124 -1.98831 0.975343 0.999955 0.787 0.999955 0.787 zgc:136440 zgc:136440--- transport /// ion transport /// zinc ion transport /// metal ion zinc ion binding /// metal ion transmembrane transporter membrane /// integral to membrane transport activity Dr.8389.1.S1 at 1.743005 2.752675 2.984202 3.585986 1 0.847274 0.271409 0.162903 0.1629 uqcrq ubiquinol-c------ubiquinol-cytochrome-c reductase activity --- Dr.839.2.S1 a at -3.34207 -2.28303 -3.64712 1.417453 0.999325 0.999917 0.995 1 0.995 ------Dr.8395.1.A1 at 4.194015 3.014157 2.203948 2.083016 0.107731 0.323375 0.995911 0.999955 0.1077 ------Dr.84.1.S1_at 1.703774 2.351877 2.673094 2.533544 1 0.401406 0.160671 0.250802 0.1607 pitrm1 pitrilysin me--- proteolysis /// proteolysis /// zinc ion transport catalytic activity /// metalloendopeptidase activity /// mitochondrion /// mitochondrial matrix /// metalloendopeptidase activity /// endopeptidase inhibitor mitochondrial matrix activity /// metalloendopeptidase inhibitor activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// metal ion binding

Dr.8403.1.A1 at 1.937414 3.163746 3.266431 2.856531 1 0.317159 0.342937 0.400855 0.3172 eif2b1 eukaryotic t--- cellular metabolic process translation initiation factor activity --- Dr.8420.1.A1 at 1.47839 2.307417 1.936383 1.64166 1 0.628424 1 1 0.6284 ------Dr.8483.1.S1 at -2.11335 -2.51091 -2.48941 -1.58493 0.974275 0.407934 0.087682 1 0.0877 LOC791891 similar to D------Dr.8497.1.A1 at -3.90562 -5.38377 -7.05858 -4.36638 0.046158 0.064578 0.009812 0.069617 0.0098 zgc:92069 zgc:92069 ------Dr.8500.1.A1_at 3.914183 4.252531 4.221093 3.046725 0.044967 0.014288 0.035095 0.15141 0.0143 znf622 zinc finger ------nucleic acid binding /// acylphosphatase activity /// zinc ion intracellular binding Dr.8510.1.A1 at 1.544042 2.112983 1.60963 1.154145 1 0.957893 1 1 0.9579 plekha1 pleckstrin h------Dr.8516.1.S1_at -1.6219 -1.81863 -1.46469 -2.2831 1 1 1 0.827463 0.8275 sepp1b selenoprote--- response to oxidative stress /// negative regulation of signal selenium binding extracellular region /// extracellular region /// transduction signal recognition particle, endoplasmic reticulum targeting Dr.8574.1.A1 at -1.86503 -2.1038 -1.96178 -1.95237 1 0.9997 1 0.999955 0.9997 zgc:136955 zgc:136955------Dr.8581.1.S1_at 2.642479 3.85724 3.74349 3.550248 0.308817 0.058178 0.071864 0.067904 0.0582 psme3 proteasome ------proteasome activator activity cytosol /// proteasome activator complex /// protein complex Dr.8587.1.A1_at -2.06131 -1.77306 -2.13741 -1.76355 1 1 0.994863 1 0.9949 igfbp1 insulin-like --- regulation of cell growth /// response to hypoxia /// negative insulin-like growth factor binding extracellular region regulation of cell proliferation Dr.8594.1.S1 at 5.098876 8.652859 9.094978 8.009529 0.045065 0.018907 0.0277 0.031289 0.0189 zgc:100919 zgc:100919--- transport transporter activity /// lipid binding membrane /// integral to membrane Dr.8598.1.A1_at 2.447914 1.850326 2.295181 2.216226 0.944 1 0.99321 0.996758 0.944 pcdh1g1 /// pcdh1g11 /// pprotocadhe --- proteolysis /// calcium ion transport /// homophilic cell aspartic-type endopeptidase activity /// calcium channel membrane adhesion activity /// calcium ion binding /// protein binding /// calcium channel inhibitor activity Dr.8601.1.S1_at 1.647169 2.563013 3.055029 2.45688 1 0.277463 0.264789 0.435361 0.2648 gnaia guanine nu--- signal transduction /// G-protein coupled receptor protein nucleotide binding /// signal transducer activity /// GTP --- signaling pathway binding /// guanyl nucleotide binding Dr.8609.1.A1 at -1.46601 -2.03357 -1.59779 -1.16136 1 0.99994 1 1 0.9999 ------Dr.8654.1.S1 at 1.938685 2.557494 2.145359 2.090688 1 0.670139 0.990731 1 0.6701 sept7a septin 7a --- cell cycle nucleotide binding /// protein binding /// GTP binding septin complex Dr.8654.2.A1 a at 1.702646 2.012213 1.991695 1.640051 1 0.971702 1 1 0.9717 sept7a septin 7a --- cell cycle nucleotide binding /// protein binding /// GTP binding septin complex Dr.8654.2.A1 at 1.795675 2.132953 1.779516 1.595625 1 0.747252 1 1 0.7473 sept7a septin 7a --- cell cycle nucleotide binding /// protein binding /// GTP binding septin complex Dr.8695.1.S1_at 1.391031 2.382372 1.799159 1.254546 1 0.911 1 1 0.911 dusp7 dual specif--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine/serine/threonine phosphatase activity /// --- phosphatase activity /// MAP kinase tyrosine/serine/threonine phosphatase activity Dr.8697.1.A1 at -6.89953 -2.26586 -2.12388 -1.19122 0.260216 0.993564 0.996 1 0.2602 ------Dr.8723.1.S1 at 2.424726 6.988556 12.1497 16.11696 0.861246 0.051795 0.025253 0.018746 0.0187 zgc:92903 zgc:92903 --- cell redox homeostasis ------Dr.8724.1.S1 at 1.732775 2.106335 1.360718 -1.56374 1 0.983791 1 1 0.9838 uchl1 ubiquitin ca--- ubiquitin-dependent protein catabolic process ubiquitin thiolesterase activity /// hydrolase activity intracellular Dr.873.1.A1_at 3.197374 3.76559 3.227649 2.40478 0.145258 0.068436 0.0328 0.353 0.0328 wu:fb02f03 wu:fb02f03 --- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm glycyl-tRNA aminoacylation glycine-tRNA ligase activity /// ATP binding Dr.8744.3.S1_at 1.025096 1.306669 1.643027 2.394558 1 1 1 0.933932 0.9339 actr2 ARP2 actin------nucleotide binding /// actin binding /// protein binding /// ATP cytoplasm /// cytoskeleton /// cell projection binding Dr.8752.1.A1 a at 1.149056 1.465374 2.518249 4.677204 1 1 0.941323 0.194335 0.1943 zgc:77294 zgc:77294 ------Dr.8752.1.A1 x at 1.2974 1.432061 1.722989 3.048699 1 1 1 0.114151 0.1142 zgc:77294 zgc:77294 ------Dr.8752.2.A1 at -2.2474 -1.94798 -1.45682 -2.2591 0.939238 1 1 0.863525 0.8635 zgc:77294 zgc:77294 ------Dr.876.1.S1 at 1.242562 2.528155 2.788829 3.489398 1 0.114151 0.137165 0.023678 0.0237 rpl5a ribosomal p--- translation structural constituent of ribosome /// 5S rRNA binding intracellular /// ribosome Dr.8762.2.S1 at -1.77821 -1.92617 -1.45124 -2.04368 1 1 1 0.99934 0.9993 heatr5a HEAT repe------binding --- Dr.8763.1.A1 at 2.689071 3.577492 3.62522 3.22449 0.075989 0.040766 0.021798 0.033034 0.0218 LOC569455 similar to R------binding --- Dr.8765.1.A1 at -2.44895 -2.90754 -3.40815 -3.38902 0.858248 0.309192 0.047115 0.20295 0.0471 zgc:158309 zgc:158309------catalytic activity membrane Dr.8786.1.A1 at 2.564575 2.377225 -1.00436 1.089505 0.592805 0.889 1 1 0.5928 ------Dr.883.1.A1_at 3.21883 4.243294 3.900127 3.809846 0.161915 0.101711 0.046673 0.036 0.036 dnajc21 DnaJ (Hsp--- zinc ion transport nucleic acid binding /// zinc ion binding /// heat shock protein intracellular binding /// metal ion binding Dr.8833.1.S1_at -1.94078 -3.15042 -3.55732 -2.64998 0.998 0.05553 0.056498 0.332289 0.0555 cdo1 cysteine dio--- iron ion transport /// cellular iron ion homeostasis /// L- iron ion binding /// oxidoreductase activity /// oxidoreductase --- cysteine metabolic process /// oxidation reduction activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen /// cysteine dioxygenase activity /// metal ion binding

Dr.8853.1.S1 at -1.14989 1.695274 3.605569 -1.59686 1 1 0.300393 1 0.3004 fgf10a fibroblast g--- embryonic pectoral fin morphogenesis growth factor activity --- Dr.8857.1.A1 at 1.821046 2.356495 2.161843 1.637898 1 0.718 0.743671 1 0.718 si:ch211-67e16.9 si:ch211-67--- protein modification process tubulin-tyrosine ligase activity --- Dr.8859.1.A1 at 3.904687 3.698829 3.76422 2.095892 0.209405 0.173574 0.271466 0.99994 0.1736 wu:fl23e08 wu:fl23e08 ------Dr.8863.1.A1 at 2.0749 2.422868 2.453081 1.967797 0.997 0.879 0.88561 1 0.879 LOC100002527 similar to S ------Dr.8911.1.A1_at 2.599795 4.122351 3.964166 3.770155 0.54332 0.09433 0.103948 0.124474 0.0943 zgc:92895 zgc:92895 --- protein targeting to mitochondrion /// transport /// zinc ion zinc ion binding /// metal ion binding mitochondrion /// mitochondrial inner transport /// protein transport /// protein import into membrane /// membrane /// mitochondrial mitochondrial inner membrane /// intracellular protein intermembrane space protein transporter transport across a membrane complex Dr.893.2.S1 at 1.780407 2.224953 2.535198 3.417775 1 1 0.857 0.58182 0.5818 ------Dr.8934.2.S1 at -2.86146 -1.56685 -2.93948 -2.79129 0.691441 1 0.422701 0.473815 0.4227 zgc:113208 zgc:113208------Dr.895.1.S1 at 1.486104 2.525047 2.696406 3.263711 1 0.235197 0.152667 0.041078 0.0411 eif3s2 eukaryotic t------translation initiation factor activity --- Dr.895.2.S1 at 1.077162 1.802883 2.169266 2.373998 1 1 0.057802 0.017853 0.0179 rpl14 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome Dr.8959.1.S1 at 1.405842 2.62917 1.343368 1.287036 1 0.677655 1 1 0.6777 zgc:63860 zgc:63860 ------calcium ion binding extracellular region Dr.8969.1.A1 at 1.74339 2.463941 2.489047 3.47677 1 0.715693 0.753777 0.200352 0.2004 ------Dr.899.1.S1 at 1.657782 2.129181 1.988946 2.206547 1 0.999955 1 0.869666 0.8697 slc25a3 solute carri--- transport binding membrane /// integral to membrane Dr.8999.1.S1_at 1.483908 2.089861 2.518278 1.599978 1 1 0.801998 1 0.802 zgc:55702 zgc:55702 --- 'de novo' pyrimidine base biosynthetic process /// pyrimidine catalytic activity /// orotate phosphoribosyltransferase activity --- nucleotide biosynthetic process /// metabolic process /// /// orotidine-5'-phosphate decarboxylase activity /// nucleoside metabolic process transferase activity Dr.9000.1.S1_at 2.161571 2.290322 1.670277 1.447138 0.981731 0.846 1 1 0.846 hsd17b12a hydroxyster--- steroid biosynthetic process /// metabolic process /// lipid catalytic activity /// estradiol 17-beta-dehydrogenase activity endoplasmic reticulum /// endoplasmic biosynthetic process /// oxidation reduction /// binding /// oxidoreductase activity reticulum membrane /// membrane /// integral to membrane Dr.9018.1.A1 at 1.839014 2.528139 2.122837 2.578024 1 0.533358 0.9997 0.668079 0.5334 rab43 RAB43, me------Dr.9024.1.A1_at -1.76396 -1.91694 -2.09878 -2.30638 1 1 0.984 0.621294 0.6213 cdkn1b cyclin-depe--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// nucleus /// cytoplasm tyrosyl-tRNA aminoacylation /// cell cycle arrest tyrosine-tRNA ligase activity /// cyclin-dependent protein kinase inhibitor activity /// ATP binding /// kinase activity /// ligase activity Dr.9044.1.A1_at -1.78877 -1.7881 -1.43113 -2.06254 1 1 1 0.997562 0.9976 myh9 myosin, he--- signal transduction nucleotide binding /// motor activity /// actin binding /// protein intracellular /// myosin complex binding /// ATP binding /// actin filament binding Dr.9066.1.S1_at 1.697596 2.512766 2.307947 1.93854 1 0.540313 0.470609 1 0.4706 srp72 signal reco--- SRP-dependent cotranslational protein targeting to binding /// 7S RNA binding signal recognition particle membrane Dr.907.1.S1_at 1.631526 3.125352 3.878494 5.039375 1 0.348769 0.033872 0.038733 0.0339 rps3a ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.908.1.S1_at 2.237631 3.677559 4.166357 4.670977 0.999 0.192812 0.042 0.049759 0.042 eef2l eukaryotic t--- embryonic development nucleotide binding /// translation elongation factor activity /// --- GTPase activity /// GTP binding Dr.9101.1.S1_at 1.355084 1.951031 1.96282 2.231855 1 1 1 0.799346 0.7993 ube2v2 ubiquitin-co--- post-translational protein modification /// regulation of small conjugating protein ligase activity --- protein metabolic process Dr.9112.1.S1 at 2.015 2.683961 3.074442 2.941207 0.999955 0.312122 0.29936 0.369171 0.2994 zgc:63976 zgc:63976 ------Dr.913.1.S1 at 2.551274 2.893289 2.339173 2.892015 0.721 0.445 0.969 0.609 0.445 tpm4 tropomyosi------Dr.914.1.A1 a at 5.262122 2.013371 1.322129 1.93085 0.271614 1 1 1 0.2716 irf11 interferon r--- regulation of transcription, DNA-dependent transcription factor activity nucleus Dr.9146.1.S1 at -1.00714 -1.52418 -2.06755 -1.22161 1 1 0.99934 1 0.9993 wu:fj59b03 wu:fj59b03 ------Dr.9161.1.A1 at 3.060218 5.07131 4.164979 3.655785 0.063491 0.024335 0.026222 0.013507 0.0135 si:ch211-218c17.2 Si:ch211-2 ------kinase activity --- Dr.917.1.S1_at -1.69453 -2.31028 -1.52492 -2.55848 1 0.75425 1 0.722 0.722 gapdh glyceraldeh --- glucose metabolic process /// glycolysis /// metabolic catalytic activity /// glyceraldehyde-3-phosphate cytoplasm process /// oxidation reduction dehydrogenase (phosphorylating) activity /// binding /// glyceraldehyde-3-phosphate dehydrogenase activity /// oxidoreductase activity /// NAD binding Dr.9196.1.S1 at -1.31842 -1.33898 -1.21183 2.112504 1 1 1 0.995 0.995 zgc:55549 zgc:55549 ------binding --- Dr.9212.1.S1 at -1.44023 -1.31429 1.304839 5.388533 1 1 1 0.056826 0.0568 si:dkey-146n1.1 si:dkey-146------Dr.9217.1.A1 at -1.31843 -1.03266 -1.36347 -2.39756 1 1 1 0.934488 0.9345 ------Dr.9220.1.S1 at 3.445144 3.27762 3.510696 2.839098 0.204159 0.057438 0.127359 0.231834 0.0574 mak16 MAK16 hom--- multicellular organismal development --- nucleus Dr.9223.1.A1 at 1.734188 2.503725 1.774963 1.174861 1 0.598 1 1 0.598 wu:fc18f10 wu:fc18f10 ------Dr.9263.1.A1 at -1.74061 -1.96995 -3.36748 -2.1476 1 1 0.536 0.999955 0.536 wu:fk68g08 wu:fk68g08------Dr.9268.1.A1 at 1.376633 -1.51232 -1.78151 -2.31366 1 1 1 0.900674 0.9007 LOC100151220 similar to m------Dr.9283.1.A1 at 2.098357 3.294491 2.998639 2.215689 0.966 0.114743 0.269 0.896804 0.1147 ------Dr.9285.1.S1_at 1.035348 1.514659 1.689087 2.036282 1 1 1 0.993 0.993 sdhda succinate d--- tricarboxylic acid cycle iron ion binding /// heme binding mitochondrial envelope /// integral to membrane Dr.9288.1.S1_at -1.33166 -1.90798 -2.32427 -1.7306 1 1 0.977642 1 0.9776 igf2b insulin-like --- negative regulation of signal transduction hormone activity extracellular region /// signal recognition particle, endoplasmic reticulum targeting Dr.930.1.S1 at 1.331808 2.438736 2.593222 3.088328 1 0.538402 0.72621 0.146819 0.1468 mrpl28 mitochondr--- regulation of transcription transcription factor activity nucleus /// ribosome Dr.930.2.A1 at 1.547748 2.150801 2.152559 2.198492 1 0.994696 0.986747 0.727 0.727 mrpl28 mitochondr--- regulation of transcription transcription factor activity nucleus /// ribosome Dr.9300.1.A1 at 2.411524 2.797359 2.557317 3.79518 0.964187 0.857 0.978695 0.467388 0.4674 wu:fc14e10 wu:fc14e10------Dr.9315.1.A1_at 2.270215 3.515563 3.441189 3.342901 0.999955 0.243914 0.086633 0.09539 0.0866 ddx27 DEAD (Asp------nucleotide binding /// nucleic acid binding /// helicase activity --- /// ATP binding /// ATP-dependent helicase activity /// hydrolase activity Dr.9323.1.A1 at -1.24295 -1.81589 -2.82056 -2.03707 1 1 0.374791 0.992624 0.3748 ------Dr.9329.1.S1 at 1.593293 3.075917 3.085659 3.638842 1 0.359 0.518208 0.221147 0.2211 rnaseka ribonucleas------Dr.9374.1.A1 at -1.62826 -1.65537 -1.92445 -2.06196 1 1 1 0.999917 0.9999 si:ch211-184m19.1 si:ch211-18------Dr.941.1.S1 at 2.099236 2.880975 2.578643 2.394399 0.970422 0.15978 0.282779 0.611621 0.1598 caprin1 cell cycle a------Dr.9419.1.A1 at 1.674855 2.169501 1.826631 1.766282 1 0.991909 1 1 0.9919 ------Dr.9425.1.A1 at -1.09433 -2.44833 -2.20633 -2.08552 1 0.817879 0.626752 0.979 0.6268 ak5 adenylate k------Dr.9446.1.A1_a_at 2.245896 3.782728 3.81858 4.399634 0.60936 0.013507 0.075552 0.009169 0.0092 pxn paxillin --- somitogenesis /// zinc ion transport /// cell-matrix adhesion protein binding /// zinc ion binding /// metal ion binding cytoskeleton /// embryonic development Dr.945.1.S1_at 1.216776 2.510224 2.287706 2.820815 1 0.286166 0.776236 0.116234 0.1162 pgam1 phosphogly--- glycolysis /// metabolic process catalytic activity /// intramolecular transferase activity, --- phosphotransferases Dr.9450.1.A1 at 2.093251 1.659724 1.301974 -1.02301 0.995 1 1 1 0.995 zgc:63724 zgc:63724 ------Dr.9457.1.A1_at -5.90441 -3.50051 -2.83229 -1.2046 0.010979 0.260437 0.700608 1 0.011 egln3 egl nine ho--- protein metabolic process iron ion binding /// oxidoreductase activity /// oxidoreductase --- activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Dr.9460.1.S1 at 1.15451 -1.75018 -2.06508 -1.48105 1 1 0.996674 1 0.9967 ------Dr.9464.1.A1 at 2.722874 3.210717 2.002657 1.741683 0.295743 0.046032 1 1 0.046 zgc:92107 zgc:92107 --- signal transduction protein binding intracellular /// cytoskeleton Dr.947.1.S1_at 1.479341 2.799313 2.788917 2.476694 1 0.456256 0.166652 0.694348 0.1667 rars arginyl-tRN--- translation /// tRNA aminoacylation for protein translation /// nucleotide binding /// aminoacyl-tRNA ligase activity /// cytoplasm arginyl-tRNA aminoacylation arginine-tRNA ligase activity /// ATP binding /// ligase activity

Dr.9481.1.A1 at 1.588816 2.432536 2.484083 2.408513 1 0.728426 0.321128 0.411583 0.3211 zgc:92182 zgc:92182 ------Dr.9484.1.A1 at 1.136621 1.712743 3.95097 4.561229 1 1 0.045348 0.040027 0.04 zgc:100829 zgc:100829------Dr.9489.1.S1 a at 2.521961 3.225229 2.742571 2.536978 0.823 0.376361 0.68364 0.908 0.3764 LOC565062 hypothetica------Dr.9510.1.A1 at 1.085013 2.455405 1.851394 2.584964 1 0.904713 1 0.708424 0.7084 ------Dr.9529.1.A1_at 2.855014 2.983682 2.85394 2.773162 0.373178 0.401406 0.383683 0.42338 0.3732 zgc:77291 zgc:77291 --- regulation of transcription, DNA-dependent /// regulation of DNA binding /// transcription factor activity /// sequence- nucleus transcription specific DNA binding /// protein dimerization activity

Dr.953.2.S1_at 1.418315 2.74552 3.123699 4.199712 1 0.651496 0.369593 0.087336 0.0873 si:dkey-66d18.1 si:dkey-66d--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.955.1.A1 at 2.814362 3.356209 2.989855 2.092807 0.052 0.025448 0.031587 0.999955 0.0254 LOC562529 similar to F------Dr.9550.1.S1_at -1.16281 -1.23475 1.321275 3.289755 1 1 1 0.205479 0.2055 zgc:153687 zgc:153687--- post-translational protein modification /// regulation of ligase activity /// small conjugating protein ligase activity --- protein metabolic process Dr.9552.1.A1 at -2.38658 -2.28816 -1.97175 -1.39222 0.912756 0.970026 1 1 0.9128 ------Dr.9556.1.S1_at 1.535183 2.295334 1.93463 2.161744 1 0.940843 1 0.999325 0.9408 agk acylglycero --- activation of protein kinase C activity nucleotide binding /// diacylglycerol kinase activity /// ATP mitochondrion /// membrane /// mitochondrial binding /// kinase activity /// transferase activity /// membrane acylglycerol kinase activity Dr.9560.1.A1 at -1.00725 1.042614 -1.38446 -2.07377 1 1 1 0.994696 0.9947 LOC565706 similar to p ------Dr.9565.1.S1 at 3.528201 3.392244 2.566709 1.588475 0.524423 0.372043 0.925 1 0.372 enc1 ectodermal------protein binding --- Dr.9582.1.A1_at 1.436247 2.306556 1.237304 1.237709 1 0.283163 1 1 0.2832 zgc:158254 zgc:158254--- protein metabolic process iron ion binding /// calcium ion binding /// oxidoreductase --- activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Dr.9585.1.A1 at -3.06179 -1.57469 -2.08164 1.334936 0.593782 1 0.994 1 0.5938 ------Dr.96.1.A1 at 103.616 125.6377 90.95321 45.73501 0.00375 0.002 0.002612 0.004171 0.002 LOC570832 similar to c------Dr.9611.1.A1 at 1.246119 2.225329 1.506724 1.544805 1 0.866276 1 1 0.8663 si:ch211-241e15.2 si:ch211-24------nucleotide binding /// nucleic acid binding --- Dr.9617.1.A1 at 34.93821 39.15782 28.46099 21.29996 0.021125 0.018746 0.024136 0.028592 0.0187 socs3b suppressor --- intracellular signaling cascade protein binding --- Dr.9619.1.A1 at -2.99798 -5.57895 -6.0199 -5.37468 0.101828 0.031726 0.012605 0.022806 0.0126 ------Dr.9622.1.S1_at 1.389313 2.331156 2.077788 3.317481 1 0.91 0.993617 0.168676 0.1687 zgc:92726 zgc:92726 --- ubiquitin-dependent protein catabolic process endopeptidase activity /// threonine-type endopeptidase cytosol /// proteasome core complex /// protein activity /// endopeptidase inhibitor activity /// peptidase complex activity /// hydrolase activity Dr.9628.1.A1 at 1.715172 2.878046 2.883565 2.481613 1 0.245713 0.470412 0.864358 0.2457 alg6 asparagine--- protein amino acid N-linked glycosylation transferase activity /// glucosyltransferase activity endoplasmic reticulum Dr.964.1.A1 at 2.688032 2.84379 2.356846 1.637239 0.445781 0.335 0.794 1 0.335 ------Dr.9654.1.A1_at 1.557771 1.972877 2.50805 2.719184 1 0.99934 0.514 0.272 0.272 ppia peptidylpro--- protein folding peptidyl-prolyl cis-trans isomerase activity /// isomerase --- activity Dr.9659.1.S1_at 1.977844 2.655785 2.786785 3.014244 1 0.243265 0.267 0.152394 0.1524 gng5 guanine nu--- nucleosome assembly /// G-protein coupled receptor protein DNA binding /// signal transducer activity nucleosome /// nucleus /// chromosome /// signaling pathway heterotrimeric G-protein complex Dr.9661.1.A1_at -1.33944 -2.13342 -2.22581 -2.15439 1 0.992 0.974942 0.989 0.9749 tbxas1 thromboxan--- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// electron carrier --- iron ion homeostasis /// oxidation reduction activity /// oxidoreductase activity /// oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen /// heme binding /// metal ion binding

Dr.9667.1.S1 at 2.771825 4.760896 3.730428 2.867456 0.43 0.048611 0.187886 0.345947 0.0486 dnajb11 DnaJ (Hsp--- protein folding heat shock protein binding /// unfolded protein binding --- Dr.967.1.S1_at 16.73622 184.6788 217.1813 198.8531 0.148903 0.001643 0.001256 0.002202 0.0013 mmp9 matrix meta--- proteolysis /// calcium ion transport /// zinc ion transport /// catalytic activity /// metalloendopeptidase activity /// proteinaceous extracellular matrix metabolic process endopeptidase inhibitor activity /// calcium channel activity /// calcium ion binding /// metalloendopeptidase inhibitor activity /// peptidase activity /// metallopeptidase activity /// zinc ion binding /// hydrolase activity /// calcium channel inhibitor activity /// metal ion binding

Dr.9682.1.A1 at -1.45198 -1.75345 -1.42721 -2.02774 1 1 1 0.99934 0.9993 LOC100002476 similar to V------binding /// sugar binding --- Dr.969.1.S1 at 1.338595 4.653593 7.311535 4.132888 1 0.141292 0.049794 0.067705 0.0498 sept9a septin 9a --- cell cycle nucleotide binding /// GTP binding --- Dr.9709.1.A1 at -1.40241 -1.59707 -1.36516 -2.15189 1 1 1 0.971687 0.9717 ------Dr.9714.1.S1 at 1.198768 1.17306 1.392382 2.254982 1 1 1 0.99934 0.9993 zgc:100908 zgc:100908------Dr.9715.1.S1_a_at 2.511065 3.839632 3.464924 2.552624 0.539575 0.13276 0.038316 0.208723 0.0383 exosc4 exosome co--- RNA processing 3'-5'-exoribonuclease activity /// RNA binding /// exonuclease --- activity Dr.9715.2.S1_x_at 1.778855 2.343833 2.432347 1.761918 1 0.963 0.605247 1 0.6052 exosc4 exosome co--- RNA processing 3'-5'-exoribonuclease activity /// RNA binding /// exonuclease --- activity Dr.9715.3.S1_a_at 2.088725 2.715225 2.308815 2.284424 1 0.643213 0.426 0.510125 0.426 exosc4 exosome co--- RNA processing 3'-5'-exoribonuclease activity /// RNA binding /// exonuclease --- activity Dr.9723.1.A1_at 1.694996 2.780834 2.06146 1.270212 1 0.244957 1 1 0.245 dusp7 dual specif--- protein amino acid dephosphorylation /// dephosphorylation protein tyrosine/serine/threonine phosphatase activity /// --- phosphatase activity /// MAP kinase tyrosine/serine/threonine phosphatase activity Dr.9743.1.S1 at -1.32928 1.226864 1.332022 3.417252 1 1 1 0.202192 0.2022 hmgb2 high-mobili--- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.9743.2.S1 a at -1.63383 1.508455 1.658099 5.91771 1 1 1 0.037711 0.0377 hmgb2 /// LOC100151229 high-mobili--- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.9746.1.S1_a_at 1.063877 -1.04172 2.121008 7.519648 1 1 0.98838 0.021333 0.0213 rrm1 ribonucleot--- DNA replication /// oxidation reduction nucleotide binding /// catalytic activity /// ribonucleoside- cytoplasm /// ribonucleoside-diphosphate diphosphate reductase activity /// protein binding /// ATP reductase complex binding /// oxidoreductase activity

Dr.9746.11.A1_at -1.25655 -1.31115 -1.10155 2.035223 1 1 1 0.9997 0.9997 si:busm1-234g15.1 Si:busm1-2--- protein modification process ubiquitin-protein ligase activity /// protein binding /// zinc ion intracellular binding Dr.9746.12.S1 at -1.4438 -1.31925 -1.07317 2.029095 1 1 1 0.99934 0.9993 zgc:123215 zgc:123215--- regulation of transcription, DNA-dependent DNA binding chromatin /// nucleus Dr.9746.13.S1_at 1.115645 1.059145 -1.14279 4.017653 1 1 1 0.310507 0.3105 si:busm1-234g15.1 si:busm1-2 --- protein modification process ubiquitin-protein ligase activity /// protein binding /// zinc ion intracellular binding Dr.9746.3.S1_at 1.756368 2.697056 2.82798 3.299205 1 0.608 0.592486 0.518 0.518 rpl19 ribosomal p--- translation structural constituent of ribosome intracellular /// ribosome /// ribonucleoprotein complex Dr.9746.7.A1 at -1.4085 -2.23432 -1.27377 1.258538 1 0.734 1 1 0.734 wu:fc51f04 wu:fc51f04 ------Dr.9746.8.S1_at 4.28708 6.657369 6.773536 6.884607 0.102515 0.013336 0.01219 0.012702 0.0122 zgc:86706 zgc:86706 --- transport iron ion binding /// electron carrier activity /// heme binding /// mitochondrion /// mitochondrial respiratory metal ion binding chain /// mitochondrial matrix Dr.9753.1.A1 at 1.493023 1.714441 1.597604 2.109372 1 1 1 0.987827 0.9878 ------Dr.9766.1.S1_at 1.130576 2.040137 2.646191 4.944958 1 1 0.27 0.021468 0.0215 cox5ab cytochrome --- spinal cord motor neuron differentiation /// embryonic organ cytochrome-c oxidase activity /// cytochrome-c oxidase --- development activity Dr.9798.1.A1_at 2.092834 3.134479 3.414863 2.138635 0.997322 0.109969 0.050468 0.978514 0.0505 yars tyrosyl-tRN--- translation /// tRNA aminoacylation for protein translation /// tRNA binding /// nucleotide binding /// RNA binding /// cytoplasm tyrosyl-tRNA aminoacylation aminoacyl-tRNA ligase activity /// tyrosine-tRNA ligase activity /// ATP binding /// ligase activity Dr.98.1.A1_at 1.751265 2.060131 1.969843 2.041482 1 0.999 1 1 0.999 pcnt1 pericentrin --- transport /// protein transport /// mRNA transport /// --- nucleus /// nuclear pore /// membrane /// intracellular protein transport across a membrane nuclear membrane Dr.9809.2.S1_at -1.03539 1.302742 2.920665 5.532806 1 1 0.312627 0.196562 0.1966 uhrf1 ubiquitin-lik--- lens development in camera-type eye /// protein modification protein binding /// zinc ion binding /// metal ion binding --- process /// zinc ion transport /// organ regeneration

Dr.9814.1.A1 at 1.252713 1.753056 2.029933 2.236014 1 1 1 0.954624 0.9546 zgc:92862 zgc:92862 --- translation structural constituent of ribosome intracellular /// ribosome Dr.9814.2.S1 at 1.317156 1.978596 2.193368 2.608787 1 1 0.998 0.133 0.133 zgc:92862 zgc:92862 --- translation structural constituent of ribosome intracellular /// ribosome Dr.982.1.S1_at 1.665241 3.641657 4.300187 2.990811 1 0.061583 0.027488 0.113307 0.0275 tmem49 transmemb------membrane /// integral to membrane /// ER- Golgi intermediate compartment membrane

Dr.9824.1.A1 at -1.47063 -1.75213 -2.11519 -2.25426 1 1 0.99556 0.96 0.96 wu:fk58b12 wu:fk58b12------Dr.9827.1.S1 at 2.118584 1.308702 1.390053 1.522399 0.996244 1 1 1 0.9962 prom1b prominin 1 ------integral to membrane Dr.9835.1.S1 at 2.704033 -1.92484 -2.7875 -3.33701 0.970422 1 0.944 0.771468 0.7715 gngt1 guanine nu--- G-protein coupled receptor protein signaling pathway signal transducer activity heterotrimeric G-protein complex Dr.9836.1.S1_at -1.29679 -1.85882 -2.12602 -2.36417 1 1 0.994295 0.953348 0.9533 nme2l non-metast--- GTP biosynthetic process /// UTP biosynthetic process /// nucleotide binding /// nucleoside diphosphate kinase activity --- CTP biosynthetic process /// ATP binding /// kinase activity /// transferase activity

Dr.9841.1.A1_at -3.3805 -3.53966 -6.65483 -4.3779 0.665622 0.333277 0.138381 0.326484 0.1384 pde6c phosphodie--- signal transduction catalytic activity /// 3',5'-cyclic-nucleotide phosphodiesterase --- activity Dr.9847.1.A1 at -1.34226 -2.466 -3.13481 -2.59214 1 0.964549 0.669906 0.94268 0.6699 pdc1 phosducin ------Dr.9847.2.A1 at -1.81889 -3.18249 -3.20282 -3.22681 1 0.231 0.334302 0.274958 0.231 pdc1 phosducin ------Dr.9849.1.A1_at -1.05482 -1.47331 -2.05764 -1.92038 1 1 0.994295 0.999917 0.9943 zgc:77060 zgc:77060 --- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.9850.1.A1_at -1.30384 -2.50074 -2.82211 -1.779 1 0.983888 0.929974 1 0.93 opn1mw2 opsin 1 (co--- signal transduction /// G-protein coupled receptor protein rhodopsin-like receptor activity /// signal transducer activity membrane /// integral to membrane signaling pathway /// visual perception /// phototransduction /// receptor activity /// G-protein coupled receptor activity /// /// protein-chromophore linkage /// response to stimulus photoreceptor activity

Dr.9851.1.A1 at 1.079596 -1.91445 -1.87432 -2.22906 1 1 1 0.839 0.839 ------Dr.9853.1.A1_at -1.33785 -2.18275 -2.43084 -2.42256 1 0.989 0.870805 0.827598 0.8276 pde6a phosphodie--- signal transduction catalytic activity /// 3',5'-cyclic-nucleotide phosphodiesterase --- activity Dr.9871.1.A1_at -1.01499 -1.96605 -2.58671 -2.18493 1 1 0.821 0.975343 0.821 rcv1 recoverin --- calcium ion transport calcium channel activity /// calcium ion binding /// calcium --- ion binding /// calcium channel inhibitor activity

Dr.9875.1.A1 at 1.070411 -1.55068 -1.78233 -2.86491 1 1 1 0.154393 0.1544 ------Dr.988.1.S1 at -1.72246 -2.04025 -1.70399 -1.15465 1 0.9997 1 1 0.9997 dci dodecenoy --- metabolic process catalytic activity --- Dr.9881.1.S1_at -2.92672 -3.00854 -3.20845 -3.73804 0.649631 0.202936 0.156292 0.09478 0.0948 guanine nu--- signal transduction /// G-protein coupled receptor protein nucleotide binding /// signal transducer activity /// GTP --- signaling pathway /// detection of light stimulus involved in binding /// guanyl nucleotide binding visual perception Dr.9881.2.A1_at -2.03062 -2.8349 -3.98123 -4.31817 1 0.517789 0.174406 0.168277 0.1683 gnat2 guanine nu--- signal transduction /// G-protein coupled receptor protein nucleotide binding /// signal transducer activity /// GTP --- signaling pathway /// detection of light stimulus involved in binding /// guanyl nucleotide binding visual perception Dr.9883.1.S1 at -2.91457 -2.85979 -2.84913 -2.73843 0.400855 0.458438 0.36 0.695237 0.36 wu:fk54a10 Wu:fk54a1 ------Dr.9888.1.A1 at -1.72187 -1.97155 -1.75261 -2.11797 1 1 1 0.831 0.831 ------Dr.989.1.S1 at 1.725993 2.652531 2.154087 2.218891 1 0.4 0.991 0.853 0.4 zgc:56419 zgc:56419 --- transport transporter activity /// binding --- Dr.9890.1.A1 at -2.63798 -2.87323 -3.5379 -3.79757 0.987 0.840625 0.605518 0.540428 0.5404 zgc:193593 zgc:193593------Dr.9893.1.A1 at -1.20276 -1.90878 -2.13911 -2.12258 1 1 0.974234 0.983791 0.9742 ------Dr.9894.1.A1 at 1.296568 -2.51009 -3.38375 -3.74554 1 0.869666 0.311289 0.271276 0.2713 wu:fk56b02 wu:fk56b02------Dr.9896.1.A1_at -2.74631 -2.14317 -2.9825 -3.65025 0.785 0.994186 0.019 0.101208 0.019 si:ch211-195b13.1 si:ch211-19--- protein amino acid phosphorylation /// cell communication nucleotide binding /// protein kinase activity /// protein --- serine/threonine kinase activity /// protein binding /// ATP binding /// kinase activity /// transferase activity /// phosphoinositide binding Dr.9899.1.S1_at 1.044713 -2.19027 -2.58675 -3.14773 1 0.997322 0.740649 0.267 0.267 guanine nu--- signal transduction /// G-protein coupled receptor protein nucleotide binding /// signal transducer activity /// GTP --- signaling pathway binding /// guanyl nucleotide binding Dr.9899.1.S2_at 1.69914 -1.43301 -1.8196 -2.39834 1 1 1 0.921 0.921 gnat1 guanine nu--- signal transduction /// G-protein coupled receptor protein nucleotide binding /// signal transducer activity /// GTP --- signaling pathway binding /// guanyl nucleotide binding Dr.9901.1.S1 at 4.831764 3.122597 3.288586 2.640238 0.1 0.332289 0.289416 0.994696 0.1 ------Dr.9903.1.A1 at 1.099968 -1.55558 -2.07053 -1.70694 1 1 0.994331 1 0.9943 gnb5 guanine nu------Dr.9912.1.A1 at 1.003606 -1.68219 -2.14662 -2.31884 1 1 1 0.528445 0.5284 wu:fk57g06 wu:fk57g06------Dr.9914.1.S1 at 4.588758 7.813396 5.866508 4.680078 0.053933 0.040218 0.045545 0.050698 0.0402 zgc:92746 zgc:92746 ------Dr.9917.1.S1_at 2.258011 -1.08698 -1.96161 -1.72963 0.897347 1 0.99994 1 0.8973 gad1 glutamate d--- gamma-aminobutyric acid biosynthetic process /// carboxylic catalytic activity /// glutamate decarboxylase activity /// lyase --- acid metabolic process /// neurotransmitter biosynthetic activity /// carboxy-lyase activity /// pyridoxal phosphate process binding Dr.9918.1.S1 at -1.1926 -1.87805 -2.22035 -2.10348 1 1 0.568 0.408139 0.4081 slmap sarcolemm------Dr.9920.1.A1_at 8.08481 -1.71045 -1.38529 -1.52343 0.156123 1 1 1 0.1561 wu:fk63e10 wu:fk63e10--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

Dr.9922.1.S1 at -1.80254 -2.73509 -3.3199 -3.03756 1 0.695447 0.424695 0.520139 0.4247 gnb3 guanine nu------extracellular region Dr.9925.1.S1_at -2.27622 -2.42849 -2.86195 -2.40537 0.64315 0.273 0.173228 0.752992 0.1732 zgc:73359 zgc:73359 --- visual perception 3',5'-cyclic-nucleotide phosphodiesterase activity /// cGMP --- binding Dr.9928.1.S1 at -1.31658 -2.61269 -4.09743 -2.88805 1 0.602 0.206064 0.3747 0.2061 dap1b death asso------Dr.994.3.S1_at 1.987019 2.913414 3.621313 4.666025 1 0.413471 0.083199 0.044714 0.0447 cox7a2 cytochrome ------cytochrome-c oxidase activity /// electron carrier activity mitochondrial respiratory chain

Dr.9953.1.S1 at -2.15289 -1.66417 -2.37039 -2.16205 0.999955 1 0.793 0.937651 0.793 sb:cb98 sb:cb98 ------Dr.9954.1.A1 at 1.202013 1.922591 2.125117 2.161589 1 1 0.9997 0.992624 0.9926 spag1 sperm asso------binding --- Dr.9972.1.S1 at -2.11461 -3.18988 -2.33453 -3.54846 0.996789 0.588807 0.970422 0.529 0.529 wu:fb71e04 wu:fb71e04------Dr.9981.1.S1 at -3.10033 -2.55748 -2.90279 -2.56134 0.628 0.680695 0.429859 0.712358 0.4299 wu:fk66f10 wu:fk66f10 ------Dr.9981.2.S1 at -3.80646 -2.57766 -3.46376 -2.91074 0.225 0.532226 0.210051 0.285314 0.2101 wu:fk66f10 wu:fk66f10 ------Dr.9986.1.A1_at 2.81604 1.46716 1.289804 -1.04886 0.708301 1 1 1 0.7083 grtp1a growth horm--- regulation of Rab GTPase activity GTPase activator activity /// Rab GTPase activator activity /// extracellular region /// intracellular hormone activity Dr.9988.1.A1 at 2.3734 5.160158 2.624342 2.058202 0.592827 0.028 0.752717 1 0.028 wu:fd44f11 wu:fd44f11 ------DrAffx.1.1.S1_x_at -1.77811 -2.12389 -1.48135 -2.78122 1 0.99994 1 0.586 0.586 cebp1 CCAAT/en--- regulation of transcription, DNA-dependent DNA binding /// transcription factor activity /// sequence- nucleus specific DNA binding /// protein dimerization activity

DrAffx.1.15.S1 at -1.81559 -1.97341 -1.77439 -2.29329 1 1 1 0.994863 0.9949 veph ventricular --- brain development /// ear morphogenesis --- plasma membrane /// membrane DrAffx.1.18.S1 at -1.43404 -2.73817 -1.76092 -1.44409 1 0.358453 1 1 0.3585 negr1 neuronal gr------protein binding /// identical protein binding --- DrAffx.1.4.S1 at -1.10522 -3.97052 -7.28534 -6.30912 1 0.386645 0.062608 0.117397 0.0626 tnr tenascin R --- signal transduction /// axon guidance receptor binding --- DrAffx.1.45.S1 at -2.1193 -2.16902 -1.81132 -2.88576 0.999955 0.999955 1 0.949741 0.9497 znfl1 zinc finger------nucleic acid binding /// zinc ion binding --- DrAffx.1.53.S1 at 1.152216 1.88909 2.096951 2.642229 1 1 0.996 0.480426 0.4804 zgc:65749 zgc:65749 ------DrAffx.1.74.S1 at -1.70567 -1.70715 -1.59267 -2.12086 1 1 1 0.98016 0.9802 sepw2b selenoprote--- cell redox homeostasis selenium binding --- DrAffx.1.75.S1_at -1.19012 -1.35209 -1.7185 -2.21159 1 1 1 0.993564 0.9936 fgf24 fibroblast g--- dorsal/ventral pattern formation /// exocrine pancreas growth factor activity --- development /// embryonic heart tube development /// embryonic pectoral fin morphogenesis /// negative regulation of endodermal cell fate specification DrAffx.1.79.S1_at -1.81971 -2.20722 -1.70525 -2.31674 1 0.817398 1 0.59681 0.5968 ifn1 interferon 1 --- defense response /// response to virus /// response to virus cytokine activity /// hematopoietin/interferon-class (D200- extracellular region /// extracellular space /// response to exogenous dsRNA /// response to arsenic /// domain) cytokine receptor binding regulation of defense response to virus by host /// defense response to virus DrAffx.2.105.A1 at 1.144555 1.02931 1.262183 2.791105 1 1 1 0.557228 0.5572 ------DrAffx.2.105.S1 at 1.190285 1.452051 2.048636 11.87043 1 1 0.972632 0.065374 0.0654 ------DrAffx.2.22.S1_at -2.02146 -2.26964 -1.53338 -2.63416 1 0.404 1 0.428 0.404 esrrg estrogen-re--- transcription /// transcription, DNA-dependent /// DNA binding /// transcription factor activity /// transcription nucleus /// nucleus transcription termination /// regulation of transcription, DNA- factor activity /// steroid hormone receptor activity /// receptor dependent /// zinc ion transport /// transcription activity /// ligand-dependent nuclear receptor activity /// antitermination steroid binding /// zinc ion binding /// sequence-specific DNA binding /// metal ion binding DrAffx.2.42.S1_s_at -1.76639 -1.99227 -1.23057 -2.20569 1 0.999955 1 0.964549 0.9645 pyya peptide YY --- neuropeptide signaling pathway /// negative regulation of hormone activity /// protein binding /// type 2 neuropeptide Y extracellular region /// signal recognition signal transduction receptor binding /// type 2 neuropeptide Y receptor binding particle, endoplasmic reticulum targeting

DrAffx.2.43.A1_at -1.80718 -2.07895 -1.54799 -2.16336 1 0.999955 1 0.999 0.999 ------transcription /// regulation of transcription, DNA-dependent nucleotide binding /// rhodopsin-like receptor activity /// nucleus /// plasma membrane /// membrane /// /// mRNA processing /// apoptosis /// signal transduction /// nucleic acid binding /// DNA binding /// RNA binding /// integral to membrane /// ribonucleoprotein G-protein coupled receptor protein signaling pathway /// signal transducer activity /// receptor activity /// G-protein complex RNA splicing coupled receptor activity /// protein binding DrAffx.2.59.S1_at -1.96028 -1.94282 -1.85393 -2.23035 1 1 1 0.994696 0.9947 cyp26c1 cytochrome --- heme biosynthetic process /// iron ion transport /// cellular monooxygenase activity /// iron ion binding /// electron carrier --- iron ion homeostasis /// rhombomere 4 morphogenesis /// activity /// heme binding /// metal ion binding hindbrain development /// retinoic acid metabolic process

DrAffx.2.70.A1 s at 1.550315 1.946637 2.116381 2.252451 1 1 0.983443 0.79273 0.7927 ------DrAffx.2.72.S1_at -1.60895 -2.24853 -2.09099 -2.52622 1 0.956 0.999955 0.817 0.817 LOC791965 hypothetica--- oxidation reduction monooxygenase activity /// iron ion binding /// electron carrier --- activity /// oxidoreductase activity /// heme binding /// metal ion binding DrAffx.2.78.S1_at -1.8937 -2.31721 -1.77295 -2.24952 1 0.741866 1 0.938674 0.7419 tnfsf10l2 tumor necr--- immune response cytokine activity /// tumor necrosis factor receptor binding extracellular space /// membrane /// integral to membrane DrAffx.3.1.A1 at -4.4695 -3.16955 -3.44167 -2.94395 0.876 0.96775 0.886199 0.988 0.876 LOC100151188 hypothetica------DrAffx.3.1.S1 at -3.03023 -2.32492 -2.75306 -2.27524 0.991736 0.999917 0.980511 0.999955 0.9805 ------