sign in sign up
<<
Home , ACTG2, ADCY2, ADCY8, ADP ribosylation factor, AK2, AKAP13

Supplementary Table 2. Differentially Expressed following Sham treatment relative to Untreated Controls Fold Change

Accession Name Symbol 3 h 12 h NM_013121 CD28 antigen Cd28 12.82 BG665360 FMS-like tyrosine 1 Flt1 9.63 NM_012701 Adrenergic , beta 1 Adrb1 8.24 0.46 U20796 subfamily 1, group D, member 2 Nr1d2 7.22 NM_017116 2 Capn2 6.41 BE097282 binding , alpha 12 Gna12 6.21 NM_053328 Basic helix-loop-helix domain containing, class B2 Bhlhb2 5.79 NM_053831 Guanylate 2f Gucy2f 5.71 AW251703 receptor superfamily, member 12a Tnfrsf12a 5.57 NM_021691 Twist homolog 2 (Drosophila) Twist2 5.42 NM_133550 , IgE, low affinity II, alpha polypeptide Fcer2a 4.93 NM_031120 Signal sequence receptor, gamma Ssr3 4.84 NM_053544 Secreted -related protein 4 Sfrp4 4.73 NM_053910 Pleckstrin , Sec7 and coiled/coil domains 1 Pscd1 4.69 BE113233 Suppressor of signaling 2 Socs2 4.68 NM_053949 voltage-gated channel, subfamily H (eag- Kcnh2 4.60 related), member 2 NM_017305 Glutamate , modifier subunit Gclm 4.59

NM_017309 Protein phospatase 3, regulatory subunit B, alpha Ppp3r1 4.54 isoform,type 1 NM_012765 5-hydroxytryptamine (serotonin) receptor 2C Htr2c 4.46

NM_017218 V-erb-b2 erythroblastic viral homolog Erbb3 4.42 3 (avian) AW918369 protein 191 Zfp191 4.38

NM_031034 Guanine nucleotide binding protein, alpha 12 Gna12 4.38 NM_017020 6 receptor Il6r 4.37 AJ002942 , beta Rarb 4.35 X70706 Plastin 3 (T-isoform) Pls3 4.13 AJ000556 1 Jak1 4.08 NM_053679 DNA fragmentation factor, alpha subunit Dffa 4.08 NM_057118 Contactin 1 Cntn1 4.07 NM_017247 channel, voltage-gated, type 10, alpha Scn10a 3.96 polypeptide NM_031563 sensitive element binding protein 1 Nsep1 3.84

AF038388 FYVE, RhoGEF and PH domain containing 4 Fgd4 3.83 Y00697 Cathepsin L Ctsl 3.81 NM_031615 Zinc finger protein 148 Znf148 3.69 NM_019306 FMS-like 1 Flt1 3.67 NM_019378 SNAP25-interacting protein Snip 3.62 NM_031535 Bcl2-like 1 Bcl2l1 3.59

1

Downloaded from iovs.arvojournals.org on 09/30/2021 M92340 signal transducer Il6st 3.57 NM_017031 4B Pde4b 3.55 NM_012866 Nuclear factor-Y gamma Nfyc 3.45 NM_013226 L32 Rpl32 3.43 NM_031018 Activating 2 Atf2 3.37 NM_013108 , beta 3 Adrb3 3.34 NM_012863 Muscle, intestine and expression 1 Mist1 3.29 M13979 2 (facilitated transporter), Slc2a1 3.28 member 1 NM_130739 Acyl-CoA synthetase long-chain family member 6 Acsl6 3.27

NM_019376 Tyrosine 3-monooxgenase/ 5-monooxgenase Ywhag 3.27 activation protein, gamma polypeptide NM_019180 Mast protease 6 Mcpt6 3.25

NM_012893 , gamma 2 Actg2 3.18 NM_133597 Cholinergic receptor, nicotinic, beta polypeptide 3 Chrnb3 3.17 NM_012735 2 Hk2 3.16 0.33 AA892567 Arcn1 3.12 BE107464 ARP2 actin-related protein 2 homolog (yeast) (predicted) Actr2 3.12 X65747 Guanine nucleotide binding protein, alpha transducing 3 Gnat3 3.10 0.46 NM_012963 High mobility group box 1 Hmgb1 3.08 NM_017344 kinase 3 alpha Gsk3a 3.08 NM_053459 RAB27B, member RAS oncogene family Rab27b 3.05 NM_012610 Nerve receptor (TNFR superfamily, Ngfr 3.05 member 16) NM_053868 1 Nlgn1 3.00

AI045600 Translocating chain-associating Tram1 2.98 AF378093 , voltage-gated, type III, beta Scn3b 2.97 NM_021855 Cone-rod protein Crx 2.97 NM_013189 Guanine nucleotide binding protein, alpha z subunit Gnaz 2.96 NM_019343 Regulator of G-protein signaling 7 Rgs7 2.95 U77697 /endothelial molecule Pecam 2.95 NM_130822 -independent alpha-latrotoxin receptor homolog Lphn3 2.95 3 NM_057115 Protein tyrosine , non-receptor type 12 Ptpn12 2.94

NM_013177 Glutamate oxaloacetate 2 Got2 2.93 NM_017041 3, catalytic subunit, alpha isoform Ppp3ca 2.91 NM_019204 Beta-site APP cleaving Bace 2.90 NM_016990 Adducin 1 (alpha) Add1 2.88 U70050 Jagged 2 Jag2 2.84 BF555949 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Hmgcr 2.84 NM_017140 receptor D3 Drd3 2.81 NM_013155 Very low density lipoprotein receptor Vldlr 2.80 AW919190 1, alpha Tpm1 2.77 NM_017049 Solute carrier family 4, member 3 Slc4a3 2.77 U54632 -conjugating enzyme E2I Ube2i 2.76 AF031879 , heavy polypeptide Nefh 2.76

2

Downloaded from iovs.arvojournals.org on 09/30/2021 AF087696 Membrane protein, palmitoylated 2 (MAGUK p55 Mpp2 2.76 subfamily member 2) AF030050 Replication factor C 1 Recc1 2.75

AF083329 Interleukin 12 receptor, beta 2 Il12rb2 2.75 AI599641 Bromodomain-containing 2 Brd2 2.75 NM_012504 ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1 2.74 NM_019283 Solute carrier family 3 (activators of dibasic and neutral Slc3a2 2.74 transport), member 2 NM_017198 (CDKN1A)-activated kinase 1 Pak1 2.72

NM_053818 Solute carrier family 6 ( transporter, Slc6a9 2.71 ), member 9 NM_053357 beta Catnb 2.70

NM_019326 Neurogenic differentiation 2 Neurod2 2.70 0.45 NM_022856 Ngfi-A binding protein 1 Nab1 2.68 M59786 , voltage-dependent, L type, alpha 1C Cacna1c 2.68 subunit AA892364 WW domain binding protein 11 (predicted) Wbp11 2.67

NM_019235 Gamma-glutamyltransferase-like activity 1 Ggtla1 2.63 NM_019315 Potassium intermediate/small conductance calcium- Kcnn3 2.63 activated channel, subfamily N, member 3 X64403 CCAAT/ binding protein (C/EBP), gamma Cebpg 2.62

BE109664 Casein kinase II, alpha 1 polypeptide Csnk2a1 2.60 NM_019358 38 Gp38 2.60 X76996 Granzyme B Gzmb 2.60 X69523 Retinol binding protein 3 Rbp3 2.59 NM_053554 Phosphatidylinositol binding assembly protein Picalm 2.59 BF281741 Glioma tumor suppressor candidate region 2 LOC2926 2.58 24 NM_030843 binding protein 5 (tomosyn) Stxbp5 2.58 NM_017303 Potassium voltage-gated channel, -related Kcnab1 2.57 subfamily, beta member 1 M90661 receptor-related receptor Insrr 2.57

NM_021592 and neural crest derivatives expressed transcript 1 Hand1 2.56 NM_022498 , catalytic subunit, gamma isoform Ppp1cc 2.54 AJ011607 DNA , p58 subunit Prim2 2.53 BF412073 T-cell lymphoma invasion and 1 (predicted) Tiam1 2.53 NM_021693 SNF1-like kinase Snf1lk 2.53 AA944176 Leucyl-tRNA synthetase (predicted) Lars 2.52 NM_021869 Syntaxin 7 Stx7 2.50 AB022209 Heterogeneous nuclear ribonucleoprotein F Hnrpf 2.49 NM_031514 Jak2 2.48 NM_019159 II Syn2 2.48 BE109242 Kirsten rat sarcoma viral oncogene homologue 2 (active) Kras2 2.47 NM_031070 Nel-like 2 homolog (chicken) Nell2 2.46 NM_021576 5 Nt5 2.46

3

Downloaded from iovs.arvojournals.org on 09/30/2021 AW914809 Germ cell-less protein Gcl 2.46 AW531901 Guanine nucleotide binding protein, alpha q polypeptide Gnaq 2.45 NM_017038 Protein phosphatase 1A, magnesium dependent, alpha Ppm1a 2.45 isoform NM_021766 receptor membrane component 1 Pgrmc1 2.45

J03819 receptor beta Thrb 2.43 AJ132846 Sodium-dependent neutral Slc1a5 2.43 ASCT2 NM_031119 Sjogren syndrome antigen B Ssb 2.43

AI105205 CDW92 antigen Cdw92 2.43 AI409899 Solute carrier family 20, member 2 Slc20a2 2.42 NM_080904 ADP-ribosylation factor 3 Arf3 2.41 NM_012764 GATA binding protein 1 Gata1 2.41 NM_013013 Prosaposin Psap 2.41 0.49 AI575254 Sideroflexin 5 Sfxn5 2.40 NM_012744 Pc 2.40 NM_021264 Ribosomal protein L35a Rpl35a 2.39 NM_057153 Oxr1 2.38 BF289092 Chloride intracellular channel 4 Clic4 2.38 NM_013090 Vesicle-associated membrane protein 1 Vamp1 2.38 BE108905 Nucleosome assembly protein 1-like 1 Nap1l1 2.37 NM_053989 dd5 2.36 NM_017325 Runt related transcription factor 1 Runx1 2.36 NM_053431 Quiescin Q6 Qscn6 2.33 NM_017153 Ribosomal protein S3a Rps3a 2.32 Y13972 MHC class I-like sequence Hlals 2.32 NM_031007 Adenylate cyclase 2 Adcy2 2.31 NM_013060 Inhibitor of DNA binding 2, dominant negative helix-loop- Id2 2.31 helix protein AF313411 Putative small membrane protein NID67 Nid67 2.31

NM_013151 Plasminogen activator, tissue Plat 2.30 NM_031777 Upstream transcription factor 1 Usf1 2.30 M69138 Nuclease sensitive element binding protein 1 Nsep1 2.30 NM_021694 Rho guanine nucleotide exchange factor (GEF) 1 Arhgef1 2.29 NM_031814 -coupled receptor kinase interactor 1 Git1 2.29 NM_013043 Tgfb1i4 2.29 AF021923 Solute carrier family 24 (sodium/potassium/calcium Slc24a2 2.28 exchanger), member 2 NM_031788 RE1-silencing transcription factor Rest 2.27

NM_138505 Adrenergic receptor, alpha 2b Adra2b 2.27 M83676 RAB12, member RAS oncogene family Rab12 2.26 NM_017090 1, soluble, alpha 3 Gucy1a3 2.26 AW435429 G-protein signalling modulator 1 (AGS3-like, C. elegans) Gpsm1 2.26 NM_019280 protein alpha 5 Gja5 2.26

NM_053592 Deoxyuridine Dutp 2.25

4

Downloaded from iovs.arvojournals.org on 09/30/2021 BF525153 G1 to S phase 1 Gspt1 2.25 NM_017028 Mx2 2.25 NM_031977 Rous sarcoma oncogene Src 2.25 NM_053335 C-terminal binding protein 2 Ctbp2 2.25 NM_057114 Peroxiredoxin 1 Prdx1 2.24 NM_053471 Sema domain, transmembrane domain (TM), and Sema6b 2.24 cytoplasmic domain, () 6B NM_133419 Dyskeratosis congenita 1, dyskerin Dkc1 2.23

Y17326 Cleavage and specific factor 4 Cpsf4 2.23 NM_031684 Solute carrier family 29 (nucleoside transporters), Slc29a1 2.22 0.44 member 1 AI411375 V-ets erythroblastosis virus E26 oncogene homolog 2 Ets2 2.21 (avian) AI180349 Solute carrier organic anion transporter family, member Slco4a1 2.20 4a1 AF065161 Cytokine inducible SH2-containing protein Cish 2.20

BF284242 Adaptor-related 1, gamma 1 subunit Ap1g1 2.20 U17565 Mini maintenance deficient 6 (S. cerevisiae) Mcmd6 2.19 AA800210 Casein kinase II, alpha 1 polypeptide Csnk2a1 2.18

BF412673 Beta-site APP cleaving enzyme Bace 2.17 AF027984 Calcium channel, voltage-dependent, T type, alpha 1G Cacna1g 2.17 subunit NM_021669 precursor Ghrl 2.16

AF050183 Synaptic Ras GTPase activating protein 1 homolog (rat) Syngap1 2.16 NM_017152 Ribosomal protein S17 Rps17 2.16

NM_012923 G1 Ccng1 2.16 NM_012940 P450, family 1, subfamily b, polypeptide 1 Cyp1b1 2.16 BG671511 Chaperonin containing TCP1, subunit 2 (beta) Cct2 2.15 NM_017220 6-pyruvoyl-tetrahydropterin synthase Pts 2.15 M61726 Upstream binding transcription factor, RNA I Ubtf 2.15 BE099732 Protein tyrosine phosphatase, receptor type, G Ptprg 2.15

NM_133304 Hephaestin Heph 2.14 NM_031020 activated 14 Mapk14 2.14 NM_012700 Syntaxin 1B2 Stx1b2 2.13 NM_031030 Cyclin G associated kinase Gak 2.13 NM_017188 UNC-119 homolog (C. elegans) Unc119 2.13 BE113034 HesB protein Hbld2 2.13 NM_012805 X receptor alpha Rxra 2.12 NM_053573 Olfactomedin 1 Olfm1 2.12 AA892770 Glutamate-cysteine ligase, catalytic subunit Gclc 2.11 AW144441 C-terminal binding protein 2 Ctbp2 2.11 NM_053297 , muscle Pkm2 2.11 NM_013022 Rho-associated coiled-coil forming kinase 2 Rock2 2.11 NM_012502 receptor Ar 2.10

5

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_057103 A kinase (PRKA) anchor protein (gravin) 12 Akap12 2.09 NM_017033 Phosphoglucomutase 1 Pgm1 2.09 X53858 Thyroid transcription factor 1 Titf1 2.09 NM_031568 7 Clcn7 2.09 BF288776 -associated 1A/1B chain 3 Map1lc3b 2.08 NM_017101 Peptidylprolyl A Ppia 2.08 NM_032080 Glycogen synthase kinase 3 beta Gsk3b 2.08 AA946474 Calpastatin Cast 2.08 AF099093 Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. Ube2g1 2.07 elegans) NM_031006 Adenosine deaminase, RNA-specific Adar 2.07

AW434007 Eukaryotic 1 gamma Eef1g 2.07 NM_012529 , Ckb 2.07 BF419628 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 Ddx1 2.06 NM_013199 2 Dnm2 2.06 Y14933 One cut domain, family member 1 Onecut1 2.06 NM_031134 Thyroid alpha Thra 2.06 NM_012516 binding protein, alpha C4bpa 2.06 NM_017010 , ionotropic, N-methyl D-aspartate 1 Grin1 2.06 NM_078622 cytidylyltransferase 1, choline, alpha isoform Pcyt1a 2.06 AI599479 Optineurin Optn 2.04

NM_031652 Potassium voltage gated channel, shaker related Kcnab3 2.04 subfamily, beta member 3 AB018253 Two pore channel 1 Tpcn1 2.03

AA799614 (silent mating type information regulation 2 Sirt2 2.02 homolog) 2 (S. cerevisiae) NM_017215 Solute carrier family 1 (glial high affinity glutamate Slc1a2 2.02 transporter), member 2 AJ011299 Interleukin 5 Il5 2.02

AI598988 Calcium/-dependent protein kinase II gamma Camk2g 2.01 NM_031614 Thioredoxin reductase 1 Txnrd1 2.01 NM_013100 E receptor 1 Ptger1 2.01 AA817722 Catenin (cadherin-associated protein), alpha 1, 102kDa Catna1 2.01 NM_021765 protein complex, subunit beta 2 (beta prime) Copb2 2.01 BF408792 Protein phosphatase 2a, catalytic subunit, alpha isoform Ppp2ca 2.01 NM_053740 Rho guanine nucleotide exchange factor 7 Arhgef7 2.00

AI706451 RAB6B, member RAS oncogene family Rab6 2.00 NM_031133 Thpo 2.00 M30596 Malic enzyme 1 Me1 2.00 NM_021850 Bcl2-like 2 Bcl2l2 2.00 NM_019328 Nuclear receptor subfamily 4, group A, member 2 Nr4a2 1.99 NM_053739 Beclin 1 (coiled-coil, -like BCL2-interacting Becn1 1.99 protein) BF562701 Syntaxin binding protein 1 Stxbp1 1.99

6

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_031051 migration inhibitory factor Mif 1.98 NM_012875 Ribosomal protein L39 Rpl39 1.98 BF567631 1 Sulf1 1.98 D26178 Intestinal cell kinase Ick 1.97 NM_012615 Ornithine decarboxylase 1 Odc1 1.97 AF109393 Podocalyxin-like Podxl 1.97 NM_053662 Cyclin Ccnl1 1.97 NM_134432 Angiotensinogen Agt 1.97 AW530332 CASK-interacting protein CIP98 Cip98 1.96 NM_019257 Splicing factor, /-rich 5 Sfrs5 1.96 NM_031552 Adducin 3 (gamma) Add3 1.96 AA946011 Phosphatidylinositol-4-phosphate 5-kinase, type II, Pip5k2c 1.96 gamma NM_021856 Clock homolog (mouse) Clock 1.95

BE108192 G1 to S phase transition 1 Gspt1 1.95 AF142499 Tumor necrosis factor receptor superfamily, member 1b Tnfrsf1b 1.95 NM_020090 Solute carrier family 24 (sodium/potassium/calcium Slc24a1 1.95 exchanger), member 1 NM_031351 Attractin Atrn 1.94

NM_021772 Cyclin-dependent kinase-like 3 Cdkl3 1.94 M81766 Rxrb 1.94 NM_017209 Nuclear receptor binding factor 1 Nrbf1 1.94 NM_022217 1 Amph1 1.94 NM_013135 RAS p21 protein activator 1 Rasa1 1.94 NM_053996 Solute carrier family 6 (neurotransmitter transporter, L- Slc6a7 1.94 ), member 7 NM_134353 Poly(A) binding protein, cytoplasmic 1 Pabpc1 1.93

NM_080689 Dynamin 1 Dnm1 1.93 NM_033096 Protein phosphatase 1B, magnesium dependent, beta Ppm1b 1.93 isoform NM_080481 ATP synthase, H+ transporting, mitochondrial F0 Atp5i 1.93 complex, subunit e X83094 Heat shock transcription factor 1 Hsf1 1.93

NM_053330 Ribosomal protein L21 Rpl21 1.93 AA943135 Mitofusin 1 Mfn1 1.92 AI230596 alpha 1 ( alpha 5) Kpna1 1.92 BF387153 Protein phospatase 3, regulatory subunit B, alpha Ppp3r1 1.92 isoform,type 1 NM_053920 interactor 10 Trip10 1.92

NM_053417 bound protein 2-associated Gab2 1.91 protein 2 NM_053609 HLA-B-associated transcript 3 Bat3 1.91

AB070355 family member 1B Kif1b 1.91 NM_022234 Amiloride-sensitive cation channel 4, pituitary Accn4 1.91

7

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_053763 Cytochrome P450, family 27, subfamily b, polypeptide 1 Cyp27b1 1.91 AB020615 , lambda Pkcl 1.91

NM_031597 Potassium voltage-gated channel, subfamily Q, member Kcnq3 1.90 3 NM_012570 Glutamate 1 Glud1 1.90

U51013 Centaurin, alpha 1 Centa1 1.90 NM_130423 Gamma-glutamyltransferase-like 3 Ggtl3 1.89 NM_031146 Actin related protein 2/3 complex, subunit 1A Arpc1a 1.89 NM_053685 Hyperpolarization-activated cyclic nucleotide-gated Hcn3 1.89 3 BE109704 Cysteine string protein Dnajc5 1.89

BG664778 Ras-related C3 botulinum toxin 1 Rac1 1.89 AA819832 Period homolog 1 (Drosophila) Per1 1.89 NM_053945 Regulating synaptic membrane exocytosis 2 Rims2 1.88 NM_017039 Protein phosphatase 2a, catalytic subunit, alpha isoform Ppp2ca 1.88 NM_080778 Nuclear receptor subfamily 2, group F, member 2 Nr2f2 1.87

AF095585 PDZ and LIM domain 7 Pdlim7 1.87 AB023634 Protein phosphatase 1F (PP2C domain containing) Ppm1f 1.87 NM_012750 Glial cell line derived neurotrophic factor family receptor Gfra2 1.87 alpha 2 NM_012721 P2X-like 1, P2rxl1 1.87

NM_053594 Protein tyrosine phosphatase, receptor type, R Ptprr 1.87 NM_017180 Pleckstrin homology-like domain, family A, member 1 Phlda1 1.87 U91679 FEV (ETS oncogene family) Fev 1.86 AA819716 1 Synj1 1.86 NM_017192 Endothelial differentiation, sphingolipid G-protein-coupled Edg5 1.86 receptor, 5 NM_053438 Ring finger protein 103 Rnf103 1.86

NM_013181 Protein kinase, cAMP dependent regulatory, type I, alpha Prkar1a 1.86 J03959 Urate oxidase Uox 1.86

NM_021769 family 1D, member 1 Sult1d1 1.85 BG671816 ELOVL family member 5, elongation of long chain fatty Elovl5 1.85 acids (yeast) AI411979 Carnitine acetyltransferase Crat 1.85

NM_031759 N-acetylated alpha-linked acidic dipeptidase-like 1 Naaladl1 1.85 U21871 of outer mitochondrial membrane 20 Tomm20 1.84 homolog (yeast) NM_013080 Protein tyrosine phosphatase, receptor-type, Z Ptprz1 1.84 polypeptide 1 NM_031641 Sulfotransferase family 4A, member 1 Sult4a1 1.84

AF277899 XPA binding protein 2 Xab2 1.84 M34052 Potassium voltage gated channel, Shaw-related Kcnc2 1.84

8

Downloaded from iovs.arvojournals.org on 09/30/2021 subfamily, member 2 AB012233 /C Nfic 1.83

U38376 A2, group IVA (cytosolic, calcium- Pla2g4a 1.83 dependent) AA899704 16 Vps16 1.83

AI070137 -specific amine oxidase Aoc3 1.83 NM_019353 Thyroid peroxidase Tpo 1.83 NM_031715 , muscle Pfkm 1.83 NM_019346 Solute carrier family 14 ( transporter), member 1 Slc14a1 1.83 (Kidd blood group) NM_012611 Nitric oxide synthase 2, inducible Nos2 1.82 0.49

X89962 RNA-binding protein pippin Pippin 1.82 NM_012507 ATPase, Na+/K+ transporting, beta 2 polypeptide Atp1b2 1.82 BF419134 DMT1-associated protein Acbd3 1.82 AA818128 F-box only protein 11 Fbxo11 1.82 NM_017279 (prosome, macropain) subunit, alpha type 2 Psma2 1.82 0.46 NM_133574 Aminopeptidase Vp165 Lnpep 1.82

AF148210 RAB6B, member RAS oncogene family Rab6 1.82 BE107358 Pumilio 2 (Drosophila) (predicted) Pum2 1.81 AI073125 Glutathione peroxidase 4 Gpx4 1.80 NM_053523 Homocysteine-inducible, stress- Herpud1 1.80 inducible, ubiquitin-like domain member 1 NM_019290 B-cell translocation gene 3 Btg3 1.80

NM_022232 Protein kinase inhibitor p58 Dnajc3 1.80 NM_031703 3 Aqp3 1.80 NM_017361 54 Nup54 1.79 AA900046 General transcription factor II I repeat domain-containing Gtf2ird1 1.79 1 L08812 Transcription factor EC Tfec 1.79

NM_017190 -associated glycoprotein Mag 1.79 Y09111 A disintegrin and metallopeptidase domain 6 Adam6 1.79 NM_057107 Acyl-CoA synthetase long-chain family member 3 Acsl3 1.79 X78689 EphA5 Epha5 1.79 NM_017228 Dentatorubral pallidoluysian atrophy Drpla 1.78 AA866477 subunit VIIb Cox7b 1.78 NM_012879 Solute carrier family 2 (facilitated ), Slc2a2 1.78 member 2 NM_017275 upregulated non-ubiquitously expressed CaM Pnck 1.78 kinase NM_031543 Cytochrome P450, family 2, subfamily e, polypeptide 1 Cyp2e1 1.78

NM_012924 CD44 antigen Cd44 1.78 NM_012668 Tyrosine aminotransferase Tat 1.78 NM_012974 , beta 2 Lamb2 1.78

9

Downloaded from iovs.arvojournals.org on 09/30/2021 AF347936 receptor, alpha chain 1 Il11ra1 1.78 NM_130736 Solute carrier family 21, member 1 Slc21a1 1.78 NM_013134 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Hmgcr 1.78 NM_031054 Matrix metallopeptidase 2 Mmp2 1.77 NM_032083 (chimaerin) 1 Chn1 1.77 AF295405 Secretory carrier membrane protein 2 Scamp2 1.77 NM_019302 V-crk sarcoma virus CT10 oncogene homolog (avian) Crk 1.77 NM_019133 Syn1 1.76 NM_031026 , cytoplasmic, light intermediate polypeptide 2 Dncli2 1.76 AF241231 Tumor necrosis factor receptor superfamily, member 5 Tnfrsf5 1.76 (predicted) BE102100 Frequenin homolog (Drosophila) Freq 1.76

NM_022404 G protein beta subunit-like Gbl 1.76 NM_017148 Cysteine and glycine-rich protein 1 Csrp1 1.76 NM_012753 Cytochrome P450, family 17, subfamily a, polypeptide 1 Cyp17a1 1.76 NM_017284 Proteasome (prosome, macropain) subunit, beta type 2 Psmb2 1.76

NM_021740 Prothymosin alpha Ptma 1.76 NM_057210 glycoprotein 2a Sv2a 1.76 NM_017255 Purinergic receptor P2Y, G-protein coupled 2 P2ry2 1.76 NM_020098 Piccolo (presynaptic cytomatrix protein) Pclo 1.76 0.46 NM_019364 Sec1 family domain containing 1 Scfd1 1.76 NM_031740 B4galt6 1.75 AA848536 2 (thioltransferase) (predicted) Glrx2 1.75 NM_053867 Tumor protein, translationally-controlled 1 Tpt1 1.75 NM_031617 , epsilon Csnk1e 1.75 NM_017292 Gamma-aminobutyric acid A receptor, rho 2 Gabrr2 1.74 NM_031143 zeta Dgkz 1.74 BE096021 Jun D proto-oncogene Jund 1.74 NM_031522 1 Neu1 1.74 AW918990 RAB21, member RAS oncogene family Rab21 1.74 U76717 PG10.2 protein Pg10.2 1.74 NM_022865 Gephyrin Gphn 1.73 U04933 Solute carrier family 8 (sodium/calcium exchanger), Slc8a1 1.73 member 1 BE110695 Activating transcription factor 1 (predicted) Atf1 1.73

NM_012639 Murine leukemia viral (v-raf-1) oncogene homolog 1 Raf1 1.73 (3611-MSV) AF032925 Vascular endothelial growth factor B Vegfb 1.73

NM_013169 CD3 antigen delta polypeptide Cd3d 1.72 NM_012555 V-ets erythroblastosis virus E26 oncogene homolog 1 Ets1 1.72 (avian) NM_017224 Solute carrier family 22 (organic anion transporter), Slc22a6 1.72 member 6 AJ238278 Exportin 1, CRM1 homolog (yeast) Xpo1 1.72

NM_017251 Gap junction membrane channel protein beta 1 Gjb1 1.72

10

Downloaded from iovs.arvojournals.org on 09/30/2021 M60616 Matrix metallopeptidase 13 Mmp13 1.72 NM_017163 Solute carrier family 6 (neurotransmitter transporter), Slc6a18 1.72 member 18 NM_024378 Glutamate receptor, ionotropic, delta 1 Grid1 1.71

AI172165 Peroxisomal protein Fndc5 1.71 AA848305 RAS related protein 1b Rap1b 1.71 AW435349 CCAAT/enhancer binding protein (C/EBP), gamma Cebpg 1.71 AI231827 ADP-ribosylation factor guanine nucleotide-exchange Arfgef2 1.70 factor 2 (-inhibited) AW913858 Myeloid differentiation primary response gene 88 Myd88 1.70

NM_017329 Surfactant, pulmonary-associated protein A1 Sftpa1 1.70 NM_017054 receptor Tbxa2r 1.70 NM_021751 Prominin 1 Prom1 1.69 AB000489 Solute carrier family 20 (phosphate transporter), member Slc20a1 1.69 1 AW144233 Alpha-N-acetylgalactosaminide alpha-2,6- Siat7b 1.69 II () NM_017066 Ptn 1.69

NM_017012 Glutamate receptor, metabotropic 5 Grm5 1.69 NM_053604 Alpha-1,6-mannosyl-glycoprotein 2-beta-N- Mgat2 1.69 acetylglucosaminyltransferase NM_013219 Ca<2+-dependent activator protein for secretion Cadps 1.69

NM_012612 Natriuretic precursor type A Nppa 1.69 NM_023104 Acetoacetyl-CoA synthetase Aacs 1.69 NM_134392 Spermatogenesis associated 6 Spata6 1.69 NM_019218 Neurogenic differentiation 1 Neurod1 1.68 NM_013141 Peroxisome proliferator activated receptor delta Ppard 1.68 NM_012679 Clu 1.68 NM_019387 HGF-regulated tyrosine kinase substrate Hgs 1.68 M92075 Glutamate receptor, metabotropic 2 Grm2 1.67 X56228 Thiosulfate sulfurtransferase Tst 1.67 NM_052808 Parotid secretory protein Psp 1.67 NM_012595 B Ldhb 1.67 AF204873 Wingless-type MMTV integration site family, member 2B Wnt2b 1.67 AJ011608 DNA primase, p49 subunit Prim1 1.67

BE109016 SRY-box containing gene 11 Sox11 1.67 U67139 Discs, large (Drosophila) homolog-associated protein 3 Dlgap3 1.67 NM_053375 Hyperpolarization-activated, cyclic nucleotide-gated Hcn1 1.67 potassium channel 1 NM_053795 Kinase D-interacting substance 220 Kidins220 1.67

NM_012773 Akap11 1.67 AF039203 Corticotropin releasing hormone receptor 1 Crhr1 1.67 NM_053506 H3 Hrh3 1.67 X13817 Calmodulin 3 Calm3 1.67

11

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_133418 Solute carrier family 25 (; Slc25a10 1.66 dicarboxylate transporter), member 10 NM_021748 N-ethylmaleimide sensitive Nsf 1.66

NM_031527 Protein phosphatase 1, catalytic subunit, alpha isoform Ppp1ca 1.66 M83678 RAB13, member RAS oncogene family Rab13 1.66 AF205438 Tribbles homolog 1 (Drosophila) Trib1 1.66 NM_053840 Gamma-glutamyltransferase 1 Ggt1 1.65 BE108396 Rcd1 (required for cell differentiation) homolog 1 (S. Rqcd1 1.65 pombe) (predicted) AI169224 Thioredoxin domain containing 4 (endoplasmic reticulum) Txndc4 1.65 (predicted) NM_031841 Stearoyl-Coenzyme A desaturase 2 Scd2 1.65

AF184920 Glial cell line derived neurotrophic factor family receptor Gfra3 1.65 alpha 3 AA925330 Glial cell line derived neurotrophic factor family receptor Gfra3 1.64 alpha 3 NM_012746 Proprotein convertase subtilisin/kexin type 2 Pcsk2 1.64

L06821 Nucleoporin 153kD Nup153 1.64 NM_017289 Gamma-aminobutyric acid A receptor, delta Gabrd 1.64 NM_012633 1 Prph1 1.64 NM_031737 NK6 transcription factor related, 1 (Drosophila) Nkx6-1 1.64 NM_013037 Interleukin 1 receptor-like 1 Il1rl1 1.63 NM_053288 Orosomucoid 1 Orm1 1.63 NM_017189 Asialoglycoprotein receptor 2 Asgr2 1.63 NM_017256 Transforming growth factor, beta receptor 3 Tgfbr3 1.63 AI229630 Translocating chain-associating membrane protein Tram1 1.62 AA943100 Chloride channel 7 Clcn7 1.62 NM_016991 Adrenergic receptor, alpha 1b Adra1b 1.62 NM_012682 1 Ucp1 1.62 J05499 2 (, mitochondrial) Gls2 1.62 AI412015 M1 Rrm1 1.62 NM_012569 Glutaminase Gls 1.62 AA799791 Serine/threonine kinase 25 (STE20 homolog, yeast) Stk25 1.61 NM_012758 tyrosine kinase Syk 1.61 NM_021863 Heat shock protein 2 Hspa2 1.61 BF398424 B7-H3 B7h3 1.61 NM_017246 Mitogen activated protein kinase kinase 5 Map2k5 1.61 AF038043 (brush-border membrane glycoprotein) Treh 1.61 AF046886 Axl Axl 1.61 NM_012685 Vasoactive intestinal peptide receptor 1 Vipr1 1.61 AA850531 Discs, large (Drosophila) homolog-associated protein 1 Dlgap1 1.61 NM_031537 Slc11a1 1.61 X79991 Cytochrome P450, 3a18 Cyp3a18 1.60 X79328 Thioredoxin domain containing 7 Txndc7 1.60 AW435440 Nischarin (predicted) Nisch 1.60 AA799709 SNAP-associated protein Snapap 1.60 NM_012743 Forkhead box A2 Foxa2 1.60

12

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_031695 Sialyltransferase 4B (beta-galactoside alpha-2,3- Siat4b 1.60 0.45 sialyltransferase) J05181 Glutamate-cysteine ligase, catalytic subunit Gclc 1.60

NM_031808 Calpain 6 Capn6 1.59 NM_021775 Endothelial differentiation, sphingolipid G-protein-coupled Edg8 1.59 receptor, 8 NM_012747 Signal transducer and activator of transcription 3 Stat3 1.59

NM_080886 Sterol-C4-methyl oxidase-like Sc4mol 1.59 AA799784 RAB6B, member RAS oncogene family Rab6 1.59 NM_024486 Activin A receptor, type 1 Acvr1 1.59 NM_031694 2 Hsf2 1.59 NM_057185 Folh1 1.59 AF107723 G-protein signalling modulator 1 (AGS3-like, C. elegans) Gpsm1 1.59 NM_053866 , activating protein Plaa 1.58

U56859 Hspg2 1.58 NM_019163 1 Psen1 1.58 NM_019156 Vtn 1.58 AB017544 Peroxisomal biogenesis factor 14 Pex14 1.58 NM_017281 Proteasome (prosome, macropain) subunit, alpha type 4 Psma4 1.58 AF189709 , type XVIII, alpha 1 Col18a1 1.58

NM_133579 Zinc finger protein 22 (KOX 15) Znf22 1.58 NM_013165 B receptor Cckbr 1.58 AI233194 Solute carrier family 30 (zinc transporter), member 1 Slc30a1 1.57 AF237778 Calcium/calmodulin-dependent protein kinase II alpha Camk2a 1.57 subunit AF322224 Nuclear receptor coactivator 3 Ncoa3 1.57

BE096652 antigen 6 complex, locus G6C Ly6g6c 1.57 AA892250 Lysyl-tRNA synthetase Kars 1.57 NM_017155 Adora1 1.56 NM_022692 RAB5A, member RAS oncogene family Rab5a 1.56 AF139830 Insulin-like growth factor binding protein 5 Igfbp5 1.56 AF062594 Nucleosome assembly protein 1-like 1 Nap1l1 1.56 NM_012745 Killer cell lectin-like receptor, subfamily D, member 1 Klrd1 1.56 BE112575 Ubiquitin specific protease 14 (predicted) Usp14 1.56 NM_053979 ADP-ribosylation factor-like 5 Arl5 1.56 NM_017043 Prostaglandin-endoperoxide synthase 1 Ptgs1 1.56 AW915499 Vacuole 14 protein (S. cerevisiae) Vac14 1.56 AF367467 Ratsg2 Ratsg2 1.56 NM_053401 receptor (TNFRSF16) associated Ngfrap1 1.56 protein 1 L14776 Cathepsin J Ctsq 1.55

BF283772 V- reticuloendotheliosis viral oncogene homolog A Rela 1.55 (avian)

13

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_019279 Proprotein convertase subtilisin/kexin type 1 inhibitor Pcsk1n 1.55

AW915160 Casein kinase 1, epsilon Csnk1e 1.55 U49055 RNA binding motif protein 16 Rbm16 1.55 NM_012704 Prostaglandin E receptor 3 (subtype EP3) Ptger3 1.55 AA800490 CD36 antigen (collagen type I receptor, thrombospondin Scarb2 1.55 receptor)-like 2 AA964535 Parvin, alpha Parva 1.55

NM_053928 Ubiquitin-conjugating enzyme E2N (homologous to yeast Ube2n 1.55 UBC13) NM_019362 Serine/threonine kinase 39, STE20/SPS1 homolog Stk39 1.54 (yeast) BF417442 induced gene 1 Hig1 1.54

NM_019371 EGL nine homolog 3 (C. elegans) Egln3 1.54 NM_017089 B1 Efnb1 1.54 NM_053403 Growth factor receptor bound protein 7 Grb7 1.54 NM_031855 Ketohexokinase Khk 1.54 NM_133294 Hemogen Hemgn 1.54 NM_031823 Wolfram syndrome 1 Wfs1 1.54 X51707 Rps19 1.54 X99723 SWI/SNF related, matrix associated, actin dependent Smarca4 1.54 regulator of , subfamily a, member 4 NM_013167 Uncoupling protein 3 Ucp3 1.53

NM_053909 Neurofascin Nfasc 1.53 NM_022848 ATPase, Na+/K+ transporting, alpha 4 polypeptide Atp1a4 1.53 NM_017288 Sodium channel, voltage-gated, type I, beta polypeptide Scn1b 1.53 NM_133562 Phosphatidylinositol (4,5) bisphosphate 5-phosphatase, Pib5pa 1.53 A NM_031984 1 Calb1 1.53

NM_053856 Secretogranin III Scg3 1.52 BE113110 Adaptor protein complex AP-2, alpha 2 subunit Ap2a2 1.52 NM_021688 Potassium channel, subfamily K, member 1 Kcnk1 1.52 NM_053346 Neuritin Nrn1 1.52 NM_017112 Hepsin Hpn 1.52 NM_134334 Cathepsin D Ctsd 1.52 NM_053929 Solute carrier family 7 (cationic amino acid transporter, Slc7a9 1.51 y+ system), member 9 NM_031343 Solute carrier family 6 (neurotransmitter transporter, Slc6a2 1.51 noradrenalin), member 2 AI171785 Gamma-aminobutyric acid (GABA) B receptor 1 Gabbr1 1.51

NM_031542 Breast 2 Brca2 1.51 NM_053962 Serine dehydratase Sds 1.51 BE100607 Phosphatidylinositol membrane-associated (predicted) Pitpnm1 1.51 NM_031688 , gamma Sncg 1.51 NM_022206 Unc-5 homolog A (C. elegans) Unc5a 1.51

14

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_012582 Haptoglobin Hp 1.51 NM_053580 Solute carrier family 27 (fatty acid transporter), member 1 Slc27a1 1.51 J02582 Apoe 1.51

NM_053912 Pleckstrin homology, Sec7 and coiled-coil domains 3 Pscd3 1.50 NM_031800 Death domain-containing Dedd 1.50 BE107674 Kinesin family member 5A Kif5a 1.50 BF550453 Lin-10 protein homolog (C. elegans) Lin10 1.50 NM_022260 Casp7 1.50 BE103543 Replication factor C 1 Recc1 1.50 NM_017267 Translocator of inner mitochondrial membrane 44 Timm44 1.50 NM_022609 Galactoside beta-1,3-glucuronyltransferase B3gat2 1.50 NM_053306 P21 (CDKN1A)-activated kinase 2 Pak2 1.50 NM_013137 Discoidin domain receptor family, member 1 Ddr1 1.50 NM_012548 1 Edn1 1.50 NM_031036 Guanine nucleotide binding protein, alpha q polypeptide Gnaq 1.50 BE103518 Plexin A3 Plxna3 1.50 NM_133541 General transcription factor III C 1 Gtf3c1 1.50 NM_031793 Peptidylprolyl isomerase G Ppig 1.49 NM_012935 Crystallin, alpha B Cryab 1.49 NM_017032 Phosphodiesterase 4D Pde4d 1.49 NM_021764 Protein kinase C-binding protein Beta15 Pkcbpb15 1.49 NM_134414 Rsec5 protein Sec5l1 1.49 M22756 NADH dehydrogenase (ubiquinone) flavoprotein 2 Ndufv2 1.49 M29295 Small nuclear ribonucleoprotein polypeptides B and B1 Snrpb 1.49 AI454612 4 Syt4 1.49 NM_013055 Mitogen activated protein kinase kinase kinase 12 Map3k12 1.49 NM_031079 Phosphodiesterase 2A, cGMP-stimulated Pde2a 1.49 NM_130829 Paralemmin Palm 1.48 AA894099 Vacuolar protein sorting 4a (yeast) Vps4a 1.48 NM_031523 Nerve growth factor, gamma Ngfg 1.48 NM_031003 4-aminobutyrate aminotransferase Abat 1.48 NM_019186 ADP-ribosylation factor-like 4 Arl4 1.48 NM_013049 Tumor necrosis factor receptor superfamily, member 4 Tnfrsf4 1.48 NM_024351 Heat shock protein 8 Hspa8 1.48 NM_019313 Potassium intermediate/small conductance calcium- Kcnn1 1.48 activated channel, subfamily N, member 1 NM_053959 Bridging integrator 1 Bin1 1.48

AF268593 alpha M Itgam 1.47 AI013500 Coated vesicle membrane protein Rnp24 1.47 NM_053683 NADPH oxidase 1 Nox1 1.47 NM_138538 Testicular dynamin Dnm3 1.47 NM_031331 Proteasome (prosome, macropain) 26S subunit, non- Psmd4 1.47 ATPase, 4 AW141867 Plexin A3 Plxna3 1.47

U49057 CTD-binding SR-like protein rA9 LOC2459 1.47 25 NM_022632 Slit2 1.47

15

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_012634 Phosphoribosyl synthetase 2 Prps2 1.47 AJ003065 Potassium inwardly-rectifying channel, subfamily J, Kcnj14 1.47 member 14 NM_019297 Cholinergic receptor, nicotinic, beta polypeptide 2 Chrnb2 1.46 (neuronal) AW917574 Tumor necrosis factor superfamily member 12 Tnfsf12 1.46

NM_031622 Mitogen-activated protein kinase 6 Mapk6 1.46 NM_019234 Dynein, cytoplasmic, intermediate chain 1 Dncic1 1.46 NM_017221 Sonic hedgehog homolog (Drosophila) Shh 1.46 AF044201 Fas apoptotic inhibitory molecule 2 Faim2 1.45 NM_021770 transcription factor 1 Olig1 1.45 NM_019348 receptor 2 Sstr2 1.45 NM_133283 Mitogen activated protein kinase kinase 2 Map2k2 1.45 L15453 Calcium channel, voltage-dependent, L type, alpha 1E Cacna1e 1.45 subunit NM_020471 Insulin related protein 2 Isl2 1.45

NM_080690 Cask-interacting protein 1 Caskin1 1.45 M69056 , CAAX box, beta Fntb 1.45 NM_031047 Junction Jup 1.45 NM_017008 Glyceraldehyde-3-phosphate dehydrogenase Gapd 1.45 NM_024485 Cholinergic receptor, nicotinic, alpha polypeptide 1 Chrna1 1.45 (muscle) NM_032084 Chimerin (chimaerin) 2 Chn2 1.44

D13341 Mitogen activated protein kinase kinase 1 Map2k1 1.44 NM_134417 Inositol polyphosphate multikinase Impk 1.44 NM_031634 Mediterranean fever Mefv 1.44 BF563467 synthetase 1 Glul 1.44 BF397933 Inositol hexaphosphate kinase 2 Ihpk2 1.44 NM_012576 Nuclear receptor subfamily 3, group C, member 1 Nr3c1 1.44 BE329415 Vaccinia related kinase 3 Vrk3 1.44 AW526756 Cysteine string protein Dnajc5 1.44 NM_012505 ATPase, Na+/K+ transporting, alpha 2 polypeptide Atp1a2 1.44 NM_080480 Phosphatidylinositol-4-phosphate 5-kinase, type II, Pip5k2c 1.44 gamma AA858930 Phosphodiesterase 4B Pde4b 1.43

NM_021662 Polymerase (DNA directed), delta 1, catalytic subunit Pold1 1.43 NM_021678 CaM-KII inhibitory protein LOC5931 1.43 4 NM_017035 , delta 1 Plcd1 1.43 AF293383 ATP-binding cassette, sub-family F (GCN20), member 1 Abcf1 1.43 NM_012811 Milk fat globule-EGF factor 8 protein Mfge8 1.43

X55969 Apolipoprotein B Apob 1.43 AW143077 Phosphatidylinositol-4-phosphate 5-kinase, type I, Pip5k1c 1.42 gamma (predicted)

16

Downloaded from iovs.arvojournals.org on 09/30/2021 M19044 ATP synthase, H+ transporting, mitochondrial F1 Atp5b 1.42 complex, beta polypeptide D50695 Proteasome (prosome, macropain) 26S subunit, ATPase, Psmc4 1.42 4 NM_012839 Cytochrome c, somatic Cycs 1.42

NM_053635 Suppression of tumorigenicity 14 St14 1.42 AI579555 Seryl-aminoacyl-tRNA synthetase 1 Sars1 1.42 AI232898 Dhfr 1.42 BE126380 N-myristoyltransferase 1 Nmt1 1.42 NM_017040 Protein phosphatase 2a, catalytic subunit, beta isoform Ppp2cb 1.42 J05266 ATP synthase, H+ transporting, mitochondrial F1 Atp5a1 1.42 complex, alpha subunit, isoform 1. NM_031822 Nuclear receptor coactivator 2 Ncoa2 1.42

M84416 Tyrosine 3-monooxygenase/tryptophan 5- Ywhae 1.41 monooxygenase activation protein, epsilon polypeptide AI175533 N-ethylmaleimide-sensitive factor attachment protein, Napg 1.41 gamma (predicted) NM_031575 Thymoma viral proto-oncogene 3 Akt3 1.41

NM_031238 SH3 domain protein 2 C1 Sh3gl3 1.41 NM_053509 Zona pellucida glycoprotein 1 Zp1 1.41 AW919036 Monoglyceride Mgll 1.41 AF110267 Golgi reassembly stacking protein 2 Gorasp2 1.41 AI176553 CCA2 protein Hsd3b7 1.40 BF394170 2 Jundp2 1.40 U72660 Ninjurin 1 Ninj1 1.40 NM_024149 ADP-ribosylation factor 5 Arf5 1.40 AW433973 Craniofacial development protein 1 Cfdp1 1.40 AF106657 Ubiquitin specific protease 15 Usp15 1.40 NM_053794 Protein kinase, deficient 1 Prkwnk1 1.40 NM_012999 Subtilisin - like endoprotease Pace4 1.40 NM_031787 Homeodomain interacting protein kinase 3 Hipk3 1.39 NM_032066 Translocase of inner mitochondrial membrane 23 Hsd17b12 1.39 homolog (yeast) BF551619 Glutamate receptor, ionotropic, NMDA2D Grin2d 1.39

AI172004 PR domain containing 4 Prdm4 1.39 NM_017147 Cofilin 1 Cfl1 1.39 AI105117 Upstream binding transcription factor, RNA polymerase I Ubtf 1.39 NM_017122 Hpca 1.39

AF059311 Nuclear receptor co- 1 Ncor1 1.39 BF404316 Casein kinase 1, gamma 1 Csnk1g1 1.39 Z48444 A disintegrin and metalloprotease domain 10 Adam10 1.39 X15030 Cytochrome c oxidase, subunit Va Cox5a 1.39 AI103916 Mitogen activated protein kinase 1 Mapk1 1.39 NM_017291 Gamma-aminobutyric acid A receptor, rho 1 Gabrr1 1.39 AF230638 Solute carrier family 14 (), member 2 Slc14a2 1.38

17

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_031599 2 alpha kinase 3 Eif2ak3 1.38 NM_031327 Cysteine rich protein 61 Cyr61 1.38 NM_031589 Solute carrier family 37 (-6-phosphate Slc37a4 1.38 transporter), member 4 BE105397 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) Bdh 1.38

NM_017017 Hgf 1.37

NM_012590 Inhibin alpha Inha 1.37 NM_012907 Apolipoprotein B editing complex 1 Apobec1 1.37 NM_053511 F-box only protein 2 Fbxo2 1.37 NM_013033 Solute carrier family 5 (sodium/glucose ), Slc5a1 1.37 member 1 NM_053336 Advanced glycosylation end -specific receptor Ager 1.37

NM_013074 Hypocretin () receptor 2 Hcrtr2 1.37 M81639 Stannin Snn 1.37 L26267 Nuclear factor of kappa light chain gene enhancer in B- Nfkb1 1.37 cells 1, p105 NM_012998 Prolyl 4-hydroxylase, beta polypeptide P4hb 1.37

BE110645 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- Galnt1 1.37 acetylgalactosaminyltransferase 1 AF012534 Trefoil factor 3 Tff3 1.36

NM_022298 , alpha 1 Tuba1 1.36 NM_013063 ADP-ribosyltransferase 1 Adprt 1.36 NM_080585 N-ethylmaleimide sensitive fusion protein attachment Napa 1.36 protein alpha NM_053849 Protein disulfide isomerase related protein (calcium- Erp70 1.36 binding protein, intestinal-related) NM_012939 Ctsh 1.36

NM_053440 -like 2 Stmn2 1.36 NM_012884 Contactin 2 Cntn2 1.36 AA799515 WD SOCS-box protein 2 Wsb2 1.35 BE104143 Tripartite motif protein 28 Trim28 1.35 NM_134335 Myosin IXA Myo9a 1.35 NM_053626 D-amino acid oxidase Dao1 1.35 L19927 ATP synthase, H+ transporting, mitochondrial F1 Atp5c1 1.35 complex, gamma polypeptide 1 NM_017355 RAB4B, member RAS oncogene family Rab4b 1.35

NM_012511 ATPase, Cu++ transporting, beta polypeptide Atp7b 1.35 NM_019143 1 Fn1 1.35 NM_022507 Protein kinase C, zeta Prkcz 1.35 NM_017181 Fumarylacetoacetate hydrolase Fah 1.35 AF180350 , regulatory subunit B, delta Ppp2r2d 1.35 isoform NM_031616 Zinc finger protein 265 Zfp265 1.35

18

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_057130 BH3 interacting (with BCL2 family) domain, Bid3 1.34 NM_030861 Alpha-1,3-mannosyl-glycoprotein 2-beta-N- Mgat1 1.34 acetylglucosaminyltransferase BE101096 Pre-B-cell leukemia transcription factor 2 Pbx2 1.34

NM_019335 Protein kinase, -inducible double stranded RNA Prkr 1.34 dependent NM_031509 Glutathione S- A5 Gsta5 1.34

NM_012914 ATPase, Ca++ transporting, ubiquitous Atp2a3 1.34 NM_057119 Splicing factor, arginine/serine-rich 10 (transformer 2 Sfrs10 1.34 homolog, Drosophila) NM_053337 Msx-interacting-zinc finger Miz1 1.34

AB073318 Brain and acute leukemia, cytoplasmic Baalc 1.33 AI406667 RAB5A, member RAS oncogene family Rab5a 1.33 NM_019354 Uncoupling protein 2 Ucp2 1.33 NM_017068 Lysosomal membrane glycoprotein 2 Lamp2 1.33 NM_017108 Potassium voltage-gated channel, subfamily H (eag- Kcnh3 1.33 related), member 3 X74125 3, gamma Idh3g 1.33

AI179901 Transmembrane 9 superfamily member 2 Tm9sf2 1.33 NM_019356 Eukaryotic translation initiation factor 2, subunit 1 alpha Eif2s1 1.32 NM_012776 Adrenergic receptor kinase, beta 1 Adrbk1 1.32

AI412018 Cryptochrome 2 (photolyase-like) Cry2 1.32 NM_022193 Acetyl-coenzyme A carboxylase alpha Acaca 1.32 BE113146 Phenylalanine-tRNA synthetase-like, beta subunit Farslb 1.32 X95507 Y receptor Y1 Npy1r 1.32 NM_030862 MARCKS-like protein Mlp 1.32 NM_013047 Thyrotropin releasing hormone receptor Trhr 1.32 AI555565 HIV-1 tat interactive protein, homolog () Htatip 1.32 NM_130401 Membrane-associated protein 17 Map17 1.32 AW144044 Regulator of G-protein signalling 3 Rgs3 1.32 NM_031127 Sulfite oxidase Suox 1.31 NM_017340 Acyl-Coenzyme A oxidase 1, palmitoyl Acox1 1.31 NM_031676 Transgelin 3 Tagln3 1.31 NM_017285 Proteasome (prosome, macropain) subunit, beta type 3 Psmb3 1.31 AI146156 Solute carrier family 6 (neurotransmitter transporter, L- Slc6a7 1.31 proline), member 7 U75361 Unc-13 homolog C (C. elegans) Unc13c 1.31

NM_019255 Calcium channel, voltage-dependent, gamma subunit 1 Cacng1 1.31 BE121314 FK506-binding protein 1a Fkbp1a 1.31 BF389157 Similar to KIAA1401 protein (predicted) Srr 1.31 NM_030995 Microtubule-associated protein 1 A Mtap1a 1.31 AF155824 Kinesin heavy chain member 2 Kif2 1.31 NM_020076 3-hydroxyanthranilate 3,4-dioxygenase Haao 1.31

19

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_012562 , alpha-L- 1, tissue Fuca 1.31 NM_031520 Myosin heavy chain 10, non-muscle Myh10 1.31 NM_012846 1 Fgf1 1.31 BE105864 Pyruvate kinase, liver and RBC Pklr 1.31 BF407964 Nuclear receptor subfamily 1, group I, member 3 Nr1i3 1.30 BE104891 Rho guanine nucleotide exchange factor 7 Arhgef7 1.30 AA892300 Peroxisome biogenesis factor 5 (predicted) Pex5 1.30 NM_053907 I-like 3 Dnase1l3 1.30 NM_012554 1, alpha Eno1 1.30 NM_019275 MAD homolog 4 (Drosophila) Madh4 1.30 BF407480 SET and MYND domain containing 2 Smyd2 1.30 U77880 Phosphodiesterase 7A Pde7a 1.30 NM_057211 Basic transcription element binding protein 1 Bteb1 1.30 NM_012780 Aryl hydrocarbon receptor nuclear translocator Arnt 1.30 NM_134415 CDK105 protein Cdk105 1.30 AI009089 Karyopherin (importin) beta 1 Kpnb1 1.29 AA818727 Transcription elongation factor B (SIII), polypeptide 3 Tceb3 1.29 AI406275 Chromobox homolog 7 Cbx7 1.29 NM_012816 Alpha-methylacyl-CoA racemase Amacr 1.29 NM_032069 Glutamate receptor interacting protein 1 Grip1 1.29 NM_031604 ATPase, H+ transporting, lysosomal V0 subunit a isoform Atp6v0a1 1.29 1 BF563113 Plasticity related gene 1 Prg1 1.28

NM_031646 Receptor () activity modifying protein 2 Ramp2 1.28 NM_054000 Potassium voltage gated channel, Shab-related Kcnb2 1.27 subfamily, member 2 AW916347 Sphingomyelin phosphodiesterase 1, acid lysosomal Smpd1 1.27

NM_012680 2 Tsc2 1.27 NM_019243 Prostaglandin F2 receptor negative regulator Ptgfrn 1.27 NM_031680 Pyrimidinergic receptor P2Y, G-protein coupled, 4 P2ry4 1.27 NM_022264 V- Hardy-Zuckerman 4 feline sarcoma viral oncogene Kit 1.26 homolog NM_031110 Ribosomal protein S11 Rps11 1.25

BG666690 B-cell receptor-associated protein 31 MGC9422 1.25 1 NM_057136 Epsin 1 Epn1 1.25 NM_017145 protease 1 Mcpt1 1.25 NM_012818 Arylalkylamine N-acetyltransferase Aanat 1.23 NM_053596 Endothelin converting enzyme 1 Ece1 0.80 NM_019272 Semaphorin 4f Sema4f 0.80 BF419646 Retinoic acid receptor, beta Rarb 0.80 NM_133539 Mitochondrial ribosomal protein L17 Mrpl17 0.80 AI176608 complex, subunit D, integral Sdhd 0.79 membrane protein BE111691 Ras-related C3 botulinum toxin substrate 1 Rac1 0.79

AI598306 Four and a half LIM domains 1 Fhl1 0.79

20

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_031578 Testis specific protein kinase 1 Tesk1 0.79 AI013385 MHC class I-like sequence Hlals 0.79 NM_012930 Carnitine palmitoyltransferase 2 Cpt2 0.79 AI172041 TAF9 RNA polymerase II, TATA box binding protein Taf9 0.78 (TBP)-associated factor NM_030848 Bone marrow stromal cell antigen 1 Bst1 0.78

AW254010 NADH dehydrogenase (ubiquinone) Fe-S protein 7 Ndufs7 0.78 (predicted) NM_017326 Calmodulin 2 Calm2 0.78

NM_053483 Karyopherin (importin) alpha 2 Kpna2 0.78 NM_013216 Ras homolog enriched in brain Rheb 0.78 M64780 Agrn 0.78 NM_053865 Reticulon 1 Rtn1 0.78 NM_012754 receptor 2 beta Esr2 0.78 NM_012819 Acetyl-Coenzyme A dehydrogenase, long-chain Acadl 0.77 NM_133303 Basic helix-loop-helix domain containing, class B3 Bhlhb3 0.77 NM_031042 General transcription factor IIF, polypeptide 2 Gtf2f2 0.77 AI177155 NAD(P) dependent dehydrogenase-like Nsdhl 0.77 NM_012876 Ribosomal protein S29 Rps29 0.77 NM_012522 Cystathionine beta synthase Cbs 0.77 NM_054009 Chymotrypsin-like Ctrl 0.77 AW252110 Small fragment nuclease (predicted) Smfn 0.77 NM_017158 Cytochrome P450, family 2, subfamily c, polypeptide 7 Cyp2c39 0.77 NM_019303 Cytochrome P450, family 2, subfamily f, polypeptide 2 Cyp2f2 0.77 NM_053756 ATP synthase, H+ transporting, mitochondrial F0 Atp5g3 0.77 complex, subunit c (subunit 9) isoform 3 AW251878 Crystallin, alpha C Cryac 0.77

AF205635 Cell division cycle 42 homolog (S. cerevisiae) Cdc42 0.77 AI235942 Aquaporin 4 Aqp4 0.76 NM_031073 3 Ntf3 0.76 NM_031138 Ubiquitin conjugating enzyme LOC8181 0.76 6 D82928 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Cdipt 0.76 (phosphatidylinositol synthase) BE113043 Eukaryotic translation initiation factor 2B, subunit 5 Eif2b5 0.76 epsilon NM_031725 Secretory carrier membrane protein 4 Scamp4 0.76

BG665561 Abhydrolase domain containing 6 Abhd6 0.76 AW144760 Replication factor C (activator 1) 3 (predicted) Rfc3 0.76 D12771 Solute carrier family 25 (mitochondrial carrier; adenine Slc25a5 0.76 nucleotide translocator), member 5 AI411391 deacetylase 6 Hdac6 0.76

AW141939 Ras homolog gene family, member A Rhoa 0.76 D63772 Solute carrier family 1 (neuronal/epithelial high affinity Slc1a1 0.76 , system Xag), member 1

21

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_013019 RAB4A, member RAS oncogene family Rab4a 0.75

AB071986 ELOVL family member 6, elongation of long chain fatty Elovl6 0.75 acids (yeast) NM_017080 Hydroxysteroid 11-beta dehydrogenase 1 Hsd11b1 0.75

NM_031557 Prostaglandin I2 () synthase Ptgis 0.75 NM_133600 Solute carrier family 31 (copper transporters), member 1 Slc31a1 0.75 NM_013120 regulatory protein Gckr 0.75

NM_053969 G protein pathway suppressor 1 Gps1 0.75 NM_138536 Tubulin tyrosine ligase Ttl 0.75 NM_021758 Lin-7 homolog b (C. elegans) Lin7b 0.75 NM_053986 Myosin Ib Myo1b 0.75 NM_080397 Carbohydrate sulfotransferase 10 Chst10 0.75 NM_031801 Deformed epidermal autoregulatory factor 1 (Drosophila) Deaf1 0.75 NM_012853 5-hydroxytryptamine (serotonin) receptor 4 Htr4 0.75

NM_031645 Receptor (calcitonin) activity modifying protein 1 Ramp1 0.74 X94186 Dual specificity phosphatase 7 Dusp7 0.74 NM_080899 Inhibitor of kappa light polypeptide enhancer in B-cells, Ikbkap 0.74 kinase complex-associated protein AI411156 Osteoclast stimulating factor 1 Ostf1 0.74

U80076 Ras and interactor 1 Rin1 0.74 U30789 Upregulated by 1,25-dihydroxyvitamin D-3 Txnip 0.74 AF120111 Fasciculation and elongation protein zeta 2 (zygin II) Fez2 0.74 BF282313 Frizzled homolog 5 (Drosophila) Fzd5 0.74 BF284818 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) Bdh 0.74 NM_013179 Hypocretin HcRt 0.74

NM_134468 Calcium/calmodulin-dependent protein kinase I Camk1 0.74 NM_012601 N-methylpurine-DNA Mpg 0.74 NM_012617 receptor, delta 1 Oprd1 0.74 NM_012528 Cholinergic receptor, nicotinic, beta polypeptide 1 Chrnb1 0.74 (muscle) NM_031605 Cytochrome P450, 4a12 Cyp4a12 0.74

AF335571 Echinoderm microtubule associated protein like 2 Eml2 0.74 U12402 ADP-ribosylation factor-like 1 Arl1 0.74 NM_012661 Sts 0.74 BF287032 WW domain binding protein 2 Wbp2 0.74 AI007985 EGL nine homolog 1 (C. elegans) Egln1 0.74 BF398155 Cyclin F Ccnf 0.74 NM_012689 1 Esr1 0.73 BF281200 Platelet-activating factor acetylhydrolase, isoform Ib, Pafah1b1 0.73 alpha subunit 45kDa NM_013113 ATPase, Na+/K+ transporting, beta 1 polypeptide Atp1b1 0.73

X55995 Dimethylglycine dehydrogenase precursor Dmgdh 0.73

22

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_012851 Hydroxysteroid (17-beta) dehydrogenase 1 Hsd17b1 0.73 BF282471 Lymphocyte cytosolic protein 2 Lcp2 0.73 AA819268 Phosphatidylinositol 3-kinase, regulatory subunit, Pik3r1 0.73 polypeptide 1 NM_030828 Glypican 1 Gpc1 0.73

NM_012838 Cystatin B Cstb 0.73 NM_031798 Solute carrier family 12, member 2 Slc12a2 0.73 L35921 Guanine nucleotide binding protein (G protein), gamma 8 Gng8 0.73 subunit NM_133572 Cell division cycle 25 homolog B (S. cerevisiae) Cdc25b 0.73

NM_017176 Phospholipase A2, group X Pla2g10 0.73 NM_019282 Cysteine knot superfamily 1, BMP antagonist 1 Cktsf1b1 0.73 BF408285 Brain-specific angiogenesis inhibitor 1-associated protein Baiap2 0.73 2 BF281357 Calmodulin 1 Calm1 0.72

NM_134363 Solute carrier family 12, (potassium-chloride transporter) Slc12a5 0.72 member 5 NM_016988 2, lysosomal Acp2 0.72

NM_133397 V-ets erythroblastosis virus E26 oncogene like (avian) Erg 0.72 NM_012605 Myosin, light polypeptide 2 Myl2 0.72 NM_053291 1 Pgk1 0.72 NM_013161 Pancreatic lipase Pnlip 0.72 NM_053319 Dynein, cytoplasmic, light chain 1 Dnclc1 0.72 AF130457 Rous sarcoma oncogene Src 0.71 NM_012592 Isovaleryl coenzyme A dehydrogenase Ivd 0.71 NM_019136 Arginine receptor 2 Avpr2 0.71 NM_080786 Solute carrier organic anion transporter family, member Slco2b1 0.71 2b1 L19699 V-ral simian leukemia viral oncogene homolog B Ralb 0.71

NM_012981 Muscle and microspikes RAS Mras 0.71 NM_019230 Solute carrier family 22, member 3 Slc22a3 0.71 AW916778 Gem (nuclear organelle) associated protein 6 (predicted) Gemin6 0.71 NM_017195 Growth associated protein 43 Gap43 0.71

NM_130740 Protein kinase C and casein kinase substrate in Pacsin2 0.71 2 NM_031151 , mitochondrial Mor1 0.71

NM_019224 Regulator of G-protein signaling 9 Rgs9 0.71 NM_019368 Blocked early in transport 1 homolog (S.cerevisiae) Bet1 0.71 NM_057196 Brain-specific angiogenesis inhibitor 1-associated protein Baiap2 0.71 2 BF415760 Protein kinase, AMP-activated, gamma 2 non-catalytic Prkag2 0.71 subunit NM_020087 Notch gene homolog 3 (Drosophila) Notch3 0.71

23

Downloaded from iovs.arvojournals.org on 09/30/2021 BE099063 P75-like apoptosis-inducing protein LOC2461 0.71 PLAIDD 43 NM_012789 Dipeptidylpeptidase 4 Dpp4 0.71

AI411962 Peptidylprolyl isomerase C Ppic 0.71 NM_033359 Neuroglobin Ngb 0.71 AW915448 Solute carrier family 22 (organic cation transporter), Slc22a17 0.71 member 17 NM_012687 Thromboxane A synthase 1 Tbxas1 0.70

NM_017300 -Coenzyme A: amino acid N-acyltransferase Baat 0.70 NM_017250 5-hydroxytryptamine (serotonin) receptor 2B Htr2b 0.70 NM_031136 , beta 4 Tmsb4x 0.70 NM_131907 ATPase, Ca++-sequestering Atp2c1 0.70 NM_017154 Xanthine dehydrogenase Xdh 0.70 L25527 , endothelial cell Sele 0.70 AW917376 Mitochondrial ribosomal protein L11 0.70 NM_053906 Glutathione reductase Gsr 0.70 NM_013075 Homeo box A1 Hoxa1 0.70 NM_021702 Ataxin 3 Atxn3 0.70 NM_017175 Pkn1 0.70 BF288063 Component of oligomeric golgi complex 6 Cog6 0.70 D13963 Glutamate receptor, metabotropic 6 Grm6 0.70 NM_078623 Enoyl Coenzyme A hydratase, short chain, 1, Echs1 0.70 mitochondrial BG670966 Tryptophanyl-tRNA synthetase Wars 0.70

NM_053430 Flap structure-specific 1 Fen1 0.70 X98490 Replication protein A2 Rpa2 0.70 NM_057197 2,4-dienoyl CoA reductase 1, mitochondrial Decr1 0.70 U39208 Cytochrome P450 4F6 Cyp4f6 0.70 AI406350 Restin (Reed-Steinberg cell-expressed intermediate Rsn 0.70 filament-associated protein) NM_017335 Solute carrier family 6 (neurotransmitter transporter, Slc6a12 0.70 betaine/GABA), member 12 NM_017194 Cholinergic receptor, nicotinic, epsilon polypeptide Chrne 0.70

AA892897 Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 Plod2 0.69 NM_053669 Adaptor protein with pleckstrin homology and src Aps 0.69 homology 2 domains AI233786 Ribosomal protein L22 Rpl22 0.69

NM_013098 Glucose-6-phosphatase, catalytic G6pc 0.69 NM_080581 ATP-binding cassette, sub-family C (CFTR/MRP), Abcc3 0.69 member 3 U18650 Huntington disease gene homolog Hdh 0.69

M29853 Cytochrome P450, family 4, subfamily b, polypeptide 1 Cyp4b1 0.69 AI009597 FXYD domain-containing transport regulator 3 Fxyd3 0.69 BG666149 Heat shock factor binding protein 1 Hsbp1 0.69

24

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_053880 Dynein, cytoplasmic, intermediate polypeptide 2 Dncic2 0.69 NM_021262 Acid phosphatase 1, soluble Sos1 0.69 NM_057188 monophosphate reductase Gmpr 0.69 AF016047 Platelet-activating factor acetylhydrolase, isoform 1b, Pafah1b3 0.69 alpha1 subunit NM_019311 Inositol polyphosphate-5-phosphatase D Inpp5d 0.69

AW918443 Similar to calcyclin binding protein MGC9392 0.68 1 BF564840 A kinase (PRKA) anchor protein 6 Akap6 0.68 NM_019229 Solute carrier family 12, member 4 Slc12a4 0.68 U80054 MutL homolog 1 (E. coli) Mlh1 0.68 AF102854 Membrane-associated -interacting Cnksr2 0.68 protein NM_013185 Hemopoietic cell kinase Hck 0.68

AI011448 Notch gene homolog 2, (Drosophila) Notch2 0.68 NM_031986 Syndecan binding protein Sdcbp 0.68 AF072835 CD48 antigen Cd48 0.68 AW530773 Tumor protein D52-like 2 Tpd52l2 0.68 AI412108 Putative scaffolding protein POSH Sh3md2 0.68 NM_053555 Vesicle-associated membrane protein 5 Vamp5 0.68 NM_017359 Rab10 0.68 NM_031741 Slc2a5 0.68 NM_017063 Karyopherin (importin) beta 1 Kpnb1 0.68 AI172033 Arginine- dipeptide (RE) repeats Rere 0.68 NM_012968 Interleukin 1 receptor accessory protein Il1rap 0.68 NM_031833 Expressed in non-metastatic cells 2 Nme2 0.68 AW916925 Epimorphin Epim 0.68 NM_053631 Barrier to autointegration factor 1 Banf1 0.68 AW918385 Prickle-like 1 (Drosophila) Prickle1 0.68 NM_053625 G elongation factor Gfm 0.68 NM_078621 Chemokine binding protein 2 Ccbp2 0.68 AW919666 LIM and cysteine-rich domains 1 (predicted) LIMD1 0.68 NM_019286 dehydrogenase 1 Adh1 0.68 NM_053886 Lectin, mannose-binding, 1 Lman1 0.68 NM_031672 Solute carrier family 15 (H+/peptide transporter), member Slc15a2 0.67 2 NM_053719 Embigin Emb 0.67

NM_013196 Peroxisome proliferator activated receptor alpha Ppara 0.67 U62316 Solute carrier family 16 (monocarboxylic acid Slc16a7 0.67 transporters), member 7 NM_019152 Calpain 1 Capn1 0.67

NM_024405 Axin 1 Axin1 0.67 NM_019187 Coenzyme Q3 homolog, (yeast) Coq3 0.67 NM_053434 Transient receptor potential cation channel, subfamily C, Trpc4 0.67 member 4

25

Downloaded from iovs.arvojournals.org on 09/30/2021 M92076 Glutamate receptor, metabotropic 3 Grm3 0.67

NM_020097 Exostoses (multiple)-like 3 Extl3 0.67 NM_013182 Mc5r 0.67 NM_017014 Glutathione S-transferase, mu 1 Gstm1 0.67 NM_021848 -like peptide 2 receptor Glp2r 0.67 NM_012543 D site albumin binding protein Dbp 0.67 NM_013036 4 Sstr4 0.67 NM_024377 Guanine nucleotide binding protein (G protein), gamma 5 Gng5 0.67 subunit NM_012798 Myelin and lymphocyte protein Mal 0.67

NM_013197 Aminolevulinic acid synthase 2 Alas2 0.66 NM_031536 Mitochondrial capsule selenoprotein Mcsp 0.66 NM_017136 Squalene epoxidase Sqle 0.66 AI171803 family 6, subfamily A1 Mmsdh 0.66 AI412180 Glutathione reductase Gsr 0.66 AW143101 Synaptosomal-associated protein 29 Snap29 0.66 BE100064 Neural precursor cell expressed, developmentally down- Nedd4l 0.66 regulated 4-like AF255888 SH3-domain kinase binding protein 1 Sh3kbp1 0.66

BF398045 Outer dense fiber of sperm tails 2 Odf2 0.66 BF399595 DMT1-associated protein Acbd3 0.66 NM_019179 Thymidylate synthase Tyms 0.66 AI236953 Serine palmitoyltransferase, long chain base subunit 1 Sptlc1 0.66 (predicted) NM_053528 Polymerase (DNA directed), gamma Polg 0.66

AF036537 Receptor-interacting serine-threonine kinase 3 Ripk3 0.66 NM_013138 Inositol 1, 4, 5-triphosphate receptor 3 Itpr3 0.66 NM_031785 ATPase, H+ transporting, lysosomal (vacuolar proton Atp6ap1 0.66 pump), subunit 1 NM_013168 Hydroxymethylbilane synthase Hmbs 0.66

X83579 Cyclin-dependent kinase 7 (homolog of Xenopus MO15 Cdk7 0.66 cdk-activating kinase) NM_012956 Gamma-aminobutyric acid receptor, subunit beta 1 Gabrb1 0.66

NM_032072 precursor protein binding protein 1 Appbp1 0.66 NM_012667 1 Tacr1 0.66 BG666773 V-ros UR2 sarcoma virus oncogene homolog 1 (avian) Ros1 0.66 NM_012768 Drd5 0.65 AW534329 Ribosomal protein L28 Rpl28 0.65 M35297 MAS-related GPR, member F Mrgprf 0.65 NM_017048 Solute carrier family 4, member 2 Slc4a2 0.65 NM_031354 Voltage-dependent anion channel 2 Vdac2 0.65 NM_013006 1 Lypla1 0.65 NM_031985 Ribosomal protein S6 kinase, polypeptide 1 Rps6kb1 0.65 NM_012792 Flavin containing monooxygenase 1 Fmo1 0.65

26

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_019291 2 Ca2 0.65 NM_053924 ATP-binding cassette, sub-family C (CFTR/MRP), Abcc5 0.65 member 5 AW913868 Trafficking protein particle complex 4 Trappc4 0.65

NM_030852 Cartilage derived retinoic acid sensitive protein Mia 0.65 AF068861 Defensin beta 3 Defb3 0.65 NM_133511 Adenylate cyclase activating polypeptide 1 receptor 1 Adcyap1r1 0.65 NM_017304 Potassium voltage-gated channel, shaker-related Kcnab2 0.65 subfamily, beta member 2 NM_134365 ATP synthase, H+ transporting, mitochondrial F0 Atp5f1 0.65 complex, subunit b, isoform 1 AA859006 Myosin Ib Myo1b 0.65

NM_031016 Cholinergic receptor, muscarinic 2 Chrm2 0.65 NM_019318 V- musculoaponeurotic fibrosarcoma (avian) Maf 0.65 oncogene homolog (c-maf) NM_133406 1-acylglycerol-3-phosphate O-acyltransferase 4 Agpat4 0.65

NM_012845 Membrane-spanning 4-domains, subfamily A, member 2 Ms4a2 0.65 NM_031095 binding protein Renbp 0.64

AW915566 Glyoxylase 1 Glo1 0.64 U68544 Peptidylprolyl isomerase F (cyclophilin F) Ppif 0.64 NM_031012 Alanyl (membrane) aminopeptidase Anpep 0.64 NM_053601 Neuronatin Nnat 0.64 X61677 Inositol 1,4,5-triphosphate receptor 2 Itpr2 0.64 NM_078619 Solute carrier family 8 (sodium/calcium exchanger), Slc8a2 0.64 member 2 NM_012557 , complementation group C Fancc 0.64

AI169160 ElaC homolog 2 (E. coli) Elac2 0.64 AF102262 UDP-Gal:betaGlcNAc beta 1,4- , B4galt1 0.64 polypeptide 1 U36444 PCTAIRE-motif protein kinase 1 Pctk1 0.64

BF288088 ATPase, Na+/K+ transporting, beta 3 polypeptide Atp1b3 0.64 NM_017142 8 Adcy8 0.64 NM_022946 Discs, large (Drosophila) homolog-associated protein 1 Dlgap1 0.64 NM_012908 Tumor necrosis factor (ligand) superfamily, member 6 Tnfsf6 0.64 BE108810 Notch gene homolog 1, (Drosophila) Notch1 0.64 U86635 Glutathione S-transferase, mu 5 Gstm5 0.64 NM_031782 Vesicular inhibitory amino acid transporter Viaat 0.64 NM_031735 Serine/threonine kinase 3 Stk3 0.64 NM_031236 1 Fut1 0.64 BF407203 Guanosine monophosphate reductase 2 Gmpr2 0.64 NM_031802 G protein-coupled receptor 51 Gpr51 0.63 U30831 B/K protein Bk 0.63 NM_013166 Ciliary neurotrophic factor Cntf 0.63 NM_012624 Pyruvate kinase, liver and RBC Pklr 0.63

27

Downloaded from iovs.arvojournals.org on 09/30/2021 AI178763 Unknown (protein for MGC:72959) Commd3 0.63 NM_020084 Calcium channel, voltage-dependent, alpha 1I subunit Cacna1i 0.63 NM_052981 Cyclin H Ccnh 0.63 NM_012959 Glial cell line derived neurotrophic factor family receptor Gfra1 0.63 alpha 1 NM_017015 Glucuronidase, beta Gusb 0.63

U89531 Ttn 0.63 NM_012911 , beta 2 Arrb2 0.63 AI411217 Apoptosis-associated speck-like protein containing a Pycard 0.63 CARD AJ223083 gamma Rxrg 0.62

AI102047 DNA-damage inducible transcript 3 Ddit3 0.62 NM_012861 O-6-methylguanine-DNA methyltransferase Mgmt 0.62 AI235238 Heat shock factor binding protein 1 Hsbp1 0.62 BF408094 Sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta- Siat7A 0.62 galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6- sialyltransferase) A AI171802 3 Ak3 0.62

M37394 receptor Egfr 0.62 NM_024487 GrpE-like 1, mitochondrial Grpel1 0.62 NM_053687 CDK107 Slfn3 0.62 U05989 PRKC, apoptosis, WT1, regulator Pawr 0.62 NM_031014 5-aminoimidazole-4-carboxamide ribonucleotide Atic 0.62 formyltransferase/IMP cyclohydrolase NM_053800 Thioredoxin Txn 0.62

AI178808 receptor, gamma (severe combined Il2rg 0.62 immunodeficiency) NM_032060 Complement component 3a receptor 1 C3ar1 0.62

AA800744 -like Calcrl 0.62 NM_012565 Glucokinase Gck 0.62 BF566679 Protein phosphatase 1A, magnesium dependent, alpha Ppm1a 0.62 isoform NM_017257 Protease (prosome, macropain) 28 subunit, beta Psme2 0.62

AI411530 Aminoacylase 1 Acy1 0.62 NM_024391 Hydroxysteroid (17-beta) dehydrogenase 2 Hsd17b2 0.61 NM_030855 Ligase I, DNA, ATP-dependent Lig1 0.61 AI169829 Mannan-binding lectin serine Masp1 0.61 NM_032075 secretagogue receptor Ghsr 0.61 NM_012527 Cholinergic receptor, muscarinic 3 Chrm3 0.61 NM_021847 Vesicle-associated membrane protein, associated protein Vapb 0.61 B and C NM_019274 Collagen-like tail subunit (single strand of homotrimer) of Colq 0.61 asymmetric

28

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_053590 Proteasome (prosome, macropain) subunit, beta type 1 Psmb1 0.61

Y09164 Sodium channel, voltage-gated, type 6, alpha Scn6a 0.61 polypeptide NM_031029 Gamma-aminobutyric acid (GABA) A receptor, pi Gabrp 0.61

X73371 Fc receptor, IgG, low affinity IIb Fcgr2b 0.61 NM_017345 Neural L1 NCAML1 0.61 NM_017229 Phosphodiesterase 3B Pde3b 0.61 NM_053529 MHC class II transactivator C2ta 0.61 BE118450 Retinoid X receptor gamma Rxrg 0.61 BE101290 Platelet derived growth factor receptor, beta polypeptide Pdgfrb 0.61 NM_031115 receptor Sctr 0.61 AF051943 Expressed in non-metastatic cells 6, protein (nucleoside Nme6 0.61 diphosphate kinase) NM_130746 Solute carrier family 5 (sodium-dependent Slc5a6 0.61 transporter), member 6 BG666856 Solute carrier family 4, sodium bicarbonate transporter- Slc4a10 0.60 like, member 10 U75392 B-cell receptor-associated protein 37 Bcap37 0.60

U57362 Procollagen, type XII, alpha 1 Col12a1 0.60 AA799981 Protein kinase C, eta Prkch 0.60 NM_012731 Neurotrophic tyrosine kinase, receptor, type 2 Ntrk2 0.60 NM_053974 Eukaryotic translation initiation factor 4E Eif4e 0.60 NM_030829 G protein-coupled receptor kinase 5 Gprk5 0.60 NM_019211 RAS guanyl releasing protein 1 Rasgrp1 0.60 BE110577 Calcium regulated heat stable protein 1 Carhsp1 0.60 AI009029 Translocase of inner mitochondrial membrane 22 Timm22 0.60 homolog (yeast) NM_012619 Phenylalanine hydroxylase Pah 0.60

BF409296 Phosphatidylinositol glycan, class A Piga 0.60 NM_057127 Solute carrier family 26 (), member 2 Slc26a2 0.60 NM_031118 Sterol O-acyltransferase 1 Soat1 0.60 AF072439 Zinc finger protein 37 Zfp37 0.60 AI010722 Cyclin-dependent kinase 9 Cdk9 0.60 NM_031612 , AGTRL1 ligand Apln 0.60 BE108968 Endothelial differentiation, G- Edg2 0.60 protein-coupled receptor, 2 NM_017129 Ctf1 0.60

NM_053415 Chemokine (C-X-C motif) receptor 3 Cxcr3 0.60 NM_017143 Coagulation factor X F10 0.60 NM_019367 Palmitoyl-protein 2 Ppt2 0.60 NM_013029 Sialyltransferase 8 C Siat8c 0.59 NM_017243 Phosphoribosyl pyrophosphate synthetase 1 Prps1 0.59 U46149 Demethyl-Q 7 Coq7 0.59 M94043 Rab38, member of RAS oncogene family Rab38 0.59 NM_031569 -like Oprl 0.59

29

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_012896 Adora3 0.59 NM_012733 Retinol binding protein 1, cellular Rbp1 0.59 NM_012921 Cartilage homeo protein 1 Cart1 0.59 BG665133 Guanine nucleotide binding protein, gamma 2 Gng2 0.59 NM_053508 1 Tekt1 0.59 AA892905 Myotrophin Mtpn 0.59 NM_031786 Tripartite motif protein 3 Trim3 0.59 NM_017264 Protease (prosome, macropain) 28 subunit, alpha Psme1 0.59 NM_013114 Selectin, platelet Selp 0.58 AI233199 Flavin containing monooxygenase 5 Fmo5 0.58 AF036335 NonO/p54nrb homolog Sfpq 0.58 AA891830 COMM domain containing 10 Commd10 0.58 NM_019202 Phospholipase A2, group 2C Pla2g2c 0.58 AI230228 Phosphoserine aminotransferase 1 Psat1 0.58 NM_031055 Matrix metallopeptidase 9 Mmp9 0.58 NM_053948 Polymerase (RNA) II (DNA directed) polypeptide G Polr2g 0.58 AB026665 Peptide/histidine transporter PHT2 Slc15a3 0.58 NM_012916 Brevican Bcan 0.58 NM_017053 Tacr3 0.58 AW533321 Fatty acid desaturase 3 Fads3 0.58 NM_031348 Ficolin A Fcna 0.58 M94040 Branched chain keto acid dehydrogenase E1, beta Bckdhb 0.58 polypeptide NM_053464 Spermidine synthase Srm 0.58

NM_013187 Phospholipase C, gamma 1 Plcg1 0.58 M64376 1078 Olr1078 0.58 NM_053973 Ras-related GTP-binding protein ragA Rraga 0.57 AI598359 Tumor necrosis factor, alpha-induced protein 1 Tnfaip1 0.57 (endothelial) BE113599 ATP-binding cassette, sub-family C (CFTR/MRP), Abcc9 0.57 member 9 NM_133610 Potassium voltage-gated channel, subfamily H (eag- Kcnh5 0.57 related), member 5 NM_021745 Nuclear receptor subfamily 1, group H, member 4 Nr1h4 0.57

NM_013215 Aldo-keto reductase family 7, member A3 (aflatoxin Akr7a3 0.57 aldehyde reductase) BF282899 Cyclin-dependent kinase inhibitor 2C (p18, inhibits Cdkn2c 0.57 CDK4) NM_024361 N-deacetylase/N-sulfotransferase (heparan Ndst1 0.57 glucosaminyl) 1 AI412239 McKusick-Kaufman syndrome protein (predicted) Mkks 0.57

NM_080399 DNA-damage-inducible transcript 4-like Ddit4l 0.57 AI070523 Similar to RIKEN cDNA 1810020G14 (predicted) Adam4 0.57 U76551 Mucin 3 Muc3 0.57 NM_013010 Protein kinase, AMP-activated, gamma 1 non-catalytic Prkag1 0.57 subunit

30

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_053551 kinase, isoenzyme 4 Pdk4 0.57

AF077354 Heat shock protein 4 Hspa4 0.57 NM_017093 Murine thymoma viral (v-akt) oncogene homolog 2 Akt2 0.56 AA800241 ADP-ribosylation factor-like 6 interacting protein 5 Arl6ip5 0.56 BF420163 CEA-related cell adhesion molecule 1 Ceacam1 0.56 NM_053827 Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 Plod1 0.56 NM_053686 Transient receptor potential cation channel, subfamily V, Trpv6 0.56 member 6 AI716902 Ribosomal protein L21 Rpl21 0.56

D12770 Solute carrier family 25 (mitochondrial adenine Slc25a4 0.56 nucleotide translocator) member 4 NM_133299 Peroxisomal trans-2-enoyl-CoA reductase Pecr 0.56

NM_012985 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Ndufa5 0.56 5 U46118 Cytochrome P450, family 3, subfamily a, polypeptide 13 Cyp3a13 0.56

NM_012793 Guanidinoacetate methyltransferase Gamt 0.56

NM_133593 Adaptor-related protein complex 3, mu 1 subunit Ap3m1 0.56 NM_053352 Chemokine orphan receptor 1 Cmkor1 0.56 NM_053487 Peroxisomal biogenesis factor 11A Pex11a 0.56 BF288129 Protein tyrosine phosphatase, receptor type, C Ptprc 0.56 NM_053445 Fatty acid desaturase 1 Fads1 0.55 NM_012724 Fc receptor, IgE, high affinity I, alpha polypeptide Fcer1a 0.55 AF013598 Amiloride-sensitive cation channel 3 Accn3 0.55 NM_012931 anti-estrogen resistance 1 Bcar1 0.55 NM_012957 Gamma-aminobutyric acid receptor, subunit beta 2 Gabrb2 0.55 NM_013159 Insulin degrading enzyme Ide 0.55 NM_012739 Adrenergic receptor, alpha 2a Adra2a 0.55 NM_053936 Endothelial differentiation, lysophosphatidic acid G- Edg2 0.55 protein-coupled receptor, 2 AI179236 C1q and tumor necrosis factor related protein 1 C1qtnf1 0.55

X65036 Itga7 0.55 AF095740 Neural precursor cell expressed, developmentally down- Nedd8 0.54 regulated gene 8 NM_031093 V-ral simian leukemia viral oncogene homolog A (ras Rala 0.54 related) V01224 Actin, alpha 1, Acta1 0.54

AI412958 Pp 0.54 NM_012778 Aqp1 0.54 NM_022245 Cytochrome b-5 Cyb5 0.54 AI177621 Intercellular adhesion molecule 2 Icam2 0.54 NM_031539 CD8 antigen, beta chain Cd8b 0.54 L02530 Frizzled homolog 2 (Drosophila) Fzd2 0.54 NM_031726 Secretory carrier membrane protein 5 Scamp5 0.54

31

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_017064 Signal transducer and activator of transcription 5A Stat5a 0.54 NM_031750 Heat shock 27kD , member 3 Hspb3 0.54 NM_031827 Vesicle-associated membrane protein 8 Vamp8 0.54 NM_134381 Syne1 0.54 AW915551 Neural cell adhesion molecule 2 Ncam2 0.54 AW916468 ATPase, H+ transporting, lysosomal accessory protein 2 Atp6ap2 0.54 NM_017207 Transient receptor potential cation channel, subfamily V, Trpv2 0.54 member 2 BE101311 2,3-bisphosphoglycerate mutase Bpgm 0.53

AF236130 Disabled homolog 2 (Drosophila) interacting protein Dab2ip 0.53 U66322 12-hydroxydehydrogenase Ltb4dh 0.53 NM_053507 Non-metastatic cells 3, protein expressed in Nme3 0.53 NM_017138 Laminin receptor 1 (67kD, ribosomal protein SA) Lamr1 0.53 J04035 Elastin Eln 0.53 NM_053567 Formiminotransferase cyclodeaminase Ftcd 0.53 NM_017000 NAD(P)H dehydrogenase, quinone 1 Nqo1 0.53 NM_021661 Regulator of G-protein signaling 19 Rgs19 0.52 BE111625 Secreted phosphoprotein 1 Spp1 0.52 NM_012870 Tumor necrosis factor receptor superfamily, member 11b Tnfrsf11b 0.52 () NM_013174 Transforming growth factor, beta 3 Tgfb3 0.52

NM_019295 CD5 antigen Cd5 0.52 2.02 NM_053338 Ras-related associated with Rrad 0.52 NM_080477 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Pfkfb2 0.52 AW921113 SEC23A (S. cerevisiae) (predicted) Sec23a 0.52 BG485865 , X breakpoint 2 interacting protein Ssx2ip 0.52 X16261 Myosin heavy chain 11 Myh11 0.52 AB022714 Signal peptidase 21kDa subunit Spc21 0.52 AF311727 1 Angpt1 0.52 NM_019265 Sodium channel, voltage-gated, type11, alpha Scn11a 0.51 polypeptide D25290 Cadherin 6 Cdh6 0.51

AI235674 Short form of beta II Spnb2 0.51 AA944047 C-terminal binding protein 2 Ctbp2 0.51 NM_019168 Arginase 2 Arg2 0.51 L43592 Protocadherin 3 Pcdh3 0.51 NM_057137 Phenylalkylamine Ca2+ antagonist (emopamil) binding Ebp 0.51 protein NM_017111 Solute carrier family 21, member 1 Slc21a1 0.51

AW143362 Putative homeodomain transcription factor 1 Phtf1 0.51 AA945166 Multiple coagulation factor deficiency 2 Mcfd2 0.50 BE105541 Cytochrome P450, family 26, subfamily b, polypeptide 1 Cyp26b1 0.50 AI103682 Polymerase (DNA directed), alpha 1 Pola1 0.50

AI411531 COP9 signalosome subunit 4 Cops4 0.50 NM_133590 Ras-related GTP-binding protein Rab29 Rab7l1 0.50

32

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_019134 Solute carrier family 12, member 1 Slc12a1 0.50 AA892824 Tnc 0.50 NM_012675 Tumor necrosis factor superfamily, member 2 Tnf 0.50 AF020046 Integrin, alpha E, epithelial-associated Itgae 0.50 NM_021587 Latent transforming growth factor beta binding protein 1 Ltbp1 0.50 NM_031727 LIM motif-containing protein kinase 1 Limk1 0.49 AI045026 Glutamine-fructose-6-phosphate transaminase 2 Gfpt2 0.49 2.52 NM_031746 Solute carrier family 13 (sodium-dependent dicarboxylate Slc13a2 0.49 transporter), member 2 AI228222 General transcription factor IIF, polypeptide 2 Gtf2f2 0.49

NM_031719 Chloride channel, nucleotide-sensitive, 1A Clns1a 0.49 BF415017 Blocked early in transport 1 homolog (S. cerevisiae) like Bet1l 0.49 NM_012588 Insulin-like growth factor binding protein 3 Igfbp3 0.49

NM_013170 Gucy2c 0.49 BF405184 Endosulfine alpha Ensa 0.49 Z11690 Arginine 1A Avpr1a 0.48 X00469 Cytochrome P450, family 1, subfamily a, polypeptide 1 Cyp1a1 0.48 NM_012900 Ameloblastin Ambn 0.48 AI231802 Pln 0.48 0.49 NM_053957 Amyloid beta (A4) precursor protein-binding, family B, Apbb3 0.48 member 3 AI412143 Thioredoxin-like (32kD) Txnl1 0.48

AW142307 Adenosine deaminase Ada 0.48 NM_012613 receptor 1 Npr1 0.48 M64391 Olfactory receptor 226 Olfr41 0.47 NM_031723 Spc18 0.47 NM_019259 Complement component 1, q subcomponent binding C1qbp 0.47 protein NM_031336 Kl 0.47

AA891690 Tumor necrosis factor (ligand) superfamily, member 13 Tnfsf13 0.47 (predicted) AW918222 Torsin family 3, member A (predicted) Tor3a 0.47

BF284238 Prenylated SNARE protein Ykt6 0.47 AW254017 Collagen, type V, alpha 1 Col5a1 0.47 NM_017201 S-adenosylhomocysteine hydrolase Ahcy 0.47 U20194 Complement component 8, beta polypeptide C8b 0.47 NM_022591 associated protein 1 Tep1 0.47 AI012235 Chemokine (C-X-C motif) ligand 11 Cxcl11 0.47 2.70 AI406520 Axl receptor tyrosine kinase Axl 0.47 NM_017079 CD1d1 antigen Cd1d1 0.46 NM_031097 Arginyl aminopeptidase (aminopeptidase B) Rnpep 0.46 J04731 Potassium voltage-gated channel, shaker-related Kcna2 0.46 subfamily, member 2 NM_012627 Protein kinase (cAMP dependent, catalytic) inhibitor beta Pkib 0.46

33

Downloaded from iovs.arvojournals.org on 09/30/2021 AI410943 Syntaxin 6 Stx6 0.46

NM_012810 Synaptonemal complex protein 1 Sycp1 0.46 NM_031116 Ccl5 0.45 NM_053634 Ficolin B Fcnb 0.45 2.32 NM_019352 Translocase of inner mitochondrial membrane 23 Hsd17b12 0.45 homolog (yeast) AF003598 Integrin, beta 7 Itgb7 0.45

BF405194 Transmembrane protein 8 (five membrane-spanning Tmem8 0.45 domains) (predicted) BE113966 maturation factor, gamma Gmfg 0.45

NM_130433 Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3- Acaa2 0.45 oxoacyl-Coenzyme A ) NM_031328 B-cell CLL/lymphoma 10 Bcl10 0.45

NM_053309 Homer homolog 2 (Drosophila) Homer2 0.44 NM_012719 Sstr1 0.44 D10655 Dihydrolipoamide S-acetyltransferase (E2 component of Dlat 0.44 pyruvate dehydrogenase complex) AA892798 Uterine sensitization-associated gene 1 protein Sostdc1 0.44

AI599048 A kinase (PRKA) anchor protein 13 Akap13 0.44 D88672 Phospholipase D2 Pld2 0.44 NM_021597 GERp95 Eif2c2 0.44 NM_012666 Tachykinin 1 Tac1 0.44 NM_057186 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short Hadhsc 0.44 chain BE117878 Collectin sub-family member 12 Colec12 0.44

U94856 1 Pon1 0.44 NM_013180 Itgb4 0.43 NM_053478 Phospholipase C, beta 2 Plcb2 0.43 AW920609 Apelin, AGTRL1 ligand Apln 0.43 NM_053785 Transmembrane 4 superfamily member 4 Tm4sf4 0.43 NM_012492 Adrenergic receptor, beta 2 Adrb2 0.43 AB022014 Proteasome (prosome, macropain) 26S subunit, non- Psmd10 0.43 ATPase, 10 X90475 Myosin binding protein C, slow type Mybpc1 0.43

AW252096 Fibroblast growth factor 12 Fgf12 0.43 NM_019206 Stk10 0.43 AW915304 Glycine amidinotransferase (L-arginine:glycine Gatm 0.43 amidinotransferase) Y00350 Uroporphyrinogen decarboxylase Urod 0.43

NM_138511 Glypican 2 (cerebroglycan) Gpc2 0.43 NM_031358 Potassium inwardly rectifying channel, subfamily J, Kcnj11 0.42 member 11

34

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_021654 Gap junction membrane channel protein alpha 4 Gja4 0.42

BF550401 Chaperonin containing TCP1, subunit 5 (epsilon) Cct5 0.42 AF075595 Isoprenylcysteine carboxyl methyltransferase Icmt 0.42 AW143008 Solute carrier family 16 (monocarboxylic acid Slc16a6 0.42 transporters), member 6 AA848530 WD repeat domain 12 Wdr12 0.42

NM_012665 Synaptotagmin 2 Syt2 0.42 BG671823 Blocked early in transport 1 homolog (S.cerevisiae) Bet1 0.42 NM_030870 8-oxoguanine DNA-glycosylase 1 Ogg1 0.42 NM_031342 Lysophospholipase 2 Lypla2 0.42 NM_031747 Calponin 1 Cnn1 0.42 0.19 J05035 Steroid 5 alpha-reductase 1 Srd5a1 0.41 NM_031749 Glucosidase 1 Gcs1 0.41 Y11321 Forkhead box E1 (thyroid transcription factor 2) Foxe1 0.41 NM_012796 Glutathione S-transferase, theta 2 Gstt2 0.41 NM_012552 Elastase 1, pancreatic Ela1 0.41 3.22 BF562149 Kruppel-like factor 3 (basic) Klf3 0.41 AW253880 Kinesin family member C1 Kifc1 0.41 BF557572 Fibroblast growth factor receptor 2 Fgfr2 0.41 NM_017200 pathway inhibitor Tfpi 0.41 AA892298 Peptidylprolyl isomerase (cyclophilin)-like 3 Ppil3 0.41 BG669587 Integrin, alpha 6 Itga6 0.40 M36410 Spr 0.40 NM_019339 Regulator of G-protein signaling 12 Rgs12 0.40 NM_017235 Hydroxysteroid (17-beta) dehydrogenase 7 Hsd17b7 0.40 NM_021696 Serine (or cysteine) proteinase inhibitor, B, Serpinb2 0.40 member 2 NM_133591 Rph3al 0.40

AB005052 Huntingtin interacting protein 1 related Hip1r 0.40 NM_019251 Blocked early in transport 1 homolog (S.cerevisiae) Bet1 0.40 AW252087 Heat shock 27kD protein family, member 7 Hspb7 0.39 (cardiovascular) AI103146 Glycogen synthase kinase 3 alpha Gsk3a 0.39

AI008376 Similar to III (RNase III) (p241) (predicted) Etohi2 0.39 NM_031712 PDZ domain containing 1 Pdzk1 0.39 NM_017058 receptor Vdr 0.39 AI411497 Adenylate kinase 2 Ak2 0.39 NM_053917 Inositol polyphosphate-4-phosphatase, type II Inpp4b 0.39 NM_017029 Neurofilament 3, medium Nef3 0.39 NM_017161 Adora2b 0.38 AI234719 Stromal interaction molecule 2 (predicted) Stim2 0.38 NM_031549 Transgelin Tagln 0.38 0.28 BE099224 Steroidogenic acute regulatory protein Star 0.38 NM_019141 -like enhancer of split 4, E(spl) homolog Tle4 0.38 (Drosophila)

35

Downloaded from iovs.arvojournals.org on 09/30/2021 M13506 Liver UDP-glucuronosyltransferase, - Udpgtr2 0.38 inducible form NM_031815 Inhibin beta E Inhbe 0.38

AI410349 Mitochondrial ribosomal protein L16 Mrpl16 0.37 AW921149 Complement component 2 C2 0.37 BF283754 Caspase 7 Casp7 0.37 BG671375 Signal recognition particle 54 kDa Srp54 0.37 AJ245648 Polymerase (DNA directed), alpha 2 Pola2 0.37 AF141863 receptor 1B Mtnr1b 0.37 AI407095 Quinolinate phosphoribosyltransferase (predicted) Qprt 0.36 NM_031832 Lectin, galactose binding, soluble 3 Lgals3 0.36 AF223951 Translocase of inner mitochondrial membrane 22 Timm22 0.36 homolog (yeast) NM_019201 C-terminal binding protein 1 Ctbp1 0.36

AI111840 (predicted) Pmvk 0.36 NM_031716 WNT1 inducible signaling pathway protein 1 Wisp1 0.36 AF192757 6 interacting protein Pdcd6ip 0.35 NM_052809 Cytosolic 1 Cdo1 0.35 BF550847 UDP 1 family, polypeptide A6 Ugt1a6 0.35 M33648 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Hmgcs2 0.35 NM_013198 B Maob 0.34 AI228233 Epsin 2 Epn2 0.34 NM_053919 CEA-related cell adhesion molecule 9 Ceacam9 0.34 NM_017301 Endothelial differentiation sphingolipid G-protein-coupled Edg1 0.34 receptor 1 NM_019296 Cell division cycle 2 homolog A (S. pombe) Cdc2a 0.34

NM_017094 Ghr 0.34 U31203 Noggin Nog 0.34 AI175026 Ubiquitin specific protease 19 Usp19 0.33 NM_130413 Src family associated phosphoprotein 2 Scap2 0.32 NM_012777 Apolipoprotein D Apod 0.32 NM_012774 Glypican 3 Gpc3 0.31 AI233133 Mitchondrial ribosomal protein S7 (predicted) Mrps7 0.31 NM_053526 Carboxypeptidase N, polypeptide 1, 50kD Cpn1 0.31 4.04 NM_019370 Ectonucleotide pyrophosphatase/ Enpp3 0.31 NM_031696 G-protein coupled receptor 88 Gpr88 0.31 NM_133298 Glycoprotein (transmembrane) nmb Gpnmb 0.30 AI138048 critical region gene 1-like 1 Dscr1l1 0.30 NM_031145 Calcium and integrin binding 1 (calmyrin) Cib1 0.29 NM_031585 Phospholipase A2, group IB Pla2g1b 0.29 AW142847 Heat shock factor 2 Hsf2 0.29 NM_133619 Glycoprotein hormone alpha 2 Gpha2 0.29 0.47 NM_012869 receptor Y5 Npy5r 0.28 3.49 AI232565 Activity-dependent neuroprotective protein Adnp 0.28 NM_019298 Cholinergic receptor, nicotinic, delta polypeptide Chrnd 0.28 2.25 NM_053370 Translocase of inner mitochondrial membrane 8 homolog Timm8a 0.28 a (yeast)

36

Downloaded from iovs.arvojournals.org on 09/30/2021 U65656 Matrix metallopeptidase 2 Mmp2 0.27

NM_030871 Phosphodiesterase 1A, calmodulin-dependent Pde1a 0.26 NM_031126 Syntaxin binding protein 2 Stxbp2 0.26 X89963 Thrombospondin 4 Thbs4 0.26 BE111805 Lymphoblastic leukemia derived sequence 1 Lyl1 0.25 NM_019334 Paired-like homeodomain transcription factor 2 Pitx2 0.25 0.42 NM_013178 Sodium channel, voltage-gated, type IV, alpha Scn4a 0.24 polypeptide NM_053977 Cadherin 17 Cdh17 0.24

NM_012855 Jak3 0.22 4.65 NM_017362 Cholinergic receptor, muscarinic 5 Chrm5 0.21 NM_134329 Alcohol dehydrogenase 7 (class IV), mu or sigma Adh7 0.21 0.15 polypeptide NM_030998 Anti-Mullerian hormone type 2 receptor Amhr2 0.20

NM_012799 receptor Nmbr 0.20 AW143803 Hypoxanthine guanine phosphoribosyl transferase Hprt 0.19 AI598486 Dihydropyrimidinase-like 3 Dpysl3 0.19 NM_019292 Carbonic anhydrase 3 Ca3 0.18 U25137 Signal transducer and activator of transcription 5A Stat5a 0.16 NM_013104 Insulin-like growth factor binding protein 6 Igfbp6 0.15 NM_012550 type A Ednra 0.05 2.08 NM_021701 Protein phospatase 3, regulatory subunit B, alpha Ppp3r2 0.03 isoform,type 2 NM_032082 Hydroxyacid oxidase 2 (long chain) Hao2 27.31

NM_130741 Lipocalin 2 Lcn2 7.19 NM_012549 Edn2 5.93 NM_017210 Deiodinase, iodothyronine, type III Dio3 5.69 NM_012794 Glycosylation dependent cell adhesion molecule 1 Glycam1 5.27 NM_013154 CCAAT/enhancer binding protein (C/EBP), delta Cebpd 5.10 AF062402 Chondroitin sulfate proteoglycan 2 Cspg2 5.05 NM_031755 CEA-related cell adhesion molecule 1 Ceacam1 3.94 NM_031817 Osteomodulin Omd 3.52 M33936 Cytochrome P450, family 4, subfamily a, polypeptide 14 Cyp4a14 3.19 U53184 LPS-induced TNF-alpha factor Litaf 3.16

NM_017179 Unc4.1 homeobox (C. elegans) Uncx4.1 3.15 NM_012594 Lactalbumin, alpha Lalba 3.10 AW919132 Rapostlin Fnbp1 3.08 BF285109 Phosphoenolpyruvate carboxykinase 1 Pck1 2.99 NM_133380 receptor Il4r 2.96 NM_012697 Solute carrier family 22 (organic cation transporter), Slc22a1 2.89 member 1 AI012356 Signal transducer and activator of transcription 3 Stat3 2.79

AA955206 -like 2 Fgl2 2.78 NM_013103 Transcription factor 2 Tcf2 2.60

37

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_017082 Uromodulin Umod 2.57 NM_024352 Macrophage stimulating 1 (hepatocyte growth factor-like) Mst1 2.52 NM_138525 Mucin and cadherin like Mucdhl 2.52

M24327 Metallothionein Mt1a 2.52 NM_012909 Aqp2 2.48 NM_012532 Cp 2.47 NM_013091 Tumor necrosis factor receptor superfamily, member 1a Tnfrsf1a 2.46 NM_012579 Hist1h1t 2.44 NM_012669 Transcription factor 1 Tcf1 2.41 NM_017260 Arachidonate 5- activating protein Alox5ap 2.41 U06230 Protein S (alpha) Pros1 2.41 NM_012488 Alpha-2-macroglobulin A2m 2.36 NM_012676 T2, cardiac Tnnt2 2.34 NM_024400 A disintegrin-like and metalloprotease (reprolysin type) Adamts1 2.34 with thrombospondin type 1 motif, 1 AI717113 Coagulation factor 5 F5 2.23

NM_021744 CD14 antigen Cd14 2.22 NM_016994 Complement component 3 C3 2.20 NM_012606 Myosin, light polypeptide 3 Myl3 2.18 NM_012604 Myosin, heavy polypeptide 3, skeletal muscle, embryonic Myh3 2.17 NM_031584 Solute carrier family 22 (organic cation transporter), Slc22a2 2.15 member 2 NM_012630 receptor Prlr 2.13

NM_031564 Eph receptor A3 Epha3 2.11 NM_013115 Ptgfr 2.11 NM_031321 Slit homolog 3 (Drosophila) Slit3 2.07 NM_017062 Reversion induced LIM gene Ril 2.07 AW918564 Phosphoribosyl pyrophosphate synthetase 2 Prps2 2.06 NM_053736 Caspase 11 Casp4 2.06 BF405725 MAS-related GPR, member F Mrgprf 2.04 NM_012971 Potassium voltage-gated channel, shaker-related Kcna4 2.04 subfamily, member 4 NM_013005 Phosphatidylinositol 3-kinase, regulatory subunit, Pik3r1 2.02 polypeptide 1 NM_053416 Double-stranded RNA-binding protein p74 Strbp 0.49

BF523660 Type I KA13 Ka13 0.48 NM_012614 Neuropeptide Y Npy 0.47 NM_053817 Neurexin 3 Nrxn3 0.47 NM_030991 Synaptosomal-associated protein 25 Snap25 0.47 NM_017185 Troponin 1, type 2 Tnni2 0.47 NM_022936 Epoxide hydrolase 2, cytoplasmic Ephx2 0.45 M15797 Nidogen (entactin) Nid 0.44 AF247451 Hyperpolarization activated cyclic nucleotide-gated Hcn2 0.42 potassium channel 2 NM_053883 Dual specificity phosphatase 6 Dusp6 0.42

38

Downloaded from iovs.arvojournals.org on 09/30/2021 NM_012978 /choriogonadotropin receptor Lhcgr 0.42 AF181992 Dynein, cytoplasmic, light intermediate chain 1 Dncli1 0.38 L04684 Calcium channel, voltage-dependent, L type, alpha 1S Cacna1s 0.37 subunit NM_057109 BarH-like 1 (Drosophila) Barhl2 0.36

M25071 Thyroid hormone receptor beta Thrb 0.35 NM_013034 Solute carrier family 6 (neurotransmitter transporter, Slc6a4 0.34 serotonin), member 4 NM_012918 Calcium channel, voltage-dependent, P/Q type, alpha 1A Cacna1a 0.33 subunit NM_053388 Gap junction membrane channel protein beta 6 Gjb6 0.28

AI639157 Dnase1 0.26 NM_024360 Hairy and enhancer of split 1 (Drosophila) Hes1 0.24 NM_138547 3-alpha-hydroxysteroid dehydrogenase LOC1915 0.23 74 AA891826 Tumor-associated calcium signal transducer 2 Tacstd2 0.21 X59859 Decorin Dcn 0.20 AB003104 Beaded filament structural protein 1 Bfsp1 0.17 NM_012779 Aquaporin 5 Aqp5 0.13 NM_017365 PDZ and LIM domain 1 (elfin) Pdlim1 0.12 BE109730 Mbp 0.09 NM_031972 Aldehyde dehydrogenase family 3, member A1 Aldh3a1 0.07

39

Downloaded from iovs.arvojournals.org on 09/30/2021