Supplementary Material
Dose regimen rationale for panitumumab in cancer patients: to be based on body weight or not
Michael Z. Liao, Marloes Berkhout, Hans Prenen, Sandeep Dutta, Vijay V. Upreti Supplemental Table S1. Overview of study sites and institutional review boards granting study approval for the studies included in this analysis
Clinical Trial Study Site Study Site (Location) Institutional Review Board (Location) Number NCT00089635a 0012 5841 S Maryland Ave Mc 2115 (Chicago, IL, US) University of Chicago, Institutional Review Board (Chicago, IL, US) 777 Preston Research Building (Nashville, 0086 Vanderbilt University, Institutional Review Board (Nashville, TN, US) TN,US) 4301 W Markham Mail Slot 508 (Little Rock, AR, University of Arkansas for Medical Sciences Institutional Review Board (Little 0120 US) Rock, AR, US) 0908 4101 22nd Place (Lubbock, TX, US) Covenant Health System Institutional Review Board (Lubbock, TX, US) 1801 SE Hillmoor Drive, Suite B-101 (Port St. 0909 Western Institutional Review Board (Olympia, WA, US) Lucie, FL, US) 11185 Mountain View Avenue Suite 151 (Loma 0910 Loma Linda University (Loma Linda, CA, US) Linda, CA, US) 1009 200 Hawthorne Lane (Charlotte, NC, US) Presbyterian Healthcare Institutional Review Board (Charlotte, NC, US) 745 West State Street Suite 550B (Columbus, 1010 Mount Carmel Institutional Review Board (Columbus, OH, US) OH, US) 1016 910 E. Houston Street, Suite 100 (Tyler, TX, US) US Oncology, Inc. Institutional Review Board (Dallas, TX, US) 1019 169 Riverside Drive (Binghamton, NY, US) Western Institutional Review Board (Olympia, WA, US) 1027 300 W Pueblo Street (Santa Barbara, CA, US) Western Institutional Review Board (Olympia, WA, US) Thomas and Dorothy Leavey Cancer Center 1040 Western Institutional Review Board (Olympia, WA, US) (Northridge, CA, US) 920 Stanton L Young Blvd. WP 2080, Dept. of 1063 University of Oklahoma Health Science Center (Oklahoma City, OK, US) Hematology/Oncology (Oklahoma City, OK, US) 1068 8940 North Wood Sage Road (Peoria, IL, US) Western Institutional Review Board (Olympia, WA, US) 1078 4801 East Linwood Blvd (Kansas City, MO, US) KVAMC (Kansas City, MO, US) 1082 1800 Williams Street Suite 200 (Denver, CO, US) Western Institutional Review Board (Olympia, WA, US) 16 Penn Tower 3400 Spruce Street Committee on Studies Involving Human Beings, Office of Regulatory Affairs 1086 (Philadelphia, PA, US) (Philadelphia, PA, US) 330 Washington Street, Suite 220 (Norwich, CT, 1087 The William W. Backus Hospital (Norwich, CT, US) US) 1025 Walnut Street Suite 1014 (Philadelphia, PA, 1090 Thomas Jefferson University Institutional Review Board (Philadelphia, PA, US) US) 1092 2825 8th Avenue North (Billings, MT, US) Quorum Review, Inc. (Seattle, WA, US) 1096 9711 Skokie Boulevard (Skokie, IL, US) Western Institutional Review Board (Olympia, WA, US) 1100 1348 Walton Way, Suite 4300 (Augusta, GA, US) Western Institutional Review Board (Olympia, WA, US) 95 Collier Road NW, Suite 5015 (Atlanta, GA, 1104 Quorum Review, Inc. (Seattle, WA, US) US) 1113 302 Kensington Avenue (Flint, MI, US) Quorum Review, Inc. (Seattle, WA, US) 1114 8111 South Emerson (Indianapolis, IN, US) Western Institutional Review Board (Olympia, WA, US) 1115 34 Shelburne Road (Stamford, CT, US) Western Institutional Review Board (Olympia, WA, US) 9143 Phillips Highway, Suite 560 (Jacksonville, 1119 Western Institutional Review Board (Olympia, WA, US) FL, US) 1122 3838 S. 700 East, #100 (Salt Lake City, UT, US) Western Institutional Review Board (Olympia, WA, US) 1123 1700 South Potomac St (Aurora, CO, US) Western Institutional Review Board (Olympia, WA, US) 1124 3027 N Circle Drive (Colorado Springs, CO, US) Western Institutional Review Board (Olympia, WA, US) 1125 22 W Dry Creek Circle (Littleton, CO, US) Western Institutional Review Board (Olympia, WA, US) Joan Karnell Cancer Center (Philadelphia, 1132 Pennsylvania Hospital Institutional Review Board (Philadelphia, PA, US) PA,US) 1144 600 East 233rd Street (Bronx, NY, US) Our Lady of Mercy Medical Center Institutional Review Board (Bronx, NY, US) 1150 399 Melrose Drive, Suite B (Richardson, TX, US) Quorum Review, Inc. (Seattle, WA, US) 1152 490-A West Zia Road (Sante Fe, NM, US) Quorum Review, Inc. (Seattle, WA, US) 100 North Humphreys Boulevard, Suite 100 1156 Western Institutional Review Board (Olympia, WA, US) (Memphis, TN, US) 1075 Chase Parkway Street Suite # B 1157 Quorum Review, Inc. (Seattle, WA, US) (Waterbury, CT, US) 18051 River Road, Suite 201 (Noblesville, IN, 1159 Western Institutional Review Board (Olympia, WA, US) US) 4403 Harrison Boulevard, Suite 1685 (Ogden, 1160 Western Institutional Review Board (Olympia, WA, US) UT, US) 1161 1001 12th Avenue (Fort Worth, TX, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, USA) 1162 520 Country Club Road (Eugene, OR, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1165 1346 E County Line Road (Indianapolis, IN, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1166 433 SW 10th Street (Ocala, FL, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1167 3555 W Wheatland (Dallas, TX, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1174 69 Prospect Avenue (Hudson, NY, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 317 S Manning Boulevard Suite 310 (Albany, NY, 1192 US Oncology, Inc., Institutional Review Board (Dallas, TX, US) US) 4320 Wornall Road Suites 212 & 220 (Kansas 1216 US Oncology, Inc., Institutional Review Board (Dallas, TX, US) City, MO, US) 4881 NE Goodview Circle (Lee’s Summit, MO, 1217 US Oncology, Inc., Institutional Review Board (Dallas, TX, US) US) 1228 8503 Arlington Blvd., Suite 400 (Fairfax, VA, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1232 6204 Balcones Drive (Austin, TX, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1242 59-16 174th Street (Fresh Meadows, NY, US) Quorum Review, Inc.(Seattle, WA, US) 44105 15th Street West, Suite 207 (Lancaster, 1244 Quorum Review, Inc.(Seattle, WA, US) CA, US) 25 Hospital Center Boulevard, Medical Pavillion 1245 Quorum Review, Inc.(Seattle, WA, US) Suite 301 (Hilton Head, SC, US) 9110 Philadelphia Road, #314 (Baltimore, MD, 1247 Quorum Review, Inc.(Seattle, WA, US) US) 3320 Old Jefferson Road Building 700 (Athens, 1252 Western Institutional Review Board (Olympia, WA, US) GA, US) 1257 225 18th Street Southeast (Hickory, NC, US) US Oncology, Inc., Institutional Review Board (Dallas, TX, US) 1270 100 East Idaho Street (Boise, ID, US) St. Luke’s Institutional Review Board (Boise, ID, US) 1930 East Route 70, Suite V107 (Cherry Hill, NJ, 1275 Quorum Review, Inc.(Seattle, WA, US) US) 1288 1313 Red River, Suite 217 (Austin, TX, US) Quorum Review, Inc.(Seattle, WA, US) NCT00083616a 0012 University of Chicago (Chicago, IL, US) University of Chicago (Chicago, IL US) 0086 Vanderbilt University (Nashville, TN, US) Vanderbilt University (Nashville, TN, US) University of Texas – Southwestern (Dallas, TX, 0361 UT Southwestern Medical Center at Dallas (Dallas, TX, US) US) Joe Arrington Cancer Research and Treatment 0908 Covenant Health System IRB (Lubbock, TX, US) Center (Lubbock, TX) Hematology Oncology Associates of Treasure 0909 Western Institutional Review Board (Olympia, WA, US) Coast (Port St. Lucie, FL, US) 0910 Loma Linda University (Loma Linda, CA, US) Loma Linda University (Loma Linda, CA, US) Comprehensive Blood and Cancer Center 1011 Western Institutional Review Board (Olympia, WA, US) (Bakersfield, CA, US) Comprehensive Cancer Centers of Nevada (Las 1017 Western Institutional Review Board (Olympia, WA, US) Vegas, NV, US) 1019 Broome Oncology, LLC (Binghamton, NY, US) Western Institutional Review Board (Olympia, WA, US) 1023 MD Anderson Cancer Center (Houston, TX, US) University of Texas MD Anderson Cancer Center (Houston, TX, US) Santa Barbara Hematology Oncology Group, Inc. 1027 Western Institutional Review Board (Olympia, WA, US) (Santa Barbara, CA, US) California Oncology of the Central Valley 1035 Western Institutional Review Board (Olympia, WA, US) (Fresno, CA, US) Comprehensive Cancer Centers of Nevada – Comprehensive Cancer Centers of Nevada – Henderson (Henderson, NV, 1042 Henderson (Henderson, NV, US) US) Pacific Shores Medical Group – Long Beach 1043 Western Institutional Review Board (Olympia, WA, US) (Long Beach, CA, US) Central Hematology Oncology Group (Monterey 1044 Western Institutional Review Board (Olympia, WA, US) Park, CA, US) Sansum Santa Barbara Medical Foundation 1047 Western Institutional Review Board (Olympia, WA, US) Clinic (Santa Barbara, CA, US) Mid-Ohio Oncology Hematology Inc –West 1051 Mount Carmel Institutional Review Board (Columbus, OH, US) (Columbus, OH, US) University of Oklahoma Health Sciences Center 1063 University of Oklahoma Health Science Center (Oklahoma City, OK, US) (Oklahoma City, OK, US) Rocky Mountain Cancer Centers (Denver, CO, 1082 Western Institutional Review Board (Olympia, WA, US) US) 1083 N/A Dean Foundation for Health Research & Education (Middleton, WI, US) University of Pennsylvania Cancer Center 1086 University of Pennsylvania (Philadelphia, PA, US) (Philadelphia, PA, US) 1088 Nebraska Methodist Hospital (Omaha, NE, US) Nebraska Methodist Hospital (Omaha, NE, US) Thomas Jefferson University (Philadelphia, PA, 1090 Thomas Jefferson University (Philadelphia, PA, US) US) 1092 Deaconess Billings Clinic (Billings, MT, US) Quorum Review, Inc. (Seattle, WA, US) University of Southern California/Norris 1095 Comprehensive Cancer Center (Los Angeles, Western Institutional Review Board (Olympia, WA, US) CA, US) Augusta Oncology Associates, PC Walton 1100 Western Institutional Review Board (Olympia, WA, US) (Augusta, GA, US) 1103 The Family Practice Center (Collierville, TN, US) Western Institutional Review Board (Olympia, WA, US) 1108 Midwest Cancer Research (Chicago, IL, US) Western Institutional Review Board (Olympia, WA, US) Genesys Hurley Cancer Institute, Cancer and 1113 Quorum Review, Inc. (Seattle, WA, US) Blood Disease Treatment Center (Flint, MI, US) 1115 Hematology Oncology PC (Stamford, CT, US) Western Institutional Review Board (Olympia, WA, US) 1122 Utah Cancer Specialists (Salt Lake City, UT, US) Western Institutional Review Board (Olympia, WA, US) Rocky Mountain Cancer Centers – Colorado 1124 Western Institutional Review Board (Olympia, WA, US) Springs (Colorado Springs, CO, US) Rocky Mountain Cancer Centers – Boulder 1126 Western Institutional Review Board (Olympia, WA, US) (Boulder, CO, US) Montgomery Cancer Center (Montgomery, AL, 1128 Quorum Review, Inc. (Seattle, WA, US) US) Pennsylvania Hematology Oncology Associates 1132 N/A (Philadelphia, PA, US) University of North Carolina – Chapel Hill, Div Of 1135 University of North Carolina at Chapel Hill (Chapel Hill, NC, US) Medical Oncology (Chapel Hill, NC, US) Drs. Sandenbaum and Joseph Associates, Inc. 1147 Western Institutional Review Board (Olympia, WA, US) (Cranston, RI, US) 1149 NYU Medical School (New York, NY, US) BRANY Institutional Review Board (Great Neck, NY, US) New Mexico Cancer Associates (Sante Fe, NM, 1152 Quorum Review, Inc. (Seattle, WA, US) US) 1155 Gabrail Cancer Center (Canton, OH, US) Western Institutional Review Board (Olympia, WA, US) Willamette Valley Cancer Center – Eugene 1162 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) (Eugene, OR, US) Cavell Cancer Treatment Program (Hudson, NY, 1174 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) US) Texas Oncology PA – Sammons Cancer Center 1179 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) (Dallas, TX, US) Willamette Valley Cancer Center – Springfield 1180 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) (Springfield, OR, US) Arch Medical Services, Inc. (Washington, MO, 1185 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) US) Minnesota Oncology Hematology –Maplewood 1188 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) (Maplewood, MN, US) Hematology Oncology Physicians – SMO 1212 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) (Tucson, AZ, US) Kansas City Cancer Centers – North (Kansas 1214 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) City, MO, US) Kansas City Cancer Centers – South (Kansas 1215 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) City, MO, US) The Don and Sybil Harrington Cancer Center 1218 Western Institutional Review Board (Olympia, WA, US) (Amarillo, TX, US) Kansas City Cancer Centers, LLC (Overland 1219 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) Park, KS, US) Oncology and Hematology Associates of 1224 US Oncology, Inc. Institutional Review Board (Dallas, TX, US) Southwest Virginia (Salem, VA, US) 1226 N/A US Oncology, Inc. Institutional Review Board (Dallas, TX, US) 1228 N/A US Oncology, Inc. Institutional Review Board (Dallas, TX, US) 1232 Texas Oncology Cancer Center (Austin, TX, US) US Oncology, Inc. Institutional Review Board (Dallas, TX, US) Antelope Valley Cancer Center (Lancaster, CA, 1244 Quorum Review, Inc. (Seattle, WA, US) US) Gainesville Hematology Oncology Associates 1280 Quorum Review, Inc. (Seattle, WA, US) (Gainesville, FL, US) 1281 N/A Western Institutional Review Board (Olympia, WA, US) 1282 N/A Western Institutional Review Board (Olympia, WA, US) 1283 N/A Western Institutional Review Board (Olympia, WA, US) 1285 N/A Quorum Review, Inc. (Seattle, WA, US) 1288 N/A Quorum Review, Inc. (Seattle, WA, US) NCT00113763a Universitätsklinik für Innere Medizin I, Abteilung 1001 Ethikkommission des AKH und der Universitätskliniken Wien (Wien, Austria) für OnkologieI (Wien, Austria) Ethikkommission des A.ö. KH der Barmherzigen Schwestern, vom Heiligen 1002 Aö KH Wels, 4. Interne Abteilung (Wels, Austria) Kreuz (Wels, Austria) Kaiser-Franz Josef-Spital, LBI für angewandte 1003 Krebsforschung an der 3. Medizinischen Ethikkimmission der Stadt Wien (Wien, Austria) Abteilung (Wien, Austria) Universitätsklinik für Innere Medizin (Innsbruck, Ethikkommission der Medizinischen Fakultät der Universität Innsbruck 1004 Austria) (Innsbruck, Austria) UZ Gasthuisberg, Gastro-Enterology Department Faculty of Medecine Medical Ethics Committee/Clinical Trials (Leuven, 1101 (Leuven, Belgium) Belgium) Institut J. Bordet, Gastro-Entérology Department 1102 Comité d’ Ethique, Institut J. Bordet (Brussels, Belgium) (Brussels, Belgium) UZ Gent, Gastro-Enterology Department (Gent, 1103 Ethical Committee, UZ Gent (Gent, Belgium) Belgium) UCL St. Luc - Centre des Tumeurs,Oncologie Commission d’Ethique Biomédicale Hopitalo-Facultaire de l’UCL (Brussels, 1104 Clinique (Brussels, Belgium) Belgium) C.H. Notre Dame et Reine Fabiola, Onco- 1105 Ethical Committee, C.H. Notre Dame et Reine Fabiola (Charleroi, Belgium) Hematology Department (Charleroi, Belgium) 1106 AZ VUB, Oncologic Center (Brussels, Belgium) Ethical Committee, AZ VUB (Brussels, Belgium) Hôpital Erasme, Gastro-Enterology Department 1107 Comité d’Ethique, Hôpital Erasme (Brussels, Belgium) (Brussels, Belgium) Hépato-gastro-entérologie, Institut Arnault C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (REIMS, 1201 Tzanck (Saint Laurent du Var, France) France) 1202 Hôpital Tenon (Paris, France) C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (Reims, France) Hôpital Saint-Joseph, Service d’Hépato-gastro- 1203 C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (Reims, France) entérologie (Marselle, France) CHU de Reims – Hôpital Robert Debré, Comité Consultatif de Protection des Perdonnes dans la Recherche 1205 Département d’Hépato-gastr-entérologie / Biomédicale de Champagne-Ardenne, Hôpital Maison Blanche (Reims, oncologie digestive (Reims, France) France) 1208 Hôpital Ambroise Paré (Boulogne, France) C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (Reims, France) 1209 Clinique Sainte Catherine (Avignon, France) C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (Reims, France) Hôpital Lévêque, Service d’Hépato- 1211 C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (Reims, France) gastrentérologie (Pessac, France) Département de Médecine – Oncologie Médicale 1212 C.C.P.R.B. de Champagne-Ardenne, Hôpital Maison Blanche (Reims, France) 1, Institut Paoli-Calmettes (Marseille, France Central: Ethik-Kommission der Bayerischen Landesärztekammer (München, Westpfalz Klinikum GmbH, Medizinishce Klinik I, Germany) 1303 Innere Medizin (Kaiserslautern, Germany) Local: Landesärztekammer Rheinland-Pfalz, Ethikkommission (Mainz, Germany) Krankenhaus der Barmherzigen Brüder 1304 Medizinische Klinik IV, Internistische Ethik-Kommission der Bayerischen Landesärztekammer (München, Germany) Onkologie/Hämatologie (Regensburg, Germany) Klinik für Innere Medizin II, Klinikum der Stadt Central: Ethik-Kommission der Bayerischen Landesärztekammer (München, 1306 Villingen-Schwenningen (Villingen- Germany) Schwenningen, Germany) Local: Ethik-Kommission der Albert-Ludwigs-Universität Freiburg (Freiburg, Germany) Central: Ethik-Kommission der Bayerischen Landesärztekammer (München, DIAKO, Ev. Diakonie-Krankenhaus GmbH, Germany) 1309 Abteilung Hämatologie/Internistische Onkologie Local: Ethikkommission der Landesärztekammer Bremen, Institut für Klinische (Bremen, Germany) Pharmakologie (Bremen, Germany) Gemeinschaftspraxis, Hämatologen – 1312 Bayerische Landersarztekammer, Ethikkommission (München, Germany) Internistische Onkologen (Rehling, Germany) Central: Ethik-Kommission der Bayerischen Landesärztekammer (München, Caritasklinik St. Theresia, Klinik für Hämatologie Germany) 1313 und Onkologie (Saarbrücken, Germany) Local: Ärztekammer des Saarlandes, Ethikkommission (Saarbrücken, Germany) Ospedale Niguarda Ca’ Granda, P.zza Ospedale 1401 Comitato etico scientifico, Ospedale Niguarda Ca’ Granda (Milano, Italy) Maggiore 3 (Milano, Italy) 1402 A.O. San Camillo Forlanini (Roma Italy) Secretaria Comitato Etico, Farmacia Ospedale S. Camillo (Roma, Italy) Azienda Ospedaliera Umberto I, Sede Torrette 1403 Comitato Etico, Azienda Ospedaliera Umberto I (Ancona, Italy) (Ancona, Italy) Instituto Clinico Humanitas, Department of Comitato Etico, Azienda Sanitaria Locale della Provincia di Milano 2 (Milan, 1404 Medical Oncology and Hematology (Milan, Italy) Italy) U.O. Oncologia Medica – Centro Oncologico, 1405 Modenese COM, Policlinico di Modena (Modena, Comitato Etico Provinciale di Modena, Policlinico di Modena (Modena, Italy) Italy) Dipartimento di Oncologia Medica, Azienda Comitato Etico, Azienda Ospedaliera San Martino e Cliniche Universitarie 1406 Ospedaliera San Martino (Genova, Italy) Convenzionate (Genova, Italy) Istituto per lo Studio a la Cura dei Tomori 1408 Comitato Etico, Istituto per lo Studio e la Cura dei Tumori (Milano, Italy) (Milano, Italy) Policlinico Umberto I, Università La Sapienza 1409 Comitato Etico, Azienda Policlinico Umberto I di Roma (Roma, Italy) (Roma, Italy) I.R.C.C.S. Ospedale Oncologico – di Bari (Bari, 1410 Comitato Etico, I.R.C.C.S. Ospedale Oncologico – di Bari (Bari, Italy) Italy) Istituti Fisioterapici Ospitalieri (IFO) - IRCCS Segreterio Comitato Etico, IRCCSS Regina Elena – IRCCSS San Gallicano 1411 Regina Elena (Roma, Italy) (Roma, Italy) Department Medical Oncology, Catholic 1412 Comitato Etico, Catholic University – Policlinico Gemelli (Roma, Italy) University (Roma, Italy) Universitair Medisch Centrum Utrecht, (Utrecht, Ethics Committee of the Universitair Medisch Centrum Utrecht (Utrecht, The 1502 The Netherlands) Netherlands) Stichting Therapeutische Evaluatie Geneesmiddelen (Duivendrecht, The Netherlands) Ethics Committee of the Albert Schweitzer Ziekenhuis (Dordrecht, The Albert-Schweitzer Ziekenhuis, (Dordrecht, The Netherlands) 1504 Netherlands) Stichting Therapeutische Evaluatie Geneesmiddelen (Duivendrecht, The Netherlands) Ethics Committee of the St. Ziekenhuis Lievensberg (Bergen op Zoom, The St. Ziekenhuis Lievensberg (Bergen op Zoom, Netherlands) 1505 The Netherlands) Stichting Therapeutische Evaluatie Geneesmiddelen (Duivendrecht, The Netherlands) Instituto Português de Oncologia Francisco Comissão de Ético do Instituto Português de Oncologia Francisco Gentil, 1601 Gentil, Centro Regional de Oncologia de Lisboa, Centro Regional de Oncologia de Lisboa, SA (Lisboa, Portugal) SA (Lisboa, Portugal) Instituto Português de Oncologia Francisco Instituto Português de Oncologia Francisco Gentil, Centro Regional de 1602 Gentil, Centro Regional de Oncologia do Porto, Oncologia do Porto, SA, Serviço de Oncologia II (Porto, Portugal) SA, Serviço de Oncologia II (Porto, Portugal) Hospital Santo António dos Capuchos – Medicina Comissão de Ética do Hospital Santo António dos Capuchos, Alameda Sto. 1603 1 (Lisboa, Portugal) António dos Capuchos (Lisboa, Portugal) 1604 Hospital de Santa Maria (Lisboa, Portugal) Comissão de Ética do Hospital de Santa Maria (Lisboa, Portugal) Instituto Portugués de Oncologia Francisco Comissão de Ética do Instituto Português de Oncologia Francisco Gentil, 1606 Gentil, Centro Regional de Oncologia de Centro Regional de Oncologia de Coimbra, S.A. (Coimbra, Portugal) Coimbra, S.A. (Coimbra, Portugal) Hospital Clínico San Carlos Comité Etico de Investigación Clínico (Madrid, Hospital Clínico San Carlos, Servicio de 1701 Spain) Oncología Médica (Madrid, Spain) Agencia Española del Medicamento (Madrid, Spain) Hospital Clínico Universitario de Valencia, Clinical Research Ethics Committee,Hospital Clínico Universitario de Valencia 1702 Oncology-Hematology Department (Valencia, (Valencia, Spain) Spain) Agencia Española del Medicamento (Madrid, Spain) Hospital 12 de Octubre, Oncology Department Comité Ético de Investigación Clínica, Hospital 12 de Octubre (Madrid, Spain) 1703 (Madrid, Spain) Agencia Española del Medicamento (Madrid, Spain) Comité ético de Investigación Clínica, Hospital General de Alicante (Alicante, Hospital General de Alicante, Oncology 1704 Spain) Department (Alicante, Spain) Agencia Española del Medicamento (Madrid, Spain) Comité Ético de Investigación Clínica Oncology Department, Hospital General de Elche 1705 Hospital General de Elche (Elche, Spain) (Elche, Spain) Agencia Española del Medicamento (Madrid, Spain) Hospital Carlos Haya, Comité Etico de Investigación Clínica (Malaga, Spain) Hospital Carlos Haya, Servicio de Oncología 1707 Hospital Germans Trias I Pujol Médica (Malaga, Spain) Carretera del Canyet (Barcelona, Spain) Clinical Research Ethics Committee, Hospital Clínic I Provincial de Barcelona Hospital Clínic I Provincial de Barcelona, 1708 (Barcelona, Spain) Oncology Department (Barcelona, Spain) Agencia Española del Medicamento (Madrid, Spain) Clinical Research Ethics Committee, Hospital Vall d’Hebrón (Barcelona, Hospital Vall d’Hebrón, Oncology Department 1709 Spain) (Barcelona, Spain) Agencia Española del Medicamento (Madrid, Spain) Kantonspital St. Gallen, Haus 01, Fachbereich Ethikkommission des Kantons St. Gallen, Kantonsspital St. Gallen (St Gallen, 1803 Onkologie (St Gallen, Switzerland) Switzerland) Institut für Medizinische Onkologie, Inselspital 1804 Kantonale Ethikkommission Bern (Bern, Switzerland) (Bern, Switzerland) SUKL (Praha, Czech Republic) Masarykuv onkologicky ustav (Brno, Czech 3004 Multicentricka eticka komise FN Motol (Praha, Czech Republic) Republic) Eticka komise Masarykuv onkologicky ustav (Brno, Czech Republic) Nemocnice Chomutov, Onkologicke Centrum Multicentricka eticka komise FN Motol (Praha, Czech Republic) 3005 (Chomutov, Czech Republic) Eticka komise Nemocnice Chomutov (Chomutov, Czech Republic) T.Y.P.E.T. Hygeias Melathron Clinic, Oncology 3101 Administrative Board, T.Y.P.E.T. Hygeias Meathron Clinic (Athens, Greece) Department (Athens, Greece) University Hospital of Patras, Internal Medicine Committee of Ethics & Deontology Scientific Board, University Hospital of 3104 Oncology Department (Patras, Greece) Patras (Patras, Greece) Vas County Markusovszky Hospital Vas County Markusovszky Hospital Regional Ethics Committee 3201 (Markusovszky, Hungary) (Markusovszky, Hungary) Petz Aladár County Hospital (Gyor Zrinyi, Gyor-Moson-Sopron Esztergom-Komárom County Research Ethics 3202 Hungary) Committee (Gyor, Hungary) 3206 Szent László Hospital (Budapest, Hungary) Szent László Hospital Ethics Committee (Budapest, Hungary) National Institute of Oncology (Budapest, National Institute of Oncology Institutional Research Ethics Committee 3208 Hungary) (Budapest, Hungary Regulatory Authorities (Bratislava, Slovakia) 3402 National Cancer Institute (Bratislava, Slovakia) Ethics Committee of National Cancer Institute (Bratislava, Slovakia) Oncology Institute of St. Alzbeta (Bratislava, Regulatory Authorities (Bratislava, Slovakia) 3403 Slovakia) Ethics Committee of Oncology Institute of St. Alzbeta (Bratislava, Slovakia) Illawara Area Health Service Wollongong University of Wollongong Illawarra Area Health Service Office of Research 4001 Hospital (Wollongong, NSW, Australia) (North Wollongong, NSW, Australia) Mater Misercordiae Adult Hospital (South Mater Health Services Human Research Ethics Committee (South Brisbane, 4002 Brisbane, QLD, Australia) QLD, Australia) Border Medical Oncology (Wodonga, VIC, 4003 Joint Hospital Ethics Committee (Albury, NSW, Australia) Australia) Peninsula Health Research and Ethics Committee, Frankston Hospital 4004 Frankston Hospital (Frankston, VIC, Australia) (Frankston, VIC, Australia) Medical Oncologist Western Hospital (Footscray, Melbourne Health Research Directorate Clinical Research Ethics Committee 4005 VIC, Australia) (Parkville, VIC, Australia) Wesley Medical Centre (Auchenflower QLD, Wesley Hospital Multidisciplinary Ethics Committee, Wesley Medical Centre 4006 Australia) (Auchenflower QLD, Australia) Adelaide Community Health Care Alliance Inc., Research and Ethics 4007 Ashford Cancer Centre (Ashford, SA, Australia) Committee (Ashford, SA, Australia) Clinical Trials Centre, Mount Hospital (West 4008 Mount Hospital Ethics Committee (West Perth, WA, Australia) Perth, WA, Australia) Medical and Health Sciences, University of Auckland Ethics Committee (Auckland, New Zealand) 4010 Auckland (Auckland, New Zealand) Waikato Ethics Committee (Hamilton, New Zealand) Oncology Department, Waikato Hospital 4011 Northern Y Regional Ethics Committee (Hamilton, New Zealand) (Hamilton, New Zealand) Cabrini Hospital, Medical Oncology (Malvern, 4012 Cabrini Human Research Ethics Committee (Malvern, VIC, Australia) VIC, Australia) 5001 11, Côte du Palais (Québec, Canada) Comité d’éthique de la recherché, Hôtel-Dieu de Québec (Québec, Canada) Department of Medical Oncology, William Osler William Osler Health Care Research Ethics Committee (Brampton, Ontario, 5003 Health Centre, Brampton Memorial Hospital Canada) Campus (Brampton, Ontario, Canada) 969 Queen Street East (Sault Ste. Marie, 5004 Sault Area Hospital – Plummer Site East (Sault Ste. Marie, Ontario, Canada) Ontario, Canada) Humber River Regional Hospital Church St. Site 5006 Humber River Regional Hospital Church St. Site (Weston, Ontario, Canada) (Weston, Ontario, Canada) 5007 596 Davis Drive (Newmarket, Ontario, Canada) Southlake Regional Health Centre (Newmarket, Ontario, Canada) Trillium Health Centre, Oncology Clinic Research Review Team, Trillium Health Centre (Mississauga, Ontario, 5008 (Mississauga, Ontario, Canada) Canada) N/A, not available. aClinical trials registered under ClinicalTrials.gov.