Ole Hyldegaard, MD, Ph.D, DMSci. Consultant in Anaesthesia Medical Director of Hyperbaric Medicine - Rigshospitalet Clinical Research Associate Professor – University of Copenhagen.

Ole Hyldegaard is a Consultant in Anaesthesiology and is Medical Director at the Hyperbaric Medicine Unit of the University Hospital of Copenhagen, Rigshospitalet. An HBO multichamber facility. Appointed Clinical Research Associate Professor at the Medical Faculty, University of Copenhagen. Have a Ph.D. and a doctoral medical science degree in diving medicine on oxygen and inert breathing gas effects on bubbles during hypo- normo and hyperbaric conditions. More than 60 publications as peer-review, proceedings-, book chapters and abstracts in diving- and hyperbaric medicine. Peer-review assignments on several scientific journals including JDHM and JUHM. An over two decades EUBS member (presented first paper in 1989, Palermo, Italy). Former EUBS member-at-large. Secretary General of the annual EUBS scientific meeting in Copenhagen 2003. Certified and government approved, diving medical physician equivalent to EDTC level IIa and certified clinical hyperbaric physician. Course director on several diving medicine courses. Is a diving medical officer in Divers Alert Network hotline services since 1995 and director of DAN Europe Scandinavian local office. Is a recreational CMAS 3-star diver and former CMAS scuba diving instructor.

Significant publications: 1: Hyldegaard,O. & Madsen, J.: Influence of heliox, oxygen and N2O-O2 breathing on N2 bubbles in adipose tissue. Undersea Biomedical Research 1989, vol. 16 (3);185 -193. 2: Hyldegaard,O., Møller, M. & Madsen, J: Effect of heliox, oxygen and N2O-O2 breathing on injected bubbles in spinal white matter. Undersea Biomedical Research,1991, Vol. 18 (5-6);361- 371. 3: Hyldegaard,O., Møller, M. and Madsen, J.: Protective effect of heliox and oxygen breathing during development of spinal decompression sickness. Undersea & Hyperbaric Medicine 1994,21(2);115-128. 4: Madsen, J., Hink, J. and Hyldegaard, O.: Diving Physiology and patophysiology. A review. In Clincal Physiology, 1994, 14;597-626. 5: Hyldegaard,O. and Madsen, J.: Effect of Air, Heliox and Oxygen breathing on air bubbles in Aqueous tissues in the rat. Undersea & Hyperbaric Medicine, 1994, 21(4);413-424. 6: Hyldegaard,O. and Madsen, J.: Effect of SF6-O2 (80/20) breathing on air bubbles in rat tissues. Undersea & Hyperbaric medicine,1995,22(4); 355-365. 7: Hyldegaard,O.: Volume changes of nitrogen and helium bubbles in adipose tissue during air, heliox or oxygen breathing. A Ph.D-Thesis. 75 pages. Department of Medical Physiology, University of Copenhagen, The Panum Institute, Denmark, The Panum Institute Library, febr. 6.th, 1998. 8: Hyldegaard, O., Kerem, D. and Melamed, Y.: Effect of combined recompression and air, oxygen, or heliox breathing on air bubbles in rat tissues. J appl Physiol, 90:1639 -1647, 2001. 9: Hyldegaard, O., Jensen, T.: Effect of heliox, oxygen and air breathing on helium bubbles after heliox diving. Undersea and Hyperbaric Medicine;34(2):107-122, 2007. 10: Hyldegaard, O. and Madsen J.: Effect of hypobaric air, oxygen, heliox(50:50) or heliox(80:20) breathing on air bubbles in adipose tissue. J Appl Physiol, 103: 757 -762, 2007. 11. Randsøe, T., Kvist, T. and Hyldegaard, O.: Effect of oxygen and heliox breathing on air bubbles in adipose tissue during 25 KPA altitude exposures. J Appl Physiol, 105:1492 -1497, 2008. 12. Randsøe, T, Hyldegaard, O. Effect of oxygen breathing and perflurocarbon elmulsion treatment on air bubbles in adipose tissue during decompression sickness. J Appl Physiol;107(6):1857 -63, 2009. 13. Lawson-Smith P., Jansen EC, Hilsted, L. and Hyldegaard O. Effect of Hyperbaric Oxygen Therapy on whole blood CN concentrations in CO intoxicated patients from fire accidents. Scand J Trauma Resusc Emerg Med 2010,15;18:32. 14. Knudsen J, Nauntofte B, Josipovic M, Engelholm SA, Hyldegaard O. Effects of Isoflurane Anesthesia and Pilocarpine on Rat Parotid Saliva Flow. Radiat Res, Jul;176(1):84-8, 2011 15. Hyldegaard O, Kerem D, Melamed Y. Effect of isobaric breathing gas shift from air to heliox mixtures on resolution of air bubbles in lipid and aqeuous tissues of recompressed rats. Eur J Appl Physiol:111(9):2183-2193,2011. 16. Lawson-Smith P, Jansen EC, Hyldegaard O. Cyanide intoxication as part of smoke inhalation – a review on diagnosis and treatment from the emergency perspective. Scand J Trauma Resusc Emerg Med. 3;19:14, 2011. 17. Lawson-Smith P., Jansen EC, Hilsted L., Johnsen AH, and Hyldegaard O. Effect of acute and delayed Hyperbaric Oxygen Therapy on Cyanide whole Blood Levels during acute Cyanide Intoxication. Undersea Hyperbaric Med. 38(1):17-26, 2011. 18. Cronjé FJ, Meintjes WA, Bennett PB, Fitchat S, Marroni A, Hyldegaard O. Analysis of clinical outcomes of linear vs. deep stop decompression from 3.5 to 6 atmospheres absolute (350-600 kPa) in awake rats. Undersea Hyperb Med, 38(1):17-26, 2011. 19. Forner L, Hyldegaard O, von Brockdorff AS, Specht L, Andersen E, Jansen EC, Hill erup S, Nauntofte B, Jensen SB. Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients ? A pilot study. Oral Oncol;47(6):546-51, 2011. 20. Lawson-Smith P, Olsen NV, and Hyldegaard, O. Hyperbaric oxygen therapy or hydroxycobalamin attenuate surges in brain interstitial lactate and glucose and hyperbaric oxygen improve respiratory status in cyanide-intoxicated rats. Undersea Hyperb Med;34(4):223-237, 2011. 21. Randsøe T and Hyldegaard O: Effect of oxygen breathing on micro oxygen bubbles in nitrogen- depleted rat adipose tissue at sea level and 25 kPa altitude exposures. J Appl Physiol; 113(3):426 - 433, 2012. 22. Keld T, Hansen EG, Holler NG, Rottensten H, Hyldegaard O and Jansen EC: Resuscitation by hyperbaric exposure from a venous gas emboli following laparoscopic surgery. Scand J Trauma Resusc Emerg Med: 20(1): 51, 2012. 23. Hyldegaard O: Treatment of Decompression Sickness During Breathing of Oxygen and Inert Gases. Doctoral Thesis, University of Copenhagen, public defence September 7.th, 2012. Pp 1-106, ISBN 978-87-995449-0-5. 24. Hansen MB, Treschow F, Skielboe M, Hyldegaard O, Jansen EC and Nielsen JB. Monitoring Cardiac Output during Hyperbaric Oxygen Therapy of Hemodynamically unstable Patients. J Diving Hyperb Med: Mar43(1):3-8, 2013. 25. Randsøe T and Hyldegaard O: Threshold altitude for bubble decay and stabilization i n rat adipose tissue at hypobaric exposures. Aviat Space Environ Med. July 84(7):675 -683, 2013. 26. Hansen MB, Jansen T, Hyldegaard O and Jansen EC: Chamber personel ’s use of Nitrox During Hyperbaric Oxygen Treatment - A Quality Study. J Undersea Hyperb Med; 40(5);395-402, 2013. 27. Hansen MB, Olsen NV and Hyldegaard O: Combined administration of hyperbaric oxygen and hydroxycobalamin improves cerebral metabolism after acute cyanide poisoning in rats. J Appl Physiol., 115(9):1254-61, 2013. 28. Randsøe T and Hyldegaard O: Treatment of micro air bubbles in rat adipose tissue at 25 kPa altitude exposures with Perflurocarbon Emulsions and Nitric Oxide. E J Appl Physiol, 114(1): 135 - 46, 2014. 29: Hansen MB, Kondziella D, Danielsen ER, Larsen VA, Jansen EC, Hyldegaard O. Cerebral proton magnetic resonance spectroscopy demonstrates reversibility of N-acetylaspartate/creatine in gray matter after delayed encephalopathy due to carbon monoxide intoxication: a case report. J Med Case Rep. 2014 Jun 19;8:211. 30. Randsoe T, Meehan CF, Broholm H, Hyldegaard O. Effect of nitric oxide on spinal evoked potentials and survival rate in rats with decompression sickness. J Appl Physiol (1985). 2015 Jan 1;118(1):20-8. 31. Hansen MB, Simonsen U, Garred P, Hyldegaard O. Biomarkers of necrotising soft tissue infections: aspects of the innate immune response and effects of hyperbaric oxygenation-the protocol of the prospective cohort BIONEC study. BMJ Open. 2015 May 11;5(5):e006995. doi: 10.1136/bmjopen-2014-006995.