2018

CBD Full Spectrum Hemp Extract Reference Guide

A Healthy Body and Mind Powered by Nature.

We are here to help others achieve a healthy body and mind, through the power of nature.

Hemp has been used world wide for thousands of years and offers many health benefits to its users. Our CBD products are:

Grown in Pesticide non-GMO Organic the USA Free

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. I. What is CBD? CBD is a natural compound extracted from the Hemp plant.

Important facts about CBD: Agricultural Act of 2014, within or outside of the State in which the industrial hemp is grown or cultivated. •Industrial hemp is a “cannabis plant” that can be grown in accordance with “Federal Hemp Farming Legislation “ the 2014 • CBD hemp oil is non-intoxicating unlike THC. Agriculture bill (The Farm Bill) and the proposed 2018 Hemp Farming Act. • 58% of CBD users are women

• Hemp is a much more vibrant plant than marijuana and is mostly • 41% of all CBD users use products daily grown outdoors, that costs significantly less than marijuana to grow • Over 90% of people who use CBD products will remain consumers •The hemp plant is much easier to process in order to extract it’s oil • Consumers are using CBD for depression, insomnia, anxiety, and joint pain • CBD hemp oil is legal, under the federal government through the “Farm Bill of 2014” • CBD hemp oil can be used to treat pets for numerous conditions • Hemp products can be shipped across state lines in accordance with the “Spending Bill of 216” allowing the • The conditions that can be treated by CBD hemp oil are “transportation, processing, sale, or use of industrial hemp significantly greater than the Medical Marijuana qualifying that is grown in accordance with subsection 7606 of the conditions in the state Ohio and other states

II. How it works

All cannabinoids, including CBD, attach themselves to certain receptors in the body to produce their effects. The human body produces certain cannabinoids of its own. The body has two receptors for cannabinoids called CB1 and CB2 receptors. CB1 receptors are found all around the body, but many are in the brain.

The CB1 receptors in the brain deal with coordination and movement, pain, emotions, and mood, thinking, appetite, and memories, among others. Cannabinoids attache to these receptors. CB2 receptors are more common in the immune system. They affect inflammation, pain, and can mostly be found in our spleen. It used to be thought that CBD acts on these CB2 receptors, but it appears now that CBD does not act on either receptor directly. Instead, it seems to influence the body to use more of its own cannabinoids. In other words, it causes our own immune systems to work to our benefit.

50% of people who have tried CBD, replaced their prescription drugs, with little to no side effects.

Benefits of using CBD Hemp products Because of the way that CBD acts in the body, it has many potential benefits. People commonly use many different types of prescription or over the counter medications to relieve pain and stiffness, including chronic pain.

Many people believe that CBD hemp oil offers a more natural way to reduce pain. A study published in the Journal of Experimental Medicine found that CBD significantly reduced chronic inflammation and pain in test studies. Many researchers suggest that the non-psychotropic compounds in CBD hemp products could be a new and alternative treatment for chronic inflammation and pain.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure any disease. Full Spectrum Hemp Extract

Full Spectrum Hemp Extract Vs. CBD Isolate

Full spectrum hemp extract and CBD isolate are two common forms of Hemp extract. CBD isolate is isolating the CBD from the rest of the hemp plant. It is refined to remove any additional cannabinoids, terpenes, and plant components found in the hemp plant. Isolates only contain one type of cannabinoid: CBD.

Full Spectrum Hemp Extract keeps the full properties of the hemp plant intact. In addition to CBD, this extract includes terpenes, other cannabinoids, vitamins, minerals, fatty acids, phytonutrients and other materials extracted from the whole hemp plant. The hemp plant naturally contains over 100 cannabinoids that provide their own unique properties and benefits. By keeping all of the plant components, full spectrum hemp extract benefits from the synergistic properties between the components. Scientists have found that plant components interact with one another to create an enhanced multiplier effect (compared to the component alone). Research has proven that Full spectrum hemp extract is more effective in treating health ailments than CBD alone.

Entourage effect

The term entourage effect was introduced in 1998 by Israeli scientists. The phrase refers to taking the entire spectrum of natural chemicals found in cannabis is more beneficial than only taking a single molecule compound.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure any disease. III. Health Conditions improved by CBD Hemp Oil*

Acne* Bipolar Disorder* Joint Pain or Inflammation* Osteoporosis*

ADD and ADHD* Cancer* Kidney Disease* Parkinson’s disease*

ALS* Digestive Issues* Liver Disease* Prion (Mad Cow Disease)*

AIDS* Depression* Metabolic Syndrome* PTSD*

Addictions* Diabetes* Migraine Headaches* Rheumatism*

Alzheimer’s disease* Endocrine Disorders* Mood Disorders* Schizophrenia*

Anorexia* Epilepsy and Seizures* Motion Sickness* Severe or Chronic Pain*

Antibiotic Resistance* Fibromyalgia* Multiple Sclerosis (MS)* Sickle Cell Anemia*

Anxiety* Glaucoma* Muscle Tension or Strain* Skin Conditions*

Atherosclerosis* Heart Disease* Nausea* Sleep Disorders*

Arthritis* Huntington’s disease* Neurodegeneration* Spinal Cord Injury*

Asthma* Inflammation* Obesity* Stress*

Autism* Irritable Bowel Syndrome* OCD* Stroke and TBI*

Relieves pain (analgesic) Treats psoriasis (anti-psoriatic)

Kills or slows bacteria growth Tranquilizing, used to manage (anorectic) psychosis (antipsychotic)

Reduces blood sugar levels (anti- Suppresses muscle spasms diabetic) (antispasmodic)

Reduces vomiting and nausea Relieves anxiety (anxiolytic) (anti-emetic) Promotes bone growth (bone stimulator) Reduces seizures and convulsion (anti-epileptic) Reduces function in the immune system (immunosuppressive) Reduces inflammation (anti- inflammatory) Reduces contractions in the small intestine (intestinal Reduces the risk of artery anti-prokinetic) blockage (anti-ischemic) Protects nervous system degeneration Inhibits cell growth in tumor cells & (neuroprotective) cancer cells (anti-proliferative)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. IV. Frequently Asked Questions

What are the side effects of using Full Spectrum Will CBD get me high? No, CBD is non-intoxicating. Hemp CBD Extract? Full Spectrum Hemp CBD Extract is very safe, but can interact with many common pharmaceuticals. Patients Will I have trouble with drug tests using CBD? Consult your doctor and/or employer if this is a concern. taking prescription medications should monitor changes in blood levels and, if need be, adjust dosage. Can I take clean remedies products with prescription Problematic interactions are more likely when medication? consuming high doses of CBD products. A preliminary CBD Full Spectrum Hemp Extract may improve report from the World Health Organization (WHO) metabolism of prescription drugs. We recommend states that “no public health problems…have been consulting your physician. associated with the use of pure CBD.” And that it hasn’t shown potential for dependence or abuse. We always recommend consulting with your physician if you have concerns.

What are cannabinoids? Cannabinoids are a group of fatty compounds found in hemp but also produced by other plants and the human body. They are the primary chemical compounds produced by the cannabis plant. These compounds are key players in normal immune and central nervous system functioning. There are more than 100 identified cannabinoids.

Hemp produces more than 100 different phytocannabinoids naturally. Of the 100+ non-intoxicating phytocannabinoids, Cannabidiol (CBD) is the most widely known. Others include Cannabigerol (CBG), Cannabichromene (CBC) and more.

Are your products lab tested? Yes, beyond all the state and federal requirements all our products are third party analytical lab tested and we can provide those results when needed. We test for impurities, pesticides, mold and mildew. This ensures our Full Spectrum Hemp CBD Extract is the cleanest of remedies.

Difference between Full Spectrum Hemp CBD Extract wellness tincture and a vape pen? Inhalation is good for treating acute symptoms that require immediate attention; the effects can be felt within 15 seconds and typically last for one to two hours. The effects of orally administered, under the tongue (Sublingual),Full Spectrum Hemp Oil can last for six hours or longer, but the onset of effects is much slower (5-30 minutes) than inhalation.

What is the optimal dosage of Full Spectrum Hemp CBD Extract: An effective dosage can range from as little as a few milligrams (drops) or more (1 dropper full). Begin with a small dose of high Full Spectrum Hemp Extract, especially if you have little to no experience with CBD products. Take a few small doses over the course of the day rather than one big dose. Use the same dose and ratio for several days. Observe the effects and if necessary adjust the frequency and dosage to desired effect. 900 mg For edible use, adults take 1/2 dropper (.50ml) under the tongue twice per day. 3,000 mg maximum strength for edible use, adults take 1-2 drops under the tongue. Increase dose and frequency as needed.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. V. Reasons people love using Full Spectrum Hemp Extract

• Non Addicting • Improves wellness

• Easy to use • Relaxing

• Derived from industrial hemp • Therapeutic and calming

• Legal in the US and countries worldwide • All natural and suitable for vegan, gluten free, and kosher diets • No reported side effects • Adjustable serving sizes • Easily combined with other products • Great value for the money • Soothes the senses

VI. Methods of consumption

Tinctures Tinctures are the most popular form of consumption for using CBD hemp oil. They can be taken in droplet form and placed under the tongue, or mixed with any liquid and then consumed. A huge variety of strengths are available, ranging from 10mg to 3,000 mg, per 30 ml (one ounce). However different bodies have different requirements and tolerances, and it may take a little experimentation to find the perfect dose for each individual.

Capsules, Caplets, Soft Gels Capsules are a fairly new method of medicating. Capsules come in different varieties containing different milligrams CBD for the pain or inflammation. Patients have stated that CBD capsules caplets, and soft gels are convenient for traveling long distances in a car or airplane to relieve the aches associated with travel.

Topicals, CBD hemp oil patches, lotions, sprays, and balms CBD oil can be used topically (on the skin) to relieve pain from certain conditions. The medication can be found in high demand in balm, lotion, or ointment. This is not a new use for CBD hemp oil products. In fact, prior to the time when most medication became available and people only had hemp plants to use for ailments, many patients would soak hemp leaves in alcohol and apply them as a poultice to an arthritic or swollen joint. Patients with arthritis, fibromyalgia, muscle and joint pains can testify to the easing of the aches and pains that they feel on a regular basis.Topical CBD preparations provide only local relief and do not have any effect on the brain.

Vaping Vaping CBD is one of the easiest methods available to consume. Vaping provides quick relief for consumers with chronic pain and health ailments. There are four basic components: battery, heating element (atomizer), mouthpiece and a chamber to hold the material to be vaped. The heating element vaporizes whatever material it comes in contact with the chamber and the user inhales the vapor through the mouthpiece. Effects take seconds and last only about an hour.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. VII. Drug to Drug interactions

CBD is one of the least toxic substances known. Therefore, it has very few drug interactions and a low potential to cause combined adverse effects, although the few that have been reported, should be made known.

CBD hemp products have no known lethal dose of LD50, which is the lethal dose that 50% of a sample would die from an overdose, measured in milligrams. The FDA estimates it to be over 40,000 mg. This means that an individual would have to consume over 1,500 pounds of CBD products in less than a 15 minute period in order for it to be fatal. This makes it one of the least toxic substances known. Therefore, it has very few drug interactions and a low potential to cause combined adverse effects, although the few that have been reported, should be made known.

Alcohol: Alcohol effects may be increased when combined with CBD, causing an increased risk of dizziness, loss of coordination, nausea and vomiting.

Opiates: Opiate based medications are highly toxic and have a high potential for overdose causing death. CBD combined with opiates can increase your risk of overdose.

Seizure disorders: CBD normally eliminates seizures, but might make seizure disorders worse in some people; in most other people, it will help control seizures.

Sedatives: Sedatives can make patients drowsy. Combining these medications with CBD products may cause extreme drowsiness and caution should be taken. Examples include but aren’t limited to: clonazepam, lorazepam, phenobarbital and Zolpidem.

SSRI’s: SSRI’s and other mood altering drugs have had reports of nervousness and irritability. Patients taking these medications should discuss CBD use with their prescribing physician. Examples: fluoxetine (Prozac) and Sertraline (Zoloft).

Pregnancy and breast-feeding: Those that are pregnant or breast-feeding should not consume CBD hemp products without consulting their physician.

Information excerpted from internet sources including the National Institutes of Health. This information is intended only to complement, not to replace or contradict any health or medical advice provided by healthcare professionals. Patients who have questions should contact their doctor.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. VIII. Cannabinoid Compounds

This section will address the scientific side of CBD. It is important to understand all that makes this incredible product effective.

CBD Cannabidiol CBD is a compound in cannabis that has medical effects, but does not make people feel “stoned” and can actually counter the intoxicating effects of THC. CBD is a compound that possesses a wide range of therapeutic benefits.

CBD is a very effective treatment option for severe social anxiety. CBD also turns “off” the cancer gene found in metastasis. CBD is a potent anti-psychotic medicine.

CBG – Cannabigerol CBN – Cannabinol Cannabigerol is a non-psychoactive cannabinoid CBN is a weak psychoactive cannabinoid found in the cannabis genus of plants. Cannabigerol found only in trace amounts in cannabis sativa is found in higher concentrations in hemp rather than and cannabis Indica. It is mostly a metabolite in varieties of cannabis for high THC content and their of THC. CBN acts as a weak *agonist of CB1 corresponding psychoactive properties. receptors but has a higher affinity to CB2 receptors, with lower affinities in comparison Cannabigerol has been shown to relieve inter-ocular to THC. Because of its somewhat selective pressure, which may be of benefit in the treatment of CB2 psychological agonism, it is used glaucoma. It can also be used to treat inflammatory experimentally as an immunosuppressant. bowel disease. CBN is psychoactive, although less so than CBGa – Cannabigerolic Acid THC. It helps reduce anxiety, unlike THC. It CBGa is the precursor to the three major branches of also helps with lapses in memory and cannabinoids: THCa, CBDa and CBGa. The plant disorientation. CBN also promotes has natural enzymes, called synthases that break uninterrupted sleep. CBGa down and mold it towards the desired branch. When any of the cannabinoid acids are exposed to *Agonist – a chemical compound that binds heat or prolonged light, they lose a molecule of to a receptor and activates the receptor to carbon dioxide CO2. produce a biological response.

While most strains of cannabis are less than 10% CBDa – Cannabidiolic Acid CBG, industrial hemp strains test as high as 94% CBDa is a major non-psychotropic CBG with as low as 0.001% THC. constituent of fiber-type cannabis plants and possesses diverse biological activities, What most people don’t understand, is that in its including anti-proliferative effects on cancer natural form, cannabis actually contains very little cells. CBDa inhibits migration of highly THC in its natural plant form. Upwards of 80% to invasive MDA-MB-231 human breast cancer 90% of the THC found in cannabis is actually in the cells by inhibiting growth of certain protein form of THCa until it goes through a process called cells. decarboxylation.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. VIII. Cannabinoid Compounds

CBC – Cannabichoromene CBCa – Cannabichromenic Acid CBC is a cannabinoid found in the cannabis plant. It CBCa is isolated from the cannabis hemp bears structural similarity to the other natural plant. The resin of this plant has shown a cannabinoids, including THC, CBD and CBG. variety of interesting pharmacologic Evidence has suggested that it plays a role in the activities, such as anti-inflammatory, anti- anti-inflammatory and anti-viral effects of cannabis fungal, and anti-microbial effects. It has and may contribute to the overall analgesic effect, also been used as a medicine and similar to that of medical marijuana. psychotomimetic drug since ancient times.

CBGa – Cannabigerolic Acid CBGa is a non-intoxicating crystalline cannabinoid found in the cannabis genus of plants. CBGa is the pre- cursor to CBG and is a kind of cannabinoid stem cell—meaning at least three branches of cannabinoids are derived from CBGa. Earlier harvests can increase the amount of CBG present at the expense of THC, CBD, and CBC. Industrial hemp plants are far higher in CBG, which is believed to be the result of a recessive gene that inhibits one of the synthases responsible for converting CBGa into other cannabinoids. Medical benefits include:

- Antibacterial – kills surface bacteria

- Antimicrobial – kills bacteria and fungus

- Anti-proliferative – inhibits cell growth

- Bone Stimulant – promotes bone growth

- Anti-oxidant – prevents or delays some types of cell damage

- Anti-inflammatory – reduces inflammation

Combining Strains: Alone, none of the major cannabinoids are as effective as when they work together. The above cannabinoids also work with minor compounds, and this is probably one reason that medical, non-natural replacements like marinol do not work very well.

Professional CBD hemp growers can analyze their strains and grow medication for patients with the desired range of levels of each major cannabinoid. Using their knowledge, CBD Consultants, find the right combination to treat specific conditions and find maximum relief.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure any diseases. IX. What are terpenes?

Terpenoids, otherwise known as terpenes, are a category of phytochemicals produced by many plants including hemp that may possess a wide range of therapeutic benefits.

Overview Terpenoids, otherwise known as terpenes, are a category of phytochemicals produced by many plants including hemp that may possess a wide range of therapeutic benefits. Hemp contains over 200 terpenes, some of which are in the therapeutically significant range of over 0.05%, though the terpenes reaching this concentration vary by strain. One of these terpenes is the aptly named terpinolene.

Terpinolene is also found in apple, cumin, lilac and tea tree, and has a smoky or woody scent. All terpenes have the same molecular formula, weight and framework, but they differ in the placement of the carbon-carbon double bonds. It is the terpenes, not the cannabinoids that are responsible for the aroma of hemp plants. Terpinolene is unusual among the terpenes and cannabinoids, as it is neither anti-inflammatory nor analgesic. It does help fight cancer like most other cannabinoids, and it is anti-fungal, as well as anti-bacterial. Terpinolene is also a sedative which may also may be helpful in cancer treatment, if patients are having difficulty sleeping, as it works in conjunction with other terpenes and cannabinoids like linalool and cannabinol. So how can this terpene aid the effects of hemp’s “main constituents? Despite the absence of the typical effects, it may have sedative and antioxidant properties, just as cannabinoids such as cannabidiol (CBD) have shown, as well as antimicrobial activity.

In a study on mice, this terpene was isolated as a primary active ingredient in Microtoena patchouliioil, which was found to have sedative activity. Another experiment on smell-impaired mice showed a sedative effect that was apparent after absorption through the nose. This may help to explain the improvements in insomnia that are sometimes reported from using hemp products. Other terpenes, such as linalool, may add to these effects.

The antioxidant properties of terpinolene could also aid the anti-inflammatory substances in hemp by protecting the body’s tissues against damage, as oxidative free radicals may provide the initial assault that leads to inflammation, or act as a sustaining factor. A study trying to find damaging effects of terpinolene actually ended up finding that it increased the antioxidant capacity of cells, and was not toxic to the DNA of human immune cells.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure any diseases. Cardiovascular disease and oxidative damage One condition that may be driven by oxidative damage is cardiovascular disease, as damaged LDL cholesterol has been shown to be behind artery plaque formation. Another study on a high-terpinolene essential oil found that this terpene protected LDL cholesterol from oxidation by shielding its fat and protein components. Its protective effects came from slowing the oxidation of carotenoids present in LDL; carotenoids are versions of vitamin A which show antioxidant ability.

Like many terpenes, terpinolene has demonstrated antimicrobial effects

While research on these actions have not yet focused on this terpene alone, one study has tested the effects of Diplotaenia damavandica, a plant native to Iran containing relatively high levels of terpinolene. Oil from the plant’s leaves, roots and seeds were tested, with the leaf oil containing the highest levels of terpinolene at 20%. All three oils were found to have antibacterial effects against E. coli, golden staph and several others. The leaf oil was the most potent, including against the fungal species.

When the main compounds of these oils were tested individually, terpinolene was the most potent against all microbes in both the disc test and when measuring mean inhibitory concentration (MIC). This included activity against Candida albicans, a common fungal infection. Overall, terpinolene may be another phytochemical behind the reported superiority of whole hemp extracts over CBD alone, though research on human participants and on hemp strains with high levels of this terpene are needed.

Currently Being Studied For Antimicrobial: Terpinolene may possess antimicrobial properties but there has yet to be a study which looked at solely its antibacterial abilities; everything has looked at whole-plant oil extracts. In 1995, researchers examined tea tree oil for its antimicrobial properties and found it to have significant potential as an antimicrobial agent. Tea tree oil is made up of numerous terpenes including terpinolene but also cineole, linalool, and over a dozen others.

A decade later in 2005, a team of researchers looked at the essential oil from Diplotaenia damavandica, a plant native to Iran whose oil is made up of 20% terpinolene. They found it to be effective against E coli and various other pathogens including Staphylococcus aureus (the non-drug resistant cousin of MRSA) and Staphylococcus epidermidis, a related bacteria commonly acquired in hospitals.

An article published by Natural Product Research in 2010, looking at the oil from a different Iranian plant, which had only a 6.12% terpinolene content, found the oil to be an effective antibacterial agent. An article published in 2011 by Natural Product Communications looking at the oil from bicolor Gypsophila, a plant in the clove family, found its oil to have a moderately strong effect against bacteria and a potent one against fungi.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure any diseases. X. The most common cannabis terpenes

Alpha-Pinene, Beta-Pinene Myrcene

Aroma: Pine Aroma: Musky, cloves, earthy, herbal with notes of citrus and tropical fruit

Effects: Alertness, memory retention, counteracts some Effects: Sedating “couchlock” effect, relaxing THC effects

Medical Value: Antioxidant, anti-carcinogenic; good Medical Value: Asthma, antiseptic for muscle Linalool tension, sleeplessness, pain, inflammation, depression

Also Found In: Mango, lemongrass, thyme, hops

Caryophyllene

Aroma: Floral, citrus, candy

Effects: Anxiety relief and sedation

Medical Value: Anti-anxiety, anti-convulsant, anti- Aroma: Pepper, spicy, woody, cloves depressant, anti-acne Effects: No detectable physical effects Also Found In: Lavender Medical Value: Gastro protective, anti-inflammatory; Limonene good for arthritis, ulcers, autoimmune disorders, and other gastrointestinal complications

Also Found In: Black pepper, cloves, cotton

Aroma: Citrus

Effects: Elevated mood, stress relief

Medical Value: Antifungal, anti-bacterial, anti-carcinogenic, dissolves gallstones, mood-enhancer; may treat gastrointestinal complications, heartburn, depression

Also Found In: Fruit rinds, rosemary, juniper, peppermint

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure any diseases. XI. The Endocannabinoid System

The ECS is a system within the human body that produces natural chemicals (cannabinoids) that interact with the ECS receptors in the brain and other areas of the body, specifically, the spleen, to regulate important body functions.

Medical/Scientific overview justifying the use of CBD hemp products Cannabis has been significantly used by humans for medicinal purposes for probably thousands of years. The components in cannabis plants are known as cannabinoids, first isolated as distinct compounds in the 1940’s

The Endocannabinoid System (ECS) was discovered in the 1990’s by Doctor Ralph Mechoulam, an Israeli research scientist. The ECS is a system within the human body that produces natural chemicals (cannabinoids) that interact with the ECS receptors in the brain and other areas of the body, specifically, the spleen, to regulate important body functions. The ECS controls how a person feels, moves, thinks, and reacts.

The specific functions within the body that the ECS effects are:

•Appetite

•Sleep

•Mood

•Memory

•Sensation

•Pain

•Immune system

Cannabinoids are a class of chemical compounds that include Phytocannabinoids, which are the natural compounds found in the cannabis plant. The chemical compounds, which mimic the Phytocannabinoids that are known as endo-cannabinoids that are natural compounds found in the nervous system of vertebrate life forms.

Just as there are opioid receptors in the brain that recognize morphine and its byproducts that modulate pain reception, there are cannabinoid receptors that have been recognized in the human body. Before 1988, it was speculated that cannabinoids produced their physiological and psychological effects via non-specific interactions with cellular membranes of tissue located in the nervous system.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or cure any disease. Full Spectrum hemp extract is more effective in treating health ailments than CBD alone.

With the discovery of cannabinoid receptors in the late 1980’s and early 1990’s, it became clear that there were specific binding sites for both Phytocannabinoids and endo-cannabinoid products in nervous system tissues. These receptors have been found in all vertebrate life forms including reptiles, fish, birds, amphibians and mammals. There are now two recognized cannabinoid receptors in human beings and they are as follows:

Cannabinoid Receptor #1 (CB1) is found in the brain specifically in the basal ganglia, limbic system and also in the hippocampus. These receptors have also been found in other areas of the brain in lesser concentrations including the cerebellum and the medulla oblongata. It appears that when endo- cannabinoids or Phytocannabinoids that are found in CBD Hemp plants, bind to these receptor sites in the brain, analgesic and anti-emetic effects are mediated.

Cannabinoid Receptor #2 (CB2) are found in the peripheral nervous system and in the microglia of the human cerebellum and also in the immune system, especially the spleen. It appears that CB2 receptors are responsible for anti-inflammatory remediation. These second receptors were discovered in 1993 and they are not thought to be generally distributed in the human body unless there is some form of injury or neuro-inflammatory condition that is chronic in nature. The binding of cannabinoids to the CB2 receptor site likely results in the clinical benefit of decreasing pain reception in chronic inflammatory conditions.

The scientific literature suggests that a medical benefit from utilization of CBD Full Spectrum Hemp Extract is because of the inherent ability of the Phytocannabinoids found in the plant material to bind to the multiple receptors that are already present in the human body as outlined. The Phytocannabinoids that bind to the cannabinoid receptors in the human body are concentrated in a vicious resin that is produced in the glandular structures in the bud of the plant, which are known as trichromes. In addition to cannabinoids, this resin is rich in terpenes and is responsible for the foul odor that is generally associated with the cannabis plant. Phytocannabinoids are nearly insoluble in water but are found to be soluble in lipids, alcohol, and other non-polar organic solvents.

At least 85 Phytocannabinoids have been isolated from the cannabis plant. Tetrahydrocannabinol (THC), cannabidiol (CBD), being the two most common.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat, cure any disease.

26600 Detroit Road, Suite 300 Westlake, OH 44145 P: (216) 566-8200 F: (216) 566-0213 www.sseg-law.com

Legal Opinion Letter

SUMMARY: CBD obtained from the mature stalks of the cannabis plant is legal to buy and sell throughout the United States. Further, CBD obtained from the flowers of industrial hemp plants—grown in states that are compliant with the 2014 U.S. Farm Bill—may be processed, sold and transported throughout those states and other states (unless a state has laws barring CBD). Ohio does not have any laws barring CBD.

2014 FARM BILL: The Farm Bill defines and permits the growth, cultivation and research of industrial hemp, under defined parameters. See Agricultural Act of 2014, Pub. L. 113-79, title. VIII, Section 7606. The Farm Bill distinguishes “industrial hemp” and “marijuana” based on the concentration of the psychoactive compound THC contained in each product. As such, Congress recognized that industrial hemp products derived from any part of the plant (including the flower) can be used for industrial purposes and would not fall under the Controlled Substances Act as long as the plant was cultivated to be below 0.3% THC concentration. Accordingly, CBD extracted from flowers and leaves of the industrial hemp plant is legal if produced, sold and processed in a state, which has enacted hemp laws pursuant to the 2014 Farm Bill.

Since the passage of the 2014 Farm Bill, Ohio has not implemented legislation allowing industrial hemp research or pilot programs

2016 SPENDING BILL: Congress passed the Spending Bill provisions, expressly prohibiting the government from spending funds in contravention of the Farm Bill and thus, prohibiting the DEA from interfering with the interstate transportation of industrial hemp grown pursuant to the Farm Bill. See Consolidated Appropriations Act, 2016 Pub. L. No. 114-113, Section 763, 129 Stat. 1175, 2285 (2016).

As such, pursuant to the 2016 Spending Bill, industrial hemp may be processed, transported to and sold in states that have not enacted industrial hemp laws pursuant to the 2014 Farm Bill. See also USA v. Marin Alliance for Medical Marijuana

CONTROLLED SUBSTANCES ACT: As you cannot find CBD listed in the Controlled Substances Act, it does not appear that Congress scheduled CBD. This is contrary to the DEA’s position.

FEDERAL DRUG ADMINISTRATION: The FDA considers CBD an “unapproved new drug.” In February 2016, the FDA issued a warning letter to companies that manufacturer and market hemp oils claiming to be “rich in CBD” and promising cures for conditions such as cancers, autism and epilepsy—none of which have been tested by the FDA. The FDA has not moved in court to shut down any CBD companies or seize products. The workaround for companies selling CBD is simply to make no medical claims and link to outside independent research thus, allowing buyers to draw their own conclusions.

OHIO LAW: Pursuant to the Farm and Spending Bills, CBD Oil derived from Industrial Hemp is legal in all fifty states, as this plant never has more than trace amounts of THC. The possession and use of CBD oil derived from Hemp is legal, but possession and use of CBD oil derived from marijuana would be governed by Ohio’s medical marijuana laws. Accordingly, it is illegal to possess CBD derived from marijuana unless permitted under Ohio’s medical marijuana laws. The following forms of medical marijuana are permitted under Ohio’s Medical Marijuaba laws: oils, tinctures, plant materials, edibles and patches.

Jazmyn J. Stover | Partner 26600 Detroit Rd. | Cleveland, OH | 44145 P: (216) 566-8200 F: (216) 566-0213 E-mail: WWW.SSEG-LAW.COM