What Happened After Proposition 215 Passed?
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
HPLC Application Note Cannabinoids
HPLC Application Note Cannabinoids Preparative Purification of Results and Discussion Cannabidiol from Hemp Oil Extract Triart C18 was chosen for its overall durability Jeffrey A. Kakaley, YMC America Inc. and scalability to larger preparative size particles. Water and ethanol were chosen as the mobile phase This application note details a loading study for solvents due to the well-understood human toxicity of purifying cannabidiol (CBD) from a commercially ethanol, making it a better choice as compared to available “high-CBD” hemp oil extract. traditional LC solvents such as methanol or acetonitrile. A number of different isocratic conditions were Background evaluated before settling on the 25:75 water:ethanol As new research is performed to evaluate the configuration which gave the best compromise medicinal properties of cannabis, the need to purify between resolution and overall runtime. The initial individual cannabinoids has increased dramatically. method was worked out on a 250x4.6mm, 5µm Triart Products currently on the market are typically impure C18 column and then scaled to a 250x4.6mm, 10µm extracts that contain a mixture of many different Triart C18 column to perform the loading study. cannabinoid compounds. This application note Loadings of 10, 40, 80, and 100µL of neat hemp oil investigates the use of HPLC and YMC’s Triart C18 were run to determine the highest sample load that stationary phase to purify CBD from a hemp oil could be placed on the column. Examples can be seen extract. in Figures 1 and 2 below, with the CBD fraction highlighted in orange: Sample Preparation Figure 1: 10µL Hemp Oil on 5µm Triart C18 Injections of the hemp oil extract were made using the neat oil with no dilution. -
The Determination of CBD and General Cannabinoid Content In
No. SSI-HPLC-018 High Performance Liquid Chromatography The Determination of CBD and General Cannabinoid Content in Hemp Oils Using HPLC with UV Detection No. HPLC-018 ■ Introduction Medical marijuana generally possesses high levels of CBD oil is derived as concentrate from CO2 or the therapeutic cannabidiol, CBD, and lower levels butane extraction of hemp, sometimes followed by (generally less than 0.3%) of the psychotropic steam distillation or ethanol distillation for tetrahydrocannabinol, d9-THC. Pain mitigation and purification. The Farm Bill of 2014 distinguishes reduced severity of nausea and seizures are just a hemp from marijuana, yet interpreting the law is few of the therapeutic benefits reported by medical difficult in that “CBD oil” may be classified as cannabis patients. Little has been done to better marijuana. understand the chemistry of benefits from CBD. To complicate matters, there is evidence that a The FDA has issued warning letters to firms that combination of CBD, a host of other minor market unapproved new drugs allegedly contain cannabinoids and a complex array of terpenoids may CBD. As part of these actions, the FDA has be the most beneficial – called the “entourage determined the cannabinoid content of some hemp effect.” CBD-rich oil has become increasingly products and many were found to contain levels of popular and is administered via sublingual drops, gel CBD that are very different from the label claim. It is capsules or as a topical ointment. important to note that such products are not approved by the FDA for the diagnosis, cure, The main source of CBD-rich oil is industrial hemp. -
Article III Judges and the Initiative Process: Are Article III Judges Hopelessly Elitist
Loyola of Los Angeles Law Review Volume 31 Number 4 Fritz B. Burns Lecture: Euthanasia, Morality & Law and Symposium on the Article 8 California Initiative Process 6-1-1998 Article III Judges and the Initiative Process: Are Article III Judges Hopelessly Elitist Michael Vitiello Andrew J. Glendon Follow this and additional works at: https://digitalcommons.lmu.edu/llr Part of the Law Commons Recommended Citation Michael Vitiello & Andrew J. Glendon, Article III Judges and the Initiative Process: Are Article III Judges Hopelessly Elitist, 31 Loy. L.A. L. Rev. 1275 (1998). Available at: https://digitalcommons.lmu.edu/llr/vol31/iss4/8 This Symposium is brought to you for free and open access by the Law Reviews at Digital Commons @ Loyola Marymount University and Loyola Law School. It has been accepted for inclusion in Loyola of Los Angeles Law Review by an authorized administrator of Digital Commons@Loyola Marymount University and Loyola Law School. For more information, please contact [email protected]. ARTICLE I JUDGES AND THE INITIATIVE PROCESS: ARE ARTICLE II JUDGES HOPELESSLY ELITIST? Michael Vitiello* and Andrew J. Glendon** I. INTRODUcTION The initiative process, a product of the Progressive and Populist reform efforts,1 is so attractive in theory that it seems almost unholy to challenge its continuing vitality. Conceived as a way to circumvent a legislature under the control of monied interests and the railroads, the initiative process demonstrated the Progressive ideology that the people needed a vehicle to "directly battle against the corporations' organized interests and influential lobbyists."' While the theoretical underpinnings of the initiative process may be attractive, the reality of the initiative process, in its evolvement, is singularly unattractive. -
The Ultimate Guide to CBD Oil
The Ultimate Guide to CBD Oil What is CBD? CBD (cannabidiol) is a cannabinoid – a biologically active cannabis compound that has been proven to have significant health benefits. The cannabis plant is composed of a complex chemical mixture that includes phyto-cannabinoids, terpenoids, flavanoids, steroids and enzymes. Cannabinoids help by modulating many physiological systems in the human brain and body. There are many active cannabinoids that have been identified in cannabis and of these tetrahydrocannabinol (THC) and cannabidiol (CBD) are usually present in the highest concentrations and have been studied the most extensively. THC is the psycho-active component, which is used recreationally to give the “high”. CBD is non-psychoactive, meaning it does not make people feel “high or stoned” so that means daily tasks, like driving, taking care of children and working, will not be affected or put at risk by using CBD. There are no dulled senses to inhibit consumers. While this makes CBD is a poor choice for recreational users, it gives a significant advantage as a tonic, since it has minimal side effects. This makes CBD an appealing option for people looking for relief from various conditions such as inflammation, pain, anxiety, psychosis, seizures, spasms, etc -- without feelings of lethargy. CBD rich hemp oil, the essential oil of the hemp plant, has over 480 natural compounds including 100 or so cannabinoids (CBD and THC are two) and over 120 terpenes (part of a plants essential oils which contribute to a plant’s scent, flavour and colour) along with amino acids, proteins, enzymes, ketones, fatty acids, steroids, flavonoids, vitamins and more. -
Harvey Milk Archives--Scott Smith Collection, 1930-1995GLC 35
http://oac.cdlib.org/findaid/ark:/13030/c8x63q17 No online items Harvey Milk Archives--Scott Smith Collection, 1930-1995GLC 35 Finding aid prepared by Tim Wilson James C. Hormel LGBTQIA Center, San Francisco Public Library 100 Larkin Street San Francisco, CA, 94102 (415) 557-4400 [email protected] 2003 Harvey Milk Archives--Scott Smith GLC 35 1 Collection, 1930-1995GLC 35 Title: Harvey Milk Archives--Scott Smith Collection, Date (inclusive): 1930-1995 Date (bulk): 1973-1985 Collection Identifier: GLC 35 Creator: Milk, Harvey Physical Description: 28 cubic feet Contributing Institution: James C. Hormel LGBTQIA Center, San Francisco Public Library 100 Larkin Street San Francisco, CA, 94102 (415) 557-4400 [email protected] Abstract: Harvey Milk was the first gay man elected to the San Francisco Board of Supervisors. Scott Smith was his partner and friend. The collection documents the personal and political life of Harvey Milk, and the personal life of Scott Smith. Milk's political papers include issue files from the Board of Supervisors, as well as speeches and campaign literature. The photographs document Milk's and Smith's activities in the gay community. Physical Location: The collection is stored onsite. Language of Materials: Collection materials are in English. Access The collection is available for use during San Francisco History Center hours, with photographs available during Photo Desk hours. Publication Rights All requests for permission to publish or quote from manuscripts must be submitted in writing to the City Archivist. Permission for publication is given on behalf of the San Francisco Public Library as the copyright holder. Preferred Citation [Identification of item], Harvey Milk Archives--Scott Smith Collection (GLC 35), LGBTQIA Center, San Francisco Public Library. -
CBD) Information About CBD in Cannabis and Hemp Products Under the New Cannabis Act
ALL ABOUT CANNABIDIOL (CBD) Information about CBD in cannabis and hemp products under the new Cannabis Act WHAT IS CBD? The cannabis plant contains hundreds of different chemical constituents, such as cannabinoids, terpenes and flavonoids. Currently, over 100 chemical substances collectively known as cannabinoids have been identified. Cannabinoids that are derived from cannabis plants are sometimes referred to as phytocannabinoids. Cannabidiol (CBD) is one of these cannabinoids. Unlike tetrahydrocannabinol (THC) - the most well-known cannabinoid in cannabis, responsible for the high or intoxication of consuming cannabis - CBD does not produce a high or intoxicating effect. However, there is some evidence that CBD may influence some of the effects that THC has on the brain. CBD is also being studied for its possible therapeutic uses; it has received market approval in the United States for two severe forms of epilepsy. CBD can be found in varieties of the cannabis plant, including hemp plants. All phytocannabinoids, whether derived from a cannabis plant or produced by synthesis, including both THC and CBD, are regulated under the new Cannabis Act and its regulations, which came into force on October 17, 2018. HOW IS CBD REGULATED IN CANADA? Under the Cannabis Act, many activities with phytocannabinoids, CBD included, remain prohibited, except for the specific cases authorized by the Act and its regulations, which include strict controls on possession, production, sale, and distribution. While Health Canada oversees the production of cannabis products, the provinces and territories oversee the distribution and retail aspects of the cannabis supply chain. Health Canada remains responsible for overseeing the distribution and sale of cannabis and any CBD-containing cannabis products for medical purposes. -
Hemp Cbd Scorecard an Evaluation of Hemp Cbd Producers
HEMP CBD SCORECARD AN EVALUATION OF HEMP CBD PRODUCERS SEPTEMBER 2019 www.centerforfoodsafety.org CENTER FOR FOOD SAFETY (CFS) is a national non-profit public interest and environmental advocacy organization working to empower people, support farmers, and protect the earth from the harmful impacts of industrial agriculture. We inform and engage our nearly one million members and the general public about food and personal care products so that they can make fully-informed decisions in the marketplace. Project Manager and Editor: REBECCA SPECTOR Writers: KELSEY KRUGER, ANNA SCIARUTO Researchers: KELSEY KRUGER, JULIA RANNEY, ANNA SCIARUTO Design: DANIELA SKLAN | HUMMINGBIRD DESIGN STUDIO Published in partnership with the Center for Cannabis Safety. CENTER FOR CA NNABIS SAFE TY www.centerforcannabissafety.org CFS evaluated 40 companies that sell hemp CBD products to compare product policies and practices. Nearly half of the companies received a failing or near failing EXECUTIVE SUMMARY grade (“D” or “F”). ENTER FOR FOOD SAFETY ’S (CFS) “Hemp CBD Scorecard” evaluates many of Cthe top hemp CBD producers on their production and processing methods, testing Only 4 companies protocols, and transparency to consumers. received an “A.” There has been a rapidly growing interest in oils, tinctures, capsules, body lotions, and other personal care products containing cannabidiol, better known as CBD, derived from hemp. These products are popular because of their multiple uses, including potential healing properties and their ability to calm both humans and pets. CBD is one of the naturally occurring, non-psychoactive cannabinoids found in cannabis plants, specifically within the hemp plant. 1 This product has become infamous for its purported ability to help reduce pain and anxiety, leading to a huge growth in the market for products containing CBD. -
Medical Marijuana: Getting in the Weeds
Medical Marijuana: Getting In the Weeds Dianne Tharp, PharmD, BPharm, BCPS, CPE Clinical Pharmacist May 17, 2016 1 Disclaimer The views and opinions expressed in this webinar, and/or any related material, are solely those of the original authors and contributors and do not represent the views and opinions of Healthcare Solutions, Inc. and its affiliates. 2 AGENDA Marijuana vs What is MEDICAL Is Marijuana Why Marijuana, Why Marijuana (MMJ)? Medicine? Industrial Hemp Now? Smoking and Misuse Conclusion Diseases and Medical Effects and Side of Marijuana Marijuana: What the Effects of Marijuana Studies Show 3 1 What is MMJ? Dried flowers and leaves of the Cannabis (marijuana) plant taken for a desired medical purpose 4 SYNTHETIC “MARIJUANA” FLOODS TAMPA BAY AREA Associated Press March 28, 2016 5 SYNTHETIC “MARIJUANA” IS NOT MEDICAL MARIJUANA “ …What makes spice dangerous is how easy it is to get, its inexpensive price and the difficulty of following through with prosecution. While it is called synthetic marijuana, officials say it has nothing to do with the leafy drug that is being legalized for medical use and decriminalized in some U.S. states and cities. Synthetic marijuana is made by taking dried plant material and soaking it in ever‐changing chemical combinations. Packets of the drug used to be available in convenience stores alongside packs of chewing gum and candy bars, and sometimes still are, O'Connor said. Those packets often are rolled into individual spice cigarettes, which sell on the street for $1 or $2 each. They don't know -
Industrial Hemp (Cannabis Sativa Subsp
molecules Review Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals H. P. Vasantha Rupasinghe 1,* , Amy Davis 1, Shanthanu K. Kumar 2, Beth Murray 1 and Valtcho D. Zheljazkov 3 1 Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada; [email protected] (A.D.); [email protected] (B.M.) 2 Section of Horticulture, School of Integrative Plant Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14850, USA; [email protected] 3 Department of Crop and Soil Science, 431A Crop Science Building, 3050 SW Campus Way, Oregon State University, Corvallis, OR 97331, USA; [email protected] * Correspondence: [email protected] Academic Editor: Severina Pacifico Received: 5 August 2020; Accepted: 2 September 2020; Published: 7 September 2020 Abstract: Industrial hemp (Cannabis sativa L., Cannabaceae) is an ancient cultivated plant originating from Central Asia and historically has been a multi-use crop valued for its fiber, food, and medicinal uses. Various oriental and Asian cultures kept records of its production and numerous uses. Due to the similarities between industrial hemp (fiber and grain) and the narcotic/medical type of Cannabis, the production of industrial hemp was prohibited in most countries, wiping out centuries of learning and genetic resources. In the past two decades, most countries have legalized industrial hemp production, prompting a significant amount of research on the health benefits of hemp and hemp products. Current research is yet to verify the various health claims of the numerous commercially available hemp products. -
Missouri Health & Wellness Featured in October Issue of Greenway
GREENWAY SEPTEMBER/OCTOBER 2020 GREENWAYTHE MISSOURI CANNABIS INDUSTRY MAGAZINE INSIDE MISSOURI’S FIRST FACILITIES P. 39 THE INFUSER MACHINE SHOWDOWN P. 20 1 on the cover MEET MORE MISSOURI BRANDSMOGREENWAY.COM P. 27 MH&W Dispensary’s green cross, located inside CUTTING CULTIVATION COSTS P. 90 GREENWAY CHAIRMAN OF THE BOARD GREENWAY John Curtis | Beleaf (St. Louis) TRANSPORTATION, TECHNOLOGY HEALTHCARE, EDUCATION AND AND SECURITY COMMITTEE TRAINING COMMITTEE CULTIVATION Chair: Larry Ellison Co-Chair: Dr. Mimi Vo, MD CULTIVATION COMMITTEE Ozarx | CST Solutions (Springfield) (St. Louis) Bradford Goette Co-Chair: Cindy Northcutt, RN, BSN, JD Chair: John Mueller Nirvana | Bold Lane Transport (St. Louis) Kintsugi | Soulful Cannabis (SPR) Greenlight (Kansas City) GOVERNMENT MANUFACTURING Michael Allen Chip Sheppard AFFAIRS AND TESTING Chris McHugh 5th Meridian (Cape Girardeau) CECB Law (Springfield) JosephJoseph HollanderHollander Craft CraftCraft LLC PCLLC (Kansas(Kansas (Kansas City) City) City) Dacia Betts Hannah Bush David Alport MOCANNTrade G5 Express (St. Louis) Nirvana Investments (St. Louis) BOARD OF DIRECTORS Bridge City Collective | SLCC (KC/STL) Joe Delia Natalie Brown Mike Birkel Green Farms (St. Louis/Cuba) MoCann Testing - EKG Labs (Perryville) Birkel Electric (St. Louis) Kevin Ellison Zach Greene Brian Fox CST Solutions (Springfield) Quarter Coast Consulting (St. Louis) Greene Fox (St. Louis) HEALTHCARE, TRANSPORTATION, Allen Fortner Dr. Patricia Hurford, MD, MS EDUCATION AND TECHNOLOGY AND Susan Griffith TRAINING SECURITY Executive Security Specialists (Springfield) SOAR Medical (St Louis) CAMP (St. Louis) Tiffany Maggard Dr. Eboni January Mark Hendren Heffernan Insurance (Springfield) Greenlight Dispensary (STL/KC) Flora Farms (Joplin/Humansville) Joe Patterson Dena Ladd Ashley Picillo DISPENSARY Ceres Mgmt Group (St. Louis) Missouri Cures (St. -
Important Dates in Hemp History 10,000-Year History of Marijuana Use in the World
Important dates in Hemp History 10,000-year History of Marijuana use in the World 8,000+ BCE Use of hemp cord in pottery identified at ancient village site dating back over 10,000 years, located in the area of modern day Taiwan. 6,000 BCE Cannabis seeds and oil used for food in China. 4,000 BCE Textiles made of hemp are usedina. in China and Turkestan. 2,737 BCE First recorded use of cannabis as medicine by Emperor Shen Neng of China. 1,500 BCE Cannabis cultivated in China for food and fiber. Scythians cultivate cannabis and use it to weave fine hemp cloth. 100 BCE First evidence of hemp paper, invented in China. 100 Imported hemp rope appears in England. 105 Legend suggests that Ts'ai Lun invents hemp paper in China, 200 years after its actual appearance (see 100 BCE above). 300 A young woman in Jerusalem receives medical marijuana during childbirth. 570 The French queen Arnegunde is buried with hemp cloth. 500-600 The Jewish Talmud mentions the euphoriant properties of Cannabis. 850 Vikings take hemp rope and seeds to Iceland. 900 Arabs learn techniques for making hemp paper. 1271-1295 Marco Polo brings cannabis to Europe. 1300 Ethiopian pipes containing marijuana suggest the herb has spread from Egypt to the rest of Africa. 1533 King Henry VIII fines farmers if they do not raise hemp for industrial use. 1549 Angolan slaves brought cannabis with them to the sugar plantations of northeastern Brazil. They were permitted to plant their cannabis between rows of cane, and to smoke it between harvests. -
2019 Update on Cannabidiol and Hemp Products
2019 Update on Cannabidiol and Hemp Products Presented by: Charles LoDico, M.S., F-ABFT Senior Chemist/Toxicologist Division of Workplace Programs Drug Testing Advisory Board June 11 , 2019 1 Presentation Objectives • Overview Marijuana • Potency • Scheduling and Research, • Policy • Commercialization of Marijuana 2 Marijuana Contains Over 400 Chemical Compounds: • 110 + Cannabinoids • Δ 9-THC (psychoactive) • CBD (non-psychoactive) • 200 + Terpenes (odor) • Flavonoids (color) 3 Trichome of Marijuana 4 Cultivated Throughout Recorded History Different Uses: • Industrial Fiber (rope, clothes) • Seed Oil (hemp oil) • Food (ground hemp seed for flour) • Recreation ( “high”) • Religious Customs (native cultures in rituals) • Medicine (Marinol®,and Epidiolex® (CBD)) 5 Cannabis Sativa L Cannabis – Hemp - Marijuana Commercial Hemp “Medical”/ Recreational Hemp CBD CBD CBD CBD CBD CBD CBD CBD CBD CBD CBD 6 Structural Similarity of CBD and Δ9-THC Chemistry Δ 9-THC CBD Molar Mass 314.469 Molar Mass 314.464 C-21 H-30 O-2 C-21 H-30 O-2 7 Potency: The New Normal • 1980s Marijuana: 4% THC • Mexican Marijuana: 6 - 11% THC • Current 2019 THC: 13 - 20% THC • Hashish/Hashish Oil: 20 - 40% THC • New Concentrates: 40 - 80% THC 8 Average THC and CBD % Marijuana Seizures 1995 – 2014 9 University of Mississippi, Potency MonitoringProgram Marijuana’s Acute Effects Cognition – Impaired short-term memory – Difficulty with complex tasks – Difficulty Learning Executive Function – Impaired decision-making – Increased risky behavior Mood (especially after high doses or edibles) – Anxiety – panic attacks – Psychosis - paranoia 10 List of Known Marijuana Risk’s • Psychosis • Agitated Delirum • Suicides • Seizures • Drugged Driving • Cannabinoid Hyperemesis Syndrome • Cardiovascular Effects • Pulmonary Affects • Contaminant Infections • Allergic Reactions • Anti-Coagulant effects due to contaminants 11 Consuming Marijuana • Smoking – Marijuana is absorbed through the capillaries in the lungs.