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Hyperthyroidism with an FSH- and TSH-Secreting Pituitary Adenoma
• Hyperthyroidism with an FSH- and TSH-secreting pituitary adenoma JOHN BERMINGHAM, DO LOUIS C. HAENEL, DO A 34-year-old man was found noma is rare. The combined secretion of follicle- to have elevated thyroxine (T 4 ), triiodothy- stimulating hormone (FSH) and TSH by a pi- ronine (T3 ), calculated free T4 , thyroid- tuitary adenoma is rarer. But with current stimulating hormone (TSH), follicle-stimu- widespread use of TSH assays, plus the future lating hormone (FSH), and alpha subunits clinical availability of more sensitive TSH as- of TSH and FSH. A computed tomography says as well as TSH bioactivity testing, more scan of the head showed a 16-mm mac- patients will have pituitary-induced hyperthy- roadenoma of the pituitary gland. There roidism correctly diagnosed, and the disorder was no evidence of loss or excess secre- will be better understood. tion of other pituitary hormones. The large As illustrated in the following case study, chromophobe adenoma was removed via making the correct diagnosis of primary ver- a transphenoidal approach. The patient sus secondary hyperthyroidism is imperative has been taken off all medication. Thyroid because the treatment and potential conse- function has returned to normal and there quences of each of these diseases are totally has been no loss of pituitary secretory ca- different. pacity of other pituitary hormones. The oc- currence of a combined TSH- and FSH- Report of case secreting pituitary adenoma is rare; to the In August 1985, a 34-year-old man was seen with authors knowledge, only one case has complaints that were initially vague and nonspe- been documented in the literature. -
A Case of Cushing Syndrome with Both Secondary Hypothyroidism and Hypercalcemia Due to Postoperative Adrenal Insufficiency
Endocrine Journal 2004, 51 (1), 105–113 NOTE A Case of Cushing Syndrome with Both Secondary Hypothyroidism and Hypercalcemia Due to Postoperative Adrenal Insufficiency MASAHITO KATAHIRA, TSUTOMU YAMADA* AND MASAHIKO KAWAI* Department of Internal Medicine, Kyoritsu General Hospital, Nagoya 456-8611, Japan *Division of Endocrinology, Department of Internal Medicine, Okazaki City Hospital, Okazaki 444-8553, Japan Abstract. A 48-year-old woman was referred to our hospital because of secondary hypothyroidism. Upon admission a left adrenal tumor was also detected using computed tomography. Laboratory data and adrenal scintigraphy were compatible with Cushing syndrome due to the left adrenocortical adenoma, although she showed no response to the TRH stimulation test. Hypercortisolism resulting in secondary hypothyroidism was diagnosed. After a left adrenalectomy, hydrocortisone administration was begun and the dose was reduced gradually. After discharge on the 23rd postoperative day, she began to suffer from anorexia. ACTH level remained low, and serum cortisol, free thyroxine and TSH levels were within the normal range. Since her condition became worse, she was re-admitted on the 107th postoperative day at which time serum calcium level was high (15.6 mg/dl). Both ACTH response to the CRH stimulation test and TSH response to the TRH stimulation test were restored to almost normal levels, but there was no response of cortisol to CRH stimulation test. We diagnosed that the hypercalcemia was due to adrenal insufficiency. Although the serum calcium level decreased to normal after hydrocortisone was increased (35 mg/day), secondary hypothyroidism recurred. It was suggested that sufficient glucocorticoids suppressed TSH secretion mainly at the pituitary level, which resulted in secondary (corticogenic) hypothyroidism. -
Clinical Research Protocol
CLINICAL RESEARCH PROTOCOL NCT02399475 The Thyroid Axis in Older Individuals with Persistent Subclinical Hypothyroidism: a Mechanistic, Randomized, Double-Blind, Cross-Over Study of Levothyroxine and Liothyronine Administration Regulatory Sponsor: Anne R. Cappola, MD, ScM Division of Endocrinology, Diabetes, and Metabolism 12-136 Translational Research Center 3400 Civic Center Blvd, Bldg 421 Philadelphia, PA 19104-5160 (215) 573 5359 Funding Sponsor: National Institute on Aging, NIH Medications Used: Thyrotropin Releasing Hormone (TRH) Levothyroxine (LT4) Liothyronine (LT3) Protocol Number: 821564 IND Number: 125167 Initial version:[11/26/2014] Amended [7/22/2015] Amended: [12/18/2014] Amended [9/9/2015] Amended: [1/2/2015] Amended [8/25/2016] Amended: [3/26/2015] Amended [12/23/2016] Amended: [5/13/2015] Amended [3/24/2017] Amended: [06/04/2015] Amended [9/26/2017] Amended: [6/10/2015] Amended [12/18/2017] (additional next page) Amended [12/18/18] CONFIDENTIAL This material is the property of the University of Pennsylvania. Do not disclose or use except as authorized in writing by the study sponsor LT4 and LT3 in Subclinical Hypothyroidism Page ii Version 12/18/2018 Table of Contents STUDY SUMMARY ......................................................................................................... 1 1 INTRODUCTION ...................................................................................................... 3 1.1 BACKGROUND .................................................................................................... -
Anxiety Disorders Resources
Anxiety Disorders Resources (Note: the TDD/TTY telephone numbers are for telecommunication devices for the deaf.) Agoraphobics Building Independent Lives 400 West 32nd Street Richmond, VA 23225 (804) 353-3964 www.anxietysupport.org American Association of Suicidology 5221 Wisconsin Avenue, NW Washington, DC 20015 202-237-2280 National Suicide Prevention Lifeline 1-800-273-TALK (8255) www.suicidology.org American Foundation for Suicide Prevention 120 Wall Street, 22nd floor New York, NY 10005 212-363-3500 888-333-AFSP (2377) Toll-Free www.afsp.org American Psychiatric Association 1000 Wilson Boulevard, Suite 1825 Arlington, VA 22209-3901 703-907-7300 www.psych.org 243 244 ANXIETY DISORDERS RESOURCES American Psychological Association 750 First Street, N.E. Washington, DC 20002-4242 800-374-2721 202-336-5500 TDD/TTY: 202-336-6213 www.apa.org Anxiety Disorders Association of America 8730 Georgia Avenue, Suite 600 Silver Spring, MD 20910 240-485-1001 www.adaa.org Association for Behavioral and Cognitive Therapies 305 Seventh Avenue, 16th floor New York, NY 10001 (212) 647-1890 www.aabt.org Doctors Guide www.docguide.com Freedom from Fear 308 Seaview Avenue Staten Island, NY 10305 718-351-1717 www.freedomfromfear.org International Society for Traumatic Stress Studies 60 Revere Drive, Suite 500 Northbrook IL 60062 847-480-9028 www.istss.org MedlinePlus: Health Information www.medlineplus.gov Mental Health America (formerly National Mental Health Association) 2000 N. Beauregard St., 6t floor Alexandria, VA 22311 800-969-6MHA (6642) 703-684-7722 TTY: 800-433-5959 www.mentalhealthamerica.net ANXIETY DISORDERS RESOURCES 245 National Alliance for the Mentally Ill Colonial Place Three 2107 Wilson Boulevard, Suite 300 Arlington, VA 22201-3042 800-950-NAMI (6264) 703-524-7600 TDD: 703-516-7227 www.nami.org National Anxiety Foundation 3135 Custer Drive Lexington, KY 40517-4001 606-272-7166 National Center for Posttraumatic Stress Disorder U.S. -
The ICD-10 Classification of Mental and Behavioural Disorders Diagnostic Criteria for Research
The ICD-10 Classification of Mental and Behavioural Disorders Diagnostic criteria for research World Health Organization Geneva The World Health Organization is a specialized agency of the United Nations with primary responsibility for international health matters and public health. Through this organization, which was created in 1948, the health professions of some 180 countries exchange their knowledge and experience with the aim of making possible the attainment by all citizens of the world by the year 2000 of a level of health that will permit them to lead a socially and economically productive life. By means of direct technical cooperation with its Member States, and by stimulating such cooperation among them, WHO promotes the development of comprehensive health services, the prevention and control of diseases, the improvement of environmental conditions, the development of human resources for health, the coordination and development of biomedical and health services research, and the planning and implementation of health programmes. These broad fields of endeavour encompass a wide variety of activities, such as developing systems of primary health care that reach the whole population of Member countries; promoting the health of mothers and children; combating malnutrition; controlling malaria and other communicable diseases including tuberculosis and leprosy; coordinating the global strategy for the prevention and control of AIDS; having achieved the eradication of smallpox, promoting mass immunization against a number of other -
Appendix Charles C
APPENDIX CHARLES C. HUGHES GLOSSARY OF 'CULTURE-BOUND' OR FOLK PSYCHIATRIC SYNDROMES INTRODUCTION As suggested by Hughes in his Introduction to this volume, the term "culure bound syndromes" has an elusive meaning; in fact, the several conceptual elements that might imply a focused and exclusive reference for the phrase vanish upon examination, leaving a phrase that still has currency but little discriminable content. What remains appears to be more a feeling tone about certain patterns of behavior so unusual and bizarre from a Western point of view that, regardless of defmitional ambiguities, they have continued to be accorded by some writers a reified status as a different "class" sui generis of psychiatric or putatively psychiatric phenomena. Even if such a unique class were defensible, the topic is beset with sheer nota tional confusion. A reader may wonder, for example, whether terms resembling each other in spelling (e.g., bah tschi, bah-tsi) are reporting different disorders or simply reflecting differences in the authors' phonetic and orthographic tran scription styles for the same disorder. Or perhaps the various renderings are ac curately transcribed but represent dialectical differences in names used for a given syndrome by various groups having the same basic cultural orientation (e.g., win diga, witika, wihtigo, whitigo, wiitika)? In addition, of course, there may be entirely different terms for what is claimed to be essentially the same condition in diverse cultural groups (e.g., karo and shook yang). Dr. Simons noted in the foreword to this book that, as colleagues at Michigan State University over ten years ago, we began to think about such a volume. -
Society for Endocrinology National Clinical Cases 2021
Endocrine Abstracts June 2021 Volume 74 ISSN 1479-6848 (online) Society for Endocrinology National Clinical Cases 2021 22 June 2021, Online published by Online version available at bioscientifica www.endocrine-abstracts.org Volume 74 Endocrine Abstracts June 2021 Society for Endocrinology National Clinical Cases 2021 Tuesday 22 June 2021 Online Meeting Chairs Dr Anna Crown (Brighton) Dr Miles Levy (Leicester) Dr Annice Mukherjee (Manchester) Dr Michael O’Reilly (Dublin) Abstract Marking Panel Dr Kristien Boelart (Birmingham) Dr Karin Bradley (Bristol) Dr Simon Howell (Preston) Dr Andrew Lansdown (Cardiff) Dr Miles Levy (Leicester) Dr Daniel Morganstein (London) Dr Michael O’Reilly (Dublin) Professor Robert Semple (Edinburgh) Dr Peter Taylor (Cardiff) Dr Helen Turner (Oxford) Professor Bijay Vaidya (Exeter) Dr Nicola Zammitt (Edinburgh) Society for Endocrinology National Clinical Cases 2021 CONTENTS Society for Endocrinology National Clinical Cases 2021 Oral Communications ................................................. OC1–OC10 Highlighted Cases ................................................. NCC1–NCC71 AUTHOR INDEX Endocrine Abstracts (2021) Vol 74 Society for Endocrinology National Clinical Cases 2021 Oral Communications Endocrine Abstracts (2021) Vol 74 Society for Endocrinology National Clinical Cases 2021 OC1 lupus-anticoagulant. 5 days post-admission, in view of sudden onset lower A rare heterozygous IGFI variant causing postnatal growth failure and backache & worsening infection markers, repeat CT CAP was done which offering novel insights into IGF-I physiology revealed new bilateral adrenal haemorrhages. MRI adrenals revealed B/l adrenal 1 1 2 1 haemorrhages with fat stranding ,no underlying adrenal mass noted. Her 9am Emily Cottrell , Sumana Chatterjee , Vivian Hwa & Helen L. Storr ! 1 cortisol was 25, therefore she was started on IV hydrocortisone for acute Centre for Endocrinology, William Harvey Research Institute, Barts and adrenal insufficiency. -
Clinical Manual of Cultural Psychiatry
Clinical Manual of Cultural Psychiatry Second Edition This page intentionally left blank Clinical Manual of Cultural Psychiatry Second Edition Edited by Russell F. Lim, M.D., M.Ed. Washington, DC London, England Note: The authors have worked to ensure that all information in this book is accurate at the time of publication and consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate at the time of publication and consistent with standards set by the U.S. Food and Drug Administration and the general medical community. As medical research and practice continue to advance, however, therapeutic standards may change. Moreover, specific situations may require a specific therapeutic response not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family. Books published by American Psychiatric Publishing (APP) represent the findings, conclusions, and views of the individual authors and do not necessarily represent the policies and opinions of APP or the American Psychiatric Association. If you would like to buy between 25 and 99 copies of this or any other American Psychiatric Publishing title, you are eligible for a 20% discount; please contact Customer Service at [email protected] or 800-368-5777. If you wish to buy 100 or more copies of the same title, please e-mail us at [email protected] for a price quote. Copyright © 2015 American Psychiatric Association ALL RIGHTS RESERVED Manufactured in the United States of America on acid-free paper 181716151454321 Proudly sourced and uploaded by [StormRG] Second Edition Kickass Torrents | TPB | ET | h33t Typeset in Adobe Garamond and Helvetica. -
Psychopathology & Abnormal Psychology
PsychopathologyPsychopathology && AbnormalAbnormal PsychologyPsychology WeWe havehave talkedtalked aboutabout individualindividual differencesdifferences inin personality,personality, abilities,abilities, etc.,etc., butbut somesome individualindividual differencesdifferences gogo beyondbeyond thethe rangerange ofof normalnormal functioningfunctioning andand areare usuallyusually calledcalled psychologicalpsychological disordersdisorders JustJust howhow toto definedefine psychopathologypsychopathology isis thethe subjectsubject ofof somesome disagreementdisagreement Is it simply statistically infrequent behavior? Violation of social norms? Behavior that produces personal distress? Maladaptive or dysfunctional behavior? PsychologicalPsychological disordersdisorders generallygenerally fitfit severalseveral ofof thesethese criteriacriteria ClassificationClassification schemesschemes ThreeThree categoriescategories (up(up untiluntil aboutabout 2525 yrsyrs ago)ago) Organic brain syndromes Neurosis : any disorder characterized by conflict and anxiety that cause distress and impair a person ’s functioning but don ’t render him/her incapable of coping with external reality (e.g., phobias, panic disorder, obsessive -compulsive disorder, etc.) Psychosis : any disorder characterized by severely disordered thought or perception to the point of a break with reality (e.g., schizophrenia, bipolar disorder) Examples ClassificationClassification schemesschemes TheThe currentcurrent emphasisemphasis isis onon clear,clear, observableobservable -
An Access-Dictionary of Internationalist High Tech Latinate English
An Access-Dictionary of Internationalist High Tech Latinate English Excerpted from Word Power, Public Speaking Confidence, and Dictionary-Based Learning, Copyright © 2007 by Robert Oliphant, columnist, Education News Author of The Latin-Old English Glossary in British Museum MS 3376 (Mouton, 1966) and A Piano for Mrs. Cimino (Prentice Hall, 1980) INTRODUCTION Strictly speaking, this is simply a list of technical terms: 30,680 of them presented in an alphabetical sequence of 52 professional subject fields ranging from Aeronautics to Zoology. Practically considered, though, every item on the list can be quickly accessed in the Random House Webster’s Unabridged Dictionary (RHU), updated second edition of 2007, or in its CD – ROM WordGenius® version. So what’s here is actually an in-depth learning tool for mastering the basic vocabularies of what today can fairly be called American-Pronunciation Internationalist High Tech Latinate English. Dictionary authority. This list, by virtue of its dictionary link, has far more authority than a conventional professional-subject glossary, even the one offered online by the University of Maryland Medical Center. American dictionaries, after all, have always assigned their technical terms to professional experts in specific fields, identified those experts in print, and in effect held them responsible for the accuracy and comprehensiveness of each entry. Even more important, the entries themselves offer learners a complete sketch of each target word (headword). Memorization. For professionals, memorization is a basic career requirement. Any physician will tell you how much of it is called for in medical school and how hard it is, thanks to thousands of strange, exotic shapes like <myocardium> that have to be taken apart in the mind and reassembled like pieces of an unpronounceable jigsaw puzzle. -
Volume 11 Number 4 December 2007 EDITORS ASSOCIATE EDITORS
Mpcp_11_4_Cover.qxp 11/13/07 12:37 PM Page 1 International Journal of Psychiatry in Clinical Practice 261–344 11 Number 4 December 2007 Pages Volume Volume 11 Number 4 December 2007 EDITORS CONTENTS David Baldwin Editorial Case Report Siegfried Kasper Original Articles Topiramate-induced psychotic exacerbation Evaluation of traumatic events EH Karsliogˇlu, H Karakiliç, E Taner BN Axelrod, J Grabowski and ASSOCIATE and B Cos¸ar EDITORS L Trewhella Screening for depression in a diabetic Short Report outpatient population Questionnaire on animal-assisted Robert Hirschfeld EJ Daly, MH Trivedi, P Raskin and therapy Shigeto Yamawaki BD Grannemann K Iwahashi, C Waga and M Ohta Risperidone in adolescent psychoses Book Review M Hrdlicka and I Dudova Abstracts Pilot of group intervention for bipolar disorder Volume Index D Castle, M Berk, L Berk, S Lauder, J Chamberlain and M Gilbert www.tandf.no/ijpcp ISSN 1365-1501 Mpcp_11_4_Cover.qxp 11/12/07 9:13 PM Page 2 INSTRUCTIONS FOR AUTHORS (www.tandf.no/ijpcp) SCOPE AND POLICY ILLUSTRATIONS International Journal of Psychiatry in Clinical Practice (IJPCP) is a high All illustrations should be uploaded as TIFF or high resolution quality quarterly journal targeted primarily at clinical psychiatrists (min.300 dpi) JPEG format. All illustrations (including line drawings working in hospital environments as well as in private practice. and photographs) should be referred to in the text as ‘Figure 1’, Particular emphasis is placed on the interface between important new ‘Figures 1–4’, using Arabic numbers. Each figure must be cited in the treatments stemming from advanced scientific research and their clinical text. -
Central Hypothyroidism in Miniature Schnauzers
J Vet Intern Med 2016;30:85–91 Central Hypothyroidism in Miniature Schnauzers Annemarie M.W.Y. Voorbij, Peter A.J. Leegwater, Jenny J.C.W.M. Buijtels, Sylvie Daminet, and Hans S. Kooistra Background: Primary hypothyroidism is a common endocrinopathy in dogs. In contrast, central hypothyroidism is rare in this species. Objectives: The objective of this article is to describe the occurrence and clinical presentation of central hypothyroidism in Miniature Schnauzers. Additionally, the possible role of the thyroid-stimulating hormone (TSH)-releasing hormone recep- tor (TRHR) gene and the TSHb (TSHB) gene was investigated. Animals: Miniature Schnauzers with proven central hypothyroidism, based on scintigraphy, and the results of a 3-day- TSH-stimulation test, or a TSH-releasing hormone (TRH)-stimulation test or both, presented to the Department of Clinical Sciences of Companion Animals at Utrecht University or the Department of Medicine and Clinical Biology of Small Animals at Ghent University from 2008 to 2012. Methods: Retrospective study. Pituitary function tests, thyroid scintigraphy, and computed tomography (CT) of the pitui- tary area were performed. Gene fragments of affected dogs and controls were amplified by polymerase chain reaction (PCR). Subsequently, the deoxyribonucleic acid (DNA) sequences of the products were analyzed. Results: Central hypothyroidism was diagnosed in 7 Miniature Schnauzers. Three dogs had disproportionate dwarfism and at least one of them had a combined deficiency of TSH and prolactin. No disease-causing mutations were found in the TSHB gene and the exons of the TRHR gene of these Schnauzers. Conclusions and clinical importance: Central hypothyroidism could be underdiagnosed in Miniature Schnauzers with hypothyroidism, especially in those of normal stature.