November 8, 2012

National Lab Day in Mississippi National User Facilities – Driving American Innovation

Horst Simon Deputy Laboratory Director Lawrence Berkeley National Laboratory

Oxford, Mississippi November 8, 2012

National Lab Day in Mississippi Origins of the First User Facilities

Ernest O. Lawrence Lawrence’s original November 1, 1937 5-inch cyclotron, 80 keV, 1931

3 National Lab Day in Mississippi National User Facilities – Driving American Innovation Lawrence’s Big Team Science in 1931

4 National Lab Day in Mississippi National User Facilities – Driving American Innovation DOE National Scientific User Facilities Today

5 National Lab Day in Mississippi National User Facilities – Driving American Innovation World Class User Facilies at the Naonal Labs

Pacific Northwest National Laboratory Argonne National Laboratory • Advanced Photon Source • Environmental Molecular Sciences Lawrence Berkeley National • Center for Nanoscale Materials Laboratory Laboratory • Electron Microscopy Center Brookhaven National Laboratory • Atmospheric Radiation • Advanced Light Source • Argonne Leadership Computing • Center for Functional Nanomaterials Measurement Climate Research • Molecular Foundry Facility • National Synchrotron Light Source • National Center for Electron Microscopy • Argonne Tandem Linac Accelerator • National Synchrotron Light Source II • National Energy Research Scientific System • Relativistic Heavy Ion Collider Computing Center • Joint Genome Institute • Energy Sciences Network

SLAC National Accelerator Laboratory Oak Ridge National Laboratory • Linac Coherent Light Source • Center for Nanophase Materials Sciences • High Flux Isotope Reactor • Stanford Synchrotron Radiation Lightsource • Shared Research Equipment Facility • Spallation Neutron Source • Facility for Advanced Accelerator Experimental Tests • Oak Ridge Leadership Computing Facility • Holifield Radioactive Ion Beam Facility

Sandia National Laboratory Los Alamos National Laboratory • Core Facility for Center for Integrated • Gateway Facility for Center for Integrated Nanotechnologies Nanotechnologies • Manuel Lujan Jr. Neutron Scattering Center

6 National Lab Day in Mississippi National User Facilities – Driving American Innovation DOE’s Office of Science, by the Numbers

• $5B budget, annually supporting:

− 25,000 Ph.D. scientists, graduate students, under-graduates, engineers, and technical staff at more than 300 institutions in all 50 States and DC through competitive awards

− 26,000 users at 32 national scientific user facilities

• 100 Nobel Prizes during the past 6 decades—more than 20 in the past 10 years

7 National Lab Day in Mississippi National User Facilities – Driving American Innovation Using National Scientific Facilities

science.energy.gov/user-facilities/

8 National Lab Day in Mississippi National User Facilities – Driving American Innovation Using National Scientific Facilities

• Open to all • Time competitively awarded • No user fees for non-proprietary work • Support for users • User organizations to facilitate collaborations • Does not compete with private sector

9 National Lab Day in Mississippi National User Facilities – Driving American Innovation Structural Biology Users 4 Nobel Prizes in 9 Years with Light Sources

• 2012 Prize in Chemistry: Robert Lefkowitz and Brian Kobilka, “for studies of G-protein-coupled receptors.” Used Stanford Synchrotron Radiation Lightsource, the Advanced Photon Source and the Advanced Light Source.

• 2009 Prize in Chemistry: Venkatraman Ramakrishnan, Thomas Steitz, and Ada Yonath) “for studies of the structure and function of the ribosome.” Used all four light sources.

• 2006 Prize in Chemistry: Roger Kornberg "for his studies of the molecular basis of eukaryotic transcription.” Used Stanford Synchrotron Radiation Lightsource and the Advanced Light Source.

• 2003 Prize in Chemistry: Roderick MacKinnon for “structural and mechanistic studies of ion channels.” Used National Synchrotron Light Source.

10 National Lab Day in Mississippi National User Facilities – Driving American Innovation Industrial Users: X-ray, Neutron, Electron Scattering and High-Performance Computing

11 National Lab Day in Mississippi National User Facilities – Driving American Innovation Maintaining U.S. Innovation Leadership

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12 National Lab Day in Mississippi National User Facilities – Driving American Innovation