Berlin-Buch Research Report 2006 (Covers the Period 2004-2005)
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Research Report 2006 MDC Max Delbrück Center for Molecular Medicine Berlin-Buch Research Report 2006 (covers the period 2004-2005) Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch Robert-Rössle-Str. 10 D-13125 Berlin Tel.: +49-30-9406-0 Fax: + 49-30-949-4161 e-mail: [email protected] This Research Report is also available on the World Wide Web http://www.mdc-berlin.de The MDC is a member of the Helmholtz Association of National Research Centers. The following Research Reports have been published previously: Research Report 1996 (covers the period 1992-1995) Research Report 1996/97 (covers the period 1996-1997) Research Report 2000 (covers the period 1998-1999) Research Report 2002 (covers the period 2000-2001) Research Report 2004 (covers the period 2002-2003) Editor-in-Chief Pamela Cohen Editorial Board Barbara Bachtler Walter Birchmeier Carmen Birchmeier-Kohler Udo Heinemann Helmut Kettenmann Achim Leutz Christina Quensel Jens Reich Ludwig Thierfelder Thomas Willnow Coordination Lydia Klinger Elisabeth Kujawa-Schmeitzner Ann-Kathrin Schöpflin Book Design Hoch Drei GmbH, 10963 Berlin Photos David Ausserhofer (16, 20, 22, 36, 39, 41, 43, 46, 48, 50, 53, 56, 59, Legend to Cover Figure: 61, 63, 66, 68, 80, 84, 86, 88, 91, 97, 100, 103, 104, 105, 107, 109, 111, 113, 116, 118, 120, 123, 127, 130, 133, 135, 137, 140, 142, 144, A human protein-protein interaction map 146, 148, 150, 157, 160, 162, 164, 169, 173, 175, 177, 179, 181) (this report page 170) Klaus Lehmann (25) Graph representation of 3,186 putative interactions Privat (27, 31, 34, 167, 188) between 1,705 different human proteins (drawn Printing using the Pajek program package). Reprinted from Brandenburgische Universitätsdruckerei Cell 122 Vol. 6, Stelzl et al. A human protein- und Verlagsgesellschaft Potsdam mbH protein interaction network: a novel resource for annotating the proteome. 957-968, Copyright Printed in Germany 2006 (2005), with permission from Elsevier. Research Report 2006 Covers the period 2004/2005 2 Content Inhalt Foreword Vorwort ................................................................................................................................................................ 7 Cardiovascular and Metabolic Diseases Herz-Kreislauf- und Stoffwechselerkrankungen ............................................................................................ 12 Hypertension, Vascular Disease, and Kidney Disease Molecular Cardiovascular Research Thomas E. Willnow ................................................................................................... 16 Molecular Biology of Peptide Hormones Michael Bader .......................................................................................................... 20 Hypertension, Vascular Disease, Genetics, and Nephrology Friedrich C. Luft ....................................................................................................... 22 Cytochrome P450-dependent Eicosanoids in the Regulation of Cellular and Organ Function Wolf-Hagen Schunck ............................................................................................... 25 Smooth Muscle Cell Electrophysiology, Ion Channel, and Transporter Function Maik Gollasch (Helmholtz Fellow) .............................................................................. 27 Cardiovascular and Metabolic Regulation Jens Jordan ............................................................................................................. 31 Functional Characterization of Newly Identified Human Importin α Proteins Matthias Köhler (Helmholtz Fellow) ........................................................................... 34 Mechanisms of Hypertension-induced Target Organ Damage Dominik N. Müller (Helmholtz Fellow) ........................................................................ 36 Heart Disease Cardiovascular Molecular Genetics Ludwig Thierfelder .................................................................................................... 39 Genetic Disorders of the Cardiovascular System Brenda Gerull (Helmholtz Fellow) .............................................................................. 41 Myocardial Regeneration and Heart Failure Rainer Dietz ............................................................................................................. 43 Cardiovascular Magnetic Resonance Jeanette Schulz-Menger ........................................................................................... 46 Myocardial Signal Transduction in Heart Failure Martin W. Bergmann ................................................................................................ 48 Molecular Muscle Physiology Ingo L. Morano ........................................................................................................ 50 3 Cell Polarity and Epithelial Formation Salim Abdelilah-Seyfried ........................................................................................... 53 Molecular and Cell Biology of the (Epi)genome M. Cristina Cardoso ................................................................................................. 56 Immunology of Cardiovascular Diseases Gerd Wallukat .......................................................................................................... 59 Neuromuscular and Cardiovascular Cell Biology Michael Gotthardt .................................................................................................... 61 Metabolic Diseases, Genetics, Genomics, and Bioinformatics Bioinformatics Jens Reich ............................................................................................................... 63 Medical Genomics and Gene Mapping Center Norbert Hübner ........................................................................................................ 66 Genetics of Atopic Disease Young-Ae Lee .......................................................................................................... 68 Cancer Research Krebsforschungsprogramm ............................................................................................................................. 72 Signalling Pathways, Cell Biology, and Cancer Epithelial Signal Transduction, Invasion, and Metastasis Walter Birchmeier ..................................................................................................... 80 Genetics of Tumor Progression and Metastasis Ulrike S. Ziebold (funded by a Marie-Curie Excellence Grant) .................................... 84 Signaling Mechanisms in Embryonic Stem Cells Daniel Besser (Helmholtz Fellow) .............................................................................. 86 Surgical Oncology Peter M. Schlag ....................................................................................................... 88 Molecular Genetics of Cell Differentiation & Tumorigenesis Achim Leutz ............................................................................................................. 91 Cancer Stem Cells and Transcription Factors Frank Rosenbauer (Helmholtz Fellow) ....................................................................... 95 Signal Transduction in Tumor Cells Claus Scheidereit ..................................................................................................... 97 Intracellular proteolysis Thomas Sommer ................................................................................................... 100 Regulation of Nuclear Transport Processes Katrin Stade (Helmholtz Fellow) .............................................................................. 103 Post-Translational Modifications Gunnar Dittmar ...................................................................................................... 104 Control of DNA Replication Manfred Gossen ..................................................................................................... 105 4 Nuclear Signalling and Chromosome Structure Harald Saumweber ................................................................................................ 107 Evolution, Regulation and Genetic Applications of Transposable Elements in Vertebrates Zoltán Ivics ............................................................................................................. 109 Mobile DNA Elements in Vertebrates Zsuzsanna Izsvák ................................................................................................... 111 Structural and Functional Genomics Macromolecular Structure and Interaction Udo Heinemann ..................................................................................................... 113 Computer Simulation of Biomolecular Structures, Dynamics, and Interactions Heinz Sklenar ......................................................................................................... 116 Nucleoside Analogs as Inhibitors of HBV and HCV Replication Eckart Matthes ....................................................................................................... 118 Tumor Genetics Siegfried Scherneck ............................................................................................... 120 Tumor Immunology Differentiation and Growth Control in Lymphocyte Development and Immunopathogenesis Martin Lipp ............................................................................................................. 123 Biology and Targeted Therapy of Lymphoma Bernd Dörken ........................................................................................................ 127 Molecular Mechanisms