MSKCC 2012 Annual Report

Memorial Sloan-Kettering Cancer Center

2012 ANNUAL REPORT

A SHARED VISION A SINGULAR MISSION

Nurse practitioner Naomi Cazeau, of the Adult Bone Marrow Transplant Service. PING CHI PHYSICIAN-SCIENTIST 10

STEPHEN SOLOMON ALEXANDER RUDENSKY INTERVENTIONAL IMMUNOLOGIST RADIOLOGIST 16 12

VIVIANE TABAR The clinicians and scientists of NEUROSURGEON Memorial Sloan-Kettering share a vision and 18 a singular mission — to conquer cancer. STEPHEN LONG STRUCTURAL BIOLOGIST They are experts united against a 20 SIMON POWELL complex disease. Each type of cancer R ADIATION ONCOLOGIST 24 ETHEL LAW is different, each tumor is unique. Set free NURSE PRACTITIONER in surroundings that invite the sharing of 26 ideas and resources, they attack the

CHRISTINA LESLIE complexity of cancer from every angle COMPUTATIONAL BIOLOGIST and every discipline. 34

SCOTT ARMSTRONG PEDIATRIC ONCOLOGIST 30

TO JORGE REIS-FILHO EXPERIMENTAL PATHOLOGIST CONQUER 38 CANCER 04  Letter from the Chairman and the President A complete version of this report — 42 Statistical Profile which includes lists of our donors, 44 Financial Summary doctors, and scientists — 46 Boards of Overseers and Managers is available on our website at 49  The Campaign for Memorial Sloan-Kettering www.mskcc.org/annualreport. 4 5

Letter from the Chairman In 2012 the leadership of Memorial Sloan-Kettering endorsed Douglas A. Warner III These programmatic investments require leadership and and the President a $2.2 billion investment in a clinical expansion that will set vision. Our new Physician-in-Chief, José Baselga, joined the stage for a changing care paradigm into the next decade us on January 1, 2013. An internationally recognized and beyond. physician-scientist, he comes to us from Massachusetts General Hospital (MGH) where he was Chief of the This decision occurred against a backdrop of strong Division of Hematology/Oncology and Associate Director financial results, new clinical leadership, and new of the MGH Cancer Center. Dr. Baselga is no stranger to collaborative relationships. These actions position MSKCC. He completed a medical oncology fellowship at Memorial Sloan-Kettering for a future in which we have Memorial Hospital and remained as a faculty member on the every reason to believe we will witness historic progress Chairman Breast/Gynecology Service from 1994 through 1996, after against the complex set of diseases we know as cancer. Boards of Overseers and Managers which he returned to his native Spain. His responsibilities include the management of patient care delivery in Memorial There are several tangible components of the clinical Hospital as well as at MSKCC clinics and regional sites. strategic plan, among them an outpatient cancer care Dr. Baselga will also focus on clinical strategic planning and building that we plan to develop along the FDR Drive at East Craig B. Thompson will oversee clinical and translational research. He succeeds 74th Street in conjunction with Hunter College of the City Physician-in-Chief Robert E. Wittes, who stepped down after University of New York. The project, currently under review a decade of exemplary service. by city planning authorities, would enable us to provide cancer care in a facility designed to adapt to the ways in Thomas J. Kelly, Director of the Sloan-Kettering Institute which cancer will be diagnosed and treated in the coming for the past 11 years, announced that he would be decades. We will provide leading-edge treatment for patients stepping down as of March 1, 2013. He is returning to with hematologic cancers such as leukemia and lymphoma, full-time research and will remain an SKI faculty member. head and neck cancers, and thoracic cancers. In addition, Dr. Kelly joined MSKCC in early 2002 and led the largest the facility will support our efforts to provide bone marrow President and expansion in SKI’s history to broaden the scope of its Chief Executive Officer transplants in the outpatient setting and provide a focused basic and translational research activities and focus on the environment for early-stage clinical trials. The MSKCC most promising areas of biomedical research as they building would be located next to the future home of Hunter relate to cancer. A search committee is actively recruiting College’s new Science and Health Professions building and his successor. its School of Nursing. The acquisition contract is contingent upon the necessary land use and zoning actions required for We are pleased with our financial results for 2012, construction of the two proposed buildings. particularly because our operating results for 2011 included non-recurring prior year gains. Our clinical volume continues Other elements of the capital program include the Josie to expand and, in a sign of our strength as an organization, Robertson Surgical Center on York Avenue, which MSKCC was able to issue 40-year taxable debt at attractive will feature 12 operating rooms equipped to provide rates — the ­first such issuance by a not-for-profit. These technologically sophisticated surgical care on an outpatient and other bond financings will be used for the major clinical basis. The certificate of need was approved in 2012, the expansion program that is currently under way. structure that was on the site has been demolished, and construction has begun. Also close to the main campus, At MSKCC’s 33rd annual Academic Convocation in May, MSKCC is planning a new facility that will house a clinical we celebrated an important milestone when the first four laboratory and research building and will accommodate graduates of the Louis V. Gerstner, Jr. Graduate School all specialized testing, along with a cell bank, a cell of Biomedical Sciences received their PhD degrees. The therapy facility, and tumor procurement services. Regional school admitted its first class of six students in 2006 and investments include a 114,000-square-foot ambulatory has become one of the premier training grounds for cancer care facility in Harrison, New York, that will offer biology and a model for training biomedical scientists. advanced cancer care to area residents, closer to home. Today, more than 50 students are engaged in thesis work in A “topping-off” ceremony took place on December 20 as the laboratories of our faculty. Six more students will the final steel beam of the structure was hoisted into place. graduate in May 2013. 6 7

In a striking example of the integration of clinical studies In December, President Obama appointed Charles Sawyers and fundamental laboratory discoveries at MSKCC, the US as one of six new members of the National Cancer Food and Drug Administration announced in August that the Advisory Board (NCAB). Dr. Sawyers will serve on a drug enzalutamide had been approved for the treatment of body that advises on some of our nation’s most pressing The dedication, men with metastatic prostate cancer. The results of a large, issues in cancer research and treatment. In yet another energy, compassion, multicenter phase III study, led by an MSKCC physician- honor, Dr. Sawyers was elected President of the American and creative spirits scientist, showed that enzalutamide significantly increased Association for Cancer Research, the world’s oldest and survival in men with advanced disease. Investigators led by John R. Gunn largest professional organization dedicated to advancing of the men and women of Howard I. Scher, Chief of MSKCC’s Genitourinary Oncology Executive Vice President cancer research. Memorial Sloan-Kettering Service, first presented these findings at the American are what power this Society of Clinical Oncology’s Genitourinary Cancers And Clifford A. Hudis, Chief of the Breast Cancer Medicine extraordinary institution Symposium in February 2012. Laboratory work conducted Service, was elected President of the American Society and make us thrive.” by Charles L. Sawyers, Chair of our Human Oncology and of Clinical Oncology, the world’s leading professional Pathogenesis Program, and colleagues was instrumental in organization representing more than 30,000 physicians who the development of this novel therapy. The basic research care for people with cancer. that resulted in its development, and the collaborative efforts Robert E. Wittes to bring that discovery into a clinical setting, will serve as a Physician-in-Chief, The many achievements and successes over the past year model for future drug development at academic institutions. Memorial Hospital would have been impossible without the support of our staff, who performed exceptionally in every important area. The excellence of our researchers and research community The dedication, energy, compassion, and creative spirits of received a ringing endorsement from The Starr Foundation, the men and women of Memorial Sloan-Kettering are what which provided renewed support for The Starr Cancer power this extraordinary institution and make us thrive. Consortium and Tri-Institutional Stem Cell Initiative totaling $105 million. The Starr Cancer Consortium is a collaboration In the pages that follow, you will meet ten MSKCC among MSKCC, the Broad Institute of Harvard and MIT, researchers — basic scientists and clinicians — all of whom The Rockefeller University, Weill Cornell Medical College, Thomas J. Kelly are working to answer critical questions about cancer. Each Director, and Cold Spring Harbor Laboratory. The Tri-Institutional Sloan-Kettering Institute one is making seminal contributions to the development of Stem Cell Initiative is a collaboration among MSKCC, The new and innovative therapies that will improve and prolong Rockefeller University, and Weill Cornell Medical College. the lives of the patients we see today and those we will care for tomorrow. Our clinicians and scientists received numerous awards and honors in 2012, far more than we could ever mention here, so we will single out just a few of the most significant. Structural Biology Program Chair Nikola Pavletich and Immunology Program Chair Alexander Rudensky were named members James D. Robinson III of the National Academy of Sciences (NAS). The NAS is one Honorary Chairman, of our country’s most prestigious scientific societies and Boards of Overseers and Managers Douglas A. Warner III Craig B. Thompson election to its membership is one of the highest honors given Chairman, Boards of Overseers President and to scientists working in the United States. Drs. Pavletich and and Managers Chief Executive Officer Rudensky join the ten MSKCC researchers who were already NAS members.

In addition, neuro-oncologist Lisa M. DeAngelis was elected to the Institute of Medicine (IOM). Dr. DeAngelis is Chair of MSKCC’s Department of Neurology and Co-Executive Director of the Brain Tumor Center. Election to the IOM is considered one of the highest honors in the fields of health and medicine. She joins MSKCC’s 17 other IOM members. 8 9 Focused

Collaborative Committed Driven

Creative

Compassionate

Innovative United

WE ARE MSKCC Inquisitive Insightful

Supportive 10 11

cancer and may represent a specific Achilles’ heel for a certain cancer type that we may be able to target with drugs. My lab is using many different approaches to look for novel diagnostic and prognostic biomarkers and targets in sarcomas. These include mapping epigenetic changes, studying the cells of different types of sarcomas and the formation of disease in mouse models, and using high-throughput screens, which can evaluate gene expression signatures in thousands of samples at the same time. Even Dr. Chi meets with a patient. though we have come very far with targeted therapy, we still have a poor understanding of the biology of many types of sarcoma, and we don’t have a lot of treatment options. A new focus of my lab is studying something called malignant peripheral nerve sheath tumors. When I began looking for a place to start The only treatment that can cure my career, I was drawn to Memorial these tumors is surgery, and the Ping Chi, MD, PhD surgery is very difficult because Sloan-Kettering’s Human Oncology and the tumors often surround crucial MEDICAL ONCOLOGIST, nerves. So I’m trying to identify MELANOMA AND Pathogenesis Program [HOPP] because SARCOMA SERVICE I believed it would give me sufficient ways to develop targeted therapy for CANCER BIOLOGIST, advanced tumors. Understanding HUMAN ONCOLOGY AND time to focus on my lab research without their genetic alterations could lead PATHOGENESIS PROGRAM to the development of clinical trials GEOFFREY BEENE JUNIOR having to give up caring for patients. in which drugs or combinations of FACULTY CHAIR drugs are selected to work against a HOPP was founded to bring together diverse group of tumors that arise in particular target. a diverse group of physician-scientists soft tissues such as muscle, fat, and One of my goals is to get more who could advance scientific knowledge cartilage, and in bones.] involved with early-stage clinical while moving laboratory discoveries I am looking at genetic changes trials that exploit the same molecular more rapidly into the clinic. such as mutations, which affect the mechanisms I’m studying in the lab. HOPP researchers tend to ask sequence of DNA [our genetic code], In particular, for patients with a rare questions about the molecular and also epigenetic changes, which gastrointestinal tumor called GIST, causes of cancer. And although do not involve alterations in our there is a new treatment strategy we work primarily in the lab, we genetic code but can control whether that targets a gene called ETV1 meet regularly with our physician a gene is turned on or off. and potentially could be used as an colleagues to discuss new cases, so we I also study the cellular alternative to and a more effective never lose sight of the practical and context in which genetic and therapy than the current therapy, clinical considerations that go in to epigenetic changes occur. This is a drug called imatinib (Gleevec®), making decisions about patient care. important in my research because which targets a different gene. My Ping As a clinician, I see patients sometimes — depending on the colleagues and I hope to start a with melanoma and many different signals that are activated by nearby clinical trial for this new treatment types of sarcomas. [Sarcomas are a cells — such changes can lead to strategy sometime in 2013. 12 13

Interventional radiologists are physicians who use image guidance — including CT and PET scans, ultrasound, x-rays, and MRI scans — to perform minimally invasive procedures that diagnose and treat disease and provide relief from symptoms. Thermal ablation of a tumor is among the procedures we do routinely. The technique involves placing a needle into a tumor and applying extreme heat or cold to kill the cancer while preserving surrounding healthy tissue. This has traditionally been done under CT guidance, which allows us to Interventional radiology (IR) is an visualize the tumor and know where increasingly common approach to diagnosing to place the needle. But the CT and treating cancer. The use of image-guided image can’t tell us whether we have fully destroyed a tumor. interventions at MSKCC has grown to A method that could provide approximately 12,000 cases annually, and my real-time, image-based monitoring of tumor ablation would be a colleagues and I are engaged in numerous valuable tool. MSKCC is one of multidisciplinary, image-guided clinical and the only hospitals in the world with an interventional PET-CT, research initiatives. which is housed in our Center for Image-Guided Interventions. We’re investigating a novel, Steve MSKCC-developed way to use PET scans to assess — while a patient is still on the table — whether we have completely ablated a tumor. In addition to destroying tumors, thermal ablation may also help activate tumor-specific T cells [a type of immune cell]. When we ablate a tumor, we create an inflammatory Stephen B. Solomon, MD reaction in which these cells are recruited to clean up the dead cancer CHIEF, INTERVENTIONAL RADIOLOGY SERVICE cells. In the process, the T cells have the opportunity to learn that the DIRECTOR, CENTER FOR IMAGE-GUIDED INTERVENTIONS cancer has certain markers that they might be able to recognize in order to fight cancer that has spread to other parts of the body. Generally, though, after ablation the immune response in humans is weak and not sufficient Dr. Solomon with his colleague, interventional radiologist to eradicate tumors elsewhere in Constantinos I. Sofocleous (foreground), the body or to prevent disease in an interventional radiology control room during an IR procedure. progression. However, what we’ve discovered in our research in mice 14 15

is that when we give a drug called ipilimumab (Yervoy™) after tumor ablation we can boost the immune (Below, from left) Drs. Sofocleous system and see a response at other and Solomon collaborate on an IR procedure; (at right) Dr. Solomon meets sites in the animal’s body. We’re now with a patient before beginning an investigating this approach with a IR procedure. variety of cancers and with several different drugs; and, in collaboration with colleagues on the Breast Cancer Medicine Service, we’ve begun a small clinical study in women with localized breast cancer. We are looking at applying this technique to other cancers as well. Another area of investigation in our group involves a new ablation tool called irreversible electroporation (IRE), which does not use heat or cold to kill cancer cells. This technique uses an electrical current to punch holes in cell walls, irreversibly destroying the cells. Some organs, such as blood vessels, are not made up of just cells — there’s necessary studies, larger amounts also a protein structure. Because of tissue are required than in the IRE targets only cells, we may be past. One of the things we do as able to target a tumor abutting a interventional radiologists is to major blood vessel, killing the cancer obtain tumor samples by doing cells while the vessel wall — because needle biopsies. We currently have a it’s made up of these structural major initiative to develop innovative proteins — remains intact. ways to determine — during a needle MSKCC interventional biopsy — when we have collected radiologists also can treat certain enough tissue. One technology we’re liver tumors by blocking branches in the preliminary stages of exploring of the hepatic artery in a procedure is spectral analysis, which involves called embolization. With their shining a special light on a specimen blood supply cut off, the tumors as soon as it’s removed from a patient die. We have expanded our use of to allow us to see whether we have the technique to include treatments enough cells in the sample. for liver cancer using beads that With so much progress in the deliver chemotherapy or radiation field of interventional radiology directly to tumors. The beads we’ve also established an Oncologic combine the therapeutic effects of Interventional Radiology Fellowship radiation or chemotherapy with those in which fellows are exposed to the of embolization. full range of interventions and which In light of recent advances in also includes time to pursue research. individualized therapy for many These are just a few examples of types of cancer, molecular profiling the ways in which our IR group is of tumors is vital for guiding working to enhance and improve the treatment decisions. To perform the care we provide to patients. 16 17

the Foxp3 gene is essential for the process by which extrathymic regulatory T cells — those regulatory T cells that are generated outside of the thymus — mature and acquire Our immune system has evolved highly specialized traits and functions. In one of our studies, published sophisticated ways of fighting infection in the journal Cell in July 2012, that hinge on its ability to distinguish we discovered that one unique function of these cells is to between healthy cells and cells harboring control the immune system during intruders such as viruses. pregnancy. Our findings suggest that extrathymic development of This system provides powerful pathways underlie their ability to regulatory T cells emerged during protection against pathogens, but it regulate the immune system — has evolution to prevent a mother’s comes at a price: Unless the different many potential clinical applications. immune system from attacking the cell types of the immune system For example, numerous studies fetus. In mice that lack the are controlled precisely, they may have shown that most tumors are aforementioned Foxp3 DNA element, inflict severe damage on the body’s infiltrated by regulatory T cells, extrathymic regulatory T cells own cells and tissues. which are believed to suppress do not develop normally, causing My laboratory studies immune responses to cancer. Drugs pregnant females to lose their T lymphocytes, white blood cells that act by inhibiting regulatory T embryos more frequently and develop that are vital in the immune cell function might offer new and complications reminiscent of those system’s response to infection. effective ways to control the disease. seen in human pregnancies. One of the areas we focus on Other potential therapies that act In another study, published is a subset of T lymphocytes called by boosting or targeting these cells in Nature in February 2012, we regulatory T cells. We’ve found that are being explored to treat conditions found that extrathymic regulatory regulatory T cells are critical for characterized by an overactive immune T cells control allergic and asthma- keeping other white blood cells in system — including autoimmune like inflammation in the gut and Alexander Y. Rudensky, PhD check, thereby playing an important disorders such as rheumatoid lungs. My colleagues and I are role in controlling immune arthritis, psoriasis, and diabetes. now exploring whether subsets of CHAIR, IMMUNOLOGY PROGRAM, system reactions. In the absence Previously, we and others found regulatory T cells generated in and SLOAN-KETTERING INSTITUTE Foxp3 of regulatory T cells, instead of that a gene called plays a outside of the thymus play a role in HOWARD HUGHES different types of cancer. MEDICAL INSTITUTE INVESTIGATOR We biologists tend to study an organism by breaking it down into parts — essentially attempting to reduce it to a mechanism. And it used to be that immunologists focused largely on specific parts of the immune system, overlooking its entirety and the interactions that take place between the immune, endocrine, Dr. Rudensky in his laboratory. and nervous systems. Working with MSKCC clinicians, we are now starting to apply our knowledge attacking foreign cells, the immune critical role in the generation of about the ways regulatory T cells system attacks normal cells and regulatory T cells both in and outside control multiple body functions to tissues, which may lead to sometimes of the thymus, a small organ located practical use. Clinicians are trained fatal inflammatory responses. underneath the breastbone. In a to treat the entire organism. Their Alexander Understanding how these cells series of recent studies, we reported perspective is vital in bringing the function — what genes and biological that a distinct DNA element within scattered parts together. 18 19

One of the most striking aspects of stem cells is their flexibility and versatility. They can adapt and respond to both intrinsic signaling and their immediate environment to become a specific type of cell. Glioblastoma multiforme — one of the most common and aggressive types of brain tumor — is recognized for its heterogeneity in appearance and genetics. Scientists have suspected that a small portion of this type of tumor may consist of cancer stem-like cells, which could I was initially drawn to surgery because repopulate the tumor after treatment. This is what drove us to apply it couples intellect with manual elegance. some of my previous stem cell When I was training in the 1990s, research to glioblastoma multiforme it was obvious that opportunities to and discover that a subset of these tumors can generate their own blood improve brain surgery were on the vessels from tumor stem-like cells. horizon — technologies were becoming Instead of simply recruiting blood Viviane Tabar, MD vessels, which many other tumors do, available that would allow us to operate glioblastoma multiforme tumors can NEUROSURGEON more safely and effectively. actually contribute to making their STEM CELL SCIENTIST, own blood vessels. MEMORIAL HOSPITAL I knew this would be a field that The highest-resolution, As a physician-scientist, when I’m would explode in my lifetime, and three-dimensional map is obtained operating on a patient and taking out that has already turned out to be true in the operating room. We a tumor, I am also thinking about in so many ways. stimulate particular areas of the the tumor’s cellular components. To a great extent, brain tumor brain while talking to the patient I think physician-scientists have a surgery has become a form of until we determine — to the exact unique role in that they are so close personalized medicine, as we are now millimeter — where nerve cells that to the subject of study that they are better able to devise strategies for control speech and motion reside. We positioned to ask the right questions removing a particular tumor both are also fortunate to have access to an in the laboratory. before and during the procedure. MRI scanner in the operating room At Memorial Sloan-Kettering, we for both brain and pituitary tumor have the ability to perform complex surgeries, which allows us to see, as surgery with the patient awake the surgery proceeds, how much of and responsive, using advanced the tumor has been removed and how navigation systems. We choose an much remains. awake approach when the tumor is With all of these tools — located in a deep area of the brain managed by our team of surgeons, or near a region involved in speech anesthesiologists, neurophysiologists, expression or speech comprehension. and neurologists — we are able to Before going into the operating design a brain operation in real room, we first perform a traditional time that takes into account the MRI, which I liken to a low- preservation of a patient’s quality resolution Google map. It tells us of life. We are also able to remove what the brain looks like and where tumors that would have been Dr. Tabar consults with Clinical the tumor is located. Then, we previously considered inoperable. Nurse Leader Lystra M. Swift Viviane perform a functional MRI, which Outside of the operating room, in the operating room before a patient surgery. shows where the brain activates when I have been translating my research the patient speaks or moves. involving stem cells to brain tumors. 20 21

My colleagues and I focus primarily on ion channels, proteins that reside within the plasma membrane surrounding cells. The plasma membrane can be likened to a balloon that separates the inside Proteins are amazing machines. Inside of the cell from the outside, and the cells, they act like members of an these channels span the thickness of the balloon. orchestra, carrying out specific functions The plasma membrane is a at specific times and in regulated ways. very thin layer, but it’s incredibly important because it’s what And what we do in my laboratory is try to contains the cell, and cells also understand how proteins work — primarily communicate through it. Membrane by determining what they look like in proteins — proteins such as ion channels that reside within the three dimensions. If you can see something, membrane — are gatekeepers you can get an idea of how it functions. and relay stations that allow each individual cell to communicate Stephen B. Long, PhD with its neighbors and interact with its environment. In comparison STRUCTURAL BIOLOGIST, SLOAN-KETTERING INSTITUTE to proteins found within cells, membrane proteins are typically LOUIS V. GERSTNER, JR. YOUNG INVESTIGATORS more difficult to study and FUND RECIPIENT consequently relatively little is known about their inner workings. Ion channels act like molecular sieves, only letting their particular ion go in or out of a cell. So a calcium channel is selective for calcium, allowing calcium to pass in and out of a cell but not, for example, sodium or potassium. Recently, my lab revealed for the first time the three- dimensional structure of two proteins found in humans, one of which — K2P1 — regulates the flow of potassium ions in and out of cells, and the other — called Orai — which Stephen Dr. Long collaborates with Alexandria M. Miller, a graduate regulates the flow of calcium. In both student in the Gerstner Sloan-Kettering Graduate School of Biomedical Sciences. Ms. Miller is the first author of the cases we used a technique called x-ray potassium ion channel paper Dr. Long discusses in his crystallography, which is a method of narrative. (Miller and Long, Science, January 2012.) determining the shape or structure of 22 23

a protein at an atomic level of detail. of calcium signaling in all sorts In order to do this, we first of biological processes. We still produced large amounts of the have much to learn about calcium proteins, then purified and coaxed signaling, but one setting in which them to form crystals — solid we understand it relatively well is structures in which all the proteins in T cells [a type of immune cell]. are symmetrically lined up. A typical Calcium is an important signaling crystal would contain approximately molecule in these cells, and Orai a trillion protein molecules. Next, is essential for the activation of the we illuminated the crystals with an immune response. As with K2P1, intense beam of x-ray light generated this is very early work, but I hope by a massive instrument called a that what we’ve revealed of the synchrotron located at Brookhaven structure of Orai may set the stage National Laboratories on Long for the development of drugs that Island. As the x-rays interact with target this channel and can be used each individual protein molecule to control the activation of the within the crystal, the rays are immune system in the context of diffracted at different angles. autoimmune diseases, allergy, cancer, Captured on a screen, the diffracted and other disorders. rays form a unique pattern. In a small way, what we do is like From these patterns we were able going to the moon for the first time. to derive detailed information about We were the first people to see what the unique shapes of K2P1 and Orai. K2P1 and Orai look like, and now Finally, using a computer, we built we’re telling others. There are very an atomic model — an architectural few places besides MSKCC where mockup that shows every atom of I could have done what I’ve done both proteins. From this work, we with these projects. The institutional obtained the first visualizations of support of basic science has been any human potassium channel and of crucial, the mindset that says, “We any calcium channel. want you to try difficult things. We By drawing the detailed want you to take risks.” Researchers three-dimensional model of K2P1 here can commit to trying to answer and studying this model atom by basic science questions, limited only atom, we and other scientists will be by their own imaginations. As we able to come up with ideas about how have seen time and again, research this channel works and test our ideas that seeks to address fundamental (Top) The architectural mockup of the calcium channel known as Orai, which in the lab. It’s too early to say with biological questions relating to the regulates the flow of calcium ions into certainty, but I think there are good inner workings of cells can lead, cells and thereby controls crucial cellular functions including immune responses. reasons to be hopeful that our study in the long run, to novel therapies The channel is viewed as it would appear will guide the development of certain for human diseases that wouldn’t from outside the cell. The protein is types of drugs in the future. have been possible without the depicted as a ribbon—a simplification of its thousands of atoms. Glutamate amino Orai has been detected in commitment to basic science acid residues (pictured as yellow and red almost every tissue of the body, research like that ongoing at the sticks) discriminate among ions, allowing which underscores the importance Sloan-Kettering Institute. only calcium ions to pass through. A single calcium ion (magenta sphere) is poised at the entrance to the channel, waiting for the channel to open and allow its entry into the cell. 24 25

respond to drugs, there are genetic factors that influence the way they respond to radiation. So both genetic and tumor-specific factors may contribute to the way a tumor responds to a fixed dose of radiation. Ultimately, we want to understand in real patients, exposed to real doses of radiation, why some respond well and One of the reasons I joined Memorial others poorly. Sloan-Kettering was because of the great A project in my laboratory is aimed at learning more about this opportunities here to do translational and variation in radiation sensitivity. multidisciplinary cancer research. An We’ve taken lymphoid cell lines outstanding example of this is our Imaging from individuals whose entire genomes have been sequenced and and Radiation Sciences program [IMRAS]. we’ve irradiated them. Then we’ve looked at the way the cells handle the radiation. What we see is a spectrum of response that exactly mirrors what we observe in people. Then, because Dr. Powell’s research interests include these genomes are fully known, the role of DNA repair deficiencies in human breast cancer; breast cancer we can do association analyses. genetics and the function of BRCA1 and These are genome-wide association BRCA2 proteins; and the optimization of radiation therapy planning and delivery studies to attempt to relate what it for both early-stage and advanced is about the radiation-sensitive or breast cancer. resistant people that makes them sensitive or resistant. We’re doing The program focuses on looking at of radiation on cells — tools that we these studies in collaboration with how the effects of radiation — in hope to eventually translate into use colleagues in Memorial Hospital’s cells, in mouse models, and in in patients. Clinical Genetics Service and Simon people — can be observed by imaging For example, the presence of the Sloan-Kettering Institute’s and other biological measures. hypoxia [a low concentration of Computational Biology Program Knowing as much as possible about oxygen] in tumors is common, and are looking to discover how a tumor responds to radiation and tumor hypoxia is known to whether there are common parts enables us to more accurately guide compromise the effectiveness of of the genome that associate with treatment decisions and develop radiation and chemotherapy. IMRAS radiation sensitivity or resistance. Simon N. Powell, new treatment strategies. IMRAS members are investigating the Understanding these variations MD, PhD, FRCP reflects collaborative investigations biological underpinnings of tumor will help radiation oncologists across the Department of Radiation hypoxia imaging and are working on make the best treatment decisions CHAIR, DEPARTMENT OF Oncology, the Department of novel imaging methods to measure for each patient. For example, RADIATION ONCOLOGY Medical Physics, the Molecular hypoxia status before, during, and if we know a tumor has built-in JOINT APPOINTMENT, Imaging and Therapy Service, and after treatment. The more precisely radiation resistance mechanisms we MOLECULAR BIOLOGY PROGRAM, SLOAN-KETTERING INSTITUTE the Department of Radiology. we can identify and quantify tumor might choose any one of a number Imaging has made it possible hypoxia, the more we’ll be able to of options — we might not use ENID A. HAUPT CHAIR IN RADIATION ONCOLOGY to evaluate how effective radiation improve patient outcomes. radiation at all, perhaps use a higher therapy is, both during and after Another field of great interest dose, or use a drug to make the treatment. Sophisticated technologies to us is radiation genomics. Broadly tumor more radiosensitive. that already exist give us a lot of speaking, radiation genomics We’re entering a new and information about how a tumor is recognizes that when you irradiate exciting era in radiation oncology, and responding, but IMRAS members people they don’t all respond the these are just several of the many are working to develop even more same way. Just as there are genetic initiatives and research efforts under advanced tools to image the effects factors that control the way people way at MSKCC. 26 27

In 2004, I collaborated on an evidence-based practice project that resulted in the development of a patient-education book for families of MSKCC patients called A Guide for Caregivers. In 2009, I collaborated on another evidence- based practice project within the Department of Radiation Oncology in which we produced guidelines to manage skin reactions in patients receiving radiation. I joined MSKCC in 1991 directly It was through my work with from nursing school, and began my women who received pelvic radiation for rectal and anal cancer that I career caring for neuro-oncology and decided to undertake a research neurosurgery inpatients. The care of these study focused on improving patient patients attracted me because it provided quality of life. I pursued the research under the auspices of the Nursing me with the experience to build a strong Fellowship Program. foundation of nursing skills. But more Radiation to the pelvic area for the treatment of colorectal or importantly, I felt I could offer a great deal gynecologic cancers can create a to patients with neurologic problems. number of side effects in female patients, most notably vaginal Many such patients have motor or stenosis, a narrowing and shortening sensory deficits, and helping them of the vagina. As a result, women Ethel Law, overcome these challenges allowed may experience pain with intercourse RN, ANP-BC, OCN me to begin fulfilling the aspiration and have difficulty tolerating a pelvic that drew me to nursing — to help exam, limiting the effectiveness of NURSE PRACTITIONER, patients have the best quality of life this critical examination. GASTRIC AND MIXED TUMOR SERVICE during and after treatment. To minimize the effects of In 1999, I moved to ambulatory stenosis, women are often advised 2012 SAMUEL AND MAY RUDIN AWARD FOR EXCELLENCE care [treatment delivered to to use a vaginal dilator. Historically, IN NURSING RESEARCH outpatients], working first on the adherence to this therapy is low and

NEW YORK TIMES TRIBUTE TO NURSES Endocrinology Service and later Ms. Law meets with a patient. there has been little follow-up to FINALIST, RESEARCH with the Department of Radiation determine its effectiveness. Oncology, where I again worked with neuro-oncology patients who received radiation as part of their treatment. For the next ten years I cared for gastrointestinal cancer patients receiving radiation therapy. Today, I work in the Gastric and Mixed Tumor Service, a surgical oncology service. Early in my career I knew I wanted to pursue nursing research. I became an active member of MSKCC’s Ambulatory Nursing Research Council and was also the Ethel ambulatory care representative on the institution’s first Evidence-Based Practice Nursing Council. 28 29

My study was focused on evaluating adherence to and the effectiveness of using vaginal dilators to minimize stenosis. We accrued 115 women who had been treated for gynecologic and colorectal cancers at either MSKCC’s main campus or (Clockwise from right) Ms. Law works the regional network sites. This broad closely with Samuel Singer, Chief of sample gave our study a statistically the Gastric and Mixed Tumor Service; Ms. Law in her office; Ms. Law consults relevant representation of the with nurse Ilene Goldman. population. And another wonderful aspect of the study was that it was conducted with a multidisciplinary team approach that included both radiation oncologists and nurses. It was professionally gratifying to bring together this mix of specialists to support the protocol. It made the study even more meaningful, relevant, and thorough. The study opened in 2009 and we are now performing data analyses. I’m hopeful that the study’s work will shed light on the long-term benefits of vaginal dilator use and will lead to the improvement of patients’ quality of life. I am committed to continuing to conduct research as I carry on my clinical work. I love caring for and interacting with patients, which has remained my goal since my first day of nursing. And it’s only from this hands-on experience that I can learn about and understand the clinical needs of patients, which will serve as an inspiration for my next research project.

Ms. Law wishes to thank many people for their support and contributions to her study, including Clinical Nurse Specialist Joanne Frankel Kelvin, radiation oncologist Karen Goodman, Senior Research Specialist Bridget Thom, Senior Research Biostatistician Elyn Riedel, Research Study Assistant Ashlyn Tom, Department of Nursing leadership, the Nursing Fellowship Program, and the Geri and ME Fund for nursing at MSKCC. 30 31

For example, we have discovered that a mutation that affects cells’ epigenetic programs — in this case by changing the structure of chromosomes — occurs in a number of different types of leukemia. Changing that chromosomal Many would argue that the next big structure causes a gene expression program to get turned on when it development in cancer research will be shouldn’t. And for these types of in the field of epigenetics — the study leukemia, we now know exactly what the protein is that allows that of changes in gene expression that are to happen. The protein is called a controlled by factors other than changes histone methyltransferase (HMT), and we’re working to develop in an individual’s DNA sequence. These small-molecule inhibitors of the proteins and mechanisms contribute protein that are now in clinical trials at MSKCC in several adult to cancer development in ways that we leukemias. The research is particularly didn’t really understand ten years ago. exciting because this is the first small-molecule inhibitor of an HMT to be evaluated in humans. It’s becoming increasingly clear that many types of cancer Scott have abnormalities in histone methyltransferases and that these abnormalities are likely part of the tumor development process in many cancers. So what we are learning with Scott A. Armstrong, these new approaches in leukemia is MD, PhD likely to have a much broader impact as we understand more about how PEDIATRIC ONCOLOGIST abnormalities in HMTs are working

VICE CHAIR, BASIC AND to drive cancer development. TRANSLATIONAL RESEARCH, The idea behind MSKCC’s DEPARTMENT OF PEDIATRICS new Leukemia Center [of which MEMBER, HUMAN ONCOLOGY AND Dr. Armstrong is director] is to PATHOGENESIS PROGRAM continue to develop ways to GRAYER FAMILY CHAIR connect what’s going on in the laboratory to what’s going on

Dr. Armstrong specializes in the treatment of children and young adults with leukemia. He is especially interested in developing new therapies that are less toxic and more effective. 32 33

in the clinic. It will provide the of the disease for the better. It’s infrastructure — the people, research, incredibly motivating to think of the and technologies — to help move comfort it gives parents to know that exciting new discoveries from the there are people focused on studying lab into clinical trials as quickly as leukemia as deeply and intensely as possible. We will use next-generation we are, and if our efforts don’t make genomic sequencing technology to a difference for their child, we expect characterize leukemia samples from they will for patients in the future. patients in order to understand, in I don’t know of a better goal than as much depth as possible, which being able to look back in ten or 15 mutations are present in leukemias years and say that I had a tangible and how they work together; develop influence on the way that people are mouse model systems of those treated for cancer. That is definitely leukemias; and then test newly what drives me and the people I work developed therapies to support the with here. rationale for ultimately doing clinical trials in patients. Our goal is to streamline the process and encourage multiple MSKCC labs to work together using a common approach. The synergy that will develop will make it easier for the institution to support these efforts and for pharmaceutical companies and others to work with us. We’ve gotten to the point where basic research discoveries are making a difference for patients. One of the things that makes me most proud as a pediatric oncologist who specializes in treating children with leukemia is when I talk to the parents of a child who has leukemia and I’m able to tell them that we’re making discoveries that are likely to influence the course

(Above) Dr. Armstrong meets with colleagues in his office. (Right) Dr. Armstrong with (from left) research fellows Michael Kuehn, Haihua Chu, and Monica Cusan, and instructor Andrei Kritsov, who are all members of his laboratory. 34 35

In biology, our focus instead is on deriving meaningful insights into biological processes. So while we still like to design clever algorithms to solve problems, the most important thing is asking the right question in the first place. For most of the history of modern biology, scientists have studied one gene at a time. In the late 1990s, it became possible to simultaneously measure the expression of thousands of genes using microarrays [also known as DNA chips], giving a kind of genome-wide “snapshot” of gene Computational biology is a broad field, activity in each sample of cells. but a short explanation for what most More recently, there has been computational biologists do is that we another technological revolution, called next-generation sequencing, use computational methods to help make and now biologists are rapidly sense of very large amounts of biological amassing even more comprehensive data. For example, for each tumor data. I trained as a mathematician, and sample that we study, RNA mathematicians are often attached to sequencing produces millions of finding elegant solutions to problems. short sequences [“reads”] that we Christina Leslie, PhD match to the genome and analyze statistically. [Like DNA, RNA is a COMPUTATIONAL BIOLOGIST, large biological molecule consisting SLOAN-KETTERING INSTITUTE of strings of nucleotides; RNAs are transcribed from the genome using regions of DNA as a template.] This statistical analysis allows us to measure changes in expression for thousands of protein-coding genes as well as RNAs that don’t code for proteins, to detect alterations in the way these genes were processed and to map their mutations. My lab develops computational and statistical methods to exploit this data in order to study how genes are expressed in regular cells and to learn what goes wrong when gene expression gets dysregulated in cancer cells. The methods we use often come from machine learning. These are Postdoctoral fellow Raphael Pellosof (left) and graduate student Julie algorithms that “learn” from data Christina Yang (center) pursue research in Dr. to build a model that can be used Leslie’s laboratory. to make accurate predictions. Many 36 37

PhD student Steve Lianoglou did his PhD degree research in Dr. Leslie’s laboratory.

people have interacted with machine In our work, rather than faces, learning applications, perhaps the data sets are made up of large without realizing it. For example, quantities of data derived from when you use a digital camera to take different kinds of sequencing or a picture, face detection software microarray technologies. Often our locates the faces in the field of view to models are designed to predict how allow the camera to focus better. The genes are regulated. In one project, face detector was “trained” on a big we are trying to train a model data set of photos where the locations that will teach us more about the of faces were known, so that it could mechanism of gene silencing — a learn to discriminate between face process that is dysregulated in many and non-face patches of photos. It diseases, including cancer — using can then be applied to new data — in small pieces of RNA called this case, new faces in the photo you microRNAs. In another project, we want to take — and accurately predict are trying to decode the information the faces. in regulatory regions of the genome that govern differentiation of stem cells into fully specialized cell types. As a computational scientist, I came to Memorial Sloan-Kettering because I wanted to be immersed in an exciting biomedical science environment and work on important problems in cancer biology. This is an amazing place because scientists are encouraged to be ambitious and tackle big questions — which sometimes involves generating huge and complex data sets. Through close collaboration with experimental labs here, we have started to leverage the power of computational and machine learning methods to advance cancer research. 38 39

There are at least 20 types of breast cancer with distinctive features in their morphology [structure and form] that allow them to be identified by microscopy. These tumors collectively are known as special types of breast cancer. Each of them is relatively rare, but together they account for about 25 percent of all breast cancers. The most common type of breast cancer, called invasive ductal carcinoma of no special type, makes Breast cancer is not a single disease, up the other 75 percent of breast but a collection of different diseases that cancers. As the name implies, the category comprises all breast cancers originate in the breast. Pathologists that cannot be classified as of one have described many types of breast of the special types. This group of tumors is diverse, with varying cancer based on careful analysis of tumor morphologic characteristics, clinical samples under the microscope. behaviors, molecular features, and responses to therapies. Although Jorge S. Reis-Filho, special types of breast cancer have MD, PhD been known for a long time, patients Postdoctoral research fellows with the rare types are currently EXPERIMENTAL PATHOLOGIST Luciano Martelotto and treated in the same way as patients Catherine Cowell with Dr. Reis-Filho. AFFILIATE MEMBER, HUMAN with ductal cancers. ONCOLOGY AND PATHOGENESIS Recent large-scale studies PROGRAM investigating the genetic basis of breast cancer have focused on the common type of the disease, and have confirmed that these tumors are diverse in their repertoire of gene mutations. Little is known, however, about the genetic characteristics of rare types of breast cancer. The main goal of my lab is to develop a classification system for all breast cancers that is reflective not only of features seen under the microscope, but also of their molecular characteristics and response to therapies. To achieve this goal, we are studying the special Jorge types of breast cancer that are not categorized as ductal carcinoma. 40 41

In recent years, we and others blood samples with those from the have found that tumors from each tumors themselves. Our aim is to of these rare types are less diverse determine how the information than ductal carcinomas at the obtained from these “liquid molecular level, and that some of biopsies” can be employed to guide these special types of breast cancer treatment decision making for breast are underpinned by very specific cancer patients. genetic changes. I have only been at MSKCC a By using the molecular tools short time, but I already appreciate that we have access to here at what a fantastic institution this MSKCC, we can now determine, at is. The critical mass of basic, an unprecedented level, the genetic translational, and clinical scientists alterations that drive the malignant is unparalleled, and the clinicians behavior of the cells of each special are world-class. There is no other type of breast cancer. Once we know place that brings together people which mutations cause these cells of this caliber who are working on to be malignant or are required for issues that affect cancer patients. I cancer cell survival, we can start have already had the chance to set up figuring out how to develop therapies collaborations with other scientists tailored for patients with these rare and clinicians at MSKCC, and am types of breast cancer. Furthermore, looking forward to developing my when we find the molecular drivers research program with the aim of for these cancers, we will be able matching breast cancer patients to go back and look for the same with the therapy that will be most drivers in ductal carcinoma and beneficial for them. then further classify subsets of these common tumors into groups that have molecular features and behave like the rare types. Our laboratory is also developing approaches to assess the molecular alterations in breast cancer cells by analyzing blood samples from breast cancer patients. We know that cells and genetic material from breast cancers can be found in the blood. We are currently applying cutting-edge genetic tools to compare cancerous materials obtained from

(Opposite page) Visiting clinical fellow Francois-Clement Bidard (left) and bioinformatics postdoctoral research fellow Charlotte Ng with Dr. Reis-Filho in his laboratory. 42 43

Statistical Profile

PATIENT CARE 2008 2009 2010 2011 2012 STAFF 2008 2009 2010 2011 2012

Patient Admissions: Adults 21,039 21,932 22,852 22,983 23,139 Sloan-Kettering Institute Members 133 140 142 143 149 Patient Admissions: Children 1,650 1,537 1,494 1,503 1,459 Hospital Attending Staff 727 768 804 834 876 Total Admissions 22,689 23,469 24,346 24,486 24,598 Registered Nurses 1,734 1,845 1,945 2,018 2,133 Support Staff 7,945 8,321 8,613 8,989 9,244 Total Patient Days 139,847 140,224 143,532 140,990 149,368 Average Patient Stay (days) 6.2 6.0 5.9 5.8 6.1 Total Staff* 10,505 11,039 11,469 11,950 12,402 Bed Occupancy Rate Volunteers 871 917 942 1,058 1,018 (based on adjusted bed count) 88.0% 88.5% 83.7% 82.2% 87.0% *In 2012, 34 staff members held appointments in both the Institute and the Hospital. Outpatient MD Visits: Manhattan 384,889 406,024 418,415 432,802 436,510 Outpatient MD Visits: Regional Network 81,995 94,293 97,658 103,098 104,964 EDUCATION 2008 2009 2010 2011 2012 Total Outpatient Visits 466,884 500,317 516,073 535,900 541,474

Screening Visits 28,888 27,369 23,373 20,518 15,519 Residents and Clinical Fellows — Positions 418 436 447 440 445 Surgical Cases 18,035 19,233 19,362 19,374 19,691 Residents and Clinical Fellows — Annual Total 1,609 1,651 1,625 1,676 1,682 Research Fellows 254 303 295 321 320 Radiation Treatments and Implants: Manhattan 58,494 57,856 59,223 60,393 60,289 Research Scholars 140 121 132 131 124 Radiation Treatments and Implants: Network 43,550 47,987 47,926 51,615 50,476 Research Associates 87 90 94 82 89 Total Radiation Treatments and Implants 102,044 105,843 107,149 112,008 110,765 Graduate Research Assistants — — 23 29 39 PhD Candidates 232 227 231 225 222 X-ray Examinations and Special Procedures 346,157 358,052 362,609 377,360 391,187 MD/PhD Candidates 29 28 26 21 21 Clinical Investigation Protocols (open to accrual) 522 507 552 552 657 Registrants in CME Programs 2,115 2,395 2,554 2,533 3,968 Medical Observers 561 572 541 526 566 Medical Students 358 399 391 429 431 Nursing Students 72 109 105 142 178 Social Work Students 6 6 6 6 6 Radiation Oncology Technology Students 15 15 14 14 13 Cytotechnology Students 3 3 2 3 4 Physical Therapy Students 3 3 3 4 7 Occupational Therapy Students 5 4 3 3 4 44 45

OPERATING REVENUES (in thousands) 2008 2009 2010 2011 2012

Patient Care Revenue $1,606,989 1,723,313 1,854,776 2,141,421 2,201,941 Grants and Contracts 163,352 167,495 186,327 190,948 185,160 (in thousands) Financial Summary Contributions Allocated to Operations 108,844 126,250 117,323 130,791 144,497 Royalty Income 94,131 62,232 68,663 77,510 78,350 Other Income 41,963 43,144 44,874 48,351 51,167 Investment Return Allocated to Operations 116,546 103,998 100,389 104,699 75,877 Transfer of Board-Designated Annual Royalty Annuitization 33,122 37,158 41,578 46,417 51,709 $2,788,701 $2,697,371 2012 Total Total Operating Revenues $2,164,947 2,263,590 2,413,930 2,740,137 2,788,701 Operating Revenue 2012 Total Operating Expenses

OPERATING EXPENSES (in thousands) 2008 2009 2010 2011 2012

Compensation and Fringe Benefits $1,164,155 1,286,536 1,361,032 1,466,667 1,582,212 $2,201,941 $1,582,212 Patient Care Revenue Compensation and Purchased Supplies and Services 684,872 757,863 772,968 835,621 879,219 Fringe Benefits Provision for Bad Debts and Assessments 6,823 10,881 11,046 18,285 17,541 Depreciation and Amortization 175,870 171,806 175,494 195,461 210,810 Interest Expense 59,023 64,997 47,931 57,098 54,894 Less Fund-Raising Expenses Transferred to Non-Operating Income (Expenses) (36,048) (40,320) (43,926) (44,665) (47,305)

$185,160 Grants and Contracts Total Operating Expenses $2,054,695 2,251,763 2,324,545 2,528,467 2,697,371

$144,497 Income from Operations $110,252 11,827 89,385 211,670 91,330 Contributions Allocated $879,219 to Operations Purchased Supplies and Services PHILANTHROPY (in thousands) 2008 2009 2010 2011 2012 $78,350 Royalty Income $210,810 Depreciation and Philanthropy $279,103 166,247 237,666 301,374 231,159 $75,877 Amortization Investment Return Allocated to Operations $54,894 CAPITAL SPENDING (in thousands) 2008 2009 2010 2011 2012 Interest Expense $51,709 $17,541 Transfer of Board-Designated Capital Spending $345,135 226,049 262,371 223,251 258,613 Annual Royalty Annuitization Provision for Bad Debts and Assessments

$51,167 BALANCE SHEET SUMMARY (in thousands) 2008 2009 2010 2011 2012 ($47,305) Other Income Less Fund-Raising Expenses Transferred to Assets $5,578,522 6,068,707 6,448,415 6,790,005 7,795,608 Non-Operating Income (Expenses) Liabilities 2,354,618 2,467,135 2,550,889 2,848,843 3,562,566

Net Assets $3,223,904 3,601,572 3,897,526 3,941,162 4,233,052 46 47

BOARDS OF OVERSEERS AND MANAGERS as of December 31, 2012 PRINCIPAL LEADERSHIP MEMORIAL SLOAN-KETTERING CANCER CENTER as of December 31, 2012

Douglas A. Warner III James D. Robinson III Craig B. Thompson, MD John R. Gunn Chairman Honorary Chairman President and Chief Executive Officer, Executive Vice President Memorial Sloan-Kettering Cancer Center Richard I. Beattie Marie-Josée Kravis Louis V. Gerstner, Jr. Vice Chair of Boards Vice Chair of Boards Vice Chair of Boards Chair, Board of Managers, Chair, Board of Managers, Memorial Hospital Sloan-Kettering Institute Robert E. Wittes, MD Thomas J. Kelly, MD, PhD Physician-in-Chief, Director, Sloan-Kettering Institute Clifton S. Robbins Norman C. Selby Craig B. Thompson, MD Memorial Hospital Treasurer Secretary President and Chief Executive Officer

Larry Norton, MD Maureen Killackey, MD Frederick R. Adler Bette-Ann Gwathmey Benjamin M. Rosen Deputy Physician-in-Chief, Deputy Physician-in-Chief Richard I. Beattie William B. Harrison, Jr. David M. Rubenstein Breast Cancer Programs, and Medical Director, Mrs. Edwin M. Burke Jane D. Hartley Jack Rudin Memorial Hospital MSKCC Regional Care Network Mrs. John J. Byrne Benjamin W. Heineman, Jr. Lewis A. Sanders Mrs. Joseph A. Califano, Jr. Mrs. Ann Dibble Jordan Fayez S. Sarofim Ian M. Cook David H. Koch Norman C. Selby Stanley F. Druckenmiller Marie-Josée Kravis Stephen C. Sherrill Anthony B. Evnin Mrs. John L. Marion Peter J. Solomon Kerry Bessey Jason Klein Roger N. Parker, JD Roger W. Ferguson, Jr. Paul A. Marks, MD William C. Steere, Jr. Vice President, Human Resources Vice President and Senior Vice President and Steve Forbes Donald B. Marron Scott M. Stuart Chief Investment Officer General Counsel William E. Ford Jamie C. Nicholls Craig B. Thompson, MD Murray F. Brennan, MD Richard N. Foster James G. Niven Lucy R. Waletzky, MD Vice President for International Kathy Lewis Patricia C. Skarulis Stephen Friedman Hutham S. Olayan Douglas A. Warner III Programs and Director, Vice President, Public Affairs Vice President, Information Systems Ellen V. Futter E. Stanley O’Neal Peter Weinberg Bobst International Center and Chief Information Officer Philip H. Geier, Jr. Bruce C. Ratner Jon Winkelried Edward J. Mahoney Louis V. Gerstner, Jr. Annette U. Rickel, PhD Deborah C.Wright Eric Cottington, PhD Vice President, Facilities Management Ellen Miller Sonet Laurie H. Glimcher, MD Clifton S. Robbins Jeff Zucker Vice President, Research and Vice President, Marketing Jonathan N. Grayer James D. Robinson III Mortimer B. Zuckerman Technology Management Kathryn Martin John R. Gunn Virginia M. Rometty Senior Vice President Carolyn B. Levine, JD Michael P. Gutnick and Hospital Administrator Associate General Counsel and Senior Vice President, Finance, Corporate Secretary Board of Overseers Emeriti and Assistant Treasurer Richard K. Naum Mrs. Elmer H. Bobst James W. Kinnear Mrs. Arnold Schwartz Vice President, Development Peter O. Crisp Elizabeth J. McCormack, PhD J. McLain Stewart Richard M. Furlaud

Paul A. Marks, MD Harold Varmus, MD Board of Scientific Consultants President Emeritus President Emeritus Frederick R. Appelbaum, MD Levi A. Garraway, MD, PhD Stanley R. Riddell, MD Richard Axel, MD Joseph L. Goldstein, MD William R. Sellers, MD For a listing of the members of the professional staff of Memorial Hospital and the Sloan-Kettering Institute, Philip A. Cole, MD, PhD Gregory Hannon, PhD Gregory L. Verdine, PhD please visit www.mskcc.org/annualreport. Nancy E. Davidson, MD Caryn Lerman, PhD Ralph Weissleder, MD, PhD Titia de Lange, PhD Arthur Levinson, PhD Irving L. Weissman, MD James R. Downing, MD Sir Paul Nurse, FRS 48 49

LOUIS V. GERSTNER, JR. GRADUATE SCHOOL OF BIOMEDICAL SCIENCES The Campaign for MEMORIAL SLOAN-KETTERING CANCER CENTER as of December 31, 2012 Memorial Sloan-Kettering Louis V. Gerstner, Jr. Craig B. Thompson, MD Chairman of the Board President

Thomas J. Kelly, MD, PhD Kenneth J. Marians, PhD Linda D. Burnley Provost Dean Associate Dean The Campaign for Memorial Sloan-Kettering John R. Gunn Michael P. Gutnick Carolyn B. Levine, JD maintained strong momentum in 2012, with Treasurer Assistant Treasurer Secretary gifts and pledges as of December 31 totaling more than $2.752 billion. Generous supporters Trustees Richard I. Beattie Jonathan N. Grayer Benjamin M. Rosen from around the world contributed cash gifts Richard N. Foster David H. Koch Norman C. Selby totaling $235.6 million over the course of the Stephen Friedman Marie-Josée Kravis Craig B. Thompson, MD Ellen V. Futter Hutham S. Olayan Douglas A. Warner III year, including a record-setting $61.3 million in Louis V. Gerstner, Jr. December. This marks the largest December total in Center history, and the 130,000 gifts processed during the month helped bring 2012

SLOAN-KETTERING DIVISION to an especially strong close. WEILL CORNELL GRADUATE SCHOOL OF MEDICAL SCIENCES as of December 31, 2012

Thomas J. Kelly, MD, PhD Kenneth J. Marians, PhD Director Director, Graduate Studies

As the Campaign continues ahead of pace • David M. Rubenstein committed Graduate Program Co-Chairs toward its $3.5 billion goal under the $10 million to establish the David M. leadership of co-chairs Douglas A. Warner III Rubenstein Center for Pancreatic Cancer (From top) Nikola P. Pavletich, PhD Alan Hall, PhD Alexander Y. Rudensky, PhD Douglas A. Warner III, and Louis V. Gerstner, Jr., and President Research, which enables the launch of an Louis V. Gerstner, Jr., Biochemistry and Cell and Developmental Immunology and Microbial Craig B. Thompson, its ongoing achievement intensive, fully integrated effort designed to Craig B. Thompson. Structural Biology Unit Biology Unit Pathogenesis Unit is sustained by the generosity of donors at achieve meaningful progress against one of Stewart Shuman, MD, PhD David A. Scheinberg, MD every level. Benefactors of Memorial Sloan- the deadliest forms of cancer. Molecular Biology Unit Pharmacology Unit Kettering generated a 30 percent increase in new pledges in 2012 from the previous year, • The Tow Foundation pledged $8 million and the commitment and support for the to underwrite the work of the Michael G. Center’s lifesaving mission demonstrated by Harris Cell Therapy & Cell Engineering its donors is exemplified by the following: Facility (formerly the Center for Cell Engineering), which develops advanced cell-based cancer therapies through cutting-edge molecular and cellular techniques. This brings the Tow Foundation’s total giving to the Campaign to more than $38 million. 50 51

Donors to the Campaign for (Clockwise, from top) The Washington, DC, Cycle for Survival event at Equinox Bethesda on February 10; Fred’s Team members (from left) Emily Fried, Nicole Gill, Memorial Sloan-Kettering Brynna Lipson, and Jennifer Cunningham at the finish of the Brooklyn Half Marathon; Mark Rubin, the 2012 RBC Decathlon’s top athlete, flanked by event co-founders Dave Maloney (left) and Marc Hodulich.

• The Estate of Samuel Mitchell, a $100,000,000 OR MORE Laurance S. Rockefeller Allan H. Selig long-standing donor to Memorial The Estate of Geoffrey Beene Laurance S. Rockefeller Fund The Peter Jay Sharp Foundation Sloan-Kettering, made a bequest of The Starr Foundation Donna and Benjamin Rosen Mr. and Mrs. Richard Siegal Mortimer B. Zuckerman David M. Rubenstein The Society of MSKCC Thrift Shop $3.6 million in unrestricted funds to the Robert F. X. Sillerman and Laura Baudo Estate of Margaret McCormack Sokol Center, part of the more than $37 million $50,000,000 — $99,999,999 Sillerman through their Tomorrow Stand Up To Cancer in bequests received by the Center in 2012. Mr. and Mrs. William H. Goodwin, Jr., Foundation Swim Across America, Inc. and the Commonwealth Foundation The Simons Foundation The William and Lynda Steere • The Thompson Family Foundation for Cancer Research The Society of MSKCC Special Foundation made a $3.8 million grant in David H. Koch Projects Committee UBS support of prostate cancer research at The Leonard and Evelyn Lauder Stop & Shop Supermarket Company, Sue and Edgar Wachenheim III Foundation Inc. Michael A. and Zena Wiener Memorial Sloan-Kettering as part of a Virginia and D. K. Ludwig Fund for Mr. and Mrs. Douglas A. Warner III groundbreaking international Cancer Research $2,500,000 — $4,999,999 collaboration with Israel’s Weizmann Robertson Foundation $5,000,000 — $9,999,999 Anonymous Institute of Science. Anonymous Mr. and Mrs. Bruce Adam $25,000,000 — $49,999,999 Bristol-Myers Squibb Company The Allbritton Foundation The Atlantic Philanthropies The Carson Family Charitable Trust Bethany Allen The driving commitment to making Mr. and Mrs. Jack Byrne The Steven A. and Alexandra M. Cohen Estate of Eleanor Backer a difference is also displayed by the Stanley F. and Fiona Druckenmiller Foundation, Inc. Band of Parents Foundation thousands of volunteers and participants in The Louis V. Gerstner, Jr. Trust of Richard J. Eisemann The Arthur & Rochelle Belfer athletic fundraisers who support Memorial Foundation, Inc. Charlotte and Bill Ford III Foundation Sloan-Kettering’s work with their efforts each The Sidney Kimmel Foundation Mr. and Mrs. Frederic B. Garonzik Estate of Lillian R. Berkman year. The newest of these fundraisers, The The Tow Foundation Mr. and Mrs. Philip H. Geier, Jr. The James E. and Diane W. Burke Estate of Sherlock Hibbs Foundation, Inc. RBC Decathlon, challenges professionals $20,000,000 — $24,999,999 ICAP Estate of Nizza Burstyn in financial services to compete against one Anonymous The Robert J. Kleberg, Jr., and Mrs. D. Wayne Calloway another in ten separate athletic events. In Prostate Cancer Foundation Helen C. Kleberg Foundation Iris and B. Gerald Cantor Foundation 2012, participants in The RBC Decathlon And despite the cancellation of the The Society of MSKCC Trust of L. H. P. Klotz The Kristen Ann Carr Fund raised nearly $1.3 million for pediatric cancer 2012 ING New York City Marathon in the John W. Kluge James D. Carter research at the Center, more than double the aftermath of Hurricane Sandy, members $10,000,000 — $19,999,999 Trust of Evelyn Lauder Estate of Franklin Chenenky Anonymous The Lebensfeld Foundation Pei-Yuan Chia and the Chia Family amount raised in the previous year. of Fred’s Team registered to participate on Trust of Burton Abrams Estate of Tse Kyung Lee Foundation The Center’s Cycle for Survival behalf of Memorial Sloan-Kettering showed The Elmer and Mamdouha Bobst The Leon Lowenstein Foundation, Inc., The Irma L. and Abram S. Croll indoor team cycling event is one of the extraordinary commitment, raising a total for Foundation and Robert and John Bendheim Charitable Trust fastest-growing athletic fundraisers in the the year of more than $4.6 million to support The Breast Cancer Research Martin S. and Sheila Major and Family The Doris Duke Charitable Foundation country. The most recent event saw 12,000 high-priority research at the Center. Foundation Melanoma Research Alliance The Mitzi and Warren Eisenberg Mr. and Mrs. Raymond T. Dalio Estate of Samuel U. Mitchell Foundation/The Susan and participants across ten cities nationwide join Memorial Sloan-Kettering benefits The Stephen and Barbara Friedman Jamie Nicholls and Fran Biondi Leonard Feinstein Foundation the battle, raising more than $14 million for enormously from the generosity of its Foundation Charitable Trust Estate of Elizabeth M. Frelinghuysen research into rare cancers. In its seven-year committed benefactors, whose support at Alan and Sandra Gerry The Robert and Kate Niehaus Estate of Jeanette R. Fulham history, Cycle for Survival has raised a total of every level helps the Center’s physicians and The Arnold and Arlene Goldstein Foundation Estate of Francis Gonzalez $31.5 million, funding 53 clinical trials and scientists pursue the most-promising avenues Family Foundation Peserga International Foundation Mr. and Mrs. Jonathan N. Grayer studies in its first six years alone. of research and advance the standard of care The Donald B. and Catherine C. Marron Mr. and Mrs. John S. Reed Lita Annenberg Hazen Charitable Trust Foundation Dorothy Rose and Dr. Milton Rose William Randolph Hearst Foundations for the benefit of patients around the world. Mr. and Mrs. Milton Petrie Estate of Joseph J. Santry Estate of Irma A. Howard 52 53

DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING

W. M. Keck Foundation The Andrea and Charles Bronfman Golfers Against Cancer Foundation Morgan Stanley The Sussman Family Fund The Cancer Research Foundation of Estate of Martin C. Kessler Philanthropies, Inc. The Gordon Fund The William T. Morris Foundation Trust of M. Allen Swift America F. M. Kirby Foundation, Inc. Estate of Helen Brown Trust of Jane H. Gordon Mushett Family Foundation, Inc. Tarnopol Family Foundation The Richard E. Capri Foundation on Susan G. Komen for the Cure Trust of Emil A. Buelens Grass Family Foundation Trust of Saul Nathonsohn Estate of Lillian Tomek behalf of the Wolf Family Henry and Marie-Josée Kravis Estate of Diane B. Burkhart The Marion and Louis Grossman Nonna’s Garden Foundation The Beth C. Tortolani Foundation Estate of Richard B. Carman Myra Nelson Larrison The Burnett Foundation Foundation The Olayan Group Anthony and Carole Trapani The Tina and Richard V. Carolan LIVESTRONG Foundation Cancer Research Institute Mr. and Mrs. Robert Grossman Pediatric Cancer Foundation The Trump Group Foundation The Lymphoma Foundation Estate of Marion B. Carstairs Trust of Helen Guerin Estate of Frederick Pelda Mr. and Mrs. Thomas Tuttle James & Patricia Cayne Trust of Philip R. Mallory Robert B. Catell Hackers for Hope John and Francie Pepper Universal Network Television Charitable Trust Trust of Estelle A. Manning John and Michael Chandris Mr. and Mrs. James J. Hagan Trust of Elizabeth L. Perkins The V Foundation for Cancer Research The Y. C. Ho/Helen and Michael Chiang The T. J. Martell Foundation for Trust of Charles P. Ciaffone Mr. and Mrs. John J. Hannan Perry Capital LLC John L. Vogelstein Foundation Leukemia, Cancer and AIDS Trust of George Clegg Estate of Margaret H. Hanson Estate of Jeanne Poli Trust of Edward W. Vollintine Trust of Betty R. Ciaffone Research The Comer Science and Education Stephen P. Hanson Laura and Christopher A. Pucillo Lucy R. Waletzky, MD Citigroup Estate of Charles J. Mauro Foundation Jamie and Jeffrey Harris Sara and Iser Rabinovitz Joan and Sanford I. Weill The Simon & Eve Colin Foundation The Abby R. Mauzé Charitable Trust The Connecticut Sports Foundation The Heckscher Foundation for Children Mrs. Katharine J. Rayner Louis and Jane Weinstock Estate of Harry J. Colish Florence Miner Trust of James J. Corbalis, Jr. Mr. and Mrs. Benjamin W. Heineman, Jr. Charles H. Revson Foundation The Lillian S. Wells Foundation, Inc. Constant Convocation Center Gloria Miner Countess Moira Foundation Marie B. Hilliard Estate of Edith Roberts Mr. and Mrs. Clay T. Whitehead Cookies for Kids’ Cancer The Naddisy Foundation Mr. and Mrs. Peter O. Crisp The Charles and Marjorie Holloway Estate of Josephine T. Robertson Estate of Carolyn H. Wilson The Elaine Terner Cooper Foundation The New York Community Trust Cure Breast Cancer Foundation, Inc. Foundation, Inc. Estate of Anne Morales Rodgers Winterburn Foundation Trust of Faye Copeland The Samuel I. Newhouse Foundation Estate of Helen M. Curry Estate of Harriet Huber The Felix and Elizabeth Rohatyn Diana S. Wister Estate of Leonard Corso Stavros S. Niarchos Foundation Trust of Margaret E. Dahm Estate of Doris Hutchison Foundation The Wolfensohn Family Foundation Sharon Levine Corzine Ronald O. Perelman Dennis D. Dammerman IBM Corporation The Laura Rosenberg Foundation, Inc. Mr. and Mrs. Robert Wright Chandler Cox Foundation Estate of Catherine R. Price Estate of Charles E. Dillman Trust of Harry C. Jaecker, Jr. Estate of Lillian E. Rosenmerkel Zev’s Fund Inc. Estate of Helen M. Cramer Frederick Henry Prince Memorial Fund Gloria DiPietro-Cooper The Jewish Communal Fund Juliet Rosenthal Foundation, Inc. Ziff Brothers Investment, LLC The Dana Foundation Bruce C. Ratner The Ellison Medical Foundation Estate of Clarence W. Johnson Jack Rudin Mr. and Mrs. Marvin H. Davidson The Robbins Family Foundation Entertainment Industry Foundation Estate of Wilda Johnson The Louis & Rachel Rudin Foundation $500,000 — $999,999 Davis Charitable Foundation The Jim and Linda Robinson Foundation Estate of Selma Ettenberg Trust of Marion Kahn The May & Samuel Rudin Family Estate of Marguerite Abrams Trust of Myra Davis Estate of Marilyn L. Schaefer The Eunice Foundation Estate of Mary B. Ketcham Foundation Alex’s Lemonade Stand Estate of Sandra Newman Dawson Estate of Grace A. Shapro Anthony B. Evnin Estate of John W. Knox The Peter M. Sacerdote Foundation Allen & Company, Inc. The Thompson Dean Family The Joachim Silbermann Family Estate of Harry Fagen Mr. and Mrs. Matania Kochavi Lewis A. Sanders The Rita Allen Foundation Foundation Paul E. Singer Farmer Family Foundation Estate of Rosemarie Krulish Fayez Sarofim & Co. American Brain Tumor Foundation The DeGroot Family Foundation Joan and Joel Smilow Trust of Harold Farrington The Thomas G. Labrecque Foundation Estate of Margaret W. Schafer American Skin Association Annette and Oscar de la Renta George Strawbridge, Jr. The John K. Figge Family Trust of Grace Fay Lamb Estate of Catherine M. Schooley Anonymous Deutsche Bank Securities Inc. The Joseph and Arlene Taub Estate of Barbara D. Finberg Philippe Laub Mr. and Mrs. Norman C. Selby Roland Arthur Trust of James Douglas Foundation The Jerome and Anne C. Fisher Estate of Wilhelmina LeJeune Dr. David E. and Beth Kobliner Shaw Aventis Pharmaceuticals, Inc. Estate of Louis Duenweg Margaretta J. Taylor Charitable Foundation Estate of Harold F. Levinson Trust of Henry H. Shepard Mr. and Mrs. Robert C. Baker The Emerald Foundation The Thompson Family Foundation Flight Attendant Medical Research Estate of Ada Leventhal Mr. and Mrs. H. Virgil Sherrill Family Foundation Mr. and Mrs. David Epstein Estate of Richmond E. Thompson Institute Leon Levy Foundation Mr. and Mrs. Stephen C. Sherrill Estate of Eileen W. Bamberger Arthur Falcone Trust of Jane Toplitt The Stephanie and Lawrence Flinn, Jr. The LisaBeth Foundation Alfred J. and Stephanie Shuman Trust of Barbara G. Bargar Estate of Katie Fasal TOSA Foundation Charitable Trust The Litwin Foundation through the Windmill Lane Estate of Doris A. Baumann Estate of Beatrice Feinstein Estate of Harry N. Forman Robert S. Ludwig and Foundation Richard I. Beattie The Fibrolamellar Cancer Foundation $1,000,000 — $2,499,999 Lorraine Friedman Gwenyth E. Rankin Mr. and Mrs. Herbert J. Siegel The Arnold and Mabel Beckman Estate of Alice H. Ficht Anonymous Friezo Family Foundation The Lustgarten Foundation for M. Steven and S. David Silbermann Foundation Trust of Alice D. Fiedler Mr. and Mrs. Andrew B. Abramson Fund for Ophthalmic Knowledge Pancreatic Research The Rosanne H. Silbermann Trust of William T. Benitt Trust of Marie Finch Mr. and Mrs. Frederick R. Adler Estate of Frank H. Gabriel Lymphoma Research Foundation Foundation The Besen Family The Michael J. Fox Foundation Mr. and Mrs. Fred M. Alger III Gabrielle’s Angel Foundation Mr. and Mrs. J. Randall MacDonald Mary Ann and Arthur M. Siskind Jane and Bill Bird Trust of Ira S. French Alliance for Cancer Gene Therapy Sara Gadd Mr. and Mrs. Joel Mallah through the Siskind Family Trust of Susan E. Black Trust of Dr. Benjamin T. Friedman Stephen and Madeline Anbinder Estate of Thomas Gardiner The Maloris Foundation Sarcoma Fund Betty, James, and Thomas Blake (The Trust of Oscar H. Friedman John M. Angelo and Judy Hart Angelo Trust of Virginia L. Garrison Margaux’s Miracle Foundation The Skirball Foundation Thomas Blake, Sr. Memorial Fund) Estate of Joseph G. Gaumont Estate of Roone P. Arledge Trust of Florence K. Geffen Mrs. Joseph L. Martino Trust of William Kirkland Smith The Blue Dot Foundation Joe Gellert The Award of Courage Corporation The Lawrence M. Gelb Foundation, Inc. The G. Harold & Leila Mathers Trust of Emily V. Smyth Trust of Ethelvida Boehme Estate of Lillian B. George The Batishwa Fellowship Richard L. Gelb Foundation Trust of Clemance and Edwin Snyder Estate of William Boehme The Gerber Foundation Trust of Edgar D. Baumgartner Genentech Mrs. William L. Matheson Ira Sohn Conference Foundation, Inc. Mr. and Mrs. David Boies The Aaron and Betty Gilman Family Estate of Mary Ann Benjamin General Electric Company Merrill Lynch & Co. Peter J. Solomon Family Foundation Trust of Frederick W. Bonacker, Jr. Foundation Mr. and Mrs. Daniel C. Benton Eileen Genet Fund for Ovarian Cancer Foundation, Inc. The Sontag Foundation Estate of Adele Bozio Estate of Thelma Gish Dan Biele Research and Prevention Fred and Marie-Noelle Meyer Sportsmen for Charity Trust of Nancy J. Bradford Estate of William J. Glasgow Allen and Joan Bildner Trust of Josephine A. Gilmore Estate of Wilma S. Mills St. Baldrick’s Foundation Mr. and Mrs. Peter Bren Estate of Robert E. Gleason The Anita and Leonard Boxer Family GIST Cancer Research Fund Estate of Robert C. Mitchell Estate of Stanley R. Stones Terri Brodeur Breast Cancer Mr. and Mrs. Robert S. Goldberg Foundation Estate of Anna H. Gleason Trust of Douglas C. Mohl Mr. and Mrs. David K. Storrs Foundation The Joyce & Irving Goldman Family Breast Cancer Alliance, Inc. Miriam and Alan Goldberg The Ambrose Monell Foundation The Margaret Dorrance Strawbridge Trust of Dorothy Fielder Brown Foundation Mr. and Mrs. Viatcheslav I. Brecht Goldman Sachs & Company Estate of Warren A. Montel Foundation of PA Mrs. Edwin M. Burke The Horace W. Goldsmith Foundation 54 55

DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING

Estate of Helen M. Golen National Childhood Cancer Foundation Tudor Investment Corporation Albert and Betty Bodian Trust of June K. Evans Trust of Abraham Hases Peter M. Guggenheimer News Corporation Daniel P. and Grace I. Tully Foundation The Bondi Foundation Trust of Lillian Evans Estate of Irma Hayes The Marc Haas Foundation The New York Yankees Foundation Turner Construction Company Trust of Lillian Borchardt Lord Evans of Watford Hecht & Company Philanthropic Mr. and Mrs. William W. Haerther, Jr. Occidental Petroleum Corporation United Way of Tri-State The Louis L. Borick Foundation Trust of Sarah W. Ewing Foundation Estate of Ethel V. Haldeman Trust of Melba M. O’Connell Uniting Against Lung Cancer The Albert C. Bostwick Foundation Mr. and Mrs. Barton Faber Mr. and Mrs. Charles Heimbold, Jr. Evelyn A. J. Hall Charitable Trust The Sylvan and Ann Oestreicher Trust of Ward M. Vanderpool Mr. and Mrs. Kevin A. Bousquette Estate of Giuliana Fantini Cherie Henderson and David Poppe Mr. and Mrs. Stephen L. Hammerman Foundation Vanguard Charitable Endowment Fund Trust of Alice M. Branch Trust of Mary E. Farrell Heyman-Merrin Family Foundation Mr. and Mrs. William B. Harrison, Jr. Trust of Jo Anne H. Olmsted Variety – The Children’s Charity The Braver Foundation Estate of Ralph R. Feigelson Brian J. Higgins Estate of Judith B. Helfant E. Stanley O’Neal Richard C. Vergobbi Estate of Paul P. Brieloff The Feinstein Family Foundation The Catie Hoch Foundation Estate of Ruth H. Hewlett Estate of Beatrice P. K. Palestin Estate of Christine Villano Estate of Madalyn B. Bryant Paul Felzen Estate of Laverne Hodges Marie B. Hilliard Elsa U. Pardee Foundation Estate of Ingeborg K. Watson The Bugas Fund Hilary Carla Feshbach Estate of Martha Holloway Trust of Benjamin Holmes The Perelman Family Foundation Trust of Thomas J. Watson, Jr. Hilary and Joseph A. Califano, Jr. Mrs. Frederick Fialkow Mr. and Mrs. D. Gregory Horrigan Trust of Karla Homburger The Perkin Fund Estate of Ruth C. Weismann Cancer Support Services, Inc. Estate of Selma Fine Estate of Chester S. Howard William Lawrence & Blanche Hughes Pfizer Inc. Mr. and Mrs. Harold S. Wertheimer The Paul Robert Carey Foundation The Grace J. Fippinger Estate of Karen L. Hudson Foundation Estate of Lucie Picard Trust of Reamer W. Wigle Mr. and Mrs. Kenneth Carmel Foundation, Inc. The Howard Hughes Medical Institute The Patricia M. Hynes and Estate of Marion M. Pincus The Meryl and Charles Witmer Mr. and Mrs. Michael Carr First Quality Enterprises, Inc. Edith M. Hunter Roy L. Reardon Foundation Mr. Bernard Posner Charitable Foundation Estate of Georgia M. Catrini Estate of Susan L. Fischer IBM International Foundation Deanne and Arthur Indursky Margot Rosenberg Pulitzer Foundation Trust of Richard A. Yudkin Trust of Ruth C. Celarek Jeanne Donovan Fisher Bruce H. Jacobs Invest for Children, a Foundation of The Mitchell P. Rales Family Estate of Anna M. Zavatt Estate of Burdette G. Chamberlin The Jodi Spiegel Fisher Cancer Trust of Clyde H. Jacobs Investindustrial Foundation Ronald Zung Joan Chorney Foundation Janssen Pharmaceutica Products LP Mrs. H. Anthony Ittelson John Bradbury Reed CIBC World Markets Corporation Aaron I. Fleischman Foundation Estate of Mira Jelin The Rona Jaffe Foundation Trust of Irene Dorothy Reel $250,000 — $499,999 The Clark Foundation The Floren Family Foundation The Robert Wood Johnson Foundation Johnson & Johnson Estate of Agnes Rezler Trust of George Aaron Estate of Dorothy L. Cobb Fondazione Italiana Estate of Al Jolson Estate of Horace A. Jones Estate of Richard A. Riecker Accelerate Brain Cancer Cure (ABC2) Trust of Joan F. Cobb For the Love of Life Estate of Robert L. Jones Fritz and Adelaide Kauffmann Drs. Helena and David Rodbard Foundation Frances B. Cohen Trust of William Forbes Max Kade Foundation, Inc. Foundation Alexander J. Roepers Estate of John D. Adams, Jr. Mr. and Mrs. John K. Colgate, Jr. Foundation 14 Mr. and Mrs. Robert B. Kay Kinetics Foundation Shafi Roepers The Louis & Bessie Adler Foundation The Julien Collot Foundation, Inc. The Terry Fox Run for Cancer Research Estate of Helen Keena Estate of Joan E. Kinley Trust of William C. Rogers The Alliance Against ASPS Foundation The Community Foundation for The Evan Frankel Foundation Trust of Fenton O. Keister Estate of Hazel V. Knapp Mr. and Mrs. Stephen J. Rosenthal Trust of Eileen Alpert Northern Virginia – Hanlon Mr. and Mrs. Lewis Frankfort Robert J. Keller Estate of Ruth Koch The Arthur Ross Foundation, Inc. Alzheimer’s Association Family Fund The Edna R. Fredel Charitable Lead Mr. and Mrs. John R. Kennedy The Koodish Family Charitable Trust Damon Runyon Cancer Research American Health Assistance Estate of Robert I. Conley Annuity Trust Pamela and Dwaine Kimmet The Kronthal Family Foundation Foundation Estate of Lillian Copperman Estate of Frank O. Fredericks Trust of Estelle Knapp The Jacob & Valeria Langeloth Trust of Edward G. Ryder The American Italian Cancer Carlos A. Cordeiro Foundation The Fribourg Foundation Trust of Paul and Fran Knight Foundation The Raymond & Beverly Sackler Fund Foundation Estate of Leonard Cossack Estate of Gerard M. Friedman Joel Koschitzky Trust of Charles T. Larus for the Arts and Sciences The Ametek Foundation, Inc. The Cowles Charitable Trust Estate of Leonard Galasso Mr. and Mrs. Marvin H. Koslow Lazard Capital Markets Estate of George W. Schneider III Dorothy A. Anderson Chandler Cox Foundation Estate of Regina M. Gallichio The Fred W. Kramer Charitable Trust The Lerner Foundation Estate of Alana M. Schuster Anonymous Estate of Mary O. Craft Estate of Norman D. Galloway Cheryl Gordon Krongard Estate of Anne Leventon The Beatrice & Samuel A. Seaver Estate of Anita S. Appel Estate of Edna W. Curl Mr. and Mrs. Robert M. Gardiner Trust of Walter C. Kronke Dr. Nancy Alpern Levin Foundation Mr. and Mrs. Frank W. Appleton, Jr. Filomen M. D’Agostino Trust of Esther B. Garnsey Estate of Harriette H. Kussin Life Raft Group The Seraph Foundation Arms Wide Open Childhood Cancer Foundation Corp. Estate of Mildred B. Gehrke Estate of Sidney Lacher Trust of Martin C. and The Shen Family Foundation Foundation Trust of DeWitt S. Davidson Leonardo Giambrone The Lakeside Foundation Margaret V. Lohsen Trust of William and Isabelle Sherlock Joyce Ashley Trust of Richard L. Davies The Albert and Pearl Ginsberg Mr. and Mrs. Joseph M. La Motta Trust of Louis J. Lombardi Evelyn R. Simmers Charitable Trust Estate of Rose Ashton-Irvine The Arthur Vining Davis Foundations Foundation Estate of Harriet L. Lampert Mr. and Mrs. Edward Lundy Trust of Barbara K. Snader Avon Foundation Estate of Frederick W. Davis Liane Ginsberg Vivian F. Laube Earle I. Mack Foundation The Society of MSKCC Associates Estate of William C. Bahn, Jr. Estate of Leonard Davis The Glades Foundation Lavelle Fund for the Blind, Inc. Estate of Lucille Knowles Committee The Banbury Fund Trust of Marion E. Dean Alfred G. & Hope P. Goldstein Fund Betty Reid Lawson Freedman Mann Estate of Katherine R. Sonneman Estate of Florence Barrack Trust of Carolyn B. Denney Susan Wallack Goldstein The Iris and Junming Le Foundation The Lois H. Mann Charitable Spin4Survival Estate of Marcia Batten Hester Diamond Foundation Estate of Barbara Grace Lead Annuity Trust Foundation The John R. and Inge P. Stafford Betsy L. Battle The Dickson Foundation Granary Associates Trust of Joseph Lebednik March of Dimes Foundation Foundation Estate of Grace Becker The DiMenna Foundation, Inc. Grand Street Fund The Richard S. and Karen LeFrak Estate of Anne Markowitz Estate of Helen E. Steadman Estate of Ethel A. Bell Elizabeth R. Miller and James G. Dinan Mr. and Mrs. Alan I. Greene Charitable Foundation Trust of Anthony J. Masard Bonnie and Steven E. Stern Trust of Virginia Poole Benjamin and The Dinan Family Foundation Grinberg Family Foundation In memory of Stacey Leondis Trust of John C. McCormick The Mel Stottlemyre Myeloma Estate of Irma Berg Elizabeth K. Dollard Charitable Trust Virginia and Howard Groombridge Estate of Donald LeRoy The James S. McDonnell Foundation Foundation Bergstein Family Foundation William C. Dowling, Jr. Foundation Mr. and Mrs. Martin D. Gross Mr. and Mrs. Allan L. Levey Estate of Ralph Melson Mr. and Mrs. Paul A. Street Estate of Gertrude G. Bernstein The Walter S. and Lucienne B. Driskill Robert C. Halboth Fran and Ralph Levine Estate of Ruth Vitow Messias Trust of James Strobridge The Bie Family Foundation Foundation Mrs. Melville W. Hall Trust of Leona Levy J. P. Morgan Chase The Michael Sweig Foundation The Lisa E. Bilotti Foundation Mr. and Mrs. Barclay Ehrler Trust of Florence M. Hammer The Anne Boyd Lichtenstein The Norman M. Morris Foundation The Craig D. Tifford Foundation, Inc. The Nancy and Robert S. Blank Eli Lilly & Co. Gladys and Roland Harriman Foundation Trust of Paula Moss Trust of Irving Tirkfield Foundation Rita H. Schaefer Elliott Foundation Estate of Helen Lieber Mr. and Mrs. Charles H. Mott Barbara Davies Troisi Foundation Trust of Ronald M. Blau The Charles Engelhard Foundation Susanne and Shelley Harrison Estate of John E. Liebmann Muscular Dystrophy Association Estate of Stanley F. Tucker Estate of Ida Bloom Mr. and Mrs. Israel Englander Mr. and Mrs. Robert L. Harteveldt Pauline H. Lin 56 57

DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING

Live4Life Foundation Parfums de Coeur Ltd. The Grace, George, and Estate of Ruth Whitfield Trust of Eileen L. Batten Janna Bullock Harry J. Lloyd Charitable Trust PepsiCo Foundation, Inc. Judith Silverburgh Foundation The Helen Hay Whitney Foundation The Modestus Bauer Foundation Trust of Florence Bunn Estate of Marian J. Looser Estate of Ann Perkins Trust of Leonard & Ruth Silverman Mr. and Mrs. Frank C. Whittelsey III Estate of Thelma Beatty Tory Burch Lung Cancer Research Foundation Estate of Claude E. Petruzzi Leonard and Donna Simon The Jesse R. Wike Charitable Trust Trust of Gertrude E. Beck Mr. and Mrs. Franz H. Burda Estate of Julian Malkiel Pin Down Bladder Cancer Trust of Angie S. Skinner Mr. and Mrs. Sam Wilderman Mr. and Mrs. Edmund Becker Mrs. Coleman P. Burke Manhasset Women’s Coalition Against Mr. and Mrs. Jeroen Henk L. Pit The Gordon H. and Norma Smith Kendrick R. Wilson III Rosalie Becker Estate of Louise V. Burnett Breast Cancer Jean D. Pitcher Family Foundation Trust of Vincent J. Zappolo Estate of Charles R. Beechler Mr. and Mrs. Harold Busch Estate of Albert Manning Josephine K. Poling Estate of Robert A. Smith Estate of Robert E. Ziegler Estate of Robert D. Bennett Estate of John D. Bush Estate of Marvin Margolies Polo Ralph Lauren Corporation Roberta A. Smith Deborah A. Zoullas Corinne Berezuk and Michael Stieber Mr. and Mrs. Jonathan J. Bush Mrs. John L. Marion Estate of Elizabeth Polotaye Estate of William E. Snee Nicholas B. Zoullas Mr. Bernard S. Berkowitz The Paul Nabil Bustany Foundation Trust of Sarah H. Marks Trust of Helen M. Price Ms. Beryl Snyder Joan and James Berkowitz Fund Gilbert and Ildiko Butler Family The Marmot Foundation Estate of Seymour Price Society of Interventional Radiology $100,000 — $249,999 Estate of Tony P. Bernabich Foundation, Inc. Estate of Edith Lipphardt Martens Project A.L.S. Foundation A & P Foundation The Bill Bernbach Foundation Estate of Marian Butler Estate of Elizabeth Martin Prudential Financial, Inc. Roy M. Spear Foundation Abbott Laboratories Steffi and Robert Berne Estate of Ruth J. Butterworth Trust of Richard and Betty Martin Mrs. Jenice Pulver The Seth Sprague Educational and The Louis & Anne Abrons Mrs. Louis Bernstein Estate of Lillian A. Byman Estate of Ann L. Martinez Purdue Pharma LP Charitable Foundation Foundation, Inc. Bid-Service LLC Mr. and Mrs. Bruce L. Calhoun The Lucille and Paul Maslin Foundation Patricia A. Quick Charitable Trust Trust of James L. Stackhouse Mr. and Mrs. Laszlo Adam Estate of Margaret L. Bingman Trust of Marilyn Campbell Trust of Cecelia Matarazzo Trust of Harriet C. Rath The Robert Steel Foundation for Dr. Miriam and Sheldon G. Adelson Biomet Cancer Research & Treatment Fund Estate of Harry H. Maus Trust of Anne Ressner Pediatric Cancer Research Medical Research Foundation Trust of C. June Bisplinghoff Leah Rush Cann Max Cure Foundation Estate of Walter E. Rex III Trust of Frederick T. Steinberg The Francis X. Ahearn, Sr. Foundation BJ’s Charitable Foundation James A. Cannon The Mayday Fund The Rice Family Foundation The Jeffrey Steiner Family Foundation Daniel G. Alexander Trust of Raymond Blake Estate of Edward A. Cantor Mr. and Mrs. Louis V. Mazzella The Andréa Rizzo Dance Therapy Fund Mr. and Mrs. Howard Stern Robert and Elaine Allen Blaker Family Fund Caring for Carcinoid Foundation MBNA America Bank Trust of Lillian Robbins Trust of Charles M. Stevenson Alliance for Life Sciences & Health Alexander Blass Mr. and Mrs. Edmund M. Carpenter The MBNA Education Foundation Robin Hood Foundation Estate of Sonia Stolin-Moresco Estate of Lori S. Alper Bill Blass Licensing Company, Inc. Mr. and Mrs. Warren E. Carpenter III Donald J. McCarraher Estate of Sandra Sheppard Rodgers Mr. and Mrs. Scott Stuart Mr. and Mrs. Robert I. Alpern Dr. and Mrs. Alan S. Blinder Estate of William K. Carson Mary Jane McCarthy Estate of Nathan Rothstein The Daniel P. Sullivan Clinical The Amaturo Foundation, Inc. Ambassador and Mrs. Alan J. Blinken Mr. and Mrs. William M. Carson The Michael W. McCarthy Foundation Estate of Wilhelmina T. Rouget Fellowship Fund The American Ireland Fund Mr. and Mrs. James A. Block Colon B. Carter Mr. and Mrs. Jay H. McDowell The Selma and Lawrence Ruben Timothy P. Sullivan Charitable Amgen, Inc. Estate of Vivian K. Blonder Trust of Winifred T. Carter Estate of Charles McGreevy Foundation Lead Trust Estate of Maurice Amzalak The Walter & Adi Blum Foundation, Inc. Estate of Elsie Cartotto Mr. and Mrs. Thomas E. McInerney Mrs. Orhan I. Sadik-Khan J. T. Tai & Co. Foundation Mr. and Mrs. Harold F. Anderson Trust of Eli Blumenfeld Joan (Perkowski) Cashin Foundation Estate of Donald G. McKeon Mrs. Edmond J. Safra Ping Y. Tai Foundation Warren and Lillian Anderson Harold and Adele Blumenkrantz Casual Male Corp. Estate of Alan McMaster Dr. Nathan E. Saint-Amand Frank N. Tedesco Anonymous Estate of Simon P. Blustone The Cayuga Foundation MeadWestvaco Corporation Mr. and Mrs. Herbert E. Saks Estate of Ida Tepper Mr. and Mrs. Jerome V. Ansel Bruce Bocina Estate of Charlotte A. Celian The Merck Company Foundation Mara and Ricky Sandler Trust of Annette M. Terdina Estate of Mark J. Anton Estate of Marti A. Boden Trust of George F. Chagnot Mesothelioma Applied Research Fund Trust of Erika Saphier Estate of Stella R. Thater The Antonacci Family Foundation Estate of Marjorie R. Boselly Dr. Kalpana Chakraburtty Estate of Despina Messinesi Trust of Paul C. Sawyer Thrasher Research Fund Mr. and Mrs. Rand V. Araskog Alan F. Bovee Chanel, Inc. Trust of Russell A. Meyer Trust of Edwin & Grace Sayers Mr. and Mrs. Carl W. Timpson, Jr. Mr. and Mrs. William J. Armfield IV William R. Boyle Margaret Anne Chappell Peter Michael Foundation Estate of Christine C. Scanlan Estate of Michael Z. Toman Kym S. Arnone Estate of Mary C. Brabson Estate of Camille Chericone Trust of Russell H. Michel Trusts of Anabel M. Scarborough and Mr. Steven Trost The Aronson Family Foundation Estate of Elsie L. Bradford Child Neurology Foundation The Milbank Foundation for Walter L. Scarborough The Tyler Foundation Mary Kay Ash Charitable Foundation Brahman Capital Childhood Brain Tumor Foundation Rehabilitation The Milton Schamach Foundation, Inc. Trust of Irwin C. Unger The David R. and Patricia D. Atkinson Brain Tumor Funders’ Collaborative The Children’s Brain Tumor Foundation Mrs. Minot K. Milliken Mr. and Mrs. Stephen Scherr United Hospital Fund of New York Foundation Anna M. and Mark R. Brann Children’s Neuroblastoma Cancer Estate of Dorothea K. Money Trust of Jennie C. Schneider United Leukemia Fund Inc. The Isaac and Carol Auerbach Family Mr. and Mrs. Henry R. Breck Foundation Young Ae Lim and Joonsikk Moon Mrs. Silvia A. Schnur United Way of New York City Foundation Milton Brenner The Francis and Miranda Childress Trust of Anny S. Moore Estate of Evelyn Schrank The Lucy & Eleanor S. Upton Autism Speaks Estate of Mae Bridewell Foundation Ronald and Brenda Morey Trust of Crystal Schull Charitable Foundation Aviesan French National Bridgemill Foundation The Jane Coffin Childs Memorial Fund Trust of Edmund L. Murray Estate of Bertha Schulman The Vasey Foundation B*Cured The Brightwater Fund, Gloria Jarecki for Medical Research The National Brain Tumor Society The Schultz Foundation Vital Projects Fund, Inc. Trust of Maureen E. Bacchi Trust of Marie H. Brock Mr. and Mrs. Allen Chipman Carole and Raymond Neag Searle Scholars Program Estate of Eleanor B. Vogel Dr. Joseph J. Bailey Estate of Edna Brodie Florence Chu, MD Trust of Louise F. Neely The Select Equity Group Foundation Douglas Walker Elliot A. Baines Randall Brooks Estate of Selma Chyatt Craig H. Neilsen Foundation The Nina and Ivan Selin Family The Washington Post Company The Baird Family Fund Carl and Nickey Brown William Joseph Ciliberti Estate of Ann M. Nelson Foundation The Wasily Family Foundation Gail L. Baird Catherine D. Brown Judith Ann Cion Revocable Trust Muriel Neumann Seventh District Association, Inc. The Bert & Sandra Wasserman David M. and Barbara Baldwin Brown Helicopter, Inc. Estate of Piera Circiello New York Workers’ Compensation Bar Estate of Gladys N. Severud Foundation Estate of Harold P. Bannister Trust of Ruth Ann Brown Amanda Styles Cirelli Foundation for Association The Shanken Family Foundation Marla J. Wasserman Mr. and Mrs. Robert L. Barbanell Estate of William A. Brown, Sr. Pediatric Cancer Research The Newport Foundation Estate of Odette Sharow The Scott Weingard Memorial Fund Trust of James R. Barber Mr. and Mrs. Norman Brownstein The Anne L. and George H. Clapp Trust Estate of Jane M. Nicholson Trust of Minnie M. Shaw Estate of Elias Weiss Trust of Margaret D. Barber The Honorable Tina Brozman Estate of Lyman W. Clardy James G. Niven Hope Sheridan Foundation Effie Wells-Lonning Barish Family Foundation Foundation Cleveland Clinic Health System The Okonite Company Nancy Shevell Trust of Ida Wharton Trust of Grace M. Barry Estate of Vernon Brunelle CLL Global Research Foundation Grace Oughton Cancer Foundation Renee and Irwin Shishko Whitehall Foundation Estate of Kaethe F. Barry Elizabeth Bucher The Coca-Cola Company Eileen and James A. Paduano Estate of Lillian M. Siemionko John C. Whitehead Estate of Patricia A. Barry The Peter & Carmen Lucia Buck Clarence L. Coleman Jr. and Foundation Lillian S. Coleman Foundation 58 59

DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING

James J. Coleman, Jr. Percy S. Douglas Mr. Edward W. Frantel Allen J. Grubman Hope V. Hofmann Thomas F. Kearns Paul Jackson Coleman Susie M. Downing Frazier Foundation Audrey and Martin Gruss Foundation Mrs. Carolyn T. Holden Mr. and Mrs. Brian G. Kelly Estate of Gertrude T. Coles Trust of Max Drechsler Estate of Katherine Freeman Estate of Wanda Grzymala Estate of Lillian E. Holdren Estate of Ruth C. Kelly Robert and Maryann Collin Jane Clausen Drorbaugh Frey Family Foundation, Inc. Mr. and Mrs. Roberto de Guardiola Trust of Burt Holtzman Mrs. Ann Kelman and the late Arthur R. Collins Dr. Scholl Foundation Zoltan Fried Guardsmark, LLC Howard and Carol Holtzmann Dr. Charles D. Kelman Estate of Lila V. Collins Dr. Jeffrey Duban Knawm Friedman Marilyn B. Gula Mountains of Hope Estate of Herman L. Hoops Eleanora and Michael Kennedy Terry Collins Trust of Patricia P. Duffy The Anna Fuller Fund Foundation Hope Funds for Cancer Research Peter Kenner Family Fund The Colon Cancer Foundation Estate of Doris M. Dunham Richard M. Furlaud Estate of Pauline R. Gulau Alfred Samson Hou J. Kevin Kenny Mr. and Mrs. Alexius Conroy Margaret H. Dunwiddie Mr. and Mrs. Thomas J. Gahan Trust of Elizabeth Guon Robert Howard Family Foundation John A. Kent Consolidated Edison Company The Durst Organization, Inc. Trust of Ralph W. Gaines Estate of Gloria E. Gurney Evelyn Huber Estate of Herman Kerner of New York Estate of Laura D. Eastman Estate of Anne Gallagher Gurney Foundation Estate of Frank Huber The Glenn D. Kesselhaut Dudley P. Cook The Eberstadt-Kuffner Fund Inc. Estate of Maud Gallagher Mimi and Peter Haas Fund Nancy Hughes Children’s Joy Fund Mr. and Mrs. Errol M. Cook Richard Edelman The Gateway for Cancer Research Hachette Filipacchi Media U.S. Edna Hunt Estate of Mary F. Kessler Mrs. William B. Cook Doris M. Edwards Trust of Louis C. Geiger Jayma Meyer Hack and Bruce L. Hack Carol Hunter Mr. and Mrs. Peter A. Kessler Cooley’s Anemia Foundation E. E. Cruz Company Trust of William G. Genner, Sr. The Hagedorn Fund James B. Hunter Coyla E. Ketchy E. Gerald Cooper Mr. and Mrs. Blair W. Effron Kara and Peter Georgiopoulos The Laverna Hahn Trust Syde Hurdus Foundation, Inc. The Kettering Family Foundation Estate of G. R. Couch Trust of Bertram Ehrlich Robert & Sylvia Gergen Estate of Margaret S. Hahn Hyundai Motor America Estate of Henri Khouri Courtesy Associates, Inc. Trust of Raymond Ehrlich Panayotis Gerolymatos Martin and Deborah Hale I Back Jack Foundation, Inc. Doris and Floyd Kimble Foundation Estate of Edith C. Cox Estate of Elinor Ehrman The Patrick A. Gerschel Foundation Estate of Elizabeth W. Hall Mr. and Mrs. David W. Ichel The King Family Charitable Lead Trust Trust of Franklin C. Craig Estate of Estelle Eisenstat Estate of Theresa A. Ghiringhello Estate of Mazie J. Hall Estate of Priscilla T. Iden Mr. James W. Kinnear II Trust of Louise Crites Mr. and Mrs. Frederick Elghanayan Marlene and Alan Gilbert Estate of Helen Sue Hameetman Inamed Corporation Patricia A. Kirby The Crown Family Martin Elk League for Cancer Research Mrs. Bruce A. Gimbel Milton and Miriam Handler Foundation Incyte Corporation David L. Klein, Jr. Foundation Bruce Crystal Trust of Arnold B. and Joan S. Elkind Mr. and Mrs. William H. Girvan Trust of Robert Hanson Ingersoll Rand Company Robert D. Klemme Cure Childhood Cancer Mr. and Mrs. Richard S. Emmet Mr. and Mrs. Eugene J. Glaser Estate of Marion K. Hardwicke Mr. and Mrs. William H. Ingram The Esther and Joseph Klingenstein Mr. and Mrs. James F. Curtis III Empire Blue Cross & Blue Shield Glenwood Management Corporation Mr. and Mrs. Jose Kuri Harfush The Interpublic Group of Companies Fund Custom Design Communications, Inc. Andrew J. Entwistle Trust of Glenn R. Gobble Dorothy Harlow Irish Society of Medical Oncology Fernand Koch William J. Cwenn Estate of Lillian Epps Mr. and Mrs. Bradley Goldberg Estate of Mary Jane Harrington Mr. and Mrs. Thomas C. Israel Estate of Gale K. Kokubu Estate of Thomas R. Daly Mr. and Mrs. Christopher Errico Leslie H. Goldberg Leonard B. Hart It Figures LLC Emanuel Kondoleon Rosetta B. Damilano Esophageal Cancer Education Trust of Marc S. Goldberg Perry Harten Harry A. Jacobs, Jr. The Koppelman Family Foundation Mrs. Charles A. Dana, Jr. Foundation The Goldhirsh Foundation Laura Hartenbaum Breast Cancer Jacobus-Iacobucci Foundation The Kors Le Pere Foundation Estate of Richard Daniels Rafael Etzion Estate of Elizabeth B. Golding Foundation Estate of Harold F. Jaeger The Gwen L. Kosinski Foundation The Gloria and Sidney Danziger Estate of Eugene M. Evans, Jr. Daniel S. Goldman Mr. and Mrs. William R. Hartong Mr. and Mrs. Stanley R. Jaffe Robert A. Kotick Foundation, Inc. The Evslin Family Foundation The Barbara L. Goldsmith Foundation Have A Chance, Inc. James Family Foundation Mr. and Mrs. Robert A. Kramer The E. S. P. Das Foundation Trust of James D. Ezzell Mr. & Mrs. Sidney Goodfriend Morris A. Hazan Family Foundation Trust of Ann E. Jennings Mr. and Mrs. Jerome I. Kroll Estate of Hazel Davidson Family Reach Foundation Trust of Manuel and Anne Goodman HCCF Foundation Richard H. Jenrette Trust of Grace E. Kruse The Ellen and Gary Davis Foundation Fanconi Anemia Research Fund The Gordon Family Foundation, Inc. Mr. and Mrs. Andrew P. Heaney The Jewish Communal Fund KVFF Fund Roxana V. Dawson Mr. and Mrs. Alfonso Fanjul, Jr. Christy and Sheldon Gordon Trust of Lonie G. Hearn The JMB Hope Foundation Estate of Sidney J. Lacher Estate of Jean Decker Mr. and Mrs. James T. Fantaci Arthur A. Gosnell Trust of Shirley S. Heiligman Mr. and Mrs. Peter James Johnson, Jr. Lake Road Foundation Estate of Libiro DeFilippis Estate of Marion E. Feigenbaum Trust of Louise S. Gosse Mr. and Mrs. Robert M. Hendrickson The Samuel C. Johnson Trust The Lakeside Foundation The Lawrence and Florence DeGeorge Gretchen V. and Samuel M. Feldman Marietta A. Goulandris Mr. and Mrs. John Hennessy J.P. Wish Fund Estate of Schubert L. Lamb Charitable Trust The Corinne Feller Memorial Fund Julie Gould Fund for Medical Research The Maxine R. and The Kahn Charitable Foundation Estate of Marvadene B. LaMonica Lynn DeGregorio Trust of Thelma F. Fernandez Estate of Richard P. Gould Richard L. Henry Trust Trust of Frank J. Kahn The Edward & Kinga Lampert Estate of Katherine C. DeHaan Goff Fetzer Institute Felice M. Grad Estate of Robert Hensel, Jr. Jane Kalmus Foundation Anthony Del Bove Trust of Lydia K. Fiedler Graff Diamonds Carolina Herrera, Ltd. Harry P. Kamen Family Foundation Emma Landau Estate of Helen Demitriades Gloria S. Fine Grantham Mayo Van Otterloo & Co. Trust of Leon Hershaft Mr. and Mrs. Daniel B. Kamensky Mr. and Mrs. Barry Lang The De Rosa Foundation for Colon Randee and Howard Fischer The Grateful Foundation, Inc. Ms. Marlene Hess and Mr. Jim Zirin Trust of Mildred Kaminsky Estate of Annie Langen Cancer Research and Prevention Estate of James K. Fisher Estate of Harvey R. Graveline Trust of Marie Hesselbach Estate of Eleanor Kane Estate of Anne Lanigan Ernst and Paula Deutsch Foundation Estate of William and Frederica Fissell Susan Zises Green Estate of Manny Hilfman Mr. and Mrs. William Kane J. Clair and Pamela Lanning The DeWitt Wallace Fund Trust of Loretta B. Fitzgerald Brigadier General and Mrs. William S. The Hillcrest Foundation Estate of Bernard Kantor Dr. Gerald D. Laubach Mr. and Mrs. Anthony Diaco Mr. and Mrs. Thomas M. Fitzgerald III Greenberg Hillenbrand Family Foundation Steve and Meghan Kanzer Mrs. Lois H. Lazaro The Miriam & Arthur Diamond The Francis Florio Fund of the New Mr. and Mrs. Peter S. Gregory Mrs. John S. Hilson Estate of Irving L. Kaplan Trust of Edwin S. Lee, Jr. Charitable Trust York Community Trust Mr. and Mrs. Melvin W. Griffin The Mark Hindy Charitable Foundation Marie H. Karger Mr. and Mrs. Thomas V. Leeds The Ernest & Jeanette Dicker Steve Forbes Estate of Edythe Griffinger Trust of Myfanwy Hinkle The Karma Foundation The Lefkofsky Family Foundation Foundation Richard N. Foster Trust of William C. Griffith, Jr. Estate of Vladimir Hladik Trust of Jerry Katz Lehman Brothers Inc. Estate of Richard I. Diennor Trust of Aida A. Foti Trust of Vernon H. Grigg James and Angela Ho Trust of Toby Katz Karen and James Lehrburger Discavage Family Foundation Four Seasons Hotel – New York Grodetsky Family Foundation Estate of Edward B. Hodge Katzman Family Foundation Mr. and Mrs. Lewis E. Lehrman Oliver S. & Jennie R. Donaldson Claire and Meyer W. Frank and Estate of Evelyn Gross Estate of Marion Hoffman Edward M. Kaufmann Trust of Martha B. Leigh Charitable Trust Leann Frank Charitable Foundation Estate of J. Stanley Gross Estate of Ruth M. Hoffman Trust of John Kaufmann, Jr. Estate of Helen Lesniewski Estate of Maurice A. Donovan Trust of Irene R. Frank Trust of Lambert J. Gross Trust of Steward B. Hoffman, Sr. Trust of Ralph W. Kaufmann The Leukemia & Lymphoma Society John R. Doss Helen Frankenthaler Foundation Trust of William Gross Hoffman-La Roche Inc. Mr. and Mrs. Robert M. Kavner Leukemia Research Foundation Michael Douglas and Mr. and Mrs. David Lee Frankfurt Estate of Anthony Grosso Deborah H. and Sigmar K. Hofmann Carl Michael Kawaja and Estate of Dina Levinsky Catherine Zeta-Jones Trust of Jill and Jayne Franklin Gwendolyn N. Holcombe 60 61

DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING

Elvire Levy Mr. and Mrs. Hamish Maxwell Alfred L. and Annette S. Morse Mr. Alessandro Pinto Sheldon Rose Trust of Robert E. Schwenk Estate of Erna T. Lewine Maynard Childhood Cancer Foundation Foundation Plastic Surgery Foundation Taryn Rose International Mr. and Mrs. John W. Scully The Bertha and Isaac Liberman The Helen & William Mazer Foundation Ken and Linda Mortenson Dorothy Ploeger Estate of Sylvia Rosenberg Estate of Jewel C. Seab Foundation, Inc. Mr. Michael Mazzucca Mr. and Mrs. George K. Moss Mr. and Mrs. Roy R. Plum Trust of Ilsa Rosenblum The Jean & Charles Segal Foundation Mr. and Mrs. Richard Lightburn Estate of Ann C. McBride Manuel and Mercedes Mosteiro Estate of Beatrice Pockrass Trust of Evelyn Rosenstein Mr. David Sekiguchi Mr. and Mrs. Linda Lipay Estate of Donald J. McCarraher Lisa and Marcelo Mottesi Estate of John E. Polek Jeffrey Rosenzweig Foundation for The Maryam and Hervey Seley Trust of Wilhelmina I. Lipfert Mr. and Mrs. Thomas McCullough Virginia M. Mueller Mr. and Mrs. Gerard Pompilio Pancreatic Cancer Research Foundation Ira A. Lipman Mr. and Mrs. Jeffrey A. McDermott Estate of Irving Mulde Janis Z. Porch Leo Rosner Foundation Rosemary Selky Lisa’s Heart Kids’ Cancer McDonald Financial Group Mr. and Mrs. Thomas W. Murphy II Trust of Ann C. Porterfield Mrs. Howard L. Ross R. B. Sellars Foundation Research Fund Ralph McDonough Ernest Muth Estate of Edna G. Potter Estate of Sylvia Ross Sephardic Hospital Fund – Medstar The Harold I. & Faye B. Liss Foundation The Dextra Baldwin McGonagle The Nash Family Foundation Estate of John A. Powers Estate of Eva L. Rothberg The Jacqueline Seroussi Memorial Mr. and Mrs. Martin Liss Foundation Edith L. Nathanson Trust of Ruth S. Prall Philip and Marcia Rothblum Foundation Foundation The Litterman Family Foundation Mr. and Mrs. Edward B. McKeough The National Genetics Foundation, Inc. Prevent Cancer Foundation Mr. and Mrs. Eric A. Rothfeld L. J. Sevin Julia Little The McKnight Endowment Fund for NBC Universal Rita Price Estate of Geraldine E. Rove Harold Shames Estate of Santina Livolsi Neuroscience Estate of Leslie A. Nelkin The Procter & Gamble Company Denise Rover Estate of Reuben Shane Demarest Lloyd, Jr. Foundation Estate of Geoffrey McLoughlin Trust of Jerome Nerenberg Estate of Ardys M. and Fran and Jeff Rowbottom Estate of Saul Shapiro Jeanette and Peter Loeb Estate of Mary E. McMaster New York City District Council of Harold I. Proctor Mr. and Mrs. Charles Royce The Sharma Foundation Long Island League to Abolish Cancer Mr. and Mrs. David B. McQueary Carpenters Relief and Charity Fund The William H. Prusoff Foundation Estate of Pearl Rubin Trust of Margaret S. Sharp Estate of Margaret S. Longwell The Meckler Foundation New York State Health Foundation Dr. and Mrs. Mark Ptashne Mr. and Mrs. Mitchell E. Rudin Estate of Bernice Baruch Shawl Estate of Anthony Lopez Melanoma Research Foundation Gerald L. Nichols and Robert Pufahl Estate of Maria Stella Ruggirello William R. Sheldon Milton Lowenstein Estate of Dorris M. Mendelsohn Jacqueline W. Nichols Foundation Richard I. Purnell Fund Estate of Katherine L. Rummler Estate of Alice Sherwin James J. and Marianne B. Lowrey Estate of Irving M. Mendelson Trust of Robert F. Novak Estate of Richard I. Purnell Estate of Eileen B. Ruthrauff Estate of Leo A. Shifrin, MD The Lucerne Foundation Estate of Lorraine Mensing NYS Fraternal Order of Police Bambi Lyman Putnam The Derald H. Ruttenberg Foundation Mr. and Mrs. Stanley B. Shopkorn Cynthia and Dan Lufkin The Reuven Merker Charitable Foundation Roselyn Flaum Radcliffe Trust of Anne I. Ryan Mr. and Mrs. William Shulevitz Ronald S. Lux Foundation, Inc. The Michael A. O’Bannon Foundation Trust of Samuel J. Radcliffe, Jr. Andrew Sabin Family Foundation Mr. and Mrs. Steven J. Sidewater Mr. and Mrs. Alexander P. Lynch Estate of Amy Joan Meskin Estate of Ernestine A. O’Connell Stewart Rahr Martin Sabowitz and Muriel Goldrich Muriel F. Siebert Foundation Trust of John F. Lynch Mr. and Mrs. Frank A. Metz, Jr. Mr. and Mrs. Jeremiah O’Connor Trust of Betty Raiff Moise Safra Family Estate of Ruth Siegmann Estate of Kathleen E. Lynch Mr. Robert A. Metzler Trust of Emily C. O’Grady Muriel Rains The Saibel Foundation Estate of Mary Siekert Estate of Charles S. Lyons Estate of Abby E. Meyer Estate of Grace O’Hare Mary L. Ralph Philanthropic Fund Mr. and Mrs. Francois de Saint Phalle Trust of Walter Silberfar Estate of Melvin E. Lyons Estate of Ursula Meyer The Oceanic Heritage Foundation John H. Rassweiler Estate of V. Edward Salamon Mr. and Mrs. Robert H. Silver MacDonald-Peterson Foundation The Emanuel N. Micallef Foundation Oki Data Americas, Inc. Abigail T. Reardon Mr. and Mrs. Eugene L. Salem The Slomo & Cindy Silvian Foundation Mr. and Mrs. Duncan MacMillan Mrs. Sidney Michael Mr. and Mrs. John D. Opie Estate of Phyllis E. Redmerski Mr. and Mrs. William R. Salomon The Seymour Simon Charitable Trust Josiah Macy, Jr. Foundation Trust of William M. Michaelson Optiscan Elenore Reed Trust of Sidney Samuels Marilyn M. Simpson Charitable Trust The Arthur and Holly Magill Foundation Trust of Florence B. Mickels Estate of Elaine Orbach Estate of Martha Cuneo Reed Henry Sanborn Simpson Thacher & Bartlett Trust The Maguy Foundation The Mike and Steve Foundation Otis Elevator Company Samuel P. Reed Estate of Andrew D. Sanders Trust of Marie A. Sinclair Estate of Margaret E. Maihl Elaine P. Miles The William & Jane Overman Compton Rees, Jr. The Sandler Family Trust of Otto K. & Harriet J. Singer Estate of Margaret H. Mairs Eleanor F. Miley Foundation The Beatrice Renfield Foundation Nina and Julian Sandler Estate of Shirley Singer Maite Aquino Memorial Fund Carolyn Rosen Miller Family Mr. and Mrs. Gunnar S Overstrom III Mr. and Mrs. Ira L. Rennert Charitable Fund Estate of Madeline Sisia Estate of Mariette P. C. Major Foundation Mr. and Mrs. Neil Padron Olivier and Yosun Reza Mrs. Barbara Santangelo Estate of Evelyn M. Skolnick Herbert J. Maletz Mr. and Mrs. Donald K. Miller Pam’s Pals Inc. Estate of Roland S. Rhode Sarcoma Foundation of America SL 2005 Family Trust Mr. and Mrs. Irving H. Malitson Mr. and Mrs. Larry J. Miller Daniel P. and Nancy C. Paduano Family Judy Rhulen and Family The Sass Foundation for Medical The Alan G. Slifka Foundation Elissa Caterfino Mandel Mr. and Mrs. Matthew Miller Foundation Martin Rich Research Estate of Alvin F. Sloan Estate of Harry Marder Mr. and Mrs. Richard A. Miller The Parnassus Foundation Anne S. Richardson Fund The Saw Island Foundation Dr. and Mrs. Bernard E. Small Estate of Ida Mae Margolis Mrs. Mary E. S. Milligan Trust of Edith Pattison Trust of A. Leslie Richardson Estate of Ida M. Scagliarini Suse Smetana Trust of Carlton G. Marie Mr. and Mrs. James W. Milton Estate of Herman L. Paul, Jr. Dee Dee Ricks Scalamandré Silks The Randall and Kathryn Smith Mr. and Mrs. Bernard Marin Estate of Dorothy B. Minard Mr. and Mrs. Kenneth Pearlman Estate of Harry Rinehimer Didi and Oscar S. Schafer Foundation Edward J. Marino Melissa and Robert Mittman Richard S. Pechter Estate of Elizabeth M. Ringo Peter L. Schaffer Mr. Robert J. Smith Susan and Morris Mark Leslie M. Modell Pediatric Brain Tumor Foundation Trust of Victoria Rinius Estate of Richard Scharff Estate of Woodrow Q. Smith Jerome S. and Maria Markowitz Estate of Catherine Mohan Pells-Mayton Foundation The Fannie E. Rippel Foundation Estate of Josephine L. Schiff Estate of Dorothy Smolen Zvi and Linda Markowitz Estate of Irene Mokrzycki Trust of James A. Pemberton Estate of Norma Risman Estate of Billie Schneider Catherine M. Smolich Estate of Benjamin Marmer Trust of Celestine Elizabeth Moloney Mrs. Richard T. Perkin The Ritter Family Foundation Mr. and Mrs. Robert Schneider Trust of Robert J. Smutny The Christina & Paul Martin Foundation Estate of William Monaghan Mort Perlroth Irene Ritter Foundation The Schneider-Kaufmann Mr. and Mrs. Jay T. Snyder Mr. and Mrs. Roman Martinez IV Arthur R. Montgomery Lisa and Richard Perry Abigail Rittmeyer Foundation, Inc. The Harry & Estelle Soicher Foundation Dorothy Marx John and Hee-Jung Moon Pershing Square Foundation The RMF Family Fund, Inc. Mr. and Mrs. Paul C. Schorr IV Trust of Robert Solnick Estate of Johanna Marx Estate of Pauline Moor Estate of Frederick D. Petrie Mr. and Mrs. Stephen Robert Trust of Lola Schug Professor and Mrs. C. Alan Soons Estate of Rita B. Masse Mr. and Mrs. Charles V. Moore The Pew Charitable Trusts Bernard and Elaine Roberts Estate of Harold B. Schwartz Soros Fund Charitable Foundation James Mathos Estate of Percy W. Moore Mr. Donald Pfanz Estate of Floyd B. Roberts Theodore G. Schwartz Family Sotheby’s The Hale Matthews Foundation Tom & Judy Moore Foundation Samantha and Ernst Pfenninger Vivien Rock Foundation Trust of Henry Spenadel Trust of Walter J. Matthews Estate of Barbara B. Morgan Trust of Peter H. Pflugk Rodale, Inc. Estate of Rosalind Schwartzbach Estate of Regina W. Spence The Matt’s Promise Foundation Yvonne & Arthur Moretti Trust of Charles V. Pickup Estate of Maria Rolfe Trust of Paul J. Schwarz Alvira R. Spencer Maverick Capital Charities Melissa and Chappy Morris Estate of Irene Pickup Vittorina Rolfo Mrs. Arline Schwarzman Estate of DeAnne Spencer 62 63

DONORS TO THE CAMPAIGN FOR MEMORIAL SLOAN-KETTERING Produced by Estate of Agnes Spillmer Estate of Rita L. Tracey Estate of E. Olga Wesner The Department of Public Affairs The St. Giles Foundation Trust of Helen A. Trahin Mrs. Elizabeth G. Weymouth Memorial Sloan-Kettering Ronald Stafford Cancer Support Trust of Dorothy B. Traufield When Everyone Survives Cancer Center Foundation, Inc. Beatrice Travis-Cole Estate of Frank A. Widenski 1275 York Avenue Staten Island Yacht Sales, Inc. The Robert Mize & Isa White Trimble Nancy P. Widmer New York, NY 10065 Esta Eiger Stecher Family Foundation Mr. and Mrs. Gene Wilder Mr. and Mrs. Edward C. Steele The W. James & Jane K. Truettner The Wilf Family Foundation t 212-639-3573 Estate of Sanford L. Steelman Foundation Andrea J. Will Memorial Foundation f 212-639-3576 Estate of Dennis Stein Thomas N. Tryforos Barbara F. Williams [email protected] The Fred & Sharon Stein Foundation Estate of Ina Tuckman Williams Trading LLC Mrs. Nancy Steinfeld Estate of R. Read Tull Trust of Helen A. Wilson The Ernest E. Stempel Foundation Lucien L. and Shirley Turk Mr. and Mrs. Jon Winkelried Estate of Irene Stern Ahavas Tzedek Foundation James B. Wittrock Avice A. Meehan* Estate of Winona H. Stevens David V. Uihlein, Sr. The Henry Wolf Foundation Vice President, Communications, and The Guy M. Stewart Cancer Fund Mr. and Mrs. Mark D. Unger Trust of Toby Wolfberg Chief Communications Officer, MSKCC J. McLain Stewart The Valley Foundation Mrs. Barbara Wolfson *As of January 7, 2013 Estate of Rebecca Stohl Valley of the Sun United Way Estate of Gordon Wootton Mr. and Mrs. Stuart P. Stoller Estate of June A. Vanderpool Deborah C. Wright Anne B. O’Malley Mr. and Mrs. Norman L. Stone The Varnum DeRose Trust Trust of Twylia H. Wright Executive Director, Public Affairs Estate of Clair B. Stough Dr. Terry G. Vavra and Linda F. Vavra Estate of Bernadette Wyrough Trust of May Strang Veejay Foundation Estate of Arthur P. Young Estate of Gene K. Strange The Victoria’s Smile Foundation Alfred D. Youngwood Writers Estate of Herta Strauss Trust of Eva Vida The Patricia J. and Edward W. Zeh Celia Gittelson Geraldine Stutz Trust Inc. The Family of Maria Elena Villanueva Charitable Foundation Julie Grisham Trust of Mary R. Suchanski Estate of Dorothy Voelker The Zickler Family Foundation Esther Napolitano Mr. and Mrs. Robert J. Sullivan Trust of Anna L. Vogel The Isaac Ziegler Charitable Trust Allyson T. Collins David W. Sussman Estate of Gertrude Vogel Stanley Shalom Zielony Foundation Phyllis and Bernard Sussman Voices Against Brain Cancer Martha E. Zimmer Contributors Estate of Sandra Syms Foundation Larry and Anne Zimmerman Dorothy D. Taggart Trust Trust of Beverly Wachtel Mr. and Mrs. Jeffrey A. Zucker Anne Clear The Paula Takacs Foundation for Wachtell, Lipton, Rosen & Katz Ha Ly Sarcoma Research The Paul E. and Mary Wagner Trust Joe Pisarchick James R. Tanenbaum and Estate of Lillie M. Waldon Christina Pernambuco-Holsten Elizabeth M. Scofield Mr. and Mrs. Paul D. Walsh Trust of Andrew Taras Estate of Frances M. Wanek Photography Trust of Joyce A. Taras Estate of Shirley I. Warner Edward Tarby The Warner Foundation, Inc. Matthew Septimus Target MarkeTeam, Inc. Warren/Soden/Hopkins Family Juliana Thomas Estate of Ruth N. Taub Foundation Tay-bandz, Inc. Mr. and Mrs. Bruce Wasserstein Additional Photography Estate of Florence G. Taylor Elizabeth T. Wassmundt Richard Dewitt Estate of Gertrude S. Taylor Estate of Shirley F. Watkins Mario Morgado Team Connor Cancer Foundation Jesse and Doris Weaver Team Luke vs. Neuroblastoma Mr. and Mrs. Peter Webster Telethon Italy – US Foundation Mr. and Mrs. Bradford G. Weekes III Design Estate of Walter G. Terwedow Mr. and Mrs. John G. Weiger Ideas On Purpose, NY Think Pink Rocks Trust of Gertrude H. Weiler www.ideasonpurpose.com Mr. and Mrs. Andrew S. Thomas Mrs. John L. Weinberg Estate of Robert P. Thome Marc S. Weinberger Printing Trust of Vernon Thompson Danny M. Weinheim Allied Printing Services The Vernon F. & Mae E. Thompson The Isak & Rose Weinman Charitable Foundation Foundation, Inc. Thrill Hill Productions Mr. and Mrs. Michael Weisberg Front Cover Image Estate of Margaret R. Tomas Andrew and Ronnie Weiss Plastic and reconstructive surgeon Estate of Milton Topolsky Estate of Gertrude Weiss Joseph J. Disa collaborates with Estate of John J. Tormey In memory of Marie T. Weiss Chief of the Orthopaedic Service The Tortuga Foundation John A. Weissenbach and John H. Healey. Estate of Virginia M. Toth Ann Southworth Trust of Angelina Ann Tovar Trust of Gertrude Wellisch Mr. and Mrs. David C. Tracey The Nina W. Werblow Charitable Trust © Copyright 2013 Jill Tracey Virginia A. Werner Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York, NY 10065

212-639-2000 General Information

800-525-2225 Physician Referral Service

www.mskcc.org Visit us online

facebook.com/sloankettering twitter.com/sloan_kettering youtube.com/mskcc

www.mskcc.org/annualreport DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Medical Board as of March 15, 2013 Department of Epidemiology and Biostatistics as of March 15, 2013

David R. Artz, MD Hedvig Hricak, MD, PhD Esperanza B. Papadopoulos, MD ATTENDINGS ASSOCIATE ATTENDINGS Shari Goldfarb, MD Colin B. Begg, PhD Lewis J. Kampel, MD Melissa S. Pessin, MD, PhD Peter B. Bach, MD Elena B. Elkin, PhD Alexia E. Iasonos, PhD George J. Bosl, MD Nancy A. Kernan, MD David G. Pfister, MD Jonine L. Bernstein, PhD Yuelin Li, PhD Allison N. Lipitz-Snyderman, PhD William S. Breitbart, MD Maureen Killackey, MD Simon N. Powell, MD, PhD Mithat Gönen, PhD Chaya S. Moskowitz, PhD Susan Oliveria, ScD, MPH Kevin Browne, RN Aileen Killen, PhD, RN Paul J. Sabbatini, MD Glenn Heller, PhD Sara H. Olson, PhD Irina Ostrovnaya, PhD Michelle Burke, RN David S. Klimstra, MD Leonard B. Saltz, MD Malcolm C. Pike, PhD Irene Orlow, PhD Sujata Patil, PhD CHAIR Ephraim S. Casper, MD Charles D. Lucarelli, RPh Rori Salvaggio, RN CHAIR AND ATTENDING Chris Sander, PhD Katherine S. Panageas, DrPH Li-Xuan Qin, PhD José T. Baselga, MD, PhD Lisa M. DeAngelis, MD Kathryn Martin Charles L. Sawyers, MD Colin B. Begg, PhD Venkatraman E. Seshan, PhD Jaya M. Satagopan, PhD Talya Salz, PhD Eugene W. Kettering Chair Joseph O. Deasy, PhD Mary Jane Massie, MD Peter T. Scardino, MD Andrew J. Vickers, DPhil Howard T. Thaler, PhD Ronglai Shen, PhD Dawn P. Desiderio, MD Mary McCabe, RN Craig B. Thompson, MD Ann G. Zauber, PhD Camelia S. Sima, MD Mary Dowling, RN Elizabeth N. McCormick, MSN, RN Martin R. Weiser, MD ASSISTANT ATTENDINGS Zhigang Zhang, PhD John R. Gunn Larry Norton, MD Roger S. Wilson, MD Victoria S. Blinder, MD Philip H. Gutin, MD Eileen O’Reilly, MB, BCh, BAO Marinela Capanu, PhD INSTRUCTOR William Hoskins, MD Richard J. O’Reilly, MD Sean M. Devlin, PhD Jennifer Brooks, PhD Anna Helena Furberg-Barnes, PhD

Department of Anesthesiology and Critical Care Medicine as of March 15, 2013

ATTENDINGS ASSOCIATE ATTENDINGS Amy Lu, MD David Amar, MD Kenneth H. Cubert, MD Jennifer Mascarenhas, MD Lisa R. Barr, MD Jamie A. Fortunoff, MD Eileen P. McAleer, MD Ruth A. Borchardt, MD Eric R. Kelhoffer, MD Leslie S. Ojea, MD Department of Laboratory Medicine as of March 15, 2013 Paul H. Dalecki, MD Vivek T. Malhotra, MD Alessia C. Pedoto, MD Dawn P. Desiderio, MD Louis P. Voigt, MD Kane O. Pryor, MBBS ATTENDINGS ASSOCIATE ATTENDINGS INSTRUCTOR CHAIR AND ATTENDING Mary Ellen Fischer, MD Vinay G. Puttanniah, MD Ann M. Dnistrian, PhD Renier J. Brentjens, MD, PhD Samuel I. McCash, MD Roger S. Wilson, MD Florence J. Grant, MD ASSISTANT ATTENDINGS Nina D. Raoof, MD Martin Fleisher, PhD April E. Chiu, MD Founder’s Chair Jeffrey Groeger, MD James R. Alberti, MD Elizabeth F. Rieth, MD Hans G. Lilja, MD, PhD Richard C. Meagher, PhD Neil A. Halpern, MD Vittoria Arslan-Carlon, MD Larisa Storozhenko, MD, DO Peter G. Maslak, MD Rekha Parameswaran, MD Paul M. Heerdt, MD, PhD Kara M. Barnett, MD Luis E. Tollinche, MD Eric G. Pamer, MD Anne C. Kolker, MD Sarah L. Bowman, MD Hallie Weiss, MD CHAIR AND ATTENDING Enid A. Haupt Chair in ASSISTANT ATTENDINGS Clinical Investigation Alan L. Kotin, MD Clara Broad, MD Cindy Beng-Imm Yeoh, MD Melissa S. Pessin, MD, PhD Maria E. Arcila, MD Ellinor I. B. Peerschke, PhD William L. Marx, MD Mohit Chawla, MD Ngolela Esther Babady, PhD Lilian M. Reich, MD Stephen M. Pastores, MD Sanjay Chawla, MD INSTRUCTORS Christine Gi-Yun Moung, MD Trudy Nan Small, MD Roger E. Padilla, MD Anahita Dabo-Trubelja, MD Anoushka Maria Afonso, MD Kazunori Murata, PhD Gerald A. Soff, MD Diane E. Stover, MD Amitabh Gulati, MD Joseph C. Hung, MD Christopher Y. Park, MD, PhD Yi-Wei Tang, MB, MSc, PhD Alisa C. Thorne, MD Kaye E. Hale, MD David C. Park, MD David L. Wuest, MD Robert A. Veselis, MD Robert Piljae Lee, MD Larry J. Smith, PhD DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Medical Physics as of March 15, 2013 Department of Medicine as of March 15, 2013

ATTENDINGS Doracy P. Fontenla, PhD David H. Gultekin, PhD Paul A. Glare, MBBS Craig H. Moskowitz, MD Philip Schulman, MD Kathleen N. S. Cathcart, MD Howard I. Amols, PhD Y. C. David Huang, PhD Hongbiao Carl Le, PhD Michael S. Glickman, MD Robert J. Motzer, MD Gary K. Schwartz, MD Chih-Shan Jason Chen, MD, PhD Chandra M. Burman, PhD Margie A. Hunt, MS Guang (George) Li, PhD Alfred P. Sloan Chair Patricia L. Myskowski, MD Andrew D. Seidman, MD Gabriela Chiosis, PhD John L. Humm, PhD Andrew Jackson, PhD Jingdong Li, PhD Richard D. Granstein, MD Kenneth K. Ng, MD Kent A. Sepkowitz, MD Gabriella M. D’Andrea, MD Peter Kijewski, PhD Assen S. Kirov, PhD Ruimei Ma, PhD Jeffrey S. Groeger, MD Larry Norton, MD Moshe Shike, MD Chau T. Dang, MD Jason A. Koutcher, MD, PhD Dale M. Lovelock, PhD Jung Hun Oh, PhD José Guillem, MD Norna S. Sarofim Chair in Clinical Stewart Shuman, MD, PhD Gary E. Deng, MD, PhD Oncology CHAIR AND ATTENDING Gloria C. Li, PhD Yousef Mazaheri, PhD Kyung K. Peck, PhD Allan C. Halpern, MD Simon H. Rifkind Chair Maura N. Dickler, MD Kevin Oeffinger, MD Joseph O. Deasy, PhD Thomas J. LoSasso, PhD James G. Mechalakos, PhD Charles R. Schmidtlein, PhD Neil A. Halpern, MD Nancy T. Sklarin, MD Pamela R. Drullinsky, MD Enid A. Haupt Chair Kenneth Offit, MD Gikas S. Mageras, PhD Sadek Nehmeh, PhD Jazmin Schwartz, PhD Audrey M. Hamilton, M.D Gerald A. Soff, MD Alan L. Engelberg, MD of Medical Physics Alan N. Houghton, MD Richard J. O’Reilly, MD Robert Forman Spiera, MD Jean M. St. Germain, MS Ceferino H. Obcemea, PhD Govindarajan Srimathveeravalli, PhD Claire L. Tow Chair in Pediatric Marc B. Feinstein, MD Lloyd J. Old Chair for Clinical Richard M. Steingart, MD Ellen D. Yorke, PhD Joseph A. O’Donoghue, PhD Yulin Song, PhD Investigation Oncology Research Theodore R. Fields, MD Richard Stern, MD Stephanie A. Fish, MD Marco Zaider, PhD Kristen L. Zakian, PhD Sunitha B. Thakur, PhD Clifford A. Hudis, MD Stephen A. Paget, MD Diane E. Stover, MD Maya Gambarin-Gelwan, MD Pat B. Zanzonico, PhD Neelam Tyagi, PhD David H. Ilson, MD, PhD Esperanza B. Papadopoulos, MD ASSISTANT ATTENDINGS David J. Straus, MD Venera Grasso, MD Harini Veeraraghavan, PhD Ann A. Jakubowski, MD, PhD Gavril W. Pasternak, MD, PhD ASSOCIATE ATTENDINGS Anne Burnett Tandy Chair of Steven M. Sugarman, MD Hani Hassoun, MD Ellen Ackerstaff, PhD Weijun Xiong, PhD Suresh C. Jhanwar, PhD Neurology Martin S. Tallman, MD Martee L. Hensley, MD Douglas J. Ballon, PhD Ase M. Ballangrud-Popovic, PhD Guozhen (Jenny) Yang, PhD Lewis J. Kampel, MD Stephen Pastores, MD Yi-Wei Tang, MB, MSc, PhD James J. Hsieh, MD, PhD Maria F. Chan, PhD Lawrence T. Dauer, PhD Pengpeng Zhang, PhD David Paul Kelsen, MD David G. Pfister, MD Amita Dave, PhD Cesar Della Biancia, PhD Qinghui Zhang, PhD Edward S. Gordon Chair in Maria Theodoulou, MD Katharine C. Hsu, MD, PhD Yusuf E. Erdi, DSc Paul Frisch, PhD Medical Oncology Carol S. Portlock, MD Craig B. Thompson, MD Michelle N. Johnson, MD Nancy E. Kemeny, MD Govindaswami Ragupathi, PhD R. Michael Tuttle, MD Marcia F. Kalin, MD Richard N. Kolesnick, MD Lilian M. Reich, MD, PhD Nicholas Jon Vander Els, MD Noah D. Kauff, MD Isabelle Rivière, PhD Department of Medicine as of March 15, 2013 Jason A. Koutcher, MD, PhD Stephen R. Veach, MD Mary L. Keohan, MD Mark G. Kris, MD Mark E. Robson, MD Andrew J. Vickers, PhD Jeffrey A. Knauf, PhD William and Joy Ruane Chair in DIVISION HEADS AND SENIOR ATTENDING Philip C. Caron, MD, PhD Nancy Roistacher, MD Carolyn Wasserheit, MD Jason Konner, MD Thoracic Oncology ATTENDINGS Bayard Clarkson, MD Albert R. Casazza, MD Neal Rosen, MD, PhD Sidney J. Winawer, MD Beatriz Korc-Grodzicki, MD, PhD Robert C. Kurtz, MD Enid A. Haupt Chair in Medical Paul Sherlock Chair Ephraim S. Casper, MD Enid A. Haupt Chair of Barrie R. Cassileth, PhD Oncology Lee M. Krug, MD Division of Network Therapeutic Research Diana E. Lake, MD David L. Wuest, MD Laurance S. Rockefeller Chair in Mario E. Lacouture, MD Medicine Services Integrative Medicine Steven M. Larson, MD Paul J. Sabbatini, MD Han Xiao, MD Donna and Benjamin M. Rosen Chair Sheron Latcha, MD Eric G. Pamer, MD ATTENDINGS Hugo Castro-Malaspina, MD Michel Sadelain, MD, PhD Anas Younes, MD Division of General Medicine; in Radiology Stephen and Barbara Friedman Chair Ross Levine, MD Carol Aghajanian, MD Raju S.K. Chaganti, PhD James W. Young, MD CHAIR AND ATTENDING Enid A. Haupt Chair Stuart M. Lichtman, MD Leonard B. Saltz, MD Jennifer E. Liu, MD Scott A. Armstrong, MD, PhD William E. Snee Chair Ann G. Zauber, PhD George J. Bosl, MD in Clinical Investigation Hans G. Lilja, MD Jean T. Santamauro, MD C. Ronald MacKenzie, MD The Patrick M. Byrne Chair in Grayer Family Chair Paul B. Chapman, MD Andrew D. Zelenetz, MD, PhD David R. Spriggs, MD Michael D. Lockshin, MD Charles L. Sawyers, MD Vivek Malhotra, MD, MPH Clinical Oncology Division of Solid Tumor Oncology; Peter Bach, MD Dan Douer, MD Steven K. Magid, MD Marie-Josée and Henry R. Kravis Chair Simon Mantha, MD Winthrop Rockefeller Chair in Dean F. Bajorin, MD James A. Fagin, MD in Human Oncology and Pathogenesis; ASSOCIATE ATTENDINGS Medical Oncology Joseph A. Markenson, MD Ashfaq A. Marghoob, MD José Baselga, MD, PhD John J. Fiore, MD Howard Hughes Medical Institute Ghassan K. Abou-Alfa, MD Marcel R. M. van den Brink, Arnold J. Markowitz, MD Investigator Franklin Marsh, MD Michael S. Baum, MD Carlos D. Flombaum, MD David R. Artz, MD MD, PhD Paul A. Marks, MD Michael R. McDevitt, PhD Ellin Berman, MD Kathleen M. Foley, MD David A. Scheinberg, MD, PhD Juliet N. Barker, MBBS Division of Hematologic Oncology; The Society of Memorial Sloan- Steven C. Martin, MD Vincent Astor Chair Richard C. Meagher, PhD William S. Breitbart, MD Anne R. Bass, MD Alan N. Houghton Chair Kettering Cancer Center Chair Howard I. Scher, MD Michael J. Morris, MD Murray F. Brennan, MD Peter G. Maslak, MD D. Wayne Calloway Chair in Urologic Renier J. Brentjens, MD, PhD Benno C. Schmidt Chair in Francesca M. Gany, MD Nancy E. Mills, MD Mary E. Moynahan, MD Oncology Jacqueline F. Bromberg, MD, PhD Clinical Oncology Hans Gerdes, MD Malcolm A. S. Moore, DPhil Kishwer S. Nehal, MD William J. Schneider, MD Alan C. Carver, MD Arthur E. Brown, MD Teresa Ann Gilewski, MD Enid A. Haupt Chair of Cell Biology Deena J. Nelson, MD Sergio A. Giralt, MD DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Medicine as of March 15, 2013 Department of Medicine as of March 15, 2013

Ariela Noy, MD Sree Bhavani Chalasani, MBBS Mrinal M. Gounder, MD Anna R. Marcelli, MD Neil H. Segal, MD, PhD Roma Tickoo, MD, MPH Kenneth Ho-Ming Yu, MD Oscar Boutros Lahoud, MD Eileen M. O’Reilly, MB, BCh, BAO Sarat Chandarlapaty, MD, PhD Polly D. Gregor, PhD Matthew J. Matasar, MD Pari M. Shah, MD Emily S. Tonorezos, MD, MPH Marjorie G. Zauderer, MD James C. Lee, MD Genovefa A. Papanicolaou, MD Mohit Chawla, MD Yvona Griffo, MD Eileen P. McAleer, MD Eric J. Sherman, MD Tiffany A. Traina, MD Alison Marie Mainardi, MD Rekha Parameswaran, MBBS Sanjay Chawla, MD Rachel N. Grisham, MD Heather L. McArthur, MD Marisa Siebel, MD Tiffany Troso-Sandoval, MD INSTRUCTORS Anjali A. Nigalaye, MD Milind Rajadhyaksha, PhD Carol L. Chen, MD Ayca Gucalp, MD Peter A. Mead, MD Stephanie Smith-Marrone, MD Lisa C. Vasanth, MD Vivek K. Arora, MD, PhD Ranish Gautam Patel, MD Naiyer A. Rizvi, MD Yu Chen, MD, PhD Rebecca D. S. Guest, MD Robin B. Mendelsohn, MD Philip S. Spencer, MD Adrienne Vincenzino, MD Kathleen R. Atlas, MD Pallavi Patri, MD Jonathan E. Rosenberg, MD Ping Chi, MD, PhD Shellie Gumbs, MD Charis Fan-Hui Meng, MD Stacy M. Stabler, MD, PhD Martin H. Voss, MD Samarth Beri, MD Tracy Ann Proverbs-Singh, MD Mona Sabra, MD Geoffrey Beene Junior Faculty Chair Kaye E. Hale, MD Taha Merghoub, PhD Zsofia K. Stadler, MD George K. Wang, MD, PhD Maria I. Carlo, MD Yael Miriam Raymon, MD Lisa R. Sammaritano, MD David J. Chung, MD, PhD Paul A. Hamlin, MD Shanu Modi, MD Sung Wu Sun, MD Steven Q. Wang, MD Judy Dong, DO Wael C. Saleh, MB, ChB Mark A. Schattner, MD Helen H. Chung, MD Alan M. Hanash, MD, PhD Patricia and James Cayne Chair for William D. Tap, MD Kathleen M. Wesa, MD Juan Pablo Galvez, MD Nicole Marie Tyer, MD Junior Faculty Sergio Schwartzman, MD Elizabeth A. Comen, MD Alan Loh Ho, MD, PhD Ying Taur, MD Richard M. White, MD, PhD Nicole C. Hadi, MD Ana M. Molina, MD Susan K. Seo, MD Sandra P. D’Angelo, MD Steven M. Horwitz, MD Sohail F. Tavazoie, MD, PhD Hendricks H. Whitman, III, MD Stephan Heo, MD Natalie Moryl, MD Monika Shah, MD Daniel C. Danila, MD David M. Hyman, MD William P. Tew, MD Rona D. Yaeger, MD Gopakumar V. Iyer, MD Alison J. Moskowitz, MD Susan F. Slovin, MD, PhD Marco L. Davila, MD, PhD Yelena Y. Janjigian, MD Muthukumar Thangamani, MBBS Arthur M. F. Yee, MD, PhD Nivedita N. Kumar, MBBS Tanya M. Nikolova, MD David B. Solit, MD Jennifer L. DeFazio, MD Robert Jenq, MD Dharmarao Thapi, PhD Joseph P. Yoe, MBBS Stephen J. Kuperberg, MD Roisin E. O’Cearbhaill, MB, Robert F. Spiera, MD Liang Deng, MD, PhD Erik K. Johnson, MD BCh, BAO Richard Stern, MD Avni M. Desai, MD Anna Kaltsas, MD Susan A. Oliveria, ScD, MPH Gina M. Villani, MD, MPH Madhuri Devabhaktuni, MBBS Mini Kamboj, MBBS as of March 15, 2013 Barbara O’Sullivan, MD Department of Neurology Louis P. Voigt, MD Lisa C. Diamond, MD, MHS, MPH Rana Kaplan, MD Paul K. Paik, MD Jonathan W. Weinsaft, MD Mark A. Dickson, MD Amsale Ketema, MD ATTENDINGS ASSOCIATE ATTENDINGS Babak Navi, MD Maria Lia Palomba, MD Howard Weinstein, MD Stephen J. Di Martino, MD, PhD Kyriakos A. Kirou, MD, DSc Ronald G. Blasberg, MD Alan C. Carver, MD Antonio M. P. Omuro, MD Jae Hong Park, MD Jedd D. Wolchok, MD, PhD Barbara C. Egan, MD Robert J. Klein, PhD Robert B. Darnell, MD, PhD Xi Chen, MD, PhD Elena Pentsova, MD Edward J. Parrish, MD Andrew S. Epstein, MD Virginia M. Klimek, MD Kathleen M. Foley, MD Denise D. Correa, PhD Lisa M. Ruppert, MD Tina M. Passalaris, MD ASSISTANT ATTENDINGS Doruk Erkan, MD Adam D. Klotz, MD The Society of Memorial Sloan- Yasmin Khakoo, MD Sonia K. Sandhu, DO Miguel-Angel Perales, MD Kettering Cancer Center Chair Omar I. Abdel-Wahab, MD Azeez Farooki, MD Guenther Koehne, MD, PhD Ingo K. Mellinghoff, MD Jonas M. Sokolof, DO Maria C. Pietanza, MD Paul A. Glare, MBBS Juliet B. Aizer, MD Julie Fasano, MD Douglas Koo, MD, MPH CHAIR AND ATTENDING Craig P. Nolan, MD Roma Tickoo, MD, MPH Doris Ponce, MD Eric Holland, MD, PhD Arlyn Apollo, MD Darren R. Feldman, MD Geoffrey Y. Ku, MD Lisa M. DeAngelis, MD Ying-Xian Pan, PhD Efstathia Tzatha, MD Christine Querfeld, MD Lillian Rojtman Berkman Chair Emily Tow Jackson Chair Abraham Aragones, MD, MS Monica N. Fornier, MD Chhavi Bansal Kumar, MD in Oncology Michael D. Stubblefield, MD Kaleb H. Yohay, MD Elizabeth A. Quigley, MD in Honor of Jerome B. Posner Dalit Ashany, MD Matthew G. Fury, MD, PhD Heather J. Landau, MD Dragos Rancea, MD Gavril W. Pasternak, MD, PhD Shrujal Baxi, MD Devika Gajria, MD Erica H. Lee, MD Anne Burnett Tandy Chair ASSISTANT ATTENDINGS INSTRUCTORS Raajit K. Rampal, MD, PhD Katherine M. Bell-McGuinn, John F. Gerecitano, MD, PhD Robert P. Lee, MD of Neurology Edward K. Avila, DO Milan Chheda, MD Nina D. Raoof, MD MD, PhD Alexander Geyer, MD Dawn Lemanne, MD Jerome B. Posner, MD Christian M. Custodio, MD Kevin C. De Braganca, MD Dana E. Rathkopf, MD American Cancer Society Clinical Stefan Berger, MD Monica Girotra, MD Nikoletta Lendvai, MD, PhD Marc J. Dinkin, MD Christian Grommes, MD Diane L. Reidy, MD Research Professor; George C. Cotzias Jessica R. Berman, MD Ilya G. Glezerman, MD Jennifer C. Leng, MD, MPH Chair of Neuro-Oncology Igor T. Gavrilovic, MD Gregory J. Riely, MD, PhD Victoria S. Blinder, MD Jenna Goldberg, MD Michelle K. Logozzo, MD Neal Rosen, MD, PhD Yvona Griffo, MD Marina Rozenberg, MD Laura Boucai, MD Zoe Goldberg, MD Alexander M. Lesokhin, MD Enid A. Haupt Chair in Katarzyna Ibanez, MD Linda A. Russell, MD Medical Oncology Michelle S. Boyar, MD Shari Goldfarb, MD Maeve A. Lowery, MB, BCh, BAO Thomas Kaley, MD Mabel M. Ryder, MD Jonathan D. Victor, MD, PhD Vivian P. Bykerk, MD Stephanie M. Goodman, DO Emmy Ludwig, MD Susruta Majumdar, PhD Cori Salvit, MD Richard D. Carvajal, MD Susan M. Goodman, MD Vicky Makker, MD Natalie Moryl, MD Nelson F. Sanchez, MD Andrea Cercek Hanjis, MD Tabitha N. Goring, MD Lisa A. Mandl, MD Craig S. Sauter, MD Jamie E. Chaft, MD Mila Gorsky, MD Debra Mangino, DO Wendy L. Schaffer, MD, PhD DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Neurosurgery as of March 15, 2013 Department of Pediatrics as of March 15, 2013

ATTENDINGS ASSOCIATE ATTENDINGS ASSISTANT ATTENDINGS ATTENDINGS Yasmin Khakoo, MD Julia A. Kearney, MD Mark H. Bilsky, MD Cameron W. Brennan, MD Jeffrey P. Greenfield, MD, PhD David H. Abramson, MD Kim Kramer, MD David C. Lyden, MD, PhD Eric C. Holland, MD, PhD Michael Kaplitt, MD, PhD Ilya Laufer, MD Scott A. Armstrong, MD, PhD Richard C. Meagher, PhD Ajay Mirani, MD Emily Tow Jackson Chair Mark M. Souweidane, MD Grayer Family Chair Shakeel Modak, MD Steven Pon, MD in Oncology Viviane S. Tabar, MD Farid Boulad, MD Joshua P. Needleman, MD Christine A. Pratilas, MD Samuel H. Selesnick, MD Nai-Kong V. Cheung, MD, PhD Andromachi Scaradavou, MD Susan E. Prockop, MD Philip E. Stieg, MD, PhD Enid A. Haupt Chair in Pediatric CHAIR AND ATTENDING CHAIR AND ATTENDING Mark Souweidane, MD Stephen S. Roberts, MD Lorenz P. Studer, MD Oncology Philip H. Gutin, MD Richard J. O’Reilly, MD Tanya M. Trippett, MD Peter M. C. Savard, MD Fred Lebow Chair in Claire L. Tow Chair in Patricia J. Giardina, MD Maria G. Vogiatzi, MD Neerav N. Shukla, MD Neuro-Oncology Pediatric Oncology Research Nancy A. Kernan, MD Stefan Worgall, MD, PhD Leonard G. Steinberg, MD Brian H. Kushner, MD Anne E. Stone, MD Michael P. LaQuaglia, MD ASSISTANT ATTENDINGS Chani Traube, MD Paul A. Meyers, MD Seena S. Abraham, MBBS Kaleb H. Yohay, MD Kevin C. Oeffinger, MD Department of Pathology as of March 15, 2013 Zoltan Antal, MD Johannes L. Zakrzewski, MD Michel Sadelain, MD, PhD Abraham Bartell, MD ATTENDINGS ASSOCIATE ATTENDINGS Deborah F. DeLair, MD Charles A. Sklar, MD Naomi B. Bishop, MD INSTRUCTORS Trudy Nan Small, MD Cristina Antonescu, MD Emily Cheng, MD, PhD Snjezana Dogan, MD Sheila J. Carroll, MD Ellen M. Basu, MD, PhD Laurel J. Steinherz, MD Edi Brogi, MD, PhD April Chiu, MD Marcia Edelweiss, MD Alexander Ja-Ho Chou, MD Kevin J. Curran, MD Peter G. Steinherz, MD Klaus J. Busam, MD Marija Drobnjak, MD Samson W. Fine, MD Nana E. Coleman, MD Kevin C. De Braganca, MD Leonard H. Wexler, MD Ronald A. Ghossein, MD Dilip D. Giri, MBBS Anuradha Gopalan, MBBS Jeffrey Dayton, MD Danielle Novetsky Friedman, MD Meera R. Hameed, MBBS Cyrus V. Hedvat, MD, PhD Travis J. Hollmann, MD, PhD Ekaterina Doubrovina, MD, PhD Rachel Kobos, MD ASSOCIATE ATTENDINGS CHAIR AND ATTENDING Suresh C. Jhanwar, PhD André L. Moreira, MD, PhD Jason T. Huse, MD, PhD Jennifer S. Ford, PhD Heather Magnan, MD James B. Bussel, MD David S. Klimstra, MD Marc Ladanyi, MD Lee K. Tan, MD Nora Katabi, MD Stephen W. Gilheeney, MD Jessica Lynn Perniciaro, MD James Ewing Chair of Pathology William J. Ruane Chair in Laura H. Tang, MD, PhD Melissa Murray, DO Irene Y. Cheung, ScD Molecular Oncology Jeffrey P. Greenfield, MD, PhD Grace J. Pinto Britton, MD Liying Zhang, MD, PhD Christopher Y. Park, MD, PhD Ira J. Dunkel, MD Oscar Lin, MD Aisha N. Hasan, MBBS Thomas M. Renaud, MD David C. Park, MD Patrick A. Flynn, MD Khedoudja Nafa, PhD Joy D. Howell, MD Edward Shlasko, MD, MBA ASSISTANT ATTENDINGS Kay J. Park, MD Bruce M. Greenwald, MD Victor E. Reuter, MD Deyin Doreen Hsing, MD Cindy Ling Wong, MD Narasimhan Agaram, MBBS Melissa P. Pulitzer, MD Jeffrey Kern, MD Marc K. Rosenblum, MD Founder’s Chair Hikmat A. Al-Ahmadie, MD Natasha Rekhtman, MD, PhD Maria E. Arcila, MD Carlie S. Sigel, MD Jinru Shia, MD Olca Basturk, MD Efsevia Vakiani, MD, PhD Robert A. Soslow, MD Michael F. Berger, PhD Lu Wang, MD, PhD Julie Teruya-Feldstein, MD Laetitia A. Borsu-Valente, PhD Britta Weigelt, PhD Satish K. Tickoo, MD Yingbei Chen, MD, PhD Yong Hannah Wen, MD, PhD William D. Travis, MD Donavan Cheng, PhD Christina E. Vallejo, MD Sarah Chiang, MD Maureen F. Zakowski, MD Adriana Dionigi Corben, MD DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Psychiatry and Behavioral Sciences as of March 15, 2013 Department of Radiology as of March 15, 2013

ATTENDINGS Denise D. Correa, PhD Jennifer C. Leng, MD ATTENDINGS ASSOCIATE ATTENDINGS Sandra Brennan, MB, BCh, BAO Timothy A. Ahles, PhD Jennifer L. Hay, PhD Wendy G. Lichtenthal, PhD Andrea F. Abramson, MD Linda R. Aboody, MD Sean D. Carlin, PhD Philip A. Bialer, MD Tomer T. Levin, MBBS Christian J. Nelson, PhD Sara J. Abramson, MD Oguz Akin, MD Joshua L. Chaim, DO Katherine N. DuHamel, PhD Yuelin Li, PhD James C. Root, PhD Ariadne M. Bach, MD William Alago, Jr., MD Donna D. D’Alessio, MD Francesca M. Gany, MD Elizabeth L. Ryan, PhD Michael S. Baum, MD Douglas J. Ballon, PhD Lawrence Dauer, PhD Teresa A. Gilewski, MD ASSISTANT ATTENDINGS Talia I. Zaider, PhD Ronald G. Blasberg, MD Michelle S. Bradbury, MD, PhD Kinh Gian Do, MD, PhD ACTING CHAIR AND ATTENDING Jimmie C. Holland, MD Abraham Aragones, MD CHAIR AND ATTENDING Mark J. Bluth, MD Lynn A. Brody, MD Mark Phillip S. Dunphy, DO William S. Breitbart, MD Wayne E. Chapman Chair of Yesne Alici-Evcimen, MD INSTRUCTORS Hedvig Hricak, MD, PhD Karen T. Brown, MD Betty A. Caravella, MD Joseph P. Erinjeri, MD, PhD Psychiatric Oncology Carroll and Milton Petrie Chair Thomas M. Atkinson, PhD Matthew N. Doolittle, MD James F. Caravelli, MD Anne M. Covey, MD Stephen E. Fleming, Jr., MD Mary Jane Massie, MD Smita Banerjee, PhD Richard Garrett Key, MD Jorge A. Carrasquillo, MD Amita Dave, PhD Josef J. Fox, MD Jamie S. Ostroff, PhD Abraham S. Bartell, MD Melissa L. Ozga, DO Christopher E. Comstock, MD Otilia-Liana Dumitrescu, MD James L. Fuqua III, MD Andrew J. Roth, MD, Jack E. Burkhalter, PhD Ziomara D. Rocha-Cadman, MD D. David Dershaw, MD Jeremy C. Durack, MD Athanasios P. Glekas, PhD Lisa C. Diamond, MD, MPH Yuman Fong, MD Kimberly N. Feigin, MD Ravinder K. Grewal, MD ASSOCIATE ATTENDINGS Jennifer S. Ford, PhD George I. Getrajdman, MD Arthur A. Fruauff, MD Jan Grimm, MD, PhD Carma L. Bylund, PhD Julia A. Kearney, MD Michelle S. Ginsberg, MD Scott R. Gerst, MD David H. Gultekin, PhD Jeanne Carter, PhD Marc J. Gollub, MD Linda A. Heier, MD Sofia S. Haque, MD Robert T. Heelan, MD Tunç A. Iyriboz, MD Vaios Hatzoglou, MD Andrei I. Holodny, MD Stefanie S. Jacobs, MD Mary C. Hughes, MD John L. Humm, PhD Maxine S. Jochelson, MD Sinchun Hwang, MD Peter K. Kijewski, PhD Jennifer B. Kaplan, MD Seth S. Katz, MD, PhD Department of Radiation Oncology as of March 15, 2013 Jason A. Koutcher, MD, PhD Sasan Karimi, MD Moritz F. Kircher, MD George Krol, MD Karen B. Karlson, MD Yuliya Lakhman, MD ATTENDINGS ASSOCIATE ATTENDINGS ASSISTANT ATTEDINGS Steven M. Larson, MD Delia M. Keating, MD Jonathan Landa, DO David H. Abramson, MD Timothy Chan, MD, PhD Christopher A. Barker, MD Donna and Benjamin M. Robert A. Lefkowitz, MD Duan Li, MD Rosen Chair in Radiology Kaled M. Alektiar, MD Daphna Y. Gelblum, MD Kathryn F. Beal, MD Eric Lis, MD John K. Lyo, MD Carol H. Lee, MD Adriana Haimovitz-Friedman, PhD Karyn A. Goodman, MD Karen Borofsky, MD Yousef Mazaheri, PhD Weining Ma, MD Jason S. Lewis, PhD Gloria C. Li, PhD Nancy Lee, MD Pinaki R. Dutta, MD, PhD Michael R. McDevitt, PhD Majid Maybody, MD Laura Liberman, MD Beryl McCormick, MD Borys R. Mychalczak, MD Richard M. Gewanter, MD Sadek Nehmeh, PhD Svetlana Mironov, MD Elizabeth A. Morris, MD CHAIR AND ATTENDING Karen D. Schupak, MD Yoshiya Yamada, MD Alice Yoosun Ho, MD Neeta Pandit-Taskar, MBBS Joseph R. Osborne, MD, PhD David M. Panicek, MD Simon N. Powell, MD, PhD Suzanne L. Wolden, MD Marisa A. Kollmeier, MD Harpreet K. Pannu, MD Kyung Peck, PhD Enid A. Haupt Chair in Anita P. Friedman Price, MD Joachim Yahalom, MD James E. Lee, MD Naga Vara Kishore Pillarsetty, PhD Vladimir Ponomarev, MD, PhD Radiation Oncology Evis Sala, MD, PhD Michael J. Zelefsky, MD Boris Mueller, MD Jurgen Rademaker, MD Thomas Reiner, PhD Heiko Schöder, MD Preeti K. Parhar, MD Debra M. Sarasohn, MD Elmer B. Santos, MD, PhD Stephen B. Solomon, MD William R. Polkinghorn, MD Marc Z. Simmons, MD Robert H. Siegelbaum, MD Hilda E. Stambuk, MD Shyam S. D. Rao, MD, PhD Constantinos T. Sofocleous, Govindarajan Srimathveeravalli, PhD Richard M. Steingart, MD Andreas Rimner, MD MD, PhD Janice S. Sung, MD H. William Strauss, MD Helen L. Sidebotham, MD Raymond H. Thornton, MD Sunitha Bai Thakur, PhD Jerrold B. Teitcher, MD Abraham Jing-Ching Wu, MD Barbara Wajsbrot-Kandel, MD Gary A. Ulaner, MD, PhD Jean M. Torrisi, MD Melissa R. Remis Zinovoy, MD Jonathan W. Weinsaft, MD Hebert A. Vargas Alvarez, MD Wolfgang A. Weber, MD Corinne B. Winston, MD Darren R. Veach, PhD Pat Zanzonio, PhD Kristen L. Zakian, PhD Robert J. Young, MD Robert D. Zimmerman, MD

ASSISTANT ATTENDINGS INSTRUCTOR Allison S. Aguado, MD Barbara Raphael, MD Miriam Benezra, PhD DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Surgery as of March 15, 2013 Department of Surgery as of March 15, 2013

DIVISION HEAD AND José G. Guillem, MD ASSOCIATE ATTENDINGS ASSISTANT ATTENDINGS Allan D. Greenberg, DMD, PhD Colleen M. McCarthy, MD INSTRUCTORS ATTENDING John H. Healey, MD Peter J. Allen, MD Prasad S. Adusumilli, MBBS Jerry L. Halpern, DDS Luc G. T. Morris, MD Stephen J. Kuperberg, MD Ronald P. DeMatteo, MD Stephen McDermott Chair in Surgery Edward A. Athanasian, MD Charlotte E. Ariyan, MD, PhD James Huang, MD Garrett M. Nash, MD Wael Custandi Saleh, MBChB Division of General Surgical Oncology; Alexandra S. Heerdt, MD Oheneba Boachie-Adjei, MD Brett S. Carver, MD Elizabeth L. Jewell, MD George Plitas, MD Edward Shlasko, MBA, MD Leslie H. Blumgart Chair in Surgery Harry W. Herr, MD Jay O. Boyle, MD Mohit Chawla, MD John Karwowski, MD Jaspreet S. Sandhu, MD William J. Hoskins, MD ATTENDINGS Mary S. Brady, MD Jonathan A. Coleman, MD T. Peter Kingham, MD Inderpal Singh Sarkaria, MD CHAIR AND ATTENDING Joseph M. Huryn, DDS David H. Abramson, MD Carol L. Brown, MD Aimee M. Crago, MD, PhD John P. Lyden, MD Nitsana A. Spigland, MD Peter T. Scardino, MD William R. Jarnagin, MD Deborah M. Capko, MD Marc J Dinkin, MD Charles A. Mack III, MD Steven J. Tunick, DMD David H. Koch Chair Nadeem R. Abu-Rustum, MD Enid A. Haupt Chair in Surgery Jeanne Carter, PhD David J. Finley, MD Debra A. Mangion, DO Zhaoshi Zeng, MD, MPH Manjit S. Bains, MD Maureen Killackey, MD Michael D’Angelica, MD Ian Ganly, MB, ChB, PhD Brian P. Marr, MD Neil H. Bander, MD Michael P. LaQuaglia, MD Richard R. Barakat, MD Joseph H. Burchenal Chair in Cherry L. Estilo, DMD Leonard N. Girardi, MD Evan Matros, MD Ronald O. Perelman Chair in Pediatrics Ginger J. Gardner, MD Gynecologic Surgery Hans G. Lilja, MD Mary L. Gemignani, MD Leslie H. Blumgart, MD Monica Morrow, MD Henry G. Godfrey, MD Bernard H. Bochner, MD Anne Burnett Windfohr Chair of Deborah J. Goldfrank, MD Human Oncology and Pathogenesis Program as of March 15, 2013 Patrick J. Boland, MD Clinical Oncology Murk-Hein Heinemann, MD Murray F. Brennan, MD John P. Mulhall, MB, BCh, BAO Noah Kauff, MD ATTENDINGS ASSISTANT ATTENDINGS INSTRUCTORS Benno C. Schmidt Chair in Clinical Raul O. Parra, MD Oncology Tari King, MD Scott A. Armstrong, MD, PhD Omar I. Abdel-Wahab, MD Anruddha J. Deshpande, PhD Philip B. Paty, MD Jeanne A. Petrek Junior Faculty Grayer Family Chair Mercedes Castiel, MD Michael F. Berger, MD Nan Zhu, PhD Valerie W. Rusch, MD Chair José Baselga, MD, PhD Dennis S. Chi, MD Miner Family Chair in Intrathoracic Sarat Chandarlapaty, MD, PhD Vincent Laudone, MD James A. Fagin, MD Hiram S. Cody III, MD Cancers Yu Chen, MD, PhD Mario M. Leitao, Jr., MD Marc Ladanyi, MD Daniel G. Coit, MD Paul Russo, MD Ping Chi, MD, PhD Douglas A. Levine, MD Geoffrey Beene Junior Peter G. Cordeiro, MD Virgilio Sacchini, MD CHAIR AND ATTENDING Babak J. Mehrara, MD Faculty Chair Guido Dalbagni, MD Lisa M. Sclafani, MD Charles L. Sawyers, MD ASSOCIATE ATTENDINGS Carol D. Morris, MD Marie-Josée and Henry R. Kravis Chair Cameron Brennan, MD Andrei V. Krivtsov, PhD Joseph J. Disa, MD Jatin P. Shah, MD in Human Oncology and Pathogenesis; Elliot W. Strong Chair in Head and Oliver J. Muensterer, MD, PhD Timothy A. Chan, MD, PhD Christopher Y. Park, MD, PhD S. Machele Donat, MD Howard Hughes Medical Institute Neck Oncology Snehal G. Patel, MBBS Frederick R. Adler, Chair for Robert J. Downey, MD Investigator Ashok R. Shaha, MD Andrea L. Pusic, MD Junior Faculty James A. Eastham, MD Jatin P. Shah Chair in Head and Neck Nabil Rizk, MD Emily H. Cheng, MD, PhD Florence and Theodore Baumritter/ Surgery and Oncology Enid Ancell Chair of Urologic Glenn L. Schattman, MD Adriana Heguy, PhD Oncology Joel Sheinfeld, MD James J. Hsieh, MD, PhD William G. Cahan Chair in Surgery Darren B. Schneider, MD Mahmoud El-Tamer, MD Yukio Sonoda, MD Ross L. Levine, MD Samuel Singer, MD Yuman Fong, MD Vivian E. Mack Strong, MD Ingo K. Mellinghoff, MD Murray F. Brennan Chair in Surgery Bhuvanesh Singh, MD, PhD Larissa K. F. Temple, MD David Solit, MD Pramod C. Sogani, MD Harold P. Freeman, MD Karim A. Touijer, MD Diane E. Stover, MD Julio Garcia-Aguilar, MD, PhD Martin R. Weiser, MD Stuart H. Q. Quan Chair in Kimberly J. Van Zee, MD Colorectal Surgery Richard J. Wong, MD Sam S. Yoon, MD DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Nursing as of March 15, 2013 Department of Nursing as of March 15, 2013

DIRECTORS Altagracia I. Mota, RN CLINICAL NURSE SPECIALISTS NURSE PRACTITIONERS/NP Maria Elena C. Cantos, ANP, ACNP, Anthony De La Cruz, CRNP, RN Maureen Guiney, NP, RN Carlton G. Brown, PhD, RN, AOCN Maryellen O’Sullivan, RN Jean Adelhardt, RN COORDINATORS RN Meghan Decker, NP, RN Michelle Hall, ANP, RN Kevin P. Browne, RN Diane Paolilli, RN Roberta H. Baron, RN Megan P. Abate, ANP, RN Maryann Carousso, FNP, AOCNP, Joanne Delaleu, NP, RN Joshua Halpert, NP, RN Michelle Burke, RN Elizabeth S. Rodriguez, DNP, RN Christopher Brooks, RN Lynn Adams, ANP, RN RN Susan Derby, GNP, RN Elizabeth F. Halton, ANP, RN MaryAnn Connor, RN Corey Russell, MSN, OCN Kathleen Choo, RN Melanie Albano, ANP, RN Erin K. Carr, FNP, RN Amy Rose Devigne, FNP, RN Joan M. Hartnett, ANP, RN Mary E. Dowling, RN Jane A. Sallustro, RN Suzanne Costello, RN Rose Ali, ANP, RN Roseann Caruso, NP, RN Kleoniki Diamantis, FNP, RN Kelly Haviland, NP, RN CHIEF NURSING OFFICER Dennis Graham, DNSc, ANP, RN Robert Schley, RN Maureen F. Cunningham, RN Karen V. Allison, CPNP, RN Anne Regan Casson, CPNP, RN Deborah Diotallevi, CPNP, RN Courtney E. Hennelly, ANP, RN Elizabeth Nelkin McCormick, Josephine Nappi, RN Anna M. Schloms, RN Mary Elizabeth Davis, RN Lorraine E. Anderson, ANP, RN Naomi Cazeau, NP RN Maria Donzelli, CPNP, RN Alison Hergianto, CRNP, RN MSN, RN R. David Rice, PhD, AOCNP, RN Lenore Smykowski, RN Kristyn DiFortuna, RN Latasha Anderson-Dunkley, ANP, RN Jessica Cerulli, NP, RN Karen Dougherty, ANP, RN Evlyn L. Hinds, FNP, RN Enid A. Haupt Chair of Nursing Rori Salvaggio, MSN , RN Patricia Spellman, RN Nkechi Fearon, RN Ramadevi Arcot, ANP, RN Mei Ling Chan, ANP, RN Karen Drucker, ANP, RN Ashley Hole, FNP, RN Donna Schick, RN Lystra M. Swift, RN Erica A. Fischer-Cartlidge, RN Nadine Auguste, ACNP, RN Ewa Chauvin, ANP, RN Lauren Drysdale, ANP, RN Karen E. Holritz, ANP, RN Blanca M. Vasquez-Clarfield, RN Elizabeth R. Grahn, RN Jennifer Aviado-Langer, FNP, RN Kimberly Chow, NP, RN Jane Duffy-Weisser, ANP, RN Mi Young Hong, NP, RN NURSE LEADERS, MANAGERS, Keri Jean Wagner, RN Cathyann M. Hanson-Heath, RN Christina Baldwin, NP, RN Cynthia Ciaschi, AOCNP, RN Megan Dunne, ANP, RN Aletha R. Huckins, FNP, RN CLINICAL COORDINATORS Marianne Wallace, RN Catherine Hydzik, RN Cheryl D. Barnes, FNP, RN Laura Ciavolino, ANP, RN Christina Durney, CPNP, RN Lauren Hughes, NP, RN Abigail Baldwin, RN Maribeth Woodridge-King, RN Sandra E. James, RN Elizabeth Barry, NP, RN Keith A. Clement, ANP, RN Nancy E. Edmonds, ANP, RN Solange D. Inglis, ANP, RN Patricia Brosnan, RN Noelene A. Johnson, RN Melissa Barzola, ACNP, RN Gloria Coffey, ANP, RN Carlene Edwards, FNP, RN Christine Scura Iovino, FNP, RN Jacquelyn Burns, RN CLINICAL NURSE SUPERVISORS Joyce E. Kane, RN Desiree Bascombe, ANP, RN Kristen Cognetti, NP, RN Glenda Espinosa, ANP, RN Shani Irby, NP, RN Carole M. Cass, RN Nancy M. Borzain, RN Nancy Karo, RN Raffi Artine Bashlian, ANP, RN Abigail Cohen, NP, RN Catherine Ann Featherstone, FNP, RN Lorraine Jackson, ACNP, RN Kristin Cawley, RN Marie E. Cox, RN Joanne F. Kelvin, RN Melissa Bassis, ACNP, RN Nancy Collado, ANP, RN Zulay E. Fernandez, ANP, RN Mindy Jaffe, CPNP, RN Stacie Corcoran, RN Barbara K. Hutton, RN Janine Kennedy, RN Rana Bazzi, ACNP, RN Mercedes M. Condy, CRNP, RN Christine Ferrari, ANP, RN Laura A. James, ANP, RN Susan L. Dosil-Loiacono, RN Christine E. Lantier, RN Christina Kiss, RN Kimberly A. Berry, ANP, RN Erin Ann Conlon, FNP, RN Cheryl M. Fischer, CPNP, RN Jeanine Jerro-Doody, ANP, RN Mary M. Eagan, RN Kathleen Maher, RN Robina Kitzler, RN Anna Bodyziak, NP, RN Lenny Coraci, ANP, RN Cristy B. Fitzpatrick, ANP, RN Latisha A. Jones, ANP, RN Susan Filshie, RN Barbara Murphy, RN Rebecca Kolenik, RN Margaret H. Boelke, FNP, RN Rosemarie Corless, CPNP, RN Deborah A. Fleischer, ACNP, RN Christine Kasper, PNP, RN Jeanine Gordon, RN Esther M. Ruiz, RN Beth Dee Licht, RN Beth Boseski, CRNP, RN Zana Correa, ANP, RN Idania Flete-Olmeda, ANP, RN Stacey L. Kaufman, ANP, RN Judy M. Graham, RN Vashti Livingston, RN Christine Bray, NP, RN Marissa Corti, ANP, RN Jennifer A. Flood, ANP, RN Stefanie Keating, NP, RN Barbara G. Hennessey, RN NURSE EDUCATORS Diane M. Llerandi, RN Laurie Brusco, ANP, RN Alison Costalos, ACNP, RN Karen A. Flynn, ACNP, RN Sheila Keaveney, ANP, RN Nancy G. Houlihan, RN Kristy Dunleavy, RN Nora A. Love, RN Jamila N. Brutus, NP, RN Margaret Courtney, AOCNP, RN Anna Ford, NP, RN Kathleen J. Keenan, ANP, RN Matthew Kennedy, RN Wendella Facey, RN Nancy McEntee, RN Tara Buchholz, ACNP, RN Joanne Cregg, ANP, RN Christine Freise, NP, RN Elizabeth Kelliher, ANP, GNP, RN Stephanie Kennedy, RN Lisa Kennedy, RN Linda Muller, RN Bernice E. Burford, ANP, RN Catherine C. Cruz, ANP, RN Jamie Fritts, NP, RN Paulette M. Kelly, FNP, RN Michele Kranz, RN Joan McKerrow, RN Maureen G. O’Brien, RN Regina Byrne, CRNP, RN Bernadette M. Cuello, ANP, RN Erin Fusco, FNP, RN Sheila A. Kenny, ANP, RN Catherine T. Licitra, RN Jaime Louise McNally, RN Wayne Alec Quashie, RN Maura E. Byrnes-Casey, CPNP, RN Laryn M. Cullen, ANP, RN Patricia Gabriel, ANP, RN Denise M. Kessel, ANP, RN Sulin Low, RN Marjorie E. Mosley, RN Natasha Ramrup, RN Maureen Caban, ANP, RN Rhonda D’Agostino, ACNP, RN Ruth Gargan-Klinger, ANP, RN Kathleen Kilroy, ANP, RN Annmarie Mazzella-Ebstein, RN Annette V. Pineiro, RN Piera Robson, RN Jennifer M. Cagney, ANP, RN Linda D’Andrea, PNP, RN Lincy George, NP, RN Nicole Kowalewski, NP, RN Lorraine K. McEvoy, DNP, RN Annette Roman, RN Debra Rodrigue, RN Amparo Camacho, NP, RN Ester C. Dantis, PNP, RN Alison Gilgan, FNP, RN David R. Kraft, ANP, RN Shelley W. McKay, RN Hrafn Oli Sigurdsson, RN Wanda Rodriguez, RN Maryann Canavan, NP, RN Dorothea A. Dashiell, CPNP, RN Maryanne M. Giuliante, ANP, RN Nicole L. Kurtis, PNP, RN Patricia A. McTague-Allen, RN Shaneka D. Storey, RN Patricia Schaindlin, RN Joanne Lee Candela, ANP, RN Denise Dasti, ANP, RN Zlata Golubitskaya, AAHNP, RN Lauren Kushner, PNP, RN Kim Mertens, RN Inderani M. Walia, RN Rosemary Semler, RN Lisa Canecchia, NP, RN Deeann M. Davidson, ACNP, RN Winsome L. Grant, WHCNP, RN Kenny M. Lacossiere, ANP, RN Donna Miale-Mayer, RN Beth Sferrazza, RN Margaret Canjura, NP, RN Nancy J. DeGuzman, ANP, RN Randolph E. Gross, WHCNP, RN Liza Lee Lagdamen, NP, RN Annlouise Moran, BSN, MPH, RN, Kathleen Short, RN NE-BC Joanne M. Taylor, RN Elisabeth M. Wall, PhD, RN Eileen M. Walsh, RN Cecilia Watson, RN Donna J. Wilson, RN DEPARTMENTS OF MEMORIAL HOSPITAL DEPARTMENTS OF MEMORIAL HOSPITAL

Department of Nursing as of March 15, 2013 Division of Pharmacy Services as of March 15, 2013

Michelle Lange, NP, RN Kateri McGuire, CPNP, RN Nana Prempeh-Kete Ku, ANP, RN Dyana K. Sumner, CRNP, RN ASSOCIATE DIRECTORS CLINICAL COORDINATORS Edward Tyler, RPh Ethel B. Law, ANP, RN Julie Ellen Mcmahon, CPNP, RN Erin Punturieri, ANP, RN Marie Tait, NP, RN Stella Lee Eng, RPh Stern Bereth, RPh Frank Zappa, RPh Mary Layman-Goldstein, ANP, RN Julianne McNamara, FNP, RN Avery Putterman, CPNP, RN Yekaterina D. Tayban, ACNP, RN Scott Freeswick, RPh Zenia Bunyi, RPh Anthony Zinga, RPh Alexis Leitenberger, ANP, RN Margaret McSweeney, ACNP, RN Hilda Quintanilla, ANP, AOCNP, RN Jennifer Tempesta, NP, RN Raymond J. Muller, RPh Amelia Chan, RPh Angela Lentini-Rivera, CPNP, RN Carol Ann Milazzo-Kiedaisch, FNP, Coleen Ranaghan, NP, RN Janice Terlizzi, NP, RN Priti Patel, RPh Rachel Choi, RPh CLINICAL SPECIALISTS, ADULTS Nicole R. Leonhart, ANP, RN RN Robin Rawlins-Duell, ANP, RN Amanda Thomas, NP, RN Florina Chuy, RPh Manpreet Boparai, RPh Nicole LeStrange, ANP, RN Aida Milcetic, FNP, RN Sarah Rebal, NP, RN Ursula McPeak Tomlinson, CPNP, RN DIRECTOR SUPERVISORS Douglas Deritis, RPh Nina Cohen, RPh Erica G. Levinson, ANP, RN Grace Monger, CRNP, RN Tara A. Reilly, ACNP, RN Joanne E. Torok-Castanza, CPNP, RN Charles D. Lucarelli, RPh Barbara Beck-Camacho, RPh Joseph Galgano, RPh Thu Dang, RPh Isobel M. Lewis, FNP, RN Mary Montefusco, ACNP, RN Rebecca W. Repetti, ANP, RN Kathleen A. Trotta, ANP, RN Jerry Chow, RPh Dennis Grossano, RPh Stephen Harnicar, RPh Christine A. Liebertz, ANP, RN Joanna J. Moulton, CPNP, RN Martha Rodriguez, ANP, RN Roseann Tucci, CPNP, RN Jacqueline Gomes, RPh Peter Ho, RPh Andrew Lin, RPh Yi-Chih Lin, CPNP, RN Carolyn Mulryan, NP, RN Carol Rossetto, CPNP, RN Leslie Tyson, CRNP, RN Susan Murillo, RPh Alan Huang, RPh Sherry Mathew, RPh Camille L. Lineberry, ACNP, RN Yvette Murillo, FNP, RN Rose Ann Ruddy, ACNP, RN Jennifer Valdellon, ANP, RN Gerald O’Neill, RPh Ellie Kashani-Massoumi, RPh Angela Michael, RPh Ashley Linington, NP, RN Eibhlis Murray, FNP, RN Mary Rudzewick, ANP, RN Jill M. Vanak, ACNP, RN Melissa Lee-Teh, RPh Michael Kellick, RPh Alla Paskovaty, RPh Chhiu-Mei Liu, ANP, RN Joseph B. Narus, GNP, RN Julianne Ruggiero, CPNP, RN Amy P.Y. Vatanapradit, AACNP, RN Marie Ryan, RPh Mark Klang, RPh Marcin Puto, RPh Marie-Helene Lofland, ANP, RN Rachel O. Nebab, ACNP, RN Tara Russo, FNP, RN Nelly Vega-Woo, FNP, RN Dolores Sleiman, RPh Caroline Lau, RPh Hetal Shah, RPh Helen M. Loumeau, ANP, RN Teresa Nguyentran, NP, RN Jean Rutigliano, CPNP, RN Stephanie Vitolano, CPNP, RN John Timoney, RPh Diane Leone, RPh Richard Tizon, RPh Nadine Lugo, NP, RN Katherine G. O’Connor, ANP, RN Erin Ryan, ACNP, RN Kelly Vuksanaj, ANP, RN Jodi Wald, RPh Donna McGuffy, RPh Bhatt Valkal, RPh Andria D. Lyn, ACNP, RN Mary Ann P. O’Connor, FNP, RN Lina Saab, FNP, RN Christine D. Waters-Clayton, FNP, Elaine Yam, RPh Vivian Park, RPh Ryan Daley, RPh Peggy Lynch, CRNP, RN Siobhan O’Donnell, NP, RN Harpinderjit Sandhu, FNP, RN RN Karen Yeung, RPh Donald Murphy, RPh Joan Lynn, NP, RN Kristen Ohagan, ANP, RN Anita Schabel, ANP, RN Joanne Weiner, NP, RN Dena Rahman, RPh CLINICAL SPECIALISTS, Noelia Maamouri, ACNP, RN Shannon O’Keeffe, ACNP, RN Kristin Schaffner, NP, RN Richard Weiner, ANP, RN CLINICAL MANAGERS Barbara Simon, RPh PEDIATRICS Kelly M. Magee, FNP, RN Robert U. Okolie, NP, RN Mary A. Schoen, ANP, RN Alyona Weinstein, CRNP, RN Nelly Adel, RPh Pofan Sin, RPh Melissa Pozotrigo, RPh Suzanne Maier, CPNP, RN Marykate O’Rourke, ACNP, RN Nadia Schwenk, ANP, RN Joanne M. Wells, ANP, RN David Gregornik, RPh Yat Ling So, RPh Jennifer Thackray, RPh Jibran Majeed, NP, RN Claudia M. Ortiz, WHCNP, RN Barbara Seidel, ANP, RN Elizabeth H. Whittam, FNP, RN Gregory Stelzer, RPh Daniel Van Meter, RPh Michelle A. Mallamud, NP, RN Rosemary Ortiz, FNP, RN Jodi Selzer, FNP, RN Charles Wikle, NP, RN James Sumka, RPh Hallie Barr, RPh Jennifer L. Maloney, NP, RN Maria Pacis, ANP, RN Yelena Shames, ACNP, RN Kerry Williams, ANP, RN Frank Surita, RPh Brian Seyboth, RPh Nina Maresca, NP, RN Brima Padlan, ANP, RN Rosanne Sharp, ANP, RN Nadia Aziz Wilson, NP, RN Denise Margiotta, NP, RN Meighan Palazzo, NP, RN Caroline Shirzadi, NP, RN Gloria Y. Wong, ACNP, RN Kathryn Mariano, NP, RN Lauren Panico, NP, RN Kara Ann Singer, ANP, RN Christina M. Wray-Asaro, ACNP, RN Mariel Marrano, NP, RN Sylvia Pasieska, NP, RN Ana Sjoberg, ANP, RN Fengxin Wu, ACNP, RN Marie Kathlyn Marte, ANP, RN Alichia L. Paton, ACNP, RN Zeta Smikle-Hamilton, ANP, RN Jane Yoffe, FNP, RN Alison Massey, NP, RN Jennifer Pedulla, ANP, RN Tammy Son, ACNP, RN Joanna Yohannes-Tomicich, NP, RN Division of Social Work as of March 15, 2013 Leslie V. Matthews, ANP, RN Purnima Persaud, NP, RN Celeste M. Springer, ANP, RN Heidi M. Yulico, GNP, RN SENIOR CLINICAL STAFF RESOURCES FOR LIFE Shirley Mauzoul, ANP, RN Mary C. Petriccione, CPNP, RN Rebecca Steed, WHCNP, RN Nicole Zakak, CPNP, RN Margery Davis, LCSW AFTER CANCER Joanne Maynard, ANP, RN Katherine Picconi, FNP, RN Christine Stefanski, FNP, RN Joan M. Zatcky, ACNP, RN Rosalind Kleban, LCSW Penny Damaskos, PhD, LCSW Susan McCall, NP, RN Bobbi Pino-y-Torres, ANP, RN Deborah E. Stein, ACNP, RN Rebecca Zeuren, ANP, RN Anne Martin, PhD, LCSW Emily J. McCullagh, FNP, RN Joan M. Pope, ANP, RN Karen Stellato, NP, RN Joanna Zizzo, NP, RN Christine McGrade, FNP, RN Elaine M. Pottenger, CPNP, RN Rebecca Sturm, CPNP, RN

DIRECTOR Jane Bowling, DSW, LCSW PROGRAMS OF THE SLOAN-KETTERING INSTITUTE PROGRAMS OF THE SLOAN-KETTERING INSTITUTE

Steering Committee as of March 15, 2013 Cell Biology Program as of March 15, 2013

Kathryn V. Anderson, PhD Nikola P. Pavletich, PhD MEMBERS ASSISTANT MEMBERS AT THE ROCKEFELLER Eric M. Cottington, PnD Alexander Rudensky, PhD Raju S. K. Chaganti, PhD Emily A. Foley, PhD UNIVERSITY John R. Gunn David A. Scheinberg, MD, PhD William E. Snee Chair Cole M. Haynes, PhD Assistant Member (Affiliate) Alan Hall, PhD Craig B. Thompson, MD (ex officio) Filippo G. Giancotti, MD, PhD Jidong Liu, PhD Hironori Funabiki, PhD Joan Massagué, PhD Paul A. Marks, MD Philipp M. Niethammer, PhD Malcolm A. S. Moore, DPhil Michael H. Overholtzer, PhD AT WEILL CORNELL Enid A. Haupt Chair of Cell Biology DIRECTOR INTERIM DIRECTOR CHAIR AND MEMBER Meng-Fu Bryan Tsou, PhD MEDICAL COLLEGE Marilyn D. Resh, PhD (until March 10, 2013) (as of March 11, 2013) Alan Hall, PhD Member (Affiliate) Alfred P. Sloan Chair Urs Rutishauser, PhD Thomas J. Kelly, MD, PhD Kenneth J. Marians, PhD PROFESSIONAL SUPPORT STAFF Timothy A. Ryan, PhD William E. Snee Chair Benno C. Schmidt Chair Associate Laboratory Member of Cancer Research ASSOCIATE MEMBER Margaret A. Leversha, PhD Xuejun Jiang, PhD

Cancer Biology and Genetics Program as of March 15, 2013 Computational Biology Program as of March 15, 2013

MEMBERS ASSISTANT MEMBERS Associate Laboratory Membes ASSOCIATE MEMBERS ASSISTANT MEMBERS PROFESSIONAL SUPPORT STAFF Robert Benezra, PhD Kitai Kim, PhD Andrew C. Nicholson, DVM., PhD Gregoire Altan-Bonnet, PhD John D. Chodera, PhD Associate Laboratory Members Geoffrey Beene Junior Faculty Chair Bristol-Myers Squibb/James D. Joao de Bivar Xavier, PhD Raya Khanin, PhD Eric C. Holland, MD, PhD Robinson III Junior Faculty Chair Emily Tow Jackson Chair Christine Mayr, MD Nicholas D. Socci, PhD Assistant Laboratory Members Christina S. Leslie, PhD in Oncology Andrea Ventura, MD, PhD Christine Lieggi, DVM Gunnar Rätsch, PhD Scott W. Lowe, PhD Richard M. White, MD, PhD AT WEILL CORNELL Geoffrey Beene Senior Kerith R. Luchins, DVM CHAIR AND MEMBER MEDICAL COLLEGE CHAIR AND MEMBER Faculty Chair Sebastien Monette, DVM Chris Sander, PhD Member (Affiliate) Joan Massagué, PhD Craig B. Thompson, MD PROFESSIONAL SUPPORT STAFF Rodolfo J. Ricart-Arbona, DVM Alfred P. Sloan Chair; Tri-Institutional Professor Laboratory Members Julie White, DVM Harel Weinstein, DSc Howard Hughes Medical Ralph J. Garippa, PhD Institute Investigator ASSOCIATE MEMBERS Neil S. Lipman, VMD Johanna A. Joyce, PhD JOINT APPOINTMENT Felix R. Wolf, DVM, PhD Hans G. Wendel, MD Kenneth Offit, MD Developmental Biology Program as of March 15, 2013

MEMBERS ASSOCIATE MEMBERS ASSISTANT MEMBERS Mary K. Baylies, PhD Anna-Katerina Hadjantonakis, PhD Zhirong Bao, PhD Peter Besmer, PhD Eric C. Lai, PhD Mary G. Goll, PhD Maria Jasin, PhD Song-Hai Shi, PhD Danwei Huangfu, PhD William E. Snee Chair Bristol-Myers Squibb/James D. Julia A. Kaltschmidt, PhD Alexandra L. Joyner, PhD Robinson III Junior Faculty Chair Courtney Steel Chair in Pediatric Jennifer A. Zallen, PhD CHAIR AND MEMBER Cancer Research Howard Hughes Medical Institute PROFESSIONAL SUPPORT STAFF Kathryn V. Anderson, PhD Early Career Scientist Laboratory Members Enid A. Haupt Chair in Developmental Elizabeth H. Lacy, PhD Katia O. Manova-Todorova, PhD Biology Lorenz P. Studer, MD Willie H. Mark, PhD

Assistant Laboratory Members Peter J. Romanienko, PhD Mark J. Tomishima, PhD PROGRAMS OF THE SLOAN-KETTERING INSTITUTE PROGRAMS OF THE SLOAN-KETTERING INSTITUTE

Immunology Program as of March 15, 2013 Molecular Pharmacology and Chemistry Program as of March 15, 2013

MEMBERS ASSISTANT MEMBER JOINT APOPINTMENTS MEMBERS Neal Rosen, MD, PhD Associate Laboratory Members Michael S. Glickman, MD Joseph C. Sun, PhD Ronald P. DeMatteo, MD Colin B. Begg, PhD Enid A. Haupt Chair in Medical Elisa de Stanchina, PhD Oncology Alfred P. Sloan Chair Leslie H. Blumgart Chair in Surgery Eugene W. Kettering Chair Lee J. McDonald, PhD Michel Sadelain, MD, PhD Alan N. Houghton, MD PROFESSIONAL SUPPORT STAFF Katharine C. Hsu, MD, PhD Ronald G. Blasberg, MD Ouathek Ouerfelli, PhD Virginia and Daniel K. Stephen and Barbara Friedman Chair Laboratory Member Jedd D. Wolchok, MD, PhD Murray F. Brennan, MD George D. Sukenick, PhD Ludwig Clinical Chair Benno C. Schmidt Chair in Clinical Peter T. Scardino, MD Tullia Lindsten, MD, PhD James W. Young, MD Richard J. O’Reilly, MD Oncology David H. Koch Chair Nian Wu, PhD CHAIR AND MEMBER CHAIR AND MEMBER Claire L. Tow Chair in Bayard D. Clarkson, MD Derek S. Tan, PhD David A. Scheinberg, MD, PhD Alexander Y. Rudensky, PhD Pediatric Oncology Research Associate Laboratory Members Enid A. Haupt Chair of Therapeutic Assistant Laboratory Members Howard Hughes Medical Vincent Astor Chair Eric G. Pamer, MD P. Jan Hendrikx, PhD Research ASSOCIATE MEMBER Christophe Antczak, PhD Institute Investigator Enid A. Haupt Chair in Frances Weis-Garcia, PhD Samuel J. Danishefsky, PhD Ying-Xian Pan, PhD Clinical Investigation Gabriela Chiosis, PhD Phillip Wong, PhD Eugene W. Kettering Chair Maria K. Spassova, PhD Marcel R. M. van den Brink, Zvi Fuks, MD Xiuyan Wang, PhD MD, PhD Alfred P. Sloan Chair ASSISTANT MEMBERS Assistant Laboratory Members Luca Cartegni, PhD Alan N. Houghton Chair Hedvig Hricak, MD, PhD Annamalai Selvakumar, PhD Carroll and Milton Petrie Chair Jan Grimm, MD, PhD AT CORNELL UNIVERSITY ASSOCIATE MEMBERES Jianda Yuan, MD, PhD Richard N. Kolesnick, MD Daniel A. Heller, PhD Assistant Member (Affiliate) Jayanta Chaudhuri, PhD Steven M. Larson, MD Michael G. Kharas, PhD Hening Lin, PhD Morgan Huse, PhD Donna and Benjamin M. Rosen Chair Minkui Luo, PhD in Radiology Ming Li, PhD AT THE ROCKEFELLER Yueming Li, PhD PROFESSIONAL SUPPORT STAFF UNIVERSITY Gavril W. Pasternak, MD, PhD Laboratory Members Assistant Member (Affilaite) Anne Burnett Tandy Chair of Sean Brady, PhD Neurology Ting-Chao Chou, PhD Jerome B. Posner, MD Hakim Djaballah, PhD American Cancer Society Clinical Ronald C. Hendrickson, PhD JOINT APPOINTMENTS Molecular Biology Program as of March 15, 2013 Research Professor; George C. Cotzias Isabelle Rivière, PhD Michelle S. Bradbury, MD, PhD Chair of Neuro-Oncology Renier J. Brentjens, MD, PhD MEMBERS ASSOCIATE MEMBER AT THE ROCKEFELLER Jason A. Koutcher, MD, PhD Jerard Hurwitz, PhD Xiaolan Zhao, PhD UNIVERSITY Jason S. Lewis, PhD Prasad V. Jallepalli, MD, PhD Member (Affiliate) Vladimir Ponomarev, MD, PhD Scott N. Keeney, PhD ASSISTANT MEMBERS C. David Allis, PhD Woflgang A. Weber, MD Howard Hughes Medical Xiaohui Qu, PhD Institute Investigator Dirk Remus, PhD JOINT APPOINTMENT Thomas J. Kelly, MD, PhD CHAIR AND MEMBER Benno C. Schmidt Chair of Iestyn Whitehouse, PhD Simon N. Powell, MD, PhD Structural Biology Program as of March 15, 2013 Enid A. Haupt Chair in Kenneth J. Marians, PhD Cancer Research William E. Snee Chair Radiation Oncology Andrew Koff, PhD PROFESSIONAL SUPPORT STAFF MEMBERS ASSISTANT MEMBERS PROFESSIONAL SUPPORT STAFF John H. J. Petrini, PhD Laboratory Members Jonathan D. Goldberg, PhD Stephen B. Long, PhD Associate Laboratory Member Paul A. Marks Chair in Hediye Erdjument Bromage, PhD Stephen and Barbara Friedman Chair; Alexandros Pertsinidis, PhD Yehuda Goldgur, PhD Molecular Cell Biology Howard Hughes Medical Institute Agnès Viale, PhD Investigator Mark S. Ptashne, PhD Virginia and Daniel K. Ludwig Chair Associate Laboratory Member Christopher D. Lima, PhD Stewart Shuman, MD, PhD Dimitar B. Nikolov, PhD Ricardo Toledo-Crow, PhD CHAIR AND MEMBER Simon H. Rifkind Chair Dinshaw Patel, PhD Nikola P. Pavletich, PhD Paul Tempst, PhD Assistant Laboratory Member Abby Rockefeller Mauzé Chair of Stephen and Barbara Friedman Chair; Experimental Therapeutics Mariana M. Yaneva, PhD Howard Hughes Medical Institute Investigator MEMBERS EMERITI MEMORIAL SLOAN-KETTERING CANCER CENTER

Lowell L. Anderson, PhD Susan E. Krown, MD Stuart H. Q. Quan, MD Elliot W. Strong, MD Donald Armstrong, MD Marguerite S. Lederberg, MD Richard A. Rifkind, MD Osias Stutman, MD Ronald A. Castellino, MD Philip H. Lieberman, MD Lawrence N. Rothenberg, PhD Alan D. Turnbull, MD E. Eugene Covington, MD C. Clifton Ling, PhD F. Kingsley Sanders, DPhil Norma Wollner, MD Bo Dupont, MD, DSc Kenneth O. Lloyd, PhD Morton K. Schwartz, PhD James M. Woodruff, MD Thomas J. Fahey, Jr., MD Klaus Mayer, MD Maurice E. Shils, MD, ScD Samuel D. J. Yeh, MD, ScD Joseph H. Galicich, Jr., MD Myron R. Melamed, MD Francis M. Sirotnak, PhD Robert B. Golbey, MD W. P. Laird Myers, MD Maus W. Stearns, MD Walter B. Jones, MD Manuel Ochoa, Jr., MD Stephen S. Sternberg, MD