April 26 - 28, 2013 Chicago, IL, USA

Friday, April 26 8:00 a.m. - 7:00 p.m. On-Site APSA Registraon Internaonal Foyer

8:30 a.m. – 12:30 p.m. APSA Business Meeng Moulin Rouge

1:00 p.m. – 3:00 p.m. Poster Setup Imperial Ballroom

12:30 p.m. – 3:30 p.m. APSA Plenary Session Moulin Rouge

12:30 p.m. –1:00 p.m. APSA Keynote “Public Scholarship and the Role of Sciensts” Debra Houry, MD, MPH Emory University School of Medicine SAEM (Society for Academic Emergency Medicine) Sponsored Talk

1:00 p.m. – 1:30 p.m. APSA Keynote “Cardiac Growth and Regeneraon” Jonathan A. Epstein, MD Perelman School of Medicine at the University of Pennsylvania

2:00 p.m. – 3:00 p.m. Women in Medicine Panel Moderator: Jill M. Baren, MD Perelman School of Medicine at the University of Pennsylvania Panelists: Juliane Bubeck Wardenburg, MD, PhD University of Chicago School of Medicine

Gail E. Tomlinson, MD, PhD University of Texas Medical School at San Antonio

Melanie B. Thomas, MD, MS Medical University of South Carolina College of Medicine

3:00 p.m. – 3:30 p.m. APSA Keynote “The Cancer Genome in Biology and Cancer Therapy” Levi A. Garraway, MD, PhD Harvard Medical School, Dana-Farber Cancer Instute

3:30 p.m. – 6:00 p.m. Plenary Session I Internaonal Ballroom Understanding Disease Mechanisms to Improve Human Health Moderators: Warner C. Greene, Peter Tontonoz, and Taylor Heald-Sargent

3:30 p.m. – 4:00 p.m. “Scaling up the Potenal of Clinical Research” Francis S. Collins, MD, PhD Naonal Instutes of Health

4:00 p.m. – 4:30 p.m. “Hepas C: Is the End in Sight?” Charles Rice, PhD Rockefeller University

4:30 p.m. – 4:45 p.m. Presentaon of Career Development Awards

4:45 p.m. – 5:15 p.m. “Mitochondrial Protein Acylaon and Metabolic Regulaon” Eric Verdin, MD Gladstone Instutes, UCSF

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Friday April 26 (cont.)

5:15 p.m. – 5:45 p.m. “Inducon of Pluripotency by Defined Factors.” Shinya Yamanaka, MD, PhD Center for iPS Cell Research and Applicaon (CiRA), Japan and Gladstone Ins- tutes, UCSF

5:45 p.m. – 6:00 p.m. Q&A

7:00 p.m. – 9:00 p.m. AAP Offsite President's Dinner (by invitaon only) Mid America Club 7:00 p.m. – 9:00 p.m. ASCI Annual Dinner/Introducon of New Members Moulin Rouge (cketed guests only) “Clinical Research: The Uphill Climb” David G. Nathan, MD Harvard Medical School, Dana-Farber Cancer Instute

7:00 p.m. – 9:00 p.m. APSA Dinner Oungs Sign up at the Meeting Registration Desk outside the International Ballroom. Groups will meet by the Registraon Desk at the Fairmont Hotel Restaurants: The Gage, Hot Woks Cool Sushi - Willis Tower, Sappori Trattoria, Gino's East, The Purple Pig

9:00 p.m. – Midnight APSA Welcome Recepon Willis Tower Skydeck (99th Floor) Shules depart from the lower level APSA Presidenal Address Dania Daye, MD, PhD Candidate HHMI-NIBIB Interfaces Scholar, University of Pennsylvania School of Medicine

Saturday, April 27 7:00 a.m. – 5:00 p.m. On-site APSA Registraon Internaonal Foyer

7:00 a.m. – 8:15 a.m. Young Invesgators Mentoring Breakfast (cket required) Moulin Rouge Sign up at the Meeting Registration Desk outside the International Ballroom

8:15 a.m. – 11:15 a.m. Plenary Session II Internaonal Ballroom Understanding Disease Mechanisms to Improve Human Health Moderators: J. Larry Jameson, William C. Hahn, and Dania Daye

8:15 a.m. – 8:45 a.m. “Reflecons of a Former MSTP Director on Physician/ Scienst Training” Kevin Shannon, MD University of California, San Francisco

8:45 a.m. – 9:15 a.m. “Developing New Prostate Cancer Drugs” Charles Sawyers, MD Memorial Sloan-Keering Cancer Center

9:15 a.m. – 9:30 a.m. APSA Oral Abstract Presentaon “Role of FRS2 and FGF/FGFR Autocrine Signaling in the Proliferaon of Ovarian Cancer Cells” Leo Y. Luo, BS Broad Instute of Harvard and MIT

9:30 a.m. –10:00 a.m. “Direct Cardiac Reprogramming: From Developmental Biology to Regeneraon” Deepak Srivastava, MD Gladstone Instute

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Saturday, April 27 (cont.) 10:00 a.m. – 10:30 a.m. Break Internaonal Foyer 10:30 a.m. - 11:00 a.m. “Novel Mechanisms by Which Adipose Tissue Regulates Systemic Insulin Sensivity and the Risk for Diabetes” Barbara Kahn, MD Harvard Medical School, Beth Israel Deaconess Medical Center

11:00 a.m. -11:15 a.m. APSA Oral Abstract Presentaon “Heat Shock Protein 70 Demonstrates IL-10 Mediated Immune Modulaon in Experimental Colis” InYoung Kim, PhD University of Chicago

11:15 a.m. -11:30 a.m. “Unifying Role for Prions in Degenerave Diseases” Stanley Prusiner, MD University of California, San Francisco

11:45 a.m. – 1:30 p.m. Poster Session with Lunch Imperial Ballroom Presenters should be at poster during the assigned me

1:30 p.m. – 2:00 p.m. Poster Dismantle 1:30 p.m. – 3:00 p.m. ASCI and AAP New Member Presentaons Internaonal Ballroom Moderators: Paul Rothman, Mukesh Jain, and Evan Noch

1:30 p.m. - 1:50 p.m. “Telomerase and Idiopathic Pulmonary Fibrosis” Mary Armanios, MD (New ASCI Member) Johns Hopkins University School of Medicine

1:50 p.m. - 2:10 p.m. “VEGF and the Glomerular Barrier — Two Sides to the Story” Susan Quaggin, MD (New AAP Member) Northwestern University

2:10 p.m. - 2:30 p.m. “Regulaon of the Dendric Cell and Macrophage Lineage” Miriam Merad, MD, PhD (New ASCI Member) Mount Sinai School of Medicine

2:30 p.m. - 2:50 p.m. “Treang the Untreatable: An Exome Sequencing Approach in Neurodevelopmental Disease” Joseph Gleeson, MD (New AAP Member) University of California, San Diego

1:30 p.m. – 2:15 p.m. APSA Breakout Sessions: Residency 101: Gold Room Moderator: M. Kerry O'Banion, MD, PhD, University of Rochester Panelists: James K. Liao, MD University of Chicago

Nicole Grieselhuber, MD, PhD The Ohio State University Internal Medicine

David Scoville, MS, MD, PhD Stanford Integrated Cardiothoracic Surgery

Wring for Basic Science and Clinical Journals: Crystal Room Moderator: David Markovitz, MD University of Michigan Panelists: Howard A. Rockman, MD (Editor-in-Chief, JCI)

Howard C. Bauchner, MD (Editor-in-Chief, JAMA)

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Saturday, April 27 (cont.) 2:30 p.m. – 3:15 p.m. APSA Policy Panel Gold Room Moderator: Barry S. Coller, MD, Rockefeller University Panelists: Francis S. Collins, MD, PhD, Naonal Instutes of Health

Michael R. Bristow, MD, PhD, University of Colorado

Ananda M. Chakrabarty, PhD, University of Illinois, Chicago

3:00 p.m. – 3:30 p.m. Break Internaonal Ballroom foyer

3:30 p.m. - 3:50 p.m. “Mapping the Origins of Cancer” Internaonal Ballroom Richard James Gilbertson, MD, PhD (New ASCI Member) St. Jude Children’s Research Hospital

3:50 p.m. – 4:10 p.m. “The Search for Disease Genes: What Mendel Can Tell us About Medicine” David Valle, MD (New AAP Member) Johns Hopkins University School of Medicine

4:10 p.m. – 4:45 p.m. APSA Keynote Internaonal Ballroom “Epstein-Barr Virus: From Bench to Bedside” Shannon C. Kenney, MD University of Wisconsin-Madison School of Medicine and Public Health IDSA (Infecous Diseases Society of America) sponsored talk

4:45 p.m. – 5:00 p.m. APSA Oral Abstract Presentaon “T-bet Dictates CD8+ T Cell Tolerance Versus Immunity Following Angen Recognion” Stephanie R. Jackson, BSE, MS Saint Louis University School of Medicine

5:00 p.m. – 5:30 p.m. AAP Presidenal Address “Seeking Sustainable Soluons to Global Health Challenges: No More Band-Aids” Warner C. Greene, MD, PhD Gladstone Instute, University of California, San Francisco

5:30 p.m. – 6:00 p.m. ASCI Presidenal Address: “The Perfect Storm: Challenges and Opportunies for Translaonal Research William C. Hahn, MD, PhD Harvard Medical School, Dana-Farber Cancer Instute

7:30 p.m. – 9:00 p.m. APSA Dinner (cket required– black e oponal) Moulin Rouge “Don't Get Bit: How Expedions Drive Clinical Research” Mahew Lewin, MD, PhD, FACEP Center for Exploraon and Travel Health, California Academy of Sciences

9:00 p.m. – 10:00 p.m. APSA dinner aendees join AAP members for dinner speaker “A Funny Thing Happened on the Way to Stockholm” Robert Leowitz, MD Duke University

10:00 p.m. – Midnight Dessert Recepon (open to all aendees) Imperial Ballroom Foyer

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Sunday, April 28

7:00 a.m. – 8:15 a.m. Young Invesgators Mentoring Breakfast (cket required) Moulin Rouge Sign up at the Meeting Registration Desk outside the International Ballroom

8:00 a.m. – Noon Plenary Session III Internaonal Ballroom Understanding Disease Mechanisms to Improve Human Health Moderators: Warner C. Greene, William C. Hahn, and Katherine Hartmann 8:00 a.m. – 8:20 a.m. AAP Business Meeng

8:20 a.m. – 8:30 a.m. Best Poster Award Presentaon

8:30 a.m. – 9:15 a.m. Kober Medal Presentaon & Lecture Recipient: John T. Pos, Jr., MD Massachuses General Hospital

Presenter: J. Larry Jameson Perelman School of Medicine, University of Pennsylvania

9:15 a.m. – 10:00 a.m. ASCI/Stanley J. Korsmeyer Award Lecture Bruce Beutler, MD UT Southwestern Medical Center

10:00 a.m. – 10:45 a.m. “Targeng the Gut to Treat the Heart” Stanley Hazen, MD, PhD Cleveland Clinic

10:45 a.m. – 11:15 a.m. APSA Oral Abstract Presentaon Internaonal Ballroom “Systemic Type I Interferons Indirectly Promote Epithelial Proliferaon and Turnover” Lulu Sun, BSc Washington University in Saint Louis University School of Medicine 11:15 a.m. – Noon APSA Keynote “MRI: From Science to Society” Vivian S. Lee, MD, PhD, MBA University of Utah RSNA (Radiological Society of North America) sponsored talk

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Sunday, April 28 (cont.) Noon – 1:00 p.m. APSA Post Graduate Opportunies Panel Internaonal Ballroom Moderator: Lawrence (Skip) Brass, MD, PhD Perelman School of Medicine, University of Pennsylvania Panelists: Sapan S. Desai, MD, PhD, MBA, CEO and President Surgisphere Corporaon; University of Texas at Houston; Duke University

Dianna M. Milewicz, MD, PhD University of Texas Medical School at Houston

Griffin P. Rodgers, MD, PhD, MBA Naonal Instute of Diabetes and Digesve and Kidney Diseases (NIDDK)

1:00 p.m. – 2:30 p.m. APSA Residency Luncheon (Free for all registered aendees) Moulin Rouge

Brigham and Women’s Internal Medicine Residency Program

Cincinna Children’s Physician Scienst Training Program

Naonal Instutes of Health (NIH) Clinical Programs

Northwestern Physician Scienst Training Program

Ohio State Internal Medicine

University of Chicago Pathology

University of Chicago Physician Scienst Development Program

University of Minnesota

University of Pennsylvania Emergency Medicine

University of Rochester Research Residency Track

Vanderbilt University Physician Scienst Training Program

University of Iowa Physician Scienst Training Program

University of Texas at Southwestern Medical Center at Dallas Physician Scienst Training Program

University of Southern California Children’s Hospital Los Angeles’ Donnell Society for Physician Sciensts

Yale University Physician Scienst Training Program

2:30 p.m. – 3:30 p.m. APSA Execuve Council Meeng Gold Room (All newly elected members must aend)

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