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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Unrestricted Immigration and the Foreign Dominance Of
Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Table of Contents (PDF)
June 28, 2016 u vol. 113 u no. 26 From the Cover 7106 Topological defects in liquid crystals E3619 Translation control in Fragile X syndrome E3686 Voltage-sensing phosphatase activities E3782 Aerobic glycolysis and learning 7261 Electric field sensing by bumblebees Contents THIS WEEK IN PNAS Cover image: Pictured is a polarized 7003 In This Issue optical micrograph of a plastic sheet with an array of holes drilled into it and suspended in a nematic-phase liquid LETTERS (ONLINE ONLY) crystal. Lisa Tran et al. found that such a sheet induced arrays of topological E3590 Reduced nitrogen dominated nitrogen deposition in the United States, but its defect lines in a nematic liquid crystal. contribution to nitrogen deposition in China decreased The authors further demonstrated how Xuejun Liu, Wen Xu, Enzai Du, Yuepeng Pan, and Keith Goulding the energy of the liquid crystal and the E3592 Reply to Liu et al.: On the importance of US deposition of nitrogen dioxide, geometry of the holes affect the defect coarse particle nitrate, and organic nitrogen patterns. The findings might have Yi Li, Bret A. Schichtel, John T. Walker, Donna B. Schwede, Xi Chen, Christopher M. B. applications in electronic displays, Lehmann, Melissa A. Puchalski, David A. Gay, and Jeffrey L. Collett Jr. where nematic liquid crystals are widely used. See the article by Tran et al. on E3594 Rise and fall of nitrogen deposition in the United States pages 7106–7111. Image courtesy of Enzai Du Lisa Tran. E3596 Adult pelvic shape change is an evolutionary side effect Philipp Mitteroecker and Barbara Fischer E3597 Reply to Mitteroecker and Fischer: Developmental solutions to the obstetrical dilemma are not Gouldian spandrels Marcia S. -
Die Woche Spezial
In cooperation with DIE WOCHE SPEZIAL >> Autographs>vs.>#NobelSelfie Special >> Big>Data>–>not>a>big>deal,> Edition just>another>tool >> Why>Don’t>Grasshoppers> Catch>Colds? SCIENCE SUMMIT The>64th>Lindau>Nobel>Laureate>Meeting> devoted>to>Physiology>and>Medicine More than 600 young scientists came to Lindau to meet 37 Nobel laureates CAREER WONGSANIT > Women>to>Women: SUPHAKIT > / > Science>and>Family FOTOLIA INFLAMMATION The>Stress>of>Ageing > FLASHPICS > / > MEETINGS > FOTOLIA LAUREATE > CANCER RESEARCH NOBEL > LINDAU > / > J.>Michael>Bishop>and GÄRTNER > FLEMMING > JUAN > / the>Discovery>of>the>first> > CHRISTIAN FOTOLIA Human>Oncogene EDITORIAL IMPRESSUM Chefredakteur: Prof. Dr. Carsten Könneker (v.i.S.d.P.) Dear readers, Redaktionsleiter: Dr. Daniel Lingenhöhl Redaktion: Antje Findeklee, Jan Dönges, Dr. Jan Osterkamp where>else>can>aspiring>young>scientists> Ständige Mitarbeiter: Lars Fischer Art Director Digital: Marc Grove meet>the>best>researchers>of>the>world> Layout: Oliver Gabriel Schlussredaktion: Christina Meyberg (Ltg.), casually,>and>discuss>their>research,>or>their> Sigrid Spies, Katharina Werle Bildredaktion: Alice Krüßmann (Ltg.), Anke Lingg, Gabriela Rabe work>–>or>pressing>global>problems?>Or> Verlag: Spektrum der Wissenschaft Verlagsgesellschaft mbH, Slevogtstraße 3–5, 69126 Heidelberg, Tel. 06221 9126-600, simply>discuss>soccer?>Probably>the>best> Fax 06221 9126-751; Amtsgericht Mannheim, HRB 338114, UStd-Id-Nr. DE147514638 occasion>is>the>annual>Lindau>Nobel>Laure- Geschäftsleitung: Markus Bossle, Thomas Bleck Marketing und Vertrieb: Annette Baumbusch (Ltg.) Leser- und Bestellservice: Helga Emmerich, Sabine Häusser, ate>Meeting>in>the>lovely>Bavarian>town>of> Ute Park, Tel. 06221 9126-743, E-Mail: [email protected] Lindau>on>Lake>Constance. Die Spektrum der Wissenschaft Verlagsgesellschaft mbH ist Kooperati- onspartner des Nationalen Instituts für Wissenschaftskommunikation Daniel>Lingenhöhl> GmbH (NaWik). -
Aaron Ciechanover 2004 Nobel Laureate in Chemistry
TRINITY COLLEGE DUBLIN Medical Research at the Cutting Edge Progress in the fight against Inflammatory Diseases and Cancer Joint Symposium of the Trinity Biomedical Sciences Institute and The Weizmann Institute of Science Tercentenary Hall, Trinity Biomedical Sciences Institute Keynote Speakers July 27-29, 2014 Bruce Beutler 2011 Nobel Laureate in Speakers Physiology and Medicine Opening Address Minister Sean Sherlock TD, University of Texas Minister for Research and Innovation, Irish Government. Aaron Ciechanover Ireland Israel 2004 Nobel Laureate in Chemistry Luke O’Neill Ruth Arnon Technion Israel Institute of TBSI Academic Director The President of the Israel Academy of Technology Diarmuid O’Brien Sciences and Humanities Director of Trinity Research and Mudi Sheves Marc Feldmann Innovation The Weizmann Institute of Science 2003 Albert Lasker Award Andrew Bowie Vice President for Technology Transfer for Clinical Medical Research Trinity Biomedical Sciences Inst. Ido Amit University of Oxford Paul Brown Weizmann Institute of Science England Trinity College Dublin Yinon Ben-Neriah Martin Caffrey Hebrew Univ. of Jerusalem Jules Hoffmann Trinity Biomedical Sciences Inst. 2011 Nobel Laureate in Ashraf Brik Gavin Davey Physiology and Medicine Ben Gurion University Trinity Biomedical Sciences Inst. Institut de Biologie Moleculaire Steffen Jung et Cellulaire, France Aisling Dunne Trinity Biomedical Sciences Inst. Weizmann Institute of Science James Watson Padraic Fallon Eran Elinav 1962 Nobel Laureate in Trinity Biomedical Sciences Inst. Weizmann Institute of Science Physiology and Medicine Alan Irvine Yehuda Kamari Cold Spring Harbor Laboratory Trinity College Dublin Sheba Medical Center New York Vincent Kelly Irit Sagi Trinity Biomedical Sciences Inst. Weizmann Institute of Science Ada Yonath Seamus Martin Idit Shachar 2009 Nobel Laureate in Trinity College Dublin Weizmann Institute of Science Chemistry Kingston Mills David Wallach Weizmann Institute of Science, Trinity Biomedical Sciences Inst. -
Nobel Endeavors in Immunology Introducing Dr
SPRING 2012 A PUBLICATION OF SOUTHWESTERN MEDICAL FOUNDATION Nobel Endeavors in Immunology Introducing Dr. Bruce Beutler, UT Southwestern’s fifth Nobel Laureate, and the new Center for the Genetics of Host Defense Southwestern Medical Foundation Board of Trustees 2011-2012 Edward M. Ackerman Joe M. Haggar, III Richard R. Pollock Sara Melnick Albert Nancy S. Halbreich Caren H. Prothro The Heritage Society Rafael M. Anchia LaQuita C. Hall Carolyn Perot Rathjen OF SOUTHWESTERN MEDICAL FOUNDATION Table of Contents Charlotte Jones Anderson Paul W. Harris* Mike Rawlings table of contents Barry G. Andrews Linda W. Hart Jean W. Roach Joyce T. Alban Mr. and Mrs. Thomas E. McCullough Marilyn H. Augur Joe V. (Jody) Hawn, Jr. Linda Robuck Mr. and Mrs. James R. Alexander Christopher F. McGratty Robert D. Rogers Ralph W. Babb, Jr. Jess T. Hay Anonymous (11) Carmen Crews McCracken McMillan Editor Doris L. Bass Frederick B. Hegi, Jr. Catherine M. Rose George A. Atnip# Ferd C. and Carole W. Meyer Nobel Endeavors in Immunology Peter Beck Jeffrey M. Heller* Billy Rosenthal Marilyn Augur* William R. and Anne E. Montgomery Heidi Harris Cannella The threads of Dr. Bruce Beutler’s scientific 3 # Jill C. Bee Julie K. Hersh Lizzie Horchow Routman* Paul M. Bass* Kay Y. Moran career are inextricably woven into the fabric of W. Robert Beavers, M.D. Barbara and Robert Munford Gil J. Besing Thomas O. Hicks Robert B. Rowling* Creative Director UT Southwestern’s history. From intern to mid-career Drs. Paul R. and Robert H. Munger# Jan Hart Black Sally S. Hoglund Stephen H. -
Five Great Ideas of Biology
GREATGREAT IDEASIDEAS OFOF BIOLOGYBIOLOGY Paul Nurse KITP Public Lecture, Feb 24, 2010 THETHE CELLCELL The basic unit of life ROBERTROBERT HOOKEHOOKE’’SS MICROSCOPEMICROSCOPE Cork Image: Past Present STEMSTEM IMAGES:IMAGES: PASTPAST ANDAND PRESENTPRESENT Nehemiah Grew (1682) ANTONIANTONI VANVAN LEEUWENHOEKLEEUWENHOEK MICROORGANISMSMICROORGANISMS VANVAN LEEUWENHOEK?LEEUWENHOEK? THEODORTHEODOR SCHWANNSCHWANN “We have seen that all organisms are composed of essentially like parts, namely, of cells.” (1839) RUDOLFRUDOLF VIRCHOWVIRCHOW “Every animal appears as a sum of vital units, each of which bears in itself the complete characteristics of life.” (1858) CELLCELL Rockefeller Nobel Prize Winners in Cell Biology George E. Palade (1974) Christian de Duve (1974) Albert Claude (1974) Günter Blobel (1999) MAMMALIANMAMMALIAN EMBRYOEMBRYO SPERMSPERM ANDAND EGGEGG THETHE CELLCELL The basic unit of life Underpins all reproduction and development Stem cells THETHE GENEGENE Basis of heredity GREGORGREGOR MENDELMENDEL MENDELMENDEL’’SS GARDENGARDEN PEASPEAS PEASPEAS 1919TH CENTURYCENTURY CHROMOSOMESCHROMOSOMES EDOUARDEDOUARD VANVAN BENEDENBENEDEN’’SS NEMATODENEMATODE CHROMOSOMESCHROMOSOMES PNEUMOCOCCUSPNEUMOCOCCUS Avery, MacLeod and McCarty, Rockefeller University (1944) DNADNA MOLECULEMOLECULE CENTRALCENTRAL DOGMADOGMA THETHE GENEGENE Basis of heredity Genotype to phenotype Implications for what we are EVOLUTIONEVOLUTION BYBY NATURALNATURAL SELECTIONSELECTION Life evolves Mechanism of natural selection ERASMUSERASMUS ANDAND CHARLESCHARLES DARWINDARWIN -
Biographical References for Nobel Laureates
Dr. John Andraos, http://www.careerchem.com/NAMED/Nobel-Biographies.pdf 1 BIOGRAPHICAL AND OBITUARY REFERENCES FOR NOBEL LAUREATES IN SCIENCE © Dr. John Andraos, 2004 - 2021 Department of Chemistry, York University 4700 Keele Street, Toronto, ONTARIO M3J 1P3, CANADA For suggestions, corrections, additional information, and comments please send e-mails to [email protected] http://www.chem.yorku.ca/NAMED/ CHEMISTRY NOBEL CHEMISTS Agre, Peter C. Alder, Kurt Günzl, M.; Günzl, W. Angew. Chem. 1960, 72, 219 Ihde, A.J. in Gillispie, Charles Coulston (ed.) Dictionary of Scientific Biography, Charles Scribner & Sons: New York 1981, Vol. 1, p. 105 Walters, L.R. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 328 Sauer, J. Chem. Ber. 1970, 103, XI Altman, Sidney Lerman, L.S. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 737 Anfinsen, Christian B. Husic, H.D. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 532 Anfinsen, C.B. The Molecular Basis of Evolution, Wiley: New York, 1959 Arrhenius, Svante J.W. Proc. Roy. Soc. London 1928, 119A, ix-xix Farber, Eduard (ed.), Great Chemists, Interscience Publishers: New York, 1961 Riesenfeld, E.H., Chem. Ber. 1930, 63A, 1 Daintith, J.; Mitchell, S.; Tootill, E.; Gjersten, D., Biographical Encyclopedia of Scientists, Institute of Physics Publishing: Bristol, UK, 1994 Fleck, G. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 15 Lorenz, R., Angew. -
George Palade 1912-2008
George Palade, 1912-2008 Biography George Palade was born in November, 1912 in Jassy, Romania to an academic family. He graduated from the School of Medicine of the The Founding of Cell Biology University of Bucharest in 1940. His doctorial thesis, however, was on the microscopic anatomy of the cetacean delphinus Delphi. He The discipline of Cell Biology arose at Rockefeller University in the late practiced medicine in the second world war, and for a brief time af- 1940s and the 1950s, based on two complimentary techniques: cell frac- terwards before coming to the USA in 1946, where he met Albert tionation, pioneered by Albert Claude, George Palade, and Christian de Claude. Excited by the potential of the electron microscope, he Duve, and biological electron microscopy, pioneered by Keith Porter, joined the Rockefeller Institute for Medical Research, where he did Albert Claude, and George Palade. For the first time, it became possible his seminal work. He left Rockefeller in 1973 to chair the new De- to identify the components of the cell both structurally and biochemi- partment of Cell Biology at Yale, and then in 1990 he moved to the cally, and therefore begin understanding the functioning of cells on a University of California, San Diego as Dean for Scientific Affairs at molecular level. These individuals participated in establishing the Jour- the School of Medicine. He retired in 2001, at age 88. His first wife, nal of Cell Biology, (originally the Journal of Biochemical and Biophysi- Irina Malaxa, died in 1969, and in 1970 he married Marilyn Farquhar, cal Cytology), which later led, in 1960, to the organization of the Ameri- another prominent cell biologist, and his scientific collaborator. -
Evidence for Design in Physics and Biology: from the Origin of the Universe to the Origin of Life
52 stephen c. meyer Pages 53–111 of Science and Evidence for Design in the Universe. The Proceedings of the Wethersfield Institute. Michael Behe, STEPHEN C. MEYER William A. Dembski, and Stephen C. Meyer (San Francisco: Ignatius Press, 2001. 2000 Homeland Foundation.) EVIDENCE FOR DESIGN IN PHYSICS AND BIOLOGY: FROM THE ORIGIN OF THE UNIVERSE TO THE ORIGIN OF LIFE 1. Introduction In the preceding essay, mathematician and probability theo- rist William Dembski notes that human beings often detect the prior activity of rational agents in the effects they leave behind.¹ Archaeologists assume, for example, that rational agents pro- duced the inscriptions on the Rosetta Stone; insurance fraud investigators detect certain ‘‘cheating patterns’’ that suggest intentional manipulation of circumstances rather than ‘‘natu- ral’’ disasters; and cryptographers distinguish between random signals and those that carry encoded messages. More importantly, Dembski’s work establishes the criteria by which we can recognize the effects of rational agents and distinguish them from the effects of natural causes. In brief, he shows that systems or sequences that are both ‘‘highly com- plex’’ (or very improbable) and ‘‘specified’’ are always produced by intelligent agents rather than by chance and/or physical- chemical laws. Complex sequences exhibit an irregular and improbable arrangement that defies expression by a simple formula or algorithm. A specification, on the other hand, is a match or correspondence between an event or object and an independently given pattern or set of functional requirements. As an illustration of the concepts of complexity and speci- fication, consider the following three sets of symbols: 53 54 stephen c. -
Allergy – What’S in a Name?
HISTORY OF ENT Allergy – what’s in a name? BY KATHERINE CONROY llergy is defined as an “abnormal immune reaction to an ordinarily harmless substance” [1], however Athe meaning of the word has taken many forms since its introduction in 1906 by Austrian Paediatrician and Immunologist, Clemens von Pirquet [2]. Combining his observations on the paediatric wards, where infectious diseases, vaccinations and diphtheria serum sickness were commonplace, and his knowledge of immune reactions in the laboratory, von Pirquet devised the term ‘allergy’, roughly translating as ‘different reaction’ in Greek. It grouped together illnesses such as asthma, hay fever and eczema, and placed them on the same spectrum as acquired immunity from vaccinations and reactions to therapeutic toxins. His conclusions were extrapolated by Charles Mantoux to develop his tuberculin test two years later. Unfortunately, this theory linking Clemens von Pirquet with a patient. Image courtesy of Wellcome Collection - https://wellcomecollection.org/works/yd78ffbn immunity and hypersensitivity, and von Piquet’s subsequent inference that antibodies could be both protective and also include morbidity – as governments References 1. AAAAI. The American Academy of Allergy, Asthma harmful, was dismissed by many of his peers, realised the economic cost of chronic illness. Allergy became a clinical specialty in its & Immunology. www.aaaai.org/conditions-and- who instead supported French Physiologist, treatments/conditions-dictionary/allergy Last Charles Richet. Richet’s work on reinjection own right, with dedicated clinics, journals accessed October 2020. of dogs with sea anemone toxins showed and professional organisations in the 2. Jackson M. Allergy, The History of a Modern Malady. that a small, second dose could induce a interwar years.