Evidence for Design in Physics and Biology: from the Origin of the Universe to the Origin of Life
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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Intelligent Design, Abiogenesis, and Learning from History: Dennis R
Author Exchange Intelligent Design, Abiogenesis, and Learning from History: Dennis R. Venema A Reply to Meyer Dennis R. Venema Weizsäcker’s book The World View of Physics is still keeping me very busy. It has again brought home to me quite clearly how wrong it is to use God as a stop-gap for the incompleteness of our knowledge. If in fact the frontiers of knowledge are being pushed back (and that is bound to be the case), then God is being pushed back with them, and is therefore continually in retreat. We are to find God in what we know, not in what we don’t know; God wants us to realize his presence, not in unsolved problems but in those that are solved. Dietrich Bonhoeffer1 am thankful for this opportunity to nature, is the result of intelligence. More- reply to Stephen Meyer’s criticisms over, this assertion is proffered as the I 2 of my review of his book Signature logical basis for inferring design for the in the Cell (hereafter Signature). Meyer’s origin of biological information: if infor- critiques of my review fall into two gen- mation only ever arises from intelli- eral categories. First, he claims I mistook gence, then the mere presence of Signature for an argument against bio- information demonstrates design. A few logical evolution, rendering several of examples from Signature make the point my arguments superfluous. Secondly, easily: Meyer asserts that I have failed to refute … historical scientists can show that his thesis by not providing a “causally a presently acting cause must have adequate alternative explanation” for the been present in the past because the origin of life in that the few relevant cri- proposed candidate is the only known tiques I do provide are “deeply flawed.” cause of the effect in question. -
And Abiogenesis
Historical Development of the Distinction between Bio- and Abiogenesis. Robert B. Sheldon NASA/MSFC/NSSTC, 320 Sparkman Dr, Huntsville, AL, USA ABSTRACT Early greek philosophers laid the philosophical foundations of the distinction between bio and abiogenesis, when they debated organic and non-organic explanations for natural phenomena. Plato and Aristotle gave organic, or purpose-driven explanations for physical phenomena, whereas the materialist school of Democritus and Epicurus gave non-organic, or materialist explanations. These competing schools have alternated in popularity through history, with the present era dominated by epicurean schools of thought. Present controversies concerning evidence for exobiology and biogenesis have many aspects which reflect this millennial debate. Therefore this paper traces a selected history of this debate with some modern, 20th century developments due to quantum mechanics. It ¯nishes with an application of quantum information theory to several exobiology debates. Keywords: Biogenesis, Abiogenesis, Aristotle, Epicurus, Materialism, Information Theory 1. INTRODUCTION & ANCIENT HISTORY 1.1. Plato and Aristotle Both Plato and Aristotle believed that purpose was an essential ingredient in any scienti¯c explanation, or teleology in philosophical nomenclature. Therefore all explanations, said Aristotle, answer four basic questions: what is it made of, what does it represent, who made it, and why was it made, which have the nomenclature material, formal, e±cient and ¯nal causes.1 This aristotelean framework shaped the terms of the scienti¯c enquiry, invisibly directing greek science for over 500 years. For example, \organic" or \¯nal" causes were often deemed su±cient to explain natural phenomena, so that a rock fell when released from rest because it \desired" its own kind, the earth, over unlike elements such as air, water or ¯re. -
Fine-Tuning, Complexity, and Life in the Multiverse*
Fine-Tuning, Complexity, and Life in the Multiverse* Mario Livio Dept. of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154, USA E-mail: [email protected] and Martin J. Rees Institute of Astronomy, University of Cambridge, Cambridge CB3 0HA, UK E-mail: [email protected] Abstract The physical processes that determine the properties of our everyday world, and of the wider cosmos, are determined by some key numbers: the ‘constants’ of micro-physics and the parameters that describe the expanding universe in which we have emerged. We identify various steps in the emergence of stars, planets and life that are dependent on these fundamental numbers, and explore how these steps might have been changed — or completely prevented — if the numbers were different. We then outline some cosmological models where physical reality is vastly more extensive than the ‘universe’ that astronomers observe (perhaps even involving many ‘big bangs’) — which could perhaps encompass domains governed by different physics. Although the concept of a multiverse is still speculative, we argue that attempts to determine whether it exists constitute a genuinely scientific endeavor. If we indeed inhabit a multiverse, then we may have to accept that there can be no explanation other than anthropic reasoning for some features our world. _______________________ *Chapter for the book Consolidation of Fine Tuning 1 Introduction At their fundamental level, phenomena in our universe can be described by certain laws—the so-called “laws of nature” — and by the values of some three dozen parameters (e.g., [1]). Those parameters specify such physical quantities as the coupling constants of the weak and strong interactions in the Standard Model of particle physics, and the dark energy density, the baryon mass per photon, and the spatial curvature in cosmology. -
Arguments from Design
Arguments from Design: A Self-defeating Strategy? Victoria S. Harrison University of Glasgow This is an archived version of ‘Arguments form Design: A Self-defeating Strategy?’, published in Philosophia 33 (2005): 297–317. Dr V. Harrison Department of Philosophy 69 Oakfield Avenue University of Glasgow Glasgow G12 8LT Scotland UK E-mail: [email protected] Arguments from Design: A Self-defeating Strategy? Abstract: In this article, after reviewing traditional arguments from design, I consider some more recent versions: the so-called ‘new design arguments’ for the existence of God. These arguments enjoy an apparent advantage over the traditional arguments from design by avoiding some of Hume’s famous criticisms. However, in seeking to render religion and science compatible, it seems that they require a modification not only of our scientific understanding but also of the traditional conception of God. Moreover, there is a key problem with arguments from design that Mill raised to which the new arguments seem no less vulnerable than the older versions. The view that science and religion are complementary has at least one significant advantage over other positions, such as the view that they are in an antagonistic relationship or the view that they are so incommensurable that they are neither complementary nor antagonistic. The advantage is that it aspires to provide a unified worldview that is sensitive to the claims of both science and religion. And surely, such a worldview, if available, would seem to be superior to one in which, say, scientific and religious claims were held despite their obvious contradictions. -
Five Great Ideas of Biology
GREATGREAT IDEASIDEAS OFOF BIOLOGYBIOLOGY Paul Nurse KITP Public Lecture, Feb 24, 2010 THETHE CELLCELL The basic unit of life ROBERTROBERT HOOKEHOOKE’’SS MICROSCOPEMICROSCOPE Cork Image: Past Present STEMSTEM IMAGES:IMAGES: PASTPAST ANDAND PRESENTPRESENT Nehemiah Grew (1682) ANTONIANTONI VANVAN LEEUWENHOEKLEEUWENHOEK MICROORGANISMSMICROORGANISMS VANVAN LEEUWENHOEK?LEEUWENHOEK? THEODORTHEODOR SCHWANNSCHWANN “We have seen that all organisms are composed of essentially like parts, namely, of cells.” (1839) RUDOLFRUDOLF VIRCHOWVIRCHOW “Every animal appears as a sum of vital units, each of which bears in itself the complete characteristics of life.” (1858) CELLCELL Rockefeller Nobel Prize Winners in Cell Biology George E. Palade (1974) Christian de Duve (1974) Albert Claude (1974) Günter Blobel (1999) MAMMALIANMAMMALIAN EMBRYOEMBRYO SPERMSPERM ANDAND EGGEGG THETHE CELLCELL The basic unit of life Underpins all reproduction and development Stem cells THETHE GENEGENE Basis of heredity GREGORGREGOR MENDELMENDEL MENDELMENDEL’’SS GARDENGARDEN PEASPEAS PEASPEAS 1919TH CENTURYCENTURY CHROMOSOMESCHROMOSOMES EDOUARDEDOUARD VANVAN BENEDENBENEDEN’’SS NEMATODENEMATODE CHROMOSOMESCHROMOSOMES PNEUMOCOCCUSPNEUMOCOCCUS Avery, MacLeod and McCarty, Rockefeller University (1944) DNADNA MOLECULEMOLECULE CENTRALCENTRAL DOGMADOGMA THETHE GENEGENE Basis of heredity Genotype to phenotype Implications for what we are EVOLUTIONEVOLUTION BYBY NATURALNATURAL SELECTIONSELECTION Life evolves Mechanism of natural selection ERASMUSERASMUS ANDAND CHARLESCHARLES DARWINDARWIN -
The Arrow of Time Volume 7 Paul Davies Summer 2014 Beyond Center for Fundamental Concepts in Science, Arizona State University, Journal Homepage P.O
The arrow of time Volume 7 Paul Davies Summer 2014 Beyond Center for Fundamental Concepts in Science, Arizona State University, journal homepage P.O. Box 871504, Tempe, AZ 852871504, USA. www.euresisjournal.org [email protected] Abstract The arrow of time is often conflated with the popular but hopelessly muddled concept of the “flow” or \passage" of time. I argue that the latter is at best an illusion with its roots in neuroscience, at worst a meaningless concept. However, what is beyond dispute is that physical states of the universe evolve in time with an objective and readily-observable directionality. The ultimate origin of this asymmetry in time, which is most famously captured by the second law of thermodynamics and the irreversible rise of entropy, rests with cosmology and the state of the universe at its origin. I trace the various physical processes that contribute to the growth of entropy, and conclude that gravitation holds the key to providing a comprehensive explanation of the elusive arrow. 1. Time's arrow versus the flow of time The subject of time's arrow is bedeviled by ambiguous or poor terminology and the con- flation of concepts. Therefore I shall begin my essay by carefully defining terms. First an uncontentious statement: the states of the physical universe are observed to be distributed asymmetrically with respect to the time dimension (see, for example, Refs. [1, 2, 3, 4]). A simple example is provided by an earthquake: the ground shakes and buildings fall down. We would not expect to see the reverse sequence, in which shaking ground results in the assembly of a building from a heap of rubble. -
Evidence for God
Evidence for God (part 1 of 8): Fine Tuning of Physical Laws of Universe What is Fine Tuning? Over the past century, scientists have discovered that if certain properties of the universe were changed very slightly from what they are, we would not be here. They have to be within a very narrow range for our universe to make life possible and be habitable. The universe is fine-tuned for the existence of intelligent life with a complexity and delicacy that literally defy human comprehension. The sensitivity of the „habitability‟ of the universe to small changes is called „fine-tuning.‟ This was recognized about 60 years ago by Fred Hoyle who was not a religious person at the time he made the discovery. Scientists like Paul Davies, Martin Rees, Max Tegmark, Bernard Carr, Frank Tipler, John Barrow, and Stephen Hawking, to name a few, believe in fine-tuning. These are prominent names in cosmology as they are heard in the media whenever a news headline is made. Types of Fine-Tuning 1. Fine tuning of the laws of nature. 2. Fine-tuning of the constants of physics. 3. Fine tuning of the initial conditions of the universe. We will explore each category below: 1. Fine tuning of the laws of nature There are two ways to look at this aspect of fine-tuning: 1. Precisely the right laws are needed for highly complex life to exist. If one of these were missing, such life would not be possible. To say that the laws are fine-tuned means that the universe must have precisely the right set of laws in order for highly complex life to exist. -
George Palade 1912-2008
George Palade, 1912-2008 Biography George Palade was born in November, 1912 in Jassy, Romania to an academic family. He graduated from the School of Medicine of the The Founding of Cell Biology University of Bucharest in 1940. His doctorial thesis, however, was on the microscopic anatomy of the cetacean delphinus Delphi. He The discipline of Cell Biology arose at Rockefeller University in the late practiced medicine in the second world war, and for a brief time af- 1940s and the 1950s, based on two complimentary techniques: cell frac- terwards before coming to the USA in 1946, where he met Albert tionation, pioneered by Albert Claude, George Palade, and Christian de Claude. Excited by the potential of the electron microscope, he Duve, and biological electron microscopy, pioneered by Keith Porter, joined the Rockefeller Institute for Medical Research, where he did Albert Claude, and George Palade. For the first time, it became possible his seminal work. He left Rockefeller in 1973 to chair the new De- to identify the components of the cell both structurally and biochemi- partment of Cell Biology at Yale, and then in 1990 he moved to the cally, and therefore begin understanding the functioning of cells on a University of California, San Diego as Dean for Scientific Affairs at molecular level. These individuals participated in establishing the Jour- the School of Medicine. He retired in 2001, at age 88. His first wife, nal of Cell Biology, (originally the Journal of Biochemical and Biophysi- Irina Malaxa, died in 1969, and in 1970 he married Marilyn Farquhar, cal Cytology), which later led, in 1960, to the organization of the Ameri- another prominent cell biologist, and his scientific collaborator. -
Intelligent Design Creationism and the Constitution
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Washington University St. Louis: Open Scholarship Washington University Law Review Volume 83 Issue 1 2005 Is It Science Yet?: Intelligent Design Creationism and the Constitution Matthew J. Brauer Princeton University Barbara Forrest Southeastern Louisiana University Steven G. Gey Florida State University Follow this and additional works at: https://openscholarship.wustl.edu/law_lawreview Part of the Constitutional Law Commons, Education Law Commons, First Amendment Commons, Religion Law Commons, and the Science and Technology Law Commons Recommended Citation Matthew J. Brauer, Barbara Forrest, and Steven G. Gey, Is It Science Yet?: Intelligent Design Creationism and the Constitution, 83 WASH. U. L. Q. 1 (2005). Available at: https://openscholarship.wustl.edu/law_lawreview/vol83/iss1/1 This Article is brought to you for free and open access by the Law School at Washington University Open Scholarship. It has been accepted for inclusion in Washington University Law Review by an authorized administrator of Washington University Open Scholarship. For more information, please contact [email protected]. Washington University Law Quarterly VOLUME 83 NUMBER 1 2005 IS IT SCIENCE YET?: INTELLIGENT DESIGN CREATIONISM AND THE CONSTITUTION MATTHEW J. BRAUER BARBARA FORREST STEVEN G. GEY* TABLE OF CONTENTS ABSTRACT ................................................................................................... 3 INTRODUCTION.................................................................................................. -
The Emergent, Self-Explaining Universe of Paul Davies – a Summary and Christian Response
S & CB (2012), 24, 33–53 0954–4194 PAUL HIMES The Emergent, Self-explaining Universe of Paul Davies – a Summary and christian Response Physicist Paul Davies has emerged as one of the most popular scientists of the twenty-first century, despite his critique of the scientific establishment and its perceived failure to account for the origins and rational nature of the universe. Davies argues that the scientific consensus on cosmology rests on faith, both in its failure to provide an ultimate explanation for the origin of the universe and in its blind acceptance of its rational laws. As an alternative, Davies postulates an ‘emergent’ universe which contains the cause of its own existence and which renders unnecessary any sort of a personal deity. Yet Davies’s alternative falls short of providing a satisfactory cosmic explanation. Davies himself cannot adequately account for the principle of backward causation which creates his universe, and thus his paradigm still relies on a transcendent principle that remains unexplained. Furthermore, Davies’s objections against a personal god can be answered on philosophical grounds. Thus Davies’s hypothesis does not provide a superior alternative to the Christian view of God. key words: Paul Davies, physics, universe, emergent, self-causation, quantum mechanics, cosmology, time, teleology, cosmological argument, fine-tuning introduction Douglas Adams’ classic Hitchhiker’s Guide to the Galaxy tells the story of an advanced civilisation that builds a magnificent supercomputer for the sole purpose of providing the ultimate answer to the meaning of ‘life, the universe, and everything’. After millions of years of calculation, the an- swer, much to the confusion and frustration of the advanced civilisation, turns out to be ‘42’.1 Physicist Paul C. -
Balcomk41251.Pdf (558.9Kb)
Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr.