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Cell Circuitry || Science Teaches English || The Chicken Genome Is Hot || Magnets in Medicine SEPTEMBER 2002 www.hhmi.org/bulletin Leading Doublea Life It’s a stretch, but doctors who work bench to bedside say they wouldn’t do it any other way. FEATURES 14 On Human Terms 24 The Evolutionary War A small—some say too small—group of Efforts to undermine evolution education have physician-scientists believes the best science evolved into a 21st-century marketing cam- requires patient contact. paign that relies on legal acumen, manipulation By Marlene Cimons of scientific literature and grassroots tactics. 20 Engineering the Cell By Trisha Gura Adam Arkin sees the cell as a mechanical system. He hopes to transform molecular 28 Call of the Wild biology into a kind of cellular engineering Could quirky, new animal models help scien- and in the process, learn how to move cells tists learn how to regenerate human limbs or from sickness to health. avert the debilitating effects of a stroke? By M. Mitchell Waldrop By Kathryn Brown 24 In front of a crowd of 1,500, Ohio’s Board of Education heard testimony on whether students should learn about intelligent design in science class. DEPARTMENTS 2 NOTA BENE 33 PERSPECTIVE ulletin Intelligent Design Is a Cop-Out 4 LETTERS September 2002 || Volume 15 Number 3 NEWS AND NOTES HHMI TRUSTEES PRESIDENT’S LETTER 5 JAMES A. BAKER, III, ESQ. 34 Senior Partner, Baker & Botts A Creative Influence In from the Fields ALEXANDER G. BEARN, M.D. Executive Officer, American Philosophical Society 35 Lost on the Tip of the Tongue Adjunct Professor, The Rockefeller University UP FRONT Professor Emeritus of Medicine, Cornell University Medical College 36 Biology by Numbers FRANK WILLIAM GAY 6 Follow the Songbird Former President and Chief Executive Officer, SUMMA Corporation JAMES H. -
BSCB Newsletter 2017D
2017 BSCB Newsletter BRITISH SOCIETY FOR CELL BIOLOGY Meet the new BSCB President Royal Opening of the Crick Meeting reports 2017 CONTENTS BSCB Newsletter News 2 Book reviews 7 Features 8 Meeting Reports 24 Summer students 30 Society Business 33 Editorial Welcome to the 2017 BSCB newsletter. After several meeting hosted several well received events for our Front cover: years of excellent service, Kate Nobes has stepped PhD and Postdoc members, which we discuss on The head of a Drosophila pupa. The developing down and handed the reins over to me. I’ve enjoyed page 5. Our PhD and Postdoc reps are working hard compound eye (green) is putting together this years’ newsletter. It’s been great to make the event bigger and better for next year! The composed of several hundred simple units called ommatidia to hear what our members have been up to, and I social events were well attended including the now arranged in an extremely hope you will enjoy reading it. infamous annual “Pub Quiz” and disco after the regular array. The giant conference dinner. Members will be relieved to know polyploidy cells of the fat body (red), the fly equivalent of the The 2016 BSCB/DB spring meeting, organised by our we aren’t including any photos from that here. mammalian liver and adipose committee members Buzz Baum (UCL), Silke tissue, occupy a big area of the Robatzek and Steve Royle, had a particular focus on In this issue, we highlight the great work the BSCB head. Cells and Tissue Architecture, Growth & Cell Division, has been doing to engage young scientists. -
Download Program Guide
2011 C. elegans Meeting Organizing Committee Co-chairs: Oliver Hobert Columbia University Meera Sundaram University of Pennsylvania Organizing Committee: Raffi Aroian University of California, San Diego Ikue Mori Nagoya University Jean-Louis Bessereau INSERM Benjamin Podbilewicz Technion Israel Institute of Keith Blackwell Harvard Medical School Technology Andrew Chisholm University of California, San Diego Valerie Reinke Yale University Barbara Conradt Dartmouth Medical School Janet Richmond University of Illinois, Chicago Marie Anne Felix CNRS-Institut Jacques Monod Ann Rougvie University of Minnesota David Greenstein University of Minnesota Shai Shaham Rockefeller University Alla Grishok Columbia University Ahna Skop University of Wisconsin, Madison Craig Hunter Harvard University Ralf Sommer Max-Planck Institute for Bill Kelly Emory University Developmental Biology, Tuebingen Ed Kipreos University of Georgia Asako Sugimoto RIKEN, Kobe Todd Lamitina University of Pennsylvania Heidi Tissenbaum University of Massachusetts Chris Li City College of New York Medical School Sponsored by The Genetics Society of America 9650 Rockville Pike, Bethesda, MD 20814-3998 telephone: (301) 634-7300 fax: (301) 634-7079 e-mail: [email protected] Web site: http:/www.genetics-gsa.org Front cover design courtesy of Ahna Skop 1 Table of Contents Schedule of All Events.....................................................................................................................4 Maps University of California, Los Angeles, Campus .....................................................................7 -
Section 1: MIT Facts and History
1 MIT Facts and History Economic Information 9 Technology Licensing Office 9 People 9 Students 10 Undergraduate Students 11 Graduate Students 12 Degrees 13 Alumni 13 Postdoctoral Appointments 14 Faculty and Staff 15 Awards and Honors of Current Faculty and Staff 16 Awards Highlights 17 Fields of Study 18 Research Laboratories, Centers, and Programs 19 Academic and Research Affiliations 20 Education Highlights 23 Research Highlights 26 7 MIT Facts and History The Massachusetts Institute of Technology is one nologies for artificial limbs, and the magnetic core of the world’s preeminent research universities, memory that enabled the development of digital dedicated to advancing knowledge and educating computers. Exciting areas of research and education students in science, technology, and other areas of today include neuroscience and the study of the scholarship that will best serve the nation and the brain and mind, bioengineering, energy, the envi- world. It is known for rigorous academic programs, ronment and sustainable development, informa- cutting-edge research, a diverse campus commu- tion sciences and technology, new media, financial nity, and its long-standing commitment to working technology, and entrepreneurship. with the public and private sectors to bring new knowledge to bear on the world’s great challenges. University research is one of the mainsprings of growth in an economy that is increasingly defined William Barton Rogers, the Institute’s founding pres- by technology. A study released in February 2009 ident, believed that education should be both broad by the Kauffman Foundation estimates that MIT and useful, enabling students to participate in “the graduates had founded 25,800 active companies. -
Sten Grillner
BK-SFN-HON_V9-160105-Grillner.indd 108 5/6/2016 4:11:20 PM Sten Grillner BORN: Stockholm, Sweden June 14, 1941 EDUCATION: University of Göteborg, Sweden, Med. Candidate (1962) University of Göteborg, Sweden, Dr. of Medicine, PhD (1969) Academy of Science, Moscow, Visiting Scientist (1971) APPOINTMENTS: Docent in Physiology, Medical Faculty, University of Göteborg (1969–1975) Professor, Department of Physiology III, Karolinska Institute (1975–1986) Director, Nobel Institute for Neurophysiology, Karolinska Institute, Professor (1987) Nobel Committee for Physiology or Medicine, Chair, 1995–1997 (1987–1998) Nobel Assembly at the Karolinska Institutet, Member Chair, 2005 (1988–2008) Chairman Department of Neuroscience, Karolinska Institutet (1993–2000) Distinguished Professor, Karolinska Institutet (2010) HONORS AND AWARDS: Member of Academiae Europaea 1990– Member of Royal Swedish Academy of Science 1993– Chairman Section for Biology and Member of Academy Board, 2004–2010 Member of Norwegian Academy of Science and Letters, 1997– Member American Academy of Arts and Sciences, 2004– Honorary Member of the Spanish Medical Academy, 2006– Foreign Associate of Institute of Medicine of the National Academy, United States, 2006– Foreign Associate of the National Academy, United States, 2010– Associate of the Neuroscience Institute, La Jolla, 1989– Member EMBO, 2014– Florman Award, Royal Swedish Academy of Science, 1977 Grass Lecturer to the Society of Neuroscience, Boston, 1983 Greater Nordic Prize of Eric Fernstrom, Lund, Sweden, 1990 Bristol-Myers -
Exploring Nsr100/SRRM4 As a Therapeutic Target for Autism Spectrum Disorder in Mice
Exploring nSR100/SRRM4 as a therapeutic target for autism spectrum disorder in mice by Juli Wang A thesis submitted in conformity with the requirements for the degree of Master of Science Department of Molecular Genetics University of Toronto © Copyright by Juli Wang, 2019 I Exploring nSR100/SRRM4 as a Therapeutic Target for ASD in Mice Juli Wang Master of Science Department of Molecular Genetics University of Toronto 2019 Abstract Misregulation of nSR100 and its target microexons are common in a large proportion of ASD patients and cause ASD-associated features in mice. This thesis explores nSR100 and its target splicing program as a potential therapeutic target using a conditional knockout allele, nSR100GT. I show that nSR100 protein is effectively depleted in the cortical regions of nSR100GT mutant mice at E17.5, E18.5, and P2 stages, which correlates with phenotypes overlapping with all core behavioral domains of ASD. I show that tamoxifen-mediated rescue in prenatal nSR100GT animals restores nSR100 protein and microexon inclusion levels comparable to those observed in wildtype mice. Collectively my thesis research shows that the nSR100GT mouse strain holds the promise for examining phenotypic effects of nSR100 reactivation in ASD-like mice at different developmental stages, and complimentary models are also to be considered for investigating the therapeutic potential of targeting nSR100 in the context of ASD. II Acknowledgments I wholeheartedly thank for the tremendous support and educational experiences I have received from my mentors, -
Awards and Honours: April 2019
AWARDS AND HONOURS: APRIL 2019 Name Category Organized/ Presented by PM Narendra Modi Russian Award “Order of Saint Russia Andrew The Apostle” Dr Babasaheb Ambedkar Nobel International Human Rights Sunny Shah(Founder of International Council Award Human Rights Council) K Siva Reddy Prestigious Saraswati Samman KK Birla Foundation 2018 Dr. A K Singh Lifetime Achievement Award University to mark World Creativity and Innovation Day Bhayanakam (Malayalam film) Best Cinematography Award Beijing International Film Festival Benny Antony National Intellectual Property Intellectual Property Office India and Award for 2019. the World Intellectual Property Organisation (WIPO) Author Rana Dasgupta Rabindranath Tagore Literary -- Prize 2019 All India Radio and Children's Film Swacchta Pakhwada Award Secretary in the Information and Society of India. Broadcasting Ministry Amit Khare Dr Rajendra Joshi Pravasi Bhartiya Samman Award Indian Ambassador to Switzerland Sibi George Lewis Hamilton Bahrain Grand Prix 2019 title Bahrain Grand Prix Vikram Patel John Dirks Canada Gairdner -- Global Health Award. PM Narendra Modi Zayed Medal President of the UAE Sheikh Khalifa bin Zayed Al Nahyan Shah Rukh Khan Honorary doctorate in University of Law, London Philanthropy Dr Sohini Sastri 'D. Litt in Astrology' Award National American University, USA. Tata Steel 'Global Slag Company of the Germany Year' Award Jacques Kallis Order of Ikhamanga in the Silver President of South Africa Division Deepa Malik New Zealand Prime Minister’s Sir New Zealand Edmund Hillary Fellowship for 2019 'Dost Education' $25,000 Next Billion Edtech Prize UK-based Varkey Foundation 2019 National Mission for Clean ‘Public Water Agency of the Year’ Global Water Intelligence at the Global www.BankExamsToday.com Page 1 Ganga(NMCG) or Namami Gange award Water Summit in London. -
GSA Welcomes 2012 Board Members
7INTERs3PRING 4HE'3!2EPORTER winter s spring 2012 New Executive GSA Welcomes 2012 Board Members Director Now on Board The Genetics Society of America New Members of the GSA Board of welcomes four new members elected Directors Adam P. Fagen, by the general membership to the Ph.D., stepped in as 2012 GSA Board of Directors. The VICE PRESIDENT: GSA’s new Executive new members are: Michael Lynch Michael Lynch, Director beginning (Indiana University), who serves as Distinguished December 1, 2011. vice president in 2012 and as GSA Professor of Dr. Fagen previously president in 2013 and Marnie E. Biology, Class of was at the American Halpern (Carnegie Institution for 1954 Professor, Society of Plant Science); Mohamed Noor (Duke Department of Biologists (ASPB), University); and John Schimenti Biology, Indiana where he was the director of public (Cornell University), who will serve as University, continued on page nineteen directors. Bloomington. Dr. Lynch is a population and evolutionary biologist and a In addition to these elected officers, long-time member of GSA. Dr. Lynch 2012 Brenda J. Andrews (University of sees GSA as the home for geneticists Toronto), Editor-in-Chief of GSA’s who study a broad base of topics GSA Award journal, G3: Genes|Genomes|Genetics, and organisms, and as a forum Recipients which was first published online in where general discussion occurs, June 2011, becomes a member of the whether based on the principles Announced Board of Directors. The bylaws have of genetics, the most pressing historically included the GENETICS GSA is pleased to announce the issues within the discipline itself, or editor-in-chief on the Board and as a responses to societal concerns and/ 2012 recipients of its five awards result of a 2011 bylaw revision, the G3 for distinguished service in the or conflicts within applied genetics. -
Roles for Ca Mobilization and Its Regulation in Mast Cell Functions
REVIEW ARTICLE published: 08 May 2012 doi: 10.3389/fimmu.2012.00104 Roles for Ca2+ mobilization and its regulation in mast cell functions David Holowka*, Nathaniel Calloway , Roy Cohen, Deepti Gadi, Jinmin Lee, Norah L. Smith and Barbara Baird Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA Edited by: Mobilization of Ca2+ in response to IgE receptor-mediated signaling is a key process in Toshiaki Kawakami, La Jolla Institute many aspects of mast cell function. Here we summarize our current understanding of the for Allergy and Immunology, USA molecular bases for this process and the roles that it plays in physiologically relevant mast Reviewed by: Alasdair Gilfillan, National Institutes of cell biology. Activation of IgE receptor signaling by antigen that crosslinks these complexes 2+ 2+ Health, USA initiates Ca mobilization as a fast wave that is frequently followed by a series of Ca John Ryan, Virginia Commonwealth oscillations which are dependent on Ca2+ influx-mediated by coupling of the endoplasmic University, USA reticulum luminal Ca2+ sensor STIM1 to the calcium release activated calcium channel Anant Parekh, Oxford University, UK protein Orai1. Granule exocytosis depends on this process, together with the activation *Correspondence: David Holowka, Baker Laboratory, of protein kinase C isoforms, and specific roles for these signaling steps are beginning 2+ Department of Chemistry and to be understood. Ca mobilization also plays important roles in stimulated exocytosis Chemical Biology, Cornell University, of recycling endosomes and newly synthesized cytokines, as well as in antigen-mediated Ithaca, NY 14853-1301, USA. chemotaxis of rat mucosal mast cells. Phosphoinositide metabolism plays key roles in all e-mail: [email protected] of these processes, and we highlight these roles in several cases. -
Flow and Enzyme Biology
2010 ANNUAL MEETING THEMATIC MEETING SERIES BEGINS! July 2009 Stopped- Flow and Enzyme Biology American Society for Biochemistry and Molecular Biology contents JULY 2009 On the Cover: Britton Chance has provided innumerable contributions society news to the fields of biochemistry, 3 President’s Message biophysics, and biomedicine, including his design of 6 Washington Update the first stopped-flow 8 NIH News apparatuses (pictured). 32 special interest 18 The Department of Biological Chemistry at Johns Hopkins School of Medicine: 100 years at 100 Years of Excellence the Johns Hopkins 21 Honoring the Biochemist’s Biochemist: School of NIH Hosts the Stadtman Symposium Medicine. 18 2010 asbmb meeting 12 Lipids, Physiology, and Disease 14 Dealing with Insults: Genome Stability in the Face of Stress 16 Insights into the Biological Chemistry of RNA science focus 32 Britton Chance: Former Polymerase II: Olympian and Pioneer in Now Twice as Enzyme Kinetics and Faithful. Functional Spectroscopy 30 departments 2 Letters to the Editor 7 News from the Hill 10 Member Spotlight 22 Lipid News 23 Education and Training 26 Minority Affairs 28 Career Insights 30 BioBits podcast summary Listen to the latest JBC podcast featuring resources interviews with authors from the Thematic Scientific Meeting Calendar Minireview Series, “The biochemical basis for triplet repeat neurodegenerative diseases.” online only To hear this and other podcasts, go to www.asbmb.org/Interactive.aspx. July 2009 ASBMB Today 1 letters to the editor A monthly publication of The American Society for Biochemistry and Molecular Biology History Repeats Itself Officers Gregory A. Petsko President Heidi E. Hamm Past President in Big Pharma Mark A. -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
Local Costs of Conservation Exceed Those Borne by the Global Majority
This is a repository copy of Local costs of conservation exceed those borne by the global majority. White Rose Research Online URL for this paper: https://eprints.whiterose.ac.uk/129794/ Version: Published Version Article: Green, Jonathan Michael Halsey orcid.org/0000-0002-5003-0203, Fisher, Brendan, Green, Rhys E. et al. (6 more authors) (2018) Local costs of conservation exceed those borne by the global majority. Global Ecology and Conservation. e00385. pp. 1-10. ISSN 2351-9894 https://doi.org/10.1016/j.gecco.2018.e00385 Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/ Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ Global Ecology and Conservation 14 (2018) e00385 Contents lists available at ScienceDirect Global Ecology and Conservation journal homepage: http://www.elsevier.com/locate/gecco Original Research Article Local costs of conservation exceed those borne by the global majority Jonathan M.H. Green a, b, *, Brendan Fisher c, Rhys E. Green a, d, Joseph Makero e, Philip J.