IST Annual Report 2019
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ANNUAL REPORT 2010 Contents
ANNUAL REPORT 2010 Contents I. Overviews ...............................................................................................................3 Year 2010 in review, Director of FIMM ............................................................................. 3 Views from the former and current Chair of the Board ...................................................5 II. FIMM Launch Event ................................................................................................ 6 III. How is the Nordic EMBL Partnership build-up progressing in Oslo and Umeå? ..........7 IV. Academician of Science, Professor Leena Peltonen-Palotie in memoriam .............. 8 V. Research ................................................................................................................ 10 Human Genomics ..........................................................................................................10 Medical Systems Biology and Translational Research ..................................................... 14 Research collaborations and highlights ..........................................................................21 Personalized medicine of cancer becoming a reality.......................................................25 Doctoral Training ...........................................................................................................26 VI. Technology Centre .................................................................................................28 Genomics Unit ..............................................................................................................28 -
GSA Welcomes 2012 Board Members
7INTERs3PRING 4HE'3!2EPORTER winter s spring 2012 New Executive GSA Welcomes 2012 Board Members Director Now on Board The Genetics Society of America New Members of the GSA Board of welcomes four new members elected Directors Adam P. Fagen, by the general membership to the Ph.D., stepped in as 2012 GSA Board of Directors. The VICE PRESIDENT: GSA’s new Executive new members are: Michael Lynch Michael Lynch, Director beginning (Indiana University), who serves as Distinguished December 1, 2011. vice president in 2012 and as GSA Professor of Dr. Fagen previously president in 2013 and Marnie E. Biology, Class of was at the American Halpern (Carnegie Institution for 1954 Professor, Society of Plant Science); Mohamed Noor (Duke Department of Biologists (ASPB), University); and John Schimenti Biology, Indiana where he was the director of public (Cornell University), who will serve as University, continued on page nineteen directors. Bloomington. Dr. Lynch is a population and evolutionary biologist and a In addition to these elected officers, long-time member of GSA. Dr. Lynch 2012 Brenda J. Andrews (University of sees GSA as the home for geneticists Toronto), Editor-in-Chief of GSA’s who study a broad base of topics GSA Award journal, G3: Genes|Genomes|Genetics, and organisms, and as a forum Recipients which was first published online in where general discussion occurs, June 2011, becomes a member of the whether based on the principles Announced Board of Directors. The bylaws have of genetics, the most pressing historically included the GENETICS GSA is pleased to announce the issues within the discipline itself, or editor-in-chief on the Board and as a responses to societal concerns and/ 2012 recipients of its five awards result of a 2011 bylaw revision, the G3 for distinguished service in the or conflicts within applied genetics. -
The David H. Koch Institute for Integrative Cancer Research at MIT
The David H. Koch Institute for Integrative Cancer Research at MIT The David H. Koch Institute for Integrative Cancer Research was announced on October 9, 2007. By combining the faculty of the (now former) MIT Center for Cancer Research (CCR) with an equivalent number of distinguished engineers drawn from various MIT departments, the Koch Institute will continue CCR’s tradition of scientific excellence while also seeking to directly promote innovative ways to diagnose, monitor, and treat cancer through advanced technology. Among the engineering faculty there will be remarkable diversity, as the Electrical Engineering and Computer Science, Materials Science and Engineering, Biological Engineering, Chemical Engineering, and Mechanical Engineering departments will be represented in the Koch Institute. For three decades, CCR has been a mainstay of MIT’s—and the nation’s—efforts to conquer cancer. Its faculty has included five Nobel Prize winners, and the wealth of fundamental discoveries that have emerged under its aegis have helped shape the face of molecular biology. Under the banner of the Koch Institute, the future promises to hold even more astounding advances. Within the Koch Institute we will not directly provide clinical care for cancer patients but discoveries made by Koch Institute scientists and engineers will have a broad impact on how the disease is detected and managed. Applying our great strengths in science and technology, and working closely with our clinical collaborators, Koch Institute researchers will be tireless in unraveling the complexities of this disease and bringing new discoveries—and new hope—to patients. The Koch Institute includes more than 40 laboratories and more than 500 researchers located at our headquarters and across the MIT campus. -
2019 Annual Report 2019 Annual Report Society for Science & the Public
For more information, please contact: NEW FRONTIERS Bruce Makous Chief Advancement Officer 202-872-5138 | [email protected] www.societyforscience.org | www.sciencenews.org 2019 ANNUAL REPORT 2019 ANNUAL REPORT SOCIETY FOR SCIENCE & THE PUBLIC SCIENCE NEWS | MARCH 2, 2019 To create new elements and study the chemistry of the periodic table’s heaviest atoms, researchers at the Letter from Mary Sue Coleman, Chair 2 GSI Helmholtz Center for Heavy Ion Research in Darmstadt, Germany, Letter from Maya Ajmera, President & CEO 4 use the apparatus shown below to create beams of ions that scientists then smash into other elements. Society Top Moments of 2019 6 GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH/JAN Competitions 8 MICHAEL HOSAN 2018 Regeneron Science Talent Search 10 Intel International Science and Engineering Fair 12 Broadcom MASTERS 14 Alumni 16 Science News Media Group 18 Science News 20 SN 10 22 Science News for Students 24 Outreach & Equity 26 Science News in High Schools 28 Advocate Program 30 Research Teachers Conferences 32 STEM Research Grants 34 STEM Action Grants 36 Financials 38 SCIENCE NEWS FOR STUDENTS | JUNE 6, 2019 New ISEF Sponsorship Model 40 ”Grid,” by math artist Henry Segerman, explores mathematical Giving 42 concepts using projections. This 3D-printed sculpture is a patterned Leadership 52 sphere. When light shines through the openings from above, the shadows form a square grid. Executive Team & Staff 55 H. SEGERMAN SCIENCE NEWS | MARCH 30, 2019 Maybe only 30 out of 1,000 icebergs have a green hue, earning them the nickname “jade bergs.” Now scientists may know why the ice has this unusual color. -
Trouble with Testosterone Test
Trouble with testosterone test Annual Meeting Special Section CONTENTS NEWS FEATURES PERSPECTIVES 2 14 36 EDITOR’S NOTE THE TROUBLE WITH PUBLIC AFFAIRS It’s time THE TESTOSTERONE TEST Are postdocs still invisible? 3 18 38 PRESIDENT’S MESSAGE MASTERS OF PHYSIOLOGY MINORITY AFFAIRS Celebrating serendipity 38 Exemplifying Sewer’s commitment to diversity 22 40 Diversifying the scientic 4 THE 2017 ANNUAL MEETING NEWS FROM THE HILL workforce with IMAGE 23 Expand your scientic horizons A lot at stake 42 Cultivating a focus on diversity 29 e spotlight is on you as a community 30 Promoting lifelong learning 5 34 Advance your careers, grad students MEMBER UPDATE 44 and postdocs! TRANSITIONS 35 Reminders for the 2017 ASBMB 7 Undergraduate Poster Competition Wrestling with life RETROSPECTIVE 7 Roscoe Owen Brady (1923–2016) 14 48 9 Roger Tsien (1952–2016) Experts are OPEN CHANNELS grappling with what constitutes 10 high testosterone 42 blood levels in elite NEWS track and eld Blind wins Tabor award women athletes. for work on nuclear lipids 11 JOURNAL NEWS 11 Blocking potato blight’s ability 22 to set up shop 12 Infant gut microbes’ thirst for milk proteins 13 How a single-cell marine organism makes fatty acids 12 44 TRANSITION STATES NOVEMBER 2016 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s time By Angela Hopp OFFICERS COUNCIL MEMBERS Natalie Ahn Squire J. Booker President Victoria J. DeRose Wayne Fairbrother. recently saw a documen- Ben Corb, in his “News Steven McKnight Karen G. Fleming tary on Netix about from the Hill” column, Past President Rachel Green uncontacted tribes in writes about the count- Jennifer DuBois Susan Marqusee I Secretary Jared Rutter the rainforest on the border down to a new American Celia A. -
SCHEDULE of EVENTS Saturday, April 5 ALL SESSIONS ELIGIBLE for CME CREDIT UNLESS OTHERWISE NOTED.*
09_14AM_SchedEvents_Layout 1 3/11/14 12:29 PM Page 101 SCHEDULE OF EVENTS Saturday, April 5 ALL SESSIONS ELIGIBLE FOR CME CREDIT UNLESS OTHERWISE NOTED.* Saturday, April 5, 2014 Integrative Molecular Epidemiology , Thomas A. Sellers, Chairperson, Room 25, San Diego Convention Center, p. 146 8:00 a.m.-10:00 a.m. Educational Sessions Speakers: Thomas A. Sellers, Lorelei A. Mucci, Simon A. Gayther, Peter Kraft Beyond Ipilimumab and PD1/PD-L1 Pathway Blockade: Next Generation of Immunomodulatory PI3K-mTOR/PTEN , Ramon E. Parsons, Chairperson, Antibodies , Mario Sznol, Chairperson, Room 33, Room 31, San Diego Convention Center, p. 146 San Diego Convention Center, p. 143 Speakers: Lewis C. Cantley, Bart Vanhaesebroeck, John Speakers: Mario Sznol, Ana C. Anderson, Drew M. Blenis, Ramon E. Parsons Pardoll, Andrew D. Weinberg Targeting RhoGTPases and Their Kinase Effectors , Cancer Metabolism , Chi V. Dang, Chairperson, Jonathan Chernoff, Chairperson, Room 1, San Diego Room 6CF, San Diego Convention Center, p. 143 Convention Center, p. 146 Speakers: Chi V. Dang, Joshua D. Rabinowitz, Matthew Speakers: Jonathan Chernoff, Nupam P. Mahajan, G. Vander Heiden, Teresa W. M. Fan Cristina Fernandez-Valle, Michael F. Olson Drugging the Cell Cycle in Cancer , Geoffrey I. Shapiro, Tumor Immunology and Immunotherapy for Non- Chairperson, Room 7, San Diego Convention Center, Immunologists , Michael A. Caligiuri, Chairperson, p. 144 Ballroom 20D, San Diego Convention Center, p. 147 Speakers: Geoffrey I. Shapiro, David D. L. Bowtell, Alan Speakers: Robert A. Baiocchi, Lisa M. Coussens, Jeffrey Eastman, Wenyi Wei A. Sosman, Crystal L. Mackall Evolving Tumor Cell Populations: Dealing with Diversity , Nicholas E. Navin, Chairperson, Room 11, San Diego Convention Center, p. -
Education Issue
ascb august 2018 | vol. 41 | no. 4 NEWSsecond order promotingLETTER scholarly developingascb election science 7 change in 14 evaluation of teaching 1721 educatorsresults one best higher education practice at a time education issue five ways to get scientific about learning and teaching Call for Papers Fifth Special Issue on Quantitative Cell Biology Image by Hafuy Wolfenson, courtesy of Michael Sheetz Issue Co-Editors: Diane Lidke, Submit by: Oct. 15 • Release Date: Spring 2019 • Jennifer Lippincott-Schwartz, and Alex Mogilner About the issue: ASCB and Molecular Biology of the Cell (MBoC) recognize the profound influence that concepts and technologies from the physical and computational sciences are having on cell biology. This issue will build on the great success of the first four issues, published in 2014, 2015, 2016, and 2017, and will provide an opportunity for researchers whose work crosses disciplines to reach a wide audience. MBoC invites you to submit your best research articles, including methods papers, in the following areas: Quantitative imaging • Superresolution imaging techniques and their applications • Single- molecule biology • Biophysical properties of cells and cell structures • Computational and mathematical modeling • Systems studies of cell signaling and complex physiological processes • Innovative physical or computational approaches to cell biological problems • Big data methods and applications MBoC offers fair, constructive, and rapid peer review. It is your journal for the best in cell biology research. ASCB members receive a 20% discount on article publication charges. Stop waiting. Start publishing. /ascbiology Questions? Please contact Editor-in-Chief David Drubin at [email protected] or visit molbiolcell.org. @ascbiology Submit your paper today at www.mbcpapers.org molbiolcell.org contents august 2018 | vol. -
A Role for the M9 Transport Signal of Hnrnp A1 in Mrna Nuclear Export Elisa Izaurralde,* Artur Jarmolowski,* Christina Beisel,* Iain W
A Role for the M9 Transport Signal of hnRNP A1 in mRNA Nuclear Export Elisa Izaurralde,* Artur Jarmolowski,* Christina Beisel,* Iain W. Mattaj,* Gideon Dreyfuss,‡ and Utz Fischer‡ *European Molecular Biology Laboratory, D-69117 Heidelberg, Germany; and ‡Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Pennsylvania 19104-6148 Abstract. Among the nuclear proteins associated with snRNPs or proteins carrying a classical basic NLS. Pre- mRNAs before their export to the cytoplasm are the vious work demonstrated the existence of nuclear ex- abundant heterogeneous nuclear (hn) RNPs. Several of port factors specific for particular classes of RNA. In- these contain the M9 signal that, in the case of hnRNP jection of hnRNP A1 but not of a mutant protein A1, has been shown to be sufficient to signal both nu- lacking the M9 domain inhibited export of mRNA but clear export and nuclear import in cultured somatic not of other classes of RNA. This suggests that hnRNP cells. Kinetic competition experiments are used here to A1 or other proteins containing an M9 domain play a demonstrate that M9-directed nuclear import in Xeno- role in mRNA export from the nucleus. However, the pus oocytes is a saturable process. Saturating levels of requirement for M9 function in mRNA export is not M9 have, however, no effect on the import of either U identical to that in hnRNP A1 protein transport. he transport of macromolecules between the nu- function named variously pp15, p10, or NTF2 (Moore and cleus and cytoplasm is a bi-directional process. -
Research at a Glance 2012
European Molecular Biology Laboratory Research at a Glance 2012 European Molecular Biology Laboratory Research at a Glance 2012 www.embl.org Research at a Glance 2012 Contents Introduction 6 About EMBL 8 Career opportunities 10 EMBL Heidelberg, Germany Directors’ Research 12 Cell Biology and Biophysics Unit 18 Developmental Biology Unit 32 Genome Biology Unit 42 Structural and Computational Biology Unit 52 Core Facilities 66 EMBL-EBI, Hinxton, United Kingdom European Bioinformatics Institute 76 Bioinformatics Services 90 EMBL Grenoble, France Structural Biology 98 EMBL Hamburg, Germany Structural Biology 110 EMBL Monterotondo, Italy Mouse Biology 120 Index 130 | Research at a Glance 2012 | 5 “EMBL combines a critical mass of expertise and resources with organisational exibility, enabling us to keep pace with today’s biology.” – Iain Mattaj 6 | Research at a Glance 2012 | e vision of the nations which founded the European Molecular Biology Laboratory was to create a centre of excellence where Europe’s best brains would come together to conduct basic research in molecular biology and related elds. During the intervening decades, EMBL has grown and developed substantially, and its member states now number twenty-one, including the rst associate member state, Australia. Over the years, EMBL has become the agship of European molecular biology and has been continuously ranked as one of the top research institutes worldwide. EMBL is Europe’s only intergovernmental laboratory in the life sciences and as such its missions extend beyond performing cutting-edge research in molecular biology. It also oers services to Euro- pean scientists, most notably in the areas of bioinformatics and structural biology, provides advanced training to researchers at all levels, develops new technologies and instrumentation, and actively engages in technology transfer for the benet of scientists and society. -
Weighing International Academic Awards
1896 1920 1987 2006 Weighing International Academic Awards Center for World-Class Universities Shanghai Jiao Tong University Shanghai, China January 20, 2015 Outline Introduction Methodology Results Introduction Backgrounds • Awards are prevalent in all societies and at all times as societal symbols of recognition. Even in the rational academic world, there is an elaborate and extensive system of awards. (Frey, 2006) • Numerous academic awards have been established to provide incentives and motivation for new academic work and to reward for past excellent academic accomplishment to individuals. Introduction Backgrounds • Academic awards, especially prestigious international academic awards, have played important roles in seeking excellence by assessing and ranking academic institutions, such as Shanghai Ranking, U.S. National Research Council (NRC)’s Assessment of Research-Doctorate Programs. • However, little is known about the reputations of academic awards. Introduction Research purposes • To establish a comprehensive and balanced list of international academic awards. • To weigh their relative reputations in relation to one another. Introduction International academic awards • Awards are granted to individuals who have made highly recognized academic contribution. • Awards are granted without restrictions on nationality, and generally regardless of race, gender, age, religion, ethnicity, disability, language, or political affiliation. • Awards included can generally be regarded as research awards. Some types of awards not included -
Spliceosomal Usnrnp Biogenesis, Structure and Function Cindy L Will* and Reinhard Lührmann†
290 Spliceosomal UsnRNP biogenesis, structure and function Cindy L Will* and Reinhard Lührmann† Significant advances have been made in elucidating the for each of the two reaction steps. Components of the biogenesis pathway and three-dimensional structure of the UsnRNPs also appear to catalyze the two transesterifi- UsnRNPs, the building blocks of the spliceosome. U2 and cation reactions leading to excision of the intron and U4/U6•U5 tri-snRNPs functionally associate with the pre-mRNA ligation of the 5′ and 3′ exons. Here we describe recent at an earlier stage of spliceosome assembly than previously advances in our understanding of snRNP biogenesis, thought, and additional evidence supporting UsnRNA-mediated structure and function, focusing primarily on the major catalysis of pre-mRNA splicing has been presented. spliceosomal UsnRNPs from higher eukaryotes. Addresses Identification of a novel UsnRNA export factor Max Planck Institute of Biophysical Chemistry, Department of Cellular UsnRNP biogenesis is a complex process, many aspects of Biochemistry, Am Fassberg 11, 37077 Göttingen, Germany. which remain poorly understood. Although less is known *e-mail: [email protected] about the maturation process of the minor U11, U12 and †e-mail: [email protected] U4atac UsnRNPs, it is assumed that they follow a pathway Current Opinion in Cell Biology 2001, 13:290–301 similar to that described below for the major UsnRNPs 0955-0674/01/$ — see front matter (see Figure 1). The UsnRNAs, with the exception of U6 © 2001 Elsevier Science Ltd. All rights reserved. and U6atac (see below), are transcribed by RNA polymerase II as snRNA precursors that contain additional Abbreviations ′ CBC cap-binding complex 3 nucleotides and acquire a monomethylated, m7GpppG NLS nuclear localization signal (m7G) cap structure. -
Curriculum Vitae Professor Dr. Iain W. Mattaj
Curriculum Vitae Professor Dr. Iain W. Mattaj Name: Iain William Mattaj Born: 5 October 1952 Academic and Professional Career since 2005 Director General, European Molecular Biology Laboratory (EMBL) 1999 ‐ 2005 Scientific Director, European Molecular Biology Laboratory (EMBL) 1990 ‐ 2005 Programme Coordinator, Gene Expression Programme (EMBL) 1985 ‐ 1990 Group Leader at EMBL 1982 – 1985 Postdoctoral Research at the Biocenter, University of Basel with Dr. Eddy De Robertis 1979 ‐ 1982 Postdoctoral research at the Friedrich‐Miescher‐Institute, Basel, with Dr. Jean‐Pierre Jost 1978 ‐ 1979 Postdoctoral research at the University of Leeds, Dept. of Genetics, UK 1974 ‐ 1978 Postgraduate studies at the University of Leeds, Dept. of Genetics, UK with Dr. John Wootton 1970 ‐ 1974 Undergraduate studies at the University of Edinburgh, Scotland Functions in Scientific Societies and Committees 2010 ‐ 2011 FET (Future and Emerging Technologies) Flagships Science Coordination Group, Brussels since 2010 EMBO Scientific Publications Advisory Board 2009 ‐ 2010 Chair of the European Intergovernmental Scientific Research Organisation forum (EIROforum) since 2008 Chair of the Scientific Advisory Board of the DKFZ – ZMBH Alliance Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 1 since 2008 Chair of the Advisory Board for the Wellcome Trust Centre for Gene Regulation and Expression, Dundee, Scotland 2007 ‐ 2010 Member of the Scientific Planning Committee, UK‐Centre for Medical Research and Innovation since 2007 Member, and from 2010 Chair,