DOCSLIB.ORG

Cold Spring Harbor Laboratory 2016 Meetings & Courses

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Cold Spring Harbor Laboratory 2016 Meetings & Courses Cold Spring Harbor Laboratory 2016 Meetings & Courses Meetings Gene Expression & Signaling in the Glia in Health & Disease Axon Guidance, Synapse Formation & Regeneration Immune System July 21 - 25 abstracts due May 6 September 20 - 24 abstracts due July 1 Marc Freeman, Kelly Monk Greg Bashaw, Linda Richards, Peter Scheiffele Systems Biology: Global Regulation of April 26 - 30 abstracts due February 5 Gene Expression Diane Mathis, Stephen Nutt, Alexander Rudensky, Art Weiss Genome Engineering: The CRISPR/Cas Revolution August 17 - 20 abstracts due May 27 Mechanisms of Aging March 15 - 19 abstracts due January 8 September 26 - 30 abstracts due July 25 Nuclear Organization & Function Jennifer Doudna, Maria Jasin, Jonathan Weissman Barak Cohen, Christina Leslie, John Stamatoyannopoulos, Sarah Teichmann Vera Gorbunova, Malene Hansen, Scott Pletcher May 3 - 7 abstracts due February 12 Evolutionary Biology of Caenorhabditis & Edith Heard, Martin Hetzer, David Spector Regulatory & Non-Coding RNAs August 23 - 27 abstracts due June 3 Germ Cells October 4 - 8 abstracts due July 15 Other Nematodes The Biology of Genomes Victor Ambros, Elisa Izaurralde, Nicholas Proudfoot Robert Braun, Geraldine Seydoux March 30 - April 2 abstracts due January 15 May 10 - 14 abstracts due February 19 Scott Baird, Marie Delattre, Erik Ragsdale, Adrian Streit Ewan Birney, Michel Georges, Jonathan Pritchard, Molly Przeworski The PI3K-mTOR-PTEN Network in Biological Data Science Neuronal Circuits The Cell Cycle Health & Disease October 25 - 29 abstracts due August 12 August 30 - September 3 abstracts due June 10 Jeff Leek, Michael Schatz April 6 - 9 abstracts due January 22 May 17 - 21 abstracts due February 26 Anne Brunet, Lewis Cantley, Pier-Paolo Pandolfi, David Sabatini Florian Engert, Carl Petersen, Kristin Scott Angelika Amon, Jacqueline Lees, David Toczyski Neurodegenerative Diseases: Biology & The PARP Family & ADP-ribosylation Translational Control Retroviruses September 6 - 10 abstracts due June 17 Therapeutics April 13 - 16 abstracts due January 29 May 23 - 28 abstracts due March 4 November 30 - December 3 abstracts due September 16 Thomas Dever, Joel Richter, Marina Rodnina Michael Hottiger, W. Lee Kraus, Karolin Luger Kate Bishop, Louis Mansky Karen Duff, Richard Ransohoff, John Trojanowski Protein Homeostasis in Health & Disease Epigenetics & Chromatin 81st Symposium: Targeting Cancer September 13 - 17 abstracts due June 24 Blood Brain Barrier April 18 - 22 abstracts due January 29 June 1 - 5 abstracts due March 11 December 7 - 10 abstracts due September 23 Shelley Berger, Juerg Mueller, Yang Shi Judith Frydman, F. Ulrich Hartl, Harm Kampinga, Susan Lindquist, Scott Lowe, Kornelia Polyak, David Stewart, Bruce Stillman, Eileen White Robert Bell, Chenghua Gu, Stefan Liebner Richard Morimoto, Peter Walter Statistical Methods for Functional Genomics Yeast Genetics & Genomics Computational & Comparative Genomics Courses June 23 - July 6 July 26 - August 15 October 26 - November 3 Cell & Developmental Biology of Xenopus Harmen Bussemaker, Sean Davis, Olivier Elemento Grant Brown, Maitreya Dunham, Marc Gartenberg Aaron Mackey, William Pearson, Lisa Stubbs, James Taylor April 5 - 18 Mustafa Khokha, Karen Liu Advanced Techniques in Molecular Neuroscience Brain Tumors Advanced Sequencing Technologies & July 1 - 17 August 2 - 8 Applications Cary Lai, Joseph LoTurco, Anne Schaefer Candece Gladson, Anna Lasorella, Sadhan Majumder Expression, Purification & Analysis of Proteins & November 8 - 20 Protein Complexes Malachi Griffith, Obi Griffith, Elaine Mardis, Drosophila Neurobiology: Genes, Circuits & Behavior Synthetic Biology Richard McCombie, Aaron Quinlan, Michael Schatz April 5 - 18 July 1 - 21 August 2 - 15 Albert Courey, Sue-Hwa Lin, Michael Marr, Sergei Nechaev Karla Kaun, Chi-Hon Lee, Stefan Pulver Mary Dunlop, Ahmad Khalil, Vincent Noireaux, Howard Salis, Harris Wang Antibody Engineering & Phage Display Quantitative Imaging: From Cells to Molecules November 8 - 20 Frontiers & Techniques in Plant Science Programming for Biology Don Siegel, Gregg Silverman April 5 - 18 July 1 - 21 October 10 - 25 Hunter Elliott, Jennifer Waters, Torsten Wittmann Sean Cutler, Nicholas Provart, Marja Timmermans Simon Prochnik, Sofia Robb The Genome Access Course Schizophrenia & Related Disorders April 4 - 6, November 7 - 9 Metabolomics X-Ray Methods in Structural Biology Assaf Gordon, Emily Hodges, Gareth Howell, June 8 - 15 July 8 - 21 October 10 - 25 Benjamin King, Jeremy Ward Anissa Abi-Dargham, Jeremy Hall, Akira Sawa Amy Caudy, Eyal Gottlieb, Adam Rosebrock William Furey, Gary Gilliland, Alexander McPherson, Tassos Perrakis, James Pflugrath Professional Development: Single Cell Analysis Computational Neuroscience: Vision June 8 - 21 July 11 - 24 Cereal Genomics Workshop on Leadership in Bioscience Amy Herr, Michael McConnell, Gene Yeo Geoffrey Boynton, Gregory Horwitz, Jonathan Pillow October 19 - 25 March 11 - 14 Advanced Bacterial Genetics Sarah Hake, David Jackson, Carl Cohen, Dannielle Kennedy Genetics & Neurobiology of Language Doreen Ware June 8 - 28 July 25 - 31 Scientific Writing Retreat Lionello Bossi, Andrew Camilli, Houra Merrikh Simon Fisher, Kate Watkins November 16 - 20 Ion Channels & Synaptic Transmission Chromatin, Epigenetics & Gene Expression for more information: Charla Lambert, Stephen Matheson June 8 - 28 July 26 - August 15 www.cshl.edu/meetings Tiago Branco, Ian Duguid, Christoph Schmidt-Hieber Karen Adelman, Luciano Di Croce, Geeta Narlikar, Ali Shilatifard Mouse Development, Stem Cells & Cancer Imaging Structure & Function in the June 8 - 28 July 26 - August 15 Mark Lewandoski, Deneen Wellik Nervous System Michael Orger, Proteomics Lucy Palmer June 15 - 28 Michelle Cilia, Ileana Cristea, Katalin Medzihradszky, Darryl Pappin photo & poster by Drew Mendelsohn Major Program Support: Helmsley Charitable Trust, Corporate Sponsors: Agilent Technologies, Howard Hughes Medical Institute, National Institutes Bristol-Myers Squibb Company, Genentech, Inc., Social and poster session in the new Nicholls Biondi of Health, National Science Foundation Life Technologies (Thermo Fisher Scientific), Hall on a warm fall evening with the Davenport house Monsanto Company, New England BioLabs and towering Ginkgo biloba tree in the background..
Load more

Recommended publications
  • USA Education Ph.D., Biology, Massachusetts Institute of Tech
    Victor R. Ambros, Ph.D. Silverman Professor of Natural Sciences Program in Molecular Medicine University of Massachusetts Medical School373 Plantation Street, Suite 306 Worcester, MA 01605 (508) 856-6380 [email protected] Personal Born: Hanover, NH, USA on December 1, 1953 Citizenship: USA Education Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, MA 1976-1979 Thesis Title: The protein covalently linked to the 5' end of poliovirus RNA Advisor: Dr. David Baltimore B.S., Biology, Massachusetts Institute of Technology, Cambridge, MA 1971-1975 Professional Appointments Silverman Professor of Natural Sciences 2009-present Co-Director, RNA Therapeutics Institute 2009-2016 Professor, Program in Molecular Medicine 2008-present University of Massachusetts Medical School, Worcester, MA Professor of Genetics, Dartmouth Medical School 2001-2007 Professor, Biological Sciences, Dartmouth Medical School 1996-2001 Associate Professor, Biological Sciences, Dartmouth Medical School 1992-1996 Associate Professor, Department of Cellular and Development Biology, 1988-1992 Harvard University, Cambridge, MA Assistant Professor, Department of Cellular and Development Biology, 1985-1988 Harvard University, Cambridge, MA Postdoctoral Research 1979-1985 Supervisor: Dr. H. Robert Horvitz Massachusetts Institute of Technology, Cambridge, MA Graduate Research 1976-1979 Supervisor: Dr. David Baltimore Massachusetts Institute of Technology, Cambridge, MA Research Assistant 1975-1976 Supervisor: Dr. David Baltimore Center for Cancer Research,
    [Show full text]
  • The EMBL-European Bioinformatics Institute the Hub for Bioinformatics in Europe
    The EMBL-European Bioinformatics Institute The hub for bioinformatics in Europe Blaise T.F. Alako, PhD [email protected] www.ebi.ac.uk What is EMBL-EBI? • Part of the European Molecular Biology Laboratory • International, non-profit research institute • Europe’s hub for biological data, services and research The European Molecular Biology Laboratory Heidelberg Hamburg Hinxton, Cambridge Basic research Structural biology Bioinformatics Administration Grenoble Monterotondo, Rome EMBO EMBL staff: 1500 people Structural biology Mouse biology >60 nationalities EMBL member states Austria, Belgium, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom Associate member state: Australia Who we are ~500 members of staff ~400 work in services & support >53 nationalities ~120 focus on basic research EMBL-EBI’s mission • Provide freely available data and bioinformatics services to all facets of the scientific community in ways that promote scientific progress • Contribute to the advancement of biology through basic investigator-driven research in bioinformatics • Provide advanced bioinformatics training to scientists at all levels, from PhD students to independent investigators • Help disseminate cutting-edge technologies to industry • Coordinate biological data provision throughout Europe Services Data and tools for molecular life science www.ebi.ac.uk/services Browse our services 9 What services do we provide? Labs around the
    [Show full text]
  • Functional Effects Detailed Research Plan
    GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data.
    [Show full text]
  • Looking at Earth: an Astronaut's Journey Induction Ceremony 2017
    american academy of arts & sciences winter 2018 www.amacad.org Bulletin vol. lxxi, no. 2 Induction Ceremony 2017 Class Speakers: Jane Mayer, Ursula Burns, James P. Allison, Heather K. Gerken, and Gerald Chan Annual David M. Rubenstein Lecture Looking at Earth: An Astronaut’s Journey David M. Rubenstein and Kathryn D. Sullivan ALSO: How Are Humans Different from Other Great Apes?–Ajit Varki, Pascal Gagneux, and Fred H. Gage Advancing Higher Education in America–Monica Lozano, Robert J. Birgeneau, Bob Jacobsen, and Michael S. McPherson Redistricting and Representation–Patti B. Saris, Gary King, Jamal Greene, and Moon Duchin noteworthy Select Prizes and Andrea Bertozzi (University of James R. Downing (St. Jude Chil- Barbara Grosz (Harvard Univer- California, Los Angeles) was se- dren’s Research Hospital) was sity) is the recipient of the Life- Awards to Members lected as a 2017 Simons Investi- awarded the 2017 E. Donnall time Achievement Award of the gator by the Simons Foundation. Thomas Lecture and Prize by the Association for Computational American Society of Hematology. Linguistics. Nobel Prize in Chemistry, Clara D. Bloomfield (Ohio State 2017 University) is the recipient of the Carol Dweck (Stanford Univer- Christopher Hacon (University 2017 Robert A. Kyle Award for sity) was awarded the inaugural of Utah) was awarded the Break- Joachim Frank (Columbia Univer- Outstanding Clinician-Scientist, Yidan Prize. through Prize in Mathematics. sity) presented by the Mayo Clinic Di- vision of Hematology. Felton Earls (Harvard Univer- Naomi Halas (Rice University) sity) is the recipient of the 2018 was awarded the 2018 Julius Ed- Nobel Prize in Economic Emmanuel J.
    [Show full text]
  • Exploring the Structure and Function Paradigm Oliver C Redfern, Benoit Dessailly and Christine a Orengo
    Available online at www.sciencedirect.com Exploring the structure and function paradigm Oliver C Redfern, Benoit Dessailly and Christine A Orengo Advances in protein structure determination, led by the Figure 1 shows that as the international genomics initiat- structural genomics initiatives have increased the proportion of ives gather pace, both the number of sequences and novel folds deposited in the Protein Data Bank. However, these protein families are still growing at an exponential rate, structures are often not accompanied by functional annotations although the rate of expansion of protein families is with experimental confirmation. In this review, we reassess the substantially less. This trend is also observed among meaning of structural novelty and examine its relevance domain families, which are 10-fold fewer (<10 000) than to the complexity of the structure-function paradigm. the number of protein families. By targeting these, the Recent advances in the prediction of protein function from structural genomics initiatives can aim to characterise the structure are discussed, as well as new sequence-based major building blocks of whole proteins and since these methods for partitioning large, diverse superfamilies into domains recur in different combination in the genomes, it biologically meaningful clusters. Obtaining structural data for will be an important step towards understanding the these functionally coherent groups of proteins will allow us to complete structural repertoire in nature. Furthermore, better understand the relationship between structure and the complement of molecular functions found within function. an organism is likely to be even fewer. For example, 97% of proteins in yeast can be assigned one or more of Address 4000 unique GO terms.
    [Show full text]
  • Pnas11141toc 3..7
    October 14, 2014 u vol. 111 u no. 41 u 14637–14960 Cover image: Pictured is a duck during feeding. Ducks and other tactile foraging birds rely on their sense of touch, rather than sight, to feed in murky water. Eve R. Schneider et al. found that the trigeminal ganglia in duck bills contain a high number of neurons hypersensitive to mechanical stimuli. Multiplication of mechanosensitive neurons, however, may reduce the number of thermosensitive neurons. This tradeoff may confer an advantage on tactile foraging birds, which can tolerate cold water temperatures without diminishing feeding efficiency. See the article by Schneider et al. on pages 14941–14946. Image courtesy of Eve R. Schneider (Bagriantsev Lab). From the Cover 14941 Duckbill mechanosensitivity 14675 Mobility of packaged viral DNA 14740 Strong male bonds among Guinea baboons 14822 Losing independence in microbial mutualism 14864 Density-based sickle cell detection E4288 Reply to Azuaje: Predicting effective combined Contents therapies for heterogeneous tumors Boyang Zhao, Michael T. Hemann, and Douglas A. Lauffenburger THIS WEEK IN PNAS INNER WORKINGS—An over-the-shoulder look at scientists at work 14637 In This Issue 14639 Inner Workings: Coding on the big screen Robert Frederick LETTERS (ONLINE ONLY) QNAS E4284 Delphi: Somewhere between Scylla and Charybdis? Fergus Bolger and Gene Rowe 14640 QnAs with Alan Guth E4285 Are Marine Group II Euryarchaeota significant Paul Gabrielsen contributors to tetraether lipids in the ocean? Stefan Schouten, Laura Villanueva, Ellen C. Hopmans, Marcel T. J. van der Meer, and Jaap S. Sinninghe Damsté RETROSPECTIVE E4286 Reply to Schouten et al.: Marine Group II planktonic Euryarchaeota are significant contributors to tetraether lipids in the ocean 14641 Jake MacMillan: A pioneering chemist in Sara A.
    [Show full text]
  • Profile of Gary Ruvkun
    PROFILE Profile of Gary Ruvkun wash in the faint glow of a fluo- Brush with Molecular Biology rescent lamp, a pair of serpentine The story of Ruvkun’s metamorphosis Anematode worms lie on a Petri from a keen undergraduate into a leading plate, their see-through bodies light in his field of study begins at Har- magnified 100-fold by one of several vard University, where he enrolled in microscopes arrayed in a darkened bay in a Ph.D. program in 1976 upon returning National Academy of Sciences member to the United States. Like many other Gary Ruvkun’s laboratory at Massachu- scientific institutions across the world in setts General Hospital. While one of the the mid-1970s, Harvard was astir with the worms wiggles its way around the plate, promise of recombinant DNA technol- the other shows no signs of life, ogy, and Ruvkun wasted no time em- its midsection ruptured and its innards bracing its tools. “My undergraduate strewn asunder. A filter slides into place, education had not prepared me at all for and the worms are bathed in a dull recombinant DNA, but I immersed my- green haze. The wiggling worm has a bea- self into its culture at Harvard, much of con of nerve cells in its head, the ganglia which was James Watson’s creation from lit up by a genetic trick that has rescued a decade earlier,” Ruvkun says. Propelled the worm from death; its neighbor wears Gary Ruvkun. by a desire to be a part of the culture of no such beacon. The worms were deprived basic molecular biology, all while per- of a tiny RNA molecule, called a micro- forming science with the potential to im- RNA, which helps shepherd them through not 5-year-old children.
    [Show full text]
  • Kazutoshi Mori and Peter Walter Receive the 2014 Albert Lasker Basic Medical Research Award
    Kazutoshi Mori and Peter Walter receive the 2014 Albert Lasker Basic Medical Research Award Corinne L. Williams J Clin Invest. 2014;124(10):4138-4142. https://doi.org/10.1172/JCI78419. News Cells are continuously faced with life-and-death decisions based on their ability to handle stressful situations. One indicator of stress is the accumulation of unfolded proteins within the ER, which induces a transcriptional cascade aimed at increasing the folding capacity of the ER. If the burden is too great and homeostasis cannot be restored, the response shifts from damage control to the induction of apoptotic pathways. This unfolded protein response (UPR) is conserved among all eukaryotes, and dysfunction in this pathway underlies many human diseases, including diabetes and cancer. The 2014 Albert Lasker Basic Medical Research award honors Kazutoshi Mori of Kyoto University and Peter Walter of the UCSF (Figure 1) for their contributions toward unraveling the pathways involved in mediating the complex cellular response to ER stress. A simple question In the 1970s, the identification of a set of proteins that were induced in response to viral transformation set the stage for understanding heat shock-independent cellular stress responses. These particular proteins were constitutively present in cells and notably increased in response to glucose deprivation (1) or agents that block post-translational glycosylation, such as tunicamycin. Based on this apparent glucose-dependent regulation, they became known as glucose-regulated proteins (GRPs). One
    [Show full text]
  • GSA Welcomes 2012 Board Members
    7INTERs3PRING 4HE'3!2EPORTER winter s spring 2012 New Executive GSA Welcomes 2012 Board Members Director Now on Board The Genetics Society of America New Members of the GSA Board of welcomes four new members elected Directors Adam P. Fagen, by the general membership to the Ph.D., stepped in as 2012 GSA Board of Directors. The VICE PRESIDENT: GSA’s new Executive new members are: Michael Lynch Michael Lynch, Director beginning (Indiana University), who serves as Distinguished December 1, 2011. vice president in 2012 and as GSA Professor of Dr. Fagen previously president in 2013 and Marnie E. Biology, Class of was at the American Halpern (Carnegie Institution for 1954 Professor, Society of Plant Science); Mohamed Noor (Duke Department of Biologists (ASPB), University); and John Schimenti Biology, Indiana where he was the director of public (Cornell University), who will serve as University, continued on page nineteen directors. Bloomington. Dr. Lynch is a population and evolutionary biologist and a In addition to these elected officers, long-time member of GSA. Dr. Lynch 2012 Brenda J. Andrews (University of sees GSA as the home for geneticists Toronto), Editor-in-Chief of GSA’s who study a broad base of topics GSA Award journal, G3: Genes|Genomes|Genetics, and organisms, and as a forum Recipients which was first published online in where general discussion occurs, June 2011, becomes a member of the whether based on the principles Announced Board of Directors. The bylaws have of genetics, the most pressing historically included the GENETICS GSA is pleased to announce the issues within the discipline itself, or editor-in-chief on the Board and as a responses to societal concerns and/ 2012 recipients of its five awards result of a 2011 bylaw revision, the G3 for distinguished service in the or conflicts within applied genetics.
    [Show full text]
  • 2008 Harvard / Paul F
    The 2008 Harvard / Paul F. Glenn Symposium on Aging June 23, 2008 Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Welcome to the 3rd Annual Harvard/Paul F. Glenn Symposium on Aging. Each year, the Paul F. Glenn Laboratories host the Harvard Symposium on Aging with a mission to educate the wider research community about advancements in this fast-paced field and to stimulate collaborative research in this area. We have been fortunate to have many of the leaders in the aging field speak at these symposia. As a result, attendees come not only from the Harvard research community but from across the nation and from overseas for this one day event. We are glad you could join us here today. The reasons for accelerating research molecular biology of aging are clear. First and foremost, the number of aged individuals in developed countries is growing rapidly, which is going to place an unprecedented burden on the families and the economies of those nations. Because chronic illness in the elderly is a major medical cost, enormous savings would be achieved if mortality and morbidity could be compressed within a shorter duration of time at the end of life. A study by the RAND Corporation in 2006 concluded that advances in medicine arising from aging research would be 10-100 times more cost-effective than any other medical breakthrough. Advances in aging research have shown that it is possible to extend the healthy lifespan of laboratory animals through genetic and pharmacological means. Many leaders in the aging field predict that significant strides will be made in understanding how human health and lifespan are regulated, leading to novel medicines to forestall and treat diseases of aging such as diabetes, cancer, Alzheimer’s and heart disease.
    [Show full text]
  • IST Annual Report 2019
    Annual Report 2019 IST Austria administrative and The people of IST Austria technical support staff by nationality Austria 59.4% Nationalities on campus Germany 5.6% Hungary 3.1% Poland 2.5% Romania 2.5% Scientists as well as administrative and technical support staff come Italy 2.1% Russia 1.7% from all over the world to conduct and back research at IST Austria. Czech Republic 1.4% As of December 31, 2019, a total of 72 nationalities were represented India 1.4% Slovakia 1.4% on campus. Spain 1.4% UK 1.4% Other 16.1% North America Europe Asia Canada Albania Italy Afghanistan Cuba Andorra Latvia Bangladesh El Salvador Armenia Lithuania China Mexico Austria Luxembourg South Korea USA Belarus Macedonia India Belgium Malta Iran Bosnia and Netherlands Israel Herzegovina Norway Japan Bulgaria Poland Jordan Croatia Portugal Kazakhstan Cyprus Romania Lebanon Czech Republic Serbia Mongolia Denmark Slovakia Philippines Finland Slovenia Russia France Spain Singapore Georgia Sweden Syria Germany Switzerland Vietnam Greece Turkey Hungary UK Ireland Ukraine Africa Egypt Kenya IST Austria scientists by nationality Libya Austria 14.7% Nigeria Germany 10.9% South America Italy 7.4% Argentina India 5.9% Russia 4.7% Brazil Slovakia 4.1% Chile China 4.1% Colombia Hungary 3.7% Peru Spain 3.3% Uruguay USA 3.1% Czech Republic 2.9% UK 2.4% Oceania Other 32.8% Australia Content 2 HAPPY BIRTHDAY! 40 RESEARCH 4 Foreword by the president 42 Biology 5 Board member voices 44 Computer science 6 “An Austrian miracle” 46 Mathematics A year of celebration 48 Neuroscience
    [Show full text]
  • Signature Redacted Certified By: __Signature Redacted
    Genetic Regulation of Cell Extrusion in Caenorhabditis elegans By Vivek Kumar Dwivedi M. Tech. Biochemical Engineering and Biotechnology Indian Institute of Technology Delhi, 2012 Submitted to the Department of Biology in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy at the Massachusetts Institute of Technology June 2019 2019 Massachusetts Institute of Technology. All rights reserved. The author hereby grants to MIT permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. Signature redacted Signature of Author: Department of Biology, May 28, 2019 Certified by: __Signature redacted H. Roiert Horvitz Professor of Biology Thesis Supervisor Accepted by: Signature redacted MASSACHUSETS INSTITUTE Amy . eag OF TECHNOLOGY- Professor of Biology Graduate Committee MAY 312 Co-Chair, Biology LIBRARIES ARCHIVES 1 Genetic Regulation of Cell Extrusion in Caenorhabditis elegans by Vivek Kumar Dwivedi Submitted to the MIT Department of Biology on May 28, 2019 in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Biology Abstract Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by cell- autonomous activation of the caspase-mediated apoptosis pathway, which produces a corpse that is engulfed and degraded by phagocytic cells. Cell elimination can also occur by a different method, called cell extrusion, in which the cell to be eliminated is squeezed out from a layer of cells, such as an epithelium.
    [Show full text]