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Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org PRESIDENT OF Cellular and Geology Peter K. Vogt THE ACADEMY Developmental Biology W. G. Ernst Thomas E. Wellems Ralph J. Cicerone Eric H. Davidson James P. Kennett John B. Gurdon Physics EDITOR-IN-CHIEF Eric N. Olson Human Environmental Anthony Leggett Randy Schekman Michael Rosbash Sciences Paul C. Martin David D. Sabatini Susan Hanson Jose´ N. Onuchic ASSOCIATE EDITORS Gertrud M. Schu¨pbach Immunology Physiology and William C. Clark Robert Tjian Alan Fersht Peter Cresswell Pharmacology Douglas T. Fearon Susan G. Amara Jack Halpern Cellular and Molecular Jeremy A. Sabloff Tak Wah Mak David Julius Neuroscience William E. Paul Ramon Latorre Solomon H. Snyder Pietro V. De Camilli Susan R. Wessler Ralph M. Steinman Richard L. Huganir Plant Biology L. L. Iversen Mathematics Anthony R. Cashmore Jeremy Nathans Richard V. Kadison Maarten J. Chrispeels EDITORIAL BOARD Charles F. Stevens Robion C. 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