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Table of Contents (PDF) December 13, 2016 u vol. 113 u no. 50 From the Cover 14243 Aerosol effects in turbulent clouds E8069 Caveolar coat architecture E8159 Noninvasive fetal genome analysis 14306 Chaperone for tRNA folding 14450 Social constraints on hunters’ choices Contents THIS WEEK IN PNAS Cover image: Pictured are droplets in 14163 In This Issue a turbulent cloud, illuminated by a thin sheet of laser light. The long time exposure allows the velocity field to be LETTERS (ONLINE ONLY) visualized through the streaks left by E8009 Engineered microparticles delivering oxygen to enhance radiotherapy efficacy moving cloud droplets. Kamal Kant Paul N. Span, Johan Bussink, and Johannes H. A. M. Kaanders Chandrakar et al. created turbulent clouds in the laboratory, and found that E8010 Reply to Span et al.: Rational design of oxygen microparticles for both the mean diameter and the width radiation therapy of the size distribution of cloud droplets John N. Kheir and Brian D. Polizzotti increase with decreasing aerosol concentration. The findings provide insight into the effect of turbulence and SCIENCE AND CULTURE—How science intersects with culture aerosol concentration on precipitation 14165 Looking at a shared sky, through the lens of art and cloud radiative properties. See the Adam Mann article by Chandrakar et al. on pages 14243–14248. Image courtesy of Kamal Kant Chandrakar. CORE CONCEPTS—A brief introduction to emerging topics in science 14168 Prebiotics gain prominence but remain poorly defined Alla Katsnelson COMMENTARIES 14170 Unraveling the architecture of caveolae Robert G. Parton and Brett M. Collins See companion article on page E8069 14173 Noninvasive prenatal testing to analyze the fetal genome Mary E. Norton See companion article on page E8159 14176 Two for the price of one: RNA modification enzymes as chaperones Sandra L. Wolin See companion article on page 14306 PNAS PLUS 14179 Significance Statements Brief statements written by the authors about the significance of their papers. Free online through the PNAS open access option. PNAS u December 13, 2016 u vol. 113 u no. 50 u iii–vii Downloaded by guest on September 28, 2021 14243 Aerosol indirect effect from turbulence-induced PHYSICAL SCIENCES broadening of cloud-droplet size distributions APPLIED MATHEMATICS Kamal Kant Chandrakar, Will Cantrell, Kelken Chang, David Ciochetto, Dennis Niedermeier, Mikhail Ovchinnikov, Raymond A. 14183 Data-driven parameterization of the generalized Shaw, and Fan Yang Langevin equation Huan Lei, Nathan A. Baker, and Xiantao Li 14249 Deglacial temperature history of West Antarctica Kurt M. Cuffey, Gary D. Clow, Eric J. Steig, Christo Buizert, T. J. Fudge, Michelle Koutnik, Edwin D. Waddington, Richard B. APPLIED PHYSICAL SCIENCES Alley, and Jeffrey P. Severinghaus 14189 Supramolecular PEGylation of biopharmaceuticals Matthew J. Webber, Eric A. Appel, Brittany Vinciguerra, Abel B. ENGINEERING Cortinas, Lavanya S. Thapa, Siddharth Jhunjhunwala, Lyle E8169 Stretchable multichannel antennas in soft wireless Isaacs, Robert Langer, and Daniel G. Anderson optoelectronic implants for optogenetics 14195 Geometry induced sequence of nanoscale Sung Il Park, Gunchul Shin, Jordan G. McCall, Ream Al-Hasani, Frank–Kasper and quasicrystal mesophases Aaron Norris, Li Xia, Daniel S. Brenner, Kyung Nim Noh, Sang in giant surfactants Yun Bang, Dionnet L. Bhatti, Kyung-In Jang, Seung-Kyun Kang, Kan Yue, Mingjun Huang, Ryan L. Marson, Jinlin He, Jiahao Aaron D. Mickle, Gregory Dussor, Theodore J. Price, Robert W. Huang, Zhe Zhou, Jing Wang, Chang Liu, Xuesheng Yan, Kan Gereau IV, Michael R. Bruchas, and John A. Rogers Wu, Zaihong Guo, Hao Liu, Wei Zhang, Peihong Ni, Chrys 14255 Scalable manufacturing of biomimetic moldable Wesdemiotis, Wen-Bin Zhang, Sharon C. Glotzer, hydrogels for industrial applications and Stephen Z. D. Cheng Anthony C. Yu, Haoxuan Chen, Doreen Chan, Gillie Agmon, 14201 Programmable and reversible plasmon Lyndsay M. Stapleton, Alex M. Sevit, Mark W. Tibbitt, Jesse D. mode engineering Acosta, Tony Zhang, Paul W. Franzia, Robert Langer, Ankun Yang, Alexander J. Hryn, Marc R. Bourgeois, Won-Kyu and Eric A. Appel Lee, Jingtian Hu, George C. Schatz, and Teri W. Odom 14261 Optically transparent semiconducting polymer 14207 Accurate and scalable social recommendation using nanonetwork for flexible and transparent electronics mixed-membership stochastic block models Kilho Yu, Byoungwook Park, Geunjin Kim, Chang-Hyun Kim, Antonia Godoy-Lorite, Roger Guimera`, Cristopher Moore, Sungjun Park, Jehan Kim, Suhyun Jung, Soyeong Jeong, and Marta Sales-Pardo Sooncheol Kwon, Hongkyu Kang, Junghwan Kim, Myung-Han Yoon, and Kwanghee Lee 14213 Enhanced stochastic fluctuations to measure steep adhesive energy landscapes 14267 Continuous flow synthesis of ZSM-5 zeolite on the Ahmad Haider, Daniel Potter, and Todd A. Sulchek order of seconds Zhendong Liu, Kotatsu Okabe, Chokkalingam Anand, Yasuo Yonezawa, Jie Zhu, Hiroki Yamada, Akira Endo, Yutaka Yanaba, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Takeshi Yoshikawa, Koji Ohara, Tatsuya Okubo, and Toru Wakihara E8021 Near-atomic structural model for bacterial DNA replication initiation complex and its PHYSICS functional insights 14272 High thermoelectricpower factor in Masahiro Shimizu, Yasunori Noguchi, Yukari Sakiyama, Hironori graphene/hBN devices Kawakami, Tsutomu Katayama, and Shoji Takada Junxi Duan, Xiaoming Wang, Xinyuan Lai, Guohong Li, Kenji Watanabe (渡邊賢司), Takashi Taniguchi, Mona Zebarjadi, CHEMISTRY and Eva Y. Andrei E8011 Carrier dynamics and the role of surface defects: Designing a photocatalyst for gas-phase STATISTICS CO2 reduction 14277 Framework for making better predictions by directly Laura B. Hoch, Paul Szymanski, Kulbir Kaur Ghuman, Le He, estimating variables’ predictivity Kristine Liao, Qiao Qiao, Laura M. Reyes, Yimei Zhu, Mostafa A. Adeline Lo, Herman Chernoff, Tian Zheng, and Shaw-Hwa Lo El-Sayed, Chandra Veer Singh, and Geoffrey A. Ozin 14283 Rapid emergence and mechanisms of resistance by 14219 In vivo bioluminescence imaging reveals copper U87 glioblastoma cells to doxorubicin in an in vitro deficiency in a murine model of nonalcoholic tumor microfluidic ecology fatty liver disease Jeonghun Han, Yukyung Jun, So Hyun Kim, Hong-Hoa Hoang, Marie C. Heffern, Hyo Min Park, Ho Yu Au-Yeung, Genevieve C. Yeonjoo Jung, Suyeon Kim, Jaesang Kim, Robert H. Austin, Van de Bittner, Cheri M. Ackerman, Andreas Stahl, Sanghyuk Lee, and Sungsu Park and Christopher J. Chang 14330 Evaluating the evaluation of cancer driver genes 14225 Enhanced limonene production in cyanobacteria Collin J. Tokheim, Nickolas Papadopoulos, Kenneth W. Kinzler, reveals photosynthesis limitations Bert Vogelstein, and Rachel Karchin Xin Wang, Wei Liu, Changpeng Xin, Yi Zheng, Yanbing Cheng, Su Sun, Runze Li, Xin-Guang Zhu, Susie Y. Dai, Peter M. SOCIAL SCIENCES Rentzepis, and Joshua S. Yuan 14231 Design principles for nonequilibrium self-assembly PSYCHOLOGICAL AND COGNITIVE SCIENCES Michael Nguyen and Suriyanarayanan Vaikuntanathan 14289 Map reading, navigating from maps, and the medial temporal lobe EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Zhisen J. Urgolites, Soyun Kim, Ramona O. Hopkins, 14237 Siderophore-based microbial adaptations to iron and Larry R. Squire scarcity across the eastern Pacific Ocean 14438 Psychopathic individuals exhibit but do not avoid Rene M. Boiteau, Daniel R. Mende, Nicholas J. Hawco, regret during counterfactual decision making Matthew R. McIlvin, Jessica N. Fitzsimmons, Mak A. Saito, Arielle Baskin-Sommers, Allison M. Stuppy-Sullivan, Peter N. Sedwick, Edward F. DeLong, and Daniel J. Repeta and Joshua W. Buckholtz iv u www.pnas.org Contents Downloaded by guest on September 28, 2021 SUSTAINABILITY SCIENCE 14277 Framework for making better predictions by directly E8089 Evaluating early-warning indicators of critical estimating variables’ predictivity transitions in natural aquatic ecosystems Adeline Lo, Herman Chernoff, Tian Zheng, and Shaw-Hwa Lo Alena Sonia Gsell, Ulrike Scharfenberger, Deniz O¨ zkundakci, 14330 Evaluating the evaluation of cancer driver genes Annika Walters, Lars-Anders Hansson, Annette B. G. Janssen, Collin J. Tokheim, Nickolas Papadopoulos, Kenneth W. Kinzler, Peeter No˜ges, Philip C. Reid, Daniel E. Schindler, Ellen Van Bert Vogelstein, and Rachel Karchin Donk, Vasilis Dakos, and Rita Adrian 14336 A functional role for intrinsic disorder in the 14294 Meeting the Sustainable Development Goals leads to tau-tubulin complex lower world population growth Ana M. Melo, Juliana Coraor, Garrett Alpha-Cobb, Shana Guy J. Abel, Bilal Barakat, Samir KC, and Wolfgang Lutz Elbaum-Garfinkle, Abhinav Nath, and Elizabeth Rhoades 14450 How constraints affect the hunter’sdecisiontoshoot adeer CELL BIOLOGY Florian K. Diekert, Andries Richter, Inger Maren Rivrud, E8059 MyTH4-FERM myosins have an ancient and conserved and Atle Mysterud role in filopod formation Karl J. Petersen, Holly V. Goodson, Ashley L. Arthur, G. W. Gant BIOLOGICAL SCIENCES Luxton, Anne Houdusse, and Margaret A. Titus BIOCHEMISTRY E8069 Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs E8021 Near-atomic structural model for bacterial DNA Miriam Stoeber, Pascale Schellenberger, C. Alistair Siebert, replication initiation complex and its Cedric Leyrat, Ari Helenius, and Kay Gru¨newald functional insights See Commentary on page 14170 Masahiro Shimizu, Yasunori Noguchi, Yukari Sakiyama, Hironori Kawakami, Tsutomu Katayama, and Shoji Takada 14342 Multistep regulation of autophagy by WNK1
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