December 13, 2016 u vol. 113 u no. 50

From the Cover

14243 Aerosol effects in turbulent clouds E8069 Caveolar coat architecture E8159 Noninvasive fetal genome analysis 14306 Chaperone for tRNA folding 14450 Social constraints on hunters’ choices

Contents

THIS WEEK IN PNAS Cover image: Pictured are droplets in 14163 In This Issue a turbulent cloud, illuminated by a thin sheet of laser light. The long time exposure allows the velocity field to be LETTERS (ONLINE ONLY) visualized through the streaks left by E8009 Engineered microparticles delivering oxygen to enhance radiotherapy efficacy moving cloud droplets. Kamal Kant Paul N. Span, Johan Bussink, and Johannes H. A. M. Kaanders Chandrakar et al. created turbulent clouds in the laboratory, and found that E8010 Reply to Span et al.: Rational design of oxygen microparticles for both the mean diameter and the width radiation therapy of the size distribution of cloud droplets John N. Kheir and Brian D. Polizzotti increase with decreasing aerosol concentration. The findings provide insight into the effect of turbulence and SCIENCE AND CULTURE—How science intersects with culture aerosol concentration on precipitation 14165 Looking at a shared sky, through the lens of art and cloud radiative properties. See the Adam Mann article by Chandrakar et al. on pages 14243–14248. Image courtesy of Kamal Kant Chandrakar. CORE CONCEPTS—A brief introduction to emerging topics in science 14168 Prebiotics gain prominence but remain poorly defined Alla Katsnelson

COMMENTARIES 14170 Unraveling the architecture of caveolae Robert G. Parton and Brett M. Collins See companion article on page E8069 14173 Noninvasive prenatal testing to analyze the fetal genome Mary E. Norton See companion article on page E8159 14176 Two for the price of one: RNA modification enzymes as chaperones Sandra L. Wolin See companion article on page 14306

PNAS PLUS 14179 Significance Statements Brief statements written by the authors about the significance of their papers.

Free online through the PNAS open access option. PNAS u December 13, 2016 u vol. 113 u no. 50 u iii–vii Downloaded by guest on September 28, 2021 14243 Aerosol indirect effect from turbulence-induced PHYSICAL SCIENCES broadening of cloud-droplet size distributions APPLIED MATHEMATICS Kamal Kant Chandrakar, Will Cantrell, Kelken Chang, David Ciochetto, Dennis Niedermeier, Mikhail Ovchinnikov, Raymond A. 14183 Data-driven parameterization of the generalized Shaw, and Fan Yang Langevin equation Huan Lei, Nathan A. Baker, and Xiantao Li 14249 Deglacial temperature history of West Antarctica Kurt M. Cuffey, Gary D. Clow, Eric J. Steig, Christo Buizert, T. J. Fudge, Michelle Koutnik, Edwin D. Waddington, Richard B. APPLIED PHYSICAL SCIENCES Alley, and Jeffrey P. Severinghaus 14189 Supramolecular PEGylation of biopharmaceuticals Matthew J. Webber, Eric A. Appel, Brittany Vinciguerra, Abel B. ENGINEERING Cortinas, Lavanya S. Thapa, Siddharth Jhunjhunwala, Lyle E8169 Stretchable multichannel antennas in soft wireless Isaacs, Robert Langer, and Daniel G. Anderson optoelectronic implants for optogenetics 14195 Geometry induced sequence of nanoscale Sung Il Park, Gunchul Shin, Jordan G. McCall, Ream Al-Hasani, Frank–Kasper and quasicrystal mesophases Aaron Norris, Li Xia, Daniel S. Brenner, Kyung Nim Noh, Sang in giant surfactants Yun Bang, Dionnet L. Bhatti, Kyung-In Jang, Seung-Kyun Kang, Kan Yue, Mingjun Huang, Ryan L. Marson, Jinlin He, Jiahao Aaron D. Mickle, Gregory Dussor, Theodore J. Price, Robert W. Huang, Zhe Zhou, Jing Wang, Chang Liu, Xuesheng Yan, Kan Gereau IV, Michael R. Bruchas, and John A. Rogers Wu, Zaihong Guo, Hao Liu, Wei Zhang, Peihong Ni, Chrys 14255 Scalable manufacturing of biomimetic moldable Wesdemiotis, Wen-Bin Zhang, Sharon C. Glotzer, hydrogels for industrial applications and Stephen Z. D. Cheng Anthony C. Yu, Haoxuan Chen, Doreen Chan, Gillie Agmon, 14201 Programmable and reversible plasmon Lyndsay M. Stapleton, Alex M. Sevit, Mark W. Tibbitt, Jesse D. mode engineering Acosta, Tony Zhang, Paul W. Franzia, Robert Langer, Ankun Yang, Alexander J. Hryn, Marc R. Bourgeois, Won-Kyu and Eric A. Appel Lee, Jingtian Hu, George C. Schatz, and Teri W. Odom 14261 Optically transparent semiconducting polymer 14207 Accurate and scalable social recommendation using nanonetwork for flexible and transparent electronics mixed-membership stochastic block models Kilho Yu, Byoungwook Park, Geunjin Kim, Chang-Hyun Kim, Antonia Godoy-Lorite, Roger Guimera`, Cristopher Moore, Sungjun Park, Jehan Kim, Suhyun Jung, Soyeong Jeong, and Marta Sales-Pardo Sooncheol Kwon, Hongkyu Kang, Junghwan Kim, Myung-Han Yoon, and Kwanghee Lee 14213 Enhanced stochastic fluctuations to measure steep adhesive energy landscapes 14267 Continuous flow synthesis of ZSM-5 zeolite on the Ahmad Haider, Daniel Potter, and Todd A. Sulchek order of seconds Zhendong Liu, Kotatsu Okabe, Chokkalingam Anand, Yasuo Yonezawa, Jie Zhu, Hiroki Yamada, Akira Endo, Yutaka Yanaba, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Takeshi Yoshikawa, Koji Ohara, Tatsuya Okubo, and Toru Wakihara E8021 Near-atomic structural model for bacterial DNA replication initiation complex and its PHYSICS functional insights 14272 High thermoelectricpower factor in Masahiro Shimizu, Yasunori Noguchi, Yukari Sakiyama, Hironori graphene/hBN devices Kawakami, Tsutomu Katayama, and Shoji Takada Junxi Duan, Xiaoming Wang, Xinyuan Lai, Guohong Li, Kenji Watanabe (渡邊賢司), Takashi Taniguchi, Mona Zebarjadi, CHEMISTRY and Eva Y. Andrei E8011 Carrier dynamics and the role of surface defects: Designing a photocatalyst for gas-phase STATISTICS CO2 reduction 14277 Framework for making better predictions by directly Laura B. Hoch, Paul Szymanski, Kulbir Kaur Ghuman, Le He, estimating variables’ predictivity Kristine Liao, Qiao Qiao, Laura M. Reyes, Yimei Zhu, Mostafa A. Adeline Lo, Herman Chernoff, Tian Zheng, and Shaw-Hwa Lo El-Sayed, Chandra Veer Singh, and Geoffrey A. Ozin 14283 Rapid emergence and mechanisms of resistance by 14219 In vivo bioluminescence imaging reveals copper U87 glioblastoma cells to doxorubicin in an in vitro deficiency in a murine model of nonalcoholic tumor microfluidic ecology fatty liver disease Jeonghun Han, Yukyung Jun, So Hyun Kim, Hong-Hoa Hoang, Marie C. Heffern, Hyo Min Park, Ho Yu Au-Yeung, Genevieve C. Yeonjoo Jung, Suyeon Kim, Jaesang Kim, Robert H. Austin, Van de Bittner, Cheri M. Ackerman, Andreas Stahl, Sanghyuk Lee, and Sungsu Park and Christopher J. Chang 14330 Evaluating the evaluation of cancer driver genes 14225 Enhanced limonene production in cyanobacteria Collin J. Tokheim, Nickolas Papadopoulos, Kenneth W. Kinzler, reveals photosynthesis limitations Bert Vogelstein, and Rachel Karchin Xin Wang, Wei Liu, Changpeng Xin, Yi Zheng, Yanbing Cheng, Su Sun, Runze Li, Xin-Guang Zhu, Susie Y. Dai, Peter M. SOCIAL SCIENCES Rentzepis, and Joshua S. Yuan 14231 Design principles for nonequilibrium self-assembly PSYCHOLOGICAL AND COGNITIVE SCIENCES Michael Nguyen and Suriyanarayanan Vaikuntanathan 14289 Map reading, navigating from maps, and the medial temporal lobe EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Zhisen J. Urgolites, Soyun Kim, Ramona O. Hopkins, 14237 Siderophore-based microbial adaptations to iron and Larry R. Squire scarcity across the eastern Pacific Ocean 14438 Psychopathic individuals exhibit but do not avoid Rene M. Boiteau, Daniel R. Mende, Nicholas J. Hawco, regret during counterfactual decision making Matthew R. McIlvin, Jessica N. Fitzsimmons, Mak A. Saito, Arielle Baskin-Sommers, Allison M. Stuppy-Sullivan, Peter N. Sedwick, Edward F. DeLong, and Daniel J. Repeta and Joshua W. Buckholtz

iv u www.pnas.org Contents Downloaded by guest on September 28, 2021 SUSTAINABILITY SCIENCE 14277 Framework for making better predictions by directly E8089 Evaluating early-warning indicators of critical estimating variables’ predictivity transitions in natural aquatic ecosystems Adeline Lo, Herman Chernoff, Tian Zheng, and Shaw-Hwa Lo Alena Sonia Gsell, Ulrike Scharfenberger, Deniz O¨ zkundakci, 14330 Evaluating the evaluation of cancer driver genes Annika Walters, Lars-Anders Hansson, Annette B. G. Janssen, Collin J. Tokheim, Nickolas Papadopoulos, Kenneth W. Kinzler, Peeter No˜ges, Philip C. Reid, Daniel E. Schindler, Ellen Van Bert Vogelstein, and Rachel Karchin Donk, Vasilis Dakos, and Rita Adrian 14336 A functional role for intrinsic disorder in the 14294 Meeting the Sustainable Development Goals leads to tau-tubulin complex lower world population growth Ana M. Melo, Juliana Coraor, Garrett Alpha-Cobb, Shana Guy J. Abel, Bilal Barakat, Samir KC, and Wolfgang Lutz Elbaum-Garfinkle, Abhinav Nath, and Elizabeth Rhoades 14450 How constraints affect the hunter’sdecisiontoshoot adeer CELL BIOLOGY Florian K. Diekert, Andries Richter, Inger Maren Rivrud, E8059 MyTH4-FERM myosins have an ancient and conserved and Atle Mysterud role in filopod formation Karl J. Petersen, Holly V. Goodson, Ashley L. Arthur, G. W. Gant BIOLOGICAL SCIENCES Luxton, Anne Houdusse, and Margaret A. Titus

BIOCHEMISTRY E8069 Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs E8021 Near-atomic structural model for bacterial DNA Miriam Stoeber, Pascale Schellenberger, C. Alistair Siebert, replication initiation complex and its Cedric Leyrat, Ari Helenius, and Kay Gru¨newald functional insights See Commentary on page 14170 Masahiro Shimizu, Yasunori Noguchi, Yukari Sakiyama, Hironori Kawakami, Tsutomu Katayama, and Shoji Takada 14342 Multistep regulation of autophagy by WNK1 14219 In vivo bioluminescence imaging reveals copper Sachith Gallolu Kankanamalage, A-Young Lee, Chonlarat deficiency in a murine model of nonalcoholic Wichaidit, Andres Lorente-Rodriguez, Akansha M. Shah, Steve Stippec, Angelique W. Whitehurst, and Melanie H. Cobb fatty liver disease Marie C. Heffern, Hyo Min Park, Ho Yu Au-Yeung, Genevieve C. 14348 Spatiotemporal imaging of small GTPases activity in Van de Bittner, Cheri M. Ackerman, Andreas Stahl, live cells and Christopher J. Chang Stephanie Voss, Dennis M. Kru¨ger, Oliver Koch, and Yao-Wen Wu 14300 Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS DEVELOPMENTAL BIOLOGY Litao Sun, Youngzee Song, David Blocquel, Xiang-Lei Yang, E8079 Planar cell polarity signaling in the uterus directs and Paul Schimmel appropriate positioning of the crypt for 14306 RNA modification enzyme TruB is a tRNA chaperone embryo implantation Laura Carole Keffer-Wilkes, Govardhan Reddy Veerareddygari, Jia Yuan, Jeeyeon Cha, Wenbo Deng, Amanda Bartos, Xiaofei and Ute Kothe Sun, Hsin-Yi Henry Ho, Jean-Paul Borg, Terry P. Yamaguchi, Yingzi Yang, and Sudhansu K. Dey See Commentary on page 14176 14312 The structure of the catechin-binding site of human 14354 Retinoic acid signaling determines the fate of uterine sulfotransferase 1A1 stroma in the mouse Müllerian duct Tadaaki Nakajima, Taisen Iguchi, and Tomomi Sato Ian Cook, Ting Wang, Mark Girvin, and Thomas S. Leyh 14318 An α/β-hydrolase fold protein in the biosynthesis of 14360 EGFR signaling is critical for maintaining the superficial thiostrepton exhibits a dual activity for endopeptidyl layer of articular cartilage and preventing hydrolysis and epoxide ring opening/macrocyclization osteoarthritis initiation Qingfei Zheng, Shoufeng Wang, Panpan Duan, Rijing Liao, Haoruo Jia, Xiaoyuan Ma, Wei Tong, Basak Doyran, Zeyang Sun, Dandan Chen, and Wen Liu Luqiang Wang, Xianrong Zhang, Yilu Zhou, Farid Badar, Abhishek Chandra, X. Lucas Lu, Yang Xia, Lin Han, Motomi 14324 Structure and mechanism of NOV1, a Enomoto-Iwamoto, and Ling Qin resveratrol-cleaving dioxygenase Ryan P. McAndrew, Noppadon Sathitsuksanoh, Michael M. ECOLOGY Mbughuni, Richard A. Heins, Jose H. Pereira, Anthe George, KennethL.Sale,BrianG.Fox,BlakeA.Simmons,andPaulD.Adams E8089 Evaluating early-warning indicators of critical transitions in natural aquatic ecosystems ¨ BIOPHYSICS AND COMPUTATIONAL BIOLOGY Alena Sonia Gsell, Ulrike Scharfenberger, Deniz Ozkundakci, Annika Walters, Lars-Anders Hansson, Annette B. G. Janssen, E8031 Stability, folding dynamics, and long-range Peeter No˜ges, Philip C. Reid, Daniel E. Schindler, Ellen Van conformational transition of the synaptic Donk, Vasilis Dakos, and Rita Adrian t-SNARE complex 14283 Rapid emergence and mechanisms of resistance by Xinming Zhang, Aleksander A. Rebane, Lu Ma, Feng Li (李峰), U87 glioblastoma cells to doxorubicin in an in vitro Junyi Jiao, Hong Qu, Frederic Pincet, James E. Rothman, and Yongli Zhang tumor microfluidic ecology Jeonghun Han, Yukyung Jun, So Hyun Kim, Hong-Hoa Hoang, E8041 Mechanism of the intrinsic arginine finger in Yeonjoo Jung, Suyeon Kim, Jaesang Kim, Robert H. Austin, heterotrimeric G proteins Sanghyuk Lee, and Sungsu Park Daniel Mann, Christian Teuber, Stefan A. Tennigkeit, Grit Schro¨ter, Klaus Gerwert, and Carsten Ko¨tting ENVIRONMENTAL SCIENCES E8051 Elucidating the druggable interface of protein−protein 14237 Siderophore-based microbial adaptations to iron interactions using fragment docking and scarcity across the eastern Pacific Ocean coevolutionary analysis Rene M. Boiteau, Daniel R. Mende, Nicholas J. Hawco, Fang Bai, Faruck Morcos, Ryan R. Cheng, Hualiang Jiang, Matthew R. McIlvin, Jessica N. Fitzsimmons, Mak A. Saito, and Jose´ N. Onuchic Peter N. Sedwick, Edward F. DeLong, and Daniel J. Repeta

Contents PNAS u December 13, 2016 u vol. 113 u no. 50 u v Downloaded by guest on September 28, 2021 GENETICS E8131 Egr2 and Egr3 in regulatory T cells cooperatively E8096 Selective sweep suggests transcriptional regulation control systemic autoimmunity through may underlie Plasmodium vivax resilience to Ltbp3-mediated TGF-β3 production malaria control measures in Cambodia Kaoru Morita, Tomohisa Okamura, Mariko Inoue, Toshihiko Christian M. Parobek, Jessica T. Lin, David L. Saunders, Eric J. Komai, Shuzo Teruya, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Barnett, Chanthap Lon, Charlotte A. Lanteri, Sujata Shoda, Kazuhiko Yamamoto, and Keishi Fujio Balasubramanian, Nicholas Brazeau, Derrick K. DeConti, E8141 Identifying species of symbiont bacteria from the human Deen L. Garba, Steven R. Meshnick, Michele D. Spring, Char gut that, alone, can induce intestinal Th17 cells in mice Meng Chuor, Jeffrey A. Bailey, and Jonathan J. Juliano Tze Guan Tan, Esen Sefik, Naama Geva-Zatorsky, Lindsay Kua, E8106 DNA methylome of the 20-gigabase Norway Debdut Naskar, Fei Teng, Lesley Pasman, Adriana Ortiz-Lopez, spruce genome Ray Jupp, Hsin-Jung Joyce Wu, Dennis L. Kasper, Christophe Israel Ausin, Suhua Feng, Chaowei Yu, Wanlu Liu, Hsuan Yu Kuo, Benoist, and Diane Mathis + Elise L. Jacobsen, Jixian Zhai, Javier Gallego-Bartolome, Lin 14378 Heterogeneous yet stable Vδ2( ) T-cell profiles define Wang, Ulrika Egertsdotter, Nathaniel R. Street, Steven E. distinct cytotoxic effector potentials in healthy Jacobsen, and Haifeng Wang human individuals E8114 Global analysis of genomic instability caused by DNA Paul L. Ryan, Nital Sumaria, Christopher J. Holland, Claire M. replication stress in Saccharomyces cerevisiae Bradford, Natalia Izotova, Capucine L. Grandjean, Ali S. Jawad, Dao-Qiong Zheng, Ke Zhang, Xue-Chang Wu, Piotr A. Lesley A. Bergmeier, and Daniel J. Pennington Mieczkowski, and Thomas D. Petes 14384 Familial Mediterranean fever mutations lift the 14366 A high-throughput small molecule screen identifies obligatory requirement for microtubules in synergism between DNA methylation and Aurora Pyrin inflammasome activation kinase pathways for X reactivation Hanne Van Gorp, Pedro H. V. Saavedra, Nathalia M. de Derek Lessing, Thomas O. Dial, Chunyao Wei, Bernhard Payer, Vasconcelos, Nina Van Opdenbosch, Lieselotte Vande Walle, Lieselot L. G. Carrette, Barry Kesner, Attila Szanto, Ajit Jadhav, Magdalena Matusiak, Giusi Prencipe, Antonella Insalaco, Filip David J. Maloney, Anton Simeonov, Jimmy Theriault, Thomas Van Hauwermeiren, Dieter Demon, Delfien J. Bogaert, Melissa Hasaka, Antonio Bedalov, Marisa S. Bartolomei, and Jeannie T. Lee Dullaers, Elfride De Baere, Tino Hochepied, Joke Dehoorne, KLB Karim Y. Vermaelen, Filomeen Haerynck, Fabrizio De Benedetti, 14372 is associated with alcohol drinking, and its gene and Mohamed Lamkanfi product β-Klotho is necessary for FGF21 regulation of alcohol preference 14390 MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1–IRF3 signaling axis Gunter Schumann, Chunyu Liu, Paul O’Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Minji Seo, Seong-Ok Lee, Ji-Hoon Kim, Yujin Hong, Seongchan Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Kim, Yeumin Kim, Dal-Hee Min, Young-Yun Kong, Jinwook Shin, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, and Kwangseog Ahn Stefan Enroth, Krista Fischer, Jenni Ha¨llfors, Sarah E. Harris, Saskia Hieber, Edith Hofer, Jouke-Jan Hottenga, A˚sa MEDICAL SCIENCES Johansson, Peter K. Joshi, Niina Kaartinen, Jaana Laitinen, E8151 TNFα-stimulated gene-6 (TSG6) activates macrophage Rozenn Lemaitre, Anu Loukola, Jian’an Luan, Leo-Pekka phenotype transition to prevent inflammatory Lyytika¨inen, Massimo Mangino, Ani Manichaikul, Hamdi lung injury Mbarek, Yuri Milaneschi, Alireza Moayyeri, Kenneth Mukamal, Christopher Nelson, Jennifer Nettleton, Eemil Partinen, Rajesh Manish Mittal, Chinnaswamy Tiruppathi, Saroj Nepal, You-Yang Rawal, Antonietta Robino, Lynda Rose, Cinzia Sala, Takashi Zhao, Dagmara Grzych, Dheeraj Soni, Darwin J. Prockop, Satoh, Reinhold Schmidt, Katharina Schraut, Robert Scott, and Asrar B. Malik Albert Vernon Smith, John M. Starr, Alexander Teumer, Stella E8159 Second generation noninvasive fetal genome analysis Trompet, Andre´ G. Uitterlinden, Cristina Venturini, Anne-Claire reveals de novo mutations, single-base parental Vergnaud, Niek Verweij, Veronique Vitart, Dragana Vuckovic, inheritance, and preferred DNA ends Juho Wedenoja, Loic Yengo, Bing Yu, Weihua Zhang, Jing Hua K. C. Allen Chan, Peiyong Jiang, Kun Sun, Yvonne K. Y. Cheng, Zhao, Dorret I. Boomsma, John Chambers, Daniel I. Chasman, Yu K. Tong, Suk Hang Cheng, Ada I. C. Wong, Irena Hudecova, Toniolo Daniela, Eco de Geus, Ian Deary, Johan G. Eriksson, Tak Y. Leung, Rossa W. K. Chiu, and Yuk Ming To˜nu Esko, Volker Eulenburg, Oscar H. Franco, Philippe Froguel, Christian Gieger, Hans J. Grabe, Vilmundur Gudnason, See Commentary on page 14173 Ulf Gyllensten, Tamara B. Harris, Anna-Liisa Hartikainen, Andrew C. 14396 Antagonists of growth hormone-releasing hormone Heath, Lynne Hocking, Albert Hofman, Cornelia Huth, Marjo-Riitta receptor induce apoptosis specifically in Jarvelin,J.WouterJukema,JaakkoKaprio,JaspalS.Kooner, retinoblastoma cells Zoltan Kutalik, Jari Lahti, Claudia Langenberg, Terho Lehtima¨ki, Wai Kit Chu, Ka Sin Law, Sun On Chan, Jason Cheuk Sing Yam, Li Yongmei Liu, Pamela A. F. Madden, Nicholas Martin, Alanna Jia Chen, Hao Zhang, Herman S. Cheung, Norman L. Block, Morrison, Brenda Penninx, Nicola Pirastu, Bruce Psaty, Olli Andrew V. Schally, and Chi Pui Pang Raitakari, Paul Ridker, Richard Rose, Jerome I. Rotter, Nilesh J. Samani, Helena Schmidt, Tim D. Spector, David Stott, David 14402 Activation of mutant TERT promoter by RAS-ERK Strachan, Ioanna Tzoulaki, Pim van der Harst, Cornelia M. van signaling is a key step in malignant progression Duijn, Pedro Marques-Vidal, Peter Vollenweider, Nicholas J. of BRAF-mutant human melanomas Wareham, John B. Whitfield, James Wilson, Bruce Wolffenbuttel, Yinghui Li, Hui Shan Cheng, Wee Joo Chng, Georgy Bakalkin, Evangelos Evangelou, Yun Liu, Kenneth M. Rice, and Vinay Tergaonkar Sylvane Desrivie`res, Steven A. Kliewer, David J. Mangelsdorf, Christian P. Muller, Daniel Levy, and Paul Elliott ¨ MICROBIOLOGY 14408 Zika virus cell tropism in the developing human brain IMMUNOLOGY AND INFLAMMATION and inhibition by azithromycin E8122 Permissive roles of cytokines interleukin-7 and Flt3 Hanna Retallack, Elizabeth Di Lullo, Carolina Arias, Kristeene A. ligand in mouse B-cell lineage commitment Knopp, Matthew T. Laurie, Carmen Sandoval-Espinosa, Lilly von Muenchow, Llucia Alberti-Servera, Fabian Klein, Walter R. Mancia Leon, Robert Krencik, Erik M. Ullian, Julien Giuseppina Capoferri, Daniela Finke, Rhodri Ceredig, Antonius Spatazza, Alex A. Pollen, Caleigh Mandel-Brehm, Tomasz J. Rolink, and Panagiotis Tsapogas Nowakowski, Arnold R. Kriegstein, and Joseph L. DeRisi

vi u www.pnas.org Contents Downloaded by guest on September 28, 2021 NEUROSCIENCE PSYCHOLOGICAL AND COGNITIVE SCIENCES E8169 Stretchable multichannel antennas in soft wireless 14438 Psychopathic individuals exhibit but do not avoid optoelectronic implants for optogenetics regret during counterfactual decision making Sung Il Park, Gunchul Shin, Jordan G. McCall, Ream Al-Hasani, Arielle Baskin-Sommers, Allison M. Stuppy-Sullivan, Aaron Norris, Li Xia, Daniel S. Brenner, Kyung Nim Noh, Sang and Joshua W. Buckholtz Yun Bang, Dionnet L. Bhatti, Kyung-In Jang, Seung-Kyun Kang, 14444 Functional split brain in a driving/listening paradigm Aaron D. Mickle, Gregory Dussor, Theodore J. Price, Robert W. Shuntaro Sasai, Melanie Boly, Armand Mensen, Gereau IV, Michael R. Bruchas, and John A. Rogers and Giulio Tononi E8178 Distinct cortical and striatal actions of a β-arrestin– biased dopamine D2 receptor ligand reveal SUSTAINABILITY SCIENCE unique antipsychotic-like properties ’ Nikhil M. Urs, Steven M. Gee, Thomas F. Pack, John D. McCorvy, 14450 How constraints affect the hunter s decision to shoot Tama Evron, Joshua C. Snyder, Xiaobao Yang, Ramona M. a deer Rodriguiz, Emiliana Borrelli, William C. Wetsel, Jian Jin, Bryan L. Florian K. Diekert, Andries Richter, Inger Maren Rivrud, Roth, Patricio O’Donnell, and Marc G. Caron and Atle Mysterud E8187 Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate SYSTEMS BIOLOGY in cultured cells 14456 High-performance multiplexed fluorescence in situ Amanda L. Woerman, Atsushi Aoyagi, Smita Patel, Sabeen A. hybridization in culture and tissue with matrix Kazmi, Iryna Lobach, Lea T. Grinberg, Ann C. McKee, William W. imprinting and clearing Seeley, Steven H. Olson, and Stanley B. Prusiner Jeffrey R. Moffitt, Junjie Hao, Dhananjay Bambah-Mukku, Tian 14289 Map reading, navigating from maps, and the medial Lu, , and temporal lobe Zhisen J. Urgolites, Soyun Kim, Ramona O. Hopkins, and Larry R. Squire 14414 Exploration of joint redundancy but not task space CORRECTIONS (ONLINE ONLY) variability facilitates supervised motor learning APPLIED PHYSICAL SCIENCES, BIOPHYSICS AND Puneet Singh, Sumitash Jana, Ashitava Ghosal, COMPUTATIONAL BIOLOGY and Aditya Murthy E8207 Red cells’ dynamic morphologies govern blood 14420 Selective lesion of the hippocampus increases the shear thinning under microcirculatory differentiation of immature neurons in the flow conditions monkey amygdala Luca Lanotte, Johannes Mauer, Simon Mendez, Dmitry A. Loı¨c J. Chareyron, David G. Amaral, and Pierre Lavenex Fedosov, Jean-Marc Fromental, Viviana Claveria, Franck Nicoud, Gerhard Gompper, and Manouk Abkarian PHYSIOLOGY 14426 β-Arrestin mediates the Frank–Starling mechanism of cardiac contractility APPLIED PHYSICAL SCIENCES Dennis M. Abraham, Robert T. Davis III, Chad M. Warren, Lan E8208 Self-sustained lift and low friction via soft lubrication Mao, Beata M. Wolska, R. John Solaro, and Howard A. Rockman Baudouin Saintyves, Theo Jules, Thomas Salez, + and L. Mahadevan 14432 Phosphatidylinositol 3-kinase inhibition restores Ca2 release defects and prolongs survival in myotubularin-deficient mice PLANT BIOLOGY Candice Kutchukian, Mirella Lo Scrudato, Yves Tourneur, Karine E8209 Elevated vitamin E content improves all-trans Poulard, Alban Vignaud, Christine Berthier, Bruno Allard, β-carotene accumulation and stability in Michael W. Lawlor, Ana Buj-Bello, and Vincent Jacquemond biofortified sorghum Ping Che, Zuo-Yu Zhao, Kimberly Glassman, David Dolde, Tiger X. PLANT BIOLOGY Hu, Todd J. Jones, Silas Obukosia, Florence Wambugu, E8197 C-terminal domain (CTD) phosphatase links Rho GTPase and Marc C. Albertsen signaling to Pol II CTD phosphorylation in Arabidopsis and yeast Bo Zhang, Guohua Yang, Yu Chen, Yihong Zhao, Peng Gao, Bo Liu, Haiyang Wang, and Zhi-Liang Zheng ix Subscription Form

Contents PNAS u December 13, 2016 u vol. 113 u no. 50 u vii Downloaded by guest on September 28, 2021