The Mtor Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Cellular/Molecular The mTOR substrate S6 Kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for Central Nervous System injury Hassan Al-Ali1,2,3, Ying Ding5,6, Tatiana Slepak1, Wei Wu5, Yan Sun5,7, Yania Martinez1, Xiao-Ming Xu5, V.P. Lemmon1,3 and J.l. Bixby1,3,4 1The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. 2Peggy and Harold Katz Family Drug Discovery Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. 3Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA. 4Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. 5Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. 6Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. 7Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. DOI: 10.1523/JNEUROSCI.0931-17.2017 Received: 4 April 2017 Revised: 18 May 2017 Accepted: 27 May 2017 Published: 16 June 2017 Author contributions: H.A.-A., Y.D., T.S., W.W., Y.S., X.-M.X., V.P.L., and J.B. designed research; H.A.-A., Y.D., T.S., W.W., Y.S., and Y.M.
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