Table S1. Kinase clones included in human kinase cDNA library for yeast two-hybrid screening Gene Symbol Gene Description ACVR1B activin A receptor, type IB ADCK2 aarF domain containing kinase 2 ADCK4 aarF domain containing kinase 4 AGK multiple substrate lipid kinase;MULK AK1 adenylate kinase 1 AK3 adenylate kinase 3 like 1 AK3L1 adenylate kinase 3 ALDH18A1 aldehyde dehydrogenase 18 family, member A1;ALDH18A1 ALK anaplastic lymphoma kinase (Ki-1) ALPK1 alpha-kinase 1 ALPK2 alpha-kinase 2 AMHR2 anti-Mullerian hormone receptor, type II ARAF v-raf murine sarcoma 3611 viral oncogene homolog 1 ARSG arylsulfatase G;ARSG AURKB aurora kinase B AURKC aurora kinase C BCKDK branched chain alpha-ketoacid dehydrogenase kinase BMPR1A bone morphogenetic protein receptor, type IA BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) BRAF v-raf murine sarcoma viral oncogene homolog B1 BRD3 bromodomain containing 3 BRD4 bromodomain containing 4 BTK Bruton agammaglobulinemia tyrosine kinase BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) C9orf98 chromosome 9 open reading frame 98;C9orf98 CABC1 chaperone, ABC1 activity of bc1 complex like (S. pombe) CALM1 calmodulin 1 (phosphorylase kinase, delta) CALM2 calmodulin 2 (phosphorylase kinase, delta) CALM3 calmodulin 3 (phosphorylase kinase, delta) CAMK1 calcium/calmodulin-dependent protein kinase I CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta CAMK4 calcium/calmodulin-dependent protein kinase IV CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) CCL2 chemokine (C-C motif) ligand 2;CCL2 CCL4 chemokine (C-C motif) ligand 4;CCL4 CDK3 cyclin-dependent kinase 3 CDK4 cyclin-dependent kinase 4 CDK5 cyclin-dependent kinase 5 CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) CDKL3 cyclin-dependent kinase-like 3 CDKL4 cyclin-dependent kinase-like 4 CHEK1 CHK1 checkpoint homolog (S. pombe) CIB1 calcium and integrin binding 1 (calmyrin);CIB1 CIB4 calcium and integrin binding family member 4;CIB4 CKB creatine kinase, brain CKM creatine kinase, muscle CKMT1A creatine kinase, mitochondrial 1A;CKMT1A CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) CKS2 CDC28 protein kinase regulatory subunit 2 CLK1 CDC-like kinase 1 CLK2 CDC-like kinase 2 COASY Coenzyme A synthase;COASY CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like;CRKL CSNK1D casein kinase 1, delta CSNK1E casein kinase 1, epsilon CSNK1G1 casein kinase 1, gamma 1 CSNK1G2 casein kinase 1, gamma 2 CSNK1G3 casein kinase 1, gamma 3 CSNK2B casein kinase 2, beta polypeptide DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae);DAK DAPK2 death-associated protein kinase 2 DCAKD dephospho-CoA kinase domain containing;DCAKD DCAMKL2 hypothetical protein MGC45428 DCK deoxycytidine kinase DGKB diacylglycerol kinase, beta 90kDa DGKK diacylglycerol kinase, kappa;DGKK DGUOK deoxyguanosine kinase DLG3 discs, large homolog 3 (neuroendocrine-dlg, Drosophila);DLG3 DTYMK deoxythymidylate kinase (thymidylate kinase) DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 EEF2K eukaryotic elongation factor-2 kinase EPHA2 EPH receptor A2 EPHB1 EPH receptor B1 EPHB6 EPH receptor B6 ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) ERN1 endoplasmic reticulum to nucleus signalling 1 ETNK2 ethanolamine kinase 2 FASTK FAST kinase FASTKD1 FAST kinase domains 1;FASTKD1 FASTKD5 FAST kinase domains 5;FASTKD5 FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) FGFR2 fibroblast growth factor receptor 2 FGFRL1 fibroblast growth factor receptor-like 1;FGFRL1 FGGY hypothetical protein FLJ10986;FLJ10986 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog FLJ23356 hypothetical protein FLJ23356 FLJ25006 hypothetical protein FLJ25006 FLJ40852 hypothetical protein FLJ40852 FLT3 fms-related tyrosine kinase 3 FN3K fructosamine 3 kinase FXN frataxin;FXN GALK1 galactokinase 1 GALK2 galactokinase 2 GRK7 G protein-coupled receptor kinase 7 GSK3A glycogen synthase kinase 3 alpha GSK3B glycogen synthase kinase 3 beta GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa;GTF2H1 HCK hemopoietic cell kinase HIPK1 homeodomain interacting protein kinase 1 HIPK3 homeodomain interacting protein kinase 3 HIPK4 homeodomain interacting protein kinase 4 IHPK3 inositol hexaphosphate kinase 3 IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon INSRR insulin receptor-related receptor IRAK2 interleukin-1 receptor-associated kinase 2 IRAK4 interleukin-1 receptor-associated kinase 4 ITGB1BP3 integrin beta 1 binding protein 3;ITGB1BP3 ITPKB inositol 1,4,5-trisphosphate 3-kinase B KHK ketohexokinase (fructokinase) KSR2 kinase suppressor of Ras-2 LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) LIMK1 LIM domain kinase 1 LOC388957 similar to BMP2 inducible kinase LOC389599 similar to amyotrophic lateral sclerosis 2 chromosome region LOC54103 hypothetical protein LOC54103;LOC54103 LOC646505 similar to Dual specificity protein kinase CLK3 (CDC-like kinase 3) LOC647279 similar to MAP/microtubule affinity-regulating kinase 3 LOC648152 similar to ataxia telangiectasia and Rad3 related protein LOC652799 similar to Mast/stem cell growth factor receptor precursor (SCFR) LOC653052 similar to Homeodomain-interacting protein kinase 2 (hHIPk2) LOC653155 similar to PRP4 pre-mRNA processing factor 4 homolog B LOC727761 similar to deoxythymidylate kinase (thymidylate kinase) LOC732306 similar to vaccinia related kinase 2 LOC91461 hypothetical protein BC007901 LRGUK leucine-rich repeats and guanylate kinase domain containing;LRGUK LRPPRC leucine-rich PPR-motif containing;LRPPRC LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog MAK male germ cell-associated kinase MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1 MAP2K2 mitogen-activated protein kinase kinase 2 MAP2K5 mitogen-activated protein kinase kinase 5 MAP2K6 mitogen-activated protein kinase kinase 6 MAP3K11 mitogen-activated protein kinase kinase kinase 11 MAP3K14 mitogen-activated protein kinase kinase kinase 14 MAP3K2 mitogen-activated protein kinase kinase kinase 2 MAP3K6 mitogen-activated protein kinase kinase kinase 6 MAP3K8 mitogen-activated protein kinase kinase kinase 8 MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 MAPK1 mitogen-activated protein kinase 1 MAPK12 mitogen-activated protein kinase 12 MAPK13 mitogen-activated protein kinase 13 MAPK14 mitogen-activated protein kinase 14;p38 MAPK3 mitogen-activated protein kinase 3 MAPK6 mitogen-activated protein kinase 6 MAPK9 mitogen-activated protein kinase 9 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 MARK2 MAP/microtubule affinity-regulating kinase 2 MARK3 MAP/microtubule affinity-regulating kinase 3 MAST2 microtubule associated serine/threonine kinase 2 MASTL microtubule associated serine/threonine kinase-like MATK megakaryocyte-associated tyrosine kinase MET met proto-oncogene (hepatocyte growth factor receptor) MGC16169 hypothetical protein MGC16169 MINK1 misshapen/NIK-related kinase MKNK1 MAP kinase interacting serine/threonine kinase 1 MKNK2 MAP kinase interacting serine/threonine kinase 2 MORN2 MORN repeat containing 2;MORN2 MOS v-mos Moloney murine sarcoma viral oncogene homolog MPP1 membrane protein, palmitoylated 1, 55kDa;MPP1 MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2);MPP2 MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3);MPP3 MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5);MPP5 MVK mevalonate kinase (mevalonic aciduria) MYLK3 myosin light chain kinase (MLCK) NADK NAD kinase NEK11 NIMA (never in mitosis gene a)- related kinase 11 NEK2 NIMA (never in mitosis gene a)-related kinase 2 NEK3 NIMA (never in mitosis gene a)-related kinase 3 NEK8 NIMA (never in mitosis gene a)- related kinase 8 NEK9 NIMA (never in mitosis gene a)- related kinase 9 NME1 nucleoside-diphosphate kinase 1 NME1-NME2 NME1-NME2 protein;NME1-NME2 NME2 nucleoside-diphosphate kinase 2 NME6 non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) NME7 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) NRBP nuclear receptor binding protein NUP62 nucleoporin 62kDa;NUP62 NYD-SP25 protein kinase NYD-SP25 PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) PAK7 p21(CDKN1A)-activated kinase 7 PANK2 pantothenate kinase 2 (Hallervorden-Spatz syndrome) PANK3 pantothenate kinase 3 PANK4 pantothenate kinase 4 PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2;PAPSS2 PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) PDIK1L PDLIM1 interacting kinase 1 like PDK1 pyruvate dehydrogenase kinase, isoenzyme 1 PDK2 pyruvate dehydrogenase kinase, isoenzyme 2 PDK3 pyruvate dehydrogenase kinase, isoenzyme 3 PDK4 pyruvate dehydrogenase kinase, isoenzyme 4 PDXK pyridoxal (pyridoxine, vitamin B6) kinase PFKL phosphofructokinase, liver PFKM phosphofructokinase, muscle PFKP phosphofructokinase, platelet PHKG1 phosphorylase kinase, gamma 1 (muscle) PHKG2 phosphorylase kinase, gamma 2 (testis) PI4K2B phosphatidylinositol 4-kinase type-II beta PI4KII phosphatidylinositol 4-kinase type II PIK3C3 phosphoinositide-3-kinase, class 3 PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4, p150 PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide PIK4CB phosphatidylinositol 4-kinase, catalytic, beta polypeptide PIM1 pim-1 oncogene PINK1 PTEN induced putative kinase 1 PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha PIP5K2C phosphatidylinositol-4-phosphate 5-kinase, type II, gamma PIP5K3 phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III PKLR pyruvate kinase, liver and RBC PKMYT1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PLAU plasminogen activator, urokinase PLK1 polo-like kinase 1 (Drosophila) PLXNA3 plexin A3;PLXNA3 PLXNB2 plexin B2;PLXNB2 PMVK phosphomevalonate kinase PNKP polynucleotide kinase 3'-phosphatase PRKACA protein kinase, cAMP-dependent, catalytic, alpha PRKACB protein kinase, cAMP-dependent, catalytic, beta PRKACG protein kinase, cAMP-dependent, catalytic, gamma PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher PRKAR1A 1) PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta PRKCB1 protein kinase C, beta 1 PRKCE protein kinase C, epsilon PRKCQ protein kinase C, theta PRKCZ protein kinase C, zeta PRKD1 protein kinase D1 PRKD2 protein kinase D2 PRKG1 protein kinase, cGMP-dependent, type I PRKR protein kinase, interferon-inducible double stranded RNA dependent PRKX protein kinase, X-linked PRKY protein kinase, Y-linked PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast) PRPS1 phosphoribosyl pyrophosphate synthetase 1;PRPS1 PRPS2 phosphoribosyl pyrophosphate synthetase 2;PRPS2 PSKH1 protein serine kinase H1 PTK6 PTK6 protein tyrosine kinase 6 PXK PX domain containing serine/threonine kinase RIOK1 RIO kinase 1 (yeast) RIOK3 RIO kinase 3 (yeast) RKHD3 ring finger and KH domain containing 3;RKHD3 ROR2 receptor tyrosine kinase-like orphan receptor 2 RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 SCYL2 hypothetical protein FLJ10074 SCYL3 ezrin-binding partner PACE-1 SGK serum/glucocorticoid regulated kinase SGK3 serum/glucocorticoid regulated kinase-like SH3BP5L SH3-binding domain protein 5-like;SH3BP5L SLAMF6 SLAM family member 6;SLAMF6 SPHK1 sphingosine kinase 1 SPHK2 sphingosine kinase 2 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRPK1 SFRS protein kinase 1 SRPK2 SFRS protein kinase 2 STK16 serine/threonine kinase 16 STK17B serine/threonine kinase 17b (apoptosis-inducing) STK3 serine/threonine kinase 3 (STE20 homolog, yeast) STK32A serine/threonine kinase 32A STK32C serine/threonine kinase 32C STK33 serine/threonine kinase 33 STK40 Ser/Thr-like kinase STYK1 protein kinase STYK1 SYK spleen tyrosine kinase TAOK3 TAO kinase 3 TEC tec protein tyrosine kinase TESK1 testis-specific kinase 1 TESK2 testis-specific kinase 2 TGFBR3 transforming growth factor, beta receptor III (betaglycan, 300kDa);TGFBR3 TK1 thymidine kinase 1, soluble TLK1 tousled-like kinase 1 TP53RK TP53 regulating kinase TRIB1 tribbles homolog 1 (Drosophila) TRIB2 tribbles homolog 2 (Drosophila) TSSK1 serine/threonine kinase 22D (spermiogenesis associated) TSSK3 serine/threonine kinase 22C (spermiogenesis associated) TTK TTK protein kinase TXK TXK tyrosine kinase TXNDC3 thioredoxin domain containing 3 (spermatozoa);TXNDC3 TYK2 tyrosine kinase 2 ULK2 unc-51-like kinase 2 (C. elegans) VRK1 vaccinia related kinase 1 WNK1 protein kinase, lysine deficient 1 WNK4 protein kinase, lysine deficient 4 ZAK sterile alpha motif and leucine zipper containing kinase AZK ZAP70 zeta-chain (TCR) associated protein kinase 70kDa