<p><strong>Table S1. Kinase clones included in human kinase cDNA library for yeast two-hybrid screening </strong></p><p><strong>Gene Symbol </strong></p><p>ACVR1B ADCK2 ADCK4 AGK </p><p><strong>Gene Description </strong></p><p>activin A receptor, type IB aarF domain containing kinase 2 aarF domain containing kinase 4 multiple substrate lipid kinase;MULK </p><ul style="display: flex;"><li style="flex:1">AK1 </li><li style="flex:1">adenylate kinase 1 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">AK3 </li><li style="flex:1">adenylate kinase 3 like 1 </li></ul><p>AK3L1 ALDH18A1 ALK adenylate kinase 3 aldehyde dehydrogenase 18 family, member A1;ALDH18A1 anaplastic lymphoma kinase (Ki-1) <br>ALPK1 ALPK2 AMHR2 ARAF alpha-kinase 1 alpha-kinase 2 anti-Mullerian hormone receptor, type II v-raf murine sarcoma 3611 viral oncogene homolog 1 </p><ul style="display: flex;"><li style="flex:1">arylsulfatase G;ARSG </li><li style="flex:1">ARSG </li></ul><p>AURKB AURKC BCKDK BMPR1A BMPR2 BRAF aurora kinase B aurora kinase C branched chain alpha-ketoacid dehydrogenase kinase bone morphogenetic protein receptor, type IA bone morphogenetic protein receptor, type II (serine/threonine kinase) v-raf murine sarcoma viral oncogene homolog B1 </p><ul style="display: flex;"><li style="flex:1">bromodomain containing 3 </li><li style="flex:1">BRD3 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">BRD4 </li><li style="flex:1">bromodomain containing 4 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">BTK </li><li style="flex:1">Bruton agammaglobulinemia tyrosine kinase </li></ul><p>BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) chromosome 9 open reading frame 98;C9orf98 chaperone, ABC1 activity of bc1 complex like (S. pombe) calmodulin 1 (phosphorylase kinase, delta) calmodulin 2 (phosphorylase kinase, delta) calmodulin 3 (phosphorylase kinase, delta) calcium/calmodulin-dependent protein kinase I calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha calcium/calmodulin-dependent protein kinase (CaM kinase) II beta calcium/calmodulin-dependent protein kinase IV calcium/calmodulin-dependent serine protein kinase (MAGUK family) chemokine (C-C motif) ligand 2;CCL2 chemokine (C-C motif) ligand 4;CCL4 cyclin-dependent kinase 3 <br>BUB1 BUB1B C9orf98 CABC1 CALM1 CALM2 CALM3 CAMK1 CAMK2A CAMK2B CAMK4 CASK CCL2 CCL4 CDK3 </p><ul style="display: flex;"><li style="flex:1">CDK4 </li><li style="flex:1">cyclin-dependent kinase 4 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">CDK5 </li><li style="flex:1">cyclin-dependent kinase 5 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">CDK5R1 </li><li style="flex:1">cyclin-dependent kinase 5, regulatory subunit 1 (p35) </li></ul><p></p><ul style="display: flex;"><li style="flex:1">CDK7 </li><li style="flex:1">cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) </li></ul><p></p><ul style="display: flex;"><li style="flex:1">cyclin-dependent kinase-like 3 </li><li style="flex:1">CDKL3 </li></ul><p>CDKL4 CHEK1 CIB1 cyclin-dependent kinase-like 4 CHK1 checkpoint homolog (S. pombe) calcium and integrin binding 1 (calmyrin);CIB1 calcium and integrin binding family member 4;CIB4 creatine kinase, brain <br>CIB4 CKB </p><ul style="display: flex;"><li style="flex:1">CKM </li><li style="flex:1">creatine kinase, muscle </li></ul><p>CKMT1A CKMT2 CKS2 creatine kinase, mitochondrial 1A;CKMT1A creatine kinase, mitochondrial 2 (sarcomeric) CDC28 protein kinase regulatory subunit 2 </p><ul style="display: flex;"><li style="flex:1">CDC-like kinase 1 </li><li style="flex:1">CLK1 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">CLK2 </li><li style="flex:1">CDC-like kinase 2 </li></ul><p>COASY CRKL <br>Coenzyme A synthase;COASY v-crk sarcoma virus CT10 oncogene homolog (avian)-like;CRKL </p><ul style="display: flex;"><li style="flex:1">casein kinase 1, delta </li><li style="flex:1">CSNK1D </li></ul><p>CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2B DAK casein kinase 1, epsilon casein kinase 1, gamma 1 casein kinase 1, gamma 2 casein kinase 1, gamma 3 casein kinase 2, beta polypeptide dihydroxyacetone kinase 2 homolog (S. cerevisiae);DAK </p><ul style="display: flex;"><li style="flex:1">death-associated protein kinase 2 </li><li style="flex:1">DAPK2 </li></ul><p>DCAKD DCAMKL2 DCK dephospho-CoA kinase domain containing;DCAKD hypothetical protein MGC45428 deoxycytidine kinase </p><ul style="display: flex;"><li style="flex:1">DGKB </li><li style="flex:1">diacylglycerol kinase, beta 90kDa </li></ul><p></p><ul style="display: flex;"><li style="flex:1">DGKK </li><li style="flex:1">diacylglycerol kinase, kappa;DGKK </li></ul><p></p><ul style="display: flex;"><li style="flex:1">deoxyguanosine kinase </li><li style="flex:1">DGUOK </li></ul><p></p><ul style="display: flex;"><li style="flex:1">DLG3 </li><li style="flex:1">discs, large homolog 3 (neuroendocrine-dlg, Drosophila);DLG3 </li></ul><p>deoxythymidylate kinase (thymidylate kinase) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 eukaryotic elongation factor-2 kinase EPH receptor A2 <br>DTYMK DYRK1B DYRK2 EEF2K EPHA2 EPHB1 EPHB6 ERBB2 ERBB3 ERBB4 ERN1 <br>EPH receptor B1 EPH receptor B6 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) endoplasmic reticulum to nucleus signalling 1 </p><ul style="display: flex;"><li style="flex:1">ethanolamine kinase 2 </li><li style="flex:1">ETNK2 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">FASTK </li><li style="flex:1">FAST kinase </li></ul><p>FASTKD1 FASTKD5 FER <br>FAST kinase domains 1;FASTKD1 FAST kinase domains 5;FASTKD5 fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) </p><ul style="display: flex;"><li style="flex:1">fibroblast growth factor receptor 2 </li><li style="flex:1">FGFR2 </li></ul><p>FGFRL1 FGGY fibroblast growth factor receptor-like 1;FGFRL1 hypothetical protein FLJ10986;FLJ10986 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog hypothetical protein FLJ23356 <br>FGR FLJ23356 FLJ25006 FLJ40852 FLT3 hypothetical protein FLJ25006 hypothetical protein FLJ40852 fms-related tyrosine kinase 3 </p><ul style="display: flex;"><li style="flex:1">FN3K </li><li style="flex:1">fructosamine 3 kinase </li></ul><p></p><ul style="display: flex;"><li style="flex:1">FXN </li><li style="flex:1">frataxin;FXN </li></ul><p>GALK1 GALK2 GRK7 galactokinase 1 galactokinase 2 G protein-coupled receptor kinase 7 <br>GSK3A GSK3B glycogen synthase kinase 3 alpha glycogen synthase kinase 3 beta <br>GTF2H1 HCK general transcription factor IIH, polypeptide 1, 62kDa;GTF2H1 hemopoietic cell kinase </p><ul style="display: flex;"><li style="flex:1">HIPK1 </li><li style="flex:1">homeodomain interacting protein kinase 1 </li></ul><p>homeodomain interacting protein kinase 3 homeodomain interacting protein kinase 4 inositol hexaphosphate kinase 3 <br>HIPK3 HIPK4 IHPK3 </p><ul style="display: flex;"><li style="flex:1">IKBKE </li><li style="flex:1">inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon </li></ul><p></p><ul style="display: flex;"><li style="flex:1">insulin receptor-related receptor </li><li style="flex:1">INSRR </li></ul><p></p><ul style="display: flex;"><li style="flex:1">IRAK2 </li><li style="flex:1">interleukin-1 receptor-associated kinase 2 </li></ul><p>interleukin-1 receptor-associated kinase 4 integrin beta 1 binding protein 3;ITGB1BP3 inositol 1,4,5-trisphosphate 3-kinase B ketohexokinase (fructokinase) <br>IRAK4 ITGB1BP3 ITPKB KHK </p><ul style="display: flex;"><li style="flex:1">KSR2 </li><li style="flex:1">kinase suppressor of Ras-2 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">LATS1 </li><li style="flex:1">LATS, large tumor suppressor, homolog 1 (Drosophila) </li></ul><p></p><ul style="display: flex;"><li style="flex:1">LIM domain kinase 1 </li><li style="flex:1">LIMK1 </li></ul><p>LOC388957 LOC389599 LOC54103 LOC646505 LOC647279 LOC648152 LOC652799 LOC653052 LOC653155 similar to BMP2 inducible kinase similar to amyotrophic lateral sclerosis 2 chromosome region hypothetical protein LOC54103;LOC54103 similar to Dual specificity protein kinase CLK3 (CDC-like kinase 3) similar to MAP/microtubule affinity-regulating kinase 3 similar to ataxia telangiectasia and Rad3 related protein similar to Mast/stem cell growth factor receptor precursor (SCFR) similar to Homeodomain-interacting protein kinase 2 (hHIPk2) similar to PRP4 pre-mRNA processing factor 4 homolog B <br>LOC727761 LOC732306 LOC91461 LRGUK LRPPRC LYN similar to deoxythymidylate kinase (thymidylate kinase) similar to vaccinia related kinase 2 hypothetical protein BC007901 leucine-rich repeats and guanylate kinase domain containing;LRGUK leucine-rich PPR-motif containing;LRPPRC v-yes-1 Yamaguchi sarcoma viral related oncogene homolog </p><ul style="display: flex;"><li style="flex:1">male germ cell-associated kinase </li><li style="flex:1">MAK </li></ul><p>MAP2K1 MAP2K1IP1 MAP2K2 MAP2K5 MAP2K6 MAP3K11 MAP3K14 MAP3K2 MAP3K6 MAP3K8 MAP4K1 MAP4K5 MAPK1 MAPK12 MAPK13 MAPK14 MAPK3 MAPK6 MAPK9 MAPKAPK2 MARK2 MARK3 MAST2 MASTL MATK mitogen-activated protein kinase kinase 1 mitogen-activated protein kinase kinase 1 interacting protein 1 mitogen-activated protein kinase kinase 2 mitogen-activated protein kinase kinase 5 mitogen-activated protein kinase kinase 6 mitogen-activated protein kinase kinase kinase 11 mitogen-activated protein kinase kinase kinase 14 mitogen-activated protein kinase kinase kinase 2 mitogen-activated protein kinase kinase kinase 6 mitogen-activated protein kinase kinase kinase 8 mitogen-activated protein kinase kinase kinase kinase 1 mitogen-activated protein kinase kinase kinase kinase 5 mitogen-activated protein kinase 1 mitogen-activated protein kinase 12 mitogen-activated protein kinase 13 mitogen-activated protein kinase 14;p38 mitogen-activated protein kinase 3 mitogen-activated protein kinase 6 mitogen-activated protein kinase 9 mitogen-activated protein kinase-activated protein kinase 2 MAP/microtubule affinity-regulating kinase 2 MAP/microtubule affinity-regulating kinase 3 microtubule associated serine/threonine kinase 2 microtubule associated serine/threonine kinase-like megakaryocyte-associated tyrosine kinase </p><ul style="display: flex;"><li style="flex:1">MET </li><li style="flex:1">met proto-oncogene (hepatocyte growth factor receptor) </li></ul><p></p><ul style="display: flex;"><li style="flex:1">hypothetical protein MGC16169 </li><li style="flex:1">MGC16169 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">MINK1 </li><li style="flex:1">misshapen/NIK-related kinase </li></ul><p>MKNK1 MKNK2 MORN2 MOS <br>MAP kinase interacting serine/threonine kinase 1 MAP kinase interacting serine/threonine kinase 2 MORN repeat containing 2;MORN2 v-mos Moloney murine sarcoma viral oncogene homolog membrane protein, palmitoylated 1, 55kDa;MPP1 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2);MPP2 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3);MPP3 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5);MPP5 <br>MPP1 MPP2 MPP3 MPP5 </p><ul style="display: flex;"><li style="flex:1">MVK </li><li style="flex:1">mevalonate kinase (mevalonic aciduria) </li></ul><p></p><ul style="display: flex;"><li style="flex:1">myosin light chain kinase (MLCK) </li><li style="flex:1">MYLK3 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">NADK </li><li style="flex:1">NAD kinase </li></ul><p>NEK11 NEK2 <br>NIMA (never in mitosis gene a)- related kinase 11 NIMA (never in mitosis gene a)-related kinase 2 NIMA (never in mitosis gene a)-related kinase 3 NIMA (never in mitosis gene a)- related kinase 8 NIMA (never in mitosis gene a)- related kinase 9 nucleoside-diphosphate kinase 1 <br>NEK3 NEK8 NEK9 NME1 NME1-NME2 NME2 <br>NME1-NME2 protein;NME1-NME2 nucleoside-diphosphate kinase 2 </p><ul style="display: flex;"><li style="flex:1">NME6 </li><li style="flex:1">non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) </li></ul><p>non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) nuclear receptor binding protein <br>NME7 NRBP NUP62 NYD-SP25 PAK1 nucleoporin 62kDa;NUP62 protein kinase NYD-SP25 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) </p><ul style="display: flex;"><li style="flex:1">p21(CDKN1A)-activated kinase 7 </li><li style="flex:1">PAK7 </li></ul><p>PANK2 PANK3 PANK4 PAPSS2 PCK2 pantothenate kinase 2 (Hallervorden-Spatz syndrome) pantothenate kinase 3 pantothenate kinase 4 3'-phosphoadenosine 5'-phosphosulfate synthase 2;PAPSS2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) </p><ul style="display: flex;"><li style="flex:1">PDLIM1 interacting kinase 1 like </li><li style="flex:1">PDIK1L </li></ul><p></p><ul style="display: flex;"><li style="flex:1">PDK1 </li><li style="flex:1">pyruvate dehydrogenase kinase, isoenzyme 1 </li></ul><p>pyruvate dehydrogenase kinase, isoenzyme 2 pyruvate dehydrogenase kinase, isoenzyme 3 pyruvate dehydrogenase kinase, isoenzyme 4 pyridoxal (pyridoxine, vitamin B6) kinase phosphofructokinase, liver <br>PDK2 PDK3 PDK4 PDXK PFKL </p><ul style="display: flex;"><li style="flex:1">PFKM </li><li style="flex:1">phosphofructokinase, muscle </li></ul><p></p><ul style="display: flex;"><li style="flex:1">PFKP </li><li style="flex:1">phosphofructokinase, platelet </li></ul><p>PHKG1 PHKG2 PI4K2B PI4KII phosphorylase kinase, gamma 1 (muscle) phosphorylase kinase, gamma 2 (testis) phosphatidylinositol 4-kinase type-II beta phosphatidylinositol 4-kinase type II <br>PIK3C3 PIK3CB PIK3CG PIK3R4 PIK4CA PIK4CB PIM1 phosphoinositide-3-kinase, class 3 phosphoinositide-3-kinase, catalytic, beta polypeptide phosphoinositide-3-kinase, catalytic, gamma polypeptide phosphoinositide-3-kinase, regulatory subunit 4, p150 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide phosphatidylinositol 4-kinase, catalytic, beta polypeptide pim-1 oncogene </p><ul style="display: flex;"><li style="flex:1">PINK1 </li><li style="flex:1">PTEN induced putative kinase 1 </li></ul><p>PIP5K1B PIP5K2A PIP5K2C PIP5K3 PKLR phosphatidylinositol-4-phosphate 5-kinase, type I, beta phosphatidylinositol-4-phosphate 5-kinase, type II, alpha phosphatidylinositol-4-phosphate 5-kinase, type II, gamma phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III pyruvate kinase, liver and RBC <br>PKMYT1 PLAU membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase plasminogen activator, urokinase </p><ul style="display: flex;"><li style="flex:1">PLK1 </li><li style="flex:1">polo-like kinase 1 (Drosophila) </li></ul><p>PLXNA3 PLXNB2 PMVK plexin A3;PLXNA3 plexin B2;PLXNB2 phosphomevalonate kinase </p><ul style="display: flex;"><li style="flex:1">PNKP </li><li style="flex:1">polynucleotide kinase 3'-phosphatase </li></ul><p>PRKACA PRKACB PRKACG PRKAG2 PRKAG3 protein kinase, cAMP-dependent, catalytic, alpha protein kinase, cAMP-dependent, catalytic, beta protein kinase, cAMP-dependent, catalytic, gamma protein kinase, AMP-activated, gamma 2 non-catalytic subunit protein kinase, AMP-activated, gamma 3 non-catalytic subunit protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher </p><ul style="display: flex;"><li style="flex:1">1) </li><li style="flex:1">PRKAR1A </li></ul><p>PRKAR1B PRKAR2B PRKCB1 PRKCE PRKCQ PRKCZ PRKD1 PRKD2 PRKG1 PRKR protein kinase, cAMP-dependent, regulatory, type I, beta protein kinase, cAMP-dependent, regulatory, type II, beta protein kinase C, beta 1 protein kinase C, epsilon protein kinase C, theta protein kinase C, zeta protein kinase D1 protein kinase D2 protein kinase, cGMP-dependent, type I protein kinase, interferon-inducible double stranded RNA dependent </p><ul style="display: flex;"><li style="flex:1">protein kinase, X-linked </li><li style="flex:1">PRKX </li></ul><p></p><ul style="display: flex;"><li style="flex:1">PRKY </li><li style="flex:1">protein kinase, Y-linked </li></ul><p>PRPF4B PRPS1 PRPS2 PSKH1 PTK6 <br>PRP4 pre-mRNA processing factor 4 homolog B (yeast) phosphoribosyl pyrophosphate synthetase 1;PRPS1 phosphoribosyl pyrophosphate synthetase 2;PRPS2 protein serine kinase H1 PTK6 protein tyrosine kinase 6 </p><ul style="display: flex;"><li style="flex:1">PXK </li><li style="flex:1">PX domain containing serine/threonine kinase </li></ul><p></p><ul style="display: flex;"><li style="flex:1">RIO kinase 1 (yeast) </li><li style="flex:1">RIOK1 </li></ul><p></p><ul style="display: flex;"><li style="flex:1">RIOK3 </li><li style="flex:1">RIO kinase 3 (yeast) </li></ul><p>RKHD3 ROR2 ring finger and KH domain containing 3;RKHD3 receptor tyrosine kinase-like orphan receptor 2 ribosomal protein S6 kinase, 90kDa, polypeptide 1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 <br>RPS6KA1 RPS6KB1 RPS6KB2 SCYL2 SCYL3 SGK ribosomal protein S6 kinase, 70kDa, polypeptide 2 hypothetical protein FLJ10074 ezrin-binding partner PACE-1 serum/glucocorticoid regulated kinase serum/glucocorticoid regulated kinase-like SH3-binding domain protein 5-like;SH3BP5L SLAM family member 6;SLAMF6 sphingosine kinase 1 <br>SGK3 SH3BP5L SLAMF6 SPHK1 SPHK2 SRC sphingosine kinase 2 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) </p><ul style="display: flex;"><li style="flex:1">SFRS protein kinase 1 </li><li style="flex:1">SRPK1 </li></ul><p>SRPK2 STK16 STK17B STK3 <br>SFRS protein kinase 2 serine/threonine kinase 16 serine/threonine kinase 17b (apoptosis-inducing) serine/threonine kinase 3 (STE20 homolog, yeast) </p><ul style="display: flex;"><li style="flex:1">serine/threonine kinase 32A </li><li style="flex:1">STK32A </li></ul><p>STK32C STK33 STK40 STYK1 SYK serine/threonine kinase 32C serine/threonine kinase 33 Ser/Thr-like kinase protein kinase STYK1 spleen tyrosine kinase <br>TAOK3 TEC <br>TAO kinase 3 tec protein tyrosine kinase <br>TESK1 TESK2 TGFBR3 TK1 testis-specific kinase 1 testis-specific kinase 2 transforming growth factor, beta receptor III (betaglycan, 300kDa);TGFBR3 thymidine kinase 1, soluble </p><ul style="display: flex;"><li style="flex:1">TLK1 </li><li style="flex:1">tousled-like kinase 1 </li></ul><p>TP53RK TRIB1 TRIB2 TSSK1 TSSK3 TTK <br>TP53 regulating kinase tribbles homolog 1 (Drosophila) tribbles homolog 2 (Drosophila) serine/threonine kinase 22D (spermiogenesis associated) serine/threonine kinase 22C (spermiogenesis associated) TTK protein kinase </p><ul style="display: flex;"><li style="flex:1">TXK </li><li style="flex:1">TXK tyrosine kinase </li></ul><p>TXNDC3 TYK2 thioredoxin domain containing 3 (spermatozoa);TXNDC3 tyrosine kinase 2 </p><ul style="display: flex;"><li style="flex:1">ULK2 </li><li style="flex:1">unc-51-like kinase 2 (C. elegans) </li></ul><p></p><ul style="display: flex;"><li style="flex:1">vaccinia related kinase 1 </li><li style="flex:1">VRK1 </li></ul><p>WNK1 WNK4 ZAK protein kinase, lysine deficient 1 protein kinase, lysine deficient 4 sterile alpha motif and leucine zipper containing kinase AZK </p><ul style="display: flex;"><li style="flex:1">zeta-chain (TCR) associated protein kinase 70kDa </li><li style="flex:1">ZAP70 </li></ul><p></p>