Profile of Philip Hieter PROFILE
PROFILE Profile of Philip Hieter PROFILE Paul Gabrielsen, Science Writer To bakers, yeast is important for leavening dough. To geneticist Philip Hieter, yeast can help unravel human disease. Hieter, a professor at the University of British Columbia’s Michael Smith Laboratories and member of the National Academy of Sciences, believes that model organisms, such as yeast, represent the future of genetics, as discoveries made using such organisms are increasingly linked to human disorders. Hieter, born in 1952, grew up in Garden City, New York, with two older brothers and an older sister. As an undergraduate at The Johns Hopkins University in the early 1970s, Hieter worked in the laboratory of Carl Levy, who worked to isolate ribonuclease en- zymes from soil in an early effort at RNA sequencing. A year after graduating, Hieter attended a semi- nar given by Philip Leder, a molecular biologist at the National Institutes of Health in Bethesda, Maryland. Leder and his colleagues had just cloned mouse antibody genes using bacteriophage cloning vectors, and were studying the phenomenon of genetic recom- bination that endows the immune system with a rich array of antibodies. “The talk blew my mind,” Hieter says. Inspired, Hieter arranged to work as a graduate student in Leder’s laboratory. Mentored by postdoc- “ ” toral scholar John Seidman ( a wizard, Hieter says), Philip Hieter. Image courtesy of Philip Hieter. Hieter cloned the κ and λ light-chain genes that en- code human antibodies. “Cloning the first gene took “ forever,” Hieter says, but once he cloned the κ gene native, he was impressed with his new setting.
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