Spot on Biotechnology Business 2019/2020 There Wants to Improve on Its Strengths, and Systematically Strive for Excellence in NRW

www.wirtschaft.nrw 40213 Düsseldorf of NorthRhine-Westphalia Digitalization andEnergy of theState Ministry of Economic Affairs, Innovation, www.bio.nrw.de [email protected] Fax Fon 40225 Düsseldorf, Germany Merowingerplatz 1 BIO.NRW +49 211385469-9220 +49 211385469-9200

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www.bio.nrw.de Spot onBiotechnology Business 2019/2020

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From Mind to Market: Biotechnology Company Directory 2019/2020 North Rhine-Westphalia BIO.NRW

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Editorial

Dear Reader, industry towards a comprehensive and sustainable bio-based economy – a highly North Rhine-Westphalia is a vibrant indus- relevant process in North Rhine-Westphalia trial and scientific location. Being at the in the years to come. This development goes center of Europe, the federal state exhibits along with societal changes and the need Germany’s densest network of universi- for information and discussion. The Federal ties and research institutes. At the same Government recognizes the central impor- time, it is a traditional location for the tance of bioeconomy as well and makes it chemistry and pharmaceuticals industry. the topic of the annual “Year of Science” Benefiting from the location advantage in 2020, aiming at the communication and the biotechnology industry could thrive in interaction between science and society. North Rhine-Westphalia. In order to pro- Biologization and digitalization belong to mote North Rhine-Westphalia’s role as a the greatest tasks of our time. I am pleased leading biotech location the state govern- that “BIO.NRW” continues to tackle these ment started ”BIO.NRW” 10 years ago to challenges by initiating collaborations bring together the different stakeholders between science, industry, investors and in the field of biotechnology. Since then the politics. With this, I would like to congratu- biotech industry in North Rhine-Westphalia late to 10 years of advancing North Rhine- has been constantly growing. With the sup- Westphalia as the top biotechnology loca- port of “BIO.NRW” mediating access to the tion and I am looking forward to the coming several funding and investment programs, years of inspiring networking. launched by the state of North Rhine- Westphalia as well as international markets, dozens of start-ups have been founded. They bring new biotechnological innovations Examples are digital biomarkers, next gen- into the market and further promote North eration sequencing and synthetic biology. Rhine-Westphalia’s economy. North Rhine- Biotechnology can be applied in all industry Westphalia is a truly international business sectors which is why biotech innovations location with the highest number of foreign contribute substantially to the process company subsidiaries in Germany. “BIO. of “biologization of industry”, building a Prof Dr Andreas Pinkwart NRW” strategically develops internation- sustainable bioeconomy. Starting from alization of the life sciences on the most the medicine sector bio-based processes Minister of Economic Affairs, Innovation, important global markets, with China being spread into all industry sectors by now. Digitalization and Energy of the State of a focus in recent years. Therefore, biotechnology and digitaliza- North Rhine-Westphalia Together, this growth also supports Ger- tion are both important pace setters for many as a European biotech region, which future innovations and industrial progress. was recently ranked by the US journal GEN Both contribute to achieve e.g. personal- as one of the top bio-pharma locations in ized medicine and allow the optimization Europe. of industrial processes. This innovative Biotechnological methods experience a development can provide solutions amidst rapid growth, boosted even further through pressing challenges like climate change or the combination with digital technologies. the structural change from the coal mining

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Greeting

Dear Reader,

The team of BIO.NRW is proud to present tural change mainly affects the region called the 10 years anniversary edition of “Spot “Rheinisches Revier”, which has turned into on Biotechnology Business”. On this occa- a major industrial location due to lignite sion we would like to take a closer look on mining over the past decades. The value 10 years of growth for the biotechnology created directly or indirectly by the lignite industry sectors in North Rhine-Westphalia: mining industry resulted in prosperity of 2009, the biotech industry was already the “Rheinisches Revier” and the adjacent regarded being a key technology of the regions. 21th century. This modern and innovative Reshaping a whole region from a fossil- industry had experienced a rapid growth based into a sustainable economic system since its emergence 30 years ago. Especially is a major challenge. In this context, the bio- North Rhine-Westphalia had developed into based economy offers the possibility to en- the regions that have to undergo an all-em- a biotech hot spot region certainly within sure prosperity, employment and economic bracing structural change could therefore Germany but also in Europe. The positive growth. The transition is not restricted to the become a model region for Europe in terms growth has continued over the last 10 energy sector, bioeconomy rather impacts of implementing a bioeconomy and turning years. The numbers of dedicated biotech on all economic sectors. Examples for prom- from a highly fossil-depended region to a companies and their employees have almost ising bioeconomy concepts are biorefiner- sustainable and future-orientated region. doubled during that time. Back then as well ies, waste water treatment by microalgae or The next 10 years for sure will show how as today – among the different areas of the production of bioplastics by microorgan- this transformation takes place and we will application of biotech – the health sector isms. Importantly, also pharma and health keep track and support of these exciting is the most prominent segment in North as NRW’s largest industry sectors are in- developments! Rhine-Westphalia as most companies are creasingly depended on biotech innovations For now, feel free to take a detailed active in that field. The areas of industrial and are thus accounted as a major part of a look into NRW’s biotech industry and the biotechnology and agrobiotechnology were knowledge-driven bioeconomy. Regarding BIO.NRW team invites you to actively expected to be the most dynamic ones with the fact of a continuously aging society, participate in our state’s vibrant biotech the strongest potential for growth. However, biotech solutions and products like effec- community! as their development turned out as rather tive therapies and precise diagnostics are stable, today these segments are gaining crucial to address this societal challenge. attention again for the transition into a bio- For all industry branches, innovations are based economy. They enable technological key for implementing sustainable and effi- Your BIO.NRW Team change by transferring innovations into the cient processes. North Rhine-Westphalia as traditional fields of chemistry, materials, Germany’s economically strongest federal food, and feed. Thereby, biotechnology has state offers several locational advantages the potential to significantly contribute to to support the transition into a bio-based solutions for some of the most important economy in all industry sectors. These global challenges like climate change and include a strong industry landscape of dwindling resources. And this shift is espe- start-ups, SMEs and global enterprises, an cially important for North Rhine-Westphalia excellent science and innovation landscape as the structural change of large regions of the highest density in Germany as well as in the state is taking place now. The struc- agricultural resources. NRW and especially

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Content

Editorial… ……………………………………………………………………………… 5 Company Directory 2018/2019 NRW

Greeting… ……………………………………………………………………………… 7 Non-specific Services… …………………………………………………… 28

Spot on Biotechnology Business… ………………………………… 11 Health and Medicine (including Animal Health)… …… 38

Biotech Landscape……………………………………………………………… 11 Industrial Biotechnology… ……………………………………………… 52

Stimuli for Start-Up‘s… ……………………………………………………… 11 Agrobiotechnology… ………………………………………………………… 58

Academic Biotech Research … ……………………………………… 13 Bioinformatics… ………………………………………………………………… 62

Biotech Business… …………………………………………………………… 17 Other Biotechnologically Active Companies……………… 66

Competence Clusters… …………………………………………………… 21 BIO.NRW Home of Biotech in North Rhine-Westphalia……………………………………………… 72 Industrial Biotechnology – CLIB2021 ……………………………… 21 Glossary… …………………………………………………………………………… 74 Pharmaceutical Biotechnology – BIO.NRW.red … …… 22 OECD Definition… ……………………………………………………………… 74 From Mind to Market … …………………………………………………… 23 Organisation for Economic Co-operation and Development (OECD)… …………………………………………………… 74 Biotechnology Map of North Rhine-Westphalia Life Science Technology Parks and Incubators… …… 24 Biotechnology company… ……………………………………………… 74

Dedicated biotechnology companies … ……………………… 74 Biotechnology Map of North Rhine-Westphalia Dedicated and other biotechnologically active Other biotechnologically active companies… …………… 74 companies … ……………………………………………………………………… 26 Business Areas of Activity… …………………………………………… 74

Contact BIO.NRW……………………………………………………………… 74

Sources, Literature, Links… …………………………………………… 74

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Spot on Biotechnology Business

Biotech Landscape Colognes “Koelnmesse” is the No.1 venue bust funding environment to support and for more than 25 different industries. promote the industry including venture North Rhine-Westphalia (NRW) is at the Traditionally, North Rhine-Westphalia capital providers and business develop - heart of Europe. 160 million people – al - has been Germany’s most important loca- ment organizations. most a third of the population of the Eu - tion for the pharmaceutical and chemical Biotechnology in NRW represents an ropean Union – live within a day’s drive of industry. Today the state has also devel- active, multicentric network, which is set- Düsseldorf, the state capital. 23.3 % (i.e. oped into a life sciences hotspot: a good ting the pace for the powerful pulse of the EUR 172.5 bn in 2017) of the direct foreign reason for many top-level biotechnology state’s life science business. Meanwhile investment that flows into Germany ends companies and research institutes to have biotechnology is a maturing industry that up in North Rhine-Westphalia, where some their headquarters here. Numerous suc- expands rapidly. Its innovative technolo- 14.000 international companies control cessful start-up and spin-off companies gies are applied to major industry branches their German and European operations are flourishing in NRW alongside a strong serving health/medicine, chemistry, food from. NRW also is the number one trading chemical and pharmaceutical industry and environment. North Rhine-Westphalia state among Germany’s 16 federal states. 1 that includes many well-known household has been developing its biotechnology Summing up the in- and export of NRW names like Bayer, Evonik, Henkel, Grünen- hotspot since 1995. More than 20 years into the trading volume in 2018 was EUR 438 thal, Johnson & Johnson or UCB. the program, about 500 life science related bn.2 With around EUR 705 bn in 2018, NRW This business excellence is endorsed by companies are located here1 – among them generated 20.8 % of the German GDP, a dense network of outstanding academic 119 biotechnology enterprises including putting it clearly at the top of all German institutions, which focus on biotechnology several global players (Figure 1). federal states.3 within a broad life sciences landscape. In Major business areas covered are indus- The state accounts for 4.4 % of the addition, there is an equally rich and ro - trial, nano- and pharmaceutical biotechnol- European GDP (EU-28), making it one of ogy, and there is a focus on enabling tech- the most important economic regions in nologies and supporting services as well. Europe. Comparing NRW in an international Combining the strong technical expertise ranking, it is ahead of several European evolving from these areas has been the key countries such as Switzerland, Sweden, 102 driver for NRW as the state is pioneering the dedicated 1 Poland, and Belgium. With 17.9 million biotechnology field of bioeconomy in Germany. inhabitants – of which 10 million live in the companies Rhine-Ruhr area, that lists among the top Stimuli for Start-Up‘s 20 metropolitan areas in the world – NRW 17 other is by far the most populous German state.4 biotechnologically Many of today’s successful young biotech active companies Consequently, the state boasts the high- companies started as university spin-offs. est level of infrastructure within Germany They took advantage of life science incuba- including the country’s densest railway tors and technology centers, whose exist- ~380 other life science 1 network and six international airports. related companies ence can be pivotal for a start-up company. Handling 127.5 million tons of goods in As catalysts for regional infrastructure and 2018, Duisburg is the world’s largest inland economic development, there are approxi- port.5 With over 100 annual international mately 60 such centers and incubators in trade fairs NRW has the largest trade fair Fig. 1: Life Science Company Landscape in the immediate vicinity of universities and venue of the world. North Rhine-Westphalia basic research institutions in NRW.1

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19 % of all German start-ups are based in NRW, the highest rate of all German states.6 IDEA MARKET They perform technology transfer all the way from mind to market. At the time of the edi- Branch Product/Service torial deadline of this brochure, a total of 118 biotech and life science related companies Energy Raw Materials / Fuels were incubated by 23 of these technology 7 (functionalized) Foods / Fertilizer / Crops / centers. You will find the respective locations Agriculture of the centers and the number of biotech Plant Protection companies each of them hosts on the map on Proteins / Peptides / Chemicals through Biotech Chemical Industry page 24. The services these start-up centers Processes (Enzymes, MO) / Molecular Electronics provide include renting of affordable labora- Basic / fundamental / Pre-requisite for applied Basic Research tory and office space, mediating business reserach and development contacts, consulting on funding opportuni- Drug Delivery / (Companion) Diagnostics / ties, and advising on either founding or relo- Healthcare / Pharma Medical Devices / Therapeutics cating a firm. Business plan competitions are BIOTECHNOLOGY offered as an additional chance for support. Facilities / Infrastructure Transport ⁄ Laboratory supply / Materials One technology park that deserves to find special mention here is BioCampus Cologne, Engineering Nanotechnology Engineering Laboratory Information Systems / Digital (Biomedical) - IT one of the largest of its type in Germany. It Healthcare / Biological Computing / Databases houses more than 23,000 square meters of office and laboratory space, including state of the art S1- and S2 labs, and industrial produc- Fig. 2: Biotechnology is a strongly linked industry tion facilities on a site totaling more than 25 hectares. Company founders, young entre- demic institutions. It consists of internation- ity). 27.2 % of all German students are taking preneurs and scientists all profit from NRW’s ally renowned Universities and Universities advantage of this excellent environment for highly-networked biotechnology scene. of Applied Sciences (78; 25 with life science science and education and are pursuing activity), Max Planck Institutes (14; 6 with their studies in NRW4. Remarkably, one third Academic Biotech Research life science activity), Fraunhofer Institutes of all STEM fields (Science, Technology, (15; 6 with life science activity), Helmholtz Engineering and Mathematics) students North Rhine-Westphalia is offering Germa- Institutes (4; 3 with life science activity) and are studying in NRW. University centers ny’s most comprehensive network of aca- Leibniz Institutes (9; 6 with life science activ- can be found in Aachen, Bonn, Cologne,

Percentage of NRW Annual turnover Total R&D expenditure (Mio. EUR) NRW * Germany ** relative to Germany Number of 1,000 4,930 23,540 20.9 employees 800 918 Turnover Mio 1,808 4,510 40.1 4,51 bn EUR R&D expenditure 277 1,195 23.2 600 Mio Biotechnology 102 679 15.0 400 active companies 277 * data according to survey by BIOCOM AG, ** data according to biotechnologie.de 40.1 % 59.9 % 0 (http://biotechnologie.de/statistics_articles/28-die-deutsche-biotechnologie-branche-2019) NRW Rest of Germany NRW Rest of Germany Fig. 3: Key biotechnology facts; NRW and Germany

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Düsseldorf, Münster, Bochum, Essen, Dort- Table 1: Temporal Development Key Figures for the Biotechnology Industry of mund, Bielefeld, and other cities in the state. North Rhine-Westphalia In the area of biotechnology, students have the opportunity to specialize in cell biology, 2016 2017 2018 (bio-) medicine, biochemistry, genomics, Number of 4,963 5,573 4,930 proteomics, metabolomics, molecular employees biology, systems and synthetic biology, Turnover EUR 1.819 bn EUR 2.073 bn EUR 1.808 bn analytics/microsystems, bioinformatics R&D and process engineering. EUR 394 m EUR 366 m EUR 277 m NRW is exceptional in the research fields expenditure of health and sustainability, which both are based on company survey by BIO Deutschland e.V. based on survey by BIOCOM AG future-orientated topics given the fact of an increasing and ageing world population and Another Excellence Cluster located in NRW search in Cologne deserves to be called the climate change. is Immunosensation2 in Bonn, which was es- Germany’s “cradle of plant biotechnology” For over a decade, NRW has been the tablished in 2012 with a grant of EUR 28 m. as the first plant transformation technolo- leading German region in stem cell research Scientists study the immune sensatory gies were developed here. It is also part of and development with Münster, Bonn and system, which plays a role in many modern the Cluster of Excellence on Plant Science Cologne as hotspots. diseases, such as diabetes and cancer. Both (CEPLAS), a collaboration of several uni- The example of the university campus Excellence Clusters, Immunosensation2 and versities and research institutes that was in Cologne emphasizes the very dynamic founded in 2012. In 2019, the second fund- development of NRW as a research location. 2 % 2 % ing period of CEPLAS started with a new The Cluster of Excellence-Cellular Stress grant of EUR 56.8 m for 7 years. CEPLAS ad- Responses in Aging-Associated Diseases 8.8 % dresses strategies for the improvement of (CECAD), the Max Planck Institute for Biol- crops against the background of a changing ogy of Ageing and the Center for Integrated 43.1 % environment and society. Sustainable Crop Oncology are located here. Additionally, sev- production is also a focus of the Cluster of eral world leading neuroscience institutes 44.1 % Excellence PhenoRob in Bonn. The project are located in close proximity. Along with tackles sustainable crop production via the German Center for Neurodegenerative technology-driven approaches including Diseases and the respective institutes of multi-scale monitoring of plants using the Universities of Cologne and Bonn as well autonomous robots. The subject of energy as their University Hospitals, Cologne has utilization from renewable resources is developed into a worldwide unique compe- below 10 10-49 50-99 covered by the Excellence Cluster Fuel Sci- tence center for ageing research. 100-249 more than 250 ence Center in Aachen. The Cluster works About one hour west of Cologne, Eu - on the conversion of renewable energy into rope’s most innovative technology campus Fig. 4: Size of Dedicated Biotechnology “bio-hybrid fuels”. The Bioeconomy Science is currently taking shape: after the recent Companies (Number of Employees) Center (BioSC) is a competence center by realization of the “Campus Melaten”, the the universities of Aachen, Düsseldorf and RWTH Aachen University is now going to CECAD, received new funding in 2019 for Bonn as well as the Jülich Research Center. expand further by building the “Campus another 7 years, which underlines NRW’s BioSC supports research addressing sus- West”. Covering another 800,000 square position in health research. In addition, tainable bioeconomy, which is an important meters in total, the new campuses of the North Rhine-Westphalia is the federal state issue given the fact that bioeconomy is one RWTH Aachen University will house sev- in Germany where most Excellence Clusters strategy for the structural change of the eral technology clusters, among them the were funded in 2019. Rhenish mining area. All these activities “cluster biomedical technology”, and take In the field of plant genetics, the Max reflect how NRW is keeping pace in times up investments of EUR 1 bn. Planck Institute for Plant Breeding Re - of climate change by promoting research

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16 BIO.NRW that addresses sustainability and future- finding a simple value chain or separating annually carries out a statistical analysis orientated technologies. it from other, more “static” industries, of the German core biotech companies The digital transformation is a highly is difficult. Biotechnology routinely uses allowing a more sophisticated view of the strategic topic for the life science indus- other technologies, e.g. nanotechnology or biotechnology landscape in Germany. try and could influence competitiveness engineering, to improve products. However, The framework of the analysis is set in the future. Digitalization in the area of all colors of biotechnology (green, red, by the OECD definition of a dedicated life sciences is generally seen as an op - white and blue) are linked to diverse other biotech company and biotech associated portunity, however, some companies are branches like the chemical industry (Figure companies (see page 74). Based on this slow to implement new technologies. The 2, page 13). definition, 102 dedicated biotech com - federal state of North Rhine-Westphalia Putting the view on single services and panies were operating in NRW in 2018. supports the digital transformation. The products makes it obvious, that looking Their activities were complemented by 17 NRW government is planning the foundation only on dedicated biotechnology compa- other companies with a biotechnological of a European block chain institute at the nies reveals an artificially reduced impact commitment, mostly global players in the Fraunhofer Institute for Material Flow and biotechnology has on the entire industry. field of pharmaceuti-cals, chemicals or Logistics in Dortmund. In addition, a block For example, a recent report elucidated that seed production. Since these companies chain real world laboratory (“Reallabor”) the sum of the turnover of the European are active in many diverse areas, their was set up in the “Rheinisches Revier” this bioeconomy industry is more than EUR 2.3 biotech related business figures cannot year for technical implementation trials of trillion (!) and over 18.6 million people are be calculated exactly and are not included new blockchain technologies. The project employed in bio-based industries, underly- in the following statistics. 15 % of all Ger- consortium includes the Fraunhofer Society, ing the importance of biotechnology on the man biotech companies are located in NRW the RWTH Achen, Ruhr University Bochum, overall economy.8 (Table 2, page 21). the Westphalian University of Applied Sci- Nevertheless, it is crucial to have a uni- The real economic impact of biotech - ences Gelsenkirchen and RegioIT Aachen. form definition of the core biotech com - nology in NRW is therefore higher than The project aims the cooperation of science, panies to monitor the development of the these statistics reveal. These dedicated industry and start-ups. industry. This is especially true for start- companies listed in this brochure are at Cooperations of academia and industry ups, which are the innovative center of the the innovative core of biotechnological are creating synergy effects, to give one community. For this purpose, BIOCOM AG research and development. In contrast example, the Research Center Jülich has to the business figures of the dedicated a long-standing cooperation with Siemens biotech companies – as an example – the 3.9 % 2.9 % Medical Solutions to develop specialized 2018 sales of Bayer AG and Evonik Indus- instruments and techniques for brain tries AG alone, both headquartered in 9 research. BIO.NRW offers detailed infor- 19.6 % NRW, are EUR 39.6 bn and EUR 13.3 bn mation about the academic life science 10, respectively. Even though only a part 44.1 % landscape in NRW in its compendium “Spot of their turnover can be assigned to NRW on Biotechnology Science”. This brochure sites and not all products are generated is composed in a similar manner like “Spot 29.4 % involving biotech processes, the key busi- on Biotechnology Business“ and presents a ness sectors of both companies are based total of 227 profiles of research institutes, on biotechnology. These two examples centers and facilities in NRW. Its second is- clearly demonstrate the enormous impact sue was released in November 2016. biotechnology has on the overall industry Health and med. Non-specific services in NRW and Germany. Biotech Business Bioinformatics Agrobiotechnology Germany as well as its federal state NRW Industrial biotechnology are innovative biotechnology regions. Out Biotechnology became one of the most all granted EPO patents worldwide, 16.3 % dynamic business sectors over the past few Fig. 5: Areas of activity (for definitions see went to Germany in 2018. That puts Ger- decades. Having such a complex industry, page 74) many on the third place after the USA and

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Japan.11 Regarding the federal states of Indication Number of Products Germany, NRW is among the top three states when it comes to general patent fil- Neoplasms / cancer / oncology 29 ings.12 In terms of biotechnology, four of the Infectious and parasitic diseases 18 top ten companies worldwide that handed Diseases of the nervous system 15 in patent applications in 2018 are operating Skin and subcutaneous tissue 7 in North Rhine-Westphalia.4 Musculoskeletal system and connective tissue 6 The business figures of the 119 NRW Symptoms, signs abnormal clinical and laboratory findings, not elsewhere classified 4 biotechnological active companies are Respiratory 2 set into comparison with the 679 German Digestive system 2 biotech companies.13 In NRW 4,930 people Other 2 (of about 23,540 nationwide) – more than Mental and behavioural disorders 1 in any other German federal state – were Endocrine, nutritional and metabolic diseases 1 employed by dedicated biotech companies Diseases of the blood and blood-forming organs; immune disorders 1 in 2018.4,14 They generated a turnover of approximately EUR 1.8 bn (Table 1, page Total 88 15), which corresponds to 40.1 % of the German biotech annual turnover.4,15 Fig. 6: Drug Development Pipeline by Indication Thus, the biotech industry in NRW is – to a large extend – responsible for the EUR 17 m and USD 10 m in 2018 due to big community of business angels based economic impact of the German biotech financing rounds in Jennewein Biotechnol- in NRW, numerous (institutional) investors business as a whole. 15.3 % of the NRW ogy GmbH, Evorion Biotechnologies GmbH set up their business headquarter along the annual turnover in biotechnology (EUR and Protembis GmbH. In 2019 EUR 12.3 m Rhine within the last years. These investors 277 m) was reinvested into R&D projects. 14 and USD 5.2 m were raised by CryoThera- strongly foster young biotech companies. The development of this key business peutics GmbH, INFANDX AG and Hemovent Investment activities into life science figures underlines that the investments GmbH.15 Of course, the total amount companies are also supported by the state, by the dedicated biotech companies in of non-public investments into biotech e.g. through our “BIO.NRW Business Angel NRW are persistent in essence and will companies in NRW was much higher than Zirkel” and our annually “Business Angel advance the future market position of NRW these numbers reveal. In addition to the Congress”. biotech. Together, NRW biotech firms are placing the highest investments for R&D of Discovery innovative products – nationwide. Overall, n/a 8 24 the proportional expenditure, of biotech companies based in NRW, for R&D, being at 15.3 % of the annual turnover is more than 5 times higher than the mean of all businesses in Germany (3.04 % in 2017). 16 The employee structure reflects the mix- Preclinical 36 ture of companies based in NRW: 43.1 % of On the Market all companies have less than 10 employees, 8 44.1 % have 10 - 49 employees, 8.8 % have 50 - 99 emplyoees and 4 % employ Phase III more than 100 people (Figure 4, page 15).14 1 Phase II After financing rounds of EUR 2 m in 5 Phase I 6 2017 contributed by Grünenthal Group, the investment strongly increased to Fig. 7: Drug Development Pipeline by Phase

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29.4 % of biotech companies in North Rhine- Table 2: Number of dedicated biotech companies Westphalia are active in multiple branches (Figure 5, page 17).14 These biotechnology NRW dedicated biotech Germany Business Year companies with “nonspecific business ac- companies (active companies) tivities” include service providers and sup- 2008 61 501 pliers for the industry. Among Germany’s 2009 68 531 three largest biotech companies regarding 2010 71 538 the number of employees are QIAGEN GmbH and Miltenyi Biotec B.V. & Co. KG.19 As 2011 77 552 Qiagen has developed into the field of medi- 2012 84 565 cal applications, meanwhile the company is 2013 87 570 accounted as a dedicated biotech company in the „health-medicine“sector. 2014 89 579 QIAGEN began as a spin-off from the 2015 95 590 University of Düsseldorf in 1984. Today, the 2016 109 623 company employs 5,200 experts in over 2017 108 647 35 locations worldwide and is Germany’s largest biotech company. It has become the 2018 102 679 leading provider of sample technology and 2007 - 2014 and 2018 based on survey by BIOCOM AG; 2015 - 2017 based on survey by BioDeutschland a top player in molecular diagnostics especially in cancer detection and prevention. a decrease of 13 % compared to 2018 (101 refers to companies that develop enzymes, Through a number of strategic moves QIA- drugs in pipeline). The detailed distribu - biomaterials or bioprocesses, which can be GEN today is one of the leading companies tion by indication clearly lists “neoplasms/ applied to facilitate or enable large-scale in biomarker discovery and development cancer/oncology” as top one category with production in the chemical industry. The (i.e. companion diagnostics), which is the 29 products in pipeline in 2019 (Figure 6, NRW-based companies Henkel and Evonik basis for the company’s redirection to the page 19). Although the number of prod - have been pioneering industrial biotechnol- health business. ucts slightly decreased compared to 2018 ogy worldwide and are still its pacesetters Based on the invention of a magnetic cell (34 products), the category “Neoplasms/ today. separation technology, Miltenyi Biotec was cancer/oncology has been the main focus founded 1989 in Bergisch Gladbach near of product development for several years. Competence Clusters Cologne. Since then, the company has This is followed by “infectious and parasitic expanded to more than 3.000 employees diseases” with 18 products in pipeline in Besides the large number of biotech com- worldwide who produce and market over 2019 (19 products in 2018). The category panies, which have specialized in enabling 14,000 products for the global biomedical “Diseases of the nervous system” remained technologies, two main fields of activity research community. It is remarkable that constant with 15 products in pipeline (2018 characterize the biotechnology landscape in this success has been solely achieved by and 2019) and the category “Skin and sub- North Rhine-Westphalia: Industrial Biotech- generic growth. cutaneous tissue” is on the fourth place with nology and Pharmaceutical Biotechnology. The majority of dedicated NRW biotech 7 products in pipeline in 2019 (5 in 2018).15 companies (44.1 %) are active in the field The pipeline includes 12 therapeutics Industrial Biotechnology – CLIB of health and medicine including veterinary (17 in 2018, Figure 7, page 19) in the clini- medicine (Figure 5, page 17).14 At the time cal phases I to III (13.6 %). The majority CLIB (Cluster Industrial Biotechnology) is of the editorial deadline of this brochure, of products (40.9 %) are preclinical drug an international open innovation cluster of the dedicated biotech companies in the candidates. The overall number of products large companies, SMEs, academic institutes field of health and medicine had developed in the development pipeline significantly in- and universities, as well as other stakehold- a drug pipeline of in total 88 products and creased compared to 2017 with 99 products ers active in biotechnology and bioeconomy product candidates, which corresponds to (+ 32.9 %).15 The underlying classification as a whole. The cluster comprises about

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100 members with a share of about 25 % based on lignocellulose. Within the project the number of compounds in clinical devel- international members. The overall goal of BioCOnversion, the partners will develop a opment (Phase I – III) decreased slightly in

CLIB is to network stakeholders along and biotechnological process for CO/CO2 gas 2018 (from 639 to 635) the biopharmaceu- across value chains and to identify new conversion. In CROSSBEE a cross-border tical pipeline is still filled. And beyond that opportunities for innovation, projects and bioeconomy education will be established. the absolute high numbers of candidates in business. Through this, the cluster develops All three projects are coordinated by CLIB development (635 compounds) represent cross-sectoral biotechnological solutions and are funded by the German Federal Min- a continuous and huge investment in the for sustainable processes and products. istry of Education and Research (BMBF) with biopharmaceutical development pipeline. Pertinent project areas are identified by the EUR 3 m over a period of 3 years. More than 20.0 % of the entire phase III CLIB team in conjunction with members in pipelines are biosimilars.17 an iterative process. Pharmaceutical Biotechnology – For more than a century, NRW has been CLIB is a non-profit association, with its BIO.NRW.red the heartland of Germany’s pharmaceutical members shaping the cluster’s interests and industry with an exceptional standard in activities. The cluster coordinates several as- In the last decades, major milestones biotechnological and medical education. sociated programs, which cover different as- in medicine and healthcare have been This advantage, combined with the enor- pects of bioeconomy, and invites members to achieved through pharmaceutical (“red”) mous market potential of biopharmaceuti- become involved. To this end, CLIB organizes biotechnology, namely in the development cals, gave reason for BIO.NRW’s strategic a number of events throughout the year: the of drugs, vaccines and diagnostics. In 2018, initiative in the field of red biotechnology annual CLIB international conference (CIC), 400 medical biotech companies were regis- called BIO.NRW.red. forum events, topic-specific workshops, dedi- tered in Germany, 119 of them already have Its starting point was the competition cated small partnering meetings and visits biopharmaceutical products in the market “Bio.NRW” in 2009, a call for projects an- to partners, sites or meetings in Germany and / or have their own product pipeline. nounced by NRW’s Ministry of Innovation, and abroad. The remaining 281 companies contribute Science and Research (MIWF; renamed to In NRW, CLIB is coordinating the regional to drug development for example by their MKW, Ministry of Culture and Science of the innovation network (RIN) “Stoffströme”, technology platforms. For many years most State North Rhine- Westphalia in 2017) to which seeks to improve the exploitation of of the German biotech companies have support the cooperation between academia biomass, wastes, and side streams in the re- been active in the field of red biotechnol- and biotech companies. The focal areas of gion. This action is funded by NRW’s Ministry ogy. 17 Likewise, in NRW the key task of most the successful projects were: development of Culture and Science (MKW). Another NRW- (43.7 %) of the dedicated biotech compa- of drugs (biologicals and small molecules), based project is dedicated to improve identi- nies is developing drugs or diagnostics or generation of new methods in diagnostics, fication and production of high performance finding new ways for drug delivery.14 establishment of biomarkers and introduc- ingredients (HiPerIn2.0) for markets like Taking a closer look at the overall German tion of new biopharmaceutical technology adhesives, cosmetics, or food and feed. This medical biotechnology area, including bi- platforms – especially based on cell cul- action is funded by the Ministry of Economic opharmaceuticals, again the year 2018 has tures technology. Affairs, Innovation, Digitalization and Energy been a good one. The sales of biopharma- Since then several further calls for proof the State of North Rhine-Westphalia. ceuticals in Germany increased by 11.7 % in posals in the field of red biotechnology were Besides this, CLIB established together 2018 relative to 2017 and reached a volume published by the NRW´s State Government. with partners in Germany, Flanders, and of about EUR 11.4 bn, which corresponds to The BIO.NRW.red initiative has been in - the Netherlands, the BioInnovation Growth 27.4 % of the total pharmaceutical market creasingly involved in supporting the forma- mega-Cluster (BIG-Cluster), which aims at in 2018. 38 (24 new biopharmaceutical tion of new consortia in “PerMed.NRW” (by developing novel cross-border value chains compounds, 14 biosimilars) out of 65 newly the end of 2010), focused on personalized on the topics lignocellulose, C1 gases, approved drugs were biopharmaceuticals in medicine and in “Translational Stem Cell aviation fuels and cross-border education. 2018. This corresponds to 58 % of all new Research” (finished in June 2014). Three projects under the BIG-Cluster are approvals – more than ever before.17 In line with the “Lead market strategy” currently running. In ALIGN the consortium Since 2005 the biopharmaceutical pipe- of the state of North Rhine-Westphal - aims at producing new high-value aromatics line has much more than doubled. Although ia, a new series of competitions (Leit -

22 BIO.NRW

Institute for Ecology and Innovation, com- marktwettbewerbe NRW) was launched Agri/Agrobiotechnology missioned by Bio based Industries Consorti- in 2015, focusing on translational re - Bioinformatics um search in eight so-called lead markets. Other biotechnologically companies [9] https://www.bayer.de/de/2019-02-27-bi- By the end of the LifeSciences.NRW lanz-pressekonferenz.aspx competition in December 2018, 173 con- For a more comprehensive directory that in- [10] https://corporate.evonik.de/de/unterneh- sortia had participated in the 4 rounds. cludes all life science and life science related men/zahlen-fakten/ From this, 41 projects will be funded with a companies in NRW, please visit our company [11] European Patent Office, Statistics: https:// 18 www.epo.org/about-us/annual-reports- total of EUR 73.8 m. Members of the new database at https://www.bio.nrw.de/db/. statistics/statistics.html consortia will further expand the sustain- BIO.NRW invites you to discover North [12] Neuhäusler P, Rothengatter O, Frietsch R: able network BIO.NRW.red, which brings Rhine-Westphalia‘s biotechnology com- Patent Applications – Structures, Trends together key supporters from the medical, munity! and Recent Development 2017, Studien zum healthcare, pharmaceutical industry and deutschen Innovationssystem Nr. 4-2018, red biotechnology sectors in the state. Sources, Literature, Links Fraunhofer Institute for Systems and Inno- vation Research ISI; https://www.e-fi.de/ fileadmin/Innovationsstudien_2018/Stu- [1] https://www.nrwinvest.com From Mind to Market DIS_04_2018.pdf [2] https://www.it.nrw/statistik/eckdaten/aus- [13] http://biotechnologie.de/statistics_ und-einfuhr-2008-2018-2095 articles/28-die-deutsche-biotechnologie- This chapter provides an overview of 102 of [3] https://www.statistik-bw.de/VGRdL/tbls/ branche-2019 the dedicated and 17 of the other biotechno- tab.jsp?rev=RV2014&tbl=tab01&lang=de- [14] Analysis by BIOCOM AG logical-active companies from North Rhine- DE#tab04 [15] http://www.biotechgate.com/web/cms/ Westphalia as classified following the OECD [4] https://de.statista.com/ index.php/start.html guidelines (page 74). For convenience, the [5] https://www.duisport.de/hafeninformati- [16] https://data.oecd.org/rd/gross-domestic- on/ companies are grouped in six areas accord- spending-on-r-d.htm [6] KPMG Deutscher Startup Monitor 2019; ing to their main business: [17] Biotech-Report “Medizinische Biotechno- https://deutscherstartupmonitor.de/fi- logie in Deutschland 2019” von vfa bio und leadmin/dsm/dsm-18/files/Deutscher%20 BCG; www.vfa-bio.de Non-specific Services Startup%20Monitor%202018.pdf [18] LeitmarktAgentur.NRW; www.leitmarkt- Health and Medicine [7] Analysis by BIO.NRW agentur.nrw/leitmarktwettbewerbe/lifesci- (including Animal Health) [8] Pitrowski S, Carus M, Carrez D: European ences Industrial Biotechnology Bioeconomy in Figures 2008 – 2016, nova-

23 BIO.NRW

Biotechnology Map of North Rhine-Westphalia Life Science Technology Parks and Incubators

The Netherlands

Q Gronau Weser

Q Bielefeld 4 1 8 Q Münster Q Ascheberg Q Rheda-Wiedenbrueck 1 Ems Rhine

Lippe

Q Bönen Dortmund 9 Essen 7 1 1 Q BochumQ Q Q 1 17 Essen 2 Q Ruhr Q Nettetal Witten 1 Q Witten Q Wuppertal Düsseldorf Q 12 Q Hilden Q Monheim 7 Q Langenfeld 1 Q Bergisch-Gladbach 3 6 10 Baesweiler 1 Q Köln Q Jülich 4 Herzogenrath 4 Q Q Troisdorf Q Rhine 4Q 7 Aachen Q Bonn3 Rheinbach Q Belgium Germany

24 BIO.NRW

Name City Companies* Homepage

ZBMT - Zentrum für Bio-Medizintechnik 7 1 Aachen www.agit.de TZA -Technologiezentrum am Europaplatz Aachen 4

2 INCA Technologiezentrum GmbH Ascheberg 1 www.inca-technologiezentrum.de

3 its-Internationales Technologie- und Service-Center Baesweiler Baesweiler 3 www.its-center.de Bergisch- 4 Technologiepark Bergisch-Gladbach 1 www.tbg.de Gladbach 5 Technologiezentrum Bielefeld Bielefeld 1 www.technologiezentrum-bielefeld.de

6 BMZ - BioMedizinZentrum Bochum Bochum 7 www.bmz-bochum.de

7 TZR - Technologiezentrum Ruhr Bochum 1 www.chip-tzr.de

8 Bio-Security Bönen 9 www.bio-security.de

9 BMZ - BioMedizinZentrum Dortmund Dortmund 17 www.bmz-do.de

10 Zentrum für Mikro- und Nanotechnologie Dortmund 1 www.mst-factory.de

11 LSC - Life Science Center Düsseldorf Düsseldorf 12 www.lsc-dus.de

12 ETEC - Essener Technologie- und Entwicklungs-Centrum GmbH Essen 1 www.etec.de

13 TPH - Technologie Park Herzogenrath Herzogenrath 4 www.tph.de

14 TZJ - Technologiezentrum Jülich Jülich 1 www.tz-juelich.de

15 BioCampus Cologne Grundbesitz GmbH & Co. KG Köln 6 www.biocampuscologne.de

16 RTZ - Rechtsrheinisches Technologie- und Gründerzentrum Köln Köln 10 www.rtz.de

17 TechnologiePark Köln Köln 4 www.tpk.de

18 Creative Campus Monheim Monheim 7 www.cc-monheim.de www.technologiefoerderung- 19 Technologieförderung Münster GmbH Münster 8 muenster.de 20 CeNTech - Center for Nanotechnology Münster 4 www.centech.de

21 Gründer- und Technologiezentrum Rheinbach Rheinbach 3 www.wfeg-rheinbach.de

22 Forschungs- und Entwicklungs-Zentrum Witten GmbH Witten 2 www.fez.de

23 Technologiezentrum Wuppertal W-tec GmbH Wuppertal 1 www.w-tec.de

Total: 23 118

* Life Science Companies

25 BIO.NRW

Biotechnology Map of North Rhine-Westphalia Dedicated and other biotechnologically active companies

The Netherlands Q Gronau Weser Q Bad Salzuflen Q Münster Bielefeld Q Q Leopoldshöhe

Q Ascheberg Ems Q Rhine Bocholt

Lippe Q Marl Q Lippstadt Q Moers Q Q Dortmund Duisburg Q Q Bochum Essen Q Witten Ruhr Q Q Wuppertal Nettetal Düsseldorf Q Q Erkrath Neuss Q MonheimQ Hilden Mönchengladbach Q Q Q Langenfeld Q Leverkusen Q Bergisch Gladbach Baesweiler Q Q Köln Q Q Jülich Herzogenrath Q Troisdorf Q Würselen Q Q Düren St. Augustin Q Aachen Rhine Q Bonn

Belgium Germany

26 BIO.NRW

Dedicated companies1, 3 Morphoplant GmbH Bochum p. 46 Acus Laboratories GmbH Köln p. 29 multiBIND biotec GmbH Köln p. 55 Adhesys Medical GmbH Aachen p. 39 Myriad International GmbH Köln p. 47 AgroJector UG Köln p. 59 NEO New Oncology GmbH Köln AgroProtect GmbH Aachen p. 63 Neracare GmbH Köln AiCuris Anti-infective Cures GmbH Wuppertal p. 39 NEUWAY Pharma GmbH Bonn p. 47 Algiax Pharmaceuticals GmbH Erkrath p. 39 Noscendo GmbH Duisburg p. 63 Alvotech Germany GmbH Aachen NUMAFERM GmbH Düsseldorf p. 35 arrows biomedical Deutschland GmbH Münster p. 40 PAIA Biotech GmbH Köln p. 35 ARTES Biotechnology GmbH Langenfeld p. 29 PAION AG Aachen p. 47 attyloid GmbH Düsseldorf p. 40 Pharmedartis GmbH Aachen p. 48 Autodisplay Biotech GmbH Düsseldorf p. 57 phytolinc GbR Köln p. 55 AYOXXA Biosystems GmbH Köln p. 29 Phytowelt GreenTechnologies GmbH Nettetal p. 60 BBT Biotech GmbH Baesweiler p. 30 PL BioScience GmbH Aachen p. 35 beniag GmbH Jülich p. 30 PlasmidFactory GmbH & Co. KG Bielefeld p. 36 Bex-Biotech GmbH & Ko.KG Münster p. 59 Priavoid GmbH Jülich p. 48 BIBITEC Gesellschaft für Prozessentwicklung mbH Bielefeld p. 30 Protagen AG Dortmund p. 48 BioCheck GmbH Münster p. 40 Protagen Protein Services Dortmund p. 36 BioEcho Life Sciences GmbH Köln p. 41 QIAGEN Hilden p. 49 Biofidus AG Bielefeld p. 31 QITHERA GmbH Düsseldorf p. 49 Biofrontera AG Leverkusen p. 41 RHEINCELL Therapeutics GmbH Langenfeld p. 49 BioSolveIT GmbH Sankt Augustin p. 63 Ridom GmbH Münster p. 64 bitop AG Witten p. 53 Saaten-Union BIOTEC GmbH Leopoldshöhe p. 60 Black Drop Biodrucker GmbH Aachen p. 31 SanguiBioTech GmbH Witten BluCon Biotech GmbH Köln SenseUp GmbH Jülich BSV Bioscience GmbH Baesweiler p. 53 Senzyme GmbH Troisdorf p. 56 Carpegen GmbH Münster p. 41 SeSaM-Biotech GmbH Aachen p. 56 CellAct Pharma GmbH Dortmund p. 42 Soluventis GmbH Bochum p. 50 Squarix GmbH Marl p. 36 CellSystems Biotechnologie Vertrieb GmbH Troisdorf p. 31 Succinity GmbH Düsseldorf Cevec Pharmaceuticals GmbH Köln p. 42 Syntab Therapeutics GmbH Würselen p. 50 Charles River Laboratories Germany GmbH Erkrath p. 32 Taconic Biosciences GmbH Köln Chembiotech Münster Transimmune AG Düsseldorf p. 50 Chimera Biotec GmbH Dortmund p. 32 UGiSense AG Dortmund p. 51 Cilian AG Münster p. 42 UriCell GmbH Düsseldorf p. 51 CIRES cell & immune research services Bochum p. 43 vivo Science GmbH Gronau p. 37 Creative-Therapeutics GmbH Wuppertal p. 43 W42 Industrial Biotechnology GmbH Dortmund p. 56 Cube Biotech GmbH Monheim p. 32 WeissBioTech GmbH Ascheberg Cygenia GmbH Aachen p. 43 XanTec bioanalytics GmbH Düsseldorf p. 37 Cysal GmbH Münster p. 54 Cytocentrics Bioscience GmbH Köln Xell AG Bielefeld p. 37 Dr. Seibt Genomics GmbH Bonn Other biotechnologically active companies2, 3 Dynavax GmbH Düsseldorf Baxter Oncology GmbH Halle/Westfalen EVORION Biotechnologies GmbH Münster p. 33 Bayer AG Leverkusen p. 67 Evotec SE *formerly Ncardia Cologne Köln p. 44 BASF Personal Care and Nutrition GmbH Monheim evoxx technologies GmbH Monheim am Rhein p. 54 BAYER CropScience AG Monheim GEN-IAL GmbH Troisdorf p. 33 Bayer Pharma AG Wuppertal IFM Therapeutics GmbH Bonn Deutsche Saatveredelung AG Lippstadt p. 67 IIT - Institut für Innovationstransfer Bielefeld p. 63 Evonik Industries AG Essen p. 67 IMAX Discovery GmbH Dortmund p. 54 Evonik Industries GmbH Marl IMD Natural Solutions GmbH *acquired by Lanxess Dortmund Evonik Nutrition & Care GmbH Halle/Westfalen ImmunoQure AG Düsseldorf p. 44 German Seed Alliance GmbH Köln p. 68 InfanDx AG Köln p. 44 Grünenthal GmbH Aachen p. 68 innoVitro GmbH Jülich Henkel AG & Co. KGaA Düsseldorf p. 68 Isoloid GmbH Düsseldorf p. 33 MEDIWISS Analytik GmbH Moers Lead Discovery Center GmbH Dortmund p. 45 Monsanto Agrar Deutschland GmbH Düsseldorf LenioBio GmbH Düsseldorf p. 34 *acquired by Bayer AG Life & Brain GmbH Bonn p. 45 Octapharma GmbH Langenfeld Lonza Cologne GmbH Köln p. 34 PerkinElmer chemagen Technologie GmbH Baesweiler p. 69 m2p-labs GmbH Baesweiler p. 55 PHARMA WALDHOF GmbH Düsseldorf p. 69 Matricel GmbH Herzogenrath p. 45 Syngenta Seeds GmbH Bad Salzuflen p. 69 MBBL Dr. Bartling GmbH Bielefeld Taros Chemicals GmbH & Co. KG Dortmund miacom diagnostics GmbH Düsseldorf p. 46 UCB GmbH Monheim p. 70 Miltenyi Biotec B.V. & Co. KG Bergisch Gladbach p. 34 W. von Borries-Eckendorf GmbH & Co. KG Leopoldshöhe p. 70 MLM Medical Labs GmbH Mönchengladbach p. 46 1 List of dedicated biotechnology companies in the fiscal year 2018 1 2 OECD Definition page 74 3 including company sites in NRW that are not headquarters and are therefore not accounted as NRW-based companies in the annual study by “BIO Deutschland e.V.” 27 Non-specific Services

28 BIO.NRW non-specific services

prediction to pharmaceutical industry and Name Acus Laboratories GmbH biotech partners. Acus mid-term vision is to uncover novel drug target structures that initiate Address Joseph-Stelzmann-Straße collaborative ‘first-in-class’ drug develop- 9b ment projects. Postal Code/City 50931 Köln Acus Laboratories GmbH was founded in 2018 as a spin-off company from the Max Fon +49-22137970-920 Planck Institute for Biology of Ageing in E-Mail [email protected] Cologne. Based on unique forward genetic Internet www.acuslabs.com screening technologies Acus offers services for deconvolution and validation of Employees <10 molecular drug target structures, identifi- Founded (year) 2018 cation of off-targets, and drug resistance

mendation, international registration, EMA Name ARTES resp. FDA approval and GRAS certification Biotechnology GmbH are achieved in international collaborations. Expression platforms include high yield Address Elisabeth-Selbert-Str. 9 yeasts and E. coli system for efficient pro- Postal Code/City 40764 Langenfeld ARTES Biotechnology is an independent tein production. Our unique chimeric virus technology provider for the pharmaceuti- like particle (VLP) platform METAVAX® is Fon +49 2173 27587-0 cal industry. Our business focus is on: best suited for the development of highly Fax +49 2173 27587-77 • vaccine development (VLP technology) immunogenic vaccines in human and ani- E-Mail [email protected] • process development of biopharma- mal health. Internet www.artes- ceuticals Our proprietary technologies ensure biotechnology.com • transfer of biosimilar processes freedom-to-operate and reliable, competi- Employees 22 Our technologies have resulted in innovative tive production of innovative targets mar- Founded (year) 2002 products marketed worldwide. WHO recom- keted worldwide.

support of basic biology and across drug Name AYOXXA Biosystems GmbH development. With its advantages in terms of quality, flexibility, robustness and efficiency, LUNARIS™ enables fully scal- Address Nattermannallee 1 able research & validation of biomarkers Postal Code/City 50829 Köln in minute amounts of biological samples. AYOXXA Biosystems GmbH is an inter- AYOXXA is commercializing a growing Fon +49 221 222529-0 national life science company based in portfolio of standardized ready-to-use Fax +49 221 222529-11 Cologne. With LUNARIS™, its proprietary biomarker analysis assays, with a focus on E-Mail [email protected] innovative beads-on-a-chip multiplexing the biology of inflammation and immune Internet www.ayoxxa.com platform for advanced protein analysis, response. the Company is paving the way for trans- Employees 35 lating knowledge generated in a laboratory Founded (year) 2010 environment through clinical studies in

29 non-specific services BIO.NRW

rators, filtration systems, chromatography Name BBT Biotech GmbH and freeze dryers. On the basis of individual needs BBT Biotech GmbH also offers active Address Arnold-Sommerfeld-Ring 28 pharmaceutical ingredients like thrombo- Postal Code/City 52499 Baesweiler lytics (streptokinase, urokinase), fertility hormones (HCG, HMG, FSH), inhibitors Fon +49 2401 93310-0 BBT Biotech GmbH produces freeze-dried (Aprotinin, UTI) and others (Hyaluronidase, Fax +49 2401 93310-90 viable bacteria (probiotics like lactobacilli, Corticotrophin). E-Mail [email protected] bifidobacteria, yeasts) and metabolites not Internet www.bbt-biotech.de only in bulk but also in finished dosage forms to the pharmaceutical and health- Employees 30 food industry. Founded (year) 1999 The fermenter capacity is up to 18.000 l. The downstream process is based on sepa-

aggregate with extremely high efficiency Name beniag GmbH within a few minutes. The unique transfer Address Huthmacherstrasse 20 mechanism allows manipulation of basi- Postal Code/City 52428 Jülich cally every mammalian cell type and incor- porates molecules directly into the cytosol, Fon +49 2461 616734 to guarantee their immediate bioactivity. +49 15780393499 beniag is a biotechnology company pro- beniag focusses on production and de- Fax +49 2461 613907 viding unique and highly efficient solutions velopment of customer oriented solutions E-Mail [email protected] to incorporate molecules into living cells with cooperation partners distributing the Internet www.beniag.com and tissue in vitro. Based on membrane product line “Fuse-It” worldwide. fusion as a completely novel and patented Employees < 10 transfer mechanism, beniag liposomes of- Founded (year) 2013 fer an outstanding opportunity for customers to incorporate any type of molecule or

and market production. Our value added Name BIBITEC GmbH services also include pharmaceutical development, ICH conform stability and viral safety studies. Address Universitätsstr. 25 BIBITEC Gesellschaft für Prozessent- Our project manager is your primary Postal Code/City 33615 Bielefeld wicklung mbH, a 100 % subsidiary of contact and is responsible for steering Nordmark Arzneimittel GmbH, is offering the entire process. With our customized Fon +49 521 106-6326 an all-in-one solution for mammalian cell project support BIBITEC is the partner of Fax +49 521 106-156233 culture technology. choice for biotech companies with indi- Internet www.bibitec.de Together with qualified partners, BIBITEC vidual needs. is able to cover the entire value chain from Employees 12 cell line and process development, analy- Founded (year) 2001 tics, GMP production of API and finished drug product up to regulatory affairs

30 BIO.NRW non-specific services

or biosimilars, including but not limited to Name Biofidus AG monoclonal antibodies, Fc-fusion proteins, erythropoietin, and ADCs. Additionally, Biofidus offers spent media analysis for Address Hainteichstrasse 78 fermentation and cell culture technology, Postal Code/City 33613 Bielefeld which includes the analysis of amino acids, Biofidus is an analytical company located metabolites, and vitamins in culture media. Fon +49 521 999 89 400 in Bielefeld, Germany. Its services include The analytical service also includes the Fax +49 521 999 89 409 a wide variety of bioanalytical methods development of custom tailored and novel E-Mail [email protected] such as spectroscopic, chromatographic, client-specific assays. Internet www.biofidus.de and mass spectrometric assays focused on characterization of proteins as well as Employees 10 small molecules. Biofidus is specialized in Founded (year) 2015 the characterization of biopharmaceuticals

analogues, such as skin, liver, or heart Name Black Drop Biodrucker muscle patches offer an ideal platform for GmbH drug and toxicity screening. In the future bioprinted tissue implants could be used to maintain, restore, or substitute the Address Gasborn 41 function of damaged tissues. As experts Postal Code/City 52062 Aachen in 3D-bioprinting we provide our clients with outstanding bioprinting hard- and Fon +49 173 2618 104 Black Drop Biodrucker GmbH is a lead- software, highly biofunctional bioinks, and E-Mail [email protected] ing bioprinting company focused on bioprinted in-vitro models. Internet www.thebioprinting.com 3D-printing of living cells. Bioprinting is Besides our compact 3D-bioprinter a biomedical key technology that has the series, Black Drop SuperFill, we construct Employees 3 potential to improve medical patient treat- individualized bioprinting systems and Founded (year) 2017 ment in multiple ways. Bioprinted tissue develop tailored organ models.

In 2010, we opened our new clean room Name CellSystems GmbH laboratories to meet the growing demands for various 3D tissue models and services. Today, our portfolio comprises a wide range of products for cell biology research Address Langeler Ring 5 Since its formation CellSystems ® has and in vitro toxicology studies. Postal Code/City 53842 Troisdorf been a reliable partner for the life science CellSystems is certified ISO 9001:2015. community. CellSystems offers highly so- Fon +49 2241 25515-0 phisticated research products, including Fax +49 2241 25515-30 EU validated 3D in vitro skin models for E-Mail [email protected] research and toxicology assays that were Internet www.cellsystems.de developed and are produced at our onsite laboratories. Additionally, CellSystems Founded (year) 1992 offers a wide range of contract services.

31 non-specific services BIO.NRW

programs, we support clients throughout Name Charles River Laboratories Germany GmbH the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical Address Max-Planck-Str. 15A studies to marketed products. Postal Code/City 40699 Erkrath With more than 50 years of experience and Whether clients need stand-alone ser- proven regulatory expertise, the Charles vices, a unique package of testing, or Fon +49 211 9255-300 River Biologics group can address chal- insourced support, our Biologics group Fax +49 211 9255-333 lenging projects for biotechnology and can create a custom solution to suit their E-Mail [email protected] pharmaceutical companies worldwide. needs. Internet www.criver.com Offering a variety of services such as contamination and impurity testing, pro- Founded (year) 1993 tein characterization, bioassays, viral clear- ance studies and stability and lot release

Corporate mission: Chimera Biotec is Name Chimera Biotec GmbH service provider for the development, validation and support of ultra sensitive and Address Emil-Figge-Str. 76a technically demanding immunoassays Postal Code/City 44227 Dortmund for quantifying large molecule targets in virtually any biological matrix. Chimera Fon +49 231 9742-840 Description: Chimera Biotec is a GLP/GCP Biotec provides ultra sensitive GLP/GCP Fax +49 231 9742-844 certified bioanalytical Contract Research bioanalytical support for all phases of E-Mail [email protected] Organization (CRO) specialized in ultra drug discovery and development. Chimera Internet www.chimera-biotec.com sensitive large-molecule bioanalysis on Biotec has the expertise and technical various technology platforms including capabilities to identify the ideal platform Employees 20 proprietary immuno-pcr (Imperacer ®) technology based on and run according Founded (year) 2000 technology. to your pharmacological and regulatory requirements.

manufactured in house at high quality. The Name Cube Biotech GmbH product offering is complemented by reagents such as detergents, cell-free expres- Address Alfred-Nobel-Str. 10 sion lysates, nanodisc scaffold proteins, Postal Code/City 40789 Monheim The Cube Biotech team serves the biotech and patented membrane protein crystal- and pharmaceutical community with its lization plates. Some particularly relevant Fon +49 2173 99373-0 expertise on expression, purification, membrane proteins (GPCRs) are available Fax +49 2173 99373-99 stabilization and functional/structural as fully characterized preparations. E-Mail [email protected] characterization of proteins. Our projects Our services cover the expression, pu- Internet www.cube-biotech.com focus on the pharmaceutically relevant rification, stabilization and crystallization class of membrane proteins. Both products of soluble and membrane proteins for ap- Employees 16 and services are offered: A broad range of plications like cryo electron microscopy, Founded (year) 2012 products for the affinity chromatography antibody generation, crystallization and of proteins and stabilization of proteins are assays.

32 BIO.NRW non-specific services

and to investigate individual cells for multi- Name EVORION® Biotechnologies ® parametric analysis. The approach is highly GmbH parallelized, e.g. providing simultaneous and fast analysis of thousands of cell interactions at a time. This novel approach Address Mendelstrasse 17 EVORION® Biotechnologies GmbH spe- will accelerate cell biology research, clinical Postal Code/City 48149 Münster cialized in developing innovative high- product development and the development performance live-cell analysis systems of novel and effective cell therapies target- Fon +49 251 287 693-39 to decipher highly complex biological ing cancers and many other diseases. E-Mail [email protected] mechanisms like cellular communication Internet www.evorion.de at single cell resolution. The unique microfluidic chip-based Employees 13 technology allows the user to manipulate Founded (year) 2017 single living cells in biological matrices,

cally modified organism (GMO), allergenes, Name GEN-IAL GmbH plant and animal-identity. The laboratory is accredited (DIN EN ISO/IEC 17025) and official cross checking laboratory. We are Address Heuserweg 13-15 member in the German official working Postal Code/City 53842 Troisdorf GEN-IAL GmbH is a specialist laboratory group for method development for GMO for DNA based food and feed analyses. detection and quantification. We are an Fon +49 2241 252-2980 GEN-IAL offers services and kits for GMO-, approved laboratory for the German VLOG Fax +49 2241 252-2989 allergene- and animal identity analyses as (Verband Lebensmittel ohne Gentechnik E-Mail [email protected] well as bacteria- and yeast detection and e.V.) for GMO-free labeling. Internet www.gen-ial.de differentiation. We offer training in PCR, New: Capturing of microorganism by contract research, several kits for DNA- polymer technology. Employees 10 extraction, PCR-kits for beer/wine spoilage Founded (year) 1998 bacteria and yeast, pathogenes, geneti-

due to harmful effects on the producing Name Isoloid GmbH organisms. Based on an innovative and proprietary technology Isoloid GmbH overcame this challenge to offer high purity protein sam- Address Erkrather Str. 401 ples and labeled derivatives to your lab. Postal Code/City 40231 Düsseldorf As a joint spin-off from Heinrich-Heine- High-purity samples of amyloid proteins University Düsseldorf and Forschungszen- Fon +49 211-81 15143 and peptides are a key prerequisite for trum Jülich we build on a strong expertise E-Mail [email protected] research and development on many severe and plenty years of experience in structural Internet www.isoloid.de diseases, such as Alzheimer’s, Parkinson’s biology and biophysics to promote your and Diabetes mellitus type 2. However, research project. Employees <10 the biotechnological production of these Founded (year) 2015 proteins turned out to be challenging

33 non-specific services BIO.NRW

etary protein production platform, ALiCE®, Name LenioBio GmbH which enables protein drugs to be brought to market faster and at lower cost. ALiCE® Address c/o Factory Campus, is exclusively licensed from DowDuPont Postal Code/City Erkratherstr 401 and the Fraunhofer Institute. 40231 Düsseldorf At LenioBio GmbH, everything we do ALiCE® will target to pharma & biotech begins with our Mission: to provide our sector to make development and manufac- Fon +49 211 890940300 customers with innovative solutions that ture of protein drugs faster and more ef- E-Mail [email protected] address their toughest challenges – eas- ficiently than existing production systems. Internet www.leniobio.com ily, quickly and more efficiently. This deep ALiCE® offers a fully integrated protein commitment is at the core of our name: Le- production platform with unique capabili- Employees 24 nio, from the Latin “to ease, make better”. ties and the ability to scale with customers’ Founded (year) 2016 LenioBio is a biotech company that needs. develops and markets a novel and propri-

GmbH offers customized services, e.g. Name Lonza Cologne GmbH transfection services, proliferating cell services and cell modification services.

Address Nattermannallee 1 The Lonza Cologne site develops, manu- Postal Code/City 50829 Köln factures and markets a comprehensive product portfolio of life-science research Fon +49 221 99199-190 tools around cultured cells, including non- E-Mail [email protected] viral gene transfer products for primary Internet bioscience.lonza.com cells and hard-to-transfect cell lines. These products support scientists Employees 109 worldwide, enabling more efficient identi- Founded (year) 1998 fication of new targets for pharmaceuticals and therapies. Additionally Lonza Cologne

Over 30,000 scientific publications and Name Miltenyi Biotec B.V. & Co. KG the manufacture of more than 50,000 cell products for clinical use demonstrate the Address Friedrich-Ebert-Str. 68 profound trust scientists and clinicians Postal Code/City 51429 Bergisch Gladbach have in MACS® Technology. Miltenyi Biotec has been at the forefront Fon +49 2204 8306-0 Miltenyi Biotec develops products and ser- of immunology, stem cell biology, cancer Fax +49 2204 85197 vices that advance biomedical research and research, and neuroscience, as well as the E-Mail [email protected] cell therapy. Our technologies inspire scien- clinical areas of hematology, graft engi- Internet www.miltenyibiotec.com tists in basic and translational research, and neering, and apheresis, for nearly 30 years. support clinical applications. Our integrated About 3,000 employees in 28 countries are Employees 3,000 solutions enable sample preparation, cell passionate about our cell and gene therapy Founded (year) 1989 separation, cell sorting, flow cytometry, cell solutions. culture, and molecular analysis.

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Our mission is to make peptides cheaper Name NUMAFERM GmbH and their production more eco-friendly in comparison to predominant chemical synthesis. With lower prices and a scalable process, they also become accessible for Address Merowingerplatz 1a non-pharmaceutical applications. Postal Code/City 40225 Düsseldorf NUMAFERM has developed an efficient and Founded in 2017, NUMAFERM is a venture effective biotechnology for the production capital-backed startup company headquar- Fon +49 211 9753290-0 of recombinant peptides. The drawbacks of tered in Düsseldorf, Germany. E-Mail [email protected] available bioprocesses are overcome – for Internet www.numaferm.com example proteolytic damage, aggregation and toxicity issues. Our technology serves Employees 12 as a reliable platform for peptides of any Founded (year) 2017 length.

cence detection. The assays are amenable Name PAIA Biotech GmbH to automation and run on fluorescence plate readers or microscopes. PAIA Biotech focuses on products for screening applications with limited sample volume and high Address Gottfried Hagen Str. 60-62 throughput requirements, e.g. in early cell Postal Code/City 51105 Köln line development. PAIA Biotech GmbH offers assays for the In addition to off-the-shelf products PAIA Fon +49 221 1686 2380 rapid quantification of antibodies and pro- Biotech GmbH also offers custom assay E-Mail [email protected] teins as well as glycosylation assays based development. Internet www.paiabio.com on its proprietary technology. This technol- PAIA Biotech GmbH was founded in 2014 ogy uses proprietary 384-well microplates and is based at the RTZ in Cologne. Employees 10 that drastically simplify the workflow of Founded (year) 2014 bead-based immunoassay with fluores-

ucts, the team accelerates the translation of Name PL BioScience GmbH basic research into cell therapy. The start-up has a broad expertise con- BioScience cerning human Platelet Lysate as an alterna- WE DELIVER CELL SOLUTIONS tive to the ethical and safety-related doubt- Address Dennewartstraße 25-27 ful Fetal Bovine Serum. PL BioScience offers Postal Code/City 52068 Aachen diverse human Platelet Lysate-derived PL BioScience is an ambitious and dynamic products, e.g. the patent-protected 3D cell Fon +49 241 95719-100 life science start-up committed to cell ex- culture system PLMatrix. With its pathogen- Fax +49 241 95719-109 pansion in safe conditions. The company reduced products, the company provides E-Mail [email protected] has developed a portfolio of novel products a ‚new generation’ human Platelet Lysate Internet www.pl-bioscience.com and innovative technologies for human cell complying the highest safety guidelines for expansion in research and clinical applica- cell expansion in clinical and therapeutic Founded (year) 2015 tions. With its animal component-free prod- environments.

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Germany. The company offers the pro - Name PlasmidFactory GmbH & Co. KG duction of plasmid and minicircle DNA in several quality grades: Research Grade and Address Meisenstr. 96 ccc Grade for research purposes and pre- Postal Code/City 33607 Bielefeld clinical applications, High Quality Grade as starting material for e.g. GMP production Fon +49 521 2997-350 of RNA and viral vectors and GMP Grade Fax +49 521 2997-355 PlasmidFactory is the leading contract for clinical applications. E-Mail [email protected] manufacturer of plasmid and minicircle Besides production of individual plas- Internet www.plasmidfactory.com DNA and the driving force in the develop- mids and minicircles, In Stock products ment of non-viral vectors for gene therapy that are deliverable immediately “off-the- Employees 23 and genetic vaccination. PlasmidFactory’s shelf”, e.g. reporter genes and AAV Helper Founded (year) 2000 research and development as well as the & Packaging vectors (pDG/ pDP family, complete service are located in Bielefeld, several serotypes) are also provided.

characterization incl. modification of new Name Protagen Protein Services GmbH biological entities as well as biosimilar products. Comprehensive proteome studies and Address Otto-Hahn-Straße 15 differential protein display techniques are Postal Code/City 44227 Dortmund offered in addition for example to support Fon +49 231 9742-6100 Protagen Protein Services (PPS) is a world up and downstream process optimization of Fax +49 231 9742-6149 leading contract research organization with biotherapeutic production. PPS combines E-Mail contact@ProtagenProtein an large international customer base in the unique expertise in e.g. bioinformatics for Services.com field of Protein Analytics of biotherapeutics. protein mass spectrometry with a long track Internet www.ProtagenProtein With more than 20 years of market experi- record in protein chemistry and protein Services.com ence, PPS is able to offer a comprehensive, analytics. PPS provides you with the full Employees 70 GMP compliant spectrum of state of the range of services, from drug discovery and Founded (year) 1997 art analytical methods, ensure the highest development to release testing and regula- quality for the identification and structural tory compliance under ICH Q6B.

compounds for drug discovery industry and Name Squarix GmbH biotechnology reagents for life science applications com- prising antibodies, metabolic intermediates, Address Elbestr. 10 fluorescent dyes & probes and different af- Postal Code/City 45768 Marl finity matrices for proteins and cells. Moreover, Squarix is a custom producer Fon +49 2365 915-278 of polyclonal and monoclonal antibodies Fax +49 2365 915-254 Squarix GmbH is a privately-held primary for biomedical research and offers all type E-Mail [email protected] manufacturer of high purity Discovery of immunoanalytical services in the field of Internet www.squarix.de Chemicals and Immunoreagents. Since antibody technology. 1992, Squarix produces a broad product Employees 8 line of compounds that include innovative Founded (year) 1992 building blocks, reactive intermediates, natural products and derivatives, screening

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from biotechnology. By merging with the in- Name vivo Science GmbH ternational Texcell Group with subsidiaries in Europe, Asia and North America, vivo Science has expanded its portfolio and now acts as Address Fabrikstr. 3 a full service provider in the preclinical test- Postal Code/City 48599 Gronau ing of biologics, pharmaceuticals, medical devices and chemicals as well as in GMP cell Fon +49 2562 8170-0 banking and viral safety. Fax +49 2562 8170-19 vivo Science is a GLP/GMP certified service In addition, vivo Science can include im- E-Mail [email protected] company for the pharmaceutical industry munological tests into standard toxicity Internet www.vivoscience.de (CRO) offering in vivo toxicology studies and studies. vivo Science will provide GLP/GMP is specialized in the testing of immunotoxi- compliant, validated study protocols and Employees 17 city (ICH-S8) and immunogenicity (ICH-S6) will assist you in setting up a customized Founded (year) 2001 of new drug candidates, especially if derived test program for your special requirements.

devices. The hydrogel nanolayers exhibit Name XanTec an excellent haemo- and tissue compat- bioanalytics GmbH ibility and can be derivatized with growth or adhesion factors. Address Merowingerplatz 1a As complement to the biochip product Postal Code/City 40225 Düsseldorf line, XanTec offers SPR biosensors, which Nanobiotech company having more than allow highly sensitive real-time and label- Fon +49 211 9936-4744 20 years experience in surface deriva - free detection of biomolecular interactions Fax +49 211 9936-4746 tisation with bioinert and biofunctional at the molecular level. These instruments E-Mail [email protected] nanocoatings. Manufactures SPR or other can analyze binding constants / kinetics Internet www.xantec.com biosensor chips, coated slides for protein, and allow rapid concentration determina- cell and DNA based assays. Custom coat- tion, drug screening, epitope mapping, or Employees 12 ing of many materials, including glasses, adhesion studies with cells or viruses. Founded (year) 1997 metals and plastic, also for biomedical

etc). Our chemically defined products are Name Xell AG animal-component free and compliant for GMP manufacturing. Apart from the media Address Waldweg 21 platform we offer fast and reliable analytical Postal Code/City 33758 Schloss Holte- services - among others, proprietary meth- Stukenbrock ods for amino acid, vitamin or polyamine analyses. Additionally, cell culture and Fon +49 5207 9597-200 Xell is an innovative partner for the biotech process services are provided to better Fax +49 5207 9597-201 and pharmaceutical industry, providing ef- understand cellular behavior and optimize E-Mail [email protected] ficient solutions in cell culture technology. cultivation processes. We are happy to an- Internet www.xell.ag Based on its proprietary technology, Xell has nounce our new ISO 9001 certified produc- developed a range of customized as well as tion site for large scale production of liquid Employees 35 commercial culture media and feeds for the and powder media, ready by end of 2019. Founded (year) 2009 most commonly used cell types (CHO, HEK,

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Health and Medicine (including Animal Health)

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seal areas of leakage or re-attach tissue, or Name Adhesys Medical GmbH as a hemostat, to stop bleeding. The company was founded in 2013 in Aachen, Germany. In February 2014, the founders closed a 7-digit seed investment Adhesys Medical GmbH develops fully syn- round with S-UBG, KfW and a group of Address Pauwelsstraße 17 thetic, biodegradable surgical adhesives. private investors. In April 2014 the team Postal Code/City 52074 Aachen The first product FLIX® is designed for der- won the Rice Business Plan Competition in mal use, to close a great variety of topical Houston, Texas and expanded to the United Fon +49 241 41250320 wounds, and has received its CE-mark in States. In April 2017 the company was Internet www.adhesys-medical.com January 2018. Based on its unique poly- acquired by the pharmaceutical company urethane platform technology Adhesys Grünenthal and operates now as a wholly- Employees 25 develops further products for use inside owned subsidiary with offices in Aachen, Founded (year) 2013 the human body: either as an adhesive, to Germany and Boston, United States.

megalovirus (CMV), was licensed to MSD Name AiCuris Anti-infective and achieved market approval in the all Cures GmbH major markets for the prophylaxis of CMV infections in recipients of bone marrow Address Friedrich-Ebert-Str. 475 transplants. Postal Code/City 42117 Wuppertal Further projects include Pritelivir, a AiCuris is focused on discovery, research helicase-primase inhibitor, developed Fon +49 202 31763-0 and development of novel, resistance- to treat recurrent herpes simplex and Fax +49 202 31763-1177 breaking antiviral and antibacterial agents AIC649, a novel biological immunomodu- E-Mail [email protected] for the treatment of severe and potentially lator targeting Hepatitis B cure, as well as Internet www.aicuris.com lifethreatening infectious diseases. Since preclinical programs in Bacteriology and November 2017, the first product from Virology. AiCuris’ projects focus on new Employees 65 AiCuris is on the market. Letermovir, a modes of action and/or represent novel Founded (year) 2006 terminase-inhibitor of the human cyto- chemical classes.

been finalized in >100 subjects and showed a Name Algiax Pharmaceuticals good safety and tolerability profile in healthy GmbH volunteers. A phase II clinical study will start in late 2019 to show proof-of-concept in Address Max-Planck-Str. 15a patients suffering from neuropathic pain. Postal Code/City 40699 Erkrath Algiax Pharmaceuticals is a clinical-stage Next to AP-325 Algiax has discovered nov- biotechnology company established in 2011. el GABAA receptor modulator compounds Fon +49 211 617851-15 It is dedicated to the discovery and develop- called Thioacrylamide (ThAc) derivatives. Fax +49 211 617851-50 ment of innovative products to treat diseases The company is advancing a selection of E-Mail [email protected] with a high unmet medical need. Algiax’ ThAcs derivatives from its discovery to Internet www.algiax.com lead candidate AP-325 is a small-molecule preclinical characterization GABAA receptor modulator in clinical devel- Employees 6 opment as a therapy for neuropathic pain. Founded (year) 2011 The comprehensive Phase I program has

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microarrays(GenExpression, Array-CGH, Name arrows biomedical Deutschland GmbH ChIP on chip, DNA-Methylation-Microar- rays), PCR (RT-qPCR, Dpca) and bioinfor- Address Heisenbergstraße 11 matics. In the area of medical diagnostics, Postal Code/City 48149 Münster the portfolio includes routine analysis (testing for all clinical relevant biomarkers Fon +49 251 534064-00 arrows biomedical Deutschland carries and the complete range of blood analysis), Fax +49 251 534064-01 out contract research and clinical routine flow cytometry (NAVIOS), HPLC analysis, E-Mail [email protected] analyses, and also pursues its own R&D diagnostic microarrays, detection of freely Internet www.arrows-biomedical.com projects. The firm’s areas of focus are pri- circulating tumor cells, and chemosensitive marily in the fields of molecular oncology analysis. Furthermore, FISH analysis, general Employees 10 and neurodegenerative disease. Its port- microscopy with the Zeiss axio imager M 2 in Founded (year) 2005 folio of molecular analytics includes RNA/ combination with the MetaSystemsSoftware DNA. Services like RNA/DNA isolation, and Pyro-, NGS and Sanger sequencing.

nological production chain. Name attyloid GmbH attyloid offers its proprietary sFIDA platform technology featuring single particle Address Elsa-Brändström-Str. 34 sensitivity and a 4-log dynamic range of Postal Code/City 40595 Düsseldorf particle size and concentration. The ISO attyloid GmbH was founded in 2018 and is 9001-embedded sFIDA technology is fully located in Düsseldorf, Germany. Building automized and scalable. Fon +49 211 81 10377 on a strong scientific expertise in protein E-Mail [email protected] misfolding and aggregation, we focus our Internet www.attyloid.com business model on aggregate quantitation for development and QC of biologicals. Employees <10 Our mission is to revolutionize aggre- Founded (year) 2018 gate analytics to safeguard the biotech-

Biocheck GmbH offers a broad range of Name BioCheck GmbH different Polycheck® test panels which can be performed manually or fully automated matching with central Laboratory Address Vorbergweg 41 Information Systems (LIS). Evaluation and Postal Code/City 48159 Münster The Polycheck® Platform Technology calculation is done by picture scanning and was introduced by Biocheck GmbH as a by Biocheck Imaging Software. Fon +49 251 2150-868 tool for medical in vitro diagnosis of al - E-Mail [email protected] lergies and autoimmune diseases. The Internet www.polycheck.de solid phase immunoassay technology is a multiparameter test device for serological Employees 25 quantitative screening of disorder-specific Founded (year) 1999 immunoglobulins using monoclonal detection antibodies.

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a revolutionary single-step technology for Name BioEcho Life Sciences accelerated and simplified DNA and RNA GmbH purification processes. We apply this technology in the development of more convenient Liquid Biopsy Address Nattermannallee 1 procedures (isolation of circulating nucleic Postal Code/City 50829 Köln acids), faster NGS workflows, Point-of-Care diagnostics applications, and selected cus- Fon +49 0221 9988 97-0 Founded 2016 by a team of experts in tomization projects. E-Mail [email protected] genomic sample preparation (extraction Internet www.bioecho.de & clean-up of nucleic acids) BioEcho Life Sciences provides a new generation of kits Employees < 10 and reagents for genomic research and mo- Founded (year) 2016 lecular diagnostics. BioEcho has developed

prescription-only medication to treat non- Name Biofrontera AG melanoma skin cancer and its precursors with photodynamic therapy. Ameluz ® is Address Hemmelrather Weg 201 marketed in the EU and in the United States. Postal Code/City 51377 Leverkusen Additionally, the company markets Xepi, a Biofrontera AG is a biopharmaceutical com- prescription drug for the treatment of im- Fon +49 214 87632-0 pany specializing in the development and petigo in the US. In the EU, Biofrontera also Fax +49 214 87632-90 sale of dermatological drugs and medical sells the dermocosmetics series Belixos®, E-Mail [email protected] cosmetics. which offers specialized care for damaged Internet www.biofrontera.com The Germany-based company, with al- or diseased skin. www.biofrontera.us.com most 200 employees worldwide, develops Biofrontera AG is listed on the Frankfurt and markets innovative products for the Stock Exchange (Prime Standard) and Employees 189 care, protection and treatment of the skin. since February 2018 on the US NASDAQ. Founded (year) 1997 Biofrontera’s lead product Ameluz®, is a

based system that sets new standards in Name Carpegen GmbH microbiological periodontal diagnostics. A main objective of Carpegen’s research program is to develop and out-license Address Mendelstr. 11 POC/PCR systems for diverse applica Postal Code/City 48149 Münster tions in human and veterinary medicine, Carpegen is a provider of high quality mo as well as in food/beverage and envi - Fon +49 251 980-2320 lecular diagnostics. The company focuses ronmental analytics. A joint R&D project Fax +49 251 980-2321 on developing real-time PCR assays and related to the development of innovative E-Mail [email protected] point-of-care (POC) diagnostics for the analytics of water pathogens is currently Internet www.carpegen.de diagnosis of specific infections and the being pursued with financial support of detection of genetic biomarkers. Car the German Federal Ministry for Economic Employees 10 pegen has developed Carpegen ® Perio Affairs and Energy. Founded (year) 2001 Diagnostics, a powerful real-time PCR

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CAP7.1 was acquired by MundiPharma for Name CellAct Pharma GmbH over >$250 million after a randomized, multi-center, phase II proof-of-concept Address Otto-Hahn-Str. 15 study in adults with end-stage biliary tract Postal Code/City 44227 Dortmund cancer in 2017.

Fon +49 231 9742-6350 Fax +49 231 9742-6355 CellAct’s small molecule compound, E-Mail [email protected] named CAP7.1, targets Topoisomerase II Internet www.cellact.eu and has shown efficacy and tolerability in various advanced cancer disease in phase Employees 7 I and II clinical studies. Founded (year) 2007 CAP7.1 received orphan drug status for biliary tract cancers from the EMA.

A1AT and others, with high titers and excel- Name CEVEC Pharmaceuticals GmbH lent pharmacokinetics mediated by tailor- made glycosylation. Address Gottfried-Hagen-Str. 60-62 With CAP-GT, CEVEC has developed a Postal Code/City 51105 Köln scalable platform for gene therapy vector CEVEC is a biotechnology company special- manufacturing based on suspension cell Fon +49 221 46020-800 ized in cell line and process development lines. For AAV (Adeno-Associated Viral) Fax +49 221 46020-801 for the scalable production of high-end vectors CEVEC offers a unique fully scal- E-Mail [email protected] biologics, including gene therapy vectors able, stable helper virus-free production Internet www.cevec.com and complex glycosylated recombinant system. proteins, from R&D to production scale. With CAP-Go, CEVEC enables the effi- Founded (year) 2003 cient production of complex recombinant proteins, like FVIII, C1-Inhibitor, laminins,

Name Cilian AG

Address Johann-Krane-Weg 42 Postal Code/City 48149 Münster

Fon +49 251 6203-114 Fax +49 251 6203-116 E-Mail [email protected] Cilian AG is a biotechnology company de- Internet www.cilian.de veloping and marketing a novel expression system. The company uses a species of Employees 14 Ciliates, a eukaryotic single-cell organism, Founded (year) 2001 for the production of vaccines, monoclonal antibodies and therapeutic enzymes.

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CIRES has further great experience in the Name CIRES cell + immune preclinical and clinical development and research services GmbH testing of vaccines and adjuvants. Address BioMedizinZentrum Bochum Universitätsstrasse 136 CIRES is experienced in all kinds of cell Postal Code/City 44799 Bochum culture techniques, ranging from genera- Fon +49 234 93696536 tion of hybridomas, culture of mammalian Fax +49 234 93696538 cells in general and the culture of lines of E-Mail [email protected] transgenic cells. This includes production Internet www.cires.de by Bioreactor technology, purification and labeling of monoclonal antibodies and Employees 3 development of ELISA tests. Founded (year) 2001

Currently there are no approved targeted Name Creative Therapeutics therapies of this type with such a multifac- GmbH eted mode of action. Recognizing the science-based chance Address Am Rohm 86 CreativeTherapeutics GmbH (CT) is a to realize the vision for a much more selec- Postal Code/City 42113 Wuppertal privately-held biotechnology company tive and well tolerated anticancer principle Fon +49 178 7272118 designing innovative, tailored cancer thera- CT was founded and started to realize its Fax +49 7690 7902 peutics causing genomic and metabolic mission. E-Mail zeiler@creative- instability resulting in epigenetic changes therapeutics.com leading to activation of the immunesystem. Internet www.creative-therapeutics. CT offers collaboration to advance its com lead asset CT913 through IND enabling Employees 2 studies to pave the way for Phase I in can- Founded (year) 2009 cer patients.

mesenchymal stromal cells. In addition, Name Cygenia GmbH we provide biomarkers to determine the state of aging in blood samples of mice and men. We are experts in project design and Address Am Alten Kalkwerk 14 advice you to find the best suitable bio- Postal Code/City 52078 Aachen Cygenia is the first company to provide marker for your project. We address par- service on epigenetic biomarkers. Epige- ticularly scientists and clinicians. Fon +49 241 53108060 netics is a new area of research that holds Fax +49 241 53108069 great potential for cellular analysis. E-Mail [email protected] We have established biomarkers to Internet www.cygenia.com characterize cell culture with regard to replicative senescence, pluripotency, Founded (year) 2014 cellular composition, or classification of

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provided in form of fee-for-service work, in- Name Evotec SE – Cologne site tegrated drug discovery alliances, development partnerships, licensing of innovative Address Nattermannallee 1, drug candidates and consulting arrange- Building S20 ments. Evotec operates worldwide and is Postal Code/City 50829 Köln headquartered in Hamburg, Germany. Evotec’s Cologne site leverages induced Fon +49 221 998818-0 Evotec is a drug discovery alliance and de- pluripotent stem cell (iPSC) technology for E-Mail [email protected] velopment partnership company focused neural and cardiac drug development. This Internet www.evotec.com on rapidly progressing innovative product includes bulk production of differentiated approaches with leading pharmaceutical cells, assay development and customised Employees >2.800 and biotechnology companies, academ- services in the context of safety / toxicol- Founded (year) 1993 ics, patient advocacy groups and venture ogy studies, in vitro disease modelling and capitalists. Drug discovery solutions are drug discovery screening.

been optimized by the human immune sys- Name ImmunoQure AG tem for functionality and are outstanding modulators of key proteins involved in e.g., inflammation and autoimmune disorders. ImmunoQure has established a strategic ImmunoQure AG is a young biotech com- partnership with Servier Laboratoires, Address Königsallee 90 pany focusing on the research and develop- Paris France for the development and Postal Code/City 40212 Düsseldorf ment of human-derived autoantibodies for commercialization of autoantibodies tar- the treatment of common human diseases. geting Interferon-alpha for the treatment E-Mail [email protected] Through our unique access to ultra-rare of certain human diseases. Internet www.immunoqure.com APECED/APS-1 patient populations, we are able to identify patients harboring Founded (year) 2011 autoantibodies against naturally occur- ring self-proteins. The autoantibodies have

bursed therapy underpins the high medical Name InfanDx AG need, but treatment needs to be started Address Nattermannallee 1 within 6 h after delivery. InfanDx conducted Geb. S20 2 clinical studies and ultimately intends to Postal Code/City 50829 Köln launch a blood based point-of-care test to Develops first diagnostic test to detect be applied immediately after birth. Fon +49 221 3008 9783 perinatal asphyxia (PA, oxygen deficit dur- Technology origin is metabolomics Fax +49 221 2851975 ing birth) and related braininjury. research. Product-pipeline holds further E-Mail [email protected] PA is very prevalent in childbirth world- patent backed applications. Internet www.infandx.com wide with 0.5-4 % of births affected, but InfanDx seeks partnerships as. 5-10% of newborns being at risk while initially – pharma-partnering, („companion Employees < 10 being largely asymptomatic. Typical out- diagnostic“, therapy monitoring) Founded (year) 2010 come brain damage results in e.g. cerebral – manufacturer of point-of-care device palsy/spasticism,etc. Available and reim- – marketing co-operations

44 BIO.NRW health and medicine

collaboration with world-class academic Name Lead Discovery Center researchers from LDC’s broad network in- GmbH cluding the Max Planck Society, Helmholtz Association and numerous universities. The Address Otto-Hahn-Str. 15 LDC team consists of experts with solid Postal Code/City 44227 Dortmund industry experience in Project Manage - Bridging the gap between academic dis- ment as well as Screening, Cellular Biology, Fon +49 231 9742-7000 coveries and pharmaceutical development. Pharmacology, Medicinal Chemistry and Fax +49 231 9742-7039 Active in the field of drug discovery, LDC Therapeutic Antibody Engineering. E-Mail [email protected] transforms promising early stage projects LDC has formed alliances with AstraZen- Internet www.lead-discovery.de into marketable assets providing industry eca, Bayer, Boehringer Ingelheim, Daiichi with high-quality leads and biologics with Sankyo, Grünenthal, Johnson & Johnson, Employees 75 proof-of-concept in animals. These drug Merck, Qurient, Roche and SOTIO among Founded (year) 2008 discovery projects are conducted in close others.

The four business divisions Cellomics, Name Life & Brain GmbH Genomics, Electrophysiology Services and NeuroEconomics provide human Address Venusberg-Campus 1 stem cell-based cell culture systems and Gebäude 76 services for neurological disease model- Postal Code/City 53127 Bonn LIFE&BRAIN is a biomedical enterprise ling and compound development, genome serving as commercial hub of the Uni - and gene expression analysis, electro - Fon +49 228 6885-100 versity of Bonn Medical Center. Integrat- physiology services to characterize small Fax +49 228 6885-101 ing a unique set of expertise, we aim at molecules in target engagement, efficacy E-Mail [email protected] delivering future-oriented services and and potency in human and rodent models Internet www.lifeandbrain.com products for disease-related research and and neuroscientific methods for testing the development of novel therapies with a marketing effects. Employees 35 focus on neurological and neuropsychiat- Founded (year) 2002 ric diseases.

engineering and regenerative medicine. Name Matricel GmbH The products serve different medical fields like ACI-Maix and Cartimaix for tissue engineering of articular cartilage and other orthopedic applications and Remaix Address Kaiserstr. 100 Matricel GmbH develops and produces as a dental membrane for guided bone Postal Code/City 52134 Herzogenrath innovative medical class III collagen im- regeneration. plants and biomatrices for applications in Matricel´s product Optimaix is dedicated Fon +49 2407 5644-0 medicine and biotechnology. for research in 3D cell culture. Matricel has E-Mail [email protected] Matricel´s proprietary technologies are a promising product pipeline in further Internet www.matricel.com the key to successfully produce biocom- medical fields like dermal and nerve regen- patible and biodegradable matrices in a eration with customized scaffolds. Employees 40 wide range of modifications suitable for Founded (year) 2001 the cultivation with human cells in tissue

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less than 30 minutes directly from patient Name miacom diagnostics GmbH samples without need of tedious sample Address Merowingerplatz 1a preparation or DNA amplification. Postal Code/City 40225 Düsseldorf In addition to the world´s only molecular Miacom Diagnostics is specialized in de- diagnostic (MDx) test that identifies all rel- Fon +49 211 3015-5795 veloping next-level in vitro diagnostic tests evant pneumonia-related bacteria directly Fax +49 211 2989-143 for the identification of pathogens causing from sputum, miacom offers CE & FDA E-Mail info@miacom- acute systemic diseases. Miacom improves cleared multiplex test for sepsis. Our latest diagnostics.com critical patient care by providing rapid mo- innovation includes a fully automated rapid Internet www.miacom- lecular diagnostic tools designed for routine ID system that allows high-throughput MDx diagnostics.com use to promote more efficient antibiotic testing of several hundred samples per day. Employees 10 therapies and help healthcare organizations Since 2014 Fosun Diagnostics, the diagnos- Founded (year) 2006 reduce costs. Our proprietary Direct Multi- tic division of Shanghai Fosun Pharmaceuti- plex Imaging (DMI) assays deliver results in cal, is investor by miacom.

metabolites and molecular diagnostic Name MLM Medical Labs GmbH parameters. The MLM lab is on duty 365 days a year to Address Dohrweg 63 ensure valid results with a quick turnaround Postal Code/City 41066 Mönchengladbach time. With their strategic partners Cenetron MLM Medical Labs is a GLP-certified, CLIA-, Central Laboratories in Austin, USA and Fon +49 2161 4642102 CAP- and ISO15189 accredited cen - Teddy Clinical Research Laboratory offers Fax +49 2161 4642190 tral laboratory dedicated exclusively to wordwide central lab services, especially E-Mail [email protected] clinical trials. for Europe, USA and China. Internet www.mlm-labs.com MLM offers full laboratory services, in- The extensive lab portfolio is comple- cluding a whole range of analytics: standard mented by a superior IT infrastructure (e.g. Employees 80 safety profiles, such as blood counts, co- mlm online®, MLM Sample Storage Sys- Founded (year) 1993 agulation, urinalysis, clinical chemistry, and tem®) and the MLM Kit Building® services analyses of biomarkers, drug compounds, for customized sampling kits.

production, protein chemistry, molecular Name Morphoplant GmbH and cell biology, isotope protein labeling/ monitoring and optical biosensor technol- Address Universitätsstr. 136 ogy are available to our experienced and Postal Code/City 44799 Bochum multidisciplinary R&D team. Morphoplant’s proprietary technologies provide our cus- Fon +49 234 7772870 tomers with ultrahydrophilic and osteophilic Fax +49 234 7772870-20 long-term storable metal implant surfaces E-Mail [email protected] Morphoplant GmbH is a bio-/ medtec and solutions for biocoating of a variety of Internet www.morphoplant.de company headquartered at the BioMedizin- implant materials with recombinant growth Zentrum in Bochum and focused on the inte- factors (bone/ vascular). Our outstanding Employees 14 gration of biotech functionalities into medical expertise in surface functionalization, protein Founded (year) 2002 devices. Laboratories equipped with state-of- adsorption, kinetics monitoring and animal the-art technology for recombinant protein testing is also available for contract research.

46 BIO.NRW health and medicine

therapy selection for oncological diseases Name Myriad International GmbH through precise diagnostics. Our team is highly committed to the Address Nattermannallee 1 development of diagnostic tests, using Geb. S19 advanced technologies, to provide patients Postal Code/City 50829 Köln with personalized medicine and support. Fon +49 221 669561-00 Fax +49 221 669561-99 Myriad International GmbH in Cologne E-Mail [email protected] is part of the Myriad Genetics group of Internet www.myriadgenetics.eu companies, a global leader in molecular www.endopredict.eu diagnostics. We develop and distribute Employees 25 molecular pathological in-vitro diagnostic Founded (year) 2010 tests with the aim of improving individual

ogy to encapsulate active drug substances Name NEUWAY Pharma GmbH that do not cross the blood brain barrier to successfully treat severe orphan brain diseases with a very high medical need. Address Ludwig-Erhard-Allee 2 Besides these in-house projects, NEUWAY Postal Code/City 53175 Bonn Pharma also intends to partner its CNS Drug Delivery Technology for application to Fon +49 228 522798-0 proprietary compounds of pharmaceutical Fax +49 228 522798-99 NEUWAY Pharma GmbH, Bonn, Germany, companies to exploit its therapeutic use E-Mail [email protected] is focusing on the preclinical and clinical in the field of gene therapy and rare CNS Internet www.neuway-pharma.com development of innovative therapeutics for indications. The company is backed with treatment of severe orphan brain diseases venture capital from renowned investors Employees 21 based on its proprietary CNS Drug Delivery and a strong board. Founded (year) 2014 Platform. The company uses this technol-

anesthetic drug candidate for which PAION Name Paion AG has completed the clinical development for use in procedural sedation in the U.S. with filings for market approval in China (PS), Address Martinstr. 10-12 Japan (GA) and the U.S (PS). Postal Code/City 52062 Aachen In Europe, PAION is seeking approval for PAION AG is a publicly listed specialty remimazolam in the indications general an- Fon +49 241 4453-152 pharmaceutical company developing and esthesia and procedural sedation. PAION’s Fax +49 241 4453-523 aiming to commercialize innovative drugs vision is to become an acknowledged E-Mail [email protected] for out-patient and hospital-based seda- “PAIONeer” in sedation and anesthesia. Internet www.paion.com tion, anesthesia and critical care services. PAION is headquartered in Aachen (Ger- PAION’s lead compound is remimazolam, many) with an additional site in Cambridge Employees 44 an intravenous, ultra-short-acting and (United Kingdom). Founded (year) 2000 controllable benzodiazepine sedative/

47 health and medicine BIO.NRW

RNases or kinases. Since the binder can be Name Pharmedartis GmbH almost anything making it truly scalable. Human payloads should have much less Address Forckenbeckstr. 6 side-effects. We look for partner interested Postal Code/City 52074 Aachen in out-licensing opportunities for these first-in-class products. We develop CFPs to Fon +49 241 6085132-60 treat cancer, inflammation, auto-immune Fax +49 241 6085132-66 and skin diseases. 6 products are in preclini- E-Mail [email protected] Pharmedartis (PMA) develops next genera- cal testing. CFPs for clinical testing can be Internet www.pharmedartis.de tion targeted therapies. This platform tech- produced in Aachen in proprietary system at nology of Human Cytolytic Fusion Proteins a state-of-the-art GMP facility of Fraunhofer Employees 5 (HCFP) has several advantages over well- Society, of which PMA is a spin-off. As a one- Founded (year) 2007 received ADCs. A binder is recombinantly stop-shop we provide full service from gene fused to a payload. This can be proteases, to biopharmaceutical product.

a novel mechanism of action. Aβ peptides Name Priavoid GmbH play a crucial role in AD. A β monomers can assemble to form toxic oligomers that replicate in a prion-like manner. PRI-002 Address Theodor-Heuss-Straße 179 Priavoid is developing disease-modifying is the first drug substance that acts as Postal Code/City 52428 Jülich therapies for patients with severe neurologi- an anti-prionic in animals and is safe in cal disorders like Alzheimer’s dementia (AD). humans. Fon +49 178 6157 925 The proprietary development candi - The new mechanistic principle of direct E-Mail [email protected] dates are based exclusively on D-enantio- dissolution of toxic oligomers can be ap- Internet www.priavoid.com meric amino acids (D-peptides) and there- plied to other neurodegenerative diseas- fore suitable for oral drug administration es. Priavoid advances several programs Employees 7 as capsules or tablets. at different stages of pharmaceutical Founded (year) 2017 Priavoid’s most advanced compound development. PRI-002 for the treatment of AD acts via

novel biomarkers using its proprietary Name Protagen AG immuno-profiling platform (SeroTag®), and stratification arrays based on biomarker panels (NavigAID) to screen patient serum Address Otto-Hahn-Str. 15 We specialize in Pharma development specimens. Postal Code/City 44227 Dortmund services and novel companion diagnos- We enable: Better disease activity as- tics, in the field of immuno-oncology and sessment, Improved response prediction, Fon +49 231 9742-6301 autoimmune disease. Via co-development Patient monitoring and Early detection of E-Mail [email protected] projects with Pharma and Biotech compa- immune-related adverse events (irAEs). Internet www.protagen.com nies, Protagen enables effective, targeted To find out how Protagen can support immuno-therapeutic development for your therapeutic development project to Employees 17 improved patient care. enable better response prediction, patient Founded (year) 1997 Protagen is at the forefront of im - monitoring and early detection of adverse muno-profiling and the discovery of events contact us now.

48 BIO.NRW health and medicine

say technologies make these biomolecules Name QIAGEN GmbH visible and ready for analysis. Bioinformat- ics software and knowledge bases interpret data to report relevant, actionable insights. Address Qiagen Str. 1 Automation solutions tie these together Postal Code/City 40724 Hilden in seamless and cost-effective workflows. QIAGEN provides solutions to more than Fon +49 2103 29-0 QIAGEN is the leading global provider of 500,000 customers around the world in Fax +49 2103 29-22000 Sample to Insight solutions that enable Molecular Diagnostics (human healthcare) E-Mail [email protected] customers to gain valuable molecular in- and Life Sciences (academia, pharma R&D Internet www.qiagen.com sights from samples containing the build- and industrial applications, primarily foren- ing blocks of life. Our sample technologies sics). Further information can be found at Employees ~ 5,200 worldwide isolate and process DNA, RNA, and proteins http://www.qiagen.com. Founded (year) 1984 from blood, tissue and other materials. As-

survival of cancer patients. Qithera‘s R&D Name Qithera GmbH is based on new molecular findings from RWTH research and is implemented in close collaboration with the Hospital of RWTH Aachen University. By addressing internally validated target Qithera, Düsseldorf, Germany, is a “Busi- molecules that are known to abrogate ag- Address Auf der Pief 41a ness Angel Boost” that was founded by gressive characteristics of cancer (stem) Postal Code/City 52134 Herzogenrath Prof. Edgar Dahl (RWTH Aachen University) cells, Qithera is currently characterizing together with experienced biotech experts pharmacologically active compounds that E-Mail [email protected] of the BIO.NRW network. suppress tumor spreading. The first indica- Internet www.qithera.com The company is developing innovative tion of choice is a clinical important subset drugs to suppress tumor progression of bladder cancer whose disease manage- Founded (year) 2012 and metastasis with the goal to improve ment has been stagnant for decades.

set up a resource which prevents immune Name RheinCell Therapeutics rejections in a large number of recipient GmbH patients. Thus, this master cell bank serves as “off the shelf”- platform for various types Address Berghausener Str. 98 of cell therapeutics and has the potential Postal Code/City 40764 Langenfeld to become the starting material of any RheinCell Therapeutics GmbH specializes future iPSC-based cell therapy in Europe Fon +49 2173 3282080 in the GMP-compliant generation of hu- and beyond. Fax +49 2173 3282015 man, induced pluripotent stem cells (iPSC) Additionally RheinCell is advancing its E-Mail [email protected] from allogeneic umbilical cord blood (CB). own therapeutic approach by developing Internet www.rheincell.de The main focus is on setting up an iPSC retinal pigment epithelial cells for the treat- master cell bank from HLA homozygous ment of age-related macular degeneration Employees 11 CB units. The key idea behind is that only a in cooperation with a leading research Founded (year) 2017 limited number of iPSC lines are needed to institute (USA).

49 health and medicine BIO.NRW

tive substance is loaded into the liver and Name Soluventis Nanotherapeutics GmbH into tumors in comparable concentrations. The targeting of metastases is excellent. Address Universitätsstrasse 136 The frozen ready-to-use Nanocarrier has Postal Code/City 44799 Bochum a long shelf life in ampoules whereas in The Soluventis-platform is a powerful drug the organism it is completely eliminated Fax +49 234 32 29125 delivery system, an entirely new type of within two days. Fon +49 234 32 14191 Nanocarrier characterized by high efficacy Soluventis has a portfolio of oncologic E-Mail soeren.schreiber@ and a good safety profile. siRNAs and has experience with different soluventis.de The Soluventis Nanocarrier shields drug candidates of customers. This novel Internet www.soluventis.com transported siRNA or other oligonucleo- drug delivery system opens the door to tides from blood and immune system and therapeutic oligonucleotides and we are Founded (year) 2018 reaches reliably target organs including facing the first clinical studies. poorly vascularized tumor tissue. The ac-

The company strives for the early out- Name Syntab Therapeutics GmbH licensing of product candidates. Syntab’s platform technology enables the chemi- Address St.-Jobser-Straße 56 cal synthesis of highly effective drugs for Postal Code/City 52146 Würselen immuno-oncology. The flexibility of the technology is based on the application of Fon +49 2405 40 999 50 Syntab Therapeutics is committed to the highly specific binders against cell surface E-Mail info@syntab-therapeutics. exploration und development of innovative proteins. Furthermore, the technology has com drugs against severe diseases such as the potential to vary the number and spe- Internet www.syntab-therapeutics. cancer. Syntab’s Immune System Engag- cific properties of binders and effectors com ers (ISErs) exhibit all desirable properties within the ISEr molecules. The effector of conventional antibodies while, at the part activates the patients‘ immune sys- Founded (year) 2010 same time, being significantly smaller, tem with strong efficacy. chemically accessible molecules.

munological treatment used for many years, Name Transimmune AG mainly in cutaneous T cell lymphoma (CTCL), graft versus host disease (GVHD) and organ transplant rejection. Transimmune has creat- Address Königsallee 90 TRANSIMMUNE ed two core technologies; Transimmunization Postal Code/City 40212 Düsseldorf Transimmune AG is developing novel immu- and Transtolerization. These involve protocols notherapies based on its unique understand- for manipulating the immune system that Fon +49 211 6413 6110 ing of the physiologic processes underlying have been reduced to practice through our Fax +49 211 8693 1614 the activation of antigen presenting cells. This mouse-to-man development platform, gener- E-Mail [email protected] understanding derives from nearly 30 years ating compelling preclinical proof-of-concept Internet www.transimmune.com of research into the mechanism of action data. These technologies have the potential to behind Extracorporeal Photopheresis (ECP), significantly enhance current ECP practice as Founded (year) 2012 arguably the first FDA-approved cellular im- well as drive its application more broadly into munotherapy. ECP is a highly successful im- numerous other indications.

50 BIO.NRW health and medicine

structure also allows for a rational design Name UGISense AG with regard to modifications, e.g. amphi- philic- and customizable PK-properties in addition to homing tags/peptides. Through these capacities, Ugimers™ can address the Address Otto-Hahn-Straße 15 UGISense AG is a mostly virtual biotech specific requirements of envisaged targets. Postal Code/City 44227 Dortmund company developing Ugimers™, a new type UGISense has established projects in of antisense drugs. the fields of oncology, metabolic diseases, Fon +49 231 97427063 Ugimers™ solve the challenging problems muscular dystrophies and peripheral neu- E-Mail [email protected] that antisense products have faced: deliv- ropathies. Internet www.ugisense.com ery, stability and toxicity. In comparison to competitor molecules, Their basic structure is a fully artificial Ugimers™ have shown up to 10fold efficacy Employees 2 peptidic backbone that provides Ugimers™ in tissue. IP protection is strong and durable. Founded (year) 2016 with stable properties. In addition, this

epithelial cells and induced pluripotent stem Name UriCell cells. These products are suitable for drug development, nephrotoxicity tests, research on nephrogenesis and diagnostics. The standard procedure to obtain human Address Moorenstraße 5 kidney cells - kidney biopsy - is associated Postal Code/City 40225 Düsseldorf with limitations such as availability, costs, UriCell is a spin-off from the Institute for risks and ethical issues, which UriCell avoids. Fon +49 211 81 08260 Stem Cell Research and Regenerative Medi- We are able to satisfy the increasing Fax +49 211 81 17858 cine (University Hospital Düsseldorf). demand for high quality human kidney E-Mail [email protected] UriCell uses urine as an innovative non- cells, resulting from the rising prevalence Internet www.uricell.de invasive biomaterial to generate human of kidney-associated diseases, need of personalised kidney stem cell products, alternatives for animal testing and growing Founded (year) 2020 including renal progenitor cells, tubular complexity of drug development processes.

51 BIO.NRW

Industrial Biotechnology

52 BIO.NRW industrial biotechnology

numerous benefits to biocatalysis, the func- Name Autodisplay Biotech GmbH tionalisation of solid surfaces and screening applications. With its custom-tailored products and services, Autodisplay Biotech is an ideal Address Merowinger Platz 1a partner for leading companies in the chemi- Postal Code/City 40225 Düsseldorf cal, pharmaceutical and biotechnology industries. Fon +49 211 2095 1378 Autodisplay Biotech GmbH is a biotechnol- E-Mail [email protected] ogy company commercializing its propri- Internet www.autodisplay-biotech.com etary expression platform for the display of heterologous proteins or peptides on Employees 6 the surface of gram negative bacteria. This Founded (year) 2008 cell surface display technology provides

tremolytes, these fascinating living beings Name bitop AG can thrive in the harshest habitats one can imagine: salt lakes, deserts, hot springs, the arctic ice or deep sea. With more than 25 years of experience Address Carlo-Schmid-Allee 5 and passion in the manufacturing of 100 % Postal Code/City 44263 Dortmund natural, pure and GMO-free extremolytes, bitop is a global market leader and expert in bitop is a reliable partner for the pharma, Fon +49 231 98 77 44-0 the biotechnological production and devel- animal health, cosmetics and life science Fax +49 231 98 77 44-10 opment of so called extreolytes. industry. We develop unique, extremolyte- E-Mail [email protected] Extremolytes are natural molecules, based medical products and concepts for Internet www.bitop.de which protect biological structures. They human and animal health and offer our raw are found inside of extremophilic plants material as multifunctional cosmetic active Founded (year) 1993 and microorganisms. Protected by ex - ingredients to our worldwide customers.

plied either as API or finished injectables, Name BSV Bioscience GmbH in co-operation with an also GMP approved German license manufacturer. Our main products are: Address Max-Planck-Strasse 12 – Human Chorionic Gonadotrophin (HCG), Postal Code/City 52499 Baesweiler – Human Menopausal Gonadotrophin BSV BioScience GmbH was founded in Oct. (HMG), Fon +49 2401 8047-10 2007 in Baesweiler, near the historical city – Follicle Stimulating Hormone (FSH), Fax +49 2401 8047-198 of Aachen. Since June 2010, the company – Urokinase (UK), Streptokinase and E-Mail [email protected] manufactures and markets biological phar- Ulinastatin (UTI). Internet www.bsvbio.de maceutical active ingredients for different BSV BioScience GmbH is focused on differ- therapeutic areas. ent R&D activities, continuously pursuing Employees 40 One of our key strengths is based on the improvements in the field of API´s and Founded (year) 2007 production of fertility hormones, being sup- finished dosage forms.

53 industrial biotechnology BIO.NRW

for these biomaterials to serve humans Name Cysal GmbH and animals. Cysal’s business strategy aims at out-licensing its technology plat- Address Mendelstraße 11 form to interested companies and/or Postal Code/City 48149 Münster offering its raw materials for incorpora- tion into consumer products for various Fon +49 251 980-2490 The innovative biotechnology company markets. Fax +49 251 980-2499 Cysal GmbH was founded as a spin-out of The main target markets are those for E-Mail [email protected] the University of Münster, Germany. energy food additives and sport nutrition, Internet www.cysal.de Cysal focuses on the production of novel cosmetics and skin care, dental hygiene, biomaterials in the area of biopolymers, clinical nutrition, immunomodulation, Employees 5 peptides, amino acids, and dipeptides on impotence and infertility, as well as in the Founded (year) 2012 an industrial scale at unprecedented low- area of animal feed production, especially cost, and also develops application fields for aquaculture.

pharma industries is offered. Product Name evoxx technologies GmbH development is based on the proprietary technology platform covering the whole Address Alfred-Nobel-Str. 10 value chain from early enzyme and pro- Postal Code/City 40789 Monheim am Rhein cess development to industrial scale pro- evoxx technologies GmbH, a German duction and product deregulation. Fon +49 2173 4099-40 Industrial Biotechnology Company, is evoxx industrial partners and custom- Fax +49 2173 4099-440 focusing on the development and produc- ers benefit from the unique metagenomics E-Mail [email protected] tion of industrial enzymes. As European libraries, the enzyme development skills Internet www.evoxx.com subsidiary of the global enzyme manu- and tech-transfer and production capa- facturer Advanced Enzymes Technologies bilities. evoxx is located on the Creative Employees 25 Ltd. a comprehensive product portfolio Campus in Monheim am Rhein and on Founded (year) 2006 of enzymatic solutions for human nutri- the Biotech Campus Hermannswerder in tion, animal nutrition, bio-processing and Potsdam.

discovery process starting from target Name IMAX Discovery GmbH identification and validation up to the selection and development of new bioactive compounds by providing services, tools Address Otto-Hahn-Str. 15 and integrated solutions tailored to the Postal Code/City 44227 Dortmund client’s and partner’s specific needs. Us- IMAX Discovery is a research driven com ing its strong technology platforms and Fon +49 231 9742-6440 pany, creating new product innovation expertise around taste, olfactory receptors Fax +49 231 9742-7401 through the generation and development and natural products, IMAX Discovery also E-Mail [email protected] of novel and natural ingredients for the generates proprietary product pipelines of Internet www.imaxdiscovery.com food, beverage, perfume and cosmetic natural product based on novel taste and industries. IMAX Discovery offers its cli- fragrance modulators. IMAX Discovery is Founded (year) 2010 ents and partners integrated solutions for a subsidiary of Axxam SpA in Milan, Italy. the entire flavour, fragrance and cosmetic

54 BIO.NRW industrial biotechnology

information content, and are approved for Name m2p-labs GmbH bacterial, yeast, fungi, plant and insect cells. The BioLector® Pro with its microfluidic chip technology, continuously controls the Address Arnold-Sommerfeld-Ring 2 pH value of each culture individually as Postal Code/City 52499 Baesweiler well as the feeding for realizing fed-batch m2p-labs high-throughput microbioreac- cultivations. Fon +49 2401 805-330 tors (BioLector®) provide intelligent, online The microbioreactor systems combined Fax +49 2401 805-333 monitored (biomass, fluorescence, pH and with a standard liquid handling robot E-Mail [email protected] DO) micro fermentation technology for (RoboLector®) allow automated micro fer- Internet www.m2p-labs.com screening and bioprocess development. mentation of the whole bioprocess. The systems increase the number of Employees 42 microbial experiments (aerobic/micro- Founded (year) 2005 aerophilic/strict anaerobic) as well as the

tamination agents for consumer markets, Name multiBIND biotec GmbH hospitals, laboratories and agrochemistry. bioDECONT® and bioCLEAN are the only agents that in addition to the effective kill- Address Gottfried-Hagen-Str. 60-62 ing of microorganisms also accomplish safe Postal Code/City 51105 Köln and complete decontamination and non- enzymatic degradation of genetic material Fon +49 221 2780-211 multiBIND develops innovative decon - (DNA/RNA). Fax +49 221 2780-213 tamination, disinfection and hygiene so- These innovative solutions are nontoxic E-Mail [email protected] lutions for molecular biology, healthcare for humans, non-corrosive and free of or- Internet www.multibind.de and agriculture. The R&D work constantly ganic solvents or other hazardous chemicals. generates exclusive, confidential know- multiBIND pursues a strict partnering strat- Employees 3 how, international patents and new patent egy with international licenses for products Founded (year) 2005 applications for disinfection and decon- in all suitable markets and industrial sectors.

of “Bergischer Abfallverband” in Engel- Name PHYTOLINC skirchen, Germany. For more information, feel free to visit our website or contact us directly (www.phytolinc.com). Phytolinc is a spin-off from the University of Cologne and has developed an innovative Address Ägidiusstr. 14 photobioreactor for microalgae production Postal Code/City 50937 Köln as well as water purification purposes. The unique membrane system enables a highly E-Mail [email protected] efficient cultivation of microalgae, the pro- Internet www.phytolinc.com duction of new algae species and perfectly suits applications in the water treatment Employees 5 industry. Currently, the startup is install- Founded (year) 2017 ing a pilot plant at the waste disposal site

55 industrial biotechnology BIO.NRW

tous fungi, where the company has a Name Senzyme GmbH many years experience and substantial Know How. Address Gierlichsstr. 6 Postal Code/City 53840 Troisdorf

Fon +49 2241 9715-2000 Fax +49 2241 9715-2499 E-Mail [email protected] Senzyme GmbH develops and produces Internet www.senzyme.de technical enzymes and functional feed materials for the bioenergy and animal Employees 42 nutrition markets. Founded (year) 2000 The production process is based on solid-state-fermentation using filamen-

modelling and simulations to successfully Name SeSaM-Biotech GmbH increase your enzyme’s performance. SeS- aM-Biotech tunes enzyme properties like activity, thermal resilience, protease resistance, solvent/pH stability, and substrate/ Address Forckenbeckstraße 50 product inhibition. The track record of 10 Postal Code/City 52074 Aachen years of successful protein engineering includes proteases, monooxygenases, lipases, Fon +49 241 93856979 SeSaM-Biotech is dedicated to the directed cellulases, amylases, phytases, esterases, E-Mail [email protected] evolution of enzymes. Our comprehensive glucose oxidases, pectinases, isomerases, Internet www.sesam-biotech.com evolution strategy KnowVolution as part of laccases, and xylanases being applied in the the QuESt-Service offers the best combi- biotechnological sectors pharma, chemistry, Founded (year) 2008 nation of patented mutagenesis technolo- cosmetics, flavors, nutrients, feed, laundry, gies and rational design by computational food/beverages, biofuel, textiles and paper.

velopment – fermentation – DSP – enzyme Name W42 Industrial Biotechnology GmbH immobilisation – biocatalytic process development. Since 2005 W42 GmbH has carried out many successful projects for industrial Address Otto-Hahn-Straße 15 partners in Europe and P.R. China. Several Postal Code/City 44227 Dortmund W42 GmbH is your partner for enzyme pro- improved strains are running on industrial duction and process development. We offer: scale for production of technical enzymes. Fon +49 176 82182604 High performance heterologous protein Recently W42 has established a European E-Mail [email protected] production in Pichia sp. Wide range of differ- Network for the development, production, Internet www.w42biotechnology.de ent strains and promoters – best choice for licensing and marketing of vaccines for ani- your project. Methanol dependent and cus- mal health with focus on aquaculture sector. Employees 3 tomer specific ‘fine-tuning’ process control Focus is the development of 2nd generation Founded (year) 2005 for high yield protein production. Complete recombinant vaccines. We are offering com- processes are offered including: strain de- plete service for your vaccine candidate.

56 BIO.NRW industrial biotechnology

57 BIO.NRW

Agrobiotechnology

58 BIO.NRW agrobiotechnology

tations. Our patent pending gene therapy Name AgroJector UG technologies will radically improve the pre- cision and safety of crop improvements in generating higher yielding, pest resistant, drought/cold tolerant plants as well as Address Nattermannallee 1 plants with improved nutrition quality and Postal Code/City 50829 Köln The most commonly used tools, including industrial characters. the recently developed genome editing The company aims at introducing desir- Fon +49 176 618 213 95 technologies, are behind the expectations able, lost, wild genes back to highly-bred, E-Mail [email protected] of science and society for genetically im- elite crops or correcting faulty genes in Internet www.agrojector.com proving plants regarding targeting speci- such elite crops. Our technologies are not ficity, full editing capability and stringent limited to plant science but can also po- Employees 2 biosafety. AgroJector is an ag-biotech tentially be applied in human gene therapy. Founded (year) 2014 company focused on addressing these limi-

from pathogens. We developed a patented Name AgroProtect GmbH platform based on antibody fusions which ensures plant protection from fungal and bacterial infections. This alternative approach for controlling plant pathogens and Address Forckenbeckstraße 6 parasites aims at minimising the costs for Postal Code/City 52074 Aachen cultivation of crops thereby reducing the toxic effects of pesticides and toxins for Fon +49 2451 914 8783 It is estimated that plant pathogens are re- human beings. Fax +49 2451 914 8784 sponsible of world-wide losses in the range AgroProtect GmbH licences its propri- E-Mail [email protected] of billions of euros per year. Therefore, etary technology and offers the genera- Internet www.agroprotect.de there is a strong need to provide effective, tion of pathogen resistant plants as well broad range and environmentally friendly as access to novel resistant cultivars of Founded (year) 2010 approaches to ensure protection of plants several crops.

the effect of plant treatments on both di- Name Bex-Biotec GmbH&Co.KG cot and monocot model plants and crops. As contract researchers we screen for interesting candidate substances, optimal application and dosage, as well Address Mendelstr. 11 as plant varieties and species. Postal Code/City 48149 Münster Our assays identify influence on plant growth, stress tolerance (abiotic and/or Fon +49 251 9801190 Bex-Biotec is an emerging start-up biotic) and fruit yield. The flexibility of our E-Mail [email protected] company that is dedicated to support test system enables us to work equally Internet www.bex-biotec.com development processes of new plant with any developmental stage – from treatments. seedling to adult plant. Employees 4 To this end, we offer fast biotechno - Founded (year) 2018 logical plant-based bioassays to evaluate

59 agrobiotechnology BIO.NRW

Phytowelt offers solutions in plant breed- Name Phytowelt GreenTechnologies GmbH ing to improve plants by protoplast fu - sion, genome editing and double haploid Address Kölsumer Weg 33 production. Like this for example biomass Postal Code/City 41334 Nettetal and secondary metabolite production can be optimized. Fon +49 221 669 639-03 Phytowelt operates industrial plant bio- A big poplar collection for biomass Fax +49 221 669 578-361 technology to help unleashing the potential production combined with a unique fer- E-Mail [email protected] of plants. It is a leading provider for the mentation process for terpenes in E.coli, Internet www.phytowelt.com identification and expression of genes especially carotenoids, is a big success fac- encoding plant enzymes. These enzymes tor and USP for Phytowelt. The raspberry Employees 30 offer new possibilities for industrial fer- flavour, R-Alpha-Ionone is Phytowelt`s first Founded (year) 1998 mentation, targeting fatty acids, terpenoids fermentatively produced product and on and plant P450 enzymes. Additionally, the market available product.

rapeseed and other crops is strongly build Name Saaten-Union BIOTEC GmbH upon innovation. Application of tissue culture technologies (doubled haploids, Address Hovedisser Str. 94 embryo rescue) and molecular marker Postal Code/City 33818 Leopoldshöhe applications are routinely used in a wide Fon +49 5208 95971-0 range of crops and for a significant num- Fax +49 5208 95971-96 ber of breeding traits. E-Mail info@saaten-union- biotec.com Internet www.saaten-union- Saaten-Union Biotec offers services biotec.de and contract research in the field of Employees 80 plant breeding (rapeseed, barley, wheat, Founded (year) 1984 triticale, durum, spelt, oat, potato). The development of new varieties of cereals,

60 BIO.NRW

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BIO Clustermanagement NRW GmbH phone: +49 (0) 211 942 150 49 Merowingerplatz 1 mail: [email protected] 40225 Düsseldorf, Germany web: www.bioclustermanagement.de 61 BIO.NRW

Bioinformatics

62 BIO.NRW bioinformatics

hind our software is published. Our trusted Name BioSolveIT platforms SeeSAR and infiniSee support you in structure-based and ligand-based drug discovery and inspire you with new, vivid Address An der Ziegelei 79 ideas. We are passionate about the needs Postal Code/City 53757 Sankt Augustin of our customers and live this through the discovery services we offer. Working together Fon +49 2241 25250 with users in this way helps us to stay at the Fax +49 2241 25255-25 BioSolveIT visualizes drug discovery. Our forefront of current research, addressing E-Mail [email protected] fast and easy-to-use software enables every the questions that chemists are interested Internet www.biosolveit.de chemist to advance their research. Percep- in right now. We aspire to develop software tive visualization helps you to understand that is indispensable to drug discovery and, Employees 17 computational results at a glance. We believe more importantly, software that is a pleasure Founded (year) 2001 in full transparency, and all the science be- to use every day.

The high-throughput techniques performed Name IIT BioTech - Institut für by Illumina HiSeq and MiSeq or by IonTorrent Innovationstransfer an der PGM can be offered combined with a power- Universität Bielefeld GmbH ful lab & bioinformatic pipeline providing full service tasks like genomic assembly, gap Address Universitätsstr. 25 closure and annotation. University of Bielefeld Furthermore we offer individual solutions Postal Code/City 33615 Bielefeld for the bioinformatic evaluation of project Fon +49 521 106 8756 data. This includes construction of draft- Fax +49 521 106 89041 The Institut für Innovationstransfer GB genomics, storage/care of genome projects, E-Mail [email protected] Biotech (IIT Biotech) offers integrated analysis in resequencing and metagenomics Internet www.iit-biotech.de genomic services. Since some years the and development/customization of analysis- Employees 14 main provided service is the “next genera- software. Founded (year) 1995 tion sequencing”.

changes the way infection causative mi- Name Noscendo GmbH crobes are identified. Introducing a para- digm shift using proprietary algorithms and software harnessing next generation sequencing of cell free nucleic acids isolated Address Königstr. 34 from patient samples Noscendo brings the Postal Code/City 47198, Duisburg concept of liquid biopsy into the field of infectious diseases. Fon +49 2066 50687 80 Noscendo’ s software solution is capable of E-Mail [email protected] In order to successfully treat the infected differentiating infection from non-infectious Internet www.noscendo.com patient, you have to recognise and diagnose signals and thereby aiding intensive care most reliably the infecting microbe. clinicians in their daily task to find the right Employees <10 Noscendo GmbH, a Duisburg (Germany) decisions, enabling a targeted and successful Founded (year) 2017 based molecular diagnostics company, treatment in an actionable timeframe.

63 bioinformatics BIO.NRW

Authority (e.g., RKI, RIVM, HPA, Serum Stat- Name Ridom GmbH ens) has bought in the last 10 years and is using since then at least one software product from Ridom. Address Mendelstr. 11 Ridom has pioneered typing efforts with a Postal Code/City 48149 Münster software tool for Staphylococcus aureus. The company has developed and maintains the Fon +49 251 490931-50 The Ridom GmbH (Münster, Germany) was worldwide largest sequence-based microbial Fax +49 251 490931-51 founded January 2003. The company devel- typing database (Ridom SpaServer). The SPA E-Mail [email protected] ops software for DNA re-sequencing analysis typing software Ridom StaphType is currently Internet www.ridom.de for physicians and epidemiologists on routine used by approximately 400 users in 36 dif- basis. The company has in the meantime by its ferent countries worldwide. The new Ridom Employees 4 software products a well-recognized name in SeqSphere+ software provides a bacterial Founded (year) 2003 the field of sequence based microbial typing; typing solution for any bacteria, any study e.g., every European National Health System type, any lab.

64 BIO.NRW bioinformatics

65 BIO.NRW

Other Biotechnologically Active Companies

66 BIO.NRW other

power and create value through innova- Name Bayer AG tion and growth. Bayer is committed to the principles of sustainable development, and the Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2018, the Group employed Bayer is a global enterprise with core around 117,000 people and had sales of Address Kaiser-Wilhelm-Allee 1 competencies in the life science fields of 39.6 billion euros. Capital expenditures Postal Code/City 51368 Leverkusen health care and nutrition. Its products and amounted to 2.6 billion euros, R&D ex- services are designed to benefit people by penses to 5.2 billion euros. For more infor- Fon +49 214 30-1 supporting efforts to overcome the major mation, go to www.bayer.com. Internet www.bayer.com challenges presented by a growing and aging global population. At the same time, Employees 117,000 the Group aims to increase its earning

turf grasses, and different intercrop spe- Name Deutsche Saatveredelung cies. Breeding is run on nine breeding AG (DSV) stations in Europe and two in Canada. We are dedicated to our purpose: Innovation Address Weissenburger Straße 5 for your growth. Seed of new varieties is Postal Code/City 59557 Lippstadt produced and processed mostly in Europe Deutsche Saatveredelung AG is an inter- and sold world-wide. Fon +49 2941 296-0 national plant breeding company with In the framework of several coopera- Fax +49 2941 296-100 headquarters in Germany. The main focus tions in breeding, production, marketing E-Mail [email protected] is on research and development in breed- and sales DSV is partner of several com- Internet www.dsv-seeds.com ing and seed production for different crop petitive enterprises on the national and plant species. international level. Presently, DSV Group Employees 600 Our major products include rapeseed, employs around 650 people and has a Founded (year) 1923 wheat, barley, corn/maize, pasture and turnover of around EUR 200 million.

vative prowess and integrated technology Name Evonik Industries AG platforms. Evonik is active in over 100 countries around the world. In fiscal 2015 more Address Rellinghauser Str. 1-11 than 33,000 employees generated sales Postal Code/City 45128 Essen Evonik, the creative industrial group from of around €13.5 billion and an operating Germany, is one of the world leaders in profit (adjusted EBITDA) of about €2.4 Fon +49 201 177 01 specialty chemicals. Profitable growth billion. Fax +49 201 177 3475 and a sustained increase in the value of Evonik innovates and serves the bioec- E-Mail [email protected] the company form the heart of Evonik’s onomy markets. Products are i. a. Biolys®, Internet www.evonik.com corporate strategy. Its activities focus DYNACOLL® Terra, DYNAPOL ® Terra, on the key megatrends health, nutrition, RESOMER®, ThreAMINO®, TrypAMINO®, Employees 33,000 resource efficiency and globalization. and VESTAMID® Terra. Founded (year) 2007 Evonik benefits specifically from its inno-

67 other BIO.NRW

The main focus is on oilseed rape, potatoes, Name German Seed Alliance GmbH corn, sunflower, grasses, peas and cereals (especially wheat, barley, rye, oat and Address Aachener Str. 1053-1055 triticale). German Seed Alliance coordinates Postal Code/City 50858 Köln all research programs of the group and is German Seed Alliance GmbH is an alliance partner of the national and international Fon +49 221 162 506-0 of four leading German plant breeding scientific community in plant research and Fax +49 221 162 506-29 companies in international agriculture: biotechnology. New varieties are developed E-Mail [email protected] Deutsche Saatveredelung, Norddeutsche and high quality seeds are produced for dif- Internet www.german-seed-alliance.de Pflanzenzucht, Nordsaat Saatzucht and ferent climate regions. In sales the first focus SaKa. The company and its shareholders are is on Russian Federation, with innovative Employees 45 internationally experienced enterprises in solutions and wide range of seed products Founded (year) 2008 the field of plant research and development, combined with professional service and breeding, seed production and distribution. individual consultancy.

record of bringing innovative pain treat- Name Grünenthal GmbH ments and state-of-the-art technologies to patients. By sustainably investing in our R&D above the industrial average, we are Address Zieglerstr. 6 strongly committed to innovation. Postal Code/City 52099 Aachen Grünenthal is an independent, family- Grünenthal is an entrepreneurial, science- owned company headquartered in Aachen, Fon +49 241 569-0 based pharmaceutical company specialized Germany. We are present in approx. 30 E-Mail [email protected] in pain, gout and inflammation. Our ambi- countries with affiliates in Europe, Latin Internet www.grunenthal.com tion is to deliver four to five new products America and the US. Our products are sold to patients in diseases with high unmet in more than 100 countries and approx. Employees 5,200 worldwide medical need by 2022 and become a € 2 bn 5,200 employees are working for Grünenthal Founded (year) 1946 company. We are a fully integrated research worldwide. In 2017, Grünenthal achieved & development company with a long track revenues of approx. € 1.3 bn.

In its Laundry & Home Care and Beauty Name Henkel AG & Co. KGaA Care businesses, Henkel holds leading positions in many markets and categories around the world. Founded in 1876, Hen- Address Henkelstr. 67 kel looks back on more than 140 years of Postal Code/City 40191 Düsseldorf Henkel operates globally with a well- success. balanced and diversified portfolio. The Henkel employs more than 50,000 Fon +49 211 7979 630 company holds leading positions with its people globally and reported sales of Fax +49 211 7982 245 three business units in both industrial and 20,0 bn euros in fiscal year 2017. Henkel’s Internet www.henkel.com consumer businesses thanks to strong preferred shares are listed in the German brands, innovations and technologies. stock index DAX. Employees 50,000 Henkel Adhesive Technologies is the Founded (year) 1876 global leader in the adhesives market – across all industry segments worldwide.

68 BIO.NRW other

RNA, and viral nucleic acids is based on the Name PerkinElmer chemagen use of proprietary M-PVA Magnetic Beads Technologie GmbH in combination with our high-performance instruments. Address Arnold-Sommerfeld-Ring 2 chemagen has developed numerous kits Postal Code/City 52499 Baesweiler for the isolation of nucleic acids from various sample materials such as blood, serum Fon +49 2401 805500 PerkinElmer chemagen Technologie GmbH or plasma, tissue, saliva, buccal swabs, Fax +49 2401 805519 is a key player in the field of automated amniotic fluid or stool samples. PerkinElmer E-Mail support.chemagen@ nucleic acid isolation with vast experience chemagen routinely develops customized perkinelmer.com in the field of DNA and RNA isolation for solutions addressing any specific require- Internet www.chemagen.com human genetics, HLA typing, blood banking, ments for DNA or RNA purification in close Employees >40 and pathogen detection. chemagen’s tech- coordination with clients. IVD versions of Founded (year) 1997 nology for the purification of genomic DNA, instruments and kits are available.

an “Excellence company for Training and Name Pharma Waldhof GmbH Talent Management”. Development of new products using cutting-edge technology enables us to apply our high standards and Address Hansaallee 159 quality values into innovative, powerful and Postal Code/City 40549 Düsseldorf Since 70 years, Pharma Waldhof GmbH, lo- well-accepted products designed for existing cated in Düsseldorf/Germany, is active in the and new markets. Fon +49 211 52602-0 unique world of Nucleic Acid Biochemistry. Our success is based on our highly skilled Fax +49 211 52602-60 The last milestones in our long company people and pursuit for delivering quality E-Mail [email protected] history were in 2014 and 2016 the award of value added products serving the worldwide Internet www.pharmawaldhof.de the label “Innovative through Research” by market in various segments like Pharma APIs the “Stifterverband für die deutsche Wis- and Intermediates; Cosmetics; Nutrition and Employees 13 senschaft” and in 2015 the acknowledge- Diagnostics. Pharma Waldhof belongs to the Founded (year) 1974 ment by the “Deutscher Bildungspreis” as multi-national Aceto Group/USA.

enhancing biodiversity and revitalizing Name Syngenta Seeds GmbH rural communities. To learn more visit www.syngenta.com and www.goodgrowthplan.com. Follow Address Zum Knipkenbach 20 us on Twitter® at www.twitter.com/Syn- Postal Code/City 32107 Bad Salzuflen Syngenta is a leading agriculture company genta. helping to improve global food security Fon +49 5222 5308-0 by enabling millions of farmers to make E-Mail internet.marketing@ better use of available resources. syngenta.com Through world class science and inno- Internet www.syngenta.de vative crop solutions, our 28,000 people in over 90 countries are working to trans- Employees 150 form how crops are grown. We are com- Founded (year) 2000 mitted to rescuing land from degradation,

69 other BIO.NRW

diseases. The complexities of severe Name UCB Pharma GmbH UCB Biosciences GmbH diseases are beyond the expertise and resources of a single organisation. Developing and commercialising in Address Alfred-Nobel-Str. 10 novative therapies is often the result of Postal Code/City 40789 Monheim UCB is a global biopharmaceutical com strong partnerships. That is why we value pany with around 7,500 people worldwide. partnering with leading academic, biotech Fon +49 2173 4848-48 We focus on neurology and immunology and pharma companies to bring new solu Fax +49 2173 4848-41 disorders – putting patients at the center tions for patients. There is no such thing E-Mail [email protected] of our world. UCB is connecting science in as an “average patient”. We are seeking to Internet www.ucb.com; www.ucb.de new ways, notably chemistry and biology, embed the real needs of specific patient so that they can leverage the potential of populations in our science and innovation Founded (year) 1928 (Belgium) these two disciplines, as well as illuminate process.

the biological pathways involved in severe

C N WvB is nowadays well known for strong

Name W. von Borries-Eckendorf E

GmbH & Co. KG K breeding programs in oilseed rape, barley T Pflanzenzuchtbetrieb E and high yielding wheat varieties.

N R The company based in Lippe is founding

Address Hovedisser Strasse 94 D O member of the Rapool Ring GmbH and the Postal Code/City 33818 Leopoldshöhe O S Saaten-Union Biotec GmbH. R Fon +49 5208 9125-30 F E R Along with other breeding companies, Fax +49 5208 9125-49 Eckendorf is significantly involved in one E-Mail [email protected] of the largest distributors in the German Internet www.wvb-eckendorf.de W. von Borries-Eckendorf is a medium-sized sector of seed, the Saaten-Union GmbH. family-owned company, founded in 1849 by Employees 40 Wilhelm von Borries (1805-1890), a promi- Founded (year) 1849 nent farmer and talented plant breeder. Starting with the “Eckendorfer” fodder beet,

70 BIO.NRW other www.bio.nrw.de company database

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aquila biolabs GmbH Biotech- Baesweiler, North Rhine-Westphalia, Germany

Unternehmen Main Sector Description Supplier & Engineering aquila biolabs is a German technology in Nordrhein- company that focuses on the Herzlich Willkommen development of laboratory devices for Subsector the analysis of shake-ﬂ ask Westfalen • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, in Nordrhein-Westfalen biotechnological and chemical research to better understand, dem (Bundes)land der Biotechnologie Company name optimize and control their bioprocesses.

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Ares Bioscience GmbH Main sector Köln, North Rhine-Westphalia, Germany Biotechnology - Therapeutics and Diag… Main Sector Description Biotechnology / R&D Services Ares Bioscience GmbH is a Subsector [select all] Cluster BIO.NRW Biotech Standort NRW Startups & Finanzierung biotechnology company which Analytical services develops and markets molecular Subsector biology products to life sciences BIO.NRW aktiviert Kooperationen zwischen …ist eine sich dynamisch entwickelnde Technologie BIO.NRW.red als strategische Initative für ein Biochips • Other market. The company provides PCR Forschung, Unternehmen, Investoren und Politik aus den in NRW traditionell starken Industrien stabiles und dauerhaftes Netzwerk aus Experten • Analytical services Bioinformatics enzymes, restriction enzymes, auf Landesebene, national und international. Energie, Stahl und Chemie. der roten Biotechnologie. • Synthesis services nucleotides, DNA/RNA modifying Cell culture enzymes, DNA molecular weight markers, products for molecular Diagnostic Instrumentation biology, and reagents for mehr erfahren mehr erfahren mehr erfahren electrophoresis. Genomics

Primary therapeutic areas [select all] Show Details Cardiovascular Aktuelles Conditions originating in the perinatal pe… Congenital malformations, deformations… Aktuelle Nachrichten Digestive system arrows biomedical Deutschland GmbH Diseases of the blood and blood-forming… Köln, North Rhine-Westphalia, Germany

Diseases of the ear Diseases of the blood and blood-forming…

Wissenschaft und Wirtschaft BIO.NRW Cluster Main Sector Köln, North Rhine-Westphalia,Description Germany

arrows biomedical Deutschland GmbH Digestive system Biotechnology / R&D Services arrows biomedical Deutschland GmbH

Business Model [select all] is a service laboratory with emphasis 12. Juni 2017 07. Juni 2017 Congenital malformations, deformations… on gene and protein analysis, Other

NRW-Investitions- und Delegation der China Medical City Subsector Pyrosequencing® technology, cell Conditions originating in the perinatal pe… • Other Kooperationsscout nimmt Arbeit in Tel unterzeichnet Memorandum of In-licensing culture management, HPLC / MS

• Analytical services

Aviv auf Understanding Cardiovascular analysis and bioinformatics. The

Manufacturer • Biochips services oﬀ ered by the company

[select all] Primary therapeutic areas • Bioinformatics Show Detailsinclude Gene and protein analysis Out-licensing • Cell culture ( Microarray s), RT-qPCR / general PCR,

09. Juni 2017 06. Juni 2017 Pyrosequencing ® Technology, HPLC /

Genomics R&DGenomics • Diagnostic instrumentation

MS,...electrophoresis.

Max-Planck-Institute feiern Fit für die Zukunft? • Genomics

biology, and reagents for

Diagnostic Instrumentation ResearchDiagnostic on Instrumentation contract basis

Millionenförderung vom Europäischen BIO.NRW.academy am 3. Mai in Hamm • Proteomics

markers, products for molecular

Innovative biotech companies in North Rhine-Westphalia. BIO.NRW offers free ofmarkers, charge products for molecular a well-or-

Cell culture Forschungsrat enzymes, DNA molecular weight

nucleotides, DNA/RNA modifying • Synthesis services

Customer segments [select all] • Synthesis services

Bioinformatics

Show Detailsenzymes, restriction enzymes,

Other • Analytical services

08. Juni 2017 05. Juni 2017 market. The company provides PCR • Other Biochips

biology products to life sciences ganized and comprehensive database of life science and biotechConsumer (mass market) companiesSubsector resident in North Rhine-

EU-Darlehen für Biofronteras Nachbericht - Die Deutschen

develops and markets molecular Analytical services

Wachstumskurs Biotechnologietage 2017 – Hospitals biotechnology company which

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Biotechnology / R&D Services 05. bis 06.04.2017 in Hannover Ares Bioscience GmbH is a

Large biotech and big Pharma Main Sector

Westphalia. The database currently includes 450 company proﬁ les, contact detailsaquila biolabsDescription andGmbH a summary of BiotechnologyLarge medtech - Therapeutics and Diag…

Baesweiler, North Rhine-Westphalia, Germany

Main sector

Köln, North Rhine-Westphalia, Germany Physicians / doctors Köln, North Rhine-Westphalia, Germany

Ares Bioscience GmbH Alle Nachrichten Ares Bioscience GmbH Main Sector Description products, services and technologies and is updated frequently several timesSupplier & Engineering per year.aquila biolabs is a German technology Distribution [select all]

company that focuses on the FreeDirect text (own sales force) development of laboratory devices for

Subsector the analysis of shake-ﬂ ask AdvancedIndirect (independent Search dealer)

• Laboratory equipment fermentations. The company enables

Show Details Show Detailsscientists in pharmaceutical, Veranstaltungen Biotech [select all] Medtech [select all] biotechnological and chemical research to better understand, Preclinical In development

optimize and control their phone: +49 211 38 54 69-9200 • E-Mail: [email protected].

Phase I On the market bioprocesses.

Kommende Veranstaltungen optimize and control their CompanyPhase nameII

Phase III research to better understand, biotechnological and chemical

On the market Show Detailsscientists in pharmaceutical,

BIO International Convention 2017

fermentations. The company enables

19. - 22. Juni Westfalen • Laboratory equipment

the analysis of shake-ﬂ ask

2017 The Government of the German State of North Rhine-Westphalia (NRW) and BIO.NRW Cluster Employees at domicil Subsector

Biotechnology NRW cordially invite you visit us at our booth (4507) in the German Pavilion. 50 200 development of laboratory devices for in Nordrhein-

company that focuses on the

Supplier & Engineering aquila biolabs is a German technology

Main Sector Description

San Diego Convention Center, USA 06 Konversationen EmployeesUnternehmen worldwide arrows biomedical Deutschland GmbH

0 100.000 Köln, North Rhine-Westphalia, Germany

Biotech- Baesweiler, North Rhine-Westphalia, Germany

13. Arbeitsplattform „Liquid Biopsy" Main Sector aquila biolabsDescription GmbH 05. Juli Ownership [select all] Biotechnology / R&D Services arrows biomedical Deutschland GmbH

is a service laboratory with emphasis

2017 13. Arbeitsplattform des thematischen Schwerpunktes BIO.NRW.red zum Thema Private / independent

57 Ergebnisse sortiert nach Firmennamen Firmenname „Liquid Biopsy – Vom Analyten über die Analytik zur Anwendung“ ﬁndet am Mittwoch, den on gene and proteinSortieren analysis, nach: Subsector 05.07.2017, ab 12:30 Uhr im Centrum für Nanotechnolog Public (listed on stock exchange) Pyrosequencing® technology, cell • Other culture management, HPLC / MS

Subsidiary • Analytical services Veranstaltungen Standort Finanzierung Kontakt Aktuelles analysis and bioinformatics. The CeNTech, Münster 12 Konversationen • Biochips services oﬀ ered by the company • Bioinformatics include Gene and protein analysis Search Clear • Cell culture ( Microarray s), RT-qPCR / general PCR,

• Diagnostic instrumentation Pyrosequencing ® Technology, HPLC /

Newsletter-Anmeldung CLIB-HiPerIn Forum “Biotech Innovations for Coatings” MS,... OK 06. Juli • Genomics 2017 Das nächste CLIB Forum befasst sich mit biotechnologischen Innovationen für Beschichtungen. • Proteomics

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13. Juli Marktchancen Japan / Südkorea aquila biolabs GmbH Japan und Süd-Korea sind wichtige Absatzmärkte und Investitionsstandorte für die deutsche 2017 Baesweiler, North Rhine-Westphalia, Germany Industrie. Insbesondere im Bereich der Gesundheitswirtschaft tun sich für NRW-Unternehmen große Chancen auf. Main Sector Description ZENIT GmbH, Mülheim an der Ruhr 09 Konversationen Supplier & Engineering aquila biolabs is a German technology company that focuses on the development of laboratory devices for Subsector the analysis of shake-ﬂ ask • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, Alle Veranstaltungen biotechnological and chemical research to better understand, optimize and control their bioprocesses.

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aquila biolabs GmbH Baesweiler, North Rhine-Westphalia, Germany

Main Sector Description Supplier & Engineering aquila biolabs is a German technology company that focuses on the development of laboratory devices for Subsector the analysis of shake-ﬂ ask Biotech-Unternehmen • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, in Nordrhein-Westfalen biotechnological and chemical research to better understand, optimize and control their Firmenname bioprocesses.

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BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der Life Science und Biotechnologiefirmen aus Nordrhein-Westfalen Life Science und Biotechnologiefirmen aus Nordrhein-Westfalen zur Verfügung. Die zur Verfügung. Die Information umfasst Firmenprofile, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien. Information umfasst Firmenprofile, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien.

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This academic database is the ﬁrst of its kind in Germany and aims to facilitate collaboration between industry and academia. The database is being launched in fall 2010 In unserem Downloadcenter ﬁnden Sie Publikationen, Vorträge und by Venture Valuation and BIO.NRW. There are currently over 1000 working groups in North Präsentationen zum Download. Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Rhine Westphalia listed. The organizations are currently in the process of up-dating and Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et complementing their data. magnis dis parturient montes, nascetur ridiculus mus.

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BIO.NRW The Home of Biotech … in North Rhine-Westphalia

North Rhine-Westphalia is situated at Eu- dialogue between all stakeholders in the biotech developments in NRW please visit rope’s geographic and economic center. It field of biotechnology and to encourage www.bio.nrw.de. is the largest of Germany’s 16 federal states cooperation. and a leading exporter. If classified as an Further drivers in the field are dynamic local independent exporting nation, NRW would Biotech Business & Sciences biotechnology initiatives and networks: rank 29th in the world between Czech Republic BIO.NRW compiles comprehensive and and Austria. current online databases of the academic Bioanalytik-Münster North Rhine-Westphalia’s state govern- institutions and companies active in the life www.bioanalytik-muenster.de ment has established a number of technology sciences in NRW. Free to access and easy- clusters to systematically improve NRW’s to-use, these resources are valuable tools for BioCologne strengths and talents in established industries identifying prospective business partners. www.biocologne.de and up-and-coming fields like biotechnology. More information on www.bio.nrw.de North Rhine-Westphalia’s biotechnology bio.dortmund network BIO.NRW is a central catalyst for Fairs, Exhibitions and Conferences www.wirtschaftsfoerderung-dortmund.de the sustainable development of the state’s Companies and academic institutions can biotech sector. It activates cooperation generate awareness of their activities locally, BioIndustry between business, research, investors and nationally and internationally by being a part www.bioindustry.de policy-makers. BIO.NRW also promotes the of the BIO.NRW common stands on fairs, strengths and achievements of biotechnology exhibitions and conferences. BIO.NRW also BioRiver in the state. organizes a series of workshops and sympo- www.bioriver.de sia, called BIO.NRW.academy. To support young as well as already estab- LifeScienceNet Düsseldorf lished biotech companies, BIO.NRW offers Support of Young Professionals www.lifescience-dus.de the following core competencies: BIO.NRW takes a special interest in support- – Individual matchmaking for collabora- ing young professionals in biotechnology. MedLife (Aachen) tions and partners We participate in conventions and exhibi- www.medlife-ev.de – Overview on all up-to-date R&D activi- tions to bring graduates in contact with ties in industry and academia representatives from industry and academic Cluster Industrial Biotechnology – Profound knowledge on financing pos- science. The ‘Business Angel Network – BIO. www.CLIB2021.com sibilities NRW’ helps financing and funding biotech – International promotion and marketing start-ups. In addition, a forum that brings for NRW as biotech location together investment institutions, private – Direct contacts to decision makers investors and business angels and develop- ers provides information about the current Our services include NRW biotech scene. These meetings are a valuable opportunity for start-up companies Technology Transfer to receive coaching and financing. Tech transfer support is a key contribution from BIO.NRW. We organize events, work- To learn more about the Cluster BIO.NRW ing platforms and meetings to promote the and to stay informed about the latest

72 Denmark BIO.NRW

Kiel Hamburg

Bremen Schwerin Netherland Berlin Poland

Magdeburg

Hannover Potsdam

j Düsseldorf

Dresden Belgium Erfurt Frankfurt

Luxembourg Mainz Czech Republic

Saarbrücken

Stuttgart

France München Austria

Switzerland 73 BIO.NRW

Glossary

Organisation for Economic Other biotechnologically active Contact BIO.NRW Co-operation and Development companies (OECD) Dr. rer. nat. Nils Schrader … firms that apply biotechnology techniques Head of office BIO.NRW The OECD is a unique forum where the gov- for the purpose of implementing new or sig- Merowingerplatz 1 ernments of 30 democracies work together nificantly improved products or processes. 40225 Düsseldorf, Germany to address the economic, social and environ- This definition excludes end users that Fon +49 211 385469-9203 mental challenges of globalisation. innovate simply by using biotechnol - Fax +49 211 385469-9220 The OECD Biotechnology Statistics, which ogy products as intermediate inputs (for [email protected] brings together the latest available economic instance, detergent manufacturers that www.bio.nrw.de and activity data on biotechnology and in- change a formulation to include enzymes novation, is collected by OECD member and produced by other firms via biotechnology non-member countries. techniques). The report builds on the extensive work of the OECD and national experts to im - Business Areas of Activity prove the comparability of biotechnology statistics. – Health/Medicine www.oecd.org (including animal health) Development of therapeutics and/or diagnostics for the field of human medicine, drug OECD Definitions delivery, human tissue replacement. – Agri/Agrobiotechnology Biotech focussed on genetically modified Biotechnology company plants, animals or microorganisms, as well as non-genetically modified plants grown … is defined as a application of science and using biotechnological procedures for use in technology to living organisms, as well as agriculture or forestry. parts, products and models thereof, to alter living or non-living materials for the produc- – Industrial biotechnology tion of knowledge, goods and services. Biotechnological products and processes for the handling of waste or sewage, for chemical Dedicated biotechnology synthesis, for the extraction of raw materials companies and energy, etc.

… are defined as biotechnology active firms – Non-specific application whose predominant activities involve the Equipment or reagents based on biotechno- application of biotechnology techniques to logical principles for research or provision of produce goods or services and/or the per- services in this field (“ancillary industry”). formance of biotechnology R&D. Source: biotechnologie.de

Online Company Company Database Directory www.bio.nrw.de

BIO.NRW Merowingerplatz 1 40225 DuesseldorfDüsseldorf, Germany Germany Fon +49 211 385469-9200 Fon + 49 (0) 2 11 385 469 - 9200 Fax +49 211 385469-9220 Fax + 49 (0) 2 11 385 469 - 9220 [email protected] www.bio.nrw.de

Ministry of EconomicInnovation, Affairs, Science, Innovation, ResearchDigitalization and andTechnology Energy ofof the the State Stateof North of NorthRhine-Westphalia Rhine-Westphalia 4022140213 DüsseldorfDuesseldorf www.innovation.nrw.de www.wirtschaft.nrw www.exzellenz.nrw.de ‘Excellence NRW’ stands for the cluster strategy in North Rhine-Westphalia, an innovative location for business. The state government www.bio.nrw.de Spot on Biotechnology Business 2019/2020 there wants to improve on its strengths, and systematically strive for excellence in NRW. The goal of the cluster policy is to create an environment that is friendly to innovation, strengthens the competitive edge of the businesses there, and stimulates growth and employment. To find out more about NRW’s cluster strategy and the 16 clusters in the state, just visit: www.exzellenz.nrw.de