Spot on Biotechnology Business 2018/2019

of NorthRhine-Westphalia Digitization andEnergy of theState Ministry of Economic Affairs, Innovation, www.bio.nrw.de [email protected] Fax Fon 40225 Düsseldorf, Germany Merowingerplatz 1 BIO.NRW www.wirtschaft.nrw 40213 Düsseldorf +49 211385469-9220 +49 211385469-9200

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www.bio.nrw.de Spot onBiotechnology Business 2018/2019

Company Directory

From Mind to Market: Biotechnology Company Directory 2018/2019 North Rhine-Westphalia BIO.NRW

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Editorial

Dear Reader, cessful ecosystems that risk capital is a key factor. As state politicians, however, we must North Rhine-Westphalia plays a leading also endeavor to exert a positive influence on role in biotechnology – one of the key tech- factors such as the prestige of entrepreneur- nologies of this century. In 2017, sales of ship, risk culture in general and the provision the North Rhine-Westphalian biotech sector of appropriate skills for company start-ups. rose by around 15 percent to more than 2 Contact between start-ups and corporates billion euros. This means that biotechnology must become a matter of course. in NRW accounted for more than half of the We have set up a “NRW Pharma Dialogue” industry’s sales in Germany. Biopharma- in which experts from industry, science and ceutical therapy options are particularly associations develop action recommenda- important in the treatment of cancer and tions for NRW as a pharmaceutical and bio- other age-related diseases. Important im- tech location and expand on digitization as petus within the industry is provided by the an outstanding cross-sectoral topic. two leading companies Qiagen and Milte- Right at the beginning of this legislative pe- nyi, which are both based in North Rhine- riod, we approved additional venture capital Westphalia. As a cross-sectional scientific of 214 million euros for NRW.Bank’s seed and area, the impact of biotechnology extends start-up investments, thereby increasing the far beyond the life science sector. volume by 85 percent. From my work as Minister for Innovation, In order to strengthen the research power Science, Research and Technology between and start-up culture at universities and 2005 and 2010, I am also aware of the enor- ultimately the entire regional start-up eco- mous importance of our science and research system, we are going to support the estab- landscape for the further development of the lishment of Excellence Start-up Centers with industry. In 2009, at the beginning of the Bio- We will continue to systematically strengthen up to 150 million euros. The goal is to make Cluster activities, I was already in a position the research priorities developed by uni - North Rhine-Westphalia the number one to present North Rhine-Westphalia at the versities and research institutions on their start-up state. industrial fair BIO International Convention in own initiative. In order to support research Our key biotechnology sector will clearly Atlanta as a top location for biotechnological activities by industry, we have launched a benefit from these and other measures im- research. With 25 universities and colleges Bundesrat initiative to promote tax breaks plemented by the state government in the and 30 other research institutes focusing for research, in addition to project funding. coming years. on life sciences, we had and still have an North Rhine-Westphalia is already a state extraordinarily strong and diverse teaching with new ideas, innovative start-ups and a and research program. lively founders’ scene – something we want Despite the positive development of the to expand on further. industry we are not sitting back and taking What is particularly close to my heart is things easy but have formulated our ambi- the strengthening of the start-up culture tious goal in the coalition agreement to be- through better framework conditions for new Prof Dr Andreas Pinkwart come the frontrunner in biotechnology. We businesses and their founders. More than have described the measures by which we ever, we need a new “Gründerzeit” in North Minister of Economic Affairs, Innovation, intend to achieve this goal. I would now like Rhine-Westphalia. It has emerged from many Digitalization and Energy of the State of to highlight a few of them. discussions at home and abroad on suc - North Rhine-Westphalia

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Greeting

Dear Reader, ther into the growth phase through EU and global cooperation. One of the next steps is In this ninth edition of the “Spot on Bio - our move to China with the new cooperation technology Business” brochure, I would project “ChInValue”. Additional potential of- like to look back on the development of the fered by bioinformatics and artificial intelli- biotechnology hot spot region NRW over the gence facilitates fields of action for the future. past 10 years and will be addressing some For NRW-based companies, I would like to see topics for the future. more readiness for intensive collaboration as BIO.NRW was launched at the beginning more risk-taking is needed in order to lever- of 2009 as part of the cluster policy of the age synergy potential. In general, we will have then state government. In May 2009, I ac- to develop ways to make the ecosystem even companied the Minister for Innovation, Sci- more closely interlinked in order to expand ence, Research and Technology, Professor the sustainable BIO.NRW network. Therefore, Pinkwart, to the world’s largest biotechnol- we are also looking forward to suggestions ogy trade fair “BIO International Conven- and initiatives from the community with tion” in Atlanta (USA). Biotechnology was regard to the coming years. one of four fields of technology on which Insufficient VC financing also remains a the Ministry of Innovation in NRW concen- considerable hurdle for NRW. We will there- trated its research funding. In retrospect, stakeholders. We support technology trans- fore carry on with our toolbox of financing the this was the right move. Biotech industry fer, particularly for biotech start-ups, with start-ups. 49% of all venture capital-backed sales in Germany grew from 2,184 billion coaching and financing. biotech investments in Europe in 2016 were euros in 2009 to 4,105 billion euros in 2017, One highlight is our annual International made in the UK and Switzerland (EY Bio - an increase of 88 %, more than twice as BIO.NRW Business Angel Congress. The aim technology Report 2017 Beyond borders). In much as the gross domestic product (36 %) is to supply the highly diverse investors’ com- order to break the bottleneck of structural in the comparison period. munity of business angels, venture capital- underfinancing, we would finally like to see Our activities at BIO.NRW have grown ists, institutional investors and their potential more concise and sustainable solutions from continuously over the years and the umbrel- clients with the most up-to-date finance and those responsible in the finance, economics la brand BIO.NRW is now firmly established investment information. NUMAFERM GmbH and science ministries in Berlin, especially in in science and industry. We view ourselves from Düsseldorf is a current success story regard to taxing investments. as a central dialogue platform between which was financed by participants in our business, research, investors and politics. Business Angel Circle and has just been voted This means that we take part in national and one of “Germany’s Start-up Kings” (“Bilanz” international fairs, exhibitions, and confer- business magazine). NUMAFERM’s patented ences. We analyze the biotechnology sector process can reduce the production costs of in North Rhine-Westphalia in terms of busi- peptides substantially and ecologically and ness data as well as conducting marketing be applied to all the various biotech sectors. and PR. We offer the promotion of young This is a perfect example of NRW acting as a Dr. Bernward Garthoff academics and online job platforms. Our biotech hot spot! However, further efforts are Cluster BIO.NRW focus is on collaboration with organiza - needed to consolidate the positive develop- tions such as EIT Health and with both lo- ment in the state. Representative for Biotechnology of the cal and international companies, research After an implementation and expansion German State of North Rhine-Westphalia institutions, financiers and other biotech phase, BIO.NRW will develop its network fur-

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Content

Editorial… ……………………………………………………………………………… 5 Company Directory 2018/2019 NRW

Greeting… ……………………………………………………………………………… 7 Non-specific Services… …………………………………………………… 28

Spot on Biotechnology Business… ………………………………… 11 Health and Medicine (including Animal Health)… …… 38

Biotech Landscape……………………………………………………………… 11 Industrial Biotechnology… ……………………………………………… 52

Stimuli for Start-Up‘s… ……………………………………………………… 11 Agrobiotechnology… ………………………………………………………… 58

Academic Biotech Research … ……………………………………… 13 Bioinformatics… ………………………………………………………………… 62

Biotech Business… …………………………………………………………… 15 Other Biotechnologically Active Companies……………… 66

Competence Clusters… …………………………………………………… 21 BIO.NRW Cluster Biotechnology North Rhine-Westphalia… ……………………………………………… 72 Industrial Biotechnology – CLIB2021 ……………………………… 21 Glossary… …………………………………………………………………………… 74 Pharmaceutical Biotechnology – BIO.NRW.red … …… 23 OECD Definition… ……………………………………………………………… 74 From Mind to Market … …………………………………………………… 23 Organisation for Economic Co-operation and Development (OECD)… …………………………………………………… 74 Biotechnology Map of North Rhine-Westphalia Life Science Technology Parks and Incubators… …… 24 Biotechnology company… ……………………………………………… 74

Dedicated biotechnology companies … ……………………… 74 Biotechnology Map of North Rhine-Westphalia Dedicated and other biotechnologically active Other biotechnologically active companies… …………… 74 companies … ……………………………………………………………………… 26 Business Areas of Activity… …………………………………………… 74

Contact BIO.NRW……………………………………………………………… 74

Sources, Literature, Links… …………………………………………… 74

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Spot on Biotechnology Business

Biotech Landscape Colognes “Koelnmesse” is the No.1 venue promote the industry, including venture for more than 25 different industries. capital providers and business development North Rhine-Westphalia (NRW) is at the Traditionally, North Rhine-Westphalia has organizations. heart of Europe. 160 million people – almost been Germany’s most important location for Biotechnology in NRW represents an active, a third of the population of the European Un- the pharmaceutical and chemical industry. multicentric network, which is setting the ion – live within a day’s drive of Düsseldorf, Today the state has also developed into a life pace for the powerful pulse of the state’s life the state capital. 31.8 percent (i.e. 180.9 sciences hotspot: A good reason for many science business. Meanwhile biotechnology billion euros in 2015) of the direct foreign top-level biotechnology companies and re- is a maturing industry that expands rapidly. investment that flows into Germany ends search institutes to have their headquarters Its innovative technologies are applied to up in North Rhine-Westphalia, where some here. Numerous successful start-up and major industry branches serving health/ 19.000 international companies control spin-off companies are flourishing in NRW medicine, chemistry, food and environment. their German and European operations alongside a strong chemical and pharmaceu- North Rhine-Westphalia has been developing from. NRW also is the number one trading tical industry that includes many well-known its biotechnology hotspot since 1995. More state among Germany’s 16 federal states. 1 household names like Bayer, Evonik, Henkel, than 20 years into the program, over 450 life Summing up the in- and export of NRW the Grünenthal, Johnson & Johnson or UCB. science related companies are located here trading volume in 2016 is 386 billion eu - This business excellence is endorsed by – among them 128 biotechnology enterprises ros.2 With around 692 billion euros in 2017, a dense network of outstanding academic including several global players (Figure 1). NRW generates 21.2 % of the German GDP, institutions, which focus on biotechnology Major business areas covered are industri- putting it clearly at the top of all German within a broad life sciences landscape. In al, nano- and pharmaceutical biotechnology, federal states.3 addition, there is an equally rich and ro - and there is a focus on enabling technologies It accounts for 4.4 percent of the Europe- bust funding environment to support and and supporting services as well. Combining an GDP (EU-28), making it one of the most the strong technical expertise evolving from important economic regions in Europe. these areas has been the key driver for NRW Comparing NRW in an international ranking, as the state is pioneering the field of bio- it is ahead of several European countries economy in Germany. such as Switzerland, Sweden, Poland, and 108 dedicated 1 Belgium. With 17.9 million inhabitants of biotechnology Stimuli for Start-Up‘s which 9.6 million live in the Rhine-Ruhr area, companies that lists among the top 20 metropolitan Many of today’s successful young biotech areas in the world – NRW is by far the most 20 other companies started as university spin-offs. populous German state.4 biotechnologically They took advantage of life science incuba- active companies Consequently, the state boasts the high- tors and technology centers, whose exist- est level of infrastructure within Germany ence can be pivotal for a start-up company. including the country’s densest railway As catalysts for regional infrastructure and ~345 other life science network and seven international airports. related companies economic development, there are approxi- Handling more than 130 million tons of mately 55 such centers and incubators in goods in 2017 per year, Duisburg is the the immediate vicinity of universities and world’s largest inland port.5 With over 100 basic research institutions in NRW. 19 % of all annual international trade fairs NRW has Fig. 1: Life Science Company Landscape in German start-ups are based in NRW, the high- the largest trade fair venue of the world. North Rhine-Westphalia est rate of all German states.6 They perform

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12 BIO.NRW technology transfer all the way from mind to market. At the time of the editorial deadline IDEA MARKET of this brochure, a total of 126 biotech and life science related companies were incubated Branch Product/Service by 23 of these technology centers.7 You will find the respective locations of the centers Energy Raw Materials / Fuels and the number of biotech companies each (functionalized) Foods / Fertilizer / Crops / of them hosts on the map on page 24. The Agriculture services these start-up centers provide Plant Protection include renting of affordable laboratory and Proteins / Peptides / Chemicals through Biotech Chemical Industry office space, mediating business contacts, Processes (Enzymes, MO) / Molecular Electronics consulting on funding opportunities, and Basic / fundamental / Pre-requisite for applied Basic Research advising on either founding or relocating reserach and development a firm. Business plan competitions are of- Drug Delivery / (Companion) Diagnostics / fered as an additional chance for support. Healthcare / Pharma Medical Devices / Therapeutics One technology park that deserves to find BIOTECHNOLOGY special mention here is BioCampus Cologne, Facilities / Infrastructure Transport ⁄ Laboratory supply / Materials one of the largest of its type in Germany. It houses more than 23,000 square meters of Engineering Nanotechnology Engineering Laboratory Information Systems / Digital (Biomedical) - IT office and laboratory space, including state of Healthcare / Biological Computing / Databases the art S1- and S2 labs, and industrial production facilities on a site totaling more than 25 hectares. Company founders, young entre- Fig. 2: Biotechnology is a strongly linked industry preneurs and scientists all profit from NRW’s highly-networked biotechnology scene. Applied Sciences (75; 25 with life science science and education and are pursuing their activity), Max Planck Institutes (13; 6 with studies in NRW8, remarkably one third of all Academic Biotech Research life science activity), Fraunhofer Institutes STEM fields (Science, Technology, Engineer- (14; 5 with life science activity), Helmholtz ing and Mathematics) students are studying North Rhine-Westphalia is offering Germany’s Institutes (4; 3 with life science activity) and in NRW. University centers can be found in most comprehensive network of academic Leibniz Institutes (11; 6 with life science activ- Aachen, Bonn, Cologne, Düsseldorf, Mün- institutions consisting of internationally ity). 27,2 % of all German students are taking ster, Bochum, Essen, Dortmund, Bielefeld, renowned Universities and Universities of advantage of this excellent environment for and other cities in the state. In the area of

Percentage of NRW Annual turnover Total R&D expenditure (Mio. EUR) NRW * Germany ** relative to Germany Number of 1,000 5,573 25,927 21.5 employees 800 Turnover Mio 2,073 4,014 51.1 1,185 4 bn EUR R&D expenditure 366 1,185 30.9 600 Mio Biotechnology 108 647 16.7 400 active companies 366 * data according to BioDeutschland survey - NRW, ** data according to Ernst & Young GmbH - 48.6 % 51.4 % 0 BioDeutschland survey - Germany NRW Rest of Germany NRW Rest of Germany Fig. 3: Key biotechnology facts; NRW and Germany

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14 BIO.NRW biotechnology, specializations in cell biology, Table 1: Temporal Development Key Figures for the Biotechnology Industry of (bio-) medicine, biochemistry, genomics, pro- North Rhine-Westphalia teomics, metabolomics, molecular biology, systems and synthetic biology, analytics/ 2015 2016 2017 microsystems, bioinformatics and process Number of 4,229 4,963 5,573 engineering are all on offer. employees For over a decade, NRW has been the Turnover EUR 1.671 bn EUR 1.819 bn EUR 2.073 bn leading German region in stem cell research R&D and development with Münster, Bonn and EUR 330 m EUR 394 m EUR 366 m Cologne as hotspots. In the field of plant expenditure genetics, the Max-Planck-Institute for Plant based on company survey by BIO Deutschland e.V. Breeding Research, Cologne deserves to be called the “cradle of plant biotechnology” Additionally several world leading neurosci- covering 800.000 square meters, “Campus in Germany as the first plant transforma- ence institutes are located in close proxim- Melaten” of the RWTH Aachen University will tion technologies were developed here. It ity. In 2013 alone more than 193 million house up to 11 technology clusters, among is now tightly interacting with the Cluster euros were invested into the neuroscience them the “cluster biomedical technology” of Excellence on Plant Science (CEPLAS) research facilities of the DZNE (German and take up investments of 1 billion euros. that was founded in 2012 – an 32 million Center for Neurodegenerative Diseases) Cooperation of academia and indus - euros collaboration of several universities and the department of the university hospi- try are creating synergy effects, e.g. the and research institutes. In 2019, CEPLAS Forschungszentrum Jülich has a long- will receive a new grant of 56.8 million euros 6,1% standing cooperation with Siemens Medical for 7 years. Solutions to develop specialized instruments Recent examples from Cologne empha- and techniques for brain research. BIO. size the very dynamic development of NRW 22% NRW offers detailed information about the as a research location: in May 2013 the all 34,1% academic life science landscape in NRW in new research facilities of CECAD (Cluster its compendium “Spot on Biotechnology of Excellence-Cellular Stress Responses Science”. This brochure is composed in a in Aging-Associated Diseases) have been similar manner like “Spot on Biotechnology 37,8 % opened – an investment of 85 million euros. Business“ and presents a total of 227 profiles In 2019, the CECAD will also receive renewed of research institutes, centers and facilities funding over 7 years. In October 2013 the in NRW. Its second issue has been released Max-Planck Society opened the new facility in November 2016. of the Max-Planck Institute (MPI) for Biology below 10 10-19 20-49 of Ageing in immediate vicinity to the new more than 50 Biotech Business CECAD building on the university campus. They offer cutting edge infrastructure and Fig. 4: Size of Dedicated Biotechnology Biotechnology became one of the most technology, incl. laboratory and office space Companies (Number of Employees) dynamic business sectors over the past few for together more than 700 international sci- decades. Having such a complex industry it entists, staff and students. Directly next to tal Bonn. Along with the respective institutes is hard to find a simple value chain or to sepa- the MPI and CECAD the Center for Integrated of the Universities of Cologne and Bonn as rate it from other, more “static” industries. Oncology (CIO) is located. To obtain a fast well as their University Hospitals plus the Biotechnology routinely uses other technol- pipeline from basic research to final thera- DZNE in Bonn, Cologne has been developed ogies, e.g. Nanotechnology and Engineering, peutics the CIO is currently being expanded into a world-wide unique competence center to improve products. However, all colors of for 78 million euros. Here, newest research for ageing research. About one hour west biotechnology (green, red, white and blue) progress is directly implemented into indi- of Cologne, Europe’s most innovative tech- are linked to diverse other branches like vidual therapies for the patient’s well-being. nology campus is currently taking shape: the chemical industry (Figure 2, page 13).

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Putting the view on single services and prod- contrast to the business figures of the dedi- in Europe, seven are biotechnology active ucts makes it obvious, that looking only on cated biotech companies – as an example companies and three of these, namely Bayer, dedicated biotechnology companies reveals – the 2017 sales of Bayer AG and Evonik Henkel and Evonik, are based in NRW.12 an artificially reduced impact biotechnology Industries AG alone, both headquartered The business figures of the 128 NRW bio- has on the entire industry. For example a in NRW, are 35 billion euros and 14.4 billion technological active companies are set into recent report elucidated that the sum of euros, respectively. Even though only a part comparison with the 627 German biotech the turnover of the European bioeconomy of their turnover can be assigned to NRW companies. In NRW 5,574 people (of about industry, is more than 2.3 trillion euros (!) sites and not all products are generated 25,927 nationwide) – more than in any other and over 18.5 million people are employed involving biotech processes, the key busi- German federal state – were employed by in bio-based industries, underlying the ness sectors of both companies are based dedicated biotech companies in 2017 and importance of biotechnology on the whole on biotechnology. These two examples generated a turnover of approximately 2,07 economy.9 clearly demonstrate the enormous impact billion euros (Table 1, page 15). Nevertheless, it is crucial to have a uniform biotechnology has on the overall industry in According to the national company definition of the core biotech companies to NRW and Germany. survey by EY – that is also based on BIO monitor the development of the industry. According to the latest OECD Biotechno- Deutschland data – the NRW biotechnology This is especially true for start-ups which logical Statistics report (which – except for active companies generated about 51.6 % are the innovative center of the community. limited “indicator” updates – still is the latest of the German biotech annual turnover. 13 For this purpose BIO Deutschland e.V., the published detailed study in the field by the Thus, the biotech industry in NRW is – to a branch association of the German biotech OECD), North Rhine-Westphalia is Europe’s large extend – responsible for the economic industry and organizations, annually carries most innovative biotechnology region: It impact of the German biotech business as a out a statistical analysis of the German core generates more biotech PCT patent appli- whole. 366 million euros – a annual decrease biotech companies, allowing a more sophis- cations than any other European region. 10 by 7.1 % compared to 2016 (368 million ticated view of the biotechnology landscape The development of biotech innovations euros) – was reinvested into R&D projects. in Germany. It was carried out for the third from NRW has been constantly increasing: The development of this key business time in 2018. 4,121 biotech patents have been filed within figures underlines that the investments by The framework of the analysis is set by 4 years by NRW biotech companies and the dedicated biotech companies in NRW the OECD definition of a dedicated biotech research facilities of which 4,118 have been are persistent in essence and will advance company and biotech associated companies published.11 Of the top ten patent applicants the future market position of NRW biotech. (see page 74). Based on this definition, 108 Together, NRW biotech firms are placing the dedicated biotech companies were operat- highest investments for R&D of innovative ing in NRW in 2017. Their activities were 4,6% 4,6% products – nationwide. Overall, the propor- complemented by 20 other companies with 5,9% 17,1% tional expenditure, of biotech companies a biotechnological commitment, mostly based in NRW, for R&D, being at 17.7 % of the global players in the field of pharmaceuti- annual turnover is more than 6 times higher cals, chemicals or seed production. Since 21,1% than the mean of all businesses in Germany these companies are active in many diverse 44,1% (average of 2.87 %).14 areas, their biotech related business figures 2,6% The employee structure reflects the mixture cannot be calculated exactly and are not of companies based in NRW; 34.1 % of all com- included in the following statistics. 16,7 % panies have less than 10 employees, 37.8 % of all german biotech companies are located have less than 20 employees, 22 % have less in NRW (Table 2, page 21). Therapeutica Diagnostica than 50 employees. 6.1 % employ more than The real economic impact of biotechnol- Drug Delivery Non-specific services 50 people (Figure 4, page 15). ogy in NRW is therefore higher than these Bioinformatics Agrobiotechnology After financing rounds of 14.8 million euros statistics reveal. These companies listed Industrial biotechnology in 2016, financing rounds of biotech companies here are at the innovative core of biotech- decreased to 2 million euros in 2017 contri- nological research and development. In Fig. 5: Areas of activity buted by Grünenthal Group. At the end of

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2018, the investment volume recovered Indication Number of Products again to 15 million euros due to a financing round in Jennewein Biotechnologie GmbH.15 Neoplasms / cancer / oncology 34 Of course, the total amount of non-public Infectious and parasitic diseases 19 investments into biotech companies in NRW Diseases of the nervous system 15 was much higher than these numbers reveal. Diseases of the blood and blood-forming organs; immune disorders 8 In addition to the big community of business Symptoms, signs abnormal clinical and laboratory findings, not elsewhere classified 6 angels based in NRW, numerous (institutional) Skin and subcutaneous tissue 5 investors set up their business headquarter Musculoskeletal system and connective tissue 4 along the Rhine within the last years. These Respiratory 2 investors strongly foster young biotech com- Mental and behavioural disorders 2 panies. Investment activities into life science Cardiovascular 1 companies are also supported by the state, Digestive system 1 e.g. through our “BIO.NRW Business Angel Diseases of the eye 1 Zirkel” and our annually “Business Angel Endocrine, nutritional and metabolic diseases 1 Congress”. Injury, poisoning and certain other consequences of external causes 1 21,1 % of biotech companies in North Rhine- Other 1 Westphalia are active in multiple branches (Figure 5, page 17). These biotechnology Total 101 companies with “nonspecific business activities” include service providers and suppliers Fig. 6: Drug Development Pipeline by Indication for the industry. Germany’s two largest biotech companies with the highest numbers near Cologne. Since then, the company has The majority of dedicated NRW biotech of employees in Germany, QIAGEN GmbH expanded to more than 2,500 employees companies (63,8 %) are active in the field of and Miltenyi Biotec GmbH used to be listed worldwide who produce and market over health and medicine developing new drugs here.12 As Qiagen has developed into the field 14,000 products for the global biomedical or diagnostics within the pharmaceutical of medical applications, meanwhile the com- research community. It is remarkable that sector (Figure 5, page 17). At the time of pany is accounted as a dedicated biotech this success has been solely achieved by the editorial deadline of this brochure the company in the „health-medicine“sector in generic growth. dedicated biotech companies in the field of this survey. QIAGEN began as a spin-off from the Discovery University of Düsseldorf in 1984. Today, the n/a 11 25 company employs more than 4,800 experts at 29 sites worldwide, and has become the leading provider of sample technology and a top player in molecular diagnostics especially in cancer detection and prevention. Through a number of strategic moves QIA- Preclinical 40 GEN today is one of the leading companies On the Market in biomarker discovery and development 8 (i.e. companion diagnostics), which is the basis for the company’s redirection to the Phase III 4 health business. Phase II Based on the invention of a magnetic 7 Phase I 6 cell separation technology, Miltenyi Biotec was founded 1989 in Bergisch Gladbach Fig. 7: Drug Development Pipeline by Phase

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20 BIO.NRW health and medicine had developed a drug Table 2: Number of dedicated biotech companies pipeline of in total 101 products and product candidates, remaining mostly constant over NRW dedicated biotech Germany Business Year the last years. The detailed distribution by in- companies (active companies) dication lists as clear top one category “neo- 2007 53 496 plasms/cancer/oncology”, with 34 products 2008 61 501 in pipeline in 2017 (2017 - 32 products, 2009 68 531 Figure 6, page 19). This is followed by “infectious and parasitic diseases” that increased 2010 71 538 from 14 (2017) to 19 products in pipeline 2011 77 552 (2018). “Diseases of the nervous system” (15) 2012 84 565 increased by 5 compared to 2017 with 10, and “Diseases of the blood and blood-forming 2013 87 570 organs; immune disorders” are on the fourth 2014 89 579 place with 8 products (2 in 2017). 2015 95 590 The pipeline includes 17 therapeutics (13 in 2016 109 623 2017, Figure 7, page 19) in the clinical phases I to III (17.2 %).15 The majority of products (38.4 2017 108 647 – 49.5 %) are preclinical drug candidates. 2007 - 2014 based on survey by BIOCOM; 2015 - 2017 based on survey by BioDeutschland The overall number of products in development pipeline significantly increased com- and universities, as well as other stakehold- In NRW, CLIB is coordinating the regional pared to 2017 with 99 products (+ 32.9 %). ers active in biotechnology and bioeconomy innovation network (RIN) “Stoffströme”, The underlying classification refers to com- as a whole. The cluster comprises over which seeks to improve the exploitation panies that develop enzymes, biomaterials 100 members with a share of about 25 % of biomass, wastes, and side streams in or bioprocesses, which can be applied to international members. The overall goal of the region. This action is funded by NRW’s facilitate or enable large-scale production CLIB is to network stakeholders along and Ministry of Culture and Science (MKW). in the chemical industry. The NRW-based across value chains and to identify new Another NRW-based project is dedicated companies Henkel and Evonik have been pio- opportunities for innovation, projects, and to improve identification and production neering industrial biotechnology worldwide business. Through this, the cluster develops of high performance ingredients (HiPerIn) and are still its pacesetters. cross-sectoral biotechnological solutions for markets like adhesives, cosmetics, or for sustainable processes and products. food and feed. This action is funded by the Competence Clusters Pertinent project areas are identified by the Ministry of Economic Affairs, Innovation, CLIB team in conjunction with members in Digitalization and Energy of the State of Besides the large number of biotech com- an iterative process. North Rhine-Westphalia. panies, which have specialized in enabling CLIB is a non-profit association, with its Besides this, CLIB established together technologies, two main fields of activity members shaping the cluster’s interests and with partners in Germany, Flanders, and characterize the biotechnology landscape activities. The cluster coordinates several as- the Netherlands, the BioInnovation Growth in North Rhine-Westphalia: Industrial sociated programmes which cover different mega-Cluster (BIG-Cluster), which aims at Biotechnology and Pharmaceutical Bio - aspects of bioeconomy, and invites members developing novel cross-border value chains technology. to become involved. To this end, CLIB organ- on the topics lignocellulose, C1 gases, ises a number of events throughout the year: aviation fuels and cross-border education. Industrial Biotechnology – CLIB2021 the annual CLIB international conference In 2018, three new projects under the BIG- (CIC), forum events, topic-specific work- Cluster umbrella started. In ALIGN the con- CLIB (Cluster Industrial Biotechnology) is shops, dedicated small partnering meetings sortium aims at producing new high-value an international open innovation cluster of and visits to partners, sites or meetings in aromatics based on lignocellulose. Within large companies, SMEs, academic institutes Germany and abroad. the project BioCOnversion, the partners

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22 BIO.NRW will develop a biotechnological process for heartland of Germany’s pharmaceutical healthcare, the pharmaceutical industry and

CO/CO2 gas conversion. In CROSSBEE a industry with an exceptional standard in bio- red biotechnology in the state. cross-border bioeconomy education will technological and medical education. This ad- be established. All three projects are co- vantage, combined with the enormous market From Mind to Market ordinated by CLIB and are funded by the potential of biopharmaceuticals, gave reason German Federal Ministry of Education and for BIO.NRW’s strategic initiative in the field This chapter provides an overview of 95 of Research (BMBF) with 3 million euros over of red biotechnology called BIO.NRW.red. Its the dedicated and 12 of the other biotechno- a period of 3 years. starting point was the competition “Bio.NRW” logical-active companies from North Rhine- in 2009, a call for projects announced by Westphalia as classified following the OECD Pharmaceutical Biotechnology – NRW’s Ministry of Innovation, Science and guidelines (page 74). For convenience, the BIO.NRW.red Research (MIWF; renamed to MKW, Ministry of companies are grouped in six areas according Culture and Science of the State North Rhine- to their main business: In the last decades, major milestones in Westphalia in 2017) to support the formation medicine and healthcare have been achieved of consortia between academia and biotech Non-specific Services through pharmaceutical (“red”) biotechnol- companies. The focal areas of the successful Health and Medicine ogy, namely in the development of drugs, projects were: development of drugs (bio- (including Animal Health) vaccines and diagnostics. In 2017, 383 logicals and small molecules), generation of Industrial Biotechnology medical biotech companies were registered new methods in diagnostics, establishment of Agri/Agrobiotechnology in Germany, 118 of them already have biop- biomarkers and introduction of new biophar- Bioinformatics harmaceutical products in the market and / maceutical technology platforms – especially Other biotechnologically companies or have their own product pipeline. The re- based on cell cultures technology. maining 265 companies contribute to drug Since 2009 the MIWF / MKW announced For a more comprehensive directory that development for example by their technol- several further calls for proposals in the field includes all life science and life science ogy platforms. For many years most of the of red biotechnology like “PerMed.NRW” related companies in NRW, please visit our German biotech companies are active in the (by the end of 2010), focused on personal- company database at www.bio.nrw.de/en/ field of red biotechnology.16 Likewise, in NRW ised medicine and “Translational Stem Cell company_database. the key task of most of the dedicated biotech Research” (finished in June 2014). These BIO.NRW invites you to discover North companies is developing drugs or diagnostics activities continue to effectively boost the Rhine-Westphalia‘s biotechnology com- or finding new ways for drug delivery. BIO.NRW.red initiative. munity! Taking a closer look at the overall German By the end of 2014 a new series of competi- medical biotechnology area, including bio- tions were published by NRW’s state govern- pharmaceuticals, the year 2017 has been a ment, focussing on translational research in good one. The sales of biopharmaceuticals in eight so-called “main markets” (NRW Leit- Germany increased by 10.3 % in 2017 relative marktwettbewerbe), adopting a “two-rounds to 2016 and reached a volume of about 10.2 funding model”. Each round includes two calls billion euros, which corresponds to 26.0 % of for proposals. The result of three calls (the two the total pharmaceutical market in 2017. 23 of the first and one of the second rounds) in (13 new biopharmaceutical compounds, 10 the main market “LifeSciences” is published biosimilars) out of 45 newly approved drugs on www.leitmarktagentur.nrw/leitmarktwett- were biopharmaceuticals in 2017. This cor- bewerbe/lifesciences. Until now 31 innovative responds to 51 % of all new approvals – more research projects have been funded with an than ever before.16 And the biopharmaceutical overall amount of 57.3 million euros.17 The pipeline is still filled, 639 compounds are in deadline of the last call was November 7 th clinical development (phase I-III), 25.0 % of 2018. Members of all the new consortia will the entire phase III pipelines are biosimilars.16 expand the sustainable BIO.NRW.red network For more than a century, NRW has been the that connects major contributors to medicine,

23 BIO.NRW

Biotechnology Map of North Rhine-Westphalia Life Science Technology Parks and Incubators

The Netherlands

Q Gronau Weser

Q Bielefeld 4 1 6 Q Münster Q Ascheberg Q Rheda-Wiedenbrueck 1 Ems Rhine

Lippe

Q Bönen Dortmund 9 Essen 5 1 1 Q BochumQ Q Q 1 10 Essen 2 Q Ruhr Q Nettetal Witten 4 Q Witten Q Wuppertal Düsseldorf Q 9 Q Hilden Q Monheim 8 Q Langenfeld 1 Q Bergisch-Gladbach 7 10 25 Baesweiler 1 Q Köln Q Jülich 4 Herzogenrath 4 Q Q Troisdorf Q Rhine 2Q 8 Aachen Q Bonn2 Rheinbach Q Belgium Germany

24 BIO.NRW

Name City Companies* Homepage

Zentrum für Bio-Medizintechnik (ZBMT) 8 1 Aachen www.agit.de TZA -Technologiezentrum am Europaplatz Aachen 2

2 INCA Technologiezentrum GmbH Ascheberg 1 www.inca-technologiezentrum.de

3 its-Internationales Technologie- und Service-Center Baesweiler Baesweiler 7 www.its-center.de Bergisch- 4 Technologiepark Bergisch-Gladbach 1 www.tbg.de Gladbach 5 Technologiezentrum Bielefeld Bielefeld 1 www.technologiezentrum-bielefeld.de

6 BMZ - BioMedizinZentrum Bochum Bochum 5 www.bmz-bochum.de

7 TZR - Technologiezentrum Ruhr Bochum 1 www.chip-tzr.de

8 Bio-Security Bönen 9 www.bio-security.de

9 BMZ - BioMedizinZentrum Dortmund Dortmund 10 www.bmz-do.de

10 Zentrum für Mikro- und Nanotechnologie Dortmund 1 www.mst-factory.de

11 LSC - Life Science Center Düsseldorf Düsseldorf 9 www.lsc-dus.de

12 ETEC - Essener Technologie- und Entwicklungs-Centrum GmbH Essen 1 www.etec.de

13 TPH - Technologie Park Herzogenrath Herzogenrath 4 www.tph.de

14 Technologiezentrum Jülich Jülich 1 www.tz-juelich.de

15 BioCampus Cologne Grundbesitz GmbH & Co. KG Köln 25 www.biocampuscologne.de

16 RTZ - Rechtsrheinisches Technologie- und Gründerzentrum Köln Köln 10 www.rtz.de

17 TechnologiePark Köln Köln 4 www.tpk.de

18 Creative Campus Monheim Monheim 8 www.cc-monheim.de www.technologiefoerderung- 19 Technologieförderung Münster GmbH Münster 4 muenster.de 20 CeNTech - Center for Nanotechnology Münster 6 www.centech.de

21 Gründer- und Technologiezentrum Rheinbach Rheinbach 2 www.wfeg-rheinbach.de

22 Forschungs- und Entwicklungs-Zentrum Witten GmbH Witten 2 www.fez.de

23 Technologiezentrum Wuppertal W-tec GmbH Wuppertal 4 www.w-tec.de

Total: 23 126

* Life Science Companies

25 BIO.NRW

Biotechnology Map of North Rhine-Westphalia Dedicated and other biotechnologically active companies

The Netherlands Q Gronau Weser Q Greven Q Bad Salzuflen Q Münster Bielefeld Q Q Leopoldshöhe

Q Ascheberg Ems Q Rhine Bocholt Q Bönen Lippe Q Marl Q Lippstadt

Q Q Dortmund Duisburg Q Q Bochum Essen Q Witten Ruhr Q Q Wuppertal Nettetal Düsseldorf Q Q Erkrath Neuss Q MonheimQ Hilden Mönchengladbach Q Q Q Langenfeld Q Leverkusen Q Bergisch Gladbach Baesweiler Q Q Köln Q Q Jülich Herzogenrath Niederkassel Q Q Troisdorf Q Würselen Q Q Düren St. Augustin Q Aachen Rhine Q Bonn

Belgium Germany

26 BIO.NRW

Dedicated companies1, 3 miacom diagnostics GmbH Düsseldorf p. 46 Miltenyi Biotec GmbH Bergisch Gladbach p. 33 Adhesys Medical GmbH Aachen p. 39 MLM Medical Labs GmbH Mönchengladbach p. 47 Affectis Pharmaceuticals AG Dortmund p. 39 Morphoplant GmbH Bochum p. 47 Agrojector UG Köln p. 59 multiBIND biotec GmbH Köln p. 55 AgroProtect GmbH Aachen p. 59 MykoMax GmbH Wuppertal p. 60 AiCuris Anti-infective Cures GmbH Wuppertal p. 39 Myriad International GmbH Köln Algiax Pharmaceuticals GmbH Erkrath p. 40 Ncardia AG Köln p. 47 aquila biolabs GmbH Baesweiler p. 29 NEO New Oncology GmbH Köln p. 48 arrows biomedical Deutschland GmbH Münster p. 40 NeraCare GmbH Bönen ARTES Biotechnology GmbH Langenfeld p. 29 Neuway Pharma GmbH Bonn p. 48 Attyloid GmbH Düsseldorf p. 40 NIPPON Genetics EUROPE GmbH Düren p. 34 Autodisplay Biotech GmbH Düsseldorf p. 53 Noscendo GmbH Duisburg p. 63 AYOXXA Biosystems GmbH Köln p. 29 Numaferm GmbH Düsseldorf p. 34 BBT Biotech GmbH Baesweiler p. 30 PAIA Biotech GmbH Köln p. 34 beniag GmbH Jülich p. 30 PAION AG Aachen p. 48 Bibitec GmbH Bielefeld p. 30 PerkinElmer chemagen Technologie GmbH Baesweiler p. 35 BioCheck GmbH Münster p. 41 PharmedArtis GmbH Aachen BioEcho UG Dormagen p. 41 Phytowelt Green Technologies GmbH Nettetal p. 60 Biofrontera AG Leverkusen p. 41 PL BioScience GmbH Aachen p. 35 Bio-Mar GbR Düsseldorf PlasmidFactory GmbH & Co. KG Bielefeld p. 35 BioSolveIT GmbH Sankt Augustin p. 63 Protagen AG Dortmund p. 49 bitop AG Witten p. 53 Protagen Protein Services GmbH Dortmund p. 36 Black Drop Biodrucker GmbH Aachen p. 31 QIAGEN GmbH Hilden p. 49 BSV Bioscience GmbH Baesweiler p. 53 Qithera GmbH Düsseldorf p. 49 Carpegen GmbH Münster p. 42 QLAYM GmbH Düsseldorf p. 64 CellAct Pharma GmbH Dortmund p. 42 RheinCell Therapeutics GmbH Düsseldorf p. 50 CellSystems Biotechnologie Vertrieb GmbH Troisdorf p. 31 Ridom GmbH Münster p. 64 CEVEC Pharmaceuticals GmbH Köln p. 42 Saaten-Union Biotec GmbH Leopoldshöhe p. 60 Chembiotech Münster SanguiBioTech GmbH Witten Chimera Biotec GmbH Dortmund p. 31 Senzyme GmbH Troisdorf p. 55 Cilian AG Münster p. 43 SeSaM-Biotech GmbH Aachen p. 56 CIRES Cell & Immune Dortmund p. 43 Soluventis GmbH Bochum p. 50 Colbourne Pharmaceuticals GmbH Niederkassel Squarix GmbH Marl p. 36 Creative Therapeutics GmbH Wuppertal p. 43 Syntab Therapeutics GmbH Würselen p. 50 Cube Biotech GmbH Monheim p. 32 Taconic Biosciences GmbH Köln Cygenia GmbH Aachen p. 44 Transimmune AG Düsseldorf p. 51 Cysal GmbH Münster p. 54 Vivo Science GmbH Gronau p. 36 Deutsche Saatveredelung AG Lippstadt p. 59 W42 Industrial Biotechnology GmbH Dortmund p. 56 Dynavax GmbH Düsseldorf XanTec bioanalytics GmbH Düsseldorf p. 37 evoxx technologies GmbH Monheim am Rhein p. 54 Xell AG Bielefeld p. 37 GEN-IAL GmbH Troisdorf p. 32 IIT Biotech GmbH Bielefeld p. 63 Other biotechnologically active companies2, 3 IMAX Discovery GmbH Dortmund p. 54 ImmunoQure AG Düsseldorf p. 44 Bayer AG Leverkusen p. 67 InfanDx AG Köln p. 44 Evonik Industries AG Essen p. 67 Informium AG Bergisch Gladbach German Seed Alliance GmbH Köln p. 67 Isoloid GmbH Düsseldorf p. 32 Grünenthal GmbH Aachen p. 68 Lead Discovery Center GmbH Dortmund p. 45 Henkel AG & Co. KGaA Düsseldorf p. 68 Lenio Biotech GmbH Bocholt p. 33 Janssen-Cilag GmbH Neuss p. 68 Life & Brain GmbH Bonn p. 45 Kyowa Hakko Europe GmbH Düsseldorf Lonza Cologne GmbH Köln p. 33 PHARMA WALDHOF GmbH Düsseldorf p. 69 m2p-labs GmbH Baesweiler p. 55 Syngenta Seeds GmbH Bad Salzuflen p. 69 Mares Ltd. Greven p. 45 UCB Pharma GmbH Monheim p. 69 Matricel GmbH Herzogenrath p. 46 W. von Borries-Eckendorf GmbH & Co.KG Leopoldshöhe p. 70 Melema Pharma GmbH Köln p. 46 WeissBioTech GmbH Aschberg 1 List of dedicated biotechnology companies in the fiscal year 2017 1 2 OECD Definition page 74 3 including company sites in NRW that are not headquarters and are therefore not accounted as NRW-based companies in the annual study by “BIO Deutschland e.V.” 27 Non-specific Services

28 BIO.NRW non-specific services

System) is the first easy-to-use and fully Name aquila biolabs GmbH automated solution for the feeding of liq- uids into shake flasks. aquila biolabs is a German company providing innovative technologies for Address Arnold-Sommerfeld-Ring 2 shake flask and bioreactor fermentations. Postal Code/City 52499 Baesweiler Currently, the company offers two main products: CGQ and LIS. E-Mail [email protected] The Cell Growth Quantifier (CGQ) of- Internet www.aquila-biolabs.de fers automated and non-invasive biomass monitoring for various cultivations vessels Employees 10 such as shake flasks, serum bottles or Founded (year) 2014 glass bioreactors. LIS (Liquid Injection

mendation, international registration, EMA Name ARTES resp. FDA approval and GRAS certification Biotechnology GmbH are achieved in international collaborations. Expression platforms include high yield Address Elisabeth-Selbert-Str. 9 yeasts and E. coli system for efficient pro- Postal Code/City 40764 Langenfeld ARTES Biotechnology is an independent tein production. Our unique chimeric virus technology provider for the pharmaceuti- like particle (VLP) platform METAVAX® is Fon +49 2173 27587-0 cal industry. Our business focus is on: best suited for the development of highly Fax +49 2173 27587-77 • vaccine development (VLP technology) immunogenic vaccines in human and ani- E-Mail [email protected] • process development of biopharma- mal health. Internet www.artes- ceuticals Our proprietary technologies ensure biotechnology.com • transfer of biosimilar processes freedom-to-operate and reliable, competi- Employees 22 Our technologies have resulted in innovative tive production of innovative targets mar- Founded (year) 2002 products marketed worldwide. WHO recom- keted worldwide.

support of basic biology and across drug Name AYOXXA Biosystems GmbH development. With its advantages in terms of quality, flexibility, robustness and efficiency, LUNARIS™ enables fully scal- Address Nattermannallee 1 able quantitative validation of biomarkers Postal Code/City 50829 Köln in minute amounts of biological samples. AYOXXA Biosystems GmbH is an inter- AYOXXA is commercializing a growing Fon +49 221 222529-0 national life science company based in portfolio of standardized ready-to-use Fax +49 221 222529-11 Cologne. With LUNARIS™, its proprietary biomarker analysis assays, with a focus on E-Mail [email protected] innovative beads-on-a-chip multiplexing the biology of inflammation and immune Internet www.ayoxxa.com platform for advanced protein analysis, response. the Company is paving the way for trans- Employees 35 lating knowledge generated in a laboratory Founded (year) 2010 environment through clinical studies in

29 non-specific services BIO.NRW

rators, filtration systems, chromatography Name BBT Biotech GmbH and freeze dryers. On the basis of individual needs BBT Biotech GmbH also offers active Address Arnold-Sommerfeld-Ring 28 pharmaceutical ingredients like thrombo- Postal Code/City 52499 Baesweiler lytics (streptokinase, urokinase), fertility hormones (HCG, HMG, FSH), inhibitors Fon +49 2401 93310-0 BBT Biotech GmbH produces freeze-dried (Aprotinin, UTI) and others (Hyaluronidase, Fax +49 2401 93310-90 viable bacteria (probiotics like lactobacilli, Corticotrophin). E-Mail [email protected] bifidobacteria, yeasts) and metabolites not Internet www.bbt-biotech.de only in bulk but also in finished dosage forms to the pharmaceutical and health- Employees 30 food industry. Founded (year) 1999 The fermenter capacity is up to 18.000 l. The downstream process is based on sepa-

aggregate with extremely high efficiency Name beniag GmbH within a few minutes. The unique transfer Address Huthmacherstrasse 20 mechanism allows manipulation of basi- Postal Code/City 52428 Jülich cally every mammalian cell type and incor- porates molecules directly into the cytosol, Fon +49 2461 616734 to guarantee their immediate bioactivity. +49 15780393499 beniag is a biotechnology company pro- beniag focusses on production and de- Fax +49 2461 613907 viding unique and highly efficient solutions velopment of customer oriented solutions E-Mail [email protected] to incorporate molecules into living cells with cooperation partners distributing the Internet www.beniag.com and tissue in vitro. Based on membrane product line “Fuse-It” worldwide. fusion as a completely novel and patented Employees < 10 transfer mechanism, beniag liposomes of- Founded (year) 2013 fer an outstanding opportunity for customers to incorporate any type of molecule or

and market production. Our value added Name BIBITEC GmbH services also include pharmaceutical development, ICH conform stability and viral safety studies. Address Universitätsstr. 25 BIBITEC Gesellschaft für Prozessent- Our project manager is your primary Postal Code/City 33615 Bielefeld wicklung mbH, a 100 % subsidiary of contact and is responsible for steering Nordmark Arzneimittel GmbH, is offering the entire process. With our customized Fon +49 521 106-6326 an all-in-one solution for mammalian cell project support BIBITEC is the partner of Fax +49 521 106-156233 culture technology. choice for biotech companies with indi- Internet www.bibitec.de Together with qualified partners, BIBITEC vidual needs. is able to cover the entire value chain from Employees 12 cell line and process development, analy- Founded (year) 2001 tics, GMP production of API and finished drug product up to regulatory affairs

30 BIO.NRW non-specific services

analogues, such as skin, liver, or heart Name Black Drop Biodrucker muscle patches offer an ideal platform for GmbH drug and toxicity screening. In the future bioprinted tissue implants could be used Address Gasborn 41 to maintain, restore, or substitute the Postal Code/City 52062 Aachen function of damaged tissues. As experts in 3D-bioprinting we provide our clients Fon +49 173 2618 104 with outstanding bioprinting hard- and Black Drop Biodrucker GmbH is a lead- software, highly biofunctional bioinks, and E-Mail [email protected] ing bioprinting company focused on bioprinted in-vitro models. Internet www.thebioprinting.com 3D-printing of living cells. Bioprinting is Besides our compact 3D-bioprinter a biomedical key technology that has the series, Black Drop SuperFill, we construct Employees 3 potential to improve medical patient treat- individualized bioprinting systems and Founded (year) 2017 ment in multiple ways. Bioprinted tissue develop tailored organ models.

In 2010, we opened our new clean room Name CellSystems laboratories to meet the growing demands Biotechnologie for various 3D tissue models and services. Vertrieb GmbH Today, our portfolio comprises a wide range of products for cell biology research Address Langeler Ring 5 Since its formation CellSystems ® has and in vitro toxicology studies. Postal Code/City 53842 Troisdorf been a reliable partner for the life science CellSystems is certified ISO 9001:2008. community. CellSystems offers highly so- Fon +49 2241 25515-0 phisticated research products, including Fax +49 2241 25515-30 EU validated 3D in vitro skin models for E-Mail [email protected] research and toxicology assays that were Internet www.cellsystems.de developed and are produced at our onsite laboratories. Additionally, CellSystems Founded (year) 1992 offers a wide range of contract services.

Corporate mission: Chimera Biotec is Name Chimera Biotec GmbH service provider for the development, validation and support of ultra sensitive and technically demanding immunoassays Address Emil-Figge-Str. 76a for quantifying large molecule targets in Postal Code/City 44227 Dortmund virtually any biological matrix. Chimera Description: Chimera Biotec is a GLP/GCP Biotec provides ultra sensitive GLP/GCP Fon +49 231 9742-840 certified bioanalytical Contract Research bioanalytical support for all phases of Fax +49 231 9742-844 Organization (CRO) specialized in ultra drug discovery and development. Chimera E-Mail [email protected] sensitive large-molecule bioanalysis on Biotec has the expertise and technical Internet www.chimera-biotec.com various technology platforms including capabilities to identify the ideal platform proprietary immuno-pcr (Imperacer ®) technology based on and run according Employees 20 technology. to your pharmacological and regulatory Founded (year) 2000 requirements.

31 non-specific services BIO.NRW

manufactured in house at high quality. The Name Cube Biotech GmbH product offering is complemented by reagents such as detergents, cell-free expres- Address Alfred-Nobel-Str. 10 sion lysates, nanodisc scaffold proteins, Postal Code/City 40789 Monheim The Cube Biotech team serves the biotech and patented membrane protein crystal- and pharmaceutical community with its lization plates. Some particularly relevant Fon +49 2173 99373-0 expertise on expression, purification, membrane proteins (GPCRs) are available Fax +49 2173 99373-99 stabilization and functional/structural as fully characterized preparations. E-Mail [email protected] characterization of proteins. Our projects Our services cover the expression, pu- Internet www.cube-biotech.com focus on the pharmaceutically relevant rification, stabilization and crystallization class of membrane proteins. Both products of soluble and membrane proteins for ap- Employees 14 and services are offered: A broad range of plications like cryo electron microscopy, Founded (year) 2012 products for the affinity chromatography antibody generation, crystallization and of proteins and stabilization of proteins are assays.

genetically modified organism (GMO), al- Name GEN-IAL GmbH lergenes, plant and animal-identity. The laboratory is accredited (DIN EN ISO/IEC Address Heuserweg 13-15 17025) and official cross checking labora- Postal Code/City 53842 Troisdorf tory. We are member in the German official GEN-IAL GmbH is a specialist laboratory working group for method development Fon +49 2241 252-2980 for DNA based food and feed analyses. for GMO detection and quantification. We Fax +49 2241 252-2989 GEN-IAL offers services and kits for GMO-, are a listed laboratory for the American E-Mail [email protected] allergene- and animal identity analyses NON-GMO- Project and the German VLOG Internet www.gen-ial.de as well as bacteria- and yeast detection (Verband Lebensmittel ohne Gentechnik and differentiation. We offer training in e.V.) for GMO-free labeling. Employees 10 PCR, contract research, several kits for New: Capturing of microorganism by Founded (year) 1998 DNA-extraction, PCR-kits for beer/wine polymer technology. spoilage bacteria and yeast, pathogenes,

due to harmful effects on the producing Name Isoloid GmbH organisms. Based on an innovative and proprietary Address Erkrather Str. 401 technology Isoloid GmbH overcame this Postal Code/City 40231 Düsseldorf challenge to offer high purity protein samples and labeled derivatives to your lab. Fon +49 211-81 15143 As a joint spin-off from Heinrich-Heine- High-purity samples of amyloid proteins University Düsseldorf and Forschungszen- E-Mail [email protected] and peptides are a key prerequisite for trum Jülich we build on a strong expertise Internet www.isoloid.de research and development on many severe and plenty years of experience in structural diseases, such as Alzheimer’s, Parkinson’s biology and biophysics to promote your Employees <10 and Diabetes mellitus type 2. However, research project. Founded (year) 2015 the biotechnological production of these proteins turned out to be challenging

32 BIO.NRW non-specific services

unprecedented performance and ease Name LenioBio GmbH of use. Our first product was launched in Octo- ber 2018; the cell-free protein expression Address Hemdener Weg 109 kit ALiCE®. This kit offers our customers Postal Code/City 46399 Bocholt LenioBio GmbH is a life sciences company higher protein yields in a single step than committed to the advancement of plat- any other cell free expression system cur- Fon +49 2871 2702888 forms for the development and expres- rently available. sion of complex proteins in biomedical, The ALiCE® platform has years of vali- E-Mail [email protected] industrial enzymes, agriculture and other dation as one of the cornerstone protein Internet www.leniobio.com relevant fields of application. expression technologies in a leading bio- Our aim is to establish a leadership tech company. Employees 8 position in the protein expression arena Founded (year) 2016 by offering cell free solutions that deliver

GmbH offers customized services, e.g. Name Lonza Cologne GmbH transfection services, proliferating cell services and cell modification services. Address Nattermannallee 1 The Lonza Cologne site develops, manu- Postal Code/City 50829 Köln factures and markets a comprehensive product portfolio of life-science research Fon +49 221 99199-190 tools around cultured cells, including non- viral gene transfer products for primary E-Mail [email protected] cells and hard-to-transfect cell lines. Internet www.lonza.com/research These products support scientists worldwide, enabling more efficient identi- Employees 110 fication of new targets for pharmaceuticals Founded (year) 1998 and therapies. Additionally Lonza Cologne

Over 30,000 scientific publications and Name Miltenyi Biotec GmbH the manufacture of more than 50,000 cell products for clinical use demonstrate the profound trust scientists and clinicians Address Friedrich-Ebert-Str. 68 have in MACS® Technology. Postal Code/City 51429 Bergisch Gladbach Miltenyi Biotec has been at the forefront Miltenyi Biotec develops products and ser- of immunology, stem cell biology, cancer Fon +49 2204 8306-0 vices that advance biomedical research and research, and neuroscience, as well as Fax +49 2204 85197 cell therapy. Our technologies inspire scien- the clinical areas of hematology, graft E-Mail [email protected] tists in basic and translational research, and engineering, and apheresis, for nearly 30 Internet www.miltenyibiotec.com support clinical applications. Our integrated years. More than 2,500 employees in 28 www.miltenyi.tv solutions enable sample preparation, cell countries are passionate about our cell and Employees > 2,500 separation, cell sorting, flow cytometry, cell gene therapy solutions. Founded (year) 1989 culture, and molecular analysis.

33 non-specific services BIO.NRW

NIPPON Genetics EUROPE GmbH, was Name NIPPON Genetics EUROPE GmbH founded in 2005 in Düren, NRW. We provide a wide variety of products to researchers Address Binsfelder Straße 77 around the world working at universities, Postal Code/City 52351 Düren research institutes, pharmaceutical and biotech companies and/or clinical laboratories. Fon +49 2421 55496-0 Our innovative products include gel docu- Fax +49 2421 55496-11 NIPPON Genetics is a Japanese Life-Tech mentation systems without UV-light, safe E-Mail [email protected] company, focused on the development of DNA-stains, cell freezing media, enzymes, Internet www.nippongenetics.eu cutting-edge products for molecular and cell lab plastics and many more! biology laboratories. We try to help research- Continuously growing and expanding our Employees 16 ers in making the bright future they envision portfolio and services, we want to provide Founded (year) 2005 a reality. In 1988, offices in Tokyo and Kyoto you with the best solution for your research were established. Our German subsidiary, requirements.

Our mission is to make peptides cheaper Name NUMAFERM GmbH and their production more eco-friendly in comparison to predominant chemical synthesis. With lower prices and a scalable Address Merowingerplatz 1a process, they also become accessible for Postal Code/City 40225 Düsseldorf non-pharmaceutical applications. NUMAFERM has developed an efficient and Founded in 2017, NUMAFERM is a venture Fon +49 211 9753290-0 effective biotechnology for the production capital-backed startup company headquar- E-Mail [email protected] of recombinant peptides. The drawbacks of tered in Düsseldorf, Germany. Internet www.numaferm.com available bioprocesses are overcome – for example proteolytic damage, aggregation Employees 12 and toxicity issues. Our technology serves Founded (year) 2017 as a reliable platform for peptides of any length.

cence detection. The assays are amenable Name PAIA Biotech GmbH to automation and run on fluorescence plate readers or microscopes. PAIA Biotech Address Gottfried Hagen Str. 60-62 focuses on products for screening applica- Postal Code/City 51105 Köln tions with limited sample volume and high throughput requirements, e.g. in early cell Fon +49 221 1686 2380 line development. PAIA Biotech GmbH offers assays for the In addition to off-the-shelf products PAIA E-Mail [email protected] rapid quantification of antibodies and pro- Biotech GmbH also offers custom assay Internet www.paiabio.com teins as well as glycosylation assays based development. on its proprietary technology. This technol- PAIA Biotech GmbH was founded in 2014 Employees 10 ogy uses proprietary 384-well microplates and is based at the RTZ in Cologne. Founded (year) 2014 that drastically simplify the workflow of bead-based immunoassay with fluores-

34 BIO.NRW non-specific services

RNA, and viral nucleic acids is based on the Name PerkinElmer chemagen use of proprietary M-PVA Magnetic Beads Technologie GmbH in combination with our high-performance instruments. Address Arnold-Sommerfeld-Ring 2 chemagen has developed numerous kits Postal Code/City 52499 Baesweiler for the isolation of nucleic acids from various sample materials such as blood, serum Fon +49 2401 805500 PerkinElmer chemagen Technologie GmbH or plasma, tissue, saliva, buccal swabs, Fax +49 2401 805519 is a key player in the field of automated amniotic fluid or stool samples. PerkinElmer E-Mail support.chemagen@ nucleic acid isolation with vast experience chemagen routinely develops customized perkinelmer.com in the field of DNA and RNA isolation for solutions addressing any specific require- Internet www.chemagen.com human genetics, HLA typing, blood banking, ments for DNA or RNA purification in close Employees >40 and pathogen detection. chemagen’s tech- coordination with clients. IVD versions of Founded (year) 1997 nology for the purification of genomic DNA, instruments and kits are available.

ucts, the team accelerates the translation of Name PL BioScience GmbH basic research into cell therapy. The start-up has a broad expertise con- BioScience cerning human Platelet Lysate as an alterna- WE DELIVER CELL SOLUTIONS tive to the ethical and safety-related doubt- Address Dennewartstraße 25-27 ful Fetal Bovine Serum. PL BioScience offers Postal Code/City 52068 Aachen diverse human Platelet Lysate-derived PL BioScience is an ambitious and dynamic products, e.g. the patent-protected 3D cell Fon +49 241 95719-100 life science start-up committed to cell ex- culture system PLMatrix. With its pathogen- Fax +49 241 95719-109 pansion in safe conditions. The company reduced products, the company provides E-Mail [email protected] has developed a portfolio of novel products a ‚new generation’ human Platelet Lysate Internet www.pl-bioscience.com and innovative technologies for human cell complying the highest safety guidelines for expansion in research and clinical applica- cell expansion in clinical and therapeutic Founded (year) 2015 tions. With its animal component-free prod- environments.

Germany. The company offers the pro - Name PlasmidFactory duction of plasmid and minicircle DNA in GmbH & Co. KG several quality grades: Research Grade and ccc Grade for research purposes and pre- Address Meisenstr. 96 clinical applications, High Quality Grade as Postal Code/City 33607 Bielefeld starting material for e.g. GMP production of RNA and viral vectors and GMP Grade Fon +49 521 2997-350 PlasmidFactory is the leading contract for clinical applications. Fax +49 521 2997-355 manufacturer of plasmid and minicircle Besides production of individual plas- E-Mail [email protected] DNA and the driving force in the develop- mids and minicircles, In Stock products Internet www.plasmidfactory.com ment of non-viral vectors for gene therapy that are deliverable immediately “off-the- and genetic vaccination. PlasmidFactory’s shelf”, e.g. reporter genes and AAV Helper Employees 18 research and development as well as the & Packaging vectors (pDG/ pDP family, Founded (year) 2000 complete service are located in Bielefeld, several serotypes) are also provided.

35 non-specific services BIO.NRW

characterization incl. modification of new Name Protagen Protein Services GmbH biological entities as well as biosimilar products. Comprehensive proteome studies and Address Otto-Hahn-Straße 15 differential protein display techniques are Postal Code/City 44227 Dortmund offered in addition for example to support Fon +49 231 9742-6100 Protagen Protein Services (PPS) is a world up and downstream process optimization of Fax +49 231 9742-6149 leading contract research organization with biotherapeutic production. PPS combines E-Mail contact@ProtagenProtein an large international customer base in the unique expertise in e.g. bioinformatics for Services.com field of Protein Analytics of biotherapeutics. protein mass spectrometry with a long track Internet www.ProtagenProtein With more than 20 years of market experi- record in protein chemistry and protein Services.com ence, PPS is able to offer a comprehensive, analytics. PPS provides you with the full Employees 70 GMP compliant spectrum of state of the range of services, from drug discovery and Founded (year) 1997 art analytical methods, ensure the highest development to release testing and regula- quality for the identification and structural tory compliance under ICH Q6B.

compounds for drug discovery industry and Name Squarix GmbH biotechnology reagents for life science applications com- prising antibodies, metabolic intermediates, Address Elbestr. 10 fluorescent dyes & probes and different af- Postal Code/City 45768 Marl finity matrices for proteins and cells. Moreover, Squarix is a custom producer Fon +49 2365 915-278 of polyclonal and monoclonal antibodies Fax +49 2365 915-254 Squarix GmbH is a privately-held primary for biomedical research and offers all type E-Mail [email protected] manufacturer of high purity Discovery of immunoanalytical services in the field of Internet www.squarix.de Chemicals and Immunoreagents. Since antibody technology. 1992, Squarix produces a broad product Employees 8 line of compounds that include innovative Founded (year) 1992 building blocks, reactive intermediates, natural products and derivatives, screening

from biotechnology. By merging with the in- Name vivo Science GmbH ternational Texcell Group with subsidiaries in Europe, Asia and North America, vivo Science Address Fabrikstr. 3 has expanded its portfolio and now acts as Postal Code/City 48599 Gronau a full service provider in the preclinical testing of biologics, pharmaceuticals, medical Fon +49 2562 8170-0 devices and chemicals as well as in GMP cell Fax +49 2562 8170-19 banking and viral safety. E-Mail [email protected] vivo Science is a GLP/GMP certified service In addition, vivo Science can include im- Internet www.vivoscience.de company for the pharmaceutical industry munological tests into standard toxicity (CRO) offering in vivo toxicology studies and studies. vivo Science will provide GLP/GMP Employees 17 is specialized in the testing of immunotoxi- compliant, validated study protocols and Founded (year) 2001 city (ICH-S8) and immunogenicity (ICH-S6) will assist you in setting up a customized of new drug candidates, especially if derived test program for your special requirements.

36 BIO.NRW non-specific services

devices. The hydrogel nanolayers exhibit Name XanTec an excellent haemo- and tissue compat- bioanalytics GmbH ibility and can be derivatized with growth or adhesion factors. Address Merowingerplatz 1a As complement to the biochip product Postal Code/City 40225 Düsseldorf line, XanTec offers SPR biosensors, which Nanobiotech company having more than allow highly sensitive real-time and label- Fon +49 211 9936-4744 20 years experience in surface deriva - free detection of biomolecular interactions Fax +49 211 9936-4746 tisation with bioinert and biofunctional at the molecular level. These instruments E-Mail [email protected] nanocoatings. Manufactures SPR or other can analyze binding constants / kinetics Internet www.xantec.com biosensor chips, coated slides for protein, and allow rapid concentration determina- cell and DNA based assays. Custom coat- tion, drug screening, epitope mapping, or Employees 12 ing of many materials, including glasses, adhesion studies with cells or viruses. Founded (year) 1997 metals and plastic, also for biomedical

analytical tools for in-depth characteriza- Name Xell AG tion of biological systems and pharmaceutical proteins, guaranteeing optimal solutions Address Waldweg 21 for our customers’ bioprocesses. Postal Code/City 33758 Schloss Holte- Based on our proprietary technology, Xell Stukenbrock has developed a wide range of customized as well as commercial high-performance Fon +49 5207 9597-200 Xell is an experienced partner for companies culture media, supplements and feeds for Fax +49 5207 9597-201 in the biotech and pharmaceutical industry specialized production cell lines includ- E-Mail [email protected] providing them with highly-efficient solu- ing CHO, hybridoma and HEK. Chemically Internet www.xell.ag tions in cell culture technology. With years of defined and free of animal components, industry experience, we bring our extensive our products meet or exceed all necessary Employees 32 expertise in high performance media and quality standards required for GMP manu- Founded (year) 2009 feed development, and apply our powerful facturing processes.

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Health and Medicine (including Animal Health)

38 BIO.NRW health and medicine

seal areas of leakage or re-attach tissue, or Name Adhesys Medical GmbH as a hemostat, to stop bleeding. The company was founded in 2013 in Aachen, Germany. In February 2014, the founders closed a 7-digit seed investment Address Pauwelsstraße 17 Adhesys Medical GmbH develops fully syn- round with S-UBG, KfW and a group of Postal Code/City 52074 Aachen thetic, biodegradable surgical adhesives. private investors. In April 2014 the team The first product FLIX® is designed for der- won the Rice Business Plan Competition in Fon +49 241 41250320 mal use, to close a great variety of topical Houston, Texas and expanded to the United wounds, and has received its CE-mark in States. In April 2017 the company was Internet www.adhesys-medical.com January 2018. Based on its unique poly- acquired by the pharmaceutical company urethane platform technology Adhesys Grünenthal and operates now as a wholly- Employees 15 develops further products for use inside owned subsidiary with offices in Aachen, Founded (year) 2013 the human body: either as an adhesive, to Germany and Boston, United States.

its programs at late discovery/early de- Name Affectis Pharmaceuticals AG velopment stage. The company is located in Dortmund, Germany, and is looking for academic and industrial collaborations for testing its frontrunner compound. Address Otto-Hahn-Str. 15 Postal Code/City 44227 Dortmund

Fon +49 231 97427000 Affectis is a pharmaceutical company Fax +49 231 97427069 developing novel proprietary drugs for E-Mail [email protected] the treatment of neurodegenerative and Internet www.affectis.com neuroinflammatory diseases based on pioneering findings in the field of P2X7 Founded (year) 2006 receptors. Affectis will partner or license

(letermovir), designed to inhibit the viral Name AiCuris Anti-infective terminase of human cytomegalovirus Cures GmbH (CMV), was licensed to MSD and is mar - keted in the US, Europe and Japan for the Address Friedrich-Ebert-Str. 475 prophylaxis of CMV infections in recipients Postal Code/City 42117 Wuppertal of bone marrow transplants. A Phase 3 AiCuris is a pharmaceutical company - trial in solid organ transplant recipients Fon +49 202 31763-0 focused on discovery, research and de- is ongoing. Fax +49 202 31763-1177 velopment of novel, resistance-breaking Further clinical programs include Priteli- E-Mail [email protected] antiviral and antibacterial agents for the vir, a helicase-primase inhibitor, developed Internet www.aicuris.com treatment of severe and potentially life- to treat recurrent labial and genital herpes threatening infectious diseases. infections, AIC499, a resistancebreaking- Employees 65 Since November 2017, the first product Gram(-) antibiotic and AIC649, an immune Founded (year) 2006 from AiCuris is on the market. PREVYMIS™ modulator targeted at Hepatitis B cure.

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male subjects exposed to AP-325) and shows Name Algiax Pharmaceuticals GmbH a good safety and tolerability profile in healthy volunteers after single and multiple dosing. Address Max-Planck-Str. 15a The human PK profile of AP-325 is compatible Postal Code/City 40699 Erkrath with once-a-day administration and fast onset Algiax Pharmaceuticals GmbH is a biotechnol- of action. A broad patent portfolio covering Fon +49 211 617851-15 ogy company that was established in April major commercial markets is solely owned by Fax +49 211 617851-50 2011. It is dedicated to the discovery and Algiax. The primary indication is neuropathic E-Mail [email protected] development of innovative products in the pain, the secondary indication is spinal cord Internet www.algiax.com field of nervous system disease with a strong injury for which Algiax has an orphan drug des- focus on neuropathic pain. The company’s ignation. Altogether, Algiax is well positioned Employees 6 lead compound AP-325 is currently in clinical to take advantage of the market opportunity Founded (year) 2011 development. The comprehensive Phase I not only in the field of neuropathic pain but program has been finalized (>100 male and fe- also in other unmet medical diseases.

microarrays(GenExpression, Array-CGH, Name arrows biomedical Deutschland GmbH ChIP on chip, DNA-Methylation-Microar- rays), PCR (RT-qPCR, Dpca) and bioinfor- Address Heisenbergstraße 11 matics. In the area of medical diagnostics, Postal Code/City 48149 Münster the portfolio includes routine analysis (testing for all clinical relevant biomarkers Fon +49 251 534064-00 arrows biomedical Deutschland carries and the complete range of blood analysis), Fax +49 251 534064-01 out contract research and clinical routine flow cytometry (NAVIOS), HPLC analysis, E-Mail [email protected] analyses, and also pursues its own R&D diagnostic microarrays, detection of freely Internet www.arrows-biomedical.com projects. The firm’s areas of focus are pri- circulating tumor cells, and chemosensitive marily in the fields of molecular oncology analysis. Furthermore, FISH analysis, general Employees 10 and neurodegenerative disease. Its port- microscopy with the Zeiss axio imager M 2 in Founded (year) 2005 folio of molecular analytics includes RNA/ combination with the MetaSystemsSoftware DNA. Services like RNA/DNA isolation, and Pyro-, NGS and Sanger sequencing.

attyloid offers its proprietary sFIDA plat- Name attyloid GmbH form technology featuring single particle sensitivity and a 4-log dynamic range of Address Elsa-Brändström-Str. 34 particle size and concentration. The ISO Postal Code/City 40595 Düsseldorf 9001-embedded sFIDA technology is fully attyloid GmbH was founded in 2018 and is automized and scalable. Fon +49 211 81 10377 located in Düsseldorf, Germany. Building on a strong scientific expertise in protein E-Mail [email protected] misfolding and aggregation, we focus our Internet www.attyloid.com business model on aggregate quantitation for development and QC of biologicals. Employees <10 Our mission is to revolutionize aggre- Founded (year) 2018 gate analytics to safeguard the biotechnological production chain.

40 BIO.NRW health and medicine

Biocheck GmbH offers a broad range of Name BioCheck GmbH different Polycheck® test panels which can be performed manually or fully automated matching with central Laboratory Information Systems (LIS). Evaluation and Address Vorbergweg 41 The Polycheck® Platform Technology calculation is done by picture scanning and Postal Code/City 48159 Münster was introduced by Biocheck GmbH as a by Biocheck Imaging Software. tool for medical in vitro diagnosis of al - Fon +49 251 2150-868 lergies and autoimmune diseases. The E-Mail [email protected] solid phase immunoassay technology is a Internet www.polycheck.de multiparameter test device for serological quantitative screening of disorder-specific Employees 25 immunoglobulins using monoclonal detec- Founded (year) 1999 tion antibodies.

a revolutionary single-step technology for Name BioEcho Life Sciences accelerated and simplified DNA and RNA GmbH purification processes. We apply this technology in the development of more convenient Liquid Biopsy Address Nattermannallee 1 procedures (isolation of circulating nucleic Postal Code/City 50829 Köln acids), faster NGS workflows, Point-of-Care diagnostics applications, and selected cus- Fon +49 0221 9988 97-0 Founded 2016 by a team of experts in tomization projects. E-Mail [email protected] genomic sample preparation (extraction Internet www.bioecho.de & clean-up of nucleic acids) BioEcho Life Sciences provides a new generation of kits Employees < 10 and reagents for genomic research and mo- Founded (year) 2016 lecular diagnostics. BioEcho has developed

development of photodynamic therapy of Name Biofrontera AG skin diseases its objective in a comparable manner. Address Hemmelrather Weg 201 Our most important products include a Postal Code/City 51377 Leverkusen prescription-only medication to treat non- Biofrontera is a biopharmaceutical com- melanoma skin cancer and its precursors Fon +49 214 87632-0 pany specializing in the development with photodynamic therapy. Our medication Fax +49 214 87632-90 and commercialization of dermatological has been marketed in the EU since 2012 and E-Mail [email protected] medications and medical cosmetics. By fo- in the USA since May 2016. Internet www.biofrontera.com cusing on photodynamic therapy, intensive Biofrontera AG is listed on the Frankfurt www.biofrontera-us.com knowledge of this therapy form has been Stock Exchange (Prime Standard), and, built up over the years and the company since February 2018, on the US NASDAQ Employees 149 has become an expert in this area. No other Capital Market. Founded (year) 1997 company worldwide has made the further

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based system that sets new standards in Name Carpegen GmbH microbiological periodontal diagnostics. A main objective of Carpegen’s research Address Mendelstr. 11 program is to develop and out-license Postal Code/City 48149 Münster POC/PCR systems for diverse applications in medical and non-medical markets. Fon +49 251 980-2320 Carpegen is a provider of high quality mo- Two joint R&D projects related to the devel- Fax +49 251 980-2321 lecular diagnostics. The company focuses opment of innovative antibiotic resistance E-Mail [email protected] on developing real-time PCR assays and diagnostics and water analytics are cur- Internet www.carpegen.de point-of-care (POC) diagnostics for the rently being pursued with financial support diagnosis of specific infections and the of the state of North Rhine-Westphalia and Employees 10 detection of genetic biomarkers. Car- the German Federal Ministry for Economic Founded (year) 2001 pegen has developed Carpegen ® Perio Affairs and Energy. Diagnostics, a powerful real-time PCR

CAP7.1 was acquired by MundiPharma for Name CellAct Pharma GmbH over >$250 million after a randomized, multi-center, phase II proof-of-concept Address Otto-Hahn-Str. 15 study in adults with end-stage biliary tract Postal Code/City 44227 Dortmund cancer in 2017.

Fon +49 231 9742-6350 Fax +49 231 9742-6355 CellAct’s small molecule compound, E-Mail [email protected] named CAP7.1, targets Topoisomerase II Internet www.cellact.eu and has shown efficacy and tolerability in various advanced cancer disease in phase Employees 7 I and II clinical studies. Founded (year) 2007 CAP7.1 received orphan drug status for biliary tract cancers from the EMA.

ing cell lines, including a stable, helper Name CEVEC Pharmaceuticals GmbH virus-free AAV production platform, which enable better scale-up and competitive Address Gottfried-Hagen-Str. 60-62 production costs when compared to adhe- Postal Code/City 51105 Köln rent cell culture systems. CEVEC is a center of expertise for the CAP-Go enables the production of pro- Fon +49 221 46020-800 production of biopharmaceuticals using teins previously out of reach representing Fax +49 221 46020-801 a unique human cell-based expression a significant proportion of the human E-Mail [email protected] system. proteome that is notoriously difficult to Internet www.cevec.com CAP-GT is a fully scalable manufacturing express in conventional cell lines such as platform for viral vector production, such CHO. as lentiviral, adenoviral and AAV vectors. Founded (year) 2003 CEVEC has successfully developed CAP- GT suspension cell-derived viral packag-

42 BIO.NRW health and medicine

Name Cilian AG

Address Johann-Krane-Weg 42 Postal Code/City 48149 Münster

Fon +49 251 6203-114 Fax +49 251 6203-116 Cilian AG is a biotechnology company de- E-Mail [email protected] veloping and marketing a novel expression Internet www.cilian.de system. The company uses a species of Ciliates, a eukaryotic single-cell organism, Employees 14 for the production of vaccines, monoclonal Founded (year) 2001 antibodies and therapeutic enzymes.

CIRES has further great experience in the Name CIRES cell + immune preclinical and clinical development and research services GmbH testing of vaccines and adjuvants. Address BioMedizinZentrum Bochum Universitätsstrasse 136 CIRES is experienced in all kinds of cell Postal Code/City 44799 Bochum culture techniques, ranging from genera- Fon +49 234 93696536 tion of hybridomas, culture of mammalian Fax +49 234 93696538 cells in general and the culture of lines of E-Mail [email protected] transgenic cells. This includes production Internet www.cires.de by Bioreactor technology, purification and labeling of monoclonal antibodies and Employees 3 development of ELISA tests. Founded (year) 2001

Currently there are no approved targeted Name Creative Therapeutics therapies of this type with such a multifac- GmbH eted mode of action. Recognizing the science-based chance Address Am Rohm 86 CreativeTherapeutics GmbH (CT) is a to realize the vision for a much more selec- Postal Code/City 42113 Wuppertal privately-held biotechnology company tive and well tolerated anticancer principle Fon +49 178 7272118 designing innovative, tailored cancer thera- CT was founded and started to realize its Fax +49 7690 7902 peutics causing genomic and metabolic mission. E-Mail zeiler@creative- instability resulting in epigenetic changes therapeutics.com leading to activation of the immunesystem. Internet www.creative-therapeutics. CT offers collaboration to advance its com lead asset CT913 through IND enabling Employees 2 studies to pave the way for Phase I in can- Founded (year) 2009 cer patients.

43 health and medicine BIO.NRW

mal stromal cells. In addition, we provide Name Cygenia GmbH biomarkers with clinical relevance and Address Am Alten Kalkwerk 14 to determine the state of aging in blood Postal Code/City 52078 Aachen samples of mice and men. We are experts in project design and Fon +49 241 53108060 advice you to find the best suitable bio- Fax +49 241 53108069 Cygenia is the first company to provide marker for your project. We address par- E-Mail [email protected] service on epigenetic biomarkers. Epige- ticularly scientists and clinicians. u.gerstenmaier@cygenia. netics is a new area of research that holds com great potential for cellular analysis. We Internet www.cygenia.com have established biomarkers to characterize cell culture with regard to replicative Founded (year) 2014 senescence, pluripotency, cellular com- position, or classification of mesenchy-

tibodies against key drug targets that are Name ImmunoQure AG involved in preventing a number of human diseases.

Address Königsallee 90 ImmunoQure AG is a young biotech Postal Code/City 40212 Düsseldorf company spearheading the research and development of human-derived antibodies E-Mail [email protected] (HD-MABs) for the treatment of human Internet www.immunoqure.com diseases. Through our unique access to rare pa- Founded (year) 2011 tient populations, we are able to identify patients harboring naturally optimized an-

6 h after delivery. No suitable diagnostic Name InfanDx AG exists today. Thus, ca. half of cases are not treated. Still, up to 15 unnecessary Address Balthasarstr. 18 treatments are applied to cure one patient. Postal Code/City 50670 Köln InfanDx develops the first test to be Develops first diagnostic test to detect applied immediately after birth. The im- Fon +49 221 3008 9783 perinatal asphyxia (PA, oxygen deficit dur- munology like format uses a small blood Fax +49 221 2851975 ing birth) and related braindamage. sample only. Technology origin is metabo- E-Mail [email protected] PA is very prevalent in childbirth world- lomics research. Internet www.infandx.com wide with 0.5-4 % of births affected. InfanDx seeks partnerships as. Typical outcome brain damage results in – pharma-partnering, („companion Employees < 10 e.g. cerebral palsy/spasticism, blindness diagnostic“, therapy monitoring) Founded (year) 2010 etc. Therapy is available and reimbursed – manufacturer of point-of-care device since 2010, but needs to be started within – marketing co-operations

44 BIO.NRW health and medicine

ducted in close collaboration with world- Name Lead Discovery Center class academic researchers from LDC’s GmbH broad network including the Max Planck Society, Helmholtz Association and numer- Address Otto-Hahn-Str. 15 ous universities. The LDC team consists of Postal Code/City 44227 Dortmund experts with solid industry experience in Bridging the gap between academic dis- Project Management as well as Screening, Fon +49 231 9742-7000 coveries and pharmaceutical development. Cellular Biology, Pharmacology, Medicinal Fax +49 231 9742-7039 Active in the field of drug discovery, LDC Chemistry and Therapeutic Antibody En- E-Mail [email protected] transforms promising early stage projects gineering. Internet www.lead-discovery.de into marketable assets providing industry LDC has formed alliances with AstraZen- with high-quality leads and biologics with eca, Bayer, Boehringer Ingelheim, Daiichi Employees 75 proof-of-concept in animals. These small Sankyo, Grünenthal, Johnson & Johnson, Founded (year) 2008 molecule drug discovery projects are con- Merck, Qurient, Roche and SOTIO.

The four business divisions Cellomics, Name Life & Brain GmbH Genomics, Electrophysiology Services and NeuroEconomics provide human stem cell-based cell culture systems and Address Sigmund-Freud-Str. 25 services for neurological disease model- Postal Code/City 53127 Bonn LIFE&BRAIN is a biomedical enterprise ling and compound development, genome serving as commercial hub of the Uni - and gene expression analysis, electro - Fon +49 228 6885-100 versity of Bonn Medical Center. Integrat- physiology services to characterize small Fax +49 228 6885-101 ing a unique set of expertise, we aim at molecules in target engagement, efficacy E-Mail [email protected] delivering future-oriented services and and potency in human and rodent models Internet www.lifeandbrain.com products for disease-related research and and neuroscientific methods for testing the development of novel therapies with a marketing effects. Employees 40 focus on neurological and neuropsychiat- Founded (year) 2002 ric diseases.

proprietary technologies and market Name Mares Ltd. these with partners. Our expertise derives from 20+ years of international experience in the EU, USA, and Asia. Address Münsterstrasse 87 At Mares Ltd, we serve two needs: We welcome inquiries from industry, Postal Code/City 48268 Greven 1) consulting/contracting in biolog - academia and government agencies. ics, advanced therapies and medical Fon +49 2571 9588 000 devices: aseptic processing, quality, Fax +49 2571 9588 003 facility design and execution, quality risk E-Mail [email protected] management Internet www.maresltd.eu 2) development and commerzialization of advanced technologies pertaining to Founded (year) 2007 manufacture of biologics: we develop

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engineering and regenerative medicine. Name Matricel GmbH The products serve different medical fields like ACI-Maix and Cartimaix for tissue engineering of articular cartilage and Address Kaiserstr. 100 other orthopedic applications and Remaix Postal Code/City 52134 Herzogenrath Matricel GmbH develops and produces as a dental membrane for guided bone innovative medical class III collagen im- regeneration. Fon +49 2407 5644-0 plants and biomatrices for applications in Matricel´s product Optimaix is dedicated E-Mail [email protected] medicine and biotechnology. for research in 3D cell culture. Matricel has Internet www.matricel.com Matricel´s proprietary technologies are a promising product pipeline in further the key to successfully produce biocom- medical fields like dermal and nerve regen- Employees 35 patible and biodegradable matrices in a eration with customized scaffolds. Founded (year) 2001 wide range of modifications suitable for the cultivation with human cells in tissue

ME-503 is in phase II of clinical develop- Name MELEMA Pharma GmbH ment. Subcutaneous injection leads to a substantial interaction of DC cells Address Nattermannallee 1 with cancer-fighting T cells. ME-503 has Postal Code/City 50829 Köln demonstrated efficacy in several phases I, I/II, and II trials. In melanoma stage IV Fon +49 221 2823 2520 Is a private clinical stage company founded ME-503 could improve the overall survival Fax +49 221 2823 2522 in September 2013. While legally head- of the patients. In this phase II trial, a pa- E-Mail h.lentzen@melemapharma. quartered of the predominantly virtually tient cohort could be defined, where the com company in Hamburg, the scientific base one-year survival rate was 62 % and the Internet www.melemapharma.de is in Cologne. median overall survival 14.6 months. We MELEMA is playing in one of the hottest are currently planning a larger controlled Founded (year) 2013 areas in oncology: Immunotherapy. Our phase II trial using a biomarker to predict most exciting development candidate clinical outcome.

less than 30 minutes directly from patient Name miacom diagnostics GmbH samples without need of tedious sample Address Merowingerplatz 1a preparation or DNA amplification. Postal Code/City 40225 Düsseldorf In addition to the world´s only molecular Miacom Diagnostics is specialized in de- diagnostic (MDx) test that identifies all rel- Fon +49 211 3015-5795 veloping next-level in vitro diagnostic tests evant pneumonia-related bacteria directly Fax +49 211 2989-143 for the identification of pathogens causing from sputum, miacom offers CE & FDA E-Mail info@miacom- acute systemic diseases. Miacom improves cleared multiplex test for sepsis. Our latest diagnostics.com critical patient care by providing rapid mo- innovation includes a fully automated rapid Internet www.miacom- lecular diagnostic tools designed for routine ID system that allows high-throughput MDx diagnostics.com use to promote more efficient antibiotic testing of several hundred samples per day. Employees 10 therapies and help healthcare organizations Since 2014 Fosun Diagnostics, the diagnos- Founded (year) 2006 reduce costs. Our proprietary Direct Multi- tic division of Shanghai Fosun Pharmaceuti- plex Imaging (DMI) assays deliver results in cal, is investor by miacom.

46 BIO.NRW health and medicine

USA, we offer seamless central laboratory Name MLM Medical Labs GmbH services for European and North American clinical sites. Our lab is on duty 365 days a year to en- Address Dohrweg 63 MLM Medical Labs is a central laboratory sure valid results with a quick turnaround Postal Code/City 41066 Mönchengladbach dedicated exclusively to clinical trials. We time. offer full laboratory services, including a Our lab services are complemented by a Fon +49 2161 4642102 whole range of analytics: standard safety superior IT infrastructure (e.g. mlm online® Fax +49 2161 4642190 profiles, such as blood counts, coagula- and MLM Sample Storage System ® and E-Mail [email protected] tion, urinalysis and clinical chemistry, and our own MLM Kit Building®) for customized Internet www.mlm-labs.com analyses of biomarkers, drug compounds, sampling kits. metabolites and molecular diagnostic Employees 70 parameters. With our strategic partner Founded (year) 1993 Cenetron Central Laboratories in Austin,

production, protein chemistry, molecular Name Morphoplant GmbH and cell biology, isotope protein labeling/ monitoring and optical biosensor technology are available to our experienced and Address Universitätsstr. 136 multidisciplinary R&D team. Morphoplant’s Postal Code/City 44799 Bochum proprietary technologies provide our customers with ultrahydrophilic and osteophilic Fon +49 234 7772870 long-term storable metal implant surfaces Fax +49 234 7772870-20 Morphoplant GmbH is a bio-/ medtec and solutions for biocoating of a variety of E-Mail [email protected] company headquartered at the BioMedizin- implant materials with recombinant growth Internet www.morphoplant.de Zentrum in Bochum and focused on the inte- factors (bone/ vascular). Our outstanding gration of biotech functionalities into medical expertise in surface functionalization, protein Employees 14 devices. Laboratories equipped with state-of- adsorption, kinetics monitoring and animal Founded (year) 2002 the-art technology for recombinant protein testing is also available for contract research.

In addition to its panel of hiPSC-derived Name Ncardia cardiac (Pluricyte®, Cor.4U®, vCor.4U®) and neural (CNS.4U®, Peri.4U® Astro.4U®) cells, Ncardia provides integrated safety and ef- Address Nattermannallee 1, ficacy services for pharmaceutical clients, Building S20 from disease modeling to high-throughput Postal Code/City 50829 Köln Ncardia is convinced that stem cell technol- drug screening. Ncardia is committed to the ogy will help give patients faster access to success of our clients and supports their Fon +49 0221 998818-0 better and safer medicines by improving the efforts with global scientific support and E-Mail [email protected] drug discovery and development process. custom solutions. Internet www.ncardia.com The company develops and produces highly Ncardia is based in Belgium, the Nether- predictive human cellular assay systems lands, Germany and the USA. The company Employees 60 for safety and efficacy screening of drug is privately held and established following the Founded (year) 2017 candidates. merger of Pluriomics and Axiogenesis.

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allows the pathology laboratories to per- Name NEO New Oncology GmbH form Hybrid capture NGS-based molecular diagnostics, thus facilitating them to obtain Address Gottfried-Hagen-Str. 20 reliable and clinically meaningful results Postal Code/City 51105 Köln from single clinical samples. NEO New Oncology GmbH is a molecular NEO New Oncology employs scientists in Fon +49 221 888 238-0 cancer diagnostics company enabling the field of cancer genomics, translational Fax +49 221 888 238-22 pathologists to identify individual tumor medicine, bioinformaticians and special- E-Mail [email protected] profiles and to analyze and interpret ists in diagnostic quality assurance. Since Internet www.newoncology.de therapy-relevant genomic changes. 2016, NEO New Oncology has been a wholly NEO New Oncology´s CE-IVD compliant owned subsidiary of Siemens Healthineers. Employees 50 technology platform NEOonsite combines Founded (year) 2012 reagents for sample preparation with a proprietary bioinformatics pipeline and

partner its CNS Drug Delivery Technology Name NEUWAY Pharma GmbH for application to proprietary compounds of pharmaceutical companies to exploit Address Ludwig-Erhard-Allee 2 its therapeutic use in the field of CNS Postal Code/City 53175 Bonn indications. The company is backed with venture Fon +49 228 522798-0 capital from renowned investors and a Fax +49 228 522798-99 strong board. E-Mail [email protected] NEUWAY Pharma GmbH, Bonn, Germany, Internet www.neuway-pharma.com is focusing on the preclinical and clinical development of innovative therapeutics for Employees 16 treatment of severe orphan brain diseases Founded (year) 2014 based on its proprietary CNS Drug Delivery Platform. The company also intends to

sedative/anesthetic drug candidate for Name Paion AG which PAION has completed the clinical development for use in procedural seda- Address Martinstr. 10-12 tion in the U.S. Outside the U.S., PAION is Postal Code/City 52062 Aachen currently focused on the development of remimazolam for general anesthesia. A full Fon +49 241 4453-152 PAION AG is a publicly listed specialty clinical development program for general Fax +49 241 4453-523 pharmaceutical company developing anesthesia has been completed in Japan. E-Mail [email protected] and aiming to commercialize innovative In the EU, PAION initiated a Phase III trial Internet www.paion.com drugs for out-patient and hospital-based in 2018. PAION’s vision is to become an sedation, anesthesia and critical care acknowledged “PAIONeer” in sedation Employees 8 services. PAION’s lead compound is and anesthesia. PAION is headquartered Founded (year) 2000 remimazolam, an intravenous, ultra-short- in Aachen (Germany) with an additional acting and controllable benzodiazepine site in Cambridge (UK).

48 BIO.NRW health and medicine

novel biomarkers using its proprietary Name Protagen AG immuno-profiling platform (SeroTag®), and stratification arrays based on biomarker panels (NavigAID) to screen patient serum We specialize in Pharma development specimens. Address Otto-Hahn-Str. 15 services and novel companion diagnos- We enable: Better disease activity as- Postal Code/City 44227 Dortmund tics, in the field of immuno-oncology and sessment, Improved response prediction, autoimmune disease. Via co-development Patient monitoring and Early detection of Fon +49 231 9742-6301 projects with Pharma and Biotech compa- immune-related adverse events (irAEs). E-Mail [email protected] nies, Protagen enables effective, targeted To find out how Protagen can support Internet www.protagen.com immuno-therapeutic development for your therapeutic development project to improved patient care. enable better response prediction, patient Employees 17 Protagen is at the forefront of im - monitoring and early detection of adverse Founded (year) 1997 muno-profiling and the discovery of events contact us now.

say technologies make these biomolecules Name QIAGEN GmbH visible and ready for analysis. Bioinformat- ics software and knowledge bases interpret data to report relevant, actionable insights. Address Qiagen Str. 1 Automation solutions tie these together Postal Code/City 40724 Hilden in seamless and cost-effective workflows. QIAGEN provides solutions to more than Fon +49 2103 29-0 QIAGEN is the leading global provider of 500,000 customers around the world in Fax +49 2103 29-22000 Sample to Insight solutions that enable Molecular Diagnostics (human healthcare), E-Mail [email protected] customers to gain valuable molecular in- Applied Testing (primarily forensics), Phar- Internet www.qiagen.com sights from samples containing the build- ma (pharma and biotech companies) and ing blocks of life. Our sample technologies Academia (life sciences research). Further Employees ~4.800 worldwide isolate and process DNA, RNA and proteins information can be found at: Founded (year) 1984 from blood, tissue and other materials. As- www.qiagen.com

survival of cancer patients. Qithera‘s R&D Name Qithera GmbH is based on new molecular findings from RWTH research and is implemented in close collaboration with the Hospital of RWTH Aachen University. By addressing internally validated target Address Auf der Pief 41a Qithera, Düsseldorf, Germany, is a “Busi- molecules that are known to abrogate ag- Postal Code/City 52134 Herzogenrath ness Angel Boost” that was founded by gressive characteristics of cancer (stem) Prof. Edgar Dahl (RWTH Aachen University) cells, Qithera is currently characterizing E-Mail [email protected] together with experienced biotech experts pharmacologically active compounds that Internet www.qithera.com of the BIO.NRW network. suppress tumor spreading. The first indica- The company is developing innovative tion of choice is a clinical important subset Employees < 5 drugs to suppress tumor progression of bladder cancer whose disease manage- Founded (year) 2012 and metastasis with the goal to improve ment has been stagnant for decades.

49 health and medicine BIO.NRW

set up a resource which prevents immune Name RheinCell Therapeutics GmbH rejections in a large number of recipient patients. Thus, this master cell bank serves Address Berghausener Str. 98 as “off the shelf”- platform for various types Postal Code/City 40764 Langenfeld of cell therapeutics and has the potential to become the starting material of any Fon +49 2173 3282080 RheinCell Therapeutics GmbH specializes future iPSC-based cell therapy in Europe Fax +49 2173 3282015 in the GMP-compliant generation of hu- and beyond. E-Mail [email protected] man, induced pluripotent stem cells (iPSC) Additionally RheinCell is advancing its Internet www.rheincell.de from allogeneic umbilical cord blood (CB). own therapeutic approach by developing The main focus is on setting up an iPSC retinal pigment epithelial cells for the treat- Employees 11 master cell bank from HLA homozygous ment of age-related macular degeneration Founded (year) 2017 CB units. The key idea behind is that only a in cooperation with a leading research limited number of iPSC lines are needed to institute (USA).

tive substance is loaded into the liver and Name Soluventis Nanotherapeutics GmbH into tumors in comparable concentrations. The targeting of metastases is excellent. Address Universitätsstrasse 136 The frozen ready-to-use Nanocarrier has Postal Code/City 44799 Bochum a long shelf life in ampoules whereas in The Soluventis-platform is a powerful drug the organism it is completely eliminated Fax +49 234 32 29125 delivery system, an entirely new type of within two days. Fon +49 234 32 14191 Nanocarrier characterized by high efficacy Soluventis has a portfolio of oncologic E-Mail soeren.schreiber@ and a good safety profile. siRNAs and has experience with different soluventis.de The Soluventis Nanocarrier shields drug candidates of customers. This novel Internet www.soluventis.com transported siRNA or other oligonucleo- drug delivery system opens the door to tides from blood and immune system and therapeutic oligonucleotides and we are Founded (year) 2018 reaches reliably target organs including facing the first clinical studies. poorly vascularized tumor tissue. The ac-

early out-licensing of product candidates Name Syntab Therapeutics GmbH after completion of the preclinical devel- Address St.-Jobser-Straße 56 opment. Syntab’s platform technology Postal Code/City 52146 Würselen enables the chemical synthesis of highly effective drugs against severe diseases Fon +49 171 6558374 such as cancer. The flexibility of the E-Mail info@syntab-therapeutics. Syntab Therapeutics is committed to the technology is based on the application com exploration and development of innovative of diverse highly specific binders against Internet www.syntab-therapeutics. drugs against severe diseases such as can- specific cell surface proteins. com cer. Syntab’s synthetic antibodies exhibit Furthermore, the technology has the all desirable properties of conventional potential to vary the number and specific Employees < 10 antibodies while, at the same time, being properties of binders and effectors that Founded (year) 2010 significantly smaller chemically accessible activate the immune system for each drug molecules. The company strives for the molecule.

50 BIO.NRW health and medicine

munological treatment used for many years, Name Transimmune AG mainly in cutaneous T cell lymphoma (CTCL), graft versus host disease (GVHD) and organ transplant rejection. Transimmune has creat- TRANSIMMUNE ed two core technologies; Transimmunization Address Königsallee 90 Transimmune AG is developing novel immu- and Transtolerization. These involve protocols Postal Code/City 40212 Düsseldorf notherapies based on its unique understand- for manipulating the immune system that ing of the physiologic processes underlying have been reduced to practice through our Fon +49 211 6413 6110 the activation of antigen presenting cells. This mouse-to-man development platform, gener- Fax +49 211 8693 1614 understanding derives from nearly 30 years ating compelling preclinical proof-of-concept E-Mail [email protected] of research into the mechanism of action data. These technologies have the potential to Internet www.transimmune.com behind Extracorporeal Photopheresis (ECP), significantly enhance current ECP practice as arguably the first FDA-approved cellular im- well as drive its application more broadly into Founded (year) 2012 munotherapy. ECP is a highly successful im- numerous other indications.

51 BIO.NRW

Industrial Biotechnology

52 BIO.NRW industrial biotechnology

numerous benefits to biocatalysis, the func- Name Autodisplay Biotech GmbH tionalisation of solid surfaces and screening applications. With its custom-tailored products and Address Merowinger Platz 1a services, Autodisplay Biotech is an ideal Postal Code/City 40225 Düsseldorf partner for leading companies in the chemical, pharmaceutical and biotechnology Fon +49 211 2095 1378 industries. Fax +49 211 9945 9636 Autodisplay Biotech GmbH is a biotechnol- E-Mail [email protected] ogy company commercializing its propri- Internet www.autodisplay-biotech.com etary expression platform for the display of heterologous proteins or peptides on Employees 9 the surface of gram negative bacteria. This Founded (year) 2008 cell surface display technology provides

tremolytes, these fascinating living beings Name bitop AG can thrive in the harshest habitats one can imagine: salt lakes, deserts, hot springs, the arctic ice or deep sea. With more than 25 years of experience Address Carlo-Schmid-Allee 5 and passion in the manufacturing of 100 % Postal Code/City 44263 Dortmund natural, pure and GMO-free extremolytes, bitop is a global market leader and expert in bitop is a reliable partner for the pharma, Fon +49 231 98 77 44-0 the biotechnological production and devel- animal health, cosmetics and life science Fax +49 231 98 77 44-10 opment of so called extreolytes. industry. We develop unique, extremolyte- E-Mail [email protected] Extremolytes are natural molecules, based medical products and concepts for Internet www.bitop.de which protect biological structures. They human and animal health and offer our raw are found inside of extremophilic plants material as multifunctional cosmetic active Founded (year) 1993 and microorganisms. Protected by ex - ingredients to our worldwide customers.

plied either as API or finished injectables, Name BSV Bioscience GmbH in co-operation with an also GMP approved German license manufacturer. Our main products are: Address Max-Planck-Strasse 12 – Human Chorionic Gonadotrophin (HCG), Postal Code/City 52499 Baesweiler – Human Menopausal Gonadotrophin BSV BioScience GmbH was founded in Oct. (HMG), Fon +49 2401 8047-10 2007 in Baesweiler, near the historical city – Follicle Stimulating Hormone (FSH), Fax +49 2401 8047-198 of Aachen. Since June 2010, the company – Urokinase (UK), Streptokinase and E-Mail [email protected] manufactures and markets biological phar- Ulinastatin (UTI). Internet www.bsvbio.de maceutical active ingredients for different BSV BioScience GmbH is focused on differ- therapeutic areas. ent R&D activities, continuously pursuing Employees 40 One of our key strengths is based on the improvements in the field of API´s and Founded (year) 2007 production of fertility hormones, being sup- finished dosage forms.

53 industrial biotechnology BIO.NRW

for these biomaterials to serve humans Name Cysal GmbH and animals. Cysal’s business strategy aims at out-licensing its technology plat- Address Mendelstraße 11 form to interested companies and/or Postal Code/City 48149 Münster offering its raw materials for incorpora- tion into consumer products for various Fon +49 251 980-2490 The innovative biotechnology company markets. Fax +49 251 980-2499 Cysal GmbH was founded as a spin-out of The main target markets are those for E-Mail [email protected] the University of Münster, Germany. energy food additives and sport nutrition, Internet www.cysal.de Cysal focuses on the production of novel cosmetics and skin care, dental hygiene, biomaterials in the area of biopolymers, clinical nutrition, immunomodulation, Employees 5 peptides, amino acids, and dipeptides on impotence and infertility, as well as in the Founded (year) 2012 an industrial scale at unprecedented low- area of animal feed production, especially cost, and also develops application fields for aquaculture.

pharma industries is offered. Product Name evoxx technologies GmbH development is based on the proprietary technology platform covering the whole Address Alfred-Nobel-Str. 10 value chain from early enzyme and pro- Postal Code/City 40789 Monheim am Rhein cess development to industrial scale pro- evoxx technologies GmbH, a German duction and product deregulation. Fon +49 2173 4099-40 Industrial Biotechnology Company, is evoxx industrial partners and custom- Fax +49 2173 4099-440 focusing on the development and produc- ers benefit from the unique metagenomics E-Mail [email protected] tion of industrial enzymes. As European libraries, the enzyme development skills Internet www.evoxx.com subsidiary of the global enzyme manu- and tech-transfer and production capa- facturer Advanced Enzymes Technologies bilities. evoxx is located on the Creative Employees 35 Ltd. a comprehensive product portfolio Campus in Monheim am Rhein and on Founded (year) 2006 of enzymatic solutions for human nutri- the Biotech Campus Hermannswerder in tion, animal nutrition, bio-processing and Potsdam.

product pipelines of natural product based Name IMAX Discovery GmbH novel taste modulators. IMAX Discovery is a subsidiary of Axxam SpA in Milano, Italy.

Address Otto-Hahn-Str. 15 Postal Code/City 44227 Dortmund IMAX Discovery is a research driven com- Fon +49 231 9742-6440 pany, creating new product innovation Fax +49 231 9742-7401 through the generation and development E-Mail [email protected] of novel and natural flavour compounds for Internet www.imaxdiscovery.com the food and beverage industry. Using our strong technology platforms and expertise Founded (year) 2010 around taste receptors and natural products IMAX Discovery generates proprietary

54 BIO.NRW industrial biotechnology

information content, and are approved for Name m2p-labs GmbH bacterial, yeast, fungi, plant and insect cells. The BioLector® Pro with its microfluidic chip technology, continuously controls the Address Arnold-Sommerfeld-Ring 2 pH value of each culture individually as Postal Code/City 52499 Baesweiler well as the feeding for realizing fed-batch m2p-labs high-throughput microbioreac- cultivations. Fon +49 2401 805-330 tors (BioLector®) provide intelligent, online The microbioreactor systems combined Fax +49 2401 805-333 monitored (biomass, fluorescence, pH and with a standard liquid handling robot E-Mail [email protected] DO) micro fermentation technology for (RoboLector®) allow automated micro fer- Internet www.m2p-labs.com screening and bioprocess development. mentation of the whole bioprocess. The systems increase the number of Employees 36 microbial experiments (aerobic/micro- Founded (year) 2005 aerophilic/strict anaerobic) as well as the

tamination agents for consumer markets, Name multiBIND biotec GmbH hospitals, laboratories and agrochemistry. bioDECONT® and bioCLEAN are the only agents that in addition to the effective kill- Address Gottfried-Hagen-Str. 60-62 ing of microorganisms also accomplish safe Postal Code/City 51105 Köln and complete decontamination and non- enzymatic degradation of genetic material Fon +49 221 2780-211 multiBIND develops innovative decon - (DNA/RNA). Fax +49 221 2780-213 tamination, disinfection and hygiene so- These innovative solutions are nontoxic E-Mail [email protected] lutions for molecular biology, healthcare for humans, non-corrosive and free of or- Internet www.multibind.de and agriculture. The R&D work constantly ganic solvents or other hazardous chemicals. generates exclusive, confidential know- multiBIND pursues a strict partnering strat- Employees 3 how, international patents and new patent egy with international licenses for products Founded (year) 2005 applications for disinfection and decon- in all suitable markets and industrial sectors.

is on the development of intelligent mix- Name Senzyme GmbH tures of hydrolases, to be used in a most efficient degradation of plant material, e.g. in the course of methane production Address Gierlichsstr. 6 from biomass. Postal Code/City 53840 Troisdorf

Fon +49 2241 9715-2000 Fax +49 2241 9715-2499 Senzyme GmbH develops and produces E-Mail [email protected] technical enzymes and other micro- Internet www.senzyme.de biological products, all of which is well grounded in the company’s substantial Employees 30 experience in solid-state fermentation us- Founded (year) 2000 ing filamentous fungi. Currently, the focus

55 industrial biotechnology BIO.NRW

modelling and simulations to successfully Name SeSaM-Biotech GmbH increase your enzyme’s performance. SeS- aM-Biotech tunes enzyme properties like activity, thermal resilience, protease resistance, solvent/pH stability, and substrate/ Address Forckenbeckstraße 50 product inhibition. The track record of 10 Postal Code/City 52074 Aachen years of successful protein engineering includes proteases, monooxygenases, lipases, Fon +49 241 93856979 SeSaM-Biotech is dedicated to the directed cellulases, amylases, phytases, esterases, E-Mail [email protected] evolution of enzymes. Our comprehensive glucose oxidases, pectinases, isomerases, Internet www.sesam-biotech.com evolution strategy KnowVolution as part of laccases, and xylanases being applied in the the QuESt-Service offers the best combi- biotechnological sectors pharma, chemistry, Founded (year) 2008 nation of patented mutagenesis technolo- cosmetics, flavors, nutrients, feed, laundry, gies and rational design by computational food/beverages, biofuel, textiles and paper.

velopment – fermentation – DSP – enzyme Name W42 Industrial Biotechnology GmbH immobilisation – biocatalytic process development. Since 2005 W42 GmbH has carried out many successful projects for industrial Address Otto-Hahn-Straße 15 partners in Europe and P.R. China. Several Postal Code/City 44227 Dortmund W42 GmbH is your partner for enzyme pro- improved strains are running on industrial duction and process development. We offer: scale for production of technical enzymes. Fon +49 176 82182604 High performance heterologous protein Recently W42 has established a European E-Mail [email protected] production in Pichia sp. Wide range of differ- Network for the development, production, Internet www.w42biotechnology.de ent strains and promoters – best choice for licensing and marketing of vaccines for ani- your project. Methanol dependent and cus- mal health with focus on aquaculture sector. Employees 3 tomer specific ‘fine-tuning’ process control Focus is the development of 2nd generation Founded (year) 2005 for high yield protein production. Complete recombinant vaccines. We are offering com- processes are offered including: strain de- plete service for your vaccine candidate.

56 BIO.NRW industrial biotechnology

57 BIO.NRW

Agrobiotechnology

58 BIO.NRW agrobiotechnology

tations. Our patent pending gene therapy Name AgroJector UG technologies will radically improve the pre- cision and safety of crop improvements in generating higher yielding, pest resistant, Address Nattermannallee 1 drought/cold tolerant plants as well as Postal Code/City 50829 Köln plants with improved nutrition quality and The most commonly used tools, including industrial characters. Fon +49 176 618 213 95 the recently developed genome editing The company aims at introducing desir- technologies, are behind the expectations able, lost, wild genes back to highly-bred, E-Mail [email protected] of science and society for genetically im- elite crops or correcting faulty genes in Internet www.agrojector.com proving plants regarding targeting speci- such elite crops. Our technologies are not ficity, full editing capability and stringent limited to plant science but can also po- Employees 2 biosafety. AgroJector is an ag-biotech tentially be applied in human gene therapy. Founded (year) 2014 company focused on addressing these limi-

from pathogens. We developed a patented Name AgroProtect GmbH platform based on antibody fusions which ensures plant protection from fungal and bacterial infections. This alternative approach for controlling plant pathogens and Address Forckenbeckstraße 6 parasites aims at minimising the costs for Postal Code/City 52074 Aachen cultivation of crops thereby reducing the toxic effects of pesticides and toxins for Fon +49 2451 914 8783 It is estimated that plant pathogens are re- human beings. Fax +49 2451 914 8784 sponsible of world-wide losses in the range AgroProtect GmbH licences its propri- E-Mail [email protected] of billions of euros per year. Therefore, etary technology and offers the genera- Internet www.agroprotect.de there is a strong need to provide effective, tion of pathogen resistant plants as well broad range and environmentally friendly as access to novel resistant cultivars of Founded (year) 2010 approaches to ensure protection of plants several crops.

turf grasses, and different intercrop spe- Name Deutsche Saatveredelung cies. Breeding is run on nine breeding AG (DSV) stations in Europe and two in Canada. We are dedicated to our purpose: Innovation Address Weissenburger Straße 5 for your growth. Seed of new varieties is Postal Code/City 59557 Lippstadt produced and processed mostly in Europe Deutsche Saatveredelung AG is an inter- and sold world-wide. Fon +49 2941 296-0 national plant breeding company with In the framework of several coopera- Fax +49 2941 296-100 headquarters in Germany. The main focus tions in breeding, production, marketing E-Mail [email protected] is on research and development in breed- and sales DSV is partner of several com- Internet www.dsv-seeds.com ing and seed production for different crop petitive enterprises on the national and plant species. international level. Employees 600 Our major products include rapeseed, Founded (year) 1923 wheat, barley, corn/maize, pasture and

59 agrobiotechnology BIO.NRW

ready within the mycological product range Name MykoMax GmbH several self-developed mycorrhiza-inoculi. On short and medium-term the company Address Flieth 39 MykoMax GmbH would development new Postal Code/City 42327 Wuppertal drugs from medicinal effective mush - rooms for the pharmaceutical use. There- Fon +49 202 3171-320 by the company uses a self-developed Fax +49 202 3171-3210 method for the extraction of the active E-Mail [email protected] The company MykoMax was created in ingredients in the mushrooms. Internet www.mykomax.de October 1999 in the legal form of a limited company (GmbH). The enterprise article of Employees 3 the society is the study, development and Founded (year) 1999 production of biotechnology products on the basis of fungi. The company offers al-

to improve plants by protoplast fusion and Name Phytowelt GreenTechnologies GmbH double haploid production. Such breeding progress accelerating techniques allow Address Kölsumer Weg 33 Phytowelt to increase plant biomass pro- Postal Code/City 41334 Nettetal duction, what lays the foundation for an innovative biorefiniery concept soon to be Fon +49 2162 77859 Phytowelt operates industrial plant bio- realized. Fax +49 2162 89215 technology. It is a leading provider for the The USP of a big poplar collection com- E-Mail [email protected] identification and expression of genes bined with a unique fermentation process Internet www.phytowelt.com encoding plant enzymes. This enzymes for terpenes in E.coli, especially carot - offer new possibilities for industrial fer- enoids, is a big success factor for Phytowelt. Employees 30 mentation, targeting fatty acids, terpenoids The raspberry flavour, R-Alpha-Ionone will Founded (year) 1998 and plant P450 enzymes. Additionally, be one of the first products fermentatively Phytowelt offers solutions in plant breeding produced.

crops is strongly build upon innovation. Name Saaten-Union BIOTEC GmbH Application of tissue culture technolo - gies (doubled haploids, embryo rescue) Address Hovedisser Str. 94 and molecular marker applications are Postal Code/City 33818 Leopoldshöhe routinely used in a wide range of crops and Fon +49 5208 95971-0 for a significant number of breeding traits. Fax +49 5208 95971-96 E-Mail info@saaten-union- biotec.com Internet www.saaten-union- Saaten-Union Biotec offers services and biotec.de contract research in the field of plant Employees 80 breeding (rapeseed, barley, wheat, triti Founded (year) 1984 cale, oat, potato). The development of new varieties of cereals, rapeseed and other

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BIO Clustermanagement NRW GmbH phone: +49 (0) 211 942 150 49 Merowingerplatz 1 mail: [email protected] 40225 Düsseldorf, Germany web: www.bioclustermanagement.de BIO.NRW

Bioinformatics

62 BIO.NRW bioinformatics

3D, visualize G and S effects, see whether D D Name BioSolveIT your torsions are unusual etc., keep ADME properties in focus – get answers with light- weight software tools that run fast on any Address An der Ziegelei 79 chemist’s computer. Or get new inspiration Postal Code/City 53757 Sankt Augustin during finding novel compounds in chemical spaces. Fon +49 2241 25250 BioSolveIT’s Services department offers Fax +49 2241 25255-25 Modeling outsourcing, which was proven E-Mail [email protected] BioSolveIT = Fast, Visual, Easy to Use Med- successful in many projects with research or- Internet www.biosolveit.de Chem software. ganisations from universities to big pharma This is our mantra for MedChem software companies. Employees 17 in lead optimization and hit finding. Be sur- Founded (year) 2001 prised by rescaffoldings, play with ligands in

The high-throughput techniques performed Name IIT BioTech - Institut für by Illumina HiSeq and MiSeq or by IonTorrent Innovationstransfer an der PGM can be offered combined with a power- Universität Bielefeld GmbH ful lab & bioinformatic pipeline providing full service tasks like genomic assembly, gap Address Universitätsstr. 25 closure and annotation. University of Bielefeld Furthermore we offer individual solutions Postal Code/City 33615 Bielefeld for the bioinformatic evaluation of project Fon +49 521 106 8756 data. This includes construction of draft- Fax +49 521 106 89041 The Institut für Innovationstransfer GB genomics, storage/care of genome projects, E-Mail [email protected] Biotech (IIT Biotech) offers integrated analysis in resequencing and metagenomics Internet www.iit-biotech.de genomic services. Since some years the and development/customization of analysis- Employees 14 main provided service is the ’next genera- software. Founded (year) 1995 tion sequencing’.

changes the way infection causative mi- Name Noscendo GmbH crobes are identified. Introducing a para- digm shift using proprietary algorithms and software harnessing next generation sequencing of cell free nucleic acids isolated Address Königstr. 34 from patient samples Noscendo brings the Postal Code/City 47198, Duisburg concept of liquid biopsy into the field of infectious diseases. Fon +49 2066 50687 80 Noscendo’ s software solution is capable of E-Mail [email protected] In order to successfully treat the infected differentiating infection from non-infectious Internet www.noscendo.com patient, you have to recognise and diagnose signals and thereby aiding intensive care most reliably the infecting microbe. clinicians in their daily task to find the right Employees <10 Noscendo GmbH, a Duisburg (Germany) decisions, enabling a targeted and successful Founded (year) 2017 based molecular diagnostics company, treatment in an actionable timeframe.

63 bioinformatics BIO.NRW

Q-USDTM integrates all amounts and kinds Name Qlaym GmbH of patient data regardless from their source – like micro array data for gene Address Merowingerplatz 1 expression, SNP and CNV data, medical Postal Code/City 40225 Düsseldorf images, preclinical and clinical study data – and extracts systematics with a predic- Fon +49 211 88280-00 tive value for the predefined outcome Fax +49 211 88280-022 (e.g., efficacy, side effects). E-Mail [email protected] As the predictability of any outcome Internet www.qlaym.com QLAYM´s technology platform Q-USD™ correlates to not only one or two variables (Qlaym-Unsupervised Solution Discovery) but a network of variables, we are dealing Employees 20 creates value by identifying Predictive with complex multi-variable and interde- Founded (year) 2011 Systematics in complex data enabling pendent systems. critical decision-making.

Authority (e.g., RKI, RIVM, HPA, Serum Stat- Name Ridom GmbH ens) has bought in the last 10 years and is using since then at least one software product from Ridom. Address Mendelstr. 11 Ridom has pioneered typing efforts with a Postal Code/City 48149 Münster software tool for Staphylococcus aureus. The company has developed and maintains the Fon +49 251 490931-50 The Ridom GmbH (Münster, Germany) was worldwide largest sequence-based microbial Fax +49 251 490931-51 founded January 2003. The company devel- typing database (Ridom SpaServer). The SPA E-Mail [email protected] ops software for DNA re-sequencing analysis typing software Ridom StaphType is currently Internet www.ridom.de for physicians and epidemiologists on routine used by approximately 400 users in 36 dif- basis. The company has in the meantime by its ferent countries worldwide. The new Ridom Employees 4 software products a well-recognized name in SeqSphere+ software provides a bacterial Founded (year) 2003 the field of sequence based microbial typing; typing solution for any bacteria, any study e.g., every European National Health System type, any lab.

64 BIO.NRW bioinformatics

65 BIO.NRW

Other Biotechnologically Active Companies

66 BIO.NRW other

Bayer is committed to the principles of Name Bayer AG sustainable development and to its social and ethical responsibilities as a corporate citizen. In fiscal 2017, the Group employed around 99,800 people and had sales of 35.0 billion euros. Capital expenditures Address Kaiser-Wilhelm-Allee Bayer is a global enterprise with core com- amounted to 2.4 billion euros, R&D ex- Postal Code/City 51368 Leverkusen petencies in the life science fields of health penses to 4.5 billion euros. care and agriculture. Its products and For more information, go to www.bayer.com. Fon +49 214 30-1 services are designed to benefit people and improve their quality of life. Internet www.bayer.com At the same time, the Group aims to create value through innovation, growth and Employees 99,800 high earning power.

vative prowess and integrated technology Name Evonik Industries AG platforms. Evonik is active in over 100 countries around the world. In fiscal 2015 more Address Rellinghauser Str. 1-11 than 33,000 employees generated sales Postal Code/City 45128 Essen Evonik, the creative industrial group from of around €13.5 billion and an operating Germany, is one of the world leaders in profit (adjusted EBITDA) of about €2.4 Fon +49 201 177 01 specialty chemicals. Profitable growth billion. Fax +49 201 177 3475 and a sustained increase in the value of Evonik innovates and serves the bioec- E-Mail [email protected] the company form the heart of Evonik’s onomy markets. Products are i. a. Biolys®, Internet www.evonik.com corporate strategy. Its activities focus DYNACOLL® Terra, DYNAPOL ® Terra, on the key megatrends health, nutrition, RESOMER®, ThreAMINO®, TrypAMINO®, Employees 33,000 resource efficiency and globalization. and VESTAMID® Terra. Founded (year) 2007 Evonik benefits specifically from its inno-

The main focus is on oilseed rape, potatoes, Name German Seed Alliance corn, sunflower, grasses, peas and cere- GmbH als (especially wheat, barley, rye, oat and triticale). German Seed Alliance coordinates Address Aachener Str. 1053-1055 all research programs of the group and is Postal Code/City 50858 Köln German Seed Alliance GmbH is an alliance partner of the national and international of four leading German plant breeding scientific community in plant research and Fon +49 221 162 506-0 companies in international agriculture: biotechnology. New varieties are developed Fax +49 221 162 506-29 Deutsche Saatveredelung, Norddeutsche and high quality seeds are produced for dif- E-Mail [email protected] Pflanzenzucht, Nordsaat Saatzucht and ferent climate regions. In sales the first focus Internet www.german-seed-alliance.de SaKa. The company and its shareholders are is on Russian Federation, with innovative internationally experienced enterprises in solutions and wide range of seed products Employees 45 the field of plant research and development, combined with professional service and Founded (year) 2008 breeding, seed production and distribution. individual consultancy.

67 other BIO.NRW

record of bringing innovative pain treat- Name Grünenthal GmbH ments and state-of-the-art technologies to patients. By sustainably investing in our R&D above the industrial average, we are Address Zieglerstr. 6 strongly committed to innovation. Postal Code/City 52099 Aachen Grünenthal is an independent, family- Grünenthal is an entrepreneurial, science- owned company headquartered in Aachen, Fon +49 241 569-0 based pharmaceutical company specialized Germany. We are present in approx. 30 E-Mail [email protected] in pain, gout and inflammation. Our ambi- countries with affiliates in Europe, Latin Internet www.grunenthal.com tion is to deliver four to five new products America and the US. Our products are sold to patients in diseases with high unmet in more than 100 countries and approx. Employees 5,200 worldwide medical need by 2022 and become a € 2 bn 5,200 employees are working for Grünenthal Founded (year) 1946 company. We are a fully integrated research worldwide. In 2017, Grünenthal achieved & development company with a long track revenues of approx. € 1.3 bn.

In its Laundry & Home Care and Beauty Name Henkel AG & Co. KGaA Care businesses, Henkel holds leading positions in many markets and categories around the world. Founded in 1876, Hen- Address Henkelstr. 67 kel looks back on more than 140 years of Postal Code/City 40191 Düsseldorf Henkel operates globally with a well- success. balanced and diversified portfolio. The Henkel employs more than 50,000 Fon +49 211 7979 630 company holds leading positions with its people globally and reported sales of Fax +49 211 7982 245 three business units in both industrial and 20,0 bn euros in fiscal year 2017. Henkel’s Internet www.henkel.com consumer businesses thanks to strong preferred shares are listed in the German brands, innovations and technologies. stock index DAX. Employees 50,000 Henkel Adhesive Technologies is the Founded (year) 1876 global leader in the adhesives market – across all industry segments worldwide.

and evaluate programmes that improve Name Janssen GmbH therapies beyond the mere administration of drugs. Janssen is dedicated to address- Address Johnson & Johnson Platz 1 ing and solving the most important unmet Postal Code/City 41470 Neuss medical needs of our time, including oncology, immunology, neuroscience and infec- Fon +49 2137 9550 tious diseases. Fax +49 2137 955599 Janssen is a research-based pharmaceuti- Driven by our commitment to patients, Internet www.janssen.com/germany cal company that develops and markets we develop sustainable, integrated health- pharmaceutical products and services. care solutions by working side-by-side with Employees 900 (Germany), The Janssen Pharmaceutical Companies of healthcare stakeholders, based on partner- 40,000 (worldwide) Johnson & Johnson with worldwide 40,000 ships of trust and transparency. More infor- Founded (year) 1959 employees develop innovative medicines for mation can be found at www.janssen-emea. the treatment of severe chronic conditions com and www.janssen.com/germany.

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an “Excellence company for Training and Name Pharma Waldhof GmbH Talent Management”. Development of new products using cutting-edge technology enables us to apply our high standards and Address Hansaallee 159 quality values into innovative, powerful and Postal Code/City 40549 Düsseldorf Since 70 years, Pharma Waldhof GmbH, lo- well-accepted products designed for existing cated in Düsseldorf/Germany, is active in the and new markets. Fon +49 211 52602-0 unique world of Nucleic Acid Biochemistry. Our success is based on our highly skilled Fax +49 211 52602-60 The last milestones in our long company people and pursuit for delivering quality E-Mail [email protected] history were in 2014 and 2016 the award of value added products serving the worldwide Internet www.pharmawaldhof.de the label “Innovative through Research” by market in various segments like Pharma APIs the “Stifterverband für die deutsche Wis- and Intermediates; Cosmetics; Nutrition and Employees 13 senschaft” and in 2015 the acknowledge- Diagnostics. Pharma Waldhof belongs to the Founded (year) 1974 ment by the “Deutscher Bildungspreis” as multi-national Aceto Group/USA.

enhancing biodiversity and revitalizing Name Syngenta Seeds GmbH rural communities. To learn more visit www.syngenta. com and www.goodgrowthplan.com. Fol- Address Zum Knipkenbach 20 low us on Twitter® at www.twitter.com/ Postal Code/City 32107 Bad Salzuflen Syngenta is a leading agriculture company Syngenta. helping to improve global food security Fon +49 5222 5308-0 by enabling millions of farmers to make E-Mail internet.marketing@ better use of available resources. syngenta.com Through world class science and inno- Internet www.syngenta.de vative crop solutions, our 28,000 people in over 90 countries are working to trans- Employees 150 form how crops are grown. We are com- Founded (year) 2000 mitted to rescuing land from degradation,

biological pathways involved in severe Name UCB Pharma GmbH diseases. The complexities of severe UCB Biosciences GmbH diseases are beyond the expertise and resources of a single organisation. Developing and commercialising in - Address Alfred-Nobel-Str. 10 UCB is a global biopharmaceutical com- novative therapies is often the result of Postal Code/City 40789 Monheim pany focusing on severe diseases in two strong partnerships. That is why we value therapeutic areas – CNS and immunol- partnering with leading academic, biotech Fon +49 2173 4848-48 ogy. UCB also has a selective presence in and pharma companies to bring new solu- Fax +49 2173 4848-41 primary care. tions for patients. There is no such thing E-Mail [email protected] UCB is connecting science in new ways, as an “average patient”. We are seeking to Internet www.ucb.com; www.ucb.de notably chemistry and biology, so that embed the real needs of specific patient they can leverage the potential of these populations in our science and innovation Founded (year) 1928 (Belgium) two disciplines, as well as illuminate the process.

other BIO.NRW

C N WvB is nowadays well known for strong

Name W. von Borries-Eckendorf E

GmbH & Co. KG K breeding programs in oilseed rape, barley T Pflanzenzuchtbetrieb E and high yielding wheat varieties.

N R The company based in Lippe is founding

Address Hovedisser Strasse 94 D O member of the Rapool Ring GmbH and the Postal Code/City 33818 Leopoldshöhe O S Saaten-Union Biotec GmbH. R Fon +49 5208 9125-30 F E R Along with other breeding companies, Fax +49 5208 9125-49 Eckendorf is significantly involved in one E-Mail [email protected] of the largest distributors in the German Internet www.wvb-eckendorf.de W. von Borries-Eckendorf is a medium-sized sector of seed, the Saaten-Union GmbH. family-owned company, founded in 1849 by Employees 40 Wilhelm von Borries (1805-1890), a promi- Founded (year) 1849 nent farmer and talented plant breeder. Starting with the “Eckendorfer” fodder beet,

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magnis dis parturient montes, nascetur ridiculus mus. complementing their data.

Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et Rhine Westphalia listed. The organizations are currently in the process of up-dating and

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Information umfasst Firmenproﬁle, Kontaktdetails, sowie einer Zusammenfassung der zur Verfügung. Die Information umfasst Firmenproﬁle, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien.

Life Science und Biotechnologieﬁrmen aus Nordrhein-Westfalen zur Verfügung. Die BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der Life Science und Biotechnologieﬁrmen aus Nordrhein-Westfalen

BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der

Erweiterte Suche Show Details

bioprocesses.

Firmenname

optimize and control their

research to better understand,

biotechnological and chemical

in Nordrhein-Westfalen

scientists in pharmaceutical,

fermentations. The company enables

• Laboratory equipment Biotech-Unternehmen

the analysis of shake-ﬂ ask

Subsector

development of laboratory devices for

company that focuses on the

aquila biolabs is a German technology Supplier & Engineering

Main Sector

BIO.NRW Description other

Baesweiler, North Rhine-Westphalia, Germany

aquila biolabs GmbH

Datenbanken

Unsere

Wissen

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bioprocesses.

optimize and control their

research to better understand,

biotechnological and chemical

Alle Veranstaltungen www.bio.nrw.de scientists in pharmaceutical,

fermentations. The company enables

• Laboratory equipment

the analysis of shake-ﬂ ask

Subsector

development of laboratory devices for

company that focuses on the

aquila biolabs is a German technology Supplier & Engineering

ZENIT GmbH, Mülheim an der Ruhr 09 Konversationen

Main Sector Description

große Chancen auf.

Baesweiler, North Rhine-Westphalia, Germany Industrie. Insbesondere im Bereich der Gesundheitswirtschaft tun sich für NRW-Unternehmen

2017 aquila biolabs GmbH companyJapan und Süd-Korea sinddat wichtige Absatzmärkte und Investitionsstandorteaba für die deutsche se

13. Juli

Marktchancen Japan / Südkorea

RWI4, Düsseldorf 04 Konversationen

Show Details

IngredientsWissenschaftsdatenbank - HiPerIn” durch CLIB2021Firmendatenbank organisiert. Downloads DE | EN Wissenschaftsdatenbank Firmendatenbank Downloads DE | EN

Dieses Forum wird im Rahmen des Projekts “Biotechnological Concepts for High Performance

• Proteomics

2017 Das nächste CLIB Forum befasst sich mit biotechnologischen Innovationen für Beschichtungen.

• Genomics

MS,...

06. Juli OK Newsletter-Anmeldung OK Newsletter-Anmeldung • Diagnostic instrumentation

CLIB-HiPerIn Forum “Biotech Innovations for Coatings” Pyrosequencing ® Technology, HPLC /

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services oﬀ ered by the company

Cluster Aktuelles Veranstaltungen Standort Finanzierung Kontakt • Biochips CeNTech, Münster 12 Konversationen

Aktuelles Veranstaltungen Standort analysisFinanzierung and bioinformatics. KontaktThe • Analytical services Subsidiary

culture management, HPLC / MS

• Other

Public (listed on stock exchange) Pyrosequencing® technology, cell

05.07.2017, ab 12:30 Uhr im Centrum für Nanotechnolog Subsector

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ﬁndet am Mittwoch, den „Liquid Biopsy – Vom Analyten über die Analytik zur Anwendung“ 57 Ergebnisse sortiert nach Firmennamen Sortieren nach: Firmenname

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is a service laboratory with emphasis

2017

13. Arbeitsplattform des thematischen Schwerpunktes BIO.NRW.red zum Thema

arrows biomedical Deutschland GmbH Biotechnology / R&D Services [select all] Ownership

05. Juli

Main Sector Description 13. Arbeitsplattform „Liquid Biopsy" aquila biolabs GmbH

Biotech- Baesweiler, North Rhine-Westphalia, Germany

0 100.000

Köln, North Rhine-Westphalia, Germany

Employees worldwide arrows biomedical Deutschland GmbH

06 Konversationen San Diego Convention Center, USA Unternehmen Main Sector Description Supplier & Engineering aquila biolabs is a German technology

in Nordrhein- company that focuses on the 50 200

Biotechnology NRW cordially invite you visit us at our booth (4507) in the German Pavilion. development of laboratory devices for

Herzlich Willkommen Employees at domicil Subsector 2017 the analysis of shake-ﬂ ask

The Government of the German State of North Rhine-Westphalia (NRW) and BIO.NRW Cluster Westfalen • Laboratory equipment fermentations. The company enables

19. - 22. Juni

Show Details BIO International Convention 2017 On the market scientists in pharmaceutical, in Nordrhein-Westfalen biotechnological and chemical

Phase III research to better understand,

dem (Bundes)land der Biotechnologie CompanyPhase nameII

optimize and control their bioprocesses.

Veranstaltungen

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optimize and control their

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research to better understand,

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biotechnological and chemical Veranstaltungen

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fermentations. The company enables

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AdvancedIndirect (independent Search dealer) the analysis of shake-ﬂ ask

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development of laboratory devices for

FreeDirect text (own sales force)

company that focuses on the

[select all] Distribution aquila biolabs is a German technology Supplier & Engineering Main Sector

Ares BioscienceDescription GmbH

Alle Nachrichten

MainPhysicians sector / doctors Köln, North Rhine-Westphalia, Germany

Baesweiler, North Rhine-Westphalia, Germany BiotechnologyLarge medtech - Therapeutics and Diag…

Main Sector aquila biolabsDescription GmbH

Large biotech and big Pharma Biotechnology / R&D Services Ares Bioscience GmbH is a

05. bis 06.04.2017 in Hannover Subsector [select all]

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Biochips • Other market. The company provides PCR

Other

08. Juni 2017

Forschung, Unternehmen, Investoren und Politik aus den in NRW traditionell starken Industrien 05.stabiles Juni und 2017 dauerhaftes Netzwerk aus Experten • Analytical services

Bioinformatics Show Detailsenzymes, restriction enzymes,

[select all] auf Landesebene, national und international. Energie, Stahl und Chemie. der roten Biotechnologie. Customer segments • Synthesis services nucleotides, DNA/RNA modifying

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DiagnosticResearch on Instrumentation contract basis BIO.NRW.academy am 3. Mai in Hamm

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mehr erfahren mehr erfahren mehr erfahren MS,...electrophoresis. Fit für die Zukunft? Max-Planck-Institute feiern

R&D

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• Cell culture 09. Juni 2017 06. Juni 2017

( Microarray s), RT-qPCR / general PCR,

Out-licensing

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Primary therapeutic areas [select all] Show Detailsinclude Gene and protein analysis

services oﬀ ered by the company • Biochips Manufacturer

analysis and bioinformatics. The Aviv auf Understanding Cardiovascular • Analytical services

In-licensing

culture management, HPLC / MS

• Other Kooperationsscout nimmt Arbeit in Tel

unterzeichnet Memorandum of Conditions originating in the perinatal pe…

Aktuelles Pyrosequencing® technology, cell

Subsector

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NRW-Investitions- und Delegation der China Medical City

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[select all] Business Model is a service laboratory with emphasis 12. Juni 2017 07. Juni 2017

arrows biomedical Deutschland GmbH

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Nachrichten Digestive system arrows biomedical Deutschland GmbH

Main Sector

Köln, North Rhine-Westphalia,Description Germany Wissenschaft und Wirtschaft

BIO.NRW Cluster Diseases of the blood and blood-forming… Diseases of the ear

Diseases of the ear Diseases of the blood and blood-forming…

Wissenschaft und Wirtschaft BIO.NRW Cluster Main Sector Köln, North Rhine-Westphalia,Description Germany

arrows biomedical Deutschland GmbH

Digestive system Biotechnology / R&D Services arrows biomedical Deutschland GmbH

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Aktuelle Business Model [select all] is a service laboratory with emphasis 12. Juni 2017 07. Juni 2017 Congenital malformations, deformations… on gene and protein analysis, Other

NRW-Investitions- und Delegation der China Medical City Subsector Pyrosequencing® technology, cell Conditions originating in the perinatal pe… Aktuelles • Other Kooperationsscout nimmt Arbeit in Tel unterzeichnet Memorandum of In-licensing culture management, HPLC / MS

• Analytical services

Aviv auf Understanding Cardiovascular analysis and bioinformatics. The

Manufacturer • Biochips services oﬀ ered by the company

[select all] Primary therapeutic areas • Bioinformatics Show Detailsinclude Gene and protein analysis Out-licensing • Cell culture ( Microarray s), RT-qPCR / general PCR,

09. Juni 2017 06. Juni 2017 Pyrosequencing ® Technology, HPLC /

R&DGenomics • Diagnostic instrumentation

Max-Planck-Institute feiern Fit für die Zukunft? MS,...electrophoresis. mehr erfahren mehr erfahren mehr erfahren • Genomics

biology, and reagents for ResearchDiagnostic on Instrumentation contract basis

Millionenförderung vom Europäischen BIO.NRW.academy am 3. Mai in Hamm • Proteomics

Innovative biotech companies in North Rhine-Westphalia. BIO.NRW offers free ofmarkers, charge products for molecular a well-or-

Cell culture Forschungsrat enzymes, DNA molecular weight

nucleotides, DNA/RNA modifying

Customer segments [select all] • Synthesis services

Bioinformatics

auf Landesebene, national und international. Energie, Stahl und Chemie. der roten Biotechnologie.

Show Detailsenzymes, restriction enzymes,

Other • Analytical services

market. The company provides PCR

Forschung, Unternehmen, Investoren und Politik aus den in NRW traditionell starken Industrien

08. Juni 2017 05.stabiles Juni und 2017 dauerhaftes Netzwerk aus Experten • Other Biochips

biology products to life sciences BIO.NRW aktiviert Kooperationen zwischen …ist eine sich dynamisch entwickelnde Technologie BIO.NRW.red als strategische Initative für ein ganized and comprehensive database of life science and biotechConsumer (mass market) companiesSubsector resident in North Rhine-

EU-Darlehen für Biofronteras Nachbericht - Die Deutschen

develops and markets molecular Analytical services

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Ares Bioscience GmbH is a 05. bis 06.04.2017 in Hannover Biotechnology / R&D Services

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Westphalia. The database currently includes 450 company profiles, contact detailsaquila biolabsDescription GmbHand a summary of BiotechnologyLarge medtech - Therapeutics and Diag…

Baesweiler, North Rhine-Westphalia, Germany

Main sector

Physicians / doctors Köln, North Rhine-Westphalia, Germany Alle Nachrichten Ares Bioscience GmbH Main Sector Description products, services and technologies and is updated frequently several timesSupplier & Engineering per year.aquila biolabs is a German technology Distribution [select all]

company that focuses on the FreeDirect text (own sales force) development of laboratory devices for

Subsector the analysis of shake-ﬂ ask AdvancedIndirect (independent Search dealer)

• Laboratory equipment fermentations. The company enables Show Detailsscientists in pharmaceutical, Veranstaltungen Biotech [select all] Medtech [select all] biotechnological and chemical research to better understand, Preclinical In development

optimize and control their phone: +49 211 38 54 69-9200 • E-Mail: [email protected].

Phase I On the market bioprocesses.

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in Nordrhein-Westfalen

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BIO International Convention 2017

fermentations. The company enables

19. - 22. Juni Westfalen • Laboratory equipment

the analysis of shake-ﬂ ask

2017 The Government of the German State of North Rhine-Westphalia (NRW) and BIO.NRW Cluster Employees at domicil Subsector

Herzlich WillkommenBiotechnology NRW cordially invite you visit us at our booth (4507) in the German Pavilion. 50 200 development of laboratory devices for in Nordrhein-

company that focuses on the

aquila biolabs is a German technology Supplier & Engineering

Main Sector Description

San Diego Convention Center, USA 06 Konversationen EmployeesUnternehmen worldwide arrows biomedical Deutschland GmbH

0 100.000 Köln, North Rhine-Westphalia, Germany

Biotech- Baesweiler, North Rhine-Westphalia, Germany

13. Arbeitsplattform „Liquid Biopsy" Main Sector aquila biolabsDescription GmbH 05. Juli Ownership [select all] Biotechnology / R&D Services arrows biomedical Deutschland GmbH

is a service laboratory with emphasis

2017 13. Arbeitsplattform des thematischen Schwerpunktes BIO.NRW.red zum Thema Private / independent

57 Ergebnisse sortiert nach Firmennamen Firmenname „Liquid Biopsy – Vom Analyten über die Analytik zur Anwendung“ ﬁndet am Mittwoch, den on gene and proteinSortieren analysis, nach: Subsector 05.07.2017, ab 12:30 Uhr im Centrum für Nanotechnolog Public (listed on stock exchange) Pyrosequencing® technology, cell • Other culture management, HPLC / MS

Subsidiary • Analytical services Veranstaltungen Standort Finanzierung Kontakt Aktuelles analysis and bioinformatics. The

CeNTech, Münster 12 Konversationen Cluster s Veranstaltungen Standort Finanzierung Kontakt Aktuelle • Biochips services oﬀ ered by the company • Bioinformatics include Gene and protein analysis Search Clear • Cell culture ( Microarray s), RT-qPCR / general PCR,

• Diagnostic instrumentation Pyrosequencing ® Technology, HPLC / Newsletter-Anmeldung

CLIB-HiPerIn Forum “Biotech Innovations for Coatings” OK Newsletter-Anmeldung OK MS,... 06. Juli • Genomics 2017 Das nächste CLIB Forum befasst sich mit biotechnologischen Innovationen für Beschichtungen. • Proteomics

Dieses Forum wird im Rahmen des Projekts “Biotechnological Concepts for High Performance Wissenschaftsdatenbank Firmendatenbank Downloads DE EN |

Wissenschaftsdatenbank Firmendatenbank Downloads DE EN Ingredients - HiPerIn” durch CLIB2021 organisiert. | Show Details

RWI4, Düsseldorf 04 Konversationen

13. Juli Marktchancen Japan / Südkorea aquila biolabs GmbH Japan und Süd-Korea sind wichtige Absatzmärkte und Investitionsstandorte für die deutsche 2017 Baesweiler, North Rhine-Westphalia, Germany Industrie. Insbesondere im Bereich der Gesundheitswirtschaft tun sich für NRW-Unternehmen große Chancen auf. Main Sector Description ZENIT GmbH, Mülheim an der Ruhr 09 Konversationen Supplier & Engineering aquila biolabs is a German technology company that focuses on the development of laboratory devices for Subsector the analysis of shake-ﬂ ask • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, Alle Veranstaltungen biotechnological and chemical research to better understand, optimize and control their bioprocesses.

Show Details Wissen Unsere Datenbanken

aquila biolabs GmbH Baesweiler, North Rhine-Westphalia, Germany

Main Sector Description Supplier & Engineering aquila biolabs is a German technology company that focuses on the development of laboratory devices for Subsector the analysis of shake-ﬂ ask Biotech-Unternehmen • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, in Nordrhein-Westfalen biotechnological and chemical research to better understand, optimize and control their Firmenname bioprocesses.

Show Details Erweiterte Suche

BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der Life Science und Biotechnologiefirmen aus Nordrhein-Westfalen Life Science und Biotechnologiefirmen aus Nordrhein-Westfalen zur Verfügung. Die zur Verfügung. Die Information umfasst Firmenprofile, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien. Information umfasst Firmenprofile, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien.

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Durchsuchen Durchsuchen

Suchoptionen Suchoptionen

This academic database is the ﬁrst of its kind in Germany and aims to facilitate collaboration between industry and academia. The database is being launched in fall 2010 In unserem Downloadcenter ﬁnden Sie Publikationen, Vorträge und by Venture Valuation and BIO.NRW. There are currently over 1000 working groups in North Präsentationen zum Download. Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Rhine Westphalia listed. The organizations are currently in the process of up-dating and Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et complementing their data. magnis dis parturient montes, nascetur ridiculus mus.

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BIO.NRW Cluster Biotechnology … North Rhine-Westphalia

North Rhine-Westphalia is situated at Eu- dialogue between all stakeholders in the biotech developments in NRW please visit rope’s geographic and economic center. It field of biotechnology and to encourage www.bio.nrw.de. is the largest of Germany’s 16 federal states, cooperation. and the number one exporter. If classified Further drivers in the field are dynamic local as an independent exporting nation, NRW Biotech Business & Sciences biotechnology initiatives and networks: would rank 19th in the world, on a par with the BIO.NRW compiles comprehensive and Netherlands. current online databases of the academic Bioanalytik-Münster North Rhine-Westphalia’s state govern- institutions and companies active in the life www.bioanalytik-muenster.de ment has established a number of technology sciences in NRW. Free to access and easy- clusters to systematically improve NRW’s to-use, these resources are valuable tools for BioCologne strengths and talents in established industries identifying prospective business partners. www.biocologne.de and up-and-coming fields like biotechnology. More information on www.bio.nrw.de North Rhine-Westphalia’s biotechnol- bio.dortmund ogy cluster BIO.NRW is a central catalyst for Fairs, Exhibitions and Conferences www.wirtschaftsfoerderung-dortmund.de the sustainable development of the state’s Companies and academic institutions can biotech sector. It activates cooperation generate awareness of their activities locally, BioIndustry between business, research, investors and nationally and internationally by being a part www.bioindustry.de policy-makers. The cluster also promotes the of the BIO.NRW common stands on fairs, strengths and achievements of biotechnology exhibitions and conferences. BIO.NRW also BioRiver in the state. organizes a series of workshops and sympo- www.bioriver.de sia, called BIO.NRW.academy. To support young as well as already estab- LifeScienceNet Düsseldorf lished biotech companies, BIO.NRW offers Support of Young Professionals www.lifescience-dus.de the following core competencies: BIO.NRW takes a special interest in support- – Individual matchmaking for collabora- ing young professionals in biotechnology. MedLife (Aachen) tions and partners We participate in conventions and exhibi- www.medlife-ev.de – Overview on all up-to-date R&D activi- tions to bring graduates in contact with ties in industry and academia representatives from industry and academic Cluster Industrial Biotechnology – Profound knowledge on financing pos- science. The ‘Business Angel Network – BIO. www.CLIB2021.com sibilities NRW’ helps financing and funding biotech – International promotion and marketing start-ups. In addition, a forum that brings for NRW as biotech location together investment institutions, private – Direct contacts to decision makers investors and business angels and develop- ers provides information about the current Our services include NRW biotech scene. These meetings are a valuable opportunity for start-up companies Technology Transfer to receive coaching and financing. Tech transfer support is a key contribution from BIO.NRW. We organize events, work- To learn more about the Cluster BIO.NRW ing platforms and meetings to promote the and to stay informed about the latest

72 Denmark BIO.NRW

Kiel Hamburg

Bremen Schwerin Netherland Berlin Poland

Magdeburg

Hannover Potsdam

j Düsseldorf

Dresden Belgium Erfurt Frankfurt

Luxembourg Mainz Czech Republic

Saarbrücken

Stuttgart

France München Austria

Switzerland 73 BIO.NRW

Glossary

Organisation for Economic Other biotechnologically active Contact BIO.NRW Co-operation and Development companies (OECD) Dr. rer. nat. Nils Schrader … firms that apply biotechnology techniques Head of office BIO.NRW The OECD is a unique forum where the gov- for the purpose of implementing new or sig- Merowingerplatz 1 ernments of 30 democracies work together nificantly improved products or processes. 40225 Düsseldorf, Germany to address the economic, social and environ- This definition excludes end users that Fon +49 211 385469-9203 mental challenges of globalisation. innovate simply by using biotechnol - Fax +49 211 385469-9220 The OECD Biotechnology Statistics, which ogy products as intermediate inputs (for [email protected] brings together the latest available economic instance, detergent manufacturers that www.bio.nrw.de and activity data on biotechnology and in- change a formulation to include enzymes novation, is collected by OECD member and produced by other firms via biotechnology Sources, Literature, Links non-member countries. techniques). The report builds on the extensive work [1] www.nrwinvest.com/en/home/ [2] www.it.nrw/aus-und-einfuhr-2006-2016-2095 of the OECD and national experts to im - Business Areas of Activity [3] www.statistik-bw.de/VGRdL/tbls/tab. prove the comparability of biotechnology jsp?rev=RV2014&tbl=tab01&lang=de-DE statistics. – Health/Medicine [4] https://webshop.it.nrw.de/details. www.oecd.org (including animal health) php?id=21825&id2=21832 Development of therapeutics and/or diag- [5] www.duisport.de/hafeninformation/ nostics for the field of human medicine, drug [6] KPMG - Deutscher Startup Monitor 2018. delivery, human tissue replacement. Neue Signale, klare Ziele OECD Definitions [7] Analysis by BIO.NRW – Agri/Agrobiotechnology [8] www.destatis.de/DE/Startseite.html [9] Bio based Industries Consortium – Strategic Biotech focussed on genetically modified Innovation & Research Agenda; May 2017 Biotechnology company plants, animals or microorganisms, as well [10] OECD Biotechnology Statistics 2009, B. van as non-genetically modified plants grown Beuzekom and A. Arundel … is defined as a application of science and using biotechnological procedures for use in [11] NRW PCT Biotech Patent Analysis by BIO. technology to living organisms, as well as agriculture or forestry. NRW parts, products and models thereof, to alter [12] Statista living or non-living materials for the produc- – Industrial biotechnology [13] Ernst & Young 2018 Sprung nach vorne! Modell Deutschland: Von der Biologie zur tion of knowledge, goods and services. Biotechnological products and processes for Innovation. 20 Jahre Deutscher Biotechno- the handling of waste or sewage, for chemical logie-Report Dedicated biotechnology synthesis, for the extraction of raw materials [14] http://data.worldbank.org/indicator/ companies and energy, etc. GB.XPD.RSDV.GD.ZS [15] www.biotechgate.com; Venture Valuation, … are defined as biotechnology active firms – Non-specific application Zurich, CH [16] BCG und vfa bio 2018 Biotech-Report. whose predominant activities involve the Equipment or reagents based on biotechno- Medizinische Biotechnologie in Deutschland application of biotechnology techniques to logical principles for research or provision of 2018; www.vfa-bio.de produce goods or services and/or the per- services in this field (“ancillary industry”). [17] www.leitmarktagentur.nrw/ formance of biotechnology R&D. Source: biotechnologie.de leitmarktwettbewerbe/lifesciences

Online Company Company Database Directory www.bio.nrw.de

BIO.NRW Merowingerplatz 1 40225 Düsseldorf,Duesseldorf Germany Germany Fon +49 211 385469-9200 Fon + 49 (0) 2 11 385 469 - 9200 Fax +49 211 385469-9220 Fax + 49 (0) 2 11 385 469 - 9220 [email protected] www.bio.nrw.de

Ministry of EconomicInnovation, Affairs, Science, Innovation, DigitizationResearch and and Technology Energy of ofthe the State ofState North of NorthRhine-Westphalia Rhine-Westphalia 4021340221 DüsseldorfDuesseldorf www.innovation.nrw.de www.wirtschaft.nrw www.exzellenz.nrw.de ‘Excellence NRW’ stands for the cluster strategy in North Rhine-Westphalia, an innovative location for business. The state government www.bio.nrw.de Spot on Biotechnology Business 2019 there wants to improve on its strengths, and systematically strive for excellence in NRW. The goal of the cluster policy is to create an environment that is friendly to innovation, strengthens the competitive edge of the businesses there, and stimulates growth and employment. To find out more about NRW’s cluster strategy and the 16 clusters in the state, just visit: www.exzellenz.nrw.de