DOCSLIB.ORG

Lipid Lowering Treatment in Mild to Moderate Aortic Stenosis Thesis for the Degree of Philosophiae Doctor (Phd)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Lipid Lowering Treatment in Mild to Moderate Aortic Stenosis Thesis for the Degree of Philosophiae Doctor (Phd) FACULTY OF MEDICINE, UNIVERSITY OF OSLO, AND DEPARTMENT OF CARDIOLOGY, OSLO UNIVERSITY HOSPITAL, AKER AND ULLEVÅL, OSLO, NORWAY 2015 Lipid Lowering Treatment in Mild to Moderate Aortic Stenosis Thesis for the Degree of philosophiae doctor (PhD) Anne Bjørhovde Rossebø December 2015 1 Thesis 2015. Anne Bjørhovde Rossebø © Anne Bjørhovde Rossebø, 2016 Series of dissertations submitted to the Faculty of Medicine, University of Oslo ISBN 978-82-8333-245-2 All rights reserved. No part of this publication may be reproduced or transmitted, in any form or by any means, without permission. Cover: Hanne Baadsgaard Utigard Printed in Norway: 07 Media AS – www.07.no CONTENTS ACKNOWLEDGEMENTS ........................................................................................................... 4 LIST OF PAPERS .......................................................................................................................... 7 Paper I .......................................................................................................................................... 7 Paper II......................................................................................................................................... 7 Paper III ....................................................................................................................................... 7 Paper IV ....................................................................................................................................... 7 ABBREVIATIONS ........................................................................................................................ 8 INTRODUCTION ........................................................................................................................ 10 Etiology ..................................................................................................................................... 13 Risk factors............................................................................................................................ 13 Histopathology ...................................................................................................................... 20 Pharmacologic intervention for AS? ................................................................................... 20 Left ventricle hypertrophy.................................................................................................... 21 AIMS OF THE STUDY ............................................................................................................... 22 Hypothesis ................................................................................................................................. 22 General aims .............................................................................................................................. 23 Specific aims ............................................................................................................................. 23 METHODS .................................................................................................................................... 25 Pilot study at Aker University Hospital 1995-97 .................................................................... 25 Main study design and organization ........................................................................................ 28 Study population ....................................................................................................................... 30 Echocardiography ..................................................................................................................... 35 Study treatment ......................................................................................................................... 36 Simvastatin ............................................................................................................................ 37 Ezetimibe ............................................................................................................................... 37 Study treatment safety .......................................................................................................... 38 Study endpoints ......................................................................................................................... 39 Statistical analysis ..................................................................................................................... 41 SUMMARY OF THE RESULTS ................................................................................................ 45 Paper I ........................................................................................................................................ 45 Paper II....................................................................................................................................... 46 Paper III ..................................................................................................................................... 48 Paper IV ..................................................................................................................................... 49 2 Thesis 2015. Anne Bjørhovde Rossebø DISCUSSION ............................................................................................................................... 51 Mild to moderate aortic stenosis .............................................................................................. 51 Lipid lowering therapy in aortic stenosis ................................................................................ 54 Role of left ventricular hypertrophy ........................................................................................ 58 Sudden cardiac death ................................................................................................................ 60 Limitations................................................................................................................................. 61 Future perspectives ................................................................................................................... 62 CONCLUSIONS ........................................................................................................................... 64 REFERENCE LIST ...................................................................................................................... 66 PAPER I-IV…………………………………………………………………………………. 3 Thesis 2015. Anne Bjørhovde Rossebø ACKNOWLEDGEMENTS The present work is based on clinical studies carried out while based at the Division of Cardiology, Aker University Hospital, Oslo, though this hospital was re-organized and closed down ending 2011 as part of a large hospital ‘merger’ in the capital of Norway. Since 2010 my workplace has been at the Department of Cardiology, Oslo University Hospital, Ullevål. The studies were carried out between 1997 and 2010, with the most active phase 2001-2008. The studies were funded by Kardiologisk Forskningsfond, Aker University Hospital February-March 1998; research grant from MSD Norway 1998-2002; research grant as well as funding of the main study from MSP Singapore Company, LLC, Singapore (a partnership between Merck Sharp and Dohme and Shering Plough) 2003-2008; and a PhD research fellow scholarship from South-Eastern Norway Regional Health Authority 2008-2010. First and foremost I would express my gratitude to Professor Terje R. Pedersen at Oslo University Hospital, Ullevål, who has been my principal advisor during the whole process. He introduced me to research in my very early years of internal medicine and cardiology at Aker University Hospital. I will forever have great respect for this international capacity within lipidology and preventive cardiology, who conveyed with scientific clarity, but also sincere kindness, his great knowledge about clinical research. I am indebted to him for including me into his vast international research network, from which my own network could grow. Through our long lasting collaboration I have learnt that planning, getting funding and not the least execution of large multicenter studies more than anything needs patience and endurance in phases of ups and downs. I am grateful for his ‘never ever give up’-attitude which allowed me, despite the unintentional extended time frame, to complete my cardiology training and be a family person along with research. My second advisor, Professor Dan Atar, previous head of the Cardiology Departments at Aker and Ullevål hospitals, has inspired with his dynamic and ever-optimistic attitude to research. 4 Thesis 2015. Anne Bjørhovde Rossebø I will always be grateful to my previous colleges at the Division of Cardiology Aker University Hospital, where the “conception and birth” and actual work of my research took place. A special thanks to my seniors drs Kjetil Steine and Tone Nerdrum, who with good-humored influence and clinical clarity taught me my basic cardiological skills and introduced me to echocardiography and remained inspiring and positive throughout the Aker years. Furthermore I thank study nurse Hege Claussen, for experienced practical research management since the early start of the study as well as for lending an ear to frustrated research fellows every now and then. I will also thank all study patients I have had the pleasure to know personally through many years. To my distinguished colleges collaborating in the SEAS Steering Committee I will always
Load more

Recommended publications
  • The Letters of Marcus Tullius Cicero to Several of His Friends
    UC SOUTHERN REGIONAL LIBRARY FACILITY AA 000 464 615 4 Ex Libris C. K. OGDEN w m '»? ^ .'. -vX , \ > • I LETTERTHE OF Marcus Tulliiis Cicero T O Several of his Friends: With REMARKS By W I L L I A M M E L M O T H, Efqi Quo fit ut omnis Votlva pateat veluti defcripta tabella Vita fenis. HoR. THE THIRD EDITION. IN THREE VOLUMES. VOL. III. i:x.:\/usfj{eg. 6V^//. LONDON: Printed for J. Dodsley, in Pall-mall. 177J, SRLF URl fft LETTERS.,...— , E^-nij OF Marcus Tullius Cicero T O Several of his F R i E N d So BOOK XI. LETTER L To Tiro. letter encourages me to hope that A.u.70?. find better : I am fure at YOURyou yourfelf leaftj I moil fincerely wifh that you may. I intreat you therefore to confecrate all your cares to that end ; and by no means indulge fo miftaken a fufpicion as that I am difpleafed you are not with me. With me you are, in the bell fenfe of that exprelTion, if you are tak- ing care of your health : which I had much rather you Ihouid attend^ than on myfelf. For Vol. UI. B tho' 2 The letters Book XL .v.u.7o8.tho'' I always both fee and hear you with plea- lure that will j pleafure be greatly increafed, when I fhali have the fatisfaftiory at the fame tii-n* to be afiured that you are perfectly well. My work is at prefcnt fufpended \ as I can- not make ufe of my own hand: however I em- ploy myfclf a good deal in reading.
    [Show full text]
  • The History of the Celtic Language May Be Turned To
    '^^'& msw 6iW. l(o?^ )^. HISTORY CELTIC LANGUAGE; WHEKEIX IT IS SHOWN TO BE BASED UPON NATURAL PRINCIPLES, AXD, ELEMENTARILY CONSIDERED, CONTEMPORANEOUS WITH THE INFANCY OF THE HUMAN FAMILY : LIZEWISE SHOWING ITS IMPORTANCE IN ORDER TO THE PROPER UNDERSTANDING OF THE CLASSICS, INCLUDING THE SACRED TEXT, THE HIEROGLYPHICS, THE CABALA, ETC. ETC. BY L. MACLEAN, F.O.S, kuthnr of" Historical Account of lona," " Sketches of St Kilda," &c. Sec. LONDON: SMITH, ELDER, and CO.; EDINBURGH: M'LACHLAN, STEWART, and CO. GLASGOW: DUGALD MOORE. MDCCCXL. " IT CONTAINS MANY TRUTHS WHICH ARE ASTOUNDING, AND AT WHICH THE IGNORANT MAY SNEER; BUT THAT WILL NOT TAKE PROM THEIR ACCURACY. "_SEB SIR WILLIAM BETHAM's LETTER TO THE AUTHOR IN REFERENCE TO THE GAELIC EDITION. " WORDS ARE THE DAUGHTERS OF EARTH—THINGS ARE THE SONS OF HEAVEN."—SAMUEL JOHNSON, GLASGOW: — F.nWAKi) KHII.I., I'Hl NTER TO THE U M VERSITV. ^' D IBtKication^ RIGHT HONOURABLE SIR ROBERT PEEL, baronet, m.p. Sir, An ardent admirer of your character, public and private, I feel proud of the permission you have kindly granted me to Dedicate to you this humble Work. The highest and most noble privilege of great men is the opportunity their station affords them of fostering the Fine Arts, and amplifying the boundaries of useful knowledge. That this spirit animates your bosom, each successive day is adding proof: nor is the fact IV DEDICATION. unknown, that whilst your breast glows with the fire of the patriot, beautifully harmonizing with the taste of the scholar, your energies are likewise engaged on the side of that pure religion of your fathers, with which your own mind has been so early imbued, and which, joined with Education, is, as has properly been said, " the cheapest defence of a nation;" as it is the only solid foundation whereon to build our hopes of bliss in a world to come.
    [Show full text]
  • Studies in Tennyson Poems of Tennyson
    1920. COPTBIGHT, 1889. 1891. 1892. 1897, 1898. BY CHARLES SCRIBNEB's SONS Published February, 1920 PR. 558% V4 THE 8CRBNER PRESS BY HENRY VAN DYKE The Valley of Vision Fighting for Peace The Unknown Quantity The Ruling Passion The Blue Flower Out-of-Doors in the Holy Land Days Off Little Rivers Fisherman's Luck Poems, Collection in one volume Golden Stars The Red Flower The Grand Canyon, and Other Poems The White Bees, and Other Poems The Builders, and Other Poems Music, and Other Poems The Toiling of Felix, and Other Poems The House of Rimmon Studies in Tennyson Poems of Tennyson CHARLES SCRIBNER'S SONS STUDIES IN TENNYSON <J / A YOUNG WOMAN OF AN OLD FASHION WHO LOVES ABT NOT ONLY FOE ITS OWN SAKE BUT BECAUSE IT ENNOBLES LIFE WHO READS POETRY NOT TO KILL TIME BUT TO FILL IT WITH BEAUTIFUL THOUGHTS AND WHO STILL BELIEVES IN GOD AND DUTY AND IMMORTAL LOVE I DEDICATE THIS BOOK PREFACE 1 HIS volume is intended to be a companion to my Select Poems of Tennyson. I have put it second in the pair because that is its right place. Criticisms, com^ ments, interpretations, are of comparatively little use until you have read the poetry of which they treat. Like photographs of places that one has not seen, they lack the reviving, realizing touch of remembrance. The book contains a series of essays, written at dif- ferent times, printed separately in different places, and collected, substantially, in a book called The Poetry of Tennyson, which was fortunate enough to find many friends, and has now, I believe, gone out of print.
    [Show full text]
  • Fishes of the Philippine Islands
    FISHES OF THE PIDLIPPINE ISLANDS. By BARTON WARREN EVERMANN. A. M••Ph.D••and ALVIN SEALE. A. B. BUREAU OF FISHERIES DOCUMENT NO. 607. B. B. F. i906-4 49 Blank page retained for pagination FISHES OF THE PHILIPPINE ISLANDS. By BARTON WARREN EVERMANN, A. M., PH. D., AND ALVIN SEAJ~E, A. B. Among the exhibits made by the U. S. Bureau of Insular Affairs at the Lou­ isiana Purchase Exposition, held at St. Louis, Missouri, during the summer and fall of 1904, was a considerable collection of fishes from the Philippine Islands. This collection had been made under the direction of the Philippine government for the specific purpose mentioned. At the close of the exposition the authorities turned the entire collection over.to the U. S. Bureau of Fisheries for study and report. The localities represented in the collection are as follows: San Fabian, Pangasinan, Luzon.~San Fabian is situated on the Gulf of Lin­ gayen, about 100 miles north of Manila. The collection from this place was made by Mr. C. L. Hall and is a-large and important one. Bacon, Sorsoqon, Luzon.-Sorsogon is the most southern province of Luzon. Bacon is situated in the northern part of the province, on Albay Inlet, in approxi- mately latitude 130 3' north and longitude 1240 east. Bulan, Sorsogon, Luzon.-Bulan is on the west coast of Sorsogon, near the southern end of the province, approximately in latitude 120 38' north, longitude 1230 22' east. The collections from Bacon and Bulan are more extensive than any of the others.
    [Show full text]
  • Plainheld 12 Pages Nrs.Sperry Is 96
    {FEATHER FORECAST March K. 1*17 12 PAGES Ttr»IUr toalshttonigh! anaand Suaday.Sund V- KKMPBRATCRB IN WHICH IS MERGED THE AVKRAfif!LVKHAKK DAILYDAILY CIRCU-I'llll C- k LATIONLATION LASTLAST WEEKWEKK IdaBigbet**<t yaslardayyesterday . ..51*6 bowertLowest thisthis mommornin leag .....41..43 PLAINHELPLAINFIELDD DAILY PRESS, 7,787,7899 I’LIIM!•!. IliniU IEUI,l JEIKWW JKRHKY.JKKSKV. UI11UIAT,MI1HIUI, MARCHJHBtH MM,, 1917J»1T.. PRICEPRICE TWOTWO CENTSOEHTS DR.STR0NGTO SPEAK C. A. STEINER NRS.SPERRHRS. SPERRYY HUMARUHANN SIDSIDEE OFOF DR. STRONGTO SPEAK C. A. STEINER CHURCCHURCHH SOCIETYSOCIETY MYSTERIOUMYSTERIOUSS pANOEUVRINMANOEUVRINGG OFFOFF FOFORR JEWISHJEWISH RELIEFRELIEF DIEDIESS ININ WESTWEST 25 YEARS OLD B 96 YEARS OLD TRENCTRENCHH WAWARR 25 YEARS OLD IS 96 YEARS OLD T~j— 1 • tHEM/||sAGBUSETTtHE MASSACHUSETTSS COASCOASTT WifWilll AddresiAddress thethe MeetinMeetingg iinn Jiforme r LocalLocal ResidenResidentt Ladies’ Aid Society of Bor- BByy UnitedUnited fresspress:: >’ i ~~^ Colombo*Columbus AuditoriumAuditorium oonn Fasses Away at Banning, Ladiesough' AiChorchd Societ Heldy Birtb-of Bor - Afed Borough Woman Cele- Captain Ian Hay Beilh Ad- Passes Away at Banning, Aged Borough W»nun Cele- Csptein Ian Hay Beith Ad- ApriAprill 33dd ough Church Held Birth- NewNew Bedford.Bedford, MarchM$j3l 24.—Mysteriou24 — Mysteriouss manoeuvring brates Event at Home of dressed Big Audience Under CaL—FuneralCaL—Funeral HereHere day Party by the watbr-front poltce, and- investigations of Brandt's bntet Event at Home of irtnei Big Audience Under Dr Philip D. Strong. of tb# Pint Word of iha daath or durl Alban '■ Tha birthdayday Partparly y cl--a la Daughter,Daughter, Mr*.Mrs. Steren*Stevens National Special Aid Baptist Church, ha*. —oonaented to.... Stainer. a(a 30 year.
    [Show full text]
  • Journal of Roman Studies Roman Inscriptions 2006–2010
    Journal of Roman Studies http://journals.cambridge.org/JRS Additional services for Journal of Roman Studies: Email alerts: Click here Subscriptions: Click here Commercial reprints: Click here Terms of use : Click here Roman Inscriptions 2006–2010 Alison E. Cooley and Benet Salway Journal of Roman Studies / Volume 102 / November 2012, pp 172 ­ 286 DOI: 10.1017/S0075435812001074, Published online: 01 October 2012 Link to this article: http://journals.cambridge.org/abstract_S0075435812001074 How to cite this article: Alison E. Cooley and Benet Salway (2012). Roman Inscriptions 2006–2010. Journal of Roman Studies, 102, pp 172­286 doi:10.1017/S0075435812001074 Request Permissions : Click here Downloaded from http://journals.cambridge.org/JRS, IP address: 144.82.107.89 on 05 Nov 2012 SURVEY ARTICLE Roman Inscriptions 2006–2010 ALISON E. COOLEY AND BENET SALWAY IGENERAL I.i General Introduction The aim of this quinquennial survey remains the same as its predecessor, as for the most part does the format, though the team is regrettably reduced by one.1 With an eye to the study of the Roman world, we hope to signal the most important newly published inscriptions, signicant reinterpretations of previously published material, new trends in scholarship, recent studies that draw heavily on epigraphic sources, and noteworthy developments in the various aids to understanding inscriptions (both traditional printed material and electronic resources). In the context of this journal, the geographical range and chronological scope reect the contours and history of the Roman state from its beginnings down to the end of the seventh century. As such, not only does the survey naturally take in Greek as well as Latin texts, but also epigraphic material in other languages relevant to the Roman world.
    [Show full text]
  • ATLAS of CLASSICAL HISTORY
    ATLAS of CLASSICAL HISTORY EDITED BY RICHARD J.A.TALBERT London and New York First published 1985 by Croom Helm Ltd Routledge is an imprint of the Taylor & Francis Group This edition published in the Taylor & Francis e-Library, 2003. © 1985 Richard J.A.Talbert and contributors All rights reserved. No part of this book may be reprinted or reproduced or utilized in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. British Library Cataloguing in Publication Data Atlas of classical history. 1. History, Ancient—Maps I. Talbert, Richard J.A. 911.3 G3201.S2 ISBN 0-203-40535-8 Master e-book ISBN ISBN 0-203-71359-1 (Adobe eReader Format) ISBN 0-415-03463-9 (pbk) Library of Congress Cataloguing in Publication Data Also available CONTENTS Preface v Northern Greece, Macedonia and Thrace 32 Contributors vi The Eastern Aegean and the Asia Minor Equivalent Measurements vi Hinterland 33 Attica 34–5, 181 Maps: map and text page reference placed first, Classical Athens 35–6, 181 further reading reference second Roman Athens 35–6, 181 Halicarnassus 36, 181 The Mediterranean World: Physical 1 Miletus 37, 181 The Aegean in the Bronze Age 2–5, 179 Priene 37, 181 Troy 3, 179 Greek Sicily 38–9, 181 Knossos 3, 179 Syracuse 39, 181 Minoan Crete 4–5, 179 Akragas 40, 181 Mycenae 5, 179 Cyrene 40, 182 Mycenaean Greece 4–6, 179 Olympia 41, 182 Mainland Greece in the Homeric Poems 7–8, Greek Dialects c.
    [Show full text]
  • Map 87 Pontus-Phasis Compiled by David Braund and T
    Map 87 Pontus-Phasis Compiled by David Braund and T. Sinclair (Turkey), 1997 with the assistance of Diane Braund Introduction Pontus The land of Pontus has two main parts, both of which belonged to the Mithridatic kingdom of Pontus in the Hellenistic period. The first is the main ridge of the Pontic mountains and the steep descent to the shore. The lower slopes are thickly wooded, and the shore districts have a humid and rainy climate. In the main Pontic ridge a gap occurs in the hinterland of Amisus (modern Samsun), after which the mountain chain continues at a lower height and with less abrupt slopes (Strabo’s term Paryadres seems to denote the higher part of the chain). As far east as Rhizaion (Rize) Greek settlements along the coast have existed since the sixth century B.C., and in the case of Sinope the seventh. To the south, the Pontic chain is bordered by Armenia Minor, a part of Armenia itself (Late Antique Sper, probably the Syspiritis of the classical authors), and what was to become the Georgian mountainous district of Tao, drained by the R. Glaukos (Oltu Çay) and the Tortum Çay. The district of Chaldia, the Gümüşhane basin, is difficult to classify, particularly in classical times, as there is no evidence that it belonged either to Pontus (in a geographical or administrative sense), to Armenia Minor, or to Armenia itself. The Roman empire made no effort to control the interior of Chaldia until the reign of Justinian. The second part of Pontus is the series of fertile inland plains, joined by relatively low chains of hills, in the river systems of the Iris (Kızıl Irmak) and the lower Halys (Yeşil Irmak).
    [Show full text]
  • 1 SATIRE in the HISTORIA AUGUSTA by SHAWN GAIUS
    SATIRE IN THE HISTORIA AUGUSTA By SHAWN GAIUS DANIELS A DISSERTATION PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY UNIVERSITY OF FLORIDA 2013 1 © 2013 Shawn Gaius Daniels 2 Matri meae 3 ACKNOWLEDGMENTS First, I would like to thank my advisor, Dr. Victoria Pagán. When I began to read the Historia Augusta in the Summer of 2010, I was struck most by its humor. Dr. Pagán recommended that I turn to Northrop Frye and his Anatomy of Criticism to find a theoretical basis on which to understand the role of humor, and it is there that I found a definition of satire that took me on the road to the present work. A large portion of the bibliography and the majority of the organizational structure came from the many conversations we held over the past three years. Without her unflagging support and invaluable advice, this project would not have been completed. I owe many thanks to Dr. Trevor Luke, of Florida State University. He found time, even at conferences, to speak with me individually about my research—once even driving down from Tallahassee to discuss a rough draft he had read the week before. His penetrating questions and moral support have kept me critical of my own work. I would also like to thank the other members of my committee, Dr. Andrew Wolpert, Dr. Kostas Kapparis, and Dr. Terry Harpold for sparing their time to help see that I accomplish this task. I would like to thank several former teachers and professors for helping bring me to this point.
    [Show full text]
  • Virtue from Necessity in the Urban Waterworks of Roman Asia Minor
    UNIVERSITY OF CALIFORNIA Santa Barbara Virtue from Necessity in the Urban Waterworks of Roman Asia Minor A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in History of Art and Architecture by Brianna Lynn Bricker Committee in charge: Professor Fikret K. Yegül, Chair Professor Swati Chattopadhyay Professor Christine M. Thomas June 2016 The dissertation of Brianna Lynn Bricker is approved: ____________________________________________ Swati Chattopadhyay ____________________________________________ Christine M. Thomas ____________________________________________ Fikret K. Yegül, Committee Chair June 2016 ACKNOWLEDGEMENTS Damlaya damlaya göl olur “Drop by drop, a lake will form,” goes the Turkish proverb. And so went this dissertation project: little by little quotidian efforts turned into something larger. But these drops, in fact, were not just my own efforts, nor were they always quotidian. The number of drops contributed by others is incalculable, but the impact is clear. Special thanks go to my advisor Fikret Yegül for his unwavering support and kindness throughout my graduate school experience. I also thank Diane Favro for her continual warmth and helpfulness. I am deeply thankful for my other committee members, Swati Chattopadhyay and Christine Thomas, for providing important outside perspectives and challenging me to go farther with my work. I am truly grateful for my community at UCSB: firstly, the Department of the History of Art and Architecture, for the support and space to grow as a scholar. I also thank the Ancient Borderlands Research Focus Group for fostering collaboration between disciplines and creating an inviting and dynamic atmosphere of research. I would particularly like to thank my community at the Sardis Expedition, for nurturing in me the curiosity and zeal to explore the Anatolian countryside: Marcus Rautman introduced me to the intricacies and interesting nature of waterworks, while Bahadır Yıldırım and Nicholas Cahill provided further encouragement and perspective.
    [Show full text]
  • Roman Roads Reader: Drama and Lyric
    Roman Roads Reader: Drama and Lyric Selections from Greek Drama & Lyric Companion Book for Greeks: Drama and Lyric, a video course by Roman Roads Media. Euripides, Sappho, Pindar, Hesiod, Theocritus, Quintus of Smyrna, and Apollonius of Rhodes Edited by Daniel Foucachon This book has been designed to accompany the video course Greeks: Drama and Lyric, part of the Old Western Culture series by Roman Roads Media. To find out more about this course, visit www.romanroadsmedia.com While the selections contained in this volume match the specific course of study for Drama and Lyric (mentioned above), this selection may be of great use and enjoyment to any student of the classics, and we hope it finds its way into your library. Other titles in the Old Western Culture Series by Roman Roads Media: Greeks: -- The Epics (The Iliad & The Odyssey) -- Drama and Lyric (The Tragedies, Comedies, and Minor Poets) -- The Histories (Herodotus, Thucydides, and Xenophon) -- The Philosophers (Plato and Aristotle) Romans: -- The Roman Epic (The Aeneid, Ovid, and Lucretius) -- The Historians (Livy, Tacitus, Salust, Julius Caesar, Plutarch, and Cicero) -- Early Christianity (Clementine, Ignatius, Irenaeus, Justin Martyr, and Eusebius) -- Post-Nicene Christianity (Athanasius, Augustine, and Boethius) Christendom: -- Early Medieval (St. Benedict, Bede, Charlemagne, and Alfred the Great) -- The Defense of the Faith (Anselm, Geffrey of Monmoth, The Golden Legend) -- The Medieval Mind (Dante and Aquinas) -- The Reformation (Erasmus, Calvin, Cranmer, Spencer, and Chaucer)
    [Show full text]
  • NOT CHEAPEST, but LEAST EXPENSIVE \ MODERN PLUMBING and HEATING HAND NAMED to SUCCEED SENATOR LEWIS M. CRES5E Tin, • Slate
    THE FACE ON THE j admiringly on toe tine, wtmo parting .- . •« that'.«cr>ara|ed' tho braids of purest WAIiTZ OP THE GIGLI HOW FAKE COME8. It Is.Wot thai or aa India., ^.j flax.. • ' •.'•• ' * • . Prellr Utlto Hutj^.^l THE ."Ami bow d"jro Ilko them, Mr. Sel- 100 00 Mrs. Barali Longncre : THE STRANGEST, MADDEST DANCE 1(1 IOV0I. dcnr* naked Mm. Jono* a bit later, re- DUB' 10 NOTICE Is ornbv fiwn by NICHOLAS C0R8OV, Col- ed and., died In PbUudelpha{<«!' rcrctng to tlu> biscuit , .. *.'.,,.. THE WORLD. : | Accident" has ployed an Important « tecbir of fmxm of UM Vtty ol Ucemn Cli», C»I" M«y Couoly. New •.,,100 00 -LILACS : Mit hi the m«h|i»(r of great men. If itntr. that by Tlrtua of tb« ataluM In incb o«w m-da «nil pro»l<»<). ncarefbclnit the upeeu of tSr'- "I love thorn.", n iw wened ho, .referring. be will Mil »t'pabllcL«l« all I'm laoda,lananianl>,liar«lllanMnU So ui~ •tot cau mWt jthiit., any n-ooian w Cooper had never been challenged by anda realraal catatnl«l*b<ral* baralnD CM'' m roentl>)Da<l,manll.ioad,orTlne . r p«rl tliarwiraulBclant ^ • tbo'Elri' dlmppl ( *a»t Ptaigtaalto au»d Diagaiou tor Ibe pprpoae lo pay Ibaa ta tax liell«n iberrooinerroo,. fortorlh. iba year iw1908n, Inelad- UoBthJersfyltaco. IWOO tw sot lived, with tbo exo.-ptlon of ; his wife to. wrlto as eood a story as' •zut Wants. • Of coaiw that wn« only'the bosln- liiro ol Ibe Uamarkabla mnttval of ln( intonaf and coats of sale orlklH, wherbsme no,onno onee will bid far • IWOO j jo Victoria, wliow Imngo was tj£ an EnsUsb novel bo bad.been roadtag aboriar term.
    [Show full text]