bioRxiv preprint doi: https://doi.org/10.1101/2020.11.08.373225; this version posted November 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Genomic Insights into the Demographic History of Southern Chinese Xiufeng Huang1,#, Zi-Yang Xia2,3,4,#*, Xiaoyun Bin1,#, Guanglin He2, Jianxin Guo2, Chaowen Lin1, Lianfei Yin1, Jing Zhao2, Zhuofei Ma1, Fuwei Ma1, Yingxiang Li2, Rong Hu2, Lan-Hai Wei2, Chuan-Chao Wang2,* 1. College of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China 2. Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, and National Institute for Data Science in Health and Medicine, School of Life Sciences, Xiamen University, Xiamen 361005, China 3. Division of Biosciences, University College London, London WC1E 6BT, United Kingdom 4. Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China # These authors contributed equally to this work. * Corresponding author: Professor Chuan-Chao Wang (
[email protected]) and Zi-Yang Xia (
[email protected]). ABSTRACT Southern China is the birthplace of rice-cultivating agriculture, different language families, and human migrations that facilitated these cultural diffusions. The fine-scale demographic history in situ, however, remains unclear. To comprehensively cover the genetic diversity in East and Southeast Asia, we generated genome-wide SNP data from 211 present-day Southern Chinese and co-analyzed them with more than 1,200 ancient and modern genomes.