Interactions with PBC Agents

www.hep-druginteractions.org

Charts created March 2020. Full information available at www.hep-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Anaesthetics & Muscle Relaxants Antibacterials (continued) Antidepressants Bupivacaine   Cloxacillin   Agomelatine  Cisatracurium   Dapsone   Amitriptyline  Isoflurane   Delamanid   Bupropion   Ketamine   Ertapenem   Citalopram   Nitrous oxide   Erythromycin   Clomipramine  Propofol   Ethambutol   Desipramine  Thiopental   Flucloxacillin   Desvenlafaxine  

Tizanidine  Gentamicin   Dosulepin  Analgesics Imipenem   Doxepin  Aceclofenac   Isoniazid  Duloxetine   Alfentanil   Escitalopram   Aspirin   Levofloxacin   Linezolid  Fluoxetine   Buprenorphine   Fluvoxamine   Lymecycline   distribution. Celecoxib   Imipramine  Meropenem   Codeine  Lithium   Methenamine   Dexketoprofen   Maprotiline  Metronidazole   Dextropropoxyphene  Mianserin   Moxifloxacin   Diamorphine  Milnacipran   Diclofenac   Nitrofurantoin  

only. Not for distribution. for only. Not Mirtazapine  Diflunisal   Norfloxacin   Moclobemide   Dihydrocodeine  Ofloxacin   Nefazodone   Etoricoxib  Penicillin V   Nortriptyline  Fentanyl   Piperacillin   Paroxetine   Flurbiprofen   Pivmecillinam   Sertraline  

Hydrocodone  use ersonal Pyrazinamide   Tianeptine   Hydromorphone  Rifabutin Trazodone   Ibuprofen   Rifampicin Indometacin  Trimipramine  Rifapentine  Ketoprofen   Venlafaxine   Rifaximin  Mefenamic acid   Vortioxetine   Meloxicam  Spectinomycin   Antidiabetics Metamizole (Dipyrone)   Streptomycin   Acarbose   Methadone  Sulfadiazine   Albiglutide   Morphine   Tazobactam   Alogliptin   Naproxen   Telithromycin   Canagliflozin  

Oxycodone  Temocillin   for Not only. use For personal for distribution. Dapagliflozin   Paracetamol   Tetracyclines   Dulaglutide   Pethidine (Meperidine)  Ticarcillin   Empagliflozin   Piroxicam   Trimethoprim/Sulfamethoxazole   Exenatide   Tapentadol  Troleandomycin   Glibenclamide (Glyburide)  Tramadol  Vancomycin   Gliclazide   Anthelmintics Anticoagulant, Antiplatelet & Fibrinolytic Glimepiride  Albendazole   Acenocoumarol Glipizide  Ivermectin   Anagrelide Insulin   Oxamniquine   Apixaban  Linagliptin   Praziquantel  Clopidogrel  Liraglutide   Pyrantel   For p for distribution. Not only. use r personal Dabigatran  Lixisenatide   Antiarrhythmics Dalteparin   Metformin   Amiodarone Danaparoid   Nateglinide   Bepridil  Dipyridamole   Pioglitazone  Digoxin   Edoxaban  Repaglinide  Disopyramide   Eltrombopag    Dofetilide  Enoxaparin   Rosiglitazone  Dronedarone Fluindione Saxagliptin   Flecainide  Fondaparinux   Sitagliptin   Lidocaine (Lignocaine)   Heparin   Tolbutamide  Mexiletine  Phenprocoumon  Vildagliptin   Propafenone  Prasugrel   Antifungals Quinidine  Rivaroxaban  Amphotericin B   Vernakalant   Streptokinase   Anidulafungin   Antibacterials Ticagrelor   Caspofungin   Amikacin   Ticlopidine   Fluconazole   Amoxicillin   Tinzaparin   Flucytosine   Ampicillin   Warfarin  Griseofulvin   Azithromycin   Anticonvulsants Isavuconazole   Aztreonam   Carbamazepine  Itraconazole  Bedaquiline   Not only. use For personal for distribution. Not only. use personal Clonazepam   Ketoconazole  Benzylpenicillin   Eslicarbazepine   For personal use only. Not for distribution. Fo for distribution. Not only. use For personal For Miconazole   Capreomycin   Ethosuximide   Nystatin   Cefaclor   Gabapentin   Posaconazole  Cefadroxil   Lacosamide   Terbinafine   Cefalexin   Lamotrigine   Cefazolin   Levetiracetam   Voriconazole  Cefixime   Oxcarbazepine   Cefotaxime   Perampanel   Cefradine   Phenobarbital  Ceftaroline   Phenytoin  Ceftazidime   Pregabalin   Ceftriaxone   Primidone   Cefuroxime   Retigabine   Chloramphenicol   Rufinamide   Ciprofloxacin   Sultiame   Clarithromycin   Tiagabine   Clavulanic acid   Topiramate   Clindamycin  Valproate (Divalproex)   Clofazimine   Vigabatrin   Zonisamide  

Key to symbols Notes  Further information is available at © Liverpool Drug Interactions Group,  These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional  Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF  monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional  Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude  No clinically significant interaction expected  Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law.

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with PBC Agents

Charts created March 2020. Full information available at www.hep-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Antihistamines Antivirals Cancer Therapies Astemizole Aciclovir   Abiraterone   Bilastine   Amantadine   Acalabrutinib  Cetirizine   Brivudine   Anastrozole   Chlorphenamine  Cidofovir   Avelumab   Desloratadine   Foscarnet   Axitinib   Diphenhydramine   Oseltamivir   Bevacizumab   Doxylamine   Blinatumomab  

Rimantadine   Ebastine   Valaciclovir   Bortezomib   Fexofenadine   Zanamivir   Bosutinib   Hydroxyzine   Brentuximab vedotin   Anxiolytics/Hypnotics/Sedatives Levocetirizine   Capecitabine   Alprazolam   Loratadine   Carboplatin  

Amobarbital  distribution. Promethazine   Cetuximab    Bromazepam   Terfenadine Chlorambucil  Antimigraine Agents Bromperidol   Cisplatin   Almotriptan   Buspirone   Cyclophosphamide   Dihydroergotamine   Clobazam   Daratumumab   Eletriptan   Clorazepate   only. Not for distribution. for only. Not Dasatinib  

Ergotamine  Clotiapine   Doxorubicin   Frovatriptan   Diazepam   Erlotinib  Methylergonovine  Estazolam   Estramustine  Naratriptan   Flurazepam   Etoposide   Pizotifen  

ersonal use ersonal Lorazepam   Everolimus  Rizatriptan   Lormetazepam   Exemestane  Sumatriptan   Midazolam (oral)  Fludarabine   Zolmitriptan   Midazolam (parenteral)  Gefitinib   Antiprotozoals Oxazepam   Gemcitabine   Amodiaquine  Idarubicin  Artemether   Quazepam   Imatinib  Artemisinin   Temazepam   Ipilimumab   Artesunate   Triazolam   Irinotecan   Atovaquone  Zaleplon   Ixazomib   Chloroquine  Zolpidem  

Dihydroartemisinin   Zopiclone   for Not only. use For personal for distribution. Lapatinib   Letrozole   Doxycycline   Beta Blockers Medroxyprogesterone Halofantrine  Atenolol     (oncology) Hydroxychloroquine   Bisoprolol   Mercaptopurine   Lumefantrine   Carvedilol  Mesna   Mefloquine   Celiprolol  Pentamidine   Labetalol  Methotrexate   Primaquine  Metoprolol   Mitoxantrone   Proguanil   Nebivolol  Nilotinib   Pyrimethamine  Oxprenolol   Niraparib   Quinine  Pindolol   Nivolumab   r personal use only. Not for distribution. For p for distribution. Not only. use r personal Sodium stibogluconate   Propranolol  Obinutuzumab   Sulfadoxine   Sotalol   Ofatumumab   Antipsychotics/Neuroleptics Timolol  Olaratumab   Amisulpride   Bisphosphonates Oxaliplatin   Aripiprazole   Alendronic acid   Paclitaxel  Panitumumab   Asenapine  Clodronate   Pembrolizumab   Chlorpromazine   Ibandronic acid   Rituximab   Chlorprothixene  Pamidronate   Clozapine   Sorafenib   Risedronate   Flupentixol  Sunitinib Fluphenazine  Bronchodilators Tamoxifen   Haloperidol  Formoterol   Temsirolimus   Iloperidone Indacaterol   Vinblastine   Levomepromazine   Ipratropium bromide   Vincristine   Olanzapine   Montelukast   Vinorelbine   Paliperidone  Omalizumab   Contraceptives and Hormone Replacements Perazine   Salbutamol   Conjugated estrogens (HRT)   Periciazine   Salmeterol   Desogestrel (POP)   Perphenazine   Theophylline   Not only. use For personal for distribution. Not only. use personal Desogestrel/ethinylestradiol Pimozide    Tiotropium   (COC) For personal use only. Not for distribution. Fo for distribution. Not only. use For personal Pipotiazine   For Calcium Channel Blockers Dienogest   Prochlorperazine   Amlodipine  Drospirenone (POP)   Quetiapine   Diltiazem  Risperidone  Drospirenone/estradiol Felodipine   Sulpiride   (HRT) Nicardipine  Drospirenone/estradiol Thioridazine    Tiapride   Nifedipine (HRT) Nisoldipine Dydrogesterone/estradiol Trifluoperazine     Ziprasidone   Nitrendipine  (HRT) Zuclopentixol  Verapamil  Estradiol   Ethinylestradiol   Etonogestrel (implant)   Etonogestrel (vaginal ring)   Gestodene/ethinylestradiol   (COC)

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with PBC Agents

Charts created March 2020. Full information available at www.hep-druginteractions.org Page 3 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycho Acid Acid Acid Acid Acid lic Acid Contraceptives and Hormone Replacements (cont) Gastrointestinal Agents Herbals/Supplements/Vitamins Levonorgestrel (COC)   Aluminium hydroxide   Aloe vera   Levonorgestrel Alverine citrate   Ascorbic acid (Vitamin C)     (Emergency Contraception) Antacids   Black cohosh (A. racemosa)   Levonorgestrel (HRT)   Aprepitant   Cat’s claw (U. tomentosa)   Levonorgestrel (implant)   Bisacodyl   Colecalciferol (Vitamin D3)   Cimetidine   Cyanocobalamin (B12)   Levonorgestrel (POP)   Cisapride Diosmin  

Medroxyprogesterone (depot)   Cyclizine   Echinacea   Medroxyprogesterone (oral)   Dantron   Eucalyptus globulus   Medroxyprogesterone/   Domperidone   Folic acid   conjugated estrogens (HRT) Droperidol   Garlic   Medroxyprogesterone/   Esomeprazole   Ginger (Z. officinale)   estradiol (HRT) Famotidine   distribution. Ginkgo biloba   Norelgestromin/ethinylestradiol   Granisetron   Ginseng   (patch) Hyoscine   Goldenseal (H. canadensis)   Norethisterone Ispaghula husk   Grape seed extract   (Norethindrone) (depot  Lactulose   Grapefruit juice   injection) Lansoprazole   Green tea (C. sinensis)   only. Not for distribution. for only. Not Norethisterone Linaclotide   Homeopathic remedies    (Norethindrone) (POP) Loperamide   Inula racemosa   Norethisterone Lubiprostone   Iodine   (Norethindrone)/estradiol  Macrogol   Iron supplements   (HRT) Mebeverine   Kava kava (P. methysticum)  

Norethisterone use ersonal Mesalazine   Milk thistle   (Norethindrone)   Methylcellulose   Retinol (Vitamin A)   ethinylestradiol (COC) Metoclopramide   Riboflavin (Vitamin B2)   Norethisterone Naloxegol   Serenoa repens   (Norethindrone)/mestranol   Omeprazole   St John’s wort   (COC) Ondansetron   Thiamine (Vitamin B1)   Norgestimate/ethinylestradiol Pantoprazole   Turmeric (curcumin)     (COC) Prucalopride   Valerian   Norgestrel/conjugated Rabeprazole  Vitamin E     estrogens (HRT) Ranitidine   HIV Drugs

Norgestrel/ethinylestradiol Senna   for Not only. use For personal for distribution. Entry/Integrase Inhibitors   (COC) Simeticone   Bictegravir/FTC/TAF   Sulfasalazine   Erectile Dysfunction Agents Dolutegravir   Trimebutine   Sildenafil   Dolutegravir/rilpivirine   Tadalafil   HCC Therapies Elvitegravir/cobi /FTC/TAF   Vardenafil   Pembrolizumab   Elvitegravir/cobi/FTC/TDF   Regorafenib   Ibalizumab-uiyk   Hepatitis Drugs Maraviroc   Adefovir  Raltegravir   Daclatasvir   NNRTIs Elbasvir/Grazoprevir   Doravirine   r personal use only. Not for distribution. For p for distribution. Not only. use r personal Glecaprevir/Pibrentasvir   Doravirine/3TC/TDF   Entecavir   Efavirenz  Lamivudine   Etravirine   Ledipasvir/Sofosbuvir   Nevirapine  OBV/PTV/r   Rilpivirine   OBV/PTV/r + Dasabuvir   Rilpivirine/dolutegravir   Peginterferon alfa-2a   Rilpivirine/FTC/TAF   Peginterferon alfa-2b   NRTIs Ribavirin   Abacavir   Simeprevir   Didanosine   Sofosbuvir (SOF)   Emtricitabine (FTC)   SOF/Velpatasvir   Emtricitabine + TAF   SOF/Velpatasvir/Voxilaprevir   Emtricitabine + TDF   Telbivudine   Lamivudine   Tenofovir alafenamide (TAF)   Stavudine   Tenofovir-DF   Tenofovir-DF   Zidovudine   Protease Inhibitors Atazanavir alone   personal use only. Not for distribution. For personal use only. Not Not only. use For personal for distribution. Not only. use personal Atazanavir/cobicistat  

For personal use only. Not for distribution. Fo for distribution. Not only. use For personal  For Atazanavir + ritonavir  Darunavir/cobicistat   Darunavir/cobi/FTC/TAF   Darunavir + ritonavir   Fosamprenavir   Indinavir  Lopinavir  Ritonavir   Saquinavir  Tipranavir 

charts reflect the more cautious option.

www.hep-druginteractions.org

Interactions with PBC Agents

Charts created March 2020. Full information available at www.hep-druginteractions.org Page 4 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Hypertension/Heart Failure Agents Immunosuppressants Other Drugs Acebutolol   Adalimumab   Acamprosate   Aliskiren   Alemtuzumab   Acetazolamide   Ambrisentan   Azathioprine   Acitretin  Amiloride   Basiliximab   Activated charcoal   Azilsartan   Brodalumab   Allopurinol     Benazepril   Ciclosporin   Atomoxetine Eculizumab   Atropine  

Bendroflumethiazide   Baclofen   Bosentan  Etanercept   Benralizumab   Bumetanide   Fingolimod   Lenalidomide   Betahistine   Candesartan   Mycophenolate  Bimatoprost   Captopril   Pirfenidone   Biperiden 

Chlorothiazide   distribution. Sirolimus  Brinzolamide   Chlortalidone     Tacrolimus  Bromocriptine Cilazapril   Calcitonin   Lipid Lowering Agents Clevidipine   Calcium carbimide   Atorvastatin   Clonidine   Calcium resonium   Bezafibrate   Doxazosin  Cannabidiol (CBD)   only. Not for distribution. for only. Not

Ezetimibe  Enalapril   Carbimazole   Fenofibrate   Carisoprodol  Eplerenone   Fish oils   Epoprostenol   Cilostazol   Fluvastatin  Clomifene   Eprosartan   Gemfibrozil   Colchicine   Fosinopril   ersonal use ersonal Lovastatin   Colestyramine  Furosemide   Pitavastatin   Conivaptan   Hydralazine   Pravastatin   Cyclobenzaprine  Hydrochlorothiazide   Rosuvastatin   Cytisine   Iloprost   Simvastatin   Darbepoetin   Indapamide   Oxytocics Deferiprone   Irbesartan   Ergometrine (ergonovine)   Denosumab   Isradipine Mifepristone   Dexamfetamine  Ivabradine   Misoprostol  Dextromethorphan   Lacidipine  Parkinsonism Agents Disulfiram 

Lercanidipine  Benztropine   for Not only. use For personal for distribution. Donepezil  Lisinopril   Carbidopa   Dorzolamide   Losartan   Orphenadrine  Dupilumab   Macitentan   Pramipexole  Eliglustat   Epoetin alfa   Methyldopa   Procyclidine   Etelcalcetide   Metolazone   Rasagiline  Febuxostat  Moxonidine   Ropinirole  Filgrastim   Olmesartan   PBC Agents Flibanserin  Perindopril   Obeticholic acid  Gadopentetate (gadolinium)   Prazosin   Ursodeoxycholic acid  Glycerol phenylbutyrate   Quinapril  For p for distribution. Not only. use r personal Steroids Goserelin   Ramipril   Beclometasone   Influenza vaccine   Ranolazine Betamethasone   Isosorbide mononitrate   Rilmenidine   Budesonide  Isotretinoin Riociguat   Ciclesonide   Lanreotide   Selexipag  Clobetasol (topical)   Levothyroxine   Sildenafil   Clobetasone (topical)   Lofexidine   Spironolactone   Dexamethasone   Lumacaftor/Ivacaftor   Tadalafil   Fludrocortisone   Magnesium   Flunisolide   Melatonin   Telmisartan   Fluticasone   Memantine  Torasemide   Hydrocortisone (topical)   Methylphenidate   Trandolapril   Methylprednisolone   Minoxidil   Treprostinil  Mometasone   Modafinil   Valsartan   Prednicarbate   Naftidrofuryl   Xipamide   Prednisone   Nalmefene   Zofenopril   Triamcinolone   Naloxone   Illicit/Recreational Urological Agents Naltrexone   Alcohol   Alfuzosin   Neostigmine   personal use only. Not for distribution. For personal use only. Not Not only. use For personal for distribution. Not only. use personal Nicorandil   Amphetamine  Desmopressin   Cannabis   Nusinersan   For personal use only. Not for distribution. Fo for distribution. Not only. use For personal Dutasteride  For Ocrelizumab   Carfentanil   Finasteride  Orlistat Cocaine   Mirabegron   Penicillamine   Ecstasy (MDMA)  Silodosin   Pentoxifylline   GHB (Gamma-hydroxybutyrate)   Solifenacin   Phenylephrine   Heroin   Tamsulosin   LSD (Lysergic acid Pilocarpine    Tolterodine   diethylamide) Piracetam   Mephedrone  Potassium   Methamphetamine  Protamine sulphate   Phencyclidine (PCP)  Pseudoephedrine   Pyridostigmine  

Raloxifene   Sevelamer   Strontium ranelate   Thalidomide   Tranexamic acid   Varenicline  

charts reflect the more cautious option.