www.hep-druginteractions.org Interactions with PBC Agents Charts created March 2020. Full information available at www.hep-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Anaesthetics & Muscle Relaxants Antibacterials (continued) Antidepressants Bupivacaine Cloxacillin Agomelatine Cisatracurium Dapsone Amitriptyline Isoflurane Delamanid Bupropion Ketamine Ertapenem Citalopram Nitrous oxide Erythromycin Clomipramine Propofol Ethambutol Desipramine Thiopental Flucloxacillin Desvenlafaxine Tizanidine Gentamicin Dosulepin Analgesics Imipenem Doxepin Aceclofenac Isoniazid Duloxetine Alfentanil Escitalopram Aspirin Levofloxacin Linezolid Fluoxetine Buprenorphine Fluvoxamine Lymecycline distribution. Celecoxib Imipramine Meropenem Codeine Lithium Methenamine Dexketoprofen Maprotiline Metronidazole Dextropropoxyphene Mianserin Moxifloxacin Diamorphine Milnacipran Diclofenac Nitrofurantoin only. Not for distribution. for only. Not Mirtazapine Diflunisal Norfloxacin Moclobemide Dihydrocodeine Ofloxacin Nefazodone Etoricoxib Penicillin V Nortriptyline Fentanyl Piperacillin Paroxetine Flurbiprofen Pivmecillinam Sertraline Hydrocodone use ersonal Pyrazinamide Tianeptine Hydromorphone Rifabutin Trazodone Ibuprofen Rifampicin Indometacin Trimipramine Rifapentine Ketoprofen Venlafaxine Rifaximin Mefenamic acid Vortioxetine Meloxicam Spectinomycin Antidiabetics Metamizole (Dipyrone) Streptomycin Acarbose Methadone Sulfadiazine Albiglutide Morphine Tazobactam Alogliptin Naproxen Telithromycin Canagliflozin Oxycodone Temocillin for Not only. use For personal for distribution. Dapagliflozin Paracetamol Tetracyclines Dulaglutide Pethidine (Meperidine) Ticarcillin Empagliflozin Piroxicam Trimethoprim/Sulfamethoxazole Exenatide Tapentadol Troleandomycin Glibenclamide (Glyburide) Tramadol Vancomycin Gliclazide Anthelmintics Anticoagulant, Antiplatelet & Fibrinolytic Glimepiride Albendazole Acenocoumarol Glipizide Ivermectin Anagrelide Insulin Oxamniquine Apixaban Linagliptin Praziquantel Clopidogrel Liraglutide Pyrantel For p for distribution. Not only. use r personal Dabigatran Lixisenatide Antiarrhythmics Dalteparin Metformin Amiodarone Danaparoid Nateglinide Bepridil Dipyridamole Pioglitazone Digoxin Edoxaban Repaglinide Disopyramide Eltrombopag Dofetilide Enoxaparin Rosiglitazone Dronedarone Fluindione Saxagliptin Flecainide Fondaparinux Sitagliptin Lidocaine (Lignocaine) Heparin Tolbutamide Mexiletine Phenprocoumon Vildagliptin Propafenone Prasugrel Antifungals Quinidine Rivaroxaban Amphotericin B Vernakalant Streptokinase Anidulafungin Antibacterials Ticagrelor Caspofungin Amikacin Ticlopidine Fluconazole Amoxicillin Tinzaparin Flucytosine Ampicillin Warfarin Griseofulvin Azithromycin Anticonvulsants Isavuconazole Aztreonam Carbamazepine Itraconazole Bedaquiline Not only. use For personal for distribution. Not only. use personal Clonazepam Ketoconazole Benzylpenicillin Eslicarbazepine For personal use only. Not for distribution. Fo for distribution. Not only. use For personal For Miconazole Capreomycin Ethosuximide Nystatin Cefaclor Gabapentin Posaconazole Cefadroxil Lacosamide Terbinafine Cefalexin Lamotrigine Cefazolin Levetiracetam Voriconazole Cefixime Oxcarbazepine Cefotaxime Perampanel Cefradine Phenobarbital Ceftaroline Phenytoin Ceftazidime Pregabalin Ceftriaxone Primidone Cefuroxime Retigabine Chloramphenicol Rufinamide Ciprofloxacin Sultiame Clarithromycin Tiagabine Clavulanic acid Topiramate Clindamycin Valproate (Divalproex) Clofazimine Vigabatrin Zonisamide Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude No clinically significant interaction expected Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law. charts reflect the more cautious option. www.hep-druginteractions.org Interactions with PBC Agents Charts created March 2020. Full information available at www.hep-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Antihistamines Antivirals Cancer Therapies Astemizole Aciclovir Abiraterone Bilastine Amantadine Acalabrutinib Cetirizine Brivudine Anastrozole Chlorphenamine Cidofovir Avelumab Desloratadine Foscarnet Axitinib Diphenhydramine Oseltamivir Bevacizumab Doxylamine Blinatumomab Rimantadine Ebastine Valaciclovir Bortezomib Fexofenadine Zanamivir Bosutinib Hydroxyzine Brentuximab vedotin Anxiolytics/Hypnotics/Sedatives Levocetirizine Capecitabine Loratadine Alprazolam Carboplatin Amobarbital distribution. Promethazine Cetuximab Bromazepam Terfenadine Chlorambucil Antimigraine Agents Bromperidol Cisplatin Almotriptan Buspirone Cyclophosphamide Dihydroergotamine Clobazam Daratumumab Eletriptan Clorazepate only. Not for distribution. for only. Not Dasatinib Ergotamine Clotiapine Doxorubicin Frovatriptan Diazepam Erlotinib Methylergonovine Estazolam Estramustine Naratriptan Flurazepam Etoposide Pizotifen ersonal use ersonal Lorazepam Everolimus Rizatriptan Lormetazepam Exemestane Sumatriptan Midazolam (oral) Fludarabine Zolmitriptan Midazolam (parenteral) Gefitinib Antiprotozoals Oxazepam Gemcitabine Amodiaquine Idarubicin Artemether Quazepam Imatinib Artemisinin Temazepam Ipilimumab Artesunate Triazolam Irinotecan Atovaquone Zaleplon Ixazomib Chloroquine Zolpidem Dihydroartemisinin Zopiclone for Not only. use For personal for distribution. Lapatinib Letrozole Doxycycline Beta Blockers Medroxyprogesterone Halofantrine Atenolol (oncology) Hydroxychloroquine Bisoprolol Mercaptopurine Lumefantrine Carvedilol Mesna Mefloquine Celiprolol Pentamidine Labetalol Methotrexate Primaquine Metoprolol Mitoxantrone Proguanil Nebivolol Nilotinib Pyrimethamine Oxprenolol Niraparib Quinine Pindolol Nivolumab r personal use only. Not for distribution. For p for distribution. Not only. use r personal Sodium stibogluconate Propranolol Obinutuzumab Sulfadoxine Sotalol Ofatumumab Antipsychotics/Neuroleptics Timolol Olaratumab Amisulpride Bisphosphonates Oxaliplatin Aripiprazole Alendronic acid Paclitaxel Panitumumab Asenapine Clodronate Pembrolizumab Chlorpromazine Ibandronic acid Rituximab Chlorprothixene Pamidronate Clozapine Sorafenib Risedronate Flupentixol Sunitinib Fluphenazine Bronchodilators Tamoxifen Haloperidol Formoterol Temsirolimus Iloperidone Indacaterol Vinblastine Levomepromazine Ipratropium bromide Vincristine Olanzapine Montelukast Vinorelbine Paliperidone Omalizumab Contraceptives and Hormone Replacements Perazine Salbutamol Conjugated estrogens (HRT) Periciazine Salmeterol Desogestrel (POP) Perphenazine Theophylline Not only. use For personal for distribution. Not only. use personal Desogestrel/ethinylestradiol Pimozide Tiotropium (COC) For personal use only. Not for distribution. Fo for distribution. Not only. use For personal Pipotiazine For Calcium Channel Blockers Dienogest Prochlorperazine Amlodipine Drospirenone (POP) Quetiapine Diltiazem Risperidone Drospirenone/estradiol Felodipine Sulpiride (HRT) Nicardipine Drospirenone/estradiol Thioridazine Tiapride Nifedipine (HRT) Nisoldipine Dydrogesterone/estradiol Trifluoperazine Ziprasidone Nitrendipine (HRT) Zuclopentixol Verapamil Estradiol Ethinylestradiol Etonogestrel (implant) Etonogestrel (vaginal ring) Gestodene/ethinylestradiol (COC) Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should