Authors: J. Michael Cherry Eurie Hong Benjamin Vincent Cynthia Krieger An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Rama Balakrishnan Ron Caspi Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. YeastCyc: Saccharomyces cerevisiae S288c Cellular Overview Connections between pathways are omitted for legibility. Julie Park Hartmut Foerster

taurine isethionate urea spermidine a phosphatidylserine spermidine spermidine SAM sn-glycero-3-phospho-1-inositol arsenate phosphate a tripeptide myo-inositol L-cysteate sulfate sulfate nicotinate spermine spermine spermidine spermidine putrescine D-mannose phosphate phosphate phosphate phosphate phosphate glutathione glutathione [+ 4 more] spermine putrescine putrescine putrescine putrescine sn-glycero-3-phosphocholine arsenous acid phosphate a dipeptide Ups2-Mdm35 Ups1-Mdm35 YNL294C fimbrin YGR068C YBL075C YMR177W YDR497C YOL103W YLR121C YNL093W YOL020W YGR122W YDR153C YAL014C YML072C YCR028C phosphatidylserine YDR524C-B YLR120C YHR161C YGL160W YOR071C YLR237W YOR192C YHR073W YLR422W YDR055W YIL166C YPR003C YLR092W YBR294W YNR056C YGL186C YOL084W YNL180C YGR260W YMR212C YGR125W YGR143W SUR7 YJL020C YGR138C YPR156C YLL028W YOR273C YPL274W YOR273C YHL016C YLL028W YPL274W YKL174C YER060W YNL283C YGL082W YCL048W-A YNR074C YJR001W YDR309C YMR031C YBR293W YDR420W YMR086W YOR008C YNL087W YGR197C YFR012W YMR215W YDR373W phosphatidate YCR098C YGR031C-A YAL030W YLL043W YHR094C YCR037C YER053C YCR098C YML123C YJR077C YBR296C YJL198W YNR013C YNL083W YPL244C YJR152W YKR106W YCL073C YML006C YFL055W YDL072C SKT5 YCR024C-A YCR007C YLR241W YLR194C YIL088C YDL229W YGR289C YFL047W YOR107W YNL145W YLL061W YAR066W YDR414C YPL176C YBL029C-A YNL033W YGR241C YLL053C YER103W YKR093W YLL007C BZZ1 YFL014W YBR069C YJR151C transporter transporter YDR046C spermidine (R)- sn-glycero-3-phospho-1-inositol antimonite UDP-α-D- a tripeptide myo-inositol myo-inositol thiamine thiamine sulfate sulfate pyridoxine spermine spermine spermine putrescine phosphate phosphate phosphate phosphate phosphate galactose N-carbamoyl-L-aspartateglutathione glutathione pantothenate a phosphatidate sn-glycero-3-phosphocholine acetic acid allantoate a dipeptide arsenous acid ATP a peptide YLR188W a peptide

2+ YIL121W Cu 2+ Cu YFR020W Cofactor, Carrier, and Vitamin Biosynthesis Metabolic Regulator Biosynthesis Macromolecule Modification tRNA splicing 7 tRNA-uridine 2-thiolation (cytoplasmic) 10-cis-heptadecenoyl- 10-trans-heptadecenoyl- Fatty Acid and Lipid Degradation a [histone H3] N a 5'-(N -methyl 5'- 6 a mitochondrial YDR270W sphingolipid recycling and degradation (yeast) 9-cis, 11-trans-octadecadienoyl-CoA CDP-choline a 1-arachidonoyl- 2-oxoglutarate 6 6 a [histone]-N - hydrogen a reduced a [DNA]-3'- a nucleoside a siderophore- phosphoenola mRNA with an L-asparaginyl- fumarate iron-sulfur cluster biosynthesis γ Amine and Polyamine Biosynthesis CoA degradation CoA degradation ,N -dimethyl- triphosphoguanosine)- preprotein Asn glu superpathway of ubiquinol-6 biosynthesis (eukaryotic) 4-amino-2-methyl-5- flavin biosynthesis III (fungi) NAD de novo biosynthesis superpathway of tetrahydrofolate biosynthesis and salvage -glutamyl cycle thiamin formation from pyrithiamine and oxythiamine thiamin salvage IV superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) thiamine diphosphate pyridoxal 5'-phosphate salvage I S-adenosyl-L-methionine salvage II Other Biosynthesis fructose 2,6- a polycistronic degradation (isomerase-dependent) Aldehyde Degradation 2-acyl-sn-glycerol acetyl-L-lysine peroxide thioredoxin hydroxyl triphosphate bound Fe(III) pyruvate poly(A) tail [tRNA ] YAL063C II (from tryptophan) bisphosphate biosynthesis (reductase-dependent) (4R)-4-hydroxy-N-[(2R)-2- L-lysine-36 (ribonucleotide)-[mRNA] including a medium- fumarate cupric phosphomethylpyrimidine biosynthesis biosynthesis tRNA precursor cys 10-cis-heptadecenoyl-CoA proteasome 2+ UDP-N-acetylglucosamine 10-trans-heptadecenoyl-CoA hydroxy-very-long-chain-acyl]-1- 9-cis, 11-trans- CTP HMP-PP mitochondrial phosphatidate chain reductase reductase: Fe all-trans-hexaprenyl + IV (eukaryotes) meso-butanediol spermidine biosynthesis I diacylglycerol (glutathion-S histone DNA endopeptidase putative YMR319C + GTP pyrithiamine thiamine aldehyde:NAD+ NAD 4-methyl-5-(2- pyridoxine biosynthesis II (R,R)-butanediol biosynthesis choline biosynthesis III (4R)-4-hydroxy-N-[(2R)-2-hydroxy- O-[hydroxy(6-O-{6-O-[(1D-myo- octadecadienoyl-CoA fatty acid oxidation (non-cyclic) methylglyoxal methylglyoxal [histone-H3]- ribonuclease 5'-(N(7)-methyl 5'- peptide:N- Peptidyl- putative targeting sequence DNA- poly(A)- phosphatidate phosphatase: Peptidyl- fatty acid glutamate- (NADH) FRE2 Cu diphosphate SAH biosynthesis tRNA-splicing L-cysteine methylglyoxal cholinephosphotransferase: dimethyl-L- -yl)-bimane deacetylase: Ligase: complex: SEM1 ferric-chelate pyruvate specific ethyl ester : FRD1 YBL060W L-cysteine tryptophan 2,3- oxidoreductase: phosphooxyethyl) desulfurase: (4R)-4-hydroxy-N-[(2R)-2- very-long-chain-acyl]-1-O-{[6-O-(α- inositol-1-O-yl)phosphoryl]-α-D- degradation V degradation VII EPT1 P: RPM1 RPM2 triphosphoguanosine)- carboxypeptidase: glycanase: phosphatidate Trna thioredoxin DNL4 LIF1 directed RNA RPN12 RPN11 reductase: phosphatase: PAH1 Trna -cysteine cupric thiaminase ALD2 NAD(+) putative pyridoxamine S-adenosyl-L-homocysteine endonuclease: 6-cis-tridecenoyl-CoA mannosyl}-1D-myo-inositol-1-O-yl) a 2,3,4-saturated catabolism lysine-36 PNG1 DEP1 RXT3 peroxidase: kinase: ribonuclease: PAH1 phosphatidate synthase: ligase: fumarate reductase: desulfurase: 4-aminobenzoate:hexaprenyl- phosphoribosylpyrophosphate GTP dioxygenase: GTP- II: THI20 thiaminase II: THI20 kinase: POS5 thiazole pyridoxal hydrolase: SAH1 phosphocholine NFS1 ISD11 6-trans-tridecenoyl-CoA hydroxy-very-long-chain-acyl]- D-mannosyl)-1D-myo-inositol-1-O- 5-cis, 7-trans- fatty acid diacylglycerol ribonuclease (mRNA) diphosphatase: ATG42 cytidylyltransferase: bifunctional Hydrolase: RPD3 SDS3 Cell mitochondrial- polymerase: RPN9 RPN8 RPN7 FRE8 CAF130 Hydrolase: NFS1 ISD11 amidotransferase: ADE4 cyclohydrolase gamma- aldehyde:NAD+ (R,S)-2,3- putative SEN54 SEN34 an [L-cysteine 1-O-[(1D-myo-inositol-1-O-yl) yl]hydroxyphosphoryl}sphinganine hydroxyphosphoryl]sphinganine tetradecadienoyl-CoA methylglyoxal demethylase: P: RPR2 POP8 DCS2 DCS1 CDS1 hydroxyethylthiazole PTH1 SCO2 processing RPB10 PYK2 phosphatidate phosphatase: PTH1 EEB1 GSH1 reductase FRE1 YLR411W Cu + diphosphate BNA2 cyclohydrolase glutathione NAD(+) kinase: putative (R,R)-butanediol choline-phosphate bifunctional fatty-acyl methylglyoxal methylglyoxal cholinephosphotransferase: GIS1 (glutathion-S RXT2 UME1 Division RPN6 RPN5 RPN3 [+ 5 isozymes] CCR4 MOT2 + glutamyltransferase: TMP SEN15 SEN2 aldehyde 7 thioredoxin peptidase: pyruvate (NADH) Cu an S-sulfanyl-[L- hexaprenyltransferase: COQ2 5-phospho-β- ubiquinol-6 biosynthesis from II: RIB1 I: FOL2 synthetase: 4-amino-2-methyl-5- oxidoreductase: kinase: YEF1 BUD17 pyridoxal butanediol dehydrogenase: glutamine-- cytidylyltransferase: PCT1 S-adenosylmethionine fructose-2,6- desulfurase]-S- coenzyme A fatty acyl-CoA hydroxyphosphoryl]sphinganine fatty acyl-CoA reductase: GRE3 glyoxalase CPT1 POP7 POP6 5'-(N -methyl 5'- putative kinase/thiamine- aminoacyl- SIN3 CTI6 RPA43 RPN10 RPT1 RPT2 NOT5 POP2 phosphatase: LPP1 aminoacyl- medium- 2,5-diamino-6- GSH2 ECM38 5-(2-hydroxyethyl)-4-methylthiazole ALD3 diphosphorylase: dehydrogenase: fructose-6- bisphosphate 2-YLR345W: sulfanyl-L-cysteine oxidase: POX1 mannosyl-inositol- mannosyl- 2,3,4- dehydrogenase: [histone H3]- POP1 POP5 POP4 -yl)-bimane phosphate peroxidase: Cycle: MAS2 MAS1 RPA12 kinase: LPP1 chain γ : OSM1 YMR034C cysteine desulfurase] D-ribosylamine 4-hydroxybenzoate (eukaryotic) (5-phospho-D- arylformamidase: pyrimidinemethanol NAD(+) pyridoxine kinase: 5-methyltetrahydropteroyltriglutamate--homocysteine BDH1 decarboxylase: SPE2 YLR345W oxidase: POX1 α α oxidase: POX1 saturated NADPH- I: GLO1 triphosphoguanosine) carboxypeptidase: phosphatidate tRNA PHO23 SAP30 CDC9 RPT3 RPT4 RPT5 CAF40 CDC39 bifunctional tRNA -L-glutamyl- hydroxymethylpyrimidine aldehyde THI6 BDH1 phosphate phosphatase/6- cysteine inositol-phospho- phospho- diphosphoinositol- (R)-S- ALD4 lysine-36 RPP1 POP3 RPR1 -[mRNA] cytidylyltransferase: diphosphorylase: THI6 hydrolase: DOT5 RPA49 RPT6 RPN13 RPN2 2+ CDC19 diacylglycerol hydrolase: fatty acid succinate + ISU1 scaffold 3-all trans-hexaprenyl- ribosylamino) hydroxymethylpyrimidine hydroxyethylthiazole kinase: UTR1 kinase: BUD17 pyridoxal fructose-2,6- 2-trans-6-trans- fatty PRC1 [+ 5 isozymes] Fe a siderophore NOT3 CDC36 bifunctional D-alanine YPR124W Cu 4-hydroxybenzoateall-trans-hexaprenyl BNA3 (HMP) kinase: THI21 dehydrogenase S-methyltransferase: MET6 transaminase: diacylglycerol putrescine phosphofructo- desulfurase:TUM1 hydroxyphytoceramide hydroxyphytoceramide ceramide dependent lactoylglutathione aldehyde demethylase: diphosphatase: DCS1 TAM41 PTH2 RPO26 RPN1 PRE5 PRE8 diacylglycerol diphosphate PTH2 ethyl ester protein: ISU1 diphosphate 4-aminobenzoate pyrimidin- Arylformamidase: (HMP) kinase: THI21 kinase: THI6 thiamine BUD16 pyridoxamine bisphosphatase: tridecadienoyl-CoA phospholipase: ISC1 phospholipase: ISC1 phospholipase: ISC1 acyl-CoA methylglyoxal JHD1 RPB5 RPB8 Poly(A)- synthase: HMP kinase: HMP kinase: THI20 (NAD+): ALD5 YMR084W cholinephosphotransferase: 2-kinase: tRNA sulfurtransferase: trans--2-enoyl- trans--2-enoyl- an acyl-CoA glyoxylase- dehydrogenase an oxidized H O [DNA] a peptide PRE2 PRE6 PRE1 diphosphate phosphatase/ ISU2 scaffold 3-hexaprenyl-4- 4(3H)-one BNA7 THI20 phosphate pyridoxine kinase: BUD16 putative met glucoseamine- CPT1 YLR345W FBP26 tRNA ligase: TUM1 trans--2-enoyl- ligase: reductase: GRE2 (NAD+): ALD5 a tRNA precursor with (γ-glutamylcysteine- thiamine 2 RPA135 PRE3 PRE7 PRE4 pyruvate binding protein- phosphatidate EHT1 2,5-diamino-6- aldehyde II: GLO4 a tRNA fragment a CDP-1-acyl- acetate a [histone]-L-lysinethioredoxin phosphatase/ + YDR349C para- aminobenzoate 2'-hydroxypyridoxol spermidine synthase: SPE3 a ubiquitin- a [3-mercaptopyruvate CoA hydratase CoA hydratase a very-long-chain (2'R)- CoA hydratase FAA2 (S)-lactaldehyde a short 3' extension a diphospho-5'- phosphate Asn protein: ISU2 para- (ribosylamino) 7,8- dehydrogenase: Digs Into 5'-phosphate pyridoxamine pyridoxal 6-phosphate diacylglycerol [+ 2 isozymes] ligase: TRL1 glyoxalase II aldehyde:NAD+ formaldehyde a [histone H3]- S-yl)-bimane 2-arachidonoyl- an N-modified RPA14 PUP2 PRE9 PUP3 dependent phosphatidate phosphatase: tRNA YNL321W Na an S-sulfanyl-[cysteine hydroxybenzoate:hexaprenyl- monooxygenase: aldehyde 5'-phosphate kinase: methionine TRL1 a 3' half-tRNA related modifier 1 sulfurtransferase]-S 2: FOX2 2: FOX2 2'-hydroxy-phytoceramide 2: FOX2 [+ 3 isozymes] putative L-lysine-36 succinate purine-3'-[mRNA] amino acid RPC10 poly(A) COQ6 hydroxybenzoate:hexaprenyl- -4(3H)- dihydroneopterin oxythiamine TMP NADHALD4 glucose-6- NADP-dependent Agar: DIA3 adenosyltransferase: SAM1 D-glucosaminesynthase: GFA1 cholinephosphotransferase: -sulfanyl-L-cysteine aldehyde (cytoplasmic) oxidoreductase: glycerol PUP1 SCL1 PRE10 phosphatase: DPP1 desulfurase]-[disordered- diphosphate diphosphate pyrimidinone putative putative diphosphorylase: dehydrogenase phosphate isocitrate acetaldehyde:NADP+ pyridoxine 5'- BUD17 EPT1 a 5' half-tRNA molecule with URM1 fatty acid beta-oxidation dihydroceramidase: (3R)-hydroxy- 5-cis, 7- dodecenoyl- ALD3 RPC19 riboNuclease: DPP1 form scaffold hexaprenyltransferase: COQ2 kynurenine 3- 3'-phosphate γ phosphomethylpyrimidine [+ 3 isozymes] methionine 6-phosphate spermidine molecule with TUM1:MOCS3 V (unsaturated, dehydrogenase: : GLO2 a peptide PAN2 PAN3 phosphatidate hexaprenyltransferase: COQ2 5'-phosphate -L-glutamyl- cys gly thiaminase phosphomethylpyrimidine THI6 (NADP+): ALD5 dehydrogenase: dehydrogenase: oxidoreductase: ALD6 phosphate pyridoxiamine pyridoxal a phosphate adenylyltransferase: YDC1 trans-tetradecadienoyl-CoA CoA ALD4 aldehyde:NAD+ RPA190 + + protein] complex monooxygenase: kinase: THI22 thiamine adenosyltransferase: SAM2 glucosamine-6- a 2' phosphate UBA4 sulfurtransferase: 3-hydroxyacyl-CoA 3-hydroxyacyl-CoA odd number, di- phytoceramidase: YPC1 3-hydroxyacyl-CoA isomerase: RPA34 RPC40 phosphatidate phosphatase: Na YLR138W Na YOR188W [cysteine desulfurase]-S- pyridoxine reductase: RIB7 L-cysteine II: THI20 kinase: THI22 NADH aldehyde ZWF1 IDP2 oxidase: 5'- phosphate kinase: on its 5' end aldehyde oxidoreductase: 1-[18-phosphatase:1-stearoyl-APP1 YOL154W 3-hexaprenyl-4- 2,5-diamino-6- BNA4 hydroxymethylpyrimidinethiamine phosphate kinase: UTR1 dehydrogenase: PDX3 oxidase: PDX3 BUD16 phosphate N- spermine and on its 3' end a carboxy- UBA4 dehydrogenase: dehydrogenase: isomerase-dependent) dehydrogenase: DCI1 sulfanylcysteine:[acceptor (5-phospho- 5-(2-hydroxyethyl) hydroxymethylpyrimidine thiamine acetyltransferase: methylthioadenosine biosynthesis a [MOCS3]-S- FOX2 FOX2 a (5Z)-alkan- a phytosphingosine dehydrogenase D-lactate ALD2 [+ 3 isozymes] hydroxyoeoyl]-APP1 2-palmitoyl- protein]-cysteine hydroxybenzoate 3-all trans- 3-hydroxy- D-erythro-7,8- Cys-Gly phosphate (HMP- phosphate (HMP- NADH ALD4 phospholipase D: SPO14 a carboxymethyluridine 34 adenylated-[ubiquitin- 5-enoyl-CoA FOX2 fatty-acyl d3,d2- pyruvate 2-[18-hydroxy- sn-glycerol hexaprenyl- pyridoxine 4- D-ribitylamino) L-kynurenine -4-methylthiazole pyrophosphokinase: GNA1 tRNA related modifier 1] sulfanylcysteine 6-trans-3-oxo- fatty-acyl (NAD+): ALD5 dehydrogenase + + sulfurtransferase: NFS1 putative 3-hexaprenyl-4- dihydroneopterin metallodipeptidase: P) kinase: THI21 P) kinase: THI21 Digs Into Agar: DIA3 kinase: YEF1 aldehyde:NADP+ THI80 in tRNA 6-cis, 3-oxo-tridecenoyl-CoA 5-cis, 7-trans-3-oxo- coenzyme Enoyl-CoA linoleoyl]- Na YDR038C Na 3-hexaprenyl-4- 4-amino-5- pyridoxal dehydrogenase/ pyrimidin- chorismate DUG1 hydroxyethylthiazole HMP-P kinase: THI20 [+ 3 isozymes] NAD/NADP-NADH/NADPH SAM ligase: tridecenoyl-CoA coenzyme tetradecadienoyl-CoA A oxidase: Isomerase: aldehyde:NAD+ (cytochrome) YDR090C pyridoxal hydroxybenzoate 4(3H)-one kynureninase: dihydroneopterin HMP-P NADH oxidoreductase: putrescine TRL1 tRNA URM1 wybutosine biosynthesis A oxidase: oxidoreductase: : DLD3 RNA sn-glycerol hydroxybenzoate hydroxybenzoate kinase: gamma- kinase: THI6 kinase: POS5 ALD6 mitochondrial interconversion biosynthesis III 34 3-ketoacyl-CoA 3-ketoacyl-CoA POX1 ECI1 YIL123W monooxygenase: deaminase/ BUD17 reductase: monooxygenase: 2,5-diamino- BNA5 aldolase: FOL1 aminodeoxychorismate folate interconversions 4-methyl-5-(2- kinase: THI20 HMP-PP pyridoxal 5'-phosphate biosynthesis II (carboxymethyluridine - sulfurtransferase: POX1 dihydroceramidase: 3-ketoacyl-CoA ALD3 D-lactate COQ6 glutamylcysteine S-adenosylmethionine 37 Phe thiolase: POT1 thiolase: POT1 phytosphingosine + COQ6 hydroxylase: COQ6 YPR127W 6-ribitylamino- 6-(hydroxymethyl) synthase: ABZ1 phosphooxyethyl) N-acetylglucosamine- a 2'-phospho- 5-O)-methyltransferase: UBA4 guanine in tRNA YDC1 thiolase: POT1 aldehyde:NAD+ ferricytochrome c YDR039C Na pyridoxine 3-hydroxyanthranilate synthetase: GSH1 thiamine superpathway of glutathione phosphate decarboxylase: SPE2 Phe 37 1 a (2E)-2- a 2,3,4-saturated a tRNA a 2'- (12Z,15Z)-9,10- a 1-arachidonoyl- a 1-acyl-2- L-cysteine kinase: 3-all trans-hexaprenyl- 4(3H)- -7,8-dihydropterin a 5-methyltetrahydrofolate thiazole NADPH metabolism (truncated γ-glutamyl cycle) arg [ligated tRNA] TRM9 TRM112 tRNA (guanine -N )- oxidoreductase: oxidoreductase: CDP-choline tributyrin S-methyl-L- ADP a ribonucleoside a uridine in tRNA O-phospho- an L-cysteinyl- ATP biotin desulfurase: pyrimidinone pyrophosphokinase: D-glyceraldehyde mutase: PCM1 a thiocarboxylated- 4-trans-undecenoyl-CoA putative phytosphingosine enoyl-CoA 1,2-diacyl-sn- precursor with deoxyribonucleoside[DNA] epoxyoctadeca- diphosphate cys 2-acyl-sn-glycerol arachidonoyl- [tRNA Cys ] cys dGMP YBR054W 3-all trans-hexaprenyl- BUD16 4,5-dihydroxybenzoate 3-hydroxyanthranilate 2-amino-4-hydroxy-6- dAdoMet spermidine arginase: tRNA 2'- methyltransferase: TRM5 phytosphingoid kinase: LCB5 ALD2 DLD1 glycerol 3-phosphate a 5' extension 5'-triphosphate methionine tRNA L-homoserine 3-phosphate cyanamide NFS1 4,5-dihydroxybenzoate S-adenosyl-L- 5'-phosphate hydroxymethyldihydropteridine TMP THI80 3-phosphate [ubiquitin-related dodecenoyl- trans-2- histone 12,15-dienoatebifunctional ribonucleoside- phosphatidatesn-glycerol L-cysteine YLR042C an S-sulfanyl-[cysteine 3,4-dioxygenase: BNA1 aminodeoxychorismate NADH:ubiquinone glutathione CAR1 phosphotransferase: fatty acyl-CoA fatty acyl-CoA CoA 1-phosphate phytosphingosine sphinganine putative acetyltransferase: diphosphate dihydrouridine 3-phosphatephosphatidate hydratase: dGMPa sterol YOR011W a sterol thioredoxin methionine:3- deaminase: pyrophosphokinase: FOL1 diphosphorylase: gamma- modifier 1] oxidase: POX1 oxidase: POX1 dodecenoyl-CoA enoyl-CoA pyruvate diacylglycerol 8-OxoGuanine TGL1: TGL1 glutathione aminopeptidase/ ATP synthase: DUS1 phosphatase: biotin-- desulfidase: desulfurase]-S- S-adenosyl-L- 3,4- RIB2 2-amino-3- (7,8-dihydropterin- lyase: ABZ2 thiamine diphosphate oxidoreductase 2 biotin biosynthesis from pyridoxal 5'- TPT1 isomerase: phsophatase: LCB3kinase: LCB4 sphinganine kinase: LCB5 hydratase phosphatidate decapping ribonuclease DNA- AdoMet- TRA1 SPT7 TAF5 epoxide reductase: cystathionine arginine/alanine PAH1 phosphatase: palmitoyl- aminoacyl- IRC7 DDI2 kinase: sulfanyl-[disordered- system methionine:3- putative hexaprenyl-4,5- dihydroxy-2- carboxymuconate- methylenetetrahydrofolate THI6 folate transformations I (external): NDE2 aldehyde NAD(+) 8-amino-7-oxononanoate I glutamyltransferase: spermine synthase: SPE4 tRNA-4-demethylwyosine isomerase: DCI1 L-lactate cholinephosphotransferase: Glycosylase/ phospholipase A2: TGL4 S-conjugate adenylyltransferase: tRNA [acetyl-CoA- dihydroxybenzoate 6-yl)methyl reductase: MET13 dehydrogenase kinase: POS5 phosphate ECM38 UDP-N- tRNA-5-(2-methoxy- (2E, 4E)-undeca- DCI1 phytosphingosine sphinganine 1-phosphate sphinganine 2: FOX2 EPT1 lyase: OGG1 cytidylyltransferase: enzyme P: RPR2 directed DNA homocysteine intermediate NGG1 GCN5 hydrolase: LAP2 RNR1 RNR3 gamma- aminopeptidase: phosphatidate PAH1 (protein) tRNA carboxylase] cystathionine cyanamide GUK1 form scaffold hexaprenyl-4,5- pyridoxal butanone-4- 6-semialdehyde 4-aminobenzoate glu NADH:ubiquinone synthase: acetylglucosamine ornithine Appr>p 2-oxoethyl)uridine synthase: TYW1 2,4-dienoyl-CoA 1-phosphate phosphatase: YSR3kinase: LCB4 ∆3-∆2-enoyl-CoA a 2,3,4- dehydrogenase: TriacylGlycerol CDS1 carboxypeptidase: polymerase SPT3 TAF6 HFI1 APA1 RNR2 RNR4 dihydrouridine synthase: STR2 hydrolase: hydrolase: hydratase: an oxidized kinase: O-methyltransferase: diphosphate methylenetetrahydrofolate nicotinamide (NAD+): ALD5 decarboxylase: d3,d2- kinase: LCB3 diacylglycerol Lipase: TGL5 complex POP8 ATG42 methyltransferase: cleaving epoxide AAP1 phosphatase: phosphatidate ligase: BPL1 gamma- YIL013C YBR162C protein] complex[cysteine desulfurase]-S- dihydroxybenzoate phosphate thiamine phosphate riboside salvage oxidoreductase 1 SNZ3 SNO3 an α-(γ-L- pyrophosphorylase: spermine 2-sulfurtransferase: 37 Phe Enoyl-CoA phosphatase: YSR3sphinganine sphinganine sphinganine isomerase: ECI1 saturated (3R)-3- CYB2 APurinic/ putative catalytic POP7 POP6 alpha: SAM4 peptidase TAF12 SPT20 5',5'''-P-1,P-4- synthase: DUS4 phosphatase: TML25 PTH2 DDI3 dGDP thioredoxin O-methyltransferase: pyridoxine 5'- BUD17 COQ3 reductase: MET12 aldehyde 7,8-diamino- SPE1 ADP ribose 1'',2''- 4-demethylwyosine in tRNA 2,4-dienoyl-CoA 2,4-dienoyl-CoA cholinephosphotransferase: apyrimidinic bifunctional triglyceride lipase/ glutathione hydrolase: ribonucleotide- vacuolar LPP1 lyase: CYS3 sulfanylcysteine:[acceptor synthase: dihydro-6- methylenetetrahydrofolate pathway II (external): NDE1 pyridoxal 5'- glutamyl)-L- L-cysteinylglycine QRI1 cyclic phosphate 2''- NCS6 Isomerase: kinase: YSR3 1-phosphate kinase: LCB3 (2E,5E)-dodeca- hydroxyacyl-CoA pyruvate phosphatidate subunit: POP1 POP5 POL12 POL1 S-Methylmethionine 55: ICP55 ADA2 CHD1 YNR064C tetraphosphate tRNA aminopeptidase LPP1 COQ3 phosphate pyridoxal 3-all trans-hexaprenyl-4- RIB3 dehydrogenase: pelargonic acid amino acid tRNA 4-demethylwyosine reductase: SPS19 reductase: SPS19 3-hydroxyacyl-CoA CPT1 eNdonuclease: lysophosphatidylethanolamine S-conjugate SGF73 TAF10 phosphorylase diphosphate dihydrouridine bifunctional pyruvate protein]-cysteine NAD salvage hydroxymethylpterin reductase: MET13 NADH:ubiquinoneALD4 phosphate Cys-Gly putrescine phosphodiesterase ECI1 phosphatase: LCB3sphinganine 2,5-dienoyl-CoA cytidylyltransferase: DCP1 DCP2 POP4 RPP1 [+ 8 isozymes] Homocysteine reductase: L-cystathionine ysc1: APE1 bifunctional choline YGL077C choline sulfurtransferase: NFS1 thioredoxin- 3-all trans-hexaprenyl-4- oxidase: kinase: hydroxy-5-methoxybenzoate quinolinate pyrophosphokinase: a 5,10- oxidoreductase aminotransferase: synthase: a 5-(2-methoxy- α-amino-α- (3E)-undec-3-enoyl-CoA kinase: YSR3 trans--2-enoyl- dehydrogenase: APN1 acyltransferase: TGL3 TAM41 POP3 RPR1 carboxypeptidase: TAF9 RTG2 UBP8 II: APA2 synthase: DUS3 diacylglycerol a tRNA Cys pathway IV (from PDX3 BUD16 methylenetetrahydrofolate BIO3 metallodipeptidase: cyclic 2-oxoethyl)2- a (3E,5Z)-alka- a 1-acyl-2-oleoyl- [+ 3 isozymes] PRC1 methylTransferase: a fully-processed RNR2 a 5,6- diphosphate diacylglycerol cys YLR037C disulfide hydroxy-5-methoxybenzoate FOL1 methylenetetrahydrofolate methylenetetrahydrofolate nicotinamide (internal): NDI1 SNZ2 SNO2 phosphodiesterase: 34 carboxypropyltransferase: CoA hydratase FOX2 a 5'- [+ 9 isozymes] nicotinamide riboside) quinolinate reductase: MET12 methylenetetrahydrofolate lipoate biosynthesis and incorporation IV (yeast) (7R,8S)-diaminononanoate DUG1 thiouridine in tRNA protein ubiquitination putative putative 3,5-dienoyl-CoA phytosphingosine sn-glycero-3- a [DNA]-3'-α,β- [+ 2 isozymes] MHT1 mitochondrial a [histone]-N 6 - a 2'-RNR4 RNR1 dihydrouridine diphosphate reductase: 1-(β-D dehydrogenase dehydrogenase ribose pyridoxal 5'- CPD1 TRM12 ∆ ∆ sphinganine 1-phosphate 2: FOX2 phosphopurine- protein in tRNA phosphatase/ phosphatase/ phosphoribosyl thymidylate + aldehyde γ dodecenoyl-CoA dodecenoyl-CoA 3,5- 2,4- 1-phosphate phosphocholine unsaturated acetyl-L-lysine Ap4A deoxyribonucleoside phosphatidate TRR2 ribofuranosyl) 2-all trans-hexaprenyl- 7,8- a 5,10- (NADP ): ADE3 a 5-methyltetrahydrofolateserine (NADP + ): ADE3 nucleosidase: -L-glutamyl- glutathione [mRNA] γ-L-glutamyl-[(S phosphatidate YGL167C 6,7-dimethyl-8- transferase methenyltetrahydrofolate 5-oxoprolinase synthase: glycine URH1 dehydrogenase dethiobiotin phosphate L-cysteine isomerase: DCI1 isomerase: DCI1 dienoyl-CoA aldolase: DPL1 Cofactor, Prosthetic Group, Electron Carrier Degradation aldehyde 1,2-dibutyrin 5'-diphosphate phosphatase: thioredoxin- nicotinamidenicotinamide 6-methoxyphenol ribityllumazine (decarboxylating) dihydropteroate methylenetetrahydrofolate hydroxymethyltransferase: methylenetetrahydrofolate NADH synthetase: BIO4 synthase: synthetase: a [ubiquitin] C-terminal glycine isomerase: dihydrosphingosine 3-oxoacyl )-allyl]-L-cysteine phosphatase: disulfide riboside trifunctional formate- (ATP- CDC21 cleavage nicotinamide (NADP+): ALD5 Phe ∆3-∆2-enoyl-CoA ∆3-∆2-enoyl-CoA phosphate lyase: DPL1 DPP1 synthase: RIB4 : BNA6 dihydrofolate glycine dehydrogenase SHM2 system: dehydrogenase SNO1 SNZ1 GSH2 protein tRNA [7-[(3S)-(3-amino- DCI1 (R)-2-hydroxyhexadecanal 3-hydroxyacyl-CoA CoA glutathione degradation DPP1 frataxin: YFH1 reductase: kinase: NRK1 tetrahydrofolate ligase/ hydrolysing) NAD-dependent 5,10- + + aldehyde E1 ubiquitin- isomerase: ECI1 isomerase: ECI1 thiolase: periplasmic phosphatidate synthase: FOL3 cleavage (NADP ): MIS1 glycine GCV3 (NADP ): MIS1 NEDDylation 3-carboxypropyl)-4- a (2E,4E)-2,4- dehydrogenase: phosphatidate 2+ TRR1 NMN NaMN methenyltetrahydrofolate : OXP1 methylenetetrahydrafolate octanoyl NADH dehydrogenase: gamma- activating protein: demethyl]wyosine-N 4 ]- 2-hydroxyhexadecanal palmitaldehyde FOX2 POT1 (DUG pathway) NAD degradation phosphatase: YGR191W Mn 6,7-dimethyl-8-(1- 7,8-dihydrofolate system: hydroxymethyltransferase:GCV1 NAD-dependent 5,10- ALD4 putative ADP- UBA2 AOS1 (2E)-undec-2-enoyl-CoA dienoyl-CoA phosphatase: a [cysteine desulfurase]- D-ribityl)lumazine cyclohydrolase/ dehydrogenase: MTD1 SHM1 transferase: kinase: POS5 biotin glutamylcysteine methyltransferase: TYW3 dehydrogenase: HFD1 (5E)-3-oxo-dodec- a 2,3,4-saturated APP1 [scaffold protein- nicotinamide- nicotinate nucleotide monoglutamate methylenetetrahydrofolate GCV3 GCV2 methylenetetrahydrafolate LIP2 synthetase: GSH1 ribose 1''- E1 ubiquitin- 2,4-dienoyl- aldehyde a 1-arachidonoyl- APP1 riboflavine GCV1 LPD1 dehydrogenase: MTD1 synthase: BIO2 phosphate E1 NEDD8- 7-[(3S)-(3-amino-3-carboxypropyl) trans--2-enoyl- trans--2-enoyl- aldehyde dehydrogenase: ALD4 5-enoyl-CoA fatty acyl CoA glutathione γ-glutamate 2-acyl-sn-glycerol (2Fe-2S)] complex a reduced nucleotide adenylyltransferase: dehydrogenase: ADE3 octanoyl-CoA activating 37 Phe CoA NADH 2+ thioredoxin 2-hexaprenyl- synthetase: a 7,8-dihydrofolate serine NADPH phosphatase: activating ]-wyosine in tRNA CoA hydratase CoA hydratase dehydrogenase hydrolase: ECM38 Mn YOR079C JAC1 co- adenylyltransferase: NMA1 methenyltetrahydrofolate phosphopantothenate biosynthesis I GCV2 hydroxymethyltransferase: 5-formyltetrahydrofolate a [glycine- protein: UBA1 2: FOX2 2: FOX2 reductase: aldehyde 3-ketoacyl-CoA pyrophosphatase: chaperone: 2-hexaprenyl- POF1 6-methoxy-1,4- RIB5 LPD1 trifunctional formate- cyclo-ligase: FAU1 cleavage complex PDL32 enzyme: 7-(3-amino-3- SPS19 (NAD(+)): ALD2 dehydrogenase thiolase: POT1 glutathione hydrolase: benzoquinol nicotinate nucleotide cyclohydrolase: MIS1 SHM2 6 NPY1 JAC1 6-methoxy-1,4- tetrahydrofolate ligase/ a tetrahydrofolate octanoyl- octanoyl- H protein] N - an [E1 UBA3NEDD8- ULA1 carboxypropyl)-wyosine aldehyde (NAD+): ALD5 DUG3 DUG2 Man GlcNAc - (9Z,15Z)-12,13- 2819 4-hydroxy- a 1-palmitoyl-2- nicotinamide methyltransferase: riboflavin adenylyltransferase: 10 3-methyl-2- biotin ADP-ribose 9 2 2-(glutathion-S-yl) + a uridine a peptide with phosphoenol YDR461W benzoquinol an N - oxobutanoate glycine methenyltetrahydrofolate trifunctional formate- CoA-protein CoA-protein octanoyl-L-lysine synthase: BIO2 activating methyltransferase: PPM2 dehydrogenase (3E)-dec-3-enoyl-CoA 10-trans-heptadecenoyl- oleate β-oxidation CDP-choline a ferrocytochrome [protein] (isomer diphosphate NADPH H 5'-phospho- epoxy-octadeca- palmitoyl-CoAH O 4-methyl-2- an N-terminal acyl-sn-glycerol ser thr YHR132C methyltransferase: mononucleotide COQ5 NMA2 hydroxymethyltransferase: tetrahydrofolate ligase/ transferase: transferase: 1''-phosphate (NAD(+)): ALD3 aldehyde b -2-carboxypropane in 21S rRNA 2 dADP pyruvate dAMP YOL122C adenylyltransferase: riboflavin formyltetrahydrofolate 3-methyl-2-oxobutanoate cyclohydrolase/ lipoyl phosphatase: enzyme]-S- dehydrogenase CoA degradation (isomerase- IMP 5'- 5 8A B ) ribonucleotide- 9,15-dienoate 21S rRNA oxoglutarate L-aspartate 3-phosphate bifunctional pyruvate COQ5 2-all-trans-hexaprenyl- dihydrofolate SHM1 methylenetetrahydrofolate methenyltetrahydrofolate AIM22 AIM22 synthase: coenzyme A biosynthesis II (eukaryotic) folate polyglutamylation PEroXin: PEX4 putative putative Cys-Gly 1,2,3,4 1,4 His bifunctional 2819 bifunctional 4- phosphatidate L-threonine Multicopy lipoate NMA2 kinase: hydroxymethyltransferase: dihydrofolate POA1 [NEDD8 protein]- (MFE-dependent) dependent) nucleotidase: ISN1 [tRNA ] pseudouridine chorismate suppressor kinase: dAMP SSQ1 6-methoxy-3-methyl- reductase: phosphoribosylglycinamide reductase: dehydrogenase: ADE3 cyclohydrolase/ LIP5 yl-L-cysteine [+ 10 isozymes] dodecenoyl- (NAD(+)): ALD3 dodecenoyl-CoA metallodipeptidase: diacylglycerol bifunctional triglyceride lipase/ Neuropathy glutathione NADPH aminopeptidase/ synthase: PUS5 acyl-CoA hydroxy-4-methyl- phosphatase: deaminase: PYK2 salvage I 4-amino-2-methyl-5- FMN1 ECM31 formate--tetrahydrofolate a [2-oxoglutarate- 7-(3-amino-3- oleoyl-CoA ceramide very inorganic carboxypeptidase putative arginine/alanine aspartyl synthase/ serine--tRNA of Kex2 Cold kinase: 2+ YOR306C chaperone: nicotinamide 1,4-benzoquinol glutamine- DFR1 formyltransferase: ADE8 DFR1 methylenetetrahydrofolatethiazole biosynthesis III E2 NEDD8- an [E2 ubiquitin- (3R)-hydroxynonanoyl-CoA CoA aldehyde isomerase: DCI1 DUG1 cholinephosphotransferase: lysophosphatidylethanolamine initiation-specific α-1,6- Target S-conjugate dehydrogenase: His epoxide thioesterase: 2-oxoglutarate PAH1 CHA1 Mn YHR050W phosphomethylpyrimidine hydroxymethylpyrimidine methenyltetrahydrofolate ligase: MIS1 dehydrogenase NAD salvage pathway V (PNC V cycle) ADP-D-ribose conjugating methylcarboxypropyl) dehydrogenase trans--2-enoyl- long chain pyrophosphatase: C: ATG42 aminopeptidase: tRNA hydrolase: LAP2 aminopeptidase: rRNA aminopeptidase: pyruvate riboflavin ligase: DIA4 sensitivity: pyruvate ADK1 SSQ1 mononucleotide 5-demethoxyubiquinol dependent 2-dehydropantoate dehydrogenase: ADE3 6 conjugating enzyme]-S isomerase: ∆3-∆2-enoyl-CoA EPT1 acyltransferase: TGL3 mannosyltransferase: Esterase: carboxypeptidase: OYE3 ATF1 aldolase/ phosphatidate threonine (R)-lipoate adenylyltransferase: synthase: THI5 salvage cyclohydrolase: MIS1 formate--tetrahydrofolate E2 protein] N - phosphopantothenate- enzyme: -ubiquitinyl-L-cysteine -wyosine (NAD(+)): ALD2 CoA hydratase fatty acid PPA2 carboxypeptidase YDR415C guanylyltransferase: AAP1 pseudouridine oxaloacetate APE4 kinase: reductase serine--tRNA MKC7 kinase: 5-demethoxyubiquinol hydroxylase: COQ7 NAD 10 methenyltetrahydrofolate DCI1 isomerase: ECI1 diacylglycerol sterol esterase: YEH2 OCH1 NTE1 ATG42 NADPH epoxide acyl-CoA phosphatase: ammonia- biotin YGR065C biotin putative a tetrahydrofolate an N - ligase: ADE3 + octanoyl-L-lysine carboxycarbonylase: PPM2 2: FOX2 (5Z)- hydroxylase: inorganic THG1 synthase: PYK2 [NAD(P) CDC19 hydroxylase: COQ7 NMA1 HMP-P FAD synthase: 4-amino-2-methyl-5- 2-dehydropantoate a tetrahydrofolate dehydro-D-arabinono- cyclohydrolase: MIS1 NAD cysteine ligase: CAB2 formate--tetrahydrofolate folyl- serine an [E2 NEDD8-UBC12 (3R)-hydroxy, 4-trans cholinephosphotransferase: sterol esterase: YEH1 phospholipase Y (proteinase bifunctional dehydrogenase: hydrolase: vacuolar thioesterase: decarboxylase: vacuolar LPP1 ligase: SES1 lyase: ILV1 lipoate-- synthetase: formyltetrahydrofolate lipoyl lipoyl protein acetyllysine N- HECT-type d3,d2- pentadecanoate (2E)-dec-2-enoyl-CoA tetradecenoyl-CoA SCS7 diphosphatase: glutathione aminopeptidase NOP10 CBF5 YER010C aminopeptidase pyruvate H]: ARO2 pyruvate xylitol YLL043W xylitol protein QNS1 pyrimidinemethanol nicotinate riboside 2-reductase: PAN5 1,4-lactone biosynthesis synthase: synthase: ligase: MIS1 polyglutamate hydroxymethyltransferase: acetyltransferase: SIR2 conjugating Enoyl-CoA -undecenoyl-CoA CPT1 TriGlyceride Lipase: TGL1 GDP B: PLB2 S-conjugate C): PRC1 aminopeptidase/ OYE2 YNR064C GAR1 NHP2 TES1 bifunctional 2-oxobutanoate glycerol glycerol 3-demethylubiquinol-6 putative FAD1 hydroxymethylpyrimidine salvage pathway I synthase: RMA1 SHM2 enzyme]-S- E3 ubiquitin 3-hydroxy-heptanoyl-CoA 3-hydroxy-heptanoyl-CoA 2,3,4-saturated fatty 2,3,4-saturated fatty fatty IPP1 epoxide 5'-phospho- ysc1: APE1 ysc1: APE1 kinase: YDR534C ligase: S-adenosyl-L- (HMP) kinase: THI21 β-alanine adenylated thiazole LIP5 LIP5 formate--tetrahydrofolate glutamine-dependent [+ 5 isozymes] Isomerase: 3-hydroxyacyl-CoA acyl-CoA [+ 2 isozymes] phospholipase carboxypeptidase: guanosine- CDC19 diacylglycerol an L-seryl- YKL051W phosphomethylpyrimidine a [pyruvate a [2-oxoglutarate phosphopantothenoylcysteine ligase: ADE3 folylpolyglutamate glycine mRNA capping I [NEDD8-protein]- transferase: RING-type ECI1 acyl-CoA ligase: FAA2 acyl-CoA ligase: FAA2 dehydrogenase: hydrolase: LAP2 sec AIM22 methionine:2- HMP kinase: THI20 10 synthase: THI4 NAD synthase: QNS1 RSP5 BUL2 oxidase: Amine and Polyamine Degradation CMP B: PLB1 PRC1 a proteinogenic + ribonucleotide- diphosphate [tRNA ] SSQ1 S-adenosyl-L- glutathione- kinase: THI22 prenylated FMNH D-arabinose 1- an N - dehydrogenase dehydrogenase decarboxylase: CAB3 VHS3 SIS2 synthetase: MET7 hydroxymethyltransferase: yl-L-cysteine E3 ubiquitin [+ 3 isozymes] [+ 3 isozymes] FOX2 + a peptide NADP His palmitate hexaprenyl-3- HMP-P 2 6 6 10 POX1 [+ 2 isozymes] amino acid [tRNA ] phosphatase/ YFL054C chaperone methionine:2- glutaredoxin biosynthesis nicotinate glutathione redox reactions I dehydrogenase formyltetrahydrofolate E2 protein] N E2 protein] N an N - a 5'-triphospho- cullin-RING- [+ 3 isozymes] transferase: β phosphate H a peptide asp ATPase: redox reactions hydroxymethylpyrimidine methyl-5-hydroxy- pantoate formate--tetrahydrofolate D-arabinose ADP-5-ethyl-4- SHM1 nicotinate adenine dinucleotide HECT-type pentadecanoyl-CoA palmitoyl-CoA oleate -oxidation superpathway of allantoin a fatty acid lys a peptide phosphatidate putative hexaprenyl-3- phosphate (HMP- lipoate biosynthesis putative riboside β dehydrogenase:(NAD(P) -lipoyl-L-lysine -lipoyl-L-lysine 4'-phosphopantetheine formyltetrahydrofolate ribonucleotide-[mRNA] type E3 UBX2 SSM4 (reductase-dependent) (2E,5Z)- 4-aminobutyrate YGR037C FAD YAL053W FAD SSQ1 lipoate-- methyl-5-hydroxy- 6-methoxy-1,4- and incorporation I kinase: -alanine ligase: MIS1 (+)): ARA2 methylthiazole-2-carboxylate mRNA 5'- NEDD8 E3 ubiquitin [+ 27 isozymes] 3-hydroxypentanoyl-CoA tetradecenoyl-CoA degradation in yeast gly phosphatase: glutathione P) kinase: THI21 benzoquinol O- phosphomethylpyrimidineprenol DMAPP ligase: PAN6 formate--tetrahydrofolate ARA2 folyl- triphosphate 3-ketoacyl-CoA degradation DPP1 protein 6-methoxy-1,4- glutathione- kinase: THI22 NRK1 D-arabinose 4-methyl-5-(2- pantetheine- transferase: transferase: UFD4 glycerol YPL189W a [chaperone- HMP-P methyltransferase: base-degraded ligase: ADE3 phosphate polyglutamate nicotinate nucleotide nicotinamidase: PNC1 phosphatase: thiolase: POT1 (S)-(+)-allantoin phosphatidate FAD YPL221W FAD an [2Fe-2S] ligase: benzoquinol O- kinase: glutaredoxin an octanoyl-[acp] hydroxymethylpyrimidine NaMN 4-methyl-5(β- dehydrogenase: phosphonooxyethyl) synthase: RMA1 folyl- adenylyltransferase: NMA1 amidase: AMD2 RTT101 [+ 3 isozymes] 4-aminobutanoate ADP]-[disordered- AIM22 methyltransferase: COQ3 thiamin salvage (R)-pantothenate Glutathione thiazole adenylyltransferase: CET1 MMS1 triacylglycerol oleate β-oxidation ∆3,5-∆2,4- phosphatase: cluster protein form scaffold THI20 system LIPoyl phosphate (HMP- glutathione- hydroxyethyl) ARA1 folypolyglutamate polyglutamate nicotinate nucleotide a diphospho-5'- degradation (thioesterase- dienoyl-CoA (3Z)-dodec- allantoinase: gamma- APP1 COQ3 ligase formylaminopyrimidine peroxidase: glutathione synthase: THI4 CAB4 ribonucleotide-[mRNA] HRT1 ESC2 a [protein]-N 6 - protein S-nitrosylation and denitrosylation aminobutyrate YNL190W protein] complex S-adenosyl- ubiquinol-6 GSSG P) kinase: THI21 disulfide thiazole salvage D-arabinono-1,4-lactone synthetase: MET7 synthase: RMA1 adenylyltransferase: NaMNNMA2 nicotinate 6 phosphatidylcholine resynthesis dependent) isomerase: 3-enoyl-CoA DAL1 glycerol YDR536W glycerol HMP-PP L-methionine a [lipoyl-carrier2: LIP2 pantothenate GPX1 peroxidase: mRNA a [cullin]-N - monoubiquitinyl-L-lysine via glycerophosphocholine a triacyl-sn trans--2-enoyl- transaminase: SSQ1 ubiquinol-6 monothiol protein] N 6 - HMP-P kinase: THI20 prenyl phosphate kinase: CAB1 reductase: acyl carrier protein activation folypolyglutamate [NEDD8-protein]- -glycerol (2E,4E)-DCI1 ∆3,∆2- chaperone glutaredoxin: biosynthesis glutathione GTT1 D-arabinono- synthetase: MET7 guanylyltransferase: tetradeca-2,4- CoA hydratase UGA1 octanoyl-L-lysine aminomethylpyrimidine (R)-4'- peroxidase: [+ 3 isozymes]GRX6 hydroxyethylthiazole 1,4-lactone dephospho- CEG1 yl-L-lysine CDP-choline triacylglycerol putative 2: FOX2 enoyl-CoA succinate ATPase: GRX3 glutathione- dienoyl-CoA 55 lipoyl flavin [+ 3 isozymes] kinase: THI6 oxidase: ALO1 an apo acyl- CoA kinase: a 5,10- lipase: TGL3 dodecenoyl- isomerase: semialdehyde 1D-myoinositol 2-(2-carboxy-4- a 1-acyl-2- 1-chloro-2,4- (9Z,12Z)-15,16- 37 a uridine type-1 uridine glycerol YGL084C glycerol SSQ1 thiamin salvage III disulfide thiaminase phosphopantothenate GPX2 4-methyl-5-(2- methylenetetrahydrofolate nicotinate phosphoribosyl 5-oxo-L-proline metabolism diacylglycerol 2,4-dienoyl- a ferrocytochrome a (6S)-5- methylthiazol-5- glutathione epoxyoctadeca- DMAPP an adenosine detyrosinated tyr transmembrane YBR067C [+ 2 isozymes] methionine synthase: II: THI20 prenyltransferase: phosphooxyethyl) dehydro-D- carrier protein CAB5 transferase: NPT1 cholinephosphotransferase: triacylglycerol CoA ECI1 allantoicase: succinate b 5-diphosphate arachidonoyl- dinitrobenzene in tRNA α-tubulin ala GTP a protein uridine an [Fe-S cluster reductase: PAD1 Phosphopantetheine:Protein CoA DAL2 5 formyltetrahydrofolate 1,2,3,4,6- yl)ethyl phosphate sn-glycero-3- 9,12-dienoate in tRNA bifunctional bifunctional YJL219W adenosyltransferase: LIP5 thiazole arabinono-1,4-lactone a [protein] with a [protein] with a [protein] 3- CPT1 lipase: TGL5 isomerase: putative semialdehyde bifunctional bifunctional proteinsputative endopeptidase alanine Ca2+- kinase: biosynthesis GRX6 a [lipoyl-carrier 4-amino-2-methyl-5- glutathione Transferase: PPT2 coenzyme A mRNA (guanine-N 7 ) reductase: dehydrogenase: pentakisphosphate phospho-D- DRAP rhomboid chorismate catalytic GTP SAM1 6 TMP a holo acyl- an N-terminal an N-terminal nitrosothio- DCI1 dodecenoyl- glutathione 1D-myoinositol 5- glutathione aminopeptidase/ ferric transaminase: diphosphatase: dependent URK1 chaperone]-ATP thiamine [+ 3 isozymes] protein]-N -[(R) pyrimidinemethanol -methyltransferase: diacylglycerol triacylglycerol SPS19 CoA diacylglycerol C-4 methyl bifunctional cysteine ubiquitin- tetrahydrofolate diphosphate 1,2,3,4,6- bifunctional myo-inositol 4,5- RNase H: RNH70 transfer RNA putative deaminase/ putative diacylglycerol protease: synthase/ subunit: IMP1 serine methionine diphosphorylase: carrier protein L-glutamine L-glutamate L-alanine cholinephosphotransferase: lipase: TGL4 ∆3,∆2- urea UGA2 cholinephosphotransferase: specific S-conjugate transferase: RNase H: epoxide Xaa-Pro reductase: diphosphate ALT1 NPP1 uridine YCR004C YIL169C pyrophosphokinase: -dihydrolipoyl]- THI6 ABD1 isomerase: sterol synthase/O-acetylhomoserine synthase: MET7 pentakisphosphate hydroxyethylthiazole bisphosphate hydrolase: LAP2 isopentenyl tRNA tubulin RBD2 riboflavin IMP2' SOM1 protease: THI80 adenosyltransferase: L-lysine 7 EPT1 TGL1: enoyl-CoA succinate EPT1 protease: carboxypeptidase: GTT2 RNH203 transferase: dipeptidase: FRE1 phosphatase/ alanine [+ 2 isozymes] kinase: SAM2 thiamine a 5'-(N -methyl 5'- a phosphatidylcholine isomerase: DCI1 oxidase: aminocarboxypropyltransferase: putative ATG42 phosphatase: SIW14 kinase/thiamine- RNH202 RNH201 epoxide pseudouridine tyrosine Processing of reductase endopeptidase KEX2 DAS2 glutathione triphosphoguanosine)- TGL1 ureidoglycolate diacylglycerol ERG25 MET17 UBP14 phosphate glutathione MOD5 YFR006W synthase: RIB2 [+ 6 isozymes] ligase: phosphatidate [NAD(P) transaminase:GMP SAM phosphate [+ 3 isozymes] ECI1 putative (2E)-dodec- urea-lyase: DAL3 cholinephosphotransferase: [+ 14 isozymes] tetrahydrofolate diadenosine and phosphoinositide- transferase: hydrolase: phosphatase: Cytochrome catalytic ALT2 UMP (ribonucleotide)-[mRNA] glutathione a [protein] with phosphatidyl dodecenoyl- cysteine synthase: MCY1 synthase: RMA1 glutathione diphosphorylase: THI6 specific tRNA PBY1 c Peroxidase: H]: ARO2 subunit: IMP2 γ 2-enoyl-CoA diphosphoinositol (9Z,12Z)-15,16-YNR064C 6 55 DPP1 -L-glutamyl S-nitrosoglutathione a 1,2-diacyl- CPT1 S-conjugate GTT1 2+ YBR008C Amino Acid Biosynthesis an N-terminal 5- phospholipase CoA 4α-carboxy- polyphosphate phospholipase DNA a nucleoside 5'-dihydroxyoctadeca- N -(3-methylbut- a proteinogenic pro pseudouridine Fe a siderophore PCP1 reduced riboflavin EGT2 L-histidine biosynthesis superpathway of branched chain amino acid biosynthesis superpathway of sulfur amino acid glycine oxo-L-proline 5-phosphate B: NTE1 sn-glycerol acyl-CoA isomerase: glyoxylate urea 4β-methyl-5α- a [ubiquitin] C- carboxypeptidase: C: PLC1 monophosphate 2-en-1-yl)- amino acid synthase: PUS4 phosphatidate superpathway of L-serine L-homoserine L-phenylalanine aspartate biosynthesis L-threonine glutathione-specific gamma- 3-hydroxypentanoyl-CoA a (6S)-5- phosphohydrolase: 9,12-dienoate 37 phosphatase: STErile L-lysine biosynthesis IV biosynthesis (Saccharomyces cerevisiae) and glycine biosynthesis I biosynthesis glutamylcyclotransferase: S-nitrosoglutathione diacylglycerol thioesterase: DCI1 cholesta-8,24- acetate terminal glycine PRC1 thiamine 2,4-dinitrophenyl- adenosine tyrosinated biosynthesis biosynthesis I biosynthesis dehydrogenase: urea cys formyltetrahydrofolate DDP1 phosphate α-tubulin APP1 Secondary Metabolite Biosynthesis PRPP pyruvate from threonine GCG1 lipase: TGL3 TES1 ∆3-∆2- dien-3β-ol an 1-acyl-2- S-glutathione in tRNA YOR153W a drug 2-oxoglutarate pyruvate SFA1 carboxylase: γ-L-glutamyl-(S)- ATP pyruvate thr glycerophosphocholine (3E,5Z)- enoyl-CoA DUR1,2 arachidonoyl- YJL174W inositol phosphate biosynthesis homocitrate acetolactate 3-phosphoglycerate aspartate a 2-acylglycerol tetradecadienoate isomerase: methyl-L-cysteine gly sn-glycerol phosphatidylinositol phosphate biosynthesis homofuraneol myo-inositol D-myo-inositol (1,3,4)- phosphoribosyltransferase: L-threonine sulfate chorismate carboxylase: PYC1 homoserine L-threonine 5-oxo-L-proline phosphodiesterase: GDE1 fatty acid β-oxidation (peroxisome) YDR164C indole-3-acetate 1D-myo-inositol hexakisphosphate D-myo-inositol (1,4,5)-trisphosphate biosynthesis HIS1 synthase: synthase: dehydrogenase: SER33 kinase: mutase: ARO7 ECI1 fatty acid β-oxidation urea-1-carboxylate a 1-phosphatidyl- biosynthesis biosynthesis biosynthesis V biosynthesis I (from Ins(1,4,5)P3) trisphosphate biosynthesis LYS21 deaminase: adenylyltransferase: pyruvate kinase: THR1 aldolase: a drug YDR011W a drug ILV2 ILV6 CHA1 MET3 3-phosphoglycerate HOM3 prephenate carboxylase: PYC2O-phospho- GLY1 5-oxoprolinase acylglycerol 2,3,4-saturated III (unsaturated, 1D-myo-inositol myo-inositol D-glucopyranose (bacteria and fungi) 1-(5-phospho- homocitrate dehydrogenase: SER3 L-aspartyl- (ATP- lipase: YJU3 fatty acyl-CoA bifunctional a DNA containing 2-hydroxy-4-oxobutane- a uridine 65 a [protein]-L- D-myo-inositol (1,3,4,5) β-D-ribosyl)-ATP threonine oxaloacetate L-homoserine a (2E)-2-enoyl-CoAtrans-2-enoyl- odd number) coenzyme A CDP-choline glutathione a phytochelatin glutathione oxaloacetate a myo-inositol RNA 5 an acyl-CoA acetyl-CoA H O an L-glutamyl- 4,5-bisphosphate 6-phosphate (indol-3-yl)acetonitrile synthase: APS 3-phosphooxypyruvate 4-phosphate prephenate hydrolysing) ligase: FAA2 a (3Z)-alk-3- urea an apurinic/ 1,2,4-tricarboxylate in tRNA glutamate-O 2 Gln ITP phosphoinositide- L-myo-inositol- -tetrakisphosphate phosphoribosyl-ATP ammonia- dehydratase: threonine hydroxylamine CoA hydratase carboxylase/ apyrimidinic site ITP monophosphate bifunctional D-arabinose bifunctional -methyl-ester [tRNA ] 1,4-alpha- putative YOR030W phosphatidylinositol 1-phosphate nitrilase: NIT2 phosphatidylinositol LYS20 acetohydroxyacid superpathway of phenylalanine, tyrosine and tryptophan biosynthesis aspartic beta aspartate : OXP1 a fatty acid [+ 3 isozymes] fatty-acyl enoyl-CoA inositol- glycerol-3- (3R)-3- glutaminyl- very-long- YDR406W a drug specific inositol 1,4,5- pyrophosphatase: reductoisomerase: lyase: ILV1 adenylylsulfate phosphoserine PHA2 aminotransferase: synthase: 2: FOX2 putative allophanate phosphate aminopeptidase/ dehydrogenase: DRAP ITP glucan amidase: synthase: PIS1 synthase: [+ 2 isozymes] inositol 1,4,5- ARGRIII inositol synthase: PIS1 trisphosphate 3- inositol HIS4 transaminase: SER1 semi-aldehyde THR4 coenzyme A dodecenoyl- diacylglycerol phytochelatin bifunctional 4- epoxide polynucleotide acyl-CoA phosphate 1-O- hydroxyacyl- acetyl-CoA tRNA chain 3- diphosphatase: branching AMD2 phospholipase INO1 ILV5 (2Z)-2-aminobut- kinase: MET14 5-enolpyruvoyl- 3-deoxy-D-arabino- 3-dehydroshikimate dehydrogenase: 3-phenyl-2- AAT2 glu hydrolase: holo-[LYS2 peptidyl- Rab bifunctional N- protein- L-cysteine phosphoinositide- phosphatase: ARA1 deaminase/ protein-glutamate acyltransferase: [acyl-carrier- synthase C: PLC1 trisphosphate 3- polyphosphate a 1-phosphatidyl- kinase: ARG82 polyphosphate 1-(5-phospho-β- (2R)-2,3- 2-enoate shikimate 3-phosphate shikimate oxidase: POX1 CoA DUR1,2 carrier-protein] cholinephosphotransferase: synthase: PRC1 hydroxy-4-methyl- hydrolase: LAP2 adenylyltransferase: D-arabinose 1- tRNA thioesterase: hydrolase: oxoacyl- NPP1 enzyme: amidase: 1D-myo-inositol 5-phosphatase: shikimate 3-phosphate heptulosonate 7-phosphate HOM2 oxopropanoate aspartate thr phospholipids degradation a 2,3,4-saturated (3R geranylgeranyltransferase: glycosylase/ disulfide phosphoenolpyruvate desulfurase: 2-oxoglutarate specific INM1 AIR2 MTR4 methylesterase: SCT1 protein] ACH1 (glutamine- CoA arsenate YML123C kinase: ARG82 multikinase: D-ribosyl)-AMP dihydroxy-3- PAPS L-tyrosine:2- prephenate shikimate O-phospho-L-serine L-phenylalanine:2- aminotransferase: tRNA-uridine 2-thiolation (yeast mitochondria) )-3-hydroxyacyl-CoA isomerase: synthase: LYS5 EPT1 BET2 BET4 MRS6 phytochelatin reductase NFS1 ISD11 epoxide dehydrogenase pseudouridine PPE1 TES1 hydrolysing) [+ 2 isozymes] GLC3α NTA1 arsenate YBR129C norfuraneol ARG82 phosphatidylinositolIns(1,4,5)P INP53 chorismate 3-deoxy-D-arabine- 3-phosphoshikimate 1- 3-dehydroquinate 3-dehydroquinate shikimate 3-hydroxyacyl-CoA DCI1 carbamate diacylglycerol synthase: ATG42 AP lyase carboxykinase: PCK1 aldolase/ phospholipase INositol PAP2 HUL4 acyl-CoA glycerol-3- dehydratase: reductase: a (1,6)- -D- 3 phosphoribosyl- methylbutanoate oxoglutarate dehydrogenase: heptulosonate- carboxyvinyltransferase: dehydratase: ARO1 dehydrogenase: oxoglutarate AAT1 phosphatidylglycerol Phosphopantetheine:Protein ogg2: NTG1 (glutathione) C: PLC1 Monophosphatase: hydrolase: (NAD(P) synthase: RIB2 HTD2 : PET112 IMP glucosyl-(1,4) inositol 4-kinase: STT4 [+ 2 isozymes] cis-homoaconitate synthase: ARO2 synthase: ARO1 kinase: ARO1 phosphoserine a phosphatidylcholine dehydrogenase: d3,d2- cholinephosphotransferase: oxaloacetate YNR064C [+ 3 isozymes] (+)): ARA2 thioesterase: phosphate-O- a very-long-chainIFA38 phosphatidylinositol phosphatidylinositol monophosphate: AMP dihydroxy-acid phosphoadenosine aminotransferase: TYR1 7-phosphate ARO1 ARO1 aminotransferase: β degradation Transferase: PPT2 a geranylgeranylated [+ 4 isozymes] : GRX1 decarboxylase: INM2 (9Z)-12,13- tRNA a [protein]-α- acyltransferase: acetate HER2 GTF1 -α-glucan [+ 2 isozymes] cyclohydrolase: dehydratase: phosphosulfate ARO8 synthase: ARO3 3-dehydroshikimate phosphatase: SER2 homoserine ARO8 asp -alanine biosynthesis FOX2 Enoyl-CoA CPT1 D-arabinono- pseudouridineMeOH65 ATF1 an L-glutaminyl- oxoacyl-CoA arsenite YPR201W arsenite YOR009W inositol 1,4,5- 3-kinase: VPS30 4-kinase: STT4 INM2 homoaconitate 3-dehydroquinate shikimate 3-phosphate protein that [+ 2 isozymes] phosphoenolpyruvate ala YER010C dihydroxyoctadeca- L-glutamate 1-palmitoyl-GPT2 Gln trisphosphate 3- a 1-phosphatidyl- HIS4 ILV3 reductase: MET16 shikimate dehydrogenase: phospholipase a phosphatidylglycerol a 2,3,4-saturated Isomerase: IDP Ins(1,4)P 1,4-lactone synthase: PUS1 [tRNA ] VPS34 ATG14 [+ 2 isozymes] 1D-myo-inositol 3- hydratase: LYS4 3-deoxy-7- ends with a 2 9-enoate RNA 65 sn-glycerol YFL040W kinase: ARG82 D-myo-inositol inositol-1,3,4,5- 1D-myo-inositol 1-(5-phospho-β-D-ribosyl)- L-homoserine tyr phosphoheptulonate ser HOM6 spermine L-cysteine desulfurase: D: SPO14 phosphoinositide- phosphatidylglycerol fatty acyl CoA ECI1 a 1-palmitoyl-2-acyl-sn- a 3'-terminal a pseudouridine VPS15 ATG38 monophosphate 5-phosphate (1R,2S)- NFS1 ISD11 specific CCXX sequence unsaturated sugar in tRNA 3-phosphate (1,4,5,6)- a 1-phosphatidyl- tetrakisphosphate inositol-1,4,5,6- 5-[(5-phosphoribosylamino) chorismate anthranilate synthase: ARO4 spermine phospholipase C: PGC1 glycero-3-phosphocholine 2+ 2+ D-myo-inositol phosphatidylinositol phosphatase: INM1 methylideneamino]imidazole- homoisocitrate sulfite serine L-homoserine phospholipase a 1,2-diacyl- oxaloacetate Cd YOR291W Cd tetrakisphosphate 3-kinase: VPS34 1D-myo-inositol 6-kinase: ARG82 tetrakisphosphate phosphatidylinositol- phosphatidylinositol homoserine O- mutase: ARO7 synthase: oxidase: FMS1 an [L-cysteine desulfurase]- a phosphatidate YOL155C (1,3,4,5)- 4-phosphate myo-inositol 4-carboxamide homo-isocitrate L-valine:2- acetyltransferase: TRP2 TRP3 3-deoxy-D-arabino- hydroxymethyltransferase: L-alanine a uridine 34 in tRNA S-sulfanyl-L-cysteine C: PLC1 sn-glycerol 3-oxoacyl CoA YPL092W sulfite VPS15 VPS30 VPS38 (2E)-2- 3-kinase: ARG82 5-phosphate 4- 4-phosphate alpha- sulfite reductase: heptulosonate 7-phosphate SHM2 thiolase: POT1 tetrakisphosphate inositol-1,4,5,6- phosphatidylinositol kinase: MSS4 kinase: MSS4 phosphoribosyl-5-amino- dehydrogenase: isopropylmalate oxoglutarate acetolactate MET2 MET10 MET5 prephenate arginine biosynthesis superpathway of L-cysteine biosynthesis (fungi) methionine biosynthesis II cysteine 4-phosphate ethylidene- 1-phosphoribosyl-4- LYS12 salvage pathway glycine 3-aminopropanal:NAD(P) Man GlcNAc - a 1-acyl-2- a [peptide]-with 13 a (3R)-3- a (3R)-3- a very-long-chain 3-chloro-1- 2+ tetrakisphosphate 4-hydroxy- synthase, minor aminotransferase: synthase: 5-carboxymethylaminomethyluridineuridine- desulfurase:TUM1 Carbohydrate Degradation pyruvate (R)-2- 8 2 a [DNA]-3'- a peptide with a a 1-acyl-sn a uridine lauroyl-CoA NMN Cd YBR295W inositol-1,3,4,5- 3-kinase: ARG82 kinase: MSS4 imidazolecarboxiamide: isozyme: LEU9 BAT1 hydrogen sulfide N-acetylglutamyl- hydroxymethyltransferase: ammonia assimilation cycle I + oxidoreductase: ALD2 [tRNA] synthase: MSS1 MTO1 sulfurtransferase: TUM1 O-acetyl-L-serine hydroxyglutarate [protein] (isomer hydroxyl -glycerol arachidonoyl- a C-terminal in tRNA hydroxytetradecanoyl- hydroxydecanoyl- 2,3,4-saturated phenyl-1- tetrakisphosphate a 1-phosphatidyl- 5-methyl- D-myo-inositol HIS6 2-oxoadipate ILV2 ILV6 transaminase: ALT2 8A B ) leader sequence 3',5'-cyclic-nucleotidephosphatidylcholine L-arginine bifunctional [acp] IMP 5'- [acp] carbonyl putative fatty acyl CoA propanone BARrier to alpha- anthranilate phosphate 5-MTR-1-P SHM1 3-aminopropanal:NAD(P) a [3-mercaptopyruvate 1,2,3 1,3 (3R)-3- (3R)-3- very-long- 3-chloro-1- 6-kinase: ARG82 1D-myo-inositol 3(2H)- 1,3,4,5,6- branched-chain (S)-2-aceto-2- MethylthioRibose- alanine D-galactose degradation V (Leloir pathway) phosphodiesterase, DRAP nucleotidase: reductase thioredoxin the alpha AMD1: phoshatidylinositol-3- furanone phosphoribulosylformimino- 2-aminoadipate isopropylmalate amino acid phosphoribosyl L-proline biosynthesis + oxidoreductase: ALD3 sulfurtransferase]-S-sulfanyl-L-cysteine sucrose degradation III D-mannose (R)-2- RADiation putative monoacylglycerol hydroxyacyl- acyl-CoA hydroxyacyl- chain phenyl-1- 4,5-bisphosphate pentakisphosphate phosphoinositide- all-trans-farnesol transaminase: hydroxybutanoate transferase: TRP4 I (from L-glutamate) N-acetyl- 1-phosphate gly aminotransferase: bifunctional cysteine Changed acireductone (mannosyl) (N- signal peptidase cystathionine low affinity: PDE1 deaminase/ ISN1 (NADPH- peroxidase: enoyl-CoA propanone factor AMD1 phosphate 5-kinase: phosphatidylinositol reductase: AICAR-phosphate synthase: LEU4 transaminase: homoserine O- ammonium degradation hydroxyglutarate--pyruvate 8 sensitive: lipoate--protein putative lipase: MGL2 phospholipase carboxypeptidase [acyl-carrier- thioesterase: [acyl-carrier- H O inositol (1,3,4,5,6)- specific biosynthesis YER152C acetohydroxyacid O-acetylhomoserine γ-glutamyl- S-methyl-5-Isomerase: MRI1 ALT1 β-alanine β-D-galactopyranose synthase/O-acetylhomoserine Intracellular dioxygenase complex subunit: ferric-chelate gamma- high affinity cAMP tRNA protein] β-nicotinamide protein] dependent) SCO2 reductase: reductase: response: 2 ATG18 VAC7 4,5-bisphosphate 5- YNL134C pentakisphosphate BAT2 reductoisomerase: acetylglutamate acetyltransferase: tRNA-5- D-mannopyranose transhydrogenase: DLD2 Redox acetylglucosaminyl) DDC1 ligase: AIM22 monoacylglycerol D: SPO14 D: KEX1 ATF1 : ARI1 BAR1 Cco FIG4 VAC14 FAB1 phospholipase imidazoleglycerol- 2-aminoadipatee:2- (2S)-2- sulfhydrylase: glu phosphate MET2 thio-D-ribulose carboxymethylaminomethyluridine aminocarboxypropyltransferase: (Ni2+- α-1,2- MEC3 SPC3 SPC1 reductase: synthase: STR2 phosphodiesterase: pseudouridine dehydratase: D-ribonucleotide dehydratase: thioredoxin TSC13 GRE2 YPL130W 1-phosphatidyl- phosphatase: INP53 2-kinase: IPK1 ILV5 MET17 synthase: ARG2 reductase: 1-phosphate glutamine Inorganic Nutrient Metabolism galactose 6-phosphate MET17 (R)-2- state: CIR2 2 lipase: YJU3 PDE2 synthase: RIB2 acyl-CoA phosphatase: [+ 2 isozymes] peroxidase: O D-myo-inositol homofuraneol C: PLC1 IPP phosphate oxoglutarate isopropylmalate N-(5'-phosphoribosyl) putative 2-sulfurtransferase: SLM3 mutarotase: mannose-6- requiring): ADI1 mannosidase: MNL1 RAD17 SEC11 SPC2 FRE5 HTD2 HTD2 a peptide 2 1D-myo-inositol [+ 3 isozymes] inositol diphosphates biosynthesis [+ 2 isozymes] IPP (R)-2,3-dihydroxy- L-glutamate N- acetylglutamate ARG5,6 Methylthioribulose- synthetase: invertase: phosphate cysteine synthase: MCY1 hydroxyglutarate--pyruvate a 1-acyl-2- tRNA thioesterase: PHO8 a (2E)-dec- a ketone DOT5 aa -type 1,3,4,5,6- synthase: HIS7 aminotransferase: -anthranilate glutamate [+ 4 isozymes] 1-(β-D H O 3 isopropylmalate 3-methylpentanoate acetyltransferase: 1-phosphate GLN1 urea cycle GAL10 SUC2 transhydrogenase: DLD3an oxidized GMP arachidonoyl-choline 13 TES1 2 pentakisphosphate 3,5-bisphosphate Ins(1,2,3,4,5,6)P isomerase: ARO8 isomerase: TRP1 5-kinase: kinase: ARG5,6 N-acetyl-L- O-acetyl-L-homoserine a 5-carboxymethylaminomethyl- thiosulfate phosphate thiosulfate isomerase: ubiquinol-6 3-(methylsulfanyl) β-D- Man GlcNAc - L-homocysteine a fatty acid glycerol pseudouridine ribofuranosyl) 2-enoyl-[acp] cytochrome phosphatidylinositol 6 isomerase: LEU1 dihydroxy-acid ARG7 N-acetyl-L- DEhydratase: MDE1 34 α electron-transfer formate 7 2 a 2'- sn-glycerol an oxidized D-myo-inositol 1,3,4,5,6- IDI1 YHR033W glutamate 5- 2-thiouridine in tRNA disproportionation acquisition disproportionation -D-galactopyranose PMI40 mannopyranose[protein] (isomer a leader sequence synthase: PUS713 c oxidase 3,5-bisphosphate AICAR dehydratase: 1-(2-carboxyphenylamino)-1- glutamate 5-(methylsulfanyl) L-glutamate biosynthesis III acetate flavoprotein propanoate deoxyribonucleoside 2+ 3-phosphate a pseudouridine nicotinamide O c-type YKL163W pKC1 inositol (1,3,4,5,6)- pentakisphosphate deoxy-D-ribulose 5-phosphate semialdehyde III (rhodanese) I (thiol-dependent) F6P 7A B ) Fe 2 variant 2 5-phosphatase: 2-isopropylmaleate ILV3 gamma- gln acetylornithine -2,3-dioxopentyl L-methionine biosynthesis III 2-oxoglutarate 2-oxoglutarate 1,2,3 3 5'-monophosphate in tRNA H O YLL052C HcytochromeO Suppressor: pentakisphosphate 1-phosphate galactokinase: 2 2 KCS1 2-kinase: IPK1 ATG18 VAC7 indole-3-glycerol glutamyl aminotransferase: arginase: CAR1 GAL1 glucokinase: pKC1 inositol (1,3,4,5,6)- dimethylallyltransferase: L-2- isopropylmalate (3S)-3-methyl-2- phosphate kinase: ARG8 acireductone acid thiosulfate--thiol fructokinase: [+ 2 isozymes] FIG4 VAC14 FAB1 Suppressor: KCS1 pentakisphosphate ERG20 imidazole aminoadipate oxopentanoate carbamoyl- glutamate dehydrogenase phosphatase: GLK1 a diphospho- isomerase: LEU1 synthase: TRP3 PRO1 phosphate O-acetylhomoserine synthase: L-homoserine glutamate Ac/N-end rule pathway argininosuccinate bifunctional sulfurtransferase: HXK2 [+ 2 isozymes] a long-chain a 2'- a peptide with a [MAP kinase kinase]- a uridine 32 YFR022W [+ 2 isozymes] 2-kinase: IPK1 glycerol- reductase: LYS2 L-isoleucine:2- diphthamide biosynthesis acetylornithine UTR4 synthase: 1 (NADP-dependent): GDH1 lyase: ARG4 RhoDanese-Like DET1 RDL2 UDP-α-D-glucose methanethiol O-acetyl-L- a [protein]- a protein that ends protoheme a [peptide] with a (S)-2- carbonic acid a [protein]-L- YPR192W YBR200W-A 1D-myo-inositol geranyl phosphate synthetase: sulfhydrylase: MET17 an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- carbamoylphosphate fructokinase: D-glucopyranose L-cysteine fatty acyl-[acyl- a protein deoxyribonucleoside[DNA] an N-terminal aminobutanoate glu (L-serine/L-threonine) in tRNA dGTP methionine tetrakisphosphate a diphospho-1D-myo- [+ 2 isozymes] diphosphate oxoglutarate L-homocysteine hypusine biosynthesis acetyltransferase: homoserine O- GLT1 glutamate dehydrogenase synthetase/aspartate protein: RDL1 [+ 5 isozymes] sulfite HXK1 homoserine with an XCXC sequence carrier protein] 5'-triphosphate L-amino acid D glyceraldehydeC-terminal L-lysine mitogen- bifunctional peptide- putative inositol tetrakisphosphate dehydratase: aminotransferase: gamma- CPA1 CPA2 ARG7 2 (NADP-dependent): GDH3 L-methionyl-L- L-methionyl- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl- L-methionyl-L- thiosulfate phosphate 6-phosphate (3R)-3- glycerol-3- dGTP vacuolar ω,E,E-farnesyl HIS3 3-isopropylmalate acetyltransferase: alanyl-[protein] glycyl-[protein] seryl-[protein] threonyl-[protein] valyl-[protein] glutamyl-[protein] leucyl-[protein] isoleucyl-[protein] tyrosyl-[protein] transcarbamylase: URA2 reductase: YPR1 activated DRAP phosphate 1-O- methionine amidase: BAT1 cystathionine glutamyl carbamoyl glycine biosynthesis II methionine methionine methionine methionine methionine methionine L-glutaminyl- N-terminal N-terminal N-terminal L- N-terminal L- phenylalanyl- L-tryptophyl- N-terminal L- sulfurtransferase: glucose-6- bifunctional triglyceride lipase/ heme hydroxyacyl- cardiolipin carbonate diphosphatase: protease 2+ Ins(1,2,3,4,5,6)P diphosphate 3-(imidazol-4- dehydrogenase spermidine 2-(3-amino-3- L-ornithine N-acetyl-L- acireductone MET2 glu N-terminal [protein]N-terminal methionine N - methionine N [protein]- N-terminal L- [protein]N-terminal L- methionine N - carbamoyl-phosphate trehalose degradation bifunctional cysteine O-6-MethylGuanine- Rab prenyl protein- 3-oxohexanoyl- arginyl-tRNA- Ever Shorter vacuolar NADPH- glutamate- protein deaminase/ [acyl-carrier- acyltransferase: IsoCitrate (S)-S-oxide AMD2 Ca YEL031W pKC1 6 β-lyase: STR3 tryptophan phosphate phosphate glu aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: methionine N α - methionine N α - α α α TUM1 phosphate lysophosphatidylethanolamine oxygenases: carboxypeptidase YOL057W: synthase: dehydratase: NPP1 B: PRB1 YDR089W yl)-2-oxopropyl monomer: LEU2 branched-chain deoxyhypusine carboxypropyl) ornithine methionine N α - methionine N α - methionine N α - methionine N α - VI (periplasmic) synthase/O-acetylhomoserine Telomeres: aminopeptidase dependent alcohol kinase kinase tRNA Lyase: ICL2 reductase: amidase: Suppressor: synthase: L-2- cystathionine β- synthetase: TRP5 reductase: dioxygenase: O-acetyl-L- MAP2 MAP2 MAP2 MAP2 MAP2 MAP2 acetyltransferase: acetyltransferase: acetyltransferase: acetyltransferase: acetyltransferase: synthetase: CPA1 CPA2 isomerase: acyltransferase: TGL3 DNA geranylgeranyltransferase: specific [acp] protein HMX1 D: KEX1 -cysteine protein] SCT1 YOL057W CRD1 NCE103 [+ 2 isozymes] ERG20 phosphate aminoadipate (2S)-2-isopropyl- amino acid putative synthase: DYS1 histidine synthase: ADI1 homoserine acetyltransferase: acetyltransferase: NAT2 NAT2 MAK31 MAK31 acetyltransferase: acetyltransferase: MAK31 aminocarboxypropyltransferase: methylTransferase: BET2 BET4 MRS6 endoprotease: synthase: transferase: EST3 EST2 ysc1: APE1 dehydrogenase: ligase: kinase: SSK22 pseudouridine dehydratase: MXR1 NTA1 a peptide KCS1 a diphospho- pKC1 pKC1 pKC1 transaminase: cystathionine synthase: CYS4 PRO2 methionine methionine methionine methionine methionine methionine NAT2 NAT2 MAK31 MAK31 PGI1 α,α-trehalose MET17 TriacylGlycerol ADH6 synthase: RIB2 glycerol-3- 1D-myo-inositol Suppressor: KCS1 Suppressor: KCS1 Suppressor: KCS1 histidinol-phosphate reductase: LYS2 3-oxosuccinate a 2-[(3S)-3-amino-3-KTI11 DPH2 DPH1 4-(methylsulfanyl) an N-terminalMAK10 MAK3 MAK10 MAK3 an N-terminalMAK10 MAK3 ornithine thiocyanate sulfite MGT1 STE24 CEM1 ATE1 EST1 TLC1 GSH1 [+ 5 isozymes] HTD2 phosphate-O- dGMP gln BAT2 beta-lyase: indole ornithine aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: N-terminal N-terminal α MAK10 MAK3 MAK10 MAK3 α Lipase: TGL5 (Z,Z)- YGL006W 1D-myoinositol pentakisphosphate glutaminyl-tRNA Aminoacyl-tRNA Charging aminotransferase: L-glutamate-5- carboxypropyl]-L-histidine- -2-oxobutanoate O-acetylhomoserine MAP1 MAP1 MAP1 MAP1 MAP1 MAP1 N-terminal N-terminal methionine N - methionine N N- -acetyl-L- N -acetyl-L- arginosuccinate carbamoyltransferase: ARG3 a geranylgeranylated D-glyceraldehyde tRNA a (2E)-octadec- acyltransferase: glycerol succinate HIS5 allysine YHR112C deoxyhypusine semialdehyde carbamoyltransferase: an N-terminal L- an N-terminal α α [+ 3 isozymes] biliverdin-IX α lys 2-enoyl-[acp]32 a peptide TOS6 5-diphosphate 1D-myo-inositol 3- 1D-myoinositol 5- 1D-myo-inositol 1- biosynthesis via transamidation [translation elongation factor 2] cystathionine sulfhydrylase: glycine methionine N α - methionine N α - methionyl-L- methionyl-L- synthetase: ARG1 protein that ends a peptide γ pseudouridine GPT2 L-asparagine methionine- aminomethyltransferase: gly L-seryl-[protein] acetyltransferase: acetyltransferase: trehalase: ATH1 met a [protein]-S- a [protein] C-terminal Arg -L-glutamyl-(S)- 1-arachidinoyl- 1,2,3,4,6- diphosphate 1,2,4,5,6- diphosphate 1,2,3,4,6- diphosphate 2,3,4,5,6- (2E,6E)- L-histidinol cysteine-S- synthase: DYS1 tryptophan diphthine ARG3 β-lyase: STR3 cystathionine β- MET17 dehydrogenase alanyl-[protein] an N-terminal-acetyltransferase: acetyltransferase: leucyl-[protein] tyrosyl-[protein] L-citrulline with a XCXC sequence a tripeptide a long-chain 3- a tRNA synthase: PUS9 farnesyl saccharopine conjugate beta- biosynthesis I oxo-acid GCV1 α MDM20 NAT3 MDM20 NAT3 methyl-L-cysteine S-farnesyl-L-cysteine 2-aminobutanoate sn-glycerol 2+ 2+ pentakisphosphate pentakisphosphate pentakisphosphate pentakisphosphate phosphate dehydrogenase 4-methyl-2- synthetase: TRP5 synthase: DPH5 synthase: CYS4 (decarboxylating) N-terminal alanine N N-terminal N-terminal glycine N N-terminal serine N N-terminal N-terminal valine NN -acetyl-L-MDM20 NAT3 MDM20 NAT3 oxoacyl-[acp] Ca YNL291C Ca diphosphate gln oxopentanoate lyase: IRC7 putative transaminase: : GCV2 -acetyltransferase: cysteine N - -acetyltransferase: -acetyltransferase: threonine N - -acetyltransferase: bifunctional UDP-glucose all-trans-retinol a fatty acid 3-phosphate (NADP+, L- cystathionine beta- AAT2 α α α α α α methionyl-L- diphosphoinositol- diphosphoinositol 3-diphosphoinositol diphosphoinositol phosphatase: histidinolphosphatase: L-leucine:2- asp L-homocysteine a [glycine-cleavage a [glycine-cleavage NAT5 ARD1 NAT1 acetyltransferase: NAT5 ARD1 NAT1 NAT5 ARD1 NAT1 acetyltransferase: NAT5 ARD1 NAT1asparaginyl- Detoxification 4-epimerase/aldose YBR056W PHO8 glutamate HIS2 glutamate- L-cystathionine asparagine lyase: YHR112C 6 6 an N-terminal an N-terminal mannose 1-epimerase: GAL10 pentakisphosphate pentakisphosphate pentakisphosphate diphosphoinositol diphosphoinositol pentakisphosphate oxoglutarate cystathionine deoxyhypusine trp complex H protein] Ncomplex H protein] N NAT5 ARD1 NAT1 α NAT5 ARD1 NAT1 α 6 2+ synthase: forming): LYS9 [protein] 6 37 β-D-glucopyranose a protein with a [1-Cys a [histone H3] N β 2,5-diamino-6- a kinesin- YOR087W Ca kinase: VIP1 5-kinase: KCS1 5-kinase: VIP1 5-kinase: KCS1 serine biosynthesis gamma- synthase cysteine-S-conjugate -dihydrolipoyl-L-lysine an N-terminal N -acetyl- N -acetyl-L- degradation 6 6 cholesteryl- - lysine within sn-glycerol a dolichyl pentakisphosphate pentakisphosphate GLT1 aminotransferase: synthase: DYS1 pyrroline-5- methylated diphthine 5-methyltetrahydropteroyltriglutamate--homocysteine -[(R)-lipoyl]-L-lysine α N -L-threonylcarbamoyladenosine glutathione-mediated detoxification II glycerophosphoglycerol L-glyceraldehyde (R)-lipoate (5-phospho-D- microtubules histidinol BAT1 from glyoxylate lyase: CYS3 cystathionine carboxylate (glutamine- beta-lyase: IRC7 N -acetyl-L- glycyl-[protein] valyl-[protein] arsenic detoxification (yeast) reactive oxygen species degradation reduced L- peroxiredoxin]- ,N ,N -trimethyl- D-glucoside asp O-ureido-L- cys gcv protein H 1-phosphate dATP diphosphate 5-kinase: KCS1 5-kinase: KCS1 gamma- methylhydrolase: arginosuccinate S-methyltransferase: MET6 -modified tRNA biosynthesis UDP-glucose:hexose- UDP-glucose D-mannopyranose cysteine residues (S-hydroxy-S L-lysine-36 homoserine L glyceraldehyde Meiotic and ribosylamino) complex putative pyridoxal 5'- histidinol cystathionine γ- reductase: RRT2 hydrolyzing) cysteinyl-[protein] 1-phosphate reductase: YPR1 1D-myo-inositol 4- (3R)-3- 2-deoxyglucose- KInesin glycerol-1- dATP peptide- phosphate branched-chain lyase: CYS3 synthetase: ARG1 RX mannokinase: -oxocysteine) monophosphate Centromere pyrimidin- related phosphatase: amidase: CAX4: 2+ 2+ phoS dehydrogenase: saccharopine amino acid synthase: STR2 PRO3 : ASN1 L-cystathionine uridylyltransferase: 4-epimerase: phosphatidylglycerol cholesteryl-β- putative S-methyl-5- 2,5-diamino-6- hydroxyacyl- 6-phosphatase: methionine Ca YGR217W Ca synthase: glu L-alanine a diphthine-[translation cystathionine met thr GAL10 HXK1 [histone-H3]- Rab protein metallo- NADPH- phosphatase: INM1 regulatory 4(3H)-one [acyl-carrier- DOG2 Protein: GPP1 diphosphatase: (R)-S-oxide AMD2 CAX4 a bis(diphospho) HIS4 dehydrogenase transaminase: serine [+ 2 isozymes] deoxyhypusine glycine biosynthesis asparagine glutathione GAL7 D-xylose trimethyl-L- phospholipase C: PGC1 D-glucosidase: argininosuccinate cystathionine beta- lipoate-- thioadenosine ser, tyr- (ribosylamino) NPP1 3,5-bisdiphosphoinositol- SNZ3 SNO3 biosynthesis III elongation factor 2] synthase gamma-lyase: CYS3 cystathionine dihydrolipoamide L-threonylcarbamoyladenylate transferase: superoxide α mannokinase: SulfiRedoXin: geranylgeranyltransferase: farnesyltransferase: tRNA aminopeptidase: synthase: ARG1 dependent alcohol synthase: CYS4 INositol phosphorylase: -4(3H)- protein] 2-deoxyglucose- KIP2 glycerol-1- reductase: amidase: -1D-myo-inositol 1D-myo-inositol 2,3,4,6- (NAD+, L-lysine- BAT2 hydroxymethyltransferase: synthase: DYS1 from glyoxylate cystathionine γ- dehydrogenase: synthase: SUA5 arsenate:sodium dismutase: -D-glucopyranose UDP-α-D-galactose HXK2 degradation II fructose degradation SRX1 lysine-36 glycerophosphodiesterase: BET2 BET4 MRS6 deoxyribodipyrimidine RAM2 RAM1 ligase: EGH1 APE2 dehydrogenase: protein Kinase: MCK1 [+ 2 isozymes] a dolichyl pyridoxal 5'- forming): LYS1 SHM2 diphthamide argininosuccinate (glutamine- gamma-lyase: CYS3 GTT2 1-phosphate D-mannopyranose photo-lyase: PHR1 ligase: AIM22 Monophosphatase: MEU1 pyrimidinone dehydratase: 6-phosphatase: [+ 2 isozymes] phosphatase: MXR2 NTA1 phosphatechloride tetrakisphosphate tetrakisphosphate synthase: RRT2 synthase: STR2 LPD1 symporter: PHO87 SOD1 demethylase: GDE1 TRL1 ADH6 INM2 [+ 3 isozymes] 5'-phosphate HTD2 GPP2 YOR003W phosphate glycine cys glyoxylate lyase: ARG4 hydrolyzing) glutathione 6-phosphate a [1-Cys RPH1 a [protein] L- 2,5-diamino-6- DOG1 YBR235W YHL008C histidinol [+ 2 isozymes] 6 [+ 2 isozymes] phosphoglucomutase: D-xylose a geranylgeranylated cholesterol reductase: RIB7a (2E)-dodec- 2-deoxy- synthase: lys hydroxymethyltransferase: L-cysteine alanine--glyoxylate diphthine--ammonia : ASN2 N -L- transferase: mannose-6- a farnesylated (5-phospho- + SNZ2 SNO2an L-glutamyl- dehydrogenase: arsenous acid PGM1 reductase: YPR1 fructokinase: HXK2 peroxiredoxin]-(S a protein with glycerol sn-glycerol protein that ends protein that a proteinogenic L-cystathionine serine phosphate 2-enoyl-[acp] D-glucose K Gln HIS4 SHM1 Ligand of desulfurase: aminotransferase: ligase: DPH6 arg threonylcarbamoyladenine GTT1 hydrogen phosphate amino acid D-ribitylamino) [tRNA ] peroxide phosphoglucomutase: [+ 2 isozymes] fructokinase: HXK1 -hydroxycysteine) a disulfide bond formaldehyde succinate 3-phosphate with a XXCC sequence ends with a adenine pyrimidin- YJR040W chloride pyridoxal 5'- ser eIF5A: LIA1 NFS1 ISD11 AGX1 a diphthamide-[translation synthase: KAE1 BUD32 [+ 2 isozymes] isomerase: F6P phosphate glutaminyl- ala elongation factor 2] CGI121 GON7 PCC1 low-affinity PGM2 PMI40 xylitol CaaX sequence 4(3H)-one YOR382W YOR104W synthase: tRNA glucose/ catalase: glutathione synthase putative N(6)-L- CTT1 peroxidase: D-glucopyranose palmitate biosynthesis (cytoplasm) Fatty Acid and Lipid Biosynthesis SNO1 SNZ1 threonylcarbamoyladenine cytoplasmic mannose 6-phosphate 4α-methyl- an N-terminal a (1->4)- a nucleoside (R)-4-hydroxy- superpathway of ergosterol biosynthesis I superpathway phosphatidate biosynthesis (yeast) phospholipid remodeling (phosphatidate)acyl-CoA phosphatidylinositol phosphatidylserine and (glutamine- transporter catalase GTT1 a ferrocytochrome a ferrocytochrome α an L-arginyl- a supercoiled duplex DNA sn-glycerol citrate GMP synthase: QRI7 glutathione ATP- arsenate 5 -cholesta- 3-sulfo-L- Arg a tRNA precursor a myristoyl-[acp] α-D-glucan cyclic 3',5'- ATP 4-methyl-2- hydrolysis biosynthesis II (eukaryotes) phosphatidylethanolamine synthase: hydrolysing) 6 HXT1: HXT1 A: CTA1 [+ 3 isozymes] b b β [tRNA ] 3-phosphate an acetoacetyl-[acp domain an N -L- S-conjugate dependent reductase: 5 5 8,24-dien-3 -ol alanyl-[protein] CTP putative helicase: monophosphate D-galactose oxoglutarate bifunctional aconitate Synthetic YBL008W-A (2E,6E)-farnesyl diphosphate lanosterol acetyl-CoA DHAP a 2,3,4-saturated a CDP- biosynthesis I GUA1 : PET112 37 high affinity cAMP reductase: GRE3 acetylornithine bifunctional 4- enoyl-[acyl- glycerol-1- within a fatty acid synthase] myo-inositol a CDP- HER2 GTF1 tRNA charging threonylcarbamoyladenine carboxypeptidase: vacuolar ARR2 glycerol YLR419W IsoMAltase: phosphodiesterase: DRAP carrier- phosphatase: hydratase: pyrroline-5- Lethal farnesyl- acetyl-CoA C- fatty acyl CoA diacylglycerol [+ 8 isozymes] in tRNA PRC1 transporter uptake/ O H O NADPH- transaminase: putative acyl-CoA hydroxy-4-methyl- bis(5'-adenosyl)- allophanate ACO2 of N-end acyl-CoA:lyso- acyl-CoA diacylglycerol 2 2 dihydroceramide C-4 methyl CCA tRNA TFIIH/NER complex IMA2 PDE2 FMN deaminase/ methionine protein] GPP1 carboxylate diphosphate:farnesyl- acyltransferase: POT1 phosphatidylserine YCF1: YCF1 efflux Alcohol Degradation arginyltransferase: 3-oxohexanoyl-[acp] dependent alcohol ARG8 carboxylic ester thioesterase: 2-oxoglutarate triphosphatase: hydrolase: rule: SLN1 YDL245C glycerol 3- dihydroxyacetone phosphatidate thioesterase: Met Lys Trp Tyr glutathione C4-hydroxylase: sterol nucleotidyltransferase: peptide:N- ATPase/helicase [+ 6 isozymes] 3',5'-cyclic-nucleotide an [amino-group carrier adenylyltransferase: aldolase/ tRNA aminopeptidase: reductase: glycerol-1- aconitase: reductase: a [protein]- diphosphate 30-hydroxylanosterol acetyl-CoA phosphatidylinositol synthase: CHO1 ammonium elongator tRNA a tRNA glu trp a tRNA tyr a tRNA facilitator ATE1 synthase: CEM1 dehydrogenase: FAD1 hydrolase: DDL1 TES1 pseudouridine HNT2 DUR1,2 phosphate phosphate acyltransferase: ALE1 ATF1 Asn Ala Gly tRNA methylation S-conjugate glutathione SUR2 oxidase: CCA1 glycanase: subunit: TFB2 TFB5 protein]-C-terminal-γ-(L- MAP1 ETR1 ACO1 PRO3 N-phospho- a (3R)-3-hydroxybutanoyl- farnesyltransferase: acetyltransferase: phosphatidate biosynthesis dehydrogenase: oleoyltransferase: synthase: PIS1 a phosphatidylserine asn tRNA a tRNA ala a tRNA protein arsenate detoxification ethanol degradation II phosphodiesterase, ADH6 [+ 2 isozymes] oxaloacetate synthase: RIB2 a (2E)-dodec- phosphatase: Hyp oleoyl-CoA: acyl-CoA Ile carboxypeptidase: S-conjugate ethylene glycol glycerol Polymeric Compound Degradation ERG25 PNG1 TFB4 SSL1 RAD3 low affinity: PDE1 glutamate 5-semialdehyde- decarboxylase: 38- [+ 2 isozymes] GPP2 D-threo-isocitrate L-histidine [acp domain within ERG9 ERG10 arg a tRNA leu 48 37 glycerophosphodiester degradation γ a pseudouridine II (the glycerol-3- GPD1 SCT1 glutaminyl- 49 40 34 34 34 10 4 4 44 58 ATG42 transport: FPS1: TFB1 TFB6 SSL2 D-glucopyranosea nucleoside 5'- D-galactopyranose 2-yl)-L-glutamate di-homo- - 2-enoyl-[acp] 2+ a fatty acid synthase] presqualene diphosphate acetoacetyl-CoA lysophosphatidate thioesterase: a 1-phosphatidyl- phosphatidylserine Val Mitochondrial aminoacyl- Met ser Mitochondrial aminoacyl- Mitochondrial aminoacyl- Mitochondrial aminoacyl-W (tryptophan) RS Mitochondrial aminoacyl- Mitochondrial aminoacyl- a cytosine a cytosine a cytosine in a cytosine in a guanosine a carboxymethyluridine a guanine a cytidine an adenosine a uridine an adenine guanine degradation degradation I a (C18)- Arg a tRNA YER010C ammonium glycerol 2+ Zn phosphate pathway) a tRNA initiator tRNA met a tRNA gln his Pro His ser Phe FPS1 linolenate 40 in tRNA Zn [+ 2 isozymes] dihydroxyacetone TES1 tRNA 26 in tRNA2 49 in tRNA5 48 tRNA5 precursor 40 tRNA5 precursor 34 in tRNA5 32 in tRNA in tRNA 10 2 4 Gly in tRNA Ser in tRNA 58 in tRNA1 Phe 37 YBT1 arsenate arsenite 4α-carboxy- a tRNA containing a KIN28 CCL1 TFB3 monophosphate transporter (3R)-3- acyltransferase: a 2,3,4-saturated 1D-myo-inositol decarboxylase: PSD1 tRNA Synthetase, asparagine--tRNA tRNA Synthetase, putative alanine--tRNA tRNA Synthetase, tRNA Synthetase, (tRNA synthetase): WRS1 tRNA Synthetase, tRNA Synthetase, Glycyl-tRNA tRNA (guanine -N ) tRNA (cytosine -C )tRNA (cytosine -C ) tRNA (cytosine -C ) tRNA (cytosine -C ) tRNA (cytidine / tRNA tRNA (guanine -Nin tRNA)- 4 cytidine in tRNA in tRNA 4 tRNA tRNA (adenine -N ) tRNA (guanine -N glycogen degradation II phytoceramide benzyl alcohol pyruvate synthase cytidine in adenosine in 1 a glycerophosphodiester chitin deacetylation α a ferricytochrome 2+ 2+ hydroxyacyl-[acyl- presqualene hydroxymethylglutaryl- phosphate TGL4 Methionine: MSM1 ligase: DED81 proline--tRNA arginine--tRNA ligase: MSR1 Threonine: MST1 ligase: YNL040W lysine (K): MSK1 Glutamate (E): MSE1 Mitochondrial aminoacyl- Isoleucyl tRNA Synthetase tyrosine (Y): MSY1 Mitochondrial aminoacyl-Cell Division Cycle: CDC60 Phenylalanine (F): MSF1 Synthase: GRS2 34 34 Pro His 44 ABC-type cytoplasmic arsenite/ alcohol ethylene glycol 5 -cholesta- 3' CCA end a single stranded DNA met Mg YOL130W Mg fatty acid phosphatidylserine (glutamine- -methyltransferase: -methyltransferase: -methyltransferase: -methyltransferase: -methyltransferase: guanosine -2'-O)- (carboxymethyluridine monomethyltransferase:- tRNA 2'-O- (GCC) 2'-O- tRNA 2'-O- (uridine -2'-O)- -methyltransferase: )-methyltransferase: + glycerophosphodiesterase: b YKR013W CoA synthase: ERG13 glycerol 3-phosphate acyltransferase: 2 1 1 glutathione- arsenate antimonite:H dehydrogenase glycolaldehyde glycerol 8,24-dien-3β-ol 5 carrier-protein] diphosphate:farnesyl- oleoyl- decarboxylase: PSD2 hydrolysing) VAlyl-tRNA MEthionyl-tRNA methionine--tRNA serine--tRNA ligase: DIA4 asparagine--tRNA ligase: YHR020W arginine--tRNA THreonyl tRNA ALAnyl-tRNA Lysyl (K) tRNA GlUtamyl-tRNA tRNA Synthetase, GLutamiNe of Mitochondria: ISM1 TYrosyl-tRNA tRNA Synthetase, Nuclear Accommodation Histidine-Trna phenylalanyl (F)-tRNA Glycyl-tRNA an N TRM1- NCL1 a 5- NCL1 NCL1 40 NCL1 methyltransferase: 5-O)-methyltransferase: TRM112 TRM11 methyltransferase: methyltransferase: methyltransferase: methyltransferase: an N GCD10- GCD14 an N TRM5- GDE1 dehydrogenase: GPD1 GPT2 YNL247W: YNL247W 26 48 a 5 methylcytosine 58 37 S-conjugate reductase: antiporter: IV: ADH4 reductase: kinase: chitin NADH YNL055C NADH dehydratase: diphosphate CoA:lysophosphatidatedioleoyl : PET112 Synthetase: VAS1 Synthetase: MES1 ligase: MSM1 serine--tRNA ligase: SES1 ligase: SLM5 proline--tRNA ligase: AIM10ligase: YDR341C Synthetase: THS1 synthetase: ALA1 Synthetase: KRS1 Synthetase: GUS1 tryptophan (W): MSW1 metabolism: GLN4 isoleucine--tRNA ligase: ILS1Synthetase: TYS1 Aspartate (D): MSD1 of Mitochondria: NAM2 Synthetase: HTS1 Synthetase: FRS2 FRS1 Synthase: GRS1 methylguanine methylcytosine a 2'-OTRM7- a 5-(2-methoxy-TRM9 TRM112 TRM13 a 2'-O-TRM13 TRM13 a 2'-OTRM44- methyladenine methylguanine phosphatidylglycerol L-cystine YCR075C L-cystine HTD2 HMG-CoA [+ 2 isozymes] in tRNA precursor 34 4 44 Phe transporter: ARR2 ARR3 ethanol YLL056C GUT1 glycogen chitin farnesyltransferase: 1-oleoyl-2- acyltransferase: TGL5phosphatidate HER2 GTF1 in tRNA in tRNA methylguanosine 2-oxoethyl) methylcytidine methyluridine in tRNA in tRNA arsenous acid phospholipase C: PGC1 GDP-α-D- an N-terminal (R)-N-formyl-β- D-glyceraldehyde a 5'-triphospho- 4α-methyl- ERG9 4,4-dimethyl-5-α-cholesta- sn-glycerol 3-phosphate glycerol-3- 2 34 ser BPT1 dehydrogenase: phosphorylase: deacetylase: CDA1 an MPP-processed NADPH an oxidized a glycogen maltotriose isobutyl acetate GDP 3-hydroxy- lyso-glycerone oleoyl- lipase: TGL4 Val Met ser Ala Cys Trp Ile Tyr Leu Phe Gly tRNA (N - in tRNA uridine in tRNA in tRNAGly(GCC) in tRNA mannose GGPP 3-sulfino-L- ser 3-phosphate purine-[mRNA] L-allo-threonine 5α-ergosta- a protein Zn 2+ 8,14,24-trien-3-β-ol phosphate 1-O- an L-valyl-[tRNA an ]L-methionyl-[elongator tRNA ] an L-seryl-[tRNA ] an L-alanyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-leucyl-[tRNA ] an L-phenylalanyl-[tRNA a glycyl-[tRNA] ] 26 2 ADH2 GPH1 chitin mitochondrial protein adrenodoxin hydroxy-L-kynurenine borate 2+ YOR316C 3methylglutary-CoA phosphate CoA:lysophosphatidate methylguanine -N ) arsenous acid aldehyde alanyl-[protein] glyceraldehyde polynucleotide inositol guanosine tRNA- delta(14) 8,14,24(28) YML116W Co squalene glycerol-3-phosphate-O- oleoyltransferase: phospholipid remodeling (phosphatidylethanolamine) an L-glutaminyl- a glutathione- glycerol-3- α deacetylase: CDA2 β vacuolar acetate C-14 sterol reductase: HMG2 acyltransferase: GPT2 acyltransferase: SLC1 Gln -methyltransferase: dehydrogenase: glycerol-3-phosphate an -limit dextrin glucan 1,4-alpha- NADPH--hemoprotein 3-phosphate 5'-phosphatase: polyphosphate diphosphatase specific -sterol -trien-3delta(14)-ol SCT1 [tRNA ] TRM1 S-conjugate phosphate acetate dolichyl-phosphate beta- adrenodoxin- arylformamidase: IsoMAltase: Uracil DNA N- isoamyl dehydrogenase: CTL1 acylglycerol isobut acetate of Golgi adenosine -sterol proteinase squalene,hydrogen- reductase: ERG24 3-hydroxy-3- glycerol-3-phosphate 1- 1-acyl lysophosphatidic acid lysophosphatidylcholine palmitoleate Glycolysis aldehyde ALD4 dehydrogenase: GUT2 protein arginyltransferase: octapeptidyl amino- carboxypeptidase: glucosidase: IMA2 reductase: NCP1 Glycosylase: L-allo- 5-phosphatase: reductase: YIR028W donor:oxygen methylglutaryl-CoA glycerol-3- dihydroxyacetone acyltransferase: ICT1 acyltransferase: TAZ1 biosynthesis glutathione aldehyde dehydrogenase: bifunctional 4-alpha- D-mannosyltransferase: tryptophan NADP SGA1 BNA7 acetate TDH2 mRNA 5'- lipase: YJU3 esterase: IAH1 INP54 membrane: GDA1 deaminase ERG24 reductase: A: PEP4 O-acyltransferase: SCT1 1-18:1-2-18:1-phosphatidylethanolamine Activation/ Pentose Phosphate Pathways dehydrogenase: GUT2 glucanotransferase/ acetyl CoA DPM1 geranylgeranyltransferase ATE1 peptidase: OCT1 CPS1 synthetase: [+ 6 isozymes] UNG1 esterase: threonine α borate borate YDL049C oxidoreductase (2,3- 14-demethyllanosterol reductase: HMG1 phosphate O- phosphate oleoyl-CoA: acyl-CoA:lyso- Fermentation Transport Inactivation/ S-conjugate ALD4 dehydrogenase synthetase: ACS2 type I complex: CDC43 RAM2 reductase: [+ 2 isozymes] triphosphate aldolase: [+ 3 isozymes] subunit: 4 -methyl-ERG24 YMR279C a butanoyl-[acp domain acyltransferase: palmitoyl-CoA glycolysis III (from glucose) γ-glutamate amylo-alpha-1,6- TRP5 ARH1 IAH1 3-phospho- TAD1 5α-ergosta- acetate acetate a factor YKL209C a factor epoxidizing): ERG1 a 2-lysophosphatidate reductase: AYR1 lysophosphatidate phosphatidylethanolamine Carbohydrate Biosynthesis Interconversion arsenite aldehyde (NAD+): ALD5 DHAP acetyl CoA β-D-mannosyl- phosphatase: GLY1 Ins(1,4)P 37 within a fatty acid synthase] 4,4-dimethylzymosterol,NAD(P) GPT2 phospholipase A2: TGL4 palmitoyl-CoA Nucleoside and Nucleotide Biosynthesis pentose phosphate pathway glycolysis TCA cycle TCA cycle II (plants and fungi) hydrolase: glucosidase: GDB1 D-glucopyranose an apyrimidinic D-glycerate glycerol 2 a hypoxanthine 8,24-dien-3β-ol acyltransferase: acyltransferase: ALE1 pyruvate fermentation dehydrogenase aldehyde:NAD+ ω maltose CET1 acetate isobutanol ala (3S)-2,3-epoxy-2,3-dihydrosqualene H:oxygen oxidoreductase lysophosphatidic acid superpathway of acetoin and butanediol biosynthesis carnitine shuttle thiamin synthetase: ACS1 (C55 -saturated a geranylgeranylated Arg a fully-processed D-glyceraldehyde in tRNA 9-desaturase: to ethanol II pyruvate D-glucopyranose ECM38 arsenite/ arsenic a tRNA an amino acid + + site in DNA a diphospho-5'- (hydroxylating): ERG25 LOA1 oleoyl- protein N-glycosylation (eukaryotic) initial steps protein O- GDP-mannose biosynthesis superpathway of purine nucleotides de novo biosynthesis I triphosphate + ATP- (NAD+): ALD5 oxidoreductase: dolichyl protein that ends mitochondrial protein 3-phosphate NADP H a reduced acetate purine-3'-[mRNA] YKL217W YDR040C mevalonate acyltransferase: LOA1 CoA:lysophosphatidylethanolamine OLE1 gluconeogenesis glucose-6- Aromatic Compound Biosynthesis pyrimidine deoxyribonucleotides superpathway of pyrimidine deoxyribonucleotides xanthine and fermentation antimonite:H triglutathione ALD3 acetyl-CoA phosphate) adrenodoxin YJL078C lanosterol kinase: ERG12 lysophosphatidic acid stearate biosynthesis palmitoleoyl-CoA mannosylation I (yeast) pyrimidine pyruvate acetyl-CoA metabolism glucokinase: antiporter: dependent acetate (R,R)-butanediol with a CaaL sequence gly synthase: ERG7 1-oleoyl-sn-glycerol 3-phosphateacyltransferase: TGL3 lysophospholipase: NTE1 malate phosphate biosynthesis from CTP adenosine nucleotides de novo biosynthesis I xanthosine salvage ribonucleosides to (R)-acetoin I aldehyde:NAD+ degradation α acyltransferase: ICT1 a dolichyl phosphate D-glucopyranose biosynthesis PRPP pyruvate carboxy- glucose-6- GLK1 glucose-6- ARR3 vacuolar debranched glucan 1,4- - malate (R)-5-phosphomevalonate a palmitoyl-[acp lyso-phosphatidylethanolaminelipase: acyl-CoA (S)-malate dehydrogenase: 6-phosphate chorismate biosynthesis CTP de novo biosynthesis I UDP CTP salvage III [+ 2 isozymes] phosphate transporter an arsenite-[arsenite acetyl CoA oxidoreductase: limit dextrin glucosidase: 4α-hydroxymethyl- 1-acyl-sn-gylcerol- glucose-6- D-glucopyranose 4-hydroxybenzoate 4-hydroxyphenylpyruvate cytidine lyase: PDC6 acetolactate phosphate citrate synthase: CIT3 methyltransferase] synthase: MLS1 acetate YCR010C acetate 4β-methyl-5α- 3-phosphate acyl 1-oleoyl-sn domain within a PLB2 thioesterase: dolichyl- MAE1 phosphoribosylpyrophosphate UDP reductase: nucleoside- pyruvate carboxy- peroxisomal dehydrogenase: D-glucopyranose isomerase: malate [+ 2 isozymes] YCF1: YCF1 synthetase: ACS2 ALD2 phosphorylase: SGA1 10 Man GlcNAc - a peptide with 1D-myo-inositol 1- 1575 a 1,2-diacyl- a protein β-D-glucose phosphomevalonate TES1 phosphate glucokinase: biosynthesis I (eukaryotes) biosynthesis nucleoside- cytidine pyruvate synthase: (R,R)-butanediol an L-methionyl- an N - 8 2 S-(2-hydroxyacyl) a guanine ethanol D-mannitol a decanoyl-[acyl- a RAD21 YBR053C β -glycerol 3- fatty acid synthase] lyso-phosphatidylethanolaminelipase: UDP-N-acetylglucosamine--dolichyl- phosphate RNR2 triphosphatase: lyase: PDC6 carnitine O- PGI1 dehydrogenase: 8-oxo-(d)GTP detoxification I acetyl CoA GPH1 Met [protein] (isomer H O an N-terminal diphosphate 2,3,4,5,6- sn-glycerol 3- with incorrect a protein YMR251W-A cholesta-8,24-dien-3 - kinase: ERG8 transferase: SLC1 isomerase: GLK1 amidotransferase: ADE4 triphosphatase: nucleosidase: decarboxylase: PDC5 ILV2 ILV6 pyruvate ZWF1 6-phosphate glycolate dehydrogenase: [initiator tRNA ] formyltetrahydrofolate 2 GTP glutathione in 18S tRNA carrier protein] cohesin subunit 6-phosphate ol,NAD(P)H:oxygen phosphate PLB1 phosphate N- mannose pyruvate 3-deoxy- RNR4 RNR1 FAP7 pyruvate acetyltransferase: thiamine 6-phospho MAE1 an L-cysteine- synthetase: ACS1 D-glucopyranose 8A B ) Xaa-L-proline pentakisphosphate diadenosine and 18S rRNA medium-chain fatty trifunctional histidinol ARGRIII inositol mannitol 2- diphosphate Suppressor disulfide bonds 3-keto- inositol-3- acyl-CoA:lyso- PGI1 [+ 2 isozymes] tyr gly FAP7 URH1 pyruvate carboxy- decarboxylase: PDC1 CAT2 glucose-6- citrate BDH1 α-D- malate 1,2,3 1,3 diadenosine and 1575 7 dehydrogenase: diacylglycerol EPS1: enoyl-[acyl- + oxidoreductase lysophospholipase: PLB3 acetylglucosaminephosphotransferase: synthase: cytosolic malate D-arabine- CTP decarboxylase: PDC5 diphosphate D-glucono- [+ 3 isozymes] S-conjugate a methylarsenite- β diphosphoinositol (guanine -N )- acid ethyl ester dehydrogenase/ polyphosphate protein-serine/ of SNf1: saaccharolysin: carrier- steroid separase: phosphate YJL129C K (R)-mevalonate diphosphate phosphatidate ALG7 DPM1β dehydrogenase: L-tyrosine:2- L-tyrosine:2- CTP adenylosuccinate xanthine lyase: PDC1 pyruvate [+ 2 isozymes] kinase 1,5-lactone phosphate aconitate acetyl-CoA (R)-acetoin glucopyranose dehydrogenase: cystathionine hydroxyacylglutathione diphosphoinositol ergosteryl- -D- synthase: EHT1 phosphoribosyl- MAN2 pyrophosphate EPS1 dolichol and dolichyl (hydroxylating): ERG25 a dolichyl - pyruvate heptulosonate- oxoglutarate diphosphatase: dUDP diphosphatase: decarboxylase: PDC5 pyruvate carboxy- isomerase: phosphofructokinase: hydratase: ACO1 cysteine-S [arsenite GTP 1-phosphate MAE1 methionyl-tRNA initiation-specific α-1,6- putative ribonuclease hydrolase: GLO2 aminopeptidase polyphosphate glucosidase: polyphosphate methyltransferase: multikinase: threonine phosphatase: SSN8 SRB8 PRD1 protein] reductase: ESP1 synthase: acyltransferase: MDH2 mannose-6- oxoglutarate synthetase: ADE12 cytosine lyase: PDC1 glucokinase: gamma- BUD237 TRM112 medium-chain fatty AMP cyclohydrolase/ ARG82 mannitol 2- [+ 4 isozymes] ERG27 INO1 YKR055W phosphate biosynthesis 4α-formyl-4β-methyl-5α- mevalonate diphosphate fatty acid α D-mannosyl carboxylase: 7-phosphate aminotransferase: aminotransferase: phosphoribosylglycinamidine YND1 kinase: YNK1 YND1 xanthine pyruvate 6-phosphogluconolactonase: PGI1 PFK1 PFK2 aconitate -conjugate methyltransferase] formyltransferase: mannosyltransferase: GTPase: LSG1 III: RNT1 yscII: APE2 phosphohydrolase: EGH1 phosphohydrolase: an N - phosphatase: DPP1 SSN2 SSN3 reductase: 4α-methyl- (3R)-3- ALE1 N-acetyl- -D-glucosaminyl- malate phosphate phosphoribosyl deaminase: alcohol dehydrogenase SOL4 FMT1 synthase: STR2 glyoxylase- 1575 phosphoribosyl-ATP dehydrogenase: + cholesta-8,24-dien-3β-ol decarboxylase: MVD1 activation glycerophosphodiester phosphate PYC1 synthase: ARO3 3-(4- ARO8 synthetase: ADE5,7 dUTP decarboxylase:acetoin PDC6 synthase: PDC6 coenzyme A fumarate hydratase: ACO2 β-lyase: phosphoglucomutase:GLK1 OCH1 [+ 11 isozymes] II: GLO4 DDP1 D-myo-inositolDDP1 methylguanine acid ethyl ester CDC55 diacylglycerol phospho-[DNA-[+ 2 isozymes] a peptide ETR1 5α-cholesta- a peptide Ins(3)P YKR050W K hydroxyacyl-[acyl- (2E,6E)-farnesyl oleoyl-CoA: diphosphodolichol dehydrogenase: isomerase: ARO8 CDP adenylo-succinate transferase: XPT1 FCY1 IV: ADH4 acetoin synthase: PDC5 6-phosphogluconolactonase:F6P [+ 2 isozymes] in 18S rRNA synthase: EEB1 diphosphatase: HIS4 TPD3 PPH22 DSF1 8-en-3-one carrier-protein] diphosphate 4α-formyl-4β-methyl- mevalonate a long-chain a (3R)-3- phosphodiesterase: GDE1 N-acetylglucosaminyldiphosphodolichol pyruvate 3-deoxy-7- hydroxyphenyl) dUTP CDP reductase: acetaldehyde hydralase: FUM1 STR3 8-oxo-dGTP PGM1 1,3,4,5,6- diphosphate directed RNA- cis-prenyltransferase: α pyrophosphate lysophosphatidate MAE1 PMI40 phosphoheptulonate pyruvate CDP RNR2 alcohol acetoin synthase: PDC1 SOL3 fumarate cis-aconitate Man GlcNAc - succinate a peptide with ergosterol pentakisphosphate [+ 28 isozymes]keto-D-fructose polymerase] dehydratase: 5 -cholesta-8,24-dien- oleate fatty acid hydroxyoctadecanoyl- N-acetylglucosaminyltransferase: carboxylase: pyrophosphatase: [(R)-acetoin phosphofructokinase: putative 8-oxo-dGTP phosphoglucomutase: 9 2 met an mRNA fragment a proteinogenic phosphatase: NUS1 SRT1 β acyl-CoA acyltransferase: ethanolamine β adenylosuccinate dehydrogenase: ADH5 aconitate a dimethylarsenite- a tetrahydrofolate [protein] (isomer a 2-hydroxy an N-terminal 2+ HTD2 3 -ol,NAD(P)H:oxygen decarboxylase: MVD1 biosynthesis [acp domain within glycerol ALG13 ALG14 a dolichyl - PYC2 synthase: ARO4 reductase: DUT1 RNR4 RNR1 XMP forming]- PFK1 PFK2 cystathionine methylarsonous diphosphatase: PGM2 amino acid LPP1 Ca YNL257C cis-prenyltransferase: synthase: TGL4 D-mannosyl RNR2 lyase: ADE13 ethanol aldolase: hydratase: ACO2 [arsenite acid 8A B ) carboxylate L-proline YDL128W + a (2E)-hex-2-enoyl- oxidoreductase a fatty acid synthase] biosynthesis N-acetyl-β-D-glucosaminyl- phosphoribosylglycinamide ribonucleoside- diacetyl acetoin β beta-lyase: 1,2,3,4 1,4 a phosphatidate K NUS1 RER2 FAA3 oleoyl- phosphate phosphomannomutase: RNR4 RNR1 [+ 3 isozymes] dehydrogenase: ADH3 6-phosphogluconate -D-fructose 1,6- FBA1 aconitate methyltransferase] PCD1 [acp domain within (hydroxylating): ERG25 stearoyl-CoA CoA:lysophosphatidate (3R)-3- phospholipid biosynthesis (1->4)-N-acetyl-α-D- oxaloacetate formyltransferase: ADE8 diphosphate reductase: bisphosphate hydratase: ACO1 YHR112C 8-oxo-GMP a fatty acid synthase] stearoyl-CoA a long-chain[+ 2 isozymes] hydroxyacyl- DHAP II (Kennedy pathway) dolichyl-phosphate- SEC53 ribonucleoside- reductase: ethanol dehydrogenase, 8-oxo-dGMP acyltransferase: TGL5 glucosaminyl-diphosphodolichol 3-dehydroquinate BDH1 glyoxylate cycle triosephosphate cysteine-S + + IPP isomerase: IDI1 9-desaturase: fatty acyl-CoA [acyl-carrier- glycerol 3- mannose--protein FGAR diphosphate bifunctional thymidylate RNR1 RNR3 dehydrogenase: ADH2 Respiration decarboxylating: succinate all-trans- a (3R)-3- a trans-2- Na Na YJL132W oleoyl- chitobiosyldiphosphodolichol mannosyltransferase: phosphoenolpyruvate glycogen biosynthesis synthase: ARO1 aldolase: isomerase: TPI1 isocitrate -conjugate D-glucopyranose a 2-lysophosphatidylethanolamine ethanol a uridine in rRNA a reduced c- + YDR456W + 4α-carboxy-4β-methyl- OLE1 protein] phosphate β-mannosyltransferase: ALG1 carboxylkinase: PCK1 reductase: uridylate/adenylate synthase: CDC21 RNR2 RNR4 ethanol (R)-acetoin GND1 DHAP β-lyase: 2-oxoglutarate 4-hydroxybenzoateoctaprenyl thiosulfate O-acetyl-L-serine hν a carboxylic ester a D-amino acid hydroxyhexadecanoyl- AMP L-kynurenine enoyl-[acyl- K K oleoyl-CoA CoA:lysophosphatidate dehydratase: phosphatidylcholine biosynthesis I bifunctional choline kinase/ PMT2 PMT1 phosphoribosylformylglycinamidine RNR1 RNR3 kinase: URA6 adenine and adenosine salvage IV dehydrogenase: ADH1 acetyl-CoA FBA1 dehydrogenase: Carboxylate Degradation 6-phosphate serine/threonine medium-chain fatty type cytochrome NADP+ 5α-cholesta-8,24- dehydrogenase: UDP-α-D-glucose PSA1: synthetase: ADE6 2-ketoglutarate dehydrogenase complex succinyl-CoA IRC7 diphosphate diadenosine and diadenosine and [acp](3R)-3- Protein rRNA kynurenine-- carrier protein]enoyl-[acyl- L-serine/L- a hexanoyl-[acp domain β acyltransferase: SLC1 HTD2 GPD1 ethanolamine kinase: CKI1 [+ 4 isozymes] phosphoenol PSA1 4-coumarate RNR2 RNR4 AMP kinase: ADK1 glyceraldehyde- IDH1 IDH2 protein kinase: acid ethyl ester D-amino-acid N- pseudouridine cytochrome cystathionine phosphatase: dien-3 -ol:NAD(P) acyl-CoA pyruvate glycogenin ethanol ligase: LSC1 LSC2 oxalate lysophospholipase: PLB3 putative nitronate DNA-3- diphosphoinositol diphosphoinositol acetyltransferase: hydroxyacyl- Kinase of c peroxidase: oxoglutarate carrier- threonine + within a fatty acid synthase] + 3-oxidoreductase lysophosphatidic [+ 2 isozymes] ethanolamine kinase: EKI1 GDP-α-D- 3-dehydroquinate thymidylate dCDP triosephosphate 3-phosphate pyruvate fermentation L-malate [histone 4-hydroxybenzoate cysteine argininosuccinate PHO80 PHO85 synthase: EHT1 carboxylic ester PDH: PKP1 synthase: protein] beta-synthase: PHO8 K KHA1 YOL159C dimethylallyltransferase: thioesterase: acid sn-glycerol GDP-Man:Man GlcNAc phophopyruvate glucosyltransferase: dehydratase: FGAM ADP kinase: CDC8 kinase: YNK1 malate isomerase: TPI1 dehydrogenase: degradation VI pyruvate decarboxylation to acetyl CoA lysophospholipase: PLB1 monooxygenase: synthase: methyladenine deoxyribodipyrimidine polyphosphate polyphosphate hydrolase: CLD1 HPA3 [acyl-carrier- nucleoside- CCP1 transaminase: CYS4 ammonia- YIL118W polyprenol (decarboxylating) bifunctional choline kinase/ α 1 2 GLG2 mannose adenine D-ribulose-5- ribose-5- DHAP to acetate VIII degradation II H3]-lysine-4 YJR149W octaprenyltransferase: photo-lyase: PHR1 phosphohydrolase: lyase: ARG4 phosphohydrolase: [+ 127 isozymes] medium-chain fatty protein] [+ 4 isozymes] phosphate NOP10 CBF5 BNA3 reductase: [+ 5 isozymes] lyase: CHA1 ERG20 TES1 acyltransferase: 3-phosphate ethanolamine kinase: EKI1 -PP-dolichol -1,3- hydratase: ERR3 ARO1 synthase: MLS1 Phosphate 3- phosphate TDH1 2-oxoglutarate Secondary Metabolite Degradation lysophospholipase: PLB2 demethylase: MCY1 glycosylase: acid ethyl ester [+ 2 isozymes] a [pyruvate GAR1 NHP2 an oxidized c- + reductase: : ERG26 phosphoethanolamine mannosyltransferase: α-D-mannosyl- glycogenin phosphoribosylformylglycinamidine dCDP ADP reductase: dCTP isocitrate alpha- oxalate a [pyruvate COQ2 MAG1 DDP1 DDP1 dehydratase: dehydrogenase kinase: ETR1 NAD pyruvate DFG10 ICT1 choline kinase: CKI1 [protein] α-1,2 [+ 4 isozymes] dolichyl phosphate D- 3-dehydroshikimate lyase: ICL1 malate ketoglutarate epimerase: ketol- glyceraldehyde- [+ 2 isozymes] dehydrogenase (S)-malate lysophospholipase: NTE1 JHD2 a myo-inositol- synthase: EEB1 type cytochrome a 2,3,4-saturated geranyl diphosphate cyclo-ligase: ADE5,7 kinase: RNR2 RNR4 RNR1 dTDP 6 Ins(1,2,3,4,5,6)P HTD2 E1 α subunit]-L- ADK2 phosphocholine cytidyltransferase: ECT1 ALG2 2-phospho- glucosyltransferase: mannose biosynthesis 4-hydroxybenzaldehyde synthase: DAL7 RPE1 oxalate--CoA pyruvate carboxy- malate sorbitol degradation [unspecified 6 val YDR046C val a 3-oxooctanoyl-[acp domain oleoyl-CoA: mannosyltransferase: GLG1 YNK1 kinase: YNK1 adenine adenine dihydrolipoamide dehydrogenase: isomerase: 3-phosphate E2 protein] N pyruvate xylitol degradation 3-oxopropanoatenitrite degradation 4-hydroxy-3- acetate polyphosphate an alcohol a carboxylate a (2E)-hexadec- serine phosphate fatty acyl-[acp] within a fatty acid synthase] ω lysophosphatidate a stearoyl-[acp CDP-ethanolamine D-glycerate shikimate aminohydrolase: AAH1 KGD1 RKI1 13-DPG ligase: PCS60 lyase: PDC6 -lipoyl-L-lysine dehydrogenase: a [histone S-sulfo-L-cysteine an apurinic site 2-enoyl-[acp] YLR443W 3-keto-4- ,E,E-farnesyl glycerol 1- choline-phosphate KTR1 F6P 4-hydroxybenzaldehyde phosphoribosyltransferase: dehydrogenase: D-xylulose dehydrogenase: 2-ketoglutarate dehydrogenase: a carboxylate sn-glycero-3-phosphoethanolamine succinate products] octaprenylbenzoate diphosphate acyltransferase: domain within a ethanolaminephosphotransferase: α-D-mannosyl- dehydrogenase: deoxycytidylate dADP APT1 LPD1 NADH repair TDH1 pyruvate PDB1 PDA1 MAE1 D-sorbitol H3]-L-lysine-4 within DNA GDP dolichol methylzymosterol LOA1 fatty acid synthase] phosphate cytidylyltransferase: PCT1 mannose-6-phosphate ARO1 dehydrogenase: HFD1 phosphoribosylaminoimidazole deaminase: DCD1 5-phosphate 3-phosphoglycerate dehydrogenase decarboxylase: PDC5dihydrolipoamide pyruvate Unknown: SOR2 xylitol Fe 2+ YLR034C kinase: reductase: ERG27 synthase: ERG20 EPT1 GDP-Man:Man GlcNAc [protein] α-1,2 adenine D-threo-isocitrate (S)-malate [+ 2 isozymes] complex: LPD1 oxalyl-CoA dehydrogenase: Xylitol α 2 2 glycogenin isomerase: PMI40 carboxylase: ADE2 kinase: PGK1 pyruvate carboxy- sorbitol SEC59 glycerol-1- -PP-dolichol -1,6- mannosyltransferase: shikimate phosphoribosyltransferase: KGD1 KGD2 YMR31 decarboxylase: LPD1 α 20b α α 3-phosphoinositide biosynthesis CDP-choline glucosyltransferase: D-mannopyranose 6-phosphate NADH dehydrogenase: dehydrogenase: + a protein containing an an unbranched - 3-(hydroxymethyl) a uracil a peptide with 4 -methyl- (indol-3-yl) 4 -methyl- YJR150C a (3R)-3-hydroxyoctanoyl- sphingolipid biosynthesis (yeast) phosphatase: mannosyltransferase: KTR3 dADP kinase: YNK1 APT2 aconitate malate transketolase: C1 Compound Utilization and Assimilation PXP1 lyase: PDC1 a [pyruvate XYL2 dethiobiotin a chitodextrin lauroyl-CoA H a [release factor]- ethanol cholesterol L(or D)-O- 3-hydroxy- α YHR214W [acp domain within a dolichyl GPP1 GLG2 thymidylate hydratase: ACO2 dehydrogenase: acetaldehyde a [pyruvate dehydrogenase SOR1 aryl-carrier protein hν (L-serine/L-threonine) (1,6)-D-mannan L-glutamine -5-methylphenol in tRNA an N-terminal a palmitoyl-[acp] cholesta- acetamide 5 -cholest- diacylglycerol ALG2 α shikimate hypoxanthine TKL1 9 phosphoserine L-kynurenine a fatty acid synthase] phosphate 4-α-methylzymosterol,NAD(P) -D-mannosyl- 3-phosphoglycerate glycogenin phosphomannomutase: synthase: MAE1 formyl-CoA dehydrogenase 6 acetate keto-D-fructose D-xylulose -L-prolinemitogen- motif putative mannan peptide chain tRNA (guanine -N1) putative medium-chain fatty tRNA- sterol O- L-alanine enoyl-[acyl- 8,14-dienol amidase:7-en-3-one YKR052C glycerol-1- cholinephosphotransferase: α-D-Man-(1->3)-[α-D-Man-(1->6)]- α kinase: ARO1 phosphoribosyltransferase: aconitate transketolase: 3-phosphoglycerate enzyme-6 E2 protein] N -S- D-gluconate 20b kynurenine-- delta(14) 3-keto- (3R)-3- H:oxygen oxidoreductase palmitoyl-CoA α β [protein] -1,2 kinase: PGK1 glucosyltransferase: SEC53 CDC21 dATP AMP formate assimilation into 5,10- acetaldehyde:NADP+ E2 protein] N - conversion activated protein endo-1,6-alpha- release factor -methyltransferase: aryl-alcohol acid ethyl ester dihydrouridine acyltransferase: phosphoserine putative NTA1 phosphatase: CPT1 -D-Man-(1->4)- -D-GlcNAc-(1->4) phosphoribosylaminoimidazolesuccinocarboxamide HPT1 hydratase: ACO1 [+ 2 isozymes] TKL2 kinase: PGK1 formaldehyde oxidation formaldehyde oxidation dihydrolipoyllysineacetyldihydrolipoyl- to acetyl-CoA degradation xylulokinase: biotin endochitinase: 3-oxomyristoyl- alpha mannosidase: 5 YSA1: phosphatase: metalloprotease: oxoglutarate carrier- -sterol steroid hydroxyacyl-[acyl- (hydroxylating): ERG25 acyl-CoA sterol:steryl ester interconversion α mannosyltransferase: GLG1 dTMP dTMP de novo biosynthesis (mitochondrial) methylenetetrahydrofolate oxidoreductase: ALD6 dihydrolipoyl-L-lysineacetyltransferase:L-lysine CTS1 kinase: HOG1 N -glutamine TRM10 dehydrogenase: synthase: EHT1 synthase: DUS4 ARE2 arginine/alanine transaminase: protein] reductase: amidase: reductase: serine C- phosphatidylinositol GPP2 diacylglycerol - -D-GlcNAc-diphosphodolichol p-aminobenzoate synthase: ADE1 xanthine phosphoribosyl II (glutathione-dependent) II (glutathione-dependent) XKS1 synthase: acyl carrier deoxyribodipyrimidine CoA synthase: tRNase mannosidase: DFG5 YSA1 SER2 ATP23 2+ carrier-protein] 4α-hydroxymethyl-5α- stearoyl-CoA thioesterase: DP-Man:Man GlcNAc α KRE2 (1,4-α-D-glucosyl) cis-aconitate oxaloacetate (R)-NADHX D-sedoheptulose 3-phospho-D-glycerate 2-phospho- aldehyde LAT1 acetate D-gluconate [+ 4 isozymes] methyltransferase: AAD15 medium-chain fatty sterol O- aminopeptidase: BNA3 reductase: ERG24 AMD2 ERG27 YJL133W Fe octanoyl-[acyl-carrier palmitoyltransferase: TES1 synthase: PIS1 cholinephosphotransferase: 3 2 an -D-Man- biosynthesis thymidylate transferase: XPT1 dihydrolipoyl BIO2 protein: ACP1 ChiTinaSe: photo-lyase: PHR1 ELO1 Z: TRZ1 AMS1 a protein containing a dehydratase: β glycerol α -glucosyl NADHX 7-phosphate D-glycerate dehydrogenase: ALD4 acetyl CoA Defective Cell MTQ2 TRM1125 [+ 4 isozymes] acid ethyl ester acyltransferase: AAP1 (indol-3-yl)acetate cholesta-8,24-dien-3 -ol lanosteryl oleate -PP-dolichol -1,2- α n translation initiation 3-phosphoshikimate 1- transsuccinylase: formaldehyde gluconokinase:β-D-fructofuranose CTS2 phosphorylated (L-serine/L- xanthurenate ETR1 lophenol HTD2 protein] biosynthesis ORM1 SAC1 ORM2 EPT1 (1->2)- -D- glyceraldehyde- glucogenin SAICAR UMP biosynthesis II kinase: CDC8 Other aconitate epimerase: phosphoglycerate phophopyruvate formate--tetrahydrofolate synthetase: Wall: DCW1 a [release factor]-N 3-hydroxy-5- synthase: EEB1 ARE1 a (2E)-hexadec- 4α-hydroxymethyl-5α- (mitochondria, yeast) stearate mannosyltransferase: Man-3-O-(Ser/ factor catalytic carboxyvinyltransferase: dihydrofolate KGD2 aldehyde YDR248C threonine)-L-proline motif methylbenzaldehyde a long-chain acyl- D-ribofuranose a (2E)-oct-2-enoyl- β TSC3 LCB1 LCB2 a phosphatidylcholine steryl ester hydrolase: TGL1 steryl ester hydrolase: TGL1 ALG11 3-phosphate dTDP reductase: superpathway of pyrimidine hydratase: ACO1 (S)-NADHX NNR1 transaldolase: mutase (2,3- hydratase: ERR3 ligase: MIS1 dehydrogenase ACS2 fructokinase: HXK2 a quinoxaline-2- D-mannopyranose -methyl-L-glutamine AMP 5-phosphate 2-enoyl-[acp] [acp domain within cholesta-8,24-dien-3 - α Thr)-[protein] subunit epsilon: GCD6 ARO1 aminodeoxychorismate 5'-phosphoribosyl-4-(N- thymidylate diphosphoglycerate- formate--tetrahydrofolate formate 5'-deoxyadenosine met AMP a thymidine in DNA 6-phosphate cholesterol ester lys YBR147W ol,NAD(P)H:oxygen an acetoacetyl-[acp] steryl ester hydrolase: YEH1 steryl ester hydrolase: YEH1 [+ 5 isozymes] GDP- -D-mannose α-D-mannosyl-(1,2) dehydrogenase: 5-enolpyruvoyl- gln DFR1 nucleobases salvage malate/L-aspartate aconitate NQM1 [+ 4 isozymes] S-(hydroxymethyl) dehydrogenases: (NADP+): ALD5 acetyl CoA fructokinase: HXK1 carboxyl-[aryl- ala a fatty acid synthase] 3-dehydroicosasphinganine phosphatidylinositol phosphatidylinositol lanosterol O- ergosterol O- synthase: ABZ1 succinocarboxamide) dTDP synthase: glycerol-3-phosphate shuttle citrate ATP- dependent): GPM1 10ligase: ADE3 oxidoreductase 3-oxoacyl- steryl ester hydrolase: YEH2 steryl ester hydrolase: YEH2α-D-Man-(1->2)-α-D-Man-(1->2)- -α-D-mannosyl- TDH1 4-amino-4- -5-aminoimidazole kinase: uracil shuttle pathway hydratase: ACO2 transaldolase: phosphoenol an N - glutathione FDH1 synthetase: carrier protein] 4-kinase: STT4 3-kinase: VPS30 oleoyltransferase: ARE2 oleoyltransferase: ARE2 α α dolichyl-phosphate α shikimate 3-phosphate CDC21 synthase: CIT2 dependent TAL1 acetate (hydroxylating): ERG25 [acyl-carrier- 3-dehydrosphinganine [+ 2 isozymes] VPS34 ATG14 bifunctional triglyceride lipase/ bifunctional triglyceride lipase/-D-Man-(1->3)-[ -D-Man-(1->6)]- mannose [protein] -1,2 [+ 2 isozymes] dolichyl-phosphate deoxychorismate lyase: ADE13 YNK1 uracil pyruvate formyltetrahydrofolate S-hydroxymethyl- S-hydroxymethyl- ACS1 protein] reductase: TSC10 3-dehydrosphinganine slanoterol O- ergosterol O- β-D-Man-(1->4)-β-D-GlcNAc-(1->4) mannosyltransferase: D-glyceraldehyde UDP-glucose-starch chorismate carbamoyl DHAP acetyl-CoA NADH-hydrate glutathione glutathione CO YNL268W lys reductase: TSC10 VPS15 ATG38 oleoyltransferase: ARE1 lysophosphatidylethanolamine oleoyltransferase: ARE1 lysophosphatidylethanolamine synthase: DPM1 mannose synthase: aminodeoxychorismate phosphoribosyltransferase: guanine and asp dehydratase: D-erythrose pyruvate trifunctional formate- 2 a medium-chain 2,3,4- a dimer of adjacent (5Z,8Z,11Z,14Z,17Z) a [lipoyl-carriera ribonucleoside 5-(hydroxymethyl) a [protein]-L- a guanosine 18 reductase: acyltransferase: TGL3 acyltransferase: TGL3 -α-D-GlcNAc-diphosphodolichol KRE2 3-phosphate glucosyltransferase: synthase: DPM1 AICAR phosphate a 5,10- a tetrahydrofolate FUR1 aspartate F6P phophopyruvate dehydrogenase: dehydrogenase: hydrogen cyanide a very-long-chain fatty acid (R)-lipoate NADH nitric oxide sphinganine phosphatidylinositol an α-D-Man- ARO2 lyase: ABZ2 methylenetetrahydrofolate guanosine salvage NNR2 4-phosphate kinase: tetrahydrofolate ligase/ saturated fatty acid pyrimidine -icosapentaenoyl-CoA L-homocysteine protein]-L-lysine 2',3'-cyclic -2-methylphenol a ferrihemoglobin proline (ω = 180) in tRNA α α OAR1 [+ 2 isozymes] [+ 2 isozymes] a dolichyl β-D-mannosyl phosphate GSY2 synthase: aminotransferase: AAT2 hydratase: ERR3 PYK2 methenyltetrahydrofolate SFA1 SFA1 nucleosides in DNA phosphate aryl-alcohol dipeptidyl Resistant to Yeast 4 -formyl-5 - 3-kinase: VPS34 (1->2)-α-D- aldolase: phosphoribosylaminoimidazolecarboxamideURA2 transketolase: [+ 4 isozymes] S-adenosylmethionine- mitochondrial putative NADH- tRNA protein-tyrosine- tRna ribose enoyl-[acyl- 3'(2')5'- cholesta-8,24-dien-3β- sphinganine C4- VPS15 VPS30 VPS38 Man-(1->2)-α- UDP-glucose-starch 4-aminobenzoate formyltransferase: ADE16 bifunctional thymidylate/ aspartate glycerol-3- glycerol 3- NADH pyruvate cyclohydrolase/ S-formylglutathione homocysteine S- 2',3'-cyclic-nucleotide tRNA dehydrogenase: aryl-alcohol cytochrome b methyltransferase: aminopeptidase: Rapamycin TEnsin-like methylase: bisphosphate HemogloBin- guanine YJL059W arg ergosterol FBA1 superpathway of phosphate TKL2 S-formylglutathione long-chain fatty acid- very-long-chain acyl-CoA putative 3'-phosphodiesterase: 5 NAD(+) Phosphatase: phosphatase: carrier- ol,NAD(P)H:oxygen hydroxylase: D-Man-3-O-(Ser/ glucosyltransferase: phosphoribosylaminoimidazolecarboxamide uridylate kinase: CDC8 guanosine aminotransferase: AAT1phosphate phosphoenolpyruvate kinase: methylenetetrahydrofolate thiosulfate methyltransferase: SAM4 aldolase: pseudouridine 27/28 AAD15 dehydrogenase: reductase: CBR1 PPM2 DAP2 Deletion: PHO8 TRM3 protein] nucleotidase: like protein: deaminase: (3R)-3- SUR2 phosphatidylinositol a 1-phosphatidyl- GSY1 carbamoyl guanosine nucleotides oxaloacetate dehydrogenase: transketolase: CDC19 dehydrogenase: ADE3 CoA ligase: FAA2 sulfurtransferase: fatty acid--CoA deoxyribodipyrimidine thioesterase: lipoate--protein CPD1 FBA1 [+ 4 isozymes] AAD15 a [protein]-L- RRD2 diphosphatase: TEP1 YHB1 YMR305C oxidoreductase Thr)-[protein] β-D-fructose 1,6- formyltransferase: ADE17 asp UMP kinase: URA6 guanosine dehydrogenase: S-formylglutathione S-formylglutathione ligase: FAT1 photo-lyase: PHR1 TES1 S-Methylmethionine ligase: AIM22 synthase: PUS2 [+ 3 isozymes] 5 dipeptidyl NPY1 reductase: MET22 GUD1 (hydroxylating): ERG25 hydroxyacyl- 4-phosphate 1D-myo-inositol α-D-Man-(1->2)-α- phosphate de novo biosynthesis I serine GPD1 TKL1 pyruvate [+ 3 isozymes] RDL1 a ribonucleoside [+ 4 isozymes] glutamate-O aminopeptidase: [+ 10 isozymes] YBR132C very long chain fatty [acyl-carrier- phytoeicosasphingosine a 1-phosphatidyl- kinase: MSS4 a dolichyl β-D-mannosyl phosphate D-Man-(1->2)-α-D- bisphosphate UDP phosphorylase: PNP1 malate GUT2 D-glyceraldehyde methenyltetrahydrofolate hydrolase: YJL068C hydrolase: YJL068C Homocysteine 3-hydroxybenzaldehyde [+ 14 isozymes] ETR1 YEL063C acid biosynthesis 3-phosphate PRPP biosynthesis FAICAR hydroxymethyltransferase: dehydrogenase: MAE1 [+ 2 isozymes] kinase: PYK2 cyclohydrolase: MIS1 2'-phosphate -methyl-ester STE13 a [protein]-L- 4α-carboxy-5α-cholesta-8,24-dien-3β-ol protein] 1D-myo-inositol Man-[protein] α-1,3- fructose-1,6- aspartate SHM2 guanine 3-phosphate formate Nucleoside and Nucleotide Degradation methylTransferase: MHT1a [lipoyl-carrier protein]- D-glyceraldehyde proline (ω = 0) a 1-phosphatidyl- phosphatidylinositol 1,4-glucan-6- UDP kinase: YNK1 [+ 3 isozymes] pyruvate a 5,10- a medium-chain 2,3,4- two adjacent pyrimidine 6 DHAP dehydratase: 3,4-bisphosphate 3,5-bisphosphate monoacylglycerol metabolism dolichyl-P-Man:Man mannosyltransferase: bisphosphatase: (1,4-glucano) D-ribose 5- inosine carbamoyltransferase: kinase: AMP saturated fatty acyl CoAdiphosphate thiocyanate met N -[(R)-lipoyl]-L-lysine 4α-carboxy-5α-cholesta- HTD2 1D-myo-inositol phoshatidylinositol-3- 5 glycine sn-glycerol methenyltetrahydrofolate nucleosides in DNA YKL164C 5-phosphatase: phosphate 5-kinase: GlcNAc -PP- MNN1 FBP1 -transferase: phosphate monophosphate URA2 IMP hydroxymethyltransferase: UTP guanine CDC19 formate purine ribonucleosides degradation 3-oxo- 8,24-dien-3β-ol:NAD(P) 4,5-bisphosphate 1-oleoyl- dolichol α-1,3-2 α α phosphoribosylpyrophosphate cyclohydrolase: dehydrogenase: phosphoribosyltransferase: 3-phosphate methylenetetrahydrofolate dehydrogenases: formate UTP and CTP dephosphorylation I UTP and CTP dephosphorylation II YNL270C a (3R)-3-hydroxydecanoyl- arachidoyl-CoA + 3-oxidoreductase a very-long-chain ATG18 VAC7 ATG18 VAC7 sn-glycerol -D-Man-(1->2)- - GLC3 synthetase: PRS5 PRS2 SHM1 CTP synthase: URA8 dehydrogenase FDH1 oxidation to CO a phytosphingosine FIG4 VAC14 FAB1 mannosyltransferase: α ADE16 IMD4 HPT1 + 2 a dimer of adjacent 3,5-bisdiphosphoinositol- 2791 α [acp domain within synthase: ELO2 (decarboxylating) fatty acyl-CoA FIG4 VAC14 FAB1 D-Man-(1->2)- -D- ribose-phosphate N-carbamoyl- CTP synthase: URA7 (NADP ): ADE3 UTP an [eIF5A- an 1-acyl-2- a ribonucleoside adenosine a [histone a uridine a [mitogen- an aromatic 4 -carboxy- an N-terminal [+ 2 isozymes] ALG3 Man-[protein] α-1,3- glucose-6- UDP-α-D-glucose inosine L-aspartate [+ 2 isozymes] xanthine phosphoribosyl adenosine coenzyme A thymidine and 2'- ν 1D-myo-inositol 2,3,4,6- 2',3'-cyclic activated protein 4β-methyl- a fatty acid synthase] 3-oxo- : ERG26 enoyl-[acyl- acyl- 1-oleoylglycerol pyrophosphokinase: biosynthesis I methylenetetrahydrofolate formate h precursor]-lysine arachidonoyl-sn-glycerol triphosphate H3]-L-lysine-4 in 21S rRNA primary alcohol glycyl-[protein] lys lys YLR040C (3R)-3- arachidoyl-CoA carrier-protein] ceramide CoA:monoacylglycerol mannosyltransferase: phosphate monophosphate transferase: XPT1 formate tRNA deoxycytidine in DNA tetrakisphosphatediadenosine andmonophosphate histone H3 lysine-4 N (2R,3S)-3- aryl-alcohol 21S rRNA 25S rRNA aryl-alcohol kinase]-L-threonine aryl-alcohol 5α-cholesta- sphinganine amidase: tyrosine N-myristoyl leukotriene catalase: YOL092W YCL027W lipase: YJU3 MNT3 isomerase: PRS2 PRS1 cyclohydrolase: dihydrooratase: dehydrogenase nucleoside- CTP synthase: URA8 UTP phosphatase: CTP synthase: URA8 2',3'-cyclic-nucleotide dehydrogenase: 2843 3 dehydrogenase: Mitogen- dehydrogenase: β acylglycerone- kinase: YSR3 NTA1 protein CTT1 arg arg hydroxyacyl-[acyl- synthase: ELO3 zymosterone reductase, synthase: acyltransferase:2-oleoylglycerol DGA1 1-oleoyl-sn 1-oleoylglycerol an α-D-Man- D-glucopyranose (NADP + ): MIS1 dehydrogenases: adenosine triphosphatase: FAP7 CTP synthase: URA7 YND1 threonylcarbamoyladenosine diphosphoinositol -trimethyltransferase: isopropylmalate 4- (uridine2791-2'-O) (uracil -N )- activated 8-en-3sterol-4-alpha--ol transferase: A4 carrier-protein] α PGI1 ribose-phosphate 6-phosphate ADE17 URA4 GMP deaminase: CTP synthase: URA7 deoxyhypusine diacylglycerol DNA 3'-phosphodiesterase: SWD2 SWD3 methyltransferase: AAD10 methyltransferase: methyltransferase: AAD15 AAD15 carboxylate 3- phosphate sphinganine amidase: kinase: hydrolase: catalase: 3-oxoicosanoyl-CoA mitochondrial: LIP1 LAG1 phosphatidylcholine biosynthesis V lipase: YJU3 -glycerol 3- lipase: MGL2 (1->3)- -D- pyrophosphokinase: phosphoglucomutase: a 5,10- FDH1 UTP phosphatase: YND1 Phosphopantetheine:Protein dehydratase: TCD1 deoxyribodipyrimidine polyphosphate CPD1 Kinase reductase: AYR1 NMT1 dehydratase: 5α-cholesta-8,24-dien-3- ETR1 α D-glucopyranose GMP AAH1 synthase: DYS1 lipase: TGL3 primase: BRE2 SWD1 SDC1 TMT1 [+ 4 isozymes] MRM2 BMT63 [+ 4 isozymes] [+ 4 isozymes] dehydrogenase kinase: LCB3 AMD2 MPS1 an N-terminal LAP2 CTA1 ceramide phosphate Man-(1->2)- - 1,3-β-D-glucan PRS3 PRS1 PGM1 (S)-dihydroorotate methylenetetrahydrofolate CTP UMP CTP Transferase: PPT2 tRNA photo-lyase: PHR1 phosphohydrolase: an N - Kinase: MKK2 an aromatic HTD2 3-oxo- one reductase: ERG27 (mannosyl) -(N- D-Man-(1->2)-α- 6-phosphate biosynthesis synthase: PRI2 PRI1 DDP1 SHG1 SET16 SPP1 methyluracil 2843 p-cumic aldehyde (decarboxylating) a sphingoid 4-guanidinobutanoate [+ 3 isozymes]N-myristoyl- leukotriene B formaldehyde mitochondrial synthase: 6 ribose-phosphate phosphoglucomutase: UDP threonylcarbamoyladenosine 1D-myo-inositol 3- a [histone H3] N [+ 3 isozymes] aldehyde α 4 YFR024C-A arachidoyl-CoA acetylglucosaminyl) - D-Man-3-O-(Ser/ GUA1 inosine nucleoside- CTP diphosphatase: an [eIF5A- 6 6 in 25S rRNA 4 -methyl-: ERG26 1-phosphate glycyl-[protein] proton- reductase: IFA38 zymosterol LAC1 LIP1 2 PGM2 dihydroorotate dehydratase: TCD2 diphosphate 1,2,4,5,6- ,N ,N -trimethyl- α + + phosphatidylethanolamine diphosphodolichol:dolichyl Thr)-[protein]α pyrophosphokinase: UTP phosphatase: YND1 triphosphatase: FAP7 YND1 3',5'-ADP adjacent thymidine-2'- precursor]- a fatty acid ssDNA/pppN(pN) L-lysine-4 5 -cholesta- H transporting H fatty acid biosynthesis glycerol -D-Man-(1->3)- β PRS4 PRS1 dehydrogenase: GMP CTP diphosphatase: YND1 pentakisphosphate ATP synthase initiation (mitochondria) N-methyltransferase: CHO2 β-D-mannosyl phosphate α-D-Man-(1->2)-α- 1,3- -D-glucan IMP URA1 CMP deoxycytidine in DNA deoxyhypusine hybrid 8-en-3-one SAM:C-24 sterol mannosyl transferase: ALG9 synthase: ribose phosphate n -1 complex YOR383C methyltransferase: ERG6 α α D-Man-(1->2)-α-D- UDP-glucose dehydrogenase: inosine guanosine CDP 3-hydroxy- -D-Man-(1->2)- -D-Man-(1->2)- α RHO1 FKS3 diphosphokinase: pyrophosphorylase: IMD4 orotate GMP phosphorylase: phosphorylase: a 3-oxohexanoyl- ceramide very acetyl-CoA α-D-Man-(1->3)-[α-D-Man-(1->2)- Man-[protein] -1,3- IMP 5'-nucleotidase: ISN1 a dimer of adjacent 46 2634 a 1-phosphatidyl- vacuolar arachidoyl-CoA phosphatidyl-N- [+ 2 isozymes] PRS5 PRS4 UGP1 [+ 2 isozymes] kinase: PNP1 PNP1 CTP diphosphatase: YND1 an N-terminal L- guanosine N-methyl-N-[(2S) 3-methylbenzyl a guanine a uracil a [mitogen- an organic D-sedoheptulose a monocarboxylic fecosterol [acp] long chain fatty methylethanolamine α-D-Man-(1->3)-α-D-Man-(1->6)]- mannosyltransferase: β PRPP orotate UMP phosphatase: PHM8 S-methyl-5'-thioadenosine coenzyme A an apo-[aryl- 2'-deoxycytidine and RNA 2',3'-cyclic -1-phenylpropan- acetaldehyde activated protein 1-phosphate 1D-myo-inositol a DNA segment 31-norcycloartanone proton dehydratase: acetyl-CoA β β MNT2 chitin biosynthesis a 1,3- -D-glucan UTP glucose- GUK1 carrier protein] glutamyl-[protein] alcohol in tRNA in 25S rRNA hydroperoxide acid amide translocating PHS1 acid hydroxylase: carboxylase: ACC1 N-methyltransferase: -D-Man-(1->4)- -D-GlcNAc-(1->4) phosphoribosyltransferase: α-D-ribose- degradation II thymidine in DNA monophosphate 2-yl]hydroxylamine aryl-alcohol Transfer RNA 25S rRNA NADPH- kinase]-L-tyrosinemitogen- alkyl 3,4-bisphosphate recombinase: 3-keto- 1-oleoyl-sn amidase: 3-keto- catalase: C-8 sterol SCS7 OPI3 -α-D-GlcNAc-diphosphodolichol α-D-Man-(1->3)- 1-phosphate asp GDP 2',3'-cyclic-nucleotide leucine carboxy N,N-dimethylaniline dehydrogenase: (uracil 2634 -N 3 )- dependent alcohol hydroperoxide TEnsin-like steroid NTA1 steroid CTT1 ATPase YDR077W isomerase: ERG2 acetyl-coenzyme dolichyl-P-Man:Man uridylyltransferase: XMP URA5 1-phosphate IMP 5'-nucleotidase: ISN1 S-methyl-5'- carbonate invertase: methyltransferase: monooxygenase: methyltransferase: activated fructose- Phosphatase: DMC1 -glycerol 3- complex trans-arachido-2-enoyl-CoA a very-long-chain (2'R)- a phosphatidyl-N- 7 α-D-Man-(1->2)-α- α,α-trehalose arginyltransferase: FOLic acid ribonuclease 3'-phosphodiesterase: AAD10 TRM82 TRM8 methyltransferase: dehydrogenase: reductase: AHP1 reductase: amidase: reductase: catalase: a (3R)-3- A carboxylase, GlcNAc -PP- YHL012W orotate phosphoribomutase: CMP phosphatase: PHM8 thioadenosine Phosphopantetheine:Protein deoxyribodipyrimidine dehydratase: SUC2 CPD1 PPM1 FMO1 7 protein kinase bisphosphate TEP1 [+ 2 isozymes] phosphate 2'-hydroxy-phytoceramide α 2 D-Man-(1->2)-α-D- 5'-methylthioadenosine synthesis: FOL1 T2: RNY1 [+ 4 isozymes] an N - BMT53 ADH6 [+ 5 isozymes] a DNA segment ERG27 AMD2 ERG27 CTA1 met YGR055W met episterol mitochondrial: HFA1 dimethylethanolamine dolichol -1,6- adenylosuccinate phosphoribosyltransferase: ATE1 (Z)-methyl(oxido) 46 an N - kinase: STE7 phosphatase: β a 3-oxododecanoyl- trans-arachidon- hydroxyhexanoyl- Polyprenyl Biosynthesis α GMP GDP GDP superpathway of pyrimidine ribonucleosides salvage PRM15 phosphorylase: MEU1 Transferase: PPT2 photo-lyase: PHR1 NCE103 2634 aldolase: FBA1 a 3 - inositol phosphatidyl-N- mannosyltransferase: Man-[protein] -1,3- trehalase: UDP-α-D-glucose synthetase: ADE12 URA10 cytidine (1-phenylpropan- 3-methylbenzaldehyde methylguanine methyluracil ethanol [+ 3 isozymes]an alcohol in reverse 31-norcycloartanol PHM8 acetaldehyde [acp domain within 2-enoyl-CoA [acp] phosphorylceramide malonyl-CoA mannosyltransferase: synthase: kinase: reductase: D-ribose 5- in tRNA orientation hydroxysteroid reductase: TSC13 C-5 sterol (3R)-3- dimethylethanolamine N ALG12 NTH1 GUA1 YNK1 RNR2 an N-terminal an [RNA]-3'- a 5'-hydroxy- β-D-fructofuranosea glycoside 2-ylidene)azanium in 25S rRNA a fatty acid synthase] synthase: KEI1 AUR1 superpathway of an α-D-Man-MNT3 cytidine phosphate Arg glycolaldehyde YOL132W desaturase: ERG3 hydroxyacyl- acetyl-CoA malonyl CoA-acyl -methyltransferase: OPI3 alpha,alpha- Tetrapyrrole Biosynthesis orotidine 5'- RNR4 RNR1 3',5'-ADP a tRNA L-arginiyl-L- adjacent 2'-deoxycytidine- H O ribonucleoside- ribonucleotide- DHAP YHL036W arachidoyl-CoA geranylgeranyldiphosphate hexaprenyl (1->3)-α-D- Amino Acid Degradation glutamyl-[protein] thymidine in DNA 2 3'-phosphate 3'-[RNA] ergosta-5,7,24(28)-trien-3β-ol [acyl-carrier- carrier protein diphosphate α α trehalase: GMP phosphate cytidine cytidine kinase: URK1 a phosphatidylcholine biosynthesis I (via mevalonate) UDP- -D-glucose Man-(1->3)- - NTH2 adenylosuccinate GTP a (3R)-3-hydroxydodecanoyl- 3-oxo- protein] transacylase, biosynthesis D-Man-(1->2)-α- superpathway of heme b lyase: ADE13 orotidine-5'- deaminase: CDD1 dehydratase: mitochondrial: MCT1 UDP-glucose:dolichyl- heme a siroheme biosynthesis dGDP valine degradation Degradation/Utilization/Assimilation - Other 1 2922 2870 38/ YGR189C behenoyl-CoA C-22 sterol α trehalose biosynthesis II biosynthesis from glycine GMP CMP 7,8-dihydrofolate 1 N - 4-methylbenzyl a [lipoyl-carrier [acp domain within acetyl-CoA C- (mannosyl) -(N- D-Man-(1->2)- - α β biosynthesis phosphate L-phenylalanine isoleucine degradation II tryptophan degradation VIII (to tryptophol) asparagine a 1-phosphatidyl- an L-arginyl- NADPH a guanosine a cytosine 1-palmitoylglycerone S-(hydroxymethyl) a uridine 6 L-iditol a ferricytochrome a [protein]- a D-hexose SAM YNL003C SAM synthase: ELO2 desaturase: ERG5 HTD2 inositol 8 phosphate -D-glucopyranose -D-glucopyranose uridine L-methionine degradation III Arg N -acetylspermine 2,5-hexanedione phytenoyl-CoA a fatty acid synthase] acyltransferase: POT1 hexaprenyl acetylglucosaminyl) - D-Man-3-O-(Ser/ kinase: decarboxylase: degradation II (anaerobic) degradation 1D-myo-inositol [tRNA ] monoglutamate acetylspermidine in 27S pre-rRNA in 25S rRNA 3-phosphate alcohol glutathione 39 in tRNA protein]-N -[(R) Unknown: SOR2 b L-cysteine cys phosphorylceramide 2 glucosyltransferase: D-glucopyranose uroporphyrinogen-III dGDP CMP kinase: URA6 glutathione-mediated 27S pre-rRNA 25S rRNA aryl-alcohol S-hydroxymethyl- tRNA -dihydrolipoyl]- 5 sphinganine hexokinase: 2,5- 2-enoyl ferroxidase: (3R)-3- 3-oxo- a (2E)-hex- diphosphate diphosphodolichol:dolichyl Thr)-[protein] GUK1 URA3 val histone H3 lysine-36 N 2870 5 1-acyl protein N-terminal 38/ NADH- protein S- mannosyltransferase: acetyl-CoA ALG5 6-phosphate uroporphyrinogen-III bifunctional kinase: uridine ile trp detoxification I alkylnitronates GlycosylPhosphatidylInositol (guanosine2922-2'-O) (cytosine -C )- dehydrogenase: glutathione pseudouridine L-lysine sorbitol kinase: LCB3 YLR446W cystathionine hexadione thioester FET3 hydroxyacyl-[acyl- behenoyl-CoA 2-enoyl-[acp] cardiolipin biosynthesis acetyltransferase: ERG10 synthase: β-D-mannosyl phosphate 5-aminolevulinate heme o uridylate/ L-valine:2- phe asn Udp- dihydrofolate N1- -trimethyltransferase: dihydroxyacetone asparagine dihydrolipoamide cytochrome b acyltransferase: beta-synthase: carrier-protein] synthase: ELO3 CSH1 CSG2 mannosyl transferase: ALG9 C-methyltransferase: GDP YNK1 nucleosidase: URH1CDP L-isoleucine:2- L-tryptophan:2- degradation anchoring biosynthesis: GPI1 arginyltransferase: polyamine -methyltransferase: SET2 methyltransferase: phosphate AAD10 dehydrogenase: amidohydrolase: 39 synthase: dehydrogenase: reductase: sphinganine SHR5 ERF2 [+ 2 isozymes] reductase: reductase: ferroxidase: YGL008C YJL079C C-24 sterol enoyl-[acyl- acetoacetyl-[acp] phospholipid remodeling (phosphatidylcholine) COQ1 α-D-Man-(1->2)-α-D-Man-(1->2)- a dolichyl β-D-glucosyl phosphate synthase: HEM1 synthase: adenylate uridine kinase: DAS2uracil oxoglutarate L-phenylalanine:2- L-phenylalanine:2-oxo- L-tryptophan:phenylpyruvate asparaginase: glycosyltransferase: reductase: acetylspermidine 6 dehydrogenase: SOR1 5 CYS4 dehydratase: inositol ADP-glucose MET1 oxoglutarate oxoglutarate RX GPI2 SPT14 GPI15 GPI19 ERI1 ATE1 oxidase: FMS1 SPB1 a [histone H3] N NOP2 reductase: AYR1 [+ 4 isozymes] SFA1 DEG1 38/ CBR1 kinase: YSR3a [protein]- D-hexose 6- GRE2 ETR1 FET5 α α COX10 uridine kinase: URK1 aminotransferas: ARO9 ASP3-4 DFR1 oxidase: FMS1 a 2-O- 6 6 NTA1 LPD1 3+ YLR046C reductase: ERG4 carrier- synthase: CEM1 -D-Man-(1->3)-[ -D-Man-(1->2)- D-glucopyranose trehalose-6- kinase: URA6 dGTP phosphoribosyltransferase: aminotransferase: oxoglutarate 4-methylthiobutanoate aminotransferase: ARO8 ATG26 2922 ,N ,N -trimethyl- an N-terminal L- a pseudouridine a [lipoyl-carrier a phytosphingosine S-palmitoyl- (2S,5S)- HTD2 protein] phosphorylceramide 1,2-dipalmitoyl-sn- hydroxymethylglutaryl- α α ferroheme o FUR1 aminotransferase: BAT1 aminotransferase: ARO8 [+ 4 isozymes] methylguanosine S-formylglutathione 6 [+ 3 isozymes] phosphate lanthionine phytanoyl-CoA Fe CDP-diacylglycerol-- -D-Man-(1->3)-[ -D-Man-(1->2)- phosphate AMP BAT1 aminotransferase: glutathione putative nitronate aspartyl-[protein] 39 in tRNA protein]-N -[(R 1-phosphate L-cysteine hexanediol + a (2E)-dodec-2-enoyl- 3-oxo-behenoyl- ergosterol reductase: mannosyltransferase: glycero-3-phosphocholine CoA synthase: ERG13 α α phosphoglucomutase: delta-aminolevulinate precorrin-1 C- branched-chain amino asp transferase: GTT2 monooxygenase: an N-terminal in 27S pre-rRNA L-lysine-36 YPL036W H glycerol-3-phosphate 3- -D-Man-(1->6)]- -D-Man-(1->6)]- synthase heme a GDP kinase: branched-chain 3-phenyl-2-ARO8 L-phenylalanine:2-oxo- a sterol 3-β- + )-lipoyl]-L-lysine [acp domain within CoA reductase: ETR1 CSG2 SUR1 acyl-CoA:lyso- β β glucokinase: PGM1 dehydratase: HEM2 methyltransferase: acid transaminase: BAT2 3-(indol-3-yl)pyruvate L-arginiyl-L- NADP 3-acetamidopropanalspermidine 3-acetamidopropanalputrescine YLR110C a fatty acid synthase] (4R)-4-hydroxy-N-[(2R)-2-hydroxy- phosphatidylcholine phosphatidyltransferase: -D-Man-(1->4)- -D-GlcNAc-(1->4) GLK1 phosphoglucomutase: synthase: reductase: GDP ADK1 UMP CDP kinase: YNK1 amino acid oxopropanoate 4-methylthiobutanoate glutathione YJR149W D-glucoside IFA38 very-long-chain-acyl]-1-O-{[6-O-(α- -α-D-GlcNAc-diphosphodolichol α α MET1 RNR2 aminotransferase: ARO9 carboxy-lyase: ARO10 transferase: GTT1 nitrite aspartyl-[protein] acyltransferase: ALE1 PGS1 [+ 2 isozymes] PGM2 , -trehalose porphobilinogen COX15 kinase: bifunctional thymidylate/ transaminase: phenylpyruvate D-mannosyl)-1D-myo-inositol-1-O- a phosphatidylglycerophosphate 3-hydroxy-3methylglutary- 6-phosphate RNR4 RNR1 BAT2 2-keto-methylvalerate methionine-oxo-acid indole-3-pyruvate L-phenylalanine degradation III [+ 2 isozymes] lys YCL038C (3R)-3-hydroxybehenoyl-CoA precorrin-2 YNK1 uridylate kinase: CDC8 carboxy- 8 2278 20a yl]hydroxyphosphoryl}sphinganine lyso- phospholipase CoA reductase: HMG2 (mannosyl) -(N- decarboxylase: THI3 transaminase: AAT2 carboxy-lyase: PDC6 a dimer of non-adjacent α β N - a cytosine a [cytochrome an adenine a uracil 4-nitrophenyl mannosyl-inositol- phosphatidylcholineA2: TGL4 acetylglucosaminyl)9 trehalose-6- porphobilinogen ADP UMP kinase: URA6 lyase: ARO10 4-(methylsulfanyl)-2-oxobutanoate hν 2'-deoxycytidine and a phosphatidylcholine a sterol an -D-mannoside a 1,3- -D-glucan L-arabinitol sn-glycerol sphingosine avenastenone 3-hydroxy- phosphatidylglycerophosphatase: 3-hydroxy-3-methylglutaryl- phosphate deaminase: HEM3 heme a precorrin-2 reductase: (3S)-3-methyl-2- indole-3-pyruvate acetylspermidine in 25S rRNA c]-L-lysine in mRNA in tRNA 3-phosphate L-homoserine phosphate phosphoceramide acyltransferase: TAZ1 -diphosphodolichol dehydrogenase: branched-chain- phenylpyruvate carboxy-lyase: PDC5 phe thymidine in DNA nucleoside triphosphate 25S rRNA [cytochrome dihydroxyacetone 6 L-arabinose L-glutamate γ- sphinganine 3-keto- 3-keto- amidase: behenoyl-CoA GEP4 CoA reductase: HMG1 2 phosphatase: UDP oxopentanoate histone H3 lysine-79 N PPN1: PPN1 mRNA m A tRNA- glycerol-3- p-nitrophenyl YPL224C inositolphosphotransferase: glucosyltransferase: glucose-6- dolichyl glucosyl synthase: MET8 RNR2 pyrimidine 2-oxoacid carboxy- 2-oxo-4- L-phenylalanine:2- ATP-dependent ammonium pyrophosphohydrolase: (cytosine 2278 -C 5 )- kinase: DAK1 L-2- 20a reductase: semialdehyde cystathionine kinase: LCB3 steroid NTA1 dehydratase: a 3-oxooctanoyl- protein N-glycosylation phosphate phosphate biosynthesis TPS2 pyrimidine lyase: PDC1 carboxy-lyase: ARO10 indole-3-pyruvate L-phenylalanine:pyruvate vacuolar Lecithin phosphatidylserine alpha putative glucan N8- -trimethyltransferase: exopolyphosphatase: c]-lysine N- methyltransferase: aminoadipate dihydrouridine phosphate gamma- phosphatase: steroid YKL217W PHS1 IPT1 ALG6 COX15 RNR4 RNR1 deoxyribonucleotide nucleobases salvage II UDP kinase: YNK1 decarboxylase: methylthiobutanoate carboxy-lyase: PDC1 aminotransferase: ARO9oxoglutarate PHotoreactivation mannosidase: endo-1,3-beta-D- HAM1 DOT1 methyltransferase: methyltransferase: dihydroxyacetone MUM2 IME4 SLZ1 synthase: DUS4 YPR1 dehydrogenase: dehydrogenase: sphinganine reductase: reductase: amidase: [acp] 1-palmitoyl-sn-glycero- (yeast) processing in the ER isomerase: sirohydrochlorin phosphorylation adenine and THI3 phenylpyruvate 2-keto-3-methylvalerate carboxy-lyase: ARO10 aminotransferase: ARO8 transporter Repair cholesterol acyl sn-1 acylhydrolase: acetylspermidine 6 PPX1 kinase: DAK2 reductase: LYS2 [+ 2 isozymes] PUT2 lyase: CYS3 PHO13 D-glucopyranose uroporphyrinogen tyrosine degradation AMS1 glucosidase: SCW11 [+ 2 isozymes] a [histone H3] N RCM1 2278 CTM1 a 5,6- GUT2 kinase: YSR3 ERG27 ERG27 AMD2 YIL011W Glc Man PGI1 GTP dCMP adenosine carboxy-lyase: PDC1 (indol-3-yl)acetaldehyde 3-phenyl-2-oxopropanoate YCF1: YCF1 deficient: PHR1 transferase: LRO1 ATG15 oxidase: FMS1 6 6 a 5-methylcytosine 20a 3-phosphocholine phospholipid: lyso- cardiolipin 3 9 6-phosphate III synthase: HEM4 dADP 2-oxoisovalerate carboxy- ,N ,N -trimethyl- DHAP allysine dihydrouracil L-arabinopyranose 4-nitrophenol cycloeucalenol a 3-oxotetradecanoyl- mevalonate kinase: ERG12 GlcNAc -[protein] phosphoglucomutase: sirohydrochlorin thymidylate salvage VI 2-keto-3-methylvalerate glutathione in 25S rRNA glu YLR229C laurate phosphatidylcholine synthase: CRD1 Glc2 Man dGDP cytosine deaminase: FCY1 carboxy- lyase: PDC5 phenylpyruvate α-D- L-lysine-79 in tRNA gly YPR058W gly [acp domain within trans-docosan- 3 9 PGM1 ferrochelatase: MET8 kinase: kinase: CDC8 CTP synthase: URA8 carboxy-lyase: PDC5 indole-3-ethanol:NAD+ S-conjugate β a (3R)-3- acyltransferase: TAZ1 GlcNAc α-1,2- dADP dCDP lyase: PDC1 phenylpyruvate alcohol dehydrogenase oxidoreductase: SFA1 carboxy-lyase: ARO10 a 2'-deoxycytidine a 2-lysophosphatidylcholinea steryl-ester a fatty acid mannopyranose a 1,3- -D-glucan 4-acetamidobutanalpropane- a fatty acid synthase] 2-enoyl-CoA Ptd Gro (R)-5-phosphomevalonate glucosidase:2 putative phosphoglucomutase: YNK1 kinase: CTP synthase: URA7 adenosine decarboxylase: carboxy- 2-keto-3-methylvalerate IV: ADH4 L-tyrosine:2- transport: YBT1 in DNA 1,3-diamine reductase: TSC13 hydroxyoctanoyl- Lecithin 2 PGM2 uroporphyrinogen siroheme dCDP uracil indole-3-ethanol phenylpyruvate L-tyrosine:pyruvate YHR211W [acp] cholesterol acyl CWH41 glutamine-- α-D-glucopyranose chitosan biosynthesis ferroheme a YNK1 dTDP adenosine PDC5 lyase: PDC6 carboxy-lyase: PDC6 methionol:NAD+ carboxy-lyase: PDC1 oxoglutarate aminotransferase: ABC-type phosphomevalonate (glucosyl)-(mannosyl) - fructose-6- 1-phosphate decarboxylase: kinase: kinase: phosphoribosyltransferase: CTP kinase: oxidoreductase: SFA1 dehydrogenase: ADH5 aminotransferase: glutathione- gly YDL119C (3R)-3- transferase: LRO1 kinase: ERG8 9 HEM12 2-oxoisovalerate 2-methylbutanal phenylpyruvate ARO9 DNA combined with 2142 YDL035C a (3R)-3- (N-acetylglucosaminyl) phosphate YNK1 YNK1 FUR1 ADO1 phenylacetaldehyde indole-3-ethanol ARO8 S-conjugate 5,10-methylene- 5-amino-4- + + adenine an N-terminal L- an organic glyoxylate a 1,2-diacyl- hydroxyacyl- Glc Man UDP-glucose chitin carboxy- methionol dehydrogenase: ADH4 carboxy-lyase: PDC5 tetrahydromethanopterin imidazolecarboxyamide H H myristoyl-CoA exogenous DNA to form in 25S rRNA methamphetamine glutaminyl-[protein] Ins(1)P an aldehyde hydroperoxide ethylphosphate sn-glycerol lathosterone zymostenol hydroxytetradecanoyl- 3-oxo- -diphosphodolichol 2 9 2-methylbutanol:NAD+ transporter: BPT1 [acyl-carrier- 2 transaminase: pyrophosphorylase: chitin deacetylase: CDA1 dTTP dCTP lyase: PDC6 aldehyde dehydrogenase: ADH2 a recombinational junction 25S rRNA protein N-terminal NADPH- bifunctional AP-4-A NADPH- 3-ethylmalate 2,4-dienoyl- 3-keto- 3-keto- [acp domain within lignoceronyl-CoA (R)-mevalonate diphosphate glucosyltransferase: GlcNAc α-1,3- YMR084W oxidoreductase: SFA1 indole-3-ethanol phenylpyruvate 7-(2-hydroxy-3-amino- trans-aconitate 3- N,N-dimethylaniline 1D-myo-inositol 1- alkyl ethylphosphate dienelactone Daughter asp phosphatidate biosynthesis I protein] triacylglycerol biosynthesis glucosidase:2 UGP1 chitin deacetylase: CDA2 dehydrogenase: methionol:NAD 4-hydroxyphenylpyruvate a glutathione-S-conjugate TOPoisomerase: (adenine2142-N1)- glutamine dependent alcohol phosphorylase/ADP dependent alcohol synthase: MLS1 diacylglycerol CoA steroid steroid a fatty acid synthase] synthase: ELO3 (the dihydroxyacetone pathway) dehydratase: phosphatidylglycerol ALG8 coproporphyrinogen 2-methylbutanol dehydrogenase: ADH3 carboxy-lyase: PDC6 3-methyl-2-oxobutanoate adenine 3-oxooctadecanoyl- 3-methylcarboxypropyl) thiosulfate TOP3 SGS1 RMI1 methyltransferase: monooxygenase: monophosphate hydroperoxide phosphatase: kinase: DGK1 hydrolase: Specific serine YPL265W biosynthesis II (non-plastidic) a 2-lysophosphatidylcholine mevalonate diphosphate GTB1 ROT2 glucoseamine- UTP glucose- chitosan ALD4 oxidoreductase: ADH5 carboxy-lyase: PDC6 hydroxymethyltransferase: 3-oxopalmitoyl-CoA -wyosine TMT1 methyltransferase: FMO1 amidohydrolase: dehydrogenase: sulfurylase: APA2 dehydrogenase: reductase: AHP1 PHO8 3-ethylmalate YDL086W reductase: reductase: reductase: glu YOR046C (3R)-3- 3-oxolignoceroyl-CoA HTD2 decarboxylase: MVD1 6-phosphate oxidase: HEM13 dehydrogenase: ADH5 methionol indole-3-ethanol phenylacetaldehyde glutathione phosphoribosyltransferase: CoA synthase: synthase: ELO1 sulfurtransferase: [+ 2 isozymes] (E)-2- BMT2 NTA1 ADH6 phosphatase: INM1 ADH6 Expression: SPS19 ERG27 ERG27 hydroxyacyl-[acyl- sn-glycerol 3-phosphate GlcMan GlcNAc 1-phosphate cytochrome isobutanol:NAD+ aldehyde dehydrogenase: ADH2 4-hydroxyphenylpyruvate ECM31 APT2 ELO1 methyltransferase: RDL1 1 2142 ADP-sulfurylase: APA1 [+ 6 isozymes] synthase: DAL7 DSE4 mevalonate pyrophosphate -[protein]9 2 synthase: GFA1 uridylyltransferase: c biogenesis 2-methylbutanol reductase: ADH1 carboxy-lyase: PDC1 S-conjugate (methoxycarbonylmethyl) N -methyladenine myo-inositol carrier-protein] 3-oxo- dihydroxyacetone a (2E)-oct- DHAP oxidoreductase: dehydrogenase dehydrogenase: ADH4 indole-3-ethanol 2-phenylethanol:NAD+ γ PPM2 in 25S rRNA (2E,6E)-farnesal an alcohol ethanol 3-ethylmalate a β-D glucan lathosterol 2-enoyl-[acp] glycerol-3-phosphate-O- biotin-carboxyl carrier decarboxylase: MVD1 Glc Man YHL012W SFA1 (NAD+): ALD5 methionol -glutamate butenedioate dehydratase: lignoceroyl-CoA phosphate glycerol-3-phosphate protein assembly 1 9 dehydrogenase: ADH1 oxidoreductase: SFA1 hydrolase: dehydrogenase: GUT2 acyltransferase: GPT2 GlcNAc α-1,3- protoporphyrinogen isobutanol aldehyde:NAD+ 2-methylbutanol dehydrogenase: ADH3 THMPT HTD2 reductase: IFA38 acyltransferase: enoyl-[acyl- IPP 2 UDP-α-D-galactose cytochrome dehydrogenase: ADH3 2-phenylethanol ECM38 a (2E)-tetradec-2-enoyl- GPT2 carrier- glycerol-3-phosphate 1- phosphatidylethanolamine biosynthesis II glucosidase: glucosamine-6- oxidase: HEM14 dehydrogenase: oxidoreductase: dehydrogenase: ADH5 tyrosol (3R)-3- dolichyl-P-Glc:Glc phosphate N- UDP-glucose:dolichyl- biosynthesis c1 heme 2-methylbutanol methionol an (L-cysteinylglycine) [acp domain within protein] O-acyltransferase: SCT1 2 GTB1 ROT2 ADH5 ALD3 2-phenylethanol dehydrogenase: hydroxylignoceroyl-CoA dihydroxyacetone IPP isomerase: IDI1 Man GlcNAc -PP acetyltransferase: phosphate protoporphyrin IX lyase: CYT2 dehydrogenase: ADH2 -S-conjugate a fatty acid synthase] phosphate O- reductase: glycerol-3-phosphate-O- biotin:apoprotein 9 2 isobutanol aldehyde:NAD+ dehydrogenase: ADH4 ADH5 a CDP-1-acyl-2- 26 37 a 5'-dephospho- 3-hydroxy- a 2-lysophosphatidate -dolichol α-1,2- GNA1 glucosyltransferase: CCHL [+ 2 isozymes] L-lysine glutathione dehydroascorbate hν a dimer of adjacenthν sn-glycerol 3-phosphate N-(1-phenylpropan- a guanine a guanine a [protein]- 4-phosphooxy- [histone]- (S)-nicotine (2R)-homocitrate a bleomycin trans-dienelactone formaldehyde a [protein] C-terminal(3S)-3-hydroxy- D-serine roseoflavin lignoceroyl-CoA acyltransferase: ETR1 acyltransferase: GPT2 ser ligase: BPL1 glucosyltransferase: DIE2 UDP-glucose 4- protoheme dehydrogenase: oxidoreductase: degradation III 2-phenylethanol tyrosol arachidonoyl-glycerol thymidines in DNA 2-yl)hydroxylamine in tRNA in tRNA L-arginine L-threonine L-arginine [DNA] S-farnesyl-L-cysteineL-aspartate α-D-Glc-(1->2)-α-D-Glc-(1->3)-α-D- N-acetyl-D- ALG5 holocytochrome ADH4 ALD2 26 2 37 1 protein-arginine aryl-alcohol YAR027W dehydratase: SCT1 glycerol-3-phosphate 1- lysophosphatidic acid a [biotin carboxyl-carrier DMAPP α α epimerase: GAL10 ferrolyase: HEM15 dehydrogenase: ADH3 dehydrogenase: glycerol-3-phosphate 1- N,N-dimethylaniline tRNA (guanine -N )- Nicotinamide N- tRNA (guanine -N ) phosphoserine protein arginine N- N,N-dimethylaniline Leucine polynucleotide dienelactone formaldehyde riboflavin 6 Glc-(1->3)- -D-Man-(1->2)- -D-Man- MNS1: glucosamine c synthase: CYC3 arginine degradation ADH4 O-acyltransferase: SCT1 homoaconitate dehydrogenase: STErile: Serine D-serine PHS1 O-acyltransferase: SCT1 acyltransferase: LOA1 protein]-N -biotinyl-L-lysine isobutanol phenylacetate 2-phenylethanol CDP-diacylglycerol--inositol glutathione monooxygenase: dimethyltransferase: methylTransferase: -methyltransferase: omega-N transaminase: methyltransferase: monooxygenase: AminoPeptidases: 5'-hydroxyl- hydrolase: reductase: kinase: (1->2)-α-D-Man-(1->3)-[α-D-Man- MNS1 6-phosphate dehydrogenase: VI (arginase tyrosol an L-cysteine-S-conjugate deoxyribodipyrimidine deoxyribodipyrimidine glycerol-3-phosphate-O- invertase: FMO1 TRM1 NNT1 TRM5 methyltransferase: SER1 HSL7 FMO1 hydratase: LYS4 LAP3 AAD15 kinase: GRC3 YDL086W YLL056C STE14 Racemase: dehydratase: FMN1 lysophosphatidic acid dimethylallyltransferase: α α N-acetylglucosamine- protoheme oxidoreductase: ADH2 3-phosphatidyltransferase: dehydrogenase 2 1 SRY1 DSD1 trans-lignocer-2-enoyl-CoA a 2-lysophosphatidate (1->2)- -D-Man-(1->3)-[ -D-Man- Man GlcNAc - ADH3 leucine degradation III 2 pathway) photo-lyase: PHR1 photo-lyase: PHR1 acyltransferase: GPT2 SUC2 an N an N - HMT1 ω [+ 4 isozymes] a [protein] C-terminal acylglycerone- acyltransferase: ICT1 ERG20 8 2 phosphate 2-phenylethanol dehydrogenase: PIS1 (E)-N-(1-phenylpropan- 26 37 (3R)-3-hydroxy-2-oxo- nicotine- (1R,2S)- roseoflavin (1->2)-α-D-Man-(1->6)]-α-D-Man- [protein] (isomer (ascorbate): GRX1 dimethylguanine 1-methylnicotinamide methylguanine [protein]-N - S-farnesyl-L- pyruvate YLR004C phosphate lysophosphatidic acid 1-acyl-sn-gylcerol- β β mutase: PCM1 isobutanol dehydrogenase: ADH1 ADH3 2-ylidene)hydroxylamine methyl-L-arginine 4 phosphooxybutanoate 1'-N-oxide homoisocitrate benzaldehyde 5'-phosphate trans-lignocero- reductase: AYR1 a [biotin carboxyl- geranyl diphosphate (1->6)]- -D-Man-(1->4)- -D-GlcNAc- 8A B ) N-acetyl-α-D- dehydrogenase: N 6 -acetyl-L-lysine putative in tRNA in tRNA cysteine methyl ester 2-enoyl-CoA acyltransferase: LOA1 3-phosphate acyl bifunctional choline kinase/ carrier-protein dimer]- (1->4)-α-D-GlcNAc-diphosphodolichol 1,2,3 1,3 arginase: 2-phenylethanol tyrosol CMP transferase: SLC1 ethanolamine kinase: CKI1 6 glucosamine ADH2 leucine degradation L-leucine:2-oxoglutarate dehydrogenase: cystathionine L-ascorbate a 3-oxohexadecanoyl- reductase: TSC13 1-(long-chain acyl)-sn lysophosphatidic acid N -biotinyl-L-lysine ω,E,E-farnesyl diphosphate 1-phosphate CAR1 beta-lyase: [acp domain within -glycerol 3-phosphate acyltransferase: ICT1 ethanolamine kinase: EKI1 acetyl-CoA geranyl diphosphate dolichyl-diphospho- trehalose biosynthesis I isobutanol aminotransferase: BAT1 ADH2 synthase: ERG20 biosynthesis oligosaccharide-protein UDP-N- dehydrogenase: YHR112C a fatty acid synthase] 1-acyl-sn-gylcerol- carboxylase leu branched-chain amino tyrosol:NAD+oxidoreductase: O-phosphoethanolamine biotin glycosyltransferase: acetylglucosamine ADH1 acid transaminase: BAT2 L-cysteine ADH1 cysteine-S- a dimer of non-adjacent 4a-hydroxy-L- 7-(2-hydroxy-3-amino- an [apo BCAA adenine 645 an adenine 34 dTTP 4α-methyl ergosta- 3-oxo- 3-phosphate acyl phosphatidate subunit: ACC1 OST1 OST2 D-glucopyranose 6-phosphate L-leucine:2-oxoglutarate ornithine ν malonyl-CoA H + a 2-lysophosphatidate a 3'-phosphopolynucleotide 54 a quinone (2E,6E)-farnesyl transferase: SLC1 carboxylase: IPP pyrophosphorylase: 4-methyl-2-oxopentanoate aminotransferase: L-methionine degradation degradation II conjugate beta- h thymidine and 2'- erythro-5,6,7,8- 3-carboxypropyl)- dehydrogenase E2 protein] in 25S rRNA a uracil in tRNA in tRNA thiosulfate 8,14,25(27)-trienol diphosphate cerotoyl-CoA phosphatase: APP1 phosphoethanolamine acetyl-coenzymeACC1 OST4 OST5 OST6 QRI1 isobutanol aminotransferase: BAT1 4-tyrosol deoxycytidine in DNA tetrahydrobiopterin 37 Phe 6 25S rRNA NADPH- dTTP delta(14) 1,4-glucan-6- synthase: ELO3 phosphatidate A carboxylase dimethylallyltransferase: CAR2 I (to L-homocysteine) lyase: IRC7 1-phosphatidylinositol-wyosine 7-(2-hydroxy-3-amino- in tRNA N -dihydrolipoyl-L-lysinedihydrolipoamide polynucleotide Transfer RNA tRNA- coniferyl alcohol tRNA(adenine34) tRNA thiosulfate 4-coumarate diphosphatase: squalene thiol cytidyltransferase: ECT1 farnesyltranstransferase: ERG20 SWP1 WBP1 STT3 alpha,alpha-trehalose- branched-chain amino keto-isocaproate cysteine-S- 4α-hydroxytetrahydrobiopterin 3-carboxypropyl) lysophosphatidate 3'-phosphatase: (adenine645-N1)- Methyltransferase: dihydrouridine 20 acetyltransferase: deaminase: pseudouridine 31 NADPH:quinone dependent alcohol sulfurtransferase: decarboxylase: -sterol (1,4-glucano) oxidase: diacylglycerol phosphatase: DPP1 a 1,2-diacyl-sn-glycerol subunit: HFA1 geranyl chitin phosphate synthase: TPS1 acid transaminase: BAT2 oligo-1,6- 4-phosphate 5- phosphatase: PHM8 dehydrogenase: reductase: ZTA1 NPP1 -transferase: synthase: YJL145W 3-oxocerotoyl-CoA lysophosphatidic CDP-ethanolamine BTS1 dolichyl-diphospho- chitin decarboxylase: THI3 L-glutamate-5- conjugate β- deoxyribodipyrimidine fatty-acyl-CoA synthase dehydratase: MCO14 glucosidase: IMA4 -wyosine TPP1 methyltransferase: TRM2 synthase: SMM1 ATF1 TAD2 TAD3 synthase: PUS6 dehydrogenase: RDL1 FDC1 reductase: ERG9 ERO1 putative phosphatidate kinase (CTP): DGK1phosphatidate a [carboxyl-carrier diphosphate 4-methyl-2-oxopentanoate semialdehyde cystathionine proline degradation kinase: MSS4 LPD1 54 20 31 [+ 2 isozymes] GLC3 acid 6 oligosaccharide-protein synthase: lyase: STR3 photo-lyase: PHR1 system: FAS2 FAS1 [+ 4 isozymes] carboxycarbonylase: RRP8 a 5-methyluracil a 5,6-dihydrouracil a hypoxanthine a pseudouridine ADH6 α ERG24 cytidylyltransferase: TAM41 phosphatase: LPP1 protein dimer]-N - GGPP D-serine 5-acetamidovalerate methionine gamma- a [BCAA dehydrogenase E2 34 a semiquinone sulfite dTMP 4 -methyl ergosta- squalene R'C(R)S-S(R)CR' 3-oxo-cerotoyl- acyltransferase: ethanolaminephosphotransferase: glycosyltransferase: PPM2 6 in tRNA in tRNA in tRNAs 1-butanal a glycogen (3R)-3- CoA reductase: phosphatidate phosphatidate carboxybiotinyl-L-lysine CHS2 keto-isocaproate degradation adenosyltransferase: lyase: CYS3 protein] N -lipoyl-L-lysine in tRNA 8,25(27)-dienol hydroxyacyl-[acyl- LOA1 EPT1 OST3 OST2 [+ 3 isozymes] decarboxylase: THI3 3-methylbutanol:NAD+ a 2'-deoxycytidine IFA38 cytidylyltransferase: CDS1 phosphatase: PAH1 fatty acid biosynthesis initiation SWP1 OST1 OST5 trehalose-6-phosphate SAM1 L-cysteine proline α-D-glucopyranoseD-glucopyranose YBL069W carrier-protein] lysophosphatidic (animals and fungi, cytoplasm) oxidoreductase: SFA1 (S)-1-pyrroline- methionine desulfidase: in DNA dehydratase: acid a phosphatidylethanolamine STT3 OST4 WBP1 phosphatase: TPS2 3-methylbutanol 5-carboxylate adenosyltransferase: IRC7 dehydrogenase: a 1,2-diacyl-sn-glycerol D-serine 5-aminopentanoate PUT1 HTD2 acyltransferase: acetyl-CoA Glc Man GlcNAc -[protein] α,α-trehalose 3-methylbutanol:NAD+ dehydrogenase: ADH5 pyrroline-5- SAM2 (S)-1-pyrroline- a (2E)-hexadec-2-enoyl- 3-hydroxy- CDP-diacylglycerol-- 3 9 2 dehydratase: α a 1-phosphatidyl- ICT1 phospholipid: lyso- oxidoreductase: SFA1 3-methylbutanol carboxylate SAM 5-carboxylate a 6-(N-acetyl- -D-glucosaminyl)- cycloartenol N,N-dimethylaniline uroporphyrinogen-I (S)-ureidoglycolate a negatively (2R,3S)-3- dCTP (2E,4Z)-deca- (2S,3S)-2- ferroheme o [acp domain within cerotoyl-CoA glycerol-3-phosphate 3- phosphatidylcholine acetyl-CoA DSD1 1-phosphatidyl-1D-myo-inositol sn-glycerol 3-phosphate 1D-myo-inositol 2-hydroxyisobutyramide supercoiled DNA isopropylmalate 2,4-dienoyl-CoA methylcitrate YGR086C a fatty acid synthase] dehydratase: 1-acyl-sn- phosphatidyltransferase: acyl-CoA:diacylglycerol 3-methylbutanol dehydrogenase: ADH4 reductase: 3-phosphate ChiTinaSe: CTS2 succinate dCTP 2,4-dienoyl- gylcerol-3- acyltransferase: TAZ1 carboxylase: ACC1 3-methlbutanol PRO3 carboxymethylenebutenolidase: glycerol-3-phosphate 1- 1-phosphatidylinositol sterol 24-C- N,N-dimethylaniline uroporphyrinogen putative tRNA- ureidoglycolate TOPoisomerase: isopropylmalate dihydrofolate IMP 5'- diphosphatase: nitrilase: prpD heme a PHS1 PGS1 acyltransferase: DGA1 acetyl-CoA:[acyl- dehydrogenase: ADH5 glutarate L-serine exo-1,3-beta- O-acyltransferase: SCT1 4-kinase: PIK1 methyltransferase: phosphatidylinositol- monooxygenase: decarboxylase: amidase: AMD2 dihydrouridine 17 endochitinase: semialdehyde reductase: nucleotidase: CoA Homolog: synthase: phosphate acyl Lecithin cholesterol acetyl-coenzyme carrier protein] 3-methylbutanol dehydrogenase: ADH3 degradation N-acetylglucosaminylphosphatidylinositol endo-polygalacturonase: YDL086W hydrolase: DAL3 TOP1 isomerase: LEU1 CTS1 dehydrogenase: NPP1 reductase: NIT1 transferase: SLC1 a phosphatidylglycerophosphate acyl transferase: LRO1 A carboxylase, 3-methylbutanol semialdehyde L-glutamate-5- PGU1 glucanase: SPR1 glycerol-3-phosphate-O- [+ 2 isozymes] ERG6 3-phosphatase: YMR1 FMO1 HEM12 amidase: NTA1 synthase: DUS1 DFR1 ISN1 [+ 2 isozymes] PDH1 COX15 trans-cerot-2-enoyl-CoA transacylase: FAS1 dehydrogenase: ADH4 de-N-acetylase: GPI12 a 1-acyl-2-arachidonoyl- N,N-dimethylaniline- 2-hydroxy-2- 17 (2S)-2- UGA2 β SPS19 2-hydroxy-2- mitochondrial: HFA1 dehydrogenase: ADH2 SAH semialdehyde [+ 3 isozymes] acyltransferase: GPT2 a 5,6-dihydrouracil glyoxylate a relaxed DNA a 7,8-dihydrofolate -D- dCMP (2E)-dec-2- ferroheme a YKR014C a palmitoyl-[acp domain trans-cerot- a triacyl-sn-glycerol an acetyl-[acp domain 3-methlbutanol γ pyruvate phosphatidylinositol N-oxide methylpropanoate in tRNA isopropylmalate ribosylnicotinate methylpropanoate within a fatty acid synthase] phosphatidylglycerophosphatase: dehydrogenase: ADH3 [+ 2 isozymes] L-serine L-glutamate - 4-phosphate enoyl-CoA 2-enoyl-CoA GEP4 within a fatty acid synthase] S-adenosyl-L- semialdehyde α reductase: TSC13 3-methylbutanol 3-methylbutanol glutarate homocysteine deaminase: dehydrogenase: acetate -D-glucopyranose palmitoyl a phosphatidylglycerol acetoacetyl-[acp] dehydrogenase: ADH2 hydrolase: SAH1 2-aminoprop-CHA1 PUT2 transacylase: [+ 2 isozymes] 2-enoate YIR019C synthase: FAS2 glutamate glycine cleavage L-threonine FAS1 3-methylbutanol L-homocysteine glu a phospholipid a 1,2-diacyl- a supercoiled duplex DNA amphetamine a [protein]- (2R,3S)-3- wound RNA succinate ferulate a nitrile a phosphate ATP degradation to degradation IV sn-glycerol a polyphosphate L-arginine isopropylmalate semialdehyde monoester an acetoacetyl-[acp domain 2-oxoglutarate dna HeliCaSe: HCS1 endo- succinate UTP glutamine degradation I endopolyphosphatase: uroporphyrinogen-III N,N-dimethylaniline arginine N5 tRNA- 3-isopropylmalate RNA-dependent 5-fluorocytosine ferulate nitrilase: diphosphatase: alkaline ribokinase: adenylate glyoxylate palmitoyl-CoA within a fatty acid synthase] glycine thr 5-methyltetrahydropteroyltriglutamate- carboxymethylenebutenolidase: DNA 3'-5' helicase: SLD5 exodeoxyribonuclease polygalacturonase: C-methyltransferase: monooxygenase: phosphoenolpyruvate methyltransferase: dihydrouridine 16 dehydrogenase: TOPoisomerase: ATPase: RRP3 deaminase: semialdehyde decarboxylase: NIT3 cyclase: reductase: phospholipid:diacylglycerol homocysteine S- YDL086W V: EXO5 PPN1 carboxykinase: PCK1 TOP2 dehydrogenase: NPP1 phosphatase: RBK1 dehydrogenase PSF1 PSF3 PSF2 MCM2 polyphosphatase: DDP1 PGU1 MET1 FMO1 RMT2 synthase: DUS1 LEU2 [+ 10 isozymes] FCY1 FDC1 [+ 2 isozymes] PHO8 CYR1 SRV2 GOR1 NAD-dependent L-glutamate (decarboxylating) acyltransferase: LRO1 methyltransferase: MET6 MCM6 MCM4 MCM3 5 UGA2 [+ 2 isozymes] alanine degradation III dihydrolipoamide L-phenylalanine 5-chloromaleylacetate a 5'-phosphooligonucleotide D-galactopyranuronate [protein]-N - a negatively 4-vinylguaiacol a carboxylate cyclic-AMP glyoxylate glutamate degradation to 4- : GCV2 L-threonine glutamate SeMet MCM7 MCM5 CDC45 an oligophosphate methyl-L-arginine supercoiled DNA dehydrogenase: aminobutanoate dehydrogenase: aldolase: degradation synthase: GLT1 GDH2 LPD1 GLY1 I (aerobic) YDR387C 2-oxoglutarate glu pyridoxal 5'-phosphate pyruvate transaminase: ALT2 glutamate a [glycine-cleavage phe synthase: SNZ3 SNO3 alanine complex H protein] N 6 - pyridoxal 5'-phosphate decarboxylase: acetaldehyde gly α aminotransferase: aminomethyldihydrolipoyl- synthase: SNZ2 SNO2 2,5-dichloro-trans 2-chloro-cis- cytidine 2',3'-cyclic uridine 2'3'-cyclic 2-deoxy- -D- 47 2'-deoxycytidine CTP an organic GAD1 phosphatidylglycerolphosphate monophosphate monophosphate a uracil in tRNA 5-methylcytosine maltose a chitodextrin glyoxylate YLR310C ALT1 4-aminobutanoate L-lysine pyridoxal 5'-phosphate (1-oleoyl, 2-palmitoyl) -dienelactone dienelactone ribose 1-phosphate 2'-deoxycytidine CTP molecule pyruvate tyr synthase: SNO1 SNZ1 4-nitrobenzaldehyde 2',3'-cyclic-nucleotide 2',3'-cyclic-nucleotide 4-coumaryl alcohol SedoHeptulose 1,7- tRNA- glycerol 2- nitrilase: 3-methylbutanal IsoMAltase: trans cinamate putative putative glyoxylate carboxymethylenebutenolidase: carboxymethylenebutenolidase: 3-dehydrosphinganine 3-dehydrosphinganine 3'-phosphodiesterase: 3'-phosphodiesterase: phosphoribomutase: 47 5-methylcytosine deaminase: D-ribulokinase: diphosphatase: GMP synthase: GUA1 phosphatidylglycerophosphatase: reductase: YDL124W acetyltransferase: Bisphosphatase: dihydrouridine dehydrogenase: NIT1 CDD1 reductase: IMA2 decarboxylase: chitinase: cytochrome reductase: acetyl-CoA GEP4 YDL086W YDL086W NADPH-dependent alcohol reductase: TSC10 reductase: TSC10 CPD1 CPD1 PRM15 deaminase: FCY1 GCY1 [+ 6 isozymes] YDR109C NPP1 CTS2 aminomethyltransferase: [+ 8 isozymes] ATF1 SHB17 synthase: DUS3 [+ 2 isozymes]2'-deoxyuridine GRE2 [+ 2 isozymes] FDC1 P450: DIT2 YPL113C GCV1 dehydrogenase: ADH6 L-threo- 2'-UMP 2-deoxy-D-ribose a 5,6-dihydrouracil 47 dihydroxyacetone D-ribulose YMR017W 2-chloromaleylacetate sphinganine 5-phosphate coumaryl acetate in tRNA 3-phenylpropanoate 3-methylbutanol 5-phosphate CMP

a long- ferrichrome D-glucose quinidine chain fatty UDP-N- iron(III)- D-glucose ferrichrome A D-galactose glutamate methyl α-D-glucoside GPB1 acyl-CoA GMP a basic glutamate miltefosine acetyl-α-D- enterobactin crystal violet D-mannose ferrirubin triacetylfusarinine C quinidine D-fructose a pentapeptide ferrioxamine B a nucleoside ketoconazole ammonium acetate ammonium L-canavanine D-sorbitol D-sorbitol D-sorbitol D-sorbitol maltotriose glucosamine uracil complex 10-N-nonyl acridine orangedityrosine an D-glucose D-fructose amino acid triacetylfusarinine C ketoconazole D-galactose D-mannose a tetrapeptide glucosyl-oleandomycin uridine asp [+ 2 more] arsenic triglutathione taurocholate a glutathione- ammonium D-mannitol D-mannitol D-mannitol D-mannitol maltose a glutathione-S-conjugatea glutathione-S-conjugateS-conjugate peroxisomal oligomycin cefoperazone fatty acid fatty acid ABC DNF2- vectorial vectorial LEM3 P4- YML128C YLR332W YGL045W YDR276C YFL011W epsin epsin cofilin YDR099W YNR070W acylase acylase transporter YER060W-A YDR348C YAR023C YDR160W YKR100C YCL069W YER067W YBR086C YNL019C YEL004W YOL081W YPR149W YKL105C YBR052C YNL194C YPL158C YMR244C-A YLL005C YOL105C YGL225W YOR101W YFL051C YFR029W YNL047C YER056C YBR021W YLR343W YDR522C YER177W YPR159W YDR104C YLR266C YNL231C YOL158C YPR198W YBR180W YGR281W YDR342C YDL194W YKR105C YHL040C YHL047C YIL120W YLR081W YOL156W YJL212C YPR194C YLR266C YGR224W YEL065W YAL022C YPL006W RAX2 YGR152C YLR373C YOR047C YBR016W YAR028W YJL214W YJL062W YDL210W YPR032W YDR459C YMR192W YHL044W YBL042C SFXN1 YER119C YNL065W YGR041W YDR135C YLL048C YLL015W YNR002C YDR384C YOR378W ATPase YOL019W YHR048W YCL025C YER143W YPL004C YLR452C YKR039W YGL053W YPL279C YCR011C YEL063C YPL249C YBR068C YOR049C YNL090W YGR266W YJR158W YNR072W YDL245C YEL069C YDL247W YJR160C YBR298C YPL058C complex complex 2 complex 1 PXA1-PXA2 complex UDP-N- adenine uracil iron(III)- crystal violet D-glucose ferrichrome quinidine D-glucose 5-aminolevulinate quinidine D-sorbitol D-sorbitol D-sorbitol miltefosine methyl α-D-glucosidemethyl α-D-glucoside acetyl-α-D- enterobactin dityrosine D-mannose D-galactose glucosyl-oleandomycin ferrioxamine B a nucleoside a sphingolipid putrescine glutamate arsenic triglutathione taurocholate a glutathione- ammonium an amino D-mannitol D-mannitol D-mannitol D-sorbitol maltotriose maltotriose hypoxanthine 10-N-nonyl acridine orange an ferrichrome A ketoconazole asp glutamate acid a long-chain a long-chain a long- glucosamine GDP-α-D- guanine complex oligomycin D-fructose ferrirubin D-fructose cefoperazone 4-aminobutanoate ketoconazole a glutathione-S-conjugatea glutathione-S-conjugateS-conjugate a phospholipid D-mannitol maltose maltose fatty acid fatty acid chain fatty mannose cytosine triacetylfusarinine C D-mannose [+ 2 more] acyl-CoA

formate--tetrahydrofolate ligase: MIS1

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