Authors: Pallavi Subhraveti Anamika Kothari Quang Ong Ron Caspi An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane are shown on the membrane. Ingrid Keseler Peter D Karp Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Csac1394711Cyc: Candidatus Saccharibacteria bacterium RAAC3_TM7_1 Cellular Overview Connections between pathways are omitted for legibility. Tim Holland

TM7C00001G0420 TM7C00001G0109 TM7C00001G0953 TM7C00001G0666 TM7C00001G0203 TM7C00001G0886 TM7C00001G0113 TM7C00001G0247 TM7C00001G0735 TM7C00001G0001 TM7C00001G0509 TM7C00001G0264 TM7C00001G0176 TM7C00001G0342 TM7C00001G0055 TM7C00001G0120 TM7C00001G0642 TM7C00001G0837 TM7C00001G0101 TM7C00001G0559 TM7C00001G0810 TM7C00001G0656 TM7C00001G0180 TM7C00001G0742 TM7C00001G0128 TM7C00001G0831 TM7C00001G0517 TM7C00001G0238 TM7C00001G0079 TM7C00001G0111 TM7C00001G0961 TM7C00001G0743 TM7C00001G0893 TM7C00001G0630 TM7C00001G0360 TM7C00001G0616 TM7C00001G0162 TM7C00001G0006 TM7C00001G0365 TM7C00001G0596 TM7C00001G0141 TM7C00001G0689 TM7C00001G0273 TM7C00001G0126 TM7C00001G0717 TM7C00001G0110 TM7C00001G0278 TM7C00001G0734 TM7C00001G0444 TM7C00001G0019 TM7C00001G0381 TM7C00001G0874 TM7C00001G0318 TM7C00001G0451 TM7C00001G0306 TM7C00001G0928 TM7C00001G0622 TM7C00001G0150 TM7C00001G0439 TM7C00001G0233 TM7C00001G0462 TM7C00001G0421 TM7C00001G0220 TM7C00001G0276 TM7C00001G0054 TM7C00001G0419 TM7C00001G0252 TM7C00001G0592 TM7C00001G0628 TM7C00001G0200 TM7C00001G0709

TM7C00001G0025 TM7C00001G0846

TM7C00001G0163 TM7C00001G0142

TM7C00001G0895 TM7C00001G0930 Detoxification Carbohydrate Biosynthesis DNA combined with a 2'- di-trans,octa-cis a 2'- Degradation an L-methionyl- TM7C00001G0190 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) Nucleoside and Biosynthesis Macromolecule Modification superoxide a nucleoside triphosphate a ribonucleic acid deoxyribonucleoside [DNA] -undecaprenyl deoxyribonucleoside superpathway of adenosine superpathway of 5-aminoimidazole exogenous DNA to form a Met guanosine Aminoacyl-tRNA Charging [initiator tRNA ] TM7C00001G0751 de novo biosynthesis I ribonucleotide biosynthesis radicals degradation a recombinational junction 5'-triphosphate putative membrane diphosphate 5'-diphosphate CTP deoxyribonucleotides gluconeogenesis I sucrose biosynthesis I DNA-directed RNA Holliday junction DNA polymerase ribonucleotide- GDP-mannose biosynthesis tRNA processing arginine degradation V methionyl-tRNA de novo biosynthesis I polymerase subunit beta: resolvase YqgF: III, beta subunit: associated protease: Undecaprenyl-diphosphatase: diphosphate (from photosynthesis) tRNA charging (arginine deiminase pathway) superoxide formyltransferase: PRPP asparagine biosynthesis RAAC3_TM7C00001G0816 RAAC3_TM7C00001G0049 RAAC3_TM7C00001G0315 RAAC3_TM7C00001G0568 RAAC3_TM7C00001G0465 reductase TM7C00001G0112 superpathway of adenosine nucleotides de novo biosynthesis II asp IMP (S)-malate β-D-glucose Superoxide dismutase: RAAC3_TM7C00001G0515 putative 3-phospho- a polycistronic di-trans,octa-cis an N-formyl- subunit GDP 6-phosphate III (tRNA-dependent) DNA-directed Crossover junction [+ 4 isozymes] ATP-dependent Clp amidophosphoribosyltransferase: D-glycerate glucose-6-phosphate tRNA precursor arg RAAC3_TM7C00001G0472 TM7C00001G0287 CDP ribonucleotide- arg hydrogen RNA polymerase RuvC: [DNA] protease proteolytic subunit: -undecaprenyl L-methionyl- alpha: nrdA RAAC3_TM7C00001G0336 : Arginine-tRNA : RAAC3_TM7C00001G0817 phosphate [initiator tRNA met ] asp IMP 5-phospho-β- diphosphate reductase malate phosphoglycerate kinase: asp peroxide subunit beta': rpoC resolution of recombinationalRAAC3_TM7C00001G0182 ribonucleotide- ribonucleotide- ribonucleotide- RAAC3_TM7C00001G0357 RAAC3_TM7C00001G0382 an L-arginyl- Arginine deiminase: TM7C00001G0312 D-ribosylamine subunit beta: nrdF dehydrogenase: RAAC3_TM7C00001G0069 : a ribonucleic acid junction formation a peptide a peptide diphosphate diphosphate diphosphate F6P [tRNA Arg ] RAAC3_TM7C00001G0374 ribonucleotide- ytsJ RAAC3_TM7C00001G0840 Ribonuclease: of two intact strands reductase reductase reductase adenylo-succinate 13-DPG a tRNA Arg TM7C00001G0177 diphosphate reductase mannose-6- an L-aspartyl- RAAC3_TM7C00001G0840 subunit subunit subunit a tRNA precursor subunit alpha: nrdA phosphate isomerase: [tRNA Asn ] Ribonuclease: L-citrulline O beta: nrdF Ribonucleoside- alpha: nrdA beta: nrdF with a 5' extension 2 TM7C00001G0670 UDP dGDP RAAC3_TM7C00001G0309 RAAC3_TM7C00001G0840 a ribonucleoside triphosphate reductase: GAR oxaloacetate pyruvate Glutamyl-tRNA(Gln) adenylo-succinate and a long 3' trailer a tRNA precursor with diphosphate ribonucleotide- ribonucleotide- [+ 2 isozymes] RAAC3_TM7C00001G0699 ribonucleotide- ribonucleotide- amidotransferase subunit A: ornithine diphosphate diphosphate D-glyceraldehyde a 5' extension and TM7C00001G0032 DHAP α-D-mannose cys RAAC3_TM7C00001G0854 diphosphate diphosphate dGDP kinase: 3-phosphate a short 3' extension carbamoyltransferase: reductase reductase AMP 6-phosphate -tRNA ligase: reductase reductase RAAC3_TM7C00001G0466 an L-asparaginyl- RAAC3_TM7C00001G0375 RNase II TM7C00001G0536 subunit subunit RAAC3_TM7C00001G0712 Ribonuclease: + a 5-aminomethyl-2- a ribonucleoside -bisphosphate an L-cysteinyl- Asn (deoxynucleotides) [DNA] NAD F6P subunit subunit [tRNA ] (m) 34 degradation beta: nrdF alpha: nrdA FGAR guanosine deoxyribonucleotides de novo biosynthesis II aldolase: [tRNA Cys ] a tRNA precursor RAAC3_TM7C00001G0840 GTP H O thiouridine in tRNA pyruvate dGTP triphosphate alpha: nrdA beta: nrdF phosphoenolpyruvate DNA ligase: 2 tRNA (5-methylaminomethyl- mRNA glucosamine- AMP a tRNA Cys with a 5' extension carbamoyl- Ribonucleoside- dGTP RAAC3_TM7C00001G0862 peptidyl-tRNA : L-ornithine RAAC3_TM7C00001G0016 acid /vanadium- fructose-6- TM7C00001G0697 dCDP α-D-mannose a tRNA precursor with phosphate 2-thiouridylate)- pyruvate kinase: Ribonuclease: ribonucleotide- ribonucleotide- RAAC3_TM7C00001G0640 dependent haloperoxidase triphosphate reductase: fructose 1,6- a short 3' extension [+ 3 isozymes] methyltransferase: RAAC3_TM7C00001G0070 phosphate TM7C00001G0543 diphosphate diphosphate GDP 1-phosphate RAAC3_TM7C00001G0699 RAAC3_TM7C00001G0840 bisphosphate Ribonuclease: carbamate kinase: related protein: RAAC3_TM7C00001G0056 aminotransferase: reductase reductase phosphoenol a 2'- ADP mannose-1-phosphate RAAC3_TM7C00001G0840 lysine degradation I AMP NMN (deoxynucleotides) RAAC3_TM7C00001G0502 a 5-methylaminomethyl- dGDP a nucleoside 5'- FGAM asn RAAC3_TM7C00001G0377 (m) deoxyribonucleoside glmS subunit subunit 34 pyruvate 2-phospho-D-glycerate guanylyltransferase: + 2-thiouridine in tRNA D-glucosamine ribonucleotide- ribonucleotide- phosphate GDP H 5'-triphosphate monophosphate TM7C00001G0425 UTP dCTP beta: nrdF alpha: nrdA RAAC3_TM7C00001G0285 gln Phosphoribosylformylglycinamidine diphosphate diphosphate Glutamate-tRNA ligase: CO 6-phosphate TM7C00001G0848 α 2 lys ADP ATP synthase subunit a: ribonucleotide- cyclo-ligase: reductase subunit reductase GDP- -D- RAAC3_TM7C00001G0657 Ribonucleoside- deoxycytidine dUDP F6P an L-glutaminyl- an uncharged tRNA RAAC3_TM7C00001G0954 mannose Lysine decarboxylase RAAC3_TM7C00001G0680 diphosphate reductase alpha: nrdA subunit beta: nrdF [tRNA Gln ] triphosphate reductase: triphosphate deaminase: di-trans,octa-cis RNase III mRNA + + subunit beta: nrdF a tRNA Gln L-glutamine biosynthesis family protein: α a 2'- a guanine 37 H TM7C00001G0682 H RAAC3_TM7C00001G0699 RAAC3_TM7C00001G0727 [+ 7 isozymes] ribonucleotide- ribonucleotide- UDP- -D- AIR 3-phospho-D-glycerate glucose-6-phosphate RAAC3_TM7C00001G0858 -undecaprenyl processing deoxyribonucleoside met ATP synthase subunit a: ribonucleotide- ribonucleotide- ribonucleotide- diphosphate diphosphate II (tRNA-dependent) galactose thr ATP pyruvate dATP in tRNA TM7C00001G0661 isomerase: glutamine degradation I cadaverine phosphate substrate 5'-triphosphate RAAC3_TM7C00001G0680 diphosphate reductase diphosphate reductase Ribonuclease: tRNA (guanine-N(1)- + + dUTP diphosphate reductase reductase reductase subunit phosphoglycerate kinase: Undecaprenyl- Ribonucleoside- Methionine-R- H TM7C00001G0688 H RAAC3_TM7C00001G0357 Pentose Phosphate Pathways Sua5/YciO/YrdC/ pyruvate kinase: [+ 7 isozymes] subunit beta: nrdF subunit alpha: nrdA ATP subunit alpha: nrdA subunit beta: nrdF alpha: nrdA glt phosphate galactose RAAC3_TM7C00001G0840 )-methyltransferase: RAAC3_TM7C00001G0069 YwlC family protein: triphosphate reductase: sulfoxide reductase: deoxyuridine triphosphatase: UDP-N-acetyl-α-D- phosphotransferase: Ribonuclease 3: RAAC3_TM7C00001G0070 RAAC3_TM7C00001G0929 ribonucleotide- ribonucleotide- GTP gln RAAC3_TM7C00001G0699 1 RAAC3_TM7C00001G0386 + + RAAC3_TM7C00001G0727 β-D-glucose Glutamate-tRNA ligase: RAAC3_TM7C00001G0246 an N - H TM7C00001G0687 H diphosphate reductase diphosphate reductase 13-DPG mannosaminouronate biosynthesis glt pentose phosphate pathway (partial) RAAC3_TM7C00001G0281 RAAC3_TM7C00001G0937RNase III phosphoenol TM7C00001G0949 dGDP 6-phosphate Glutamate-tRNA ligase: RAAC3_TM7C00001G0657 CTP synthase: α-D-galactosyl- L-threonylcarbamoyladenylate dADP a ribonucleoside methylguanine 37 L-methionine- UMP a single- pyruvate dUMP ATP subunit alpha: nrdA subunit beta: nrdF dADP UDP-N-acetyl- RAAC3_TM7C00001G0657 an L-glutamyl- processing triphosphate an L-glutamyl- RAAC3_TM7C00001G0378 diphosphoundecaprenol stranded RNA in tRNA (R)-S-oxide + + α-D-glucosamine [tRNA Gln ] D-ribulose mRNA H TM7C00001G0681 H Ribonucleoside- [tRNA Glu ] Thymidylate synthase: UDP-N-acetylglucosamine 5-phosphate glt triphosphate reductase: dGDP kinase: triosephosphate isomerase: a tRNA glu Glutamyl-tRNA(Gln) RAAC3_TM7C00001G0731 dADP kinase: 2-epimerase: Ribonucleoside- dADP RAAC3_TM7C00001G0068 D-glyceraldehyde α-D-glucose Ribulose-phosphate H + TM7C00001G0686 H + TM7C00001G0711 Amine and Polyamine RAAC3_TM7C00001G0699 RAAC3_TM7C00001G0466 RAAC3_TM7C00001G0290 amidotransferase subunit A: (Gro-P) -Gro-P-ManNAc- 9 dTMP RAAC3_TM7C00001G0466 DHAP UDP-N-acetyl-α- Polymeric Compound Degradation n a guanine triphosphate reductase: 3-phosphate 6-phosphate 3-epimerase: CDP-glycerol L-1-glycerophosphorylethanolamine a uridine in tRNA thiamin phosphate Biosynthesis RAAC3_TM7C00001G0854 GlcNAc-PP-undecaprenol DL-allothreonine in tRNA a protein Thymidylate kinase: RAAC3_TM7C00001G0699 D-mannosamine RAAC3_TM7C00001G0865 an L-glutaminyl- CDP- Glycerophosphodiester H + TM7C00001G0680 H + UDP-N-acetyl-D-mannosamine serine /vanadium- tRNA (guanine-N(1)- biosynthesis RAAC3_TM7C00001G0726 dADP kinase: Gln D-xylulose D-erythrose glycogen degradation I : tRNA-dihydrouridine synthase: putative membrane dATP dGTP [tRNA ] glycerol:poly(Glycerophosphate) hydroxymethyltransferase: dependent haloperoxidase )-methyltransferase: RAAC3_TM7C00001G0466 fructose-bisphosphate dehydrogenase: ile 5-phosphate 4-phosphate RAAC3_TM7C00001G0690 associated protease: TM7C00001G0471 dTDP α glycerophosphotransferase: RAAC3_TM7C00001G0158 -D-glucose RAAC3_TM7C00001G0286 RAAC3_TM7C00001G0115 related protein: RAAC3_TM7C00001G0929 H + TM7C00001G0684 H + aldolase: a glycogen RAAC3_TM7C00001G0292 sn-glycerol an N 1 - RAAC3_TM7C00001G0568 1-phosphate ethanolamine a 5,6-dihydrouridine RAAC3_TM7C00001G0502 SAM UDP-N-acetyl-α-D- an L-isoleucyl- (Gro-P) -Gro-P-ManNAc- gly acetaldehyde 9 dTDP kinase: RAAC3_TM7C00001G0862 Transketolase protein: Transketolase protein: n 3-phosphate Ile CMP methylguanine mannosaminouronate [tRNA ] GlcNAc-PP-undecaprenol in tRNA thiamin a peptide RAAC3_TM7C00001G0466 dATP UTP-glucose-1-phosphate RAAC3_TM7C00001G0864 RAAC3_TM7C00001G0864 in tRNA H + TM7C00001G0683 H + a tRNA Ile TM7C00001G0772 dTTP uridylyltransferase: dAdoMet fructose 1,6- RAAC3_TM7C00001G0545 D-glyceraldehyde bisphosphate 3-phosphate an α-limit dextrin α UDP-N-acetylmuramoyl-L- RNase E mRNA a double a [protein]-L- : UDP- -D-glucose D-alanyl-D-alanine 2-oleoylglycerol CTP carbamoyl- DNA with lesion PAS protein alanyl-γ-D-glutamyl-L-lysine processing L-ornithine stranded DNA methionine RAAC3_TM7C00001G0701 Cell Structure Biosynthesis phosphate UDP-N-acetylmuramoyl- substrate diacylglycerol kinase excinuclease ABC subunit C: DNA gyrase subunit B: TM7C00001G0659 leu Ribonuclease: ornithine Methionine-R- S-methyl-5'- Leucine-tRNA ligase: tripeptide-D-alanyl- catalytic subunit: RAAC3_TM7C00001G0030 RAAC3_TM7C00001G0500 spermine RAAC3_TM7C00001G0840 carbamoyltransferase: sulfoxide reductase: thioadenosine peptidoglycan biosynthesis I (meso-diaminopimelate containing) RNase E RAAC3_TM7C00001G0761 F6P sucrose 6 F RAAC3_TM7C00001G0942 an L-leucyl- a debranched D- alanine ligase: RAAC3_TM7C00001G0375 Excinuclease ABC subunit A: DNA gyrase subunit A: RAAC3_TM7C00001G0386 maltotetraose a single- 1-oleyl-2-lyso- TM7C00001G0882 Leu α-limit dextrin processing RAAC3_TM7C00001G0043 RAAC3_TM7C00001G0501 a protein-L- -phosphate [tRNA ] UDP-N-acetyl- α RAAC3_TM7C00001G0943 stranded RNA CDP L-citrulline glucose-6-phosphate Leu UDP-N-acetyl- -D-muramoyl-L-alanyl- phosphatidate DNA without a negatively TM7C00001G0923 a tRNA product mRNA methionine- isomerase: α-D-glucosamine γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine lesion supercoiled DNA (R)-S-oxide RAAC3_TM7C00001G0357 UDP-N-acetylglucosamine : β-D-glucose α-D-glucose TM7C00001G0394 L-ascorbate biosynthesis V , Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis sucrose RAAC3_TM7C00001G0116 maltotriose UDP-N-acetyl- a type 2 histo-blood group a supercoiled 6-phosphate + a 1,2-diacyl- TM7C00001G0795 transformations I 1-phosphate α a peptide with a FMNH NAD(P) a DNA segment L-ascorbate biosynthesis IV UDP-N-acetyl-α- -D-glucosamine antigen precursor disaccharide 2 arg duplex DNA sn-glycerol val N-acetylglucosaminyl leader sequence β-D-glucose NADPH-dependent Recombinase: ATP-dependent Valyl-tRNA synthetase: D-glucosamine- signal peptidase I: flavodoxin/nitric diacylglycerol kinase β-D-glucose transferase: FMN reductase: RAAC3_TM7C00001G0078 DNA helicase PcrA: 6-phosphate tetrahydrofolate RAAC3_TM7C00001G0345 an L-valyl- enolpyruvate oxide synthase: catalytic subunit: RAAC3_TM7C00001G0629 RAAC3_TM7C00001G0549 6-phosphate Val RAAC3_TM7C00001G0385 recombinase: RAAC3_TM7C00001G0066 TM7C00001G0202 [tRNA ] UDP-N- α-D-glucose maltose N-acetyl-β-D-glucosaminyl- RAAC3_TM7C00001G0130 RAAC3_TM7C00001G0761 TM7C00001G0204 Val a leader sequence a peptide H + NAD(P)H FMN RAAC3_TM7C00001G0925 [+ 3 isozymes] a 1,2-diacyl- α-D-glucose a tRNA acetylpyruvoylglucosamine 6-phosphate UDP (1->6)-β-D-galactosyl-(1->4) nitric oxide L-citrulline α a DNA segment in a single sn-glycerol 6-phosphate -D-glucose 10-formyl- 5-formyl- reductase: 4-alpha-glucanotransferase: -N-acetyl-β-D-glucosaminyl-R gcv system: reverse orientation stranded DNA 3-phosphate 6-phosphate tetrahydrofolate tetrahydrofolate RAAC3_TM7C00001G0108 RAAC3_TM7C00001G0752 N 10 -formyl-tetrahydrofolate biosynthesis RAAC3_TM7C00001G0231 UDP-N-α-D- TM7C00001G0806 TM7C00001G0650 D-glucopyranose methenyltetrahydrofolate 5-formyltetrahydrofolate ala a ring-opened 7- a [protein] N-terminal- a uridine 38- a double-stranded β-D-glucose α-D-glucose acetylmuramate glt + cyclohydrolase: cyclo-ligase: ala FMNH NADP α-D-glucose ser alanyl-tRNA synthetase: methylguanine in DNA formyl-L-methionine 2 40 in tRNA a protein oligonucleotide 6-phosphate 1-phosphate formamidopyrimidine- RAAC3_TM7C00001G0100 RAAC3_TM7C00001G0696 UDP-N-acetylmuramate- peptide deformylase: NADPH-dependent putative membrane Glucose-6-phosphate 1-phosphate RAAC3_TM7C00001G0053 an L-alanyl- glutamate racemase: UTP-glucose-1-phosphate serine L-alanine ligase: DNA glycosylase: RAAC3_TM7C00001G0516 FMN reductase: tRNA pseudouridine synthase oligoribonuclease: [tRNA Ala ] associated protease: 1-dehydrogenase: TM7C00001G0140 UTP-glucose-1-phosphate serine RAAC3_TM7C00001G0582 β RAAC3_TM7C00001G0407 an N-terminal L- B: RAAC3_TM7C00001G0411 RAAC3_TM7C00001G0388 TM7C00001G0271 uridylyltransferase: hydroxymethyltransferase: 5,10- Ala RAAC3_TM7C00001G0243 -D-glucose RAAC3_TM7C00001G0385 RAAC3_TM7C00001G0366 hydroxymethyltransferase: a tRNA 2,6-diamino-4- formate RAAC3_TM7C00001G0568 uridylyltransferase: methylenetetrahydrofolate an apurinic site methionyl-[protein] + RAAC3_TM7C00001G0545 RAAC3_TM7C00001G0115 methenyltetrahydrofolate UDP-N- H NADPH FMN 38- 6-phospho RAAC3_TM7C00001G0115 glycogenolysis II hydroxy-5-(N-methyl) a pseudouridine a peptide a peptide a nucleoside 5'- RAAC3_TM7C00001G0545 dehydrogenase: acetylmuramoyl- D-glutamate within DNA D-glucono- UDP-α-D-glucose formamidopyrimidine 40 in tRNA monophosphate UDP-α-D-glucose gly RAAC3_TM7C00001G0100 L-alanine 1,5-lactone TM7C00001G0042 UDP-glucose 6- 5-methyl- 5,10- a glycogen β-D-glucose TM7C00001G0700 dehydrogenase: UDP-glucose 6- tetrahydrofolate methylenetetrahydrofolate UDP-N-acetylmuramoylalanine- asn 6-phosphate a [protein]- RAAC3_TM7C00001G0286 dehydrogenase: folate polyglutamylation D-glutamate ligase: a single β a 1,2-diacyl- D-gluconate a -D glucoside [DNA] CTP a cytosine in DNA L-tyrosine RAAC3_TM7C00001G0286 RAAC3_TM7C00001G0581 an α-limit dextrin stranded DNA sn-glycerol 6-phosphate UDP-α-D-glucuronate an L-asparaginyl- beta-glucosidase: diacylglycerol kinase α tetrahydrofolate : modification methylase, phosphate 6-phosphogluconate TM7C00001G0242 UDP- -D- a 5,10- [tRNA Asn ] a tetrahydrofolate tetrahydrofolate formate VII large subunit: RAAC3_TM7C00001G0619 RAAC3_TM7C00001G0045 catalytic subunit: dehydrogenase, TM7C00001G0326 glucuronate methylenetetrahydrofolate ser tRNA Asn UDP-N- 4-alpha-glucanotransferase: a 2'- HemK family protein: Protein-tyrosine-phosphatase: Folylpolyglutamate synthase/ Folylpolyglutamate synthase/ RAAC3_TM7C00001G0593 a non glucosylated RAAC3_TM7C00001G0761 decarboxylating: tetrahydrofolate biosynthesis acetylmuramoyl- RAAC3_TM7C00001G0752 β-D-glucose a 1,2-diacyl- RAAC3_TM7C00001G0553 RAAC3_TM7C00001G0402 meso- a single-stranded a ribonucleoside D-glucose acceptor deoxyribonucleoside [DNA] dihydrofolate synthase: dihydrofolate synthase: 10-formyl- 4 RAAC3_TM7C00001G0367 UDP-α-D-galacturonate : L-alanyl-- a α-limit dextrin sn-glycerol CDP an N -methylcytosine (2-amino-4-hydroxy- RAAC3_TM7C00001G0102 RAAC3_TM7C00001G0102 diaminopimelate oligodeoxyribonucleotide 5'-monophosphate 5'-monophosphate a [protein]- D-ribulose RAAC3_TM7C00001G0728 a 5,10- tetrahydrofolate D-glutamate with short branches 3-phosphate in DNA TM7C00001G0280 7,8-dihydropteridin-6- 4-aminobenzoate a tetrahydrofolate L-tyrosine 5-phosphate D-glucopyranuronate methylenetetrahydrofolate TM7C00001G0137 yl)methyl diphosphate gcv system: asp UDP-N-acetylmuramyl- Aspartyl-tRNA synthetase: α-D-galacturonate RAAC3_TM7C00001G0231 7,8-dihydropteroate tripeptide synthetase: a 2'- UDP-N-acetyl- a peptide with RNase G Cu 2+ ATPase P Cu 2+ an N 10 - RAAC3_TM7C00001G0256 a debranched (deoxynucleotides) lotaustralin glycerophosphoserine pyruvate 5-methyl- an L-aspartyl- RAAC3_TM7C00001G0350 (m) α-D-glucosamine an N-terminal degradation 1-phosphate 7,8-dihydrofolate α-limit dextrin deoxyribonucleotide aldehydo-D- Folylpolyglutamate synthase/ formyltetrahydrofolate [tRNA asp ] DNA ligase: beta-glucosidase: UDP-N-acetylglucosamine Glycerophosphodiester substrate mRNA tetrahydrofolate UDP-N- L-methioninemethionine TM7C00001G0633 glucuronate dihydrofolate synthase: Folylpolyglutamate synthase/ tRNA asp RAAC3_TM7C00001G0016 RAAC3_TM7C00001G0619 2-epimerase: phosphodiesterase: pyruvate kinase: TM7C00001G0849 acetylmuramoylalanyl- aminopeptidase, type I: Ribonuclease: RAAC3_TM7C00001G0102 dihydrofolate synthase: (2R)-2-hydroxy-2- RAAC3_TM7C00001G0290 RAAC3_TM7C00001G0158 RAAC3_TM7C00001G0070 D-glutamate-2, 6- [+ 3 isozymes] β-D-glucose RAAC3_TM7C00001G0526 RAAC3_TM7C00001G0840 5-formyl- serine RAAC3_TM7C00001G0102 a 2'- methylbutanenitrile N-acetyl-α-D- α-D-glucose UDP sn-glycerol D-galactopyranuronate tetrahydrofolate 7,8-dihydrofolate diaminopimelate Carbohydrate Degradation mannosamine ser a peptide met phosphoenol hydroxymethyltransferase: an N 10 - 1-phosphate deoxyribonucleotide 3-phosphate a single- ligase: murE D-alanine pyruvate L-gulonate 5-formyltetrahydrofolate RAAC3_TM7C00001G0115 formyltetrahydrofolate stranded RNA TM7C00001G0959 TM7C00001G0261 Thymidylate synthase: methylenetetrahydrofolatecyclo-ligase: dihydrofolate reductase: tyr sucrose degradation II (sucrose synthase) UDP-N- RAAC3_TM7C00001G0731 dehydrogenase: RAAC3_TM7C00001G0696 RAAC3_TM7C00001G0728 a long-linear RNase E aldehydo-D- RAAC3_TM7C00001G0100 an L-tyrosyl- acetylmuramoyl- D-glucopyranose UDP-N-acetyl- α an adenosine 37 RNase II poly-A 5,10- 5,10- sucrose a [protein]-L-asparagine α -D-glucose DMAPP an adenine in DNA pyruvate galacturonate tetrahydrofolate [tRNA Tyr ] L-alanyl-γ-D- α-D-glucosamine -D-glucan substrate mRNA degradation L-gulono- methylenetetrahydrofolate methenyltetrahydrofolate 6-phosphate in tRNA Tyr N-acetylglucosaminyl 4-alpha-glucanotransferase: substrate mRNA TM7C00001G0206 TM7C00001G0662 a tRNA glutamyl-meso-2,6- D-alanyl-D-alanine miaA: Ribonuclease: modification methylase, 1,4-lactone methenyltetrahydrofolate RAAC3_TM7C00001G0752 pyruvate kinase: diaminopimelate transferase: RAAC3_TM7C00001G0481 RAAC3_TM7C00001G0840 HemK family protein: Ribonuclease: cyclohydrolase: 4-aminobenzoate biosynthesis 6 37 RAAC3_TM7C00001G0070 RAAC3_TM7C00001G0629 a short glucan a short glucan N -dimethylallyladenosine RNase II RAAC3_TM7C00001G0553 RAAC3_TM7C00001G0840 RAAC3_TM7C00001G0100 a [protein]-N 4 -(N-acetyl-β-D- aldehydo-L-galactonate UDP-N-acetylmuramoyl- UDP-α-D-glucose UDP in tRNA AMP substrate with β-D-fructofuranose glucosaminyl)-L-asparagine a DNA 6- a single- phosphoenol 10-formyl- chorismate tripeptide-D-alanyl- no poly-A tail TM7C00001G0450 TM7C00001G0337 L-xylo-hex-3- tryptophan- UTP-glucose-1-phosphate methylaminopurine stranded RNA pyruvate di-trans,poly-cis-undecaprenyl geranylgeranyl tetrahydrofolate a tRNA Trp D- alanine ligase: ulono-1,4-lactone tRNA phosphate biosynthesis diphosphate biosynthesis RAAC3_TM7C00001G0943 uridylyltransferase: ligase: trpS 4-amino-4- an L-tryptophanyl- RAAC3_TM7C00001G0545 L-galactono-1,4-lactone (2E,6E)-farnesyl (2E,6E)-farnesyl Trp α IPP deoxychorismate [tRNA ] UDP-N-acetyl- α UDP-N-acetyl- -D-glucosamine an i antigen maltohexaose maltose a uracil in DNA carbamoyl- a cytosine in DNA reduced riboflavin a β-lactam TM7C00001G0321 -D-glucose L-canaline diphosphate diphosphate trp α phosphate TM7C00001G0391 di-trans,poly-cis- Geranylgeranyl -D-muramoyl- 1-phosphate N-acetylglucosaminyl 4-alpha-glucanotransferase: uracil-DNA glycosylase: L-ascorbate Aminodeoxychorismate : ornithine NADPH-dependent decaprenylcistransferase: pyrophosphate synthase: L-alanyl-γ-D- transferase: RAAC3_TM7C00001G0752 putative DNA methylase: Beta-lactamase protein: RAAC3_TM7C00001G0048 RAAC3_TM7C00001G0034 FMN reductase: D-mannose degradation carbamoyltransferase: di-trans,octa-cisuppS RAAC3_TM7C00001G0565 glutamyl-meso-2,6- di-trans,octa-cis RAAC3_TM7C00001G0629 β-D-glucose maltoheptaose an apyrimidinic RAAC3_TM7C00001G0591 RAAC3_TM7C00001G0417 a β-D-Gal-(1->4)-β-D-GlcNAc-(1->3)-[β-D- uracil RAAC3_TM7C00001G0375 RAAC3_TM7C00001G0385 -undecaprenyl GGPP Amino Acid Biosynthesis diaminopimeloyl- -undecaprenyl UDP site in DNA TM7C00001G0531 L-ascorbate 4-aminobenzoate α β β a 5-methylcytosine a substituted diphosphate D-alanyl-D-alanine α-D-glucose -D-mannose GlcNAc-(1->6)]- -D-Gal-(1->4)- -D-GlcNAc-R O-ureidohomoserine TM7C00001G0902 phosphate riboflavin β thr 6-phosphate 6-phosphate in DNA -amino acid arginine biosynthesis IV (archaebacteria) threonyl-tRNA synthetase: mannose-6- protein citrullination RAAC3_TM7C00001G0479 an L-threonyl- phosphate isomerase: [tRNA Thr ] RAAC3_TM7C00001G0309 cis-coumarinic a [protein]-L- TM7C00001G0106 a ribonucleic acid a 1,4-β-D-glucan glycerophosphoglycerol an oligopeptide oxaloacetate glt a [protein]- a tRNA Thr undecaprenyldiphospho- [+ 2 isozymes] acid-β-D-glucoside proline (ω = 180) TM7C00001G0884 beta-glucosidase: Glycerophosphodiester putative membrane L-arginine N-acetylmuramoyl-L- F6P F6P Ribonuclease: beta-glucosidase: peptidyl-prolyl cis- malate Arginine deiminase: RAAC3_TM7C00001G0619 phosphodiesterase: associated protease: alanyl-γ-D-glutamyl-meso RAAC3_TM7C00001G0840 RAAC3_TM7C00001G0619 trans isomerase: dehydrogenase: RAAC3_TM7C00001G0374 -2,6-diaminopimeloyl- a 3' phosphooligonucleotide a ribonucleoside β-D-glucose a 1,4-β-D-glucan RAAC3_TM7C00001G0158 RAAC3_TM7C00001G0568 TM7C00001G0277 a [protein]- β-D-glucose coumarinate RAAC3_TM7C00001G0608 ytsJ D-alanyl-D-alanine RNA 3'-phosphate sn-glycerol L-citrulline glycerol a peptide a peptide a [protein]-L- an [amino group N-acetylglucosaminyl 3-phosphate pyruvate TM7C00001G0897 ser proline (ω = 0) Metabolic Regulator Biosynthesis carrier protein]- transferase: C-terminal-γ- an L-seryl- RAAC3_TM7C00001G0629 TM7C00001G0750 (L-glutamyl) ser undecaprenyldiphospho- trehalose biosynthesis V [tRNA ] D-xylulose a negatively a (1->4)- nitric oxide ser a glucan D-glucopyranose an N-modified -L-glutamate a tRNA N-acetyl-(N- a 9S rRNA α-D-mannose α-D-glucan TM7C00001G0922 biosynthesis (plants) 5-phosphate GDP supercoiled DNA acetylglucosaminyl) 4-alpha-glucanotransferase: aminoacyl-[tRNA] a glycogen [LysW]-L-glutamate 5-kinase: putative : Ribonuclease: 1-phosphate peptidyl-tRNA hydrolase: alpha-amylase: RAAC3_TM7C00001G0377 muramoyl-L-alanyl- Inorganic Nutrient Metabolism RAAC3_TM7C00001G0265 RAAC3_TM7C00001G0752 RAAC3_TM7C00001G0840 mannose-1-phosphate DNA topoisomerase: TM7C00001G0467 arg γ RAAC3_TM7C00001G0640 RAAC3_TM7C00001G0753 -D-glutamyl-meso- D-glyceraldehyde maltotriose a glucan a single- guanylyltransferase: RAAC3_TM7C00001G0636 an [amino group acetyl phosphate a 5S rRNA an N-modified flavodoxin/nitric 2,6-diaminopimeloyl- sulfate activation 3-phosphate stranded RNA a tRNA RAAC3_TM7C00001G0285 a (1->4)- a maltodextrin carrier protein]- amino acid GDP-α-D- TM7C00001G0325 oxide synthase: pro D-alanyl-D-alanine phosphate utilization a relaxed DNA α-D-glucan C-terminal-γ- prolyl-tRNA synthetase: for sulfonation mannose RAAC3_TM7C00001G0130 in cell wall regeneration nitric oxide (5-phospho- RAAC3_TM7C00001G0569 an L-prolyl- TM7C00001G0660 sulfate L-glutamyl)- [tRNA Pro ] a phosphate Pro 4-methylumbelliferyl a plant soluble a single L-glutamate a tRNA a peptidoglycan monoester β-D-glucose 2+ (2E,6E)-farnesyl a maltooligosyl- acid phosphatase/vanadium- protoporphyrin IX Mg H O diphosphate protoheme IX TM7C00001G0160 glucoside heteroglycan 2 stranded DNA a peptide trehalose dimer (meso- diphosphate dependent haloperoxidase beta-glucosidase: 4-alpha-glucanotransferase: Mg chelatase, subunit ChlI: protoheme IX diaminopimelate APS Inorganic pyrophosphatase: aminopeptidase TM7C00001G0532 alpha-amylase: related protein: RAAC3_TM7C00001G0619 RAAC3_TM7C00001G0752 RAAC3_TM7C00001G0493 : DNA primase: containing) a plant soluble RAAC3_TM7C00001G0870 P: pepP RAAC3_TM7C00001G0753 an [amino group RAAC3_TM7C00001G0502 β maltose Mg- cyoE RAAC3_TM7C00001G0392 Phenylalanine-tRNA Adenylylsulfate kinase: -D-glucose 4-methylumbelliferone heteroglycan phosphate H + a proteinogenic carrier protein]- phosphate protoporphyrin a peptide α α RAAC3_TM7C00001G0291 heme o a short RNA amino acid TM7C00001G0067 , -trehalose γ ligase beta subunit: C-terminal- - segment TM7C00001G0003 RAAC3_TM7C00001G0875 a peptidoglycan (L-glutamate 5- phe PAPS semialdehyde-2- Phenylalanine-tRNA ligase: with D,D cross- yl)-L-glutamate RAAC3_TM7C00001G0881 an L-phenylalanyl- links (meso- a (1,6)-α-D-glucosyl- 2-keto-D- CTP maltohexaose β-D-glucose linamarin a RNA-DNA hybrid Phe diaminopimelate phosphate acquisition (1,4)-α-glucan a protein TM7C00001G0449 [tRNA ] gluconate deoxycytidine TM7C00001G0333 a tRNA Phe containing) alpha-amylase: 4-alpha-glucanotransferase: beta-glucosidase: : 2,5-diketo-D-gluconic triphosphate deaminase: RAAC3_TM7C00001G0753 RAAC3_TM7C00001G0752 RAAC3_TM7C00001G0619 protease Do: a phosphate α RAAC3_TM7C00001G0489 acid reductase: an [amino group a (1,6)- -D-glucosyl- acetone RAAC3_TM7C00001G0552 RAAC3_TM7C00001G0727 monoester Alcohol Degradation α a malto-oligosaccharide maltose maltopentaose β-D-glucose a nucleoside 5'- RAAC3_TM7C00001G0031 carrier protein]- acid phosphatase/vanadium- (1,4)- -glucan cyanohydrin DNA UTP monophosphate a peptide a peptide TM7C00001G0171 C-terminal-γ- dependent haloperoxidase 2,5-didehydro- TM7C00001G0888 a peptidoglycan glycerophosphodiester degradation D-gluconate hydrogen (L-ornithyl) met related protein: methionyl-tRNA synthetase: carbonate -L-glutamate RAAC3_TM7C00001G0502 RAAC3_TM7C00001G0062 an L-methionyl- phosphate [elongator a glycerophosphodiester α a (1->4)- UTP starch a maltodextrin -D-glucose α scopolin an alkylated DNA starch TM7C00001G0794 TM7C00001G0932 Met Glycerophosphodiester -D-glucan a tRNA Met tRNA ] a peptidoglycan phosphodiesterase: alpha-amylase: 4-alpha-glucanotransferase: alpha-amylase: beta-glucosidase: DNA-3-methyladenine CTP synthase: alpha-amylase: carbamoyl- RAAC3_TM7C00001G0158 RAAC3_TM7C00001G0753 RAAC3_TM7C00001G0752 RAAC3_TM7C00001G0753 RAAC3_TM7C00001G0619 glycosylase II: RAAC3_TM7C00001G0378 L-ornithine a (1->4)- sn-glycerol RAAC3_TM7C00001G0037 RAAC3_TM7C00001G0753 phosphate D-glucopyranose maltose a maltodextrin maltose a maltodextrin maltohexaose α scopoletin β-D-glucose Secondary Metabolite 3-phosphate -D-glucan an alkylated CTP TM7C00001G0673 [DNA] a large- TM7C00001G0159 Degradation nucleobase ornithine branched glucan a tRNA Lys carbamoyltransferase: lysyl-tRNA synthetase: taxiphyllin bioactivation RAAC3_TM7C00001G0375 RAAC3_TM7C00001G0572 an L-lysyl- a β-D-glucan with a β Lys DHAP maltopentaose D-glucopyranose neolinustatin linustatin starch -D-cellobiose TM7C00001G0551 [tRNA ] taxiphyllin C3-substituted glucose TM7C00001G0460 lys beta-glucosidase: 4-alpha-glucanotransferase: Endo-1,3(4)-beta-glucanase: beta-glucosidase: beta-glucosidase: alpha-amylase: beta-glucosidase: L-citrulline RAAC3_TM7C00001G0619 RAAC3_TM7C00001G0752 RAAC3_TM7C00001G0645 RAAC3_TM7C00001G0619 RAAC3_TM7C00001G0619 RAAC3_TM7C00001G0753 RAAC3_TM7C00001G0619 4-hydroxybenzaldehyde hydrogen cyanide maltose maltotetraose a β-D glucan a β-D glucan β-D-glucose lotaustralin β-D-glucose linamarin glucose maltose TM7C00001G0186 β-D-glucose TM7C00001G0876 glycine biosynthesis I histidyl-tRNA his L-arginino- synthetase: succinate hisS an L-histidyl- transporter ser [tRNA His ] serine TM7C00001G0626 a tRNA His hydroxymethyltransferase: RAAC3_TM7C00001G0115 TM7C00001G0748 arg gly TM7C00001G0188 gly glycyl-tRNA synthetase: TM7C00001G0329 RAAC3_TM7C00001G0601 a glycyl-[tRNA Gly ] TM7C00001G0376 a tRNA Gly

TM7C00001G0205

TM7C00001G0721

TM7C00001G0706 TM7C00001G0447 TM7C00001G0585 TM7C00001G0257 TM7C00001G0266 TM7C00001G0232 TM7C00001G0567 TM7C00001G0026 TM7C00001G0225 TM7C00001G0935 TM7C00001G0358 TM7C00001G0125 TM7C00001G0340 TM7C00001G0096 TM7C00001G0332 TM7C00001G0463 TM7C00001G0907 TM7C00001G0834 TM7C00001G0703 TM7C00001G0625 TM7C00001G0370 TM7C00001G0270 TM7C00001G0011 TM7C00001G0914 TM7C00001G0887 TM7C00001G0288 TM7C00001G0488 TM7C00001G0379 TM7C00001G0443 TM7C00001G0643 TM7C00001G0095 TM7C00001G0455 TM7C00001G0853 TM7C00001G0445 TM7C00001G0885 TM7C00001G0679 TM7C00001G0210 TM7C00001G0883 TM7C00001G0212 TM7C00001G0653 TM7C00001G0241 TM7C00001G0114 TM7C00001G0541 TM7C00001G0249 TM7C00001G0133 TM7C00001G0017 TM7C00001G0896 TM7C00001G0215 TM7C00001G0475 TM7C00001G0262 TM7C00001G0857 TM7C00001G0169 TM7C00001G0222 TM7C00001G0134 TM7C00001G0458 TM7C00001G0796 TM7C00001G0073 TM7C00001G0334 TM7C00001G0476 TM7C00001G0075 TM7C00001G0384 TM7C00001G0050 TM7C00001G0641 TM7C00001G0441 TM7C00001G0183 TM7C00001G0550 TM7C00001G0542 TM7C00001G0324 TM7C00001G0316 TM7C00001G0498 TM7C00001G0495 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.