UNMC Human Genetics Laboratory where excellence is dominant | Munroe-Meyer Institute | Omaha, Nebraska | 402-559-5070 | unmc.edu/geneticslab Hereditary Cancer Testing Services Gene Panels v19.0

Our Hereditary Cancer Panels analyze a carefully selected library of genes for genetic variants which are known to predispose a person to particular types of cancer, or, in some cases, to noncancerous conditions. Identifying a causative (pathogenic) genetic variant in the genes included in each panel can provide medically actionable results, including treatment and/or risk reduction. Additionally, this information allows for targeted genetic screening of at-risk family members.

METHODS Each panel includes two components: TURNAROUND TIME Results are available within 14 days • Sequencing analysis using a customized next generation for all hereditary cancer panels.* sequencing library The Breast9 panel is available for a 7 day turnaround time in special • High resolution (exon-specific) deletion/duplication analysis circumstances. Please contact the using a customized oligonucleotide array laboratory with questions regarding this STAT option. AVAILABLE PANELS * Results are available in under 4 weeks –– Breast2 for the comprehensive panel. –– Breast9 GENETIC COUNSELING –– Breast|Ovarian|Uterine28 Genetic counselors serve as a vital link between the laboratory and the –– Colorectal23 clinician, ultimately making the entire –– Endocrine|Paraganglioma-Pheochromocytoma17 genetic testing process easier and more meaningful for the ordering –– Neuro17 provider. In addition, these licensed –– Pancreatic14 and board-certified professionals bring their clinical expertise to –– Renal19 all facets of testing, from assay –– Comprehensive63 development to result interpretation. UNMC Human Genetics Laboratory Omaha, Nebraska | 402-559-5070 unmc.edu/geneticslab v18.3a GENE LISTS Hereditary Cancer Gene Panels including sequencing and deletion/duplication analysis

Breast2 BRCA1 BRCA2

Breast9 ATM BRCA1 BRCA2 CDH1 CHEK2 PALB2 PTEN STK11 TP53

BreastIOvarianIUterine28 ABRAXAS1 BRCA1 CDH1 EPCAM MRE11 MUTYH PALB2 RAD50 SMARCA4 XRCC2 ATM BRCA2 CHEK2 FANCC MSH2 ^ NBN PMS2 ^ RAD51C STK11 BARD1 BRIP1 DICER1 MLH1 MSH6 NF1 PTEN RAD51D TP53

Colorectal23 APC BLM CHEK2 GREM1 MSH3 NTHL1 POLE STK11 ATM BMPR1A EPCAM MLH1 MSH6 PMS2 ^ PTEN TP53 AXIN2 CDH1 GALNT12 MSH2 ^ MUTYH POLD1 SMAD4

EndocrineIParaganglioma-Pheochromocytoma17 CDC73 MEN1 PRKAR1A RET SDHAF2 SDHC TMEM127 TSC1 VHL MAX NF1 PTEN SDHA SDHB SDHD TP53 TSC2

Neuro17 ALK MEN1 MSH2 NBN NF2 PMS2 ^ SUFU TSC1 VHL APC MLH1 MSH6 NF1 PHOX2B PTCH1 TP53 TSC2

Pancreatic14 APC BRCA1 CDKN2A MLH1 MSH6 PMS2 ^ TP53 ATM BRCA2 EPCAM MSH2 ^ PALB2 STK11 VHL

Renal19 CDC73 FH MET MLH1 MSH6 PTEN SDHB SDHD TSC1 VHL EPCAM FLCN MITF MSH2 ^ PMS2 ^ SDHA SDHC TP53 TSC2

Comprehensive63 ABRAXAS1 BMPR1A CHEK2 GREM1 MSH2 ^ NTHL1 PTCH1 SDHAF2 SUFU ALK BRCA1 DICER1 MAX MSH3 PALB2 PTEN SDHB TMEM127 APC BRCA2 EPCAM MEN1 MSH6 PHOX2B RAD50 SDHC TP53 ATM BRIP1 FANCC MET MUTYH PMS2 ^ RAD51C SDHD TSC1 AXIN2 CDC73 FH MITF NBN POLD1 RAD51D SMAD4 TSC2 BARD1 CDH1 FLCN MLH1 NF1 POLE RET SMARCA4 VHL BLM CDKN2A GALNT12 MRE11 NF2 PRKAR1A SDHA STK11 XRCC2

^ Deletion/duplication and rearrangement analyses cannot be performed for indicated genes on a buccal specimen.