Apheresis Donation This Quick Reference Guide Will Help You Identify the Best Donation for Your Unique Blood Type

Total Page：16

File Type：pdf, Size：1020Kb

Apheresis Donation This quick reference guide will help you identify the best donation for your unique blood type. Donors now have the opportunity to make an apheresis (ay-fur-ee-sis) donation and donate just platelets, red cells, or plasma at blood drives. These individual components are vital for local patients in need. Platelets Control Bleeding Red Cells Deliver Oxygen Plasma transports blood cells & controls bleeding Donation Type Blood Types Requirements Donation Time A+, B+, O+ Over 75% of population has one of these blood types. Platelet Donation: Be healthy, weigh at least 114 lbs 2 hours cancer & surgery patients no aspirin for 48 hours Platelets only last five days after donation so the need is constant. O-, O+, A-, B- Special height, weight, Double Red: O-Negative is the 1 hour and hematocrit requirements. surgery, trauma patients, universal red cell donor. +25 min Please call us or see a staff member accident, & burn victims Only 17% of population has one of these negative blood types Plasma: AB+, AB- Trauma patients, burn Universal Plasma Donors 1 hour Be healthy, weigh at least 114 lbs victims, & patients with +30 min serious illness or injuries Only 4% of population How Apheresis works: Blood is drawn from the donor’s arm and the components are separated. Only the components being donated are collected while the remaining components are safely returned to the donor How to Schedule an Appointment: Please call 800-398-7888 or visit schedule.bloodworksnw.org. Walk-ins are also welcome at some blood drives, so be sure to ask our staff when you stop in. For more information on our mobile apheresis program, please visit www.bloodworksnw.org/mobileplatelets.

Copy Link

Recommended publications

Hemolytic Disease of the Newborn
Intensive Care Nursery House Staff Manual Hemolytic Disease of the Newborn INTRODUCTION and DEFINITION: Hemolytic Disease of the Newborn (HDN), also known as erythroblastosis fetalis, isoimmunization, or blood group incompatibility, occurs when fetal red blood cells (RBCs), which possess an antigen that the mother lacks, cross the placenta into the maternal circulation, where they stimulate antibody production. The antibodies return to the fetal circulation and result in RBC destruction. DIFFERENTIAL DIAGNOSIS of hemolytic anemia in a newborn infant: -Isoimmunization -RBC enzyme disorders (e.g., G6PD, pyruvate kinase deficiency) -Hemoglobin synthesis disorders (e.g., alpha-thalassemias) -RBC membrane abnormalities (e.g., hereditary spherocytosis, elliptocytosis) -Hemangiomas (Kasabach Merritt syndrome) -Acquired conditions, such as sepsis, infections with TORCH or Parvovirus B19 (anemia due to RBC aplasia) and hemolysis secondary to drugs. ISOIMMUNIZATION A. Rh disease (Rh = Rhesus factor) (1) Genetics: Rh positive (+) denotes presence of D antigen. The number of antigenic sites on RBCs varies with genotype. Prevalence of genotype varies with the population. Rh negative (d/d) individuals comprise 15% of Caucasians, 5.5% of African Americans, and <1% of Asians. A sensitized Rh negative mother produces anti-Rh IgG antibodies that cross the placenta. Risk factors for antibody production include 2nd (or later) pregnancies*, maternal toxemia, paternal zygosity (D/D rather than D/d), feto-maternal compatibility in ABO system and antigen load. (2) Clinical presentation of HDN varies from mild jaundice and anemia to hydrops fetalis (with ascites, pleural and pericardial effusions). Because the placenta clears bilirubin, the chief risk to the fetus is anemia. Extramedullary hematopoiesis (due to anemia) results in hepatosplenomegaly.
[Show full text]
Association Between ABO and Duffy Blood Types and Circulating Chemokines and Cytokines
Genes & Immunity (2021) 22:161–171 https://doi.org/10.1038/s41435-021-00137-5 ARTICLE Association between ABO and Duffy blood types and circulating chemokines and cytokines 1 2 3 4 5 6 Sarah C. Van Alsten ● John G. Aversa ● Loredana Santo ● M. Constanza Camargo ● Troy Kemp ● Jia Liu ● 4 7 8 Wen-Yi Huang ● Joshua Sampson ● Charles S. Rabkin Received: 11 February 2021 / Revised: 30 April 2021 / Accepted: 17 May 2021 / Published online: 8 June 2021 This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021, corrected publication 2021 Abstract Blood group antigens are inherited traits that may play a role in immune and inflammatory processes. We investigated associations between blood groups and circulating inflammation-related molecules in 3537 non-Hispanic white participants selected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Whole-genome scans were used to infer blood types for 12 common antigen systems based on well-characterized single-nucleotide polymorphisms. Serum levels of 96 biomarkers were measured on multiplex fluorescent bead-based panels. We estimated marker associations with blood type using weighted linear or logistic regression models adjusted for age, sex, smoking status, and principal components of p 1234567890();,: 1234567890();,: population substructure. Bonferroni correction was used to control for multiple comparisons, with two-sided values < 0.05 considered statistically significant. Among the 1152 associations tested, 10 were statistically significant. Duffy blood type was associated with levels of CXCL6/GCP2, CXCL5/ENA78, CCL11/EOTAXIN, CXCL1/GRO, CCL2/MCP1, CCL13/ MCP4, and CCL17/TARC, whereas ABO blood type was associated with levels of sVEGFR2, sVEGFR3, and sGP130.
[Show full text]
Blood Product Replacement: Obstetric Hemorrhage
CMQCC OBSTETRIC HEMORRHAGE TOOLKIT Version 2.0 3/24/15 BLOOD PRODUCT REPLACEMENT: OBSTETRIC HEMORRHAGE Richard Lee, MD, Los Angeles County and University of Southern California Medical Center Laurence Shields, MD, Marian Regional Medical Center/Dignity Health Holli Mason, MD, Cedars-Sinai Medical Center Mark Rollins, MD, PhD, University of California, San Francisco Jed Gorlin, MD, Innovative Blood Resources/Memorial Blood Center, St. Paul, Minnesota Maurice Druzin, MD, Lucile Packard Children’s Hospital Stanford University Jennifer McNulty, MD, Long Beach Memorial Medical Center EXECUTIVE SUMMARY • Outcomes are improved with early and aggressive intervention. • Both emergency blood release and massive transfusion protocols should be in place. • In the setting of significant obstetric hemorrhage, resuscitation transfusion should be based on vital signs and blood loss and should not be delayed by waiting for laboratory results. • Calcium replacement will often be necessary with massive transfusion due to the citrate used for anticoagulation in blood products. • During massive transfusion resuscitation, the patient’s arterial blood gas, electrolytes, and core temperature should be monitored to guide clinical management and all transfused fluids should be warmed; direct warming of the patient should be initiated as needed to maintain euthermia and to avoid added coagulopathy. BACKGROUND AND LITERATURE REVIEW After the first several units of packed red blood cells (PRBCs) and in the face of continuing or worsening hemorrhage, aggressive transfusion therapy becomes critical. This report covers the experience with massive transfusion protocols. Lessons from military trauma units as well as civilian experience with motor vehicle accidents and massive obstetric hemorrhage have identified new principles such as earlier use of plasma (FFP/thawed plasma/plasma frozen within 24 hours/liquid plasma) and resuscitation transfusion while laboratory results are pending.
[Show full text]
Blood Product Modifications: Leukofiltration, Irradiation and Washing
Blood Product Modifications: Leukofiltration, Irradiation and Washing 1. Leukocyte Reduction Definitions and Standards: o Process also known as leukoreduction, or leukofiltration o Applicable AABB Standards, 25th ed. Leukocyte-reduced RBCs At least 85% of original RBCs < 5 x 106 WBCs in 95% of units tested . Leukocyte-reduced Platelet Concentrates: At least 5.5 x 1010 platelets in 75% of units tested < 8.3 x 105 WBCs in 95% of units tested pH≥6.2 in at least 90% of units tested . Leukocyte-reduced Apheresis Platelets: At least 3.0 x 1011 platelets in 90% of units tested < 5.0 x 106 WBCs 95% of units tested pH≥6.2 in at least 90% of units tested Methods o Filter: “Fourth-generation” filters remove 99.99% WBCs o Apheresis methods: most apheresis machines have built-in leukoreduction mechanisms o Less efficient methods of reducing WBC content . Washing, deglycerolizing after thawing a frozen unit, centrifugation . These methods do not meet requirement of < 5.0 x 106 WBCs per unit of RBCs/apheresis platelets. Types of leukofiltration/leukoreduction o “Pre-storage” . Done within 24 hours of collection . May use inline filters at time of collection (apheresis) or post collection o “Pre-transfusion” leukoreduction/bedside leukoreduction . Done prior to transfusion . “Bedside” leukoreduction uses gravity-based filters at time of transfusion. Least desirable given variability in practice and absence of proficiency . Alternatively performed by transfusion service prior to issuing Benefits of leukoreduction o Prevention of alloimmunization to donor HLA antigens . Anti-HLA can mediate graft rejection and immune mediated destruction of platelets o Leukoreduced products are indicated for transplant recipients or patients who are likely platelet transfusion dependent o Prevention of febrile non-hemolytic transfusion reactions (FNHTR) .
[Show full text]
Blood Type and Transplantation & A2 Donor to B Recipient
Page 1 of 2 Blood Type and Transplantation Information for Kidney Transplant Patients Does blood type matter in transplantation? Everyone waiting for a transplant has their blood typed. You will have one of four blood types: O, A, B or AB. Your blood type is determined by the antigens that are present on your blood cells. These antigens are A or B. These antigens will be found both in your blood and on your organs. What antigen does each blood type have? Blood type O Blood type A Blood type B Blood type AB have no have A antigens. have B antigens. have both A O antigens. A B AB and B antigens. How does my body react to antigens? Your body will react to antigens that are different than your own by attacking with antibodies. Antibodies are proteins created by your immune system to attack anything that does not belong. Antibodies are the soldiers in your body’s army protecting you from foreign invasions such as viruses. Unfortunately, the antibodies cannot tell the difference between harmful viruses and beneficial transplanted organs. What blood type will my donor be? Transplants can occur between all blood types. However, when the donor’s blood type is different than yours and there are different antigens being transplanted on your new organ, your antibodies will be triggered and attack the transplanted organ. This is called rejection. Because of this, transplants usually happen between a donor and a recipient of the same blood type. This is called an identical transplant. Can I get an organ from a donor that has a different blood type than mine? Yes! If you do not have antibodies in your body against the antigens that come from the donor, your immune system should not attack the transplanted organ.
[Show full text]
Patient Information Leaflet – Plasma Exchange Procedure
Therapeutic Apheresis Services Patient Information Leaflet – Plasma Exchange Procedure Introduction Antibodies, which normally help to protect you from infection, can begin to attack your own This leaflet has been written to give patients healthy cells, or an over production of proteins can information about plasma exchange (sometimes cause your blood to become thicker and slow down called plasmapheresis). If you would like any more the blood flow throughout your body. A plasma information or have any questions, please ask the exchange can help improve your symptoms, doctors and nurses involved in your treatment at although this may not happen immediately. the NHS Blood and Transplant (NHSBT) Therapeutic Apheresis Services Unit. Although plasma exchange may help with symptoms, it will not normally cure your condition When you have considered the information given as it does not switch off the production of the in this leaflet, and after we have discussed the harmful antibodies or proteins. It is likely that procedure and its possible risks with you, we will this procedure will form only one part of your ask you to sign a consent form to indicate that you treatment. are happy for the procedure to go ahead. Before any further procedures we will again check that you are happy to proceed. How do we perform Plasma Exchange? What is a plasma exchange? Plasma exchange is performed using a machine Blood is made up of red cells, white cells and called a Blood Cell Separator which can separate platelets which are carried around in fluid called blood into its various parts. The machine separates plasma.
[Show full text]
Your Blood Cells
Page 1 of 2 Original Date The Johns Hopkins Hospital Patient Information 12/00 Oncology ReviseD/ RevieweD 6/14 Your Blood Cells Where are Blood cells are made in the bone marrow. The bone marrow blood cells is a liquid that looks like blood. It is found in several places of made? the body, such as your hips, chest bone and the middle part of your arm and leg bones. What types of • The three main types of blood cells are the red blood cells, blood cells do the white blood cells and the platelets. I have? • Red blood cells carry oxygen to all parts of the body. The normal hematocrit (or percentage of red blood cells in the blood) is 41-53%. Anemia means low red blood cells. • White blood cells fight infection. The normal white blood cell count is 4.5-11 (K/cu mm). The most important white blood cell to fight infection is the neutrophil. Forty to seventy percent (40-70%) of your white blood cells should be neutrophils. Neutropenia means your neutrophils are low, or less than 40%. • Platelets help your blood to clot and stop bleeding. The normal platelet count is 150-350 (K/cu mm). Thrombocytopenia means low platelets. How do you Your blood cells are measured by a test called the Complete measure my Blood Count (CBC) or Heme 8/Diff. You may want to keep track blood cells? of your blood counts on the back of this sheet. What When your blood counts are low, you may become anemic, get happens infections and bleed or bruise easier.
[Show full text]
Important Information for Female Platelet Donors
Important Information for Female Platelet Donors We are grateful for the support you provide our community blood program and especially appreciate your willingness to help save lives as a volunteer platelet donor. We also take our responsibility to provide a safe and adequate blood supply very seriously and need to share the following information regarding a change to our donor eligibility criteria for female platelet donors. We recently began performing a Human Leukocyte Antigen (HLA) antibody test on each of our current female platelet donors who have ever been pregnant. In addition, we modified our Medical History Questionnaire to ask donors whether they have been pregnant since their last donation. Platelet donors who respond yes to that question will be screened for HLA antibodies. Platelet donors will also be retested after every subsequent pregnancy. These adjustments are being made as part of our effort to reduce occurrences of Transfusion-Related Acute Lung Injury (TRALI). TRALI is a rare but serious complication of blood transfusions most commonly thought to be caused by a reaction to HLA antibodies present in the donor’s plasma. When transfused, these antibodies can sometimes cause plasma to leak into the patient’s lungs, creating fluid accumulation — a condition referred to as acute pulmonary edema. Female donors who have been pregnant are more likely than others to have these HLA antibodies in their plasma. Once the antibodies develop, they are present forever. The antibodies could be harmful if transfused into certain patients. The antibodies are present in plasma — and platelet donations contain a high volume of plasma, so our current efforts are directed at screening blood samples from female platelet donors to test for the HLA antibody.
[Show full text]
FACTS ABOUT DONATING Blood WHY SHOULD I DONATE BLOOD? HOW MUCH BLOOD DO I HAVE? Blood Donors Save Lives
FACTS ABOUT DONATING BLOOD WHY SHOULD I DONATE BLOOD? HOW MUCH BLOOD DO I HAVE? Blood donors save lives. Volunteer blood donors provide An adult has about 10–11 pints. 100 percent of our community’s blood supply. Almost all of us will need blood products. HOW MUCH BLOOD WILL I donate? Whole blood donors give 500 milliliters, about one pint. WHO CAN DONATE BLOOD? Generally, you are eligible to donate if you are 16 years of WHAT HAPPENS TO BLOOD AFTER I donate? age or older, weigh at least 110 pounds and are in good Your blood is tested, separated into components, then health. Donors under 18 must have written permission distributed to local hospitals and trauma centers for from a parent or guardian prior to donation. patient transfusions. DOES IT HURT TO GIVE BLOOD? WHAT ARE THE MAIN BLOOD COMPONENTS? The sensation you feel is similar to a slight pinch on the Frequently transfused components include red blood arm. The process of drawing blood should take less than cells, which replace blood loss in patients during surgery ten minutes. or trauma; platelets, which are often used to control or prevent bleeding in surgery and trauma patients; and HOW DO I PREPARE FOR A BLOOD DONATION? plasma, which helps stop bleeding and can be used to We recommend that donors be well rested, eat a healthy treat severe burns. Both red blood cells and platelets meal, drink plenty of fluids and avoid caffeine and are often used to support patients undergoing cancer alcohol prior to donating. treatments. WHAT CAN I EXPECT WHEN I DONATE? WHEN CAN I DONATE AGAIN? At every donation, you will fill out a short health history You can donate whole blood every eight weeks, platelets questionaire.
[Show full text]
FDA Regulation of Blood and Blood Components in the United States
FDA Regulation of Blood and Blood Components in the United States SLIDE 1 This presentation will review the FDA Regulation of Blood and Blood Components in the U.S. SLIDE 2 The FDA Center for Biologics Evaluation and Research, or CBER, Office of Blood Research and Review, called OBRR, reviews several different types of regulatory applications with respect to blood and blood components. This includes biologics license applications, called BLAs, which represent the regulatory pathway for blood components. The BLA regulatory process also applies to biological drugs such as fractionated plasma products. OBRR also regulates in-vitro diagnostic devices used for screening of collected blood, and does so also using the BLA regulatory pathway. Review of these devices as biologic licenses allows CBER to apply a higher level of manufacturing oversight, including lot release testing and pre-licensure inspection. This regulatory pathway applies to infectious disease tests for blood screening, as well as blood grouping and phenotyping reagents. SLIDE 3 The regulatory pathway for New Drug Applications, or NDAs, is most commonly used within the Center for Drug Evaluation and Research, or CDER. Within the Office of Blood, several NDA applications are reviewed each year, mostly involving solutions used for the collection of blood, such as anticoagulants and red cell nutritive solutions. Interestingly, a blood bag that does not have a solution inside is regulated as a device. If the bag has a solution, then it is a drug-device combination product, but is regulated as a drug. SLIDE 4 OBRR reviews both Class Two and Class Three devices. Class Three devices in OBRR include diagnostic tests for HIV regulated as pre-market approvals, called PMAs.
[Show full text]
Human ICAM-4 Antibody
Human ICAM-4 Antibody Monoclonal Mouse IgG2B Clone # 729632 Catalog Number: MAB8397 DESCRIPTION Species Reactivity Human Specificity Detects human ICAM4 in direct ELISAs. Source Monoclonal Mouse IgG2B Clone # 729632 Purification Protein A or G purified from hybridoma culture supernatant Immunogen Chinese hamster ovary cell line CHOderived recombinant human ICAM4 Ala23Ala240 Accession # Q14773 Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (SP) is supplied either lyophilized or as a 0.2 μm filtered solution in PBS. APPLICATIONS Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website. Recommended Sample Concentration Flow Cytometry 0.25 µg/106 cells See Below CyTOFready Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. DATA Flow Cytometry Detection of ICAM4 in Human Red Blood Cells by Flow Cytometry. Human red blood cells were stained with Mouse Anti Human ICAM4 Monoclonal Antibody (Catalog # MAB8397, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyaninconjugated AntiMouse IgG Secondary Antibody (Catalog # F0101B). PREPARATION AND STORAGE Reconstitution Reconstitute at 0.5 mg/mL in sterile PBS. Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at 20 to 70 °C Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw cycles.
[Show full text]
The Johns Hopkins Comprehensive Transplant Center Incompatible Kidney Transplant Programs
The Johns Hopkins Comprehensive Transplant Center Incompatible Kidney Transplant Programs The Johns Hopkins Comprehensive Transplant Center’s Incompatible Kidney Transplantation Program allows many patients previously thought to be “incompatible” to receive the gift of life. The program is comprised of several elements: Blood Type Incompatible Kidney Transplant Program Positive Crossmatch and Sensitized Patient Program Paired Kidney Exhange Program Altruistic Donor Program Blood Type Incompatible Kidney Transplant Program More than one-third of willing live donors are turned down because their blood types are not compatible with the person to whom they wish to donate their kidney. Most of us have natural antibodies against organs from people with different blood types. These antibodies can rapidly destroy a transplanted kidney. The Blood Type Incompatible Transplant Program allows patients to receive a kidney from a live donor who has an incompatible blood type (see fig1.). Patients in this program must be willing to undergo all prescribed treatments before and after the transplant to remove harmful antibodies and decrease the risk of rejection. Figure 1: Blood Type Compatibility Chart Donor Recipient How are harmful antibodies removed? Harmful antibodies are removed with a process called plasmapheresis, a procedure similar to dialysis that removes the plasma portion of the blood where antibodies are located. The number of plasmapheresis treatments required by the recipient before surgery varies depending on the amount of harmful antibodies in their blood. After each plasmapheresis the recipient receives an intravenous infusion of immune globulin to replace antibodies needed to fight infections and help prevent harmful antibodies from returning. Once the antibodies against the donor’s blood type decrease to very low levels, the transplantation can take place.
[Show full text]