Anti-ICAM4 Monoclonal Antibody (DCABH-11966) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-ICAM4 monoclonal antibody (DCABH-11966) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Immunogen A synthetic peptide of human ICAM4 is used for rabbit immunization.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Protein A

Conjugate Unconjugated

Applications Western Blot (Transfected lysate); ELISA

Size 1 ea

Buffer In 1x PBS, pH 7.4

Preservative None

Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

GENE INFORMATION

Gene Name ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) [ Homo sapiens ]

Official Symbol ICAM4

Synonyms ICAM4; intercellular adhesion molecule 4 (Landsteiner-Wiener blood group); intercellular adhesion molecule 4 (LW blood group) , intercellular adhesion molecule 4, Landsteiner Wiener blood group , Landsteiner Wiener blood group , LW; intercellular adhesion molecule 4; CD242; CD242 antigen; LW blood group protein; Landsteiner-Wiener blood group antigen a;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Entrez Gene ID 3386

Protein Refseq NP_001034221

UniProt ID Q14773

Chromosome Location 19p13.2-cen

Pathway Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Integrin cell surface interactions, organism-specific biosystem; Signal Transduction, organism-specific biosystem;

Function integrin binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]