Huwentoxin-IV

Home , Huwentoxin, Neurotoxin

Huwentoxin-IV HwTx IV- #08HWT002 Product information Animal toxins for life-sciences TTX-S selective blocker www.smartox-biotech.com Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin- Phone : +33(0) 456 520 869 sensitive (TTX-S) voltage-gated sodium channels, with an IC 50 of 30 nM in rat DRG Fax : +33(0) 456 520 868 [email protected] neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNa v 1.7 (SCN9A, IC 50 is 26 nM), rNa v 1.2 (SCN2A, IC 50 is 150 nM), and rNa v 1.3 (SCN3A, IC Smartox Biotechnology 50 is 338 nM), compared with muscle subtypes rNa v 1.4 (SCN4A) and hNa v 1.5 (SCN5A) 570 rue de la chimie (IC 50 is > 10 µM). Huwentoxin IV inhibits the activation of sodium channels by trapping 38400 Saint Martin d’Hères the voltage sensor of domain II of the site 4 in the inward, closed configuration. France

Prices

 100 µg – 110 €  500 µg – 330 €  1 mg – 500 € Technical information Related products AA sequence: Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16- 17 24 31 Cys -Lys-Ser-Ser-Lys-Leu-Val-Cys -Ser-Arg-Lys-Thr-Arg-Trp-Cys -Lys-Tyr-Gln-Ile-NH2  2 17 9 24 16 31 Hainantoxin III - #13HTX003 Disulfide bridges: Cys -Cys , Cys -Cys and Cys -Cys  Hainantoxin IV - #12HTX001 Length (aa): 35 Solubility: water and saline buffer  Huwentoxin-I - #07HWT001 Formula: C174H277N51O52S6 Source: Synthetic  GsAF-2 - # 12GSF002 Molecular Weight: 4107.20 Da Purity rate: > 97 % Appearance: White lyophilized solid References

 Minassian NA., et al.- JBC  Xiao Y., et al. - JBC  Wang RL., et al. – Jzus  Xiao Y., et al. - Mol Pharmacol  Peng K., et al. - JBC  Peigneur S., et al. - FASEB J. Toxin of the month – free sample program

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Range of blockers

Voltage-gated sodium channels Acid-sensing ion channels Voltage-gated calcium channels Chloride channels Potassium channels Nicotinic acetylcholine receptors  Voltage-gated potassium channels Purinergic receptors  Calcium activated potassium channels TRP channels  hERG channel Mechanosensitive ion channels  Inward rectifying potassium channels NMDA receptors

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