Huwentoxin-IV

Huwentoxin-IV

Huwentoxin-IV HwTx IV- #08HWT002 Product information Animal toxins for life-sciences TTX-S selective blocker www.smartox-biotech.com Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin- Phone : +33(0) 456 520 869 sensitive (TTX-S) voltage-gated sodium channels, with an IC 50 of 30 nM in rat DRG Fax : +33(0) 456 520 868 [email protected] neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNa v 1.7 (SCN9A, IC 50 is 26 nM), rNa v 1.2 (SCN2A, IC 50 is 150 nM), and rNa v 1.3 (SCN3A, IC Smartox Biotechnology 50 is 338 nM), compared with muscle subtypes rNa v 1.4 (SCN4A) and hNa v 1.5 (SCN5A) 570 rue de la chimie (IC 50 is > 10 µM). Huwentoxin IV inhibits the activation of sodium channels by trapping 38400 Saint Martin d’Hères the voltage sensor of domain II of the site 4 in the inward, closed configuration. France Prices 100 µg – 110 € 500 µg – 330 € 1 mg – 500 € Technical information Related products AA sequence: Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16- 17 24 31 Cys -Lys-Ser-Ser-Lys-Leu-Val-Cys -Ser-Arg-Lys-Thr-Arg-Trp-Cys -Lys-Tyr-Gln-Ile-NH2 2 17 9 24 16 31 Hainantoxin III - #13HTX003 Disulfide bridges: Cys -Cys , Cys -Cys and Cys -Cys Hainantoxin IV - #12HTX001 Length (aa): 35 Solubility: water and saline buffer Huwentoxin-I - #07HWT001 Formula: C174H277N51O52S6 Source: Synthetic GsAF-2 - # 12GSF002 Molecular Weight: 4107.20 Da Purity rate: > 97 % Appearance: White lyophilized solid References Minassian NA., et al.- JBC Xiao Y., et al. - JBC Wang RL., et al. – Jzus Xiao Y., et al. - Mol Pharmacol Peng K., et al. - JBC Peigneur S., et al. - FASEB J. Toxin of the month – free sample program Each month, Smartox Biotechnology offers a sample of a selected toxin for absolutely free. To be informed, visit our website each Ordering information month, subscribe our newsletter or follow us on social networks. Clic HERE Smartox products are available worldwide. To place an order, please contact us by phone or email or find out your local distributor on our website. We accept credit card payment. Range of blockers Voltage-gated sodium channels Acid-sensing ion channels Voltage-gated calcium channels Chloride channels Potassium channels Nicotinic acetylcholine receptors Voltage-gated potassium channels Purinergic receptors Calcium activated potassium channels TRP channels hERG channel Mechanosensitive ion channels Inward rectifying potassium channels NMDA receptors Follow us on All products are intended for research use only and are not intended for diagnostic or therapeutic use, not for use in humans www.smartox - biotech.com About Smartox .

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