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Supporting Information for Proteomics DOI 10.1002/Pmic.200401283

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Supporting Information for Proteomics
DOI 10.1002/pmic.200401283

Laura Bianchi, Cristina Canton, Luca Bini, Rosaria Orlandi, Sylvie Mꢀnard, Alessandro Armini, Monica Cattaneo, Vitaliano Pallini, Luigi Rossi Bernardi and Ida Biunno

Protein profile changes in the human breast cancer cell line MCF-7 in response to SEL1L gene induction

ª 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.proteomics-journal.de

Probe Set ID 38591_at 37611_at 40711_at 33540_at 1298_at
UniGene ID
397073 81791 86405 378826 510244 188553
---

  • Representative Public ID Gene Title
  • Gene Symbol

PMS2L5 TNFRSF11B YT521 C10orf18 ---

  • E+E- M+M-
  • E+M+ E-M-

  • D38501
  • postmeiotic segregation increased 2-like 5
  • D

DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDMD DDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDMD DDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
AB008822 AL049340 AL049233 X86816 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Splicing factor YT521-B Chromosome 10 open reading frame 18 Estrogen receptor cDNA, 5' splice variant retinoblastoma binding protein 6 ---
38266_at 31665_s_at 40713_at 33658_at 1465_s_at 36448_at 34777_at 32389_at 39591_s_at 40215_at 40949_at 39101_at 40942_g_at 40604_at 208_at
W25798 W27675 AB020634 S54641 S75881 X95677 D14874 W25892 Z36531 D50840 AF035812 S73840 W27026 Y13493 M94151 M55536 AB007957 L41870
RBBP6 --- NFAT5 ZNF124 MYBL1 ---
86998 421238 300592
---
441047 536594 351808 432605 369068
931 nuclear factor of activated T-cells 5, tonicity-responsive zinc finger protein 124 (HZF-16) V-myb myeloblastosis viral oncogene homolog (avian)-like 1 ---

  • adrenomedullin
  • ADM

Transcribed locus, weakly similar to XP_216369.2 similar to ORF2 consensus sequence encoding endonuclease and --- fibrinogen-like 2 UDP-glucose ceramide glucosyltransferase dynein, cytoplasmic, light intermediate polypeptide 2 myosin, heavy polypeptide 2, skeletal muscle, adult
FGL2 UGCG DNCLI2 MYH2 --- DYRK2 CTNNA2 PANK3 SNX27 RB1

  • ---
  • ---

173135 150917 388400 67619 408528 440835 212761 136965 445862
---
11355 21486 135892 259768 145894 30212 130036 142498 118630 444957 445862
--- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 catenin (cadherin-associated protein), alpha 2 Pantothenate kinase 3 sorting nexin family member 27 retinoblastoma 1 (including osteosarcoma) splicing factor 1 PI-3-kinase-related kinase SMG-1 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) RAB30, member RAS oncogene family --- thymopoietin signal transducer and activator of transcription 1, 91kDa neural cell adhesion molecule 2 adenylate cyclase 1 (brain) zinc finger, MYND domain containing 11 thyroid receptor interacting protein 15 protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform PC4 and SFRS1 interacting protein 1 MAX interactor 1 ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 RAB30, member RAS oncogene family --- --- growth factor receptor-bound protein 14 --- --- prolactin receptor ROD1 regulator of differentiation 1 (S. pombe) ---
35494_at 32503_at 1900_at 35440_g_at 32636_f_at 1935_at

  • D26121
  • SF1

AB007881 AF007111 U57092 HG961-HT961 U18271 M97935 U75330 W26466 X86098 L40388 AF070670 AF063020 D63940 U82303 U57092 AA931204 AJ005814 L76687 W28608 HG4058-HT4328 M31661
SMG1 MDM4 RAB30 --- TMPO STAT1 NCAM2 ADCY1 ZMYND11 TRIP15 PPM1A PSIP1 MXI1 ATP8A2 RAB30 --- --- GRB14 ---
807_at 305_g_at 32683_at AFFX-HUMISGF3A/M97935 38557_at 33353_at 33864_at 248_at 36435_at 37622_r_at 748_s_at 31324_at 33599_at 32911_s_at 40343_at 40683_at 41301_at 1882_g_at 1078_at 35600_at 33538_at 34717_s_at 32815_at 37681_i_at 33148_at 2033_s_at 1037_at
---
411881
---

  • ---
  • ---

212892 374634
---
3530
---
PRLR ROD1 --- FUSIP1 ---
AB023967 H96671 AF047448 AI687419 AB018266 AI459274 U10564
FUS interacting protein (serine-arginine rich) 1 --- --- zinc finger RNA binding protein WEE1 homolog (S. pombe) B melanoma antigen Paraspeckle component 1 sorting nexin 4

  • ---
  • ---

  • ZFR
  • 173518

249441
2355 16364 267812 367638
WEE1 BAGE PSPC1 SNX4 MAN1A2
U19180
32871_at 36216_at 41298_at
AL049263 AF065485

  • AF027156
  • mannosidase, alpha, class 1A, member 2

  • 262_at
  • 159118

212761
---

  • M21154
  • adenosylmethionine decarboxylase 1

PI-3-kinase-related kinase SMG-1 ---
AMD1 SMG1 ---
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
32638_s_at 1818_at 1793_at
AI610467 HG1879-HT1919 M80629 L07540 L75847 AF032119 AF070595 D86965
404501 443227 381285 460584 154336 115740 337774 519639 129541 412597
--- cell division cycle 2-like 5 (cholinesterase-related cell division controller) replication factor C (activator 1) 5, 36.5kDa zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide) calcium/calmodulin-dependent serine protein kinase (MAGUK family) Clone 24583 mRNA sequence
CDC2L5 RFC5 ZNF45 CASK
653_at 34584_at 36414_s_at 38170_at 37531_at 40100_at 40553_at 41815_at 33468_at 36235_at 37173_at 37286_at 36101_s_at 39562_at AFFX-HUMTFRR/M11507_ 31670_s_at 34112_r_at 35572_f_at 39269_at 40822_at 34878_at 36210_g_at 1773_at
---

  • TBC1 domain family, member 5
  • TBC1D5

ARHGEF2 LOC166994 SYNE2 DSG2

  • U72206
  • rho/rac guanine nucleotide exchange factor (GEF) 2

Integral membrane glycoprotein-like spectrin repeat containing, nuclear envelope 2 desmoglein 2
AI742087 AL080133 Z26317 W26334 Z15005 AB002341 M63978 AF094481 M11507

  • ---
  • ---

75573 7912 centromere protein E, 312kDa neuronal cell adhesion molecule vascular endothelial growth factor CGG triplet repeat binding protein 1 transferrin receptor (p90, CD71)
CENPE NRCAM VEGF CGGBP1 TFRC
73793 444818 185726 237825 154163
---
115474 172674 212957 75243
276

  • U81554
  • signal recognition particle 72kDa

HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae) zinc finger protein 253 replication factor C (activator 1) 3, 38kDa nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) bromodomain containing 2
SRP72 HRMT1L1 ZNF253 RFC3 NFATC3 SMC4L1 BRD2
AL050065 AF038951 L07541 L41067 AB019987 S78771

  • L00635
  • farnesyltransferase, CAAX box, beta

IL2-inducible T-cell kinase ---
FNTB ITK --- --- TAF1 --- FNBP3 KIAA0863 CDC42BPA NR4A3 DZIP3 NRIP1 RAP140 INSIG2 ZNF291 ---
1479_g_at 1164_at
211576
--- ---
1179
---
298735 131915 18586 279522 409210 155017 476396
7089
L10717 HG3344-HT3521 HG2463-HT2559 X07024 AA557228 AA675900 AB020670 U59305 D85242 AB014575 X84373 AB029028 AL080184 AA160056 HG4036-HT4306 S66427 M95712 D49354 M21154 X78925 AF001549 U44754 AF006513 M81883 U81005 W26634
960_g_at 112_g_at 34963_at 37507_i_at 37837_at 39962_at 40660_at 32131_at 40088_at 33457_at 35833_at 40937_at 1937_at
--- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa --- formin binding protein 3 KIAA0863 protein CDC42 binding protein kinase alpha (DMPK-like) nuclear receptor subfamily 4, group A, member 3 zinc finger DAZ interacting protein 3 nuclear receptor interacting protein 1 retinoblastoma-associated protein 140 insulin induced gene 2
285848
--- zinc finger protein 291 ---
1784_s_at 1654_at
19110 162967 503095 159118 145498 498879 179312 311553 420036 277132
---
AT rich interactive domain 4A (RBP1-like) v-raf murine sarcoma viral oncogene homolog B1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 adenosylmethionine decarboxylase 1 zinc finger protein 267 similar to RNA polymerase I transcription factor RRN3 small nuclear RNA activating complex, polypeptide 1, 43kDa chromodomain helicase DNA binding protein 1 glutamate decarboxylase 1 (brain, 67kDa) plakophilin 4
ARID4A BRAF
944_s_at 263_g_at 34544_at 34967_at 35488_at 39231_at 37183_at 39788_at 40487_at 39810_at 40166_at 40252_g_at 32571_at
PPFIA1 AMD1 ZNF267 LOC94431 SNAPC1 CHD1 GAD1 PKP4

  • ---
  • ---

369785
---
511765 77502
AC005253 AA923149 U00943 hypothetical protein MGC2749 --- HIV-1 rev binding protein 2 methionine adenosyltransferase II, alpha
MGC2749 --- HRB2

  • X68836
  • MAT2A

1753_s_at 1565_s_at 1013_at
440960 411366 167700 518435
---
AD000092 M96995 U59913

  • RAD23 homolog A (S. cerevisiae)
  • RAD23A

GRB2 SMAD5 STX6
DDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC growth factor receptor-bound protein 2 SMAD, mothers against DPP homolog 5 (Drosophila)

  • syntaxin 6
  • 33079_at

33669_at 34175_r_at 35603_at 34472_at 38908_s_at 39267_at 34234_f_at 35812_at 40962_s_at 1943_at
AJ002078

  • M69296
  • ---
  • ---

368302
---
AL049242 AL050030 AB012911 AL096744 AF102265 AI688640 AJ133769 D26155 X51688 U03911 L20321 L04282
Similar to KIAA0393 protein --- frizzled homolog 6 (Drosophila) REV3-like, catalytic subunit of DNA polymerase zeta (yeast) phosphoglucomutase 3 natural killer-tumor recognition sequence transportin 3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 cyclin A2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) NIMA (never in mitosis gene a)-related kinase 4 zinc finger protein 148 (pHZ-52) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 glyceraldehyde-3-phosphate dehydrogenase tubby like protein 3 farnesyltransferase, CAAX box, beta TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa SH3 and multiple ankyrin repeat domains 2 cryptochrome 1 (photolyase-like) FAT tumor suppressor homolog 2 (Drosophila) retinitis pigmentosa 2 (X-linked recessive) hypothetical protein LOC286148 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) BTB and CNC homology 1, basic leucine zipper transcription factor 1 hypothetical protein MGC8902 /// AG1 /// chomosome one amplified sequence 1 cyclophilin /// AE01 mRNA /// hypotheMGC8902 /// LOC376745 // D immunoglobulin superfamily, member 4 SH2 domain binding protein 1 (tetratricopeptide repeat containing) synaptosomal-associated protein, 23kDa 4-aminobutyrate aminotransferase seryl-tRNA synthetase CDNA FLJ13267 fis, clone OVARC1000964 high-mobility group box 2 membrane component, chromosome 11, surface marker 1 putative dimethyladenosine transferase SMAD, mothers against DPP homolog 3 (Drosophila) v-fos FBJ murine osteosarcoma viral oncogene homolog protein kinase C, iota Janus kinase 1 (a protein tyrosine kinase) histone 1, H2bf mitogen-activated protein kinase kinase kinase 1 slingshot homolog 1 (Drosophila) angiogenic factor VG5Q TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa cytokine receptor-like factor 3 KIAA0073 protein nuclear receptor subfamily 1, group D, member 2 WEE1 homolog (S. pombe)
MGC57820 --- FZD6 REV3L PGM3 NKTR TNPO3 SMARCA2 CCNA2 MSH2
276005 232021 237323 369815 412527 396404 85137 440394 433008 442787 172674 169476 437046
276
122752 12696 151573 132158 44766 165539 357318 154276 488862 156682 173288 202308
1588
444261 57079 434953 278672 113319 288261 25647 496511 309244
---
170610 60377 284216
1179
370168
1191
861_g_at 665_at 274_at
NEK4 ZNF148 NFATC3 GAPD TULP3 FNTB TAF2 SHANK2 CRY1 FAT2 RP2 LOC286148 FUT8 BACH1

  • 250_at
  • L41067

  • M33197
  • AFFX-HUMGAPDH/M33197

31944_at 37488_at 37770_at 37806_at 38148_at 38202_at 39964_at 40353_at 41628_at 31895_at 34279_at 37929_at 40844_at 32178_r_at 33446_at 34849_at 35310_at 38065_at 39471_at 39883_at 1950_s_at 1915_s_at 1603_g_at 1457_at 31522_f_at 33009_at 34082_at 35067_at 37491_at 37509_at 41638_at 35706_at 36909_at 38690_at 40513_at 40792_s_at 40845_at 33817_at
AI028290 L00635 AF026445 AB028945 D83702 AB011535 AJ007590 AL049962 Y17979 AB002803 AL050141 AB017563 D63875
IGSF4 SH2BP1 SNAP23 ABAT SARS --- HMGB2 M11S1 HSA9761 SMAD3 FOS PRKCI JAK1 HIST1H2BF MAP3K1 SSH1
DDDDDDDDDDDDDDDDDDDDDDDDDDD
AJ011915 W26407 X91257 D45288 X62534 Z48042 AF091078 AB004922 V01512 L33881 M64174 Z80779 AF042838 W28356 AI925946 D90359 AF046059 D38552 N32859 X62048 AL080097 M30773 AF091395 U10324
VG5Q TAF1 CRLF3 KIAA0073 NR1D2 WEE1 C3orf4 PPP3R1 TRIO
37288 249441 107393 280604 367689 256583 446430 chromosome 3 open reading frame 4 protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) triple functional domain (PTPRF interacting) interleukin enhancer binding factor 3, 90kDa heterogeneous nuclear ribonucleoprotein A3
ILF3

  • HNRPA3
  • S63912

33852_at 34782_at 34855_at 41598_at 33125_at 1912_s_at 1859_s_at 1544_at
391858 40154 201085
---
M77142 AL021938 X76770 AA890010 AL043470 M74088 U33203
TIA1 cytotoxic granule-associated RNA binding protein Jumonji, AT rich interactive domain 2 poly(A) polymerase alpha

  • TIA1
  • D

DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
JARID2 PAPOLA --- FANCL APC
---
534525 75081 369849 383913 258855 75862 88556 480754 37054 279806 410773
---
Fanconi anemia, complementation group L adenomatosis polyposis coli Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) Bloom syndrome
MDM2

  • BLM
  • U39817

  • 1124_at
  • L04731

U44378 U50079 AB026891 U14187 AF015812 Z98744 AB000359 L27586 AB007861 U94319 Y14153 AI191826 U71598 X51688 Z30093 AF048731 Z75331 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) SMAD, mothers against DPP homolog 4 (Drosophila) histone deacetylase 1 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 ephrin-A3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 histone 1, H2bn --- nuclear receptor subfamily 2, group C, member 2 hypothetical protein MGC22014 PC4 and SFRS1 interacting protein 1 beta-transducin repeat containing beta-transducin repeat containing zinc finger protein 274
MLL
510_g_at 476_s_at 34131_at 34573_at 34647_at 36347_f_at 36696_at 36714_at 38559_at 39243_s_at 39304_g_at 39305_at 40691_at 40697_at 40754_at 32053_at 34709_r_at 34760_at 35988_i_at 39343_at 39419_at 40442_f_at 32208_at 32255_i_at 33367_s_at 33865_at 35747_at 37359_at 37729_at 38078_at 38401_s_at 38792_at 41573_at 1928_s_at 1533_at
SMAD4 HDAC1 SLC7A11 EFNA3 DDX5 HIST1H2BN --- NR2C2 MGC22014 PSIP1
378877 447988 142498 226434 226434 83761 85137 30724 292754
8217
BTRC BTRC ZNF274 CCNA2 GTF2H3 CCNT2 STAG2 DCL-1 MYST1 TRA2A SPAG9 --- KIAA0355 TERF1 OAZIN ZMYND11 SDFR1 KIAA0102 XPO1 cyclin A2 general transcription factor IIH, polypeptide 3, 34kDa cyclin T2 stromal antigen 2 type I transmembrane C-type lectin receptor DCL-1 MYST histone acetyltransferase 1 Transformer-2 alpha sperm associated antigen 9 --- KIAA0355 telomeric repeat binding factor (NIMA-interacting) 1 ornithine decarboxylase antizyme inhibitor zinc finger, MYND domain containing 11 stromal cell derived factor receptor 1 KIAA0102 gene product exportin 1 (CRM1 homolog, yeast) filamin B, beta (actin binding protein 278) chromosome 19 open reading frame 13 spermine synthase

  • 2441
  • D14664

42343 445652 500367
---
436976 442707 223014 145894 389371 87095 157367 81008 8258
449032 154295 12253 41587 34012 79058 476302 439643 164284 410692 163484 125244 108646
---
AI417075 AW026656 AB011088 W26019 AB002353 U40705 D88674 AI926555 AF035287 D14658 Y08614 AF042166 W27594 AD001528 X68560 U78733 U63139
FLNB C19orf13 SMS

  • Sp3 transcription factor
  • SP3

SMAD, mothers against DPP homolog 2 (Drosophila) RAD50 homolog (S. cerevisiae) breast cancer 2, early onset suppressor of Ty 4 homolog 1 (S. cerevisiae) heterogeneous nuclear ribonucleoprotein C (C1/C2) solute carrier family 16 (monocarboxylic acid transporters), member 7 zinc finger protein 101 period homolog 2 (Drosophila) forkhead box A1 RAD51-like 3 (S. cerevisiae) glycerol-3-phosphate dehydrogenase 2 (mitochondrial) ---
SMAD2 RAD50 BRCA2 SUPT4H1 HNRPC SLC16A7 ZNF101 PER2
1503_at 508_at
X95152 U43923
33666_at 35547_at 36403_s_at 35008_at 37141_at 37793_r_at 41021_s_at 41625_at 31823_at 36921_at 37178_at
M16342 AF058056 AI434146 AB002345 U39840 AF034956 U36310 AB011165 M74099 U02556
FOXA1 RAD51L3 GPD2 ---
438974 446392 75639 cut-like 1, CCAAT displacement protein (Drosophila) t-complex-associated-testis-expressed 1-like hypothetical protein BC017169
CUTL1 TCTE1L

  • LOC91137
  • M74089

37640_at 38984_at 39046_at 39742_at 40089_at 40441_g_at 36669_at 37747_at 38440_s_at 32517_at 33151_s_at 2037_s_at 1635_at
412707 535763 301005 123294 413036 356427 75678 145741 83530 7145
M31642 AB007896 AL049324 U59863 AJ224442 AL080119 L49169 hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) putative prolyl oligopeptidase H2A histone family, member V TRAF family member-associated NFKB activator Williams Beuren syndrome chromosome region 22 PAI-1 mRNA-binding protein FBJ murine osteosarcoma viral oncogene homolog B annexin A5 armadillo repeat containing, X-linked 6 calpain 7 --- ribosomal protein S6 kinase, 70kDa, polypeptide 1 v-abl Abelson murine leukemia viral oncogene homolog 1 CDC-like kinase 2
HPRT1 KIAA0436 H2AFV TANK WBSCR22 PAI-RBP1 FOSB ANXA5 ARMCX6 CAPN7 --- RPS6KB1 ABL1
DDDDDDDDDDDDDDDMD DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
DDDDDDDDDDDDDDDMD DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
U05770 AA015605 AB028639 W25932 M60725 U07563
---
86858 446504

  • 73986
  • 646_s_at

350_at
L29218 D28118 AB007860 Z48950 AI095013 AI688098 AI688098 AJ002572 X16281 AI949914 L20826 Y15227
CLK2
414455 200666 180877 134999 356901 425808 435904 24120 380964 203637 344524 306307 293044 28285 371974 426324 22315 108371 12259 179881 414993 443518 270804
---
144130 288178 73965 zinc finger protein 161 development and differentiation enhancing factor 2 H3 histone, family 3B (H3.3B) histone 1, H2am histone 1, H2bc calmodulin 2 (phosphorylase kinase, delta) chromosome 21 open reading frame 107 zinc finger protein 44 (KOX 7) POM121 membrane glycoprotein (rat) /// postmeiotic segregation increased 2-like 3 plastin 1 (I isoform) deleted in lymphocytic leukemia, 1 Rho-associated, coiled-coil containing protein kinase 1 MRNA; cDNA DKFZp586K1123 (from clone DKFZp586K1123) ring finger protein 139
ZNF161 DDEF2 H3F3B HIST1H2AM HIST1H2BC CALM2 C21orf107 ZNF44 POM121 /// PMS2L3 PLS1 DLEU1 ROCK1 --- RNF139 ACVR1B TUSC3 CREB1 E2F4 HIPK1 CBFB C6orf111 DST CREBBP --- FLJ10618 SSA2 SFRS2 TBCC ILF2 ARF4 NDUFA5 TRIO HAN11 DARS ERBB3 CCNG2 DNASE2 ATRX ELF2 GAPD GAPDS CTSB ZNF148
39410_at 31510_s_at 33023_at 32980_f_at 33458_r_at 34994_at 35408_i_at 35858_at 39951_at 33791_at 34735_at 35187_at 35212_at 36451_at 36852_at 37535_at 38707_r_at 39376_at 41175_at 41784_at 32780_at 33831_at 34803_at 34804_at 35295_g_at 36112_r_at 36176_at 36189_at 36585_at 38462_at 40581_at 41591_at 32615_at 2089_s_at 1913_at
U43195 AL080216 AF064801 AI743299 U42349 M27691 S75174 AB014530 L20298 AL080186 AB018271 U47741 AF022789 AL049246 M25077 X75755 U61234 U10323 M36341 U64028 U42390 AI652978 J05032 H06628 U47414 AD000092 U72936 activin A receptor, type IB tumor suppressor candidate 3 cAMP responsive element binding protein 1 E2F transcription factor 4, p107/p130-binding homeodomain interacting protein kinase 1 core-binding factor, beta subunit chromosome 6 open reading frame 111 dystonin CREB binding protein (Rubinstein-Taybi syndrome) --- Hypothetical protein FLJ10618 Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro) splicing factor, arginine/serine-rich 2 tubulin-specific chaperone c interleukin enhancer binding factor 2, 45kDa ADP-ribosylation factor 4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa triple functional domain (PTPRF interacting) WD-repeat protein
75064 75117 435639 83916 367689 410596 32393 306251 13291 118243 440734 82143 aspartyl-tRNA synthetase v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) cyclin G2

  • 1747_at
  • deoxyribonuclease II, lysosomal

818_s_at 507_s_at AFFX-HUMGAPDH/M33197 34542_at 32372_at 41466_s_at alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) E74-like factor 2 (ets domain transcription factor) glyceraldehyde-3-phosphate dehydrogenase glyceraldehyde-3-phosphate dehydrogenase, spermatogenic cathepsin B
U43189
169476 248017 135226 442787
M33197 AJ005371 L22569

  • L04282
  • zinc finger protein 148 (pHZ-52)

41665_at 33219_at 33221_at 36841_at 36845_at 38688_at 39730_at 40492_at 40803_at 41170_at 32841_at 33340_at 38102_at 41346_at 41795_at 32597_at 1789_at
123654 173694 443881 444776 421150 107088 446504 446102 172089
---
AB020631 AB029020 U80735 AA811338 D50926 AB007930 X16416 AB020633 AL050161 AB014563 U19765 AB007898 W28575 AJ007583 X17576 S67171 U65928 pre-mRNA cleavage complex II protein Pcf11 ubiquitin specific protease 33 PAX transcription activation domain interacting protein 1 like peroxisomal acyl-CoA thioesterase zinc finger, CW-type with coiled-coil domain 3 pogo transposable element with ZNF domain v-abl Abelson murine leukemia viral oncogene homolog 1 KIAA0826 protein pro-oncosis receptor inducing membrane injury gene --- zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) praja 2, RING-H2 motif containing EF hand domain family A1 like-glycosyltransferase NCK adaptor protein 1
PCF11 USP33 PAXIP1L PTE1 ZCWCC3 POGZ
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDI
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDI
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
ABL1 KIAA0826 PORIMIN --- ZNF9 PJA2 EFHA1 LARGE NCK1 RBL2 COPS5 TPR
2110
224262 412103 25220 54589 283604 446492 170472 183704 76888 retinoblastoma-like 2 (p130) COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) translocated promoter region (to activated MET oncogene) ubiquitin C

  • 421_at
  • X66397

32334_f_at 37210_at 37891_at 39727_at 33847_s_at 34394_at 35746_r_at 39147_g_at 39879_s_at 41243_at 1798_at
AB009010 S78296 U79272 AF023917 U10906 AB018327 X78136
UBC

  • INA
  • internexin neuronal intermediate filament protein, alpha

hypothetical protein MGC21416 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) cyclin-dependent kinase inhibitor 1B (p27, Kip1) activity-dependent neuroprotector
82719 14611
MGC21416 DUSP11 CDKN1B ADNP PCBP2 ATRX
238990 448540 132977 440734 500300 214646 79136 258561 290346 75626 poly(rC) binding protein 2
U72936 H16917 alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) Transcribed locus, moderately similar to NP_055649.2 KIAA0563 gene product [Homo sapiens] solute carrier family 35, member E2 solute carrier family 39 (zinc transporter), member 6 general transcription factor IIB mitogen-activated protein kinase kinase kinase 7 CD58 antigen, (lymphocyte function-associated antigen 3) tousled-like kinase 1
---
AB007916 U41060 M76766 AB009356 Y00636 D50927 U61263 D87116 S87759 AC004668 U51698 AL080071 X73424 AL031178 AI991040 U52427
SLC35E2 SLC39A6 GTF2B MAP3K7 CD58
1070_at 36905_at 37177_at 32219_at 37690_at 1622_at
369280 78880
TLK1

  • ILVBL
  • ilvB (bacterial acetolactate synthase)-like

180533 130036 417004 311079 38044 mitogen-activated protein kinase kinase 3 protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform S100 calcium binding protein A11 (calgizzarin) apoptosis antagonizing transcription factor DKFZP564M082 protein propionyl Coenzyme A carboxylase, beta polypeptide F-box protein 9 DR1-associated protein 1 (negative cofactor 2 alpha) polymerase (RNA) II (DNA directed) polypeptide G isocitrate dehydrogenase 3 (NAD+) beta
MAP2K3 PPM1A S100A11 AATF DKFZP564M082 PCCB FBXO9 DRAP1 POLR2G IDH3B ATP5J2 NDUFB8 MAEA APRT ATP5G3 SDHA GOLGA3 SOD1 ZYX

  • I
  • I

  • 857_at
  • I
  • I

38138_at 32117_at 35715_at 36561_at 38990_at 39076_s_at 39747_at 40111_g_at 40134_at 32774_at 32832_at 34310_at 34811_at 34826_at 34861_at 36620_at 36958_at 37320_at 37666_at 38055_at 38744_at

  • I
  • I

  • I
  • I

  • I
  • I

  • 63788
  • I
  • I

388387 356742 14839 436405 235557 198273 253067 28914
429
440475
4953
443914 75873 77329

  • I
  • I

  • I
  • I

  • I
  • I

  • U49283
  • I
  • I

AF047436 AI541050 AF084928 Y00486 U09813 L21936 D63997 X02317 X95735 D14694
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa macrophage erythroblast attacher

  • I
  • I

  • I
  • I

  • I
  • I

  • adenine phosphoribosyltransferase
  • I
  • I

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) golgi autoantigen, golgin subfamily a, 3 superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) zyxin

  • I
  • I

  • I
  • I

  • I
  • I

  • I
  • I

  • I
  • I

  • phosphatidylserine synthase 1
  • PTDSS1

PSMB5 POLR2J SHFM1

  • I
  • I

422990 533383 333495
D29011 AI683748 N95406 proteasome (prosome, macropain) subunit, beta type, 5 polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa split hand/foot malformation (ectrodactyly) type 1

  • I
  • I

  • I
  • I

  • I
  • I

39867_at 40593_at 40906_at 41590_at 1718_at
12084 172550 301463
5008
S75463 X66975 AC002310 AI652660 U50523 L76200
Tu translation elongation factor, mitochondrial polypyrimidine tract binding protein 1 similar to hypothetical protein MGC13138 tetratricopeptide repeat domain 15 actin related protein 2/3 complex, subunit 2, 34kDa guanylate kinase 1

  • TUFM
  • I

IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
PTBP1 LOC146542 TTC15 ARPC2 GUK1
83583

  • 905_at
  • 376933

446394 512670
142
322852 16081 434243 352687 102548 423854 37003
754_s_at 41111_at 31804_f_at 31874_at 32111_at 34213_at 34260_at 34724_at 35646_at 35701_at 36027_at 36529_at 36880_at 37617_at 37998_at 38610_s_at 38981_at 39357_at 39729_at 40787_at 40872_at 41162_at 41223_at 41724_at 32858_at 33361_at 34315_at 34332_at 34369_at 34406_at 34893_at 35297_at 36676_at 36952_at 36960_at 38056_at 38069_at 38080_at 38416_at 39822_s_at 40210_at 32543_at 32575_at 33135_at 1590_s_at 1551_g_at 1351_at
D87002 U68418 X78283

  • breakpoint cluster region
  • BCR

branched chain aminotransferase 2, mitochondrial sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 growth arrest-specific 2 like 1 chromodomain protein, Y-like KIBRA protein KIAA0683 gene product glucocorticoid receptor DNA binding factor 1 surfeit 1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog polymerase (RNA) II (DNA directed) polypeptide F hypothetical protein MGC2650 NAD(P)H dehydrogenase, quinone 2 KIAA1128 superkiller viralicidic activity 2-like (S. cerevisiae) keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa C2f protein peroxiredoxin 2 WIRE protein cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous) protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform cytochrome c oxidase subunit Va B-cell receptor-associated protein 31 ubinuclein 1 Bernardinelli-Seip congenital lipodystrophy 2 (seipin) AFG3 ATPase family gene 3-like 2 (yeast) glucosamine-6-phosphate deaminase 1 mitofusin 2
BCAT2 SULT1A1 GAS2L1 CDYL
Y07846 AL050164 AB020676 AB014583 AI670100 Z35093 AI038821 AA418779 AI885381 U07736 U90912 U09877 X14487 AA203354 U72514 L19185 U90911 T57872 Y13936 M22760 X81109 AI341565 AF052149 Y18314 D31766 D86987 AB011174 AI557064 AC002400 AL031659 D16480 U89278 D83779 Z67743
KIBRA KIAA0683 GRLF1 SURF1 HRAS POLR2F MGC2650 NQO2 KIAA1128 SKIV2L KRT10 NDUFB3 C2F
46405 386422 441039 81897 89864 99936 109760 135643 432121 421622 431668 17883 401903 381232 21479 438912 436683 278500 376681 436281 51299 5556
406532 75860 165263 301132 80768 433901 82916
PRDX2 WIRE COX6B1 PPM1G COX5A BCAP31 UBN1 BSCL2 AFG3L2 GNPDA1 MFN2 KIAA0602 NDUFV2 NDUFAB1 RPN2
KIAA0602 protein NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa ribophorin II hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctiona HADHA

  • polyhomeotic-like 2 (Drosophila)
  • PHC2

KIAA0195 gene product chloride channel 7
KIAA0195 CLCN7 COX8A CCT6A GADD45B RAB13 CALR NAP1L4 SLC19A1 HRAS MRPL28 EPHB4 PSMB3 ITGA3 NME3 NDUFB1
AI525665 L27706 AF078077 X75593 cytochrome c oxidase subunit 8A (ubiquitous) chaperonin containing TCP1, subunit 6A (zeta 1) Growth arrest and DNA-damage-inducible, beta RAB13, member RAS oncogene family calreticulin nucleosome assembly protein 1-like 4 solute carrier family 19 (folate transporter), member 1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog mitochondrial ribosomal protein L28
110571 151536 433673 269403 84190
M84739 U77456 U17566 J00277 U19796 U07695 D26598 M59911 U29656 AI345944
37003 279869 437008 82793
EPH receptor B4

  • 1309_at
  • proteasome (prosome, macropain) subunit, beta type, 3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) non-metastatic cells 3, protein expressed in NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
885_g_at 198_g_at 38605_at
265829 81687 183435
31836_at 36035_at 37230_at 37240_at 37912_at 39003_at 39022_at 39722_at 39770_at 40052_at 40414_at 40521_at 41732_at 32816_at 33854_at 34345_at 34792_at 34865_at 35756_at 35835_at 35836_at 36127_g_at 36169_at 36973_at 37300_at 37311_at 38750_at 39113_at 39169_at 39184_at 41288_at 41316_s_at 32528_at 32595_at 33121_g_at 33154_at 33215_g_at 1311_at
149894
4742 7764
432560
8375

  • L34600
  • mitochondrial translational initiation factor 2

GPAA1P anchor attachment protein 1 homolog (yeast) KIAA0469 gene product histidyl-tRNA synthetase-like TNF receptor-associated factor 4 pituitary tumor-transforming 1 interacting protein DKFZP586J0619 protein hypothetical protein LOC149603 chromosome 1 open reading frame 16 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) valyl-tRNA synthetase 2
MTIF2 GPAA1 KIAA0469 HARSL TRAF4 PTTG1IP DKFZP586J0619 LOC149603 C1orf16 ACTR1A VARS2 RGL2 LAT1-3TM SGTA ATP6V1D C20orf14 AHCYL1 NDUFS6 RGS19IP1 ANAPC5 NUDC COASY NDUFA1 SF3B2 DNCH1 TALDO1 NOTCH3 ERP70 SEC61G TCEB2
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
AB002135 AL031447 U18937 X80200 Z50022 AL050110 AF044209 D87437 X82206 X59303 AL050259 AA310786 AL050156 AA877795 AF026031 AL049954 AI360249 AF089816 AB019409 AB019408 U18919
369026 112184 356377 43660 153961 159637 170160 449815 203910 272630 31334 4113
408257 396978
7101
263812 296422 74823 406423
7720 ral guanine nucleotide dissociation stimulator-like 2 LAT1-3TM protein small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D chromosome 20 open reading frame 14 S-adenosylhomocysteine hydrolase-like 1 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) regulator of G-protein signalling 19 interacting protein 1 anaphase promoting complex subunit 5 nuclear distribution gene C homolog (A. nidulans) Coenzyme A synthase NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa Splicing factor 3b, subunit 2, 145kDa dynein, cytoplasmic, heavy polypeptide 1 transaldolase 1 Notch homolog 3 (Drosophila) protein disulfide isomerase related protein (calcium-binding protein, intestinal-related) Sec61 gamma subunit transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) calmodulin 1 (phosphorylase kinase, delta) scaffold attachment factor B ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) G-rich RNA sequence binding factor 1
N47307 U41371 AB002323 AF010400 U97669 AI262789 AF054184 AI857469 AL036744 U72355 Z50853 U07231 AF045229 D26600 Y11681
438678
8546 93659 9950
172772 282410 23978 317335 309763 82280 89545 411125 89545 75307 170560 15114 344400 433291 22616 3618
CALM1 SAFB CLPP GRSF1 RGS10 PSMB4 MRPS12 PSMB4 H1FX regulator of G-protein signalling 10 proteasome (prosome, macropain) subunit, beta type, 4 mitochondrial ribosomal protein S12 proteasome (prosome, macropain) subunit, beta type, 4 H1 histone family, member X
D26600

  • 318_at
  • D64142

38954_at 31846_at 31864_at 31873_at 34259_at 35693_at 37211_at 37992_s_at 38640_at 38652_at 38967_at 39001_at 39004_at 39443_s_at 39712_at 39719_at 40076_at 40112_at
Y18423 AW003733 X98263 vasoactive intestinal peptide receptor 2 ras homolog gene family, member D M-phase phosphoprotein 6 ARD1 homolog, N-acetyltransferase (S. cerevisiae) KIAA0664 protein hippocalcin-like 1 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit zinc finger protein 593 chromosome 10 open reading frame 26 chromosome 14 open reading frame 2 malate dehydrogenase 2, NAD (mitochondrial) mitochondrial ribosomal protein S11 cytochrome c oxidase subunit Vb
VIPR2 RHOD MPHOSPH6 ARD1 KIAA0664 HPCAL1 BDH
U52112 AB014564 AF070616 M93107 AI436567 AI582831 AF070644 AF054175 AF047470 AI432190 M19961
434560 501304 102419 10346 109052 405860 111286
1342
446592 296380 154718 436405
ATP5D ZNF593 C10orf26 C14orf2 MDH2 MRPS11 COX5B S100A13 POMZP3 TPD52L2 IDH3B
AI541308 X56777 AF004430 AA522698
S100 calcium binding protein A13 POM (POM121 homolog, rat) and ZP3 fusion tumor protein D52-like 2 isocitrate dehydrogenase 3 (NAD+) beta
40862_i_at 32181_at 32211_at 32761_at 33889_s_at 34400_at 34405_at 34864_at 36136_at 37760_at 38060_at 38419_at 38483_at 38751_i_at 39837_s_at 39921_at 41807_at 33133_at 1680_at
173724 18799
X15334 M60922 creatine kinase, brain flotillin 2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 serine/arginine repetitive matrix 2 DiGeorge syndrome critical region gene 2 low molecular mass ubiquinone-binding protein (9.5kD) ubiquitin specific protease 5 (isopeptidase T) chromosome 2 open reading frame 24 tumor protein p53 inducible protein 11 BAI1-associated protein 2 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) KIAA0196 gene product dullard homolog (Xenopus laevis)

  • CKB
  • I

IIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
IIIIIIIIIIIIIIIIIIIIIMI IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
FLOT2 PSMD13 SRRM2 DGCR2 QP-C
279554 433343 415359 146602
3759
AB009398 AB002322 D79985 AI540957 U47927 AF070638 AF010315 AB015019 AI541336 D83780 AJ011916 AA426364 AC004877 AI526089 AL040137 U80184
USP5

  • 4973
  • C2orf24

TP53I11 BAIAP2 NDUFS5 KIAA0196 DULLARD ATP5I EZI COX5B ---
433813 128316 409829 437991 84359 85539 112158
1342
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e likely ortholog of mouse zinc finger protein EZI cytochrome c oxidase subunit Vb Transcribed locus, weakly similar to XP_316923.1 Anopheles gambiae str. PEST ENSANGG00000020250 gene flightless I homolog (Drosophila)
531457 445182 86859
FLII

  • GRB7
  • D43772
  • growth factor receptor-bound protein 7

  • cell division cycle 34
  • 1274_s_at

556_s_at 537_f_at
423615 279837 446394 241305 317095 406998 433445 184510 386278 90443 236361 415067 287994 12124 323363 174071 183800 25723 194673 356181
5300 5300 57729 296422 75353 77667
L22005 M96233 U07000 AF096870 J05272 U92315 Y14330 X57348 AJ005866 AF038406 X75314 D44497 U37146 AA522537 U06863 U31525 X82260 AF052151 X86809
CDC34 GSTM2 /// GSTM1 /// GSTMI BCR TRIM16 IMPDH1 SULT2B1 JAG2 glutathione S-transferase M2 (muscle) /// glutathione S-transferase M1 /// glutathione S-transferase M4 breakpoint cluster region tripartite motif-containing 16 IMP (inosine monophosphate) dehydrogenase 1 sulfotransferase family, cytosolic, 2B, member 1 jagged 2
MI
38882_r_at 40695_at 41034_s_at 32137_at 33322_i_at 38005_at 38257_at 38661_at 38976_at 39358_at 39367_at 40130_at 40876_at 32151_at 32209_at 32260_at 33908_at 35266_at 35267_g_at 35322_at 36126_at 36602_at 37360_at 38841_at 39162_at 40182_s_at 40546_s_at 40613_at 1641_s_at 1072_g_at 461_at
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII

  • stratifin
  • SFN

  • solute carrier family 35, member D2
  • SLC35D2

NDUFS8 RNPC1 CORO1A NCOR2 ELAC2 FLJ22169 GYG RANGAP1 MTVR1 PEA15 CAPN1 BLCAP BLCAP KEAP1 COASY PMPCA LY6E UBADC1 GTF2H5 CARM1 NDUFA2 C6orf62 DDB1 GATA2 ASAH1 ---
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) RNA-binding region (RNP1, RRM) containing 1 coronin, actin binding protein, 1A nuclear receptor co-repressor 2 elaC homolog 2 (E. coli) hypothetical protein FLJ22169 glycogenin Ran GTPase activating protein 1 Mouse Mammary Turmor Virus Receptor homolog 1 phosphoprotein enriched in astrocytes 15 calpain 1, (mu/I) large subunit bladder cancer associated protein bladder cancer associated protein
X04366 AL049288 AL049288 D50922 U18919 D21064 kelch-like ECH-associated protein 1 Coenzyme A synthase peptidase (mitochondrial processing) alpha lymphocyte antigen 6 complex, locus E ubiquitin associated domain containing 1 general transcription factor IIH, polypeptide 5 coactivator-associated arginine methyltransferase 1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa chromosome 6 open reading frame 62 damage-specific DNA binding protein 1, 127kDa GATA binding protein 2 N-acylsphingosine amidohydrolase (acid ceramidase) 1 --- isocitrate dehydrogenase 2 (NADP+), mitochondrial CGI-96 protein
U66711

  • 9194
  • AF068195

AA156987 AF055027 AF047185 AL031775 U32986 M77810 U70063 HG2259-HT2348 X69433 AL022316 AF055006
356224 371416 163867 432608 290758 367725 324808

  • ---
  • 330_s_at

32332_at 33307_at 37597_s_at
5337
534041 448580
IDH2 CGI-96

  • SEC6L1
  • SEC6-like 1 (S. cerevisiae)

39062_at 39439_at 39801_at 33392_at 35820_at 37377_i_at 1218_at
118126 133130 153357 226372 387156 436441 239752 388921 410683 106730 425633 172684 201362 73875
AL008726 AL050035 AF046889 AL080155 M76477 protective protein for beta-galactosidase (galactosialidosis) MRNA; cDNA DKFZp566H0124 (from clone DKFZp566H0124) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 WIPI49-like protein 2 GM2 ganglioside activator lamin A/C nuclear receptor subfamily 2, group F, member 6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 homer homolog 3 (Drosophila)
PPGB --- PLOD3 DKFZP434J154 GM2A
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
M13452 X12794
LMNA NR2F6 PSMD2 HOMER3 C22orf3 CKMT1 VAMP8 B3GAT3 FAH

  • 1166_at
  • D78151

38233_at 41414_at 31887_at 32715_at 35179_at 36876_at 38685_at 39043_at 40133_s_at 40470_at 33433_at 35794_at 38423_at 38451_at 39910_at 41596_s_at 37882_at 33323_r_at 33751_at 34731_at 36116_at 38043_at 1940_at
AF093265 AL050346 J04469 AF053233 AB009598 M55150 AL035306 AF006084 W28944 D10523 AL049943 AB023159 L38935 T58471 AA663800 U43573 X63468 X57348 AL109702 D80007 AJ000414 X55448 M54968 L41351 chromosome 22 open reading frame 3 creatine kinase, mitochondrial 1 (ubiquitous) vesicle-associated membrane protein 8 (endobrevin) beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) fumarylacetoacetate hydrolase (fumarylacetoacetase) syntaxin 12 actin related protein 2/3 complex, subunit 1B, 41kDa glyoxylate reductase/hydroxypyruvate reductase oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) DKFZP564F0522 protein
433838 433506 155742 168669 23060 408177 432850
8372
331308 50727 145381 184510 19720 239499 445226 289108 412107 75799 115325 343220 183109 18879
STX12 ARPC1B GRHPR OGDH DKFZP564F0522 PSD3 LOC162427 UQCR MARCH-II NAGLU GTF2E1 SFN AP3S2 PDCD11 TRIP10 FAM3A KRAS2 PRSS8 RAB7L1 CRK pleckstrin and Sec7 domain containing 3 hypothetical protein LOC162427 ubiquinol-cytochrome c reductase (6.4kD) subunit membrane-associated RING-CH protein II N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) general transcription factor IIE, polypeptide 1, alpha 56kDa stratifin Adaptor-related protein complex 3, sigma 2 subunit programmed cell death 11 thyroid hormone receptor interactor 10 family with sequence similarity 3, member A v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog protease, serine, 8 (prostasin) RAB7, member RAS oncogene family-like 1 v-crk sarcoma virus CT10 oncogene homolog (avian) monoamine oxidase A chromosome 12 open reading frame 22 neuropathy target esterase furin (paired basic amino acid cleaving enzyme) BAI1-associated protein 2 Snf2-related CBP activator protein upstream transcription factor 2, c-fos interacting solute carrier family 6 (neurotransmitter transporter, creatine), member 8 mitogen-activated protein kinase kinase kinase 5 cathepsin D (lysosomal aspartyl protease) hyperpolarization activated cyclic nucleotide-gated potassium channel 2 ladinin 1 SP110 nuclear body protein Microtubule-associated protein 1B protocadherin 9
634_at 37466_at 38219_at 41770_at 32217_at 34874_at 35338_at 37761_at 38766_at 39112_at 40926_at 1327_s_at 239_at 34520_at 33282_at 35718_at 38396_at 39878_at 32533_s_at 33241_at 37909_at 1898_at
D84488 D10656 AA420624 AF052105 AJ004832 X17094 AB015020 AB002307 Y07661 U52111 U67156 M63138 AJ012582 U42408 L22342 Y09836 AI524125 AF054825 AB014526 L34155 L24203 S76638 AJ133133 D87464 AB018267
MAOA C12orf22

  • NTE
  • 511760

  • 59242
  • FURIN

128316 445097 454534 388375 151988 121575 124161 18141
BAIAP2 SRCAP USF2 SLC6A8 MAP3K5 CTSD HCN2 LAD1 SP110 MAP1B PCDH9 VAMP5 MFAP3L LAMA3 TRIM29 NFKB2 ENTPD1 KIAA0274 ---
38125 103042 132377 534425 178121 83450 82237 73090 444105 419998
--- vesicle-associated membrane protein 5 (myobrevin) Microfibrillar-associated protein 3-like laminin, alpha 3 tripartite motif-containing 29

  • 544_at
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

ectonucleoside triphosphate diphosphohydrolase 1 KIAA0274
32826_at 41101_at

  • 32095_at
  • ---

36069_at 41294_at 38131_at 41106_at 37701_at 38125_at 32574_at 36933_at 39805_at 41096_at 37628_at 41586_at 38286_at 39016_r_at 32168_s_at 36591_at 717_at
5003 23881 146688 10082 78944 414795 77813 318567 107911 416073 82163 87191 9271
367762 282326 75318 155418 114948
408
AB007925 AJ238246 AF010316 AF022797 L13463 M14083 X59960 D87953 AF070598 AI126134 M69177 AF075292 AB028994 L42611 formin binding protein 2 keratin 7 prostaglandin E synthase
FNBP2 KRT7
IIIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
IIIIIIIIIIIIIIIIIIIIIIIIIII
NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
PTGES KCNN4 RGS2 SERPINE1 SMPD1 NDRG1 ABCB6 S100A8 MAOB FGF18 AMOT KRT6A /// KRT6C DSCR1 TUBA1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 regulator of G-protein signalling 2, 24kDa serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) N-myc downstream regulated gene 1 ATP-binding cassette, sub-family B (MDR/TAP), member 6 S100 calcium binding protein A8 (calgranulin A) monoamine oxidase B fibroblast growth factor 18 angiomotin keratin 6A /// keratin 6C Down syndrome critical region gene 1 tubulin, alpha 1 (testis specific)
U85267 X06956

  • D87119
  • tribbles homolog 2 (Drosophila)
  • TRIB2

39842_at 39939_at 33183_at 33331_at 41471_at 37319_at 36424_at 39681_at 39015_f_at 32531_at 941_at
AF059293 D21337 L76927 cytokine receptor-like factor 1 collagen, type IV, alpha 6 galactokinase 1 BENE protein S100 calcium binding protein A9 (calgranulin B) insulin-like growth factor binding protein 3 nebulette zinc finger and BTB domain containing 16 keratin 6A /// keratin 6C
CRLF1 COL4A6

  • GALK1
  • 407966

185055 112405 450230
5025
292207 367762 74471 77060

  • U17077
  • BENE

W72424 M35878 AI435834 AF060568 L42611
S100A9 IGFBP3 NEBL ZBTB16 KRT6A /// KRT6C

  • GJA1
  • X52947

D29012 gap junction protein, alpha 1, 43kDa (connexin 43)

  • proteasome (prosome, macropain) subunit, beta type, 6
  • PSMB6

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  • SUPPLEMENTARY MATERIALS and METHODS PBMC Transcriptomics

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  • Supplementary Figure S1 A

    Supplementary Figure S1 A

    Supplementary Figure S1 A B C 1 4 1 3 1 2 1 2 1 0 1 1 (Normalized signal values)] 2 (Normalized signal values) (Normalized 8 2 10 Log 6 AFFX-BioC AFFX-BioB AFFX-BioDn AFFX-CreX hDFs [Log 6 8 10 12 14 hOFs [Log2 (Normalized signal values)] Supplementary Figure S2 GLYCOLYSIS PENTOSE-PHOSPHATE PATHWAY Glucose Purine/pyrimidine Glucose-6-phosphate metabolism AMINO ACID Fluctose-6-phosphate AMPK METABOLISM TIGAR PFKFB2 methylgloxal GloI Ser, Gly, Thr Glyceraldehyde-3-phosphate ALDH Lactate PYRUVATE LDH METABOLISM acetic acid Ethanol Pyruvate GLYCOSPHINGOLIPID NADH BIOSYNTHESIS Ala, Cys DLD PDH PDK3 DLAT Fatty acid Lys, Trp, Leu, Acetyl CoA ACAT2 Ile, Tyr, Phe β-OXIDATION ACACA Citrate Asp, Asn Citrate Acetyl CoA Oxaloacetate Isocitrate MDH1 IDH1 Glu, Gln, His, ME2 TCA Pro, Arg 2-Oxoglutarate MDH1 CYCLE Pyruvate Malate ME2 GLUTAMINOLYSIS FH Succinyl-CoA Fumalate SUCLA2 Tyr, Phe Var, Ile, Met Supplementary Figure S3 Entrez Gene Symbol Gene Name hODs hDFs hOF-iPSCs GeneID 644 BLVRA biliverdin reductase A 223.9 259.3 253.0 3162 HMOX1 heme oxygenase 1 1474.2 2698.0 452.3 9365 KL klotho 54.1 44.8 36.5 nicotinamide 10135 NAMPT 827.7 626.2 2999.8 phosphoribosyltransferase nuclear factor (erythroid- 4780 NFE2L2 2134.5 1331.7 1006.2 derived 2) related factor 2 peroxisome proliferator- 5467 PPARD 1534.6 1352.9 330.8 activated receptor delta peroxisome proliferator- 5468 PPARG 524.4 100.8 63.0 activated receptor gamma 5621 PRNP prion protein 4059.0 3134.1 1065.5 5925 RB1 retinoblastoma 1 882.9 805.8 739.3 23411 SIRT1 sirtuin 1 231.5 216.8 1676.0 7157 TP53
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