Research Article • DOI: 10.2478/s13380-013-0113-6 • Translational Neuroscience • 4(2) • 2013 • 172-202 Translational Neuroscience

TRANSPOSABLE ELEMENTS OCCUR MORE FREQUENTLY IN AUTISM RISK : Emily L. Williams1*, Manuel F. Casanova2, Andrew E. Switala2, IMPLICATIONS FOR THE ROLE OF Hong Li1, Mengsheng Qiu1 GENOMIC INSTABILITY IN AUTISM

1Department of Anatomical Sciences Abstract and Neurobiology, University of Louisville An extremely large number of genes have been associated with autism. The functions of these genes span School of Medicine, Louisville, Kentucky, USA numerous domains and prove challenging in the search for commonalities underlying the conditions. In this study, we instead looked at characteristics of the genes themselves, specifically in the nature of their transposable element content. Utilizing available sequence databases, we compared occurrence of transposons in autism- 2Department of Psychiatry and Behavioral risk genes to randomized controls and found that transposable content was significantly greater in our autism Sciences, University of Louisville School group. These results suggest a relationship between transposable element content and autism-risk genes and of Medicine, Louisville, Kentucky, USA have implications for the stability of those genomic regions.

Keywords Received 05 April 2013 • Autism-risk genes • Autism spectrum disorders • Genomic instability • Transposons. accepted 03 May 2013 © Versita Sp. z o.o.

1. Introduction associated with autism [3]. Pinto et al. in their X syndrome and its CGG-trinucleotide repeats, extensive study of copy number variants (CNV) or environmentally induced as shown in a Transposable elements (TE) are segments of in the condition found that on average CNVs number of cancers [6,7]. In addition, some DNA within genomes capable of mobility, tended to occur in and around genes belonging instances of CNV show a strong relationship exhibiting either a copy-and-paste method to one of three functional domains: 1) cell with their resident TE, such as the Drosophila in which an RNA intermediate is transcribed proliferation, 2) cell motility, and 3) GTPase/ melanogaster Cyp6g1 , the culprit for some into DNA and reinserted elsewhere within Ras signaling [4]. While these findings aid in fruit flies’ adapted resistance to DDT [8]. the genome, or a cut-and-paste method in understanding how these genes factor into the As discussed, the genome contains which a DNA segment excises and reinserts etiology of autism, it doesn’t answer why such a close to 50% TE content but the majority of itself. These mobile elements comprise vast range of genes are targeted and how those these elements are transpositionally extinct. approximately 50% of the , occur. The purpose of this study was However, though they may no longer be although the majority are transpositionally to elucidate whether these types of mutations capable of motility or replication, they may extinct [1]. For instance, many autonomous are increased in autism due to an inherent still affect local DNA conformation, interaction retrotransposons contain mutations which no genomic instability of these regions in the with binding partners leading to alterations longer make synthesis and therefore human genome. The causes for such mutations in , and the overall stability of retrotransposition possible; therefore, they may vary. For example, individuals with Li- the local genomic region [9-11]. These are the may produce transcripts but are nonetheless Fraumeni syndrome, an autosomal dominant reasons we wished to investigate a potential considered extinct. Interestingly, some genes disorder characterized by increased risk to relationship between autism-risk genes and which house numerous TE, both mobile and various neoplasms, exhibit genomes enriched the occurrence of TE within those gene regions. extinct, are known to exhibit relative genetic in CNVs suggesting that these variants may instability, suggesting that transposition and predispose towards the genomic instability 2. Experimental procedures retrotransposition are not the only TE-related which gradually characterizes advanced stages events which may affect rates of of tumorogenesis [5]. While the chromosomal The newest version of AutismKB database, [2, for example]. rearrangements which typify advanced cancer “nonsyndromic_list20121018,” was downloaded A broad array of genes have been identified are an extreme example for comparison to from the website [3]. Our autism-risk genes as risk factors for autism, so many that it autism, tendencies towards instability may were selected according to Total Score, a system is a challenge to find a common thread be similar, targeting related groupings of which ranks from 0-50. Each gene’s rank is a throughout. At present, the most recent version inherently less stable genes. “Weaker genes” compilation of scores comprising 1) genome- of the database, AutismKB, lists 3,049 genes may therefore be inherited, as seen in Fragile wide associations studies, 2) expression studies,

* E-mail: [email protected]

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3) copy number variants studies, 4) linkage general distribution, with autism-related genes our autism group displayed more TE per studies, 5) low-scale association studies, and displaying significantly higher numbers of total gene than our controls [autism: N = 441, 6) other low-scale association studies. In TE content [N = 508, D = 0.2090]. We went on μ = 132, ± 300 s.d.; control: N = 441, μ = 45, order to select those sequences with stronger to perform a logistic regression utilizing our full ± 106 s.d.]. In addition, approximately 7% of association to autism, we collected a listing of data set, finding that for every doubling of TE the autism genes housed extraordinarily large genes with rankings greater than or equal to content, a given gene was approximately 17% numbers of TE, ranging from 500 to well over 10 [N = 441, following exclusion criteria below]. more likely to be associated with our autism 2,000 per gene, while only approximately 1% Our 441 control genes were then selected group [OR = 1.17, CI = 95%, p-value = 5.56 x 105]. of controls reached the 500-999 range and utilizing the random gene generator available Overall, 67% of the genes from our only one gene out of 441 tallied over 1000. Our through RSAT, which provides a listing of autism sample housed TE while only 48% results suggest a strong relationship between protein-coding Ensembl ID’s [12,13]. From our of our control group exhibited the same the total TE content of a given gene and its randomized group, genes were cross-checked (Table 1 and Figure 1). As mentioned, risk for mutation, results which may hold against the AutismKB database and excluded if listed therein. We then downloaded the RefSeq Table 1. This table shows the number of transposable elements per gene per group. A descriptive analysis database, “gene2refseq,” and cross-checked all illustrating the percentage breakdown in autism and controls, separated by total size of TE content. our samples, removing any which do not occur within RefSeq so as to exclude those genes # TE/Gene Autism Control which do not appear within the TranspoGene 0 32.88% 51.93% database (downloaded: 3/12/13). All 1 2.04% 1.13% transposable content from Human Genome 17 2 1.13% 2.04% (hg17) was downloaded from the TranspoGene database [14]. Once all data were collected, 3-5 2.72% 3.17% due to the nature of our distributions, for our 6-10 3.17% 2.95% first analysis a nonparametic Kuiper test was 11-50 18.37% 17.46% performed which addressed the relationship of 51-100 12.93% 9.07% total TE content by group. Both our full data set and a reduced set (excluding zero-values) were 101-200 9.30% 5.67% analyzed. For our second analysis, a logistic 201-500 10.20% 4.99% regression was applied, utilizing TE content as 501-1000 5.67% 1.36% our independent variable and group (autism 1001-2000 1.13% 0.23% v. control) as our dependent variable. Please note that this data is reflective of the state of 2001-3000 0.45% 0.00% current knowledge at the time of acquisition, which may be subject to change as databases are updated (for full data set, see Appendix 1).

3. Results and discussion

Our autism and control groups were built using data from two databases, AutismKB and TranspoGene, and occurrences of TE were determined for each gene. From the results of our analysis utilizing a nonparametric Kuiper test, it was clear that our autism genes housed significantly greater numbers of transposable elements as compared to randomized controls [N = 882, D = 0.2177, p-value = 4.321 x 108]. Upon removal of all TE zero-values, an additional Kuiper test likewise returned a p-value of 6.187 x 104, indicating that substantial differences Figure 1. A histogram showing numbers of TEs across autism and control genes. The greatest differences lie in the lay not only in the occurrence of TE but in their occurrence of genes with no TE content (autism < control) and in numbers of large TE content (100+).

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relevance for disease susceptibility in multiple for additional risk-genes of the condition Acknowledgments conditions such as autism, , and and in pinpointing factors, inherited and cancer [15,16]. ecological, which underlie autism-related A special thanks to Lena McCue for taking the Our results are particularly relevant mutations. Such knowledge can help us time to review the manuscript and offer critique. concerning two recent publications, those of better understand what lies at the core of this The work in this manuscript was supported by the Cross-Disorder Group of the Psychiatric heterogeneous condition and offer us greater funding from the National Institutes of Mental Genomics Consortium [17] and Girirajan means of intervention. Health (NIMH) RO1 MH086784. et al. [18]. The first study identified several common major risk loci for autism, AD/HD, schizophrenia, , and major depression, some of which included loci within calcium channel activity genes [17]. Interestingly, the set of 73 calcium channel- related genes, which the Consortium studied in depth, likewise houses large TE content similar to our autism grouping, particularly the ratio of large TE content (100+) [μ = 166, ± 225 s.d.] (Figure 2). The second study by Girirajan and collaborators looked at hotspots in autism- rich candidate genes which house CNVs that break or disrupt these genes [18]. The authors highlighted seven genes in particular which stood out due to high CNV enrichment. Five of these seven are likewise highly enriched in TE Figure 2. A histogram showing numbers of TEs across calcium channel activity and autism-risk genes from our own data set, the former originally studied by the Cross-Disorder Group of the Psychiatric Genomics content, once again suggesting a relationship Consortium (2013). Like those genes included within our own autism group, these calcium channel between mobile element content and genomic activity genes display similarly enhanced TE content with approximately 60% displaying large numbers of mobile elements per gene (100+). instability (Figure 3). There has been a growing interest in the epigenetics of autism [19,20]. Since it has become clear that no single gene or small constellation of genes underlies the condition, attention has turned towards a more complex understanding of its potential etiology, one involving not just mutability but the control of gene expression. However, the epigenome is not only an important regulator of gene expression but a modulator of genomic stability [21]. Of relevance to our data, the role which epigenetic regulation plays in the suppression of TE transposition is well documented [22]. It suggests that autism-risk genes may not only be more susceptible to mutation in general but that they may also be vulnerable to specific mutagens and epimutagens. Our results provide a framework for Figure 3. Total number of transposable elements as well as total numbers of long interspersed elements (LINE), understanding what types of genes may short interspersed elements (SINE), long terminal repeats (LTR), and DNA transposons in these seven play roles in the development of autism, autism-rich candidate genes originally reported in Girirajan et al., 2013 [18]. Note that four of the seven genes which house CNVs which break or disrupt the genes contain unusually large numbers of and specifically how the content of those transposable elements (> 1000), an occurrence which only occurs in the top 2% of the autism-risk genes genes lends towards genetic instability. This within our own study. HYDIN, though not containing > 1000 TE, nevertheless contains relatively large TE content. This study echoes the findings of our own, suggesting increased risk of mutation with higher understanding may allow scientists a greater TE content. At present, only FHIT is included within the current version of the AutismKB database and predictive capacity in continuing the search therefore shares overlap with our data set.

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175 Translational Neuroscience 0 4 2 0 1 0 0 4 0 0 1 0 4 0 0 0 0 1 0 0 0 0 0 3 1 4 1 0 0 TE content Non-intronic Non-intronic 0 0 0 0 0 0 0 1 70 22 content Intronic TE Intronic 0 0 72 26 196 195 247 246 3946 3942 Total TE Total content 10 0 10 8210 78 17 10 4711 47 14 0 1011 13 13 12 26 20010 200 36 36 11 14 30811 305 12 11 1012 330 326 22 1 score Autism KB Autism 2 20 128 191 154 211 280 481 321 434 552 4363 9915 55902 1027125 130 14 130 15956311 158 10 0 5662410973 10 10 9384239 452 92 452 26053 23 1488 1488 57492 23 1417 1417 51327 79798 57194 26033 10 0 154664 10 0 203859 10 118170302 118 16 95 95 Entre ID Entre 9q34 4q23 5q31 7q31 6q16 3q29 3p21 1p21 7p13 15q12 10q26 16p11 6q25.3 1q24.2 7p12.3 Xp21.3 15q25.1 16p13.1 16p11.1 11p15.1 Location 20q11.22 20q11.22 10q11.23 12p13.31 5q31-q32 15q11-q12 12q14-q15 20q11.2-q12 Xp22.3 and Yp11.3Xp22.3 and 438 Gene name alpha-2-macroglobulin sub-family member 13 A (ABC1), cassette, ATP-binding sub-family member 2 A (ABC1), cassette, ATP-binding sub-family member 1 C (CFTR/MRP), cassette, ATP-binding acyl-CoA short-chain synthetase family member 2 5 (class III), chi polypeptide dehydrogenase alcohol beta 2, surfaceadrenoceptor member 4 family, AF4/FMR2 adenosylhomocysteinase alpha stabilizing protein 1 delta-, synthase aminolevulinate, alpha 2B (pancreatic) amylase, ankyrin domain 7 repeat anoctamin 5 family A, member protein-binding, precursor beta (A4) amyloid 2 domain 1B (SWI1-like) rich interactive AT 5 containing armadillo repeat 2 nuclear translocator aryl-hydrocarbon aristaless related (non-lysosomal N-acylsphingosine amidohydrolase 2 ceramidase) subunit 3 1 complex cointegrator activating signal protein agouti signaling O-methyltransferase acetylserotonin type 10A V, class ATPase, type 13A4 ATPase Na+/K+ transporting, beta 1 polypeptide ATPase, attractin-like 1 2 autism susceptibility candidate 1A receptor vasopressin arginine ARX ASIP A2M AFF4 Gene AHSP AHCY ASMT ADH5 ANO5 ACSS2 ALAS1 AUTS2 ASCC3 APBA2 ABCC1 ARNT2 ABCA2 ASAH2 ADRB2 AMY2B ARMC5 ARID1B ATP1B1 ATP10A ATRNL1 AVPR1A ABCA13 ANKRD7 ATP13A4 Group AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM Appendix 1. Appendix

176 Translational Neuroscience 2 1 0 0 0 0 8 0 2 0 0 1 0 1 0 0 0 0 0 2 0 1 0 0 0 1 1 0 0 3 19 0 0 0 4 0 0 13 13 38 37 33 33 98 98 202 200 174 174 44049 43565 484 11 11 1010 176 176 62 62 34 15616 148 37910 379 3610 34 278316 2783 87711 876 21 181010 1801 519 1801 10 43 519 169 43 167 11 2329 1687 1668 61 60 11 11 12 10 157016 1570 40 39 14 4 11 649 696 721 777 596 778 627 773 796 952 9274 8912 8573 1007 5218 1990 1106 8618 1008 23774 92558 15 0 55799 10 1105 1105 11126 23705 24 274 273 64405 15 94 91 10295 64755 90835 400073 10 70 69 130940 14 319 319 253782 14 394 394 2q31 8p21 5p14 12q13 15q26 16p11 19p13 1q25.3 2q24.1 1q21.2 6p22.1 6p21.3 3p21.1 3p21.1 5p14.2 Xp11.4 18q21.3 11q23.2 20q13.1 16p11.2 11p14.1 16p11.2 16p11.2 11p15.2 4p15.32 22q13.33 12q24.11 12q24.23 7q21-q22 19p13.3-p13.2 718 branched chain ketoacid dehydrogenase kinase dehydrogenase chain ketoacid branched B-cell CLL/lymphoma 2 B-cell CLL/lymphoma 7C factor -derived neurotrophic 1 bone morphogenetic protein 1 containing bromodomain subfamily 1, member A1 butyrophilin, 76 frame 12 open reading 58 frame 16 open reading chromosome 93 frame 16 open reading component complement blood group) 4B (Chido component complement voltage-dependent,calcium channel, alpha 1A P/Q type, subunit voltage-dependent,calcium channel, alpha 1E subunit R type, voltage-dependent,calcium channel, alpha 1F subunit L type, alpha 1H subunitT type, voltage-dependent,calcium channel, voltage-dependent,calcium channel, alpha 2/delta subunit 3 Xp11.23 adhesion molecule 1 cell 16p13.3 activator Ca++-dependent secretion polypeptide alpha calcitonin-related calcium/-dependent kinase serine protein (MAGUK family) 148 coiled-coil domain containing 64 coiled-coil domain containing CD160 molecule CD38 molecule cadherin 10, type 2 (T2-cadherin) cadherin 22, type 2 cadherin 9, type 2 (T1-cadherin) cyclin-dependent kinase 14 member 1 -like family, 6 synthase ceramide 2 helicase DNA binding protein chromodomain C3 C4B BCL2 CASK BRD1 CD38 BDNF BMP1 CDH9 CHD2 CERS6 CELA1 BCL7C CALCA CD160 CDK14 CADPS BCKDK CDH10 CDH22 CADM1 BTN1A1 CCDC64 C12orf76 C16orf58 C16orf93 CCDC148 CACNA1F CACNA1E CACNA1A CACNA1H CACNA2D3 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

177 Translational Neuroscience 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 1 1 0 0 9 0 0 2 0 0 0 0 0 0 0 0 9 4 3 0 0 0 0 0 0 0 0 3 176 9 0 0 0 20 19 37 37 163 163 209 209 1497 1488 16 0 18 50 50 12 12 12 1417 22910 229 3 1411 1521311 152 1 11 2611 26 14 0 1011 0 16 177 10 98 200 97 22 200 1013 3514 0 35 23715 23713 11 11 21 12 1312 8220 1139 1141 4849 1303 1358 1489 1509 1601 1621 4921 1742 1750 1756 1339 4051 26047 42 2794 2794 83992 10 16328988 163 10 28 28 64478 27185 54487 23283 29119 1423191 1844 1844 91614 10 0 283971 10163882 4 10 154 154 1q44 7q35 7q32 7q31 9q34 5p13 7p13 10q11 10q21 15q11 11p13 1q21.3 1q42.1 7q21.3 8p23.2 Xp21.2 15q13.3 16q22.1 19q13.4 22q11.2 16p11.2 100132341 16p11.2 11p15.5 17p13.1 22q11.21 22q11.21 16p11.12 19p13.12 6q12-q13 1q12-q23 12q23-q24.1 1407 6q13-q22.33 28514 10 3 20q13.2-q13.3 1137 cholinergic receptor, nicotinic, alpha 4 (neuronal) nicotinic, receptor, cholinergic alpha 7 (neuronal) nicotinic, receptor, cholinergic beta 2 (neuronal) nicotinic, receptor, cholinergic C-type lectin domain family 18, member C homolog pseudogene 3 (cluA/CLU1) mitochondria clustered subunit 3 complex, transcription CCR4-NOT consortin, sorting connexin protein 2 protein-like contactin associated typecollagen, XII, alpha 1 catechol-O-methyltransferase VIa polypeptide 2 subunit cytochrome c oxidase carboxypeptidase A2 (pancreatic) cryptochrome 1 (photolyase-like) CUB and Sushi multiple domains 1 pre-RNA, subunit 2, 64kDa, tau 3’ factor, stimulation cleavage variant 1 cardiotrophin alpha 3 protein), (cadherin-associated catenin D cortactin 2 binding protein 1 protein interacting cytoplasmic FMR1 polypeptide 3 cytochrome P450, family 4, subfamily F, homolog 2 phosphoprotein, mitogen-responsive Dab, (Drosophila) (dopamine beta-monooxygenase) dopamine beta-hydroxylase drebrin-like kinase tyrosine 2 domain receptor discoidin 7 DEP domain containing gene 14 critical region syndrome DiGeorge gene 8 critical region syndrome DiGeorge 1 in schizophrenia disrupted homolog 4 (Drosophila) large discs, delta-like 1 (Drosophila) 6 distal-less homeobox DBH CTF1 DLL1 CPA2 CRY1 DMD DLX6 CNST CTSD DLG4 DAB2 DBNL DDR2 DISC1 COMT CYFIP1 CNOT3 DGCR8 CSTF2T CSMD1 CYP4F3 CLUHP3 COX6A2 DEPDC7 DGCR14 CHRNB2 CTNNA3 CHRNA4 CHRNA7 CLEC18C COL12A1 CTTNBP2 CNTNAP2 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

178 Translational Neuroscience 1 0 0 0 0 0 0 5 0 3 3 0 0 0 1 0 5 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 1 0 0 2 0 4 9 2266 1 0 0 0 39 36 22 22 52 51 222 222 2271 161315 28910 0 10 546 288 23 0 23 546 10 496 1278 496 12 1273 14 6761024 676 10 3110 39530 31 13 394 11 141 282 141 281 11 17 22 1 1111 2 667 8448 1813 1815 1859 8894 8178 1767 9732 1806 1814 1845 1977 2002 2020 2103 83658 10 43 40 29902 26261 1355079 52 52 79813 10 150 150 23312 10 220 220 64118 10 0 5462964319 1054620 0 27006 10 4 128853 10 14 14 283932 284254 14 10 157769 10 42254170389549 41 19 52 52 7q22 1p22 17q21 7q31.1 3q13.3 9q34.3 7q36.2 5p15.2 6p12.1 3p21.1 15q21.2 17q25.3 18q21.2 14q24.3 15q21.3 8q24.13 14q13.3 7q31.32 16p11.2 11p15.5 19p13.1 16p11.2 16p11.2 16p11.2 19p13.3 Xp11.23 20q11.21 20q11.21 21q22.13 12q24.11 4q21-q25 11q22-q23 Dmx-like 2 Dmx-like heavy chain 5 dynein, axonemal, alpha double C2-like domains, of cytokinesisdedicator 4 dehydrogenase dihydropyrimidine D2 D3 dopamine receptor dystonin 1-like (S. cerevisiae) synthase dihydrouridine dual specificity 15 phosphatase dual specificity 3 phosphatase dynactin protein associated 1 chain, roadblock-type dynein, light dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 1 histone-lysineeuchromatic N-methyltransferase eukaryotic factor initiation 2, subunit 2 beta, 38kDa translation eukaryotic factor initiation 4E translation ELK1, member of ETS family oncogene 20q11.2 factor II elongation RNA polymerase 2 homeobox beta receptor estrogen-related similarityfamily with sequence 216, member A similarityfamily with sequence 63, member B similarityfamily with sequence 91, member A1 fibrosin and leucine-rich 19 F-box protein repeat head) RNA 1 (head to FBXL19 antisense 24 protein F-box 33 protein F-box FEZ family 1 FEZ family zinc finger 2 factor 22 growth fibroblast ELL DST EN2 ELK1 FBRS EIF4E DPYD DRD2 DRD3 DRD4 FEZF1 FEZF2 ESRRB FGF22 EIF2S2 DUS1L DUSP3 DYNAP EHMT1 DOCK4 DMXL2 FBXL19 DOC2A DNAH5 FBXO24 FBXO33 DUSP15 DYRK1A FAM63B DYNLRB1 FAM216A FAM91A1 FBXL19-AS1 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

179 Translational Neuroscience 1 0 1 0 4 0 0 1 4 0 0 0 0 0 0 0 0 0 2 1 0 1 0 0 2 0 0 0 0 0 0 11 9 4 0 0 7 0 8 9 78 67 71 71 74 74 166155 165 155 25 283 282 10 52 52 1610 182410 9 1823 157112 1567 11 12 22 251634 0 16 52125 48210 521 0 482 65 871011 65 206 87 10 206 1010 0 10 38 98 23 37 98 23 1019 489 1254 489 1254 12 2332 2686 2312 2335 2444 2521 2555 2557 2558 2560 2562 2567 2571 2580 2620 2670 2731 2743 2767 2873 2898 2272 93986 33 428 428 84059 10 512 512 27086 23 1058 1058 54584 374378 14155038 477 10 477 40221188 39 10285513 65 10 63 124274 15 105 105 2q34 7q31 2q31 5q13 4p12 4p12 4p12 4p16 9p22 15q12 15q12 15q12 17q21 16q13 11p15 1q21.3 7q36.1 4q31.3 4q22.1 6q16.3 3p14.2 3p14.1 Xq27.3 22q11.2 17q25.3 16p11.2 11p14.3 19p13.3 20q11.22 16p13.11 6q21-q22.3 6p21.3-p21.1 2739 fragile histidine triad fragile filaggrin 1 retardation X mental fragile fibronectin 1 P1 forkhead box P2 forkhead box kinase fyn-related fused in sarcoma alpha 2 A receptor, gamma-aminobutyric acid (GABA) alpha 4 A receptor, gamma-aminobutyric acid (GABA) alpha 5 A receptor, gamma-aminobutyric acid (GABA) beta 1 A receptor, gamma-aminobutyric acid (GABA) beta 3 A receptor, gamma-aminobutyric acid (GABA) gamma 3 A receptor, gamma-aminobutyric acid (GABA) 67kDa) decarboxylase 1 (brain, glutamate kinasecyclin G associated UDP-N-acetyl-alpha-D-galactosamine:polypeptide 18 N-acetylgalactosaminyltransferase 2 arrest-specific growth glial fibrillary acidic protein 7 gamma-glutamyltransferase family member 8 IMAP GTPase, (decarboxylating) dehydrogenase I glyoxalase beta receptor, glycine alpha 11 (Gq protein), (G guanine nucleotide binding protein class) beta protein), (G guanine nucleotide binding protein polypeptide 1-like 114 receptor G protein-coupled 139 receptor G protein-coupled 98 receptor G protein-coupled GPRIN family member 3 1 suppressor pathway G protein kainate 2 ionotropic, receptor, glutamate FLG FRK FUS FN1 GAK FHIT GPS1 GFAP GLRB GAS2 GLO1 GGT7 FMR1 GLDC GAD1 GRIK2 GPR98 FOXP1 FOXP2 GNB1L GNA11 GPRIN3 GPR114 GPR139 GIMAP8 GABRB1 GABRB3 GABRA2 GABRA4 GABRA5 GABRG3 GALNT18 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

180 Translational Neuroscience 0 0 0 4 0 0 0 2 0 0 6 0 1 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 1 0 0 0 0 4 3 0 0 0 0 0 0 4 0 27 4 3 0 4 527182 526 182 1614 1608 131417 0 4921413 492 23 692 881 692 3710 881 19 37 12 5111 10 51 10 11 131033 0 10 0 10 16 115 0 16 10 115 1020 3316 21412 0 33 161 214 14 159 11 36411 364 11 1 2903 2904 2925 8479 3185 3265 3360 2915 2937 2944 2969 3002 3012 3123 8091 3146 9456 3198 3358 23426 13 230 226 94239 10 28 23199 16 35 35 84717 10 108 108 23526 10 2880270 28 116444 146395 10 210 208 440362 128872 10 0 222537 6q21 7p13 Xq23 12q15 13q12 12p12 16p11 5q14.2 1p13.3 6p22.1 6p21.3 7p15.2 Xp22.2 11q14.3 16q24.1 20q11.2 7q11.23 14q11.2 16p13.2 19p13.3 16p11.2 19p13.3 16p12.1 19p13.3 11p15.5 16p11.2 12q13.13 20q11.22 10q11.21 7q31.3-q32.1 2918 1p36.13-p36.12 3399 , ionotropic, N-methyl D-aspartate N-methyl 2A ionotropic, receptor, glutamate D-aspartate N-methyl 2B ionotropic, receptor, glutamate N-methyl-D-aspartate 3B ionotropic, receptor, glutamate 1 protein interacting receptor glutamate 5 , glutamate 8 metabotropic receptor, glutamate receptor gastrin-releasing Gse1 coiled-coil protein GSG1-like synthetase glutathione mu 1 S- glutathione factor transcription general IIi T-lymphocyte-associated B (granzyme 2, cytotoxic 1) serine esterase V member family, H2A histone 2 protein factor-related hepatoma-derived growth hect domain and RLD 2 pseudogene 4 3 HIRA protein interacting 1, H2ae cluster histone class II, DR beta 1 complex, major histocompatibility 2 AT-hook high mobility group 1 box high mobility group 3 pseudogene 1 box high mobility group (minor) HA-1 histocompatibility F nuclear ribonucleoprotein heterogeneous homer homolog 1 (Drosophila) A1 homeobox homolog oncogene viral Harvey sarcoma v-Ha-ras rat 5 3-O-sulfotransferase (glucosamine) sulfate heparan 3 beta- and steroid dehydrogenase, hydroxy-delta-5-steroid 7 delta- 2C, G protein- receptor (serotonin) 5-hydroxytryptamine coupled 4, G protein-coupled receptor (serotonin) 5-hydroxytryptamine helix-loop-helix negative of DNA binding 3, dominant inhibitor protein 5q31-q33 ID3 GSS GSE1 HTR4 GRPR HRAS GTF2I GRIP1 GRM5 GRM8 GZMB HIRIP3 GSG1L HTR2C H2AFV GSTM1 HOXA1 HS3ST5 GRIN2B GRIN3B HMGB1 GRIN2A HMGA2 HMHA1 HSD3B7 HNRNPF HOMER1 HERC2P4 HDGFRP2 HMGB3P1 HLA-DRB1 HIST1H2AE AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

181 Translational Neuroscience 0 3 0 0 3 0 3 0 0 0 0 0 0 0 0 0 0 1 0 1 1 0 0 7 0 0 0 0 0 0 0 0 0 0 57 57 20 20 27 27 93 92 49 48 35 35 994 994 554 554 244 244 543 543 22 11 12 20 209 206 2511 195316 1950 34 34 15 42 42 10 12 11 1511 283 283 1614 442 998 441 16 998 10 40 616 40 609 11 11 3689 3690 3778 9703 7850 3678 3684 3687 3720 3751 3752 57805 10 16 16 83943 83737 10 314 311 23081 23189 64207 10 0 83473 15 160 160 23592 10 114 114 84148 22859 10 190 190 221037 14 0 144501414332 10375612 10 20 13 0 20 696 696 145581 19 307 307 2q12 7q31 7q31 8p22 10q22 12q14 9q34.3 7q22.2 9p24.3 1p13.2 14q24.3 21q22.3 10q22.1 18q21.1 17q11.2 16p11.2 16p11.2 16p11.1 19p13.2 20q11.22 17q21.32 12q13.13 6p24-p23 9p24-p23 12q11-q13 16p13.1-p11 3681 6p22.3-p22.2 9856 Xp22.1-p21.3 11141 23 3418 3418 16p12.1-p11.2 23247 Xp11.22-p11.21 8242 interleukin 1 receptor, type II interleukin 1 receptor, 1 accessoryinterleukin protein-like 1 receptor peptidase-like membrane IMP2 inner mitochondrial (S. cerevisiae) regulatoryinterferon factor 2 binding protein-like E3 ubiquitin protein itchy alpha polypeptide) receptor, alpha 5 (fibronectin integrin, alpha D integrin, 3 3 receptor component alpha M (complement integrin, subunit) 4 3 receptor component alpha X (complement integrin, subunit) 3 and 4 3 receptor component beta 2 (complement integrin, subunit) CD61) IIIa, antigen glycoprotein beta 3 (platelet integrin, domain 2 rich interactive jumonji, AT 1C jumonji domain containing KN motif and ankyrin domains 1 repeat 8 acetyltransferase K() katanin 2 p60 subunit A-like subfamily, potassium voltage-gated Shal-related channel, member 2 subfamily, potassium voltage-gated Shal-related channel, member 3 conductancechannel, calcium-activated potassium large subfamily M, alpha member 1 (K)-specificlysine 4C demethylase (K)-specificlysine 5C demethylase KIAA0100 KIAA0319 KIAA0556 KIAA1967 80 keratin lipocalin 10 3 LEM domain containing lipoma HMGIC fusion partner-like 3 1 and fibronectin containing leucine richtype III domain repeat 5 14q21.1 ITCH KAT8 IL1R2 ITGB2 ITGB3 ITGA5 ITGAX KRT80 ITGAD LRFN5 LCN10 ITGAM LPHN1 KANK1 JARID2 KCND2 KCND3 LEMD3 LHFPL3 KDM4C KDM5C IRF2BPL JMJD1C IMMP2L KCNMA1 KATNAL2 IL1RAPL1 KIAA0100 KIAA0319 KIAA0556 KIAA1967 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

182 Translational Neuroscience 0 0 4 0 4 1 0 0 0 0 0 1 2 0 0 0 0 0 1 0 1 1 0 1 0 0 0 0 0 1 0 11 14 0 4 2172 4 21 21 19 18 249 249 226121 226 121 177 177 641 641 2432 2432 17 19 2176 1514 44 149 40 148 11 14 0 2610 79 14127 79 140 2128 153 21 11 153 2616 14133 141 1075 1061 12 10 12 71 71 12 12 4035 5594 4152 8932 4648 5595 4139 4204 4208 4233 4585 4524 9172 54674 10 84557 10 34 32 84465 165484257496 63058508 14 629 10 66 591 66 590 55227 14 622 611 79648 79705 10 42 42 23026 84445 53615 10 30 30 79091 16 4410514 43 10 10 10 162333 10 162 162 399687 10 226 226 140733 23 87 87 1q41 5q14 7q31 7q36 3q29 Xq28 10q24 18q21 18q21 19p13 7q31.1 2q32.2 2q21.1 6p12.2 8p23.1 1p36.3 8p23.3 12q13.3 15q26.3 22q11.2 17q23.3 13q33.3 17q11.2 20p12.1 16p11.2 16p13.2 17p13.3 20q11.22 15q22.31 16p13.12 2q31.1-q31.2 140469 10 653 652 Xp11.4-p11.3Xp11.4-p11.3 4128 4129 low density lipoprotein receptor-related protein 1 protein receptor-related densitylow lipoprotein 1 containing leucine rich repeat leucine-rich kinase repeat 1 3 neuronal leucine rich repeat 2 tumor suppressor putative , 2 domain containing MACRO A monoamine oxidase B monoamine oxidase chain 3 alpha 1 light microtubule-associated protein kinase protein 1 mitogen-activated kinase protein 3 mitogen-activated membrane-associated(C3HC4) 10, E3 ubiquitin ring finger ligase protein affinity-regulating kinase 1 MAP/microtubule 1 binding domain protein methyl-CpG 2 binding domain protein methyl-CpG 3 binding domain protein methyl-CpG 1 microcephalin 2 (Rett syndrome) binding protein CpG methyl factor enhancer 2C myocyte multiple EGF-like-domains 11 factor receptor) met proto-oncogene (hepatocyte growth like 22 methyltransferase superfamilymajor facilitator 6 domain containing 2 MKL/myocardin-like leukemia 3 or mixed-lineage myeloid/lymphoid reductase (NAD(P)H) methylenetetrahydrofolate surfacemucin 4, cell associated (P160) 1a binding protein MYB XVI XVIIIA myosin IIIB myosin VIIB myosin 2 myomesin MET LRP1 MLL3 MKL2 LZTS2 MBD1 MBD2 MBD3 MUC4 LRRK1 MAOB LRRC1 MAOA LRRN3 MEF2C MECP2 MFSD6 MAPK1 MAPK3 MTHFR MARK1 MYO16 MYO3B MYO7B MCPH1 MYOM2 MEGF11 MYO18A METTL22 MYBBP1A MARCH10 MACROD2 MAP1LC3A AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

183 Translational Neuroscience 0 0 2 0 0 1 0 0 1 0 0 2 1 0 0 7 1 1 0 0 0 0 0 0 1 4 0 1 0 0 0 1 97 0 6 0 1 3 0 0 0 0 0 19 76 22 127 117 122 2 81 80 21 77 360 360 14 0 15 6890 6793 12 12 1620 19610 196 6 128 1640 0 1014 118 124 118 10 1028 40019 0 399 0 1015 0 0 11 12 11 4684 4763 9379 4909 9891 5013 5021 4790 4897 4908 5047 5080 4803 9378 10787 10 326 326 22829 8161422871 14 13 126 953 953 57532 10 44 44 23054 10 298 297 5441357502 26 38 23 416 416 50863 14 572 572 89797 14 1124 1124 93129 123606 20 99204801 97 115677 10 82 82 114880 13124222 312 10 312 391189 10 0 2q32 4q24 7q31 1q44 9q34 2p15 3p25 20q11 11q13 11q25 12p13 16p13 11p13 2q31.1 2q32.1 1p13.1 2p16.3 Xq13.1 11q23.2 17q11.2 15q11.2 15q11.2 3q26.32 19q13.3 12q23.3 17q11.1 11p15.1 16p11.2 Xp22.33 Yq11.221 19q13.43 7q31.1-q31.3 51691 10 3 19p13.2-p13.1 4854 N(alpha)-acetyltransferase 38, NatC auxiliary 38, NatC N(alpha)-acetyltransferase subunit 2 navigator neuron adhesion molecule 1 cell neural 1 protein NCK-associated 6 coactivator 1 neurofibromin nuclear factor of kappa in polypeptide gene enhancer light B-cells 1 factor (beta polypeptide) nerve growth 1 syndrome in Prader-Willi/Angelman non imprinted 2 syndrome in Prader-Willi/Angelman non imprinted 1 neuroligin 3 neuroligin 4, X-linked neuroligin Y-linked 4, neuroligin 11 domain containing pyrin NLR family, trafficker synthase nitric oxide 3 notch adhesion molecule cell neuronal 1 neurexin 2 neurexin 3 neurotrophin 4 neurotrophin neurotrimin SNF1-like kinase, 1 family, NUAK protein interacting protein retardation X mental nuclear fragile 2 family 11, subfamily L, member 1 , ORAI calcium release-activated 3 calcium modulator 6 binding protein-like oxysterol orthodenticle 1 homeobox receptor oxytocin endometrial protein progestagen-associated family member IV and adipoQ receptor progestin 6 box paired NF1 NGF NTM PAEP PAX6 NTF3 NTF4 OTX1 NAV2 OXTR NIPA1 NIPA2 ORAI3 NFKB1 PAQR4 NAA38 NLGN1 NLGN3 NRXN1 NRXN2 NUAK1 NCOA6 NUFIP2 NCAM1 NRCAM NLRP11 OSBPL6 OR11L1 NCKAP1 NLGN4Y NLGN4X NOTCH3 NOSTRIN AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

184 Translational Neuroscience 0 1 0 0 1 2 2 0 0 0 1 5 3 0 0 0 7 0 1 0 0 0 0 0 0 3 0 0 0 0 0 3 0 0 0 0 7 0 0 3 0 6 2 0 0 0 3 0 0 15 15 44 39 8072 73 72 24 23 21 21 14 14 256 255 509 506 11 16 0 17 10 51 49 1010 3810 152 38 8 12 152 22 1012 84 84 11 11 10 50 50 10 1621 2448 2445 11 11 11 12 2 11 5307 5439 5444 8493 5551 5625 5728 5905 5187 5261 5430 5442 5579 5613 5652 2605611069 10 19 41 370 41 370 57575 23469 14 8191584 81 23126 15 197 197 11281 15 508 508 81488 10 9 83394 10 154 154 78994 29108 128869 10375775 262 10 261 246721 119548644 10 119 10 41 0 39 115727 14 146547 260434 6q12 2p13 10q22 10q23 22q13 17p13 16p12 4q28.3 5q31.1 7q32.3 9q34.3 1q21.1 7q11.2 7q22.1 7q22.1 7q21.3 7p14.1 Xp22.3 15q21.3 17q23.3 22q11.2 19q13.1 17p13.1 16p11.2 17p13.1 19p13.3 16p11.2 16p11.2 16p11.2 16p11.2 16p11.2 20q11.22 2q31-q32 7q22-q31.1 10156 protocadherin 10 protocadherin 1 period circadian 3 PHD finger protein phosphorylase kinase, gamma 2 (testis) class U anchor biosynthesis, glycan phosphatidylinositol PITPNM family member 3 homeodomain 1 paired-like A4 plexin 7 phospholipase domain containing patatin-like with ZNF domain element pogo transposable polypeptide A, 220kDa II (DNA directed) (RNA) polymerase 13.3kDa polypeptide J, II (DNA directed) (RNA) polymerase polypeptide J2 II (DNA directed) (RNA) polymerase polypeptide J3 II (DNA directed) (RNA) polymerase polypeptide M II (DNA directed) (RNA) polymerase (DNA directed) mitochondrial (RNA) polymerase 1 paraoxonase 2 POU class 6 homeobox Mg2+/Mn2+ 1D dependent, phosphatase, protein perforin protein) forming 1 (pore kinaseprotein C, beta kinase, X-linked protein 1 (oxidase) dehydrogenase proline rich 14 proline 36 serine, protease, 8 serine, protease, homolog and tensin phosphatase and CARD domain containing PYD 1 domain) containing (pyrin PYD 5 (class I) RAB11 interacting 1 activating protein Ran GTPase 4 factorRap (GEF) guanine nucleotide exchange 4 activator RAS p21 protein 4 protein releasing RAS guanyl PIGU PRF1 PER1 PRKX PTEN PHF3 PITX1 PON1 POGZ PRSS8 PRR14 PRKCB RASA4 PYDC1 PHKG2 PPM1D PRSS36 PRODH POLR2J PNPLA7 PLXNA4 POLR2A POU6F2 PYCARD PCDH10 POLRMT POLR2M POLR2J2 POLR2J3 PITPNM3 RAPGEF4 RASGRP4 RANGAP1 RAB11FIP5 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

185 Translational Neuroscience 0 0 0 0 0 0 0 2 0 0 0 0 1 0 0 1 1 2 2 0 1 0 2 0 0 1 1 2 0 0 0 0 0 5 0 0 0 22 170 84 83 43 42 41 41 463 463 171 128 128 11 12 12 101018 11410 63 114 5 16 87 63 20 0 85 67 67 4310 537 35812 536 358 17 1210 12 23 120616 24 1205 203 201 22 12 15 92 90 27 11 950 9733 6305 6323 6326 5649 5990 9783 6095 6134 9739 6561 9037 22999 13 495 495 55209 10 0 56963 10 42 42 55197 10 135 135 2294185358 16 25 232 0 231 23168 10 29106 10 64 62 54715 32 4175 4175 26470 57084 348093 10731220 64 14 64 0 124925 10 586 586 114571 16 38 38 158800 7q22 Xq24 Xq28 15q14 15q21 2q11.2 4q21.1 2q24.3 2q24.3 5p15.2 3p25.3 15q22.3 15q26.1 18q12.2 17q11.2 11q13.2 22q13.3 11q12.3 16p13.3 19p13.3 16p11.2 16p12.1 11p14.3 12q24.11 22q13.33 6q12-q13 15q21-q22 1pter-p22.2 Xp22.2-p22.1 6197 16p11.2-p11.1 9810 19p13.3-p13.2 6294 RNA binding protein, fox-1 homolog (C. elegans) 1 homolog (C. fox-1 RNA binding protein, with multiple splicing 2 RNA binding protein regulatoryexpression) factor HLA class II X, 2 (influences RFX family member 8, lacking RFX DNA binding domain member A RGM domain family, member 1 family, homeobox Rhox 1 exocytosis synaptic membrane regulating 3 exocytosis synaptic membrane regulating ligase 40, E3 ubiquitin protein ring finger protein A RAR-related L10 ribosomal protein of nuclear pre-mRNA 1A regulation domain containing S6 kinase, 90kDa, polypeptide 3 ribosomal protein homolog (S. component, II complex polymerase Rtf1, Paf1/RNA cerevisiae) factorattachment B scaffold 3 T cells by recognized antigen carcinoma squamous cell SET binding factor 1 member 2 class B, receptor scavenger III secretogranin voltage-gated,sodium channel, type I, alpha subunit voltage-gated,sodium channel, type II, alpha subunit (type 1 and type repeats thrombospondin sema domain, seven domain (TM)1-like), transmembrane and short cytoplasmic domain, (semaphorin) 5A SET 1A domain containing SET 5 domain containing 6 homolog () related seizure 6 homolog (mouse)-like 2 related seizure SH3 and multiple ankyrin domains 2 repeat SH3 and multiple ankyrin domains 3 repeat symporters), carriersolute family 13 (sodium/sulfate member 1 carriersolute family 17 (sodium-dependent inorganic ), member 6 phosphate 7q31.32 carrieranion transporter),solute family 22 (organic member 9 SBF1 RTF1 SEZ6 RFX2 RFX8 SAFB RELN SCG3 RORA RPL10 RIMS1 RIMS3 RGMA SART3 SETD5 RNF40 SCN1A SCN2A SEZ6L2 SETD1A SCARB2 RBFOX1 RPRD1A RHOXF1 RBPMS2 SHANK2 SHANK3 SEMA5A SLC13A1 SLC17A6 SLC22A9 RPS6KA3 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

186 Translational Neuroscience 1 0 0 0 0 0 2 0 0 5 2 0 0 1 0 0 0 0 0 1 0 0 0 6 2 0 0 0 0 2 0 0 0 0 0 6 0 0 2 6 0 32 32 10 10 52 52 245 244 176 174 115 114 150 150 174 174 12 11 12132 121 4010 40 421 421 10 278 276 11 10 0 21 1511 2511 25 27 11 11 14 0 10 489 487 11 11 6532 6548 6703 8128 6804 6812 8604 6524 6535 6810 9901 5421254221 14 10 968 0 968 10165 6492457181 15 86 85 79811 15 83 83 51111 16 158 158 53919 16 56 56 10847 23524 10 4 142680 10 0 285195 15 700 700 121340221178 441273 10 10 766 761 0 375611 10 562386757 562 2q24 7q22 2p25 Xq28 15q26 7q21.3 5q13.1 9q34.3 2q33.1 7q22.1 7q11.2 9q34.1 3p25.3 17q11.2 15q21.3 11q13.2 16p11.2 16p11.2 12p12.2 16p11.2 16p13.3 16p11.2 12q13.13 13q12.13 3q23-q24 8q11-q12 1q21-q22 16p12-p11 112755 10q23-q25 114815 10 1604 1598 1p36.1-p35 20p12-p11.2 6616 solute carriersolute family 25 (aspartate/glutamate carrier), member 12 carriersolute family 25 (aspartate/glutamate carrier), member 13 carriersolute family 26, member 5 () carriersolute family 30 (zinc transporter), member 5 member 3 carriersolute family 34 (sodium phosphate), carriersolute family 39 (zinc transporter), member 10 carrier cotransporter),solute family 5 (sodium/glucose member 2 creatine), transporter, carriersolute family 6 (neurotransmitter member 10, pseudogene serotonin), transporter, carriersolute family 6 (neurotransmitter member 4 creatine), transporter, carriersolute family 6 (neurotransmitter member 8 carrier proton solute family 9, subfamily A (NHE1, cation 1), member 1 carrier proton solute family 9, subfamily A (NHE9, cation antiporter 9), member 9 member 1C1 carrieranion transportersolute organic family, modulator transcription SAFB-like, 25kDa protein, synaptosomal-associated gamma 1 , gamma 2 syntrophin, 1 receptor VPS10 domain containing sortilin-related factorSp7 transcription 13 associated spermatogenesis speedy homolog E2 (Xenopus laevis) small proline-rich 2D protein protein CREBBP activator Snf2-related 3 activating protein Rho GTPase SLIT-ROBO matrix 2 repetitive serine/arginine 2 alpha-2,8-sialyltransferase ST8 alpha-N-acetyl-neuraminide 1A (brain) syntaxin 1B syntaxin 4 syntaxin 1 binding protein syntaxin 4-20 homolog 1 (Drosophila) of variegation suppressor SP7 STX4 SLTM STX1B STX1A SRCAP SNTG1 SNTG2 SRRM2 SLC5A2 SLC6A4 SLC6A8 SLC9A1 SLC9A9 STXBP1 SPDYE2 SNAP25 SPRR2D SORCS1 SRGAP3 ST8SIA2 SPATA13 SLC26A5 SLC30A5 SLC34A3 SLCO1C1 SLC25A12 SLC25A13 SLC39A10 SLC6A10P SUV420H1 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

187 Translational Neuroscience 0 3 0 0 0 0 0 1 1 4 0 0 1 0 0 1 4 0 0 1 0 0 0 0 1 0 1 0 0 0 0 2 0 2 0 0 2 0 0 1 2 9 77 12 712 277 2 0 2 78 65 61 319 319 478 478 12 15 51 48 10 42 42 10 3216 31 58216 582 22 17 0 10 27712 26 277 26 14 20 20 1010 2611 97 26 11 96 1 2017 354 353 9899 6856 6948 7204 7846 7337 9344 9496 6929 7041 7249 7273 50834 14 0 27010 10 716 10716 23 58476 10 10 10 11274 79718 10 278 23554 15 76 76 22846 13 14 11011 10 263 263 51760 13 251 251 27134 1058986 49 10 47 84231 10 9 256536 10 169 169 147798 10 20 19 114791 151531 20 168 167 116211 10 51 51 3q29 2q31 5p15 17q23 16p11 7q22.3 2q24.2 2q24.2 15q26.1 3q26.33 10q26.3 22q12.2 7q31.31 15q11.1 15q11.2 14q24.3 16p12.3 16p11.2 19p13.3 19p13.3 16p13.3 16p13.3 16p13.3 19q13.42 20q11.22 12q13.12 22q11.21 7q34-q35 17q21-q22 5p14-p15.1 7q31.3-q32 50831 15 0 11p15.3-p14 7166 Xp11.3-p11.23 7076 19p13.2-p13.11 5976 synaptic vesicle glycoprotein 2B glycoprotein synaptic vesicle 1 synaptophysin-like XVII synaptotagmin kinase 2 TAO type 2, member 1 receptor, taste type 2, member 3 receptor, taste 1 receptor (beta)-like 1 X-linked transducin 1 brain, T-box, 4 T-box 1-like regulator elongation transcription factortranscription 3 II transcobalamin 1 factor transcript beta 1 induced growth transforming 1 TIMP metallopeptidase inhibitor 3 junctiontight protein kinasetousled-like 2 4 L six family member 19 transmembrane channel-like 4 transmembrane 8A protein transmembrane 2 inducible nuclear protein tumor protein 1 tryptophan hydroxylase thiamin pyrophosphokinase 1 ligase factor 7, E3 ubiquitin protein TNF receptor-associated factortrio Rho guanine nucleotide exchange 2 sclerosis tuberous 12 tetraspanin tubulin, alpha 1a 5 protein associated tubulin, gamma complex ligase E3A ubiquitin protein homolog (yeast) of nonsense transcripts UPF1 regulator uridine phosphorylase 2 ubiquitin specific peptidase 18 1 vasohibin TTN TJP3 TRIO TLK2 TCF3 TPK1 TSC2 TBX4 TBR1 SV2B UPF1 TPH1 UPP2 TCN2 TMC4 SYPL1 SYT17 TIMP1 TRAF7 USP18 TAOK2 VASH1 UBE3A TAS2R1 TAS2R3 TUBA1A TGFB1I1 TBL1XR1 TMEM8A TCERG1L TSPAN12 TM4SF19 TUBGCP5 TP53INP2 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM

188 Translational Neuroscience 1 5 0 0 0 3 0 0 0 0 0 0 2 4 4 1 2 0 3 0 1 0 0 2 0 3 0 1 1 0 4 0 0 0 0 2 1 0 2 5 0 12 0 5 9 0 8640 86 40 17 17 11 11 14 50 49 25 25 194 193 00 2050 670 205 0 103 66 100 448 103 100 448 0 0 2002 2000 0 26 26 0 16 341 336 11 11 1015 948 164 944 10 162 1111 2 12 11 1 11 11 11 11 11 39 132 7432 7514 9889 8748 7472 7760 9726 9948 10097 2300192715 10 10 564 560 32 31 2303663925 10 10 0 35 35 22885 28976 80221 23305 80070 79001 10308 79759 92595 126017 10 3 137872 0 53 53 219749 10 255 252 146542 115509 124411 146540 140766 0 274 274 7q31 6q15 5q31 2p15 2p14 4q21.3 9q34.3 5q33.1 3q21.3 8q12.3 4p16.1 14q24.2 10q22.2 16p11.2 16p13.3 10p11.2 16p11.2 16p11.2 16p11.2 16p11.2 16p11.2 16p11.2 16p11.2 16p11.2 22q13.33 20q13.12 19q13.41 17q21.33 6q24-q27 6q25.3-q26 2q31.3-q32.1 151126 15 465 464 vasoactive intestinal peptide intestinal vasoactive subunit 1 reductase complex, vitamin K epoxide and FYVEWD repeat 3 domain containing domain 1 WD repeat domain 85 WD repeat wingless-type family member 2 MMTV site integration yeast) exportin homolog, 1 (CRM1 BED-type 4 containing zinc finger, 213 zinc finger protein 25 zinc finger protein 267 zinc finger protein 292 zinc finger protein 335 zinc finger protein 385B zinc finger protein 646 zinc finger protein 668 zinc finger protein 688 zinc finger protein 689 zinc finger protein 720 zinc finger protein 764 zinc finger protein 785 zinc finger protein 813 zinc finger protein member 3 family, binding LIM protein member 9 family, acyl-CoA dehydrogenase 2 acetyl-CoA acetyltransferase acyl-CoA family member 2 synthetase acyl-CoA long-chain synthetase family member 6 2 homolog (yeast) protein ARP2 actin-related metallopeptidase domain 20 ADAM 14 type 1 motif, metallopeptidase with thrombospondin ADAM 20 type 1 motif, metallopeptidase with thrombospondin ADAM 1 10q21 containing, iron dehydrogenase, alcohol adenosine kinase 12q12 VIP ADK XPO1 WNT2 WDR1 ACSL6 ACSF2 ACAT2 ACTR2 ZNF25 ZBED4 ACAD9 WDFY3 WDR85 ABLIM3 ZNF213 ZNF267 ZNF292 ZNF335 ZNF646 ZNF668 ZNF688 ZNF689 ZNF720 ZNF764 ZNF785 ZNF813 ADHFE1 VKORC1 ADAM20 ZNF385B ADAMTS14 ADAMTS20 AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM AUTISM CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

189 Translational Neuroscience 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 4 3 1 0 0 5 0 2 0 0 0 0 3 1 2 0 4 0 0 0 0 3 7 0 0 0 1 1 0 0 0 0 4 7 0 0 0 4 3 0 0 17 17 11 11 00 124 124 2600 26 14 280 14 0 28 168 168 0 0 0 295 295 0 0 0 1540 154 14 14 0 0 00 25 24 0 116 116 0 0 3000 300 230 18 0 180 263 18 56 259 54 277 134 258 271 150 328 7917 64850 83607 64283 28990 56987 10717 64225 51374 64400 55745 23299 23647 23439 79370 80823 339416728113 0 0 79 78 127124124872 0 0 16 74 16 283171 74 0 59 55 158798 0154796 149 0 148 62 59 340895 0 4q25 4q21 2q21 1p21 Xq24 Xq23 Xq24 Xq23 11p15 11p13 100131378 0 1q32.1 1q25.1 5q13.2 3q21.3 1q32.2 3q13.1 1p13.3 1p13.2 2p22.3 2p23.3 6p21.3 10q25.2 16q12.2 14q22.2 14q11.2 9q22.32 11q24.3 11q13.2 100505621 0 10q11.22 17q21.33 10p12.31 12p13-p12 1p32.3-p31.3 81573 16p12.2-p12.1 55114 alpha 2A adrenoceptor 2-like 1 alanine-glyoxylate aminotransferase A kinase 14 (PRKA) anchor protein AKT protein interacting ameloblastin (enamel matrix protein) AMMECR1-like angiomotin deaminase 2 adenosine monophosphate alpha 1B (salivary) amylase, ankyrin domain 13C repeat ankyrin domain 45 repeat A8-like 1 annexin 4, beta 1 subunit complex protein adaptor-related 5, mu 1 subunit complex protein adaptor-related APEX nuclease (multifunctional ) DNA repair 1 2 factor protein interacting ADP-ribosylation 17 activating protein Rho GTPase 28 factor (GEF) Rho guanine nucleotide exchange homolog 1 (Drosophila) asteroid 2 GTPase atlastin Na+/K+ transporting, beta 4 polypeptide ATPase, V1 subunit G3 13kDa, H+ transporting, lysosomal ATPase, factor differentiation acid-induced retinoic all-trans 2 beta-1,4-N-acetyl-galactosaminyl transferase 6 athanogene BCL2-associated homolog (Drosophila) sox bobby facilitator) BCL2-like 14 (apoptosis 9 class B, basic helix-loop-helix domain containing, bicaudal D homolog 2 (Drosophila) 112 frame 10 open reading chromosome 44 frame 11 open reading chromosome 72 frame 11 open reading chromosome 91 frame 11 open reading chromosome BBX ATL2 BAG6 AKTIP BICD2 AMOT ASTE1 AMBN APEX1 AP4B1 ARFIP2 AP5M1 AMY1B ATRAID ATP1B4 AMPD2 AKAP14 BHLHB9 ADRA2A BCL2L14 ADORA1 AGXT2L1 C11orf44 C11orf72 C11orf91 ANXA8L1 ANKRD45 ATP6V1G3 C10orf112 B4GALNT2 ARHGEF28 ARHGAP17 ANKRD13C AMMECR1L CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

190 Translational Neuroscience 0 0 0 0 0 1 0 0 0 2 1 0 0 0 0 2 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 2 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 119 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 12 12 11 11 72 72 122 0 100 10 0 000 45 588 18 45 586 18 0 0 0 0 19 18 00 10 10 0 617 617 00 3521 3521 0 660 64 00 16 434 504 16 420 502 0 0 56 56 732 805 783 9398 8556 4064 4179 1063 1952 84520 56683 56882 56990 55755 55573 79635 51244 79080 79587 80323 83692 148304 0 646019643677 0 0 729440159989 0 0 645121 0 400757 0339778388960 63 0 0 414919 62 0 203238728621 0 0 531 531 8q24 5q12 1q32 1q41 1p13 1p21 Xq28 13q34 11q21 18q21 10p12 1q32.2 6q25.3 100130967 0 5q35.3 5q31.1 1q21.1 5q31.1 9q33.3 3q22.1 1p31.2 2p23.3 2p13.2 1p32.2 2p23.2 9p22.2 3p25.1 1p34.2 1p13.3 13q33.1 11q12.2 14q32.12 21q22.11 19q13.32 2p21.3-p21.1 chromosome 14 open reading frame 142 frame 14 open reading chromosome 141 frame 1 open reading chromosome 74 frame 1 open reading chromosome 59 frame 21 open reading chromosome 70 frame 2 open reading chromosome 78 frame 2 open reading chromosome 99 frame 6 open reading , beta polypeptide component complement 82 frame 8 open reading chromosome voltage-dependent,calcium channel, beta 2 subunit calmodulin 2 (phosphorylase kinase, delta) (putative) 2, mitochondrial synthetase cysteinyl-tRNA homolog 3 (Drosophila) chibby 121 coiled-coil domain containing 168 coiled-coil domain containing 171 coiled-coil domain containing 174 coiled-coil domain containing 30 coiled-coil domain containing 61 coiled-coil domain containing 67 coiled-coil domain containing 68 coiled-coil domain containing 86 coiled-coil domain containing member 2 cyclin I family, CD101 molecule CD180 molecule regulatory protein complement CD46 molecule, CD99 molecule-like 2 division cyclecell 14A 1 CDC42 small effector 2 CDC42 small effector 2 protein CDK5 regulatory subunit associated CDV3 homolog (mouse) 2 G-type receptor seven-pass cadherin, EGF LAG 350/400kDa F, protein centromere C8B CBY3 CD46 CDV3 CCNI2 CARS2 CENPF CD101 CD180 CALM2 CELSR2 CD99L2 C1orf74 C2orf70 C2orf78 C6orf99 C8orf82 CCDC30 CCDC61 CCDC67 CCDC68 CCDC86 CACNB2 CDC14A C1orf141 C21orf59 CCDC121 CCDC168 CCDC171 CCDC174 C14orf142 CDC42SE1 CDC42SE2 CDK5RAP2 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

191 Translational Neuroscience 0 0 0 0 1 0 1 0 1 0 0 1 0 0 2 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 8 0 0 0 1 0 0 0 17 26 2 8 0 0 0 1 0 0 0 12 12 12 12 27 21 21 11 11 0 150 15 240 24 33 33 0 0 84 83 00 24 61 24 60 0 0 1640 164 0 39 38 00 440 44 26 26 00 0 1260 126 18 0 940 680 94 142 680 142 00 96 94 0 436 436 0 54 53 0 0 1300 1347 1434 4253 8451 1716 8110 9731 1736 26097 22796 10212 83479 23549 29940 55894 90957 11080 51277 55165 79145 23562 57511 51635 30848 116173728577 0 0 340665339761 0 0 45 45 548645 0 388753 0 324 323 374387 0 6q22 9p12 2p13 Xq28 Xq28 20q13 13q34 1q21.3 1q42.2 6q14.1 2q14.3 1q32.1 9q31.3 2q36.1 8p23.1 2p22.3 1p31.1 2p23.3 10q24.1 8q11.23 14q23.321q22.3 14q11.2 100529261 0 13q13.2 14q21.1 14q23.1 14q24.2 1p36.32 11p11.2 10q23.33 19p13.12 6q21-q22 2p12-p11.2 26505 centrosomal protein 104kDa protein centrosomal 55kDa protein centrosomal coiled-coil-helix-coiled-coil-helix 7 domain containing of PRMT1 target chromatin CHURC1-FNTB readthrough claudin 14 5 domain containing CKLF-like MARVEL transmembrane cyclin M3 3B protein-like contactin associated assembly factor 6 homolog (S. cerevisiae)cytochrome c oxidase 2 complex of oligomeric golgi component 6 complex of oligomeric golgi component 1q42.2 typecollagen, X, alpha 1 VIIa polypeptide 2 (liver) subunit cytochrome c oxidase 1-like (yeast) segregation CSE1 antigen cancer/testis member 5 family, CTAGE cullin 4A cytochrome P450, family 26, subfamily C, polypeptide 1 cytochrome P450, family 27, subfamily C, polypeptide 1 polypeptide 39A box DEAD (Asp-Glu-Ala-Asp) polypeptide 59 box DEAD (Asp-Glu-Ala-Asp) beta 103B defensin, kinasedeoxyguanosine (SDR family) member 7 dehydrogenase/reductase polypeptide 57 DEAH (Asp-Glu-Ala-Asp/His) box 1, dyskerin congenita dyskeratosis DKFZp779M0652 uncharacterized member 4 subfamily B, DnaJ (Hsp40) homolog, subfamily C, member 25 DnaJ (Hsp40) homolog, subfamily C, member 27 DnaJ (Hsp40) homolog, aspartyl aminopeptidase family 3 D4, zinc and double PHD fingers, epimerase dermatan sulfate DSE DPF3 DKC1 COA6 COG2 COG6 CSE1L CEP55 CTAG2 CUL4A DHRS7 DNPEP DHX57 DDX59 CHTOP CEP104 DGUOK CMTM5 CNNM3 CTAGE5 DNAJB4 COX7A2 CLDN14 DDX39A CHCHD7 CYP26C1 CYP27C1 COL10A1 DNAJC25 DNAJC27 DEFB103B CNTNAP3B CHURC1-FNTB DKFZp779M0652 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

192 Translational Neuroscience 0 0 3 0 0 0 3 0 0 1 0 0 1 0 1 0 1 0 5 0 0 0 0 0 1 0 0 0 0 0 0 12 11 0 3 0 0 0 0 0 0 0 0 8 0 0 0 26 0 3 0 0 0 0 0 0 0 0 8 0 0 0 27 0 24200 0 239 479 479 0 3200 320 0 79 79 0 0 180 15 0 511 169 511 164 0 0 00 34790 66 3467 66 0 0 2877 2866 0 384 384 0 00 70 70 00 24 23 2029 2047 1896 2035 2253 3170 8891 2281 64834 90141 22936 11117 64097 11082 55719 84624 23071 84293 55731 23052 83641 54752 80164 253738 0 46 46 653316148753 0 0 105 104 121506 0 34399888 33 440585 0 0 642489158521 0 163479 0 0 49 32 48 32 5q15 5q11 6q12 6q25 1p34 Xq28 11q21 17q12 10p14 20p11 1q21.3 5q21.3 5q35.3 1q25.2 1p34.1 1p34.2 2p23.3 1p13.3 10q26.3 9q22.33 10q23.1 17q11.2 12p12.3 11p11.2 19p13.2 14q32.11 10q24.31 1p33-p32 3q21-q23 10q25-q26 Xq12-q13.1 2p23.3-p23.2 20q13.2-q13.3 1908 early B-cell factor 3 ectodysplasin A endothelin 3 EF-hand calcium binding domain 11 eukaryotic subunit 3 gamma, factor initiation 2B, translation 58kDa II, 2 RNA polymerase factor, elongation fatty acid elongase 1 ELOVL interfacerelastin microfibril 1 1 endonuclease domain containing endosulfine alpha erythrocyte band 4.1 (elliptocytosis 1, protein membrane RH-linked) erythrocyte band 4.1 like 4A protein membrane B1 EPH receptor 27 protein 44 protein endoplasmic reticulum molecule 1 endothelial cell-specific similarityfamily with sequence 107, member B similarityfamily with sequence 153, member C similarityfamily with sequence 163, member A similarityfamily with sequence 178, member A similarityfamily with sequence 180, member B similarityfamily with sequence 183, member A similarityfamily with sequence 213, member A similarityfamily with sequence 222, member B factor 8 (androgen-induced) growth fibroblast 12.6 kDa 1B, FK506 binding protein 1C FK506 binding protein FLJ22184 protein uncharacterized putative 1 neighbor retardation X mental fragile fibronectin 1 containing type III domain fibronectin 7 containing type III domain fibronectin 8 containing type III domain A2 forkhead box EDA ELL2 EBF3 FGF8 ENSA ESM1 EDN3 EPB41 ERP27 ERP44 EPHB1 EIF2B3 FOXA2 FNDC1 FNDC7 FNDC8 ELOVL1 FKBP1B FKBP1C EMILIN1 FMR1NB ENDOD1 EFCAB11 FLJ22184 FAM107B FAM180B FAM222B FAM153C FAM163A FAM178A FAM183A FAM213A EPB41L4A CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

193 Translational Neuroscience 1 0 0 3 1 0 0 1 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 4 1 5 0 0 1 0 0 0 0 0 0 0 0 0 0 0 16 3 0 0 0 0 0 0 0 0 0 0 17 71 71 12 12 17 17 21 21 0 0 255 254 0 0 0 460 46 0 0 188 188 00 160 160 14 13 00 90 90 00 0 37 37 000 311 57 311 57 0 0 0 4250 425 0 2650 264 0 265 264 2705 2741 2888 9446 3218 9630 8443 2842 8880 1647 2635 8329 3206 10691 51301 83445 79713 79885 64645 80201 55559 55869 64344 51125 150763440435 0 0 13 13 143279 0 135 131 349334391059 0 0 95 93 165082 0 283120 0 239 238 204851 0 134 129 9q13 5q12 9q21 1q42 1p35 Xq28 Xq13 19q13 5q33.1 2q11.2 1p21.3 1p31.1 1p31.2 1p22.2 2p24.1 3p25.1 1p21.3 1p13.1 6p22.1 7p15.2 Xq13.1 17q21.1 10q25.1 10q22.1 8p11.21 12p12.3 11p15.5 10q23.32 17q21.32 19q13.12 12p13.31 2q22-q24 19q11-q13.2 3249 forkhead box D4-like 4 forkhead box ferric-chelate reductase 1 1 (FUSE) binding protein element far upstream and DNA-damage-inducible, arrest growth alpha 3 binding protein guanylate 2 4, core (N-acetyl) transferase glucosaminyl beta 1, 32kDa gap junction protein, alpha 1 receptor, glycine glucocorticoid 1 modulatory binding protein element alpha 14 protein), (G guanine nucleotide binding protein O-acyltransferase glyceronephosphate A7 golgin 2, mitochondrial acyltransferase glycerol-3-phosphate 113 receptor G protein-coupled 179 receptor G protein-coupled 19 receptor G protein-coupled 14 protein factor receptor-bound growth 1 associated germ cell omega 1 S-transferase glutathione (non-protein transcript expressed maternally H19, imprinted coding) subunit 7 complex, augmin-like HAUS deacetylase 11 histone deacetylase 8 histone HECT ligase 2 E3 ubiquitin protein domain containing 1 transcript hippocampus abundant inducible factor 3, alpha subunit hypoxia kinase protein 1 homeodomain interacting 1, H2ai cluster histone 1 domain containing hexokinase A10 homeobox B8 homeobox hepsin 1 IGF-like family receptor H19 HPN GJB1 GBP3 GSG1 HIAT1 HIPK1 HIF3A FRRS1 GPAT2 FUBP1 GPR19 GRB14 GLRA1 GNPAT GSTO1 HAUS7 GCNT4 IGFLR1 GNA14 HOXB8 HKDC1 HDAC8 GMEB1 GPR113 GPR179 HECTD2 HOXA10 HDAC11 GOLGA7 FOXD4L4 GADD45A HIST1H2AI CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

194 Translational Neuroscience 2 0 0 2 0 1 0 8 1 0 3 2 0 5 1 0 1 0 0 0 0 0 0 3 0 0 1 1 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 718 276 4 0 0 0 0 0 0 0 0 0 11 11 21 21 12 12 721 272 272 277 0 0 58 56 0 67 67 0 0 0 0 000 26 1420 50 26 142 49 0 0 27000 269 0 310 34 30 0 310 34 46 28 0 0 44 0 190 18 89 89 3497 3611 3630 9358 3735 3835 3800 3824 3948 11009 58493 11127 27190 26034 10265 23522 64376 30819 79831 57613 64147 126298 0 133396 0 101 101 389434 0 46154288 38 0 128209112849 0389541160287 0 42 0 0 37 49 48 440073 0 1q32 9q32 6q13 5q31 2q23 10q26 13q33 10q24 12p13 5q33.1 5q11.2 6q25.2 6q25.1 1p34.1 16q12.2 16q23.1 10q22.2 14q23.1 11p15.4 11p15.5 16p12.1 12p13.1 16p11.2 3p21.31 11p15.1 11p15.1 14q32.33 19q13.31 12p13.33 7p15.2-p15.1 221895 0 527 526 18q11.2-q12.1 55364 Xq28 and Yq12 and Xq28 3581 immunoglobulin heavy constant epsilon immunoglobulin heavy constant IKAROS family zinc finger 5 (Pegasus) interleukin 17B interleukin 24 A interleukin 31 receptor interleukin 9 receptor kinaseintegrin-linked impact RWD domain protein protein and NABP interacting INTS3 insulin factors cytohesin 1 exchange for protein interaction IQ motif and Sec7 domain 3 Q family, GTPase immunity-related 5 homeobox iroquois domains) beta-like 1 (with EGF-like repeat integrin, deiodinase iodotyrosine JAZF zinc finger 1 synthetase lysyl-tRNA 6B acetyltransferase K(lysine) 2 protein channel interacting Kv (K)-specificlysine 8 demethylase subcortical 3-like, complex maternal KH domain containing member KIAA1467 kinesin family member 22 kinesin family member 3A kinesin family member 5C kinesin family member 9 Kruppel-like factor 17 member 1 killer subfamily D, lectin-like cell receptor (trans-) dehydratase L-3-hydroxyproline 4 activator and MTOR MAPK adaptor, endosomal/lysosomal late 6A A-like lactate dehydrogenase C lactate dehydrogenase 7q22 ILK INS IYD INIP IL24 IL9R KIF9 IRX5 IGHE IRGQ KARS IL17B KIF22 IKZF5 KIF5C LDHC KIF3A KLF17 JAZF1 KDM8 KAT6B KLRD1 IPCEF1 IL31RA ITGBL1 IQSEC3 KCNIP2 IMPACT KHDC3L LDHAL6A KIAA1467 L3HYPDH LAMTOR4 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

195 Translational Neuroscience 0 0 1 0 5 1 0 0 0 0 0 2 0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 0 5 0 3 7 13 0 8 0 3 0 0 0 3 20 16 77 120 177 717 0 8 0 3 0 0 0 3 21 17 12 17 22 22 17 17 122 00 1400 167 14 0 93 167 90 93 90 0 2490 236 0 0 0 0 118 118 0 0 0 38 38 0 40 40 0 0 640 64 4700 465 00 520 190 52 50 19 48 0 180 0 490 49 724 8569 4686 4105 4249 4582 4595 4678 11222 54516 23148 55679 55788 25802 55379 10446 79840 64175 55892 29104 10046 79133 51199 134353 0 13 13 149013 0 340527 0 115004728464388931 0 0 0 78 729967 0 13 13 6q13 6q13 6q21 2q21 1q22 2q35 1p33 7p13 Xq28 Xq28 2q21.1 1q32.1 1q32.1 5q33.3 1q21.1 9q34.1 1p34.1 2p23.3 2p22.1 1p34.1 1p34.1 Xq13.1 3q26.31 21q21.3 20p12.1 17q21.33 3q21-q23 6q25-q26 14q21-q22 18q21.3-q22 3998 17q21.3-q2221q11.2-q21 51264 11q12-q13.1 54148 9219 leucine proline-enriched 1 (leprecan) proteoglycan domains 2 antigen-like cell LIM and senescent lectin, mannose-binding, 1 1 LMBR1 domain containing leiomodin 1 () 59 containing leucine rich repeat 2 neuronal leucine rich repeat LSM11, U7 small nuclear RNA associated family A, 6 melanoma antigen 1 domain containing mastermind-like Mab-21 1 domain containing like 24 methyltransferase superfamilymajor facilitator 2B domain containing beta-1,6-N-acetyl- mannosyl (alpha-1,6-)-glycoprotein glucosaminyltransferase kinase kinaseMAP serine/threonine interacting 1 2 containing MORN repeat L27 ribosomalmitochondrial protein L3 ribosomalmitochondrial protein L39 ribosomalmitochondrial protein member 2 1 family, metastasis associated factor 1-like release translational mitochondrial surfacemucin 1, cell associated coli) mutY homolog (E. myoneurin 1 (putative) N-6 adenine-specific DNA methyltransferase alpha domain containing NAC (histone-binding) sperm protein nuclear autoantigenic member 12 breakpoint family, neuroblastoma subunit 1, 80kDa nuclear cap binding protein I, assembly factor (ubiquinone) complex NADH dehydrogenase 5 nonhomologous end-joining factor 1 NHS-like 2 protein) interacting (GSK3B NIN NASP MTA2 LIMS2 MUC1 MYNN NHEJ1 LRRN2 NHSL2 LSM11 NCBP1 MRPL3 MGAT5 LEPRE1 LMAN1 MKNK1 NACAD LMOD1 LRRC59 MUTYH MORN2 NBPF12 MTRF1L MRPL27 MRPL39 MFSD2B LMBRD1 MB21D1 N6AMT1 MAGEA6 METTL24 MAMLD1 NDUFAF5 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

196 Translational Neuroscience 1 0 0 0 1 0 1 6 0 0 1 0 0 0 1 0 2 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 8 1 0 0 0 7 0 0 0 0 2 0 0 0 0 0 0 0 2 0 11 11 11 11 00 0 44 43 0 19 19 00 44 44 0 66 65 0 0 0 944 944 00 2200 219 0 53 53 0 0 110 110 5018 27031 10360 29959 58505 27065 28989 91775 26735 26248 26031 56001 54827 55916 79991 64081 389643348995 0 0 55222950 49 282770 0 391107128360 0 138803 0 392392 0 0 120775 0 219986 0 256892390072 0 219438 0 390162 0 114884 0 114876 0 0 0152559 936 0 936 3q22 4q25 4q21 2p23 3p23 11q11 11q11 11q11 9q34.2 6q25.1 3q12.3 7q22.1 1q23.1 1q23.1 9q31.1 9q33.2 9q33.2 9q31.3 4p16.3 8p21.1 7p15.3 Xq22.1 Xq22.3 11q23.3 10q25.1 11q12.1 18q11.2 14q11.2 10q21.3 11p15.4 11p15.4 11p15.4 10q24.31 nephronophthisis 3 (adolescent) nephronophthisis nucleophosmin/nucleoplasmin 3 1 binding protein nuclear receptor specific gene family member 1 neuron 1 N-methyltransferase Xaa-Pro-Lys N-terminal associated germinal center nuclear GTPase, nucleoporin 43kDa nuclear RNA export factor 2 member 3 and PC-esterase domain family, neurexophilin member 4 and PC-esterase domain family, neurexophilin nuclear transport factor 2-like export factor 2 tyrosine-phosphorylatedneuronal phosphoinositide-3-kinase 1 adaptor oligonucleotide/oligosaccharide-binding 1 containing fold member 1 family 10, subfamily AG, olfactory receptor, family 10, subfamily K, member 2 olfactory receptor, member 2 T, family 10, subfamily olfactory receptor, family 13, subfamily C, member 3 olfactory receptor, family 1, subfamily K, member 1 olfactory receptor, family 1, subfamily L, member 3 olfactory receptor, member 3 family 2, subfamily D, olfactory receptor, family 2, subfamily K, member 2 olfactory receptor, member 11 family 4, subfamily D, olfactory receptor, member 1 family 51, subfamily F, olfactory receptor, family 52, subfamily N, member 4 olfactory receptor, member 18 family 5, subfamily D, olfactory receptor, family 5, subfamily M, member 9 olfactory receptor, 10 binding protein-like oxysterol 1A binding protein-like oxysterol 3 binding protein-like oxysterol subunit (non-catalytic) complex oligosaccharyltransferase (cytochrome c) assembly 1-like oxidase family member III and adipoQ receptor progestin domain containing protein phenazine biosynthesis-like NXF2 PBLD NXT2 OSTC NSG1 NPM3 OR1L3 NXPE3 NXPE4 NYAP1 OXA1L NRBP1 PAQR3 OR1K1 OR2K2 OBFC1 NUP43 NPHP3 OR2D3 NTMT1 OR5M9 NUGGC OSBPL3 OR51F1 OR10T2 OR10K2 OR13C3 OR52N4 OR4D11 OR5D18 OSBPL10 OSBPL1A OR10AG1 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

197 Translational Neuroscience 0 0 0 0 1 0 0 0 0 0 0 0 0 0 6 0 0 2 1 0 0 1 4 0 1 1 5 0 0 0 0 4 0 0 7 0 5 0 3 7 0 0 0 4 12 167 0 7 0 6 0 4 8 0 0 0 8 17 17 12 12 172 0 0 14 14 0 36 36 0 115 115 0 19 19 0 65 65 0 0 145 145 0 00 290 2660 29 262 0 480 48 0 0 00 638 46 638 0 46 00 18 000 15 60 76 15 0 58 0 75 0 40 131 40 131 8654 5208 5298 5328 5468 5516 5549 5691 5711 9491 5453 5052 8643 5737 27039 23082 29942 10954 63895 23129 84279 23215 84722 23481 50487 79057 55795 442862 0 50118672 50 0 128344 0 653619 0 4q27 1q21 5q31 1q32 3p25 8p12 8p11 Xq28 13q34 10q24 17q12 20p13 3q21.1 3q21.3 1q24.3 1p13.2 1p34.3 2p13.2 1p34.1 1p13.3 1p34.1 1p31.1 22q12.1 22q12.2 1p36.21 Yq11.223 10q24.32 10q26.13 18p11.21 1q31-q32.2 11q12-q13.3 11251 20q13.32-q13.33 116154 0 695 694 PCI domain containing 2 PCI domain containing 5A, cGMP-specific phosphodiesterase family A, member 5 disulfide isomerase protein pescadillo ribosomal biogenesis factor 1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 3 and actinphosphatase regulator beta 4-kinase, catalytic, phosphatidylinositol 2 piezo-type ion channel component mechanosensitive primary cilia formation polycystic kidney disease 2-like 2 III phospholipase A2, group , D1 plexin 1 POU class 3 homeobox gamma receptor proliferator-activated peroxisome beta isozyme subunit, 2, catalytic phosphatase protein gamma, receptor proliferator-activated peroxisome 1 coactivator-related 1 protease-associated domain containing PRAME family member 15 1 peroxiredoxin proline/arginine-rich end leucine-rich protein repeat proline-rich coiled-coil 2C rich Gla (G-carboxyglutamic acid) 3 (transmembrane) proline 2 Y-linked PTPN13-like, 3 beta type, subunit, macropain) (prosome, proteasome 5 non-ATPase, 26S subunit, macropain) (prosome, proteasome subunit 1 (PI31) inhibitor macropain) (prosome, proteasome proline/serine-rich coiled-coil 1 9q34.11 phosphoseryl-tRNA kinase 2 patched 2 D2 receptor prostaglandin (FP) F receptor prostaglandin purine-rich G binding protein element PIFO PES1 PSTK PRY2 PLAU PI4KB PURG PCID2 PDIA5 PRELP PSRC1 PTGFR PPRC1 PTCH2 PPARG PRRG3 PRDX1 PDE5A PSMF1 PSMB3 PIEZO2 PSMD5 PFKFB2 PPP2CB PKD2L2 PLA2G3 PRRC2C PLXND1 PTGDR2 POU3F1 PRADC1 PHACTR3 PRAMEF15 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

198 Translational Neuroscience 0 0 0 1 0 8 0 0 0 0 2 2 0 0 1 0 1 0 4 0 0 5 0 1 1 2 0 3 0 7 6 0 0 0 4 0 0 0 0 4 0 6 0 0 4 27 0 4 0 0 0 0 5 0 9 0 0 4 0 2980 290 00 26 65 26 65 00 14 390 14 390 0 1570 155 0 35 34 00 95 95 0 4460 441 0 6650 0 664 80 428 80 426 00 133 126 33 31 00 0 600 594 33 33 0 000 83 62 31 82 62 5817 9462 6118 6251 6906 9869 1104 6125 9122 10111 55544 64121 51018 10067 22955 80135 23212 83861 57147 10802 55285 27316 57167 55423 388531440804 0 0 253959 0 844389075 844 317671 0 0 134701 0 284904 0 33 32 1q25 2q35 5q15 1q41 1q21 1q21 1p35 1p34 1p34 Xq26 10p13 20p13 4q22.1 100996939 0 6q14.2 8q12.3 6q25.3 1q24.2 5q31.1 1p35.3 1p22.3 1p22.1 1p13.3 Xq22.3 19q13.2 14q13.2 20q13.2 22q12.1 20q13.31 19q13.11 22q11.21 5q23-q31 Xq21-q22 11p15.1-p14 6289 poliovirus receptor poliovirus frame reading PIGY upstream RAD50 homolog (S. cerevisiae) alpha subunit 1 (catalytic) activating protein, Ral GTPase like 2 activator RAS protein 38 RNA binding motif protein 41 RNA binding motif protein X-linked RNA binding motif protein, 1 condensation of chromosome regulator endocrine-specific 18 regulated protein Rieske domain containing (Fe-S) 9 binding protein signaling of G protein regulator 3B RIMS binding protein ripply2 homolog () A2, 32kDa protein replication ribosome production factor 1 homolog (S. cerevisiae) L5 ribosomal protein GTP binding C Ras-related 15 homolog (S. cerevisiae) ribosomal RNA processing homolog (S. cerevisiae) RRS1 ribosome biogenesis regulator spoke 3 homolog (Chlamydomonas) radial 1 Ras protein suppressor A2 serum amyloid sal-like 4 (Drosophila) 3 secretory carrier protein membrane on midleg homolog 1 (Drosophila) comb sex SCY1-like 3 (S. cerevisiae) SEC14-like 4 (S. cerevisiae) member A (S. cerevisiae) SEC24 family, clade A (alpha-1 antiproteinase, serpin peptidase inhibitor, antitrypsin), member 7 1 SET domain, bifurcated gamma protein signal-regulatory carriersolute family 16, member 4 (monocarboxylic acid transporter 5) PVR RPL5 RPF1 RRS1 RPA2 SAA2 RSU1 RCC1 RBMX SIRPG SALL4 SCYL3 RRP15 RFESD RSPH3 PYURF RAD50 RRAGC RBM38 RBM41 SCMH1 RESP18 SEC24A RASAL2 SETDB1 RIPPLY2 RGS9BP SCAMP3 SEC14L4 SLC16A4 RIMBP3B SERPINA7 RALGAPA1 CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

199 Translational Neuroscience 0 0 0 0 0 1 0 0 2 8 0 0 0 1 0 0 0 0 4 1 0 1 0 0 4 0 0 0 0 0 15 30 0 0 1 0 0 7 6 0 1221 0 0 2 0 0 7 6 0 11 11 0 81 81 00 1230 58 123 58 0 0 48 48 0 370 37 0 34 33 0 0 00 48 46 48 0 44 0 126 1229 125 00 210 210 00 179 175 44 44 0 385 370 00 880 509 88 2040 509 2010 0 540 54 0 280 28 0 59 55 0 709 709 6526 6525 6632 6672 6671 8867 6867 6886 6520 6658 9295 6884 10322 28965 23315 23380 26123 10568 54716 56910 27285 83874 79101 50836 10178 55553 402055 0 13 13 151295 0 15 14 408187 0 2q35 5q32 2p12 7p15 8p11 1p32 Xq27 Xq25 22q12 11q21 12p13 5q23.3 2q37.1 1q32.1 4p15.2 3p21.6 1p31.1 2p11.1 1p13.3 1p34.3 18q11.2 22q12.1 21q22.2 22q12.2 11p15.3 21q22.11 20q13.13 10q23.33 11q12-q22 17q21.3-q22 6668 1p35.3-p34.1 64744 5q11.2-q13.1 6880 solute carriersolute family 23 (nucleobase transporters), member 3 carriersolute family 27 (fatty acid transporter), member 6 member 2 carriersolute family 34 (sodium phosphate), carrier amino solute of dibasic and neutral family 3 (activators acid transport), member 2 cotransporter), carrier solute family 5 (sodium/myo-inositol member 3 IMINO transporter), carriersolute family 6 (proline member 20 carrier proton solute family 9, subfamily A (NHE8, cation antiporter 8), member 8 small ArfGAP2 smoothelin family member 5 SMYD D1 polypeptide 16kDa small nuclear ribonucleoprotein Y)-box 3 region determining (sex SRY Y)-box 6 region determining (sex SRY SP100 nuclear antigen factorSp2 transcription factorSp4 transcription Kazal type 14 (putative) serine peptidase inhibitor, 2 activating protein Rho GTPase SLIT-ROBO SRR1 domain containing serine/arginine-rich splicing factor 11 7 domain containing (START) transfer StAR-related 1 synaptojanin 1 protein acidic coiled-coil containing transforming, (TBP)- binding protein box TATA II, RNA polymerase TAF13 18kDa factor, associated RNA (TBP)-associated binding protein box factor, TATA 41kDa I, D, polymerase (TBP)- binding protein box TATA II, RNA polymerase TAF9 32kDa factor, associated lymphocytic acute leukemia 1 T-cell type 2, member 8 receptor, taste member 10A TBC1 domain family, tectonic family member 3 2 (testicular) tektin 1 protein transmembrane teneurin SP2 SP4 TAL1 TAF9 SOX3 SOX6 SRRD SMTN TEKT2 TAF13 SP100 SYNJ1 TACC1 TAF1D TCTN3 SMAP2 TENM1 SMYD5 SRSF11 TAS2R8 SLC3A2 SLC5A3 SLC9A8 STARD7 SRGAP2 SNRPD1 SPINK14 SLC23A3 SLC27A6 SLC34A2 SLC6A20 TBC1D10A CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

200 Translational Neuroscience 0 0 1 0 0 0 0 2 0 1 0 0 2 2 2 1 0 0 0 0 1 3 0 1 0 0 0 0 0 0 0 1 0 0 8 5 8 7 0 0 0 5 1 0 2 0 0 0 1 0 76 17 8 5 8 8 0 0 0 5 2 3 3 0 0 0 1 0 77 12 12 00 78 376 78 376 0 0 0 54 54 0 0 0 00 30 30 0 0 47 47 00 26 24 0 330 330 0 43 42 0 00 56 302 54 302 0 0 0 19 0 83 81 0 125 125 7073 9911 8460 7136 7140 7188 7324 55260 81615 80128 81027 79876 55258 80263 54952 54386 93081 80195 85025 54777 90655 84187 57146 91978 387718 0 653252 0 259236 0 114034 0 114088115708 0728395 0 125488 251 0 0 250 206 206 129293 0 10q 1q32 1q22 3q22 3p21 1p33 14q32 1q32.1 2q21.3 2p11.2 2p11.2 1p13.1 1p35.3 3p24.2 Yp11.2 Yp11.2 Xq22.3 16q23.1 13q33.1 10q23.1 7q11.23 7q11.21 14q21.3 18q11.2 10q26.3 16p12.2 11p15.5 11p15.5 19p13.3 10q26.13 10q11.23 19q13.32 20q13.32 14q23.3-q24.1 161145 0 123 123 telomeric repeat binding factor protein 2, interacting repeat telomeric 30 expressed testis 36 expressed testis Y-linked 2-like, factor homeobox TGFB-induced synthase-likethreonine 2 (S. cerevisiae) 1 granule-associated RNA binding protein-like TIA1 cytotoxic 23 homolog B membrane of inner mitochondrial (yeast) and coiled-coil domain family 2 transmembrane 143 protein transmembrane 159 protein transmembrane 163 protein transmembrane 164 protein transmembrane 229B protein transmembrane 254 protein transmembrane 60 protein transmembrane inner ear transmembrane fast) I type 2 (skeletal, fast) T type 3 (skeletal, troponin of EGR1, member 1 (nuclear) target subunit 1 complex tubulin polyglutamylase 1 sulfotransferase tyrosylprotein 2A domain containing TraB factor 5 TNF receptor-associated tripartite 45 motif containing tripartite 46 motif containing tripartite 9 motif containing 61 homolog A (S. cerevisiae) tRNA methyltransferase 1 protein tRNA selenocysteine 1 associated Y-linked 4 specific protein, testis domain 39C repeat tetratricopeptide domain 40 repeat tetratricopeptide VI tubulin, beta 1 class ubiquitin-like modifier activating enzyme 5 ubiquitin-conjugating enzyme E2E 1 TMIE TOE1 UBA5 TIAL1 TPST1 TEX30 TEX36 TSPY4 TNNI2 TRIM9 TTC40 TRAF5 TPGS1 TUBB1 TNNT3 TMCC2 TRIM45 TRIM46 UBE2E1 TTC39C THNSL2 TGIF2LY TERF2IP TMEM60 TIMM23B TRABD2A TRMT61A TMEM143 TMEM159 TMEM163 TMEM164 TMEM254 TRNAU1AP TMEM229B CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

201 Translational Neuroscience 0 0 0 3 0 3 4 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 8 0 0 0 1 2 0 3 0 6 0 0 0 0 3 4 1 3 0 4 0 7 0 0 0 0 00 41 41 0 660 66 0 30 30 00 950 92 0 0 0 178 178 0 109 109 0 00 429 429 0 19 19 0 0 5500 55 50 181 50 0 181 188 188 0 000 560 620 56 0 489 62 33 139 489 33 131 9559 9213 7517 7764 7411 7545 7701 7566 5212 79805 11023 54838 54554 91746 90075 57592 51123 23160 79693 26009 55062 50613 54521 10009 51114 10083 51304 79698 146862 0 81 81 199704 0 39 39 441234 0 1q23 3q24 2q35 Xq28 Xq24 Xq23 17q12 11p15 17p12 3q21.1 1q25.1 4q13.3 1q21.2 8q22.3 2p22.2 2p23.3 1p34.3 7p11.1 1p31.1 Xq26.1 10q21.1 17q24.2 14q32.3 20q13.2 11p14.3 3p21.31 8p11.21 10q26.11 10q24.33 19q13.13 19q13.13 ubiquilin 3 elegans) unc-45 homolog B (C. severe) recessive, 1C (autosomal syndrome Usher 2 vasohibin 1 homeobox anterior ventral 1 Hippel-Lindau von binding protein vitrin sorting protein vacuolar 26 homolog A (S. pombe) 1-like WW domain binding protein domain 43 WD repeat domain 44 WD repeat domain 5B WD repeat 1 domain, phosphoinositide interacting WD repeat 1 receptor retrovirus and polytropic xenotropic in Chinese repair defective complementing repair X-ray 3 cells hamster coli) (E. domain containing yrdC YTH 1 domain containing 33 containing BTB domain zinc finger and 3 DHHC-typecontaining zinc finger, 9 DHHC-typecontaining zinc finger, Zic family member 1 matrin-type 4 zinc finger, 142 zinc finger protein 18 zinc finger protein 217 zinc finger protein 30 zinc finger protein 585A zinc finger protein 687 zinc finger protein 706 zinc finger protein 716 zinc finger protein 3 containing ZZ-type zinc finger, VIT ZIC1 XPR1 VBP1 ZZZ3 VAX1 YRDC WIPI1 ZNF18 ZNF30 XRCC3 VASH2 USH1C ZMAT4 WBP1L WDR43 WDR44 ZBTB33 WDR5B VPS26A ZNF142 ZNF217 ZNF687 ZNF706 ZNF716 UNC45B YTHDC1 UBQLN3 ZDHHC3 ZDHHC9 ZNF585A CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL CONTROL

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