SUPPLEMENTARY MATERIALS and METHODS PBMC Transcriptomics

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BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Gut

SUPPLEMENTARY MATERIALS AND METHODS

PBMC transcriptomics identifies immune-metabolism disorder during the development

of HBV-ACLF

Contents

l Supplementary methods

l Supplementary Figure 1

l Supplementary Figure 2

l Supplementary Figure 3

l Supplementary Figure 4

l Supplementary Figure 5

l Supplementary Table 1

l Supplementary Table 2

l Supplementary Table 3

l Supplementary Table 4

l Supplementary Tables 5-14

l Supplementary Table 15

l Supplementary Table 16

l Supplementary Table 17

Li J, et al. Gut 2021;0:1–13. doi: 10.1136/gutjnl-2020-323395 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Gut

SUPPLEMENTARY METHODS

Test for HBV DNA

The levels of HBV DNA were detected using real-time PCR with a COBAS®

AmpliPrep/COBAS® TaqMan 48 System (Roche, Basel, Switzerland) and HBV Test v2.0.

Criteria for diagnosing cirrhosis

Pathology The gold standard for the diagnosis of cirrhosis is a liver biopsy obtained through a

percutaneous or transjugular approach.1 Ultrasonography was performed 2-4 hours before

biopsy. Liver biopsy specimens were obtained by experienced physicians. Percutaneous

transthoracic puncture of the liver was performed according to the standard criteria. After

biopsy, patients were monitored in the hospital with periodic analyses of haematocrit and other

vital signs for 24 hours. Cirrhosis was diagnosed according to the globally agreed upon criteria.2

Cirrhosis is defined based on its pathological features under a microscope: (a) the presence of

parenchymal nodules, (b) differences in liver cell size and appearance, (c) fragmentation of the

biopsy specimen, (d) fibrous septa, and (d) an altered architecture and vascular relationships.

Depending on the size of the nodules, three macroscopic types have been defined: micronodular,

macronodular, and mixed cirrhosis.

Endoscopy Gastroscopy (endoscopic examination of the oesophagus, stomach, and duodenum)

was performed to exclude the possibility of oesophageal and gastric varices.

Radiology Ultrasound is routinely used to evaluate cirrhosis.3 The liver size was calculated

from the longitudinal diameter of the right and left lobes and considered normal in the range of

9-14 cm and 7-10 cm, respectively.4 Liver morphology was based on the caudate/right lobe

ratio, as the former tends to be enlarged and the latter to shrink with the progression of cirrhosis.

This ratio was considered normal at a value less than 0.6.5 Liver boundaries were examined on

the inferior surface of the left and right lobes, particularly in relationship with the gallbladder

and right kidney, and were distinguished as normal, rounded and nodular.6 Liver echogenicity

was classified as normal, with increased reflectivity, and coarse and irregular in relation to the

echogenicity and the distribution of parenchymal echoes.7 Portal vein diameter was measured

as the largest anteroposterior diameter at the crossing point with the hepatic artery during

suspended respiration and considered normal at a value less than 12 mm.8 The mean flow

velocity of the portal vein was calculated using the pulsed Doppler technique9 after positioning

the sample volume at the cross point of the vein with the hepatic artery and considered normal

at values greater than 15 cm/s. Spleen size was assessed by the longitudinal cross-sectional area,

as this parameter has been reported to correlate with the actual spleen volume10 and is

considered normal at values up to 45 cm2. A small and nodular liver may be detected in patients

with advanced cirrhosis, along with increased echogenicity and irregularly appearing areas.

Other findings suggestive of cirrhosis in imaging are an enlarged caudate lobe, widening of the

liver fissures and enlargement of the spleen.

Other radiological tests include elastography techniques,11 abdominal CT and liver/bile duct

MRI (MRCP).

Sample preparation for mRNA sequencing

For mRNA-seq, PBMCs were collected from patients and volunteers using Ficoll-PaqueTM

PLUS medium (GE Healthcare, Uppsala, Sweden), and total RNA was extracted using TRIzol

reagent (Ambion, Carlsbad, CA). Sequencing libraries were prepared according to the

manufacturer’s instructions (TruSeq® RNA LT Sample Prep Kit v2, Illumina, San Diego, CA),

including purifying and fragmenting mRNA, synthesizing first-strand cDNAs, synthesizing

second-strand cDNAs, performing end repair by adenylating the 3' ends, ligating adapters, and

enriching DNA fragments. The pooled library consisted of sequences with lengths of

approximately 250 nucleotides. The library was sequenced using a HiSeq 2500 sequencing

system (Illumina).

qRT-PCR

qRT-PCR validation with samples from patients and experimental rats was performed to

confirm the results of the transcriptomic analysis. qRT-PCR was performed using a two-step

protocol with specific primers, TB Green DYE II (Takara, Beijing, China), and an ABI 7500HT

instrument (Thermo Fisher, Waltham, MA) according to the manufacturer’s instructions. The

amount of cDNA was optimized to ensure that the amplification of both control genes and

cDNAs of interest occurred in the exponential phase. Transcripts were quantified using the

comparative Ct method and normalized to the levels of the endogenous control (glyceraldehyde

phosphate dehydrogenase, GAPDH).

IHC

The expression of potential proteins encoded by the target genes were validated using IHC in

liver tissues derived from patients with HBV-ACLF and patients with LC (n=5/group)

according to a previously described protocol.12 Liver specimens were obtained from patients

with HBV-ACLF who received a liver transplant, while liver specimens were obtained from

patients with LC during biopsies. As a control, normal liver tissues were obtained from

therapeutic partial hepatectomies that were performed in patients with trauma-induced liver

rupture and who exhibited no signs of hepatic dysfunction, hepatitis virus (including A-E)

infection or hepatic cancer. Because the isolation of liver tissue samples from patients with

stable CHB and ACHD was difficult, IHC was not performed on samples from patients with

CHB and ACHD.

Experimental animals

SPF-grade male Sprague-Dawley rats (80 g body weight) were housed under controlled

environmental conditions (22±1°C, 55±5% relative humidity, 12 hour light–dark cycle) with

free access to food and water ad libitum. Animal care and all experimental procedures were

approved by the Animal Care Ethics Committee of the First Affiliated Hospital, Zhejiang

University, and conducted in accordance with the National Institute of Health (NIH) guidelines.

Establishment of the ACLF model

Rats were randomly allocated into two groups (control group: n=10; ACLF group: n=30). In

the ACLF group, rats were intraperitoneally administered porcine serum (Gibco, Grand Island,

NY, USA) at 2 mL/kg13 twice a week for 12 consecutive weeks to generate liver cirrhosis.

Afterwards, rats with liver cirrhosis were intraperitoneally injected with D-galactosamine (D-

Gal) and lipopolysaccharide (LPS) in combination (800 mg/kg D-Gal and 100 µg/kg LPS) to

induce acute liver failure based on chronic liver cirrhosis14, 15. Meanwhile, rats in the control

group were only administered normal saline. Animals were sacrificed at 0 and 48 hours, and

blood and tissue samples were collected.

Evaluation of biochemical function

Biochemical tests of liver function were evaluated by analysing 6 markers in rats in the control,

LC and ACLF groups using an automatic clinical chemistry analyser (AU5800, Beckman,

Jersey City, NJ, USA).

Haematoxylin-eosin (H&E) and Masson’s trichrome (M&T) staining

Liver tissues from the rat model of different stages of ACLF were collected for H&E and M&T

staining to observe the pathological features and progression of liver cirrhosis. Each liver tissue

section was heat-fixed at 60°C for 1 hour and then stained with H&E, as previously described.16

M&T staining was performed according to recommended protocols (Maixin Biotech, Fuzhou,

China and Solarbio LIFE SCIENCE, Beijing, China), as previously described.17

Identification of DEGs

Adaptors and low-quality reads were removed using Trimmomatic v0.36 with the default

parameters.18 Paired-end transcriptome sequencing reads from each sample were aligned with

a human reference genome (GRCh38.87) using HISAT v2.0.5 with the default parameters.19

StringTie v1.3.0 was used to assemble and quantify expressed genes and transcripts for each

sample and then merge the transcripts from all samples.20 PrepDE was used to compute the raw

read counts for each gene. Ballgown v2.6.0 was used to perform multigroup comparisons of

gene expression in fragments per kilobase per million.21 Low-variance genes were removed if

their expression variance was <1.0 across samples. Significance was defined as a q value <0.05,

i.e., a false discovery rate <5%. DESeq2 v1.14.1 was used to compare the transcriptomic

profiles between two groups and call DEGs using the Wald test.22 Low-abundance genes were

removed if their total expression was <1.0 in both groups or if their expression variance was

<1.0 across samples. Significance was defined as ‘P<0.05, adjusted P value <0.01’ in detecting

transcript changes, unless indicated otherwise. The false discovery rate calculated with the

Benjamini-Hochberg procedure (as implemented in the R function p.adjust) was used to control

type I error in multiple tests.

Principal component analysis

A principal component analysis (PCA), linear discriminant analysis and kernel density

estimation analysis were performed to reduce the number of features, obtain the sample

distribution along one direction, and visualize the progression of ACLF based on high-

dimension transcriptomics data. The gene expression read count was used to perform the PCA

(R, ‘svd’ function). The directions of the trend lines in the PCA plot were determined by

conducting a linear discriminant analysis (python v3.7, ‘math’ package) based on the top two

principal components that separated the groups of interest. The kernel density estimation

analysis (python v3.7, ‘kdeplot’ function with ‘Gaussian’ kernel) was performed to illustrate

the probability density distribution of the samples in the groups of interest.

Hierarchical clustering of gene expression

An unsupervised hierarchical clustering analysis was performed to estimate the similarity

among different samples based on the significantly differentially expressed genes. Gene

expression values were centred and scaled. The R function ‘pheatmap’ was used to plot the gene

expression heat map and perform hierarchical clustering of DEGs obtained from multigroup

and two-group comparisons. Pearson’s correlation coefficient was used as a distance measure

in clustering. A complete linkage method was used for all the tests.

Functional synergy analysis and sliding window analysis

The functional synergy analysis based on GSLA23 and sliding window analysis using publicly

available gene sets (GO KEGG, Reactome, etc.) were performed to anticipate and illustrate the

alterations in biological processes of DEG collections with different variations in expression.

DEGs between two different disease stages were detected using the methods described above

and sorted according to their adjusted P values for each comparison. A sliding window with a

size of 100 and a step of 50 was used to sample the DEGs to create collections of DEGs with

similar expression variations. The significance criteria used for the GSLA were a density >0.01

and a P value ≤ 1×10-4.

Network analysis of DEG functions

A network analysis of annotated DEG functions was performed to interpret the most prominent

biological processes that were altered during disease progression. Biological processes for each

DEG collection were identified using GSLA, as described above. The relationship between

different biological processes was calculated based on the genes shared by each biological

process. A binary matrix that includes biological processes and their target genes was

established. Based on this matrix, the kappa statistical test was used to calculate the strength of

association between the biological functions. The kappa score threshold was set to 0.3. The size

of each node represents the number of genes associated with each biological process. The

network was visualized with Cytoscape (version 3.7.1).24

Gene expression pathway analysis

A gene expression pathway analysis based on the KEGG pathways was performed using GSEA,

which is based on absolute expression to quantify the degree to which a gene set is

overrepresented in a particular sample, rather than differential expression between two groups,

to further investigate metabolic alterations across disease development stages. The significance

criterion used for the GSEA was a P value <0.05. The NES was calculated by the GSEA to

compare the degree of enrichment across gene sets.

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SUPPLEMENTARY FIGURES AND TABLES

Supplementary Figure 1. Kernel density estimation analysis of the distributions of the ACLF

group, ACHD group and combined LC, CHB and NC groups based on the PCA results.

Supplementary Figure 2. Hierarchal clustering analysis of significant DEGs in the multigroup

comparison among the ACLF, ACHD, LC, CHB and NC groups. The significance was defined

as a ‘q value < 0.05’.

Supplementary Figure 3. The allocation map of seven general biological processes

based on GO terms. The terms are the results of the GSLA of the top 500 DEGs

identified in pairwise comparisons. The seven general biological processes related to

the PBMC response are virus, immune, inflammation, apoptosis, metabolism,

coagulation, and wounding processes. From outside to inside the circos plot, the most

significantly altered GO terms, the adjusted P value of DEGs, log2-fold change of

DEGs, and baseMean of DEG expression are shown. These results were calculated

using DESeq2. (A) The allocation of GO terms in the comparison of the ACLF and NC

groups. (B) The allocation of GO terms in the comparison of the ACHD and NC groups.

allocation of GO terms in the comparison of the CHB and NC groups.

A B ACLF with Coagulation Failure log2FC Complement and coagulation cascades vs. 2 CHB LC ACHD ACLF ACLF without vs. vs. vs. vs. Coagulation NC NC NC NC Failure 1 COMPLEMENT AND COAGULATION CASCADES NES 1.48 1.49 1.47 GLYCOSPHINGOLIPID BIOSYNTHESIS SERPINB2 PLAU F3 VSIG4 C7 THBD C1QB PLAUR C4BPA C1QC CPB2 F11 C5AR1 TFPI CD55 C1QA A2M F8 C1S F12 SERPING1 KNG1 CR2 F2RL2 C8G F2RL3 F2R F7 F2 C8B 1.5 GLYCOSPHINGOLIPID BIOSYNTHESIS 0 1.58 PATHWAY 1 1.51 1.69 HIF−1 SIGNALLING 1.44 1.51 1.55 INSULIN RESISTANCE 0.5 AUTOPHAGY −1 1.43 1.69 0 1.74 FC GAMMA R−MEDIATED PHAGOCYTOSIS GLYCOSAMINOGLYCAN BIOSYNTHESIS 1.61 1.67 −0.5 AMPK SIGNA LING PATHWAY −2 1.55 1.56 L OSTEOCLAST DIFFERENTIATION −1 1.62 1.73 LYSOSOME 1.64 1.73 Glycosphingolipid biosynthesis PARATHYROID HORMONE SYNTHESIS −1.5 1.53 1.59 1.45 1.54 VASOPRESSIN−REGULATED WATER REABSORPTION LEU OCYTE TRANSENDOTHELIAL MIGRATION 1.59 C MTOR SIGNAL ING PATHWAY 1.46 1.46 L 1.71 GLUCAGON SIGNALLING PATHWAY 1.48 FUT3 B3GNT5 B3GALNT1 FUT4 B3GALT2 ST3GAL4 B4GALT1 B4GALT4 A4GALT B3GNT2 FUT7 B3GALT1 ST3GAL6 GCNT2 ST3GAL3 B4GALT3 FUT1 B3GNT4 B4GALT2 FUT2 ST8SIA1 B3GNT3 INSULIN SIGNA LING PATHWAY 1.46 1.48 L 1.57 CHOLESTEROL METABOLISM UBIQUITIN MEDIATED PROTEOLYSIS 1.65 1.61 MINERAL ABSORPTION 1.61 1.40 PPAR SIGNALLING PATHWAY REGULATION OF ACTIN CYTOSKELETON 1.46 ADIPOCYTOKINE SIGNAL ING PATHWAY 1.48 1.48 L CELLULAR SENESCENCE 1.36 1.45 1.55 FERROPTOSIS Glycosphingolipid biosynthesis PHAGOSOME 1.49 1.53 OTHER GLYCAN DEGRADATION 1.58 1.45 SPHINGOLIPID METABOLISM 1.44 RELAXIN SIGNALLING PATHWAY MITOPHAGY 1.50 1.49 1.54 1.52 NOTCH SIGNAL ING PATHWAY A3GALT2 B3GALNT1 HEXB A4GALT GLA HEXA ST3GAL1 NAGA ST3GAL2 GBGT1 FUT1 FUT2 ST8SIA1 1.52 1.56 L THYROID HORMONE SIGNAL ING PATHWAY 1.46 L 1.39 1.52 LONG−TERM DEPRESSION 1.52 C−TYPE LECTIN RECEPTOR SIGNALLING PATHWAY −1.45 −1.56 FANCONI ANEMIA PATHWAY 1.57 1.52 NEUROTROPHIN SIGNALLING PATHWAY −1.68 −1.63 AMINOACYL−TRNA BIOSYNTHESIS 1.47 NEOMYCIN −1.64 SELENOCOMPOUND METABOLISM 1.47 ARACHIDONIC ACID METABOLISM 1.53 PORPHYRIN AND CHLOROPHYLL METABOLISM 1.51 DRUG METABOLISM 1.50 SULFUR RELAY SYSTEM 1.42 SYNAPTIC VESICLE CYCLE 1.50 GLUTATHIONE METABOLISM 1.46 MATURITY ONSET DIABETES OF THE YOUNG −1.86 MISMATCH REPAIR −1.86 VALINE −1.79 NUCLEOTIDE EXCISION REPAIR −1.75 BUTANOATE METABOLISM −1.80 PROPANOATE METABOLISM 1.56 LONGEVITY REGULATING PATHWAY −1.54 SYNTHESIS AND DEGRADATION OF KETONE BODIES 1.56 LONG−TERM POTENTIATION −1.46 PEROXISOME

Supplementary Figure 4. Regulation of metabolism in patients with ACLF and

coagulation failure. (A) Metabolic pathways that were significantly altered in patients

with ACLF and coagulation failure based on enriched KEGG pathways. Pathways in

which gene expression was increased or decreased are shown in red and blue,

respectively. Only pathways with a NOM P value <0.05 are depicted here. The colour

is proportional to the NES calculated by the GSEA. (B) Heatmap of genes from selected

KEGG-derived metabolic pathways. For each pathway, the top 30 DEGs are shown

(adjusted P value <0.05). (All DEGs are shown if <30 genes are detected). Genes with

higher (red) or lower (blue) expression are proportionally displayed. Significantly

differentially expressed genes (|log2-fold change| >1.5) are shown in bold.

A B CHB LC ACHD ACLF ACLF with HE vs. vs. vs. vs. vs. log2FC NC NC NC NC ACLF without HE Parathyroid hormone synthesis, secretion and action Inositol phosphate metabolism NES 2 1.53 1.59 1.39 PARATHYROID HORMONE SYNTHESIS 1.5 1.46 LONGEVITY REGULATING PATHWAY NATURAL KILLER CELL MEDIATED CYTOTOXICITY −1.40 1 1 SELENOCOMPOUND METABOLISM −1.64 −1.42 A3 A2 −1.37 APOPTOSIS AT EGFR SLC34A2 TRPV5 CREB5 CREB3L1 MAFB PLCB4 CDKN1A MMP25 PRKCG PLD1 LRP6 TNFSF11 GNAQ MMP14 MEF2A SP1 MEF2C MMP15 PDE4C JUND ITPR3 LRP5 SLC9A3R1 ADCY1 G BGLAP SLC34A1 CREB3L3

0.5 PLCB4 OCRL PIP5K1B IMP ITPKA PIK3CB MTM1 PTEN IPMK ITPK1 MTMR3 FIG4 PIKFYVE MTMR7 MTMR6 PIP4K2A MINPP1 IPPK PI4K2B PIP4K2C ITPKB INPP5E INPP5K PLCH2 MIOX PLCD1 ISYNA1 PLCG1 INPP5J PIP5KL1 AMINOACYL−TRNA BIOSYNTHESIS −1.68 −1.63 −1.36 0 0 1.44 1.28 RELAXIN SIGNALLING PATHWAY 1.46 INOSITOL PHOSPHATE METABOLISM −0.5 1.27 OXYTOCIN SIGNALLING PATHWAY −1.50 TYPE I DIABETES MELLITUS −1 −1 −1.24 ADRENERGIC SIGNALLING IN CARDIOMYOCYTES 1.50 −1.45 SULFUR RELAY SYSTEM −1.5 1.46 STARCH AND SUCROSE METABOLISM −2 −1.68 TH1 AND TH2 CELL DIFFERENTIATION −1.58 TH17 CELL DIFFERENTIATION −1.22 RAS SIGNALLING PATHWAY −1.39 PROXIMAL TUBULE BICARBONATE RECLAMATION Longevity regulating pathway Oxytocin signalling pathway −1.24 CELL ADHESION MOLECULES (CAMS) 1.51 1.69 HIF−1 SIGNALLING PATHWAY 1.44 1.51 1.55 INSULIN RESISTANCE AUTOPHAGY

1.43 1.69 G3 G3 C1 A1B A2 T1

ATED PHAGOCYTOSIS O1 XO3 1.74 FC GAMMA R−MEDI TC4 GLYCOSAMINOGLYCAN BIOSYNTHESIS CNB4 CNA1D CNA2D3 CNA1C CNG4 CNA2D2 YR2 1.61 1.67 CRYAB IGF1 FO INSR CLPB IRS2 IGF1R CAT PIK3CB PRKAB2 PRKACA SOD2 SIR NRAS KRAS HDA RPS6KB2 AKT2 IRS1 SOD1 HSP PRKACB ADCY5 RPTOR HRAS HSP ADCY1 PIK3R3 PRKA PIK3R2 PLA2G4B 1.55 1.56 AMPK SIGNALLING PATHWAY EGFR CAMK1G NFA MYLK3 PLA2G4A KCNJ5 PLCB4 CDKN1A CA CA KCNJ2 CA KCNJ9 PRKCG GNAQ HRAS ADCY1 GUCY1B1 CALML6 NPR2 CA CA JUN PRKA CAMK2B GNA PLA2G4C R CA 1.62 1.73 OSTEOCLAST DIFFERENTIATION 1.64 1.73 LYSOSOME 1.45 1.54 VASOPRESSIN−REGULATED WATER REABSORPTION 1.59 LEUCOCYTE TRANSENDOTHELIAL MIGRATION 1.46 1.46 MTOR SIGNALLING PATHWAY 1.71 1.48 GLUCAGON SIGNALLING PATHWAY 1.46 1.48 INSULIN SIGNALLING PATHWAY 1.57 CHOLESTEROL METABOLISM 1.65 1.61 UBIQUITIN MEDIATED PROTEOLYSIS 1.61 MINERAL ABSORPTION 1.48 COMPLEMENT AND COAGULATION CASCADES Relaxin signalling pathway Starch and sucrose metabolism 1.40 PPAR SIGNALLING PATHWAY 1.46 REGULATION OF ACTIN CYTOSKELETON 1.48 1.48 ADIPOCYTOKINE SIGNALLING PATHWAY 1.36 1.45 CELLULAR SENESCENCE O1 1.55 FERROPTOSIS AMY1A MGAM2 MGAM GYS2 GBE1 GAA GANC PGM2 HK1 G6PC3 PYGL GYG1 HK2 AMY1B PGM1 GCK PGM2L1 GYS1 GPI AMY2B UGP2 HK3 PYGB PYGM AGL HKDC1 ENPP3 ENPP1 AMY1C 1.49 1.53 PHAGOSOME EGFR COL3A1 COL1A2 COL4A5 RXFP2 GNG12 MMP9 MMP2 GNG10 CREB5 CREB3L1 PLCB4 GNG3 EDNRB NOS2 ADCY1 PIK3R3 RXFP4 VEGFC INSL3 COL1A1 GNB3 MAPK10 JUN GNA MAPK11 SHC3 PIK3R2 GNG4 CREB3L3 1.58 OTHER GLYCAN DEGRADATION 1.45 SPHINGOLIPID METABOLISM 1.50 1.49 1.54 1.52 MITOPHAGY 1.52 1.56 NOTCH SIGNALLING PATHWAY 1.46 THYROID HORMONE SIGNALLING PATHWAY 1.39 1.52 LONG−TERM DEPRESSION 1.52 C−TYPE LECTIN RECEPTOR SIGNALLING PATHWAY −1.45 −1.56 FANCONI ANEMIA PATHWAY 1.57 1.52 NEUROTROPHIN SIGNALLING PATHWAY 1.47 NEOMYCIN 1.47 ARACHIDONIC ACID METABOLISM 1.53 PORPHYRIN AND CHLOROPHYLL METABOLISM 1.51 DRUG METABOLISM 1.42 SYNAPTIC VESICLE CYCLE 1.50 GLUTATHIONE METABOLISM 1.46 MATURITY ONSET DIABETES OF THE YOUNG −1.86 MISMATCH REPAIR VALINE −1.86 −1.79 NUCLEOTIDE EXCISION REPAIR −1.75 BUTANOATE METABOLISM −1.80 PROPANOATE METABOLISM 1.56 LONGEVITY REGULATING PATHWAY −1.54 SYNTHESIS AND DEGRADATION OF KETONE BODIES 1.56 LONG−TERM POTENTIATION −1.46 PEROXISOME

Supplementary Figure 5. Regulation of metabolism in patients with ACLF and

cerebral dysfunction. (A) Metabolic pathways that were significantly altered in patients

with ACLF and cerebral dysfunction based on KEGG pathways. Pathways in which

gene expression was increased or decreased are shown in red and blue, respectively.

Only pathways with a NOM P value <0.05 depicted here. The colour is proportional to

the NES calculated by the GSEA. (B) Heatmap of genes from selected KEGG-derived

metabolic pathways. For each pathway, the top 30 DEGs are shown (adjusted P value

<0.05). (All DEGs are shown if <30 were detected). Genes expressed at higher (red) or

lower (blue) levels are proportionally displayed. Significantly differentially expressed

genes (|log2-fold change| >1.5) are shown in bold.

Supplementary Table 1. qPCR primers used in the study Name Sequence Gene ID F CTCTCTGCTCCTCCTGTTCG hGAPDH 2597 R ACGACCAAATCCGTTGACTC F AGGCATGTTCCAGTTTCACC hTHBS 7057 R GCTGGCACCACCTTTATTGT F GACCACTCCCACTCCTTTGA hPPARG 5468 R GATGCAGGCTCCACTTTGAT F ACTTCAGCCACCCAAATGTC hMERTK 10461 R GGGCAATATCCACCATGAAC F CAGAATCCCTGAGCCAGAAG hSEMA6B 10501 R CCAGAAAGGGGTACAGTCCA F ATGGAGAAGGCTGGGGCTCACCT rGAPDH 24382 R AGCCCTTCCACGATGCCAAAGTTGT F TAGCTGGAAATGTGGTGCGT rTHBS1 445442 R AGTCTTCCTGCCCCGAATTG F TCCCGTTCACAAGAGCTGAC rPPARG 25664 R TGGCACCCTTGAAAAATGCG F CGTGGTGGAAAGATGGAAAGG rMERTK 65037 R ACCCCTTCCTCATCAGGATAAA F ACAAAGTCAGGGGATGGCTG rSEMA6B 84609 R ATTCTTGCATACACGGGCCA

Supplementary Table 2. Antibodies used for IHC and haematoxylin-eosin staining Antibodies Source Cat. No. Species Anti-human SEMA6B antibody Abcam, Cambridge, UK ab180215 Rabbit Anti-human PPAR gamma antibody Abcam, Cambridge, UK ab209350 Rabbit Anti-human thrombospondin antibody Abcam, Cambridge, UK ab1823 Mouse Anti-human MERTK antibody Abcam, Cambridge, UK ab52968 Rabbit Anti-rat SEMA6B antibody Santa Cruz Biotechnology, CA, USA sc-390928 Mouse Anti-rat PPAR gamma antibody Abcam, Cambridge, UK ab209350 Rabbit Anti-rat thrombospondin antibody Abcam, Cambridge, UK ab1823 Mouse Anti-rat MERTK antibody Bioss, Atlanta, GA, USA bs-0548R Rabbit Anti-beta actin antibody Abcam, Cambridge, UK ab8226 Mouse

Supplementary Table 3. Clinical characteristics of patients in the mRNA sequencing group

ACLF ACHD LC CHB NC Characteristics (n=20) (n=10) (n=10) (n=10) (n=15) Age (years.) 47.5 [43.0, 54.0] 41.0 [35.5, 45.5] 47.5 [43.0, 52.0] 42.0 [37.2, 51.0] 47.0 [37.0, 50.0] Male (No.) 85.0% (17) 90.0% (9) 90.0% (9) 70.0% (7) 80.0% (12) HBV DNA level (IU/mL) significancea significancea significancea ≤ 2×102 10.0% (2) 40.0% (4) 90.0% (9) 90.0% (9) NA 2×102 - 2×106 80.0% (16) 60.0% (6) 10.0% (1) 10.0% (1) NA > 2×106 10.0% (2) 0 0 0 NA Laboratory data Alanine aminotransferase (U/L) 242.0 [100.0, 548.0] 41.9 [29.7, 134.5] ** 23.5 [20.5, 26.0] *** 24.5 [21.2, 41.0] *** 20.0 [13.0, 28.5] *** Aspartate aminotransferase (U/L) 127.5 [77.7, 164.2] 48.0 [33.2, 106.2] ** 22.5 [21.2, 24.7] *** 24.0 [21.3, 24.7] *** 20.0 [18.0, 26.5] *** Albumin (g/L) 32.2 ± 3.7 32.5 ± 5.7 46.1 ± 2.9 *** 49.4 ± 2.5 *** 47.9 ± 3.1 *** Total bilirubin (µmol/L) 376.5 [277.5, 460.7] 73.0 [26.0, 165.7] *** 13.5 [12.2, 18.2] *** 14.0 [10.0, 17.5] *** 10.0 [9.0, 12.5] *** Alkaline phosphatase (U/L) 139.5 [121.7, 177.5] 100.0 [87.0, 118.0] * 82.0 [69.5, 103.7] ** 72.0 [65.0, 86.0] ** 68.0 [55.5, 78.5] *** γ-glutamyl transpeptidase (U/L) 78.0 [59.7, 122.2] 46.0 [24.5, 91.0] 26.5 [17.7, 41.2] *** 22.5 [13.0, 26.7] *** 21.0 [14.0, 32.0] *** Creatinine (μmol/L) 64.0 [51.7, 72.0] 64.4 [58.2, 71.2] 72.0 [65.0, 85.0] 73.5 [53.5, 84.5] 84.0 [77.0, 87.0] * Sodium (mmol/L) 137.1 ± 3.5 139.4 ± 3.7 141.3 ± 2.5 ** 141.8 ± 2.6 ** 142.2 ± 2.6 *** White blood cell count (109/L) 7.4 [6.0, 9.3] 5.1 [4.3, 6.6] 4.5 [4.0, 6.1] * 5.8 [5.1, 6.2] * 6.1 [5.5, 6.9] Hemoglobin (g/L) 129.0 [121.2, 136.7] 129.5 [101.5, 135.5] 155.0 [149.0, 161.2] ** 155.5 [143.0, 167.5] ** 149.5 [143.7, 154.5] * Hematocrit (%) 36.2 [33.7, 39.7] 37.3 [30.3, 40.2] 46.1 [44.6, 47.8] *** 45.7 [41.5, 47.9] *** 44.5 [43.0, 46.5] ** Platelet count (109/L) 113.5 [75.5, 152.5] 117.0 [42.0, 176.5] 124.0 [96.5, 151.0] 172.5 [142.5, 192.0] * 223.5 [195.0, 261.2] *** INR 2.3 ± 0.6 1.4 ± 0.4 *** 1.0 ± 0.0** 1.0 ± 0.1*** NA Alpha fetoprotein (μg/L) 138.7 [58.0, 222.7] 4.5 [2.5, 278.3] * 2.2 [1.7, 2.9] *** 1.0 [1.0, 1.0] *** 2.90 [1.80, 4.10] ** Organ failure (No.) Liver 10.0% (20) 20.0% (2) *** 0 *** 0 *** 0 ***

Coagulation 40.0% (8) 0 * 0 * 0 * 0 * Kidney 0 0 0 0 0 Cerebral 5.0% (1) 0 0 0 0 Lung 0 0 0 0 0 Circulation 0 0 0 0 0 Severity score COSSH-ACLFs 6.5 ± 1.0 NA NA NA NA CLIF-C ACLFs 43.3 ± 5.7 NA NA NA NA MELD 23.92 ± 4.82 NA NA NA NA Short-term mortality (Number of deceased) 28-day 40.0% (8) 10.0% (1) * 0* 0* NA 90-day 45.0% (9) 10.0% (1) * 0* 0* NA

NOTES. Data are presented as the means ± SD, medians with [p25, p75], or percentages (numbers of patients). ACLF, acute-on-chronic liver failure; ACHD, acute-on-chronic hepatic dysfunction; LC, liver cirrhosis; CHB, chronic hepatitis B; NC, normal control. COSSH-ACLFs, COSSH-ACLF score; CLIF-C ACLFs, CLIF Consortium ACLF score; and MELD, Model for End-Stage Liver Disease. a P value (<0.001) for comparisons of the HBV DNA distribution between the ACHD/LC/CHB/NC and ACLF groups. * P<0.05, ** P<0.01 and *** P<0.001 for comparisons between the ACHD/LC/CHB/NC and ACLF groups.

Supplementary Table 4. Qualitative analysis of transcriptomes in the sequencing group

Trimmomatic HISAT2

ID Forward Reverse aligned Gene number Input Read Both Aligned Aligned Alignment Only Only Dropped: Paired exactly 1 Pairs: Surviving: 0 times >1 times rate Surviving: Surviving: time 33338803 5471221 78638 81292 33338803 1896882 24671862 6770059 ACLF_S1 38969954 97.54% 26415 (85.55%) (14.04%) (0.20%) (0.21%) (100.00%) (5.69%) (74.00%) (20.31%) 40061007 6831859 90635 99431 40061007 2327173 28732267 9001567 ACLF_S2 47082932 97.44% 27779 (85.09%) (14.51%) (0.19%) (0.21%) (100.00%) (5.81%) (71.72%) (22.47%) 38436672 5451777 84697 76753 38436672 2208028 29027051 7201593 ACLF_S3 44049899 97.44% 27612 (87.26%) (12.38%) (0.19%) (0.17%) (100.00%) (5.74%) (75.52%) (18.74%) 29884910 4450242 71743 70608 29884910 1620732 22707829 5556349 ACLF_S4 34477503 97.66% 26385 (86.68%) (12.91%) (0.21%) (0.20%) (100.00%) (5.42%) (75.98%) (18.59%) 29797131 4850068 66682 75033 29797131 1804970 22386006 5606155 ACLF_S5 34788914 97.36% 26382 (85.65%) (13.94%) (0.19%) (0.22%) (100.00%) (6.06%) (75.13%) (18.81%) 33212441 5324831 75967 73322 33212441 2002889 24868874 6340678 ACLF_S6 38686561 97.32% 26625 (85.85%) (13.76%) (0.20%) (0.19%) (100.00%) (6.03%) (74.88%) (19.09%) 28441000 4685440 36276 35769 28441000 2001152 21646605 4793243 ACLF_S7 33198485 96.59% 24164 (85.67%) (14.11%) (0.11%) (0.11%) (100.00%) (7.04%) (76.11%) (16.85%) 29337090 4996030 40699 35688 29337090 2119111 22547899 4670080 ACLF_S8 34409507 96.41% 24787 (85.26%) (14.52%) (0.12%) (0.10%) (100.00%) (7.22%) (76.86%) (15.92%) 24613820 4086986 31633 33322 24613820 2966781 17980139 3666900 ACLF_S9 28765761 91.29% 20241 (85.57%) (14.21%) (0.11%) (0.12%) (100.00%) (12.05%) (73.05%) (14.90%) 31996550 4360814 41021 38187 31996550 2101456 24530390 5364704 ACLF_S10 36436572 96.75% 26444 (87.81%) (11.97%) (0.11%) (0.10%) (100.00%) (6.57%) (76.67%) (16.77%) 29816127 3904847 38032 32856 29816127 2029126 22687835 5099166 ACLF_S11 33791862 96.30% 25981 (88.23%) (11.56%) (0.11%) (0.10%) (100.00%) (6.81%) (76.09%) (17.10%) 27757677 4418937 36692 33085 27757677 2138161 21132661 4486855 ACLF_S12 32246391 95.72% 23119 (86.08%) (13.70%) (0.11%) (0.10%) (100.00%) (7.70%) (76.13%) (16.16%) 29128222 4433265 69731 68292 29128222(1 1704023 21903722 5520477 ACLF_S13 33699510 97.45% 26679 (86.44%) (13.16%) (0.21%) (0.20%) 00.00%) (5.85%) (75.20%) (18.95%) 25063517 3984771 53513 65335 25063517 2258141 17714787 5090589 ACLF_S14 29167136 94.96% 27569 (85.93%) (13.66%) (0.18%) (0.22%) (100.00%) (9.01%) (70.68%) (20.31%) 31275455 4874031 73599 70941 31275455 1844667 23510464 5920324 ACLF_S15 36294026 97.55% 26598 (86.17%) (13.43%) (0.20%) (0.20%) (100.00%) (5.90%) (75.17%) (18.93%) 32423759 4059680 87955 81407 32423759 1743005 24488696 6192058 ACLF_S16 36652801 97.49% 25145 (88.46%) (11.08%) (0.24%) (0.22%) (100.00%) (5.38%) (75.53%) (19.10%) 18941291 2793653 50438 46755 18941291 1125823 14270327 3545141 ACLF_S17 21832137 97.31% 27303 (86.76%) (12.80%) (0.23%) (0.21%) (100.00%) (5.94%) (75.34%) (18.72%) 24010868 4012591 61104 71179 24010868 1381352 14761707 7867809 ACLF_S18 28155742 97.18% 27067 (85.28%) (14.25%) (0.22%) (0.25%) (100.00%) (5.75%) (61.48%) (32.77%) 29057206 3984361 79173 78416 29057206 1990026 21287967 5779213 ACLF_S19 33199156 96.08% 24859 (87.52%) (12.00%) (0.24%) (0.24%) (100.00%) (6.85%) (73.26%) (19.89%) 30317217 4487503 78815 86855 30317217 1665952 22649940 6001325 ACLF_S20 34970390 97.48% 25695 (86.69%) (12.83%) (0.23%) (0.25%) (100.00%) (5.50%) (74.71%) (19.80%) 62396904 18223887 135187 214330 62396904 3906828 46735613 11754463 ACHD_S1 80970308 97.77% 28886 (77.06%) (22.51%) (0.17%) (0.26%) (100.00%) (6.26%) (74.90%) (18.84%) 33556409 10813869 70133 190936 33556409 1788564 17717201 14050644 ACHD_S2 44631347 97.90% 25768 (75.19%) (24.23%) (0.16%) (0.43%) (100.00%) (5.33%) (52.80%) (41.87%) 58776905 19161810 120850 341093 58776905 4229204 42325055 12222646 ACHD_S3 78400658 97.14% 28689 (74.97%) (24.44%) (0.15%) (0.44%) (100.00%) (7.20%) (72.01%) (20.79%) 37096566 11358796 80791 162536 37096566 2362388 27867072 6867106 ACHD_S4 48698689 97.45% 28087 (76.18%) (23.32%) (0.17%) (0.33%) (100.00%) (6.37%) (75.12%) (18.51%) 26761467 4231056 34798 28018 26761467 1470111 21063819 4227537 ACHD_S5 31055339 97.85% 26494 (86.17%) (13.62%) (0.11%) (0.09%) (100.00%) (5.49%) (78.71%) (15.80%) 44762170 8905304 59179 57801 44762170 2762982 34378541 7620647 ACHD_S6 53784454 97.57% 25258 (83.23%) (16.56%) (0.11%) (0.11%) (100.00%) (6.17%) (76.80%) (17.02%) 34827160 5749270 46681 32679 34827160 1975634 27256949 5594577 ACHD_S7 40655790 97.82% 26713 (85.66%) (14.14%) (0.11%) (0.08%) (100.00%) (5.67%) (78.26%) (16.06%) ACHD_S8 38332471 30818123 7320622 44625 149101 30818123 3003965 22223843 5590315 94.64% 27176

(80.40%) (19.10%) (0.12%) (0.39%) (100.00%) (9.75%) (72.11%) (18.14%) 29410180 6156186 39419 94902 29410180 2509201 21827400 5073579 ACHD_S9 35700687 95.62% 25153 (82.38%) (17.24%) (0.11%) (0.27%) (100.00%) (8.53%) (74.22%) (17.25%) 31693798 7680194 42126 101681 31693798 3315090 22856411 5522297 ACHD_S10 39517799 93.91% 23557 (80.20%) (19.43%) (0.11%) (0.26%) (100.00%) (10.46%) (72.12%) (17.42%) 29407666 5317850 102447 98530 29407666 1680357 21843715 5883594 LC_S1 34059685 97.43% 25936 (86.34%) (12.45%) (0.24%) (0.23%) (100.00%) (5.71%) (74.28%) (20.01%) 37185647 4244248 79777 71748 37185647 2057552 27919642 7208453 LC_S2 42704474 97.50% 27104 (87.08%) (12.15%) (0.23%) (0.21%) (100.00%) (5.53%) (75.08%) (19.39%) 28280071 5900547 59401 89395 28280071 1949990 20452671 5877410 LC_S4 34607261 96.95% 27169 (81.72%) (15.54%) (0.16%) (0.24%) (100.00%) (6.90%) (72.32%) (20.78%) 31910127 7615231 65487 94491 31910127 2045916 23530883 6333328 LC_S5 37959470 97.17% 27943 (84.06%) (17.24%) (0.15%) (0.21%) (100.00%) (6.41%) (73.74%) (19.85%) 36385774 5524104 56133 69014 36385774 2639971 26511757 7234046 LC_S6 44160983 96.78% 28989 (82.39%) (15.27%) (0.16%) (0.19%) (100.00%) (7.26%) (72.86%) (19.88%) 30521604 6018217 61923 83251 30521604 2071733 22721547 5728324 LC_S7 36170855 96.92% 27631 (84.38%) (14.99%) (0.15%) (0.21%) (100.00%) (6.79%) (74.44%) (18.77%) 33994968 5316926 72774 89687 33994968 2308756 24979729 6706483 LC_S8 40158359 96.79% 28576 (84.65%) (14.97%) (0.20%) (0.25%) (100.00%) (6.79%) (73.48%) (19.73%) 30037449 3139972 63583 53463 30037449 2027896 21884269 6125284 LC_S9 35516836 96.70% 26181 (84.57%) (11.57%) (0.23%) (0.20%) (100.00%) (6.75%) (72.86%) (20.39%) 37522212 9063435 57145 126624 37522212 3679013 27392228 6450971 LC_S10 46869568 94.72% 27159 (80.06%) (17.81%) (0.11%) (0.25%) (100.00%) (9.80%) (73.00%) (17.19%) 30141256 4215674 85305 72457 30141256 1679142 22690833 5771281 CHB_S1 34514692 97.53% 26659 (87.33%) (12.21%) (0.25%) (0.21%) (100.00%) (5.57%) (75.28%) (19.15%) 30610648 4829959 87361 78405 30610648 1783293 22709457 6117898 CHB_S2 35606373 97.45% 26250 (85.97%) (13.56%) (0.25%) (0.22%) (100.00%) (5.83%) (74.19%) (19.99%) 30449573 6975634 87145 103670 30449573 2558108 21883873 6007592 CHB_S3 38623454 96.38% 27411 (78.84%) (20.28%) (0.25%) (0.30%) (100.00%) (8.40%) (71.87%) (19.73%) 27238337 5968075 87819 112401 27238337 2018132 19487311 5732894 CHB_S4 34404786 96.90% 26053 (79.17%) (18.86%) (0.28%) (0.36%) (100.00%) (7.41%) (71.54%) (21.05%) 25472287 4940580 72272 105565 25472287 1791131 18452447 5228709 CHB_S5 31640582 97.08% 26349 (80.51%) (17.78%) (0.26%) (0.38%) (100.00%) (7.03%) (72.44%) (20.53%) 22675079 5565489 82472 118978 22675079 1574462 16449935 4650682 CHB_S6 27793496 96.71% 26866 (81.58%) (18.31%) (0.27%) (0.39%) (100.00%) (6.94%) (72.55%) (20.51%) 24635033 4287086 71440 91325 24635033 1718270 17823633 5093130 CHB_S7 30401972 96.79% 26035 (81.03%) (16.89%) (0.28%) (0.36%) (100.00%) (6.97%) (72.35%) (20.67%) 20932325 9176624 51173 119559 20932325 1405362 15206228 4320735 CHB_S8 25382176 96.91% 26476 (82.47%) (19.58%) (0.11%) (0.26%) (100.00%) (6.71%) (72.64%) (20.64%) 24940779 5770708 86240 113045 24940779 1785828 17928419 5226532 CHB_S9 30910772 96.76% 26765 (80.69%) (18.67%) (0.28%) (0.37%) (100.00%) (7.16%) (71.88%) (20.96%) 27233502 7002139 91679 124770 27233502 1969409 19436562 5827531 CHB_S10 34452090 96.94% 26691 (79.05%) (20.32%) (0.27%) (0.36%) (100.00%) (7.23%) (71.37%) (21.40%) 26108817 4546868 66781 82443 26108817 1741620 18945843 5421354 NC_S1 31697487 96.87% 26994 (82.37%) (17.36%) (0.25%) (0.31%) (100.00%) (6.67%) (72.56%) (20.76%) 21499996 4459119 69265 94399 21499996 1397349 15564660 4537987 NC_S2 26196088 97.05% 26158 (82.07%) (17.41%) (0.27%) (0.37%) (100.00%) (6.50%) (72.39%) (21.11%) 20993055 4457358 92934 80029 20993055 1433017 15177119 4382919 NC_S3 25615838 96.76% 26740 (81.95%) (11.28%) (0.24%) (0.20%) (100.00%) (6.83%) (72.30%) (20.88%) 34896733 3808603 71599 62182 34896733 1901118 25813288 7182327 NC_S4 39527054 97.50% 27414 (88.29%) (11.37%) (0.21%) (0.19%) (100.00%) (5.45%) (73.97%) (20.58%) 29542778 3673521 68197 70480 29542778 1664039 21937994 5940745 NC_S5 33485162 97.35% 27787 (88.23%) (11.61%) (0.22%) (0.22%) (100.00%) (5.63%) (74.26%) (20.11%) 27820049 3975471 79519 66673 27820049 1500665 20771599 5547785 NC_S6 31632247 97.47% 26510 (87.95%) (11.70%) (0.23%) (0.20%) (100.00%) (5.39%) (74.66%) (19.94%) 29849164 4150612 81135 75847 29849164 1655846 22298703 5894615 NC_S7 33970827 97.51% 26432 (87.87%) (11.35%) (0.22%) (0.21%) (100.00%) (5.55%) (74.70%) (19.75%) 32263900 4606540 66600 79192 32263900 1682254 23688950 6892696 NC_S8 36571494 97.63% 26808 (88.22%) (13.88%) (0.20%) (0.24%) (100.00%) (5.21%) (73.42%) (21.36%) 23876562 4164057 83017 70103 23876562 1366323 17759828 4750411 NC_S10 27133580 97.38% 24731 (88.00%) (11.49%) (0.23%) (0.19%) (100.00%) (5.72%) (74.38%) (19.90%) NC_S11 36229628 31912451 3153821 70621 55537 31912451 1738206 24126949 6047296 97.54% 28207

(88.08%) (10.48%) (0.23%) (0.18%) (100.00%) (5.45%) (75.60%) (18.95%) 26822496 4442965 77725 71316 26822496 1411012 20223586 5187898 NC_S12 30102475 97.59% 26577 (89.10%) (12.66%) (0.22%) (0.20%) (100.00%) (5.26%) (75.40%) (19.34%) 30489125 4550931 75221 68381 30489125 1742525 22523413 6223187 NC_S13 35081131 97.38% 26487 (86.91%) (13.19%) (0.22%) (0.20%) (100.00%) (5.72%) (73.87%) (20.41%) 46345983 6063661 38786 40529 46345983 2409883 36261451 7674649 NC_S14 53956156 98.17% 28560 (85.90%) (14.58%) (0.09%) (0.10%) (100.00%) (5.20%) (78.24%) (16.56%) 35454270 5389894 85973 112803 35454270 1981641 27612339 5860290 NC_S15 41597246 97.89% 26988 (85.23%) (17.00%) (0.27%) (0.36%) (100.00%) (5.59%) (77.88%) (16.53%) ACLF, acute-on-chronic liver failure; ACHD, acute-on-chronic hepatic dysfunction; LC, liver cirrhosis; CHB, chronic hepatitis B; NC, normal control.

Supplementary Table 5. Significantly differential expressed genes in the comparison of ACLF with ACHD

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (ACLF/ACHD) adjustedb

OLIG1 ENSG00000184221 477.2433355 -1.369314487 1.21E-06 0.00066085 APOBR ENSG00000184730 11775.56071 -0.867568046 8.47E-06 0.003204693 IL10 ENSG00000136634 348.3640968 1.529752728 9.23E-06 0.003454464 VSIG4 ENSG00000155659 3937.53917 1.57798054 9.93E-06 0.003680984 OSBP2 ENSG00000184792 443.4067923 -1.485123437 1.32E-05 0.004706728 SMIM1 ENSG00000235169 35.91947046 -1.434602537 1.63E-05 0.00555475 THBS1 ENSG00000137801 69764.74262 1.526306722 1.62E-05 0.00555475 CDKN1C ENSG00000129757 528.4282203 -1.140277105 2.20E-05 0.006960775 GATA1 ENSG00000102145 299.5711897 -1.508498463 2.36E-05 0.007288661 NOTCH3 ENSG00000074181 200.5341848 1.227076826 2.82E-05 0.00821762 MERTK ENSG00000153208 3058.730209 0.953007021 3.06E-05 0.008731161 PTGER2 ENSG00000125384 11070.18165 0.706836324 3.43E-05 0.009635897 NAMPTP1 ENSG00000229644 5739.016792 1.354497517 3.58E-05 0.009878963 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 6. Significantly differential expressed genes in the comparison of ACLF with LC

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (ACLF/LC) adjustedb

TIGD5 ENSG00000179886 467.0217807 -1.395057614 1.73E-18 2.13E-14 COPS2 ENSG00000166200 6441.720767 0.937911322 1.10E-16 6.81E-13 CPTP ENSG00000224051 998.8183437 -1.184293799 1.87E-16 7.98E-13 ZNF786 ENSG00000197362 628.2173942 -0.975398116 1.94E-16 7.98E-13 CDIP1 ENSG00000089486 2047.046496 -1.130769852 3.80E-16 1.04E-12 DDX21 ENSG00000165732 16092.76036 1.070885088 3.42E-16 1.04E-12 TRPV4 ENSG00000111199 338.3178242 1.988890512 2.14E-15 4.41E-12 TCN2 ENSG00000185339 3508.914348 2.194461987 2.00E-15 4.41E-12 THEM6 ENSG00000130193 643.986818 -1.472023446 9.16E-15 1.41E-11 PPARG ENSG00000132170 262.4247487 2.244573375 1.05E-14 1.53E-11 MAR3‘ ENSG00000139266 2188.34346 -1.165488763 1.23E-14 1.69E-11 RIPK2 ENSG00000104312 4128.476543 1.167088095 2.34E-14 2.99E-11 AGTPBP1 ENSG00000135049 17727.14932 0.988322721 3.86E-14 4.54E-11 UBIAD1 ENSG00000120942 1661.044178 -0.808029123 4.52E-14 5.08E-11 GPCPD1 ENSG00000125772 29033.57299 1.150373635 6.98E-14 7.24E-11 CTU1 ENSG00000142544 225.4381888 -1.628511159 7.03E-14 7.24E-11 TKTL2 ENSG00000151005 75.80790865 2.522392351 9.40E-14 9.27E-11 TWF1 ENSG00000151239 5230.295194 0.80280549 9.75E-14 9.27E-11 SEMA6B ENSG00000167680 8167.903746 3.441224204 1.58E-13 1.45E-10 MLXIPL ENSG00000009950 41.00380179 3.071061907 2.26E-13 1.99E-10 MERTK ENSG00000153208 2929.634488 1.822502124 3.62E-13 3.08E-10 TESK1 ENSG00000107140 2787.878496 -0.764709035 4.54E-13 3.73E-10 YOD1 ENSG00000180667 5779.474059 1.345957123 4.83E-13 3.85E-10 TMEM120B ENSG00000188735 2253.089842 -1.189360291 5.17E-13 3.99E-10 RAB20 ENSG00000139832 2839.891029 1.672854887 6.39E-13 4.78E-10 C11orf68 ENSG00000175573 1620.92073 -1.04934631 9.58E-13 6.39E-10 SOCS6 ENSG00000170677 899.6707217 1.214284608 1.13E-12 7.37E-10 NR4A3 ENSG00000119508 384.8822279 2.648503166 2.25E-12 1.39E-09 IMP3 ENSG00000177971 1989.992691 -1.042925112 2.83E-12 1.63E-09 UBE2D3 ENSG00000109332 31713.80437 0.540142974 3.29E-12 1.81E-09 RHOB ENSG00000143878 7016.056783 -1.435791352 6.72E-12 3.26E-09 TMEM223 ENSG00000168569 552.0429689 -0.786459703 7.44E-12 3.47E-09 THBS1 ENSG00000137801 70483.28328 3.084922853 7.41E-12 3.47E-09 DCTN4 ENSG00000132912 6654.669806 1.1983976 7.98E-12 3.58E-09 SDHAF1 ENSG00000205138 629.0021833 -0.923205157 8.54E-12 3.77E-09 RGS14 ENSG00000169220 7213.007788 -0.931839587 9.84E-12 4.13E-09 SYTL1 ENSG00000142765 8147.284335 -1.046724252 9.87E-12 4.13E-09 VPS54 ENSG00000143952 4646.490703 0.815123146 1.04E-11 4.28E-09 INPP5E ENSG00000148384 2289.388203 -0.842775661 1.30E-11 5.19E-09 TBC1D10C ENSG00000175463 15387.38935 -1.075182007 1.37E-11 5.37E-09 UPP1 ENSG00000183696 16483.61445 1.334187503 1.48E-11 5.48E-09 ADM ENSG00000148926 3387.280392 2.113490997 1.49E-11 5.48E-09

TXNL1 ENSG00000091164 5484.027189 0.524949281 1.60E-11 5.77E-09 SLC30A1 ENSG00000170385 4978.519544 1.178490254 1.84E-11 6.24E-09 DBP ENSG00000105516 910.1815399 -1.161271831 1.83E-11 6.24E-09 SDE2 ENSG00000143751 3692.846646 0.978625036 1.97E-11 6.56E-09 RIOK3 ENSG00000101782 8378.480916 1.117766418 2.36E-11 7.73E-09 CREG1 ENSG00000143162 13691.22664 1.306056789 2.38E-11 7.73E-09 MPP1 ENSG00000130830 7123.525969 1.087924886 2.61E-11 8.16E-09 ZEB2 ENSG00000169554 32738.4317 1.145687232 3.59E-11 1.11E-08 NOCT ENSG00000151014 886.4613074 2.035492114 3.65E-11 1.11E-08 ZNF74 ENSG00000185252 537.2521187 -1.448237347 3.80E-11 1.12E-08 ZMYND10 ENSG00000004838 275.7971362 -1.530244105 4.47E-11 1.25E-08 PXMP4 ENSG00000101417 577.8530567 -0.92455804 4.40E-11 1.25E-08 FAM43A ENSG00000185112 361.9819507 -1.586020496 4.77E-11 1.32E-08 LLGL1 ENSG00000131899 2119.471931 -0.754174596 5.11E-11 1.38E-08 AGAP2 ENSG00000135439 3962.398665 -0.894761403 5.13E-11 1.38E-08 DSC2 ENSG00000134755 2201.245692 1.627023183 5.31E-11 1.41E-08 ARHGAP29 ENSG00000137962 433.6978233 2.261583763 5.58E-11 1.47E-08 MAPRE1 ENSG00000101367 14330.26044 0.614607518 5.79E-11 1.50E-08 MAFB ENSG00000204103 19439.5276 1.843098177 6.16E-11 1.59E-08 F5 ENSG00000198734 7971.628618 1.505028418 6.28E-11 1.60E-08 SLC25A22 ENSG00000177542 1551.46024 -0.897741461 7.03E-11 1.77E-08 BORCS6 ENSG00000196544 1119.553906 -1.167286293 7.10E-11 1.77E-08 PPP1R10 ENSG00000204569 2805.128663 -0.780336706 8.66E-11 2.12E-08 CD36 ENSG00000135218 28190.61821 1.641960148 9.71E-11 2.35E-08 PLEKHG3 ENSG00000126822 6024.603533 -1.126560644 9.86E-11 2.36E-08 IRF2BP1 ENSG00000170604 1355.204957 -1.178227429 1.03E-10 2.44E-08 PEX11A ENSG00000166821 121.7498001 -1.258593902 1.26E-10 2.90E-08 ST8SIA4 ENSG00000113532 7778.542656 0.980476466 1.25E-10 2.90E-08 PLBD1 ENSG00000121316 41779.92686 1.553433991 1.37E-10 3.14E-08 ABCA1 ENSG00000165029 4286.177536 1.981467016 1.42E-10 3.21E-08 TMEM167A ENSG00000174695 12978.79189 0.945814841 1.48E-10 3.30E-08 MVK ENSG00000110921 580.3027933 -0.972253112 1.83E-10 4.01E-08 SERTAD2 ENSG00000179833 9126.295225 1.180600519 1.87E-10 4.04E-08 C19orf60 ENSG00000006015 2299.544462 -0.966340604 2.04E-10 4.38E-08 CEP89 ENSG00000121289 967.6199609 -0.953357817 2.08E-10 4.42E-08 TIPARP ENSG00000163659 10128.62473 1.910352818 2.17E-10 4.59E-08 C16orf87 ENSG00000155330 1328.196908 0.711335512 2.37E-10 4.96E-08 SLC9A9 ENSG00000181804 2766.90961 0.752133271 2.39E-10 4.96E-08 TMEM160 ENSG00000130748 677.5780598 -1.198170968 2.54E-10 5.19E-08 RHOQ ENSG00000119729 3016.355571 0.972199655 2.89E-10 5.80E-08 BTBD6 ENSG00000184887 2474.016332 -0.972166178 3.29E-10 6.44E-08 IRF3 ENSG00000126456 7437.045012 -0.799046138 3.33E-10 6.47E-08 WASL ENSG00000106299 1162.093115 1.007692153 3.35E-10 6.47E-08 KLHL2 ENSG00000109466 5475.682458 1.263845551 4.29E-10 7.97E-08 METRN ENSG00000103260 152.9359759 -1.624443014 4.53E-10 8.26E-08 C19orf25 ENSG00000119559 921.1451089 -1.067978445 4.55E-10 8.26E-08

VDAC2 ENSG00000165637 5434.384578 0.472315014 4.97E-10 8.96E-08 GRASP ENSG00000161835 6338.433738 2.014064548 5.28E-10 9.39E-08 LIN7A ENSG00000111052 2935.436101 1.463029239 5.36E-10 9.41E-08 C9orf142 ENSG00000148362 2604.903607 -1.0056639 5.37E-10 9.41E-08 SDC3 ENSG00000162512 1106.951674 1.597239789 5.44E-10 9.46E-08 P3H4 ENSG00000141696 193.248591 -1.439442099 5.62E-10 9.71E-08 ETS2 ENSG00000157557 16327.64342 1.816719443 5.98E-10 1.01E-07 SYN1 ENSG00000008056 185.9150839 2.301083045 6.51E-10 1.09E-07 RNF141 ENSG00000110315 9502.018601 0.969767974 6.86E-10 1.14E-07 CRELD1 ENSG00000163703 1518.573635 -0.8348632 7.11E-10 1.16E-07 CEP170 ENSG00000143702 4684.280114 1.031624843 7.23E-10 1.17E-07 USP3 ENSG00000140455 16821.76071 0.739851912 7.58E-10 1.22E-07 NLRP3 ENSG00000162711 8480.092631 1.237744967 8.68E-10 1.38E-07 ADAM9 ENSG00000168615 3019.460901 1.269303787 9.39E-10 1.47E-07 CNTLN ENSG00000044459 957.478772 1.258034841 9.61E-10 1.49E-07 FBXW5 ENSG00000159069 7286.246545 -0.641909365 9.88E-10 1.53E-07 S100A12 ENSG00000163221 25503.60611 1.827084522 1.01E-09 1.53E-07 WDCP ENSG00000163026 475.1972989 -1.043627288 1.00E-09 1.53E-07 ADCK5 ENSG00000173137 761.8774118 -0.814091853 1.02E-09 1.54E-07 MEGF9 ENSG00000106780 23768.72752 2.100779945 1.06E-09 1.59E-07 STK11 ENSG00000118046 4827.129421 -0.739298389 1.08E-09 1.61E-07 GIPC1 ENSG00000123159 1517.538616 -1.066812133 1.09E-09 1.61E-07 FOXO3 ENSG00000118689 10521.13852 1.471713309 1.37E-09 1.99E-07 MON1A ENSG00000164077 528.7249492 -1.252138092 1.45E-09 2.08E-07 GRK3 ENSG00000100077 6767.08533 0.910712249 1.46E-09 2.08E-07 BRD8 ENSG00000112983 3099.0821 -0.53612752 1.50E-09 2.12E-07 FAM20A ENSG00000108950 901.5427004 2.597303327 1.55E-09 2.16E-07 ETV6 ENSG00000139083 11017.45091 0.685388492 1.55E-09 2.16E-07 TOP3B ENSG00000100038 2391.267949 -0.52775512 1.58E-09 2.19E-07 PDK4 ENSG00000004799 5702.10395 1.847990355 1.64E-09 2.26E-07 PICALM ENSG00000073921 27076.86933 0.859272501 1.77E-09 2.41E-07 CTC-529I10.2 ENSG00000227782 208.9428977 1.397372669 1.81E-09 2.45E-07 IRAK3 ENSG00000090376 13314.26197 1.619530594 1.84E-09 2.47E-07 ECHDC3 ENSG00000134463 1257.516736 1.92338095 1.95E-09 2.60E-07 ZNF575 ENSG00000176472 136.7790237 -1.07589261 1.97E-09 2.60E-07 SH2B1 ENSG00000178188 5445.077622 -0.57162 1.99E-09 2.62E-07 LRFN3 ENSG00000126243 325.3606102 -1.456743864 2.02E-09 2.64E-07 PKD2L2 ENSG00000078795 754.9648463 0.836944555 2.07E-09 2.68E-07 TMEM39A ENSG00000176142 3264.173919 0.956083932 2.14E-09 2.75E-07 YPEL2 ENSG00000175155 2554.837613 2.186323875 2.60E-09 3.17E-07 DYSF ENSG00000135636 21036.77997 1.410346857 2.61E-09 3.17E-07 PTRH1 ENSG00000187024 191.8377191 -1.142592914 2.59E-09 3.17E-07 PDCD7 ENSG00000090470 1733.265817 -0.745780438 2.56E-09 3.17E-07 CDK10 ENSG00000185324 4298.93524 -0.685370308 2.60E-09 3.17E-07 C18orf25 ENSG00000152242 5246.961119 0.758104477 2.59E-09 3.17E-07 CHN2 ENSG00000106069 2937.100226 0.925404665 2.85E-09 3.42E-07

ITGA9 ENSG00000144668 444.2397385 2.088531786 3.02E-09 3.59E-07 IL10 ENSG00000136634 351.2168893 2.642560426 3.09E-09 3.65E-07 MAPK6 ENSG00000069956 3538.457956 1.024751582 3.15E-09 3.69E-07 TMEM161A ENSG00000064545 657.3291937 -0.882295642 3.28E-09 3.82E-07 SPRYD7 ENSG00000123178 420.2304916 -0.615457731 3.45E-09 3.96E-07 NMD3 ENSG00000169251 3548.474244 0.657926124 3.62E-09 4.14E-07 DNAAF2 ENSG00000165506 521.3135804 -0.952598601 3.69E-09 4.20E-07 UBE2E1 ENSG00000170142 7077.968911 0.527062638 3.71E-09 4.21E-07 PRX ENSG00000105227 418.9355699 -0.848185642 3.74E-09 4.22E-07 PIGA ENSG00000165195 2873.784052 0.802123076 3.91E-09 4.39E-07 MEF2A ENSG00000068305 8221.346043 1.157661531 4.10E-09 4.57E-07 NPRL2 ENSG00000114388 2081.1295 -0.756259933 4.39E-09 4.84E-07 CCDC102A ENSG00000135736 475.4756844 -1.365704846 4.58E-09 4.96E-07 FAM78A ENSG00000126882 11124.945 -0.687093612 5.23E-09 5.61E-07 WASF1 ENSG00000112290 355.1423751 1.179595444 5.34E-09 5.71E-07 ZNF582 ENSG00000018869 192.5974795 -0.977154116 5.68E-09 6.03E-07 TTC22 ENSG00000006555 1069.436907 -1.414116067 5.69E-09 6.03E-07 SLC1A2 ENSG00000110436 25.11972599 2.437039249 6.00E-09 6.34E-07 PABPC1 ENSG00000070756 99765.818 0.383950209 6.26E-09 6.47E-07 SREK1 ENSG00000153914 9740.079959 0.74476752 6.30E-09 6.49E-07 CCM2 ENSG00000136280 7351.624803 -0.707221083 6.57E-09 6.73E-07 LCORL ENSG00000178177 2140.66714 0.798797808 6.66E-09 6.80E-07 JMJD1C ENSG00000171988 16804.41389 1.166982995 6.78E-09 6.89E-07 KIF5B ENSG00000170759 11679.39344 0.59336151 7.21E-09 7.24E-07 UBASH3B ENSG00000154127 3858.34223 0.73033175 7.54E-09 7.48E-07 SERPINB1 ENSG00000021355 30648.51902 1.064795354 7.68E-09 7.55E-07 HNRNPD ENSG00000138668 26097.59874 0.447333215 8.11E-09 7.94E-07 PTP4A1 ENSG00000112245 9248.44572 0.714038101 8.18E-09 7.99E-07 CERS6 ENSG00000172292 5064.119423 0.830052156 8.44E-09 8.18E-07 MS4A4A ENSG00000110079 1190.723991 1.727828464 9.12E-09 8.77E-07 APLP2 ENSG00000084234 80767.40462 1.043229321 1.04E-08 9.94E-07 TBC1D17 ENSG00000104946 3899.003774 -0.726621358 1.15E-08 1.09E-06 ST14 ENSG00000149418 5646.502663 1.310674922 1.19E-08 1.12E-06 PKD2L1 ENSG00000107593 85.99219265 2.255446473 1.20E-08 1.12E-06 TFAP2E ENSG00000116819 1176.404864 -0.73637617 1.31E-08 1.22E-06 CSDE1 ENSG00000009307 43185.79081 0.431347022 1.46E-08 1.32E-06 BOP1 ENSG00000261236 2252.685088 -0.737554155 1.46E-08 1.32E-06 BCOR ENSG00000183337 2998.565806 -0.752075827 1.54E-08 1.37E-06 PGD ENSG00000142657 35466.6159 1.029676756 1.59E-08 1.40E-06 R3HCC1L ENSG00000166024 3837.367773 0.63650985 1.60E-08 1.40E-06 MAP3K1 ENSG00000095015 23555.54208 0.852850957 1.65E-08 1.43E-06 ALCAM ENSG00000170017 2853.033564 1.074419478 1.76E-08 1.52E-06 BOLA1 ENSG00000178096 240.4428945 -1.14211661 1.87E-08 1.61E-06 METTL26 ENSG00000130731 1296.07745 -0.799206637 1.92E-08 1.65E-06 SAMSN1 ENSG00000155307 13096.34762 1.5327797 1.95E-08 1.65E-06 ITGAM ENSG00000169896 44015.29624 0.889311464 1.95E-08 1.65E-06

PITPNM1 ENSG00000110697 9615.045656 -0.643025922 1.94E-08 1.65E-06 RSL24D1 ENSG00000137876 9058.760462 0.43834218 2.09E-08 1.74E-06 FANCE ENSG00000112039 497.8766401 -1.108400922 2.19E-08 1.81E-06 C5orf66 ENSG00000224186 127.012401 1.343355644 2.21E-08 1.82E-06 C9orf72 ENSG00000147894 16622.32867 1.030516651 2.22E-08 1.82E-06 OLIG1 ENSG00000184221 487.3432774 -1.590968789 2.25E-08 1.83E-06 ASAP1 ENSG00000153317 10639.82351 0.923635696 2.25E-08 1.83E-06 RGS3 ENSG00000138835 3480.638546 -0.943591613 2.30E-08 1.85E-06 HDAC6 ENSG00000094631 5470.688056 -0.361955131 2.31E-08 1.86E-06 TMEM102 ENSG00000181284 578.9733277 -0.939546796 2.32E-08 1.86E-06 RLF ENSG00000117000 6673.366255 0.956703554 2.37E-08 1.89E-06 DMXL2 ENSG00000104093 18306.32674 1.056918321 2.41E-08 1.91E-06 TDRD9 ENSG00000156414 1649.944842 1.415853446 2.51E-08 1.97E-06 BCL3 ENSG00000069399 6840.643458 1.314003913 2.51E-08 1.97E-06 MTG2 ENSG00000101181 2041.700229 -0.716595994 2.54E-08 1.98E-06 FNDC3B ENSG00000075420 4453.075661 0.970346408 2.57E-08 2.00E-06 CENPT ENSG00000102901 3899.828758 -0.687289279 2.63E-08 2.04E-06 C1QB ENSG00000173369 1074.882015 1.926568575 2.82E-08 2.15E-06 UBE2D1 ENSG00000072401 6398.908984 1.082066752 2.82E-08 2.15E-06 SH2D3C ENSG00000095370 5367.965003 -0.686238964 2.88E-08 2.18E-06 RAPGEF2 ENSG00000109756 5230.769559 1.018066968 2.95E-08 2.21E-06 CUL5 ENSG00000166266 2676.653599 0.793371648 3.12E-08 2.32E-06 LBH ENSG00000213626 9001.542631 -1.253984598 3.12E-08 2.32E-06 RPRD1A ENSG00000141425 2690.204322 0.712264237 3.22E-08 2.36E-06 LRRC45 ENSG00000169683 1222.744897 -0.688770113 3.21E-08 2.36E-06 NCDN ENSG00000020129 1432.879616 -0.671581091 3.26E-08 2.37E-06 RSG1 ENSG00000132881 122.7246039 -1.298906323 3.32E-08 2.41E-06 SCRIB ENSG00000180900 4161.651427 -0.688769287 3.36E-08 2.41E-06 COMTD1 ENSG00000165644 539.1480233 -0.765137733 3.45E-08 2.47E-06 RASA1 ENSG00000145715 5578.19896 0.691815165 3.52E-08 2.50E-06 JDP2 ENSG00000140044 7246.998793 1.660994041 3.56E-08 2.51E-06 RNASE2 ENSG00000169385 6149.407374 1.954040743 3.63E-08 2.55E-06 SPHK2 ENSG00000063176 1004.745109 -0.591617767 3.65E-08 2.55E-06 ZMYM2 ENSG00000121741 10989.50937 0.619974958 4.10E-08 2.80E-06 FAM83G ENSG00000188522 600.7572908 -1.317526621 4.15E-08 2.83E-06 LIN7B ENSG00000104863 244.2956163 -0.848292921 4.36E-08 2.95E-06 RASGEF1B ENSG00000138670 2839.688547 1.273997742 4.38E-08 2.95E-06 RNGTT ENSG00000111880 2297.867289 0.843587658 4.54E-08 3.04E-06 FGD4 ENSG00000139132 4713.540595 1.394932807 4.62E-08 3.07E-06 RPAP1 ENSG00000103932 1565.517073 -0.537717179 4.61E-08 3.07E-06 CCNL1 ENSG00000163660 37858.59272 0.751819869 4.67E-08 3.10E-06 VAV3 ENSG00000134215 6042.711681 0.713322561 5.13E-08 3.38E-06 KYNU ENSG00000115919 5643.097619 1.394834055 5.17E-08 3.39E-06 P2RY1 ENSG00000169860 1203.678948 1.889237919 5.19E-08 3.40E-06 SOCS3 ENSG00000184557 12832.06625 1.595288408 5.32E-08 3.47E-06 MUM1 ENSG00000160953 1817.793466 -0.612574766 5.54E-08 3.58E-06

FBN2 ENSG00000138829 1820.449063 1.320096673 5.78E-08 3.71E-06 CPD ENSG00000108582 12356.43904 1.081957194 6.08E-08 3.88E-06 ELMO1 ENSG00000155849 4587.497366 0.534680231 6.14E-08 3.90E-06 IFNGR1 ENSG00000027697 24048.38574 1.323404496 6.16E-08 3.90E-06 GIMAP6 ENSG00000133561 6443.764161 -1.10963806 6.18E-08 3.90E-06 ATP5D ENSG00000099624 1745.236057 -0.875419834 6.23E-08 3.93E-06 CTNNB1 ENSG00000168036 14713.6577 0.684006209 6.25E-08 3.93E-06 HDAC8 ENSG00000147099 1174.641914 0.522979453 6.36E-08 3.98E-06 CPT1A ENSG00000110090 11906.30926 0.658699568 6.51E-08 4.05E-06 MEX3D ENSG00000181588 126.9948975 -1.164212331 6.74E-08 4.17E-06 AREG ENSG00000109321 3038.187715 2.339832778 6.76E-08 4.17E-06 MED11 ENSG00000161920 862.6892587 -0.846376808 6.89E-08 4.22E-06 MTMR10 ENSG00000166912 5900.07399 0.648178717 6.99E-08 4.27E-06 C19orf70 ENSG00000174917 1196.583324 -1.016330918 7.09E-08 4.31E-06 RIT1 ENSG00000143622 5835.620764 1.146188622 7.16E-08 4.33E-06 FBXW7 ENSG00000109670 6594.037971 0.56757608 7.46E-08 4.49E-06 IL16 ENSG00000172349 13253.70563 -0.694297391 7.48E-08 4.49E-06 UBE2R2 ENSG00000107341 11157.78419 0.699612984 7.66E-08 4.57E-06 PUSL1 ENSG00000169972 578.0466405 -0.757984838 7.78E-08 4.63E-06 HGH1 ENSG00000235173 365.6423775 -1.04510165 7.93E-08 4.70E-06 BOD1 ENSG00000145919 915.4450873 -0.641725895 8.06E-08 4.75E-06 TFRC ENSG00000072274 7034.791707 0.858757643 8.28E-08 4.87E-06 ENY2 ENSG00000120533 5406.564344 0.507123433 8.45E-08 4.94E-06 SMNDC1 ENSG00000119953 4078.374311 0.668878054 8.56E-08 4.99E-06 XYLT2 ENSG00000015532 2275.067523 -0.710057132 8.88E-08 5.16E-06 PTP4A3 ENSG00000184489 1289.818517 -1.056178745 8.91E-08 5.16E-06 PRPF19 ENSG00000110107 4987.150117 -0.59769231 9.10E-08 5.24E-06 SNX13 ENSG00000071189 3497.859822 0.770917185 9.21E-08 5.28E-06 MYO7A ENSG00000137474 1672.675008 1.775678273 9.63E-08 5.47E-06 KL ENSG00000133116 111.1416006 1.527242048 9.62E-08 5.47E-06 CPQ ENSG00000104324 5295.34867 0.786671999 9.72E-08 5.50E-06 C11orf21 ENSG00000110665 9036.142585 -0.783512636 9.75E-08 5.51E-06 ZNF232 ENSG00000167840 323.2076495 -0.973446904 9.81E-08 5.53E-06 LPAR5 ENSG00000184574 410.2969063 -0.997931921 9.93E-08 5.55E-06 AGFG2 ENSG00000106351 970.2054698 -1.132925487 1.01E-07 5.63E-06 PELI2 ENSG00000139946 5610.316665 0.910665556 1.05E-07 5.80E-06 DENND1A ENSG00000119522 6367.3556 0.632408447 1.07E-07 5.85E-06 RPP25L ENSG00000164967 551.7060335 -1.087541854 1.07E-07 5.85E-06 JRKL ENSG00000183340 651.7616396 -1.071582376 1.08E-07 5.92E-06 MFSD14A ENSG00000156875 7076.031769 0.662995442 1.09E-07 5.94E-06 L3MBTL2 ENSG00000100395 3195.31503 -0.581500403 1.09E-07 5.94E-06 NUDT4 ENSG00000173598 3670.735625 1.127234237 1.11E-07 6.02E-06 GPR68 ENSG00000119714 602.250531 -1.187093665 1.12E-07 6.04E-06 TNFRSF21 ENSG00000146072 495.5027524 1.513617406 1.14E-07 6.13E-06 CSGALNACT2 ENSG00000169826 24231.33581 1.161590342 1.16E-07 6.21E-06 MET ENSG00000105976 90.64930983 -2.342604425 1.17E-07 6.24E-06

NCSTN ENSG00000162736 14216.249 0.556941696 1.22E-07 6.41E-06 EDC3 ENSG00000179151 1760.51893 -0.641940803 1.22E-07 6.42E-06 IGSF8 ENSG00000162729 1783.572536 -0.976145751 1.23E-07 6.45E-06 SCAP ENSG00000114650 5992.73779 -0.456476872 1.26E-07 6.55E-06 TBKBP1 ENSG00000198933 2278.431277 -1.060503673 1.28E-07 6.64E-06 PNMA1 ENSG00000176903 1749.981108 -0.721258257 1.29E-07 6.67E-06 PPTC7 ENSG00000196850 9009.762346 0.512849897 1.30E-07 6.67E-06 CDYL2 ENSG00000166446 1831.822324 0.959934817 1.31E-07 6.70E-06 CHIC2 ENSG00000109220 3105.167849 0.934771209 1.34E-07 6.84E-06 ZNF837 ENSG00000152475 109.1123965 -1.388574462 1.37E-07 6.97E-06 RTN4R ENSG00000040608 59.25130968 -1.925773991 1.37E-07 6.97E-06 SPTLC1 ENSG00000090054 4004.464562 0.676778568 1.37E-07 6.97E-06 CDK4 ENSG00000135446 1450.182282 -0.909780559 1.39E-07 7.03E-06 HSPB1 ENSG00000106211 1226.813158 -1.069334841 1.39E-07 7.03E-06 COPS7B ENSG00000144524 3246.86659 -0.401941164 1.40E-07 7.05E-06 DNAJB2 ENSG00000135924 3055.575702 -0.705384924 1.43E-07 7.20E-06 KDM6A ENSG00000147050 5780.294181 0.965805216 1.43E-07 7.20E-06 MED16 ENSG00000175221 2833.243127 -0.54171689 1.44E-07 7.22E-06 AGFG1 ENSG00000173744 10380.48426 1.688119033 1.45E-07 7.28E-06 KIAA0922 ENSG00000121210 10933.65502 0.626966505 1.50E-07 7.49E-06 LSS ENSG00000160285 2845.678653 -0.747962428 1.50E-07 7.49E-06 ADIPOR1 ENSG00000159346 17055.39624 0.926524576 1.53E-07 7.55E-06 FBXL15 ENSG00000107872 812.5922566 -0.9890541 1.53E-07 7.55E-06 ARL5B ENSG00000165997 4404.235891 1.055577185 1.53E-07 7.55E-06 ASCL2 ENSG00000183734 530.2746839 -1.346922166 1.55E-07 7.63E-06 ARHGAP24 ENSG00000138639 2367.686484 1.384797189 1.57E-07 7.72E-06 MAP3K10 ENSG00000130758 1358.87581 -0.767896142 1.62E-07 7.92E-06 LPCAT4 ENSG00000176454 2546.697178 -0.724959473 1.63E-07 7.97E-06 CHCHD10 ENSG00000250479 1046.017192 -0.742800089 1.65E-07 8.04E-06 MYO5A ENSG00000197535 9949.87664 0.659350329 1.67E-07 8.13E-06 FBP1 ENSG00000165140 5627.422881 1.151973311 1.70E-07 8.25E-06 RPL39L ENSG00000163923 135.9192732 -1.24876741 1.71E-07 8.29E-06 RAI1 ENSG00000108557 2287.078865 -0.598454435 1.74E-07 8.40E-06 BROX ENSG00000162819 5657.784632 0.588684104 1.75E-07 8.44E-06 PTDSS2 ENSG00000174915 1344.509102 -0.505906182 1.79E-07 8.60E-06 C15orf40 ENSG00000169609 1016.880925 -0.518269003 1.79E-07 8.60E-06 PDS5B ENSG00000083642 3331.19691 0.725514234 1.85E-07 8.82E-06 GDF11 ENSG00000135414 938.2570218 -0.935200829 1.85E-07 8.82E-06 GPER1 ENSG00000164850 459.2001017 1.673109416 1.87E-07 8.86E-06 PLSCR1 ENSG00000188313 9276.485118 1.084217706 1.86E-07 8.86E-06 TMEM167B ENSG00000215717 8897.463326 0.783395125 1.89E-07 8.95E-06 THBD ENSG00000178726 3004.132137 1.73732192 1.97E-07 9.29E-06 SRPK1 ENSG00000096063 5409.166869 0.837988325 2.05E-07 9.61E-06 PTPN2 ENSG00000175354 6921.548416 0.46320114 2.08E-07 9.70E-06 CD93 ENSG00000125810 29542.20177 1.048022506 2.08E-07 9.70E-06 LAGE3 ENSG00000196976 449.5296307 -0.974403989 2.09E-07 9.73E-06

ZNF853 ENSG00000236609 445.6312186 -1.159589166 2.10E-07 9.75E-06 CDKN1C ENSG00000129757 624.5900654 -1.60135368 2.10E-07 9.75E-06 PLD1 ENSG00000075651 105.6287747 1.480892279 2.17E-07 1.00E-05 SP3 ENSG00000172845 12601.23125 0.842703364 2.17E-07 1.00E-05 TMEM129 ENSG00000168936 2182.862274 -0.716047368 2.19E-07 1.01E-05 HERPUD1 ENSG00000051108 10981.58706 0.833770716 2.19E-07 1.01E-05 ACTR1B ENSG00000115073 4336.078502 -0.504694295 2.21E-07 1.02E-05 RNF144B ENSG00000137393 13815.67749 1.378711303 2.26E-07 1.03E-05 ZNF80 ENSG00000174255 253.2241999 -1.497719437 2.35E-07 1.07E-05 ACSL3 ENSG00000123983 3294.580623 0.742837031 2.36E-07 1.07E-05 FKBP5 ENSG00000096060 21087.11096 1.345031498 2.39E-07 1.08E-05 ICAM1 ENSG00000090339 7032.649987 1.298948989 2.40E-07 1.08E-05 DOLPP1 ENSG00000167130 637.443098 -0.673108183 2.42E-07 1.09E-05 FAM49B ENSG00000153310 18592.32804 0.588625671 2.45E-07 1.10E-05 PLAA ENSG00000137055 3099.683357 0.62924934 2.48E-07 1.11E-05 FAM200A ENSG00000221909 300.2736309 -0.903999345 2.56E-07 1.14E-05 RAD9A ENSG00000172613 2048.520289 -0.786815581 2.62E-07 1.17E-05 PIEZO1 ENSG00000103335 14552.09494 -0.596781089 2.64E-07 1.17E-05 SEC24B ENSG00000138802 5557.296141 0.804819691 2.67E-07 1.18E-05 GRB10 ENSG00000106070 2086.55778 1.764675874 2.66E-07 1.18E-05 SLC29A2 ENSG00000174669 484.4328536 -1.064890833 2.71E-07 1.19E-05 GNA13 ENSG00000120063 20431.54936 0.742951239 2.71E-07 1.19E-05 RAB39A ENSG00000179331 275.6781892 1.302975681 2.75E-07 1.21E-05 FAM50B ENSG00000145945 195.5723056 -1.117312002 2.76E-07 1.21E-05 POLRMT ENSG00000099821 3872.740131 -0.770537001 2.76E-07 1.21E-05 ATG4B ENSG00000168397 4699.614927 -0.524028361 2.77E-07 1.21E-05 SNRPA1 ENSG00000131876 4939.604581 0.707906689 2.78E-07 1.21E-05 STK25 ENSG00000115694 5104.944367 -0.508809179 2.81E-07 1.22E-05 EHMT2 ENSG00000204371 4494.395392 -0.564755688 2.82E-07 1.22E-05 GAS7 ENSG00000007237 21718.49789 1.023684968 2.88E-07 1.24E-05 MPP5 ENSG00000072415 1292.891252 0.671972025 2.94E-07 1.27E-05 NFIL3 ENSG00000165030 9295.400499 1.381823628 2.97E-07 1.28E-05 FBXO48 ENSG00000204923 410.0723412 -0.79536815 3.00E-07 1.29E-05 RARS2 ENSG00000146282 3584.744127 0.357963166 3.01E-07 1.29E-05 GLUL ENSG00000135821 50162.04644 1.089584785 3.12E-07 1.34E-05 LAMP2 ENSG00000005893 13933.62695 0.792404864 3.13E-07 1.34E-05 TRADD ENSG00000102871 3642.619809 -0.757260385 3.14E-07 1.34E-05 DVL2 ENSG00000004975 2046.975448 -0.578296302 3.19E-07 1.35E-05 SLC35A3 ENSG00000117620 3072.367357 0.969844222 3.23E-07 1.37E-05 RALGDS ENSG00000160271 9744.798253 -0.830984371 3.25E-07 1.38E-05 CLIC4 ENSG00000169504 4406.315096 0.89838357 3.29E-07 1.39E-05 ZFHX3 ENSG00000140836 2641.442018 1.16212638 3.33E-07 1.40E-05 PLD4 ENSG00000166428 1250.918853 -1.418027714 3.35E-07 1.41E-05 CCDC85B ENSG00000175602 1337.880759 -1.127571421 3.38E-07 1.42E-05 SHARPIN ENSG00000179526 2314.527806 -0.594270026 3.50E-07 1.46E-05 S100A9 ENSG00000163220 349390.342 1.29985473 3.50E-07 1.46E-05

SLC16A6 ENSG00000108932 3972.388764 1.244398409 3.52E-07 1.46E-05 VCAN ENSG00000038427 89139.30586 1.146154561 3.55E-07 1.47E-05 ZNHIT2 ENSG00000174276 266.81665 -0.852960498 3.66E-07 1.51E-05 FANCF ENSG00000183161 796.641865 -0.747833973 3.66E-07 1.51E-05 STOML1 ENSG00000067221 422.9480372 -0.928920116 3.71E-07 1.52E-05 DNAJC2 ENSG00000105821 4017.809775 0.493329809 3.80E-07 1.55E-05 BCLAF1 ENSG00000029363 15341.14549 0.732158882 3.81E-07 1.56E-05 ENDOG ENSG00000167136 262.27987 -1.134910243 3.83E-07 1.56E-05 CLIP1 ENSG00000130779 8168.001389 0.53131717 3.85E-07 1.57E-05 WDR81 ENSG00000167716 5737.531921 -0.66383594 3.92E-07 1.59E-05 ITSN2 ENSG00000198399 15498.16534 0.55855861 3.92E-07 1.59E-05 CXCL16 ENSG00000161921 6242.831842 1.01147701 3.94E-07 1.60E-05 RBMS1 ENSG00000153250 11003.03438 0.529410764 3.96E-07 1.60E-05 BCAT1 ENSG00000060982 1604.993957 1.569017868 4.08E-07 1.63E-05 AP1G1 ENSG00000166747 8183.323928 0.931034897 4.17E-07 1.67E-05 KIAA1958 ENSG00000165185 987.4178253 1.087265047 4.21E-07 1.68E-05 PPP1R3F ENSG00000049769 516.0064991 -0.856424433 4.28E-07 1.70E-05 PARP10 ENSG00000178685 6760.128729 -0.95975058 4.28E-07 1.70E-05 TELO2 ENSG00000100726 2439.012479 -0.60420994 4.37E-07 1.74E-05 GIMAP7 ENSG00000179144 5550.217205 -1.416086251 4.57E-07 1.80E-05 GADD45A ENSG00000116717 1549.300481 1.229965726 4.58E-07 1.81E-05 USP48 ENSG00000090686 11543.25453 0.486678976 4.69E-07 1.84E-05 SGTB ENSG00000197860 3648.16847 0.832475234 4.71E-07 1.85E-05 RINL ENSG00000187994 2277.678998 -0.846052504 4.87E-07 1.91E-05 KLHL15 ENSG00000174010 2132.399266 1.254684497 4.90E-07 1.92E-05 MAP3K8 ENSG00000107968 6477.405805 0.955227076 5.05E-07 1.97E-05 HEXIM1 ENSG00000186834 5341.809653 -0.40241513 5.09E-07 1.98E-05 SLC28A3 ENSG00000197506 320.5785793 1.886197567 5.16E-07 2.00E-05 C9orf16 ENSG00000171159 2799.888223 -0.808327037 5.33E-07 2.07E-05 SMAD1 ENSG00000170365 496.7934388 1.056617774 5.37E-07 2.08E-05 CHTF18 ENSG00000127586 1153.166005 -0.855161141 5.43E-07 2.09E-05 CES1 ENSG00000198848 6319.809477 1.70368713 5.42E-07 2.09E-05 RBM47 ENSG00000163694 5908.686707 1.028710219 5.41E-07 2.09E-05 ING4 ENSG00000111653 2109.540526 -0.554808941 5.43E-07 2.09E-05 ANGPTL6 ENSG00000130812 162.858089 -1.497484193 5.68E-07 2.17E-05 TGM2 ENSG00000198959 1332.903722 1.862426991 5.70E-07 2.18E-05 DPP7 ENSG00000176978 7462.292555 -0.688671906 5.77E-07 2.20E-05 S100A8 ENSG00000143546 110058.4603 1.398766742 5.86E-07 2.23E-05 PTPRE ENSG00000132334 29885.62848 0.95097511 5.89E-07 2.24E-05 PTBP2 ENSG00000117569 2524.887952 1.327736077 6.02E-07 2.27E-05 SRGN ENSG00000122862 116341.6546 1.05952705 6.06E-07 2.29E-05 BAG4 ENSG00000156735 1338.706692 0.726290739 6.11E-07 2.30E-05 PDGFB ENSG00000100311 281.9419712 -1.628238188 6.24E-07 2.33E-05 NAMPT ENSG00000105835 99624.28164 1.758612196 6.30E-07 2.35E-05 ANKRD13B ENSG00000198720 169.8159751 -1.011182145 6.38E-07 2.37E-05 TREML4 ENSG00000188056 483.0480803 1.709950312 6.37E-07 2.37E-05

DMXL1 ENSG00000172869 5540.835433 0.499234539 6.36E-07 2.37E-05 CEP250 ENSG00000126001 4939.332089 -0.838580373 6.40E-07 2.37E-05 RAB3GAP1 ENSG00000115839 3991.591094 0.602397278 6.44E-07 2.38E-05 PSMD6 ENSG00000163636 10541.67262 0.642093544 6.48E-07 2.39E-05 CAPN12 ENSG00000182472 344.759877 -0.954952818 6.55E-07 2.42E-05 EVI5 ENSG00000067208 2285.33787 0.915946944 6.73E-07 2.48E-05 MZT2A ENSG00000173272 1903.754317 -0.835563276 6.93E-07 2.55E-05 CFAP157 ENSG00000160401 38.85814445 -1.228264384 6.95E-07 2.55E-05 INO80E ENSG00000169592 3146.553041 -0.542061274 7.20E-07 2.62E-05 DNAJA2 ENSG00000069345 4648.131623 0.536979826 7.20E-07 2.62E-05 TMEM135 ENSG00000166575 869.5915058 1.146127003 7.43E-07 2.70E-05 SLC10A7 ENSG00000120519 801.2591802 0.689447104 8.03E-07 2.90E-05 H2AFY ENSG00000113648 27456.24331 0.824298395 8.04E-07 2.90E-05 PPP1R16A ENSG00000160972 771.2893148 -0.772163356 8.15E-07 2.93E-05 FAR1 ENSG00000197601 13071.18375 0.705204045 8.17E-07 2.94E-05 ICAM2 ENSG00000108622 3688.915717 -0.881978169 8.33E-07 2.99E-05 DIAPH2 ENSG00000147202 2948.432128 0.747026674 8.35E-07 2.99E-05 STIP1 ENSG00000168439 4601.896074 -0.519908111 8.46E-07 3.02E-05 RSRC2 ENSG00000111011 9497.257283 0.759033312 8.75E-07 3.09E-05 PMPCB ENSG00000105819 6157.772938 0.33934208 8.91E-07 3.14E-05 LRP1 ENSG00000123384 65797.35326 0.914206239 8.95E-07 3.14E-05 MED13 ENSG00000108510 8534.349808 0.597704281 9.12E-07 3.20E-05 MED13L ENSG00000123066 14027.57837 1.322203006 9.15E-07 3.20E-05 NUP58 ENSG00000139496 4433.659819 0.619478591 9.24E-07 3.23E-05 GPR84 ENSG00000139572 222.381556 1.438340021 9.25E-07 3.23E-05 B3GALT6 ENSG00000176022 1081.007914 -0.726918512 9.29E-07 3.24E-05 SNX2 ENSG00000205302 11163.96679 0.675460527 9.78E-07 3.39E-05 PPP2R2A ENSG00000221914 6091.231884 0.461167583 9.90E-07 3.43E-05 UBR2 ENSG00000024048 11925.2159 0.590382015 1.02E-06 3.52E-05 ADAM17 ENSG00000151694 7056.707824 0.875259684 1.03E-06 3.54E-05 HBP1 ENSG00000105856 7025.534844 0.93734793 1.03E-06 3.54E-05 RXRB ENSG00000204231 5378.903222 -0.444531057 1.03E-06 3.56E-05 TRAPPC6A ENSG00000007255 1101.099651 -0.842260131 1.05E-06 3.59E-05 QKI ENSG00000112531 5635.287262 1.022038437 1.05E-06 3.59E-05 SPOCK1 ENSG00000152377 317.9184602 1.094858738 1.05E-06 3.59E-05 SMIM3 ENSG00000256235 2688.245998 1.231096776 1.06E-06 3.61E-05 ZMYND19 ENSG00000165724 956.4146053 -0.723817478 1.09E-06 3.69E-05 MISP3 ENSG00000141854 117.3060687 -1.134051347 1.10E-06 3.70E-05 ZFP37 ENSG00000136866 119.5969943 -1.293205864 1.12E-06 3.76E-05 NAGS ENSG00000161653 62.56773612 -1.513177048 1.16E-06 3.88E-05 DAXX ENSG00000204209 3908.501907 -0.760072813 1.16E-06 3.90E-05 CUL3 ENSG00000036257 7632.745345 0.610055653 1.16E-06 3.90E-05 WNT5A ENSG00000114251 36.67905423 2.332290307 1.17E-06 3.90E-05 ACD ENSG00000102977 1159.424699 -0.793175865 1.17E-06 3.90E-05 CORO1A ENSG00000102879 74069.53488 -0.594684136 1.20E-06 3.98E-05 GNG4 ENSG00000168243 19.30779284 2.427298726 1.20E-06 3.98E-05

POMP ENSG00000132963 5046.912275 0.516314078 1.20E-06 3.98E-05 EXOC6 ENSG00000138190 1927.754268 0.755977598 1.23E-06 4.06E-05 SSBP4 ENSG00000130511 6616.858887 -0.710574929 1.25E-06 4.12E-05 PRMT7 ENSG00000132600 2387.210558 -0.569197807 1.28E-06 4.21E-05 YDJC ENSG00000161179 913.3136089 -0.951440693 1.31E-06 4.30E-05 B4GALT5 ENSG00000158470 9666.183903 1.068989654 1.33E-06 4.36E-05 AHDC1 ENSG00000126705 1424.646434 -0.791593154 1.34E-06 4.38E-05 TET2 ENSG00000168769 10676.38633 0.891957474 1.36E-06 4.45E-05 ETF1 ENSG00000120705 8243.059423 0.879984373 1.37E-06 4.46E-05 FN1 ENSG00000115414 736.3394648 1.936767036 1.38E-06 4.48E-05 TPRG1L ENSG00000158109 4404.142868 -0.507562241 1.39E-06 4.50E-05 SIT1 ENSG00000137078 811.4927776 -1.216754188 1.39E-06 4.50E-05 SMIM10 ENSG00000184785 73.67132612 1.679190213 1.39E-06 4.50E-05 STRN3 ENSG00000196792 2061.31535 0.67931252 1.40E-06 4.51E-05 IGFBP3 ENSG00000146674 468.2225629 -1.321704784 1.40E-06 4.52E-05 SIGIRR ENSG00000185187 8829.133772 -0.878429391 1.41E-06 4.53E-05 FAAP100 ENSG00000185504 3463.935132 -0.518921157 1.41E-06 4.53E-05 ZSWIM6 ENSG00000130449 5109.542035 0.928854013 1.43E-06 4.57E-05 TBL1XR1 ENSG00000177565 7199.256217 0.528941605 1.44E-06 4.60E-05 LYN ENSG00000254087 29050.94215 0.838448675 1.45E-06 4.62E-05 ERBB2 ENSG00000141736 1257.463856 -1.272813863 1.45E-06 4.62E-05 ROCK1 ENSG00000067900 12670.45202 0.796693894 1.47E-06 4.66E-05 ATPIF1 ENSG00000130770 3617.247712 -0.472880938 1.50E-06 4.77E-05 ILKAP ENSG00000132323 5486.719078 0.612440854 1.54E-06 4.88E-05 U2AF1 ENSG00000160201 9132.816929 0.791794881 1.55E-06 4.89E-05 TARS2 ENSG00000143374 1833.331389 -0.550704966 1.56E-06 4.91E-05 USP15 ENSG00000135655 30875.6165 0.723369139 1.61E-06 5.04E-05 SMG7 ENSG00000116698 9646.172637 0.549759717 1.61E-06 5.05E-05 MCRIP1 ENSG00000225663 1995.471139 -0.740477209 1.62E-06 5.07E-05 GYG1 ENSG00000163754 6085.749371 0.840182731 1.64E-06 5.11E-05 MID1IP1 ENSG00000165175 2799.655475 -0.882274779 1.66E-06 5.16E-05 ST6GALNAC3 ENSG00000184005 985.5735969 1.452815496 1.71E-06 5.29E-05 CYB561 ENSG00000008283 2036.195008 -0.986736126 1.74E-06 5.37E-05 TBC1D12 ENSG00000108239 842.0709453 1.149449257 1.77E-06 5.45E-05 METTL7B ENSG00000170439 94.45324491 2.376219685 1.77E-06 5.45E-05 VSIG4 ENSG00000155659 4118.295297 2.222504232 1.80E-06 5.51E-05 ENO2 ENSG00000111674 2327.167515 -0.919037951 1.86E-06 5.64E-05 SLC11A2 ENSG00000110911 3517.054748 0.576869954 1.86E-06 5.66E-05 CHST15 ENSG00000182022 16948.16163 0.944238707 1.90E-06 5.77E-05 RANBP9 ENSG00000010017 6137.775647 0.401132182 1.91E-06 5.78E-05 DOCK2 ENSG00000134516 36952.07116 0.462690227 1.91E-06 5.78E-05 EPHB6 ENSG00000106123 2275.052272 -0.582003509 1.92E-06 5.79E-05 VRK2 ENSG00000028116 3096.255186 0.622451337 1.95E-06 5.87E-05 ABCA3 ENSG00000167972 696.860035 -0.86288531 1.95E-06 5.88E-05 MRPL57 ENSG00000173141 1385.289616 -0.522731854 1.97E-06 5.94E-05 SLC39A4 ENSG00000147804 288.3546412 -0.838986503 2.03E-06 6.09E-05

GALC ENSG00000054983 5384.868654 0.679373977 2.03E-06 6.09E-05 EXT1 ENSG00000182197 2250.463288 0.710289507 2.07E-06 6.18E-05 DVL1 ENSG00000107404 2453.971677 -0.646133358 2.07E-06 6.18E-05 UBE2N ENSG00000177889 5601.004074 0.402134505 2.08E-06 6.19E-05 C1orf122 ENSG00000197982 841.9750336 -0.687481027 2.09E-06 6.22E-05 TMEM229B ENSG00000198133 1644.623346 -0.932451337 2.09E-06 6.23E-05 OPA1 ENSG00000198836 5625.661482 0.552331606 2.11E-06 6.24E-05 TRMT61A ENSG00000166166 866.2120987 -0.794247452 2.11E-06 6.24E-05 RAB13 ENSG00000143545 910.612712 1.476199291 2.11E-06 6.24E-05 SMCO4 ENSG00000166002 1776.015862 0.864888486 2.12E-06 6.27E-05 ARHGEF19 ENSG00000142632 910.9356328 -0.799653294 2.12E-06 6.27E-05 LZTS2 ENSG00000107816 1658.2498 -0.655194407 2.14E-06 6.30E-05 KRI1 ENSG00000129347 4890.922433 -0.570805771 2.14E-06 6.30E-05 GPS1 ENSG00000169727 5176.247418 -0.426635743 2.18E-06 6.35E-05 THEMIS2 ENSG00000130775 31883.22953 0.854321128 2.24E-06 6.53E-05 LTA4H ENSG00000111144 36762.45171 1.017463339 2.26E-06 6.56E-05 JARID2 ENSG00000008083 10912.2392 1.022005672 2.30E-06 6.67E-05 CALHM2 ENSG00000138172 2642.911164 -1.147454194 2.33E-06 6.75E-05 CPEB2 ENSG00000137449 2009.462823 1.298025709 2.35E-06 6.80E-05 PP2D1 ENSG00000183977 339.1254432 0.8309882 2.36E-06 6.83E-05 FAM160B2 ENSG00000158863 5107.083524 -0.611452064 2.37E-06 6.85E-05 MTHFD2 ENSG00000065911 4111.260144 0.742550359 2.40E-06 6.90E-05 SORCS2 ENSG00000184985 639.9006979 1.2146051 2.42E-06 6.96E-05 TSC2 ENSG00000103197 8299.01098 -0.386857864 2.49E-06 7.11E-05 ARMC5 ENSG00000140691 706.3246122 -0.870016782 2.50E-06 7.14E-05 POMGNT1 ENSG00000085998 2183.673951 -0.545918743 2.51E-06 7.16E-05 SMPDL3A ENSG00000172594 1698.559984 1.057673332 2.54E-06 7.20E-05 SOAT1 ENSG00000057252 7693.509252 0.728572079 2.53E-06 7.20E-05 SCPEP1 ENSG00000121064 14129.77362 0.782823748 2.54E-06 7.20E-05 NDUFAF5 ENSG00000101247 1392.257473 0.964547764 2.55E-06 7.22E-05 HIPK2 ENSG00000064393 11697.14035 0.846763006 2.57E-06 7.28E-05 PTMS ENSG00000159335 703.9640361 -0.907616435 2.60E-06 7.35E-05 FLAD1 ENSG00000160688 2179.629905 -0.608961154 2.62E-06 7.38E-05 FAM183BP ENSG00000164556 176.8397116 1.484916125 2.72E-06 7.63E-05 EAF1 ENSG00000144597 2172.302073 1.19166773 2.73E-06 7.65E-05 EXD3 ENSG00000187609 1072.040443 -0.680585943 2.74E-06 7.65E-05 DDX23 ENSG00000174243 7255.296753 -0.44192838 2.76E-06 7.71E-05 SYAP1 ENSG00000169895 5407.215832 1.021885735 2.82E-06 7.85E-05 ABHD15 ENSG00000168792 2542.967759 -0.688051386 2.84E-06 7.88E-05 BBC3 ENSG00000105327 792.6797811 -0.977495985 2.89E-06 8.01E-05 COQ10B ENSG00000115520 2330.649257 0.950943162 2.94E-06 8.13E-05 TMEM238 ENSG00000233493 44.52950029 -2.167057592 2.99E-06 8.25E-05 CLEC7A ENSG00000172243 17284.64376 1.226837585 3.00E-06 8.27E-05 UBR3 ENSG00000144357 2757.642626 0.610343032 3.04E-06 8.36E-05 KIAA1468 ENSG00000134444 7059.973512 0.456349488 3.07E-06 8.41E-05 ZNF692 ENSG00000171163 2105.279693 -0.803844879 3.12E-06 8.55E-05

ZCCHC6 ENSG00000083223 15579.38881 0.79113169 3.13E-06 8.56E-05 PSKH1 ENSG00000159792 2035.172761 -0.532997938 3.14E-06 8.58E-05 ACTL10 ENSG00000182584 59.40847066 -1.74515868 3.15E-06 8.59E-05 CLIC3 ENSG00000169583 1013.517736 -1.399706893 3.20E-06 8.72E-05 ABI1 ENSG00000136754 14613.82615 0.533291484 3.21E-06 8.72E-05 C1orf74 ENSG00000162757 732.2745594 -1.129750615 3.21E-06 8.72E-05 B3GNT5 ENSG00000176597 2109.766386 1.408930645 3.22E-06 8.72E-05 ZDHHC8 ENSG00000099904 2512.568302 -0.67816568 3.21E-06 8.72E-05 CCDC88A ENSG00000115355 6793.760027 0.924664464 3.22E-06 8.72E-05 SLC24A4 ENSG00000140090 5900.849177 1.229520796 3.25E-06 8.79E-05 COTL1 ENSG00000103187 85749.86666 0.683215824 3.31E-06 8.92E-05 ANKMY1 ENSG00000144504 2742.996001 -0.561430246 3.33E-06 8.98E-05 IPO13 ENSG00000117408 2026.322602 -0.573873831 3.34E-06 8.99E-05 PAK4 ENSG00000130669 596.6223852 -0.616622031 3.36E-06 9.02E-05 TBC1D8 ENSG00000204634 5593.62073 0.868927312 3.37E-06 9.05E-05 SBF1 ENSG00000100241 14382.03341 -0.654816258 3.44E-06 9.20E-05 AHSA1 ENSG00000100591 4014.071152 -0.614596722 3.46E-06 9.24E-05 WDR59 ENSG00000103091 3174.7479 -0.344680753 3.47E-06 9.26E-05 LRRC40 ENSG00000066557 2010.775397 0.546633424 3.49E-06 9.29E-05 TIGD7 ENSG00000140993 593.7199884 -0.691180687 3.49E-06 9.29E-05 BBS10 ENSG00000179941 527.8713701 -0.897708507 3.54E-06 9.36E-05 BTG3 ENSG00000154640 1071.976537 0.949065204 3.53E-06 9.36E-05 TEF ENSG00000167074 538.7339677 -0.980149988 3.55E-06 9.38E-05 FAM91A1 ENSG00000176853 4544.977501 1.071969503 3.62E-06 9.54E-05 ABCA13 ENSG00000179869 991.1589821 2.10826267 3.66E-06 9.60E-05 GNA15 ENSG00000060558 3988.300413 0.930850999 3.66E-06 9.60E-05 INSR ENSG00000171105 2144.067867 0.88165792 3.66E-06 9.60E-05 PTGES ENSG00000148344 203.5036285 1.947257618 3.67E-06 9.61E-05 MPO ENSG00000005381 5561.236559 2.082785944 3.69E-06 9.67E-05 USP21 ENSG00000143258 2004.797157 -0.497469968 3.72E-06 9.71E-05 GCA ENSG00000115271 15435.51787 1.181871948 3.72E-06 9.71E-05 STX11 ENSG00000135604 16655.30104 0.924189348 3.73E-06 9.72E-05 CERS4 ENSG00000090661 1163.984814 -0.77924301 3.74E-06 9.75E-05 LYL1 ENSG00000104903 2172.711617 -0.832094659 3.77E-06 9.80E-05 COPA ENSG00000122218 16803.90297 0.470036775 3.79E-06 9.85E-05 SLC22A15 ENSG00000163393 4996.155303 1.017706759 3.83E-06 9.93E-05 NOG ENSG00000183691 133.9638414 -1.828750711 3.84E-06 9.94E-05 ARHGAP26 ENSG00000145819 12452.74694 0.960419922 3.87E-06 9.98E-05 TMEM187 ENSG00000177854 170.8474511 -1.13396263 3.87E-06 9.98E-05 USP20 ENSG00000136878 4424.048266 -0.602922032 3.96E-06 0.000101838 CCDC50 ENSG00000152492 5728.203679 0.871305271 3.98E-06 0.000102154 SLC26A11 ENSG00000181045 2046.868312 -0.784161641 4.01E-06 0.000102663 DNTTIP2 ENSG00000067334 6315.591181 0.658775134 4.02E-06 0.000102744 CPEB4 ENSG00000113742 3760.121563 1.158065754 4.14E-06 0.000105223 CRNKL1 ENSG00000101343 3028.777317 0.599633906 4.17E-06 0.000105848 COQ4 ENSG00000167113 2483.898498 -0.535801106 4.19E-06 0.000106367

CCDC157 ENSG00000187860 244.2461605 -0.863576524 4.21E-06 0.000106539 HMGXB4 ENSG00000100281 2450.776452 0.683071464 4.23E-06 0.00010664 RNF169 ENSG00000166439 5948.026983 0.892315364 4.29E-06 0.000107792 LMF2 ENSG00000100258 7800.272221 -0.755354869 4.35E-06 0.000109293 CCNY ENSG00000108100 13693.37447 0.533367574 4.46E-06 0.000111942 NCOA3 ENSG00000124151 9524.502542 0.825799863 4.48E-06 0.00011215 APEH ENSG00000164062 5420.015532 -0.524796541 4.53E-06 0.00011317 USP32 ENSG00000170832 7248.173128 0.725436521 4.54E-06 0.000113456 APRT ENSG00000198931 3821.022632 -0.66319774 4.66E-06 0.000116096 MMACHC ENSG00000132763 180.4758347 -1.011058756 4.68E-06 0.00011638 ERO1A ENSG00000197930 8663.098686 0.595742587 4.71E-06 0.000117012 EEFSEC ENSG00000132394 1498.411143 -0.473287416 4.80E-06 0.000118924 VIM ENSG00000026025 176313.3618 0.79992281 4.81E-06 0.000119037 RRAGB ENSG00000083750 1201.860412 0.397274961 4.83E-06 0.000119395 DUSP4 ENSG00000120875 794.2145556 1.705245935 4.83E-06 0.000119416 CNOT3 ENSG00000088038 4990.517811 -0.457026932 4.86E-06 0.00011994 CLTC ENSG00000141367 16692.59452 0.624254252 4.88E-06 0.000120386 ZNF771 ENSG00000179965 67.97187105 -1.04899058 4.92E-06 0.000121284 CALCRL ENSG00000064989 333.0042325 1.298192898 4.93E-06 0.000121305 CTSA ENSG00000064601 17830.99594 0.689871735 4.94E-06 0.00012131 SCAF4 ENSG00000156304 7416.139408 0.617809276 5.02E-06 0.000122823 KIAA0368 ENSG00000136813 8366.637356 0.418175525 5.01E-06 0.000122823 MRPS26 ENSG00000125901 1159.32588 -0.74453644 5.07E-06 0.000123942 TOM1 ENSG00000100284 11124.77315 0.852212367 5.08E-06 0.000123957 MARCH6 ENSG00000145495 12187.52901 0.661717662 5.10E-06 0.000124211 WRAP53 ENSG00000141499 877.2416138 -0.540396397 5.10E-06 0.000124211 TSSK6 ENSG00000178093 122.4543763 -0.636271304 5.10E-06 0.000124211 SEC63 ENSG00000025796 9324.265072 0.51209017 5.12E-06 0.000124592 AUH ENSG00000148090 4756.410789 0.62914955 5.14E-06 0.000124758 ANKZF1 ENSG00000163516 5613.236341 -0.476478942 5.16E-06 0.000125196 TEX30 ENSG00000151287 488.4399379 -0.547441438 5.18E-06 0.000125196 CFL2 ENSG00000165410 1215.986269 0.911631615 5.23E-06 0.000126336 LCK ENSG00000182866 13780.24846 -1.026196479 5.25E-06 0.000126688 FAM46A ENSG00000112773 5897.761006 1.126717154 5.31E-06 0.00012806 TAF5 ENSG00000148835 768.624609 -0.387677457 5.36E-06 0.000128997 RTKN ENSG00000114993 73.42393329 -1.064235902 5.46E-06 0.000131383 XXYLT1 ENSG00000173950 1723.24635 0.749068532 5.47E-06 0.000131473 ANTXR2 ENSG00000163297 5389.718667 0.933674145 5.50E-06 0.000131786 PARD6A ENSG00000102981 193.3010841 -0.864518152 5.52E-06 0.000132171 PTS ENSG00000150787 1618.696905 0.692254571 5.53E-06 0.0001323 SELENOM ENSG00000198832 306.5863452 -0.95803707 5.72E-06 0.000136392 MFNG ENSG00000100060 6961.650476 -0.584801771 5.82E-06 0.000138532 ANKRD54 ENSG00000100124 1143.972609 -0.499339606 5.99E-06 0.00014199 ABCB9 ENSG00000150967 259.9568323 -1.2177692 6.00E-06 0.000142066 BNIP2 ENSG00000140299 11210.97582 0.724245127 6.00E-06 0.000142066 FAM198B ENSG00000164125 10738.67724 1.235135775 6.11E-06 0.000144042

CC2D1B ENSG00000154222 4697.719446 -0.389847513 6.15E-06 0.000144842 RAB29 ENSG00000117280 5965.808371 -0.796088611 6.17E-06 0.000145134 SLA ENSG00000155926 28205.55116 1.404501431 6.21E-06 0.000145895 TOP1 ENSG00000198900 8998.405065 0.722225073 6.22E-06 0.000146086 ZNF691 ENSG00000164011 356.3271179 -0.922692937 6.40E-06 0.00014968 FAM98C ENSG00000130244 1361.453754 -0.594870263 6.45E-06 0.000150403 CRIP2 ENSG00000182809 749.8886182 -1.219009707 6.44E-06 0.000150403 CYP19A1 ENSG00000137869 26.46565971 2.229986819 6.52E-06 0.000151614 LAPTM4A ENSG00000068697 9904.053031 0.537917072 6.58E-06 0.000152827 ABCA7 ENSG00000064687 12514.46127 -0.607753117 6.59E-06 0.000152965 LRCH1 ENSG00000136141 2906.23954 0.579607687 6.64E-06 0.000153614 EPB41L3 ENSG00000082397 5421.838567 0.976678863 6.64E-06 0.000153614 SDC4 ENSG00000124145 698.0600529 1.69406183 6.68E-06 0.000154487 GNLY ENSG00000115523 26406.30122 -1.36344906 6.76E-06 0.000155992 CRYZ ENSG00000116791 884.7275345 -0.719442149 6.78E-06 0.00015626 H1F0 ENSG00000189060 3998.283854 1.231486608 6.82E-06 0.000156846 XRN2 ENSG00000088930 14746.74735 0.494784764 6.97E-06 0.00015963 LACTB ENSG00000103642 3815.980188 0.855191686 7.01E-06 0.000159947 TPGS1 ENSG00000141933 686.5484568 -0.717754536 7.01E-06 0.000159947 ABCG1 ENSG00000160179 2256.933711 1.069135687 7.04E-06 0.000160335 DLEC1 ENSG00000008226 566.1177293 -0.71665815 7.05E-06 0.000160546 UNC119B ENSG00000175970 2247.172189 -0.510362326 7.08E-06 0.000160857 PLEKHB2 ENSG00000115762 5196.884342 0.768998198 7.08E-06 0.000160857 FKBP4 ENSG00000004478 2356.362624 -0.689686125 7.11E-06 0.000161371 ZNF425 ENSG00000204947 83.4743476 -1.125052359 7.22E-06 0.000163657 KCTD3 ENSG00000136636 678.8878297 0.937760664 7.29E-06 0.000165072 USP5 ENSG00000111667 4175.545086 -0.51713917 7.34E-06 0.000165532 HDAC7 ENSG00000061273 9058.855059 -0.555206662 7.33E-06 0.000165532 ARID5A ENSG00000196843 4752.684774 0.883594349 7.39E-06 0.000166347 SDCCAG3 ENSG00000165689 2528.757921 -0.581343091 7.39E-06 0.000166347 MRFAP1L1 ENSG00000178988 4132.299493 -0.785056462 7.46E-06 0.000167764 SERPINH1 ENSG00000149257 375.0623777 -0.776373702 7.50E-06 0.000168475 PELI1 ENSG00000197329 19699.58068 1.312260943 7.50E-06 0.000168475 ZMYM3 ENSG00000147130 2640.288424 -0.457351251 7.55E-06 0.000169145 ALPK1 ENSG00000073331 4691.513926 0.998786199 7.58E-06 0.000169648 TARBP2 ENSG00000139546 948.8532839 -0.577314589 7.63E-06 0.000170447 BAIAP2L1 ENSG00000006453 1226.414178 0.985473085 7.69E-06 0.000171737 LIMA1 ENSG00000050405 916.3051324 -0.843190061 7.73E-06 0.000172405 ASB14 ENSG00000239388 277.9711253 0.798241012 7.80E-06 0.00017368 GIN1 ENSG00000145723 395.2435895 -0.885055928 7.82E-06 0.000173785 ZNF501 ENSG00000186446 87.42145925 -1.0161587 7.86E-06 0.000174219 CHST12 ENSG00000136213 2831.059035 -0.972237663 7.99E-06 0.000176344 MMP8 ENSG00000118113 3331.225775 1.929087135 8.04E-06 0.000177209 SNAI3 ENSG00000185669 1054.426967 -0.780930644 8.08E-06 0.000177817 XCL2 ENSG00000143185 489.7486109 -1.247146622 8.10E-06 0.000178138 BCL2L12 ENSG00000126453 550.4053005 -0.738521218 8.12E-06 0.000178359

PPOX ENSG00000143224 1517.32468 -0.678394321 8.18E-06 0.000179613 EIF4G1 ENSG00000114867 15950.33842 0.368737107 8.32E-06 0.000182435 PCSK1N ENSG00000102109 53.07001987 -1.573141408 8.36E-06 0.000183166 OGFOD3 ENSG00000181396 1028.198632 -0.60050914 8.46E-06 0.000185148 TM9SF2 ENSG00000125304 19571.39789 0.569757899 8.47E-06 0.00018518 FBXO2 ENSG00000116661 211.4321332 -1.3402261 8.47E-06 0.00018518 ARFGEF2 ENSG00000124198 6545.72169 0.558861043 8.49E-06 0.00018551 FAM160B1 ENSG00000151553 3626.772305 0.891868467 8.60E-06 0.000186928 DYNC1LI2 ENSG00000135720 9005.827392 0.610926651 8.92E-06 0.00019343 CHD1 ENSG00000153922 13688.54271 0.885259302 8.94E-06 0.000193507 TMUB1 ENSG00000164897 2096.637226 -0.647296278 8.93E-06 0.000193507 COL6A2 ENSG00000142173 4133.372409 -1.258087722 9.01E-06 0.000194616 ANPEP ENSG00000166825 27856.57888 0.95136481 9.16E-06 0.000197657 ZBTB16 ENSG00000109906 3907.225955 1.726171952 9.32E-06 0.000200566 CCDC86 ENSG00000110104 980.2411319 -0.417845737 9.33E-06 0.000200608 TUBGCP3 ENSG00000126216 3891.058004 0.383640594 9.34E-06 0.000200687 KRBA1 ENSG00000133619 874.6802204 -0.551535454 9.39E-06 0.000201232 PDE4B ENSG00000184588 8410.115416 0.90004381 9.55E-06 0.000204008 ASAH1 ENSG00000104763 24709.39507 0.752092592 9.57E-06 0.000204335 FGD3 ENSG00000127084 22348.80822 -0.475234629 9.60E-06 0.000204673 HNRNPU ENSG00000153187 45588.31316 0.221845675 9.70E-06 0.000206055 BCL10 ENSG00000142867 2257.625774 0.699187195 9.73E-06 0.000206557 NAA25 ENSG00000111300 3371.775307 0.669878812 9.78E-06 0.000207254 CYP2U1 ENSG00000155016 587.0313531 -0.698402137 9.84E-06 0.000208401 ANKRD34A ENSG00000272031 152.3430997 -0.896144466 9.86E-06 0.000208719 SPET9 ENSG00000184640 41669.97407 -0.4597164 9.89E-06 0.000209193 FBXL5 ENSG00000118564 29012.96878 0.726013639 9.91E-06 0.000209233 AQR ENSG00000021776 5679.647805 0.441442997 9.93E-06 0.000209366 RP1-122P22.4 ENSG00000268628 19.68622173 1.711575346 9.94E-06 0.000209429 KHK ENSG00000138030 228.7771636 -1.006001235 9.95E-06 0.00020953 NUBP2 ENSG00000095906 1474.615812 -0.707461627 9.97E-06 0.000209721 COL5A3 ENSG00000080573 412.1764475 -1.625446334 9.99E-06 0.000209791 SYF2 ENSG00000117614 7602.343514 0.517949205 1.00E-05 0.000209791 MGAT2 ENSG00000168282 2024.661862 -0.801610888 1.00E-05 0.00021048 YPEL5 ENSG00000119801 22102.63075 0.73653822 1.01E-05 0.000211866 ZFR ENSG00000056097 8230.742123 0.51862033 1.01E-05 0.000211866 SPIRE2 ENSG00000204991 401.3435938 -1.09937658 1.02E-05 0.000212718 AMIGO1 ENSG00000181754 885.1298878 -0.907298527 1.03E-05 0.000214768 C3orf18 ENSG00000088543 588.1586767 -0.870815026 1.04E-05 0.000215682 TUBB4A ENSG00000104833 98.26509622 -1.595357867 1.05E-05 0.000217361 ARMC8 ENSG00000114098 4587.832999 0.422065905 1.06E-05 0.000218655 ZMIZ1 ENSG00000108175 14654.67924 0.731973567 1.07E-05 0.000219273 ARID4A ENSG00000032219 5135.662189 0.720249973 1.08E-05 0.000222157 UBE2E2 ENSG00000182247 1276.259897 0.863262014 1.08E-05 0.000222157 GALNT5 ENSG00000136542 21.85226591 1.915252284 1.10E-05 0.000223878 TRMT6 ENSG00000089195 2721.571706 0.803858657 1.11E-05 0.000224967

NAALADL1 ENSG00000168060 525.122284 -0.668735876 1.11E-05 0.000224967 RNF175 ENSG00000145428 952.3750584 1.064643202 1.11E-05 0.000224967 FAM76B ENSG00000077458 4948.890914 0.548189237 1.11E-05 0.000225138 RAB11FIP3 ENSG00000090565 2961.251945 -0.71871426 1.11E-05 0.000225268 SLC12A6 ENSG00000140199 14502.26516 0.684899647 1.13E-05 0.000229133 SLC51A ENSG00000163959 272.9898235 0.840159763 1.14E-05 0.000229453 MATK ENSG00000007264 4593.127809 -1.14503443 1.15E-05 0.000230742 ALAS1 ENSG00000023330 3454.751675 0.701838418 1.15E-05 0.000231161 MUTYH ENSG00000132781 1142.156186 -0.568334593 1.15E-05 0.00023193 NTHL1 ENSG00000065057 404.6668481 -0.820541873 1.16E-05 0.000233092 CAD ENSG00000084774 2742.813051 -0.621227015 1.17E-05 0.000235473 RNF152 ENSG00000176641 60.60292158 1.773942432 1.18E-05 0.000235662 TANK ENSG00000136560 4485.989242 0.756598815 1.18E-05 0.000235843 CISH ENSG00000114737 1230.130173 -1.208577622 1.19E-05 0.000237192 DHX57 ENSG00000163214 2941.313035 0.522110744 1.19E-05 0.000237939 SSFA2 ENSG00000138434 6879.800735 0.678317379 1.20E-05 0.000238049 DNAH17 ENSG00000187775 3170.914602 0.957559067 1.20E-05 0.000238049 TMEM204 ENSG00000131634 1029.813653 -1.148872177 1.20E-05 0.000238192 LCMT2 ENSG00000168806 255.6698167 -1.218350585 1.21E-05 0.000239378 DRAM1 ENSG00000136048 1095.066148 1.169907134 1.21E-05 0.000239502 HADHB ENSG00000138029 11422.59429 0.559048496 1.22E-05 0.000241 RPA2 ENSG00000117748 3718.863006 -0.520107694 1.25E-05 0.000246471 AZIN1 ENSG00000155096 7711.638333 0.723300927 1.25E-05 0.000246471 ANKRD13D ENSG00000172932 12921.99372 -0.543798697 1.26E-05 0.000247452 ADAM10 ENSG00000137845 14869.63375 0.635229812 1.26E-05 0.000247452 RP11-463J10.2 ENSG00000258928 794.1647801 1.354893261 1.26E-05 0.000247452 UMPS ENSG00000114491 841.9033817 -0.769765309 1.26E-05 0.000248594 HSPBP1 ENSG00000133265 764.8628677 -0.670148612 1.27E-05 0.000249495 TRIM46 ENSG00000163462 587.6840897 -0.868240553 1.27E-05 0.00024996 RHOT2 ENSG00000140983 7754.231967 -0.623889629 1.31E-05 0.000255105 ZNF24 ENSG00000172466 5510.615989 1.440175284 1.31E-05 0.000255105 ATP2A2 ENSG00000174437 9366.649404 0.731873437 1.32E-05 0.000258227 MORF4L1 ENSG00000185787 15486.22718 0.389596894 1.34E-05 0.000260334 SPRY2 ENSG00000136158 295.7087146 1.52247529 1.34E-05 0.000260472 IFNGR2 ENSG00000159128 13594.0561 0.702419369 1.34E-05 0.000260949 FBXW9 ENSG00000132004 208.304249 -0.814804403 1.34E-05 0.00026114 EMC9 ENSG00000100908 412.0723523 -0.785488809 1.35E-05 0.000261578 TJAP1 ENSG00000137221 3933.532283 -0.478031074 1.35E-05 0.000261765 RNASE3 ENSG00000169397 1022.088785 2.046139194 1.35E-05 0.000261765 UQCC2 ENSG00000137288 1556.439863 -0.565809287 1.35E-05 0.000261984 CD1C ENSG00000158481 1125.541865 -0.957318903 1.36E-05 0.000262334 SAMD1 ENSG00000141858 2065.771061 -0.712154155 1.38E-05 0.000266036 GUCY2C ENSG00000070019 741.771154 1.113100168 1.39E-05 0.000268269 ATP2B1 ENSG00000070961 12803.14316 0.904503554 1.39E-05 0.000268269 SNX3 ENSG00000112335 9074.521185 0.581723954 1.39E-05 0.000268308 DALRD3 ENSG00000178149 1327.254689 -0.491752784 1.41E-05 0.000270996

CREB5 ENSG00000146592 5768.644701 1.655860457 1.41E-05 0.000271962 ENC1 ENSG00000171617 4486.029605 1.136568052 1.42E-05 0.000273594 GZMM ENSG00000197540 3392.915331 -1.352803153 1.43E-05 0.000274429 FRS2 ENSG00000166225 2193.437267 1.022682002 1.45E-05 0.000277791 SEMA6C ENSG00000143434 251.9563197 -0.84250934 1.46E-05 0.000278882 FAHD2B ENSG00000144199 388.5828085 -0.849026718 1.47E-05 0.000280739 ENPP5 ENSG00000112796 315.6970755 -1.255811494 1.47E-05 0.000280756 BMT2 ENSG00000164603 2120.533843 0.569006888 1.49E-05 0.000283698 NCR3 ENSG00000204475 1002.549264 -1.038207312 1.50E-05 0.000285563 BCS1L ENSG00000074582 973.642706 -0.679611181 1.50E-05 0.00028592 PKD1 ENSG00000008710 4989.021103 -0.68142585 1.51E-05 0.000286165 IL17RE ENSG00000163701 85.23842875 -1.228762013 1.51E-05 0.000286477 NOTCH3 ENSG00000074181 206.098098 1.524356036 1.52E-05 0.000288121 DCXR ENSG00000169738 989.2335688 -0.631412121 1.53E-05 0.000288191 CYB5R2 ENSG00000166394 128.7189787 1.28165534 1.53E-05 0.000288641 CMTM6 ENSG00000091317 20013.90532 0.666300379 1.54E-05 0.000290945 APC2 ENSG00000115266 357.2016524 -1.261779814 1.55E-05 0.00029193 SUMO3 ENSG00000184900 7607.299813 0.509033245 1.56E-05 0.000293383 TET3 ENSG00000187605 11157.25094 0.879461686 1.57E-05 0.000294612 RPUSD3 ENSG00000156990 1876.9538 -0.524190328 1.58E-05 0.00029683 CHMP6 ENSG00000176108 1632.83032 -0.580948485 1.59E-05 0.000297446 SRSF10 ENSG00000188529 6163.919295 0.772357028 1.59E-05 0.000298887 HYLS1 ENSG00000198331 251.1862442 -0.920964245 1.60E-05 0.000299407 EOMES ENSG00000163508 1920.270972 -1.358210087 1.61E-05 0.000300929 MTMR3 ENSG00000100330 11629.91071 0.734608837 1.61E-05 0.000300995 BCL6 ENSG00000113916 18942.75782 1.225549031 1.62E-05 0.000301549 KIAA1033 ENSG00000136051 12927.4502 0.675224994 1.63E-05 0.00030294 SCRN2 ENSG00000141295 1336.153066 -0.58625311 1.64E-05 0.000304084 MMGT1 ENSG00000169446 3984.220458 0.415160076 1.64E-05 0.000304084 LONRF3 ENSG00000175556 1483.175875 1.475150818 1.64E-05 0.000304084 KCTD11 ENSG00000213859 642.2361855 -1.04974201 1.65E-05 0.000306657 IL12RB1 ENSG00000096996 3362.091795 -0.641455686 1.68E-05 0.000310716 GNAQ ENSG00000156052 13474.0785 0.915526854 1.69E-05 0.000313513 MCTP1 ENSG00000175471 4654.350511 0.726743091 1.71E-05 0.000316495 ZC3H15 ENSG00000065548 7554.41366 0.580227957 1.72E-05 0.000317334 SAFB2 ENSG00000130254 8506.026305 -0.282568204 1.72E-05 0.000318251 ZNF181 ENSG00000197841 630.04221 -0.756994916 1.73E-05 0.000318742 TMEM131 ENSG00000075568 8752.790642 0.568065875 1.74E-05 0.000319776 MYO10 ENSG00000145555 218.8198107 1.085562425 1.74E-05 0.000320082 SCAF11 ENSG00000139218 5141.570027 0.617827745 1.76E-05 0.00032337 TPP1 ENSG00000166340 36702.254 0.644463365 1.76E-05 0.000323847 WDR46 ENSG00000227057 2969.568152 -0.475927368 1.78E-05 0.000326344 VPS8 ENSG00000156931 5461.938602 0.489787908 1.80E-05 0.000329074 SPATA6 ENSG00000132122 1026.392003 0.985831579 1.81E-05 0.00033146 PCOLCE ENSG00000106333 426.1559005 -0.64167111 1.85E-05 0.000337793 GPRIN1 ENSG00000169258 136.6139803 -0.818007037 1.86E-05 0.000338068

DOCK5 ENSG00000147459 6888.608826 0.926513703 1.87E-05 0.0003404 ARG1 ENSG00000118520 1577.151968 1.835415909 1.88E-05 0.000341176 STAG1 ENSG00000118007 4252.037314 0.540717995 1.90E-05 0.000344486 PDE4D ENSG00000113448 9291.984225 1.229574065 1.90E-05 0.000344509 MIS18A ENSG00000159055 343.2774535 -0.616196507 1.91E-05 0.000344603 JADE2 ENSG00000043143 6611.45937 -0.943914111 1.93E-05 0.000348151 B4GAT1 ENSG00000174684 222.4826287 -0.846131788 1.93E-05 0.000348151 LIPE ENSG00000079435 297.3984548 -0.822319832 1.94E-05 0.000348742 EFNB1 ENSG00000090776 661.1277894 -0.738265738 1.94E-05 0.000348748 CTSF ENSG00000174080 873.7391611 -0.97659375 1.95E-05 0.000349971 FZD5 ENSG00000163251 136.7399461 1.142725033 1.95E-05 0.000350611 HMGB3 ENSG00000029993 831.5254561 0.991127638 1.95E-05 0.000350611 PHF20L1 ENSG00000129292 7748.519952 0.525477757 1.97E-05 0.000354056 YBX3 ENSG00000060138 6589.56706 0.747376952 1.98E-05 0.000354288 PCDH1 ENSG00000156453 199.12055 -1.664129038 1.98E-05 0.000355461 TRIM68 ENSG00000167333 812.8505052 -0.798718941 2.00E-05 0.000357473 CORO6 ENSG00000167549 221.1634507 -0.979804093 2.00E-05 0.000357782 RBM38 ENSG00000132819 8117.577651 1.010918258 2.00E-05 0.000357782 TMEM8B ENSG00000137103 610.3846965 -0.600302729 2.03E-05 0.000361435 NME9 ENSG00000181322 139.7759995 0.791186233 2.05E-05 0.000363419 LRRK2 ENSG00000188906 18098.92373 0.863745799 2.07E-05 0.000367122 ATP13A2 ENSG00000159363 3400.362843 -0.47912996 2.09E-05 0.000369878 ANO10 ENSG00000160746 1483.492137 0.706994384 2.10E-05 0.000370603 TAF5L ENSG00000135801 2809.087544 0.440363927 2.10E-05 0.000370939 SMAP1 ENSG00000112305 3597.750337 0.347075138 2.11E-05 0.000372231 ASPSCR1 ENSG00000169696 2069.665615 -0.618104103 2.12E-05 0.000373889 CDK19 ENSG00000155111 4840.11188 0.65156267 2.13E-05 0.000375327 TPST1 ENSG00000169902 1280.192955 1.661583312 2.14E-05 0.000376873 PXK ENSG00000168297 6019.91714 0.803330532 2.16E-05 0.00037961 XCR1 ENSG00000173578 70.12679429 -1.551299161 2.21E-05 0.000385827 EIF3M ENSG00000149100 10737.13617 0.296428648 2.22E-05 0.000387998 TMEM183A ENSG00000163444 6159.934412 0.356344017 2.25E-05 0.000393244 OSGEPL1 ENSG00000128694 565.6897762 -0.700850474 2.26E-05 0.00039382 CLINT1 ENSG00000113282 8450.926433 0.413259666 2.26E-05 0.000394698 TACC1 ENSG00000147526 8020.420521 1.168322344 2.28E-05 0.000397147 DHCR24 ENSG00000116133 666.9747149 -1.192994079 2.28E-05 0.000397559 HIPK1 ENSG00000163349 6008.079044 0.84369849 2.30E-05 0.000399405 TBX21 ENSG00000073861 6622.062401 -1.271930357 2.30E-05 0.000399608 SMAP2 ENSG00000084070 61584.50029 0.805929049 2.30E-05 0.000399756 CCDC61 ENSG00000104983 904.7269896 -0.82688693 2.31E-05 0.000399818 PIK3R1 ENSG00000145675 18902.97219 1.117992158 2.32E-05 0.000401333 GTF3C5 ENSG00000148308 3411.918879 -0.359004672 2.32E-05 0.000401907 TFEC ENSG00000105967 5737.669767 0.941208759 2.33E-05 0.000403499 RGL1 ENSG00000143344 740.8434169 1.239573813 2.34E-05 0.000403713 PRMT3 ENSG00000185238 1657.922042 0.496839012 2.35E-05 0.000405426 JAG1 ENSG00000101384 668.6096123 1.018422063 2.36E-05 0.000407293

PAPD4 ENSG00000164329 9267.392783 0.46584224 2.37E-05 0.000408483 ZFAND3 ENSG00000156639 8229.709922 0.53975062 2.41E-05 0.000412709 CCDC38 ENSG00000165972 12.29492124 1.739653294 2.42E-05 0.000414525 TNPO3 ENSG00000064419 6338.930661 0.396166414 2.43E-05 0.00041583 SLX4 ENSG00000188827 1886.650849 -0.405248233 2.44E-05 0.00041756 TWISTNB ENSG00000105849 1322.68394 0.738599253 2.47E-05 0.000420889 SLC36A4 ENSG00000180773 3037.612704 0.844202708 2.49E-05 0.000423911 OSER1 ENSG00000132823 8639.191187 0.70149387 2.49E-05 0.000424906 AZIN2 ENSG00000142920 228.8842958 -1.117043893 2.50E-05 0.000426155 ELP6 ENSG00000163832 1172.105888 -0.455135208 2.51E-05 0.000426367 AMFR ENSG00000159461 4592.490506 0.402805715 2.52E-05 0.000428112 RBCK1 ENSG00000125826 9087.143508 -0.493574738 2.52E-05 0.000428112 METTL13 ENSG00000010165 1242.538991 -0.815589056 2.53E-05 0.000428364 GDPD1 ENSG00000153982 164.7861183 -0.80090783 2.55E-05 0.000432286 SOWAHD ENSG00000187808 254.8549519 -1.096833426 2.56E-05 0.000433439 PPM1B ENSG00000138032 6539.741927 0.694326708 2.58E-05 0.000435538 MIGA2 ENSG00000148343 3450.755718 -0.503676387 2.60E-05 0.000438886 SNAPC4 ENSG00000165684 2415.79005 -0.458646235 2.62E-05 0.000440746 MICU1 ENSG00000107745 5239.869953 0.587549784 2.62E-05 0.000441184 GCSAM ENSG00000174500 687.3545986 -1.129559473 2.63E-05 0.000442583 C1orf56 ENSG00000143443 210.7226775 -0.699913742 2.65E-05 0.000442882 PPM1A ENSG00000100614 7976.387262 0.609146048 2.64E-05 0.000442882 ZNF470 ENSG00000197016 235.5048502 -0.935036333 2.64E-05 0.000442882 PROSER1 ENSG00000120685 5589.709079 0.575318223 2.65E-05 0.000442882 SERINC1 ENSG00000111897 16087.11808 0.60435941 2.65E-05 0.000442894 NELFB ENSG00000188986 4100.519469 -0.536778008 2.67E-05 0.00044506 PSPN ENSG00000125650 145.1788178 -0.876695247 2.68E-05 0.000446599 ADAMTS1 ENSG00000154734 184.7120258 -1.654805124 2.69E-05 0.000448194 SOWAHC ENSG00000198142 393.5344472 1.047107147 2.71E-05 0.000450819 CNOT4 ENSG00000080802 2042.257529 0.482913832 2.72E-05 0.000451338 C21orf140 ENSG00000222018 35.11389455 -0.967259201 2.72E-05 0.000452007 AIM1 ENSG00000112297 12889.65416 0.755195799 2.76E-05 0.000457195 CNEP1R1 ENSG00000205423 2014.81807 0.928544044 2.76E-05 0.000457401 RBPJ ENSG00000168214 9739.52747 1.044366282 2.77E-05 0.000458174 ZNF823 ENSG00000197933 195.6595356 -0.962867457 2.77E-05 0.000458539 TRDMT1 ENSG00000107614 941.5639006 0.553717051 2.82E-05 0.000466152 NEMF ENSG00000165525 6868.716051 0.438707443 2.82E-05 0.000466334 CROCC2 ENSG00000226321 68.35454818 -1.690882174 2.83E-05 0.000466996 CC2D1A ENSG00000132024 3273.874679 -0.368097944 2.84E-05 0.000467499 SH3D19 ENSG00000109686 78.43381424 1.126502666 2.84E-05 0.000467499 TONSL ENSG00000160949 654.5642437 -0.833018076 2.85E-05 0.000468082 RPS6KA3 ENSG00000177189 7805.012494 0.86304986 2.85E-05 0.000468646 REV3L ENSG00000009413 3692.949004 0.512198344 2.86E-05 0.000470124 MRPL34 ENSG00000130312 1812.429883 -0.523766151 2.88E-05 0.000471986 FAM53A ENSG00000174137 61.08786033 -1.069188909 2.90E-05 0.000474674 ZNF703 ENSG00000183779 1139.984258 -1.129260656 2.91E-05 0.000475676

PCNX1 ENSG00000100731 15629.49348 0.676521879 2.93E-05 0.000479951 PPT1 ENSG00000131238 29514.559 0.810510152 2.94E-05 0.000481398 RAB12 ENSG00000206418 6497.535106 0.640238792 2.95E-05 0.000481951 ANKRD22 ENSG00000152766 447.2927744 1.384734016 2.96E-05 0.000483606 AP3S1 ENSG00000177879 4750.929678 0.589609208 2.99E-05 0.000487073 AP000322.53 ENSG00000243627 18.9218884 1.428570913 2.99E-05 0.000487668 LARP4B ENSG00000107929 8610.50737 0.466988942 3.00E-05 0.000488154 SLC25A32 ENSG00000164933 2141.593717 0.5193675 3.00E-05 0.000488742 OGFOD1 ENSG00000087263 1551.390563 -0.586836237 3.04E-05 0.000493652 DAPK1 ENSG00000196730 11105.66169 0.849598587 3.04E-05 0.000493819 SCFD1 ENSG00000092108 5955.950481 0.584598414 3.07E-05 0.000496528 TBC1D13 ENSG00000107021 2743.449671 -0.36563813 3.09E-05 0.000500605 LPCAT3 ENSG00000111684 3295.901118 0.478250051 3.11E-05 0.000501844 C16orf58 ENSG00000140688 4744.981685 -0.449507909 3.13E-05 0.000504993 PRKCB ENSG00000166501 17885.89943 0.490544597 3.14E-05 0.00050654 POLR2H ENSG00000163882 1241.527826 -0.630121306 3.17E-05 0.000510424 KLF9 ENSG00000119138 13154.90484 1.226685822 3.18E-05 0.000511464 PSD4 ENSG00000125637 17259.13865 -0.525861587 3.26E-05 0.000522249 PP7080 ENSG00000188242 1252.498525 -0.577643665 3.27E-05 0.000523887 SLCO2B1 ENSG00000137491 54.25899361 1.747094798 3.31E-05 0.000529168 CYP4F22 ENSG00000171954 166.9781162 -1.461742163 3.34E-05 0.000532509 MSH3 ENSG00000113318 1368.357579 0.586057837 3.35E-05 0.000533054 ALDH1B1 ENSG00000137124 287.9482572 -0.853996636 3.38E-05 0.000538018 SEMA4F ENSG00000135622 672.0629729 -0.691338127 3.39E-05 0.000538502 PGBD2 ENSG00000185220 519.6160803 -1.034646922 3.39E-05 0.000539019 PLEKHG4 ENSG00000196155 879.0913097 -0.769648217 3.40E-05 0.000539529 CUTA ENSG00000112514 2353.413518 -0.565566204 3.41E-05 0.000541679 LYRM7 ENSG00000186687 687.8136562 -1.233440777 3.44E-05 0.000543689 TMEM81 ENSG00000174529 168.1467843 -0.835483964 3.44E-05 0.000543937 NECAB3 ENSG00000125967 482.752317 -0.656827891 3.50E-05 0.000550967 TRIM33 ENSG00000197323 7193.803924 0.742400161 3.50E-05 0.000550967 SMC5 ENSG00000198887 4996.724278 0.655442527 3.52E-05 0.000553866 THEM5 ENSG00000196407 739.7246699 -0.826011756 3.54E-05 0.00055565 DBF4 ENSG00000006634 974.9239449 0.726680174 3.55E-05 0.000556734 AC013461.1 ENSG00000091436 2826.027057 0.78224122 3.57E-05 0.000559145 LMTK2 ENSG00000164715 5911.036874 0.806913822 3.64E-05 0.000568275 CPSF1 ENSG00000071894 8806.351315 -0.680592914 3.67E-05 0.0005737 SCAPER ENSG00000140386 1780.655768 0.546670924 3.74E-05 0.0005819 VARS ENSG00000204394 3852.138171 -0.47355161 3.74E-05 0.000582125 GGPS1 ENSG00000152904 1968.231458 -0.558276982 3.77E-05 0.000585288 FAM193B ENSG00000146067 8538.279122 -0.48949396 3.79E-05 0.000588176 THAP7 ENSG00000184436 1023.112358 -0.731014381 3.80E-05 0.000588662 SARAF ENSG00000133872 34194.85504 0.40606708 3.81E-05 0.000589399 PRRT4 ENSG00000224940 284.8052496 1.709651798 3.82E-05 0.000590412 CCDC65 ENSG00000139537 613.962009 -1.039185035 3.82E-05 0.000590412 DOPEY2 ENSG00000142197 4320.92597 0.502844293 3.82E-05 0.000590732

BLOC1S4 ENSG00000186222 902.747143 -0.730018797 3.83E-05 0.000591563 FAM204A ENSG00000165669 3895.775999 0.331436606 3.84E-05 0.000592683 MBD2 ENSG00000134046 13323.23281 0.491642924 3.86E-05 0.000594782 ACOX2 ENSG00000168306 83.95393229 1.369562722 3.87E-05 0.000595672 DICER1 ENSG00000100697 9564.195091 0.871714494 3.89E-05 0.000598525 C7orf43 ENSG00000146826 3721.821916 -0.519297888 3.90E-05 0.000599706 PCYT2 ENSG00000185813 1365.418204 -0.582545961 3.90E-05 0.000600012 HMOX1 ENSG00000100292 12395.1461 0.906964087 3.90E-05 0.000600012 UBXN4 ENSG00000144224 16148.1717 0.477728847 3.91E-05 0.000600224 SNTA1 ENSG00000101400 346.4651504 -1.030213027 3.92E-05 0.000601897 VPS26A ENSG00000122958 3624.562059 1.071268338 3.94E-05 0.000603065 TMEM175 ENSG00000127419 3357.878778 -0.609007884 3.94E-05 0.000603065 SBK1 ENSG00000188322 2574.247637 -1.134415188 3.96E-05 0.000604064 PYCRL ENSG00000104524 178.8268139 -1.04104503 3.95E-05 0.000604064 CCDC167 ENSG00000198937 753.9032951 -0.906448059 3.97E-05 0.000606008 THUMPD2 ENSG00000138050 1539.262698 0.660597401 4.01E-05 0.000610826 CUL2 ENSG00000108094 3387.753623 0.496701359 4.07E-05 0.000619777 LGALS3 ENSG00000131981 10960.46767 0.72368988 4.11E-05 0.000624904 TAB1 ENSG00000100324 3398.598372 -0.421063748 4.14E-05 0.000626856 TRAF2 ENSG00000127191 1312.244821 -0.64847638 4.14E-05 0.000626856 HSPA12B ENSG00000132622 245.4462529 1.157147476 4.15E-05 0.000628276 FMN1 ENSG00000248905 1826.356452 1.300493549 4.18E-05 0.000630768 FBXO38 ENSG00000145868 4754.687644 0.431814369 4.19E-05 0.000631875 GTPBP6 ENSG00000178605 4057.300773 -0.495750888 4.24E-05 0.00063806 GADD45B ENSG00000099860 5478.959756 0.915197875 4.26E-05 0.000639327 WAC ENSG00000095787 20244.06267 0.469031629 4.26E-05 0.000639747 SNIP1 ENSG00000163877 2815.442926 0.700248213 4.27E-05 0.000640092 SLC43A1 ENSG00000149150 707.8815181 -0.573327789 4.33E-05 0.00064849 TMF1 ENSG00000144747 5966.9731 0.626619322 4.34E-05 0.000648973 CCL5 ENSG00000271503 23526.06033 -1.139930375 4.37E-05 0.000653002 NAF1 ENSG00000145414 887.4875848 0.525941363 4.44E-05 0.000661056 KIF13A ENSG00000137177 4623.257381 0.76586957 4.44E-05 0.000661056 COL5A1 ENSG00000130635 47.03061977 -1.627374454 4.46E-05 0.000664561 PLEKHF2 ENSG00000175895 5055.980245 0.434020938 4.49E-05 0.000668031 UFD1L ENSG00000070010 6708.135904 0.488577712 4.51E-05 0.000670048 DNMBP ENSG00000107554 2263.677251 0.73040258 4.51E-05 0.000670071 SKAP2 ENSG00000005020 9749.932684 0.737360045 4.52E-05 0.000670421 FAM212A ENSG00000185614 67.57817581 -1.322639515 4.61E-05 0.000682356 SLAMF6 ENSG00000162739 8199.016493 -0.928152615 4.64E-05 0.00068772 GAPVD1 ENSG00000165219 2896.991396 0.580654976 4.66E-05 0.000690029 LTK ENSG00000062524 1122.100119 -1.268132853 4.69E-05 0.000693283 MASTL ENSG00000120539 1133.917794 0.78394672 4.72E-05 0.00069669 MKS1 ENSG00000011143 516.7018455 -0.73704749 4.76E-05 0.000701021 ARHGAP30 ENSG00000186517 44561.41731 -0.374346653 4.77E-05 0.000702006 RNF187 ENSG00000168159 4294.725927 -0.407812097 4.79E-05 0.000703135 NEDD4L ENSG00000049759 543.1469037 0.734379364 4.81E-05 0.000705986

TAPT1 ENSG00000169762 2715.991724 0.40393184 4.83E-05 0.000707875 RPF1 ENSG00000117133 5194.508379 0.360823306 4.83E-05 0.000707875 ITGA3 ENSG00000005884 332.6099289 -0.940691818 4.83E-05 0.000707875 SYNE3 ENSG00000176438 11427.42462 0.675647692 4.85E-05 0.000710787 LMBRD1 ENSG00000168216 5794.659692 0.543187406 4.87E-05 0.00071271 C12orf65 ENSG00000130921 654.8569976 -0.617174772 4.88E-05 0.000713235 HGSNAT ENSG00000165102 6155.099641 0.742114177 4.88E-05 0.000713235 MAST3 ENSG00000099308 9934.141272 -0.516259058 5.03E-05 0.000732407 EIF4G3 ENSG00000075151 9048.929444 0.464567634 5.07E-05 0.000737095 SLC44A1 ENSG00000070214 4563.144162 0.719980892 5.08E-05 0.000737225 HSD17B8 ENSG00000204228 388.6045352 -0.915248184 5.10E-05 0.00074065 KANK3 ENSG00000186994 99.54173023 -1.443039275 5.12E-05 0.000742124 UBR1 ENSG00000159459 4262.281608 0.486904637 5.13E-05 0.000744174 MRPL44 ENSG00000135900 2742.741261 0.462555967 5.14E-05 0.00074429 AGPS ENSG00000018510 4437.003751 0.668067466 5.16E-05 0.000746847 CAPRIN1 ENSG00000135387 13696.61874 0.387905995 5.17E-05 0.000747755 NHSL1 ENSG00000135540 305.8724112 0.892499169 5.21E-05 0.000752205 ETV3 ENSG00000117036 4077.325522 0.725094752 5.23E-05 0.000754234 MAP4K1 ENSG00000104814 9688.757202 -0.567802316 5.24E-05 0.000754234 PNN ENSG00000100941 11682.75368 0.553356862 5.24E-05 0.000754327 C5AR1 ENSG00000197405 23578.6583 1.040999456 5.26E-05 0.000756822 UBAP1 ENSG00000165006 6741.029458 0.663132392 5.27E-05 0.000757465 P2RX4 ENSG00000135124 3930.673729 0.568571485 5.29E-05 0.000759449 ORAOV1 ENSG00000149716 2106.924558 -0.499816174 5.31E-05 0.00076016 KIAA0825 ENSG00000185261 229.207966 1.003136652 5.31E-05 0.000760364 PLPP3 ENSG00000162407 87.14422981 1.117427438 5.34E-05 0.000762683 TWNK ENSG00000107815 496.5993621 -0.825747428 5.35E-05 0.000763909 RPUSD1 ENSG00000007376 1282.972603 -0.716276392 5.40E-05 0.000769855 RP2 ENSG00000102218 4091.168925 0.761347055 5.43E-05 0.000773068 DNAJC3 ENSG00000102580 7082.637622 0.711952688 5.43E-05 0.000773068 SH3PXD2B ENSG00000174705 515.8943334 1.871685087 5.45E-05 0.000775089 ATXN7L2 ENSG00000162650 843.8279914 -0.482433265 5.49E-05 0.000780308 KLRB1 ENSG00000111796 6406.500901 -1.050051311 5.51E-05 0.000782026 STRAP ENSG00000023734 6142.444093 0.514330522 5.51E-05 0.000782134 TBL3 ENSG00000183751 2013.698611 -0.523493007 5.55E-05 0.000786407 WNT10A ENSG00000135925 122.6583663 -1.237104213 5.57E-05 0.000788811 NLRX1 ENSG00000160703 1335.870956 -0.593730032 5.57E-05 0.000789031 FLYWCH2 ENSG00000162076 750.1030235 -0.578008749 5.60E-05 0.000791511 IMPDH2 ENSG00000178035 4874.303194 -0.345674255 5.62E-05 0.000793668 CAMK2N1 ENSG00000162545 160.8651188 -1.216730012 5.64E-05 0.000795648 ADAMTS2 ENSG00000087116 1697.710924 2.042773632 5.64E-05 0.000795892 IKZF3 ENSG00000161405 10505.4009 -0.978944862 5.69E-05 0.00080105 MRPL4 ENSG00000105364 1942.316739 -0.502501824 5.70E-05 0.000801691 SYK ENSG00000165025 20970.35339 0.721208278 5.71E-05 0.000802988 RAB34 ENSG00000109113 1527.031983 0.619733065 5.73E-05 0.000805313 NUFIP2 ENSG00000108256 14185.14234 0.7520354 5.74E-05 0.000806202

AFAP1L2 ENSG00000169129 188.6784301 -0.965726412 5.86E-05 0.000820438 UBAP1L ENSG00000246922 1570.84918 -0.569256823 5.87E-05 0.000821429 FAM20C ENSG00000177706 1688.286869 0.950505378 5.88E-05 0.000822474 DPYD ENSG00000188641 12720.71424 0.718556271 5.89E-05 0.000822891 THAP3 ENSG00000041988 675.3508221 -0.724572719 5.96E-05 0.00083173 YME1L1 ENSG00000136758 11971.9057 0.371909728 5.97E-05 0.00083173 PI16 ENSG00000164530 275.4717463 -1.407030167 6.05E-05 0.000841696 TNKS2 ENSG00000107854 10351.38817 0.473695346 6.05E-05 0.000841816 ZC3H4 ENSG00000130749 4275.599033 -0.363027793 6.08E-05 0.000844021 SFPQ ENSG00000116560 23821.05229 0.557591877 6.10E-05 0.00084612 ZFP3 ENSG00000180787 1015.864017 -0.608720096 6.10E-05 0.00084612 LTB ENSG00000227507 8410.277784 -1.07063709 6.16E-05 0.000851995 CHRNA7 ENSG00000175344 152.4676531 1.216907489 6.17E-05 0.000853505 DEFA4 ENSG00000164821 1612.013882 1.820947936 6.18E-05 0.000853674 ALDOC ENSG00000109107 1043.482979 -0.619646618 6.23E-05 0.000859083 MRPS12 ENSG00000128626 1082.55583 -0.643761894 6.35E-05 0.000874179 NUP153 ENSG00000124789 6609.519204 0.59102218 6.37E-05 0.000876763 DEGS2 ENSG00000168350 31.35740985 -1.45967397 6.41E-05 0.000881366 ACAP1 ENSG00000072818 20911.97924 -0.577721118 6.42E-05 0.000881672 C4orf19 ENSG00000154274 123.8884671 1.499815812 6.59E-05 0.00090228 DOCK1 ENSG00000150760 195.5810141 1.099384704 6.60E-05 0.00090331 ZNF106 ENSG00000103994 13507.11738 0.562167318 6.64E-05 0.000908334 ABHD6 ENSG00000163686 353.5069763 -0.751763483 6.70E-05 0.000914378 MSRB2 ENSG00000148450 1307.791639 0.698932712 6.70E-05 0.000914378 ZNF563 ENSG00000188868 97.33130178 -1.04784066 6.71E-05 0.000916224 ZNF473 ENSG00000142528 834.0800604 -0.539428536 6.72E-05 0.000916851 UNK ENSG00000132478 2999.788956 -0.496375374 6.75E-05 0.000919051 SLC23A1 ENSG00000170482 604.9191005 0.629837692 6.79E-05 0.000925194 JOSD2 ENSG00000161677 1048.29172 -0.695422407 6.88E-05 0.000936716 ABCC10 ENSG00000124574 2903.637144 -0.485330507 6.93E-05 0.000941438 AC129492.6 ENSG00000214999 62.15875875 -1.403137922 6.93E-05 0.000941915 SMKR1 ENSG00000240204 78.86316679 -1.302276401 6.94E-05 0.00094245 HDHD3 ENSG00000119431 690.0263483 -0.863843726 6.95E-05 0.000943237 ANKRD27 ENSG00000105186 2008.114975 0.57991476 6.95E-05 0.000943237 POP7 ENSG00000172336 755.5732457 -0.609886957 6.99E-05 0.000947564 CARMIL2 ENSG00000159753 5104.140831 -0.827567193 7.06E-05 0.000955371 ANKRD34B ENSG00000189127 422.283329 1.365606302 7.07E-05 0.000957531 MTO1 ENSG00000135297 1910.90072 -0.515234065 7.11E-05 0.000961021 DHX40 ENSG00000108406 3705.019649 0.548832452 7.12E-05 0.000961231 C15orf61 ENSG00000189227 288.5658861 -0.804182678 7.20E-05 0.000971249 SLC31A1 ENSG00000136868 3957.893258 0.789764923 7.24E-05 0.000974695 SLC1A7 ENSG00000162383 464.2708308 -1.571919213 7.31E-05 0.000981847 AKIRIN2 ENSG00000135334 6581.501427 0.473715339 7.33E-05 0.000983486 CTD-2162K18.4 ENSG00000267260 11.43676263 -1.862977191 7.40E-05 0.000991732 RNF5 ENSG00000204308 1873.914764 -0.553760009 7.45E-05 0.000998129 SPRY3 ENSG00000168939 478.0588229 0.736360795 7.49E-05 0.001003856

STK17B ENSG00000081320 29095.22708 0.909729731 7.52E-05 0.001006629 MEN1 ENSG00000133895 2533.759973 -0.576926841 7.57E-05 0.001011132 CYB561A3 ENSG00000162144 4104.222873 -0.59576103 7.60E-05 0.001013781 ACER3 ENSG00000078124 2571.774226 1.364242424 7.60E-05 0.001013781 ARID2 ENSG00000189079 3414.247626 0.687697094 7.68E-05 0.001023126 C9orf69 ENSG00000238227 1321.565234 -1.183735411 7.75E-05 0.001032383 LRRC7 ENSG00000033122 133.0710746 0.72077554 7.80E-05 0.001036573 ZKSCAN3 ENSG00000189298 421.2440908 -0.822527157 7.81E-05 0.001036712 UNC45A ENSG00000140553 3865.649031 -0.523465229 7.84E-05 0.001039912 NCBP3 ENSG00000074356 4755.702344 0.658911978 7.88E-05 0.001044319 SUGP1 ENSG00000105705 2983.624065 -0.422313297 7.90E-05 0.0010467 COG4 ENSG00000103051 3688.618925 -0.518404456 7.91E-05 0.001046825 NDUFS6 ENSG00000145494 3454.945249 0.44912511 7.95E-05 0.001049827 ARFRP1 ENSG00000101246 1857.472986 -0.56831737 8.05E-05 0.001061848 ZBTB21 ENSG00000173276 1836.352587 0.814005669 8.06E-05 0.001062519 GAREM1 ENSG00000141441 66.59542178 1.030640269 8.07E-05 0.001062519 SORT1 ENSG00000134243 7659.919787 0.854065654 8.11E-05 0.001067011 HPS6 ENSG00000166189 1327.617476 -0.633646373 8.16E-05 0.001072477 RALGAPA2 ENSG00000188559 7017.494806 0.684264383 8.19E-05 0.00107479 NARFL ENSG00000103245 1923.465934 -0.488898694 8.20E-05 0.00107515 FAM188A ENSG00000148481 3694.405071 0.616260632 8.23E-05 0.001077796 HK2 ENSG00000159399 7307.502609 0.698315131 8.35E-05 0.001091852 TEPSIN ENSG00000167302 5514.309093 -0.470472551 8.39E-05 0.001095503 SIX5 ENSG00000177045 62.79461473 -1.510695054 8.41E-05 0.001097747 BLOC1S2 ENSG00000196072 3580.663978 0.517686292 8.42E-05 0.001098352 IMPAD1 ENSG00000104331 6032.998242 0.603204148 8.43E-05 0.001098816 GRIK1 ENSG00000171189 76.44448608 1.005873767 8.53E-05 0.001109794 PIK3CA ENSG00000121879 5546.460499 0.454146044 8.60E-05 0.001118624 TBXAS1 ENSG00000059377 17905.6865 0.730321453 8.70E-05 0.001130091 SPRED2 ENSG00000198369 432.9937556 0.953342366 8.73E-05 0.001133099 STK32B ENSG00000152953 166.4944186 0.890563492 8.87E-05 0.001149268 FAM102B ENSG00000162636 4594.083404 0.643214005 8.94E-05 0.001156701 SMURF1 ENSG00000198742 3729.090826 0.693758868 8.95E-05 0.001157412 CHMP2B ENSG00000083937 3579.211057 0.788267634 8.96E-05 0.001158056 UBTF ENSG00000108312 11076.59813 -0.430527301 9.03E-05 0.001164313 CDH5 ENSG00000179776 48.62076808 1.880747801 9.11E-05 0.001170245 QSER1 ENSG00000060749 2160.818428 0.556416787 9.13E-05 0.001171676 GTPBP3 ENSG00000130299 1111.220638 -0.607109513 9.21E-05 0.001180171 TMED5 ENSG00000117500 8518.537044 0.576311693 9.22E-05 0.001181384 PPIAL4G ENSG00000236334 15.83441942 -1.517820943 9.23E-05 0.001181774 FCRL6 ENSG00000181036 3579.180001 -1.111572229 9.27E-05 0.00118613 DOC2B ENSG00000272636 230.8883579 1.794421419 9.31E-05 0.001190301 NFYB ENSG00000120837 1512.017303 -0.398092027 9.43E-05 0.001203513 CCDC88B ENSG00000168071 26312.63025 -0.552660184 9.45E-05 0.001205942 SLC30A9 ENSG00000014824 3061.662773 0.627927194 9.51E-05 0.001212262 SUCO ENSG00000094975 2852.9228 0.624965267 9.54E-05 0.001214674

PPDPF ENSG00000125534 2406.620301 -0.727318789 9.54E-05 0.001214674 STAU1 ENSG00000124214 8061.26183 0.371296243 9.57E-05 0.001216171 KLC2 ENSG00000174996 1647.026073 -0.620246892 9.57E-05 0.001216475 PLEKHJ1 ENSG00000104886 1144.432208 -0.556019891 9.63E-05 0.001223125 RDX ENSG00000137710 1573.957558 0.465590004 9.73E-05 0.001232296 NRAS ENSG00000213281 7571.086104 0.809303749 9.80E-05 0.001238767 PLEKHF1 ENSG00000166289 969.1461168 -1.249688164 9.80E-05 0.001238767 GKAP1 ENSG00000165113 489.5619975 -0.570929387 9.79E-05 0.001238767 SNRNP70 ENSG00000104852 16056.18956 -0.354753868 9.83E-05 0.00124138 HIRIP3 ENSG00000149929 1071.703209 -0.704650438 9.90E-05 0.00124926 EDNRB ENSG00000136160 62.7409661 1.807822982 9.91E-05 0.001249857 HLX ENSG00000136630 2142.963301 0.907954535 9.98E-05 0.001258605 DNASE1L3 ENSG00000163687 84.32288196 -1.826648785 0.000100494 0.001266431 NOS3 ENSG00000164867 156.7655375 -0.878274436 0.000100652 0.001267122 SCLT1 ENSG00000151466 4344.609241 0.68226351 0.000101114 0.001272129 F3 ENSG00000117525 51.69931582 1.832543071 0.000101503 0.001275885 R3HDM1 ENSG00000048991 3645.310203 0.350039794 0.000101574 0.001276134 GDPD5 ENSG00000158555 3676.053802 -0.809516765 0.000102139 0.001281923 IFNG ENSG00000111537 417.7549311 -1.331113177 0.000102429 0.001284915 FLT3 ENSG00000122025 3378.809246 1.669585146 0.000103198 0.001293246 TBC1D15 ENSG00000121749 4197.958539 0.713224938 0.00010345 0.001295752 DEK ENSG00000124795 11364.73792 0.693493158 0.000103606 0.001297048 EPB42 ENSG00000166947 576.1217272 1.563730263 0.000104961 0.001310686 RPL12 ENSG00000197958 78836.70678 -0.406624982 0.000105318 0.001314479 LLGL2 ENSG00000073350 3608.021058 -1.111377916 0.000106098 0.001322211 CENPBD1 ENSG00000177946 424.6405932 -0.767509005 0.000106384 0.00132377 FNIP2 ENSG00000052795 3021.624229 0.640842871 0.000107279 0.001333222 MIEF2 ENSG00000177427 290.5209468 -0.885790706 0.000107359 0.001333222 CPNE8 ENSG00000139117 2333.715778 0.878796685 0.000107597 0.001335496 PCOLCE2 ENSG00000163710 88.84825799 1.854711112 0.000107673 0.001335778 HCN2 ENSG00000099822 113.9219739 -1.033607865 0.000107927 0.001337576 KTN1 ENSG00000126777 12712.08788 0.325206098 0.00010811 0.001339178 PJA2 ENSG00000198961 12483.25593 0.565079667 0.000108247 0.001340203 LAPTM5 ENSG00000162511 192015.3161 0.50317931 0.000108529 0.001342345 SEMA4G ENSG00000095539 163.6127923 -0.610988236 0.000108485 0.001342345 GPR137 ENSG00000173264 726.9431128 -0.484950176 0.000108918 0.001345655 PDZD8 ENSG00000165650 3852.069186 1.082347987 0.00010887 0.001345655 TMEM94 ENSG00000177728 5036.487128 -0.366287269 0.000109036 0.00134592 CD2 ENSG00000116824 9499.330166 -0.818343038 0.000109752 0.00135408 TNFRSF14 ENSG00000157873 14231.03958 -0.516591692 0.000110583 0.001362977 TLK1 ENSG00000198586 6052.92518 0.52295494 0.000111769 0.001376224 RAD1 ENSG00000113456 1324.851231 -0.420630665 0.000112431 0.001381613 FAM173A ENSG00000103254 467.4418208 -1.083896608 0.000113593 0.001392427 FAM117A ENSG00000121104 7467.54392 -0.79425429 0.000113904 0.001395551 FBXL16 ENSG00000127585 572.132043 -1.081411975 0.000114525 0.001401762 TPK1 ENSG00000196511 1533.081273 0.653220784 0.000114601 0.001402009

SNN ENSG00000184602 13079.80334 0.683406606 0.000114827 0.001404078 NMB ENSG00000197696 120.4147332 -0.687199697 0.000116327 0.001419604 AARS2 ENSG00000124608 1333.912814 -0.647772979 0.000116482 0.001420709 PROCR ENSG00000101000 124.1857346 -0.77795777 0.000116535 0.001420709 MMS19 ENSG00000155229 5682.521498 -0.231850707 0.000117438 0.00142822 TSR3 ENSG00000007520 1419.470237 -0.5913054 0.000117407 0.00142822 FAM133B ENSG00000234545 1695.352416 0.682432989 0.000117752 0.001430701 GPAA1 ENSG00000197858 2674.60125 -0.506789346 0.000117758 0.001430701 AIMP1 ENSG00000164022 4706.446389 0.303553296 0.000118025 0.001433245 KLHL29 ENSG00000119771 404.5851334 1.28450226 0.000118282 0.001434252 TFAP4 ENSG00000090447 772.4251798 -0.674380826 0.000118914 0.001439786 GSTA4 ENSG00000170899 93.18183687 -0.865378362 0.000119144 0.001441873 MADCAM1 ENSG00000099866 40.73067251 -1.142034572 0.000119399 0.001444245 C12orf73 ENSG00000204954 218.1772181 -0.516495163 0.00012062 0.001456807 REEP6 ENSG00000115255 135.2153779 -0.916805483 0.000120673 0.001456807 NOSIP ENSG00000142546 5507.274377 -0.694078465 0.000120773 0.001457305 NENF ENSG00000117691 909.5335259 -0.701328815 0.000121419 0.001464377 BCAT2 ENSG00000105552 1077.864162 -0.606740959 0.00012265 0.001476344 PPP1R1A ENSG00000135447 63.91685285 0.900462357 0.000122928 0.001478246 KLHDC3 ENSG00000124702 6032.336144 -0.37494128 0.000123611 0.00148469 VPS26B ENSG00000151502 9236.906043 -0.337201119 0.000124077 0.001487723 DPH7 ENSG00000148399 2100.73173 -0.481162933 0.000124318 0.001488439 FCHO1 ENSG00000130475 3973.483431 -0.492636679 0.00012508 0.001496109 CPNE5 ENSG00000124772 1725.767601 -0.871606859 0.000125319 0.001498248 CD63 ENSG00000135404 14125.35635 0.750873417 0.000126657 0.001509942 DENND5A ENSG00000184014 14261.26577 0.467034225 0.000126686 0.001509942 NDRG2 ENSG00000165795 689.8142211 -0.720273814 0.000127246 0.00151542 TXNL4B ENSG00000140830 1235.374072 -0.467648442 0.000127385 0.001516347 PLAU ENSG00000122861 158.6426076 1.453451066 0.000127665 0.001518938 TNFSF8 ENSG00000106952 4871.113637 0.587858969 0.000128292 0.001525672 CDC42 ENSG00000070831 39582.11734 0.369815789 0.000128893 0.001531345 UGGT2 ENSG00000102595 575.0062805 0.875666758 0.000129093 0.001532983 CPEB3 ENSG00000107864 1035.671629 0.709665047 0.000129448 0.001536458 OAT ENSG00000065154 3700.65401 0.526965296 0.000129793 0.001539077 MTRNR2L8 ENSG00000255823 132.4603169 0.962287153 0.000130109 0.001541342 PPP1R3G ENSG00000219607 33.40774906 -1.295341032 0.000130826 0.001549086 EVL ENSG00000196405 27810.01712 -0.709099376 0.000131366 0.001553989 CTD-2547L24.3 ENSG00000258875 458.8899963 -0.706947841 0.000131358 0.001553989 RNF145 ENSG00000145860 4151.371608 0.556914243 0.00013185 0.001558443 INHBA ENSG00000122641 159.757036 1.806772325 0.000132913 0.001568542 PRKACA ENSG00000072062 12021.15205 0.514910753 0.000132878 0.001568542 FAM122A ENSG00000187866 1523.692457 -0.501212105 0.000133743 0.001577574 CTB-50L17.10 ENSG00000167674 2690.580274 -0.426417882 0.000134821 0.001588026 HTRA2 ENSG00000115317 1496.022195 -0.586408499 0.000135403 0.001592602 TRAK1 ENSG00000182606 7422.690202 0.35840584 0.000138357 0.001624247 ATP8B4 ENSG00000104043 1972.547972 0.966486483 0.000138729 0.001626296

USP6NL ENSG00000148429 2512.80239 0.766978216 0.000138855 0.001627001 PLXNA2 ENSG00000076356 669.7150999 0.868835963 0.00013895 0.001627348 MUS81 ENSG00000172732 2461.229676 -0.469820486 0.000139536 0.001633426 ERLIN2 ENSG00000147475 2706.087097 0.480936347 0.000140524 0.001642657 MPI ENSG00000178802 2393.887458 -0.69016014 0.000142979 0.0016672 GNS ENSG00000135677 25712.02616 0.663261835 0.000144012 0.001676299 DDX60L ENSG00000181381 11627.10338 0.646093345 0.000147158 0.001711305 MSR1 ENSG00000038945 1796.965645 1.143003804 0.000148325 0.00172279 C10orf128 ENSG00000204161 1027.776008 -0.970500981 0.000148572 0.001722874 BCDIN3D ENSG00000186666 317.006209 -0.812583232 0.00014911 0.001726686 MAP2K1 ENSG00000169032 8521.89179 0.508758597 0.000149777 0.001733332 BNIP1 ENSG00000113734 845.4643273 0.522300473 0.000149824 0.001733332 MTM1 ENSG00000171100 1759.62772 0.655164343 0.000150047 0.001735097 ZC3H7A ENSG00000122299 8709.13256 0.52044681 0.000150293 0.00173713 WDR90 ENSG00000161996 686.5969237 -0.590900311 0.000151368 0.001747916 TTC16 ENSG00000167094 1320.492749 -1.033684428 0.000152284 0.001756851 EP300 ENSG00000100393 8675.915931 0.841863964 0.00015238 0.001757131 CTTNBP2 ENSG00000077063 83.56393163 1.64301236 0.000152505 0.001757616 IL1R1 ENSG00000115594 2050.153295 1.44880712 0.000153348 0.001764184 RCOR3 ENSG00000117625 5903.140359 0.382958967 0.000153857 0.001769212 PRMT6 ENSG00000198890 627.5555212 -0.649453727 0.00015403 0.001770379 LIPA ENSG00000107798 18191.14089 0.932559676 0.000154836 0.001778818 ZMYND15 ENSG00000141497 701.6682499 0.802740729 0.000155207 0.001782243 PPIP5K2 ENSG00000145725 5294.906934 0.638372851 0.000155972 0.001788532 TMTC2 ENSG00000179104 1678.801685 0.623155025 0.000157946 0.001806973 ACSF2 ENSG00000167107 1155.976751 -0.398554106 0.000158894 0.001815872 NFKB1 ENSG00000109320 7597.636466 0.33088744 0.000159226 0.001818248 USP25 ENSG00000155313 8014.294822 0.405109442 0.000160044 0.001824413 OLA1 ENSG00000138430 3973.746058 0.430958861 0.000159955 0.001824413 TAF9B ENSG00000187325 1536.145724 0.573001314 0.000162289 0.001844703 BNIP3L ENSG00000104765 14153.18006 0.808716213 0.000162629 0.001845602 FUZ ENSG00000010361 799.2516965 -0.465408764 0.000162667 0.001845602 RAP1B ENSG00000127314 28942.43724 0.44030562 0.000162884 0.001847216 LONRF1 ENSG00000154359 2468.739956 0.770988445 0.000163384 0.001851184 GZMK ENSG00000113088 3671.997064 -1.049610841 0.000163695 0.001851314 EEF2KMT ENSG00000118894 538.1632904 -0.673401663 0.000165139 0.001865934 PPP1R35 ENSG00000160813 1344.47565 -0.645707105 0.000165986 0.001874652 CEP131 ENSG00000141577 1280.549881 -0.605238045 0.00016626 0.001876818 TRIM47 ENSG00000132481 134.3127603 -1.119056114 0.000166966 0.001883128 SSBP3 ENSG00000157216 5604.07496 -0.456434128 0.000168615 0.001899846 SASH1 ENSG00000111961 1657.566776 1.082117436 0.000168759 0.001899889 TCTEX1D1 ENSG00000152760 150.8713545 1.618454305 0.000169216 0.001903295 PQBP1 ENSG00000102103 3192.035385 -0.364429933 0.000171047 0.001922135 DEXI ENSG00000182108 248.6925454 -1.267630372 0.000171971 0.001929628 C1orf35 ENSG00000143793 1071.508561 -0.629397937 0.000172044 0.001929628 TRIP10 ENSG00000125733 437.9839233 -0.677304434 0.000171893 0.001929628

C3orf35 ENSG00000198590 190.286124 0.996948512 0.000172104 0.001929628 RNASE1 ENSG00000129538 416.1666932 1.515781026 0.000173396 0.001940592 TIGAR ENSG00000078237 1169.41468 0.496475248 0.000174583 0.001950334 RUSC1 ENSG00000160753 1325.54466 -0.366639127 0.000175812 0.001961407 TMEM143 ENSG00000161558 739.6819711 -0.541811501 0.000176534 0.001968573 RP11-563J2.3 ENSG00000212743 230.6836908 1.100099149 0.000178481 0.001987595 SDC2 ENSG00000169439 202.2510974 1.407938431 0.00017923 0.001994138 GABPA ENSG00000154727 4823.077476 0.444993694 0.000179319 0.001994225 TIMP1 ENSG00000102265 15736.97263 1.060622799 0.00018024 0.002003564 ARSB ENSG00000113273 2687.515868 0.584663297 0.000180753 0.002008362 COL1A1 ENSG00000108821 23.92067468 1.654663435 0.000180927 0.002009393 DOCK4 ENSG00000128512 554.5824994 1.017947129 0.000181402 0.002013761 ADPGK ENSG00000159322 15757.57862 0.443013976 0.000183843 0.002035414 COIL ENSG00000121058 1920.196976 0.380220525 0.000183846 0.002035414 PANK4 ENSG00000157881 1916.854265 -0.378141778 0.000184055 0.002036804 ZNF792 ENSG00000180884 766.2324241 -0.837121547 0.000184774 0.002042935 ASCC3 ENSG00000112249 3628.850964 0.43431988 0.000185063 0.002045219 DCTN2 ENSG00000175203 4546.803311 0.388686031 0.000185372 0.002046797 RRAGD ENSG00000025039 1411.331321 0.780243862 0.000185473 0.002047 PKN1 ENSG00000123143 18664.30164 -0.451027247 0.000187425 0.002065775 TMEM119 ENSG00000183160 166.7762774 1.162627878 0.000188634 0.002078175 APP ENSG00000142192 11754.44166 0.542938273 0.000189061 0.002081947 MCRS1 ENSG00000187778 4239.533623 -0.431617494 0.000189502 0.002084916 FAM89A ENSG00000182118 297.58612 0.889986927 0.000190105 0.002088788 PLK3 ENSG00000173846 5650.211768 1.05553211 0.000191985 0.002105582 PIK3C3 ENSG00000078142 3370.911658 0.601055188 0.000193268 0.002116569 SPTLC2 ENSG00000100596 11747.41046 0.753134414 0.000196394 0.002141688 GRPEL1 ENSG00000109519 3081.360928 0.6586594 0.00019785 0.002155668 TAF2 ENSG00000064313 3444.725439 0.397415501 0.000198057 0.002156971 SPRYD3 ENSG00000167778 2296.49238 -0.62476617 0.00019837 0.002159034 HNRNPK ENSG00000165119 50551.46629 0.246773974 0.000198773 0.002160957 KRBOX4 ENSG00000147121 1030.3466 -0.587985351 0.000199944 0.002172734 NIPSNAP3B ENSG00000165028 136.9491657 -0.556926649 0.00020017 0.002173275 JADE3 ENSG00000102221 312.4337324 0.983743508 0.000201215 0.002182704 RPTOR ENSG00000141564 3024.549804 -0.527542898 0.000201736 0.002187389 TMEM106C ENSG00000134291 873.6967449 -0.565309183 0.000202245 0.002191945 CLK2 ENSG00000176444 7125.724382 -0.305218892 0.000203284 0.002201281 NSG1 ENSG00000168824 985.3317045 -1.009678963 0.000203813 0.002205076 TRUB2 ENSG00000167112 1147.802737 -0.546696506 0.000204041 0.002206577 WDR47 ENSG00000085433 1545.824181 0.44805504 0.000204634 0.002211046 CCDC6 ENSG00000108091 4099.268107 0.620860119 0.0002049 0.002212959 HRAS ENSG00000174775 732.3677054 -0.626407367 0.000205776 0.002218537 LDB1 ENSG00000198728 17000.23916 -0.327252864 0.000205735 0.002218537 DXO ENSG00000204348 1072.108517 -0.527024368 0.000206573 0.002225988 RP11-403I13.8 ENSG00000272419 2447.581213 -0.519448135 0.000206647 0.002225988 CLIC5 ENSG00000112782 264.9323718 -0.769222088 0.000208411 0.002243033

THOC6 ENSG00000131652 1453.788088 -0.464324152 0.00020861 0.002244194 AMOT ENSG00000126016 212.3815486 -0.879693065 0.000208951 0.002246404 INSL6 ENSG00000120210 679.6766633 0.78805839 0.000208997 0.002246404 MAP1LC3B ENSG00000140941 4550.262929 0.717359375 0.000209972 0.002254915 LDHA ENSG00000134333 23427.03352 0.519590713 0.000210529 0.002259911 HAS3 ENSG00000103044 170.4628071 0.780110754 0.000212996 0.002281494 SPPL2A ENSG00000138600 5391.823691 0.412203403 0.000213001 0.002281494 B4GALNT4 ENSG00000182272 74.60701064 -1.596017233 0.000213606 0.002285001 LRMP ENSG00000118308 7925.594917 0.468311674 0.000216547 0.002313453 ZBTB34 ENSG00000177125 4301.259499 0.612147928 0.000217031 0.00231762 MARCH1 ENSG00000145416 6945.174337 0.859194288 0.000217282 0.002319304 RBM10 ENSG00000182872 6351.206429 -0.29844174 0.000217999 0.002324943 FCGR1B ENSG00000198019 565.1195571 0.902279288 0.000219003 0.002334646 OLFM2 ENSG00000105088 121.8947119 -1.437829816 0.000220682 0.002349501 MTRF1L ENSG00000112031 2561.278611 0.399108296 0.000222721 0.00237019 TOMM20 ENSG00000173726 10990.52182 0.261530613 0.000223894 0.002381647 RCVRN ENSG00000109047 127.3093424 1.017043239 0.000224987 0.002390828 RECQL5 ENSG00000108469 1828.140203 -0.370942664 0.000226966 0.002408104 GIT1 ENSG00000108262 4660.303094 -0.433522302 0.000227753 0.002415415 MMP19 ENSG00000123342 150.8164549 1.354401906 0.00022911 0.002427716 GSPT2 ENSG00000189369 615.257457 -0.490461487 0.000230439 0.00243971 CTSG ENSG00000100448 803.0700264 1.661737222 0.000231489 0.002448723 SCARB2 ENSG00000138760 8597.965452 0.613337477 0.00023232 0.002454363 ZNF584 ENSG00000171574 200.4988271 -0.788502099 0.000233161 0.00246114 PRR14 ENSG00000156858 4069.834225 -0.420139745 0.00023386 0.002466409 GRAP ENSG00000154016 2169.113434 -0.84395759 0.000234435 0.002471428 APEX2 ENSG00000169188 915.6901992 -0.834277497 0.000234566 0.002471745 HNRNPH1 ENSG00000169045 31818.13952 0.361351632 0.000235623 0.00248077 RPL35 ENSG00000136942 42032.72688 -0.497306451 0.000236023 0.002483872 CWF19L1 ENSG00000095485 4080.350889 0.539428623 0.000236119 0.002483872 BPI ENSG00000101425 6164.015814 1.671185816 0.000236805 0.002487815 MTMR6 ENSG00000139505 5208.756716 0.657487647 0.000236997 0.002487815 DDIT4 ENSG00000168209 16922.59317 1.245761792 0.000236986 0.002487815 CYBB ENSG00000165168 91392.8843 0.885491547 0.000237589 0.002491908 LAMC1 ENSG00000135862 1006.28579 1.211744725 0.000237788 0.002492937 HES4 ENSG00000188290 170.9301677 -1.364986414 0.000239392 0.002506564 CLCN5 ENSG00000171365 1676.126674 0.828448593 0.00023931 0.002506564 KLF11 ENSG00000172059 8273.484291 0.613844525 0.000240261 0.002512463 SLC16A11 ENSG00000174326 48.38569146 -1.127188594 0.00024063 0.002515262 MSRB3 ENSG00000174099 396.7541728 1.157791063 0.000242694 0.002532833 BRCA2 ENSG00000139618 336.8881383 1.074664469 0.000244537 0.002549626 SCX ENSG00000260428 77.18398515 -1.092168068 0.000245009 0.002553216 AES ENSG00000104964 31361.12534 -0.505812139 0.000245205 0.002553354 PSMD7 ENSG00000103035 7496.676484 0.345261213 0.000245374 0.002554041 RPS6KA4 ENSG00000162302 3930.353489 -0.49075935 0.000245612 0.002555443 XCL1 ENSG00000143184 209.4902407 -1.108490541 0.000247834 0.002576385

RPA1 ENSG00000132383 5567.611879 -0.364392939 0.000248711 0.002584415 ALS2CL ENSG00000178038 974.7088122 -0.88375722 0.000249333 0.002587612 NBN ENSG00000104320 4848.098873 0.511586925 0.000250438 0.002597997 SLC22A4 ENSG00000197208 2148.405812 1.018983635 0.000252768 0.002619965 SCNN1A ENSG00000111319 102.0983142 0.842431085 0.000252996 0.002621222 ZSWIM3 ENSG00000132801 200.4713022 -0.807303581 0.000253866 0.002628032 KLC4 ENSG00000137171 1214.298025 -0.380504231 0.00025439 0.002632356 ATXN1 ENSG00000124788 5108.335462 0.576908172 0.000255443 0.002641043 GRINA ENSG00000178719 7215.279806 0.660180399 0.000256282 0.002648601 FAHD2A ENSG00000115042 1427.195824 -0.426257278 0.000256441 0.00264914 C4orf48 ENSG00000243449 207.9894546 -1.248181421 0.000257195 0.002655821 SOX13 ENSG00000143842 861.2187266 -1.084668111 0.00025762 0.002659093 ZNF202 ENSG00000166261 1758.286898 -0.531648135 0.000258019 0.002661231 THOP1 ENSG00000172009 1535.659603 -0.565478735 0.000258141 0.002661231 SMURF2 ENSG00000108854 3084.317462 0.367817287 0.00025839 0.002662596 CDC42BPB ENSG00000198752 2931.16728 0.474415615 0.000258719 0.002664867 TNFAIP3 ENSG00000118503 47763.37611 1.049022021 0.00026159 0.002692196 PYGL ENSG00000100504 16072.75867 0.834273382 0.000264406 0.002716261 FBLN5 ENSG00000140092 354.8657053 -1.11970243 0.000268199 0.002748766 RRP9 ENSG00000114767 834.9742202 -0.495052454 0.000268534 0.002751054 POLM ENSG00000122678 2419.124479 -0.60254158 0.00026911 0.002755815 FBN1 ENSG00000166147 145.5951747 1.286116843 0.00027081 0.002772071 PRKCZ ENSG00000067606 851.1087982 -0.538418586 0.000271178 0.002774692 ZBTB10 ENSG00000205189 1243.081988 0.780867861 0.000274065 0.002798431 ZBTB12 ENSG00000204366 76.46238605 -1.180227279 0.000276002 0.002815885 RNF167 ENSG00000108523 7545.145854 -0.506034002 0.000276249 0.002816384 F12 ENSG00000131187 258.5079806 0.949123473 0.000276326 0.002816384 PRTN3 ENSG00000196415 379.3785828 1.777772677 0.000276659 0.002817929 GAS1 ENSG00000180447 38.57361933 -1.402116053 0.000277538 0.002825713 SLC2A8 ENSG00000136856 301.4639404 -0.712166137 0.000278799 0.002835046 FLT4 ENSG00000037280 314.201995 -0.899879487 0.000279801 0.002842896 GPNMB ENSG00000136235 270.3021707 1.301789399 0.000280391 0.002846546 RNF19A ENSG00000034677 9096.134546 0.614511948 0.000280752 0.002849043 EPC2 ENSG00000135999 5579.894697 0.506545008 0.000280983 0.002850055 HIPK3 ENSG00000110422 16756.26396 0.596759656 0.000282139 0.002858418 FLJ20021 ENSG00000254531 192.9370066 -0.671399702 0.000284157 0.002876507 ZNF517 ENSG00000197363 716.3709911 -0.712783741 0.000284661 0.002879244 RUVBL2 ENSG00000183207 2454.776203 -0.471070884 0.000285804 0.002888445 RBM3 ENSG00000102317 23756.53757 0.429450572 0.000286317 0.002891697 ZDHHC2 ENSG00000104219 3064.491008 0.788476934 0.00028636 0.002891697 XRCC4 ENSG00000152422 961.385466 0.620427171 0.000290566 0.002931775 UBE2I ENSG00000103275 6800.334809 0.378235819 0.00029126 0.00293324 ATP13A1 ENSG00000105726 7870.225607 -0.36299712 0.000291305 0.00293324 C16orf91 ENSG00000174109 409.8797396 -0.645302223 0.000291142 0.00293324 COPS3 ENSG00000141030 2712.607524 0.482460924 0.00029269 0.002944785 FUT2 ENSG00000176920 52.11962632 -1.046488994 0.000293668 0.002953422

FUK ENSG00000157353 2140.339847 -0.55215331 0.000294765 0.002963249 HEXB ENSG00000049860 10361.44808 0.585466107 0.000294968 0.002964079 ARID5B ENSG00000150347 3418.351202 0.800858403 0.000297171 0.002983787 FCMR ENSG00000162894 6986.314481 -0.643644746 0.000298174 0.002991424 PUF60 ENSG00000179950 4865.152897 -0.432710102 0.000298394 0.002992416 PTGER2 ENSG00000125384 11644.52789 0.638703565 0.000299672 0.003000364 TFG ENSG00000114354 4453.439325 0.481160024 0.000301276 0.003011537 ERP44 ENSG00000023318 9166.566763 0.390676136 0.000302889 0.00302644 RBM39 ENSG00000131051 27058.03537 0.405670578 0.000303545 0.003031767 UQCC3 ENSG00000204922 486.3637354 -0.73354837 0.00030406 0.003035471 PPP2R5B ENSG00000068971 1986.014783 -0.352092523 0.000304287 0.0030355 RAC2 ENSG00000128340 36858.1188 -0.402930588 0.000304489 0.00303629 NMUR1 ENSG00000171596 2642.457596 -1.290165319 0.0003051 0.003039922 WTAP ENSG00000146457 14240.59679 0.470264397 0.000305641 0.00304409 QSOX1 ENSG00000116260 9229.796567 0.655406037 0.000306404 0.003048437 PSMD11 ENSG00000108671 4753.148486 0.497278837 0.000306448 0.003048437 SLC1A3 ENSG00000079215 224.0526575 1.362943748 0.000306651 0.00304923 ACAT2 ENSG00000120437 1175.918614 -0.465398018 0.00030796 0.003059783 PRPF6 ENSG00000101161 8617.383798 -0.356674916 0.000310356 0.003082345 HINFP ENSG00000172273 1842.501616 -0.383443679 0.00031191 0.003093737 BTBD1 ENSG00000064726 6686.588827 0.347806909 0.000313985 0.003110882 ZNF516 ENSG00000101493 3771.296164 0.915738916 0.000315594 0.003125567 ITM2C ENSG00000135916 2192.536934 -0.846043976 0.000316262 0.003130926 ECI2 ENSG00000198721 2245.853953 -0.434979327 0.00031697 0.003136625 BCCIP ENSG00000107949 3334.368989 0.320078836 0.000317421 0.003138633 VSTM1 ENSG00000189068 1748.49642 1.062674609 0.000317703 0.003138743 ZNF420 ENSG00000197050 428.246137 -0.897955328 0.000317814 0.003138743 ENDOD1 ENSG00000149218 1439.046757 -0.628894908 0.000320557 0.003160779 CHD7 ENSG00000171316 3276.587668 0.928551472 0.000323307 0.00318281 MPP7 ENSG00000150054 4980.359553 0.791628784 0.000323251 0.00318281 CBX3 ENSG00000122565 5276.685185 0.391103168 0.000326875 0.00321666 STOX2 ENSG00000173320 81.26378056 1.644395752 0.000327573 0.003222243 PFKL ENSG00000141959 12399.62517 -0.387343175 0.000328122 0.003225074 DHX16 ENSG00000204560 5123.057966 -0.311319548 0.000328309 0.003225357 PRUNE2 ENSG00000106772 389.4185315 1.234941943 0.000328412 0.003225357 MLNR ENSG00000102539 53.68154971 1.747345497 0.000331623 0.003251723 DNAJB6 ENSG00000105993 10889.52827 0.567851803 0.000332382 0.003256579 MARK3 ENSG00000075413 9979.51746 0.26171134 0.000333287 0.003261566 ZSCAN32 ENSG00000140987 1041.637629 -0.738540743 0.000335373 0.003276784 GFI1B ENSG00000165702 305.0811984 -0.940316487 0.000337298 0.003294287 PATL1 ENSG00000166889 8290.969736 0.592680329 0.000337436 0.003294331 CCHCR1 ENSG00000204536 1213.780229 -0.450627564 0.000338668 0.003305058 VAC14 ENSG00000103043 2546.213562 -0.35097813 0.000339907 0.003315835 JAKMIP1 ENSG00000152969 1397.540924 -0.929560443 0.000340469 0.00332001 ZNF436 ENSG00000125945 796.7826704 -0.484004227 0.000341114 0.003324988 NUP155 ENSG00000113569 2115.052901 0.492932591 0.000342895 0.003335762

SEH1L ENSG00000085415 1927.325469 0.424109777 0.000344063 0.003345806 TMEM52B ENSG00000165685 30.52120981 1.733049021 0.000344744 0.003351114 HECTD1 ENSG00000092148 9716.26271 0.426723966 0.000347504 0.00337263 UBA7 ENSG00000182179 11566.9628 -0.389229927 0.000347928 0.003375425 ACAP3 ENSG00000131584 5770.503409 -0.531785304 0.000348728 0.003379069 TMEM150A ENSG00000168890 859.2677661 -0.513195082 0.000348851 0.003379069 WDR24 ENSG00000127580 833.8643585 -0.489080686 0.000349325 0.003382334 AKT1 ENSG00000142208 9769.724501 -0.475955244 0.000350114 0.003388647 CTDSPL2 ENSG00000137770 3295.66096 0.571954163 0.0003505 0.003391052 TNFRSF12A ENSG00000006327 303.4516829 1.250987639 0.000351266 0.003397128 PPA2 ENSG00000138777 2462.361989 0.314722772 0.000351896 0.003400744 FRMPD3 ENSG00000147234 466.4358883 -1.009301047 0.000351915 0.003400744 DNAJC19 ENSG00000205981 989.3995168 -0.372861592 0.000355041 0.003428265 LIN7C ENSG00000148943 2517.230822 0.48399799 0.000357012 0.00344326 RAB1A ENSG00000138069 6833.987768 0.801169948 0.000357667 0.00344823 SURF2 ENSG00000148291 719.5488358 -0.456042344 0.000358325 0.003451488 NDUFB7 ENSG00000099795 2599.442344 -0.619810187 0.00035886 0.003453846 DRD4 ENSG00000069696 25.1086717 -1.170465745 0.000358948 0.003453846 RDH12 ENSG00000139988 18.35337463 1.181337089 0.000359655 0.00345661 PRPF4B ENSG00000112739 11284.83189 0.442715983 0.000361573 0.003472339 CCNT2 ENSG00000082258 5938.282389 0.500934461 0.000363958 0.003491166 WRNIP1 ENSG00000124535 4763.340308 -0.263021406 0.000363939 0.003491166 STT3B ENSG00000163527 12089.13466 0.478980524 0.000363727 0.003491166 C17orf67 ENSG00000214226 871.1959617 -0.456947672 0.000365499 0.003503227 KLF14 ENSG00000266265 11.87287697 1.668502049 0.00036686 0.003513548 POLL ENSG00000166169 1367.155753 -0.519169581 0.000368814 0.003529529 GID8 ENSG00000101193 6105.959182 0.336013976 0.000371693 0.00355157 C14orf79 ENSG00000140104 128.3668773 -0.675654627 0.000372033 0.003552071 LRFN4 ENSG00000173621 506.3236418 -0.799292371 0.00037189 0.003552071 VRK3 ENSG00000105053 3618.643519 -0.284157325 0.000372841 0.003558409 OST4 ENSG00000228474 6410.075338 -0.530114475 0.00037355 0.003560857 KREMEN1 ENSG00000183762 739.0952044 1.300608501 0.000373674 0.003560857 STUB1 ENSG00000103266 2320.126736 -0.498222228 0.000373554 0.003560857 PSMG3 ENSG00000157778 1044.797668 -0.5844262 0.000374016 0.00356274 SAMD10 ENSG00000130590 913.4305388 -0.763438136 0.000378117 0.003592111 MCM7 ENSG00000166508 6864.772424 -0.527582221 0.000379661 0.003604006 SPAG9 ENSG00000008294 6291.183023 0.577499733 0.000380779 0.003611847 LY9 ENSG00000122224 4311.484805 -0.718071148 0.000382201 0.003622548 PCMTD1 ENSG00000168300 10436.64931 0.471699918 0.000382962 0.003627125 KLHL36 ENSG00000135686 4761.255829 -0.51795171 0.000385419 0.003646052 ANXA3 ENSG00000138772 3583.870367 1.598258159 0.000388942 0.003675643 ANO9 ENSG00000185101 4065.062961 -0.759625924 0.00039472 0.003724057 STAB1 ENSG00000010327 31141.9519 0.951408007 0.000395094 0.003724899 SELENOW ENSG00000178980 3691.967233 -0.496496507 0.000395111 0.003724899 CTSW ENSG00000172543 14374.95309 -1.084881015 0.000396327 0.003733512 EIF3G ENSG00000130811 14944.43602 -0.32403993 0.000400629 0.003765429

TCEB3 ENSG00000011007 4433.423386 0.424490036 0.000402534 0.003780448 IQGAP3 ENSG00000183856 131.4298548 1.455788224 0.000402866 0.003782131 CAPZA2 ENSG00000198898 6128.824214 0.763667281 0.000404715 0.003789411 ARFGEF1 ENSG00000066777 7361.578407 0.447284209 0.000404149 0.003789411 MAN1A1 ENSG00000111885 11113.05979 0.640837715 0.000404328 0.003789411 ZNF644 ENSG00000122482 2329.403445 0.56335092 0.000404179 0.003789411 FANCG ENSG00000221829 859.4378288 -0.611207207 0.000404686 0.003789411 MBIP ENSG00000151332 1427.415857 0.464514052 0.000405102 0.003791591 RBP7 ENSG00000162444 3127.396548 0.870740534 0.000411718 0.003849143 SWI5 ENSG00000175854 595.1269465 -0.423754041 0.000412576 0.003855702 POLD2 ENSG00000106628 1310.785422 -0.482442174 0.000413404 0.00386198 RGPD5 ENSG00000015568 1905.797575 0.721876317 0.000413615 0.003862487 OSBPL8 ENSG00000091039 12451.133 0.517043844 0.000414343 0.00386783 SMG9 ENSG00000105771 2739.086552 -0.36596563 0.00041517 0.003871157 DLK2 ENSG00000171462 791.0350899 0.630236002 0.000416105 0.003876953 PER2 ENSG00000132326 1359.457637 0.525051195 0.000416528 0.003877771 C10orf11 ENSG00000148655 392.1382726 0.757387056 0.000416664 0.003877771 WNK1 ENSG00000060237 18716.75413 0.504707472 0.000419319 0.003895143 RREB1 ENSG00000124782 4565.452295 0.565021312 0.000420167 0.003900917 RAB8B ENSG00000166128 9170.186604 1.193264422 0.000421541 0.003908971 ZFP64 ENSG00000020256 808.338669 -0.54233671 0.000422448 0.003915372 HOXB2 ENSG00000173917 797.7476794 -0.793342043 0.000423531 0.003922468 ARPP19 ENSG00000128989 10657.91534 0.434507723 0.00042466 0.003929977 GPSM1 ENSG00000160360 306.1180309 -0.817795362 0.000425172 0.003932546 BATF ENSG00000156127 1382.799929 -0.718537678 0.000425256 0.003932546 CDADC1 ENSG00000102543 1089.334184 0.536779966 0.000426021 0.003938143 FOXN2 ENSG00000170802 2449.420237 0.91785291 0.000429112 0.003960787 SPATC1 ENSG00000186583 115.8014918 1.134227499 0.000431269 0.003977725 NUDT8 ENSG00000167799 58.42554739 -1.089493737 0.000434796 0.004002682 NBPF3 ENSG00000142794 611.9595013 -0.979464547 0.000438427 0.004028705 C1orf216 ENSG00000142686 1065.885928 -0.554850049 0.000439123 0.004033597 EMB ENSG00000170571 31670.04948 0.611580527 0.000444855 0.004084728 TRMT13 ENSG00000122435 2762.683765 -0.597315907 0.000448226 0.004111097 FRMD4B ENSG00000114541 2074.919753 0.677436958 0.000448677 0.004112093 ZFAND5 ENSG00000107372 25734.47639 0.727507406 0.000449167 0.004113612 STX1A ENSG00000106089 371.7847923 -0.848140783 0.000451695 0.004135234 ING5 ENSG00000168395 2294.777114 -0.493760922 0.000452306 0.004139297 ICAM4 ENSG00000105371 189.1468931 -0.978339811 0.000452534 0.004139847 ZNF330 ENSG00000109445 3918.580737 0.51757888 0.000455299 0.004162058 SPATA33 ENSG00000167523 306.2730553 -0.458936749 0.000455553 0.004162839 BCL11A ENSG00000119866 1774.512289 0.620791424 0.000456208 0.004164205 FCHO2 ENSG00000157107 2784.435365 0.799719697 0.00046024 0.004190167 FNDC3A ENSG00000102531 6758.938771 0.568777191 0.000461157 0.00419648 SELL ENSG00000188404 67695.12463 0.615883434 0.000461273 0.00419648 LRRC56 ENSG00000161328 236.9986021 -0.776454323 0.000462873 0.004206391 DOK2 ENSG00000147443 11502.20081 -0.606879942 0.000463297 0.004208697

ZNF287 ENSG00000141040 333.7057638 -0.795727844 0.000465028 0.004218209 MAP4K2 ENSG00000168067 5670.635989 -0.378017356 0.000467668 0.004240599 GAK ENSG00000178950 14897.12153 -0.237329089 0.000468736 0.004248729 CACTIN ENSG00000105298 2140.881529 -0.432120217 0.000471637 0.004268753 STYK1 ENSG00000060140 183.3560644 -0.904940602 0.000475047 0.004296466 CETN3 ENSG00000153140 336.5768542 -0.831499517 0.000476409 0.004307215 RHOBTB2 ENSG00000008853 1333.152621 -0.564985617 0.000477927 0.004317774 TNFSF4 ENSG00000117586 265.2708902 -0.753583537 0.000478989 0.004322623 CTNNA1 ENSG00000044115 10341.86303 0.569153613 0.000480087 0.004330951 YIF1A ENSG00000174851 1138.373657 -0.503547745 0.000480746 0.004333731 PGS1 ENSG00000087157 4444.285042 0.7189712 0.00048573 0.004373873 FAM207A ENSG00000160256 929.4950716 -0.527049645 0.000486092 0.00437554 MAGEE1 ENSG00000198934 507.4888632 -0.905979062 0.000487045 0.004382177 HUS1 ENSG00000136273 2424.855403 0.443317955 0.000488228 0.004389961 ALB ENSG00000163631 15.53764887 1.637407277 0.000489139 0.004394825 KIAA0232 ENSG00000170871 6907.558478 0.468595747 0.000489302 0.004394825 SYNJ1 ENSG00000159082 3666.947546 0.633370671 0.000489662 0.004396453 MPC1 ENSG00000060762 3383.806937 0.434986595 0.000490684 0.004400834 GYPA ENSG00000170180 17.51017303 1.768280472 0.00049063 0.004400834 CA11 ENSG00000063180 541.3526788 -1.062101779 0.000491298 0.004404744 RAPH1 ENSG00000173166 106.0601808 1.025734148 0.000491531 0.004405232 NIPBL ENSG00000164190 12987.85722 0.435506424 0.000493298 0.004419468 RNASEH2C ENSG00000172922 3088.510766 -0.495061905 0.000494666 0.004430114 GTF2B ENSG00000137947 2852.653608 0.455063202 0.000495525 0.004432983 LENG1 ENSG00000105617 929.5812204 -0.464845982 0.000497009 0.004443037 SSNA1 ENSG00000176101 1426.842356 -0.730913041 0.000498383 0.004452104 ZNF485 ENSG00000198298 179.4056805 -0.84918417 0.000500269 0.004464115 RNASEH2A ENSG00000104889 552.8836647 -0.675688469 0.000501283 0.00446992 BAD ENSG00000002330 1082.341632 -0.537154015 0.000503445 0.004485967 CCDC121 ENSG00000176714 60.48602365 -1.140140832 0.00050576 0.004503341 PLAUR ENSG00000011422 7496.298158 0.840429498 0.000506499 0.004506669 ZBTB42 ENSG00000179627 215.7986075 -0.994242455 0.000506488 0.004506669 TCEA2 ENSG00000171703 761.8557935 -0.524658831 0.000507591 0.004514761 TMIGD2 ENSG00000167664 759.916833 -0.75297576 0.00050903 0.004522677 SNX20 ENSG00000167208 6720.283172 -0.526982678 0.000510358 0.004532844 CD79B ENSG00000007312 2244.055174 -0.827334951 0.000510658 0.004533876 CD84 ENSG00000066294 10256.20883 0.5717761 0.000515317 0.004567037 RNF115 ENSG00000265491 6524.149418 0.581615943 0.00051599 0.004571359 SELENOP ENSG00000250722 158.0234771 1.023312162 0.000518582 0.004586198 B3GALT2 ENSG00000162630 37.49057718 -1.556472874 0.000519417 0.004586198 RELL2 ENSG00000164620 1305.655557 -0.572855664 0.000518836 0.004586198 DOLK ENSG00000175283 272.3481532 -0.726428644 0.000518725 0.004586198 PEX6 ENSG00000124587 1754.308798 -0.626722279 0.000519251 0.004586198 PPFIA1 ENSG00000131626 5004.02178 0.46577108 0.000519827 0.004587251 CNOT2 ENSG00000111596 5169.471672 0.526963082 0.000521518 0.004600536 ALOX5 ENSG00000012779 24110.78454 0.672085796 0.000522789 0.004610097

IFT20 ENSG00000109083 2146.29125 0.419451687 0.000523657 0.004614458 NT5C ENSG00000125458 1364.771417 -0.525345153 0.000524275 0.004618259 RTN4 ENSG00000115310 15654.24467 0.480483471 0.00052539 0.004626428 ASB6 ENSG00000148331 3230.588489 -0.503896553 0.000526692 0.00463624 SLC35C1 ENSG00000181830 1283.095981 -0.614086357 0.000526912 0.004636524 OLFM4 ENSG00000102837 3332.041083 1.674252509 0.000527497 0.004640019 CD164 ENSG00000135535 19097.63731 0.458614553 0.000528594 0.004648014 WDR54 ENSG00000005448 572.0354498 -0.705429913 0.000529333 0.004652855 SAV1 ENSG00000151748 60.04359359 0.977245065 0.000530255 0.004657649 HIST2H4B ENSG00000270276 243.0911646 -0.672106828 0.000530458 0.004657771 TAP1 ENSG00000168394 15639.61228 -0.528082088 0.000533588 0.004678601 GSDMD ENSG00000104518 5332.098868 -0.470286443 0.000538231 0.004709279 FCGR1A ENSG00000150337 2396.943616 0.83024791 0.000539545 0.00471911 ELK4 ENSG00000158711 8519.519658 0.496656615 0.000542399 0.004740716 TAF13 ENSG00000197780 934.4455044 0.692765118 0.00054373 0.004749192 ASB2 ENSG00000100628 289.5940053 -0.87296155 0.000543754 0.004749192 P4HA2 ENSG00000072682 62.91405852 1.151564311 0.000544585 0.004753294 GABARAPL1 ENSG00000139112 3919.427637 0.929684745 0.000547003 0.004769143 GDAP2 ENSG00000196505 2772.826678 0.537322346 0.000547281 0.004769882 NDUFAF3 ENSG00000178057 1336.932446 -0.404036738 0.000548887 0.0047805 ZER1 ENSG00000160445 3768.284273 -0.416923453 0.00054909 0.00478059 HAX1 ENSG00000143575 2881.852579 -0.420643736 0.000552699 0.004808618 CEACAM8 ENSG00000124469 2351.583671 1.534462448 0.000558164 0.00485104 HIGD2A ENSG00000146066 6424.57059 -0.404580687 0.000568798 0.004934775 ATG9B ENSG00000181652 308.7517652 -0.913591235 0.000570205 0.00493831 MRPL41 ENSG00000182154 2073.304624 -0.621183832 0.000571918 0.004949672 CD2AP ENSG00000198087 3021.24792 0.42986188 0.000578055 0.004995784 PIKFYVE ENSG00000115020 10333.09434 0.430886936 0.000579742 0.005005719 AKR1B1 ENSG00000085662 3525.161145 -0.452018478 0.000582831 0.005021457 FTSJ1 ENSG00000068438 2542.649173 -0.297443472 0.000582855 0.005021457 MANEAL ENSG00000185090 102.1352312 -0.824118772 0.000584896 0.00503553 MOGS ENSG00000115275 4169.285681 -0.41661733 0.000585191 0.005036313 PIDD1 ENSG00000177595 2014.405784 -0.562232581 0.000585567 0.005037797 C14orf1 ENSG00000133935 822.9554408 -0.837479794 0.000591582 0.005087768 IQGAP2 ENSG00000145703 17713.05089 0.52559642 0.000593306 0.005100821 ITPA ENSG00000125877 2703.513785 -0.434671655 0.000595236 0.005113856 LETM1 ENSG00000168924 2901.72011 -0.340951047 0.000595119 0.005113856 SPAG1 ENSG00000104450 562.9188022 0.612886094 0.000595803 0.005116944 EDF1 ENSG00000107223 11943.98368 -0.412586566 0.000598284 0.0051329 CD1E ENSG00000158488 66.65735629 -1.058352988 0.000602383 0.005160876 CPVL ENSG00000106066 29937.54269 0.635538537 0.000603691 0.005165687 LSM4 ENSG00000130520 3073.11611 -0.638997701 0.000603567 0.005165687 C19orf73 ENSG00000221916 31.22909921 -1.128274213 0.000604904 0.005173518 SRSF11 ENSG00000116754 21761.23565 0.436786582 0.000606785 0.005184222 TTC30B ENSG00000196659 135.5298869 -0.697683802 0.000609685 0.005203597 FAM49A ENSG00000197872 10509.73306 0.648430463 0.000611823 0.005220045

HNRNPA3 ENSG00000170144 34178.40383 0.302326565 0.000612643 0.005225233 PLAC8 ENSG00000145287 17884.79325 0.727938145 0.00061431 0.005234034 MBLAC2 ENSG00000176055 578.8154561 -0.524749408 0.00061717 0.00525426 RAP2C ENSG00000123728 6507.606312 0.573844271 0.000618314 0.005260884 POP5 ENSG00000167272 1314.012583 -0.484666904 0.000623568 0.005296467 ADA ENSG00000196839 2049.923197 -0.64221758 0.000623935 0.005297116 DNAAF5 ENSG00000164818 944.2591185 -0.524863926 0.000624073 0.005297116 OMG ENSG00000126861 397.543793 0.625970421 0.000624972 0.005302921 MRPL55 ENSG00000162910 916.6571964 -0.53686786 0.000628472 0.005328955 ARHGEF1 ENSG00000076928 53028.49633 -0.399236712 0.000629961 0.005339751 FBXO11 ENSG00000138081 6766.002658 0.428554524 0.000630417 0.005339953 SGCB ENSG00000163069 363.287797 -0.607405512 0.000630829 0.005341613 PRKAG2 ENSG00000106617 5970.811775 0.498536341 0.000632828 0.00535663 LPO ENSG00000167419 31.93657049 1.654532099 0.000633037 0.00535663 SOX6 ENSG00000110693 29.00416328 0.989554996 0.000633497 0.005358689 ERG ENSG00000157554 254.3317139 1.570284444 0.000635605 0.005372842 RARRES3 ENSG00000133321 4985.980639 -0.726763206 0.000635905 0.005373538 ITPRIPL1 ENSG00000198885 820.8848361 -0.877017324 0.000637679 0.005386687 FAM109A ENSG00000198324 828.1178498 -0.734670474 0.000641322 0.005411909 KMT2E ENSG00000005483 16814.69784 0.508710619 0.000642618 0.005419142 RNF144A ENSG00000151692 1611.055598 -0.66395425 0.000645179 0.005437024 SEMA4A ENSG00000196189 9493.611413 0.542238548 0.000646434 0.005445748 WRAP73 ENSG00000116213 2282.484246 -0.360021869 0.000646689 0.005446032 CD40LG ENSG00000102245 1526.190965 -0.846895093 0.000648202 0.005455052 IFT22 ENSG00000128581 116.0233578 -0.72763121 0.000651328 0.005473044 SENP5 ENSG00000119231 2126.914921 0.758351462 0.000650869 0.005473044 KBTBD3 ENSG00000182359 284.6514332 -0.526972532 0.000651065 0.005473044 MAP4K4 ENSG00000071054 17591.93787 0.424906289 0.000651456 0.005473044 AHCTF1 ENSG00000153207 4721.50356 0.572193011 0.000654001 0.005490765 EVA1B ENSG00000142694 400.6086745 -0.82203864 0.000655398 0.005500624 SPET10 ENSG00000186522 455.3170531 0.823474083 0.000656731 0.005509933 TECR ENSG00000099797 2919.220866 -0.405893002 0.00065723 0.005512251 DCP1B ENSG00000151065 1393.944087 -0.541562067 0.000662961 0.005552777 DCTPP1 ENSG00000179958 653.9064689 -0.734014299 0.000664794 0.005563906 ELANE ENSG00000197561 855.6858189 1.529749501 0.000665862 0.005565981 WDR18 ENSG00000065268 1001.372436 -0.609702389 0.00066589 0.005565981 HTRA1 ENSG00000166033 241.0880042 1.28828987 0.000667057 0.005573848 TLE2 ENSG00000065717 436.7507927 -0.937807107 0.000669172 0.005587747 UBE4B ENSG00000130939 4145.660652 0.367341234 0.000669913 0.005592039 ZMYM4 ENSG00000146463 4156.239576 0.347937798 0.000670465 0.005592932 SMARCD3 ENSG00000082014 5243.344212 0.548527793 0.000671576 0.005596468 GBA2 ENSG00000070610 7452.177194 -0.23767441 0.000671489 0.005596468 CLASP2 ENSG00000163539 4179.055367 0.48367298 0.000673268 0.005608675 PLD1 ENSG00000075651 854.0504388 0.918882551 0.000675867 0.005624634 PHF3 ENSG00000118482 9027.30963 0.630915788 0.000676635 0.005629133 SESN3 ENSG00000149212 8804.053638 0.573402198 0.000677279 0.005632593

PRDM10 ENSG00000170325 1409.721443 0.478352898 0.000678087 0.005635859 PDZD11 ENSG00000120509 734.8546666 -0.512276334 0.000678129 0.005635859 VIT ENSG00000205221 55.07474572 -1.504854514 0.00067882 0.005639705 MBNL1 ENSG00000152601 48379.50911 0.382527659 0.000684135 0.005681956 PRR3 ENSG00000204576 1015.948382 -0.407478718 0.00068616 0.005694943 SPTAN1 ENSG00000197694 17470.99366 -0.376274384 0.000686619 0.00569684 CD44 ENSG00000026508 48007.14329 0.470308731 0.000687103 0.005697024 SLAIN1 ENSG00000139737 971.7348923 -0.483980686 0.000687585 0.005699109 RTN3 ENSG00000133318 15495.17877 0.751053613 0.000689677 0.005712614 PSMC1 ENSG00000100764 6447.929494 0.354737245 0.00069199 0.005724097 ZNF185 ENSG00000147394 5174.082388 0.556268647 0.00069269 0.005727967 ATL2 ENSG00000119787 2962.23522 0.539969917 0.000693378 0.005731743 POLR2L ENSG00000177700 2281.875205 -0.5938284 0.000695524 0.005743712 TCTN2 ENSG00000168778 312.6284381 -0.738339013 0.0006961 0.005746551 TMEM99 ENSG00000167920 110.3119666 -0.995536428 0.000704754 0.005806349 KIAA0196 ENSG00000164961 5270.524098 0.395017129 0.000705359 0.005809389 ITPRIP ENSG00000148841 9782.484717 0.849360329 0.000706935 0.005820429 MARCH1 ENSG00000186205 3656.696446 0.91955455 0.000709366 0.005836559 GPR34 ENSG00000171659 568.529857 1.281117766 0.000712594 0.00585921 RB1CC1 ENSG00000023287 5586.778311 0.665609172 0.000714025 0.005869027 FAR2 ENSG00000064763 1695.999383 0.835230819 0.000717162 0.005892848 SAC3D1 ENSG00000168061 236.0924373 -0.849540592 0.000721215 0.00591858 CDAN1 ENSG00000140326 1645.86037 -0.430658964 0.000722976 0.005930756 TMEM101 ENSG00000091947 1158.652926 -0.517905068 0.000724193 0.005936794 MT1E ENSG00000169715 212.1876052 1.101087812 0.000726872 0.005956784 LAX1 ENSG00000122188 1370.333164 -0.828063123 0.000727248 0.005957885 NFIA ENSG00000162599 486.1600592 1.13632521 0.000728509 0.005964258 PHGDH ENSG00000092621 255.9574237 -0.944012691 0.000729942 0.005971694 ERAL1 ENSG00000132591 1823.887223 -0.548871786 0.000730142 0.005971694 TIGD2 ENSG00000180346 327.4028106 -0.547518585 0.000731242 0.00597683 ZFYVE28 ENSG00000159733 2697.859398 -0.75703182 0.000731254 0.00597683 CD46 ENSG00000117335 9896.674303 0.534055622 0.000731921 0.005978225 DZIP1L ENSG00000158163 171.6802701 1.114225046 0.000732151 0.005978225 ZNF732 ENSG00000186777 13.10477451 -1.449855931 0.000732698 0.005980714 NR4A2 ENSG00000153234 4197.34756 1.040135755 0.00073337 0.005984222 PSAP ENSG00000197746 283915.1411 0.505906707 0.000735094 0.005992203 RAE1 ENSG00000101146 3471.901381 0.355694906 0.000735319 0.005992203 USP38 ENSG00000170185 4200.326648 0.387270439 0.000736473 0.00599568 ZNF326 ENSG00000162664 3973.581225 0.601898447 0.000742794 0.006039173 SRSF7 ENSG00000115875 14287.03366 -0.405478757 0.000743579 0.006041578 HDDC2 ENSG00000111906 2364.613614 -0.493388839 0.000751048 0.006092243 HAPLN3 ENSG00000140511 2307.009874 -0.783698384 0.000755818 0.006126915 TTC9C ENSG00000162222 1269.482681 -0.598836 0.000756625 0.006131439 ARIH2OS ENSG00000221883 259.664019 -0.623571029 0.000757352 0.00613532 SETD2 ENSG00000181555 12278.81963 0.356158882 0.000758676 0.006140083 CD1D ENSG00000158473 7367.665219 0.62706196 0.000758686 0.006140083

EXOSC5 ENSG00000077348 820.1189071 -0.459986143 0.000760875 0.006153766 CCDC188 ENSG00000234409 287.2902065 -0.661908046 0.000761477 0.00615662 CTIF ENSG00000134030 1369.567968 0.67991223 0.00076203 0.006159081 SCRG1 ENSG00000164106 41.67044682 1.314454937 0.000765045 0.006181425 CELSR2 ENSG00000143126 666.4898144 -0.589230966 0.000768398 0.006206486 ANOS1 ENSG00000011201 33.61968205 1.40234354 0.000769517 0.006211463 KIF27 ENSG00000165115 791.4980549 0.898336741 0.000769444 0.006211463 CTD-2267D19.3 ENSG00000266208 182.8618022 0.633556897 0.000772251 0.006227422 PROS1 ENSG00000184500 220.3570424 1.03422517 0.000775638 0.006246579 DUSP23 ENSG00000158716 883.2627682 -0.610032541 0.000777295 0.006257883 CFD ENSG00000197766 4414.195816 -0.72668512 0.000779086 0.006268219 PLB1 ENSG00000163803 2627.312446 0.706396775 0.000782415 0.006290902 AMPH ENSG00000078053 341.3600999 1.563539465 0.000785887 0.006316763 PDCD11 ENSG00000148843 3219.058008 -0.312101999 0.000787715 0.006329396 PPP1R13B ENSG00000088808 1125.561336 -0.533679139 0.000789945 0.006345253 SDCBP ENSG00000137575 18512.372 0.776745469 0.000790309 0.006346109 SUPV3L1 ENSG00000156502 2838.700556 0.681252542 0.00079215 0.006354691 RTCA ENSG00000137996 3614.211818 0.406742812 0.000793771 0.006365634 ICA1 ENSG00000003147 532.8621325 0.821534568 0.000794948 0.006371136 CA14 ENSG00000118298 145.5722416 0.6962952 0.000795948 0.006376882 COQ6 ENSG00000119723 1225.180337 -0.389212842 0.000799971 0.006402875 SRGAP2 ENSG00000266028 7183.532162 0.581366264 0.000804706 0.006434519 ATG7 ENSG00000197548 3969.058341 0.533880784 0.000807584 0.006455442 PKN3 ENSG00000160447 281.8302351 -0.774029717 0.000808707 0.00646233 PLOD3 ENSG00000106397 2865.000307 -0.382634898 0.000811301 0.00647677 PDGFD ENSG00000170962 816.1398365 -0.983527019 0.000811135 0.00647677 ID3 ENSG00000117318 224.0333772 -1.105538095 0.000810948 0.00647677 ARSK ENSG00000164291 324.9592433 -0.677462297 0.00081233 0.006478702 KLHL24 ENSG00000114796 4203.965059 1.013713101 0.000811949 0.006478702 GCN1 ENSG00000089154 8981.083735 -0.365328174 0.000812261 0.006478702 SIPA1L2 ENSG00000116991 1579.644018 0.906799174 0.000817561 0.006514112 TMEM259 ENSG00000182087 10093.77657 -0.550682882 0.000818323 0.006518087 CREB3L4 ENSG00000143578 445.1692513 -0.452427735 0.000819325 0.006523964 ISCA1 ENSG00000135070 4909.505514 0.572486898 0.000825535 0.006567054 C19orf44 ENSG00000105072 350.2380026 -0.457114675 0.000826439 0.00657002 BNIPL ENSG00000163141 90.68293249 -1.139583235 0.000829087 0.006588948 PNPLA4 ENSG00000006757 413.6136291 -0.525630336 0.000829905 0.006591209 RFNG ENSG00000169733 1500.705518 -0.423983034 0.000830906 0.006594913 MAT2B ENSG00000038274 7946.446711 -0.470051654 0.000830879 0.006594913 ZFYVE21 ENSG00000100711 973.1530019 -0.464388662 0.00083239 0.006604571 PLBD2 ENSG00000151176 3754.985556 0.54078502 0.000839805 0.006659131 RAB15 ENSG00000139998 569.5532663 -0.662426981 0.000840269 0.006660665 HS3ST3A1 ENSG00000153976 68.79162856 -1.011390161 0.000846641 0.006696138 TTLL1 ENSG00000100271 475.4236986 -0.520957361 0.000845405 0.006696138 CD81 ENSG00000110651 6382.689464 -0.629614668 0.000850157 0.006719644 STAG2 ENSG00000101972 9689.471323 0.577869812 0.000856018 0.006753004

FBXO7 ENSG00000100225 14864.8868 0.450879201 0.000861735 0.006791596 WDFY2 ENSG00000139668 4196.047509 0.514178133 0.000869318 0.006840443 EML2 ENSG00000125746 3260.592372 -0.437141432 0.000870663 0.006848847 OSCAR ENSG00000170909 5897.547707 0.706823581 0.000873864 0.006870245 YPEL3 ENSG00000090238 6955.298602 -0.551587924 0.00087394 0.006870245 DCP1A ENSG00000272886 3390.64429 0.530636291 0.000875711 0.006881976 FAM13B ENSG00000031003 5274.067813 0.427825293 0.000876599 0.00688677 STEAP1B ENSG00000105889 14.60228774 1.575503024 0.000877721 0.00689177 NAT9 ENSG00000109065 2026.974972 -0.391460189 0.00087954 0.00690109 NCOA2 ENSG00000140396 6721.378476 0.650254136 0.000884812 0.006935844 ZNF561 ENSG00000171469 1542.576755 -0.410392385 0.000885717 0.00693854 SEC62 ENSG00000008952 6362.296666 0.596585979 0.000886785 0.006944702 MITD1 ENSG00000158411 2425.535598 -0.442250161 0.000890676 0.0069657 CTSB ENSG00000164733 49109.23999 0.761785907 0.000891337 0.0069657 FBXL3 ENSG00000005812 5795.075349 0.726896119 0.000894961 0.006988785 ZAP70 ENSG00000115085 21116.89466 -0.823307836 0.000895971 0.006994462 ZNF568 ENSG00000198453 472.2911792 -0.568964367 0.000900351 0.007019781 CKAP2 ENSG00000136108 1859.00685 0.53652069 0.000901445 0.00702388 ATP6V0E2 ENSG00000171130 1448.001907 -0.749549067 0.000901161 0.00702388 OSMR ENSG00000145623 90.35763834 0.962153873 0.000901809 0.007024497 SLC7A6OS ENSG00000103061 1327.885774 -0.435162512 0.000902426 0.007027091 LMOD2 ENSG00000170807 36.77072476 1.457115474 0.000906137 0.007053762 ACOT7 ENSG00000097021 588.252331 -0.737421363 0.000908619 0.007070851 ITSN1 ENSG00000205726 1222.346458 0.732044958 0.000910191 0.0070764 IL4 ENSG00000113520 19.12233421 -1.606011712 0.000911836 0.00708473 KLHL9 ENSG00000198642 2476.294797 -0.393255099 0.00091341 0.007094723 PSTPIP2 ENSG00000152229 7218.208827 0.631632201 0.000914346 0.007099759 SPTY2D1 ENSG00000179119 3349.178977 0.543072017 0.000920748 0.007142737 IRF7 ENSG00000185507 4200.445655 -0.804292057 0.000921467 0.007146068 UNG ENSG00000076248 822.4434889 -0.670531808 0.000922992 0.007155651 FAM213B ENSG00000157870 864.2227537 -0.891039982 0.000925272 0.007165836 FAM131B ENSG00000159784 243.0593489 -0.999624532 0.000924686 0.007165836 IL1R2 ENSG00000115590 5314.939797 1.621687484 0.000925466 0.007165836 PHF21A ENSG00000135365 11379.95483 0.449467775 0.000925759 0.007165857 RPGR ENSG00000156313 1817.09426 0.469033686 0.000926329 0.007168022 CD3D ENSG00000167286 6675.669943 -0.863276638 0.000927914 0.007173545 SLC8A1 ENSG00000183023 3273.646237 0.741213946 0.000928873 0.00717871 SLC37A4 ENSG00000137700 686.9690277 -0.436593114 0.000932951 0.007201217 BAG5 ENSG00000166170 4247.092738 0.388624539 0.000943929 0.007279129 ABHD2 ENSG00000140526 12744.31108 0.837363501 0.00094804 0.007308549 KPNA1 ENSG00000114030 7464.077674 0.306879097 0.000952737 0.007335603 USP16 ENSG00000156256 6957.543037 0.443152334 0.000953591 0.007339888 PIGB ENSG00000069943 2220.269637 0.392636948 0.000954021 0.007340909 SPAG17 ENSG00000155761 28.29762729 1.420790993 0.000954581 0.00734293 ZNF175 ENSG00000105497 742.127384 -0.780875249 0.000958498 0.00736847 MAFF ENSG00000185022 2397.453678 1.125156114 0.000960031 0.007375669

ELOF1 ENSG00000130165 2539.52587 -0.40928693 0.000959801 0.007375669 ANXA1 ENSG00000135046 63347.07769 0.624348221 0.000964071 0.007397503 YWHAZ ENSG00000164924 63603.21857 0.327950949 0.000966319 0.007412449 MBOAT2 ENSG00000143797 1395.272753 0.952813186 0.000967064 0.007413554 PARP3 ENSG00000041880 1008.104484 -0.392496426 0.000970798 0.007437566 RILPL2 ENSG00000150977 8073.806756 0.646661078 0.000970594 0.007437566 PRPF40A ENSG00000196504 8798.997878 0.500221275 0.000974845 0.007457005 OBSL1 ENSG00000124006 55.73584855 -0.89997772 0.000975439 0.007459243 VPS28 ENSG00000160948 6971.879314 -0.449342665 0.000978736 0.007477503 HIST1H4H ENSG00000158406 280.8062247 0.542486481 0.000980858 0.0074914 CBWD5 ENSG00000147996 2269.115245 0.376351098 0.000981605 0.007492475 DAP ENSG00000112977 6912.259632 0.330424675 0.000986125 0.007517681 MFSD10 ENSG00000109736 3899.697546 -0.568882335 0.000991009 0.007545595 TXLNA ENSG00000084652 3861.754148 -0.494687261 0.000997468 0.007587763 SCYL2 ENSG00000136021 6026.749662 0.383593659 0.001000614 0.00760701 C1orf198 ENSG00000119280 317.3375132 -0.501239767 0.001002308 0.007615199 PIK3CB ENSG00000051382 2646.259907 0.498213174 0.00100382 0.007621999 METTL21A ENSG00000144401 718.0084921 -0.395132797 0.001014004 0.007692232 RRP1 ENSG00000160214 1419.256296 -0.453581736 0.00101585 0.007699138 PELP1 ENSG00000141456 3468.769827 -0.428844383 0.00101581 0.007699138 NMT2 ENSG00000152465 1369.762237 -0.721536131 0.001020292 0.007725692 THAP4 ENSG00000176946 2254.838866 -0.377694923 0.001023779 0.00774972 KCTD21 ENSG00000188997 633.8502855 -0.834784027 0.001025332 0.007756726 EPS8L2 ENSG00000177106 198.4957688 -0.947837899 0.001029045 0.007780047 NSUN3 ENSG00000178694 1713.693618 0.595531038 0.001030183 0.007786265 DGCR6 ENSG00000183628 137.8123981 -0.827793839 0.001031811 0.00779392 BCL2A1 ENSG00000140379 9698.718556 0.948183758 0.001035098 0.007812632 ITGB7 ENSG00000139626 10597.70494 -0.665753434 0.001035569 0.007812632 WDR34 ENSG00000119333 514.2799645 -0.751790319 0.001036953 0.007819719 NAP1L3 ENSG00000186310 196.1085651 -0.813061756 0.001037142 0.007819719 GMFB ENSG00000197045 3969.70976 0.745533356 0.001040293 0.007833911 FBLN2 ENSG00000163520 198.5334722 -1.111884516 0.001040798 0.007835327 EREG ENSG00000124882 660.3978048 1.420081692 0.00104238 0.007840589 NOL10 ENSG00000115761 1812.482222 0.328290633 0.001041844 0.007840589 APBB2 ENSG00000163697 127.7117137 1.053962847 0.001044148 0.007843816 CNKSR1 ENSG00000142675 233.0528536 -0.730806327 0.001046032 0.007855579 NOC2L ENSG00000188976 6056.013675 -0.295898579 0.001048405 0.00786861 C2CD4D ENSG00000225556 35.26690773 -1.274542146 0.001049439 0.007873978 PHKB ENSG00000102893 7081.695655 0.389384252 0.001051438 0.007886584 TAS2R50 ENSG00000212126 14.8534539 1.222317572 0.001058318 0.007930966 PFKM ENSG00000152556 751.257689 -0.43612266 0.00107061 0.008012781 RAB11FIP2 ENSG00000107560 1825.398576 0.514061835 0.001070858 0.008012781 EPS15 ENSG00000085832 11302.40078 0.321729899 0.001071933 0.0080184 PSMD12 ENSG00000197170 3421.38557 0.445002946 0.00107488 0.008037983 AC243756.1 ENSG00000270339 22.21713284 -1.342370294 0.001075202 0.008037983 CITED2 ENSG00000164442 5536.346916 -0.503072679 0.001077864 0.008055443

HDAC11 ENSG00000163517 352.4508098 -0.547842837 0.001079117 0.008062368 IDO1 ENSG00000131203 66.37263083 -1.348490284 0.001082377 0.008081834 ORMDL1 ENSG00000128699 9594.81527 0.273459856 0.001085654 0.008101982 SAP30 ENSG00000164105 3428.603556 1.090979977 0.001086374 0.008101982 GOLGB1 ENSG00000173230 8028.593368 0.368744526 0.001086873 0.00810316 U2AF2 ENSG00000063244 13445.653 -0.304852921 0.001087829 0.00810784 ELL2 ENSG00000118985 4019.862204 0.930141856 0.001089687 0.008114342 FASLG ENSG00000117560 522.6360785 -1.163161176 0.001094052 0.008141933 TCF3 ENSG00000071564 3446.690158 -0.596332019 0.001099251 0.00817816 ACPP ENSG00000014257 3194.281916 0.728470392 0.00109974 0.008179335 KCNE1 ENSG00000180509 1544.445691 0.97855579 0.001112913 0.00826673 LRRC8A ENSG00000136802 2586.10312 -0.490254096 0.001121656 0.008322287 ADRA2A ENSG00000150594 14.55508366 -1.468471009 0.001136665 0.008413432 GNB4 ENSG00000114450 4798.283396 0.73044435 0.001138118 0.008415064 UACA ENSG00000137831 816.5065471 0.963615595 0.001137774 0.008415064 TXNDC2 ENSG00000168454 22.52621268 1.419652783 0.001139855 0.008420958 F2RL3 ENSG00000127533 56.51754259 -1.048921282 0.001143794 0.008443431 CCDC22 ENSG00000101997 2616.464283 -0.327103918 0.00115204 0.008484014 SLC39A13 ENSG00000165915 2039.619417 -0.694677205 0.001154688 0.008498902 ATP1A3 ENSG00000105409 696.8554863 -0.809990754 0.001158017 0.008520413 FCRLB ENSG00000162746 143.0789252 -1.121722231 0.001173318 0.008620153 SLC7A7 ENSG00000155465 13928.01889 0.593815512 0.001181445 0.008664399 NPTXR ENSG00000221890 546.4970702 -0.855683404 0.001182414 0.00866893 NOP16 ENSG00000048162 801.2170117 -0.487149847 0.001187162 0.008695996 TAOK3 ENSG00000135090 12409.92676 0.363647871 0.001186928 0.008695996 PMM1 ENSG00000100417 1324.337901 -0.443444659 0.00120152 0.008792827 HTR1F ENSG00000179097 32.19155263 1.372972781 0.001203548 0.008802971 NDUFAF4 ENSG00000123545 495.1272 -0.668956154 0.001211051 0.008844756 GNAZ ENSG00000128266 342.9827534 -0.905542037 0.001210972 0.008844756 RICTOR ENSG00000164327 10555.19167 0.526567617 0.001213494 0.008857358 LIMD2 ENSG00000136490 19236.06413 -0.489721549 0.00121723 0.008879377 BMP6 ENSG00000153162 226.3998211 -0.738492874 0.001224353 0.008923436 SLC16A13 ENSG00000174327 176.2208912 -1.034831698 0.001224316 0.008923436 UBXN2B ENSG00000215114 6905.183706 0.536286647 0.001224999 0.008925506 HENMT1 ENSG00000162639 1565.741049 -0.432165123 0.00122987 0.008958355 FBXO44 ENSG00000132879 2218.808445 -0.529161286 0.001236347 0.009002877 ADRB1 ENSG00000043591 52.72542695 -1.207740832 0.001238116 0.009013102 JAKMIP2 ENSG00000176049 595.948272 -0.915178375 0.001239411 0.009016825 WDR86 ENSG00000187260 498.2852009 -0.663865445 0.001245294 0.009052021 CHST11 ENSG00000171310 8191.445274 0.416854246 0.001247647 0.009063788 FAM208B ENSG00000108021 5587.777359 0.420527429 0.001248089 0.009064333 RYR1 ENSG00000196218 340.6881396 -0.654701745 0.00125739 0.009123833 LAMTOR5 ENSG00000134248 3302.082407 0.44645307 0.001258217 0.009127155 GCDH ENSG00000105607 1351.628345 -0.376780371 0.001261203 0.009146126 PPP2R5D ENSG00000112640 3708.385137 -0.286132064 0.001269533 0.009198432 CST7 ENSG00000077984 13515.64993 -0.817405871 0.001272245 0.009215385

BCL9L ENSG00000186174 13825.24582 -0.594436212 0.001277175 0.009240249 C19orf68 ENSG00000185453 592.1658743 -0.773727666 0.001279357 0.009253329 RNF7 ENSG00000114125 2188.702903 0.559304352 0.001281362 0.009265121 ERO1B ENSG00000086619 2251.327764 0.479739102 0.001283092 0.009274913 TRIM38 ENSG00000112343 9514.733806 0.668083969 0.001286578 0.009294673 CD274 ENSG00000120217 422.7103248 -0.622589168 0.001293852 0.009341753 ZNF281 ENSG00000162702 4282.789739 0.842236754 0.001294489 0.009343624 FAM21C ENSG00000172661 14629.7657 0.360510457 0.001302479 0.009393059 SLC4A3 ENSG00000114923 109.608369 -1.387317379 0.001303106 0.009393779 COQ8A ENSG00000163050 4185.784845 -0.366720006 0.00130448 0.009393779 ZNF790 ENSG00000197863 189.8268718 -0.525648615 0.001303369 0.009393779 ZNF234 ENSG00000263002 598.790033 -0.688256906 0.001305536 0.009394379 CA1 ENSG00000133742 411.0607474 1.548025259 0.001305095 0.009394379 USP43 ENSG00000154914 85.09479131 -0.994960631 0.00130898 0.009415199 C1orf123 ENSG00000162384 1627.40593 -0.395456841 0.001313918 0.009439728 NAMPTP1 ENSG00000229644 6167.382258 1.316299079 0.001316322 0.009448755 OLR1 ENSG00000173391 286.4336129 1.36881379 0.001316139 0.009448755 C3orf52 ENSG00000114529 172.5627716 -0.769785372 0.001321842 0.009477359 FAM13A ENSG00000138640 4390.672404 0.819420156 0.001323191 0.009484279 LMAN2L ENSG00000114988 597.2017414 -0.579824165 0.00132482 0.009493198 PDZD4 ENSG00000067840 2511.811013 -1.011345699 0.001326108 0.009494475 PPP1R2 ENSG00000184203 9744.171272 0.36673189 0.001326151 0.009494475 EXOSC8 ENSG00000120699 2184.443047 -0.413734557 0.00132936 0.009514687 HECA ENSG00000112406 16198.95393 0.481332089 0.00133099 0.009520837 RPH3A ENSG00000089169 918.1506563 1.195347298 0.001330905 0.009520837 RASGRP2 ENSG00000068831 27808.30234 -0.435844186 0.001331452 0.009521382 C1orf109 ENSG00000116922 671.8059385 -0.443968388 0.001334147 0.009531948 HIST1H2AG ENSG00000196787 124.4324829 -0.919044304 0.001333342 0.009531948 ANKRD50 ENSG00000151458 1864.248111 0.735525231 0.001336624 0.009544555 SERPINA1 ENSG00000197249 58690.57957 0.600969312 0.001339267 0.009555139 ZFP92 ENSG00000189420 515.8054187 0.863225323 0.001346409 0.009597777 MASP2 ENSG00000009724 4145.65759 0.469226008 0.00134711 0.009598212 CCDC59 ENSG00000133773 3725.819082 0.352266912 0.001347247 0.009598212 WDTC1 ENSG00000142784 8353.515386 -0.280502192 0.00134871 0.009603096 FKBP6 ENSG00000077800 42.12079473 0.847084447 0.001349593 0.009606616 HAGHL ENSG00000103253 475.7471728 -0.696772795 0.001351868 0.009620031 GPR157 ENSG00000180758 306.1893115 -0.637049085 0.001353739 0.009630575 PTGFR ENSG00000122420 59.82834525 1.52885969 0.001378221 0.009773778 MAN2A1 ENSG00000112893 9485.953875 0.398879728 0.001386761 0.009820237 CKS1BP3 ENSG00000268942 20.8676895 -0.984825708 0.001390834 0.009843438 EIF3E ENSG00000104408 31658.81227 0.226084957 0.001394203 0.009857343 TRIM35 ENSG00000104228 1813.739904 -0.565440347 0.001395405 0.009858839 NDUFAF8 ENSG00000224877 635.8173894 -0.698375951 0.001398765 0.009879755 ROBO3 ENSG00000154134 468.3368819 -0.700829342 0.001403065 0.009904458 CACNG6 ENSG00000130433 60.89084595 -1.392837966 0.001402709 0.009904458 SCAMP3 ENSG00000116521 2477.85022 -0.348693869 0.001405348 0.009915173

GP9 ENSG00000169704 337.4322047 -0.93996845 0.001405385 0.009915173 MARS2 ENSG00000247626 610.8587187 -0.51794797 0.001408713 0.009935811 SLC39A9 ENSG00000029364 1700.209521 1.002538464 0.001413841 0.009963442 INTS12 ENSG00000138785 1656.914355 0.311816487 0.001414869 0.009965003 PARS2 ENSG00000162396 92.59241011 -1.183617471 0.001416114 0.00996869 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 7. Significantly differential expressed genes in the comparison of ACLF with CHB

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (ACLF/CHB) adjustedb

SEMA6B ENSG00000167680 7330.655631 3.77514397 3.04E-23 5.54E-19 PPARG ENSG00000132170 232.6880582 2.523662086 1.71E-18 1.56E-14 THBD ENSG00000178726 2582.607367 2.516113305 1.71E-17 1.04E-13 MERTK ENSG00000153208 2629.507564 1.946242182 4.74E-16 2.16E-12 ADM ENSG00000148926 3028.024778 2.255523922 1.24E-14 4.54E-11 ACOX2 ENSG00000168306 71.68505065 2.070715719 8.43E-13 2.32E-09 MAFB ENSG00000204103 17713.76829 1.788292088 2.25E-12 5.14E-09 TCN2 ENSG00000185339 3251.502002 1.828791176 3.36E-11 6.80E-08 SYN1 ENSG00000008056 168.0570247 2.208673459 3.87E-11 7.06E-08 PDK4 ENSG00000004799 5195.380298 1.787842341 8.10E-11 1.34E-07 TNFAIP6 ENSG00000123610 447.7599864 1.990355716 2.07E-10 2.90E-07 ST14 ENSG00000149418 5112.358165 1.379542441 2.31E-10 3.01E-07 CTD-2267D19.3 ENSG00000266208 158.2191142 1.041705113 2.61E-10 3.09E-07 SOCS3 ENSG00000184557 11517.49491 1.705578219 2.94E-10 3.09E-07 PGD ENSG00000142657 32151.79005 1.111416217 2.88E-10 3.09E-07 THBS1 ENSG00000137801 63293.43566 2.517206881 3.22E-10 3.09E-07 S100A12 ENSG00000163221 23250.54695 1.744730521 4.87E-10 4.28E-07 IL10 ENSG00000136634 314.0800537 2.452302207 4.93E-10 4.28E-07 ETS2 ENSG00000157557 15000.058 1.66253341 7.03E-10 5.83E-07 GPER1 ENSG00000164850 408.2098052 1.855050618 1.12E-09 8.20E-07 GYG1 ENSG00000163754 5490.457087 0.972368286 1.12E-09 8.20E-07 FAM20A ENSG00000108950 818.3014719 2.28337043 1.12E-09 8.20E-07 RNF144B ENSG00000137393 12466.57827 1.465927721 1.42E-09 9.94E-07 C1orf43 ENSG00000143612 5718.771897 0.551422291 1.70E-09 1.15E-06 TDRD9 ENSG00000156414 1496.673815 1.443250825 2.24E-09 1.46E-06 SDC3 ENSG00000162512 1014.810244 1.497079252 2.73E-09 1.66E-06 AREG ENSG00000109321 2837.60822 1.95779015 3.30E-09 1.88E-06 CREG1 ENSG00000143162 12749.07956 1.147198128 3.41E-09 1.88E-06 NOTCH3 ENSG00000074181 180.9989827 1.858014709 3.37E-09 1.88E-06 P2RY1 ENSG00000169860 1095.428194 1.810396719 4.51E-09 2.22E-06 DAP ENSG00000112977 6125.932469 0.570194039 5.78E-09 2.70E-06 DBP ENSG00000105516 796.5622303 -0.924327189 6.00E-09 2.73E-06 PLBD1 ENSG00000121316 38483.02004 1.414898793 7.03E-09 3.12E-06 CPT1A ENSG00000110090 10937.33661 0.682040641 7.19E-09 3.12E-06 FBP1 ENSG00000165140 5145.316875 1.159481841 7.46E-09 3.16E-06 LDHA ENSG00000134333 20888.91871 0.729661519 1.19E-08 4.74E-06 ABCA1 ENSG00000165029 4042.89305 1.533755093 1.24E-08 4.80E-06 SPRY2 ENSG00000136158 259.0711917 1.849009887 1.28E-08 4.86E-06 FAM89A ENSG00000182118 259.6312521 1.253660502 1.76E-08 6.25E-06 CDKN1C ENSG00000129757 638.7026409 -1.643834747 1.74E-08 6.25E-06 ARHGAP29 ENSG00000137962 411.2068271 1.654320822 1.78E-08 6.25E-06 TRPV4 ENSG00000111199 324.5583528 1.369646134 2.02E-08 6.95E-06

FAM110A ENSG00000125898 2342.250362 -1.002199722 2.11E-08 7.00E-06 GPR84 ENSG00000139572 200.3198184 1.52045831 2.08E-08 7.00E-06 JDP2 ENSG00000140044 6635.866318 1.556821454 2.26E-08 7.37E-06 RNF141 ENSG00000110315 8936.441669 0.811348563 2.85E-08 8.80E-06 DDIT4 ENSG00000168209 14930.2361 1.558144034 2.83E-08 8.80E-06 RAB20 ENSG00000139832 2675.426394 1.311583907 2.96E-08 8.98E-06 COTL1 ENSG00000103187 77170.15048 0.827280441 4.45E-08 1.25E-05 GAPDH ENSG00000111640 127461.3503 0.68280341 4.54E-08 1.25E-05 DSC2 ENSG00000134755 2051.530337 1.364860788 4.54E-08 1.25E-05 F5 ENSG00000198734 7497.089081 1.21682844 4.46E-08 1.25E-05 LPCAT3 ENSG00000111684 2977.345231 0.609796431 4.75E-08 1.29E-05 VSIG4 ENSG00000155659 3672.159435 2.162788159 5.17E-08 1.35E-05 CD93 ENSG00000125810 26655.99916 1.145387252 5.19E-08 1.35E-05 EPB41L3 ENSG00000082397 4920.400653 1.054851617 5.37E-08 1.38E-05 ALCAM ENSG00000170017 2660.689806 0.952584288 6.43E-08 1.63E-05 SERPINB1 ENSG00000021355 28387.29997 0.985251204 7.04E-08 1.73E-05 ECHDC3 ENSG00000134463 1154.664839 1.676976174 7.12E-08 1.73E-05 RGL1 ENSG00000143344 661.7700039 1.417778518 7.86E-08 1.86E-05 UPP1 ENSG00000183696 15700.60585 1.006109358 8.07E-08 1.86E-05 UBASH3B ENSG00000154127 3606.962285 0.644494531 7.99E-08 1.86E-05 DYSF ENSG00000135636 19182.09042 1.358838709 1.10E-07 2.47E-05 GRINA ENSG00000178719 6519.816362 0.786716858 1.17E-07 2.58E-05 NOCT ENSG00000151014 841.1170191 1.486530322 1.20E-07 2.61E-05 S100A9 ENSG00000163220 316864.3473 1.328842697 1.29E-07 2.73E-05 CERS6 ENSG00000172292 4774.175262 0.681329877 1.28E-07 2.73E-05 TGM2 ENSG00000198959 1201.677982 1.809076033 1.45E-07 3.00E-05 CDK10 ENSG00000185324 3886.799198 -0.546159069 1.43E-07 3.00E-05 CORO6 ENSG00000167549 225.4483404 -1.140364894 1.64E-07 3.33E-05 PKM ENSG00000067225 40185.10522 0.594177506 1.64E-07 3.33E-05 TRMT6 ENSG00000089195 2478.206686 0.870602361 1.94E-07 3.80E-05 PGAM1 ENSG00000171314 13294.65182 0.668220456 1.92E-07 3.80E-05 HMGB3 ENSG00000029993 742.2291084 1.177267948 2.02E-07 3.88E-05 MAPRE1 ENSG00000101367 13652.65044 0.441351742 2.02E-07 3.88E-05 MICU1 ENSG00000107745 4748.03434 0.696049967 2.28E-07 4.29E-05 ADAM9 ENSG00000168615 2819.509489 1.08768189 2.36E-07 4.35E-05 SAMSN1 ENSG00000155307 12206.11937 1.304209231 2.34E-07 4.35E-05 KYNU ENSG00000115919 5273.351927 1.190949319 2.48E-07 4.53E-05 GADD45A ENSG00000116717 1426.073343 1.169420098 2.64E-07 4.67E-05 S100A8 ENSG00000143546 100245.9685 1.376831465 3.04E-07 5.08E-05 SMIM3 ENSG00000256235 2469.389453 1.182289259 3.44E-07 5.65E-05 XRN2 ENSG00000088930 13514.64358 0.543206587 3.64E-07 5.93E-05 FCGR1A ENSG00000150337 2098.120163 1.159032011 3.87E-07 6.19E-05 SDC2 ENSG00000169439 176.4079929 1.73865011 4.08E-07 6.36E-05 GHITM ENSG00000165678 13288.57283 0.414302223 4.42E-07 6.77E-05 OLIG1 ENSG00000184221 417.8914903 -1.304078794 4.83E-07 7.33E-05 DLC1 ENSG00000164741 115.757074 1.369669159 5.15E-07 7.69E-05

SPRED2 ENSG00000198369 386.0404468 1.143210017 5.51E-07 8.12E-05 ANKRD22 ENSG00000152766 404.6701773 1.445992167 5.52E-07 8.12E-05 SLCO4A1 ENSG00000101187 169.7784101 1.60866957 5.61E-07 8.19E-05 C5AR1 ENSG00000197405 21359.77758 1.123261656 5.88E-07 8.50E-05 RNASE1 ENSG00000129538 360.8390322 1.825315688 6.24E-07 8.95E-05 SMPDL3A ENSG00000172594 1556.876137 1.048661976 6.47E-07 9.22E-05 SLCO2B1 ENSG00000137491 47.83829708 1.871018038 6.71E-07 9.48E-05 APLP2 ENSG00000084234 75942.07281 0.866178255 7.44E-07 0.000102792 CXCL16 ENSG00000161921 5750.821314 0.969989363 7.65E-07 0.000104821 CDIP1 ENSG00000089486 1706.978694 -0.741522979 8.39E-07 0.0001142 SNRNP70 ENSG00000104852 15254.77736 -0.402418952 8.71E-07 0.000116711 C5orf66 ENSG00000224186 120.3696587 1.052061134 9.11E-07 0.000121221 CES1 ENSG00000198848 5813.116946 1.521822921 1.01E-06 0.00013217 ELL2 ENSG00000118985 3566.304589 1.178543753 1.03E-06 0.000133431 COPA ENSG00000122218 15565.78696 0.464026566 1.08E-06 0.000138738 CRELD1 ENSG00000163703 1348.300425 -0.634173128 1.11E-06 0.000141032 PTGER2 ENSG00000125384 10391.67758 0.833689799 1.22E-06 0.000153318 HSPA4 ENSG00000170606 5253.243252 0.42584 1.24E-06 0.000154754 FPR2 ENSG00000171049 2326.720925 1.443558821 1.26E-06 0.000156465 SORCS2 ENSG00000184985 589.4739001 1.145962486 1.43E-06 0.000174195 IRAK3 ENSG00000090376 12709.56191 1.183145719 1.46E-06 0.000175296 SAP30 ENSG00000164105 2992.512822 1.441078159 1.46E-06 0.000175296 ST6GALNAC3 ENSG00000184005 901.0550904 1.376308061 1.51E-06 0.000179743 MPP1 ENSG00000130830 6817.598777 0.789303364 1.68E-06 0.000196514 GNA15 ENSG00000060558 3668.022319 0.912548179 1.72E-06 0.000198804 HADHB ENSG00000138029 10465.15516 0.604209571 1.77E-06 0.000202683 FAM49B ENSG00000153310 17197.36185 0.576810496 1.98E-06 0.000225987 SMAD1 ENSG00000170365 455.2487638 1.036768307 2.01E-06 0.000227317 SOCS6 ENSG00000170677 873.7307252 0.79075511 2.09E-06 0.000232621 FAM160B2 ENSG00000158863 4745.412597 -0.564552185 2.16E-06 0.000237658 MLXIPL ENSG00000009950 38.01109936 1.870575191 2.18E-06 0.00023788 FGR ENSG00000000938 73333.48229 0.665099942 2.21E-06 0.000239847 SLC1A3 ENSG00000079215 195.6395358 1.653016879 2.34E-06 0.000252188 HCCS ENSG00000004961 761.9020775 0.601119319 2.35E-06 0.000252285 SLC44A1 ENSG00000070214 4133.959697 0.82256594 2.39E-06 0.000254826 SDC4 ENSG00000124145 633.4815502 1.607536133 2.48E-06 0.000261814 CTSB ENSG00000164733 42499.33404 1.142298738 2.48E-06 0.000261814 CEBPB ENSG00000172216 9983.30849 1.201661808 2.60E-06 0.00027269 LPCAT4 ENSG00000176454 2349.109657 -0.645620612 2.71E-06 0.000282258 CLTC ENSG00000141367 15619.50685 0.548921447 2.82E-06 0.00029213 GPCPD1 ENSG00000125772 28518.11554 0.680257716 2.92E-06 0.000300248 EDNRB ENSG00000136160 56.1881398 1.827939819 3.02E-06 0.000306094 NUS1 ENSG00000153989 5985.189789 0.478137145 3.06E-06 0.000307867 GPR82 ENSG00000171657 87.57977605 1.296833508 3.09E-06 0.000309826 YPEL2 ENSG00000175155 2427.192761 1.522766836 3.15E-06 0.000313261 DNAJC7 ENSG00000168259 4938.465091 0.603900859 3.18E-06 0.000313261

MYO7A ENSG00000137474 1569.938783 1.404457743 3.36E-06 0.000327413 ITGA9 ENSG00000144668 413.7175551 1.592485151 3.65E-06 0.000348459 UBE2E1 ENSG00000170142 6707.771361 0.39405358 4.03E-06 0.000380223 TBXAS1 ENSG00000059377 16274.60575 0.808714287 4.16E-06 0.000390969 SLC29A2 ENSG00000174669 433.3821209 -0.886312543 4.25E-06 0.000395753 LUC7L ENSG00000007392 5531.706412 -0.469216124 4.53E-06 0.000418963 C9orf72 ENSG00000147894 15680.66772 0.831086696 4.64E-06 0.000425023 P3H4 ENSG00000141696 155.3166495 -0.987061949 4.70E-06 0.000428609 GRM2 ENSG00000164082 315.0652962 -0.850548273 4.97E-06 0.000446044 GSR ENSG00000104687 5857.109287 0.608387815 4.97E-06 0.000446044 NLRP3 ENSG00000162711 8135.304622 0.884043152 5.00E-06 0.000447228 ANO10 ENSG00000160746 1356.261825 0.751571311 5.25E-06 0.000466094 SRGN ENSG00000122862 107406.5828 0.989244816 5.29E-06 0.000466094 TM9SF2 ENSG00000125304 18118.66771 0.557327257 5.39E-06 0.000470157 UBE2R2 ENSG00000107341 10421.28848 0.617992186 5.46E-06 0.000472144 ZDHHC9 ENSG00000188706 332.590522 0.506783592 5.46E-06 0.000472144 STK32B ENSG00000152953 150.931684 0.969798671 5.51E-06 0.000474099 MTHFD2 ENSG00000065911 3790.79033 0.733346117 5.57E-06 0.000476521 IMPA2 ENSG00000141401 2799.161693 0.795894196 5.96E-06 0.000506 NECTIN2 ENSG00000130202 697.0341103 1.043285012 5.97E-06 0.000506 F12 ENSG00000131187 233.8526484 1.040740721 6.00E-06 0.000506499 GTF2F2 ENSG00000188342 1256.58503 0.620855577 6.11E-06 0.000513177 LIN7B ENSG00000104863 223.5015883 -0.736168274 6.37E-06 0.000532655 CAPRIN1 ENSG00000135387 12679.89284 0.39126661 6.60E-06 0.000544345 RNASE2 ENSG00000169385 5782.116548 1.47550793 6.88E-06 0.000562104 PSMC1 ENSG00000100764 5884.781043 0.434364259 6.85E-06 0.000562104 FAM20C ENSG00000177706 1538.540455 0.985329097 7.12E-06 0.000576645 CD36 ENSG00000135218 27194.03905 1.108187355 7.23E-06 0.000582962 ZNF80 ENSG00000174255 219.8667359 -1.223720185 7.60E-06 0.000605178 TMEM167A ENSG00000174695 12533.80338 0.630186836 7.64E-06 0.000605178 ITGAM ENSG00000169896 41544.2399 0.716240961 7.83E-06 0.000615411 CENPT ENSG00000102901 3535.786328 -0.554557536 7.99E-06 0.000624826 SLC16A6 ENSG00000108932 3751.188703 0.994794958 8.05E-06 0.000626796 CAPZB ENSG00000077549 20527.83286 0.378487461 8.14E-06 0.000628575 HLX ENSG00000136630 1942.632695 0.983335686 8.17E-06 0.000628718 DRAM1 ENSG00000136048 1016.722322 1.058480525 8.46E-06 0.000647648 PGK1 ENSG00000102144 29966.49996 0.522325763 8.49E-06 0.000647719 MAN1A1 ENSG00000111885 10025.19115 0.773546927 8.55E-06 0.000649084 CLIC4 ENSG00000169504 4129.262503 0.769814711 8.76E-06 0.000662594 XRCC4 ENSG00000152422 882.4483279 0.654736415 8.84E-06 0.000666114 DNAH17 ENSG00000187775 2926.818123 0.910360012 9.03E-06 0.000677742 CHIT1 ENSG00000133063 252.7867442 1.590377399 9.19E-06 0.000686571 ACVRL1 ENSG00000139567 268.2722706 1.320147417 9.28E-06 0.000690202 TMEM132D ENSG00000151952 38.93692815 1.579656411 9.37E-06 0.00069468 MS4A4A ENSG00000110079 1122.17405 1.31260589 9.78E-06 0.000721775 KLHL2 ENSG00000109466 5270.044363 0.878505471 9.83E-06 0.000722674

PICALM ENSG00000073921 25880.05401 0.619925342 9.91E-06 0.000725311 MYO10 ENSG00000145555 200.977054 1.050588769 9.97E-06 0.000727231 NOA1 ENSG00000084092 2356.665783 0.29805308 1.01E-05 0.000730317 MRPS35 ENSG00000061794 2279.14376 0.428896132 1.04E-05 0.000749581 TFAP2E ENSG00000116819 1062.614824 -0.589669037 1.04E-05 0.000751847 ERLIN2 ENSG00000147475 2478.624002 0.532762983 1.08E-05 0.00077423 GAS7 ENSG00000007237 20277.31523 0.886809738 1.11E-05 0.000788102 SEC11A ENSG00000140612 7295.666713 0.468517868 1.13E-05 0.000801824 ALAS1 ENSG00000023330 3189.486887 0.688901096 1.16E-05 0.000815899 FFAR2 ENSG00000126262 1353.620405 1.442163809 1.20E-05 0.00083798 CCNY ENSG00000108100 12774.93104 0.481333893 1.21E-05 0.00084341 ICA1 ENSG00000003147 476.7647308 0.993857213 1.23E-05 0.000854095 DOCK1 ENSG00000150760 174.843324 1.2243053 1.24E-05 0.000857108 ACSL3 ENSG00000123983 3062.063838 0.681450529 1.25E-05 0.000857108 NUP58 ENSG00000139496 4230.181693 0.438686284 1.28E-05 0.000872349 SKAP2 ENSG00000005020 8878.397316 0.799144823 1.30E-05 0.000883701 G6PD ENSG00000160211 9003.219864 0.597244494 1.32E-05 0.000893347 PRMT7 ENSG00000132600 2226.32413 -0.53370847 1.34E-05 0.000904128 SLA ENSG00000155926 25952.49596 1.274673345 1.36E-05 0.000912014 HEXIM1 ENSG00000186834 4883.094784 -0.305964308 1.36E-05 0.000912328 ENO2 ENSG00000111674 2152.100475 -0.832373964 1.39E-05 0.00092803 MAP2K1 ENSG00000169032 7761.812816 0.589185687 1.41E-05 0.000936788 PLEKHG3 ENSG00000126822 5069.819107 -0.768190942 1.53E-05 0.001005276 SERBP1 ENSG00000142864 13664.50973 0.279413518 1.59E-05 0.001034221 CD1D ENSG00000158473 6656.72901 0.747471466 1.60E-05 0.001034221 BCAT1 ENSG00000060982 1526.458865 1.180585096 1.59E-05 0.001034221 TIMP1 ENSG00000102265 14201.56418 1.146658422 1.63E-05 0.001043561 CHST15 ENSG00000182022 15934.13574 0.786822368 1.63E-05 0.001043748 ZDHHC3 ENSG00000163812 4259.382577 0.553633145 1.64E-05 0.001046333 UBTD1 ENSG00000165886 664.5761964 0.899821297 1.70E-05 0.001051584 HIPK2 ENSG00000064393 10950.81618 0.731653316 1.68E-05 0.001051584 PLXNC1 ENSG00000136040 10781.92915 0.911865787 1.70E-05 0.001051584 NTN4 ENSG00000074527 201.2790517 -1.29171039 1.69E-05 0.001051584 CNTLN ENSG00000044459 912.0690335 0.931611154 1.69E-05 0.001051584 ANKRD34B ENSG00000189127 384.2892257 1.337786758 1.70E-05 0.001051584 LAPTM5 ENSG00000162511 176491.6169 0.533717266 1.72E-05 0.001058874 HDAC6 ENSG00000094631 4997.992888 -0.264205397 1.78E-05 0.001090191 DNTTIP1 ENSG00000101457 2470.162042 0.653089709 1.80E-05 0.001095855 CELSR2 ENSG00000143126 639.3029119 -0.64741573 1.80E-05 0.001095855 HERPUD1 ENSG00000051108 10388.34546 0.660080519 1.85E-05 0.001118924 FKBP5 ENSG00000096060 19926.90272 1.054419517 1.85E-05 0.001118924 GUCY2C ENSG00000070019 675.6108032 1.112554059 1.87E-05 0.001125307 OPA1 ENSG00000198836 5330.763175 0.417224815 1.90E-05 0.001137326 INPP5E ENSG00000148384 1960.576155 -0.523618096 1.90E-05 0.001137326 GSG2 ENSG00000177602 120.3684424 1.115672982 1.91E-05 0.001137599 PTGES ENSG00000148344 189.8252143 1.535861129 1.92E-05 0.001142884

AGTPBP1 ENSG00000135049 17499.47401 0.536479376 2.04E-05 0.001194834 MARCH9 ENSG00000139266 1760.803478 -0.672910454 2.04E-05 0.001194834 MMS19 ENSG00000155229 5334.538313 -0.244897763 2.07E-05 0.001202968 PSMB7 ENSG00000136930 7605.00203 0.299161508 2.07E-05 0.001202968 GARS ENSG00000106105 4305.357874 0.393007753 2.08E-05 0.001206605 SIL1 ENSG00000120725 1601.333908 0.543377387 2.16E-05 0.00124127 MGAT1 ENSG00000131446 20360.09019 0.672040082 2.20E-05 0.001259403 ALDOA ENSG00000149925 36281.94574 0.47215665 2.22E-05 0.001266546 MTMR14 ENSG00000163719 8328.486376 0.433361933 2.28E-05 0.001284379 VIM ENSG00000026025 164541.2805 0.71091723 2.28E-05 0.001284379 H2AFY ENSG00000113648 25919.78122 0.665218978 2.28E-05 0.001284379 EPS15 ENSG00000085832 10418.90561 0.351763895 2.28E-05 0.001284379 ST8SIA4 ENSG00000113532 7571.298366 0.611528108 2.36E-05 0.001325745 PLAA ENSG00000137055 2930.978707 0.492294756 2.55E-05 0.001416769 NEDD4L ENSG00000049759 500.0885489 0.732109054 2.56E-05 0.001420628 SASH1 ENSG00000111961 1512.517338 1.092748004 2.59E-05 0.001431365 TCEB1 ENSG00000154582 1765.107627 0.381231028 2.60E-05 0.001432695 ANKRD13B ENSG00000198720 147.8919303 -0.76087776 2.69E-05 0.001473287 LCP1 ENSG00000136167 174159.6861 0.538427425 2.74E-05 0.0014843 KHDRBS1 ENSG00000121774 5540.127238 0.269086517 2.76E-05 0.001490466 LYN ENSG00000254087 27018.35837 0.756766553 2.90E-05 0.001559926 COL6A2 ENSG00000142173 3747.338855 -1.098145903 2.91E-05 0.001559926 OLA1 ENSG00000138430 3674.181293 0.437592889 2.93E-05 0.00156397 HADHA ENSG00000084754 20219.19038 0.442252443 2.93E-05 0.00156397 SEZ6L ENSG00000100095 270.8283168 -0.888123406 2.96E-05 0.001574377 ICAM1 ENSG00000090339 6662.879143 1.000134606 3.10E-05 0.001627084 RIT1 ENSG00000143622 5592.546194 0.823147165 3.14E-05 0.00163588 SEC24D ENSG00000150961 3314.163024 0.630046932 3.28E-05 0.001697002 B4GALT5 ENSG00000158470 8945.185915 0.970750523 3.31E-05 0.001707555 TKT ENSG00000163931 51714.67877 0.582606144 3.33E-05 0.001707987 TALDO1 ENSG00000177156 20702.47418 0.660961468 3.32E-05 0.001707987 ACYP1 ENSG00000119640 633.2395149 -0.77294421 3.38E-05 0.001715932 ACER3 ENSG00000078124 2367.728805 1.258933355 3.38E-05 0.001715932 CHMP4B ENSG00000101421 12774.30797 0.424717311 3.44E-05 0.001724425 NUP214 ENSG00000126883 7033.440163 0.274990251 3.45E-05 0.001724425 RALGDS ENSG00000160271 8693.470148 -0.645488042 3.58E-05 0.001772969 PECAM1 ENSG00000261371 45415.95324 0.715296018 3.59E-05 0.001773903 MSRB2 ENSG00000148450 1193.853764 0.747636826 3.62E-05 0.001782701 TBL2 ENSG00000106638 916.3826209 0.569848155 3.65E-05 0.001793554 MSR1 ENSG00000038945 1638.645283 1.14447593 3.69E-05 0.001805121 PIEZO1 ENSG00000103335 13263.90428 -0.483606918 3.77E-05 0.001836102 CFP ENSG00000126759 20165.61072 0.687390283 3.79E-05 0.001844857 BCL2L11 ENSG00000153094 4397.883262 1.2191284 3.90E-05 0.001888796 SNX3 ENSG00000112335 8462.427986 0.527132516 3.96E-05 0.00190263 IFNGR1 ENSG00000027697 22906.11495 0.980888957 3.99E-05 0.001915494 LMBRD1 ENSG00000168216 5394.468286 0.501200062 4.01E-05 0.001918334

C11orf21 ENSG00000110665 8185.658373 -0.641005241 4.13E-05 0.001971832 FAM198B ENSG00000164125 9899.126808 1.122235341 4.16E-05 0.001976729 ARHGAP24 ENSG00000138639 2252.587282 1.032318911 4.16E-05 0.001976729 LSS ENSG00000160285 2534.615274 -0.557834486 4.22E-05 0.001998131 HMOX1 ENSG00000100292 11510.65501 0.831460815 4.26E-05 0.002011403 VAT1 ENSG00000108828 2926.746961 0.653103571 4.28E-05 0.002013643 CSGALNACT2 ENSG00000169826 23174.29579 0.84671384 4.29E-05 0.002013643 STEAP4 ENSG00000127954 3124.085 1.115354301 4.31E-05 0.002017568 FNDC3B ENSG00000075420 4240.430357 0.726785142 4.37E-05 0.002042077 LAMP2 ENSG00000005893 12962.47936 0.714970438 4.47E-05 0.002077006 IFNGR2 ENSG00000159128 12570.73018 0.67590041 4.57E-05 0.0021141 COPS3 ENSG00000141030 2499.68862 0.501566064 4.62E-05 0.00212544 SCPEP1 ENSG00000121064 13264.3406 0.660491332 4.62E-05 0.00212544 PLD4 ENSG00000166428 1038.998295 -1.049179184 4.72E-05 0.002156202 WASF1 ENSG00000112290 341.7295373 0.816829679 4.70E-05 0.002156202 RP11-403I13.8 ENSG00000272419 2323.701175 -0.547687453 4.73E-05 0.002156914 PXMP4 ENSG00000101417 486.9136524 -0.556968476 4.77E-05 0.00216665 RBM47 ENSG00000163694 5514.659319 0.886076299 4.79E-05 0.002170421 KCNQ1 ENSG00000053918 4096.938345 0.485463973 4.83E-05 0.002180661 SSBP3 ENSG00000157216 5194.576744 -0.409999928 4.94E-05 0.002216349 SEMA4A ENSG00000196189 8659.607066 0.613995109 4.95E-05 0.002216349 CCL24 ENSG00000106178 90.9454351 1.667206787 4.98E-05 0.002226091 SOAT1 ENSG00000057252 7260.300169 0.587295674 5.04E-05 0.002242839 PKD2L1 ENSG00000107593 81.95210311 1.455601134 5.13E-05 0.002270937 NFIL3 ENSG00000165030 8774.418211 1.071792231 5.20E-05 0.002291526 CTSA ENSG00000064601 16636.23351 0.615909911 5.22E-05 0.002291526 QSOX1 ENSG00000116260 8455.408086 0.690209726 5.23E-05 0.002291526 GLUL ENSG00000135821 47165.11421 0.888859787 5.25E-05 0.002294129 PPIF ENSG00000108179 8199.39333 1.090802867 5.31E-05 0.002315715 B3GALNT1 ENSG00000169255 48.65304963 1.212446884 5.34E-05 0.002316004 SH3RF3 ENSG00000172985 327.3366555 0.865933615 5.33E-05 0.002316004 KCNE1 ENSG00000180509 1379.558907 1.131532383 5.38E-05 0.002329601 LTA4H ENSG00000111144 34399.01807 0.865719294 5.52E-05 0.002380894 ENO1 ENSG00000074800 45825.95868 0.492751528 5.52E-05 0.002380894 PRKACA ENSG00000072062 11090.47995 0.524008374 5.55E-05 0.002386285 CCDC157 ENSG00000187860 223.9043878 -0.75515912 5.66E-05 0.002426045 EXD3 ENSG00000187609 971.9733226 -0.549356386 5.74E-05 0.002449939 THEMIS2 ENSG00000130775 29950.28197 0.714194431 6.01E-05 0.002545285 TBC1D30 ENSG00000111490 313.0955785 0.758979592 6.12E-05 0.002564365 RNF175 ENSG00000145428 901.0465494 0.847987192 6.10E-05 0.002564365 EXT1 ENSG00000182197 2120.486025 0.579096212 6.14E-05 0.002568848 STARD3NL ENSG00000010270 2742.34801 0.46935856 6.20E-05 0.002585677 SEMA4F ENSG00000135622 620.562476 -0.618583157 6.25E-05 0.002601941 ZNF185 ENSG00000147394 4682.896505 0.665260023 6.33E-05 0.002615896 CD63 ENSG00000135404 13040.82964 0.731928396 6.33E-05 0.002615896 TMEM135 ENSG00000166575 833.3638242 0.827253057 6.61E-05 0.002713183

ADIPOR1 ENSG00000159346 16355.44651 0.655045227 6.66E-05 0.00271853 S100P ENSG00000163993 1445.26333 1.531369758 6.64E-05 0.00271853 CAPZA1 ENSG00000116489 11542.24686 0.652102159 6.68E-05 0.002719041 PANX2 ENSG00000073150 410.9189705 1.191333391 6.85E-05 0.002771511 DNAJC3 ENSG00000102580 6627.567857 0.624716714 6.93E-05 0.00278778 PCOLCE ENSG00000106333 390.766887 -0.549464734 7.05E-05 0.002832019 BTF3L4 ENSG00000134717 2210.667515 0.486339534 7.12E-05 0.002852932 GRB10 ENSG00000106070 1976.006384 1.280744094 7.14E-05 0.002855267 AP3S1 ENSG00000177879 4428.097372 0.537287213 7.25E-05 0.002892138 PELI2 ENSG00000139946 5328.697913 0.691000945 7.28E-05 0.002892138 SH2B1 ENSG00000178188 4896.692225 -0.411241404 7.32E-05 0.002894794 RBBP8 ENSG00000101773 1421.033176 0.582223575 7.36E-05 0.002898796 CA1 ENSG00000133742 366.2498507 1.585826508 7.49E-05 0.002941432 MBD2 ENSG00000134046 12371.50083 0.468383225 7.57E-05 0.002949778 MFF ENSG00000168958 4437.055418 0.289224184 7.64E-05 0.00296409 LLGL1 ENSG00000131899 1825.935687 -0.45051521 7.71E-05 0.002977851 C17orf67 ENSG00000214226 823.5857062 -0.476438597 7.70E-05 0.002977851 ZMYM3 ENSG00000147130 2457.986091 -0.423030488 7.73E-05 0.002981081 AZIN1 ENSG00000155096 7244.812807 0.607322086 7.81E-05 0.002996374 FOXO3 ENSG00000118689 10348.29444 0.879651356 7.79E-05 0.002996374 TPST1 ENSG00000169902 1186.112342 1.38130108 7.85E-05 0.003001768 CAT ENSG00000121691 13302.32419 0.696938849 7.85E-05 0.003001768 TFRC ENSG00000072274 6690.519544 0.646447073 7.97E-05 0.003038543 ACTG1 ENSG00000184009 60711.4474 0.434014942 8.04E-05 0.003061315 PLB1 ENSG00000163803 2377.126512 0.805862978 8.08E-05 0.003069734 DGAT2 ENSG00000062282 2717.878097 1.229264696 8.17E-05 0.003090364 SPOCK1 ENSG00000152377 299.4492735 0.882011338 8.19E-05 0.003091897 UQCRC2 ENSG00000140740 10566.1786 0.276856492 8.21E-05 0.003092963 RRAGD ENSG00000025039 1295.60347 0.788635848 8.32E-05 0.003119674 DAPK1 ENSG00000196730 10452.60068 0.704998349 8.36E-05 0.003127931 XXYLT1 ENSG00000173950 1597.553673 0.698767645 8.49E-05 0.003167428 NRAS ENSG00000213281 7061.317335 0.725100216 8.59E-05 0.003194009 CLTA ENSG00000122705 4301.195957 0.521475732 8.60E-05 0.003194009 CPQ ENSG00000104324 4987.35183 0.638652145 8.69E-05 0.003205665 NPRL2 ENSG00000114388 1799.39399 -0.466277455 8.77E-05 0.003217637 LAMC1 ENSG00000135862 924.7826857 1.152964595 8.77E-05 0.003217637 TSC2 ENSG00000103197 7635.467924 -0.314580497 8.94E-05 0.003253888 CDH5 ENSG00000179776 43.93778888 1.595362201 8.96E-05 0.003253888 NCSTN ENSG00000162736 13500.59444 0.408011259 8.96E-05 0.003253888 SLC36A4 ENSG00000180773 2836.884212 0.742396131 8.93E-05 0.003253888 NMNAT2 ENSG00000157064 56.04233964 1.263139616 8.90E-05 0.003253888 CPD ENSG00000108582 11848.90425 0.767621804 9.40E-05 0.003401005 SPA17 ENSG00000064199 144.2817047 0.890243921 9.50E-05 0.003430073 OAT ENSG00000065154 3430.726018 0.509022967 9.55E-05 0.003441138 SMAP2 ENSG00000084070 56547.16091 0.799053677 9.70E-05 0.003486934 VDAC2 ENSG00000165637 5141.657561 0.353539975 9.87E-05 0.003540674

SLC28A3 ENSG00000197506 308.2269581 1.274656838 9.90E-05 0.003545505 MAP10 ENSG00000212916 180.6880751 0.680847168 9.96E-05 0.003560612 PTBP2 ENSG00000117569 2411.174504 0.967253166 0.000101329 0.003595279 PALLD ENSG00000129116 2134.087344 0.910209797 0.000101165 0.003595279 VPS25 ENSG00000131475 1513.586713 0.369672915 0.000102538 0.003622594 BFAR ENSG00000103429 1912.690586 0.459857904 0.000105293 0.003698443 PYGL ENSG00000100504 14614.55524 0.88612144 0.000106558 0.003735671 CDK5R1 ENSG00000176749 946.5846091 0.843200262 0.000107325 0.003748168 SDC1 ENSG00000115884 50.5447213 1.566092422 0.00010713 0.003748168 IL1R1 ENSG00000115594 1866.32003 1.351584094 0.000108487 0.003781494 NFIA ENSG00000162599 436.3778739 1.216526088 0.000109109 0.003788697 PCDH12 ENSG00000113555 418.4364625 -0.447562394 0.000110611 0.003833543 PCBP1 ENSG00000169564 26514.13676 0.379913594 0.00011131 0.003836538 GCA ENSG00000115271 14365.32436 1.014427639 0.00011106 0.003836538 SDHB ENSG00000117118 4959.61996 0.366323741 0.000111905 0.003849116 TMX1 ENSG00000139921 3870.469096 0.674073969 0.000115401 0.003885573 TXNL1 ENSG00000091164 5252.058612 0.337375165 0.000115179 0.003885573 UBE2D3 ENSG00000109332 30483.64943 0.331126627 0.000115021 0.003885573 C10orf11 ENSG00000148655 364.238377 0.704240347 0.000115448 0.003885573 SPTLC1 ENSG00000090054 3816.241319 0.489139941 0.000114279 0.003885573 ADGRB2 ENSG00000121753 190.2257326 -1.099398272 0.000115625 0.003885573 SMAP1 ENSG00000112305 3352.186912 0.320576949 0.000114296 0.003885573 PAPSS1 ENSG00000138801 3582.375232 0.55615165 0.000117264 0.003929653 CYP4F22 ENSG00000171954 144.380418 -1.196674887 0.000118828 0.003973411 CDC42 ENSG00000070831 36840.98282 0.347391205 0.00012062 0.004019945 TMEM45A ENSG00000181458 66.82839947 1.552717569 0.000123739 0.004093927 BNIP2 ENSG00000140299 10552.96736 0.595032502 0.000126414 0.004159809 GMDS ENSG00000112699 1063.584593 0.393660554 0.000128023 0.004188055 ELMO1 ENSG00000155849 4344.831078 0.402558299 0.000128192 0.004188055 ANPEP ENSG00000166825 26382.89312 0.747708526 0.000129659 0.004228422 RFWD2 ENSG00000143207 4146.283192 0.545031128 0.000130037 0.004233167 ME1 ENSG00000065833 292.9768961 1.139817285 0.000132384 0.004286624 ROBO3 ENSG00000154134 458.2883603 -0.791366017 0.000134897 0.004360225 CTTNBP2 ENSG00000077063 76.56424815 1.436415599 0.00013763 0.004438551 ZFAND3 ENSG00000156639 7722.815193 0.454491922 0.000137853 0.004438551 BOK ENSG00000176720 116.078219 -1.360544202 0.000138294 0.004438551 GDPD5 ENSG00000158555 3436.157553 -0.760978242 0.000139462 0.004454267 TIPARP ENSG00000163659 9980.039878 1.089234676 0.000139517 0.004454267 MAP1LC3B ENSG00000140941 4231.983111 0.659699619 0.000141143 0.004498308 IL1R2 ENSG00000115590 4692.339185 1.560403257 0.000141659 0.004506877 CRIP2 ENSG00000182809 660.9416077 -0.984798224 0.000143097 0.004544715 ANXA11 ENSG00000122359 17769.12938 0.435398018 0.000143798 0.004552836 CALU ENSG00000128595 2908.183771 0.612442865 0.000145403 0.004562303 FAM167B ENSG00000183615 58.9059701 -1.118285756 0.000144461 0.004562303 ATP6V0D1 ENSG00000159720 10209.98118 0.596413281 0.000145051 0.004562303 UBXN2B ENSG00000215114 6240.907571 0.653649318 0.000144847 0.004562303

ABCA3 ENSG00000167972 616.8409513 -0.654055139 0.000145399 0.004562303 PCDH1 ENSG00000156453 170.1235363 -1.335465282 0.000147031 0.004597571 SEC24A ENSG00000113615 2773.635683 0.584805853 0.000148882 0.004636603 PSMD13 ENSG00000185627 5032.661521 0.316462387 0.000149985 0.004657966 AC013461.1 ENSG00000091436 2631.905653 0.702130752 0.000151448 0.004695392 CD1C ENSG00000158481 1009.051515 -0.782779599 0.000152442 0.004703557 SRPK1 ENSG00000096063 5193.978582 0.578983473 0.000152135 0.004703557 SNX4 ENSG00000114520 1822.614967 0.43916148 0.000152866 0.004707344 PPOX ENSG00000143224 1372.990652 -0.539183851 0.000153883 0.004730677 SH2B2 ENSG00000160999 988.9262485 0.639638967 0.000154998 0.004756926 CMTM6 ENSG00000091317 18833.13774 0.550023077 0.000156328 0.00477363 RP2 ENSG00000102218 3820.134874 0.672789935 0.000156817 0.004780547 ZMIZ1 ENSG00000108175 13828.04865 0.588465569 0.000158487 0.004823406 KLF9 ENSG00000119138 12467.3547 0.95918061 0.000159339 0.004841258 MT1F ENSG00000198417 297.6578627 0.788325273 0.000168031 0.00505479 HIST1H1C ENSG00000187837 1040.725698 0.759210773 0.000168583 0.005063049 PPT1 ENSG00000131238 27811.44511 0.664578725 0.000172451 0.005145777 GRIK1 ENSG00000171189 71.15107513 0.89586545 0.000179376 0.005317106 ZNF106 ENSG00000103994 12606.4561 0.503433253 0.000179693 0.005317861 HRH2 ENSG00000113749 8802.285496 0.757439071 0.00018069 0.00533231 MMP14 ENSG00000157227 889.993829 0.912925553 0.000180766 0.00533231 LMBR1 ENSG00000105983 2739.438757 0.37063115 0.000182427 0.005347467 BNIP3L ENSG00000104765 12989.87823 0.807264446 0.00018238 0.005347467 DOPEY2 ENSG00000142197 4043.221054 0.437960972 0.000184656 0.005386043 MSH3 ENSG00000113318 1282.483271 0.502012451 0.000184568 0.005386043 FOSB ENSG00000125740 3658.722953 -1.071567492 0.000187883 0.005445325 PTGFR ENSG00000122420 53.49503383 1.504665433 0.000187158 0.005445325 RAB2A ENSG00000104388 5309.921478 0.463054013 0.000189673 0.005479783 HGH1 ENSG00000235173 308.6999496 -0.696013397 0.000190952 0.005499311 DZANK1 ENSG00000089091 304.7199549 -0.474795012 0.000192347 0.005530721 HNRNPK ENSG00000165119 47121.61319 0.22704367 0.000192749 0.00553124 ZMYND19 ENSG00000165724 852.7294907 -0.535228242 0.000196924 0.005626837 COL9A3 ENSG00000092758 246.283554 0.959015032 0.000197581 0.005627963 SWAP70 ENSG00000133789 4280.207347 0.481565267 0.000200056 0.005671256 CNBP ENSG00000169714 24171.1749 0.378287355 0.000200273 0.005671256 CD82 ENSG00000085117 3551.152906 0.638579389 0.000200947 0.005679479 GALC ENSG00000054983 5114.205649 0.510087148 0.000204513 0.00577132 TMEM39A ENSG00000176142 3181.897467 0.583512565 0.000204967 0.005775185 TBKBP1 ENSG00000198933 1947.6216 -0.745569346 0.000206715 0.005815444 RAP1A ENSG00000116473 10920.40432 0.437737618 0.000209677 0.005862599 DNAJB12 ENSG00000148719 4365.611184 0.481989311 0.000211856 0.00591445 TCTN2 ENSG00000168778 296.6021471 -0.740530357 0.000212208 0.005915209 KIF20A ENSG00000112984 123.2451666 1.194080294 0.000214023 0.005947613 ZFAND5 ENSG00000107372 23929.03441 0.669749618 0.000214644 0.005951371 RNLS ENSG00000184719 153.2309786 0.631200479 0.000214831 0.005951371 ADAMTS2 ENSG00000087116 1521.501004 1.501658919 0.000218117 0.006006458

LIN7A ENSG00000111052 2789.755649 1.041215089 0.000217746 0.006006458 FAM110B ENSG00000169122 171.8509081 0.94979005 0.000217946 0.006006458 SUMF1 ENSG00000144455 2195.058738 0.504302572 0.000218499 0.00600789 MRPL15 ENSG00000137547 1091.289126 0.476453112 0.000219192 0.006017886 TARS ENSG00000113407 3294.311113 0.371594012 0.000220082 0.006033215 ZNF516 ENSG00000101493 3483.63522 0.861248445 0.000221659 0.006047823 C1QB ENSG00000173369 1028.147711 1.25934251 0.000221941 0.006047823 LSM6 ENSG00000164167 1293.635645 0.422399475 0.000222832 0.006063034 RIOK3 ENSG00000101782 8321.061203 0.592026143 0.000225962 0.006120792 GSTO1 ENSG00000148834 4997.963445 0.573198658 0.000226702 0.006131723 ELP6 ENSG00000163832 1070.122144 -0.352192591 0.000227836 0.006153263 METTL7B ENSG00000170439 86.81828391 1.514068869 0.000229241 0.006165865 DIAPH2 ENSG00000147202 2809.267397 0.546988248 0.000231697 0.006211529 SIGIRR ENSG00000185187 7779.008937 -0.652714092 0.000231533 0.006211529 HK2 ENSG00000159399 6760.218876 0.666187911 0.00023259 0.00622632 ADAM17 ENSG00000151694 6752.655274 0.626840448 0.000233791 0.006249278 DNAH8 ENSG00000124721 78.41752198 1.021906344 0.000237381 0.006335948 GKAP1 ENSG00000165113 449.5862093 -0.485473372 0.000240622 0.006394384 DOK3 ENSG00000146094 9153.276655 0.821661104 0.000240406 0.006394384 LAPTM4A ENSG00000068697 9339.172245 0.428008544 0.000242292 0.006420032 IRF3 ENSG00000126456 6335.241356 -0.458765424 0.000243403 0.00644011 TIGD5 ENSG00000179886 333.5266758 -0.572433446 0.000248126 0.006527192 CSDE1 ENSG00000009307 41016.10697 0.299288348 0.000248842 0.006536591 ETFA ENSG00000140374 3091.348082 0.375921727 0.000254699 0.006661649 PTPRE ENSG00000132334 28584.02072 0.682834908 0.000257724 0.00673109 KRTCAP3 ENSG00000157992 247.419024 -0.640143207 0.000259109 0.006747951 GNLY ENSG00000115523 21808.78148 -0.989362778 0.000262177 0.006808381 GRIP1 ENSG00000155974 76.49206385 -0.926367374 0.00026751 0.006889649 RP11-701P16.2 ENSG00000251139 52.65436076 1.248093851 0.000267257 0.006889649 TAX1BP1 ENSG00000106052 10167.45189 0.363853367 0.000267062 0.006889649 IGBP1 ENSG00000089289 6106.639031 0.259879111 0.000267574 0.006889649 GDPD1 ENSG00000153982 150.6291611 -0.684407077 0.000268087 0.006893136 PLPP3 ENSG00000162407 79.10183017 1.097389089 0.000271022 0.006944182 ATP6V1E1 ENSG00000131100 5405.398252 0.443798974 0.000275046 0.006994712 POMGNT1 ENSG00000085998 1976.602547 -0.410171244 0.000274406 0.006994712 PTPN1 ENSG00000196396 9420.177793 0.470743233 0.000275892 0.007004891 ZNF74 ENSG00000185252 404.4964917 -0.805117737 0.000278159 0.00704283 ZCCHC6 ENSG00000083223 14745.13688 0.617719308 0.000278625 0.007044856 SELL ENSG00000188404 61071.51112 0.72936318 0.000286362 0.007148304 RP11-863K10.7 ENSG00000183154 73.68338464 0.97247459 0.0002864 0.007148304 RILPL2 ENSG00000150977 7408.976074 0.670124447 0.00028613 0.007148304 DDX21 ENSG00000165732 16218.41367 0.478793464 0.00028703 0.007148304 TNFRSF21 ENSG00000146072 480.9934365 0.976341712 0.000285298 0.007148304 MMP19 ENSG00000123342 139.2471911 1.202856698 0.000288189 0.007150603 ATP5C1 ENSG00000165629 9731.816213 0.257536188 0.000288299 0.007150603 SLC39A11 ENSG00000133195 1765.958809 0.4934119 0.000287599 0.007150603

ASAP1 ENSG00000153317 10322.1098 0.584055281 0.000288716 0.007151221 RDX ENSG00000137710 1483.552571 0.370105785 0.000289415 0.007158799 ETV6 ENSG00000139083 10598.3692 0.444186817 0.000290045 0.007164664 ACADVL ENSG00000072778 14916.29649 0.386773064 0.000293602 0.007232919 C19orf38 ENSG00000214212 8680.304804 0.509416771 0.000296094 0.007284478 FUNDC2 ENSG00000165775 2214.813226 0.442860799 0.000297388 0.007306246 CALCRL ENSG00000064989 317.0316971 0.964777631 0.000302608 0.007375065 YWHAE ENSG00000108953 7203.126684 0.479401298 0.000305067 0.007425053 TMEM255A ENSG00000125355 212.6524622 -0.733391899 0.000306284 0.007444743 CLIP1 ENSG00000130779 7770.789015 0.375905412 0.000310988 0.007538986 WDR90 ENSG00000161996 636.7899201 -0.535070016 0.000312572 0.007567305 ZBTB16 ENSG00000109906 3653.747486 1.298167064 0.000314589 0.007598952 EHMT2 ENSG00000204371 4021.578745 -0.388153028 0.000314712 0.007598952 TUBGCP3 ENSG00000126216 3669.186344 0.294096104 0.000316778 0.007628618 CHTF18 ENSG00000127586 1009.275761 -0.605856987 0.000317939 0.007636394 RBP7 ENSG00000162444 2898.601712 0.807039149 0.000318917 0.007645488 SARDH ENSG00000123453 283.4638345 -0.883891924 0.000319156 0.007645488 CAMK2N1 ENSG00000162545 142.0177238 -0.995368169 0.000320737 0.007663216 ADAM22 ENSG00000008277 391.8983611 -0.573881807 0.000321316 0.007666998 RPN1 ENSG00000163902 12441.71449 0.434196467 0.000325813 0.007754012 FABP5 ENSG00000164687 670.542232 0.780751203 0.000328432 0.007760483 NFKB1 ENSG00000109320 7090.606483 0.297236882 0.000328494 0.007760483 EIF3I ENSG00000084623 7591.58604 0.285823127 0.000327424 0.007760483 IFT172 ENSG00000138002 1302.250113 -0.372026308 0.000328639 0.007760483 AGPS ENSG00000018510 4259.979658 0.449992043 0.000328184 0.007760483 DPY19L3 ENSG00000178904 1692.229453 0.830682191 0.000329793 0.007777661 ZNF365 ENSG00000138311 259.3049052 -0.999441525 0.000332631 0.007806213 ZNF281 ENSG00000162702 3927.40641 0.845538333 0.00033244 0.007806213 PADI4 ENSG00000159339 8565.296555 0.918849586 0.000333343 0.007810841 PSMD7 ENSG00000103035 6938.558001 0.351705028 0.000334387 0.007825268 DNASE1L3 ENSG00000163687 69.44071326 -1.431454042 0.000337631 0.007880939 TOP1 ENSG00000198900 8536.40182 0.551268666 0.000337392 0.007880939 KIF9 ENSG00000088727 157.3157567 0.601576209 0.000339584 0.007906283 DCTN4 ENSG00000132912 6690.5838 0.578311812 0.000340682 0.007921716 OSGEPL1 ENSG00000128694 515.9347886 -0.584196635 0.000342394 0.007951388 SOX13 ENSG00000143842 799.1784756 -0.985330151 0.000345122 0.007974117 GNS ENSG00000135677 23861.92072 0.620572805 0.000344458 0.007974117 CYB5R1 ENSG00000159348 2184.191247 0.310355902 0.000344752 0.007974117 SPIRE2 ENSG00000204991 361.1654573 -0.911327102 0.000347515 0.00801924 PRDX3 ENSG00000165672 5455.345594 0.573359825 0.000350915 0.008067067 YME1L1 ENSG00000136758 11155.39167 0.342449638 0.000353242 0.008110335 ZC4H2 ENSG00000126970 466.8500633 -0.531682743 0.000355079 0.008132023 HEXB ENSG00000049860 9616.803053 0.553896107 0.000358447 0.008180347 FKBP1C ENSG00000198225 621.4826977 0.529501905 0.000358225 0.008180347 RNF166 ENSG00000158717 24881.08188 -0.511555088 0.000359246 0.008186312 TPK1 ENSG00000196511 1433.045993 0.574387384 0.00036081 0.008194799

PTDSS1 ENSG00000156471 6248.849454 0.315650613 0.000367155 0.008304273 BCL3 ENSG00000069399 6724.477508 0.780256782 0.000369463 0.008345816 RAD1 ENSG00000113456 1226.210563 -0.368175166 0.000369908 0.008345816 FAM109B ENSG00000177096 363.7221919 0.56704821 0.000370872 0.008357231 METRN ENSG00000103260 111.7424381 -0.931550334 0.000373022 0.008388135 BICDL1 ENSG00000135127 2498.666587 -0.76523429 0.000379556 0.008489954 PCSK7 ENSG00000160613 15905.58949 -0.40917076 0.000380974 0.008511221 RHEB ENSG00000106615 2311.122163 0.402395086 0.000383827 0.008564472 PLD1 ENSG00000075651 788.2646472 0.873810081 0.000384436 0.008567566 JARID2 ENSG00000008083 10459.1298 0.725260451 0.000390772 0.008687526 SELENOP ENSG00000250722 144.4483647 1.005530372 0.000397797 0.008793818 ADAM10 ENSG00000137845 14157.25561 0.461644225 0.000398152 0.008793818 KIAA0907 ENSG00000132680 6071.361865 -0.368719659 0.000398447 0.008793818 GTF2E2 ENSG00000197265 1575.78556 0.353999197 0.000397251 0.008793818 NOL10 ENSG00000115761 1675.258985 0.344340861 0.000396748 0.008793818 TRIP12 ENSG00000153827 11057.84941 0.42189854 0.000400873 0.008831724 TRIP4 ENSG00000103671 1856.260542 0.297336361 0.000401134 0.008831724 PCTP ENSG00000141179 1840.178389 0.594533895 0.000405016 0.008874329 SLC22A15 ENSG00000163393 4718.707336 0.802459392 0.000410727 0.008956405 ZMYND15 ENSG00000141497 657.9372468 0.684045777 0.000412301 0.008979988 ZMIZ2 ENSG00000122515 11054.57171 -0.343498605 0.000416509 0.009060812 WDCP ENSG00000163026 385.1608812 -0.566503274 0.000419979 0.009125401 AMOT ENSG00000126016 192.7025887 -0.745993048 0.000425684 0.009149252 CCRL2 ENSG00000121797 344.2829466 0.805151929 0.000425028 0.009149252 YBX3 ENSG00000060138 6221.375282 0.596839865 0.000421773 0.009149252 VNN1 ENSG00000112299 2919.276212 1.042880315 0.000424497 0.009149252 SLC9A9 ENSG00000181804 2679.077212 0.462461155 0.000426085 0.009149252 MMP9 ENSG00000100985 4355.401359 1.410129255 0.000425613 0.009149252 BCL2A1 ENSG00000140379 8740.674086 1.015980125 0.000426597 0.009149252 ZCCHC18 ENSG00000166707 169.4174513 -0.639845782 0.00042554 0.009149252 NCOA4 ENSG00000266412 29940.73367 0.606724071 0.000431011 0.009233046 ZNF853 ENSG00000236609 362.0494917 -0.713739325 0.00043218 0.009247229 TBC1D8 ENSG00000204634 5392.006066 0.583288938 0.000436084 0.009298023 PTPN11 ENSG00000179295 6787.153667 0.295308046 0.000445989 0.009473252 FAM110C ENSG00000184731 49.91763795 -1.28834705 0.00045276 0.009578743 METAP2 ENSG00000111142 3923.273486 0.271016955 0.000452928 0.009578743 SCRIB ENSG00000180900 3657.133103 -0.449430123 0.000457612 0.009641129 SIRPA ENSG00000198053 17050.86953 0.730115935 0.00045758 0.009641129 PLXNA3 ENSG00000130827 3160.261318 -0.718673774 0.000458373 0.009641129 FBXO48 ENSG00000204923 356.3872157 -0.523157571 0.000460581 0.009667974 ASAH1 ENSG00000104763 23277.57966 0.610137541 0.000461649 0.009673394 ZNF831 ENSG00000124203 5444.078929 -0.616664433 0.000465286 0.009704995 CAP1 ENSG00000131236 43274.55064 0.454263611 0.000464622 0.009704995 GIPR ENSG00000010310 542.4698537 -0.850140752 0.000464952 0.009704995 FAM193B ENSG00000146067 7693.926989 -0.340283703 0.000466338 0.009712347 SCAP ENSG00000114650 5356.067357 -0.27547742 0.000468963 0.00973713

NCF2 ENSG00000116701 48577.16552 0.653825929 0.000476814 0.009888874 CHST11 ENSG00000171310 7592.81721 0.409339859 0.000479749 0.009915897 VPS54 ENSG00000143952 4586.355491 0.412805368 0.000482387 0.009936619 ENY2 ENSG00000120533 5180.88058 0.320409886 0.000482174 0.009936619 DOCK8 ENSG00000107099 18840.94962 0.470085034 0.000483056 0.009939184 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 8. Significantly differential expressed genes in the comparison of ACLF with NC

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (NC/ACLF) adjustedb

CEBPB ENSG00000172216 8362.569999 3.098357818 3.85E-38 1.11E-33 CXCL16 ENSG00000161921 5231.693471 1.69717783 1.25E-26 1.80E-22 MAFB ENSG00000204103 16465.74714 2.418032169 8.07E-24 7.77E-20 GRINA ENSG00000178719 6074.025191 1.310170256 1.17E-23 8.49E-20 PPARG ENSG00000132170 224.2575813 2.639151468 3.77E-23 2.18E-19 RAB20 ENSG00000139832 2477.197034 1.948770713 1.14E-22 5.48E-19 SYN1 ENSG00000008056 155.6453355 3.100758944 1.18E-21 4.27E-18 PGD ENSG00000142657 31193.53436 1.362097167 1.04E-20 3.01E-17 NOTCH3 ENSG00000074181 168.8039977 2.573177408 1.45E-20 3.80E-17 ST14 ENSG00000149418 4839.983037 1.799369589 2.29E-20 5.51E-17 SEMA6B ENSG00000167680 6915.578366 3.872073007 5.11E-20 1.14E-16 TXNL1 ENSG00000091164 5175.104276 0.581218934 1.24E-19 2.10E-16 CREG1 ENSG00000143162 12184.3935 1.501132547 1.17E-19 2.10E-16 TCN2 ENSG00000185339 3088.927726 2.234225339 1.04E-19 2.10E-16 MERTK ENSG00000153208 2508.228809 2.225228256 1.44E-19 2.23E-16 FBP1 ENSG00000165140 4863.304685 1.59371291 1.46E-19 2.23E-16 MAPRE1 ENSG00000101367 13787.53394 0.560752435 5.70E-19 7.84E-16 MLXIPL ENSG00000009950 34.64679513 3.486688956 1.05E-18 1.32E-15 IL10 ENSG00000136634 294.4748313 3.522276847 1.21E-18 1.46E-15 PDK4 ENSG00000004799 4828.865499 2.401452477 3.27E-18 3.63E-15 ACOX2 ENSG00000168306 67.43426711 2.547544116 3.16E-18 3.63E-15 COPS2 ENSG00000166200 6152.047471 0.81665343 6.77E-18 6.98E-15 AKIRIN2 ENSG00000135334 5877.97278 0.800441418 1.35E-17 1.35E-14 GPER1 ENSG00000164850 383.9326607 2.399465284 1.46E-17 1.41E-14 SDC3 ENSG00000162512 948.2930796 2.035475781 2.29E-17 2.14E-14 DYSF ENSG00000135636 18758.03452 1.572549892 3.53E-17 3.18E-14 HMGB3 ENSG00000029993 692.5488046 1.715050575 3.86E-17 3.38E-14 NOCT ENSG00000151014 766.9630394 2.3049379 4.67E-17 3.97E-14 ADM ENSG00000148926 2984.276553 2.179372552 6.63E-17 5.48E-14 THBS1 ENSG00000137801 59688.98322 3.448862283 9.35E-17 7.32E-14 ARHGAP29 ENSG00000137962 381.8450252 2.309897967 1.24E-16 9.42E-14 PLBD1 ENSG00000121316 37311.02572 1.661413752 1.45E-16 1.08E-13 RIPK2 ENSG00000104312 3871.303815 1.066473785 1.49E-16 1.08E-13 ZNF582 ENSG00000018869 205.7956352 -0.992742392 3.93E-16 2.52E-13 UBIAD1 ENSG00000120942 1682.042646 -0.712001764 4.59E-16 2.88E-13 THEMIS2 ENSG00000130775 28225.87195 1.170476393 4.88E-16 3.00E-13 NFIL3 ENSG00000165030 8149.604197 1.683782769 6.29E-16 3.78E-13 MPP1 ENSG00000130830 6577.202631 1.101995258 8.96E-16 5.26E-13 PPIF ENSG00000108179 7413.373782 1.911608322 9.10E-16 5.26E-13 JDP2 ENSG00000140044 6289.334475 1.994843601 9.86E-16 5.58E-13 C16orf87 ENSG00000155330 1242.193921 0.760817852 1.41E-15 7.84E-13 NLRP3 ENSG00000162711 7675.532978 1.333244753 1.76E-15 9.41E-13

ECHDC3 ENSG00000134463 1080.025068 2.28420575 1.75E-15 9.41E-13 EXT1 ENSG00000182197 2017.001579 0.979628391 2.22E-15 1.17E-12 SOCS6 ENSG00000170677 817.5364197 1.280181317 2.77E-15 1.43E-12 UBE2R2 ENSG00000107341 10218.52622 0.856040825 4.50E-15 2.28E-12 RSL24D1 ENSG00000137876 8720.192075 0.430506902 4.72E-15 2.35E-12 ETS2 ENSG00000157557 14426.06231 1.938393459 5.57E-15 2.69E-12 LAPTM4A ENSG00000068697 9037.443644 0.748212412 5.58E-15 2.69E-12 CHN2 ENSG00000106069 2785.194605 0.848434488 6.42E-15 3.04E-12 THBD ENSG00000178726 2577.197718 2.170548622 7.87E-15 3.61E-12 UPP1 ENSG00000183696 15188.34511 1.282724488 9.89E-15 4.47E-12 P2RY1 ENSG00000169860 1041.156074 2.222681554 1.22E-14 5.35E-12 BCL3 ENSG00000069399 6165.689057 1.42034679 1.37E-14 5.93E-12 YOD1 ENSG00000180667 5371.004868 1.23366008 1.62E-14 6.80E-12 F5 ENSG00000198734 7289.954908 1.451921502 1.61E-14 6.80E-12 CHMP4B ENSG00000101421 12592.75483 0.656027392 1.94E-14 7.78E-12 C15orf40 ENSG00000169609 1066.761586 -0.577580179 2.28E-14 9.04E-12 DDX21 ENSG00000165732 15505.61088 0.855598505 2.53E-14 9.89E-12 APLP2 ENSG00000084234 73742.03099 1.135297073 3.22E-14 1.22E-11 FAM20A ENSG00000108950 778.601825 2.790123466 3.54E-14 1.33E-11 ABCA1 ENSG00000165029 3859.804769 1.88320732 3.64E-14 1.34E-11 SRGN ENSG00000122862 104210.4955 1.267708591 3.66E-14 1.34E-11 UBE2D3 ENSG00000109332 30570.5847 0.497553714 3.95E-14 1.41E-11 TIPARP ENSG00000163659 9032.446972 1.909751135 4.43E-14 1.56E-11 RNF144B ENSG00000137393 12188.48041 1.623527757 4.67E-14 1.60E-11 GNA15 ENSG00000060558 3504.07256 1.275040263 4.85E-14 1.65E-11 DCTN4 ENSG00000132912 6366.994433 0.978666895 5.85E-14 1.97E-11 KCNQ1 ENSG00000053918 3932.747934 0.83951836 6.01E-14 2.00E-11 TMEM223 ENSG00000168569 555.0424866 -0.67575785 6.90E-14 2.27E-11 ADIPOR1 ENSG00000159346 15683.42842 1.009862524 8.32E-14 2.68E-11 DSC2 ENSG00000134755 2001.092066 1.569945346 8.33E-14 2.68E-11 CPT1A ENSG00000110090 10772.46798 0.883171482 9.67E-14 3.07E-11 WDCP ENSG00000163026 516.6025162 -1.082446155 9.89E-14 3.11E-11 YBX3 ENSG00000060138 5801.506844 1.10761981 1.04E-13 3.20E-11 KYNU ENSG00000115919 5016.512704 1.576502802 1.08E-13 3.30E-11 BRI3 ENSG00000164713 6231.32852 1.0340678 1.20E-13 3.61E-11 RHOQ ENSG00000119729 2817.392117 0.954146088 1.35E-13 3.97E-11 ZMYND15 ENSG00000141497 597.0407216 1.365603573 1.47E-13 4.29E-11 TRPV4 ENSG00000111199 305.3476808 1.823781098 1.70E-13 4.86E-11 ZEB2 ENSG00000169554 30810.90225 1.032332666 1.70E-13 4.86E-11 SLC30A1 ENSG00000170385 4640.161148 1.107438001 1.89E-13 5.36E-11 S100A12 ENSG00000163221 22694.15826 1.87883714 2.11E-13 5.86E-11 SERPINB1 ENSG00000021355 28320.38624 1.084002438 2.20E-13 6.05E-11 TDRD9 ENSG00000156414 1480.996476 1.521556481 2.33E-13 6.30E-11 SPOCK1 ENSG00000152377 279.2651492 1.416883533 2.31E-13 6.30E-11 TMEM167A ENSG00000174695 12310.77601 0.858367576 2.44E-13 6.54E-11 UBASH3B ENSG00000154127 3664.778433 0.701712741 2.80E-13 7.43E-11

NCOR2 ENSG00000196498 13379.68568 0.741866982 2.84E-13 7.45E-11 IL16 ENSG00000172349 13925.78677 -0.71976497 3.72E-13 9.61E-11 GPCPD1 ENSG00000125772 28180.80974 0.871113612 4.40E-13 1.12E-10 PRKACA ENSG00000072062 10782.83743 0.812946287 4.56E-13 1.15E-10 WASL ENSG00000106299 1104.32546 0.890493132 5.35E-13 1.32E-10 VSIG4 ENSG00000155659 3461.320787 2.942285654 5.34E-13 1.32E-10 IRAK3 ENSG00000090376 12169.49457 1.534753827 5.74E-13 1.37E-10 ZNF74 ENSG00000185252 559.4647026 -1.330399087 5.72E-13 1.37E-10 LRP1 ENSG00000123384 58668.78332 1.171959673 5.70E-13 1.37E-10 ENY2 ENSG00000120533 5130.177482 0.543128753 6.18E-13 1.46E-10 ZNF385A ENSG00000161642 9642.047666 0.958926769 6.88E-13 1.60E-10 CTD-2267D19.3 ENSG00000266208 155.3467342 1.209837289 6.99E-13 1.61E-10 VIM ENSG00000026025 157367.2474 1.075533083 7.17E-13 1.64E-10 SOCS3 ENSG00000184557 11393.63675 1.735049692 7.55E-13 1.72E-10 SERTAD2 ENSG00000179833 8603.34137 1.047266762 8.34E-13 1.88E-10 F12 ENSG00000131187 219.9767223 1.510578554 8.47E-13 1.90E-10 SH2B2 ENSG00000160999 956.5966699 0.950320427 9.35E-13 2.06E-10 TWF1 ENSG00000151239 5042.198394 0.678440262 9.44E-13 2.07E-10 SLC9A9 ENSG00000181804 2655.122696 0.668535681 1.01E-12 2.18E-10 POMP ENSG00000132963 4783.187289 0.556349023 1.30E-12 2.78E-10 SDC4 ENSG00000124145 590.8331716 2.281343856 1.32E-12 2.80E-10 TGM2 ENSG00000198959 1137.271538 2.325731498 1.36E-12 2.84E-10 SOCS1 ENSG00000185338 268.4511286 1.684169084 1.42E-12 2.96E-10 LAPTM5 ENSG00000162511 174953.8347 0.726782749 1.44E-12 2.96E-10 PLCE1 ENSG00000138193 276.2297216 -1.023283014 1.49E-12 3.03E-10 SMIM3 ENSG00000256235 2385.649669 1.458794595 1.72E-12 3.45E-10 DENND1A ENSG00000119522 5870.173586 0.769941844 1.95E-12 3.85E-10 TMEM160 ENSG00000130748 370.4346967 1.023474526 2.09E-12 4.08E-10 HMOX1 ENSG00000100292 10867.9762 1.272949412 2.11E-12 4.08E-10 HLX ENSG00000136630 1855.920131 1.350141913 2.56E-12 4.89E-10 MYO7A ENSG00000137474 1467.19884 1.976681736 2.60E-12 4.91E-10 PXMP4 ENSG00000101417 590.2739458 -0.831473484 2.60E-12 4.91E-10 SMPDL3A ENSG00000172594 1528.96087 1.235661952 2.70E-12 5.03E-10 SMARCD3 ENSG00000082014 4623.914978 0.926494468 2.78E-12 5.16E-10 SLCO2B1 ENSG00000137491 44.05796299 2.723685225 2.89E-12 5.32E-10 CTSA ENSG00000064601 16220.39848 0.884221946 3.04E-12 5.53E-10 CNTLN ENSG00000044459 883.31045 1.222759049 3.16E-12 5.68E-10 AMIGO1 ENSG00000181754 1023.564564 -1.121059811 4.17E-12 7.44E-10 JRKL ENSG00000183340 738.5896857 -1.197029016 4.51E-12 8.00E-10 GADD45A ENSG00000116717 1382.969713 1.417656886 4.77E-12 8.40E-10 NCSTN ENSG00000162736 13468.12812 0.587743478 4.90E-12 8.59E-10 PLD1 ENSG00000075651 93.35634214 1.68327378 5.05E-12 8.78E-10 CES1 ENSG00000198848 5517.165462 1.966944347 5.18E-12 8.86E-10 OSGEPL1 ENSG00000128694 647.1935343 -0.938142246 5.25E-12 8.93E-10 MAPK6 ENSG00000069956 3338.596315 0.939134106 5.95E-12 9.89E-10 DAP ENSG00000112977 6315.26409 0.573328956 5.99E-12 9.89E-10

ARRB2 ENSG00000141480 39713.87567 0.702726981 6.21E-12 1.02E-09 FOXO3 ENSG00000118689 9747.096966 1.341235695 6.31E-12 1.03E-09 PABPC1 ENSG00000070756 95481.57136 0.413544116 6.45E-12 1.05E-09 BCOR ENSG00000183337 3184.700516 -0.790673041 6.65E-12 1.07E-09 S100A9 ENSG00000163220 315031.0534 1.408195824 7.23E-12 1.15E-09 VCAN ENSG00000038427 80684.68929 1.264994138 7.65E-12 1.20E-09 TIMP1 ENSG00000102265 13402.82821 1.61092019 9.16E-12 1.42E-09 MS4A4A ENSG00000110079 1063.680154 1.771731759 9.70E-12 1.49E-09 PELI2 ENSG00000139946 5180.752975 0.969153425 9.88E-12 1.51E-09 C5AR1 ENSG00000197405 20959.49033 1.306405532 1.02E-11 1.54E-09 CERS6 ENSG00000172292 4812.116219 0.76992388 1.02E-11 1.55E-09 SAMSN1 ENSG00000155307 11858.6931 1.533509095 1.10E-11 1.66E-09 LPCAT3 ENSG00000111684 3057.512186 0.623487362 1.12E-11 1.67E-09 JADE2 ENSG00000043143 7308.08171 -1.053242155 1.17E-11 1.74E-09 XXYLT1 ENSG00000173950 1574.899811 0.908081311 1.21E-11 1.80E-09 EPB41L3 ENSG00000082397 4883.609144 1.167020465 1.29E-11 1.90E-09 SMNDC1 ENSG00000119953 3869.07113 0.660756912 1.38E-11 2.01E-09 MBD2 ENSG00000134046 12361.98029 0.633092043 1.41E-11 2.05E-09 SMCO4 ENSG00000166002 1607.796312 1.046564379 1.63E-11 2.32E-09 ST6GALNAC3 ENSG00000184005 863.604013 1.725975358 1.63E-11 2.32E-09 ICAM1 ENSG00000090339 6359.622721 1.379865888 1.65E-11 2.34E-09 MSRB2 ENSG00000148450 1174.031058 0.962064173 1.66E-11 2.34E-09 ENO2 ENSG00000111674 2583.166926 -1.034435549 1.80E-11 2.52E-09 MARCH9 ENSG00000139266 2054.735518 -0.830253444 1.89E-11 2.63E-09 ZNF234 ENSG00000263002 739.3566204 -1.109251677 2.22E-11 3.06E-09 BCAT1 ENSG00000060982 1427.063599 1.710062341 2.28E-11 3.13E-09 TBXAS1 ENSG00000059377 15988.75201 1.015472486 2.43E-11 3.29E-09 GAS7 ENSG00000007237 19680.06724 1.158926318 2.54E-11 3.42E-09 TFAP2E ENSG00000116819 1243.84034 -0.766541322 2.77E-11 3.69E-09 LBH ENSG00000213626 9933.37765 -1.28746395 3.15E-11 4.11E-09 DNAH17 ENSG00000187775 2840.771098 1.178965039 3.34E-11 4.35E-09 VDAC2 ENSG00000165637 5187.679967 0.490271726 3.71E-11 4.80E-09 TNFRSF12A ENSG00000006327 253.6003202 1.951118842 3.74E-11 4.81E-09 PSMD7 ENSG00000103035 6999.033487 0.48988596 4.08E-11 5.21E-09 ELL2 ENSG00000118985 3471.922964 1.405078414 4.29E-11 5.43E-09 QSOX1 ENSG00000116260 8217.068735 0.968734065 4.34E-11 5.48E-09 ADAM9 ENSG00000168615 2800.581134 1.196064474 4.44E-11 5.55E-09 ZNF470 ENSG00000197016 280.1930785 -1.201468645 4.85E-11 5.98E-09 TRAPPC9 ENSG00000167632 2508.645006 0.360348066 5.34E-11 6.51E-09 SDE2 ENSG00000143751 3513.751583 0.859229766 5.32E-11 6.51E-09 ZFAND3 ENSG00000156639 7638.750256 0.666446544 5.75E-11 6.95E-09 SCPEP1 ENSG00000121064 13069.59128 0.871029747 5.74E-11 6.95E-09 ZNF473 ENSG00000142528 908.2667717 -0.694356147 5.95E-11 7.16E-09 GRASP ENSG00000161835 5687.823673 1.889576205 6.20E-11 7.41E-09 GYG1 ENSG00000163754 5646.690807 0.899574136 7.27E-11 8.50E-09 MMGT1 ENSG00000169446 3752.685932 0.506102708 7.19E-11 8.50E-09

PTP4A1 ENSG00000112245 8861.656815 0.648286653 7.16E-11 8.50E-09 PLEKHG3 ENSG00000126822 5855.228178 -0.887544974 7.25E-11 8.50E-09 ITGAM ENSG00000169896 41400.93056 0.860685966 7.48E-11 8.72E-09 CD36 ENSG00000135218 26169.07098 1.42624083 7.76E-11 9.01E-09 TOM1 ENSG00000100284 10084.98322 1.02644537 8.09E-11 9.34E-09 ZMIZ1 ENSG00000108175 13413.0611 0.883345429 8.16E-11 9.37E-09 GDF11 ENSG00000135414 1008.714013 -0.968850827 8.17E-11 9.37E-09 LDHA ENSG00000134333 21426.20005 0.723452499 8.28E-11 9.46E-09 MYO10 ENSG00000145555 193.2505804 1.370053771 8.35E-11 9.50E-09 H2AFY ENSG00000113648 25520.70905 0.876342192 8.61E-11 9.72E-09 CD93 ENSG00000125810 27017.8377 1.124688717 8.82E-11 9.88E-09 ZKSCAN3 ENSG00000189298 476.8363112 -1.0089213 1.02E-10 1.13E-08 SMAP1 ENSG00000112305 3369.20822 0.478194683 1.02E-10 1.13E-08 BBS10 ENSG00000179941 573.9060528 -0.96900868 1.06E-10 1.16E-08 CHIC2 ENSG00000109220 2890.420428 0.944905089 1.07E-10 1.17E-08 TKT ENSG00000163931 50597.89583 0.832405218 1.25E-10 1.33E-08 MSR1 ENSG00000038945 1539.959022 1.638710526 1.26E-10 1.33E-08 VPS54 ENSG00000143952 4544.100333 0.623079659 1.28E-10 1.34E-08 MAFF ENSG00000185022 2016.305354 1.773769543 1.29E-10 1.34E-08 CMIP ENSG00000153815 9503.082065 0.699229831 1.34E-10 1.40E-08 SLA ENSG00000155926 24953.02269 1.620242922 1.37E-10 1.42E-08 KLHL2 ENSG00000109466 5190.625926 1.066761613 1.40E-10 1.45E-08 NECTIN2 ENSG00000130202 660.5406932 1.446198231 1.41E-10 1.45E-08 DEGS2 ENSG00000168350 42.06678082 -1.852491147 1.55E-10 1.58E-08 C19orf38 ENSG00000214212 8388.949756 0.827771644 1.57E-10 1.60E-08 NR4A3 ENSG00000119508 342.1253334 2.262417209 1.62E-10 1.64E-08 SORCS2 ENSG00000184985 573.2914955 1.380340479 1.69E-10 1.70E-08 BLOC1S2 ENSG00000196072 3309.146376 0.670290373 1.77E-10 1.78E-08 SAP30 ENSG00000164105 2885.768805 1.738384164 1.88E-10 1.85E-08 PEX11A ENSG00000166821 117.5715684 -0.993756602 2.08E-10 2.03E-08 FN1 ENSG00000115414 640.2663131 2.135659959 2.18E-10 2.11E-08 TTYH3 ENSG00000136295 10109.63494 0.986584771 2.19E-10 2.12E-08 HERPUD1 ENSG00000051108 10176.043 0.895455893 2.22E-10 2.14E-08 AREG ENSG00000109321 2633.459892 2.453001057 2.28E-10 2.18E-08 PLSCR1 ENSG00000188313 8497.290572 1.140296918 2.64E-10 2.49E-08 KLF9 ENSG00000119138 11581.26968 1.512819958 2.66E-10 2.50E-08 CTD-2547L24.3 ENSG00000258875 550.0782591 -1.048433349 2.87E-10 2.67E-08 CEP89 ENSG00000121289 971.9558787 -0.812373146 2.88E-10 2.68E-08 G6PD ENSG00000160211 9052.118731 0.713974378 2.93E-10 2.71E-08 SDCBP ENSG00000137575 16263.5796 1.147887296 3.13E-10 2.87E-08 KCNE1 ENSG00000180509 1316.162187 1.528779596 3.22E-10 2.95E-08 BRD8 ENSG00000112983 3180.312015 -0.527172951 3.46E-10 3.11E-08 LSS ENSG00000160285 2973.832439 -0.747053524 3.45E-10 3.11E-08 CCNY ENSG00000108100 12816.126 0.623898021 3.52E-10 3.16E-08 RP11-403I13.8 ENSG00000272419 2701.408172 -0.715401428 3.55E-10 3.18E-08 ASAH1 ENSG00000104763 22272.54601 0.977183891 3.62E-10 3.22E-08

MMACHC ENSG00000132763 202.4228325 -1.128233273 3.63E-10 3.22E-08 MAP1LC3B ENSG00000140941 4039.121472 1.032376573 3.70E-10 3.28E-08 ITGA9 ENSG00000144668 395.5006792 2.003662407 3.78E-10 3.34E-08 C1orf74 ENSG00000162757 856.8783658 -1.309964712 3.87E-10 3.40E-08 ETV6 ENSG00000139083 10471.24961 0.662868399 3.91E-10 3.41E-08 LGALS3 ENSG00000131981 9972.283677 0.909340646 3.91E-10 3.41E-08 PLAA ENSG00000137055 2936.399874 0.639829183 4.01E-10 3.47E-08 C4orf48 ENSG00000243449 88.37345009 2.175655732 4.15E-10 3.57E-08 DNTTIP2 ENSG00000067334 5916.075864 0.713654875 4.19E-10 3.59E-08 TNFAIP3 ENSG00000118503 41344.01587 1.474064261 4.42E-10 3.75E-08 STX11 ENSG00000135604 15275.8373 1.02020279 4.74E-10 3.99E-08 USP3 ENSG00000140455 16343.56322 0.601561446 5.01E-10 4.21E-08 SLC36A4 ENSG00000180773 2758.015121 1.016252427 5.05E-10 4.23E-08 MIDN ENSG00000167470 15346.72228 0.930993166 5.72E-10 4.76E-08 COTL1 ENSG00000103187 78920.13997 0.816444028 5.86E-10 4.87E-08 CDIP1 ENSG00000089486 1883.284143 -0.742065593 6.21E-10 5.14E-08 TPST1 ENSG00000169902 1105.555844 2.039195764 6.34E-10 5.21E-08 DAPK1 ENSG00000196730 10171.25826 0.974946326 6.59E-10 5.36E-08 GRK3 ENSG00000100077 6441.163114 0.813154124 6.64E-10 5.39E-08 FANCF ENSG00000183161 829.7346574 -0.738487649 6.77E-10 5.48E-08 RIN3 ENSG00000100599 16520.12992 0.756269446 6.92E-10 5.59E-08 CTSB ENSG00000164733 41885.43413 1.298232147 7.40E-10 5.90E-08 COPA ENSG00000122218 16131.68902 0.466293847 8.08E-10 6.43E-08 FGR ENSG00000000938 74771.02949 0.703390809 8.36E-10 6.61E-08 GRPEL1 ENSG00000109519 2811.886575 0.842119824 8.38E-10 6.61E-08 P3H4 ENSG00000141696 185.5777332 -1.152684789 9.28E-10 7.28E-08 LIN7A ENSG00000111052 2721.392526 1.315542695 9.56E-10 7.49E-08 AGPAT2 ENSG00000169692 2228.749506 0.889592314 1.01E-09 7.88E-08 GIN1 ENSG00000145723 442.7613691 -1.024040239 1.06E-09 8.24E-08 MRPL44 ENSG00000135900 2582.6089 0.543092517 1.07E-09 8.31E-08 FBXO48 ENSG00000204923 441.0175402 -0.854202203 1.11E-09 8.58E-08 CD63 ENSG00000135404 12818.8836 0.946295566 1.14E-09 8.70E-08 GLUL ENSG00000135821 46683.61527 1.057990355 1.14E-09 8.74E-08 FTL ENSG00000087086 276407.6214 0.966305379 1.15E-09 8.74E-08 RAPGEF2 ENSG00000109756 4917.877879 0.949279454 1.22E-09 9.26E-08 BCL10 ENSG00000142867 2094.10272 0.790765624 1.33E-09 1.00E-07 UBE2E1 ENSG00000170142 6806.14869 0.498998837 1.37E-09 1.03E-07 C10orf11 ENSG00000148655 356.072958 0.951257694 1.42E-09 1.06E-07 DDIT4 ENSG00000168209 14613.8731 1.673529507 1.43E-09 1.07E-07 THEM6 ENSG00000130193 553.8050121 -0.912575914 1.44E-09 1.07E-07 GAPDH ENSG00000111640 129417.7478 0.732840133 1.46E-09 1.08E-07 EAF1 ENSG00000144597 1984.616745 1.236082341 1.48E-09 1.09E-07 SEC62 ENSG00000008952 5715.265512 0.871153282 1.52E-09 1.11E-07 RAB34 ENSG00000109113 1386.267081 0.834107225 1.54E-09 1.12E-07 WNT5A ENSG00000114251 31.17763872 2.675223068 1.60E-09 1.16E-07 GALC ENSG00000054983 5110.062524 0.669588048 1.62E-09 1.17E-07

STAB1 ENSG00000010327 27267.66526 1.319347737 1.72E-09 1.23E-07 ARHGAP24 ENSG00000138639 2178.048571 1.326209452 1.72E-09 1.23E-07 SYAP1 ENSG00000169895 5001.485034 1.044498253 1.71E-09 1.23E-07 CD40LG ENSG00000102245 1843.442591 -1.172764909 1.72E-09 1.23E-07 TMEM39A ENSG00000176142 3131.865017 0.804885515 1.84E-09 1.31E-07 PTPRE ENSG00000132334 27831.99871 0.953152242 1.91E-09 1.35E-07 DNAJB12 ENSG00000148719 4363.80866 0.64204491 2.01E-09 1.41E-07 GAREM1 ENSG00000141441 59.38243896 1.266053894 2.12E-09 1.48E-07 DMXL2 ENSG00000104093 17290.89672 0.9529214 2.16E-09 1.50E-07 SOWAHC ENSG00000198142 349.23026 1.304414973 2.21E-09 1.53E-07 TBC1D8 ENSG00000204634 5123.939711 0.981340912 2.23E-09 1.53E-07 IFNGR1 ENSG00000027697 22389.14722 1.21152129 2.23E-09 1.53E-07 C1QB ENSG00000173369 952.9483075 1.927105215 2.27E-09 1.56E-07 RBP4 ENSG00000138207 7.915593257 2.765153367 2.28E-09 1.56E-07 RTKN ENSG00000114993 80.82778112 -1.133179765 2.30E-09 1.56E-07 CHST11 ENSG00000171310 7554.992876 0.599830105 2.30E-09 1.56E-07 AC013461.1 ENSG00000091436 2604.873362 0.888481421 2.38E-09 1.62E-07 GPR84 ENSG00000139572 199.8893303 1.509814832 2.40E-09 1.63E-07 CTNNB1 ENSG00000168036 14164.91619 0.604886968 2.51E-09 1.69E-07 ARL8A ENSG00000143862 5969.224134 0.759003295 2.58E-09 1.73E-07 SEMA4A ENSG00000196189 8674.791249 0.746574366 2.66E-09 1.79E-07 PTGES ENSG00000148344 177.1192157 2.155520267 2.69E-09 1.79E-07 RIT1 ENSG00000143622 5500.681529 1.023260674 2.68E-09 1.79E-07 YBX1 ENSG00000065978 38151.46421 0.535177953 2.89E-09 1.90E-07 WDR59 ENSG00000103091 3260.397216 -0.38176887 2.93E-09 1.92E-07 AGTPBP1 ENSG00000135049 17379.29399 0.717266449 3.06E-09 1.99E-07 MTMR3 ENSG00000100330 10809.35953 0.808035629 3.08E-09 2.00E-07 MVK ENSG00000110921 566.4034528 -0.75618252 3.12E-09 2.03E-07 CD1D ENSG00000158473 6600.936716 0.910840893 3.28E-09 2.13E-07 NPRL2 ENSG00000114388 2063.194146 -0.612510243 3.37E-09 2.17E-07 ALDH3B1 ENSG00000006534 4440.414746 0.920592415 3.53E-09 2.27E-07 INSR ENSG00000171105 1980.751961 0.948798785 3.74E-09 2.39E-07 CEP170 ENSG00000143702 4549.150935 0.795419207 3.93E-09 2.50E-07 ACSL3 ENSG00000123983 3118.861937 0.72410517 4.11E-09 2.60E-07 PIGA ENSG00000165195 2766.511116 0.683995237 4.17E-09 2.62E-07 SLCO4A1 ENSG00000101187 164.5432054 1.826587653 4.18E-09 2.62E-07 PICALM ENSG00000073921 26062.11885 0.724739953 4.18E-09 2.62E-07 SP3 ENSG00000172845 12032.11638 0.753294775 4.34E-09 2.70E-07 DIAPH2 ENSG00000147202 2790.007873 0.730425155 4.34E-09 2.70E-07 THEM5 ENSG00000196407 820.4319598 -0.958191552 4.37E-09 2.71E-07 MTHFD2 ENSG00000065911 3857.223689 0.770152831 4.64E-09 2.85E-07 GIMAP7 ENSG00000179144 6124.854085 -1.423017095 4.72E-09 2.89E-07 MBLAC2 ENSG00000176055 626.3901445 -0.667367233 4.83E-09 2.94E-07 WASF1 ENSG00000112290 333.6210235 1.059885182 5.08E-09 3.07E-07 TKTL2 ENSG00000151005 66.1048563 2.252954346 5.12E-09 3.09E-07 TBC1D10C ENSG00000175463 14306.0601 -0.724420194 5.13E-09 3.10E-07

GPNMB ENSG00000136235 232.5542814 1.751459957 5.26E-09 3.16E-07 TRAF3IP3 ENSG00000009790 28748.24347 -0.609212274 5.49E-09 3.28E-07 FGD4 ENSG00000139132 4352.782199 1.299405891 5.64E-09 3.36E-07 FAM198B ENSG00000164125 9753.142951 1.30909359 5.75E-09 3.40E-07 DBP ENSG00000105516 853.4990755 -0.826431865 5.76E-09 3.40E-07 LIMA1 ENSG00000050405 981.8157616 -0.886813821 5.83E-09 3.42E-07 CFP ENSG00000126759 19918.80771 0.877575698 6.09E-09 3.57E-07 CLIC4 ENSG00000169504 4170.437447 0.838295767 6.17E-09 3.61E-07 LLGL1 ENSG00000131899 1995.351288 -0.465236825 6.40E-09 3.71E-07 TXNL4A ENSG00000141759 2781.437489 0.404463341 6.39E-09 3.71E-07 MAP3K8 ENSG00000107968 6108.336379 0.893484293 6.48E-09 3.75E-07 CRELD1 ENSG00000163703 1527.624885 -0.714706069 6.63E-09 3.83E-07 ANO10 ENSG00000160746 1370.958478 0.816648273 6.72E-09 3.87E-07 ZMYM3 ENSG00000147130 2747.009925 -0.50562249 6.87E-09 3.93E-07 ZFAND5 ENSG00000107372 23500.54125 0.896677125 6.92E-09 3.94E-07 CYB5R2 ENSG00000166394 114.1989281 1.491074336 6.91E-09 3.94E-07 FKBP5 ENSG00000096060 19522.15424 1.258130899 7.04E-09 4.00E-07 KMT5A ENSG00000183955 3298.261602 0.592863495 7.34E-09 4.17E-07 KIF3A ENSG00000131437 949.95518 -0.790012042 7.37E-09 4.18E-07 AGAP2 ENSG00000135439 3771.400661 -0.620636093 7.61E-09 4.30E-07 UBE2D1 ENSG00000072401 6099.595963 0.923552465 7.72E-09 4.35E-07 TNFRSF21 ENSG00000146072 449.1842389 1.491300464 7.98E-09 4.48E-07 SIL1 ENSG00000120725 1610.705961 0.664091477 8.29E-09 4.65E-07 ZNF550 ENSG00000251369 1453.262808 -0.732327409 8.47E-09 4.74E-07 P2RX4 ENSG00000135124 3669.921114 0.661929923 8.87E-09 4.94E-07 SPRY2 ENSG00000136158 260.2016564 1.733740445 8.95E-09 4.98E-07 SMAD1 ENSG00000170365 454.8712762 1.114998861 9.78E-09 5.40E-07 C3orf18 ENSG00000088543 621.8871735 -0.879327121 1.01E-08 5.53E-07 S100A8 ENSG00000143546 101585.6565 1.318786728 1.02E-08 5.59E-07 GUSB ENSG00000169919 6062.312629 0.561228449 1.02E-08 5.60E-07 CPD ENSG00000108582 11686.24547 0.961890562 1.07E-08 5.84E-07 FAM89A ENSG00000182118 262.6515463 1.205688535 1.08E-08 5.85E-07 TMEM167B ENSG00000215717 8319.518769 0.808304106 1.09E-08 5.91E-07 MED13L ENSG00000123066 13048.30374 1.218502453 1.19E-08 6.39E-07 TTC22 ENSG00000006555 1061.419695 -1.196945492 1.22E-08 6.51E-07 ZNF281 ENSG00000162702 3792.421018 1.157269181 1.26E-08 6.73E-07 PCMTD2 ENSG00000203880 8424.638382 -0.340566497 1.29E-08 6.86E-07 MFSD14A ENSG00000156875 6813.678601 0.588389749 1.32E-08 6.95E-07 OGFOD1 ENSG00000087263 1639.851187 -0.649604365 1.32E-08 6.95E-07 PSMC1 ENSG00000100764 6124.211131 0.425023265 1.35E-08 7.11E-07 MAP2K1 ENSG00000169032 7983.555617 0.602464842 1.39E-08 7.28E-07 C10orf128 ENSG00000204161 1199.60937 -1.183929204 1.39E-08 7.28E-07 FAM49B ENSG00000153310 17871.07006 0.545034073 1.40E-08 7.32E-07 RBM47 ENSG00000163694 5546.820256 0.967508245 1.41E-08 7.34E-07 BUD31 ENSG00000106245 3379.812886 0.476820745 1.42E-08 7.41E-07 RNASE2 ENSG00000169385 5591.562343 1.75587522 1.43E-08 7.42E-07

SLC26A11 ENSG00000181045 2146.304302 -0.786234444 1.43E-08 7.44E-07 KRI1 ENSG00000129347 5015.136943 -0.554203174 1.44E-08 7.44E-07 EVI5 ENSG00000067208 2178.350824 0.815573145 1.44E-08 7.44E-07 BAG4 ENSG00000156735 1267.949951 0.709094785 1.44E-08 7.44E-07 ZFP3 ENSG00000180787 1093.745819 -0.715000306 1.47E-08 7.56E-07 HINFP ENSG00000172273 1944.48705 -0.491067021 1.49E-08 7.61E-07 LPAR5 ENSG00000184574 442.0655333 -1.015613992 1.54E-08 7.85E-07 PSAP ENSG00000197746 260340.6735 0.697332763 1.57E-08 7.98E-07 UBTD1 ENSG00000165886 664.1351495 1.005487987 1.59E-08 8.05E-07 R3HCC1L ENSG00000166024 3766.481325 0.486658132 1.66E-08 8.36E-07 SLC29A2 ENSG00000174669 497.6962833 -0.968878907 1.68E-08 8.41E-07 ABCD1 ENSG00000101986 3013.317983 0.505508217 1.70E-08 8.51E-07 SNIP1 ENSG00000163877 2563.843916 0.878415859 1.71E-08 8.55E-07 NINJ1 ENSG00000131669 11907.30102 1.379226779 1.73E-08 8.63E-07 SYF2 ENSG00000117614 7264.260234 0.519558463 1.74E-08 8.65E-07 HADHB ENSG00000138029 10864.42922 0.571583534 1.91E-08 9.45E-07 RAB13 ENSG00000143545 822.6369722 1.507406025 2.04E-08 9.99E-07 GTF2F1 ENSG00000125651 5507.900846 0.3862211 2.03E-08 9.99E-07 GRB10 ENSG00000106070 1905.262303 1.618324085 2.05E-08 1.00E-06 CSDE1 ENSG00000009307 42532.80969 0.331223179 2.07E-08 1.01E-06 ALDOC ENSG00000109107 1118.700906 -0.713206557 2.11E-08 1.03E-06 AMFR ENSG00000159461 4407.609198 0.416665608 2.12E-08 1.03E-06 CSGALNACT2 ENSG00000169826 22977.99793 1.001729728 2.18E-08 1.06E-06 CHST15 ENSG00000182022 15614.24002 1.001396807 2.27E-08 1.10E-06 PPP1R15B ENSG00000158615 15598.29269 0.644738349 2.27E-08 1.10E-06 CISH ENSG00000114737 1341.967827 -1.235721787 2.29E-08 1.10E-06 ZNF436 ENSG00000125945 841.1346394 -0.568683494 2.32E-08 1.12E-06 BCS1L ENSG00000074582 1034.482891 -0.734605867 2.34E-08 1.12E-06 ACADVL ENSG00000072778 15081.84135 0.509178687 2.37E-08 1.13E-06 FCN1 ENSG00000085265 115685.759 0.889683593 2.39E-08 1.14E-06 YPEL5 ENSG00000119801 20705.48477 0.768326821 2.42E-08 1.15E-06 CYP2U1 ENSG00000155016 616.0951838 -0.71872223 2.42E-08 1.15E-06 STK32B ENSG00000152953 151.0311261 1.053823031 2.43E-08 1.15E-06 RBBP8 ENSG00000101773 1412.737063 0.75298556 2.56E-08 1.21E-06 ITPRIP ENSG00000148841 8452.321081 1.288163196 2.57E-08 1.21E-06 ZNF568 ENSG00000198453 525.4206755 -0.771528687 2.69E-08 1.26E-06 SLC16A6 ENSG00000108932 3730.138445 1.109324616 2.71E-08 1.27E-06 CCIN ENSG00000185972 53.07559341 1.590117673 2.73E-08 1.28E-06 SMAP2 ENSG00000084070 57340.20009 0.851890801 2.78E-08 1.30E-06 ZNF501 ENSG00000186446 101.7851992 -1.199355781 2.82E-08 1.31E-06 TEF ENSG00000167074 558.501355 -0.923090967 2.84E-08 1.32E-06 DLG4 ENSG00000132535 2461.076506 0.716950486 2.85E-08 1.32E-06 UGGT2 ENSG00000102595 522.6234748 1.034731895 2.98E-08 1.38E-06 ENDOD1 ENSG00000149218 1546.176274 -0.729027353 3.01E-08 1.38E-06 CCDC65 ENSG00000139537 678.7993906 -1.122882717 3.03E-08 1.39E-06 TMEM183A ENSG00000163444 5875.217882 0.40734607 3.09E-08 1.41E-06

DLC1 ENSG00000164741 115.0047245 1.426001129 3.22E-08 1.47E-06 MRAS ENSG00000158186 422.2409351 1.288792434 3.23E-08 1.47E-06 GMDS ENSG00000112699 1081.162731 0.491344492 3.33E-08 1.51E-06 LMBRD1 ENSG00000168216 5524.664555 0.54917753 3.43E-08 1.55E-06 RNF130 ENSG00000113269 20475.10844 0.739410168 3.43E-08 1.55E-06 TLE3 ENSG00000140332 8326.748265 0.858249939 3.49E-08 1.57E-06 FTH1 ENSG00000167996 125424.2734 0.77668045 3.50E-08 1.57E-06 ZSWIM6 ENSG00000130449 4845.665341 0.848605729 3.53E-08 1.58E-06 TM9SF2 ENSG00000125304 18676.1292 0.565440641 3.68E-08 1.64E-06 ZBTB47 ENSG00000114853 1067.814336 0.931720707 3.95E-08 1.75E-06 GID8 ENSG00000101193 5886.957389 0.348755082 4.04E-08 1.79E-06 DVL3 ENSG00000161202 7040.03675 0.314303727 4.17E-08 1.83E-06 LYN ENSG00000254087 27675.50708 0.761193481 4.22E-08 1.85E-06 NOG ENSG00000183691 159.2606438 -1.90878136 4.31E-08 1.88E-06 FBXW7 ENSG00000109670 6409.253136 0.481310948 4.34E-08 1.89E-06 MRFAP1L1 ENSG00000178988 4344.677634 -0.793118067 4.42E-08 1.92E-06 IMPA2 ENSG00000141401 2808.758228 0.888262074 4.43E-08 1.92E-06 XRN2 ENSG00000088930 14128.82332 0.491657735 4.44E-08 1.93E-06 PDGFB ENSG00000100311 296.1005276 -1.524568427 4.62E-08 2.00E-06 HGH1 ENSG00000235173 375.6051458 -0.945658918 4.71E-08 2.04E-06 HIPK2 ENSG00000064393 11068.80089 0.801063332 4.73E-08 2.04E-06 NAMPT ENSG00000105835 90648.20636 1.63335162 4.78E-08 2.06E-06 MEF2A ENSG00000068305 7776.897505 1.002486615 4.95E-08 2.12E-06 AGFG2 ENSG00000106351 945.4494517 -0.904886264 5.03E-08 2.15E-06 B3GNT5 ENSG00000176597 1932.299089 1.370721667 5.07E-08 2.16E-06 TPP1 ENSG00000166340 34760.04285 0.65397347 5.13E-08 2.18E-06 ADAMTS1 ENSG00000154734 225.9631141 -1.828462249 5.12E-08 2.18E-06 EDNRB ENSG00000136160 55.92997566 1.980436891 5.30E-08 2.24E-06 TIGD7 ENSG00000140993 645.7361854 -0.799339212 5.30E-08 2.24E-06 HNRNPK ENSG00000165119 49111.53266 0.252204346 5.35E-08 2.25E-06 SPTAN1 ENSG00000197694 18409.55654 -0.481495924 5.46E-08 2.30E-06 FAM200A ENSG00000221909 318.7773639 -0.906387382 5.49E-08 2.30E-06 HEXIM1 ENSG00000186834 5356.709902 -0.354802692 5.54E-08 2.32E-06 SYTL1 ENSG00000142765 7417.307189 -0.641533401 5.60E-08 2.34E-06 ACYP1 ENSG00000119640 725.5311894 -0.867372583 5.70E-08 2.37E-06 MAT2B ENSG00000038274 8388.546167 -0.557967415 5.76E-08 2.39E-06 CPVL ENSG00000106066 27258.75227 0.834955668 5.82E-08 2.41E-06 RGS1 ENSG00000090104 2834.619959 1.50163915 5.85E-08 2.43E-06 JARID2 ENSG00000008083 10247.90126 0.957554936 5.95E-08 2.46E-06 DLEC1 ENSG00000008226 594.6380083 -0.734580738 5.97E-08 2.46E-06 RPA1 ENSG00000132383 5776.768998 -0.426750306 6.13E-08 2.52E-06 TAS2R4 ENSG00000127364 127.3516719 -1.300915554 6.17E-08 2.53E-06 MUM1 ENSG00000160953 1822.086609 -0.521831048 6.25E-08 2.56E-06 PGAM1 ENSG00000171314 13766.68555 0.630241773 6.37E-08 2.60E-06 PRMT7 ENSG00000132600 2474.10816 -0.580504992 6.54E-08 2.65E-06 HRH2 ENSG00000113749 8630.341529 0.980497451 6.58E-08 2.67E-06

CTSZ ENSG00000101160 36469.44822 0.74340763 6.76E-08 2.73E-06 ETF1 ENSG00000120705 7825.213217 0.807288595 7.00E-08 2.82E-06 KIAA1958 ENSG00000165185 957.2072145 0.848359533 7.09E-08 2.85E-06 UNC93B1 ENSG00000110057 7650.06447 0.586817265 7.14E-08 2.87E-06 FAM20C ENSG00000177706 1555.66437 1.012049327 7.20E-08 2.89E-06 CAPRIN1 ENSG00000135387 13255.47571 0.372066674 7.26E-08 2.90E-06 CARD19 ENSG00000165233 3918.606557 0.902557761 7.31E-08 2.92E-06 RNPEP ENSG00000176393 7834.157447 0.572999208 7.38E-08 2.94E-06 GCSAM ENSG00000174500 763.0463726 -1.200554255 7.53E-08 2.99E-06 H1F0 ENSG00000189060 3707.030769 1.181875975 7.61E-08 3.02E-06 OSCAR ENSG00000170909 5345.953534 0.916185261 7.66E-08 3.04E-06 ZMYND10 ENSG00000004838 253.1723325 -1.124026032 7.69E-08 3.05E-06 ZMYM2 ENSG00000121741 10841.6929 0.454012471 7.85E-08 3.10E-06 ZNF181 ENSG00000197841 706.3655296 -0.921791966 8.05E-08 3.18E-06 SNX13 ENSG00000071189 3368.389421 0.662312234 8.24E-08 3.25E-06 TIGD5 ENSG00000179886 374.1180266 -0.643086429 8.27E-08 3.26E-06 JAG1 ENSG00000101384 614.8423871 1.073721377 8.31E-08 3.26E-06 SLC15A3 ENSG00000110446 4913.288927 0.72039222 8.43E-08 3.31E-06 PDE4D ENSG00000113448 8457.581877 1.279829786 8.45E-08 3.31E-06 TRMT6 ENSG00000089195 2570.813399 0.780422197 8.48E-08 3.32E-06 RBP7 ENSG00000162444 2820.985854 1.071277672 8.61E-08 3.36E-06 PPT1 ENSG00000131238 27853.20228 0.793131083 8.63E-08 3.36E-06 RNASE1 ENSG00000129538 344.5805812 2.093284201 8.70E-08 3.39E-06 PTPN2 ENSG00000175354 6743.778838 0.398315159 8.76E-08 3.40E-06 TMEM135 ENSG00000166575 824.9957664 0.990364834 8.79E-08 3.41E-06 SLAMF6 ENSG00000162739 8864.606765 -0.978861001 8.99E-08 3.47E-06 HEXB ENSG00000049860 9618.795099 0.702990864 8.97E-08 3.47E-06 NFYB ENSG00000120837 1562.698328 -0.441182673 8.98E-08 3.47E-06 ANAPC15 ENSG00000110200 1738.949036 0.533684075 9.17E-08 3.53E-06 SEMA4F ENSG00000135622 697.1974944 -0.684267267 9.22E-08 3.54E-06 LAMP2 ENSG00000005893 13366.32094 0.696976459 9.28E-08 3.56E-06 EPAS1 ENSG00000116016 687.6683195 1.611388027 9.33E-08 3.57E-06 C5orf66 ENSG00000224186 120.4801467 1.109237976 9.41E-08 3.60E-06 DNAJC3 ENSG00000102580 6672.800099 0.729611889 9.62E-08 3.67E-06 CLIP1 ENSG00000130779 7943.391641 0.453925749 9.77E-08 3.71E-06 CDYL2 ENSG00000166446 1765.159858 0.787809122 1.01E-07 3.83E-06 CLTC ENSG00000141367 16170.0993 0.538553873 1.02E-07 3.83E-06 ZNF681 ENSG00000196172 323.4130468 -0.892140308 1.04E-07 3.90E-06 ANPEP ENSG00000166825 25258.01222 1.089294863 1.06E-07 3.97E-06 RNF175 ENSG00000145428 893.2593175 1.001876673 1.06E-07 3.97E-06 ECI2 ENSG00000198721 2356.312725 -0.512586673 1.08E-07 4.01E-06 ZNF516 ENSG00000101493 3380.936841 1.133602518 1.08E-07 4.01E-06 DUSP4 ENSG00000120875 701.3921852 1.790638697 1.09E-07 4.04E-06 ADAMTS2 ENSG00000087116 1421.576412 2.50623852 1.09E-07 4.06E-06 ZNF787 ENSG00000142409 2210.919878 0.680293324 1.10E-07 4.06E-06 TIGAR ENSG00000078237 1123.487712 0.482424656 1.10E-07 4.07E-06

RPAP1 ENSG00000103932 1540.901589 -0.408219092 1.11E-07 4.09E-06 PLK3 ENSG00000173846 5121.419389 1.187883281 1.14E-07 4.18E-06 SSFA2 ENSG00000138434 6463.450426 0.71231932 1.14E-07 4.18E-06 SPRYD7 ENSG00000123178 411.0041576 -0.454469272 1.16E-07 4.25E-06 GRN ENSG00000030582 43726.54744 0.839649641 1.18E-07 4.29E-06 SLC44A1 ENSG00000070214 4210.087846 0.834922976 1.20E-07 4.34E-06 CCNL1 ENSG00000163660 37528.84313 0.521208623 1.21E-07 4.38E-06 AMOT ENSG00000126016 235.8469158 -1.003583963 1.22E-07 4.40E-06 HSPH1 ENSG00000120694 3807.175385 -0.532095796 1.22E-07 4.40E-06 SH3PXD2B ENSG00000174705 446.0553755 2.167649387 1.23E-07 4.42E-06 FAM83G ENSG00000188522 574.3263958 -1.030377415 1.24E-07 4.44E-06 FAM72B ENSG00000188610 208.3890254 0.936537581 1.24E-07 4.45E-06 NDUFAF5 ENSG00000101247 1313.367853 0.894600079 1.26E-07 4.50E-06 CPQ ENSG00000104324 5056.440294 0.710252657 1.27E-07 4.53E-06 ATP2A2 ENSG00000174437 8769.266658 0.769142998 1.28E-07 4.59E-06 RILPL2 ENSG00000150977 7383.261344 0.822150327 1.29E-07 4.59E-06 ZNF226 ENSG00000167380 1117.413651 -0.829295446 1.30E-07 4.63E-06 SELENOP ENSG00000250722 139.2911303 1.328081575 1.34E-07 4.77E-06 KLRB1 ENSG00000111796 6914.478744 -1.081225537 1.39E-07 4.92E-06 PLAUR ENSG00000011422 6776.293144 1.033554306 1.39E-07 4.94E-06 SPRED2 ENSG00000198369 395.148174 1.062758877 1.44E-07 5.09E-06 NEDD4L ENSG00000049759 500.659292 0.846100622 1.52E-07 5.35E-06 GRIK1 ENSG00000171189 69.66473476 1.111127831 1.54E-07 5.42E-06 SNX3 ENSG00000112335 8649.288061 0.578834265 1.54E-07 5.42E-06 BCL6 ENSG00000113916 17361.68985 1.238228898 1.55E-07 5.43E-06 OS9 ENSG00000135506 26906.10232 0.501655784 1.62E-07 5.66E-06 STAU1 ENSG00000124214 7725.154132 0.398754098 1.63E-07 5.68E-06 LY9 ENSG00000122224 4727.989704 -0.846736493 1.63E-07 5.68E-06 ZSWIM3 ENSG00000132801 217.065682 -0.887905347 1.64E-07 5.71E-06 PNKD ENSG00000127838 5138.561551 0.854278195 1.64E-07 5.71E-06 MT-ND1 ENSG00000198888 233954.0184 0.635094515 1.66E-07 5.75E-06 PNMA1 ENSG00000176903 1728.634849 -0.573964651 1.66E-07 5.75E-06 RIOK3 ENSG00000101782 8247.266301 0.776253023 1.68E-07 5.80E-06 TUBGCP3 ENSG00000126216 3758.420748 0.376189418 1.70E-07 5.85E-06 CST3 ENSG00000101439 26574.15341 0.842818733 1.73E-07 5.96E-06 PRSS35 ENSG00000146250 6.779570805 -2.315587936 1.78E-07 6.12E-06 GRIP1 ENSG00000155974 93.01112557 -1.147404654 1.79E-07 6.14E-06 AP3S1 ENSG00000177879 4521.240016 0.591996241 1.80E-07 6.17E-06 ZDHHC3 ENSG00000163812 4308.248402 0.645776676 1.80E-07 6.18E-06 GIMAP6 ENSG00000133561 6417.137104 -0.92754161 1.86E-07 6.36E-06 DOCK1 ENSG00000150760 175.5662111 1.266750441 1.90E-07 6.47E-06 DENND5A ENSG00000184014 13560.95032 0.50373059 1.91E-07 6.50E-06 EIF1B ENSG00000114784 4061.851614 0.579379685 1.95E-07 6.63E-06 RNF152 ENSG00000176641 53.70439112 1.840345158 1.95E-07 6.63E-06 RGS3 ENSG00000138835 3376.615229 -0.717899918 2.00E-07 6.78E-06 IER5L ENSG00000188483 516.3522476 1.32535817 2.02E-07 6.83E-06

CUX1 ENSG00000257923 8653.271916 0.778492196 2.04E-07 6.89E-06 CD274 ENSG00000120217 501.4141403 -0.957954765 2.06E-07 6.96E-06 SERTAD3 ENSG00000167565 2708.590683 0.798496108 2.09E-07 7.04E-06 SDC2 ENSG00000169439 176.2421109 1.705279231 2.15E-07 7.25E-06 FKBP1C ENSG00000198225 627.8924204 0.636426503 2.15E-07 7.25E-06 C9orf72 ENSG00000147894 15322.17534 1.045595128 2.18E-07 7.31E-06 SLC22A15 ENSG00000163393 4674.486845 0.976837158 2.19E-07 7.33E-06 ARL10 ENSG00000175414 1021.228578 -0.917770629 2.20E-07 7.36E-06 GALNT2 ENSG00000143641 5723.539986 0.621634656 2.20E-07 7.37E-06 RBM12B ENSG00000183808 1465.748703 -0.644940489 2.23E-07 7.44E-06 SIRPA ENSG00000198053 17057.84294 0.861569414 2.26E-07 7.53E-06 PKM ENSG00000067225 41909.32296 0.540736272 2.28E-07 7.59E-06 AKTIP ENSG00000166971 2180.939912 -0.53857385 2.34E-07 7.77E-06 GUCY2C ENSG00000070019 676.9609465 1.177448921 2.35E-07 7.81E-06 GPR82 ENSG00000171657 88.1659301 1.293972079 2.42E-07 8.00E-06 RGS14 ENSG00000169220 6731.500224 -0.598567464 2.44E-07 8.02E-06 APBB2 ENSG00000163697 111.0965992 1.426350553 2.45E-07 8.05E-06 SMYD2 ENSG00000143499 2392.138284 -0.419508015 2.47E-07 8.13E-06 ACVRL1 ENSG00000139567 261.8829739 1.506968191 2.49E-07 8.15E-06 MSRA ENSG00000175806 1031.628772 0.655306801 2.49E-07 8.16E-06 CRYZ ENSG00000116791 914.5396854 -0.694748507 2.52E-07 8.21E-06 ALS2CL ENSG00000178038 1046.202272 -0.932886741 2.53E-07 8.25E-06 CMTM6 ENSG00000091317 19018.10872 0.65309359 2.57E-07 8.36E-06 GMNN ENSG00000112312 692.2126439 0.945555038 2.58E-07 8.39E-06 CD2 ENSG00000116824 10196.05647 -0.873577131 2.60E-07 8.41E-06 FOSL2 ENSG00000075426 8280.768704 1.530811609 2.62E-07 8.46E-06 RGL1 ENSG00000143344 687.078084 1.188834044 2.62E-07 8.47E-06 SH2D3C ENSG00000095370 5262.548077 -0.521806576 2.64E-07 8.50E-06 PGBD2 ENSG00000185220 578.8856085 -1.123764281 2.65E-07 8.51E-06 ZC3H15 ENSG00000065548 7176.466225 0.591500591 2.65E-07 8.52E-06 SPATA6 ENSG00000132122 947.0995253 1.026681031 2.68E-07 8.60E-06 NMD3 ENSG00000169251 3525.029693 0.449671137 2.70E-07 8.65E-06 LACTB ENSG00000103642 3567.920988 0.862465509 2.77E-07 8.82E-06 RLF ENSG00000117000 6520.826006 0.715556311 2.83E-07 9.02E-06 USP21 ENSG00000143258 2021.377248 -0.447577181 2.84E-07 9.02E-06 SOAT1 ENSG00000057252 7411.949082 0.634560469 2.85E-07 9.05E-06 ZNF692 ENSG00000171163 2164.399373 -0.748452969 2.92E-07 9.24E-06 CCM2 ENSG00000136280 7230.915411 -0.547422097 2.93E-07 9.25E-06 H1FX ENSG00000184897 8123.705062 0.677847826 2.95E-07 9.30E-06 IRS2 ENSG00000185950 9520.973452 1.481309948 2.96E-07 9.32E-06 HNRNPD ENSG00000138668 25731.06064 0.337994366 2.96E-07 9.33E-06 VSTM1 ENSG00000189068 1542.106944 1.342741907 3.13E-07 9.80E-06 ASAP1 ENSG00000153317 10358.64621 0.712122451 3.15E-07 9.84E-06 RNF139 ENSG00000170881 5510.567403 0.51538351 3.16E-07 9.85E-06 NDUFS6 ENSG00000145494 3250.322647 0.536025303 3.18E-07 9.88E-06 PKD2L1 ENSG00000107593 79.56860037 1.745176371 3.22E-07 1.00E-05

ZNF232 ENSG00000167840 327.0613401 -0.847498167 3.30E-07 1.02E-05 ALDOA ENSG00000149925 36902.50222 0.553005042 3.31E-07 1.03E-05 NVL ENSG00000143748 1662.762019 -0.416400227 3.35E-07 1.04E-05 ENPP5 ENSG00000112796 332.7600427 -1.202762405 3.36E-07 1.04E-05 MAN1A1 ENSG00000111885 10258.98158 0.77389885 3.37E-07 1.04E-05 ANKMY1 ENSG00000144504 2735.407004 -0.467853379 3.38E-07 1.04E-05 CPEB4 ENSG00000113742 3456.499853 1.163039747 3.39E-07 1.04E-05 CKAP2L ENSG00000169607 142.4874056 1.513891258 3.43E-07 1.05E-05 FAM117A ENSG00000121104 7831.03577 -0.798111474 3.46E-07 1.06E-05 NUDT4 ENSG00000173598 3522.777425 0.913787978 3.50E-07 1.07E-05 DDX23 ENSG00000174243 7318.275257 -0.403799816 3.65E-07 1.11E-05 RNF141 ENSG00000110315 9304.115424 0.713568719 3.67E-07 1.12E-05 F3 ENSG00000117525 44.82287607 2.107824683 3.72E-07 1.13E-05 KLF11 ENSG00000172059 7533.969694 0.810221498 3.73E-07 1.13E-05 RNF7 ENSG00000114125 1970.70756 0.82204938 3.76E-07 1.14E-05 NFAM1 ENSG00000235568 11655.98203 0.950842975 3.81E-07 1.15E-05 ELP6 ENSG00000163832 1194.233909 -0.443395368 3.86E-07 1.16E-05 CRIP2 ENSG00000182809 768.3945715 -1.106354009 3.88E-07 1.17E-05 B4GALT5 ENSG00000158470 9039.827159 1.007181812 3.98E-07 1.19E-05 EOMES ENSG00000163508 2013.83621 -1.291181771 3.99E-07 1.20E-05 FNDC3B ENSG00000075420 4288.584671 0.793930404 4.02E-07 1.20E-05 FAM72D ENSG00000215784 169.4871428 0.977197338 4.08E-07 1.22E-05 C1orf43 ENSG00000143612 6098.011037 0.412483693 4.09E-07 1.22E-05 PGBD4 ENSG00000182405 452.024956 -0.586186096 4.31E-07 1.28E-05 CCDC59 ENSG00000133773 3487.251881 0.482773716 4.33E-07 1.28E-05 PTX3 ENSG00000163661 409.2272781 1.318255884 4.35E-07 1.29E-05 C19orf25 ENSG00000119559 859.1121995 -0.725787962 4.41E-07 1.30E-05 MSH2 ENSG00000095002 1547.718447 -0.810706987 4.44E-07 1.31E-05 ACTG1 ENSG00000184009 61816.54612 0.517531614 4.45E-07 1.31E-05 MORF4L1 ENSG00000185787 15101.29808 0.342615668 4.54E-07 1.33E-05 WWP2 ENSG00000198373 6176.674413 0.448719808 4.61E-07 1.34E-05 TFRC ENSG00000072274 6663.415099 0.797950799 4.60E-07 1.34E-05 STRN3 ENSG00000196792 1981.06542 0.609122965 4.60E-07 1.34E-05 FAM46A ENSG00000112773 5567.024175 1.006640589 4.71E-07 1.37E-05 SMYD4 ENSG00000186532 1704.326728 -0.516799922 4.77E-07 1.38E-05 PMPCB ENSG00000105819 6079.787786 0.256866266 4.79E-07 1.38E-05 TBC1D31 ENSG00000156787 1288.644778 -0.661658491 4.79E-07 1.38E-05 IFT20 ENSG00000109083 2026.813674 0.498599646 4.83E-07 1.39E-05 CITED4 ENSG00000179862 440.1788165 1.106117104 5.06E-07 1.45E-05 ING4 ENSG00000111653 2123.1325 -0.487108224 5.06E-07 1.45E-05 ABCA3 ENSG00000167972 696.8874021 -0.730383762 5.05E-07 1.45E-05 PTPN1 ENSG00000196396 9614.506024 0.538267758 5.21E-07 1.49E-05 KIAA0513 ENSG00000135709 2091.866817 0.540385598 5.28E-07 1.51E-05 ZNF804A ENSG00000170396 278.1167655 0.827836167 5.28E-07 1.51E-05 SIT1 ENSG00000137078 804.2663041 -1.025447496 5.31E-07 1.51E-05 KIF13A ENSG00000137177 4341.977498 0.779152448 5.41E-07 1.54E-05

ZNF225 ENSG00000256294 448.4348629 -0.94845804 5.49E-07 1.56E-05 BOLA1 ENSG00000178096 234.716466 -0.907487102 5.62E-07 1.59E-05 DNMBP ENSG00000107554 2100.521206 0.807698513 5.65E-07 1.60E-05 RHEB ENSG00000106615 2363.33079 0.473617428 5.73E-07 1.62E-05 ZNF467 ENSG00000181444 2985.891825 0.853325021 5.74E-07 1.62E-05 LCK ENSG00000182866 14120.98693 -0.93123913 5.80E-07 1.64E-05 ZNF563 ENSG00000188868 109.015312 -1.14653459 5.84E-07 1.64E-05 CD1C ENSG00000158481 1142.556399 -0.851887766 5.86E-07 1.65E-05 SNX2 ENSG00000205302 10895.50757 0.540455518 5.89E-07 1.65E-05 PECAM1 ENSG00000261371 47361.3543 0.644749461 6.00E-07 1.67E-05 GNS ENSG00000135677 24122.6085 0.711498196 6.29E-07 1.74E-05 ATF3 ENSG00000162772 568.6506916 1.217037489 6.43E-07 1.78E-05 TRMT13 ENSG00000122435 3017.788053 -0.741748079 6.44E-07 1.78E-05 FAM110B ENSG00000169122 168.3599134 1.163900104 6.53E-07 1.80E-05 ITSN1 ENSG00000205726 1102.232962 0.956899669 6.57E-07 1.81E-05 RASGEF1B ENSG00000138670 2751.371851 0.956227967 6.62E-07 1.82E-05 PDS5B ENSG00000083642 3259.348637 0.560325854 6.73E-07 1.84E-05 P4HA2 ENSG00000072682 56.46219057 1.328141936 6.74E-07 1.85E-05 SLC31A2 ENSG00000136867 2063.217162 0.83921485 6.84E-07 1.87E-05 ZFP37 ENSG00000136866 121.6460571 -1.144717875 7.01E-07 1.91E-05 POMGNT1 ENSG00000085998 2181.824238 -0.459522925 7.01E-07 1.91E-05 BMP8B ENSG00000116985 1036.717308 -0.497989531 7.03E-07 1.91E-05 TUBD1 ENSG00000108423 516.4465053 -0.635426095 7.04E-07 1.91E-05 EXOC3 ENSG00000180104 7361.442913 0.288070601 7.06E-07 1.91E-05 CROT ENSG00000005469 990.4255285 -0.514113708 7.21E-07 1.95E-05 TOP1 ENSG00000198900 8618.610659 0.654968357 7.28E-07 1.97E-05 SNN ENSG00000184602 12353.04164 0.692344552 7.31E-07 1.98E-05 ZNF691 ENSG00000164011 368.1026918 -0.859683737 7.32E-07 1.98E-05 MICU1 ENSG00000107745 5020.583649 0.559372021 7.41E-07 2.00E-05 ST8SIA4 ENSG00000113532 7553.359858 0.755163596 7.70E-07 2.07E-05 PTGER2 ENSG00000125384 10834.25308 0.730720897 7.76E-07 2.08E-05 NFKBIA ENSG00000100906 35362.15328 1.274100203 7.83E-07 2.09E-05 TXNDC11 ENSG00000153066 5309.133328 0.812371018 7.85E-07 2.09E-05 MNT ENSG00000070444 5171.189174 0.6838098 7.84E-07 2.09E-05 TGFB1 ENSG00000105329 21083.35591 0.482755704 7.92E-07 2.10E-05 ATF4 ENSG00000128272 32961.71544 0.528175944 7.94E-07 2.11E-05 LCORL ENSG00000178177 2120.618426 0.554833822 8.04E-07 2.13E-05 SIRT4 ENSG00000089163 43.28341727 -1.37168608 8.10E-07 2.14E-05 CNPY4 ENSG00000166997 1149.175221 -0.58776325 8.10E-07 2.14E-05 NPC2 ENSG00000119655 11507.60624 0.731932304 8.17E-07 2.16E-05 BNIP2 ENSG00000140299 10751.32807 0.650174745 8.23E-07 2.17E-05 ZFHX3 ENSG00000140836 2473.269834 1.057879608 8.28E-07 2.18E-05 CUL5 ENSG00000166266 2636.716502 0.574222186 8.39E-07 2.21E-05 CD164 ENSG00000135535 18010.76862 0.533800901 8.40E-07 2.21E-05 LUC7L ENSG00000007392 5951.707301 -0.433655646 8.43E-07 2.21E-05 ZNF425 ENSG00000204947 85.79429721 -1.025912265 8.43E-07 2.21E-05

FAM204A ENSG00000165669 3790.72364 0.308641636 8.59E-07 2.24E-05 LIPA ENSG00000107798 16783.24747 0.993446858 8.59E-07 2.24E-05 ECE1 ENSG00000117298 14649.83239 0.705899861 8.89E-07 2.31E-05 C21orf140 ENSG00000222018 37.8765957 -0.997034674 8.90E-07 2.31E-05 KIF13B ENSG00000197892 4878.637848 0.397174321 9.09E-07 2.36E-05 TWNK ENSG00000107815 526.5731088 -0.846136029 9.14E-07 2.37E-05 ANLN ENSG00000011426 232.7686655 1.509150182 9.26E-07 2.40E-05 ADAM17 ENSG00000151694 6833.988442 0.709476138 9.32E-07 2.41E-05 MMP14 ENSG00000157227 876.9514588 1.095906678 9.33E-07 2.41E-05 HDAC6 ENSG00000094631 5357.92371 -0.249066535 9.37E-07 2.42E-05 ANP32B ENSG00000136938 16198.99958 0.353046847 9.41E-07 2.43E-05 WDR5B ENSG00000196981 648.4439181 -0.698605699 9.45E-07 2.43E-05 NDRG2 ENSG00000165795 704.5982242 -0.668537695 9.50E-07 2.44E-05 CTC-529I10.2 ENSG00000227782 205.5643146 0.940376717 9.53E-07 2.45E-05 PSMD6 ENSG00000163636 10398.45731 0.471234502 9.57E-07 2.46E-05 CDK10 ENSG00000185324 4196.729903 -0.507531709 9.63E-07 2.46E-05 RCVRN ENSG00000109047 112.7335879 1.26839997 9.70E-07 2.48E-05 UBE2N ENSG00000177889 5535.624914 0.297317363 9.74E-07 2.48E-05 IGSF8 ENSG00000162729 1715.427236 -0.726344698 9.82E-07 2.50E-05 PHLDA1 ENSG00000139289 740.4750845 1.354386495 9.85E-07 2.50E-05 ANKZF1 ENSG00000163516 5643.378778 -0.421905914 9.92E-07 2.52E-05 TRIQK ENSG00000205133 1517.943603 0.935806121 9.99E-07 2.54E-05 IGFBP3 ENSG00000146674 465.4258225 -1.127357236 1.01E-06 2.55E-05 STIP1 ENSG00000168439 4629.954905 -0.457336357 1.01E-06 2.57E-05 PFKM ENSG00000152556 802.9398525 -0.564400972 1.02E-06 2.59E-05 ARHGEF19 ENSG00000142632 909.9899293 -0.67066952 1.03E-06 2.61E-05 CREBRF ENSG00000164463 5120.803145 0.725186461 1.04E-06 2.62E-05 CAD ENSG00000084774 2776.696535 -0.558005801 1.06E-06 2.67E-05 FAM72A ENSG00000196550 307.2770787 0.834498626 1.07E-06 2.69E-05 ATG7 ENSG00000197548 3701.116317 0.641946696 1.10E-06 2.76E-05 LPCAT4 ENSG00000176454 2523.075561 -0.582763356 1.11E-06 2.77E-05 EREG ENSG00000124882 567.0003122 1.842135011 1.14E-06 2.85E-05 FEZ1 ENSG00000149557 309.8249431 -1.424027609 1.15E-06 2.86E-05 STRAP ENSG00000023734 5899.505475 0.495294128 1.15E-06 2.88E-05 GPRC5A ENSG00000013588 7.648601173 2.299081528 1.17E-06 2.91E-05 PELI1 ENSG00000197329 18439.23291 1.170251225 1.19E-06 2.96E-05 GPR68 ENSG00000119714 571.7397046 -0.89003812 1.21E-06 3.01E-05 GGPS1 ENSG00000152904 2019.722489 -0.545531619 1.23E-06 3.04E-05 SCAF4 ENSG00000156304 7221.047736 0.509452697 1.25E-06 3.08E-05 SUMO3 ENSG00000184900 6863.352775 0.764645254 1.25E-06 3.08E-05 ALAS1 ENSG00000023330 3277.178922 0.684543096 1.26E-06 3.10E-05 GSPT2 ENSG00000189369 640.0054003 -0.531175905 1.27E-06 3.12E-05 SMURF1 ENSG00000198742 3507.150265 0.716956043 1.28E-06 3.15E-05 NRAS ENSG00000213281 7125.749988 0.803106676 1.29E-06 3.15E-05 ZNF287 ENSG00000141040 369.1671345 -0.92411672 1.28E-06 3.15E-05 PLPP3 ENSG00000162407 77.66202845 1.302509423 1.29E-06 3.15E-05

IFNGR2 ENSG00000159128 12945.2132 0.667387977 1.30E-06 3.17E-05 LRRC40 ENSG00000066557 1963.547373 0.447170634 1.30E-06 3.17E-05 METTL7B ENSG00000170439 82.38153221 2.221786987 1.30E-06 3.18E-05 TBC1D30 ENSG00000111490 312.7030113 0.878403108 1.34E-06 3.25E-05 OPLAH ENSG00000178814 387.9135712 0.953531967 1.39E-06 3.38E-05 FCRL3 ENSG00000160856 5722.643603 -1.181732504 1.39E-06 3.38E-05 ZCCHC18 ENSG00000166707 197.5943775 -0.796953245 1.40E-06 3.39E-05 RECK ENSG00000122707 1211.416282 -0.528943879 1.41E-06 3.41E-05 RPAIN ENSG00000129197 2461.740839 -0.354878561 1.41E-06 3.41E-05 TAF1A ENSG00000143498 724.5879651 -0.643981514 1.43E-06 3.45E-05 ALCAM ENSG00000170017 2815.467879 0.744821934 1.43E-06 3.45E-05 ATP6V0D1 ENSG00000159720 10412.33681 0.646861564 1.45E-06 3.47E-05 CD79B ENSG00000007312 2499.468568 -0.964095051 1.45E-06 3.49E-05 OPA1 ENSG00000198836 5518.541409 0.432248575 1.46E-06 3.49E-05 MGAT1 ENSG00000131446 21180.16705 0.617561921 1.47E-06 3.51E-05 TMEM11 ENSG00000178307 1310.935241 0.589072403 1.48E-06 3.53E-05 ZNF391 ENSG00000124613 146.935651 -1.218603156 1.48E-06 3.53E-05 PCDH1 ENSG00000156453 209.9759337 -1.589737148 1.48E-06 3.53E-05 RAE1 ENSG00000101146 3328.360999 0.385635849 1.53E-06 3.62E-05 USB1 ENSG00000103005 5325.924897 0.605377656 1.54E-06 3.64E-05 HMGXB4 ENSG00000100281 2387.313532 0.551608716 1.55E-06 3.67E-05 KIR3DX1 ENSG00000104970 945.2707499 1.803465246 1.56E-06 3.69E-05 CDH5 ENSG00000179776 42.73372683 2.030909585 1.57E-06 3.69E-05 TUBB4A ENSG00000104833 102.3020638 -1.486139862 1.57E-06 3.69E-05 TCEB1 ENSG00000154582 1844.246568 0.366018277 1.59E-06 3.75E-05 ITPK1 ENSG00000100605 10619.3394 0.547871547 1.60E-06 3.76E-05 FUT2 ENSG00000176920 57.93752714 -1.136788616 1.61E-06 3.79E-05 COPS3 ENSG00000141030 2614.666443 0.457812761 1.64E-06 3.85E-05 TNFRSF1B ENSG00000028137 54100.80368 0.6190167 1.65E-06 3.88E-05 CEP70 ENSG00000114107 377.9247854 -0.686104034 1.69E-06 3.96E-05 FANCE ENSG00000112039 463.9021775 -0.764608123 1.71E-06 4.00E-05 DOCK2 ENSG00000134516 36108.25635 0.38549369 1.76E-06 4.08E-05 UBAP1 ENSG00000165006 6438.168398 0.625853846 1.78E-06 4.12E-05 HPCAL4 ENSG00000116983 596.5854487 -1.087272664 1.80E-06 4.15E-05 ADAM22 ENSG00000008277 437.9677618 -0.633271097 1.86E-06 4.29E-05 CCL24 ENSG00000106178 84.74301558 2.246898018 1.86E-06 4.29E-05 CD160 ENSG00000117281 919.1424149 -1.239010153 1.89E-06 4.34E-05 NR6A1 ENSG00000148200 483.3882758 1.044382469 1.90E-06 4.35E-05 FKBP4 ENSG00000004478 2455.896259 -0.687450437 1.91E-06 4.38E-05 COLEC12 ENSG00000158270 117.5249594 1.85116325 1.91E-06 4.38E-05 HNRNPUL1 ENSG00000105323 28383.30055 0.363917797 1.93E-06 4.40E-05 CETN3 ENSG00000153140 371.3919748 -0.945944488 1.92E-06 4.40E-05 ME1 ENSG00000065833 291.4445524 1.259911785 1.93E-06 4.40E-05 GNA13 ENSG00000120063 20026.77367 0.562927923 1.93E-06 4.40E-05 CD3G ENSG00000160654 3976.253322 -1.09723353 1.93E-06 4.40E-05 ELK1 ENSG00000126767 2346.236966 0.440798687 1.94E-06 4.41E-05

ILF2 ENSG00000143621 9710.302801 0.349185043 1.95E-06 4.43E-05 GZMK ENSG00000113088 3927.404419 -1.059438477 1.98E-06 4.49E-05 MMS19 ENSG00000155229 5776.392904 -0.264286404 1.99E-06 4.50E-05 CPE ENSG00000109472 34.48171793 1.998359053 1.99E-06 4.52E-05 LONRF1 ENSG00000154359 2290.977181 0.838863871 2.04E-06 4.61E-05 RSRC2 ENSG00000111011 9255.889141 0.598449589 2.05E-06 4.63E-05 TALDO1 ENSG00000177156 21231.7712 0.672053372 2.06E-06 4.65E-05 OXA1L ENSG00000155463 12156.8164 0.35417612 2.07E-06 4.67E-05 SH3YL1 ENSG00000035115 2076.80578 -0.576325734 2.08E-06 4.69E-05 FLT3 ENSG00000122025 2991.601162 1.778704217 2.09E-06 4.69E-05 CCRL2 ENSG00000121797 347.3097488 0.882356768 2.12E-06 4.75E-05 CLIC5 ENSG00000112782 281.7863601 -0.811371184 2.14E-06 4.79E-05 PNPLA2 ENSG00000177666 9968.686353 0.556043943 2.14E-06 4.79E-05 MARCH1 ENSG00000186205 3317.053745 1.074986527 2.14E-06 4.80E-05 HJURP ENSG00000123485 322.2916493 1.533522073 2.16E-06 4.83E-05 MPP5 ENSG00000072415 1269.82241 0.508686961 2.16E-06 4.83E-05 UBALD2 ENSG00000185262 11493.43965 0.806261288 2.19E-06 4.88E-05 C1orf109 ENSG00000116922 717.0274245 -0.568011233 2.20E-06 4.91E-05 LRRC59 ENSG00000108829 4782.942821 0.666848003 2.20E-06 4.91E-05 LTA4H ENSG00000111144 35138.50074 0.864613711 2.22E-06 4.93E-05 FNDC11 ENSG00000125531 89.6364855 -0.998149264 2.24E-06 4.99E-05 SLC35E4 ENSG00000100036 136.9696292 0.937362439 2.27E-06 5.03E-05 MTMR14 ENSG00000163719 8665.33947 0.424825 2.29E-06 5.08E-05 ATP2B1 ENSG00000070961 12167.56486 0.816294337 2.31E-06 5.11E-05 CDK16 ENSG00000102225 4264.274191 0.646856689 2.31E-06 5.12E-05 KIAA0907 ENSG00000132680 6512.982926 -0.340718611 2.34E-06 5.16E-05 SORT1 ENSG00000134243 7064.36656 0.930241538 2.41E-06 5.31E-05 USP20 ENSG00000136878 4400.605665 -0.494629815 2.43E-06 5.35E-05 IQSEC2 ENSG00000124313 1561.988517 0.649262398 2.44E-06 5.36E-05 ZNF697 ENSG00000143067 551.5629229 0.838307008 2.49E-06 5.46E-05 ACAP1 ENSG00000072818 21369.9562 -0.550524672 2.50E-06 5.48E-05 EMC7 ENSG00000134153 2529.831742 0.421605899 2.50E-06 5.48E-05 GLT1D1 ENSG00000151948 6472.256606 0.870091821 2.51E-06 5.49E-05 WASF2 ENSG00000158195 26570.57799 0.422338346 2.53E-06 5.53E-05 GSG2 ENSG00000177602 119.2818649 1.220305946 2.56E-06 5.57E-05 LRRN3 ENSG00000173114 635.1209777 -1.231654886 2.56E-06 5.57E-05 MKS1 ENSG00000011143 532.6086679 -0.700709344 2.57E-06 5.58E-05 TMEM68 ENSG00000167904 691.8042059 -0.462547012 2.57E-06 5.59E-05 TFDP1 ENSG00000198176 3911.607454 0.555803434 2.59E-06 5.61E-05 UTP6 ENSG00000108651 3558.137638 -0.49263534 2.61E-06 5.65E-05 JMJD1C ENSG00000171988 16534.61176 0.808326418 2.64E-06 5.72E-05 SPA17 ENSG00000064199 143.6694928 1.009420534 2.65E-06 5.74E-05 SPEF2 ENSG00000152582 786.6723804 -0.701244943 2.65E-06 5.74E-05 MEF2D ENSG00000116604 11224.97825 0.675576989 2.65E-06 5.74E-05 KIF21A ENSG00000139116 999.9758603 -0.752650462 2.68E-06 5.79E-05 GPX3 ENSG00000211445 229.5478061 1.353844898 2.69E-06 5.80E-05

NFATC2 ENSG00000101096 5728.67735 -0.844756247 2.71E-06 5.83E-05 HES1 ENSG00000114315 107.230914 1.727867469 2.72E-06 5.85E-05 EDC3 ENSG00000179151 1716.017569 -0.4663906 2.74E-06 5.88E-05 WNK1 ENSG00000060237 17908.56464 0.505324769 2.75E-06 5.90E-05 TMEM50A ENSG00000183726 11055.2528 0.340328782 2.76E-06 5.91E-05 KBTBD3 ENSG00000182359 300.4193759 -0.59910832 2.79E-06 5.96E-05 OLFML2B ENSG00000162745 165.403312 1.242941822 2.80E-06 5.98E-05 CWC15 ENSG00000150316 4046.581455 0.280110979 2.84E-06 6.04E-05 CTNNA1 ENSG00000044115 9692.491382 0.644450367 2.84E-06 6.04E-05 WTAP ENSG00000146457 13646.0049 0.472118632 2.88E-06 6.12E-05 FBXO44 ENSG00000132879 2363.595018 -0.626727997 2.89E-06 6.13E-05 NUS1 ENSG00000153989 6268.379933 0.432408774 2.91E-06 6.17E-05 ZNF786 ENSG00000197362 607.4866584 -0.721047263 2.92E-06 6.19E-05 ERBB2 ENSG00000141736 1255.340864 -1.083272061 2.93E-06 6.19E-05 DHCR24 ENSG00000116133 700.2725682 -1.127675721 2.95E-06 6.23E-05 FAM110C ENSG00000184731 67.05767382 -1.679698881 2.98E-06 6.30E-05 VAV3 ENSG00000134215 5999.008059 0.489054548 2.98E-06 6.30E-05 ERP44 ENSG00000023318 8792.991953 0.411486387 3.00E-06 6.33E-05 TRIB2 ENSG00000071575 7232.37846 -0.719618705 3.01E-06 6.34E-05 DYM ENSG00000141627 3953.648936 0.461156903 3.02E-06 6.37E-05 TNNI2 ENSG00000130598 557.2193428 0.642362263 3.03E-06 6.37E-05 NMNAT2 ENSG00000157064 52.49991526 1.684575214 3.07E-06 6.45E-05 SCARB2 ENSG00000138760 8108.049991 0.65089951 3.09E-06 6.48E-05 DRAM1 ENSG00000136048 1040.131452 1.003516272 3.11E-06 6.52E-05 CFL2 ENSG00000165410 1130.41681 0.922593207 3.14E-06 6.57E-05 ZNF185 ENSG00000147394 4782.722833 0.695875381 3.17E-06 6.61E-05 SPATC1 ENSG00000186583 102.7474864 1.354461114 3.18E-06 6.64E-05 TRAK1 ENSG00000182606 7124.674948 0.383230495 3.21E-06 6.68E-05 RPF1 ENSG00000117133 5041.226006 0.339912092 3.25E-06 6.76E-05 GRAP ENSG00000154016 2305.516228 -0.867752625 3.36E-06 6.94E-05 LARP4B ENSG00000107929 8358.431556 0.41719436 3.37E-06 6.96E-05 KL ENSG00000133116 102.14938 1.367551286 3.43E-06 7.07E-05 FAM78A ENSG00000126882 10633.39746 -0.44873187 3.49E-06 7.17E-05 SLC1A3 ENSG00000079215 200.0202959 1.501429462 3.49E-06 7.17E-05 GCDH ENSG00000105607 1389.58857 -0.410021854 3.49E-06 7.17E-05 CEP68 ENSG00000011523 2280.650179 -0.462382112 3.52E-06 7.22E-05 LRRC45 ENSG00000169683 1175.943261 -0.468644568 3.52E-06 7.22E-05 PPOX ENSG00000143224 1513.840704 -0.564842473 3.57E-06 7.30E-05 ARHGDIA ENSG00000141522 17092.84032 0.520778652 3.61E-06 7.37E-05 KLHL15 ENSG00000174010 2119.672808 0.82469383 3.61E-06 7.37E-05 PTCH1 ENSG00000185920 1938.160482 -0.991916058 3.63E-06 7.40E-05 NMT2 ENSG00000152465 1505.771463 -0.852518141 3.64E-06 7.42E-05 RNF10 ENSG00000022840 12010.18729 0.624691247 3.70E-06 7.51E-05 UQCC1 ENSG00000101019 2652.72797 -0.577579847 3.72E-06 7.53E-05 CD200R1 ENSG00000163606 585.2948296 -1.10159857 3.73E-06 7.56E-05 AC006116.20 ENSG00000267710 54.24417681 -1.041030316 3.79E-06 7.66E-05

CHRM5 ENSG00000184984 82.25340756 -0.921895965 3.81E-06 7.68E-05 FAM160B1 ENSG00000151553 3473.180028 0.768770327 3.84E-06 7.73E-05 TAF13 ENSG00000197780 875.5788747 0.736991898 3.85E-06 7.76E-05 IL1R2 ENSG00000115590 4541.927331 2.031152163 3.89E-06 7.83E-05 SLC7A7 ENSG00000155465 12973.17079 0.692125533 3.93E-06 7.90E-05 U2AF1 ENSG00000160201 8708.350726 0.717330812 4.06E-06 8.14E-05 TLE2 ENSG00000065717 492.0164965 -1.075309088 4.07E-06 8.14E-05 SLC31A1 ENSG00000136868 3742.549975 0.765909818 4.09E-06 8.17E-05 RASA1 ENSG00000145715 5589.397437 0.43726949 4.11E-06 8.20E-05 ZMYND19 ENSG00000165724 939.2329878 -0.558945515 4.13E-06 8.23E-05 CTIF ENSG00000134030 1247.504708 0.859840578 4.15E-06 8.27E-05 SH3TC1 ENSG00000125089 5635.619291 0.613882971 4.19E-06 8.33E-05 PDCD7 ENSG00000090470 1648.032597 -0.485213019 4.26E-06 8.46E-05 OLA1 ENSG00000138430 3822.547026 0.429182955 4.26E-06 8.46E-05 CCDC102A ENSG00000135736 422.9027693 -0.900658559 4.34E-06 8.62E-05 SERPINH1 ENSG00000149257 375.9681424 -0.661132433 4.38E-06 8.67E-05 POLH ENSG00000170734 986.8546481 -0.776440736 4.50E-06 8.89E-05 UMPS ENSG00000114491 851.0082934 -0.677452509 4.53E-06 8.94E-05 THNSL1 ENSG00000185875 193.8887793 -1.08850627 4.60E-06 9.03E-05 TRAPPC6B ENSG00000182400 3405.257783 -0.407391753 4.62E-06 9.06E-05 SLC39A11 ENSG00000133195 1811.827819 0.535342414 4.65E-06 9.11E-05 ALOX5 ENSG00000012779 22628.69676 0.715749978 4.66E-06 9.11E-05 MAP3K1 ENSG00000095015 23291.80663 0.594777963 4.72E-06 9.22E-05 ELP2 ENSG00000134759 4088.665221 -0.499233943 4.77E-06 9.31E-05 GMFB ENSG00000197045 3614.458247 0.912499674 4.80E-06 9.35E-05 ZNF175 ENSG00000105497 814.6264466 -0.895549174 4.83E-06 9.38E-05 CH25H ENSG00000138135 29.78279331 2.062405724 4.86E-06 9.44E-05 AFAP1L2 ENSG00000169129 199.4692692 -0.949844272 4.93E-06 9.53E-05 FRG1 ENSG00000109536 2758.756106 0.295887945 4.94E-06 9.55E-05 ACRC ENSG00000147174 640.5896161 -0.585063181 4.97E-06 9.60E-05 LIPE ENSG00000079435 299.2655282 -0.710585513 5.00E-06 9.63E-05 PLEKHG4 ENSG00000196155 892.7350946 -0.689756213 5.01E-06 9.64E-05 RARS2 ENSG00000146282 3554.086603 0.254555056 5.03E-06 9.67E-05 COQ6 ENSG00000119723 1264.854819 -0.432369495 5.03E-06 9.67E-05 KIF1BP ENSG00000198954 679.9704665 -0.645358753 5.05E-06 9.70E-05 PXK ENSG00000168297 5830.515824 0.662371596 5.07E-06 9.72E-05 SIGIRR ENSG00000185187 8623.015049 -0.680309045 5.08E-06 9.73E-05 PLXDC2 ENSG00000120594 8294.722465 0.745350456 5.16E-06 9.85E-05 TCTN2 ENSG00000168778 341.3235686 -0.847655512 5.18E-06 9.88E-05 ZNF792 ENSG00000180884 824.2823229 -0.886980318 5.19E-06 9.88E-05 FAM105A ENSG00000145569 4741.41568 0.712354743 5.19E-06 9.88E-05 HENMT1 ENSG00000162639 1599.288778 -0.434626448 5.22E-06 9.92E-05 ABCD2 ENSG00000173208 1102.285105 -0.806926081 5.22E-06 9.92E-05 CDC42 ENSG00000070831 38373.36107 0.352030333 5.28E-06 9.99E-05 OLFM2 ENSG00000105088 138.9920819 -1.514429414 5.28E-06 9.99E-05 APP ENSG00000142192 11158.73714 0.566532496 5.34E-06 0.000100931

HDGF ENSG00000143321 11571.55606 0.482192488 5.35E-06 0.000101097 PSMB7 ENSG00000136930 7941.119286 0.302626858 5.38E-06 0.000101504 FABP5 ENSG00000164687 674.5485351 0.869226427 5.41E-06 0.000102038 CPNE8 ENSG00000139117 2234.061207 0.773302521 5.43E-06 0.000102241 PROSER1 ENSG00000120685 5456.673232 0.468723812 5.49E-06 0.000103245 FCRL6 ENSG00000181036 3685.940394 -1.028582969 5.50E-06 0.00010329 METTL13 ENSG00000010165 1258.130718 -0.720509375 5.56E-06 0.000104117 ZFP62 ENSG00000196670 1524.47224 -0.772456342 5.60E-06 0.000104756 EPHX4 ENSG00000172031 50.48446493 -1.738439047 5.67E-06 0.000105825 EIF4G1 ENSG00000114867 15505.25593 0.340160227 5.72E-06 0.000106564 BNIP3L ENSG00000104765 13304.22414 0.805795344 5.78E-06 0.000107511 SDCCAG3 ENSG00000165689 2535.758525 -0.498242132 5.78E-06 0.000107511 SREK1 ENSG00000153914 9754.343869 0.471095551 5.78E-06 0.000107511 SEC24D ENSG00000150961 3474.712697 0.549867998 5.79E-06 0.000107565 PLB1 ENSG00000163803 2392.924251 0.880861238 5.79E-06 0.000107565 UFD1L ENSG00000070010 6463.398579 0.462547004 5.83E-06 0.000107983 PSMD12 ENSG00000197170 3231.214105 0.515282499 5.92E-06 0.00010941 AZIN1 ENSG00000155096 7490.545248 0.592887455 5.93E-06 0.000109446 FAM160B2 ENSG00000158863 5038.155258 -0.477383807 5.98E-06 0.000110151 SF3B6 ENSG00000115128 3790.37533 0.381604453 6.05E-06 0.000111388 TEKT2 ENSG00000092850 21.74995661 1.826964634 6.08E-06 0.000111735 BCL2A1 ENSG00000140379 8819.545659 1.08041714 6.17E-06 0.000113055 UNC119B ENSG00000175970 2223.903082 -0.403015881 6.18E-06 0.000113182 CARS2 ENSG00000134905 9930.676741 0.381120134 6.20E-06 0.000113542 MAML3 ENSG00000196782 2125.600492 0.789267505 6.23E-06 0.00011387 SAPCD2 ENSG00000186193 539.8000498 0.949777132 6.27E-06 0.000114525 RANBP9 ENSG00000010017 6033.890232 0.317732061 6.35E-06 0.000115694 MTMR10 ENSG00000166912 5879.225632 0.430296666 6.43E-06 0.000116999 BTBD6 ENSG00000184887 2249.066272 -0.565006381 6.59E-06 0.000119582 OGFR ENSG00000060491 12246.38139 0.463884514 6.66E-06 0.000120413 SCLT1 ENSG00000151466 4158.341485 0.630957902 6.74E-06 0.000121689 NAP1L3 ENSG00000186310 209.78857 -0.865052867 6.81E-06 0.000122759 SPTLC1 ENSG00000090054 3936.87252 0.506317281 6.89E-06 0.000124107 UBE2E2 ENSG00000182247 1210.413299 0.796507957 6.94E-06 0.000124845 PPP1R1A ENSG00000135447 59.56039316 0.912680694 6.97E-06 0.000125235 ICA1 ENSG00000003147 492.2167743 0.906198906 7.01E-06 0.000125827 USP32 ENSG00000170832 7009.223898 0.611782862 7.19E-06 0.000128368 VRK2 ENSG00000028116 3045.43899 0.469256257 7.25E-06 0.000129202 PAIP2B ENSG00000124374 609.982619 -0.686600529 7.32E-06 0.000130309 CCNB2 ENSG00000157456 245.6803425 1.230401353 7.33E-06 0.000130321 MAP4K4 ENSG00000071054 16888.46482 0.432129142 7.36E-06 0.000130707 FCMR ENSG00000162894 7220.851237 -0.634757051 7.46E-06 0.000132108 PLXNA2 ENSG00000076356 629.1934877 0.848498288 7.47E-06 0.000132195 PPM1B ENSG00000138032 6311.302999 0.599744198 7.48E-06 0.000132339 TRIM46 ENSG00000163462 595.615289 -0.76617882 7.56E-06 0.000133591 TNFSF8 ENSG00000106952 4735.980305 0.495727654 7.61E-06 0.000134233

FAM49A ENSG00000197872 9765.121374 0.740953336 7.62E-06 0.000134328 RINL ENSG00000187994 2202.639621 -0.622868931 7.63E-06 0.000134434 SGCB ENSG00000163069 386.467518 -0.681319515 7.63E-06 0.000134445 HAPLN3 ENSG00000140511 2476.381432 -0.843283205 7.67E-06 0.000134903 TMEM229B ENSG00000198133 1625.355878 -0.755901001 7.68E-06 0.000134942 SIPA1L2 ENSG00000116991 1445.027839 1.014662892 7.81E-06 0.000136909 SMG7 ENSG00000116698 9445.391297 0.437902415 7.85E-06 0.000137387 LMTK2 ENSG00000164715 5669.854924 0.705540517 7.91E-06 0.000138296 ZNF415 ENSG00000170954 98.59802088 -0.993153409 7.91E-06 0.000138296 CAPN12 ENSG00000182472 335.175528 -0.733556657 7.94E-06 0.000138711 SERPINA1 ENSG00000197249 54995.93868 0.670613114 8.01E-06 0.000139789 ZBTB12 ENSG00000204366 82.84890588 -1.196642447 8.01E-06 0.000139817 SLC28A3 ENSG00000197506 304.9531538 1.400563525 8.06E-06 0.000140374 MAP1S ENSG00000130479 1969.614125 0.860591371 8.11E-06 0.000141214 POP1 ENSG00000104356 267.9094589 -0.838591953 8.17E-06 0.00014212 BCDIN3D ENSG00000186666 332.3473178 -0.806292208 8.22E-06 0.000142635 MIER2 ENSG00000105556 1547.405127 0.463324771 8.23E-06 0.000142806 TMEM67 ENSG00000164953 222.2225131 -0.566856469 8.37E-06 0.000144969 PPP1R3F ENSG00000049769 489.1628079 -0.580313074 8.40E-06 0.000145243 CTCF ENSG00000102974 5562.915383 -0.328819175 8.54E-06 0.000147525 ANXA1 ENSG00000135046 59401.13515 0.685184655 8.56E-06 0.000147687 PHF21A ENSG00000135365 10856.43733 0.477233034 8.58E-06 0.000148052 TNRC18 ENSG00000182095 10403.27752 0.35499393 8.59E-06 0.000148085 RRBP1 ENSG00000125844 6064.731036 0.578967106 8.61E-06 0.000148407 TP53INP2 ENSG00000078804 2064.15145 1.034280434 8.65E-06 0.000148923 ZNF606 ENSG00000166704 908.3999113 -0.774839039 8.69E-06 0.000149445 MGST1 ENSG00000008394 1336.743021 0.925697291 8.74E-06 0.000149957 RTN4 ENSG00000115310 14876.04752 0.51698458 8.74E-06 0.000149957 SYBU ENSG00000147642 42.20124892 -1.321287289 8.78E-06 0.000150499 ZNF382 ENSG00000161298 379.9945033 -0.945965271 8.79E-06 0.000150687 CYP19A1 ENSG00000137869 23.21216667 2.037734371 8.82E-06 0.000151022 ARFRP1 ENSG00000101246 1857.606036 -0.482391965 8.93E-06 0.00015263 TESPA1 ENSG00000135426 6195.226575 -0.653123229 8.99E-06 0.000153502 C18orf25 ENSG00000152242 5274.798288 0.463278231 9.03E-06 0.000153991 TNNT1 ENSG00000105048 469.9716045 1.478361045 9.06E-06 0.000154243 SESTD1 ENSG00000187231 2710.351928 0.856190967 9.12E-06 0.000155308 LRFN3 ENSG00000126243 273.7346662 -0.865560829 9.15E-06 0.000155669 TARS2 ENSG00000143374 1804.218963 -0.418947025 9.17E-06 0.000155806 EGLN3 ENSG00000129521 153.8850905 -0.965639714 9.17E-06 0.000155806 FAM13A ENSG00000138640 4031.432684 0.932521052 9.26E-06 0.000157061 SH2D4A ENSG00000104611 24.12231701 1.661040726 9.36E-06 0.000158588 FBN2 ENSG00000138829 1780.003747 0.928753288 9.39E-06 0.000158997 ARSB ENSG00000113273 2581.985281 0.546519941 9.44E-06 0.000159739 FLT4 ENSG00000037280 324.3659827 -0.849947388 9.48E-06 0.000160222 ZNF91 ENSG00000167232 2157.655076 -0.618754771 9.56E-06 0.000161442 TMEM171 ENSG00000157111 27.0687671 -1.824426709 9.57E-06 0.000161514

NBPF3 ENSG00000142794 659.2016637 -1.013610827 9.80E-06 0.000165138 ATP6V1G1 ENSG00000136888 9910.802804 0.262618237 9.90E-06 0.000166682 JAKMIP2 ENSG00000176049 654.5142263 -1.006896055 9.99E-06 0.000167984 ZNF644 ENSG00000122482 2232.287231 0.54130881 1.02E-05 0.000171457 SYK ENSG00000165025 19910.25818 0.693501278 1.03E-05 0.000172675 DIAPH3 ENSG00000139734 50.03612578 1.581450589 1.04E-05 0.000172891 GRIN2C ENSG00000161509 224.5017169 1.050038342 1.04E-05 0.000173249 HEBP2 ENSG00000051620 6788.182316 0.434385973 1.04E-05 0.000173587 PTP4A3 ENSG00000184489 1190.931088 -0.695256828 1.04E-05 0.000173587 LONRF3 ENSG00000175556 1371.090294 1.326683224 1.04E-05 0.000173765 KLC4 ENSG00000137171 1237.171312 -0.385833661 1.05E-05 0.000175224 ARHGAP26 ENSG00000145819 11912.4037 0.816750903 1.06E-05 0.000176152 PYGL ENSG00000100504 15032.1418 0.849006416 1.06E-05 0.000176699 CHD3 ENSG00000170004 23487.8373 -0.392436467 1.07E-05 0.000177519 NHSL1 ENSG00000135540 289.2106127 0.834083843 1.09E-05 0.000180549 ZNF302 ENSG00000089335 2849.947505 -0.467457618 1.09E-05 0.000181083 DPH2 ENSG00000132768 1337.716173 -0.485614057 1.10E-05 0.000181567 MMP19 ENSG00000123342 134.9740045 1.457043609 1.10E-05 0.000181567 ZNF337 ENSG00000130684 5259.108387 -0.387534882 1.10E-05 0.000181585 PLD4 ENSG00000166428 1118.727564 -0.98738897 1.11E-05 0.000182392 RSG1 ENSG00000132881 113.3518237 -0.92317855 1.11E-05 0.000182619 BAIAP2L1 ENSG00000006453 1188.607377 0.778762516 1.12E-05 0.00018345 TP53I3 ENSG00000115129 886.1891082 0.685650415 1.12E-05 0.00018345 CEACAM4 ENSG00000105352 7676.625381 1.228550554 1.12E-05 0.000183545 SMKR1 ENSG00000240204 82.2060576 -1.21803332 1.12E-05 0.000183891 ACAT2 ENSG00000120437 1213.837174 -0.488332331 1.14E-05 0.000185905 TRA2B ENSG00000136527 14972.11807 0.385539526 1.16E-05 0.000188623 ANO9 ENSG00000185101 4201.490464 -0.732643924 1.16E-05 0.000188669 ARHGAP25 ENSG00000163219 15771.64167 -0.446834267 1.16E-05 0.000189199 EHMT2 ENSG00000204371 4387.737187 -0.406698286 1.16E-05 0.000189223 ZNF579 ENSG00000218891 398.0753347 0.573741672 1.16E-05 0.000189223 HYLS1 ENSG00000198331 250.6065584 -0.774297838 1.16E-05 0.000189284 CPTP ENSG00000224051 826.5431794 -0.50758558 1.17E-05 0.000189803 ZNF365 ENSG00000138311 310.3776114 -1.166373269 1.17E-05 0.000189822 RILP ENSG00000167705 594.8646958 0.614119075 1.17E-05 0.000190004 MT1F ENSG00000198417 299.7746776 0.864257935 1.17E-05 0.000190345 PCNX1 ENSG00000100731 15057.31817 0.595824554 1.18E-05 0.000191386 HK2 ENSG00000159399 6951.956379 0.667801996 1.18E-05 0.000191671 KCNG2 ENSG00000178342 13.30786962 1.743546085 1.19E-05 0.000191966 CTDSPL2 ENSG00000137770 3095.294962 0.632796943 1.21E-05 0.000194694 GAB1 ENSG00000109458 1010.098833 0.99621138 1.22E-05 0.000196276 ZFP28 ENSG00000196867 407.3924647 -0.650334 1.22E-05 0.000196276 GNL2 ENSG00000134697 4081.889508 0.244529406 1.23E-05 0.000197582 FNIP2 ENSG00000052795 2908.235236 0.576784632 1.23E-05 0.000198238 PLEKHB1 ENSG00000021300 1263.392078 -0.806161126 1.23E-05 0.00019832 DPYD ENSG00000188641 12213.58099 0.642414802 1.24E-05 0.000199286

ZNF202 ENSG00000166261 1798.347403 -0.5168559 1.25E-05 0.000200191 NAMPTP1 ENSG00000229644 5401.523563 1.573817393 1.26E-05 0.000201684 FZD5 ENSG00000163251 128.503126 1.028542856 1.26E-05 0.000202261 NAGS ENSG00000161653 58.63463848 -1.181982466 1.27E-05 0.000203022 CCDC88A ENSG00000115355 6550.505148 0.759591932 1.28E-05 0.000203477 PCYT2 ENSG00000185813 1370.88494 -0.504265486 1.28E-05 0.000203898 IQGAP2 ENSG00000145703 16732.7483 0.575934453 1.28E-05 0.000203945 NDUFB4 ENSG00000065518 1311.776618 0.630202281 1.28E-05 0.000203971 EXOSC8 ENSG00000120699 2269.646112 -0.467598282 1.29E-05 0.000204134 MON1A ENSG00000164077 467.1475104 -0.765229325 1.29E-05 0.000204937 PPFIA1 ENSG00000131626 4814.015503 0.453439177 1.30E-05 0.000206593 TPM3 ENSG00000143549 29149.97789 0.378531774 1.31E-05 0.000207962 TOMM20 ENSG00000173726 10633.88952 0.278322959 1.32E-05 0.000209078 HTRA1 ENSG00000166033 213.35564 1.476566642 1.32E-05 0.000209078 CDC42EP4 ENSG00000179604 878.5640112 0.737921022 1.34E-05 0.000211576 TMED5 ENSG00000117500 8269.619725 0.494860388 1.34E-05 0.000211974 ZCCHC6 ENSG00000083223 15063.95119 0.655810659 1.35E-05 0.000212487 PDE4DIP ENSG00000178104 3109.410358 -0.565689042 1.36E-05 0.000214044 RBM3 ENSG00000102317 22856.56571 0.426589504 1.36E-05 0.000214174 CDK4 ENSG00000135446 1358.873206 -0.594564399 1.38E-05 0.000215954 S100A11 ENSG00000163191 23427.12247 0.732553497 1.38E-05 0.000216459 ZNF154 ENSG00000179909 654.0999848 -0.842701361 1.41E-05 0.000220861 RUSC2 ENSG00000198853 1369.180416 0.708330045 1.41E-05 0.00022089 ADPGK ENSG00000159322 15289.00024 0.400842221 1.42E-05 0.000222543 RHOBTB2 ENSG00000008853 1381.343406 -0.577501209 1.43E-05 0.000222543 CERS4 ENSG00000090661 1150.229166 -0.623869505 1.43E-05 0.000222931 BAALC ENSG00000164929 43.82842976 -1.193079742 1.43E-05 0.000222931 ANKRD34A ENSG00000272031 153.0757925 -0.768674229 1.44E-05 0.000224233 RRAGD ENSG00000025039 1329.350281 0.774104196 1.44E-05 0.000224283 CALCRL ENSG00000064989 319.4635156 1.02570588 1.44E-05 0.000224285 INPP5E ENSG00000148384 2076.63172 -0.435867863 1.44E-05 0.000224285 TNFSF4 ENSG00000117586 286.0510855 -0.826148741 1.45E-05 0.000224726 KLHL6 ENSG00000172578 3991.158719 -0.490597377 1.45E-05 0.000224726 DNAJA2 ENSG00000069345 4564.352156 0.41499812 1.46E-05 0.000225856 MCTP1 ENSG00000175471 4504.715395 0.61117809 1.46E-05 0.000226095 B4GAT1 ENSG00000174684 223.2165768 -0.722153787 1.49E-05 0.000229861 SLC29A1 ENSG00000112759 1046.986993 0.680571667 1.49E-05 0.000229972 PLAU ENSG00000122861 142.1384898 1.480034613 1.51E-05 0.000232095 CNIH1 ENSG00000100528 3033.741676 0.448578358 1.51E-05 0.000232349 GDAP2 ENSG00000196505 2675.910765 0.493809807 1.51E-05 0.000232373 TMEM204 ENSG00000131634 1021.228481 -0.962682197 1.52E-05 0.000233122 PRMT3 ENSG00000185238 1615.091402 0.423291906 1.53E-05 0.000234015 TRIM68 ENSG00000167333 813.8129249 -0.677113337 1.53E-05 0.000234015 BOK ENSG00000176720 131.0586246 -1.462587808 1.53E-05 0.000234015 PPIAL4G ENSG00000236334 15.39541903 -1.332881529 1.54E-05 0.000235126 NPAS2 ENSG00000170485 169.1945802 -1.015624639 1.56E-05 0.000237615

RAB39A ENSG00000179331 266.2872996 0.978261362 1.56E-05 0.000238179 USP15 ENSG00000135655 30184.1012 0.562673401 1.57E-05 0.000239924 XYLT2 ENSG00000015532 2164.285752 -0.456287704 1.58E-05 0.000240717 PALLD ENSG00000129116 2185.690368 0.889039528 1.59E-05 0.000241234 ABI2 ENSG00000138443 2181.641642 -0.783398355 1.59E-05 0.000241741 IMPAD1 ENSG00000104331 5910.687311 0.475547248 1.60E-05 0.000242458 FBXO7 ENSG00000100225 14053.82429 0.5137983 1.60E-05 0.000243528 MRPL47 ENSG00000136522 1578.785204 0.367565885 1.61E-05 0.000244959 TNPO3 ENSG00000064419 6219.373865 0.321964184 1.64E-05 0.000247578 ZFP92 ENSG00000189420 471.8093866 0.981547892 1.65E-05 0.000248746 TET2 ENSG00000168769 10402.45385 0.687370679 1.66E-05 0.00024993 ZBTB10 ENSG00000205189 1178.298447 0.744917158 1.66E-05 0.000250317 HTR1F ENSG00000179097 28.06326831 1.637808964 1.66E-05 0.000250655 STK38 ENSG00000112079 28496.24564 -0.396267794 1.67E-05 0.000251132 STXBP4 ENSG00000166263 427.7021781 -0.723085616 1.67E-05 0.000251556 CUL3 ENSG00000036257 7532.780446 0.444920129 1.67E-05 0.00025168 GNG12 ENSG00000172380 6.715428942 2.014685131 1.70E-05 0.000255126 SEC63 ENSG00000025796 9190.465524 0.385911006 1.70E-05 0.0002553 TCEB3 ENSG00000011007 4188.094513 0.498233575 1.71E-05 0.000255864 ORC5 ENSG00000164815 769.3830839 -0.434674817 1.71E-05 0.000255864 CFAP157 ENSG00000160401 34.39038488 -0.774401389 1.71E-05 0.000255864 VPS50 ENSG00000004766 1921.660792 -0.41505487 1.71E-05 0.000256475 AQP3 ENSG00000165272 2244.165658 -0.686178113 1.72E-05 0.000257422 ANKH ENSG00000154122 4762.850612 -0.463414183 1.72E-05 0.000257422 FAHD2B ENSG00000144199 385.9214154 -0.69790104 1.73E-05 0.000257717 ABCC10 ENSG00000124574 2902.540735 -0.411955228 1.73E-05 0.000258378 ENC1 ENSG00000171617 4173.772157 1.063275397 1.73E-05 0.000258451 SEMA3C ENSG00000075223 952.2746875 0.900409309 1.73E-05 0.000258451 FAM183BP ENSG00000164556 167.2767764 1.192295436 1.74E-05 0.0002593 TMEM177 ENSG00000144120 412.4285511 -0.784726944 1.75E-05 0.000260485 ADCK5 ENSG00000173137 707.8500906 -0.480072 1.76E-05 0.000261664 COL5A1 ENSG00000130635 44.5438034 -1.393980249 1.76E-05 0.000261883 RP1-122P22.4 ENSG00000268628 18.19325251 1.472255228 1.78E-05 0.000263417 CTD-2162K18.4 ENSG00000267260 14.58468411 -1.893060351 1.79E-05 0.000264242 PLXNA3 ENSG00000130827 3539.690222 -0.766377715 1.79E-05 0.000264549 ZNF283 ENSG00000167637 586.4271645 -0.567879061 1.79E-05 0.000264549 TET3 ENSG00000187605 10773.93649 0.723783697 1.79E-05 0.000264839 C11orf68 ENSG00000175573 1441.257147 -0.574557022 1.79E-05 0.000264839 FAM213A ENSG00000122378 453.4321759 -0.628016446 1.81E-05 0.000266378 CD44 ENSG00000026508 45886.30297 0.484930593 1.81E-05 0.000266378 RALGDS ENSG00000160271 9222.210383 -0.552010149 1.81E-05 0.000266571 TIGD2 ENSG00000180346 344.0404662 -0.602702748 1.83E-05 0.000269746 MYO5A ENSG00000197535 9837.457434 0.47066428 1.85E-05 0.000271579 STARD13 ENSG00000133121 74.35121016 1.203488698 1.85E-05 0.000271671 SAMD9 ENSG00000205413 4989.054377 -0.793983167 1.85E-05 0.000271756 DTYMK ENSG00000168393 1336.424378 -0.539502871 1.86E-05 0.000272873

ABCG1 ENSG00000160179 2169.081685 0.865548987 1.88E-05 0.000275093 WAS ENSG00000015285 17254.45681 0.378936299 1.88E-05 0.000275218 DNAJC2 ENSG00000105821 3998.551559 0.331433329 1.89E-05 0.00027614 ZNF397 ENSG00000186812 1906.04203 -0.695173332 1.90E-05 0.00027713 POLR2H ENSG00000163882 1247.409817 -0.544051665 1.93E-05 0.000280854 TRAF2 ENSG00000127191 1318.702505 -0.560656222 1.94E-05 0.000282253 SH3D19 ENSG00000109686 72.65591063 1.080731804 1.96E-05 0.000284424 KHSRP ENSG00000088247 6971.009093 0.187365852 1.96E-05 0.000284711 NUP210L ENSG00000143552 23.27976441 -1.188853771 1.96E-05 0.000284825 AURKB ENSG00000178999 206.5594366 0.990610436 1.97E-05 0.000286216 GAS1 ENSG00000180447 38.03698898 -1.262188564 1.98E-05 0.000286855 NAT10 ENSG00000135372 3706.327122 -0.287165608 2.00E-05 0.00029026 CCR8 ENSG00000179934 26.55971336 -1.511703601 2.03E-05 0.000293503 TBC1D20 ENSG00000125875 3888.166006 -0.420045652 2.03E-05 0.000293503 E2F2 ENSG00000007968 1479.167651 1.024521149 2.03E-05 0.000293503 NUCB1 ENSG00000104805 14121.02305 0.42146321 2.04E-05 0.000295162 MAGEE1 ENSG00000198934 529.1262925 -0.879022867 2.04E-05 0.000295162 AC129492.6 ENSG00000214999 62.16421243 -1.241734071 2.06E-05 0.000296804 LCMT2 ENSG00000168806 246.0771064 -0.964934596 2.07E-05 0.000298181 HIC1 ENSG00000177374 1334.919259 1.664607412 2.07E-05 0.000298959 PPM1A ENSG00000100614 7784.830894 0.492006406 2.08E-05 0.000299633 GNAZ ENSG00000128266 374.3989993 -0.98231729 2.08E-05 0.000299633 ALOX15B ENSG00000179593 313.3334777 1.827596234 2.09E-05 0.000300901 FRMD4B ENSG00000114541 1961.13604 0.684951652 2.09E-05 0.000300975 BROX ENSG00000162819 5664.934646 0.371667847 2.09E-05 0.000301019 CARMIL2 ENSG00000159753 5087.827943 -0.694429343 2.11E-05 0.000303268 CAT ENSG00000121691 13902.21312 0.618295468 2.11E-05 0.000303481 ATP6AP2 ENSG00000182220 7806.09551 0.752475442 2.12E-05 0.000303747 HLTF ENSG00000071794 879.0166173 -0.564385415 2.12E-05 0.000304012 ZNF599 ENSG00000153896 380.5298623 -0.734482975 2.14E-05 0.000306827 KLHL34 ENSG00000185915 24.45263694 -1.495199509 2.15E-05 0.000307159 HADHA ENSG00000084754 21151.80139 0.409672834 2.18E-05 0.000312134 ACTR1B ENSG00000115073 4213.228884 -0.342344138 2.21E-05 0.00031582 SIKE1 ENSG00000052723 3180.484281 -0.328317967 2.23E-05 0.00031759 PDZD8 ENSG00000165650 3564.879681 1.066837398 2.28E-05 0.000324332 SPPL2A ENSG00000138600 5264.440895 0.354306434 2.29E-05 0.000325278 R3HDM1 ENSG00000048991 3584.651988 0.281839557 2.30E-05 0.000326103 NUP58 ENSG00000139496 4389.395017 0.438609875 2.30E-05 0.000326334 TBC1D4 ENSG00000136111 6212.2964 -0.68740957 2.32E-05 0.000328453 MATK ENSG00000007264 4430.849861 -0.899999184 2.33E-05 0.000329285 PSPN ENSG00000125650 147.4862849 -0.777811733 2.33E-05 0.000329346 DNAAF2 ENSG00000165506 481.9645484 -0.593227756 2.34E-05 0.00033048 CAMK2N1 ENSG00000162545 158.1382032 -1.023434853 2.34E-05 0.00033048 GIPC1 ENSG00000123159 1350.493583 -0.601519077 2.34E-05 0.00033048 MED11 ENSG00000161920 815.3569512 -0.55825329 2.39E-05 0.00033713 AVPI1 ENSG00000119986 262.7737095 1.152935828 2.46E-05 0.000346323

DAXX ENSG00000204209 3695.959585 -0.48558178 2.47E-05 0.000347106 ZKSCAN4 ENSG00000187626 433.466545 -0.639543196 2.48E-05 0.000348505 CD3D ENSG00000167286 7043.300031 -0.870952405 2.50E-05 0.000350615 ADGRE5 ENSG00000123146 38962.6677 0.438802021 2.51E-05 0.000351998 GLS2 ENSG00000135423 80.23751753 -1.183823251 2.51E-05 0.000352259 RASSF1 ENSG00000068028 10997.706 -0.771360762 2.53E-05 0.00035439 IL7 ENSG00000104432 108.9312236 -0.838477663 2.54E-05 0.000355887 ZC3H7A ENSG00000122299 8423.95924 0.468192463 2.57E-05 0.000359246 GDPD1 ENSG00000153982 165.0091255 -0.677185027 2.58E-05 0.000360226 PIP5K1B ENSG00000107242 589.2461691 0.660766016 2.60E-05 0.000363463 MRC1 ENSG00000260314 409.7969065 1.413584609 2.61E-05 0.000364618 SALL2 ENSG00000165821 158.8847827 -1.073243862 2.61E-05 0.000364618 PRPF19 ENSG00000110107 4818.680917 -0.402814438 2.66E-05 0.000370268 SNRNP70 ENSG00000104852 15964.93636 -0.291460029 2.70E-05 0.000374092 ZNF790 ENSG00000197863 201.4054702 -0.610522605 2.71E-05 0.000374936 AMPH ENSG00000078053 301.4182006 1.717617303 2.71E-05 0.000375697 IPO13 ENSG00000117408 2003.832242 -0.450984722 2.73E-05 0.000377623 MITD1 ENSG00000158411 2530.538688 -0.500654366 2.74E-05 0.000378249 FBXL5 ENSG00000118564 28339.36044 0.569534309 2.75E-05 0.000378956 DDHD2 ENSG00000085788 4090.702988 -0.362392511 2.75E-05 0.000379561 LRIF1 ENSG00000121931 809.6992142 -0.567968025 2.76E-05 0.000380745 CTNNAL1 ENSG00000119326 240.5066304 0.981036675 2.80E-05 0.000384872 CRAT ENSG00000095321 1467.619819 0.36553709 2.80E-05 0.000385041 SLC8A1 ENSG00000183023 2985.423399 0.895515784 2.82E-05 0.000386999 SLC37A4 ENSG00000137700 700.6073363 -0.432409571 2.83E-05 0.000388448 ARHGEF40 ENSG00000165801 5695.987917 0.76432216 2.84E-05 0.000389682 ANXA11 ENSG00000122359 18560.38425 0.41074911 2.85E-05 0.000390341 FGD3 ENSG00000127084 21972.40486 -0.354416868 2.87E-05 0.00039335 VPS8 ENSG00000156931 5372.562464 0.37837885 2.88E-05 0.000394115 YTHDF1 ENSG00000149658 5437.821649 0.315534282 2.89E-05 0.000394452 BTG3 ENSG00000154640 1028.535208 0.790811398 2.90E-05 0.000395795 CDC42BPB ENSG00000198752 2810.101025 0.474130852 2.91E-05 0.00039645 RASGRP4 ENSG00000171777 6024.33174 0.669282461 2.92E-05 0.000398314 BCL2L11 ENSG00000153094 4445.007646 1.198228053 2.94E-05 0.00040068 COPS7B ENSG00000144524 3220.616032 -0.320123679 2.94E-05 0.000401206 ARPC2 ENSG00000163466 48522.48244 0.347821366 2.95E-05 0.000401615 GCA ENSG00000115271 14707.29058 0.97600209 2.95E-05 0.000401615 DOCK4 ENSG00000128512 517.5665172 0.982556494 2.97E-05 0.000403411 NSMCE2 ENSG00000156831 1075.035456 0.309680479 2.99E-05 0.000405976 MAP3K3 ENSG00000198909 14418.32771 0.549675003 3.00E-05 0.000407223 P4HB ENSG00000185624 24903.55964 0.481219683 3.01E-05 0.000407644 OSER1 ENSG00000132823 8359.578305 0.591404499 3.06E-05 0.000413436 PRIMPOL ENSG00000164306 980.4920032 -0.481733078 3.09E-05 0.000416435 SGTB ENSG00000197860 3685.509402 0.492838885 3.10E-05 0.000417886 IL4 ENSG00000113520 23.11144227 -1.77412543 3.10E-05 0.000417994 TMC3 ENSG00000188869 15.901005 1.493293823 3.12E-05 0.000420209

TRMT2B ENSG00000188917 2952.445201 -0.363738662 3.12E-05 0.000420209 RREB1 ENSG00000124782 4375.529778 0.540000553 3.13E-05 0.000420324 ELMO1 ENSG00000155849 4594.826865 0.334789926 3.15E-05 0.000423809 CUEDC1 ENSG00000180891 1394.699768 0.575328535 3.16E-05 0.000423901 ATOH8 ENSG00000168874 165.4053577 1.486094936 3.19E-05 0.00042606 LRRK1 ENSG00000154237 3078.204635 0.607344429 3.18E-05 0.00042606 FUCA1 ENSG00000179163 3063.340439 0.861735041 3.18E-05 0.00042606 MPHOSPH8 ENSG00000196199 7906.963584 -0.401060734 3.19E-05 0.00042606 ADGRB2 ENSG00000121753 211.8375653 -1.111084855 3.18E-05 0.00042606 SEC61B ENSG00000106803 3153.307006 0.440089503 3.20E-05 0.000427372 HIST1H4H ENSG00000158406 262.1118569 0.638183409 3.20E-05 0.000427372 CLTA ENSG00000122705 4478.864089 0.492122837 3.22E-05 0.000429479 CYBB ENSG00000165168 86442.26215 0.831083919 3.23E-05 0.000430041 PLBD2 ENSG00000151176 3545.766638 0.588575802 3.25E-05 0.000432815 PPFIBP2 ENSG00000166387 1652.606919 0.506831009 3.26E-05 0.00043343 ARSK ENSG00000164291 344.4116889 -0.723669573 3.29E-05 0.000437515 MAP4K2 ENSG00000168067 5611.407623 -0.296195558 3.32E-05 0.000440536 BAHCC1 ENSG00000266074 637.1676932 0.813556885 3.32E-05 0.000440631 SPPL3 ENSG00000157837 2558.184606 0.314051094 3.35E-05 0.000442836 FAR1 ENSG00000197601 12882.27345 0.515096503 3.39E-05 0.000447427 BNIP3 ENSG00000176171 1332.676463 -0.448214014 3.40E-05 0.000448703 OLIG1 ENSG00000184221 403.2662423 -0.98191748 3.42E-05 0.000450088 ZNF345 ENSG00000251247 775.7454452 -0.809681384 3.43E-05 0.000451715 PGK1 ENSG00000102144 31750.18125 0.418689668 3.44E-05 0.000452211 CDC14B ENSG00000081377 835.0786981 -0.70688909 3.45E-05 0.000453593 C11orf63 ENSG00000109944 322.4492931 -0.749080879 3.47E-05 0.000455769 ZBTB16 ENSG00000109906 3585.964498 1.486971389 3.51E-05 0.000461077 GIMAP8 ENSG00000171115 3603.416681 -0.803182153 3.53E-05 0.000462757 CAPNS1 ENSG00000126247 16379.73539 0.508155616 3.54E-05 0.000463508 GLA ENSG00000102393 1967.476536 0.497196247 3.57E-05 0.000466603 TRMT12 ENSG00000183665 667.7400443 -0.528858271 3.57E-05 0.000466603 IVD ENSG00000128928 2993.523571 -0.578032374 3.59E-05 0.00046821 MUTYH ENSG00000132781 1118.072151 -0.4191274 3.59E-05 0.000468602 SLC35B1 ENSG00000121073 2291.718192 0.44550802 3.61E-05 0.000470386 FAM122A ENSG00000187866 1534.932045 -0.448281624 3.61E-05 0.000470771 SFPQ ENSG00000116560 23159.77949 0.47356682 3.65E-05 0.000475084 PRX ENSG00000105227 390.6466706 -0.521515841 3.66E-05 0.000475708 RAB29 ENSG00000117280 5806.698856 -0.59893669 3.69E-05 0.000479556 FAM129B ENSG00000136830 4607.28335 0.697307525 3.69E-05 0.000479714 ZNF485 ENSG00000198298 197.5812771 -0.94228605 3.72E-05 0.000482353 ARL5B ENSG00000165997 4256.781058 0.82065084 3.75E-05 0.000486182 SLC2A9 ENSG00000109667 1433.401309 0.673840207 3.76E-05 0.000487189 RAB9B ENSG00000123570 49.84349756 -1.016145593 3.77E-05 0.000487588 NR4A2 ENSG00000153234 3874.115516 1.060588543 3.81E-05 0.000492383 NCF2 ENSG00000116701 50644.27876 0.599569691 3.82E-05 0.000493171 SAV1 ENSG00000151748 55.13764643 1.030660386 3.82E-05 0.000493191

PTGFR ENSG00000122420 52.87636952 1.716051969 3.84E-05 0.000495136 RBM22 ENSG00000086589 7570.033289 0.316756279 3.85E-05 0.000496781 AHSA1 ENSG00000100591 3950.567426 -0.471167206 3.86E-05 0.000497392 DNASE1L3 ENSG00000163687 81.24504007 -1.674266865 3.86E-05 0.000497433 LIPN ENSG00000204020 617.936739 0.923743513 3.91E-05 0.000503578 MAFK ENSG00000198517 2182.466461 0.633393844 3.92E-05 0.000503578 ACPP ENSG00000014257 2986.180021 0.77493915 3.92E-05 0.000503578 PDGFD ENSG00000170962 852.0269023 -0.952248987 3.94E-05 0.000505473 RP2 ENSG00000102218 3955.49006 0.639661716 3.98E-05 0.000509817 CTSF ENSG00000174080 841.1257332 -0.738357099 3.98E-05 0.000509817 RBPJ ENSG00000168214 9359.26953 0.854190011 4.10E-05 0.000523343 COQ10B ENSG00000115520 2321.531793 0.628959505 4.12E-05 0.00052572 TCTEX1D1 ENSG00000152760 138.2823099 1.506081462 4.13E-05 0.000526826 LSM4 ENSG00000130520 3124.585696 -0.588114645 4.16E-05 0.000529706 C4orf19 ENSG00000154274 117.5227076 1.229217623 4.17E-05 0.000531077 CD34 ENSG00000174059 53.70819279 -1.524705622 4.19E-05 0.000532162 ERLIN2 ENSG00000147475 2619.11893 0.438692572 4.22E-05 0.000535377 POP5 ENSG00000167272 1344.247451 -0.478767406 4.23E-05 0.000535979 CAPZB ENSG00000077549 21492.63782 0.35452626 4.24E-05 0.000536877 HBP1 ENSG00000105856 6949.499281 0.646925197 4.24E-05 0.000536877 MEGF9 ENSG00000106780 23280.68926 1.268723003 4.25E-05 0.000537674 INTS12 ENSG00000138785 1604.430545 0.313896464 4.31E-05 0.000544688 NAF1 ENSG00000145414 872.2933848 0.405688142 4.34E-05 0.000548979 MCM8 ENSG00000125885 715.9845073 -0.734697887 4.37E-05 0.000551638 PRKACB ENSG00000142875 7988.038705 -0.50057576 4.39E-05 0.000553425 UBE2E3 ENSG00000170035 3416.561269 0.311272823 4.41E-05 0.000556093 KIF5B ENSG00000170759 11793.53091 0.34009795 4.43E-05 0.000557975 PHKB ENSG00000102893 6866.451874 0.366392794 4.43E-05 0.000557975 PPP1R2 ENSG00000184203 9436.021488 0.353398424 4.44E-05 0.000558251 C1orf56 ENSG00000143443 207.8710369 -0.554415898 4.44E-05 0.000558609 IL1R1 ENSG00000115594 1853.134713 1.430956952 4.44E-05 0.000558609 HSD17B7 ENSG00000132196 1160.560048 -0.374023491 4.47E-05 0.00056142 DFFA ENSG00000160049 1947.003185 -0.47433115 4.47E-05 0.00056142 GHITM ENSG00000165678 14212.03819 0.297444152 4.48E-05 0.00056197 TMEM186 ENSG00000184857 432.4001287 -0.823922616 4.50E-05 0.00056394 FAM151B ENSG00000152380 494.4541659 1.033459793 4.51E-05 0.000564835 TFEC ENSG00000105967 5556.598552 0.75258235 4.52E-05 0.00056558 FCHO2 ENSG00000157107 2617.757912 0.795003717 4.56E-05 0.000569841 PP2D1 ENSG00000183977 332.6180869 0.618794497 4.57E-05 0.000570142 DEDD ENSG00000158796 3691.833304 0.460399365 4.58E-05 0.000571001 ABCA7 ENSG00000064687 12033.75892 -0.400178786 4.61E-05 0.000575118 MIEF2 ENSG00000177427 287.6091298 -0.728570511 4.63E-05 0.000576758 STK25 ENSG00000115694 4898.829009 -0.307948817 4.63E-05 0.000576758 SP4 ENSG00000105866 2267.689466 -0.554875459 4.66E-05 0.000579526 DZIP1L ENSG00000158163 156.3389193 1.186126715 4.68E-05 0.000582628 DUOX1 ENSG00000137857 140.8269425 -0.651609941 4.69E-05 0.000583312

RPS6KA5 ENSG00000100784 2152.442491 -0.438268885 4.71E-05 0.00058536 RXRB ENSG00000204231 5228.497811 -0.294073112 4.75E-05 0.000589005 MED30 ENSG00000164758 2489.070046 0.595252002 4.77E-05 0.00059063 KIF20A ENSG00000112984 124.6007721 1.209203853 4.80E-05 0.000593696 SEC13 ENSG00000157020 4326.736157 0.302986682 4.80E-05 0.000593696 GOLGA7B ENSG00000155265 1003.934885 -0.90975487 4.82E-05 0.000595404 HDAC7 ENSG00000061273 8790.093756 -0.381544961 4.86E-05 0.000599968 ITPRIPL1 ENSG00000198885 852.4672016 -0.843082385 4.86E-05 0.000600009 SLC22A4 ENSG00000197208 2008.214245 0.975101964 4.88E-05 0.000602233 IRF3 ENSG00000126456 6858.819247 -0.443938402 4.92E-05 0.000605393 NIPSNAP3A ENSG00000136783 1934.251514 0.475418597 4.95E-05 0.000608568 NUSAP1 ENSG00000137804 934.534661 0.996102044 4.98E-05 0.000610952 LARGE2 ENSG00000165905 498.7594709 -0.965198118 4.97E-05 0.000610952 PI16 ENSG00000164530 267.1385697 -1.1815343 5.02E-05 0.000615624 TMEM116 ENSG00000198270 1406.210141 -0.486147891 5.05E-05 0.000618614 DHX16 ENSG00000204560 5141.917263 -0.285778961 5.07E-05 0.000620624 ZNF687 ENSG00000143373 4433.507356 0.593720816 5.10E-05 0.00062355 RAB2A ENSG00000104388 5561.000828 0.422173548 5.11E-05 0.000624595 SLC35D2 ENSG00000130958 1663.146628 0.49654884 5.12E-05 0.000625488 CALHM2 ENSG00000138172 2477.269572 -0.824920833 5.15E-05 0.000628108 ANXA5 ENSG00000164111 20703.75 0.533796997 5.16E-05 0.000628725 CAPRIN2 ENSG00000110888 3114.480647 -0.423086725 5.20E-05 0.00063256 CRNKL1 ENSG00000101343 2994.606841 0.430733044 5.20E-05 0.000632977 SUPV3L1 ENSG00000156502 2696.66054 0.661248301 5.23E-05 0.000635527 EVL ENSG00000196405 28001.49594 -0.617579517 5.25E-05 0.000637924 KLC2 ENSG00000174996 1656.900354 -0.540807161 5.27E-05 0.000639541 NKD1 ENSG00000140807 363.9678436 -0.771975551 5.28E-05 0.000639757 CYSTM1 ENSG00000120306 1552.060151 1.019724405 5.30E-05 0.00064205 CMB9-22P13.1 ENSG00000173727 36.46404259 -0.95631125 5.30E-05 0.000642218 ANKRD9 ENSG00000156381 376.1429657 1.06458709 5.33E-05 0.000645407 RALGAPA2 ENSG00000188559 6814.277279 0.567316174 5.35E-05 0.000648032 NRN1 ENSG00000124785 56.23697163 1.464046186 5.35E-05 0.000648032 TPX2 ENSG00000088325 557.7185287 1.091003239 5.41E-05 0.000653431 CTSH ENSG00000103811 12266.39009 0.551479844 5.41E-05 0.000653431 NR3C2 ENSG00000151623 1032.386549 -0.592961491 5.40E-05 0.000653431 TRIP13 ENSG00000071539 149.9111643 1.111851641 5.42E-05 0.000655055 FAM72C ENSG00000263513 132.9741371 1.042813593 5.43E-05 0.000655488 SMIM10 ENSG00000184785 70.15301534 1.261141083 5.56E-05 0.000669531 GADD45B ENSG00000099860 5303.805238 0.736454819 5.57E-05 0.000670943 ARRDC4 ENSG00000140450 3996.059026 0.80053614 5.58E-05 0.000671049 ZNF80 ENSG00000174255 221.2522526 -1.007676156 5.62E-05 0.000675566 GPR55 ENSG00000135898 564.7474462 -0.858814931 5.62E-05 0.000675773 CDKN2C ENSG00000123080 557.6363771 0.703378706 5.65E-05 0.00067857 NOSIP ENSG00000142546 5551.064037 -0.60633394 5.65E-05 0.000678651 FRMD3 ENSG00000172159 742.5900339 0.740920981 5.68E-05 0.00068177 MPI ENSG00000178802 2343.782387 -0.526485276 5.69E-05 0.000682195

FAM50B ENSG00000145945 178.665329 -0.726647574 5.69E-05 0.000682526 CRISPLD2 ENSG00000103196 2876.955263 0.937190914 5.71E-05 0.000683963 TMEM131 ENSG00000075568 8611.249698 0.431946191 5.71E-05 0.000684326 NUDT15 ENSG00000136159 729.0928255 0.368053721 5.74E-05 0.000686477 PSIP1 ENSG00000164985 9441.64829 -0.364254435 5.77E-05 0.000690128 TRAPPC6A ENSG00000007255 1054.983012 -0.59369124 5.78E-05 0.000690837 ADD2 ENSG00000075340 488.6993946 -0.803056652 5.79E-05 0.000692051 EPHB2 ENSG00000133216 463.2694027 0.995421316 5.82E-05 0.000694674 SEC24B ENSG00000138802 5587.626023 0.492702992 5.83E-05 0.000695904 IFT172 ENSG00000138002 1401.207367 -0.351467751 5.87E-05 0.000699406 SIMC1 ENSG00000170085 797.6113433 -0.312800953 5.88E-05 0.000700519 CAPG ENSG00000042493 9751.492053 0.631636682 5.93E-05 0.000706459 ERGIC1 ENSG00000113719 12629.80294 0.576055164 5.94E-05 0.000707544 GSTA4 ENSG00000170899 95.02953208 -0.778926097 5.98E-05 0.000712039 SARDH ENSG00000123453 312.137758 -0.878899811 5.98E-05 0.000712096 SASH1 ENSG00000111961 1543.317097 1.034413257 6.02E-05 0.000715709 BCLAF1 ENSG00000029363 15256.12362 0.492050901 6.05E-05 0.000718494 PADI2 ENSG00000117115 5140.147295 1.057073117 6.08E-05 0.000722314 TTC30B ENSG00000196659 140.6189242 -0.68630804 6.09E-05 0.000723301 USP6NL ENSG00000148429 2412.534167 0.676980727 6.14E-05 0.000728621 UBAP1L ENSG00000246922 1569.631301 -0.478147484 6.20E-05 0.000734483 LAMC1 ENSG00000135862 950.1237171 1.07186964 6.24E-05 0.000737738 MSH3 ENSG00000113318 1333.807101 0.482320082 6.24E-05 0.000737904 SYNPO2 ENSG00000172403 83.05775725 -0.978498902 6.25E-05 0.000738884 ELP3 ENSG00000134014 2229.822039 -0.454037913 6.27E-05 0.000740948 ZNF789 ENSG00000198556 1150.779348 -0.323870196 6.30E-05 0.000743619 HNRNPU ENSG00000153187 44912.38174 0.180323883 6.30E-05 0.000743619 DZIP3 ENSG00000198919 1643.406104 -0.455735528 6.31E-05 0.000743619 AZIN2 ENSG00000142920 218.3174083 -0.84829032 6.35E-05 0.000747842 TYMS ENSG00000176890 799.294041 1.043813882 6.36E-05 0.000748491 RNF11 ENSG00000123091 5138.329802 0.837753629 6.37E-05 0.000748737 VNN1 ENSG00000112299 2937.235802 1.101270194 6.38E-05 0.000749957 CHD1 ENSG00000153922 13384.50255 0.666412856 6.43E-05 0.000754635 IL7R ENSG00000168685 36486.29918 -0.646748469 6.44E-05 0.000755387 RP11-429E11.3 ENSG00000179253 47.46172892 -1.295565918 6.48E-05 0.00075999 UBE2A ENSG00000077721 5191.457822 0.36087388 6.52E-05 0.000763401 ZNF132 ENSG00000131849 101.4747848 -0.892499612 6.57E-05 0.000768651 SUMO1 ENSG00000116030 3748.310301 0.521403174 6.57E-05 0.000768651 IQGAP3 ENSG00000183856 116.283872 1.548605799 6.60E-05 0.000771429 RPL39L ENSG00000163923 120.3960758 -0.779616401 6.61E-05 0.000771429 HTRA2 ENSG00000115317 1500.956405 -0.505690363 6.61E-05 0.000771611 AC243756.1 ENSG00000270339 26.00335975 -1.452290094 6.63E-05 0.000773585 CCNK ENSG00000090061 3776.782324 0.430047359 6.64E-05 0.000773969 MTHFD2L ENSG00000163738 492.5596414 0.518400626 6.64E-05 0.000774227 PLEKHM2 ENSG00000116786 8218.264539 0.40998817 6.65E-05 0.000774511 GEMIN6 ENSG00000152147 462.9996172 -0.627794662 6.67E-05 0.000775976

OR5K2 ENSG00000231861 35.44555287 -1.133951678 6.68E-05 0.000777038 C11orf21 ENSG00000110665 8460.674014 -0.4761407 6.69E-05 0.000777112 FEZ2 ENSG00000171055 2177.99292 0.52191892 6.74E-05 0.000782315 MCU ENSG00000156026 2058.74332 0.808505711 6.75E-05 0.000783357 LAMA2 ENSG00000196569 113.7340158 -1.174249162 6.75E-05 0.000783357 TOR2A ENSG00000160404 1897.26703 0.414679238 6.75E-05 0.000783357 EIF4EBP1 ENSG00000187840 1753.965861 0.603843164 6.76E-05 0.000783523 CCDC151 ENSG00000198003 74.83617625 1.024117599 6.76E-05 0.000783523 ZNF138 ENSG00000197008 1273.342031 -0.628287224 6.82E-05 0.00078895 NDUFAF4 ENSG00000123545 517.2310802 -0.682391221 6.82E-05 0.000789477 SNX27 ENSG00000143376 6400.766546 0.515037999 6.89E-05 0.000796415 PLD1 ENSG00000075651 815.2946529 0.817690278 6.96E-05 0.000803875 TTC9C ENSG00000162222 1297.40342 -0.568678867 6.97E-05 0.00080462 MLF2 ENSG00000089693 7611.419959 0.417928773 6.98E-05 0.000805509 CDKN1A ENSG00000124762 5306.314688 1.089598934 7.00E-05 0.000805509 GPR157 ENSG00000180758 320.6744713 -0.663045715 6.99E-05 0.000805509 RAB3GAP1 ENSG00000115839 4001.396085 0.377052546 7.01E-05 0.000806951 BMT2 ENSG00000164603 2087.793333 0.429729408 7.05E-05 0.000810936 SIGLEC15 ENSG00000197046 345.2342423 0.906608687 7.09E-05 0.000815162 PARP1 ENSG00000143799 9434.527016 -0.472014706 7.10E-05 0.000815845 CENPU ENSG00000151725 399.2420118 0.900274971 7.11E-05 0.000817237 MIS18A ENSG00000159055 337.730547 -0.473652324 7.20E-05 0.000826791 RFX5 ENSG00000143390 6572.206132 -0.300730874 7.25E-05 0.000831579 WDFY2 ENSG00000139668 4013.116622 0.511539483 7.29E-05 0.000835144 RIMS3 ENSG00000117016 343.9431591 -0.559227515 7.35E-05 0.000839501 LAMTOR5 ENSG00000134248 3145.727581 0.478091056 7.39E-05 0.000842883 JAKMIP1 ENSG00000152969 1389.473129 -0.78459663 7.41E-05 0.000844272 CYP20A1 ENSG00000119004 2024.620458 -0.452368132 7.41E-05 0.000844272 CCDC124 ENSG00000007080 2294.272721 0.469605035 7.42E-05 0.000845086 ANOS1 ENSG00000011201 29.27408022 1.586046696 7.51E-05 0.000855164 FAM43A ENSG00000185112 286.0405468 -0.838700805 7.55E-05 0.000858615 QKI ENSG00000112531 5605.674672 0.675882272 7.58E-05 0.000860955 SCAF11 ENSG00000139218 5011.66527 0.503474317 7.59E-05 0.000861923 SERBP1 ENSG00000142864 14470.67483 0.231920648 7.61E-05 0.000863744 REEP4 ENSG00000168476 2209.262906 0.474998312 7.61E-05 0.000863744 SRGAP2 ENSG00000266028 6884.352336 0.554054176 7.64E-05 0.000865939 RTCA ENSG00000137996 3452.594412 0.438676177 7.64E-05 0.000865939 SLC24A4 ENSG00000140090 5664.23087 0.963701391 7.65E-05 0.000866664 C3orf52 ENSG00000114529 181.8701426 -0.786323216 7.72E-05 0.000873631 MT-ND3 ENSG00000198840 73719.56097 0.45197219 7.75E-05 0.000876923 CCDC6 ENSG00000108091 3938.010179 0.570614639 7.76E-05 0.00087815 GABARAPL1 ENSG00000139112 3655.392399 0.921242273 7.78E-05 0.000879832 RER1 ENSG00000157916 10502.81246 -0.356990039 7.82E-05 0.000883089 TMEM45A ENSG00000181458 65.21685699 1.741933413 7.84E-05 0.000885468 DICER1 ENSG00000100697 9488.115837 0.6005559 7.85E-05 0.00088633 ICAM2 ENSG00000108622 3525.846414 -0.620705182 7.87E-05 0.000886978

TPRG1L ENSG00000158109 4249.338891 -0.32398843 7.92E-05 0.000891566 PDCD11 ENSG00000148843 3237.92897 -0.293069557 7.93E-05 0.000891566 QPCT ENSG00000115828 3324.243786 0.76565125 7.98E-05 0.000896899 ZNF420 ENSG00000197050 446.0110403 -0.857207454 7.99E-05 0.000897807 RPA2 ENSG00000117748 3638.390847 -0.375682349 8.02E-05 0.000900681 RAB12 ENSG00000206418 6432.317888 0.453778086 8.05E-05 0.000903715 USP5 ENSG00000111667 4103.270371 -0.385875154 8.15E-05 0.000914255 TBX21 ENSG00000073861 6197.763781 -0.960671079 8.18E-05 0.00091721 NPTXR ENSG00000221890 580.628853 -0.875095214 8.25E-05 0.00092484 ACSF2 ENSG00000167107 1149.87934 -0.326822484 8.26E-05 0.000924996 CA14 ENSG00000118298 136.624682 0.726186901 8.30E-05 0.000928342 HNMT ENSG00000150540 2059.40285 0.638704918 8.30E-05 0.000928342 VAT1 ENSG00000108828 3068.741821 0.565071285 8.31E-05 0.000929032 STRN4 ENSG00000090372 5714.555055 0.428094311 8.32E-05 0.000930192 MTMR6 ENSG00000139505 5003.517853 0.596161508 8.33E-05 0.000930661 C12orf65 ENSG00000130921 649.5580316 -0.499353231 8.36E-05 0.000933008 PGS1 ENSG00000087157 4260.153142 0.649626878 8.43E-05 0.000940395 BCCIP ENSG00000107949 3284.728059 0.252385425 8.46E-05 0.000943406 PLEKHF2 ENSG00000175895 5007.71681 0.311982123 8.54E-05 0.000951519 MTG2 ENSG00000101181 1927.456053 -0.438094421 8.56E-05 0.00095327 COL6A2 ENSG00000142173 3868.361299 -0.935505418 8.62E-05 0.000958558 PITPNA ENSG00000174238 7559.784587 0.427198538 8.71E-05 0.000968033 HMGN2 ENSG00000198830 15918.46842 0.462185958 8.72E-05 0.000968403 MARCH6 ENSG00000145495 11954.88619 0.50463672 8.72E-05 0.000968452 TJP3 ENSG00000105289 307.7701973 -0.921349433 8.73E-05 0.000969022 TMEM81 ENSG00000174529 168.4553548 -0.706293717 8.77E-05 0.000972743 ZNF578 ENSG00000258405 105.7966994 -0.932127606 8.80E-05 0.000975994 CDK5R1 ENSG00000176749 983.3885259 0.7601845 8.86E-05 0.000980991 SLC10A7 ENSG00000120519 808.2883635 0.409284988 8.88E-05 0.000982867 WNT10A ENSG00000135925 117.8765265 -0.987430749 8.96E-05 0.00099095 PCTP ENSG00000141179 1927.289327 0.529107215 8.98E-05 0.000992514 ARG1 ENSG00000118520 1453.34666 1.522820034 9.00E-05 0.000993381 NFIA ENSG00000162599 449.4589573 1.117489909 9.01E-05 0.000994785 MYDGF ENSG00000074842 3531.769625 0.707004394 9.03E-05 0.000996379 ZYX ENSG00000159840 32028.97239 0.512501878 9.05E-05 0.00099813 RDX ENSG00000137710 1544.363804 0.37193822 9.07E-05 0.001000526 DHX57 ENSG00000163214 2930.259428 0.348760497 9.14E-05 0.001007155 SELENOK ENSG00000113811 3085.514579 0.602428367 9.15E-05 0.00100785 CCHCR1 ENSG00000204536 1218.81134 -0.39721421 9.18E-05 0.001010482 UBTF ENSG00000108312 10972.26237 -0.339860985 9.21E-05 0.0010123 ANKRD34B ENSG00000189127 399.0118615 1.145901214 9.22E-05 0.001013843 OAT ENSG00000065154 3621.97465 0.425364309 9.23E-05 0.001014398 XCL1 ENSG00000143184 217.6768263 -1.033574382 9.27E-05 0.001017567 SUMF1 ENSG00000144455 2296.581538 0.459626117 9.35E-05 0.001025661 TGM4 ENSG00000163810 122.8561981 0.62712831 9.40E-05 0.001030893 VAMP7 ENSG00000124333 1866.920802 0.908355989 9.46E-05 0.00103725

LPAR1 ENSG00000198121 807.0252367 0.810754964 9.48E-05 0.001038639 ZNF665 ENSG00000197497 134.2929594 -0.796465159 9.48E-05 0.001038763 ACBD4 ENSG00000181513 1631.734882 -0.572813955 9.53E-05 0.001043608 PADI4 ENSG00000159339 8696.826409 0.935780755 9.54E-05 0.001044006 FAM32A ENSG00000105058 6594.682371 0.332446926 9.57E-05 0.001047288 SLC25A13 ENSG00000004864 1802.024889 0.472854903 9.63E-05 0.001050623 ZNF106 ENSG00000103994 13127.9033 0.477766028 9.64E-05 0.00105167 EVA1B ENSG00000142694 264.339883 0.686250585 9.81E-05 0.001066521 RELA ENSG00000173039 7780.646802 0.441626358 9.82E-05 0.001067334 TREML4 ENSG00000188056 460.950176 1.241586607 9.84E-05 0.001069441 LRRC25 ENSG00000175489 10480.34889 0.589617589 9.84E-05 0.001069441 CD3E ENSG00000198851 16588.1932 -0.656997541 9.86E-05 0.001070641 ATP6AP1 ENSG00000071553 9059.016837 0.43490701 9.87E-05 0.001071857 RNF40 ENSG00000103549 6586.602416 0.37297293 9.90E-05 0.001073653 ERO1A ENSG00000197930 8644.066459 0.392736309 9.89E-05 0.001073653 POR ENSG00000127948 4628.769618 0.416066963 9.93E-05 0.001076355 TP53BP2 ENSG00000143514 4179.229351 0.557809961 0.000100225 0.001085639 LOXHD1 ENSG00000167210 843.2685731 1.226798577 0.00010067 0.001090051 DOCK5 ENSG00000147459 6644.386743 0.75458776 0.000101281 0.00109544 KRBOX4 ENSG00000147121 1047.065013 -0.540522566 0.000101271 0.00109544 SIGLEC12 ENSG00000254521 564.1043768 1.611402724 0.000101219 0.00109544 C5orf30 ENSG00000181751 914.1209611 1.169353284 0.000101717 0.001098913 TXN ENSG00000136810 3666.456872 0.548209945 0.000102923 0.001110288 LAS1L ENSG00000001497 3602.767616 -0.255022326 0.000103214 0.001113006 SCAP ENSG00000114650 5707.998807 -0.240393537 0.000103394 0.001114117 MITF ENSG00000187098 529.0434079 0.769044588 0.000103521 0.001114659 HEMK1 ENSG00000114735 3559.847586 -0.704361082 0.000104692 0.00112475 ERC1 ENSG00000082805 1201.020583 0.666334222 0.000104839 0.001125516 COLGALT2 ENSG00000198756 521.8973802 -0.876895704 0.000104841 0.001125516 THOC3 ENSG00000051596 1395.980272 -0.44790744 0.000105451 0.001131217 MORC4 ENSG00000133131 342.1034184 -0.587707367 0.00010565 0.001132924 KCNN4 ENSG00000104783 2017.973788 -0.577953714 0.00010575 0.00113316 CLEC7A ENSG00000172243 16706.33853 0.927854936 0.000106135 0.001136864 LIN9 ENSG00000183814 264.7097456 -0.629567208 0.000106203 0.001137173 HSPA12B ENSG00000132622 234.9428416 0.941018932 0.000106509 0.001140033 BCL7B ENSG00000106635 3473.041658 0.406231357 0.000106578 0.001140258 ANKRD22 ENSG00000152766 422.7653055 1.143273029 0.000106609 0.001140258 KDELR1 ENSG00000105438 4845.846301 0.505384564 0.000106726 0.00114108 BAG5 ENSG00000166170 4118.163963 0.362918676 0.000107473 0.001148221 EMD ENSG00000102119 2186.158113 0.413297048 0.000107847 0.001150988 ZFP82 ENSG00000181007 368.1637361 -0.729456217 0.000107964 0.001151767 LCP1 ENSG00000136167 186268.4373 0.394212251 0.000110582 0.001175779 RNF144A ENSG00000151692 1720.901519 -0.728004701 0.000111385 0.001183882 DIMT1 ENSG00000086189 3796.922701 -0.452677364 0.000111553 0.001185239 RGS17 ENSG00000091844 118.0672817 -0.993058534 0.000111666 0.001186 C18orf54 ENSG00000166845 249.4158032 -0.521737612 0.000111806 0.001187046

MT1E ENSG00000169715 197.6599592 1.05740368 0.000112225 0.001190621 RHOG ENSG00000177105 12160.38776 0.631167985 0.000113139 0.001199438 RRP1B ENSG00000160208 3943.338942 -0.345927919 0.000113255 0.001200229 TOP3B ENSG00000100038 2331.457762 -0.370132965 0.000113817 0.001204864 ZNF491 ENSG00000177599 143.7373541 -0.618922558 0.000114073 0.001207128 NECTIN3 ENSG00000177707 92.31601028 -0.763867462 0.000114254 0.001208596 PLXNC1 ENSG00000136040 11131.05657 0.829705337 0.000114674 0.001212153 C1orf123 ENSG00000162384 1647.994942 -0.378850132 0.00011481 0.001212699 NCOA3 ENSG00000124151 9440.430891 0.571305282 0.000115166 0.001215145 UBE2C ENSG00000175063 186.359153 1.139846137 0.00011525 0.001215578 RP1-241P17.4 ENSG00000228532 124.5840196 0.370404329 0.000115755 0.001220458 SCFD1 ENSG00000092108 5850.347015 0.450089378 0.000118115 0.001242459 PDE4B ENSG00000184588 8301.407579 0.635775642 0.000118493 0.001245689 CHST13 ENSG00000180767 281.5205635 0.771216352 0.00011866 0.001246989 SERINC1 ENSG00000111897 15879.35694 0.44151947 0.000119401 0.001253648 PSD4 ENSG00000125637 17073.79902 -0.414207583 0.00011992 0.001258392 GJB6 ENSG00000121742 60.68029027 1.491623682 0.000120751 0.001265734 CCDC114 ENSG00000105479 106.6434774 -0.873300626 0.000121034 0.001267327 EMC6 ENSG00000127774 746.7987352 0.526057935 0.000121143 0.001267882 CLK2 ENSG00000176444 7097.609936 -0.257064469 0.000121414 0.001269923 ZNF623 ENSG00000183309 2236.184844 -0.634810892 0.000122069 0.001275385 MLANA ENSG00000120215 127.3562021 1.44905684 0.000122932 0.001282047 ALDH5A1 ENSG00000112294 376.8941597 -1.090058194 0.000123206 0.001284017 CELSR1 ENSG00000075275 703.1101736 -0.626946896 0.000124849 0.001298971 ZNF572 ENSG00000180938 87.10385219 -0.727621098 0.000124995 0.001299844 EIF3M ENSG00000149100 10584.26201 0.232375121 0.000125431 0.001303446 B3GALT2 ENSG00000162630 40.92959792 -1.531862737 0.000126215 0.001310466 ACTL6A ENSG00000136518 1776.097037 -0.415140167 0.000126243 0.001310466 CLEC5A ENSG00000258227 1098.317639 0.978961565 0.000126936 0.001316719 DGKA ENSG00000065357 15859.27644 -0.482015788 0.000128946 0.001335646 TMEM106C ENSG00000134291 877.1442024 -0.487926516 0.000129608 0.00134106 SDHB ENSG00000117118 5209.827708 0.332371643 0.000129801 0.001341613 CENPT ENSG00000102901 3660.778604 -0.39650683 0.000129887 0.001342027 FUCA2 ENSG00000001036 3472.531839 0.556044372 0.000129961 0.001342308 CNR2 ENSG00000188822 1264.657074 -0.624348857 0.000130923 0.001351276 SCYL3 ENSG00000000457 1973.328186 -0.401331912 0.000131139 0.00135254 KIAA1161 ENSG00000164976 51.23311525 -0.935902761 0.000131097 0.00135254 RAPH1 ENSG00000173166 99.23657387 0.973338484 0.000132364 0.001363231 C17orf67 ENSG00000214226 895.9845954 -0.470365002 0.000133533 0.0013738 AMIGO2 ENSG00000139211 1314.787713 -0.572947877 0.000135138 0.001388828 DNAJB2 ENSG00000135924 2889.764996 -0.435553677 0.000136185 0.001397107 SPRN ENSG00000203772 261.6236076 -0.690663021 0.00013681 0.00140252 GPATCH11 ENSG00000152133 1938.861848 -0.464400607 0.000137836 0.001410533 ZNF711 ENSG00000147180 237.7004116 -0.622108009 0.000138233 0.001414098 IDH3G ENSG00000067829 4997.861815 0.291527616 0.000140152 0.001432711 ATIC ENSG00000138363 3128.145242 -0.358912171 0.000140325 0.001433977

RPH3A ENSG00000089169 840.4886996 1.213254568 0.000140947 0.001439817 APBB1 ENSG00000166313 3272.103166 -0.696871094 0.000141009 0.001439945 IFT46 ENSG00000118096 491.0126087 -0.428098234 0.000141287 0.001442165 SEC11A ENSG00000140612 7722.997191 0.380631102 0.000141326 0.001442165 TRUB2 ENSG00000167112 1144.88829 -0.454498164 0.000141408 0.001442491 NINJ2 ENSG00000171840 749.0501402 0.575290568 0.000141868 0.001446673 HGSNAT ENSG00000165102 6033.159653 0.565043084 0.000142123 0.001448764 SPC25 ENSG00000152253 63.98112513 1.347621723 0.000142305 0.001449206 NTNG1 ENSG00000162631 10.31895101 -1.621370656 0.000142317 0.001449206 RAD1 ENSG00000113456 1329.70144 -0.372015283 0.000142301 0.001449206 AIRE ENSG00000160224 43.65714353 -1.464740434 0.000142674 0.001451568 ITLN1 ENSG00000179914 81.16583014 1.172583789 0.000142649 0.001451568 MRPS31 ENSG00000102738 1531.782311 -0.569574054 0.000142894 0.001452674 DCLRE1A ENSG00000198924 694.3323348 -0.717997713 0.000142909 0.001452674 TEX10 ENSG00000136891 2494.874435 -0.323654874 0.000142977 0.001452856 MANEAL ENSG00000185090 106.9034521 -0.808714187 0.000143517 0.001457319 KIAA0930 ENSG00000100364 11495.72374 0.479193818 0.000146414 0.001481523 TCTN1 ENSG00000204852 701.3076534 -0.461249011 0.000146946 0.001484089 NCAPG ENSG00000109805 264.6936393 1.046208402 0.000146846 0.001484089 TBL1XR1 ENSG00000177565 7267.88958 0.300041184 0.000147096 0.001484412 KPNA2 ENSG00000182481 1818.108327 0.528121751 0.000147961 0.00149186 ZNF219 ENSG00000165804 386.4801695 0.730804264 0.000148198 0.001492781 FCGR1A ENSG00000150337 2267.043346 0.790125293 0.000148721 0.001497003 GNAQ ENSG00000156052 12980.71546 0.751031194 0.000149264 0.001501422 MRS2 ENSG00000124532 2625.457532 -0.421879604 0.000150155 0.001509858 TBC1D17 ENSG00000104946 3636.91754 -0.412349579 0.000150245 0.001510237 ZNF853 ENSG00000236609 397.7857653 -0.708859862 0.000151199 0.001517713 C14orf1 ENSG00000133935 850.9701831 -0.79131671 0.000151442 0.001519105 MORC2 ENSG00000133422 3183.599345 -0.320660507 0.000151946 0.001522565 ZNF322 ENSG00000181315 624.1418351 -0.789301082 0.000153167 0.001532676 MPC1 ENSG00000060762 3286.782641 0.3915092 0.000153244 0.001532918 WDR35 ENSG00000118965 866.6938409 -0.371581296 0.000153501 0.001534954 IL18 ENSG00000150782 1125.477497 0.851477919 0.000154751 0.001545847 PSMB5 ENSG00000100804 1373.682853 -0.334016391 0.000155708 0.001554338 DGAT2 ENSG00000062282 2796.571301 1.116657195 0.000157282 0.001567277 MT-ND2 ENSG00000198763 262944.0079 0.422610808 0.000157956 0.001572429 SLC12A6 ENSG00000140199 14263.56263 0.510294232 0.000158184 0.001574158 ZNF543 ENSG00000178229 206.9639842 -0.773338269 0.000158387 0.001575636 VSIG1 ENSG00000101842 678.3902549 -0.868713455 0.000158806 0.001579256 TAPT1 ENSG00000169762 2685.114956 0.29718231 0.000159809 0.001588144 PGAM4 ENSG00000226784 216.8581416 0.600641662 0.000159969 0.00158864 UQCC2 ENSG00000137288 1535.935676 -0.438868591 0.000159964 0.00158864 ITGA7 ENSG00000135424 235.8194981 0.851231402 0.000160109 0.001589481 C1orf216 ENSG00000142686 1059.531102 -0.454701551 0.000160833 0.001595572 MPP7 ENSG00000150054 4821.646983 0.656395161 0.000161717 0.001602689 SLC1A7 ENSG00000162383 445.3547482 -1.314652914 0.000162349 0.001607297

BLVRB ENSG00000090013 3519.598136 0.808746728 0.000163499 0.001617018 ZNF823 ENSG00000197933 188.9242711 -0.726844913 0.000163713 0.001618514 EPHA1 ENSG00000146904 956.1924592 -0.643238119 0.00016414 0.001621692 CCDC149 ENSG00000181982 1800.630669 0.624875845 0.000164453 0.001624128 ORAOV1 ENSG00000149716 2108.893151 -0.426433677 0.000166208 0.001640443 ZSCAN32 ENSG00000140987 1052.683527 -0.652335301 0.000166468 0.001642446 ACTB ENSG00000075624 295540.5651 0.450382266 0.000166989 0.00164703 TIMM23 ENSG00000265354 2061.714509 0.301185462 0.000167049 0.001647062 BCL11B ENSG00000127152 9184.101335 -0.607996331 0.000167482 0.001649476 CDKN1C ENSG00000129757 503.1502527 -0.954070654 0.000167521 0.001649476 GTF2IRD2B ENSG00000174428 2104.753813 -0.365901585 0.000167582 0.001649476 TAP1 ENSG00000168394 15792.43356 -0.475410046 0.000168347 0.001655584 TMEM127 ENSG00000135956 11105.16904 0.608773528 0.000168442 0.001655584 SPRY3 ENSG00000168939 462.3590385 0.618333737 0.000169672 0.001663267 AGFG1 ENSG00000173744 10319.97113 1.030554296 0.000169766 0.001663374 MED4 ENSG00000136146 3705.410412 0.2458882 0.000169842 0.001663374 ICE2 ENSG00000128915 3299.867019 -0.372666992 0.000169855 0.001663374 MYBPC3 ENSG00000134571 765.3028378 0.77273303 0.000171132 0.001674739 NDUFB10 ENSG00000140990 2484.281906 0.361098188 0.00017139 0.001676698 SLC1A4 ENSG00000115902 2049.97835 0.860399528 0.000171471 0.001676921 SEMA4G ENSG00000095539 170.1480191 -0.617175338 0.000171566 0.001677283 FOSL1 ENSG00000175592 417.4161903 1.038887777 0.000172704 0.001686699 SELL ENSG00000188404 65475.65897 0.538910179 0.000172793 0.001686992 PTPN12 ENSG00000127947 10958.19246 0.490179084 0.000173304 0.001690839 SKAP2 ENSG00000005020 9521.603481 0.578510703 0.00017389 0.001695411 COX7B ENSG00000131174 3433.339619 0.41248802 0.000174425 0.001700057 KREMEN1 ENSG00000183762 676.9519527 1.252377834 0.00017483 0.001703424 NOL10 ENSG00000115761 1768.22675 0.296039843 0.00017497 0.001703733 ITGA3 ENSG00000005884 323.65869 -0.727460417 0.000175324 0.001705944 MELTF ENSG00000163975 171.0692255 1.064150222 0.000175273 0.001705944 DNM2 ENSG00000079805 17415.42275 0.273552751 0.000177454 0.001724345 TXNDC2 ENSG00000168454 20.20824197 1.457303437 0.000177836 0.001727475 NIPSNAP3B ENSG00000165028 143.7577334 -0.59946202 0.000178299 0.001730863 ZNF829 ENSG00000185869 323.2345071 -0.754799627 0.000179639 0.001742387 PPP2R2A ENSG00000221914 6085.481977 0.294605769 0.00017987 0.001743131 KCNG1 ENSG00000026559 142.0080329 -1.316719971 0.000179965 0.001743463 GALNT12 ENSG00000119514 809.475604 -0.625476336 0.00018122 0.001754365 BAG1 ENSG00000107262 3582.255941 0.365109939 0.000181874 0.001757834 PRPF39 ENSG00000185246 4763.866279 -0.283955994 0.000182539 0.001763316 WBP2NL ENSG00000183066 95.09182332 -0.456652606 0.000182564 0.001763316 SLC25A37 ENSG00000147454 11110.88854 1.144896744 0.000182683 0.001763882 GDF15 ENSG00000130513 23.28105241 1.162732908 0.000183447 0.001770666 TNS3 ENSG00000136205 3780.970391 0.602452375 0.00018453 0.001778422 ETV3 ENSG00000117036 3999.829521 0.54901655 0.000185236 0.001784353 UBR3 ENSG00000144357 2748.217643 0.404434793 0.000186494 0.001794681 CYB5A ENSG00000166347 847.5531132 -0.636613848 0.000188386 0.001811674

WDR3 ENSG00000065183 1526.604674 -0.363841732 0.000189196 0.001816649 SBK1 ENSG00000188322 2439.33743 -0.849936781 0.000189904 0.001821876 RBMS1 ENSG00000153250 11050.18893 0.321006338 0.000190606 0.001826341 EIF2B5 ENSG00000145191 5936.988231 -0.235418758 0.000190693 0.001826569 ADGRE2 ENSG00000127507 13401.45007 0.56468715 0.000191189 0.001830106 KIAA0825 ENSG00000185261 224.081381 0.748471769 0.000191902 0.001836319 ZUFSP ENSG00000153975 1265.996066 0.385797927 0.00019206 0.001837226 RAB6B ENSG00000154917 321.726838 -0.678499296 0.00019229 0.00183882 ENPP1 ENSG00000197594 30.09127967 -1.545750799 0.000193556 0.001849084 DPH7 ENSG00000148399 2082.157692 -0.383374355 0.000193801 0.001850621 USP48 ENSG00000090686 11551.25036 0.3065998 0.00019456 0.001856224 FLAD1 ENSG00000160688 2099.956133 -0.405612503 0.000195698 0.001864616 MEN1 ENSG00000133895 2474.223508 -0.420261739 0.000196474 0.001869544 RARA ENSG00000131759 10158.17005 0.518740729 0.000196871 0.001872706 COG2 ENSG00000135775 2881.786907 -0.272228846 0.000197072 0.001873999 NLRP7 ENSG00000167634 75.70451073 -0.842262317 0.000199147 0.001889997 DEPDC7 ENSG00000121690 75.30821499 -0.934081432 0.000199429 0.001892056 INPPL1 ENSG00000165458 13147.55636 0.294610548 0.000200834 0.001904133 MTFMT ENSG00000103707 626.4340693 -0.500271118 0.000200994 0.001905021 ILKAP ENSG00000132323 5489.451697 0.389335248 0.000201339 0.001907047 SLC45A3 ENSG00000158715 1101.690919 -0.970932713 0.000201696 0.001909173 ZNF831 ENSG00000124203 5820.02768 -0.550391191 0.00020264 0.001915867 SRGAP2D ENSG00000270872 1745.049563 0.799121219 0.000203149 0.001919154 RAD23B ENSG00000119318 9420.689824 0.469137254 0.000203433 0.001919949 WNT16 ENSG00000002745 130.9309681 -1.093654809 0.000204217 0.001926091 GZMA ENSG00000145649 8292.057827 -0.880666603 0.000204822 0.001931167 SAT2 ENSG00000141504 1947.455192 0.364854336 0.000206291 0.001943747 KBTBD11 ENSG00000176595 2277.783861 1.084797696 0.000206381 0.001943962 TRAF7 ENSG00000131653 4292.822797 0.339596044 0.000207002 0.001948219 ERH ENSG00000100632 5550.196673 0.252957497 0.000207201 0.001949149 CYP4F22 ENSG00000171954 150.442946 -1.084538795 0.000207316 0.001949449 CX3CR1 ENSG00000168329 10712.3781 -1.215639364 0.000208332 0.001956601 GLIPR1 ENSG00000139278 11239.79884 0.783045842 0.000210222 0.001973068 ZMYM1 ENSG00000197056 1548.572247 -0.582523871 0.00021047 0.001974109 LTB ENSG00000227507 8030.500066 -0.80776729 0.000210414 0.001974109 IMPDH1 ENSG00000106348 10665.42816 0.469407744 0.000210915 0.001977649 SPTLC2 ENSG00000100596 11369.95422 0.629912705 0.000211455 0.001980775 SKAP1 ENSG00000141293 4086.431251 -0.630682301 0.000212228 0.001987377 ADAM10 ENSG00000137845 14800.07936 0.429280041 0.000212297 0.001987381 CD99L2 ENSG00000102181 2770.28252 0.394132798 0.000213769 0.002000511 SNRPB2 ENSG00000125870 3864.713255 0.277982424 0.000214549 0.00200716 RAB1A ENSG00000138069 6601.920321 0.66976589 0.000214674 0.002007654 PRKAG2 ENSG00000106617 5765.633694 0.461539005 0.000214928 0.002008752 CIR1 ENSG00000138433 5171.19045 0.516269818 0.000215262 0.002011227 ZC3H12B ENSG00000102053 246.9323717 -0.844665862 0.00021596 0.002015137 CLINT1 ENSG00000113282 8338.944769 0.311985546 0.000216831 0.002022612

FLOT1 ENSG00000137312 10495.69611 0.420818293 0.000217435 0.002027592 COL13A1 ENSG00000197467 135.7917746 -1.410262809 0.000218501 0.002036221 UBA7 ENSG00000182179 11576.22374 -0.338292729 0.000219113 0.002040601 GPATCH1 ENSG00000076650 1350.44512 -0.283381823 0.00021955 0.002043357 KIAA1033 ENSG00000136051 12773.33067 0.485272739 0.000221499 0.002060828 DPP4 ENSG00000197635 2390.654209 -0.644064316 0.000221984 0.002063577 CEP55 ENSG00000138180 186.9495967 1.031221375 0.000222008 0.002063577 NARFL ENSG00000103245 1897.834477 -0.376155273 0.000222411 0.002066655 C12orf73 ENSG00000204954 217.5109826 -0.430328742 0.000224175 0.002080724 PTBP2 ENSG00000117569 2480.327994 0.896373329 0.000224575 0.002082741 GPM6B ENSG00000046653 238.5613799 -0.762577309 0.000224692 0.002083157 HDHD3 ENSG00000119431 681.4854236 -0.695057866 0.000228591 0.002112533 GSTO1 ENSG00000148834 5256.333778 0.492033323 0.00023191 0.00213978 COG4 ENSG00000103051 3659.300107 -0.41498621 0.000232529 0.002144121 ZFYVE21 ENSG00000100711 974.9576072 -0.402197649 0.000232704 0.002145046 RTN3 ENSG00000133318 14638.74844 0.735807332 0.000232895 0.00214613 FAM171A1 ENSG00000148468 256.5160263 -1.094025604 0.000234086 0.002155725 ANKRD13B ENSG00000198720 155.5537495 -0.630566912 0.000236347 0.002171015 ZNF330 ENSG00000109445 3829.167733 0.424215211 0.000238672 0.002190282 AEBP1 ENSG00000106624 747.2507537 -0.640530647 0.000239102 0.002192623 TBC1D15 ENSG00000121749 4091.452014 0.567088827 0.000240192 0.002198738 ALDH1A2 ENSG00000128918 110.8806351 1.392934202 0.000240279 0.002198738 TBC1D12 ENSG00000108239 841.8452164 0.727857157 0.000241217 0.002206625 RP11-563J2.3 ENSG00000212743 220.5727737 0.914763586 0.000241775 0.002210418 EIF5A2 ENSG00000163577 515.2996862 -0.539441862 0.000241785 0.002210418 KCTD12 ENSG00000178695 20715.84744 0.679300913 0.00024207 0.002212325 NANS ENSG00000095380 2270.474585 0.458806056 0.000242642 0.002216852 DCP1B ENSG00000151065 1398.957939 -0.470261622 0.000242746 0.002217099 OTUD7B ENSG00000264522 662.1677399 -0.505473358 0.000244484 0.002230155 LBR ENSG00000143815 8243.683858 0.590739765 0.000244626 0.002230746 MARK3 ENSG00000075413 9843.520877 0.20474755 0.000244728 0.002230968 GLIPR2 ENSG00000122694 17155.12187 0.553948817 0.00024715 0.002248512 PSMD3 ENSG00000108344 5591.899381 0.253114096 0.000247429 0.00224991 FBXL16 ENSG00000127585 537.6172158 -0.788400604 0.000247666 0.002251363 PHC1 ENSG00000111752 3934.55375 -0.608793277 0.000247754 0.002251448 CDK1 ENSG00000170312 254.4573277 1.180976944 0.000249566 0.002265781 METTL18 ENSG00000171806 454.6650742 -0.551752949 0.000249973 0.002268049 ZNF260 ENSG00000254004 808.4275236 -0.716204169 0.000250663 0.00227288 CCDC121 ENSG00000176714 64.04261209 -1.088873236 0.00025121 0.002275778 PER2 ENSG00000132326 1316.330671 0.46514891 0.000251702 0.00227801 LAMB3 ENSG00000196878 100.1788626 1.029403889 0.000251982 0.002279831 THUMPD2 ENSG00000138050 1525.454992 0.461749262 0.000252291 0.002281198 CDCA5 ENSG00000146670 250.1295863 1.15839133 0.000252216 0.002281198 ZNF569 ENSG00000196437 593.4334359 -0.416575347 0.000253087 0.002286964 CCNA2 ENSG00000145386 539.9136663 0.867335263 0.000255698 0.002309116 GSTZ1 ENSG00000100577 530.074695 0.555606483 0.000256327 0.002314068

PLEKHA1 ENSG00000107679 4275.866566 -0.527151608 0.000256749 0.002316438 ZCCHC2 ENSG00000141664 4818.794788 0.59941775 0.000256707 0.002316438 NOD1 ENSG00000106100 2215.089889 -0.33651477 0.000257261 0.002319607 TRIB1 ENSG00000173334 6544.73528 0.836853595 0.000259026 0.002333337 NEK2 ENSG00000117650 81.49321611 1.180960115 0.000262371 0.002357587 ALDH1B1 ENSG00000137124 277.4518104 -0.622631264 0.000262543 0.002358399 DPY19L3 ENSG00000178904 1742.826064 0.790751043 0.000264211 0.002371171 C17orf75 ENSG00000108666 893.9540504 -0.348856041 0.000266691 0.002389714 AGPS ENSG00000018510 4431.73598 0.438391491 0.000266919 0.002391014 DDR1 ENSG00000204580 431.2544358 -0.649462177 0.000268463 0.002402615 CXCL2 ENSG00000081041 162.6328951 1.325709241 0.000268799 0.002404875 HK3 ENSG00000160883 17759.67848 0.5654969 0.000270803 0.002417558 XCL2 ENSG00000143185 448.2633181 -0.870371704 0.000271889 0.002425446 RP11-463J10.2 ENSG00000258928 771.8010703 0.977040376 0.000271938 0.002425446 SYT2 ENSG00000143858 37.42577596 -0.93540918 0.000272077 0.002425936 POMT1 ENSG00000130714 2992.914433 -0.293872187 0.000272805 0.002431679 UBASH3A ENSG00000160185 2872.212862 -0.812179523 0.000273791 0.002439712 EPC2 ENSG00000135999 5532.25614 0.358537868 0.000275022 0.00244911 FCGR1CP ENSG00000265531 500.2691934 1.050458399 0.000275185 0.00244911 CUL2 ENSG00000108094 3372.085095 0.334653344 0.000276106 0.002455042 HCLS1 ENSG00000180353 57173.92729 0.310092333 0.000276591 0.002456332 ICMT ENSG00000116237 1784.026608 -0.565297485 0.000276713 0.002456657 TMEM64 ENSG00000180694 875.6371718 -0.541027277 0.000276837 0.002456995 GPR89B ENSG00000188092 1392.110124 -0.501751135 0.000277845 0.002464434 KDM6A ENSG00000147050 5856.829661 0.556487368 0.000278273 0.002466829 CCL5 ENSG00000271503 22332.86166 -0.857691115 0.000279387 0.002475583 SYNJ1 ENSG00000159082 3541.114033 0.554651894 0.000279445 0.002475583 DNAJC19 ENSG00000205981 984.3549421 -0.307707294 0.000279641 0.002476562 CA11 ENSG00000063180 545.2487126 -0.930061269 0.000280452 0.002481459 EXPH5 ENSG00000110723 133.8372364 -0.78936084 0.000281306 0.002488261 RNASEL ENSG00000135828 2008.301967 -0.574372492 0.000283907 0.002508195 MTM1 ENSG00000171100 1723.714725 0.508209482 0.000285216 0.002517445 BNIP1 ENSG00000113734 826.6728456 0.423610174 0.000285569 0.002519797 ZNF696 ENSG00000185730 139.8073775 -1.091886407 0.000285961 0.002522478 HIBCH ENSG00000198130 656.3537358 -0.406529427 0.000288101 0.002538258 PARS2 ENSG00000162396 99.56776146 -1.173504677 0.000288643 0.002541482 TNKS ENSG00000173273 2160.015499 0.60150457 0.000289036 0.002544173 CDKN2D ENSG00000129355 6715.7531 0.583885179 0.000289884 0.002550078 SHROOM1 ENSG00000164403 825.3288487 0.883855073 0.000291134 0.002558362 KLHL24 ENSG00000114796 3939.887081 0.951675503 0.000293699 0.002577357 DYRK2 ENSG00000127334 1557.358071 -0.902477039 0.000297423 0.002603715 PPIAL4E ENSG00000271567 7.064474386 -1.395164744 0.000298118 0.002608218 PPP1R13B ENSG00000088808 1130.069672 -0.465853872 0.000299075 0.002615799 INO80E ENSG00000169592 3058.946253 -0.37395057 0.000299283 0.002616828 EXOC6 ENSG00000138190 1947.380969 0.445204829 0.000300663 0.002625715 CNOT2 ENSG00000111596 5050.585425 0.431473117 0.000301182 0.002629448

TMCC3 ENSG00000057704 2473.560896 0.850148277 0.000302197 0.002635125 DTX4 ENSG00000110042 6420.944759 0.688948384 0.000302181 0.002635125 CELSR2 ENSG00000143126 667.8301834 -0.506450387 0.000302118 0.002635125 CYB5R3 ENSG00000100243 5685.062336 0.283540377 0.000302423 0.0026363 MAN1C1 ENSG00000117643 1392.242678 -0.531535926 0.000302661 0.002637012 RPGR ENSG00000156313 1754.391942 0.439301672 0.000302687 0.002637012 LTK ENSG00000062524 1034.635022 -0.923924599 0.000303226 0.002640114 NCAPD3 ENSG00000151503 2375.618074 -0.408166683 0.000303217 0.002640114 SPAG16 ENSG00000144451 250.2352584 -0.699714278 0.000304223 0.002648 NAALAD2 ENSG00000077616 207.3612817 -0.659237771 0.000304799 0.002652209 SHKBP1 ENSG00000160410 11823.41924 0.42531096 0.000305259 0.00265541 CXCR6 ENSG00000172215 244.2962904 -0.983292655 0.000306299 0.002661251 TRABD2A ENSG00000186854 5516.570861 -0.642904303 0.000308684 0.00267795 RPGRIP1L ENSG00000103494 180.5342099 -0.608907901 0.000309915 0.002687818 PPAT ENSG00000128059 665.8735391 -0.47562988 0.000312784 0.002710265 PRMT2 ENSG00000160310 10626.00115 -0.349545722 0.000313079 0.002712008 CCDC58 ENSG00000160124 563.3758486 -0.487895531 0.000313479 0.002713845 KNL1 ENSG00000137812 323.5794985 0.835368817 0.00031456 0.002720759 DLGAP5 ENSG00000126787 203.0988254 1.117918 0.000315232 0.002724935 RFLNB ENSG00000183688 10068.21403 0.557390401 0.000316417 0.002734361 ANKRD50 ENSG00000151458 1773.389445 0.696105008 0.000316743 0.002735544 GEMIN2 ENSG00000092208 324.2967821 -0.468581101 0.000316966 0.002736647 FAM212A ENSG00000185614 61.99753736 -0.970362393 0.000317709 0.002742247 TRPC1 ENSG00000144935 257.9263849 -0.674040644 0.000317879 0.002742897 S100A10 ENSG00000197747 19460.60361 0.599577561 0.00032069 0.002763849 USP38 ENSG00000170185 4108.265971 0.327853536 0.000322941 0.002780756 PNO1 ENSG00000115946 1125.570463 0.449573959 0.000324428 0.002792727 MRPS22 ENSG00000175110 2536.261775 0.268042312 0.000325657 0.002801641 NAALADL1 ENSG00000168060 508.437999 -0.471391445 0.000326884 0.002809684 LY86 ENSG00000112799 2507.592087 0.55005365 0.000327054 0.002810306 TMX1 ENSG00000139921 4142.225257 0.497404444 0.00033151 0.002845217 TSPAN5 ENSG00000168785 741.3324589 -0.64430356 0.000335198 0.002872596 ENO1 ENSG00000074800 48471.67966 0.403164935 0.000335806 0.002876953 ADGRL1 ENSG00000072071 2149.544714 -0.548371615 0.000336753 0.002884216 EXD3 ENSG00000187609 1007.143242 -0.395392607 0.000339376 0.002903236 RP11-863K10.7 ENSG00000183154 75.83342287 0.908779888 0.000340461 0.002910384 ARPP19 ENSG00000128989 10473.22871 0.343069015 0.000343023 0.002925773 UBXN4 ENSG00000144224 16073.91459 0.321851662 0.000343387 0.002928017 RXFP4 ENSG00000173080 69.00044138 -0.796754946 0.000344592 0.002936553 KLF14 ENSG00000266265 10.5232985 1.588778284 0.000346057 0.002945562 SELENOM ENSG00000198832 278.0777015 -0.562257537 0.000347013 0.002952627 NAP1L2 ENSG00000186462 246.8200379 -0.875981103 0.000349348 0.002970071 RPP25L ENSG00000164967 484.950575 -0.593918559 0.000349793 0.002972983 OPTN ENSG00000123240 6648.970746 -0.572224581 0.000350618 0.002978242 C4orf46 ENSG00000205208 859.9203187 0.511105047 0.000350856 0.002979389 HSPA13 ENSG00000155304 2184.936415 0.601734988 0.000350961 0.002979407

SH2B1 ENSG00000178188 5133.87442 -0.305877956 0.000351326 0.002981626 DTX3 ENSG00000178498 1126.525651 -0.610043016 0.000351606 0.002983127 PPIP5K1 ENSG00000168781 1325.526809 -0.317194268 0.000351901 0.002984753 COQ3 ENSG00000132423 211.1021772 -0.542226017 0.000353145 0.002994422 WDR54 ENSG00000005448 571.6127632 -0.595570199 0.000354034 0.002999319 PRRT4 ENSG00000224940 267.2594759 1.339988846 0.000354458 0.003002032 CBR3 ENSG00000159231 103.8655826 -0.928658226 0.000358445 0.003026046 SPIN3 ENSG00000204271 1624.642488 -0.43489603 0.000358427 0.003026046 IFITM3 ENSG00000142089 14362.86941 0.762866592 0.000359128 0.003030041 IKBKAP ENSG00000070061 5767.25914 -0.327425318 0.000359072 0.003030041 B3GNT7 ENSG00000156966 638.4212552 1.389573099 0.000360763 0.003041172 TESK1 ENSG00000107140 2494.041701 -0.31968336 0.000361672 0.003047944 TNFSF15 ENSG00000181634 29.59563231 -1.322307214 0.000361854 0.003048585 RASGRF2 ENSG00000113319 1909.825112 -0.578337323 0.000365511 0.003074916 VPREB3 ENSG00000128218 314.5163364 -0.928273356 0.000365494 0.003074916 CARD8 ENSG00000105483 14235.98205 -0.43876847 0.000367741 0.00309097 TOP2A ENSG00000131747 893.8177201 0.973590796 0.000369286 0.003101248 RARRES3 ENSG00000133321 4975.598198 -0.61006864 0.000369519 0.003102305 SIPA1L1 ENSG00000197555 6440.733412 0.486940652 0.000370859 0.003112654 C14orf132 ENSG00000227051 157.9563299 -0.878463783 0.000371566 0.003117678 RASGRP2 ENSG00000068831 28227.65252 -0.417832361 0.000373071 0.003128487 KCTD11 ENSG00000213859 598.7333419 -0.722084076 0.000374044 0.003134833 CCDC107 ENSG00000159884 1019.874446 -0.400790785 0.000374561 0.003138251 DEPDC1 ENSG00000024526 47.22188658 1.329272172 0.000375308 0.0031436 FAM76B ENSG00000077458 4939.860013 0.356695112 0.000376617 0.003152734 HNRNPAB ENSG00000197451 6463.034655 0.285832459 0.000377486 0.003159092 MPO ENSG00000005381 5221.07041 1.467394956 0.000377861 0.00316132 CLPB ENSG00000162129 1400.821955 0.598244239 0.000377977 0.00316137 ACD ENSG00000102977 1091.714977 -0.501630416 0.000379465 0.003170142 RAD9A ENSG00000172613 1897.11807 -0.447473546 0.000381173 0.003181958 ZFR ENSG00000056097 8280.295377 0.307627033 0.000381209 0.003181958 AAED1 ENSG00000158122 1187.262406 0.341718344 0.000381981 0.003187474 CNIH2 ENSG00000174871 122.3156889 0.705215636 0.000383454 0.003197925 DNAJC5B ENSG00000147570 35.41138168 1.089407032 0.000384877 0.003207934 LINC01588 ENSG00000214900 755.9589029 -0.589363521 0.00038569 0.003212862 EMP2 ENSG00000213853 14.72243491 1.674522487 0.000387042 0.003220406 DYNC1LI2 ENSG00000135720 9006.268364 0.392529071 0.000391021 0.00324927 SCUBE1 ENSG00000159307 109.8794596 1.169440251 0.000394137 0.003270961 TGFB3 ENSG00000119699 439.2834273 -0.547608343 0.000394609 0.003273937 TMEM59 ENSG00000116209 10507.81175 0.239724485 0.000395123 0.003277265 PIK3R1 ENSG00000145675 18831.34471 0.72780683 0.000395244 0.003277326 ACSS3 ENSG00000111058 45.39495329 1.155928298 0.000396814 0.003287911 HSD17B8 ENSG00000204228 370.0814979 -0.650037012 0.000398378 0.003295747 SHFM1 ENSG00000127922 4317.441141 0.478026932 0.000399132 0.003301036 YWHAE ENSG00000108953 7615.636384 0.396717424 0.000399961 0.003306944 MMP9 ENSG00000100985 4354.400689 1.49022862 0.000400725 0.003310787

CTR9 ENSG00000198730 4791.446022 -0.398620355 0.000402872 0.003326256 COL9A3 ENSG00000092758 257.3034649 0.826169289 0.000403148 0.003327583 STX18 ENSG00000168818 2956.488227 0.260774433 0.000405609 0.003345027 PPA2 ENSG00000138777 2413.038076 0.269270458 0.000406118 0.003348268 GATM ENSG00000171766 89.06907278 -0.832709493 0.000406393 0.003349586 PRPF40B ENSG00000110844 385.2397819 -0.5194197 0.000406741 0.003351498 PCID2 ENSG00000126226 2657.613138 -0.454031937 0.000409975 0.003375256 AP000322.53 ENSG00000243627 18.19325193 1.061569809 0.000411632 0.003387934 SLC35A2 ENSG00000102100 502.3137237 0.614488557 0.000412533 0.003392445 IDE ENSG00000119912 2287.418678 0.332558563 0.000412727 0.003393076 ZNF610 ENSG00000167554 62.75222576 -0.975376053 0.000413252 0.003396424 CD86 ENSG00000114013 7042.007168 0.638095038 0.000416586 0.003420908 METTL3 ENSG00000165819 5632.212822 -0.214961642 0.000417673 0.003428856 SLC25A22 ENSG00000177542 1390.492222 -0.451986199 0.000418912 0.003437081 SPG21 ENSG00000090487 7850.23153 0.367692292 0.000421634 0.003455483 C7orf73 ENSG00000243317 4923.907456 0.38512293 0.0004223 0.003459958 RP3-461P17.10 ENSG00000269549 134.9596012 -0.714502935 0.000423014 0.003464829 MBIP ENSG00000151332 1404.282709 0.359691518 0.000424409 0.003473305 CHMP2B ENSG00000083937 3496.242277 0.608034614 0.000424907 0.003475296 MED13 ENSG00000108510 8688.661292 0.310958481 0.000425014 0.003475296 GNB2 ENSG00000172354 14211.0653 0.434892217 0.000425918 0.003481454 AP2A1 ENSG00000196961 9805.40698 0.315748561 0.000426121 0.003481454 B4GALNT3 ENSG00000139044 176.5865744 -1.056611956 0.000426887 0.00348667 TERF1 ENSG00000147601 1935.64727 0.43471113 0.000427252 0.003488664 CNEP1R1 ENSG00000205423 1987.44039 0.654156961 0.00042753 0.003489948 IRAK2 ENSG00000134070 643.006045 -0.617660887 0.000429428 0.003500492 SLC22A18AS ENSG00000254827 52.67583131 0.920325851 0.000429595 0.003500865 SUCNR1 ENSG00000198829 174.5042116 1.316509392 0.000430796 0.003509662 BUB1 ENSG00000169679 425.0045312 1.084079966 0.000431369 0.003513339 UBXN2B ENSG00000215114 6668.28981 0.488670552 0.000435352 0.003542782 ARAF ENSG00000078061 8730.436398 0.296439455 0.000436185 0.003547564 GCN1 ENSG00000089154 8997.342409 -0.322112283 0.000436076 0.003547564 EIF3H ENSG00000147677 21694.66116 0.252209545 0.000438496 0.003563349 AASDH ENSG00000157426 1112.81887 -0.356171281 0.00043959 0.003571235 DHX29 ENSG00000067248 3178.088136 0.293126875 0.000442164 0.003588108 LAYN ENSG00000204381 66.15379043 1.113302534 0.000444966 0.003606799 PGA3 ENSG00000229859 118.3935557 1.304677583 0.000445691 0.003611656 ENO3 ENSG00000108515 1246.387807 -0.543466506 0.000445881 0.003612187 NUDT16 ENSG00000198585 2481.247218 0.964634881 0.000446295 0.003614527 NR1H2 ENSG00000131408 4776.547023 0.449718449 0.000447168 0.003619567 ZNF426 ENSG00000130818 828.1707702 -0.571462577 0.000447474 0.003621032 DOK3 ENSG00000146094 9538.011983 0.727138168 0.000449547 0.003635768 BASP1 ENSG00000176788 5300.034167 0.835479901 0.000455931 0.003680671 PREPL ENSG00000138078 2215.526306 -0.597496154 0.000455991 0.003680671 CCL20 ENSG00000115009 35.46576693 1.466122897 0.00045723 0.003689638 CIDEB ENSG00000136305 2615.250417 0.438335363 0.000457371 0.003689749

TMEM132C ENSG00000181234 12.82935487 -1.564909616 0.000459877 0.003707894 MRPL50 ENSG00000136897 1027.691531 -0.535425321 0.000462607 0.003725849 TIMP4 ENSG00000157150 9.401265788 1.638968477 0.000462637 0.003725849 USP43 ENSG00000154914 88.35268133 -0.934199079 0.000464506 0.003737913 SACS ENSG00000151835 2549.612308 -0.650008029 0.000465967 0.003746539 XRCC4 ENSG00000152422 947.0371057 0.464895274 0.000465882 0.003746539 SUSD6 ENSG00000100647 14164.23346 0.387923361 0.00046715 0.00375501 PKDCC ENSG00000162878 7.763499026 -1.604715526 0.000467569 0.003757326 AGMAT ENSG00000116771 275.7221037 -0.694404328 0.000467797 0.00375812 HGD ENSG00000113924 131.4980132 -0.786086116 0.000469439 0.003767485 TSHZ1 ENSG00000179981 3282.904927 -0.521676026 0.000472076 0.003785123 DHRS13 ENSG00000167536 766.086854 -0.601891114 0.000473651 0.003794593 ZBTB21 ENSG00000173276 1741.374243 0.747298936 0.000474801 0.003800406 ACP6 ENSG00000162836 850.3287597 -0.426055772 0.000474755 0.003800406 ATP8B4 ENSG00000104043 1909.983846 0.768224739 0.000474903 0.003800406 LZTS2 ENSG00000107816 1567.244267 -0.389338671 0.000477688 0.003821636 DBF4 ENSG00000006634 966.5951768 0.50415527 0.000479465 0.003833635 PEX6 ENSG00000124587 1759.081049 -0.536002471 0.000480286 0.003837107 DBF4B ENSG00000161692 447.279738 -0.399749916 0.000482155 0.003846923 MED9 ENSG00000141026 728.3128359 0.440350937 0.000482313 0.003846923 TMEM132D ENSG00000151952 41.69835129 1.162372137 0.000484539 0.003861476 ATP6V1F ENSG00000128524 5220.680676 0.419792966 0.000485369 0.003867022 SMCR8 ENSG00000176994 10585.04066 0.470614855 0.000486096 0.003871016 TESC ENSG00000088992 1544.203877 0.552282738 0.00048757 0.003879211 UIMC1 ENSG00000087206 4759.598742 0.261517463 0.000487771 0.003879742 TMX4 ENSG00000125827 10137.75787 0.418674133 0.000488819 0.003884866 DNAI2 ENSG00000171595 75.3878032 -0.813776431 0.000490101 0.003892914 SPAG9 ENSG00000008294 6103.533417 0.494159562 0.000491347 0.003896381 ZNF266 ENSG00000174652 7146.394042 -0.594569221 0.000491154 0.003896381 BNIPL ENSG00000163141 91.55040433 -1.008394768 0.00049133 0.003896381 DVL2 ENSG00000004975 1940.614862 -0.33017709 0.000491282 0.003896381 NR2C2AP ENSG00000184162 431.6046474 -0.495695278 0.000494434 0.003917637 GAA ENSG00000171298 12386.85968 0.552906666 0.00049469 0.003918594 CDC25A ENSG00000164045 83.98554033 1.138658038 0.000497245 0.003936668 TMEM119 ENSG00000183160 157.530301 0.999329203 0.000498265 0.003943669 KIF14 ENSG00000118193 112.6945583 1.21285222 0.000499215 0.003949641 TAF5 ENSG00000148835 757.2142386 -0.288570205 0.000499395 0.003949641 PLCD3 ENSG00000161714 231.7511087 0.645466545 0.000501636 0.003965996 VIT ENSG00000205221 53.64535565 -1.329120097 0.000504216 0.003982038 ABHD15 ENSG00000168792 2375.129762 -0.385025191 0.000505179 0.003986373 RAP1B ENSG00000127314 28777.50804 0.301150012 0.000505411 0.003987114 RPUSD3 ENSG00000156990 1824.911587 -0.360408744 0.000506997 0.003997441 KCTD3 ENSG00000136636 667.7169612 0.671977103 0.000508936 0.004010543 S100P ENSG00000163993 1473.015284 1.395530563 0.000508818 0.004010543 TRAM1 ENSG00000067167 17581.22591 0.359251301 0.000512558 0.004034685 GPR171 ENSG00000174946 1177.222631 -0.617775669 0.000515398 0.004051522

CBX3 ENSG00000122565 5199.383212 0.302390006 0.000515905 0.004053302 BORCS6 ENSG00000196544 936.1938182 -0.528507989 0.000515901 0.004053302 ZMAT4 ENSG00000165061 89.35137815 -1.29149775 0.00051689 0.004058828 UBR2 ENSG00000024048 11998.96603 0.352508487 0.000518092 0.004067162 INHBB ENSG00000163083 27.14639625 1.597603925 0.000518449 0.004067754 FITM2 ENSG00000197296 665.1889916 -0.508871911 0.000518414 0.004067754 KLF10 ENSG00000155090 19893.32469 0.795197263 0.00051979 0.004077169 MCOLN3 ENSG00000055732 96.09037177 -0.945856537 0.000523914 0.004103947 ATP6V0B ENSG00000117410 7305.357137 0.494275325 0.000526635 0.004124139 LHFP ENSG00000183722 31.70755709 1.209609056 0.000531431 0.004158316 FHL1 ENSG00000022267 854.1122296 -0.61624583 0.000533623 0.004172083 TRUB1 ENSG00000165832 857.2736711 -0.413826853 0.000537354 0.004198979 BTBD1 ENSG00000064726 6620.956282 0.251584345 0.000538547 0.004207162 RAD23A ENSG00000179262 4898.362625 0.356609073 0.00053897 0.004209084 SCRG1 ENSG00000164106 38.87348982 1.176261593 0.00053923 0.004209084 ATXN1 ENSG00000124788 4807.696928 0.620194745 0.000540226 0.004210035 ZNF595 ENSG00000272602 971.095692 -0.660451149 0.00054011 0.004210035 COIL ENSG00000121058 1897.809558 0.280485143 0.000539971 0.004210035 CGGBP1 ENSG00000163320 12572.50812 -0.249538715 0.000540156 0.004210035 MAP4K1 ENSG00000104814 9431.897799 -0.40263812 0.000541434 0.004218307 GUCD1 ENSG00000138867 6998.060072 0.367544723 0.000541615 0.004218581 TRMU ENSG00000100416 2710.777185 -0.375544749 0.000542045 0.004220789 CD1E ENSG00000158488 64.76293525 -0.852343148 0.00054229 0.00422108 LIG1 ENSG00000105486 3147.79328 -0.471479174 0.000543801 0.004229901 WDR81 ENSG00000167716 5280.829464 -0.317910733 0.000544209 0.004230625 IL17RE ENSG00000163701 75.22183004 -0.776328228 0.0005443 0.004230625 FAM220A ENSG00000178397 793.5147652 -0.44026768 0.000546051 0.004242834 IL23R ENSG00000162594 20.07992569 -1.467572331 0.000547506 0.004250714 PCSK5 ENSG00000099139 1334.28644 0.553744647 0.000549558 0.004264351 SLC11A2 ENSG00000110911 3544.295401 0.337610043 0.000550826 0.004270747 SEC24A ENSG00000113615 2934.7693 0.473744925 0.000552857 0.004283051 PANX2 ENSG00000073150 427.1320387 1.017092827 0.000553099 0.004283773 FAM102B ENSG00000162636 4564.465529 0.44343998 0.000554277 0.004291749 CEP76 ENSG00000101624 339.2351092 -0.428770606 0.000555377 0.004299112 RGMA ENSG00000182175 47.03848296 1.232423169 0.000558297 0.004319404 CDCA2 ENSG00000184661 105.0708316 1.17177784 0.000558862 0.004322611 MCF2L ENSG00000126217 420.6082288 -0.606176641 0.000561569 0.004340066 CMTR2 ENSG00000180917 2037.917543 -0.633416562 0.000564222 0.004356547 UBXN11 ENSG00000158062 16597.25077 0.604220757 0.00056813 0.004381394 FGGY ENSG00000172456 241.6636358 0.336690374 0.000568702 0.004384637 PRC1 ENSG00000198901 748.1047731 0.770626647 0.000569018 0.004385836 IDI1 ENSG00000067064 3678.396729 0.572467391 0.000570371 0.004393986 L3MBTL2 ENSG00000100395 3019.212983 -0.322191748 0.00057184 0.004400808 DNAH3 ENSG00000158486 60.28425129 -0.876827136 0.000573559 0.004410313 IER3 ENSG00000137331 2642.642849 1.098487951 0.000575018 0.004419179 HDAC1 ENSG00000116478 9135.100016 -0.232078683 0.000575741 0.004422385

IL13RA1 ENSG00000131724 10012.33975 0.728057927 0.000580005 0.004448555 SNTA1 ENSG00000101400 316.3983175 -0.659434472 0.000580593 0.004450187 CENPBD1 ENSG00000177946 410.0952881 -0.554398285 0.000582536 0.004463331 ABCC3 ENSG00000108846 2070.485099 0.582848552 0.000585004 0.004480431 CREB3L3 ENSG00000060566 34.70508624 1.47194589 0.00058517 0.004480511 MAMSTR ENSG00000176909 20.26598649 -1.25836641 0.000585623 0.004481607 UACA ENSG00000137831 784.9333495 0.808869569 0.000587485 0.00449246 FAM218A ENSG00000250486 31.26428243 -1.060472431 0.000587508 0.00449246 AKAP7 ENSG00000118507 1017.205731 0.33848821 0.000592073 0.004522581 MAP2K3 ENSG00000034152 6745.276684 0.431438023 0.000593584 0.004530532 SLC4A3 ENSG00000114923 110.0411968 -1.266182474 0.000595845 0.004545384 GTF2F2 ENSG00000188342 1338.253715 0.469097569 0.000596033 0.004545621 FPR2 ENSG00000171049 2551.011403 0.918658493 0.000596566 0.004547137 TUBE1 ENSG00000074935 1023.235831 -0.475067286 0.000597901 0.00455505 SIK1 ENSG00000142178 3132.430217 0.782860837 0.000598528 0.004558631 PPM1F ENSG00000100034 11253.16455 0.456632541 0.000600365 0.004570208 MORF4L2 ENSG00000123562 4277.863399 0.289504318 0.00060117 0.004572604 TRAF6 ENSG00000175104 2583.00258 0.702609319 0.000600938 0.004572604 EPHX2 ENSG00000120915 1554.789502 -0.762868989 0.000602214 0.004578251 C9orf142 ENSG00000148362 2236.672266 -0.43934012 0.00060393 0.00459009 RYBP ENSG00000163602 6160.888001 0.680567118 0.00060546 0.004600512 OMG ENSG00000126861 389.7825056 0.486866003 0.000609801 0.004627459 SDS ENSG00000135094 104.8399082 1.232964749 0.000609968 0.004627459 COX5B ENSG00000135940 3583.590872 0.350869087 0.000617657 0.004675967 GPR183 ENSG00000169508 4646.947421 0.636870406 0.000619932 0.004690882 EXOSC5 ENSG00000077348 822.0623077 -0.398662052 0.000621608 0.004700948 GPR34 ENSG00000171659 532.7372821 1.125493293 0.000623967 0.004713855 S100PBP ENSG00000116497 2663.786625 -0.603374434 0.000624693 0.004718108 ZKSCAN1 ENSG00000106261 6173.572748 -0.41614748 0.000625553 0.004723363 GNB1 ENSG00000078369 32744.11877 0.237979269 0.000629183 0.004748296 ARHGEF11 ENSG00000132694 6218.002622 0.448950714 0.000630952 0.004759158 ARFGEF2 ENSG00000124198 6582.114853 0.335408255 0.000631942 0.004765384 AFG3L2 ENSG00000141385 3429.291799 0.277501952 0.000633445 0.004775469 DNAJB6 ENSG00000105993 10563.934 0.486686048 0.000638255 0.004807966 EFNB2 ENSG00000125266 28.37162827 -0.934623568 0.000640935 0.004825637 PAPSS2 ENSG00000198682 1190.525998 0.686874392 0.000641281 0.004826982 ZNF594 ENSG00000180626 596.704313 -0.698821657 0.000642082 0.00482924 RIC8A ENSG00000177963 4490.996574 0.316556107 0.000642298 0.004829609 SLC6A8 ENSG00000130821 219.4673518 0.880296005 0.000644087 0.004841796 COL8A2 ENSG00000171812 574.9970002 0.695301737 0.000646745 0.004860513 GNAI2 ENSG00000114353 58615.09762 0.350205069 0.000646949 0.004860782 BICDL1 ENSG00000135127 2599.4995 -0.620769215 0.000647559 0.004863399 LIN7B ENSG00000104863 224.0314027 -0.475344176 0.000648083 0.00486494 ATM ENSG00000149311 26340.83811 -0.664239793 0.000648176 0.00486494 CRTC3 ENSG00000140577 3517.716903 0.454071155 0.000651095 0.004885578 WNK2 ENSG00000165238 21.96884512 1.364188825 0.000656734 0.004922775

DDX5 ENSG00000108654 72412.92733 -0.238675443 0.000658014 0.004929813 DOCK9 ENSG00000088387 3904.535737 -0.535490712 0.00065888 0.004935023 MARCO ENSG00000019169 1771.482152 1.00685205 0.00066257 0.004958804 SLC51A ENSG00000163959 274.4926504 0.518905197 0.000665862 0.004977854 HSBP1 ENSG00000230989 1892.740743 0.430817495 0.000666149 0.004977854 SIGLEC10 ENSG00000142512 7572.751563 0.445081511 0.000666145 0.004977854 C21orf62-AS1 ENSG00000205930 85.36123732 -0.913115004 0.000666671 0.00497918 PCBP1 ENSG00000169564 28315.59474 0.278103928 0.000668355 0.004986602 NXT1 ENSG00000132661 1189.605104 0.576861199 0.000669221 0.004991771 SURF4 ENSG00000148248 11819.53978 0.275888519 0.000669991 0.004996223 TTK ENSG00000112742 132.6560441 1.13113496 0.000670376 0.004997802 ZNF835 ENSG00000127903 38.03912567 -1.273944903 0.000675035 0.005027342 SPRYD3 ENSG00000167778 2233.141559 -0.449352867 0.000675382 0.005027342 PARP10 ENSG00000178685 6114.269012 -0.544664447 0.000675369 0.005027342 BCAM ENSG00000187244 7.280036392 1.597590169 0.00067588 0.005029748 ABHD6 ENSG00000163686 339.3448982 -0.523089368 0.000676818 0.005035433 RTN4R ENSG00000040608 41.6030827 -1.066577755 0.000677675 0.005039219 SRP72 ENSG00000174780 8675.324974 0.332122466 0.000678207 0.005041872 CSRNP1 ENSG00000144655 5887.816815 0.986543289 0.000682481 0.005069734 TRMT10B ENSG00000165275 1278.008357 -0.446811332 0.00068317 0.005073545 NEDD9 ENSG00000111859 6512.956259 0.584311742 0.000683403 0.005073974 KNDC1 ENSG00000171798 301.433507 -1.142688331 0.000686618 0.005095227 TRIM17 ENSG00000162931 163.9539368 -0.654047157 0.000686532 0.005095227 OCIAD2 ENSG00000145247 1211.568366 -0.587851664 0.000690019 0.005112581 UBE2S ENSG00000108106 967.8927325 0.587813202 0.000691065 0.00511902 SLC36A1 ENSG00000123643 3804.939709 0.828486355 0.000691947 0.005123207 NHLRC2 ENSG00000196865 2984.963578 -0.440642286 0.000691985 0.005123207 KAZALD1 ENSG00000107821 25.54791564 1.222271392 0.000692932 0.005127589 RAP1GAP ENSG00000076864 41.06522075 1.404958169 0.000694531 0.00513679 MARVELD1 ENSG00000155254 1601.648165 0.858540516 0.00070284 0.005194256 MND1 ENSG00000121211 47.7035078 1.15709254 0.000708723 0.005228371 ZNF354C ENSG00000177932 923.3319363 -0.549917046 0.00070953 0.005232453 PTDSS1 ENSG00000156471 6588.926271 0.277740221 0.000710025 0.005232453 ING3 ENSG00000071243 2865.883347 0.358326285 0.000709797 0.005232453 BPNT1 ENSG00000162813 957.5600253 -0.577576115 0.000710182 0.005232453 MCAM ENSG00000076706 101.6654397 1.10326914 0.000711744 0.005241289 TPI1 ENSG00000111669 19475.29541 0.326873458 0.00071497 0.005262363 ZNF70 ENSG00000187792 473.9047669 -0.550023584 0.000715881 0.005267455 FGF9 ENSG00000102678 75.32355057 -0.846639405 0.000716827 0.005270698 NAGA ENSG00000198951 8100.582098 0.44699825 0.000718554 0.005280666 KLHL29 ENSG00000119771 394.0268145 0.93460848 0.000719871 0.005287692 PIK3CB ENSG00000051382 2570.49699 0.435866664 0.000719876 0.005287692 WDR70 ENSG00000082068 2883.645604 0.280840773 0.00072096 0.00529162 TGOLN2 ENSG00000152291 14915.24189 0.577771278 0.000723939 0.00530809 EXOSC2 ENSG00000130713 2781.628356 -0.263392778 0.000728775 0.005335427 GDAP1 ENSG00000104381 446.1338214 0.703504692 0.000732071 0.005354126

GLB1L ENSG00000163521 559.4068725 0.571281586 0.000732257 0.00535413 CXCR4 ENSG00000121966 49525.30997 0.734213748 0.000732731 0.00535624 FASLG ENSG00000117560 536.0358967 -1.057557903 0.000733756 0.005362379 CCNC ENSG00000112237 3645.4253 0.318945414 0.000734943 0.005368334 RMDN3 ENSG00000137824 2820.108269 -0.32578675 0.000736968 0.005381766 CACTIN ENSG00000105298 2112.544142 -0.331490078 0.000738989 0.005392438 ULK1 ENSG00000177169 3586.271087 0.483234919 0.000738888 0.005392438 POLR2K ENSG00000147669 2891.570412 0.21954499 0.00074023 0.005398761 C9orf66 ENSG00000183784 138.8094074 0.830868185 0.000741275 0.005405025 MTO1 ENSG00000135297 1860.079632 -0.356855974 0.000743521 0.005417297 TANK ENSG00000136560 4455.124534 0.512682743 0.000747264 0.005436235 SRSF5 ENSG00000100650 26146.15214 -0.244961125 0.000747311 0.005436235 AARS2 ENSG00000124608 1298.059497 -0.469330373 0.00074703 0.005436235 SPATA2L ENSG00000158792 560.7624198 0.570343593 0.000747438 0.005436235 STOML1 ENSG00000067221 380.4048023 -0.500336551 0.000752058 0.005466087 CLCN5 ENSG00000171365 1643.684271 0.622702404 0.00075211 0.005466087 USP42 ENSG00000106346 2190.519912 0.484819153 0.000753667 0.005476026 BRD4 ENSG00000141867 9064.673281 0.386828802 0.000753869 0.005476119 PKIA ENSG00000171033 764.4394586 -0.619043808 0.000755555 0.005484231 TK1 ENSG00000167900 371.6112112 0.742226806 0.000765729 0.005544146 PSMB1 ENSG00000008018 7851.268906 0.232369918 0.000765702 0.005544146 GARS ENSG00000106105 4629.993413 0.260226848 0.000767211 0.005553483 PSMG3 ENSG00000157778 1021.455062 -0.430332582 0.000772079 0.005583126 HDAC8 ENSG00000147099 1181.862835 0.309121685 0.000773078 0.005587557 TCAF1 ENSG00000198420 844.6293411 -0.438934707 0.000773333 0.005587998 ENPEP ENSG00000138792 6.51318968 -1.58990518 0.000775104 0.005599392 RAB39B ENSG00000155961 527.9041622 -0.574322532 0.00077571 0.005602369 FCHO1 ENSG00000130475 3842.460479 -0.31945029 0.000777363 0.005611504 IL24 ENSG00000162892 3343.270971 -0.480150652 0.00077864 0.005616509 TTC9B ENSG00000174521 42.40906276 1.051170443 0.000780396 0.005626371 CHEK2 ENSG00000183765 592.0903516 -0.479148012 0.000781101 0.005630044 HIRIP3 ENSG00000149929 1032.913275 -0.491993296 0.000783728 0.005645058 GEMIN5 ENSG00000082516 915.6579979 -0.433781124 0.00078377 0.005645058 HP1BP3 ENSG00000127483 19937.25658 -0.254381781 0.000789884 0.005684654 HDLBP ENSG00000115677 14382.25067 0.325835356 0.000790055 0.005684654 TOB1 ENSG00000141232 8275.107005 0.712905684 0.000791365 0.005692668 MCM7 ENSG00000166508 6719.487943 -0.385417014 0.000793386 0.005704361 DOPEY2 ENSG00000142197 4299.318198 0.340725287 0.000794039 0.005706642 ANXA7 ENSG00000138279 8640.644067 0.283859987 0.000795881 0.005716607 CDK19 ENSG00000155111 4852.307558 0.410104624 0.000797046 0.005723558 FUNDC2 ENSG00000165775 2348.789199 0.35485622 0.000800136 0.005742887 CAPZA2 ENSG00000198898 5957.408716 0.616329966 0.000802064 0.005755297 IRF6 ENSG00000117595 60.13246204 -1.036280317 0.000809198 0.005797279 NTHL1 ENSG00000065057 378.0008065 -0.50594602 0.000811218 0.005809442 MYOM1 ENSG00000101605 425.6508766 -0.599897066 0.000812806 0.005817924 LAX1 ENSG00000122188 1432.163367 -0.796642138 0.00081278 0.005817924

FRMPD3 ENSG00000147234 454.2627143 -0.800744615 0.000825546 0.005897428 FBXO11 ENSG00000138081 6670.970741 0.326042407 0.000826633 0.005903732 HEATR9 ENSG00000270379 257.8644347 -0.660545498 0.000831521 0.005932557 MAGEH1 ENSG00000187601 716.3809272 -0.576928791 0.000831901 0.005932557 USF2 ENSG00000105698 11160.71686 0.267207173 0.000841949 0.005996809 MAF1 ENSG00000179632 6196.962195 0.327608365 0.000844279 0.006010444 BTD ENSG00000169814 1538.633319 -0.408860855 0.000844954 0.006013763 EPHB6 ENSG00000106123 2151.436139 -0.326549916 0.000848901 0.006037398 LYPD4 ENSG00000273111 9.505943303 1.425171094 0.000851746 0.006051673 LINC00346 ENSG00000255874 22.08761894 -1.38540439 0.000852234 0.006053465 RNASE6 ENSG00000169413 6358.873397 0.594480577 0.000852418 0.006053465 GNLY ENSG00000115523 22427.70341 -0.82563363 0.000854494 0.006066716 SLC16A13 ENSG00000174327 176.405871 -0.89303627 0.000857261 0.006084866 TMEM267 ENSG00000151881 929.380975 -0.444511159 0.000857685 0.006086064 CCNI ENSG00000118816 26899.05515 0.181188287 0.000860077 0.00610036 NCR3 ENSG00000204475 978.6834299 -0.806244061 0.000861002 0.006103923 RECQL ENSG00000004700 3918.12841 -0.371045464 0.000862481 0.006112907 PSMD2 ENSG00000175166 7761.476557 0.198759053 0.000863166 0.00611626 APEH ENSG00000164062 5206.842623 -0.323583629 0.000866614 0.006139189 PCDH12 ENSG00000113555 440.551852 -0.349247529 0.00087173 0.006166355 PPIAL4C ENSG00000263464 30.39691425 -1.177420746 0.000875107 0.006188728 RECQL5 ENSG00000108469 1806.257137 -0.283089107 0.000879669 0.006214905 PTPN3 ENSG00000070159 31.42888634 1.347812037 0.000889732 0.006276874 GTPBP6 ENSG00000178605 3899.937954 -0.30334322 0.000890194 0.006278516 LEMD2 ENSG00000161904 10297.57278 0.534904615 0.00089131 0.006284854 TREM2 ENSG00000095970 21.40731812 1.33750744 0.000894414 0.006303665 UQCRFS1 ENSG00000169021 4257.589769 0.845254936 0.000897814 0.006326084 AIM1 ENSG00000112297 12883.22869 0.486307062 0.000898394 0.006328626 MSN ENSG00000147065 118381.295 0.250565059 0.000900677 0.006341618 CDK5RAP1 ENSG00000101391 2965.987882 -0.240736955 0.000902412 0.006350736 HSPB1 ENSG00000106211 1087.638244 -0.595657206 0.000902266 0.006350736 TEX2 ENSG00000136478 2775.368349 0.544532457 0.000902802 0.006351748 CENPQ ENSG00000031691 298.1477716 -0.660293155 0.000905967 0.006368497 CDADC1 ENSG00000102543 1069.344409 0.419251701 0.000906038 0.006368497 IFI27 ENSG00000165949 162.4744847 1.261331403 0.000907291 0.006371103 ULK3 ENSG00000140474 4759.746692 -0.4117843 0.00090723 0.006371103 FAF2 ENSG00000113194 3872.256357 0.283655822 0.000908495 0.00637801 THG1L ENSG00000113272 1017.86581 0.457217092 0.000910652 0.006387643 KIF9 ENSG00000088727 166.5485896 0.48602681 0.000910758 0.006387643 FAM91A1 ENSG00000176853 4529.106031 0.688971768 0.000911055 0.006387643 ANO6 ENSG00000177119 8989.583735 0.426479474 0.000911415 0.006387643 DAPK2 ENSG00000035664 1225.632178 0.726927881 0.000912105 0.006390933 NEFM ENSG00000104722 18.21850897 -1.272715525 0.000912871 0.006394745 PDE8A ENSG00000073417 3929.35208 0.276512201 0.000916086 0.006414157 TOMM7 ENSG00000196683 8558.819751 -0.515964585 0.000924404 0.006464562 SPATA32 ENSG00000184361 30.17435277 -0.940667925 0.000924902 0.006466477

TMEM187 ENSG00000177854 155.1972142 -0.728466659 0.000931949 0.006507873 USP25 ENSG00000155313 7962.560526 0.278469897 0.000933258 0.006510716 LTBP3 ENSG00000168056 5693.411517 -0.540730378 0.000932832 0.006510716 SUB1 ENSG00000113387 11452.28294 0.411231647 0.00093687 0.006531185 KIF4A ENSG00000090889 121.4882079 1.136192127 0.000936835 0.006531185 FANCD2 ENSG00000144554 2034.122734 -0.348148674 0.000937656 0.006534348 RAB32 ENSG00000118508 3011.056485 0.530835614 0.000937776 0.006534348 EBF4 ENSG00000088881 410.8069788 -0.841611894 0.000946478 0.006583868 TM6SF1 ENSG00000136404 1206.951015 0.584877699 0.000947489 0.006589314 SAT1 ENSG00000130066 81381.26796 0.669847549 0.00095123 0.006612146 IL12RB1 ENSG00000096996 3209.645163 -0.407830904 0.000957644 0.006647135 TLK1 ENSG00000198586 6067.767893 0.325229578 0.000958814 0.006653659 SMPDL3B ENSG00000130768 32.4399944 0.834978605 0.000959109 0.006654105 PPP1R3D ENSG00000132825 970.9386239 0.619161714 0.000959915 0.006658097 CREB3L4 ENSG00000143578 441.1719198 -0.358299112 0.000962693 0.006675765 UPF3A ENSG00000169062 5702.076015 -0.240902449 0.000962931 0.006675814 CDC20 ENSG00000117399 189.1650442 1.056932743 0.00096399 0.006679949 AJAP1 ENSG00000196581 37.97984654 -1.181207597 0.000965576 0.006689337 TRPS1 ENSG00000104447 3143.377208 0.602027751 0.000966617 0.006691734 SLC7A11 ENSG00000151012 90.02954034 0.963236972 0.000966541 0.006691734 NUP205 ENSG00000155561 4783.578155 -0.220416536 0.000968616 0.006699146 PTS ENSG00000150787 1606.092799 0.474712768 0.000968984 0.006700088 MTSS1L ENSG00000132613 413.3311495 0.692493951 0.000970238 0.006707154 RNMT ENSG00000101654 2482.086514 0.581760721 0.000975283 0.006735586 MKI67 ENSG00000148773 1729.73405 1.015961231 0.000975649 0.006736498 HMMR ENSG00000072571 170.1775148 0.976779513 0.000979908 0.006764289 COMMD9 ENSG00000110442 3289.305947 0.402075152 0.00098352 0.00678598 SLAIN1 ENSG00000139737 968.7911948 -0.403406057 0.00098432 0.006789882 RPAP2 ENSG00000122484 2195.647041 -0.618955792 0.000988166 0.006813159 CLEC11A ENSG00000105472 281.0015566 0.78931349 0.00098892 0.006816731 HPRT1 ENSG00000165704 1760.93321 0.328629461 0.000994304 0.006847307 CPPED1 ENSG00000103381 9509.295282 0.584748565 0.000998748 0.006872991 RAB3A ENSG00000105649 139.8308317 0.551344746 0.000999279 0.006875009 DCANP1 ENSG00000251380 54.65100747 -1.417296599 0.001001934 0.006888355 SUSD4 ENSG00000143502 285.9228258 -0.882476976 0.001002731 0.006892194 NARS2 ENSG00000137513 408.9694036 -0.457951826 0.001003891 0.006898526 VAV2 ENSG00000160293 1757.837234 0.35914509 0.001004908 0.006903876 MAP3K9 ENSG00000006432 585.4070816 -0.585408011 0.001011761 0.006940481 RP11-867G23.8 ENSG00000255468 40.59206294 -0.894983845 0.001015161 0.006961067 CECR6 ENSG00000183307 681.7181218 0.715194167 0.001018894 0.006981697 SLC25A17 ENSG00000100372 983.6478379 -0.423093194 0.001022186 0.007000933 ZBED4 ENSG00000100426 4961.886537 0.449761011 0.001028192 0.007037315 TMEM99 ENSG00000167920 110.5076913 -0.849949438 0.001029651 0.007045379 GAS2 ENSG00000148935 61.22990683 -0.858835339 0.001035245 0.007076952 REPS1 ENSG00000135597 4281.077144 0.215246431 0.001035932 0.007077992 EFHC2 ENSG00000183690 311.1295631 -0.624238086 0.001037494 0.007083946

UST ENSG00000111962 534.4318588 -0.589033208 0.00104115 0.007103871 SLC25A32 ENSG00000164933 2145.974045 0.322717421 0.001041583 0.007105146 SPTY2D1 ENSG00000179119 3315.86527 0.389379834 0.001042364 0.007108793 HS3ST3B1 ENSG00000125430 1276.252995 -0.567460236 0.001045064 0.007123841 KIF5C ENSG00000168280 652.8949718 -0.665873021 0.001046766 0.007133764 ATP6V1H ENSG00000047249 1477.401172 0.239560455 0.001057618 0.007200927 CDAN1 ENSG00000140326 1633.071175 -0.347351706 0.001060759 0.00721551 SPON1 ENSG00000262655 156.389833 -0.643520039 0.001060283 0.00721551 ERCC4 ENSG00000175595 730.2796391 -0.396785052 0.001065721 0.007244147 FAM150B ENSG00000189292 17.22191079 -1.376577007 0.001066925 0.007250622 NEIL2 ENSG00000154328 758.2676092 -0.560243217 0.001067433 0.007252258 MTMR4 ENSG00000108389 5462.522676 -0.258560821 0.001067668 0.007252258 CAPN5 ENSG00000149260 392.2311781 -0.714314719 0.001076923 0.007304819 MKNK2 ENSG00000099875 10777.14676 0.47687016 0.001083724 0.007341272 RAP2C ENSG00000123728 6456.708638 0.40243388 0.001083822 0.007341272 PEX5 ENSG00000139197 1369.917701 -0.401247665 0.001086861 0.007358409 TAX1BP1 ENSG00000106052 10823.29362 0.278219314 0.001087189 0.007358903 CDC45 ENSG00000093009 166.9221063 1.036838246 0.001090295 0.00737647 CFAP46 ENSG00000171811 72.94964666 -0.888769522 0.001092914 0.00739073 LRRK2 ENSG00000188906 17774.49451 0.628542032 0.001093708 0.007394369 HK1 ENSG00000156515 13460.7595 0.416101775 0.001095245 0.007401294 TBC1D22A ENSG00000054611 4295.61318 0.237168587 0.001097388 0.007412306 RP11-867G23.8 ENSG00000255468 10.8211648 -1.013860731 0.001105614 0.007459153 FMN1 ENSG00000248905 1753.055839 0.985197245 0.0011064 0.007461259 YPEL2 ENSG00000175155 2545.419427 1.151171532 0.001111341 0.007489042 IGFBP2 ENSG00000115457 62.96463041 1.429169648 0.001113959 0.007504938 WDR27 ENSG00000184465 1152.591092 -0.360124531 0.00111624 0.007516796 NAE1 ENSG00000159593 2801.609974 -0.238862529 0.001117078 0.007520685 EXTL2 ENSG00000162694 347.451438 -0.492230783 0.001117959 0.007524655 MCPH1 ENSG00000147316 2568.9135 0.250157134 0.001118188 0.007524655 OLAH ENSG00000152463 16.13887146 1.530528251 0.0011214 0.007540996 XCR1 ENSG00000173578 58.93567452 -1.0246284 0.001122202 0.007544635 ARHGEF9 ENSG00000131089 2126.256 -0.36737372 0.001128044 0.007576858 ESPL1 ENSG00000135476 225.404769 0.972198953 0.001130492 0.007589932 CCDC150 ENSG00000144395 67.28431447 0.900604652 0.001133784 0.007605112 HAL ENSG00000084110 3150.627863 0.741227279 0.001136095 0.007614998 BAZ1A ENSG00000198604 9754.165185 0.410468836 0.001139825 0.007636455 ITPA ENSG00000125877 2664.623421 -0.328711709 0.00115129 0.007706122 WDR46 ENSG00000227057 2863.331819 -0.294383034 0.001156613 0.007733762 FAM153A ENSG00000170074 2455.316816 -0.684280848 0.001162045 0.00776013 CACNA1H ENSG00000196557 237.7228781 -0.723024614 0.00116181 0.00776013 MAPT ENSG00000186868 60.22273951 -0.619756025 0.001164643 0.007773886 ESYT2 ENSG00000117868 16417.33779 -0.211964404 0.001166662 0.007785561 HMGB1 ENSG00000189403 18670.0696 0.289591241 0.001167265 0.007787789 SH3RF3 ENSG00000172985 353.8939494 0.594389058 0.001174194 0.007828594 ZBTB34 ENSG00000177125 4221.201441 0.469786001 0.001177673 0.007848136

ZNF441 ENSG00000197044 1034.95423 -0.494190487 0.001178646 0.007851029 GSPT1 ENSG00000103342 8994.812823 0.409953346 0.001179459 0.007854629 RHOB ENSG00000143878 5496.78976 -0.637462167 0.001182817 0.007866706 M1AP ENSG00000159374 175.7644066 0.824899799 0.001182906 0.007866706 TMEM129 ENSG00000168936 2035.939187 -0.402284338 0.001185423 0.007879031 ALPK1 ENSG00000073331 4706.164532 0.621883022 0.001188334 0.007895533 NEMF ENSG00000165525 6841.743477 0.291132222 0.001191038 0.007908043 RAB11FIP3 ENSG00000090565 2798.332976 -0.448249712 0.001190807 0.007908043 ID3 ENSG00000117318 222.8090144 -0.936075436 0.00119406 0.007920827 NDFIP1 ENSG00000131507 11323.43595 0.334147197 0.001195333 0.007927451 ZNF486 ENSG00000256229 476.5315485 -0.615642287 0.001196951 0.007936361 PAX6 ENSG00000007372 258.115062 -0.478724881 0.001203197 0.007970454 PATL1 ENSG00000166889 8150.660454 0.449879556 0.001207285 0.007993873 ZNF189 ENSG00000136870 1233.464771 -0.37950384 0.001207163 0.007993873 SNRPA1 ENSG00000131876 4979.186796 0.41876558 0.00120872 0.00800154 GPR180 ENSG00000152749 1134.810042 -0.434078196 0.001209911 0.008005756 PPID ENSG00000171497 2825.601109 -0.245477952 0.00121052 0.008006117 PAPD4 ENSG00000164329 9321.750312 0.271832808 0.001218498 0.008049666 RLN3 ENSG00000171136 38.13823751 1.475087345 0.001227666 0.008106522 MARCH1 ENSG00000145416 6804.624168 0.642109304 0.001232912 0.008137442 MELK ENSG00000165304 152.0217779 0.992090873 0.001241602 0.008191057 PPP1R15A ENSG00000087074 24430.72177 0.733597769 0.001244289 0.008205036 PRSS22 ENSG00000005001 18.21442411 -1.232162978 0.00124569 0.008206782 SLC25A45 ENSG00000162241 3378.975981 -0.368039484 0.001245125 0.008206782 MIGA2 ENSG00000148343 3299.235424 -0.293708796 0.001247657 0.008217864 KIAA1522 ENSG00000162522 381.210281 0.816770346 0.001249458 0.008227856 HOMER1 ENSG00000152413 107.6385625 -0.655123708 0.001253129 0.008248264 PBK ENSG00000168078 49.69347312 1.307697722 0.001254749 0.008256045 ZNF267 ENSG00000185947 3106.2697 0.803071493 0.001256908 0.008265605 TMTC2 ENSG00000179104 1663.512886 0.43851872 0.001260922 0.00828483 GUCY1A3 ENSG00000164116 161.1084334 -0.972764267 0.001263681 0.008298816 CPEB3 ENSG00000107864 1026.376186 0.496949905 0.001265541 0.008309141 DEK ENSG00000124795 11106.73233 0.541072092 0.001271474 0.008344304 C1orf131 ENSG00000143633 991.0842612 -0.4438738 0.001275819 0.008363314 INO80 ENSG00000128908 4754.656919 0.309481207 0.001277143 0.008370095 ABCA13 ENSG00000179869 1329.203978 1.424273947 0.001278079 0.008374332 NOL8 ENSG00000198000 5144.315564 -0.262201302 0.001280823 0.008387436 MEAF6 ENSG00000163875 2753.721117 -0.278524907 0.001280749 0.008387436 MCUB ENSG00000005059 5303.352517 0.256535216 0.001288429 0.008424951 MAN2A2 ENSG00000196547 15667.42372 0.547775004 0.001291982 0.008440539 CYB5R1 ENSG00000159348 2296.629854 0.284167297 0.001293655 0.008447649 TMEM117 ENSG00000139173 146.5725825 -0.641779705 0.001295445 0.008451696 KDF1 ENSG00000175707 51.00269969 -0.93199496 0.001294861 0.008451696 GM2A ENSG00000196743 4100.045394 1.019830759 0.00129681 0.008455464 ZC3H13 ENSG00000123200 6232.879935 -0.348221567 0.001303291 0.008495212 NRDC ENSG00000078618 17298.36162 0.26768403 0.001305128 0.008505267

PJA2 ENSG00000198961 12417.03475 0.38409311 0.001306222 0.008506829 NKIRAS2 ENSG00000168256 3491.842475 0.472592547 0.001306251 0.008506829 LMOD2 ENSG00000170807 34.51332047 1.224083041 0.001307495 0.008512466 FBN1 ENSG00000166147 137.1743486 1.072280706 0.001307706 0.008512466 KIAA0368 ENSG00000136813 8448.405726 0.225115222 0.001309972 0.008521453 IL2RB ENSG00000100385 15450.05425 -0.754043546 0.001319778 0.008576434 UBAC1 ENSG00000130560 3166.80142 0.345547657 0.001321905 0.008585549 MAPKAP1 ENSG00000119487 5625.545248 0.312044092 0.001324155 0.008594364 KIF5A ENSG00000155980 86.61802026 -0.85370015 0.001324806 0.008596658 SLC25A6 ENSG00000169100 32636.46132 0.31549541 0.001335886 0.008653008 RAB21 ENSG00000080371 4057.371008 0.568646189 0.001341614 0.008688159 NOSTRIN ENSG00000163072 8.822319571 1.298225276 0.001356348 0.00877178 SNRPF ENSG00000139343 1693.089596 0.297335486 0.001356718 0.008772209 ABHD8 ENSG00000127220 681.100988 0.39035478 0.001363569 0.008807445 SPRY1 ENSG00000164056 108.0685095 0.941033475 0.001366786 0.008823484 MAP7D1 ENSG00000116871 11040.46427 0.368821491 0.001366655 0.008823484 KIAA0232 ENSG00000170871 6790.63864 0.364452503 0.001367509 0.008826176 TSPAN6 ENSG00000000003 29.5667623 -0.945137197 0.001367826 0.008826253 ATG3 ENSG00000144848 8829.524274 0.38022095 0.001368735 0.008827905 IFNG ENSG00000111537 379.2509167 -0.955173796 0.001371368 0.008841208 GDE1 ENSG00000006007 3378.731818 0.402845079 0.001372992 0.008847729 GZMM ENSG00000197540 2890.685528 -0.825813471 0.001375907 0.008862908 RP9 ENSG00000164610 1102.769013 -0.295033375 0.001377188 0.008862908 EPS8L2 ENSG00000177106 194.7566427 -0.764777697 0.001379471 0.008875623 BCL9L ENSG00000186174 13645.54906 -0.468778725 0.001379978 0.008876906 MTERF2 ENSG00000120832 1162.862475 -0.531594818 0.001381248 0.008883101 UBE2I ENSG00000103275 6716.113066 0.283152623 0.001383915 0.008896286 ZNF461 ENSG00000197808 627.1886875 -0.385689323 0.001387937 0.008914925 ANXA3 ENSG00000138772 3382.230236 1.26879377 0.001393256 0.008942409 WNT3 ENSG00000108379 51.35656043 -1.117689235 0.001395047 0.00894842 PRDX3 ENSG00000165672 5836.806531 0.421586783 0.001399114 0.008966062 SH2B3 ENSG00000111252 15514.73293 0.488669386 0.001402264 0.008982261 VNN2 ENSG00000112303 16773.19254 0.648297133 0.00140677 0.009002604 TMIGD2 ENSG00000167664 754.7451047 -0.614493529 0.001412152 0.009031582 CMC1 ENSG00000187118 4191.037805 -0.266826413 0.001412879 0.009034234 TBX3 ENSG00000135111 7.738870475 1.494304441 0.001423633 0.009098969 E2F8 ENSG00000129173 106.0985903 1.232305257 0.001427168 0.009117524 PLCB1 ENSG00000182621 1360.671875 0.580225293 0.00142807 0.009120556 AMOTL1 ENSG00000166025 222.0032052 0.62910281 0.001430018 0.009129675 AP5B1 ENSG00000254470 7441.043736 0.582515832 0.001430447 0.0091304 RPS27A ENSG00000143947 55998.92274 -0.342166148 0.001431096 0.009132526 EAPP ENSG00000129518 3487.264851 0.305126137 0.001434482 0.009151608 RAG1 ENSG00000166349 70.73451856 -0.716448652 0.001436431 0.009156835 SOX13 ENSG00000143842 810.3585067 -0.79154753 0.001436491 0.009156835 FSD1 ENSG00000105255 175.3865279 -0.817278824 0.001445314 0.009202928 HYDIN ENSG00000157423 27.86405257 -1.480851788 0.001445016 0.009202928

AGTRAP ENSG00000177674 4475.956745 0.40381315 0.001449666 0.009223636 DGCR8 ENSG00000128191 2872.844994 -0.377208624 0.001451225 0.009228362 TMIE ENSG00000181585 45.07535118 -1.095858105 0.001454548 0.009245422 DDO ENSG00000203797 162.4652851 0.714928486 0.001468455 0.009319915 FBXL18 ENSG00000155034 268.2261958 0.562992333 0.001468526 0.009319915 GKAP1 ENSG00000165113 478.6282928 -0.416242358 0.001481062 0.009389161 CETN2 ENSG00000147400 1293.704732 0.357343678 0.00148244 0.009395834 NEK9 ENSG00000119638 8319.44349 -0.367310628 0.001485342 0.009410095 TMEM57 ENSG00000204178 2966.881788 0.460049049 0.00148651 0.009415435 MKL1 ENSG00000196588 7491.248269 0.210663703 0.001487794 0.009421502 RAB18 ENSG00000099246 3956.896156 0.466521191 0.001493696 0.009452658 SLC39A14 ENSG00000104635 460.9150023 -0.544020869 0.001495877 0.009464085 KIAA2022 ENSG00000050030 45.1067737 -1.170455242 0.001496718 0.009465561 FOXC1 ENSG00000054598 20.65516149 1.310952119 0.00149924 0.009475288 PKP2 ENSG00000057294 248.9691669 0.952959522 0.001508214 0.009521592 ZNF285 ENSG00000267508 124.5866436 -1.023456676 0.001508774 0.009522064 PARL ENSG00000175193 3036.773966 0.294770905 0.001508948 0.009522064 TAMM41 ENSG00000144559 757.1512362 -0.411399767 0.001510248 0.009528183 C4orf3 ENSG00000164096 8894.226999 0.297357372 0.001511701 0.009535269 ZNF613 ENSG00000176024 224.0141741 -0.562254174 0.001514108 0.009548364 GAS6 ENSG00000183087 1030.883988 0.645569252 0.001515784 0.009556851 HIST2H4B ENSG00000270276 241.2919484 -0.543512868 0.001518707 0.009573191 NET1 ENSG00000173848 969.6169179 0.594468553 0.001521024 0.009585702 EMX1 ENSG00000135638 22.00477009 1.226588542 0.001523436 0.00959881 TMEM9B ENSG00000175348 3504.263972 0.474947108 0.001536511 0.009676974 ATG9B ENSG00000181652 294.0024029 -0.660425251 0.001537954 0.009683946 TNRC6C ENSG00000078687 3022.112038 -0.487782814 0.001541523 0.009695852 UQCRC2 ENSG00000140740 11338.68531 0.179536952 0.001543371 0.009701139 MGAT2 ENSG00000168282 1867.633637 -0.454977255 0.001546693 0.009715683 WBP11 ENSG00000084463 6071.14785 0.325662908 0.001547664 0.009717701 ROCK1 ENSG00000067900 12868.26012 0.445609218 0.001549663 0.009727993 FAM216A ENSG00000204856 718.0620647 -0.377535361 0.001554152 0.009754049 MTRNR2L8 ENSG00000255823 131.8708117 0.63936902 0.001562892 0.009806772 KANK2 ENSG00000197256 102.684912 0.60848445 0.001567447 0.009826818 SPET10 ENSG00000186522 443.2562863 0.651576883 0.001571359 0.009844935 FXR1 ENSG00000114416 7407.317345 0.220607614 0.001571298 0.009844935 RELB ENSG00000104856 1954.058064 0.54551239 0.001584923 0.009919158 CEP19 ENSG00000174007 421.4484385 -0.665236988 0.001590269 0.00994615 FTSJ3 ENSG00000108592 3768.795286 -0.304847965 0.001596983 0.00998104 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 9. Significantly differential expressed genes in the comparison of ACHD with LC

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (ACHD/LC) adjustedb

BCL11A ENSG00000119866 2322.545743 1.17653217 8.91E-19 2.31E-14 CCL5 ENSG00000271503 25750.89146 -1.844623313 1.73E-14 1.52E-10 YPEL2 ENSG00000175155 2210.238552 2.337046169 3.92E-14 1.79E-10 TTC22 ENSG00000006555 1326.374019 -1.630546648 4.13E-14 1.79E-10 NR4A3 ENSG00000119508 312.7972467 2.674273377 4.60E-13 1.49E-09 ANKRD34A ENSG00000272031 173.2308249 -1.142186492 2.24E-12 6.09E-09 CLIC3 ENSG00000169583 1193.385801 -1.95219442 2.38E-12 6.09E-09 DDX21 ENSG00000165732 15757.63582 1.087312484 2.68E-12 6.09E-09 PDGFB ENSG00000100311 369.6892401 -1.811086246 6.76E-12 1.25E-08 PABPC1 ENSG00000070756 111380.9351 0.560838584 1.08E-11 1.86E-08 SPIRE2 ENSG00000204991 455.3478279 -1.527267547 1.40E-11 2.14E-08 TBX21 ENSG00000073861 7601.623579 -1.843497355 3.54E-11 4.79E-08 RIPK2 ENSG00000104312 3923.329898 1.140942826 7.81E-11 8.81E-08 EOMES ENSG00000163508 2198.451698 -2.038634818 1.27E-10 1.27E-07 PLEKHF1 ENSG00000166289 1079.113787 -1.998109549 1.25E-10 1.27E-07 ZNF74 ENSG00000185252 731.1106272 -1.219859412 1.27E-10 1.27E-07 TUBB4A ENSG00000104833 134.9720892 -1.600478275 1.76E-10 1.57E-07 PRSS23 ENSG00000150687 1866.310054 -2.022111882 1.94E-10 1.68E-07 FCRLB ENSG00000162746 163.3847537 -1.670492096 2.00E-10 1.68E-07 GZMM ENSG00000197540 4106.51877 -1.721217471 2.13E-10 1.73E-07 YOD1 ENSG00000180667 5277.332061 1.277947219 2.71E-10 2.13E-07 RGS9 ENSG00000108370 1028.934601 -1.815356495 2.91E-10 2.22E-07 UBE2E2 ENSG00000182247 1407.430213 1.10244268 3.01E-10 2.23E-07 RGS3 ENSG00000138835 3941.328728 -1.212258806 3.24E-10 2.34E-07 FRMPD3 ENSG00000147234 483.6602185 -1.819694168 6.23E-10 4.26E-07 CTSW ENSG00000172543 16356.03813 -1.547865855 7.55E-10 4.79E-07 ZMYND10 ENSG00000004838 357.7773635 -1.550901594 7.56E-10 4.79E-07 CDIP1 ENSG00000089486 2729.511818 -0.833560243 8.41E-10 5.08E-07 SLC30A1 ENSG00000170385 4957.019884 1.241877785 1.15E-09 6.77E-07 GRK3 ENSG00000100077 6888.463737 0.983935802 1.25E-09 6.77E-07 C18orf25 ENSG00000152242 5278.21892 0.779324598 1.30E-09 6.77E-07 FOXD2 ENSG00000186564 121.676185 -1.209847695 1.47E-09 7.43E-07 AGAP2 ENSG00000135439 4652.846099 -0.980290813 1.49E-09 7.43E-07 LAG3 ENSG00000089692 1168.209194 -1.436619485 1.70E-09 8.34E-07 RINL ENSG00000187994 2666.964435 -0.933988047 2.32E-09 1.04E-06 RIOK3 ENSG00000101782 8314.593975 1.166269887 2.33E-09 1.04E-06 TBKBP1 ENSG00000198933 2724.797392 -1.181391812 3.35E-09 1.38E-06 ENPP5 ENSG00000112796 353.2927374 -1.89103523 4.12E-09 1.57E-06 CST7 ENSG00000077984 13309.02176 -1.656433089 4.77E-09 1.73E-06 TRIM17 ENSG00000162931 144.7189213 -1.00770092 5.18E-09 1.82E-06 SERTAD2 ENSG00000179833 8104.346371 1.03833502 5.77E-09 1.97E-06 TTC16 ENSG00000167094 1435.362207 -1.610074531 6.29E-09 2.12E-06

MATK ENSG00000007264 5323.209963 -1.493513158 6.56E-09 2.18E-06 CEP89 ENSG00000121289 1156.030428 -1.003914945 7.20E-09 2.34E-06 METRN ENSG00000103260 216.5164726 -1.304829403 7.50E-09 2.40E-06 FANCE ENSG00000112039 620.6364256 -1.08280749 9.87E-09 2.94E-06 KANK3 ENSG00000186994 126.8481573 -1.681467709 1.01E-08 2.98E-06 NCR3 ENSG00000204475 1113.491594 -1.481175537 1.14E-08 3.32E-06 ZNF786 ENSG00000197362 786.1980336 -0.848947289 1.18E-08 3.41E-06 CCDC102A ENSG00000135736 599.5216595 -1.423217864 1.22E-08 3.45E-06 SNRPA1 ENSG00000131876 5042.149005 0.75229652 1.37E-08 3.78E-06 SOX13 ENSG00000143842 997.522887 -1.43949623 1.65E-08 4.42E-06 SPON2 ENSG00000159674 8097.675999 -1.401096806 2.00E-08 5.19E-06 GPR68 ENSG00000119714 736.2360121 -1.291806431 2.23E-08 5.66E-06 CDYL2 ENSG00000166446 1677.750053 0.838813676 2.48E-08 6.24E-06 TFRC ENSG00000072274 6424.282728 0.702515184 2.58E-08 6.33E-06 NMUR1 ENSG00000171596 2938.924881 -2.092327217 2.54E-08 6.33E-06 C19orf25 ENSG00000119559 1163.548853 -0.958826384 2.58E-08 6.33E-06 GDF11 ENSG00000135414 1089.441408 -1.097176492 2.62E-08 6.36E-06 NPRL2 ENSG00000114388 2490.712863 -0.714342738 2.70E-08 6.48E-06 GPCPD1 ENSG00000125772 23681.91078 0.817785105 2.90E-08 6.78E-06 BCL3 ENSG00000069399 7710.578894 1.589095888 2.98E-08 6.84E-06 TIGD7 ENSG00000140993 634.6676712 -1.03199366 3.01E-08 6.85E-06 GNLY ENSG00000115523 33492.46573 -1.481861424 3.26E-08 7.23E-06 TKTL2 ENSG00000151005 53.15944179 2.142600772 3.25E-08 7.23E-06 TBC1D10C ENSG00000175463 19713.03535 -0.91001272 3.46E-08 7.55E-06 LLGL2 ENSG00000073350 4269.572287 -1.372959877 3.75E-08 8.04E-06 ERBB2 ENSG00000141736 1499.941156 -1.559076317 4.13E-08 8.72E-06 FCRL6 ENSG00000181036 3888.216715 -1.745904776 4.63E-08 9.45E-06 ICAM1 ENSG00000090339 8962.642287 1.745823457 4.70E-08 9.52E-06 B3GAT1 ENSG00000109956 2032.881495 -1.794417413 5.78E-08 1.15E-05 SDE2 ENSG00000143751 3405.475856 0.860059549 6.20E-08 1.21E-05 FASLG ENSG00000117560 573.2460822 -1.91424223 7.20E-08 1.30E-05 USP3 ENSG00000140455 17065.72214 0.771076052 7.18E-08 1.30E-05 DCLRE1A ENSG00000198924 704.5601614 -1.033537615 7.42E-08 1.32E-05 RAD9A ENSG00000172613 2452.038307 -0.761139077 7.89E-08 1.39E-05 CD36 ENSG00000135218 24861.38535 1.544825722 8.74E-08 1.51E-05 TRIM68 ENSG00000167333 940.2956994 -0.913830678 9.00E-08 1.53E-05 FAM43A ENSG00000185112 493.5480865 -1.389172452 9.01E-08 1.53E-05 NLRP3 ENSG00000162711 8310.820879 1.274382501 9.11E-08 1.54E-05 RAB29 ENSG00000117280 7132.844231 -0.787957065 9.21E-08 1.54E-05 IL2RB ENSG00000100385 16616.64856 -1.268646331 9.34E-08 1.55E-05 ATP1A3 ENSG00000105409 751.4648113 -1.231556651 9.66E-08 1.59E-05 ADAM9 ENSG00000168615 2537.264508 1.043401523 1.02E-07 1.67E-05 ASAP1 ENSG00000153317 9528.884628 0.740763246 1.13E-07 1.83E-05 FAM83G ENSG00000188522 781.2661648 -1.226236189 1.21E-07 1.95E-05 RAB20 ENSG00000139832 2563.707106 1.581733465 1.40E-07 2.20E-05 XCL2 ENSG00000143185 571.1838635 -1.627609577 1.46E-07 2.27E-05

HTRA2 ENSG00000115317 1726.078523 -0.607393426 1.47E-07 2.28E-05 TIGD5 ENSG00000179886 640.5527991 -1.057227674 1.50E-07 2.29E-05 GNA15 ENSG00000060558 4350.953705 1.14173175 1.52E-07 2.30E-05 ANKRD22 ENSG00000152766 619.1739419 1.951609654 1.56E-07 2.33E-05 SORT1 ENSG00000134243 8404.695381 1.078302289 1.60E-07 2.37E-05 GRASP ENSG00000161835 5394.569412 1.899404986 1.64E-07 2.37E-05 PKD2L2 ENSG00000078795 764.007958 0.880065873 1.65E-07 2.37E-05 MFSD14A ENSG00000156875 6838.522451 0.575367767 1.78E-07 2.55E-05 LTBP4 ENSG00000090006 3798.519646 -0.967917338 1.84E-07 2.62E-05 MON1A ENSG00000164077 663.8587656 -1.248402429 1.95E-07 2.76E-05 KIAA1161 ENSG00000164976 50.84683887 -1.370429395 1.97E-07 2.77E-05 GLB1L2 ENSG00000149328 438.1700689 -1.731139684 2.00E-07 2.81E-05 C16orf87 ENSG00000155330 1420.705943 0.843674924 2.14E-07 2.98E-05 JRKL ENSG00000183340 802.50514 -1.076544448 2.15E-07 2.98E-05 SBK1 ENSG00000188322 3125.004075 -1.28073363 2.21E-07 3.00E-05 LTA4H ENSG00000111144 35228.27138 1.005741585 2.20E-07 3.00E-05 PROCR ENSG00000101000 137.4239017 -1.052151948 2.21E-07 3.00E-05 FBN2 ENSG00000138829 1726.852064 1.325721871 2.33E-07 3.13E-05 TCN2 ENSG00000185339 2370.798162 1.704062312 2.39E-07 3.20E-05 CREG1 ENSG00000143162 11618.94405 1.091196698 2.48E-07 3.28E-05 CSDE1 ENSG00000009307 46025.85953 0.508988706 2.76E-07 3.60E-05 TPRG1 ENSG00000188001 303.8419923 -1.253061066 2.79E-07 3.61E-05 RAB13 ENSG00000143545 785.4221415 1.406608 2.94E-07 3.74E-05 DNAAF2 ENSG00000165506 637.5377611 -0.914489373 2.92E-07 3.74E-05 CERS6 ENSG00000172292 4962.773105 0.807338911 2.93E-07 3.74E-05 ARL5B ENSG00000165997 4394.46724 1.11280344 3.07E-07 3.89E-05 MLXIPL ENSG00000009950 20.47358347 2.374918946 3.13E-07 3.95E-05 TACC1 ENSG00000147526 8453.50523 1.364584046 3.23E-07 4.00E-05 TCTN2 ENSG00000168778 338.3043409 -1.083504908 3.33E-07 4.06E-05 ZNF692 ENSG00000171163 2548.474718 -0.751603358 3.37E-07 4.07E-05 KIAA0922 ENSG00000121210 11984.73722 0.800410056 3.37E-07 4.07E-05 FZD5 ENSG00000163251 143.3650186 1.322922221 3.41E-07 4.09E-05 ETF1 ENSG00000120705 7889.947893 0.830257457 3.71E-07 4.38E-05 MAFB ENSG00000204103 17773.05747 1.77351335 3.99E-07 4.64E-05 TNFRSF21 ENSG00000146072 476.4959549 1.564052147 3.98E-07 4.64E-05 HSPA12B ENSG00000132622 287.9917447 1.513366009 4.31E-07 4.97E-05 COLGALT2 ENSG00000198756 499.7588798 -1.549003042 4.36E-07 5.01E-05 CELSR3 ENSG00000008300 769.24237 -0.715480643 4.45E-07 5.07E-05 BRD8 ENSG00000112983 3389.9376 -0.70242991 4.54E-07 5.12E-05 PLEKHG3 ENSG00000126822 7344.101943 -1.166212861 4.76E-07 5.28E-05 MASTL ENSG00000120539 1260.143619 1.014051524 4.85E-07 5.36E-05 MYRF ENSG00000124920 380.2892428 -1.199264676 4.95E-07 5.45E-05 PLBD1 ENSG00000121316 32798.70121 1.257232477 5.05E-07 5.51E-05 ILKAP ENSG00000132323 5560.737092 0.619614804 5.11E-07 5.55E-05 DENND1A ENSG00000119522 7093.470266 0.839133837 5.32E-07 5.68E-05 FAM20C ENSG00000177706 2077.670359 1.368202658 5.31E-07 5.68E-05

LEXM ENSG00000162398 284.224046 -1.607937487 5.32E-07 5.68E-05 TMEM167A ENSG00000174695 12038.52904 0.82932613 5.94E-07 6.22E-05 FOXO3 ENSG00000118689 8465.901739 1.211527344 6.00E-07 6.23E-05 LGR6 ENSG00000133067 2111.578584 -1.647744461 6.10E-07 6.31E-05 ZNF582 ENSG00000018869 226.1232513 -1.100970703 6.22E-07 6.35E-05 TRPV4 ENSG00000111199 208.199738 1.336537988 6.42E-07 6.47E-05 WDCP ENSG00000163026 598.1848942 -0.93707599 6.49E-07 6.49E-05 C1orf21 ENSG00000116667 2639.462895 -1.505030802 6.55E-07 6.51E-05 ZNF232 ENSG00000167840 394.6516532 -0.957406318 7.01E-07 6.94E-05 RGS14 ENSG00000169220 8983.436436 -0.809506379 7.06E-07 6.97E-05 RALGDS ENSG00000160271 11628.53853 -0.833149391 7.23E-07 7.11E-05 FCHSD2 ENSG00000137478 8167.704012 0.663477684 8.01E-07 7.75E-05 CLIC4 ENSG00000169504 4313.7557 0.891998306 8.56E-07 8.17E-05 SLAMF6 ENSG00000162739 9131.166069 -1.264641119 8.90E-07 8.44E-05 MPP1 ENSG00000130830 9041.119748 1.495485581 9.05E-07 8.45E-05 SNN ENSG00000184602 16154.4321 1.095550718 9.04E-07 8.45E-05 PXMP4 ENSG00000101417 722.0448876 -0.792410284 9.01E-07 8.45E-05 TMEM167B ENSG00000215717 8867.435339 0.788603827 9.18E-07 8.54E-05 FAM183BP ENSG00000164556 191.7117949 1.713243059 9.25E-07 8.58E-05 FBXO2 ENSG00000116661 272.7068544 -1.344949231 9.42E-07 8.70E-05 SDC3 ENSG00000162512 859.5436005 1.29679487 9.54E-07 8.78E-05 ZBTB21 ENSG00000173276 1752.724025 0.755806723 9.62E-07 8.79E-05 DNAJA2 ENSG00000069345 4850.794663 0.591030731 9.74E-07 8.87E-05 IMP3 ENSG00000177971 2556.724916 -0.850423272 1.00E-06 9.10E-05 ALCAM ENSG00000170017 2529.511623 0.907339526 1.01E-06 9.14E-05 MTHFD2 ENSG00000065911 4256.291608 0.820111712 1.02E-06 9.19E-05 C9orf142 ENSG00000148362 3313.378367 -0.840569101 1.14E-06 0.000101013 LACTB ENSG00000103642 3879.746921 0.921064345 1.21E-06 0.000105194 TONSL ENSG00000160949 765.4501117 -0.922173038 1.22E-06 0.000105375 SIGIRR ENSG00000185187 10977.1989 -0.761788451 1.26E-06 0.000109027 SLC26A11 ENSG00000181045 2522.412656 -0.661555669 1.29E-06 0.000110426 THEM6 ENSG00000130193 905.0430885 -1.070916016 1.34E-06 0.000113945 ZNF425 ENSG00000204947 98.45616226 -1.34688347 1.39E-06 0.000117114 TFAP2E ENSG00000116819 1393.122541 -0.719905141 1.39E-06 0.000117189 RAPGEF2 ENSG00000109756 4576.63986 0.81122573 1.45E-06 0.00012136 GNAO1 ENSG00000087258 483.4867121 -1.287431863 1.45E-06 0.00012136 HBP1 ENSG00000105856 6890.256591 0.94378736 1.45E-06 0.00012136 UPP1 ENSG00000183696 14183.1007 1.139463653 1.47E-06 0.000122274 C11orf68 ENSG00000175573 2047.563979 -0.916162368 1.50E-06 0.000123639 CDKN1A ENSG00000124762 8972.260202 1.551540974 1.53E-06 0.000125983 PEX11A ENSG00000166821 148.969269 -1.34080317 1.55E-06 0.000127158 F2R ENSG00000181104 2979.005197 -1.419303531 1.58E-06 0.00012924 GZMA ENSG00000145649 8458.023286 -1.422763693 1.60E-06 0.000130446 INPP5E ENSG00000148384 2810.628488 -0.735569839 1.61E-06 0.000130978 RAB39A ENSG00000179331 243.9393998 1.192008756 1.70E-06 0.000136625 ETS2 ENSG00000157557 12212.97833 1.494785816 1.71E-06 0.000136992

UBIAD1 ENSG00000120942 2116.544913 -0.564414785 1.79E-06 0.000142577 LBH ENSG00000213626 11105.86233 -1.323269589 1.83E-06 0.000144922 MET ENSG00000105976 136.1113017 -2.159610012 1.95E-06 0.000153235 SETD7 ENSG00000145391 4068.898066 0.736482702 1.94E-06 0.000153235 TOP3B ENSG00000100038 2717.190096 -0.562899578 1.96E-06 0.000153559 ANKRD27 ENSG00000105186 2135.023911 0.686562866 1.99E-06 0.000154952 MANEAL ENSG00000185090 109.1904447 -1.261920739 2.04E-06 0.000158325 ARHGEF19 ENSG00000142632 1084.573682 -0.797154018 2.07E-06 0.000159504 IGFBP3 ENSG00000146674 563.4296607 -1.561733546 2.08E-06 0.000159533 SLC9A9 ENSG00000181804 2594.820263 0.614246078 2.46E-06 0.000181146 KIFC3 ENSG00000140859 1013.383013 -1.199234445 2.49E-06 0.000182226 PDGFD ENSG00000170962 889.1244517 -1.4910466 2.50E-06 0.000183127 LGALS3 ENSG00000131981 13129.40266 1.076108849 2.57E-06 0.000186648 RNASE2 ENSG00000169385 3722.338638 1.44777573 2.58E-06 0.000187264 LRRC32 ENSG00000137507 58.09778899 1.44856353 2.65E-06 0.000190844 STRAP ENSG00000023734 6484.750311 0.591491661 2.79E-06 0.000198629 SYTL1 ENSG00000142765 10621.43473 -0.802366458 2.94E-06 0.000207564 LPCAT4 ENSG00000176454 3023.308558 -0.696096818 2.99E-06 0.000210159 DCTN4 ENSG00000132912 5705.520597 0.971798484 3.09E-06 0.000215975 LONRF1 ENSG00000154359 2515.274649 0.835709313 3.10E-06 0.000215975 SLC11A2 ENSG00000110911 3913.004471 0.772305341 3.09E-06 0.000215975 ACD ENSG00000102977 1387.67798 -0.767489178 3.10E-06 0.000215975 LLGL1 ENSG00000131899 2493.491099 -0.759410508 3.29E-06 0.000224225 MVK ENSG00000110921 729.2162904 -0.833435462 3.27E-06 0.000224225 ALB ENSG00000163631 39.00400978 2.389748514 3.28E-06 0.000224225 APOBEC3H ENSG00000100298 443.0572146 -1.040469224 3.31E-06 0.000224649 DXO ENSG00000204348 1206.37801 -0.601437329 3.41E-06 0.000229592 VCAN ENSG00000038427 77867.70497 0.975531646 3.50E-06 0.000234812 CDKN2A ENSG00000147889 197.1440871 -0.7573203 3.62E-06 0.000240523 ITPRIPL1 ENSG00000198885 912.7110681 -1.207836419 3.62E-06 0.000240523 IRF2BP1 ENSG00000170604 1781.343416 -0.950867329 3.64E-06 0.000240987 CUL3 ENSG00000036257 7557.95976 0.563238648 3.77E-06 0.00024711 CCM2 ENSG00000136280 8951.439461 -0.584443115 3.88E-06 0.000253046 MSC ENSG00000178860 232.4995451 -1.104124514 4.09E-06 0.000263154 KLRD1 ENSG00000134539 7296.500843 -1.342702186 4.08E-06 0.000263154 CEP250 ENSG00000126001 5754.956951 -0.927479441 4.14E-06 0.000265862 PERP ENSG00000112378 381.3268088 -1.141855083 4.17E-06 0.000266987 HDHD3 ENSG00000119431 827.7949249 -0.883792103 4.18E-06 0.000266987 NUFIP2 ENSG00000108256 14966.8364 0.874793404 4.60E-06 0.000287894 KBTBD11 ENSG00000176595 2574.175121 0.966132471 4.64E-06 0.000289221 XYLT2 ENSG00000015532 2764.056499 -0.597217462 4.88E-06 0.000300171 U2AF1 ENSG00000160201 9247.116371 0.831352675 4.98E-06 0.000304391 KLHL15 ENSG00000174010 2095.27875 1.299384223 5.04E-06 0.000307023 CHST12 ENSG00000136213 3306.675058 -1.127499722 5.32E-06 0.000322405 SOCS3 ENSG00000184557 12336.89326 1.602926082 5.35E-06 0.000322496 CBX6 ENSG00000183741 6284.329909 0.750748614 5.36E-06 0.000322496

ANKZF1 ENSG00000163516 6576.369433 -0.398532558 5.57E-06 0.000330773 ABCC10 ENSG00000124574 3183.656776 -0.623262385 5.61E-06 0.0003324 MARCH9 ENSG00000139266 2835.872735 -0.968693446 5.63E-06 0.00033254 CPTP ENSG00000224051 1312.724948 -0.937295892 5.78E-06 0.000337727 C19orf44 ENSG00000105072 367.0587207 -0.735809625 5.77E-06 0.000337727 APEX2 ENSG00000169188 1021.781837 -1.102030442 5.81E-06 0.000337969 MAP3K1 ENSG00000095015 22456.5347 0.775751797 5.86E-06 0.000340362 S100A12 ENSG00000163221 16378.7987 1.28216556 6.08E-06 0.000349891 SPTLC1 ENSG00000090054 3786.056768 0.542360721 6.15E-06 0.000353075 KIF19 ENSG00000196169 428.5814574 -1.414212322 6.16E-06 0.000353192 NDUFAF5 ENSG00000101247 1237.168747 0.78684838 6.27E-06 0.000356791 CLEC7A ENSG00000172243 16604.38881 1.24579507 6.42E-06 0.000363189 MUM1 ENSG00000160953 2168.172625 -0.523768125 6.41E-06 0.000363189 JAKMIP2 ENSG00000176049 638.2090258 -1.428486977 6.56E-06 0.000369217 CACNA2D2 ENSG00000007402 1737.134594 -1.34776894 6.60E-06 0.000370914 USP6NL ENSG00000148429 2583.023557 0.845424897 6.79E-06 0.000378737 LGALS9C ENSG00000171916 297.2250545 -1.214380353 6.80E-06 0.000378866 GFI1 ENSG00000162676 1996.413313 -1.276026162 6.90E-06 0.000382906 RPRD1A ENSG00000141425 2606.161116 0.639098012 7.09E-06 0.000392325 STX1A ENSG00000106089 423.1938328 -1.057126348 7.40E-06 0.000408504 ABHD1 ENSG00000143994 83.66447153 -0.843572725 7.65E-06 0.000417068 KLHDC4 ENSG00000104731 4599.876482 -0.526855064 7.63E-06 0.000417068 ARVCF ENSG00000099889 531.4521484 -1.215103168 7.71E-06 0.0004187 DIAPH2 ENSG00000147202 2994.006242 0.781146721 7.71E-06 0.0004187 PPARG ENSG00000132170 164.0586126 1.615357042 7.77E-06 0.000421202 IFNGR1 ENSG00000027697 19796.87821 1.078116095 7.80E-06 0.000421531 RAB3GAP1 ENSG00000115839 4028.254548 0.595084138 8.03E-06 0.000431544 SFPQ ENSG00000116560 28270.28764 0.879967054 8.15E-06 0.000437268 MAPK6 ENSG00000069956 3308.058834 0.936742365 8.26E-06 0.00044089 CYBB ENSG00000165168 91940.34908 0.951955142 8.25E-06 0.00044089 C1QB ENSG00000173369 713.1319271 1.507874106 8.30E-06 0.000442471 MIS18A ENSG00000159055 389.1360578 -0.70470667 8.34E-06 0.000443799 GRB10 ENSG00000106070 1036.776433 0.859843084 8.53E-06 0.000451148 SLC23A1 ENSG00000170482 677.9827119 0.848626255 8.67E-06 0.000457303 RSG1 ENSG00000132881 166.7584069 -1.018108056 8.83E-06 0.000464799 ZFP37 ENSG00000136866 150.9418841 -1.310142433 8.94E-06 0.000468127 GNB4 ENSG00000114450 4857.987468 0.781260948 8.96E-06 0.000468127 WASL ENSG00000106299 1143.580394 1.005803351 8.96E-06 0.000468127 DRAM1 ENSG00000136048 975.506749 1.065049241 8.92E-06 0.000468127 RTKN ENSG00000114993 88.89663754 -1.136427779 9.01E-06 0.000469643 CNTLN ENSG00000044459 773.7403123 0.9435165 9.43E-06 0.000488724 ACKR3 ENSG00000144476 247.9406057 -1.195339317 9.47E-06 0.000489759 PLIN1 ENSG00000166819 31.56010243 -1.42923166 9.62E-06 0.000495624 CTC-529I10.2 ENSG00000227782 173.2743415 1.156343784 9.67E-06 0.000496157 RBM38 ENSG00000132819 11708.88926 1.588956288 9.98E-06 0.000506037 SLC1A7 ENSG00000162383 603.1821368 -1.778047229 9.96E-06 0.000506037

CENPQ ENSG00000031691 297.0167874 -0.903372372 1.04E-05 0.000519632 EDC3 ENSG00000179151 2054.651701 -0.635220635 1.03E-05 0.000519632 RP1-122P22.4 ENSG00000268628 22.03761756 1.920411607 1.05E-05 0.000524016 VRK2 ENSG00000028116 3193.90222 0.666764071 1.05E-05 0.000525471 FBXO48 ENSG00000204923 487.2402045 -0.793477485 1.06E-05 0.000525911 ZFYVE28 ENSG00000159733 2979.779613 -1.022246754 1.06E-05 0.000525911 KLHL2 ENSG00000109466 4609.742881 1.020292896 1.08E-05 0.000532993 FGD4 ENSG00000139132 4083.789304 1.239632857 1.08E-05 0.000532993 GCNT2 ENSG00000111846 1196.941849 0.977861141 1.08E-05 0.000532993 TMEM99 ENSG00000167920 126.3964465 -1.293345818 1.08E-05 0.000532993 MED11 ENSG00000161920 1059.675577 -0.748647177 1.12E-05 0.000547892 PDCD7 ENSG00000090470 2090.420368 -0.667090072 1.14E-05 0.000554399 ANKRD13B ENSG00000198720 203.1784729 -1.080515465 1.14E-05 0.000555873 RAB34 ENSG00000109113 1721.117543 0.847691185 1.15E-05 0.000557206 RTN4R ENSG00000040608 89.40759065 -1.513085146 1.15E-05 0.000558489 RASGEF1B ENSG00000138670 2449.619572 1.093622555 1.19E-05 0.000572081 ATXN7L2 ENSG00000162650 902.1127976 -0.700047846 1.20E-05 0.000573638 DDX23 ENSG00000174243 8215.318547 -0.457189893 1.20E-05 0.000573638 WASF1 ENSG00000112290 319.3644618 1.046107711 1.20E-05 0.00057385 ARID5A ENSG00000196843 4681.582572 0.888958395 1.22E-05 0.000577383 CDAN1 ENSG00000140326 1866.384898 -0.440469923 1.21E-05 0.000577383 COPS7B ENSG00000144524 3672.373251 -0.404060001 1.23E-05 0.000584286 H2AFY ENSG00000113648 25182.96543 0.665673549 1.30E-05 0.000610687 PTGER3 ENSG00000050628 446.4707322 2.046420568 1.30E-05 0.000612658 APLP2 ENSG00000084234 72809.60056 0.891778898 1.34E-05 0.000628271 CMKLR1 ENSG00000174600 2304.900183 -1.223999162 1.36E-05 0.000632692 OSER1 ENSG00000132823 8652.848949 0.705946611 1.36E-05 0.000634578 SEC24B ENSG00000138802 5289.46348 0.716736166 1.36E-05 0.000634578 DOK4 ENSG00000125170 151.8741351 -1.121279349 1.39E-05 0.000642962 PDGFRB ENSG00000113721 1194.545184 -1.367784319 1.39E-05 0.000642962 PRSS57 ENSG00000185198 131.3998129 -1.598312357 1.40E-05 0.000645398 BTG3 ENSG00000154640 1022.732084 0.904557364 1.42E-05 0.000652 TTC38 ENSG00000075234 4687.2353 -1.228329652 1.45E-05 0.000662896 SMCO4 ENSG00000166002 1950.204754 1.058239595 1.48E-05 0.000674698 GADD45B ENSG00000099860 5834.152143 1.072581669 1.52E-05 0.000689321 AGFG2 ENSG00000106351 1169.445594 -1.218102515 1.53E-05 0.000693581 DSC2 ENSG00000134755 1939.271063 1.461078295 1.53E-05 0.000693581 DLEC1 ENSG00000008226 636.1755678 -0.87368807 1.56E-05 0.000699642 RLF ENSG00000117000 5908.152545 0.752359087 1.56E-05 0.000699642 KIAA1958 ENSG00000165185 928.2402325 1.031052877 1.58E-05 0.000709234 CAPN12 ENSG00000182472 430.9168373 -0.845293677 1.59E-05 0.00071167 CERS4 ENSG00000090661 1399.379823 -0.732958416 1.68E-05 0.000746791 JAKMIP1 ENSG00000152969 1559.504858 -1.256842969 1.78E-05 0.000781124 MCTP1 ENSG00000175471 4718.597448 0.75824243 1.82E-05 0.000795465 IL17C ENSG00000124391 46.57338872 -1.44375119 1.86E-05 0.000802473 MEF2A ENSG00000068305 7409.714369 1.020307987 1.86E-05 0.000802473

ARHGAP10 ENSG00000071205 1128.120053 -0.816291865 1.86E-05 0.000802473 ATP2B4 ENSG00000058668 15873.64258 -0.955688087 1.91E-05 0.000820772 BCS1L ENSG00000074582 1133.436821 -0.702956257 1.93E-05 0.00082938 FAM131B ENSG00000159784 286.4971189 -1.198081184 1.98E-05 0.000843027 EVI5 ENSG00000067208 2141.972857 0.821908843 2.02E-05 0.000857553 ADGRB2 ENSG00000121753 209.6422416 -1.250327318 2.03E-05 0.000858325 SCUBE3 ENSG00000146197 129.7630244 -1.373728244 2.04E-05 0.000860743 PPP1R16A ENSG00000160972 912.5968439 -0.772797866 2.08E-05 0.000874883 COL6A2 ENSG00000142173 5155.304836 -1.315156603 2.13E-05 0.000894728 DAXX ENSG00000204209 4657.334419 -0.733303146 2.16E-05 0.000904026 XPC ENSG00000154767 5375.543305 -0.490827417 2.16E-05 0.000905704 FAM220A ENSG00000178397 857.565949 -0.587537492 2.18E-05 0.000910848 CC2D1B ENSG00000154222 5177.875394 -0.4684603 2.19E-05 0.000912456 CAMK2N1 ENSG00000162545 195.0687712 -1.388479646 2.23E-05 0.00092326 AARS2 ENSG00000124608 1580.943746 -0.603178846 2.30E-05 0.000942495 CLCN5 ENSG00000171365 1710.422255 0.905599039 2.29E-05 0.000942495 S100A8 ENSG00000143546 95404.69274 1.260162113 2.35E-05 0.000962499 GPR153 ENSG00000158292 430.0227734 -1.225075288 2.35E-05 0.000962499 SOWAHC ENSG00000198142 367.3555269 0.995106317 2.38E-05 0.000969295 SCPEP1 ENSG00000121064 14674.2618 0.865715956 2.41E-05 0.000980694 RRAGB ENSG00000083750 1318.468069 0.533108729 2.42E-05 0.00098305 STX11 ENSG00000135604 16436.65911 0.934120051 2.46E-05 0.00099795 FAM198B ENSG00000164125 8815.827199 0.994799004 2.48E-05 0.001001604 RPP25L ENSG00000164967 701.3810565 -0.963147559 2.48E-05 0.001001926 C8G ENSG00000176919 101.2520463 -0.943412947 2.54E-05 0.001023811 LCMT2 ENSG00000168806 352.6237816 -0.907779957 2.58E-05 0.00103617 ALDH1B1 ENSG00000137124 353.2044769 -0.784577134 2.70E-05 0.001079191 ZSCAN32 ENSG00000140987 1182.610241 -0.889240014 2.71E-05 0.001079411 KIAA1671 ENSG00000197077 1074.644068 -1.422033727 2.77E-05 0.001101398 PCDH1 ENSG00000156453 279.6205964 -1.546974431 2.78E-05 0.001101398 BOLA1 ENSG00000178096 320.1119689 -0.87075661 2.78E-05 0.00110251 USP21 ENSG00000143258 2293.446581 -0.499650522 2.79E-05 0.001104092 ABHD15 ENSG00000168792 3067.576579 -0.594215144 2.87E-05 0.001130983 ACTL10 ENSG00000182584 85.86222837 -1.485940934 2.89E-05 0.001133536 CARMIL3 ENSG00000186648 883.2661081 -1.216646317 2.89E-05 0.001133536 PLK3 ENSG00000173846 6138.288864 1.267880779 2.92E-05 0.001137157 ARHGAP24 ENSG00000138639 1953.123161 1.153760644 2.91E-05 0.001137157 NINL ENSG00000101004 787.7576062 -1.582951198 2.93E-05 0.001140521 RARG ENSG00000172819 1219.11898 -0.560906471 2.94E-05 0.001140521 FANCG ENSG00000221829 998.8246489 -0.619680071 2.97E-05 0.001149063 IRAK3 ENSG00000090376 11336.32157 1.419104615 2.99E-05 0.001152447 RPL39L ENSG00000163923 175.5108336 -1.132969343 3.00E-05 0.00115438 AHDC1 ENSG00000126705 1743.68102 -0.686507448 3.07E-05 0.001181645 MARCH1 ENSG00000145416 7278.974738 0.986974765 3.13E-05 0.001199767 KLRF1 ENSG00000150045 4429.182379 -1.376345233 3.18E-05 0.00121122 ZNF837 ENSG00000152475 149.8458269 -1.100558493 3.21E-05 0.001219984

OGFOD1 ENSG00000087263 1808.140198 -0.569747531 3.28E-05 0.001242323 UBASH3B ENSG00000154127 3679.697443 0.623618372 3.35E-05 0.001267164 RP3-461P17.10 ENSG00000269549 140.5595837 -0.957697005 3.38E-05 0.001274839 GALNT5 ENSG00000136542 26.74073831 2.051953646 3.40E-05 0.001279406 AFAP1L2 ENSG00000169129 233.762387 -0.917953885 3.41E-05 0.001282272 RNF144B ENSG00000137393 12885.15874 1.326336311 3.55E-05 0.001323863 DCP1B ENSG00000151065 1559.401233 -0.644074908 3.57E-05 0.001328146 GNA13 ENSG00000120063 19332.64285 0.626243305 3.61E-05 0.001343797 ZNF792 ENSG00000180884 953.8553526 -0.718374942 3.70E-05 0.001371706 TSPOAP1 ENSG00000005379 5721.92413 -1.003092913 3.73E-05 0.001380504 RAB12 ENSG00000206418 7151.102591 0.818678083 3.73E-05 0.001380504 OLFM2 ENSG00000105088 171.7733022 -1.265344863 3.74E-05 0.001381373 IGFBP2 ENSG00000115457 85.24682574 2.162215391 3.83E-05 0.001400946 PROB1 ENSG00000228672 155.1753593 -1.05852169 3.89E-05 0.001423057 SUMO3 ENSG00000184900 8121.126946 0.605544383 3.97E-05 0.001443774 RAPH1 ENSG00000173166 99.27508735 1.004618286 4.02E-05 0.001452861 TBC1D17 ENSG00000104946 4786.704247 -0.582191495 4.03E-05 0.001453302 SIX5 ENSG00000177045 82.85331522 -1.571216493 4.08E-05 0.001470003 PROS1 ENSG00000184500 239.8691145 1.262935296 4.11E-05 0.001473008 OSBPL7 ENSG00000006025 4116.834693 -0.681093127 4.13E-05 0.001478169 ZNF181 ENSG00000197841 738.84716 -0.788167886 4.18E-05 0.001485967 TNFRSF12A ENSG00000006327 307.4806264 1.406755686 4.17E-05 0.001485967 LAX1 ENSG00000122188 1477.514416 -1.217216674 4.20E-05 0.001490326 ABCA3 ENSG00000167972 834.3529628 -0.861798215 4.27E-05 0.001513199 FGD6 ENSG00000180263 1607.829823 1.007538194 4.28E-05 0.001514633 ZNF501 ENSG00000186446 103.3572915 -1.138251611 4.33E-05 0.001523162 VIT ENSG00000205221 67.89043635 -1.960853855 4.36E-05 0.001532614 KLRB1 ENSG00000111796 7759.409894 -1.121242697 4.37E-05 0.001534311 RUSC1 ENSG00000160753 1435.710334 -0.490974928 4.45E-05 0.001553361 DOLK ENSG00000175283 322.977296 -0.726432575 4.46E-05 0.001557192 NTSR1 ENSG00000101188 683.2222961 1.450475183 4.53E-05 0.00157475 APP ENSG00000142192 12500.7003 0.640233107 4.62E-05 0.001602137 PIGA ENSG00000165195 2795.272991 0.749930904 4.65E-05 0.001610803 SERPINH1 ENSG00000149257 464.0821682 -0.635385494 4.70E-05 0.001622871 STOML1 ENSG00000067221 523.3614554 -0.837506351 4.69E-05 0.001622871 PTCH1 ENSG00000185920 1925.065534 -1.112976079 4.71E-05 0.001624376 P3H4 ENSG00000141696 261.2977454 -1.182155151 4.71E-05 0.001624376 COPS2 ENSG00000166200 5631.846296 0.682144722 4.76E-05 0.001638605 FZD7 ENSG00000155760 38.26556657 -1.635503889 4.77E-05 0.001639791 ZNF365 ENSG00000138311 327.9390724 -1.231317557 4.78E-05 0.001639791 PARD6A ENSG00000102981 231.8337995 -0.859223439 4.86E-05 0.001660671 FCGR1B ENSG00000198019 725.9476153 1.338672835 4.89E-05 0.001663263 FUT2 ENSG00000176920 63.73241892 -1.119170212 4.89E-05 0.001663263 LYAR ENSG00000145220 3519.937626 -0.623747446 4.89E-05 0.001663263 SNX2 ENSG00000205302 10770.20019 0.584738666 4.98E-05 0.001687896 GNS ENSG00000135677 26738.30201 0.736993485 4.98E-05 0.001687896

GIPC1 ENSG00000123159 1898.486317 -0.96954683 5.03E-05 0.001691571 RAB11FIP3 ENSG00000090565 3559.412923 -0.650073849 5.11E-05 0.001711832 LIN7A ENSG00000111052 2057.006915 0.933192438 5.15E-05 0.001720538 KCTD3 ENSG00000136636 581.9468917 0.679767399 5.39E-05 0.00178733 TMTC2 ENSG00000179104 1799.321706 0.750619755 5.47E-05 0.001807667 HCN3 ENSG00000143630 243.922921 -0.82057242 5.47E-05 0.001807667 H1F0 ENSG00000189060 3765.797656 1.2065652 5.58E-05 0.001833745 FAM20A ENSG00000108950 334.6261029 1.711151703 5.59E-05 0.001834213 FCGR1A ENSG00000150337 3093.651416 1.282655685 5.62E-05 0.001839843 PDE4B ENSG00000184588 8188.153853 0.881977788 5.64E-05 0.001841463 KYNU ENSG00000115919 4371.172588 1.048112989 5.69E-05 0.001853495 LYN ENSG00000254087 27286.21217 0.730989502 5.72E-05 0.001861522 SCD5 ENSG00000145284 291.1507005 -1.355203139 5.77E-05 0.001871319 CTSA ENSG00000064601 18711.01707 0.77858478 5.81E-05 0.001875854 ACOT4 ENSG00000177465 153.6767489 -1.206378453 5.86E-05 0.001881852 PSTPIP2 ENSG00000152229 8179.52043 0.872323575 5.86E-05 0.001881852 ARSB ENSG00000113273 2878.970649 0.704214951 5.87E-05 0.001881852 EFNA5 ENSG00000184349 77.3532942 -1.68700624 5.96E-05 0.001902471 RIT1 ENSG00000143622 5070.415684 0.945916195 5.98E-05 0.00190331 RDH12 ENSG00000139988 19.91573024 1.393840387 6.00E-05 0.001905127 RAP1GAP ENSG00000076864 189.7683174 2.089664319 6.00E-05 0.00190518 SAMSN1 ENSG00000155307 10714.97382 1.283071222 6.03E-05 0.001906893 RPUSD3 ENSG00000156990 2165.469124 -0.511927078 6.10E-05 0.001921146 IFNGR2 ENSG00000159128 14262.79927 0.794178981 6.23E-05 0.001956157 GIMAP6 ENSG00000133561 8479.13976 -0.870515122 6.24E-05 0.001959104 ZNF853 ENSG00000236609 560.2201026 -1.09702136 6.27E-05 0.001964418 ANGPTL6 ENSG00000130812 216.342045 -1.372365773 6.28E-05 0.001965175 NCOA3 ENSG00000124151 8743.305336 0.672783001 6.31E-05 0.001966381 GAREM2 ENSG00000157833 152.8762904 -0.866529849 6.39E-05 0.001985876 C5orf66 ENSG00000224186 101.7825297 1.039960855 6.45E-05 0.001994883 MKRN1 ENSG00000133606 16245.54815 0.589098199 6.49E-05 0.002005514 CADM1 ENSG00000182985 488.7834504 -1.248792804 6.54E-05 0.002019405 UBE2R2 ENSG00000107341 11300.87774 0.71357963 6.65E-05 0.002050107 UBE2D3 ENSG00000109332 30977.78058 0.438324714 6.73E-05 0.002072059 PDS5B ENSG00000083642 3193.076957 0.63062841 6.74E-05 0.002072059 INPP5A ENSG00000068383 1775.854984 0.592743087 6.75E-05 0.002074208 CCDC88A ENSG00000115355 6081.737384 0.744708343 6.77E-05 0.002075746 NNMT ENSG00000166741 22.87393808 2.069314241 6.79E-05 0.002080965 DRAXIN ENSG00000162490 374.1818066 -1.365586872 6.85E-05 0.002096352 SLX4 ENSG00000188827 2071.635874 -0.501945125 6.87E-05 0.002101399 TUBE1 ENSG00000074935 991.1104266 -0.790304104 6.99E-05 0.002125633 C19orf73 ENSG00000221916 37.44493375 -1.313853573 7.08E-05 0.002148147 ERLIN2 ENSG00000147475 2795.177167 0.499939801 7.11E-05 0.002155899 UNG ENSG00000076248 938.7355263 -0.769851179 7.13E-05 0.002158577 USP32 ENSG00000170832 7269.675688 0.728869958 7.14E-05 0.002159428 KIF1BP ENSG00000198954 709.235369 -0.603148015 7.16E-05 0.002162327

CAPNS1 ENSG00000126247 22108.20862 0.777798327 7.21E-05 0.002165646 GPR171 ENSG00000174946 1210.591066 -1.158376833 7.23E-05 0.002170727 CCSER1 ENSG00000184305 99.42267705 1.095911465 7.26E-05 0.002173921 JDP2 ENSG00000140044 5811.011124 1.395672067 7.26E-05 0.002173921 PTPRM ENSG00000173482 953.843155 -1.130183664 7.32E-05 0.002188068 ADIPOR1 ENSG00000159346 17474.2034 0.988195192 7.39E-05 0.002200958 PRF1 ENSG00000180644 10954.26315 -1.058360889 7.40E-05 0.002200958 CHTF18 ENSG00000127586 1450.410563 -0.681539931 7.49E-05 0.002221616 ASB6 ENSG00000148331 3755.040318 -0.464413761 7.61E-05 0.00224865 RBM47 ENSG00000163694 5217.322144 0.840865532 7.63E-05 0.002251461 LZTS2 ENSG00000107816 1981.964553 -0.576496328 7.71E-05 0.002269771 CD2 ENSG00000116824 10793.34049 -0.993141169 7.87E-05 0.002311654 UBE2E1 ENSG00000170142 7397.232784 0.575312274 8.08E-05 0.002364074 AMZ1 ENSG00000174945 317.5011624 1.461200467 8.15E-05 0.002380589 COL1A1 ENSG00000108821 40.23680299 2.00597243 8.34E-05 0.002427323 SGCB ENSG00000163069 419.6260118 -0.635872576 8.34E-05 0.002427323 LRFN2 ENSG00000156564 55.48527018 -1.967659768 8.38E-05 0.002433189 TLR3 ENSG00000164342 136.2626764 -1.363362344 8.39E-05 0.002433189 ALAS1 ENSG00000023330 3583.997305 0.769706499 8.49E-05 0.002451409 DUSP4 ENSG00000120875 537.9841965 1.340535736 8.51E-05 0.002454966 CHD1 ENSG00000153922 12973.35325 0.811162764 8.55E-05 0.002459881 MKKS ENSG00000125863 1833.989807 -0.741549892 8.69E-05 0.002490209 COQ6 ENSG00000119723 1378.562665 -0.407828306 8.81E-05 0.002514306 S100A9 ENSG00000163220 305570.2787 1.140830586 8.82E-05 0.002515435 FRMD8 ENSG00000126391 3468.052415 -0.648289481 8.93E-05 0.002542858 YBX3 ENSG00000060138 8350.847072 1.161712207 9.03E-05 0.002570835 COTL1 ENSG00000103187 90140.78917 0.771849707 9.07E-05 0.002576682 ADM ENSG00000148926 2084.071823 1.468348293 9.23E-05 0.002606582 ACER3 ENSG00000078124 2765.959259 1.536691868 9.23E-05 0.002606582 TMEM81 ENSG00000174529 208.7790862 -0.710275612 9.42E-05 0.00265447 MATN1 ENSG00000162510 95.47449949 1.379107943 9.45E-05 0.002657548 MICU1 ENSG00000107745 5606.525015 0.700619156 9.47E-05 0.002660823 NUDT4 ENSG00000173598 3266.295589 0.963421964 9.52E-05 0.002671237 MMACHC ENSG00000132763 235.6427533 -0.785469641 9.61E-05 0.002682269 NMD3 ENSG00000169251 3473.144301 0.589298117 9.65E-05 0.002682269 BAG4 ENSG00000156735 1408.765994 0.819829279 9.63E-05 0.002682269 IFNG ENSG00000111537 537.7014124 -1.345829653 9.60E-05 0.002682269 POMGNT1 ENSG00000085998 2511.903886 -0.548585099 9.59E-05 0.002682269 SSFA2 ENSG00000138434 6783.747846 0.638409534 9.70E-05 0.002689915 PTPN7 ENSG00000143851 5552.732298 -0.679596471 9.72E-05 0.002692093 MYO6 ENSG00000196586 727.9160717 -1.239421029 9.76E-05 0.002695404 NFKB1 ENSG00000109320 8636.639318 0.53394703 9.95E-05 0.002735988 CLCN2 ENSG00000114859 375.8837391 -0.564672678 0.000100295 0.00274584 SLC29A2 ENSG00000174669 608.0616495 -0.968875609 0.000100181 0.00274584 CCNY ENSG00000108100 13936.64409 0.527729403 0.000102217 0.002789626 ZNF584 ENSG00000171574 237.0199419 -0.821758988 0.000103327 0.002813418

MKS1 ENSG00000011143 630.5895663 -0.631270712 0.000104664 0.002841466 FAM173A ENSG00000103254 636.5512268 -0.774814863 0.000105294 0.002855604 YBX1 ENSG00000065978 47656.74977 0.522244148 0.000106541 0.002880372 C11orf45 ENSG00000174370 71.64357352 -1.139080318 0.000108554 0.002922614 VIPR2 ENSG00000106018 72.37177892 -1.641767249 0.000109689 0.002947078 GIN1 ENSG00000145723 478.1509176 -0.862131509 0.000109961 0.002948294 ECHDC3 ENSG00000134463 922.0209156 1.513558709 0.000110114 0.002948294 CBX3 ENSG00000122565 5652.661112 0.472695679 0.000110618 0.002953679 NCALD ENSG00000104490 1425.479873 -1.215805482 0.000114519 0.003048439 FAM46A ENSG00000112773 4936.548218 0.877773316 0.000114738 0.003051135 TTC30B ENSG00000196659 149.7956851 -0.91640925 0.000114974 0.003054291 SMURF1 ENSG00000198742 3728.445037 0.690982874 0.000115796 0.003072965 KRBOX4 ENSG00000147121 1162.354816 -0.679206327 0.000117526 0.003107515 ZBTB12 ENSG00000204366 105.0252369 -0.91792968 0.000118104 0.003111949 LRIF1 ENSG00000121931 819.7222712 -0.752690242 0.000117891 0.003111949 DHX57 ENSG00000163214 3037.763023 0.546245762 0.000118032 0.003111949 ST8SIA4 ENSG00000113532 6556.931365 0.667082377 0.000119778 0.003152862 SNTB1 ENSG00000172164 4180.749914 0.685195701 0.000121015 0.003173775 UBE2I ENSG00000103275 7289.502327 0.458394978 0.000123169 0.003212195 PRKACA ENSG00000072062 12679.34298 0.587636311 0.000123305 0.003212195 PGBD2 ENSG00000185220 638.5821039 -1.034162462 0.00012309 0.003212195 DIP2B ENSG00000066084 5665.670911 0.606216671 0.000123812 0.003218924 PLEKHB2 ENSG00000115762 5659.234921 0.931107643 0.000124503 0.003224894 CHPF ENSG00000123989 448.9046474 -1.083708982 0.000125935 0.003252259 LRCH1 ENSG00000136141 2912.575398 0.550258969 0.000126137 0.003254232 IKZF3 ENSG00000161405 11791.68904 -1.265576603 0.000127164 0.003269102 ZNF823 ENSG00000197933 240.7224965 -0.923948903 0.000127217 0.003269102 RNF175 ENSG00000145428 899.4318963 1.016551889 0.000127754 0.003277072 MAP3K10 ENSG00000130758 1652.504887 -0.667216263 0.00012778 0.003277072 TNS3 ENSG00000136205 4199.776377 0.656255337 0.000127923 0.003277501 TMEM223 ENSG00000168569 692.0168847 -0.58989889 0.000128069 0.003278007 BTBD17 ENSG00000204347 16.72300949 -2.020395286 0.00012827 0.003279912 ZNF124 ENSG00000196418 685.713089 0.711717869 0.00012959 0.003288551 RPA2 ENSG00000117748 4273.467321 -0.518691239 0.000129428 0.003288551 CNNM3 ENSG00000168763 4224.391615 -0.672162493 0.000129115 0.003288551 C1orf74 ENSG00000162757 892.3583307 -1.177285131 0.000129609 0.003288551 TET3 ENSG00000187605 10797.68382 0.844434659 0.000130014 0.003288879 CEP170 ENSG00000143702 4144.917894 0.828170576 0.000130404 0.003295533 PSPN ENSG00000125650 177.6939756 -0.809355978 0.000131296 0.00331484 LOXL3 ENSG00000115318 1674.585415 0.688179994 0.000133003 0.003348175 KLHL4 ENSG00000102271 22.92595423 -2.003632223 0.000134018 0.003367089 CSGALNACT2 ENSG00000169826 20811.65658 0.94098045 0.000134117 0.003367089 RNASEH2C ENSG00000172922 3577.510125 -0.462575636 0.000134144 0.003367089 KLC2 ENSG00000174996 1926.681513 -0.602185244 0.000134408 0.00337046 XCL1 ENSG00000143184 243.5988265 -1.364101381 0.000135019 0.003373219 CUL5 ENSG00000166266 2620.575201 0.750059978 0.000135038 0.003373219

EPSTI1 ENSG00000133106 8827.648413 1.010340867 0.000134995 0.003373219 MYL9 ENSG00000101335 1641.152645 1.53571583 0.000135448 0.003378618 ARG1 ENSG00000118520 862.5045368 1.376427303 0.000135514 0.003378618 SPATA6 ENSG00000132122 914.9952578 0.822305511 0.000136831 0.003404908 LARP4B ENSG00000107929 8539.168278 0.385993289 0.000137549 0.003419501 NID2 ENSG00000087303 148.651023 -1.278021874 0.000138873 0.0034425 NETO1 ENSG00000166342 62.68640423 1.298231396 0.000139763 0.003461279 INSR ENSG00000171105 2288.448022 1.012494114 0.000140671 0.00348044 MUTYH ENSG00000132781 1352.182895 -0.49005962 0.000141818 0.003502129 SH2B1 ENSG00000178188 6691.925551 -0.372129517 0.000141993 0.003503126 DHRS13 ENSG00000167536 820.224329 -0.605381547 0.00014478 0.003554989 GTF2B ENSG00000137947 3158.834946 0.621113566 0.000146893 0.003593267 FCGR1CP ENSG00000265531 745.6151726 1.494181754 0.000147241 0.003595007 AGTPBP1 ENSG00000135049 15111.44314 0.692126792 0.000148195 0.003614911 P2RX4 ENSG00000135124 4104.025249 0.62826996 0.000148595 0.003617854 TSEN54 ENSG00000182173 4013.140134 -0.91256893 0.000149854 0.003641685 HSBP1L1 ENSG00000226742 1023.685411 0.782771912 0.000155619 0.003760652 GUCY2C ENSG00000070019 621.6445549 0.869793764 0.00015722 0.003785239 TIMM17A ENSG00000134375 4383.882996 0.610771619 0.000157141 0.003785239 CFL2 ENSG00000165410 1090.535203 0.73244272 0.000158995 0.003817893 F5 ENSG00000198734 5474.243076 0.93250602 0.000159165 0.003817893 MMD ENSG00000108960 2197.77707 1.00664309 0.000159708 0.003824245 GCSAM ENSG00000174500 854.6115092 -1.126494886 0.000161918 0.003856724 RP11-80A15.1 ENSG00000258744 83.61497585 -0.891578568 0.000161972 0.003856724 QSER1 ENSG00000060749 2287.751621 0.643154365 0.000162143 0.003857241 SP3 ENSG00000172845 11488.0693 0.669812533 0.000162913 0.003864942 ZAP70 ENSG00000115085 25001.34114 -0.875491105 0.000164412 0.00389693 SH2D2A ENSG00000027869 4608.633139 -1.131319759 0.000165417 0.003914846 IL13RA1 ENSG00000131724 11257.95348 0.859039548 0.000166487 0.003921046 BNIP3L ENSG00000104765 20051.66816 1.356901737 0.000166878 0.003926708 SH3RF1 ENSG00000154447 528.3536709 0.855103689 0.000168507 0.003953978 KBTBD6 ENSG00000165572 366.7574763 -0.800803996 0.000168647 0.003953978 DNAJC28 ENSG00000177692 53.94605412 -1.314156369 0.000168299 0.003953978 PTPN2 ENSG00000175354 6933.271668 0.402605249 0.000169184 0.003958771 TEF ENSG00000167074 706.6964851 -0.717393442 0.000169309 0.003958771 PSAP ENSG00000197746 320685.9332 0.720793574 0.000170341 0.003973047 PTRH1 ENSG00000187024 246.4260735 -0.977772608 0.00017015 0.003973047 BNIP2 ENSG00000140299 10777.61629 0.638250739 0.000170531 0.003973047 ZNF691 ENSG00000164011 435.4985459 -0.879825587 0.000170787 0.003975432 WNT10A ENSG00000135925 155.9785242 -1.213843806 0.00017362 0.004034146 TWNK ENSG00000107815 589.0014288 -0.850685167 0.000176183 0.004082729 LRFN3 ENSG00000126243 442.7261359 -1.17052518 0.000178065 0.004122649 PELI2 ENSG00000139946 4924.697098 0.674303582 0.000178582 0.004130944 PDGFC ENSG00000145431 508.8961434 0.740783937 0.000179101 0.004131906 EXOC6 ENSG00000138190 1920.26995 0.744889611 0.000181054 0.004165842 EXT1 ENSG00000182197 2132.297868 0.588752968 0.000181485 0.004172068

PRMT3 ENSG00000185238 1743.680912 0.556584805 0.00018261 0.004180575 SCAF4 ENSG00000156304 7426.094043 0.595477724 0.000182742 0.004180575 VANGL1 ENSG00000173218 390.9207047 -0.924447837 0.000182578 0.004180575 PARS2 ENSG00000162396 111.847961 -1.415762975 0.000182822 0.004180575 LBX2 ENSG00000179528 74.08172582 -1.161363052 0.000183372 0.004185782 AIM1 ENSG00000112297 12221.84276 0.652839484 0.000183563 0.004186454 KLF11 ENSG00000172059 8640.296716 0.685647017 0.000185246 0.004213744 MTMR10 ENSG00000166912 5888.532324 0.62040599 0.000185951 0.00422607 UBE2T ENSG00000077152 156.9638117 -1.01169574 0.000187598 0.004252321 KDM6A ENSG00000147050 4961.732747 0.698617349 0.000189513 0.00428451 BNIP1 ENSG00000113734 885.9256065 0.580884394 0.000189758 0.004286315 SNTA1 ENSG00000101400 437.4513839 -0.931312661 0.000191582 0.004316246 WRAP53 ENSG00000141499 1032.388398 -0.469207391 0.000193773 0.004358037 ZFP64 ENSG00000020256 913.0393635 -0.607685743 0.000193974 0.004358791 IFT46 ENSG00000118096 497.571156 -0.546809566 0.000195733 0.004385943 TBL1XR1 ENSG00000177565 7350.906146 0.527546038 0.000195858 0.004385943 ZNF485 ENSG00000198298 222.778036 -0.753992142 0.000197332 0.004407539 PTS ENSG00000150787 1540.443365 0.577669837 0.000197279 0.004407539 EAF1 ENSG00000144597 1886.785741 1.013008928 0.00020076 0.004468727 GAS7 ENSG00000007237 19688.59041 0.875805935 0.00020163 0.004484235 COMTD1 ENSG00000165644 651.0852868 -0.682791671 0.00020241 0.004497721 RNF141 ENSG00000110315 7703.172068 0.573121338 0.000203675 0.004518106 ARHGEF28 ENSG00000214944 124.2409357 -1.42679873 0.000204424 0.004530855 LSS ENSG00000160285 3369.559557 -0.727184602 0.000205028 0.004540353 TRIM46 ENSG00000163462 692.1399531 -0.923967161 0.000205858 0.004547106 BTBD6 ENSG00000184887 3126.502724 -0.801270094 0.000207502 0.004571735 SYTL2 ENSG00000137501 2923.344095 -1.111829594 0.000207854 0.004575618 TMEM160 ENSG00000130748 894.82723 -0.941914234 0.000209277 0.004599777 C1orf56 ENSG00000143443 250.5650641 -0.652733425 0.000209986 0.004603574 ALPK1 ENSG00000073331 4322.383657 0.891066768 0.000210024 0.004603574 ANKMY1 ENSG00000144504 3216.828782 -0.50753915 0.000210561 0.004603574 MYO7A ENSG00000137474 1069.44376 1.234538872 0.000210433 0.004603574 MAP3K8 ENSG00000107968 5452.375662 0.649282637 0.000209807 0.004603574 SYF2 ENSG00000117614 7931.690741 0.563338467 0.000212138 0.004622855 BNIPL ENSG00000163141 118.4343069 -1.046480802 0.000212666 0.004628695 JMJD1C ENSG00000171988 14275.39307 0.913568896 0.00021725 0.004696261 OSGEPL1 ENSG00000128694 640.6226727 -0.81989291 0.000217316 0.004696261 FPR3 ENSG00000187474 274.1788497 -1.21808104 0.000217227 0.004696261 HK2 ENSG00000159399 7568.740782 0.763630823 0.000219215 0.004721589 BORCS6 ENSG00000196544 1495.05293 -0.865331618 0.000220455 0.004740429 CRELD1 ENSG00000163703 1951.782408 -0.571887203 0.000222694 0.004780646 GIMAP7 ENSG00000179144 7780.317176 -1.068620188 0.0002231 0.004781451 AZIN2 ENSG00000142920 279.5544402 -1.157801705 0.000224694 0.004799756 MTG2 ENSG00000101181 2463.97487 -0.622250073 0.000226927 0.004839483 TMEM129 ENSG00000168936 2727.038877 -0.513699549 0.000227471 0.004847122 MARS2 ENSG00000247626 683.800908 -0.608010659 0.000227911 0.0048525

RNF152 ENSG00000176641 47.60868969 1.585194377 0.000228287 0.004852549 SLC9A3R1 ENSG00000109062 12546.75135 -0.830027382 0.000228883 0.004853293 ICAM2 ENSG00000108622 4764.243833 -0.63073096 0.000228639 0.004853293 MLF1 ENSG00000178053 68.21357212 -1.092247097 0.00023046 0.004874777 CTD-2547L24.3 ENSG00000258875 516.2372492 -0.855544398 0.00023079 0.004874935 AC243756.1 ENSG00000270339 28.72545632 -1.460500594 0.000230843 0.004874935 C21orf140 ENSG00000222018 44.14456234 -0.834057052 0.000231522 0.004885295 WDR76 ENSG00000092470 741.6763223 -0.587097684 0.000232505 0.004898089 KCTD11 ENSG00000213859 785.5209951 -1.0571809 0.00023277 0.004898725 LCK ENSG00000182866 17410.37699 -0.905360883 0.000233961 0.004916782 SYNE3 ENSG00000176438 11554.11223 0.687752427 0.000235838 0.004936235 HGH1 ENSG00000235173 475.2947894 -0.816329052 0.000235682 0.004936235 QKI ENSG00000112531 5882.240194 1.107701623 0.000236094 0.004937621 HNRNPA3 ENSG00000170144 37162.12812 0.398137812 0.000237176 0.004956258 ABCG1 ENSG00000160179 2400.547608 1.191284498 0.00023768 0.004958805 PTP4A1 ENSG00000112245 8737.108359 0.580824762 0.000237521 0.004958805 RBP7 ENSG00000162444 3203.904496 0.953239883 0.000239351 0.004985646 KLHL29 ENSG00000119771 352.0675778 1.184906421 0.000239774 0.004990454 UGGT2 ENSG00000102595 543.6833907 0.805638334 0.000240365 0.004994756 PLSCR1 ENSG00000188313 8286.572242 0.916625255 0.000240383 0.004994756 SMNDC1 ENSG00000119953 3870.558003 0.536242848 0.000241981 0.005020276 GEMIN2 ENSG00000092208 346.4015165 -0.607658694 0.000243255 0.005034641 LMAN2L ENSG00000114988 660.7841741 -0.73427423 0.00024564 0.005075912 CCDC121 ENSG00000176714 69.49987096 -1.45691274 0.000246371 0.005086955 ZEB2 ENSG00000169554 27259.45811 0.839002464 0.000247684 0.005105944 SCLT1 ENSG00000151466 4578.429341 0.77918133 0.000248931 0.005127587 UNK ENSG00000132478 3394.722771 -0.533337507 0.000250772 0.005157319 CA11 ENSG00000063180 724.0006932 -0.829612497 0.000253267 0.005200379 SPHK1 ENSG00000176170 775.2255016 1.000935681 0.000254264 0.005216725 CRTAM ENSG00000109943 755.1450636 -0.948510095 0.000254535 0.005218175 IL12RB1 ENSG00000096996 3849.476019 -0.697247731 0.000257688 0.005270318 CCDC157 ENSG00000187860 298.6757043 -0.788915316 0.000258266 0.005277986 RHOQ ENSG00000119729 2711.275718 0.784731025 0.000259295 0.005290676 EPB41L4A ENSG00000129595 291.5841126 -1.451914479 0.000260786 0.005316922 ARMC5 ENSG00000140691 868.1693427 -0.775177602 0.000261679 0.005330944 NOCT ENSG00000151014 428.0397745 1.045902787 0.000263458 0.005360785 LIPM ENSG00000173239 27.21386467 1.56451009 0.000264566 0.005372879 BCL10 ENSG00000142867 2181.645053 0.6194567 0.000265594 0.005389545 STYK1 ENSG00000060140 202.6030707 -1.223552574 0.000266479 0.005403287 NSG1 ENSG00000168824 1228.849198 -0.96176748 0.000268854 0.005438691 POLH ENSG00000170734 981.5330952 -0.637429284 0.000269898 0.005451304 PLXNB1 ENSG00000164050 299.1752227 -0.683160046 0.000270238 0.005453926 UNC119B ENSG00000175970 2576.471227 -0.510605126 0.000272353 0.005488088 PPTC7 ENSG00000196850 9272.978747 0.524225225 0.000272588 0.005488565 LDOC1L ENSG00000188636 2178.566865 -0.808429226 0.000273025 0.005493088 SMAD6 ENSG00000137834 69.06749696 1.360648207 0.000273364 0.005495662

IGF2BP2 ENSG00000073792 1614.018923 1.203545267 0.000274032 0.005504828 APBB2 ENSG00000163697 151.5360851 1.365177304 0.000274649 0.00551295 SMPDL3A ENSG00000172594 1602.939428 0.990267953 0.000275519 0.005517605 ASTN2 ENSG00000148219 62.19838447 -1.227974758 0.000275731 0.005517605 PYCRL ENSG00000104524 227.5907137 -0.922136412 0.000275151 0.005517605 NT5C2 ENSG00000076685 12093.39794 0.742902396 0.00027633 0.005525313 GATA1 ENSG00000102145 459.1465182 1.735569872 0.000277367 0.005541482 KCNQ1 ENSG00000053918 5268.338235 0.764485491 0.000277662 0.005541482 MTRNR2L8 ENSG00000255823 136.0695195 1.049995153 0.000281 0.005588554 PIP5K1B ENSG00000107242 668.3542876 0.544425092 0.00028141 0.005592423 PIK3C3 ENSG00000078142 3458.044992 0.630993443 0.000282154 0.005602932 MAP4K4 ENSG00000071054 18515.84877 0.474482987 0.000282557 0.005606639 CTU1 ENSG00000142544 331.455368 -1.058307641 0.000285301 0.005639533 RSRC2 ENSG00000111011 8840.838035 0.609734913 0.000286006 0.00564486 NID1 ENSG00000116962 1871.975631 1.062601038 0.000287406 0.005659591 DVL2 ENSG00000004975 2368.756423 -0.570375294 0.000289589 0.005689614 CCDC167 ENSG00000198937 900.3648715 -0.935276161 0.000290837 0.005696891 EBF4 ENSG00000088881 414.4820433 -1.075182682 0.00029062 0.005696891 TRPC3 ENSG00000138741 56.49918961 -1.591801679 0.000296873 0.005797355 PIP4K2C ENSG00000166908 2848.037519 -0.423911217 0.000297083 0.005797355 GRINA ENSG00000178719 8951.269239 1.042040939 0.000297382 0.005798846 HEY2 ENSG00000135547 13.13565919 -1.777436552 0.000297636 0.00579943 USP15 ENSG00000135655 30520.62074 0.690984261 0.000300913 0.005845725 CHRNA7 ENSG00000175344 146.1062033 1.216132105 0.000301986 0.005862184 DTHD1 ENSG00000197057 1710.102108 -1.238656361 0.000302864 0.005874831 PPP1R1A ENSG00000135447 67.34681737 1.018959636 0.00030447 0.005897184 NSUN3 ENSG00000178694 1965.223825 0.846326495 0.000305765 0.005913425 SDC4 ENSG00000124145 333.5308161 0.7739868 0.000306978 0.005932474 ST8SIA6 ENSG00000148488 537.0890714 -1.220428523 0.000312418 0.006024138 TPRG1L ENSG00000158109 5041.034143 -0.510309602 0.00031298 0.006026017 ZNF267 ENSG00000185947 3744.137719 0.954228175 0.000317822 0.006110188 SLC16A10 ENSG00000112394 302.3739625 1.424688101 0.000321731 0.006171628 SNX13 ENSG00000071189 3309.271359 0.654134643 0.000326312 0.006226699 BCL2L12 ENSG00000126453 659.2616827 -0.682110586 0.000326521 0.006226699 SEMA6B ENSG00000167680 551.6548948 1.417634327 0.000326039 0.006226699 R3HCC1L ENSG00000166024 3761.451478 0.565238054 0.000327936 0.006249091 GPR84 ENSG00000139572 179.5901382 1.170310739 0.000328665 0.006255155 TOM1 ENSG00000100284 11237.0179 0.881411671 0.00032958 0.006263218 B4GAT1 ENSG00000174684 276.7183158 -0.715102171 0.000329849 0.006263218 GCSAML ENSG00000169224 1178.49294 1.211277798 0.000331068 0.006276504 LAP3 ENSG00000002549 11714.95925 0.95890865 0.000331036 0.006276504 FRS2 ENSG00000166225 2129.784803 1.005471045 0.000334536 0.006309985 NR6A1 ENSG00000148200 506.4048796 0.770194058 0.000335545 0.006322385 METTL2A ENSG00000087995 486.4669056 -0.641824518 0.000335924 0.006322385 DLG5 ENSG00000151208 992.8152408 -1.146370181 0.000336549 0.006328068 PRR29 ENSG00000224383 264.7953347 -0.960147032 0.000337078 0.006328886

LAGE3 ENSG00000196976 572.2132057 -0.795458282 0.000338991 0.006357058 TGM2 ENSG00000198959 727.3791685 1.184542166 0.000340436 0.006379547 PICALM ENSG00000073921 24040.11527 0.625031218 0.000342481 0.006408612 DMXL2 ENSG00000104093 15541.74462 0.782650172 0.000345297 0.006438099 MAOB ENSG00000069535 15.76529939 1.881369895 0.000349481 0.006483514 HIRIP3 ENSG00000149929 1272.601914 -0.672770415 0.000349459 0.006483514 MYO10 ENSG00000145555 189.9952702 0.894872089 0.000348847 0.006483514 CHN2 ENSG00000106069 2523.16001 0.639950973 0.000350054 0.006488493 NGDN ENSG00000129460 2768.040922 0.425907111 0.000352417 0.006519345 TFG ENSG00000114354 4640.169894 0.519084057 0.000353194 0.006524417 PDZD11 ENSG00000120509 820.3453694 -0.604537887 0.00035298 0.006524417 FUK ENSG00000157353 2550.99831 -0.451224944 0.000357642 0.006578483 PLAU ENSG00000122861 120.0316911 1.22386131 0.000362957 0.006643283 CROCC2 ENSG00000226321 104.7977282 -1.246755123 0.000363518 0.006648865 NPTXR ENSG00000221890 616.6725384 -1.081322089 0.000364042 0.006653769 SASH1 ENSG00000111961 1455.185507 0.937601375 0.000364521 0.006657833 ITGA9 ENSG00000144668 180.8143075 0.940997064 0.000366436 0.006686963 ZNF14 ENSG00000105708 1484.710336 0.87368266 0.000371544 0.006762314 SLC16A13 ENSG00000174327 240.676746 -0.742434644 0.000371422 0.006762314 TRIM47 ENSG00000132481 174.9995354 -0.977425322 0.000372721 0.006770281 FLAD1 ENSG00000160688 2555.952916 -0.572226898 0.000372765 0.006770281 MTSS1L ENSG00000132613 536.9043106 0.861105095 0.00037269 0.006770281 TXNDC2 ENSG00000168454 24.70506646 1.646933046 0.000375061 0.006797713 DPYD ENSG00000188641 12470.099 0.67514297 0.000376971 0.006822804 ZNRF3 ENSG00000183579 52.83947821 -0.996583038 0.000379237 0.006854262 FAM53A ENSG00000174137 80.53409926 -0.82946518 0.000380195 0.006864037 WTAP ENSG00000146457 15082.2709 0.541543409 0.000383302 0.006908493 PCYT2 ENSG00000185813 1589.692577 -0.5620063 0.000384611 0.006922464 SMAGP ENSG00000170545 704.9179174 -0.647762309 0.000386652 0.006949555 RCAN2 ENSG00000172348 143.5004678 -1.355699174 0.000390091 0.00699916 PKN3 ENSG00000160447 329.3568575 -0.835043913 0.000390725 0.007003362 THEMIS2 ENSG00000130775 31125.19758 0.817487255 0.000391459 0.007011687 CCHCR1 ENSG00000204536 1358.932317 -0.504191518 0.000393957 0.007046698 P4HA2 ENSG00000072682 62.32565849 1.226945256 0.000394903 0.007058759 LIMA1 ENSG00000050405 1087.887913 -0.855722451 0.000399599 0.007135928 FBXL5 ENSG00000118564 28336.40593 0.672261237 0.00039977 0.007135928 SERPINB1 ENSG00000021355 25246.27495 0.730178809 0.000401083 0.007144613 C19orf12 ENSG00000131943 2371.70505 -0.547053718 0.000402217 0.007150087 SOCS6 ENSG00000170677 702.02772 0.791205165 0.000402202 0.007150087 BAHD1 ENSG00000140320 2353.899669 -0.654956588 0.000402521 0.007150604 CLU ENSG00000120885 4993.818598 1.153347408 0.000402872 0.007151947 TNS1 ENSG00000079308 692.835468 1.12438146 0.000403631 0.007156681 EPB41L2 ENSG00000079819 1784.628084 0.436981652 0.00040369 0.007156681 MTM1 ENSG00000171100 1705.590426 0.576638104 0.000404557 0.007167149 ICOSLG ENSG00000160223 1849.069044 1.066851888 0.000405535 0.007179567 ABLIM2 ENSG00000163995 84.31174832 -0.815659134 0.000408319 0.007223927

RNF167 ENSG00000108523 8361.717672 -0.615660425 0.000409165 0.007230699 CDK4 ENSG00000135446 1887.277211 -0.636885787 0.000409734 0.007234181 LRRK2 ENSG00000188906 17720.15352 0.841428297 0.000416032 0.007335396 ELMO1 ENSG00000155849 4626.785971 0.505330264 0.000416997 0.007347418 CCDC184 ENSG00000177875 20.72761549 -1.745561469 0.000419998 0.007381677 ZNF517 ENSG00000197363 870.6242922 -0.613765931 0.000421589 0.007393366 MPO ENSG00000005381 2026.286726 1.261683124 0.00042337 0.00741941 ASCL2 ENSG00000183734 696.3518773 -1.169412803 0.000425015 0.00743819 GAS1 ENSG00000180447 46.73420094 -1.631672684 0.000429765 0.0075112 HNRNPH3 ENSG00000096746 20662.17557 0.375552088 0.000432555 0.007549783 CTNNB1 ENSG00000168036 13336.40658 0.451566948 0.000436323 0.007590035 RGS17 ENSG00000091844 96.32773527 -0.920026874 0.000436965 0.007596114 SLC35G2 ENSG00000168917 68.29041116 -1.410636486 0.000437806 0.007600548 AREG ENSG00000109321 1570.320143 1.668176355 0.000440852 0.00764831 SBF1 ENSG00000100241 17417.00898 -0.531295686 0.000442828 0.007657004 HNRNPD ENSG00000138668 26441.66612 0.408274861 0.000445037 0.007659483 OPA1 ENSG00000198836 5616.250615 0.505210686 0.000444509 0.007659483 ZFPM1 ENSG00000179588 1244.798956 -0.942724794 0.000444831 0.007659483 SPRYD7 ENSG00000123178 503.8328306 -0.507651938 0.000450086 0.007730995 SNX3 ENSG00000112335 9590.057902 0.662702682 0.000452073 0.007759993 PIK3CB ENSG00000051382 2839.35157 0.603845537 0.000454566 0.007797622 PTPRE ENSG00000132334 29363.72144 0.930865554 0.000455005 0.007799999 SYAP1 ENSG00000169895 4641.156407 0.777412902 0.00045594 0.007810875 SDHAF1 ENSG00000205138 803.6347965 -0.697381463 0.000457236 0.007822742 MUC12 ENSG00000205277 49.34458752 -1.090716562 0.000459261 0.007836728 SREK1 ENSG00000153914 9312.943918 0.640855099 0.000459171 0.007836728 SH2D3C ENSG00000095370 6389.265249 -0.623047526 0.00045889 0.007836728 ADCK5 ENSG00000173137 993.2541215 -0.500027963 0.0004618 0.007854226 PGD ENSG00000142657 31260.35575 0.817968165 0.000463372 0.007870652 TIPARP ENSG00000163659 4340.719358 0.65450222 0.000465633 0.007898712 SMOX ENSG00000088826 1146.023875 1.246356762 0.000467559 0.007926201 KIF21A ENSG00000139116 974.6620072 -0.925214525 0.000468789 0.00793669 OLFML2A ENSG00000185585 108.7101148 1.241786895 0.000470194 0.007950101 SLC45A1 ENSG00000162426 55.29398212 -1.250992588 0.000472126 0.007969667 HYLS1 ENSG00000198331 314.9998726 -0.790572041 0.000473612 0.007976712 RRAGD ENSG00000025039 1389.051259 0.763477953 0.00047487 0.007988541 C11orf63 ENSG00000109944 337.3176878 -0.781184247 0.000477156 0.008020802 NUP155 ENSG00000113569 2125.620909 0.451929648 0.000480291 0.008050684 ARHGAP29 ENSG00000137962 197.3305315 1.263147282 0.000480485 0.008050684 TMEM183A ENSG00000163444 6463.187592 0.379263207 0.000481118 0.008056084 CHST10 ENSG00000115526 429.2693296 -0.705478755 0.000481436 0.008056222 FAIM ENSG00000158234 370.139418 -0.606696473 0.000485671 0.008105768 SLC7A7 ENSG00000155465 15473.8054 0.783120241 0.000485038 0.008105768 AGFG1 ENSG00000173744 6953.855489 1.175175577 0.000487928 0.008133394 TMEM131 ENSG00000075568 8523.345604 0.471674506 0.000494577 0.008228374 CFAP157 ENSG00000160401 51.18676814 -1.027318916 0.000495636 0.008240711

ABCA13 ENSG00000179869 388.4719971 1.403588898 0.000496154 0.008244026 VPS26B ENSG00000151502 10059.87777 -0.431783833 0.000504007 0.008363054 MRFAP1L1 ENSG00000178988 5143.836485 -0.625484302 0.000504321 0.008363054 SLC31A1 ENSG00000136868 3532.589568 0.571437988 0.000505826 0.008367251 IPO13 ENSG00000117408 2380.725287 -0.518434938 0.000509095 0.008405255 TPPP ENSG00000171368 328.1834853 -1.146577261 0.000509957 0.00840878 LIPA ENSG00000107798 15244.28424 0.642984359 0.000509727 0.00840878 DMKN ENSG00000161249 73.91093016 -1.036280065 0.000510728 0.008412098 MYOF ENSG00000138119 4834.296401 1.089404181 0.000512873 0.008435429 FAM117B ENSG00000138439 2484.009275 0.646222527 0.000515166 0.008461664 LIN7B ENSG00000104863 324.5664787 -0.490028511 0.00051925 0.008491874 MEI1 ENSG00000167077 1769.17432 -0.540411772 0.000518497 0.008491874 ZNF470 ENSG00000197016 294.401136 -0.821588508 0.000521727 0.008521651 BRI3 ENSG00000164713 8588.408773 0.858779307 0.000525146 0.008561329 ZNF84 ENSG00000198040 1141.791704 -1.101914548 0.000530521 0.008632695 CAPN11 ENSG00000137225 14.47954966 1.716493015 0.000531659 0.008634964 RAI1 ENSG00000108557 2708.949523 -0.522244423 0.000532058 0.008636038 XK ENSG00000047597 389.9380458 1.390861055 0.000532391 0.008636055 PPM1A ENSG00000100614 8508.845588 0.712754689 0.000533152 0.008642997 ZCWPW1 ENSG00000078487 2493.663488 0.5389492 0.000533841 0.008648762 C9orf69 ENSG00000238227 1607.897416 -1.267637874 0.000534359 0.008651756 ABCC3 ENSG00000108846 2559.210633 0.80124574 0.000536859 0.008671717 CENPT ENSG00000102901 4857.184204 -0.482105342 0.00054046 0.008716532 CETN3 ENSG00000153140 405.4104336 -0.819166019 0.000543115 0.008749855 C2orf27B ENSG00000186825 10.34838976 -1.817700628 0.000548875 0.008831683 ARSK ENSG00000164291 359.2776213 -0.873581699 0.00055076 0.008851035 TFEC ENSG00000105967 5080.192147 0.746175681 0.000551415 0.008856087 GUCD1 ENSG00000138867 8368.363888 0.510862301 0.000553909 0.008879643 ATF5 ENSG00000169136 1980.981152 0.989278134 0.000556321 0.008909496 L3MBTL2 ENSG00000100395 3824.809381 -0.467663565 0.000556457 0.008909496 GAREM1 ENSG00000141441 62.3623928 0.971081619 0.000559979 0.00894382 MS4A4A ENSG00000110079 660.8577401 0.89943726 0.000560627 0.008943979 XXYLT1 ENSG00000173950 1576.56532 0.56325616 0.000566014 0.009006948 VPS54 ENSG00000143952 4069.991451 0.535768081 0.000570148 0.00905607 SRSF10 ENSG00000188529 5616.582526 0.587071859 0.000570045 0.00905607 ARHGAP31 ENSG00000031081 3730.038304 0.537028736 0.000572787 0.009088201 COL8A2 ENSG00000171812 746.1959799 0.840398953 0.000573235 0.009088422 TBC1D8 ENSG00000204634 5181.011246 0.734485683 0.000578015 0.009147446 RAB39B ENSG00000155961 581.4770676 -0.716691564 0.000577965 0.009147446 MSRB3 ENSG00000174099 291.62767 0.733254044 0.00058449 0.009227413 FAM160B2 ENSG00000158863 6185.445205 -0.472443877 0.000586379 0.009251595 ADAMTS14 ENSG00000138316 55.42216785 -1.215177069 0.000588833 0.009273401 AGGF1 ENSG00000164252 3393.604433 -0.487295166 0.000590581 0.009278414 PTX3 ENSG00000163661 502.0022117 1.125677977 0.000590518 0.009278414 SMAD1 ENSG00000170365 436.4119827 0.854395097 0.000591855 0.009287192 ARHGAP25 ENSG00000163219 16634.1467 -0.428491567 0.000592266 0.009288016

PRDM8 ENSG00000152784 885.3269748 -0.811124277 0.000594512 0.009311984 DFFB ENSG00000169598 1773.525584 -0.530242511 0.000596581 0.009333137 KBTBD3 ENSG00000182359 318.9932886 -0.611249003 0.000597253 0.009333585 CHIC2 ENSG00000109220 2624.79767 0.625642437 0.00059878 0.009344995 USP54 ENSG00000166348 637.4540446 -0.601650465 0.000598665 0.009344995 WDR70 ENSG00000082068 3298.735563 0.444080779 0.000599979 0.009358093 ZFP3 ENSG00000180787 1092.865943 -0.851805863 0.000604169 0.009412119 PSMD6 ENSG00000163636 9999.262482 0.503305941 0.000605584 0.009422864 UBR2 ENSG00000024048 11685.98284 0.510552172 0.000605418 0.009422864 ERMP1 ENSG00000099219 1711.605536 -0.677468945 0.000608393 0.009460896 PRKAG2 ENSG00000106617 6643.832182 0.677574559 0.00060975 0.009476316 CDK2AP2 ENSG00000167797 1638.673517 -0.680305438 0.00061816 0.009572626 TFDP2 ENSG00000114126 3709.614406 -0.656613088 0.000621797 0.009606031 SH2D1B ENSG00000198574 2748.126448 -1.162662446 0.000629262 0.009709789 EPHX4 ENSG00000172031 45.91491612 -1.606203716 0.000631155 0.009733215 TMEM64 ENSG00000180694 926.5251548 -0.655412203 0.000635563 0.009795374 STPG1 ENSG00000001460 228.4684434 -0.775223128 0.000638295 0.009831636 KDELC1 ENSG00000134901 58.39000457 -0.985443235 0.000640668 0.009850647 PRMT6 ENSG00000198890 754.6938798 -0.558468984 0.000651012 0.00998603 CES4A ENSG00000172824 1062.219006 0.453940117 0.000650835 0.00998603 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 10. Significantly differential expressed genes in the comparison of ACHD with CHB

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (ACHD/CHB) adjustedb

PRSS23 ENSG00000150687 1799.50948 -2.106861837 1.43E-16 3.35E-12 CCL5 ENSG00000271503 20608.41673 -1.570709267 1.45E-12 1.10E-08 SEMA6B ENSG00000167680 427.4335592 2.151860425 1.88E-12 1.10E-08 TBX21 ENSG00000073861 5706.579712 -1.488082287 1.04E-10 3.48E-07 ANKRD22 ENSG00000152766 531.7929521 2.00307306 6.95E-10 1.48E-06 YPEL2 ENSG00000175155 2082.31329 1.686540171 8.70E-10 1.70E-06 RGS9 ENSG00000108370 828.1689478 -1.549434867 5.01E-09 7.33E-06 THBD ENSG00000178726 1071.306899 1.614825705 7.20E-09 8.68E-06 TCTN2 ENSG00000168778 311.5334677 -1.091038427 1.08E-08 1.15E-05 ADGRB2 ENSG00000121753 216.0240572 -1.448609793 1.40E-08 1.42E-05 CACNA2D2 ENSG00000007402 1833.951928 -1.555459604 1.76E-08 1.63E-05 LGR6 ENSG00000133067 1903.696607 -1.595786401 2.38E-08 2.06E-05 ZNF365 ENSG00000138311 297.1466143 -1.240631914 2.54E-08 2.12E-05 C1orf21 ENSG00000116667 2317.054525 -1.419917942 2.73E-08 2.20E-05 FRMPD3 ENSG00000147234 388.432693 -1.538892606 3.16E-08 2.46E-05 FAM20C ENSG00000177706 1801.149083 1.399337081 4.06E-08 3.01E-05 PTPRM ENSG00000173482 974.0700614 -1.330180887 4.12E-08 3.01E-05 DZANK1 ENSG00000089091 319.3349324 -0.650697319 5.14E-08 3.41E-05 COLGALT2 ENSG00000198756 455.1309472 -1.502355683 5.30E-08 3.41E-05 MAFB ENSG00000204103 15460.3625 1.723739827 5.54E-08 3.41E-05 SOX13 ENSG00000143842 886.3226158 -1.34335921 5.48E-08 3.41E-05 GNA15 ENSG00000060558 3827.405342 1.12454284 7.81E-08 4.48E-05 PPARG ENSG00000132170 134.0798062 1.895644587 1.03E-07 5.39E-05 CST7 ENSG00000077984 10156.53189 -1.309628891 1.27E-07 5.93E-05 LEXM ENSG00000162398 223.2743957 -1.350272675 1.30E-07 5.99E-05 GLB1L2 ENSG00000149328 408.6632864 -1.672204411 1.36E-07 6.00E-05 HEATR9 ENSG00000270379 241.3634327 -1.453015076 1.41E-07 6.10E-05 SOCS3 ENSG00000184557 10470.17872 1.70908644 1.75E-07 7.44E-05 NMUR1 ENSG00000171596 2034.101181 -1.635281285 4.21E-07 0.000157263 GFI1 ENSG00000162676 1790.564588 -1.228164548 5.24E-07 0.000182851 DRAM1 ENSG00000136048 877.5068393 0.975503184 5.70E-07 0.000190625 MATK ENSG00000007264 3913.214178 -1.072350757 5.65E-07 0.000190625 CERS6 ENSG00000172292 4559.660354 0.662886464 6.47E-07 0.000201812 CEP126 ENSG00000110318 330.5203905 -1.130582516 6.79E-07 0.000206302 KCNMB4 ENSG00000135643 192.9333325 1.321791842 6.75E-07 0.000206302 PKM ENSG00000067225 40005.59267 0.646579224 7.33E-07 0.000217214 KIF19 ENSG00000196169 445.8609345 -1.541182724 7.50E-07 0.000219339 B3GAT1 ENSG00000109956 1442.083083 -1.357003079 7.87E-07 0.000227488 SPIRE2 ENSG00000204991 387.3636725 -1.306712151 8.23E-07 0.000231941 LLGL2 ENSG00000073350 3410.549961 -1.094753017 9.87E-07 0.00025942 ATP1A3 ENSG00000105409 636.916143 -1.061800332 1.04E-06 0.000270167 GNLY ENSG00000115523 25442.60864 -1.122013498 1.06E-06 0.000273814

EFNA5 ENSG00000184349 80.95337837 -1.796671323 1.28E-06 0.000319666 RNF144B ENSG00000137393 11023.47488 1.415757367 1.31E-06 0.00032064 GPR153 ENSG00000158292 368.8535547 -1.109612646 1.33E-06 0.00032064 GNAO1 ENSG00000087258 445.8501024 -1.258678633 1.51E-06 0.000347108 SPON2 ENSG00000159674 6615.072351 -1.152715896 1.65E-06 0.000371398 PTCH1 ENSG00000185920 1739.276707 -1.08959615 1.69E-06 0.000376431 ACOX2 ENSG00000168306 44.70735872 1.588492339 1.73E-06 0.000382403 OSBPL7 ENSG00000006025 3939.483657 -0.789168164 2.02E-06 0.000426175 EOMES ENSG00000163508 1368.418473 -1.354647872 2.12E-06 0.000433909 FCRL6 ENSG00000181036 2817.43464 -1.320613327 2.26E-06 0.000456149 ELOVL6 ENSG00000170522 743.5719463 -0.789401753 2.37E-06 0.000470808 ICAM1 ENSG00000090339 8153.438064 1.435397243 2.50E-06 0.000481196 ALCAM ENSG00000170017 2296.275723 0.791829959 2.53E-06 0.000481947 ETS2 ENSG00000157557 10867.25789 1.365670148 2.61E-06 0.000491869 VIPR2 ENSG00000106018 56.43840635 -1.487808752 2.67E-06 0.000499239 CLIC3 ENSG00000169583 723.9562444 -1.191991266 2.84E-06 0.000528096 NECTIN2 ENSG00000130202 715.7187984 1.228940434 2.93E-06 0.000540353 SH3RF1 ENSG00000154447 456.015218 0.943677284 3.25E-06 0.00058341 MICU1 ENSG00000107745 4823.395323 0.806682654 3.27E-06 0.00058341 JCHAIN ENSG00000132465 17868.92103 1.28401398 3.51E-06 0.000613166 GZMM ENSG00000197540 2832.823168 -1.173933556 3.49E-06 0.000613166 SDC1 ENSG00000115884 37.584676 1.888724916 3.72E-06 0.000639937 ADM ENSG00000148926 1743.582829 1.628758889 3.91E-06 0.000667963 CDKN1A ENSG00000124762 7992.961462 1.395328039 4.22E-06 0.00071004 ENPP5 ENSG00000112796 239.712269 -1.343036969 4.54E-06 0.000748761 GRINA ENSG00000178719 7665.861324 1.154450268 4.78E-06 0.000776934 NTN4 ENSG00000074527 232.4621847 -1.599828037 5.05E-06 0.000809099 FAM89A ENSG00000182118 311.3356285 1.558738885 5.14E-06 0.000817079 SERBP1 ENSG00000142864 14295.97449 0.376492773 5.52E-06 0.000854655 ERLIN2 ENSG00000147475 2445.67541 0.553446604 5.75E-06 0.000878866 TNFAIP8L1 ENSG00000185361 1540.446862 0.590276649 6.28E-06 0.000941532 TTC16 ENSG00000167094 1117.858296 -1.257452732 6.51E-06 0.000954086 SYTL2 ENSG00000137501 2806.002314 -1.18740282 6.88E-06 0.000999511 IL2RB ENSG00000100385 13634.2281 -1.03063047 7.08E-06 0.001022344 COTL1 ENSG00000103187 76760.54969 0.910428805 7.17E-06 0.001029636 FZD4 ENSG00000174804 53.96027305 -1.412418634 7.29E-06 0.001040375 TSPOAP1 ENSG00000005379 5115.790115 -0.955023383 7.63E-06 0.001058338 PLIN1 ENSG00000166819 28.51372302 -1.353760019 7.61E-06 0.001058338 NID2 ENSG00000087303 146.6112663 -1.365531206 7.64E-06 0.001058338 WHRN ENSG00000095397 550.5458793 -1.101052874 7.87E-06 0.001064213 PLEKHF1 ENSG00000166289 608.9028948 -1.15760388 7.91E-06 0.001064213 CTSW ENSG00000172543 12094.35934 -1.10880671 8.28E-06 0.001101162 S100A12 ENSG00000163221 14383.75784 1.23929363 8.61E-06 0.001138015 SDC3 ENSG00000162512 759.547621 1.207349925 9.27E-06 0.001218197 TRERF1 ENSG00000124496 5213.491331 -0.521352043 9.86E-06 0.001248336 DAP ENSG00000112977 6474.95365 0.739169702 9.79E-06 0.001248336

DLG5 ENSG00000151208 997.654974 -1.283857623 9.84E-06 0.001248336 MTHFD2 ENSG00000065911 3762.938095 0.807336896 9.92E-06 0.001248336 KCNQ1 ENSG00000053918 4632.163235 0.789915493 9.91E-06 0.001248336 CNTD1 ENSG00000176563 52.8880315 -1.851384576 1.01E-05 0.001267243 LGALS9B ENSG00000170298 701.8363527 -1.386764127 1.15E-05 0.001389387 EBF4 ENSG00000088881 401.8135073 -1.16619225 1.19E-05 0.001432004 TFDP2 ENSG00000114126 3496.467609 -0.738418839 1.25E-05 0.001471624 CA2 ENSG00000104267 783.5030085 1.279408004 1.28E-05 0.001510053 TRPC3 ENSG00000138741 50.07278497 -1.565269742 1.35E-05 0.00157372 ARHGEF28 ENSG00000214944 108.8765376 -1.365969834 1.43E-05 0.001637817 PDGFD ENSG00000170962 688.8850175 -1.178264441 1.45E-05 0.001652581 FOXD2 ENSG00000186564 102.7374238 -1.006955496 1.47E-05 0.001656952 LGALS9C ENSG00000171916 288.3310089 -1.24877261 1.58E-05 0.001761463 KLRF1 ENSG00000150045 3664.137756 -1.19289567 1.68E-05 0.001849688 ENO1 ENSG00000074800 48177.07556 0.646697062 1.79E-05 0.001947965 CREG1 ENSG00000143162 10552.63829 0.93709114 1.81E-05 0.001964094 COL8A2 ENSG00000171812 632.3823847 0.99294722 2.02E-05 0.002085611 DNAH10OS ENSG00000250091 217.2773844 -0.7778085 2.08E-05 0.002085611 FOSB ENSG00000125740 4057.514072 -1.40696507 2.06E-05 0.002085611 CTD-2267D19.3 ENSG00000266208 157.0763288 1.113891965 2.08E-05 0.002085611 CTSB ENSG00000164733 42158.65142 1.251189624 2.06E-05 0.002085611 TUBB4A ENSG00000104833 96.87488695 -1.098208613 2.07E-05 0.002085611 CHIT1 ENSG00000133063 169.2281128 1.434957358 2.00E-05 0.002085611 CARMIL3 ENSG00000186648 720.8462447 -1.000602655 2.18E-05 0.002184036 KIAA1671 ENSG00000197077 913.0388889 -1.266758671 2.24E-05 0.002215417 RNF165 ENSG00000141622 465.7051836 -1.117546251 2.23E-05 0.002215417 ZFYVE28 ENSG00000159733 2511.904368 -0.852802679 2.24E-05 0.002215417 NUAK1 ENSG00000074590 239.3509605 -1.701785743 2.29E-05 0.002252597 ANKRD34A ENSG00000272031 131.6568257 -0.73503825 2.32E-05 0.002265607 SERPING1 ENSG00000149131 1763.803697 1.367571358 2.36E-05 0.002271961 BATF2 ENSG00000168062 267.4876741 1.439578258 2.37E-05 0.002271961 GZMA ENSG00000145649 6239.01541 -1.020690254 2.42E-05 0.002311554 LGALS3 ENSG00000131981 12027.96555 0.896638676 2.53E-05 0.002403451 TTC22 ENSG00000006555 918.326962 -1.040242539 2.61E-05 0.002475026 SORT1 ENSG00000134243 7659.795567 0.909704741 2.70E-05 0.002500848 SASH1 ENSG00000111961 1269.605255 0.973188924 2.68E-05 0.002500848 DNAJB7 ENSG00000172404 50.83999172 -0.921174305 2.68E-05 0.002500848 EREG ENSG00000124882 239.4096284 -1.395076113 2.70E-05 0.002500848 S100A8 ENSG00000143546 83092.50249 1.245471339 2.73E-05 0.002518891 LDHA ENSG00000134333 18865.11592 0.592220372 2.77E-05 0.00254221 SBK1 ENSG00000188322 2436.110772 -0.949859636 2.79E-05 0.002553985 FAM120C ENSG00000184083 945.4032469 -0.533588276 2.88E-05 0.002593694 OSBP2 ENSG00000184792 527.7352822 1.780624834 2.88E-05 0.002593694 HEBP1 ENSG00000013583 1954.443127 0.834468148 2.90E-05 0.002602812 LTBP4 ENSG00000090006 3206.947239 -0.788041844 2.99E-05 0.002658814 PLBD1 ENSG00000121316 29294.84519 1.126893814 3.11E-05 0.002734218

MTRNR2L12 ENSG00000269028 97.81354496 1.507577784 3.16E-05 0.002762396 E2F2 ENSG00000007968 1550.873966 1.049294454 3.28E-05 0.002826779 LIPM ENSG00000173239 22.74589667 1.656520372 3.31E-05 0.002833581 ACER3 ENSG00000078124 2437.697789 1.442445623 3.40E-05 0.00290116 JAKMIP2 ENSG00000176049 499.6058223 -1.133436515 3.42E-05 0.002908928 ITPRIPL1 ENSG00000198885 719.8769519 -0.911974208 3.44E-05 0.002913266 JAKMIP1 ENSG00000152969 1317.821298 -1.086826348 3.55E-05 0.002981012 CLIC4 ENSG00000169504 3923.462605 0.763750478 3.80E-05 0.003101911 TPRG1 ENSG00000188001 242.9939486 -0.965315381 3.91E-05 0.003164315 KLRD1 ENSG00000134539 6017.396503 -1.117425846 3.95E-05 0.003188808 DNAJC7 ENSG00000168259 4925.097171 0.658976032 4.03E-05 0.003238015 MPP1 ENSG00000130830 8326.172187 1.190305691 4.07E-05 0.003239409 RNF166 ENSG00000158717 27703.95399 -0.496091591 4.07E-05 0.003239409 AREG ENSG00000109321 1501.162731 1.375245311 4.09E-05 0.003239409 GPR84 ENSG00000139572 152.3173054 1.258030125 4.07E-05 0.003239409 ARVCF ENSG00000099889 428.6437455 -0.962795101 4.13E-05 0.003256705 DTHD1 ENSG00000197057 1614.941554 -1.260374985 4.26E-05 0.003324132 TCN2 ENSG00000185339 2160.773601 1.359614384 4.32E-05 0.003338196 HDAC9 ENSG00000048052 1959.561276 0.804990942 4.30E-05 0.003338196 CCDC136 ENSG00000128596 707.814167 -0.861777648 4.51E-05 0.003424462 FKBP1C ENSG00000198225 700.1657353 0.829208358 4.49E-05 0.003424462 GAPDH ENSG00000111640 126733.473 0.739509381 4.54E-05 0.003438746 TMEM158 ENSG00000249992 81.1030535 1.548984019 4.63E-05 0.00348257 MERTK ENSG00000153208 1300.713996 1.005435775 4.65E-05 0.003490389 GATA1 ENSG00000102145 391.8234102 1.713508765 4.69E-05 0.003507113 APOBEC3H ENSG00000100298 375.5649359 -0.871363816 4.74E-05 0.003510462 SRC ENSG00000197122 3192.655637 0.729831387 4.79E-05 0.003535581 RGL1 ENSG00000143344 474.2322691 1.064577017 4.99E-05 0.00362556 PDGFB ENSG00000100311 226.9242404 -1.040155196 5.13E-05 0.003699206 C1orf43 ENSG00000143612 5751.252351 0.608523771 5.14E-05 0.003699206 RSL1D1 ENSG00000171490 11999.55129 0.550971327 5.28E-05 0.003771827 EPSTI1 ENSG00000133106 7818.950231 0.976340128 5.29E-05 0.003771827 RAB20 ENSG00000139832 2369.313403 1.222841216 5.46E-05 0.003847545 FAM20A ENSG00000108950 295.6343243 1.548896812 5.48E-05 0.00385268 LPCAT4 ENSG00000176454 2661.64172 -0.616622732 5.70E-05 0.003920618 GPER1 ENSG00000164850 290.7411395 1.490268831 5.62E-05 0.003920618 APOBR ENSG00000184730 12658.20312 1.038194817 5.70E-05 0.003920618 GATA6 ENSG00000141448 34.69705713 -1.720542573 5.64E-05 0.003920618 CELSR2 ENSG00000143126 690.1838493 -0.787977642 5.67E-05 0.003920618 OPLAH ENSG00000178814 454.8579235 0.953420201 5.75E-05 0.003925147 PIP5K1B ENSG00000107242 592.6692434 0.549200534 5.75E-05 0.003925147 HDGF ENSG00000143321 13122.16645 0.659837004 5.91E-05 0.004001115 LUC7L ENSG00000007392 6230.230432 -0.39113511 5.95E-05 0.004012188 RBBP8 ENSG00000101773 1316.913311 0.474945425 6.05E-05 0.004056131 PGAM1 ENSG00000171314 12046.55451 0.523561471 6.04E-05 0.004056131 TBKBP1 ENSG00000198933 2158.525669 -0.859557758 6.09E-05 0.004069454

GIPR ENSG00000010310 616.7174889 -0.951231832 6.14E-05 0.004079399 RP1-122P22.4 ENSG00000268628 20.73775881 1.445505039 6.13E-05 0.004079399 EPHX4 ENSG00000172031 41.61174847 -1.58286487 6.20E-05 0.004111581 FFAR2 ENSG00000126262 1111.657491 1.408125071 6.31E-05 0.004150384 NCKAP1 ENSG00000061676 334.2396199 -0.773925666 6.29E-05 0.004150384 XBP1 ENSG00000100219 9189.208638 0.661644548 6.31E-05 0.004150384 COL6A2 ENSG00000142173 4429.665531 -1.15983801 6.46E-05 0.004237132 MMP14 ENSG00000157227 868.3729892 1.007304348 6.49E-05 0.004240772 ERBB2 ENSG00000141736 1024.876552 -0.999591824 6.51E-05 0.004245513 JDP2 ENSG00000140044 5120.637825 1.306722609 6.61E-05 0.004266938 KIAA1161 ENSG00000164976 38.62213865 -0.989615766 6.62E-05 0.004266938 PDGFRB ENSG00000113721 920.761136 -1.050160492 6.62E-05 0.004266938 ARHGAP33 ENSG00000004777 852.106259 -0.763678128 6.64E-05 0.004267615 NLRP3 ENSG00000162711 7861.88998 0.923671764 6.66E-05 0.00427108 KIF21A ENSG00000139116 861.2040628 -0.864484475 6.69E-05 0.004277964 PTPN22 ENSG00000134242 6178.024292 -0.587326791 6.86E-05 0.004376676 PRKACA ENSG00000072062 11217.6442 0.596939608 6.95E-05 0.004405122 FAM110C ENSG00000184731 60.78891766 -1.525273217 6.98E-05 0.00441527 S100A9 ENSG00000163220 264035.4269 1.17011614 7.16E-05 0.004506372 EPB41L3 ENSG00000082397 4593.770545 1.0321156 7.20E-05 0.00451503 BMPR1A ENSG00000107779 543.9389177 -0.831743671 7.23E-05 0.004526169 TTC38 ENSG00000075234 3579.481568 -0.882402262 7.29E-05 0.00454773 BCL3 ENSG00000069399 7452.150053 1.060600692 7.42E-05 0.004609053 PGD ENSG00000142657 26981.0847 0.899914678 7.43E-05 0.004609053 KIAA0930 ENSG00000100364 12350.73289 0.778004598 7.47E-05 0.00462356 DPCD ENSG00000166171 301.7432448 1.222712665 7.59E-05 0.004667943 PLPP2 ENSG00000141934 51.67508735 -1.458028596 7.58E-05 0.004667943 CUEDC1 ENSG00000180891 1574.998912 0.646355693 7.63E-05 0.004671452 LTA4H ENSG00000111144 32037.79084 0.85316859 7.67E-05 0.004688082 GSTO1 ENSG00000148834 5309.002449 0.758997435 7.82E-05 0.004765812 RALGDS ENSG00000160271 9775.849615 -0.648739441 7.89E-05 0.00478381 STAT4 ENSG00000138378 8388.788105 -0.826363902 8.00E-05 0.004811011 DFFB ENSG00000169598 1666.737837 -0.610148005 8.15E-05 0.004860483 ADAM9 ENSG00000168615 2317.007757 0.864723689 8.49E-05 0.005032006 PCBP1 ENSG00000169564 29711.99974 0.649435596 8.49E-05 0.005032006 ABHD1 ENSG00000143994 74.71986414 -0.781257288 8.54E-05 0.005041541 CNBP ENSG00000169714 26147.06202 0.572531782 8.72E-05 0.005103426 CHMP4B ENSG00000101421 13771.45943 0.617615142 8.86E-05 0.005171124 CLU ENSG00000120885 4274.903485 1.222569498 9.15E-05 0.005286212 SLC1A7 ENSG00000162383 427.5553079 -1.357355395 9.19E-05 0.00529899 CRTAP ENSG00000170275 12044.92411 0.778504641 9.42E-05 0.005400404 YBX1 ENSG00000065978 42896.70568 0.477626959 9.45E-05 0.005407832 TALDO1 ENSG00000177156 21219.94228 0.782344412 9.48E-05 0.005407832 SLCO2B1 ENSG00000137491 29.10559917 1.583947406 9.52E-05 0.005409477 BLVRB ENSG00000090013 4386.507645 1.230304558 9.53E-05 0.005409477 S100A6 ENSG00000197956 20175.21811 0.818581511 9.62E-05 0.005410499

NFKB1 ENSG00000109320 7744.383591 0.50008429 9.60E-05 0.005410499 PGK1 ENSG00000102144 29047.47029 0.495032944 9.79E-05 0.005468117 CAPG ENSG00000042493 10320.17127 0.754997549 9.86E-05 0.0054912 ALAS1 ENSG00000023330 3176.664811 0.75511967 0.000106539 0.005822935 TNNT1 ENSG00000105048 586.9765389 1.511586596 0.000108209 0.005868238 SLC2A6 ENSG00000160326 4553.361091 0.839376115 0.000108493 0.005868238 PSAP ENSG00000197746 286448.0801 0.686124791 0.000108913 0.005872043 ADAM22 ENSG00000008277 411.4544212 -0.783747004 0.000110356 0.005936119 CAMK2N1 ENSG00000162545 161.7607036 -1.171177193 0.000111034 0.005958901 CEBPB ENSG00000172216 9482.085485 1.225734081 0.000113264 0.006038617 TUBE1 ENSG00000074935 851.2047143 -0.661074059 0.000113293 0.006038617 EPB41L4A ENSG00000129595 218.5095349 -1.170487355 0.000113942 0.006059369 TBC1D19 ENSG00000109680 268.6400259 -0.796282017 0.000115535 0.00611628 SYNE2 ENSG00000054654 20632.80378 -0.8232294 0.000119654 0.006291663 SMPDL3A ENSG00000172594 1407.454893 0.983355138 0.000119924 0.006291688 HCCS ENSG00000004961 771.6985853 0.684577659 0.000120775 0.006322156 BNIP3L ENSG00000104765 17449.19456 1.309848706 0.000121658 0.006354206 ANKRD13B ENSG00000198720 165.237826 -0.836310634 0.000123898 0.006428314 PANX2 ENSG00000073150 415.1729885 1.332588389 0.000123687 0.006428314 OTUD7B ENSG00000264522 617.7901702 -0.72924385 0.00012403 0.006428314 PLA2G4A ENSG00000116711 456.0322875 0.883963097 0.000124759 0.006444241 MYO3B ENSG00000071909 63.24759101 -1.529636658 0.00012516 0.006450687 RBP7 ENSG00000162444 2860.288602 0.898945877 0.00012601 0.00646717 XK ENSG00000047597 331.2011353 1.421245929 0.000133345 0.006709983 F2R ENSG00000181104 2129.44795 -0.94999957 0.000134955 0.006761889 SLC39A11 ENSG00000133195 1807.195233 0.58772955 0.000138246 0.006912025 MDK ENSG00000110492 253.9659808 -1.017905062 0.000139719 0.006947524 HADHA ENSG00000084754 20581.86959 0.509602891 0.000139847 0.006947524 UBASH3B ENSG00000154127 3339.901073 0.53940917 0.000145224 0.007199334 BRI3 ENSG00000164713 7573.695004 0.860231538 0.000151087 0.007458425 CYBB ENSG00000165168 82685.35546 0.852453857 0.000152244 0.007483924 CBWD1 ENSG00000172785 2595.992256 0.690597528 0.000155256 0.007576747 CD1D ENSG00000158473 6719.343912 0.846587049 0.000154805 0.007576747 NCALD ENSG00000104490 1216.24012 -1.065458471 0.000157641 0.007647738 PIM1 ENSG00000137193 14204.34612 1.049648121 0.000157809 0.007647738 NCOA4 ENSG00000266412 35354.80264 0.977285877 0.000158695 0.0076563 LAG3 ENSG00000089692 844.0237806 -0.937338736 0.000161679 0.007784204 LAIR2 ENSG00000167618 456.4459774 -1.195603839 0.000164647 0.007894625 MTHFR ENSG00000177000 8230.695385 0.605180334 0.000168189 0.007998905 SLC25A25 ENSG00000148339 2328.59542 0.671732146 0.000169 0.008021176 NPRL2 ENSG00000114388 2004.472168 -0.42460363 0.000169674 0.008036837 PROSER2 ENSG00000148426 166.095922 0.966469264 0.000172396 0.008097905 CEP72 ENSG00000112877 507.2044465 -0.654150896 0.000173136 0.008097905 CEP78 ENSG00000148019 4318.244951 -0.975804084 0.000173386 0.008097905 KYNU ENSG00000115919 4022.61432 0.863390178 0.000173081 0.008097905 RELB ENSG00000104856 2611.061555 0.814044297 0.000174081 0.008105201

GK5 ENSG00000175066 6055.591073 -0.80686387 0.000174235 0.008105201 ATP6V0D1 ENSG00000159720 10791.00546 0.769619512 0.000175723 0.008142042 IFNAR1 ENSG00000142166 6175.060793 0.661751495 0.000176234 0.008149588 TGFBR3 ENSG00000069702 4353.133025 -0.985507457 0.000177685 0.008184349 RGS17 ENSG00000091844 88.66871478 -0.919133119 0.000181986 0.008365971 SCN8A ENSG00000196876 151.3792946 -0.747040607 0.000185922 0.008484286 BMF ENSG00000104081 7194.294687 0.737049721 0.000190778 0.008667974 TMEM170B ENSG00000205269 5400.377791 1.25318513 0.000191341 0.008676722 GSTZ1 ENSG00000100577 546.0129279 0.673841648 0.000192181 0.008677059 RCAN2 ENSG00000172348 136.8108093 -1.333871798 0.000194067 0.008732639 SMOX ENSG00000088826 982.628554 1.273558112 0.000197188 0.008829586 TSC22D3 ENSG00000157514 65627.24365 0.811620664 0.000197353 0.008829586 MYDGF ENSG00000074842 3462.180612 0.65688309 0.00020848 0.009239068 CCNY ENSG00000108100 12565.71835 0.477181117 0.00020803 0.009239068 CAPNS1 ENSG00000126247 19918.82251 0.702618924 0.000212327 0.009338813 MSC ENSG00000178860 194.0438525 -0.894839838 0.000212325 0.009338813 DDIT4 ENSG00000168209 8998.026415 0.964945769 0.00021373 0.009382868 ETV7 ENSG00000010030 378.2374169 1.37895031 0.000214613 0.009386428 PPIF ENSG00000108179 7040.847738 1.000447836 0.000225919 0.00974401 SLC1A5 ENSG00000105281 4180.595916 0.977424053 0.000229074 0.009800241 PCDH12 ENSG00000113555 444.1741381 -0.557530406 0.000229101 0.009800241 SCPEP1 ENSG00000121064 13350.38796 0.743353956 0.000231369 0.009879194 TNFAIP6 ENSG00000123610 193.9885944 1.313599397 0.000232244 0.009898503 CBX3 ENSG00000122565 5104.479419 0.420485282 0.00023427 0.009948621 TPPP ENSG00000171368 264.7231832 -0.929891124 0.00023402 0.009948621 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 11. Significantly differential expressed genes in the comparison of ACHD with NC

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (ACHD/NC) adjustedb

CEBPB ENSG00000172216 7052.925004 3.071317152 3.23E-24 1.01E-19 EOMES ENSG00000163508 2275.319738 -1.99314895 1.64E-15 7.77E-12 GNA15 ENSG00000060558 3550.710412 1.488776547 1.75E-15 7.77E-12 PPIF ENSG00000108179 5942.75122 1.811364334 3.31E-15 1.29E-11 MAFB ENSG00000204103 13723.80815 2.343430855 1.18E-14 3.35E-11 PABPC1 ENSG00000070756 102457.5277 0.593253204 1.13E-14 3.35E-11 BCL3 ENSG00000069399 6510.283375 1.714884965 2.48E-14 6.43E-11 GRINA ENSG00000178719 6856.274585 1.693239881 4.38E-14 9.10E-11 TRIM17 ENSG00000162931 169.1400409 -1.213307241 5.82E-14 1.07E-10 TNFRSF12A ENSG00000006327 232.3549463 2.118110946 3.08E-13 4.80E-10 CCL5 ENSG00000271503 23479.60317 -1.545185084 4.32E-13 6.12E-10 RAB20 ENSG00000139832 2088.849 1.862680035 7.27E-13 9.85E-10 ZNF234 ENSG00000263002 902.8317793 -1.042683602 7.78E-13 1.01E-09 ZNF385A ENSG00000161642 9717.959038 1.103901008 1.14E-12 1.37E-09 ENPP5 ENSG00000112796 370.11992 -1.860865508 1.21E-12 1.39E-09 ZNF582 ENSG00000018869 238.3166461 -1.126190507 1.45E-12 1.51E-09 CREG1 ENSG00000143162 9861.182353 1.286129272 1.75E-12 1.71E-09 TBX21 ENSG00000073861 6747.331132 -1.533654046 2.00E-12 1.89E-09 ICAM1 ENSG00000090339 7517.645146 1.852849907 2.65E-12 2.34E-09 PDGFB ENSG00000100311 370.9943934 -1.672436341 2.78E-12 2.34E-09 KCNQ1 ENSG00000053918 4314.65325 1.147319341 2.73E-12 2.34E-09 RIPK2 ENSG00000104312 3594.005773 1.045445036 2.97E-12 2.43E-09 PRKACA ENSG00000072062 10691.39831 0.88796791 3.57E-12 2.86E-09 NLRP3 ENSG00000162711 7158.088825 1.37610328 4.75E-12 3.50E-09 TTC22 ENSG00000006555 1256.17739 -1.394293355 6.19E-12 4.19E-09 BRI3 ENSG00000164713 6817.161967 1.353276771 7.53E-12 4.79E-09 GDF11 ENSG00000135414 1161.082752 -1.130001282 8.11E-12 5.05E-09 SERTAD2 ENSG00000179833 7575.591842 0.90632637 9.95E-12 5.96E-09 IER5L ENSG00000188483 453.0409695 1.319898546 1.33E-11 7.25E-09 PIP5K1B ENSG00000107242 587.2192342 0.722665134 1.43E-11 7.64E-09 COLGALT2 ENSG00000198756 544.7516093 -1.605254066 1.56E-11 8.10E-09 LGALS3 ENSG00000131981 11160.78016 1.269173918 1.60E-11 8.17E-09 UNC93B1 ENSG00000110057 9507.742695 1.144096246 1.92E-11 9.64E-09 FCRL6 ENSG00000181036 3980.434494 -1.692049844 2.29E-11 1.13E-08 PRSS23 ENSG00000150687 1862.568115 -1.878463968 2.50E-11 1.22E-08 FAM20C ENSG00000177706 1794.317139 1.447190468 2.55E-11 1.22E-08 C16orf87 ENSG00000155330 1272.759729 0.899127415 2.78E-11 1.27E-08 EXT1 ENSG00000182197 1813.47203 0.860294147 3.21E-11 1.39E-08 GZMA ENSG00000145649 8914.764845 -1.438290767 3.60E-11 1.53E-08 SLC30A1 ENSG00000170385 4464.6953 1.175150439 4.37E-11 1.84E-08 SOCS1 ENSG00000185338 274.479473 1.914115195 4.71E-11 1.90E-08 TTYH3 ENSG00000136295 10340.90123 1.169805766 4.66E-11 1.90E-08

BCL11A ENSG00000119866 2354.763602 0.730415047 4.85E-11 1.94E-08 SDC4 ENSG00000124145 254.8462887 1.31804801 6.74E-11 2.52E-08 DDX21 ENSG00000165732 14988.06017 0.876822655 6.78E-11 2.52E-08 CHMP4B ENSG00000101421 13344.116 0.853813567 7.31E-11 2.68E-08 JRKL ENSG00000183340 897.7980939 -1.195930032 8.15E-11 2.94E-08 ZNF74 ENSG00000185252 719.9153208 -1.089295726 8.98E-11 3.14E-08 PLBD1 ENSG00000121316 28250.80219 1.362038545 9.11E-11 3.15E-08 DENND1A ENSG00000119522 6191.596483 0.977798944 1.09E-10 3.56E-08 SLAMF6 ENSG00000162739 9918.361971 -1.323665574 1.08E-10 3.56E-08 YOD1 ENSG00000180667 4794.428151 1.166384409 1.13E-10 3.67E-08 DCLRE1A ENSG00000198924 749.7856203 -1.069022662 1.38E-10 4.35E-08 CERS6 ENSG00000172292 4615.872389 0.751716663 1.38E-10 4.35E-08 SDC3 ENSG00000162512 680.62263 1.713467409 1.76E-10 5.26E-08 VCAN ENSG00000038427 67937.09772 1.094020696 1.84E-10 5.45E-08 SNN ENSG00000184602 14379.34947 1.116643487 1.95E-10 5.72E-08 RGS9 ENSG00000108370 960.3545551 -1.574850888 2.00E-10 5.82E-08 YBX1 ENSG00000065978 41147.87396 0.754775682 2.05E-10 5.93E-08 NR6A1 ENSG00000148200 434.3626 0.991726043 2.30E-10 6.50E-08 KIAA1161 ENSG00000164976 56.04108547 -1.436401162 2.43E-10 6.83E-08 FRMPD3 ENSG00000147234 462.2784067 -1.616602087 2.86E-10 7.97E-08 FBP1 ENSG00000165140 3448.199288 1.123836825 3.21E-10 8.86E-08 TCTN2 ENSG00000168778 375.6411928 -1.1879343 3.95E-10 1.02E-07 RGS3 ENSG00000138835 3684.309159 -0.988446307 3.94E-10 1.02E-07 TMEM160 ENSG00000130748 385.5211418 1.237808876 4.32E-10 1.09E-07 THEMIS2 ENSG00000130775 25871.52706 1.137282416 5.83E-10 1.43E-07 CDKN1A ENSG00000124762 7275.999045 1.833212805 5.82E-10 1.43E-07 OPLAH ENSG00000178814 426.090198 1.291691592 5.98E-10 1.46E-07 RELB ENSG00000104856 2460.09194 1.1361438 6.55E-10 1.58E-07 PGD ENSG00000142657 25896.33218 1.151982346 7.68E-10 1.81E-07 LGALS9C ENSG00000171916 342.425739 -1.375227435 8.58E-10 1.97E-07 TXNL4A ENSG00000141759 2955.279978 0.554037652 9.01E-10 2.05E-07 PTGER3 ENSG00000050628 361.9822878 2.371367442 9.92E-10 2.19E-07 NECTIN2 ENSG00000130202 655.8140528 1.621017714 1.08E-09 2.32E-07 ANKRD34A ENSG00000272031 169.7515964 -1.002308288 1.24E-09 2.57E-07 MTHFD2 ENSG00000065911 3847.008644 0.851632749 1.26E-09 2.58E-07 PDGFD ENSG00000170962 926.5487986 -1.481761095 1.27E-09 2.58E-07 RAB34 ENSG00000109113 1468.330214 1.063495292 1.43E-09 2.81E-07 KLRD1 ENSG00000134539 7924.166235 -1.400363199 1.52E-09 2.96E-07 ATF5 ENSG00000169136 1725.220872 1.139448342 1.54E-09 2.98E-07 PLK3 ENSG00000173846 5242.938011 1.415453066 1.56E-09 2.98E-07 JAKMIP2 ENSG00000176049 716.6882309 -1.537852074 1.55E-09 2.98E-07 TIGD7 ENSG00000140993 703.6263537 -1.132547598 1.60E-09 3.03E-07 RNF144B ENSG00000137393 10686.33079 1.580412116 1.66E-09 3.12E-07 CTSA ENSG00000064601 16121.79791 0.9759548 1.70E-09 3.17E-07 MPP1 ENSG00000130830 7788.391861 1.539495139 1.75E-09 3.23E-07 TUBB4A ENSG00000104833 132.6306378 -1.429472738 1.92E-09 3.50E-07

FTH1 ENSG00000167996 140614.4481 1.122446265 1.97E-09 3.54E-07 H2AFY ENSG00000113648 22850.76331 0.718916686 1.98E-09 3.54E-07 GRK3 ENSG00000100077 6384.804397 0.887268326 2.12E-09 3.75E-07 MATK ENSG00000007264 4919.572065 -1.248558699 2.14E-09 3.76E-07 CST7 ENSG00000077984 11419.12739 -1.296803678 2.22E-09 3.89E-07 ETS2 ENSG00000157557 10340.79769 1.608614217 2.31E-09 3.99E-07 SMCO4 ENSG00000166002 1661.16355 1.245388289 2.46E-09 4.23E-07 STRAP ENSG00000023734 6052.087465 0.576102898 2.50E-09 4.26E-07 PTCH1 ENSG00000185920 2201.255164 -1.280465872 2.56E-09 4.31E-07 WDCP ENSG00000163026 632.0745458 -0.972239493 2.66E-09 4.46E-07 ZNF579 ENSG00000218891 444.2240568 0.886224482 2.86E-09 4.74E-07 SOCS3 ENSG00000184557 10323.58512 1.75762952 2.99E-09 4.93E-07 F2R ENSG00000181104 2658.847734 -1.156360695 3.15E-09 5.11E-07 SCPEP1 ENSG00000121064 12984.84796 0.960857591 3.20E-09 5.17E-07 YBX3 ENSG00000060138 6711.86963 1.506242565 3.28E-09 5.23E-07 C4orf48 ENSG00000243449 92.15905847 2.387232261 3.48E-09 5.53E-07 PPARG ENSG00000132170 130.0539689 1.990096133 3.57E-09 5.65E-07 TMEM167A ENSG00000174695 11273.73748 0.746351533 4.15E-09 6.47E-07 JDP2 ENSG00000140044 4720.403522 1.728561735 4.35E-09 6.70E-07 UBE2R2 ENSG00000107341 9881.704831 0.873420822 4.41E-09 6.77E-07 CXCL16 ENSG00000161921 3983.500697 1.362293935 4.56E-09 6.93E-07 POLH ENSG00000170734 1125.435825 -0.876385263 4.59E-09 6.95E-07 APLP2 ENSG00000084234 64292.33177 0.986501331 4.98E-09 7.42E-07 OGFOD1 ENSG00000087263 1882.417588 -0.630267376 5.43E-09 7.98E-07 SLC26A11 ENSG00000181045 2564.598447 -0.65767564 5.48E-09 8.02E-07 PSAP ENSG00000197746 277387.9612 0.917170312 5.60E-09 8.15E-07 HEATR9 ENSG00000270379 258.3727251 -1.37101139 5.82E-09 8.44E-07 OSGEPL1 ENSG00000128694 745.8707963 -1.056943979 5.86E-09 8.45E-07 STAB1 ENSG00000010327 22825.51106 1.167091099 6.46E-09 9.19E-07 CSDE1 ENSG00000009307 44458.58385 0.413007472 6.58E-09 9.31E-07 HMGB3 ENSG00000029993 496.4616619 1.307859115 6.66E-09 9.31E-07 RTKN ENSG00000114993 96.47898964 -1.206678015 6.71E-09 9.34E-07 TCN2 ENSG00000185339 2008.130654 1.739060615 6.85E-09 9.45E-07 MIDN ENSG00000167470 14796.01354 0.968185742 7.04E-09 9.57E-07 MLXIPL ENSG00000009950 15.77543469 2.6469591 7.21E-09 9.69E-07 IL2RB ENSG00000100385 16642.24845 -1.1713018 7.34E-09 9.81E-07 CDKN2D ENSG00000129355 8337.100143 1.136710765 7.47E-09 9.91E-07 PLEKHF1 ENSG00000166289 797.3988164 -1.405477216 8.29E-09 1.07E-06 LGR6 ENSG00000133067 2053.590423 -1.516915579 8.33E-09 1.07E-06 ACOX2 ENSG00000168306 40.64195291 1.997039141 8.87E-09 1.13E-06 ADGRB2 ENSG00000121753 245.1367526 -1.427528059 9.42E-09 1.19E-06 GPER1 ENSG00000164850 264.0480103 2.004453218 1.01E-08 1.26E-06 NR4A3 ENSG00000119508 266.4907273 2.178945628 1.02E-08 1.27E-06 ZNF365 ENSG00000138311 368.9645502 -1.36336281 1.10E-08 1.35E-06 UBE2E2 ENSG00000182247 1280.403013 1.028754506 1.12E-08 1.37E-06 OSCAR ENSG00000170909 4927.422365 0.854924017 1.16E-08 1.40E-06

SPEF2 ENSG00000152582 856.9695101 -0.967475041 1.16E-08 1.40E-06 CEP89 ENSG00000121289 1119.823253 -0.861782458 1.15E-08 1.40E-06 AGAP2 ENSG00000135439 4211.605257 -0.70810749 1.17E-08 1.40E-06 GAS2 ENSG00000148935 65.12863679 -1.459404012 1.20E-08 1.44E-06 IFT46 ENSG00000118096 522.1910976 -0.627512722 1.26E-08 1.49E-06 CLIC4 ENSG00000169504 3985.410059 0.833541042 1.28E-08 1.50E-06 STX11 ENSG00000135604 14453.38086 1.034558617 1.34E-08 1.57E-06 SOWAHC ENSG00000198142 307.5244176 1.24682227 1.40E-08 1.62E-06 USP3 ENSG00000140455 16323.32244 0.637828321 1.39E-08 1.62E-06 FOXO3 ENSG00000118689 7803.594448 1.078119946 1.44E-08 1.66E-06 KYNU ENSG00000115919 3734.561056 1.227180635 1.44E-08 1.66E-06 ITPRIPL1 ENSG00000198885 940.0253679 -1.1771121 1.54E-08 1.77E-06 OGFR ENSG00000060491 14082.72262 0.828619847 1.55E-08 1.77E-06 C1orf21 ENSG00000116667 2448.9634 -1.294873464 1.59E-08 1.81E-06 LBH ENSG00000213626 12020.02497 -1.358394112 1.65E-08 1.86E-06 CAPNS1 ENSG00000126247 19280.15672 0.934099621 1.71E-08 1.90E-06 RAB13 ENSG00000143545 682.9802345 1.41393891 1.81E-08 1.99E-06 ETF1 ENSG00000120705 7359.603379 0.757948811 1.84E-08 2.01E-06 NPRL2 ENSG00000114388 2371.806331 -0.566883714 1.89E-08 2.05E-06 UBASH3B ENSG00000154127 3436.740868 0.599359633 1.95E-08 2.11E-06 FKBP1C ENSG00000198225 699.2567049 0.947760428 1.97E-08 2.11E-06 CTD-2547L24.3 ENSG00000258875 640.3335452 -1.189607105 1.99E-08 2.13E-06 KIF21A ENSG00000139116 1085.16552 -1.076159769 2.15E-08 2.27E-06 MYO10 ENSG00000145555 158.670966 1.17916416 2.22E-08 2.33E-06 NMUR1 ENSG00000171596 2475.57615 -1.751226671 2.34E-08 2.42E-06 ZNF226 ENSG00000167380 1271.01417 -0.959328877 2.33E-08 2.42E-06 IER5 ENSG00000162783 8994.730906 0.953702365 2.50E-08 2.53E-06 BRD8 ENSG00000112983 3447.491711 -0.691685626 2.52E-08 2.54E-06 ARRB2 ENSG00000141480 40340.3949 0.804588164 2.63E-08 2.60E-06 DOK4 ENSG00000125170 175.5645811 -1.286711551 2.62E-08 2.60E-06 AKIRIN2 ENSG00000135334 5457.258204 0.700129402 2.65E-08 2.60E-06 FAM198B ENSG00000164125 7795.282067 1.060907339 2.66E-08 2.60E-06 MMACHC ENSG00000132763 255.7794693 -0.898562941 2.73E-08 2.65E-06 CENPQ ENSG00000031691 320.6492146 -0.982634593 2.76E-08 2.66E-06 CARD19 ENSG00000165233 3820.46789 0.964731157 2.79E-08 2.67E-06 ZNF470 ENSG00000197016 347.896265 -1.08436387 2.86E-08 2.73E-06 CTSB ENSG00000164733 41057.57811 1.42419788 2.90E-08 2.76E-06 RBP7 ENSG00000162444 2733.020925 1.159562421 2.96E-08 2.81E-06 CST3 ENSG00000101439 28771.50036 1.119180298 2.99E-08 2.83E-06 CTSZ ENSG00000101160 38325.69909 0.939020326 3.08E-08 2.91E-06 PLCE1 ENSG00000138193 333.5223784 -0.950650818 3.15E-08 2.94E-06 CDC42EP4 ENSG00000179604 983.4711439 1.080223418 3.22E-08 2.98E-06 KIAA1671 ENSG00000197077 1119.664378 -1.429332094 3.22E-08 2.98E-06 GFI1 ENSG00000162676 2045.902393 -1.238743659 3.29E-08 3.02E-06 KIF1BP ENSG00000198954 764.1307162 -0.727294332 3.42E-08 3.11E-06 SMPDL3A ENSG00000172594 1372.88764 1.174995394 3.44E-08 3.12E-06

CDYL2 ENSG00000166446 1616.689318 0.664423203 3.45E-08 3.12E-06 XXYLT1 ENSG00000173950 1391.192547 0.723963887 3.47E-08 3.12E-06 MBD2 ENSG00000134046 11810.07196 0.558070279 3.75E-08 3.33E-06 SLC9A9 ENSG00000181804 2471.544149 0.534529731 3.83E-08 3.39E-06 TGFB1 ENSG00000105329 23916.2006 0.814854274 3.92E-08 3.45E-06 SORT1 ENSG00000134243 7350.765524 1.145607791 3.99E-08 3.50E-06 KLRB1 ENSG00000111796 8218.455363 -1.155075531 4.00E-08 3.50E-06 UGGT2 ENSG00000102595 473.2665668 0.967381739 4.10E-08 3.58E-06 GAREM1 ENSG00000141441 52.67833869 1.215118077 4.25E-08 3.67E-06 SLCO2B1 ENSG00000137491 25.38665283 2.307780056 4.34E-08 3.74E-06 MAFF ENSG00000185022 1688.732853 1.694493478 4.37E-08 3.75E-06 UPP1 ENSG00000183696 12803.80558 1.093419949 4.50E-08 3.85E-06 HLX ENSG00000136630 1722.755621 1.366545126 4.54E-08 3.88E-06 H1FX ENSG00000184897 9264.623424 1.044412504 4.62E-08 3.92E-06 NINJ1 ENSG00000131669 10083.97577 1.275421227 4.88E-08 4.10E-06 PLIN1 ENSG00000166819 34.72897963 -1.492386802 4.89E-08 4.10E-06 TFAP2E ENSG00000116819 1445.552371 -0.746462902 4.90E-08 4.10E-06 FASLG ENSG00000117560 581.8289059 -1.787324611 5.00E-08 4.17E-06 CUEDC1 ENSG00000180891 1535.708307 0.854912522 5.13E-08 4.25E-06 SMARCD3 ENSG00000082014 4571.784562 1.008355114 5.12E-08 4.25E-06 TLR3 ENSG00000164342 147.8436627 -1.443331534 5.33E-08 4.37E-06 SH3RF1 ENSG00000154447 449.5411007 1.081539838 5.39E-08 4.41E-06 NPC2 ENSG00000119655 12026.85657 0.915659537 5.44E-08 4.42E-06 ZNF787 ENSG00000142409 2350.014099 0.889865396 5.53E-08 4.49E-06 CITED4 ENSG00000179862 460.5318413 1.349953571 5.61E-08 4.54E-06 TAS2R4 ENSG00000127364 160.2683209 -1.21228261 5.88E-08 4.73E-06 HDGF ENSG00000143321 13063.14886 0.803128623 5.93E-08 4.76E-06 BCS1L ENSG00000074582 1188.545936 -0.755517974 5.97E-08 4.78E-06 ADIPOR1 ENSG00000159346 15254.76382 1.066581561 6.05E-08 4.82E-06 DIAPH2 ENSG00000147202 2750.503876 0.768997329 6.05E-08 4.82E-06 AURKB ENSG00000178999 194.253538 1.023375604 6.09E-08 4.84E-06 E2F2 ENSG00000007968 1509.546815 1.234263594 6.15E-08 4.88E-06 SETD7 ENSG00000145391 3664.355667 0.792768459 6.28E-08 4.97E-06 P2RX4 ENSG00000135124 3679.186786 0.724475858 6.35E-08 5.01E-06 RILP ENSG00000167705 726.3546165 1.120776043 6.61E-08 5.16E-06 EPHX4 ENSG00000172031 64.40115289 -2.0876621 6.93E-08 5.37E-06 HSPH1 ENSG00000120694 4093.564057 -0.73896918 7.30E-08 5.63E-06 RINL ENSG00000187994 2466.891992 -0.706534732 7.37E-08 5.67E-06 ANP32B ENSG00000136938 18353.87629 0.661283417 7.49E-08 5.75E-06 TUBE1 ENSG00000074935 1052.607038 -0.85867284 7.80E-08 5.94E-06 NCALD ENSG00000104490 1574.354153 -1.320245532 8.05E-08 6.10E-06 CHST11 ENSG00000171310 7441.214759 0.598359177 8.15E-08 6.16E-06 S100A9 ENSG00000163220 264852.3871 1.254075533 8.63E-08 6.50E-06 C11orf45 ENSG00000174370 75.30735533 -1.167880141 9.04E-08 6.79E-06 LONRF1 ENSG00000154359 2242.344863 0.900613699 9.10E-08 6.80E-06 CACNA2D2 ENSG00000007402 1810.16673 -1.326169813 9.18E-08 6.84E-06

MFSD14A ENSG00000156875 6513.266035 0.502550795 9.25E-08 6.88E-06 GLB1L2 ENSG00000149328 409.60159 -1.515344685 9.31E-08 6.89E-06 GNS ENSG00000135677 24156.08622 0.788630195 9.29E-08 6.89E-06 TRIM68 ENSG00000167333 913.0350212 -0.786730257 9.44E-08 6.97E-06 RGS17 ENSG00000091844 132.254759 -1.388821812 9.74E-08 7.14E-06 ARHGAP25 ENSG00000163219 17327.10586 -0.513292523 1.02E-07 7.38E-06 TPRG1 ENSG00000188001 293.3900884 -1.094189463 1.03E-07 7.49E-06 DAP ENSG00000112977 6696.557538 0.751800322 1.05E-07 7.58E-06 ABCC10 ENSG00000124574 3121.490967 -0.549401396 1.07E-07 7.70E-06 ZNF425 ENSG00000204947 98.5569646 -1.252849836 1.13E-07 8.08E-06 CCNY ENSG00000108100 12589.21495 0.621203616 1.14E-07 8.15E-06 COQ6 ENSG00000119723 1404.063325 -0.447677178 1.16E-07 8.29E-06 P4HA2 ENSG00000072682 52.93713131 1.421110364 1.20E-07 8.53E-06 GRASP ENSG00000161835 4655.865912 1.769480023 1.22E-07 8.65E-06 ANAPC15 ENSG00000110200 1837.229744 0.697979303 1.25E-07 8.83E-06 C18orf54 ENSG00000166845 264.655424 -0.794075566 1.28E-07 9.02E-06 RHOG ENSG00000177105 13700.82383 0.973779014 1.30E-07 9.07E-06 GZMM ENSG00000197540 3195.064626 -1.171954472 1.32E-07 9.19E-06 C10orf11 ENSG00000148655 356.9757428 1.072784818 1.34E-07 9.35E-06 LEXM ENSG00000162398 285.1178576 -1.49471439 1.38E-07 9.55E-06 MAPK6 ENSG00000069956 3067.19056 0.857854905 1.37E-07 9.55E-06 APBB2 ENSG00000163697 121.4123939 1.7397111 1.41E-07 9.76E-06 PTX3 ENSG00000163661 406.0854287 1.493354581 1.43E-07 9.86E-06 NFKBIA ENSG00000100906 34243.78995 1.407680157 1.48E-07 1.02E-05 ACKR3 ENSG00000144476 263.8416627 -1.177605097 1.50E-07 1.03E-05 FCRLB ENSG00000162746 136.8345803 -1.234145906 1.51E-07 1.03E-05 ERBB2 ENSG00000141736 1442.158226 -1.363902463 1.51E-07 1.03E-05 GPR68 ENSG00000119714 660.0084466 -0.993564441 1.53E-07 1.04E-05 C19orf38 ENSG00000214212 8727.046424 1.004631645 1.54E-07 1.04E-05 GRPEL1 ENSG00000109519 2597.438909 0.751009059 1.53E-07 1.04E-05 ZNF804A ENSG00000170396 319.9527687 1.219385392 1.55E-07 1.04E-05 FEZ1 ENSG00000149557 385.1341929 -1.523867142 1.60E-07 1.07E-05 SRC ENSG00000197122 3072.151425 0.969562527 1.61E-07 1.08E-05 LAPTM5 ENSG00000162511 166550.8293 0.670704916 1.63E-07 1.09E-05 ZKSCAN3 ENSG00000189298 572.353916 -0.959021909 1.65E-07 1.10E-05 TBC1D31 ENSG00000156787 1428.525663 -0.810113901 1.71E-07 1.13E-05 CD2 ENSG00000116824 11549.51685 -1.052554605 1.73E-07 1.14E-05 TNFRSF21 ENSG00000146072 412.1907138 1.531584185 1.78E-07 1.17E-05 DLG5 ENSG00000151208 1121.868966 -1.297864095 1.81E-07 1.19E-05 ADAM9 ENSG00000168615 2324.928203 0.963324049 1.83E-07 1.20E-05 GIN1 ENSG00000145723 530.313648 -0.998122702 1.87E-07 1.22E-05 FUT2 ENSG00000176920 69.79969197 -1.203004872 1.87E-07 1.22E-05 S100A12 ENSG00000163221 14311.13672 1.312209213 1.88E-07 1.22E-05 CD40LG ENSG00000102245 2258.014283 -1.115452665 1.90E-07 1.23E-05 ECHDC3 ENSG00000134463 737.0446277 1.860320596 1.94E-07 1.25E-05 CD36 ENSG00000135218 22655.41117 1.33230513 1.95E-07 1.25E-05

JAKMIP1 ENSG00000152969 1512.110437 -1.130630735 2.04E-07 1.31E-05 RBBP8 ENSG00000101773 1308.32126 0.642222939 2.08E-07 1.32E-05 MFSD2A ENSG00000168389 692.1460415 0.920437319 2.08E-07 1.32E-05 ITLN1 ENSG00000179914 140.8646103 2.073728296 2.10E-07 1.33E-05 SOX13 ENSG00000143842 891.1029664 -1.12912852 2.11E-07 1.34E-05 RNF130 ENSG00000113269 20828.8504 0.85548084 2.12E-07 1.34E-05 HTRA2 ENSG00000115317 1682.413705 -0.521116314 2.13E-07 1.34E-05 WASL ENSG00000106299 1062.586974 0.901970585 2.21E-07 1.38E-05 CHN2 ENSG00000106069 2397.104523 0.566716108 2.22E-07 1.38E-05 MAP4K4 ENSG00000071054 17278.80202 0.485144936 2.22E-07 1.38E-05 DHRS13 ENSG00000167536 860.0746124 -0.674536279 2.24E-07 1.39E-05 ZNF436 ENSG00000125945 936.0116192 -0.640511903 2.23E-07 1.39E-05 LACTB ENSG00000103642 3499.935836 0.927063671 2.27E-07 1.39E-05 SH2B2 ENSG00000160999 947.58584 1.034854845 2.31E-07 1.42E-05 ZNF692 ENSG00000171163 2537.164746 -0.690230764 2.35E-07 1.44E-05 PNKD ENSG00000127838 5167.86563 0.971439809 2.35E-07 1.44E-05 SP4 ENSG00000105866 2456.372517 -0.749872429 2.36E-07 1.44E-05 ZMYM1 ENSG00000197056 1706.094725 -0.722084754 2.37E-07 1.44E-05 CLIC3 ENSG00000169583 842.8495472 -1.234665536 2.44E-07 1.48E-05 DLEC1 ENSG00000008226 663.5870196 -0.891186966 2.49E-07 1.51E-05 HEBP1 ENSG00000013583 1993.489702 0.879057912 2.60E-07 1.57E-05 COTL1 ENSG00000103187 79073.74028 0.908637165 2.77E-07 1.65E-05 DCTN4 ENSG00000132912 5507.225355 0.759594452 2.79E-07 1.66E-05 NUSAP1 ENSG00000137804 774.1555267 0.750809919 2.81E-07 1.67E-05 PLEKHG3 ENSG00000126822 6795.473751 -0.936642433 2.83E-07 1.67E-05 TGM2 ENSG00000198959 576.0780048 1.608793292 2.87E-07 1.69E-05 WDR76 ENSG00000092470 752.2295074 -0.592405693 2.90E-07 1.71E-05 FSCN1 ENSG00000075618 304.128556 1.092579809 2.92E-07 1.71E-05 SDCBP ENSG00000137575 15101.4368 1.139649923 3.04E-07 1.76E-05 TTC16 ENSG00000167094 1283.629436 -1.288471732 3.13E-07 1.80E-05 SPON2 ENSG00000159674 7577.798104 -1.165104521 3.18E-07 1.83E-05 EVI5 ENSG00000067208 2018.205051 0.725764932 3.24E-07 1.85E-05 BCL10 ENSG00000142867 1957.826263 0.713568554 3.28E-07 1.87E-05 SOX4 ENSG00000124766 1035.227975 0.773292195 3.37E-07 1.91E-05 CD1D ENSG00000158473 6596.8656 1.016165442 3.42E-07 1.93E-05 SAPCD2 ENSG00000186193 577.8364362 1.218670374 3.43E-07 1.93E-05 FAM110C ENSG00000184731 85.28354957 -1.89252099 3.70E-07 2.06E-05 GMDS ENSG00000112699 1134.099078 0.626598543 3.76E-07 2.09E-05 MNT ENSG00000070444 5149.728786 0.739236882 3.78E-07 2.10E-05 TOM1 ENSG00000100284 9673.136451 1.058233944 3.87E-07 2.14E-05 MYL9 ENSG00000101335 1341.349861 1.788669865 3.90E-07 2.15E-05 EVA1B ENSG00000142694 321.8396455 1.187492169 3.90E-07 2.15E-05 TKT ENSG00000163931 50849.04775 0.931561003 3.95E-07 2.17E-05 ZNF467 ENSG00000181444 3338.89377 1.186569907 3.98E-07 2.18E-05 FBXO48 ENSG00000204923 516.009319 -0.848074429 4.06E-07 2.22E-05 SMIM3 ENSG00000256235 1580.345253 0.812306785 4.12E-07 2.24E-05

C1orf74 ENSG00000162757 1042.03803 -1.35686035 4.26E-07 2.31E-05 SLC15A3 ENSG00000110446 5168.329729 0.909084671 4.32E-07 2.34E-05 GPCPD1 ENSG00000125772 23696.6657 0.5383389 4.34E-07 2.34E-05 PXMP4 ENSG00000101417 707.8973702 -0.696375045 4.38E-07 2.36E-05 FAM83G ENSG00000188522 700.6821315 -0.933727029 4.41E-07 2.36E-05 CTSW ENSG00000172543 13355.97939 -1.073664749 4.47E-07 2.38E-05 MMP14 ENSG00000157227 846.3958243 1.183026485 4.47E-07 2.38E-05 MANEAL ENSG00000185090 114.8646174 -1.241002585 4.51E-07 2.40E-05 DNAH17 ENSG00000187775 2367.790273 0.947181734 4.54E-07 2.40E-05 ADAM22 ENSG00000008277 476.8763566 -0.848936097 4.73E-07 2.49E-05 ELL2 ENSG00000118985 2730.603633 1.12165723 4.76E-07 2.50E-05 PNPLA2 ENSG00000177666 10787.10077 0.784623907 4.84E-07 2.53E-05 CTD-2267D19.3 ENSG00000266208 152.1503071 1.29203878 4.88E-07 2.54E-05 ANKRD22 ENSG00000152766 543.030442 1.718592914 4.93E-07 2.55E-05 SMOX ENSG00000088826 939.547158 1.544789918 5.01E-07 2.59E-05 ARSB ENSG00000113273 2680.404119 0.671522971 5.11E-07 2.63E-05 HNRNPK ENSG00000165119 50364.02692 0.24905774 5.21E-07 2.68E-05 ZFAND3 ENSG00000156639 7621.834583 0.713323705 5.28E-07 2.70E-05 RP11-403I13.8 ENSG00000272419 3097.750868 -0.728251991 5.30E-07 2.70E-05 CNPY4 ENSG00000166997 1301.753564 -0.596733924 5.29E-07 2.70E-05 GATA1 ENSG00000102145 368.0038943 2.094246134 5.31E-07 2.70E-05 KIAA1958 ENSG00000165185 898.1533629 0.802478724 5.60E-07 2.83E-05 CYBB ENSG00000165168 84519.65951 0.895485601 5.74E-07 2.88E-05 PREPL ENSG00000138078 2380.584376 -0.864669619 5.83E-07 2.92E-05 COL8A2 ENSG00000171812 641.7910551 1.031310745 5.86E-07 2.93E-05 LRP1 ENSG00000123384 50329.76762 0.990372415 5.88E-07 2.93E-05 LRIF1 ENSG00000121931 867.5541085 -0.818589191 5.85E-07 2.93E-05 EPAS1 ENSG00000116016 477.6121809 1.24948613 5.99E-07 2.97E-05 DFFB ENSG00000169598 1894.032443 -0.648190119 6.03E-07 2.98E-05 SFPQ ENSG00000116560 26293.78927 0.80546739 6.16E-07 3.04E-05 HMOX1 ENSG00000100292 8186.947936 0.838114207 6.47E-07 3.17E-05 FCRL3 ENSG00000160856 6751.509292 -1.369043748 6.56E-07 3.20E-05 DDIT4 ENSG00000168209 14793.25774 1.805447724 6.56E-07 3.20E-05 ARL8A ENSG00000143862 5788.335057 0.761586185 6.64E-07 3.23E-05 FANCE ENSG00000112039 541.6809371 -0.734844836 6.81E-07 3.31E-05 MTSS1L ENSG00000132613 462.8905427 1.037798684 6.87E-07 3.33E-05 KIF3A ENSG00000131437 1086.616444 -0.856780309 6.91E-07 3.35E-05 CHCHD10 ENSG00000250479 1022.658998 0.907642881 6.93E-07 3.35E-05 EPB41L3 ENSG00000082397 4546.169123 1.155216575 7.08E-07 3.42E-05 SPIRE2 ENSG00000204991 387.3320942 -1.101312864 7.15E-07 3.43E-05 KLRF1 ENSG00000150045 4452.954295 -1.310864599 7.23E-07 3.47E-05 CD160 ENSG00000117281 1103.428885 -1.381632766 7.32E-07 3.48E-05 PLAUR ENSG00000011422 6956.571782 1.214564126 7.38E-07 3.49E-05 EIF1B ENSG00000114784 4419.958334 0.822642706 7.45E-07 3.52E-05 TMEM167B ENSG00000215717 8026.103115 0.813358291 7.52E-07 3.53E-05 ZNF623 ENSG00000183309 2458.430554 -0.816651303 7.52E-07 3.53E-05

DTHD1 ENSG00000197057 1856.085229 -1.320871878 7.64E-07 3.57E-05 TMEM158 ENSG00000249992 75.20086191 1.902086254 7.75E-07 3.60E-05 IRAK3 ENSG00000090376 10098.50168 1.354682783 7.82E-07 3.62E-05 GUSB ENSG00000169919 6164.780759 0.631363698 7.84E-07 3.62E-05 GRN ENSG00000030582 44371.83238 0.968461129 7.90E-07 3.64E-05 FZD5 ENSG00000163251 129.6684563 1.19804683 8.78E-07 3.99E-05 VIM ENSG00000026025 134133.4979 0.852594006 9.02E-07 4.07E-05 SDE2 ENSG00000143751 3211.170367 0.741190398 9.09E-07 4.08E-05 DSC2 ENSG00000134755 1703.482958 1.425966927 9.16E-07 4.11E-05 NVL ENSG00000143748 1841.166755 -0.433229004 9.30E-07 4.16E-05 HINFP ENSG00000172273 2238.932259 -0.381598338 9.34E-07 4.17E-05 SYTL3 ENSG00000164674 4814.652187 -0.605190419 9.34E-07 4.17E-05 MYO7A ENSG00000137474 902.515589 1.411182383 9.41E-07 4.19E-05 APOBEC3H ENSG00000100298 452.2986977 -0.993015443 9.41E-07 4.19E-05 LTA4H ENSG00000111144 33201.8335 0.848651008 9.50E-07 4.22E-05 DRAM1 ENSG00000136048 922.1831151 0.89145913 9.65E-07 4.28E-05 H1F0 ENSG00000189060 3387.703868 1.164886235 9.74E-07 4.31E-05 SCYL3 ENSG00000000457 2076.877552 -0.626921395 9.76E-07 4.31E-05 IGFBP3 ENSG00000146674 537.7681883 -1.381984272 9.85E-07 4.33E-05 RUFY4 ENSG00000188282 796.7452729 1.127240069 1.00E-06 4.40E-05 ARHGEF19 ENSG00000142632 1044.22232 -0.664645545 1.00E-06 4.40E-05 EIF4EBP1 ENSG00000187840 1930.717817 0.884215735 1.02E-06 4.46E-05 RAPGEF2 ENSG00000109756 4269.01853 0.739764615 1.03E-06 4.48E-05 MTRNR2L12 ENSG00000269028 94.21310536 1.698482706 1.04E-06 4.52E-05 EAF1 ENSG00000144597 1676.294772 1.058803469 1.04E-06 4.52E-05 FAM220A ENSG00000178397 859.9049422 -0.566126599 1.06E-06 4.58E-05 SYF2 ENSG00000117614 7363.558628 0.570274363 1.06E-06 4.59E-05 HSPA12B ENSG00000132622 263.0535226 1.300238295 1.06E-06 4.59E-05 TBXAS1 ENSG00000059377 14245.88651 0.881487932 1.10E-06 4.71E-05 C11orf63 ENSG00000109944 363.9645994 -0.881285752 1.10E-06 4.71E-05 IGFBP2 ENSG00000115457 75.67273795 2.075617693 1.10E-06 4.72E-05 RP11-80A15.1 ENSG00000258744 89.38557277 -0.960225778 1.14E-06 4.82E-05 GAS6 ENSG00000183087 1335.672146 1.265662561 1.16E-06 4.90E-05 ENO2 ENSG00000111674 3206.475941 -0.829397601 1.17E-06 4.94E-05 PEX11A ENSG00000166821 136.4689859 -1.096424891 1.17E-06 4.94E-05 NDUFAF5 ENSG00000101247 1158.21104 0.71403391 1.18E-06 4.98E-05 SMNDC1 ENSG00000119953 3612.789938 0.532381603 1.22E-06 5.10E-05 UBIAD1 ENSG00000120942 2044.84602 -0.465010809 1.22E-06 5.12E-05 WTAP ENSG00000146457 14022.48399 0.548554497 1.23E-06 5.14E-05 TRAF3IP3 ENSG00000009790 33103.99133 -0.552693595 1.23E-06 5.14E-05 MT-ND1 ENSG00000198888 257389.1467 0.910490584 1.23E-06 5.14E-05 FAM89A ENSG00000182118 309.3467528 1.585122216 1.24E-06 5.17E-05 ZNF501 ENSG00000186446 121.225273 -1.308638218 1.25E-06 5.18E-05 GUCD1 ENSG00000138867 7632.56243 0.579026532 1.26E-06 5.22E-05 SEC62 ENSG00000008952 5147.258859 0.724651518 1.26E-06 5.23E-05 CFD ENSG00000197766 4196.77769 0.980751149 1.28E-06 5.26E-05

CD63 ENSG00000135404 11786.89546 0.870959467 1.28E-06 5.26E-05 SLC7A7 ENSG00000155465 13706.52797 0.889158537 1.28E-06 5.26E-05 PELI2 ENSG00000139946 4452.116547 0.734218726 1.28E-06 5.27E-05 CNTLN ENSG00000044459 706.9095407 0.907163852 1.30E-06 5.32E-05 INSR ENSG00000171105 2012.567591 1.088048947 1.31E-06 5.34E-05 PKM ENSG00000067225 42425.70831 0.594568782 1.32E-06 5.35E-05 SLC39A11 ENSG00000133195 1863.826769 0.632005941 1.34E-06 5.43E-05 APP ENSG00000142192 11454.31281 0.666362867 1.36E-06 5.52E-05 TIMP1 ENSG00000102265 8593.634281 0.978534912 1.38E-06 5.57E-05 FMO4 ENSG00000076258 409.6735413 -0.502993775 1.39E-06 5.60E-05 FAM20A ENSG00000108950 283.7880324 1.77014985 1.39E-06 5.60E-05 SBK1 ENSG00000188322 2799.97278 -0.984154376 1.40E-06 5.61E-05 TNFRSF1B ENSG00000028137 57350.13199 0.808277234 1.40E-06 5.61E-05 WNT16 ENSG00000002745 159.5986075 -1.129066318 1.41E-06 5.61E-05 RNF175 ENSG00000145428 824.6586626 0.962423356 1.40E-06 5.61E-05 NUP210L ENSG00000143552 28.02211929 -1.319705966 1.41E-06 5.61E-05 NECTIN3 ENSG00000177707 100.5609867 -1.084426693 1.44E-06 5.71E-05 GAS7 ENSG00000007237 17145.55882 1.010715126 1.44E-06 5.71E-05 OTUD7B ENSG00000264522 703.0357919 -0.761261679 1.44E-06 5.71E-05 GAREM2 ENSG00000157833 155.109229 -0.835820925 1.48E-06 5.84E-05 SIL1 ENSG00000120725 1568.089585 0.649874496 1.52E-06 5.97E-05 TESC ENSG00000088992 2182.988102 1.321940114 1.52E-06 5.99E-05 S100A8 ENSG00000143546 86282.38505 1.181025019 1.55E-06 6.08E-05 CBX6 ENSG00000183741 5697.327849 0.78156095 1.55E-06 6.09E-05 SAMSN1 ENSG00000155307 9440.122312 1.289143691 1.56E-06 6.10E-05 LDHA ENSG00000134333 19776.87819 0.586226242 1.57E-06 6.12E-05 HES1 ENSG00000114315 74.86539379 1.532686387 1.60E-06 6.22E-05 GADD45A ENSG00000116717 1015.267797 0.982736331 1.61E-06 6.24E-05 NFIL3 ENSG00000165030 5528.114723 1.146531573 1.66E-06 6.42E-05 TNNI2 ENSG00000130598 610.3922334 0.910973218 1.69E-06 6.53E-05 ZMYND15 ENSG00000141497 479.3066595 1.088674555 1.70E-06 6.57E-05 GCSAM ENSG00000174500 929.3193539 -1.198692366 1.70E-06 6.58E-05 DEGS2 ENSG00000168350 55.95512252 -1.638373143 1.72E-06 6.61E-05 ADM ENSG00000148926 1789.164281 1.530331392 1.72E-06 6.61E-05 ZMYND10 ENSG00000004838 304.9304155 -1.138615624 1.72E-06 6.61E-05 METTL2A ENSG00000087995 492.4048408 -0.635358595 1.77E-06 6.76E-05 ZC3H14 ENSG00000100722 3273.269947 -0.384482169 1.77E-06 6.76E-05 IFNGR1 ENSG00000027697 18333.96399 0.961451087 1.79E-06 6.82E-05 DNAJC3 ENSG00000102580 6170.94434 0.606768999 1.83E-06 6.96E-05 SPG21 ENSG00000090487 8322.349262 0.502083706 1.84E-06 6.98E-05 FCGR1CP ENSG00000265531 632.3543718 1.600881471 1.86E-06 7.02E-05 MSRA ENSG00000175806 1075.220007 0.809542368 1.86E-06 7.02E-05 LAPTM4A ENSG00000068697 8461.781926 0.651876965 1.86E-06 7.02E-05 FTL ENSG00000087086 250165.763 0.859565999 1.86E-06 7.02E-05 OLFM2 ENSG00000105088 185.8386788 -1.301314893 1.91E-06 7.15E-05 GTF2F1 ENSG00000125651 6068.17837 0.624596928 1.96E-06 7.33E-05

AC006116.20 ENSG00000267710 64.64495855 -1.081399122 2.00E-06 7.43E-05 ERMP1 ENSG00000099219 1783.364079 -0.724969388 2.02E-06 7.47E-05 SGCB ENSG00000163069 441.7991861 -0.704750934 2.06E-06 7.61E-05 ATF4 ENSG00000128272 34653.26086 0.677287586 2.10E-06 7.76E-05 ATP6V0D1 ENSG00000159720 10988.14325 0.829293974 2.14E-06 7.86E-05 ASAH1 ENSG00000104763 20483.67735 0.906660242 2.18E-06 7.97E-05 PSMD7 ENSG00000103035 7146.301119 0.549724298 2.17E-06 7.97E-05 MICU1 ENSG00000107745 5201.476748 0.678188228 2.18E-06 7.97E-05 SLC35E4 ENSG00000100036 140.8588845 1.114851792 2.19E-06 8.00E-05 CREBRF ENSG00000164463 4930.629647 0.706869597 2.23E-06 8.12E-05 ZNF879 ENSG00000234284 308.5919669 -0.81716496 2.24E-06 8.13E-05 MTERF3 ENSG00000156469 1047.872056 -0.555050052 2.28E-06 8.26E-05 MAP1LC3B ENSG00000140941 3661.814193 0.943891244 2.31E-06 8.35E-05 LAP3 ENSG00000002549 10396.88 1.023184002 2.35E-06 8.46E-05 KLHL15 ENSG00000174010 2088.329016 0.892200998 2.35E-06 8.46E-05 ST8SIA6 ENSG00000148488 543.165188 -1.19047717 2.37E-06 8.50E-05 SYAP1 ENSG00000169895 4221.043227 0.801992758 2.39E-06 8.56E-05 LIPA ENSG00000107798 13843.80891 0.696959782 2.40E-06 8.59E-05 F3 ENSG00000117525 56.79087555 2.263655055 2.44E-06 8.72E-05 DDX23 ENSG00000174243 8097.203707 -0.415814465 2.45E-06 8.72E-05 BBS10 ENSG00000179941 692.5955118 -0.86692895 2.54E-06 9.00E-05 BMF ENSG00000104081 7174.844796 0.863101574 2.67E-06 9.38E-05 KLF9 ENSG00000119138 8418.59876 1.112800619 2.75E-06 9.59E-05 MYDGF ENSG00000074842 3490.739157 0.759952393 2.75E-06 9.59E-05 SIRPA ENSG00000198053 16261.6582 0.854706133 2.74E-06 9.59E-05 ARHGAP24 ENSG00000138639 1768.50316 1.091479174 2.75E-06 9.60E-05 TEF ENSG00000167074 698.2223478 -0.652669647 2.76E-06 9.60E-05 SYTL2 ENSG00000137501 3092.141234 -1.140257684 2.77E-06 9.63E-05 NDUFAF8 ENSG00000224877 546.1650254 0.827692655 2.82E-06 9.76E-05 ZFP3 ENSG00000180787 1192.732208 -0.961111685 2.85E-06 9.86E-05 ZNF473 ENSG00000142528 1047.022505 -0.669111322 2.88E-06 9.93E-05 RAB29 ENSG00000117280 6632.976157 -0.583466855 2.96E-06 0.000101813 USP21 ENSG00000143258 2254.872405 -0.447360961 2.97E-06 0.000101832 SMURF1 ENSG00000198742 3403.551271 0.715886202 2.97E-06 0.000101832 GPR171 ENSG00000174946 1214.314808 -1.092437165 3.00E-06 0.000102332 SPHK1 ENSG00000176170 673.447122 1.117849428 3.05E-06 0.000103925 DCP1B ENSG00000151065 1530.271702 -0.570627024 3.06E-06 0.000103966 C18orf25 ENSG00000152242 5321.483216 0.486922628 3.07E-06 0.000104443 RAG1 ENSG00000166349 71.83556188 -1.374017769 3.16E-06 0.000106991 LYL1 ENSG00000104903 2359.673662 1.231216657 3.19E-06 0.000107808 MSRB2 ENSG00000148450 1041.346234 0.799726149 3.22E-06 0.000108717 LYN ENSG00000254087 25689.8196 0.656686945 3.22E-06 0.000108725 KBTBD3 ENSG00000182359 334.9460405 -0.68265194 3.25E-06 0.000109267 RIOK3 ENSG00000101782 8150.518637 0.829774224 3.30E-06 0.000110516 GAA ENSG00000171298 13711.56631 0.838707219 3.34E-06 0.000111487 FGD6 ENSG00000180263 1486.213084 0.920537272 3.35E-06 0.000111598

KLF11 ENSG00000172059 7465.2572 0.878924255 3.40E-06 0.00011303 SAP30 ENSG00000164105 2312.605982 1.536066647 3.45E-06 0.000114326 SEMA4A ENSG00000196189 8704.822519 0.823960506 3.46E-06 0.000114443 USP6NL ENSG00000148429 2420.129997 0.754094035 3.50E-06 0.000115499 UBTD1 ENSG00000165886 627.5738099 1.006108501 3.51E-06 0.000115722 CETN3 ENSG00000153140 441.7199213 -0.930255257 3.53E-06 0.000116233 SERPINB1 ENSG00000021355 23049.63734 0.750997027 3.53E-06 0.000116294 DBR1 ENSG00000138231 1282.395587 -0.536491248 3.58E-06 0.000117785 ZNF181 ENSG00000197841 828.5854146 -0.942795439 3.60E-06 0.000117977 CUX1 ENSG00000257923 7779.810564 0.601336385 3.60E-06 0.000117977 XCL2 ENSG00000143185 490.584376 -1.256807339 3.72E-06 0.000121323 ZNF687 ENSG00000143373 4300.081128 0.556912151 3.74E-06 0.000121962 LIMA1 ENSG00000050405 1147.200305 -0.903348783 3.76E-06 0.000122594 GSTZ1 ENSG00000100577 559.2649374 0.727454069 3.79E-06 0.000123461 TMEM11 ENSG00000178307 1410.137737 0.805472048 3.81E-06 0.00012398 MMGT1 ENSG00000169446 3676.899841 0.458043287 3.87E-06 0.000125711 CFP ENSG00000126759 19021.65286 0.870606408 3.88E-06 0.000125711 HRH2 ENSG00000113749 7948.069927 0.924287103 3.90E-06 0.000126283 VAV2 ENSG00000160293 2043.81785 0.732345332 3.92E-06 0.000126585 ARL10 ENSG00000175414 1200.784466 -0.930696593 3.94E-06 0.000127309 CAMK2N1 ENSG00000162545 183.3583829 -1.206734158 3.95E-06 0.000127311 CDK20 ENSG00000156345 282.9234501 -0.743438668 3.99E-06 0.000128323 NOCT ENSG00000151014 356.635469 1.288202658 4.01E-06 0.000128768 MRPL44 ENSG00000135900 2596.822691 0.577089948 4.07E-06 0.000130063 CCDC124 ENSG00000007080 2528.886979 0.726513842 4.07E-06 0.000130063 CMKLR1 ENSG00000174600 2259.003453 -1.0978458 4.09E-06 0.000130352 CCDC85B ENSG00000175602 1132.727032 0.720802084 4.10E-06 0.000130381 TMEM183A ENSG00000163444 5977.09575 0.433559588 4.18E-06 0.000132777 DDO ENSG00000203797 184.8798127 1.091940437 4.19E-06 0.000132885 ZNF345 ENSG00000251247 922.780786 -0.731116114 4.21E-06 0.000133214 GAPDH ENSG00000111640 129152.6396 0.793704211 4.22E-06 0.000133504 RNF165 ENSG00000141622 565.809292 -1.225137694 4.25E-06 0.000134155 IFI27 ENSG00000165949 213.5405878 1.860639449 4.30E-06 0.000135538 ZYX ENSG00000159840 35288.39294 0.775807478 4.32E-06 0.000136061 GPR180 ENSG00000152749 1214.156059 -0.610536673 4.38E-06 0.00013754 ST14 ENSG00000149418 3029.947124 1.106987844 4.39E-06 0.000137709 CCRL2 ENSG00000121797 323.7957496 0.836363278 4.39E-06 0.000137709 TAF1A ENSG00000143498 816.0599612 -0.705953016 4.39E-06 0.000137709 SYT11 ENSG00000132718 3348.350111 -0.610993548 4.54E-06 0.000141672 CECR6 ENSG00000183307 777.598507 1.092416832 4.59E-06 0.000142983 ATP1A3 ENSG00000105409 649.618733 -0.864729759 4.62E-06 0.000143495 LAG3 ENSG00000089692 958.3882059 -0.962117912 4.65E-06 0.000144527 CLCN7 ENSG00000103249 13232.48243 0.633339422 4.74E-06 0.000146844 KIF5A ENSG00000155980 97.0285691 -1.139113997 4.79E-06 0.000148164 NRGN ENSG00000154146 8077.560961 1.228212388 4.81E-06 0.00014845 GALNT2 ENSG00000143641 5553.696448 0.587142856 4.85E-06 0.000149409

PGBD2 ENSG00000185220 699.8030325 -1.116045023 4.88E-06 0.000150194 NFIC ENSG00000141905 2721.896223 0.846181648 5.02E-06 0.000154231 RP3-461P17.10 ENSG00000269549 147.6989138 -0.970930351 5.18E-06 0.00015772 PCDH1 ENSG00000156453 277.2023631 -1.4426431 5.18E-06 0.00015772 SSFA2 ENSG00000138434 6193.898214 0.67370121 5.18E-06 0.00015772 CROT ENSG00000005469 1071.358897 -0.680521513 5.33E-06 0.000161324 BNIP3L ENSG00000104765 17429.68871 1.393496728 5.33E-06 0.000161324 QSOX1 ENSG00000116260 6980.800076 0.7049656 5.47E-06 0.000164667 GEMIN2 ENSG00000092208 351.4668526 -0.608992285 5.47E-06 0.000164667 PRDX6 ENSG00000117592 6415.892515 0.603215569 5.51E-06 0.000165504 BAG4 ENSG00000156735 1288.542016 0.809774015 5.52E-06 0.000165784 NIPAL4 ENSG00000172548 58.88450073 -1.215474797 5.60E-06 0.000167629 MORC4 ENSG00000133131 375.5992041 -0.739459064 5.63E-06 0.000168125 PLVAP ENSG00000130300 199.6842922 1.989646334 5.62E-06 0.000168125 FAM129B ENSG00000136830 4718.347318 0.825548988 5.69E-06 0.00016905 ANKZF1 ENSG00000163516 6406.330042 -0.340022225 5.71E-06 0.000169351 TBC1D10C ENSG00000175463 17117.16299 -0.556346872 5.73E-06 0.000169996 LLGL2 ENSG00000073350 3675.078345 -0.992168917 5.74E-06 0.000170125 OSBPL3 ENSG00000070882 4725.395534 -0.486836718 5.76E-06 0.00017027 AP2S1 ENSG00000042753 3808.179045 0.840357607 5.78E-06 0.000170584 FCGR1A ENSG00000150337 2739.055168 1.260558167 5.97E-06 0.00017594 LIN9 ENSG00000183814 293.4558062 -0.766743678 6.06E-06 0.000178083 KIAA0930 ENSG00000100364 12841.19879 0.769817907 6.09E-06 0.000178621 TAF13 ENSG00000197780 855.249629 0.760399052 6.17E-06 0.000180517 WDR70 ENSG00000082068 3106.433682 0.43522862 6.23E-06 0.000182208 AGFG2 ENSG00000106351 1087.544421 -1.00837783 6.26E-06 0.000182768 TTC30B ENSG00000196659 154.1539269 -0.907331991 6.27E-06 0.000182835 DLG4 ENSG00000132535 2387.77407 0.70855514 6.56E-06 0.000190384 MCMDC2 ENSG00000178460 52.35890449 -0.992372115 6.57E-06 0.000190449 ARRDC4 ENSG00000140450 3942.501519 0.87311124 6.63E-06 0.000191736 FAM72C ENSG00000263513 111.4635254 0.84621359 6.65E-06 0.000192083 FGD4 ENSG00000139132 3697.257099 1.144259733 6.80E-06 0.000196214 SCD5 ENSG00000145284 276.4924676 -1.197152715 6.80E-06 0.000196214 FAM183BP ENSG00000164556 174.4853316 1.425186422 6.87E-06 0.000197757 TFDP2 ENSG00000114126 3979.568098 -0.75955058 7.00E-06 0.000200889 TALDO1 ENSG00000177156 21861.67523 0.800169971 7.02E-06 0.00020129 SERBP1 ENSG00000142864 15380.75494 0.331819217 7.09E-06 0.000202937 SPET8 ENSG00000164402 1137.093289 -0.571075284 7.14E-06 0.000204074 HEXB ENSG00000049860 9232.474134 0.664479841 7.18E-06 0.000204908 EIF5A ENSG00000132507 10393.49721 0.539924477 7.22E-06 0.000205469 FCN1 ENSG00000085265 124252.9266 1.12476049 7.24E-06 0.000205904 STAT4 ENSG00000138378 9352.172388 -0.811249181 7.37E-06 0.00020823 SMYD2 ENSG00000143499 2614.036155 -0.488685537 7.38E-06 0.000208524 NCSTN ENSG00000162736 12744.94715 0.468102956 7.47E-06 0.000210488 IFNGR2 ENSG00000159128 13156.10235 0.763146693 7.54E-06 0.000212069 CCDC65 ENSG00000139537 849.8934163 -0.933277845 7.62E-06 0.000213658

SLC2A6 ENSG00000160326 4615.883027 0.899725783 7.66E-06 0.000214501 PKDCC ENSG00000162878 9.924450025 -2.127354097 7.72E-06 0.000216012 TNFAIP3 ENSG00000118503 32549.51136 1.20484476 7.73E-06 0.000216095 CAPG ENSG00000042493 10404.40709 0.840120203 7.81E-06 0.000217914 ARHGAP29 ENSG00000137962 174.958259 1.274213473 7.89E-06 0.000219466 OSBP2 ENSG00000184792 517.3336691 1.901155834 7.89E-06 0.000219466 SEC61B ENSG00000106803 3346.993592 0.59435928 7.90E-06 0.000219466 ZSWIM3 ENSG00000132801 256.2825286 -0.856439936 7.92E-06 0.000219578 ZBTB12 ENSG00000204366 108.073621 -0.907608029 7.99E-06 0.000220699 CAPRIN1 ENSG00000135387 13127.0022 0.306712445 7.99E-06 0.000220699 CCDC102A ENSG00000135736 492.6198777 -0.957632584 8.03E-06 0.000221491 GMPR ENSG00000137198 607.7336084 1.334206948 8.12E-06 0.00022346 WNT1 ENSG00000125084 188.7718012 -0.929879212 8.13E-06 0.00022346 TWNK ENSG00000107815 613.100942 -0.868428034 8.16E-06 0.000223876 MERTK ENSG00000153208 1238.145168 1.232063934 8.22E-06 0.00022516 ATG7 ENSG00000197548 3657.918827 0.662280346 8.23E-06 0.000225216 BAHCC1 ENSG00000266074 661.8647976 0.994884431 8.23E-06 0.000225217 ANKRD9 ENSG00000156381 514.2700678 1.655507429 8.28E-06 0.000226268 LARP4B ENSG00000107929 8189.727495 0.338452894 8.30E-06 0.000226695 ZFP82 ENSG00000181007 404.8408335 -0.966728576 8.44E-06 0.000229438 UBE2D3 ENSG00000109332 29488.76849 0.399362097 8.51E-06 0.000230898 RIN3 ENSG00000100599 16181.2999 0.776093283 8.62E-06 0.000233211 GADD45B ENSG00000099860 5496.942347 0.900633471 8.73E-06 0.000235962 MAP7D1 ENSG00000116871 12401.26814 0.656193775 8.84E-06 0.000238416 XPNPEP2 ENSG00000122121 186.8716211 -0.977721064 8.90E-06 0.000239195 RILPL2 ENSG00000150977 7838.832509 1.032937155 9.01E-06 0.00024162 RUSC2 ENSG00000198853 1455.225047 0.917191545 9.04E-06 0.000241913 NCOR2 ENSG00000196498 13015.02046 0.737119031 9.08E-06 0.00024284 PLSCR1 ENSG00000188313 7361.365339 0.975515909 9.09E-06 0.000242986 OXSM ENSG00000151093 379.8288797 -0.849286489 9.23E-06 0.000246305 CTCF ENSG00000102974 5931.76892 -0.453985607 9.31E-06 0.000247961 G6PD ENSG00000160211 8956.022104 0.747351915 9.36E-06 0.000249092 LRRC59 ENSG00000108829 4791.397792 0.728611685 9.51E-06 0.000252354 ZNF232 ENSG00000167840 384.0960571 -0.826044684 9.66E-06 0.000256022 EBF4 ENSG00000088881 454.9707856 -1.157259281 9.78E-06 0.000258903 ARHGDIA ENSG00000141522 18028.25568 0.675137233 9.82E-06 0.000259596 LSS ENSG00000160285 3446.268983 -0.725084043 9.93E-06 0.000262509 SLC25A13 ENSG00000004864 1897.459607 0.615293183 9.97E-06 0.000263151 MKS1 ENSG00000011143 628.3932405 -0.590541164 1.00E-05 0.000264102 RAB12 ENSG00000206418 6912.566486 0.643949116 1.01E-05 0.000264801 RASSF1 ENSG00000068028 12564.93119 -0.851365731 1.01E-05 0.000265023 KMT5A ENSG00000183955 3123.128427 0.479867069 1.01E-05 0.000265281 CCNB2 ENSG00000157456 206.7088036 1.098476224 1.02E-05 0.000266785 MSC ENSG00000178860 221.2653449 -0.924706792 1.02E-05 0.000267371 VRK2 ENSG00000028116 3100.013873 0.517887036 1.03E-05 0.000267736 MED9 ENSG00000141026 771.2684213 0.591900227 1.03E-05 0.000269599

IL10 ENSG00000136634 42.4453874 1.627482605 1.04E-05 0.000270013 MAP2K3 ENSG00000034152 8687.364286 1.029271516 1.04E-05 0.000271767 LDOC1L ENSG00000188636 2029.828873 -0.624226229 1.08E-05 0.000278959 TBC1D8 ENSG00000204634 4582.393944 0.847794444 1.09E-05 0.000281279 RPGRIP1L ENSG00000103494 194.752269 -0.860131949 1.09E-05 0.000281889 ZFP37 ENSG00000136866 146.7269901 -1.158728118 1.10E-05 0.000283688 PNO1 ENSG00000115946 1151.649517 0.510681849 1.10E-05 0.000284146 ANXA5 ENSG00000164111 21424.0401 0.645665614 1.11E-05 0.000285515 ELOVL6 ENSG00000170522 862.7479282 -0.835092278 1.11E-05 0.000286272 PPT1 ENSG00000131238 25338.91158 0.648331554 1.12E-05 0.000287673 C19orf44 ENSG00000105072 356.9720176 -0.628696313 1.13E-05 0.000289839 FBRS ENSG00000156860 10838.05909 0.67485585 1.14E-05 0.000291047 TNNT1 ENSG00000105048 547.3751753 1.79256584 1.17E-05 0.00029823 SERPINA1 ENSG00000197249 60684.67401 0.952269529 1.19E-05 0.000301436 ALOX5 ENSG00000012779 22871.61416 0.810394082 1.19E-05 0.000301976 UBE2E1 ENSG00000170142 6925.871701 0.551873424 1.20E-05 0.000303193 PDK4 ENSG00000004799 2333.218619 1.434926368 1.20E-05 0.000303359 ZNF792 ENSG00000180884 998.2107491 -0.758499266 1.23E-05 0.000309904 ZSCAN32 ENSG00000140987 1167.701274 -0.797740242 1.26E-05 0.000315389 CHRM5 ENSG00000184984 95.02027368 -1.030397547 1.26E-05 0.000315598 RIT1 ENSG00000143622 4757.005928 0.826635154 1.26E-05 0.000315761 RBM47 ENSG00000163694 4844.69491 0.779261228 1.26E-05 0.000315761 C15orf39 ENSG00000167173 8151.719226 1.010296888 1.26E-05 0.000315761 ACTB ENSG00000075624 329140.135 0.727806341 1.27E-05 0.000316596 PPIP5K1 ENSG00000168781 1417.195471 -0.426175123 1.27E-05 0.000317102 SCLT1 ENSG00000151466 4253.15425 0.735422776 1.27E-05 0.000317462 PSMC1 ENSG00000100764 6238.58829 0.459831392 1.29E-05 0.000320991 PHKB ENSG00000102893 6807.654948 0.304396362 1.31E-05 0.00032596 NEDD4L ENSG00000049759 523.0284 1.023648917 1.31E-05 0.000326263 SLC41A1 ENSG00000133065 2193.765029 -0.730809914 1.32E-05 0.000326836 ATF3 ENSG00000162772 500.3280717 1.135572843 1.32E-05 0.000326836 SNX3 ENSG00000112335 8844.610292 0.665787941 1.38E-05 0.000340154 ALDOA ENSG00000149925 39349.80925 0.73770076 1.38E-05 0.000340552 GNLY ENSG00000115523 25923.83028 -0.921334314 1.39E-05 0.000341498 IL13RA1 ENSG00000131724 10208.18945 0.86513972 1.39E-05 0.000341498 AFAP1L2 ENSG00000169129 239.7091733 -0.892705216 1.39E-05 0.000341498 SERTAD3 ENSG00000167565 2619.667198 0.804673227 1.39E-05 0.000341724 KLHL2 ENSG00000109466 4392.504479 0.827281502 1.43E-05 0.000349954 ITPK1 ENSG00000100605 10852.99879 0.627350469 1.43E-05 0.000350125 HP1BP3 ENSG00000127483 20998.20811 -0.390039105 1.44E-05 0.00035124 AC062017.1 ENSG00000222020 54.23278144 0.953053093 1.44E-05 0.00035124 TMEM238 ENSG00000233493 23.41880733 1.706509675 1.45E-05 0.00035296 MCTP1 ENSG00000175471 4486.408838 0.645570483 1.47E-05 0.000356369 ABCA3 ENSG00000167972 803.9219109 -0.72974371 1.50E-05 0.000361816 STK38 ENSG00000112079 31387.53539 -0.42368771 1.51E-05 0.00036258 CYB5R2 ENSG00000166394 95.38290512 1.332823987 1.51E-05 0.00036258

ZNF175 ENSG00000105497 905.0635969 -1.172900986 1.52E-05 0.000364354 FAM72D ENSG00000215784 143.6824995 0.734324191 1.52E-05 0.000365407 TRMT13 ENSG00000122435 3410.494111 -0.838291676 1.53E-05 0.000367147 IGF2BP2 ENSG00000073792 1421.226146 1.225755717 1.54E-05 0.000367947 KBTBD6 ENSG00000165572 375.490122 -0.792887583 1.54E-05 0.000367947 VIT ENSG00000205221 62.756 -1.834223451 1.54E-05 0.000367995 SRGN ENSG00000122862 76588.80987 0.756240848 1.57E-05 0.000372916 MRS2 ENSG00000124532 2853.50347 -0.51902862 1.57E-05 0.000374477 RHOQ ENSG00000119729 2488.87114 0.771348671 1.58E-05 0.000374947 ZNF124 ENSG00000196418 631.0815104 0.706752461 1.58E-05 0.000375607 C20orf27 ENSG00000101220 4026.479031 0.984502841 1.59E-05 0.000376216 NUCB1 ENSG00000104805 15120.33406 0.592682374 1.60E-05 0.000378497 MIS18A ENSG00000159055 370.5640331 -0.561710028 1.60E-05 0.00037934 KANK2 ENSG00000197256 133.0543441 1.201933918 1.62E-05 0.000381558 SELENOK ENSG00000113811 3106.043561 0.665167583 1.62E-05 0.000381558 CKAP2L ENSG00000169607 99.58409844 1.106741215 1.63E-05 0.000385259 RALGDS ENSG00000160271 10423.30621 -0.552815943 1.64E-05 0.000387359 BLVRB ENSG00000090013 4362.362139 1.307168513 1.66E-05 0.000390127 F5 ENSG00000198734 5044.378745 0.875270245 1.67E-05 0.000392709 ALAS1 ENSG00000023330 3294.087665 0.755857528 1.68E-05 0.000394937 SLC25A25 ENSG00000148339 2464.833702 0.628375509 1.68E-05 0.000395226 SPATA6 ENSG00000132122 823.2513311 0.858100366 1.70E-05 0.000398109 CHST13 ENSG00000180767 321.334172 1.129601416 1.70E-05 0.000398109 ACRC ENSG00000147174 724.1565212 -0.601315573 1.75E-05 0.000408109 EIF5AL1 ENSG00000253626 404.5536304 0.71896319 1.75E-05 0.00040954 ZP3 ENSG00000188372 354.3782258 0.872429527 1.76E-05 0.000410158 ADAMTS1 ENSG00000154734 285.5611742 -1.881462193 1.78E-05 0.000413757 SLCO4C1 ENSG00000173930 1769.416947 -0.979259989 1.79E-05 0.000415489 ST6GALNAC3 ENSG00000184005 527.3472766 1.043603842 1.79E-05 0.000415655 SP3 ENSG00000172845 10916.80083 0.582365221 1.80E-05 0.000415776 F12 ENSG00000131187 173.8223836 1.216856849 1.82E-05 0.000419965 C15orf40 ENSG00000169609 1249.287487 -0.43236765 1.85E-05 0.000426043 KANK3 ENSG00000186994 96.95779427 -1.101541159 1.85E-05 0.000426043 SLC6A8 ENSG00000130821 310.2591395 1.549922122 1.86E-05 0.000427623 CD93 ENSG00000125810 22974.37802 0.909742801 1.87E-05 0.000428578 CMTM3 ENSG00000140931 5860.553872 0.728451078 1.87E-05 0.000428768 HNRNPAB ENSG00000197451 6761.702059 0.356169141 1.88E-05 0.000431246 RENBP ENSG00000102032 2061.358924 0.703219717 1.88E-05 0.000431609 SNX2 ENSG00000205302 10475.15024 0.452427509 1.89E-05 0.000432416 RP1-122P22.4 ENSG00000268628 19.29556215 1.69846677 1.90E-05 0.000433278 ALDH3B1 ENSG00000006534 3910.571453 0.73265074 1.90E-05 0.000434978 ERC1 ENSG00000082805 1237.450087 0.801835628 1.91E-05 0.000435652 IRS2 ENSG00000185950 7085.836649 1.172410816 1.92E-05 0.000437085 GPRC5C ENSG00000170412 69.67411647 1.04089499 1.93E-05 0.000438738 P2RY1 ENSG00000169860 504.9135515 1.276899543 1.93E-05 0.000439067 FZD4 ENSG00000174804 53.922591 -1.232525348 1.94E-05 0.000440491

PDE4DIP ENSG00000178104 3383.730368 -0.735312201 1.94E-05 0.000441405 POMP ENSG00000132963 4636.452996 0.492481997 1.96E-05 0.000444094 IRF2BPL ENSG00000119669 2822.014793 0.853066674 1.96E-05 0.00044451 MAPRE1 ENSG00000101367 12788.44153 0.370926072 1.98E-05 0.000447677 DYSF ENSG00000135636 12870.58968 1.002033996 1.98E-05 0.000448727 ADPGK ENSG00000159322 15360.10574 0.39073035 2.00E-05 0.000451185 NCR3 ENSG00000204475 1053.696655 -1.218793603 2.02E-05 0.000454832 MIER2 ENSG00000105556 1685.997886 0.686850714 2.04E-05 0.000458357 DENND5A ENSG00000184014 13882.9443 0.574862169 2.07E-05 0.000463542 LRRC25 ENSG00000175489 11099.65889 0.770970373 2.12E-05 0.000473026 SLC25A6 ENSG00000169100 37500.97676 0.649554907 2.13E-05 0.000474226 PARP15 ENSG00000173200 13008.58495 -1.04538275 2.13E-05 0.000474427 ZMIZ1 ENSG00000108175 11834.50497 0.681398869 2.14E-05 0.000475734 MBLAC2 ENSG00000176055 710.1829233 -0.70303735 2.14E-05 0.000475734 DNAJA2 ENSG00000069345 4687.250983 0.472263225 2.15E-05 0.000475734 SIGIRR ENSG00000185187 10186.90034 -0.555730508 2.14E-05 0.000475734 CD3G ENSG00000160654 4760.520319 -1.127492791 2.19E-05 0.000484012 FAM46A ENSG00000112773 4673.528836 0.751534504 2.21E-05 0.000488156 PIP4K2C ENSG00000166908 2826.1836 -0.403137087 2.21E-05 0.000488921 CMTR2 ENSG00000180917 2245.13469 -0.803847278 2.22E-05 0.00048966 NPTXR ENSG00000221890 652.3442239 -1.103770158 2.22E-05 0.00048966 TSPOAP1 ENSG00000005379 5573.72386 -0.878661353 2.24E-05 0.000493293 AGPAT2 ENSG00000169692 2076.276842 0.82117938 2.24E-05 0.000493293 SAMD9 ENSG00000205413 5828.096453 -0.780859014 2.25E-05 0.000495378 NDUFB4 ENSG00000065518 1334.489972 0.720662373 2.27E-05 0.000498659 MGAT1 ENSG00000131446 21827.58491 0.733308502 2.27E-05 0.000500096 RNF152 ENSG00000176641 40.41408036 1.631171745 2.28E-05 0.000501867 ANKMY1 ENSG00000144504 3100.211903 -0.412676849 2.30E-05 0.000505076 PTPRE ENSG00000132334 26463.06671 0.94235023 2.31E-05 0.00050544 C1QB ENSG00000173369 614.1918153 1.460095556 2.32E-05 0.000508201 BMPR1A ENSG00000107779 589.5642587 -0.761565487 2.35E-05 0.000513259 PROSER2 ENSG00000148426 165.3435844 1.061687437 2.36E-05 0.000515053 SYNE1 ENSG00000131018 22104.46227 -0.705489594 2.36E-05 0.000515053 TPP1 ENSG00000166340 32121.35544 0.497071417 2.38E-05 0.000517438 TMEM68 ENSG00000167904 763.1611038 -0.516464005 2.39E-05 0.000518803 AMOT ENSG00000126016 279.1470636 -1.019641681 2.39E-05 0.000519905 AGGF1 ENSG00000164252 3429.296471 -0.497024623 2.40E-05 0.000521006 CCNI ENSG00000118816 29721.10037 0.380855983 2.43E-05 0.000525119 POMGNT1 ENSG00000085998 2436.25837 -0.461169316 2.49E-05 0.000535162 MAP3K8 ENSG00000107968 5149.583939 0.586976763 2.49E-05 0.000536197 TPM3 ENSG00000143549 30034.84509 0.432727004 2.52E-05 0.000540424 PCSK5 ENSG00000099139 1410.187057 0.726462757 2.54E-05 0.000543847 NEK2 ENSG00000117650 72.68109607 1.201472669 2.56E-05 0.000547359 IFT172 ENSG00000138002 1501.260404 -0.468591285 2.58E-05 0.000550195 ABCD1 ENSG00000101986 3210.493506 0.676979989 2.59E-05 0.000552283 ARSK ENSG00000164291 380.469308 -0.920662528 2.59E-05 0.000552684

ZNF829 ENSG00000185869 359.6752768 -0.95181209 2.60E-05 0.000552684 MRFAP1L1 ENSG00000178988 5231.479122 -0.628603751 2.60E-05 0.000553336 GID8 ENSG00000101193 6079.387701 0.398600459 2.61E-05 0.000554169 KIF19 ENSG00000196169 381.6955836 -1.116736321 2.62E-05 0.000554839 WASF1 ENSG00000112290 296.0314907 0.927356772 2.62E-05 0.000555235 SLC29A2 ENSG00000174669 599.9588587 -0.875691585 2.63E-05 0.000556999 MAML3 ENSG00000196782 2098.860334 0.845808345 2.65E-05 0.000558839 GPR84 ENSG00000139572 155.1470806 1.221861096 2.66E-05 0.000560501 MUM1 ENSG00000160953 2095.682793 -0.42973944 2.68E-05 0.000564598 LUC7L ENSG00000007392 6765.138691 -0.351011121 2.68E-05 0.00056486 TMEM132C ENSG00000181234 16.26316979 -1.951134073 2.70E-05 0.000567226 GAS1 ENSG00000180447 44.05021214 -1.583610703 2.70E-05 0.0005677 GSTO1 ENSG00000148834 5640.597281 0.686291084 2.73E-05 0.000571315 HJURP ENSG00000123485 226.8691982 1.190390135 2.73E-05 0.00057203 GTPBP4 ENSG00000107937 3131.555246 0.359288732 2.78E-05 0.000580727 PTP4A1 ENSG00000112245 8290.783197 0.519164477 2.79E-05 0.000581138 ASAP1 ENSG00000153317 9384.547422 0.526068475 2.83E-05 0.000589465 XK ENSG00000047597 324.5913567 1.527715444 2.84E-05 0.00058955 TBC1D19 ENSG00000109680 293.3686559 -0.743872799 2.85E-05 0.000591075 ERLIN2 ENSG00000147475 2648.280239 0.459632272 2.87E-05 0.000595106 DTX4 ENSG00000110042 6694.110831 0.858344401 2.88E-05 0.000597327 CBX3 ENSG00000122565 5456.756539 0.387614836 2.94E-05 0.000607773 CRAT ENSG00000095321 1634.576127 0.626052817 2.97E-05 0.000613036 PPP1R1A ENSG00000135447 60.15081383 1.036710031 2.97E-05 0.00061328 COX5B ENSG00000135940 4012.335388 0.624297245 3.01E-05 0.000619224 CNR1 ENSG00000118432 48.56845356 -1.352471688 3.01E-05 0.000619445 CHIC2 ENSG00000109220 2421.570739 0.636118627 3.02E-05 0.000621124 USF2 ENSG00000105698 12315.32277 0.484525771 3.03E-05 0.000621818 LPCAT3 ENSG00000111684 2818.298085 0.443097745 3.03E-05 0.000621818 THBD ENSG00000178726 1201.224962 1.125627492 3.08E-05 0.000630494 AMFR ENSG00000159461 4522.582345 0.468723825 3.12E-05 0.000637419 IQSEC2 ENSG00000124313 1557.904644 0.693202181 3.18E-05 0.000646993 TMSB10 ENSG00000034510 106463.6434 0.732933026 3.18E-05 0.000647706 BBS7 ENSG00000138686 829.4748709 -0.63181495 3.19E-05 0.000647789 SCARB2 ENSG00000138760 7818.956087 0.611286208 3.24E-05 0.000656682 LLGL1 ENSG00000131899 2224.66951 -0.473228197 3.24E-05 0.000657192 NTSR1 ENSG00000101188 615.6611048 1.302274183 3.24E-05 0.000657192 TNFAIP8L1 ENSG00000185361 1693.452182 0.448057438 3.26E-05 0.000660188 PSTPIP2 ENSG00000152229 7807.484669 0.719762594 3.27E-05 0.000661163 ACTL6A ENSG00000136518 1948.277347 -0.470989119 3.28E-05 0.000662472 EPB41L4A ENSG00000129595 250.7415537 -1.20209184 3.30E-05 0.000666284 OLFML2B ENSG00000162745 137.0443193 1.063966737 3.33E-05 0.000669589 ACTG1 ENSG00000184009 64634.70295 0.645459976 3.33E-05 0.000669589 NUDT16 ENSG00000198585 2096.714396 0.775907415 3.33E-05 0.000669589 SLC31A2 ENSG00000136867 1949.469228 0.801339069 3.33E-05 0.000669685 SPPL3 ENSG00000157837 2723.034085 0.441764939 3.34E-05 0.000670814

UBE2C ENSG00000175063 168.3620383 1.142489485 3.40E-05 0.000680589 COPS2 ENSG00000166200 5395.400871 0.567139604 3.43E-05 0.000685841 EFNA5 ENSG00000184349 69.8600847 -1.479842619 3.43E-05 0.000686304 SLC39A14 ENSG00000104635 491.9865111 -0.801450365 3.47E-05 0.000692426 MT-ND3 ENSG00000198840 80743.70213 0.686893602 3.50E-05 0.000697891 RNASE2 ENSG00000169385 3447.261414 1.188420955 3.52E-05 0.000700542 ATP6AP1 ENSG00000071553 10012.42344 0.689018486 3.56E-05 0.00070566 DIAPH3 ENSG00000139734 39.90828356 1.481996608 3.55E-05 0.00070566 UBXN6 ENSG00000167671 6364.177901 1.030892545 3.60E-05 0.000711795 BLVRA ENSG00000106605 4506.430436 0.75270839 3.61E-05 0.000713736 SCAF4 ENSG00000156304 7145.680583 0.491800998 3.62E-05 0.000714921 TMEM99 ENSG00000167920 123.0900751 -1.134978464 3.64E-05 0.000719081 CTNNAL1 ENSG00000119326 259.6001703 1.232004044 3.65E-05 0.000719245 SART1 ENSG00000175467 8785.93691 0.502030526 3.66E-05 0.00072051 DZANK1 ENSG00000089091 340.7491684 -0.543569564 3.66E-05 0.000721094 ZNF572 ENSG00000180938 95.03803059 -0.989453114 3.67E-05 0.0007218 SLC11A2 ENSG00000110911 3867.354471 0.540679941 3.71E-05 0.000728954 FABP5 ENSG00000164687 632.8281197 0.830536641 3.72E-05 0.000731133 C19orf25 ENSG00000119559 1015.761677 -0.611796058 3.73E-05 0.000731292 SPATA32 ENSG00000184361 35.07852523 -1.091990481 3.74E-05 0.000733064 SPATA2L ENSG00000158792 572.3081615 0.664741304 3.76E-05 0.000737811 LPCAT4 ENSG00000176454 2881.159117 -0.55032145 3.79E-05 0.000741737 LAIR2 ENSG00000167618 607.833195 -1.414358445 3.83E-05 0.000747493 RGS1 ENSG00000090104 2085.443672 1.149738112 3.84E-05 0.000749187 RHEBL1 ENSG00000167550 194.0291262 -0.740274506 3.86E-05 0.000752547 LYAR ENSG00000145220 3310.202206 -0.462516318 3.88E-05 0.000754703 DTYMK ENSG00000168393 1522.663905 -0.499709542 3.96E-05 0.000768378 RTN4 ENSG00000115310 14816.74475 0.52045146 3.97E-05 0.000768771 PDGFC ENSG00000145431 460.2908355 0.779167534 3.98E-05 0.000769662 MRPS31 ENSG00000102738 1689.60665 -0.686575626 4.01E-05 0.000774773 NDUFB10 ENSG00000140990 2682.242998 0.540619968 4.09E-05 0.00078709 IL27 ENSG00000197272 90.2883932 1.237092103 4.10E-05 0.000787827 TTC9B ENSG00000174521 43.10972574 1.268805502 4.15E-05 0.000795662 ZNF91 ENSG00000167232 2373.232459 -0.770606632 4.18E-05 0.000801034 AC243756.1 ENSG00000270339 32.89384268 -1.527016366 4.19E-05 0.000803508 CCDC149 ENSG00000181982 1742.6005 0.594897298 4.25E-05 0.000812404 SUMO3 ENSG00000184900 6901.652984 0.850919553 4.26E-05 0.000813752 FBN2 ENSG00000138829 1690.521649 0.934484818 4.27E-05 0.000814844 SLC1A7 ENSG00000162383 542.6750614 -1.500891038 4.28E-05 0.000815991 TNS3 ENSG00000136205 3835.471236 0.683913367 4.28E-05 0.000816476 U2AF1 ENSG00000160201 8606.424264 0.75688195 4.28E-05 0.000816476 PALB2 ENSG00000083093 1024.81892 -0.399028887 4.31E-05 0.000819378 OS9 ENSG00000135506 27243.10285 0.541940613 4.31E-05 0.000819523 YPEL5 ENSG00000119801 18212.01316 0.522580497 4.32E-05 0.000821481 S100A6 ENSG00000197956 21271.40333 0.758956841 4.35E-05 0.000825425 RAPH1 ENSG00000173166 90.84843241 0.938641775 4.41E-05 0.000834363

GIMAP7 ENSG00000179144 8120.38422 -1.061520893 4.42E-05 0.000836224 MEF2D ENSG00000116604 11004.92103 0.684071193 4.43E-05 0.000838055 HK2 ENSG00000159399 6987.177648 0.736526435 4.46E-05 0.000842003 OSER1 ENSG00000132823 8251.50746 0.596619739 4.47E-05 0.000842219 PBK ENSG00000168078 44.90699509 1.500657017 4.47E-05 0.000842219 CCDC136 ENSG00000128596 789.445444 -0.837435115 4.49E-05 0.000844795 PCBP1 ENSG00000169564 31969.746 0.558859521 4.56E-05 0.000856045 USP54 ENSG00000166348 626.574794 -0.539711956 4.57E-05 0.000856045 PIGA ENSG00000165195 2658.357115 0.637486471 4.59E-05 0.000858925 CDKN2C ENSG00000123080 544.8439731 0.718752571 4.64E-05 0.000865272 BNIP2 ENSG00000140299 10205.86771 0.567332244 4.63E-05 0.000865272 CYB5R3 ENSG00000100243 6434.843974 0.57139205 4.65E-05 0.00086692 HCFC1R1 ENSG00000103145 541.4168626 0.577355756 4.65E-05 0.00086692 MTHFR ENSG00000177000 8795.478162 0.543056315 4.67E-05 0.00086893 NT5C2 ENSG00000076685 11495.89703 0.639430981 4.67E-05 0.00086893 RNF11 ENSG00000123091 5686.321136 1.132192784 4.68E-05 0.000870143 CLASRP ENSG00000104859 9909.373613 0.458312063 4.70E-05 0.000872345 TMEM223 ENSG00000168569 664.666278 -0.478420398 4.71E-05 0.000874494 RAB27B ENSG00000041353 1123.831928 -0.916828359 4.72E-05 0.000875298 MVK ENSG00000110921 674.8975469 -0.616116764 4.73E-05 0.000876985 FGR ENSG00000000938 71368.5614 0.643522957 4.79E-05 0.000885642 MAGI2 ENSG00000187391 45.59150199 -0.929553762 4.81E-05 0.000888966 TP53I3 ENSG00000115129 895.1835247 0.76996802 4.83E-05 0.000891268 IMPA2 ENSG00000141401 2548.991845 0.763342218 4.85E-05 0.000892899 GUCY2C ENSG00000070019 553.4883288 0.922609907 4.86E-05 0.000893474 AGTRAP ENSG00000177674 4928.384967 0.644847731 4.86E-05 0.000893474 KIAA2022 ENSG00000050030 58.66591009 -1.046243605 4.90E-05 0.00090025 PGAM4 ENSG00000226784 227.1244983 0.757690325 4.91E-05 0.000902846 TIGAR ENSG00000078237 1132.229506 0.504982345 4.96E-05 0.000909792 VPS50 ENSG00000004766 2086.888347 -0.508843579 5.05E-05 0.000924843 ZNF691 ENSG00000164011 435.0257653 -0.816265338 5.06E-05 0.000926134 SYNE2 ENSG00000054654 22683.37847 -0.779093577 5.09E-05 0.000929956 CMTM6 ENSG00000091317 18020.48286 0.564483781 5.12E-05 0.000933791 SAT2 ENSG00000141504 2159.53791 0.614440342 5.12E-05 0.000934603 SLC29A1 ENSG00000112759 1181.184666 1.000015071 5.14E-05 0.000937616 PARS2 ENSG00000162396 117.9096531 -1.389817514 5.17E-05 0.000939881 PPIAL4E ENSG00000271567 8.62054507 -1.704908836 5.17E-05 0.000940189 NAB2 ENSG00000166886 1124.677977 0.761259931 5.18E-05 0.000940561 HBP1 ENSG00000105856 6820.947678 0.655699159 5.20E-05 0.000942624 REEP4 ENSG00000168476 2468.255564 0.759352207 5.20E-05 0.000942624 DUSP4 ENSG00000120875 461.2209966 1.375808699 5.22E-05 0.000944848 MYL5 ENSG00000215375 670.1520819 0.6211168 5.26E-05 0.000948019 MKRN1 ENSG00000133606 14802.50263 0.624068672 5.36E-05 0.000964695 XCL1 ENSG00000143184 248.2417753 -1.29197576 5.38E-05 0.000965962 ELP6 ENSG00000163832 1335.285519 -0.429336347 5.43E-05 0.000973086 PTPN1 ENSG00000196396 9483.739497 0.51982106 5.45E-05 0.0009772

IL17RC ENSG00000163702 440.4595536 0.71835943 5.49E-05 0.000983029 IL16 ENSG00000172349 16700.88176 -0.531559661 5.51E-05 0.000984484 CCIN ENSG00000185972 42.84075848 1.382653952 5.52E-05 0.000986306 SOCS6 ENSG00000170677 626.2890186 0.859272405 5.52E-05 0.000986306 CLCN5 ENSG00000171365 1655.760824 0.699059982 5.58E-05 0.000993192 TDRD9 ENSG00000156414 996.6878466 0.914882656 5.63E-05 0.001001876 ANO10 ENSG00000160746 1218.064348 0.613446636 5.65E-05 0.00100321 ICOSLG ENSG00000160223 1680.86369 1.013271171 5.70E-05 0.001010571 GMNN ENSG00000112312 604.1948032 0.754131895 5.73E-05 0.001013604 B3GAT1 ENSG00000109956 1620.102652 -1.276901883 5.73E-05 0.001014366 UAP1L1 ENSG00000197355 3868.816212 0.762057953 5.78E-05 0.001020792 C1orf54 ENSG00000118292 341.3193503 0.50543576 5.80E-05 0.001022958 DAXX ENSG00000204209 4170.49056 -0.459587576 5.84E-05 0.001029513 GPR55 ENSG00000135898 663.3761493 -0.861548555 5.90E-05 0.001037612 TUBD1 ENSG00000108423 594.1278795 -0.597374839 5.94E-05 0.001045647 WARS ENSG00000140105 25273.87984 0.87903981 5.96E-05 0.001047569 C21orf140 ENSG00000222018 46.24465244 -0.854893422 6.00E-05 0.001053612 OSBPL7 ENSG00000006025 3854.201288 -0.505032751 6.07E-05 0.001064291 PLEKHM2 ENSG00000116786 8613.642247 0.520999744 6.11E-05 0.001070769 UBXN11 ENSG00000158062 17387.86216 0.765821625 6.16E-05 0.001078058 TMEM38A ENSG00000072954 314.1387732 0.806795278 6.17E-05 0.001079683 TKTL1 ENSG00000007350 473.5783389 -1.362292317 6.20E-05 0.00108478 TNIP3 ENSG00000050730 89.49737852 -1.442785709 6.28E-05 0.001097868 HSP90B1 ENSG00000166598 41049.16841 0.37363628 6.32E-05 0.001102639 FN1 ENSG00000115414 281.236981 1.131667971 6.34E-05 0.001106637 TRPV4 ENSG00000111199 189.5802448 1.159242688 6.35E-05 0.001107626 TMEM177 ENSG00000144120 462.5801464 -0.943778212 6.38E-05 0.00111136 CSRNP1 ENSG00000144655 5840.418632 1.133429988 6.39E-05 0.001112404 ARVCF ENSG00000099889 492.4933049 -0.979106514 6.42E-05 0.001117456 ENO1 ENSG00000074800 51709.39618 0.560490582 6.47E-05 0.001123573 ELP3 ENSG00000134014 2480.061804 -0.470922988 6.48E-05 0.001125017 EIF5A2 ENSG00000163577 562.4268383 -0.685953708 6.53E-05 0.001130967 OR6N1 ENSG00000197403 485.5118794 -1.183410203 6.54E-05 0.001131367 IDH3G ENSG00000067829 5712.828704 0.605762587 6.61E-05 0.00114107 PAFAH2 ENSG00000158006 2557.45024 -0.570005109 6.64E-05 0.001144584 EAPP ENSG00000129518 3676.917964 0.404981461 6.66E-05 0.001147746 MTFMT ENSG00000103707 678.2491803 -0.657624051 6.69E-05 0.001150011 CEP72 ENSG00000112877 558.1927165 -0.620800083 6.68E-05 0.001150011 NCF1 ENSG00000158517 19115.48124 0.951378605 6.74E-05 0.001157192 ZNF594 ENSG00000180626 673.9336383 -0.799621422 6.74E-05 0.001157192 THNSL1 ENSG00000185875 235.8025026 -1.038157606 6.75E-05 0.001158332 OTUD1 ENSG00000165312 3452.710454 0.506042412 6.76E-05 0.00115867 PRMT3 ENSG00000185238 1662.399944 0.487184527 6.76E-05 0.00115867 GRIN2C ENSG00000161509 221.7895408 1.148487546 6.81E-05 0.001165682 XBP1 ENSG00000100219 9864.604139 0.57473949 6.81E-05 0.001165682 NOTCH3 ENSG00000074181 61.91418127 1.177563818 6.83E-05 0.001167846

ADGRA2 ENSG00000020181 824.3115338 0.703790184 6.90E-05 0.00117738 STK32B ENSG00000152953 136.5666415 0.961705941 6.95E-05 0.001185066 CLTC ENSG00000141367 15475.14405 0.435459742 7.08E-05 0.001205835 TXNDC2 ENSG00000168454 20.74539038 1.679028812 7.11E-05 0.001209794 KDELC2 ENSG00000178202 1047.056436 -0.591798181 7.14E-05 0.001214077 BRAT1 ENSG00000106009 6361.618612 0.583171623 7.22E-05 0.001226514 RUNDC3A ENSG00000108309 77.96215479 1.776643854 7.23E-05 0.001226827 MTCH1 ENSG00000137409 16457.24081 0.510174105 7.23E-05 0.001226827 EDC3 ENSG00000179151 1921.761933 -0.458780079 7.24E-05 0.001227003 MARVELD1 ENSG00000155254 1550.788775 0.920352928 7.25E-05 0.001228173 RAB9B ENSG00000123570 59.606398 -1.022543124 7.29E-05 0.001233519 MUL1 ENSG00000090432 1613.61552 0.416679124 7.29E-05 0.001233519 RRBP1 ENSG00000125844 6084.994972 0.619594548 7.32E-05 0.001237271 CUL3 ENSG00000036257 7439.639903 0.400365142 7.38E-05 0.001246591 HK3 ENSG00000160883 19144.47628 0.781724979 7.47E-05 0.001259316 LAX1 ENSG00000122188 1547.937215 -1.172633838 7.49E-05 0.00126246 TFDP1 ENSG00000198176 4276.477005 0.795400628 7.58E-05 0.001276835 NT5DC2 ENSG00000168268 647.5321277 0.812739034 7.66E-05 0.001286554 AVPI1 ENSG00000119986 241.4809038 1.153222013 7.78E-05 0.001304122 TXNL1 ENSG00000091164 4857.102993 0.432618432 7.81E-05 0.001307554 GGPS1 ENSG00000152904 2279.942021 -0.541938558 7.84E-05 0.001312758 ZEB2 ENSG00000169554 25701.6949 0.732180483 7.85E-05 0.001312758 HADHA ENSG00000084754 21848.65095 0.479890816 7.85E-05 0.001313031 PHC1 ENSG00000111752 4356.715272 -0.732365497 7.88E-05 0.001317781 CCHCR1 ENSG00000204536 1335.017876 -0.448840157 7.98E-05 0.001331564 UQCC1 ENSG00000101019 2963.467417 -0.635363014 8.04E-05 0.001340848 KRBOX4 ENSG00000147121 1157.591156 -0.629063564 8.08E-05 0.001345361 SPOCK1 ENSG00000152377 194.976942 0.847774001 8.09E-05 0.001347524 ACYP1 ENSG00000119640 874.8805042 -0.725861671 8.10E-05 0.001348596 FAM214B ENSG00000005238 4718.738646 0.852397849 8.18E-05 0.00135896 NCAPG ENSG00000109805 223.1167606 0.870293324 8.21E-05 0.001363348 CDCA2 ENSG00000184661 89.26958558 1.121689012 8.26E-05 0.001370766 CTSH ENSG00000103811 12480.442 0.622811889 8.33E-05 0.001380912 ZNF202 ENSG00000166261 2054.917676 -0.45322675 8.38E-05 0.001386403 MAD2L1BP ENSG00000124688 1462.567556 0.66854578 8.37E-05 0.001386403 LCK ENSG00000182866 17099.27143 -0.807809955 8.43E-05 0.001394051 PTPN2 ENSG00000175354 6674.427634 0.340760614 8.50E-05 0.001402844 BAG1 ENSG00000107262 4450.481925 0.877090345 8.61E-05 0.001418798 CDT1 ENSG00000167513 210.6879177 1.032661881 8.63E-05 0.001420908 C14orf2 ENSG00000156411 3550.282352 0.554380853 8.75E-05 0.001439161 RRAGD ENSG00000025039 1273.966398 0.757675789 8.79E-05 0.001445089 IL1RN ENSG00000136689 3104.206703 1.365803261 8.91E-05 0.001461943 FAM105A ENSG00000145569 4125.567694 0.420731781 8.95E-05 0.001467639 ZFP62 ENSG00000196670 1766.326916 -0.773119753 8.96E-05 0.001468267 PGAM1 ENSG00000171314 12818.10396 0.483784548 9.02E-05 0.001475192 CDK1 ENSG00000170312 191.209775 0.865641527 9.05E-05 0.001478054

CEP126 ENSG00000110318 354.350904 -0.997457498 9.05E-05 0.001478054 TRUB1 ENSG00000165832 914.3708168 -0.585422134 9.05E-05 0.001478054 RNF34 ENSG00000170633 2268.776101 -0.489817059 9.12E-05 0.001487391 CLU ENSG00000120885 4400.213172 1.168012201 9.13E-05 0.001488876 XRN2 ENSG00000088930 13666.13213 0.400934894 9.19E-05 0.001496117 CCR8 ENSG00000179934 35.3180099 -1.332638942 9.22E-05 0.00150093 FOSL2 ENSG00000075426 5869.21698 1.137637457 9.24E-05 0.001503217 SMIM1 ENSG00000235169 44.90149806 1.539828557 9.25E-05 0.001503502 MLF1 ENSG00000178053 72.25705541 -1.097101535 9.28E-05 0.001506736 GZMK ENSG00000113088 4607.905704 -1.146326915 9.27E-05 0.001506736 C14orf28 ENSG00000179476 429.6719594 -0.611208376 9.32E-05 0.001512692 GMFB ENSG00000197045 3418.193359 0.898030161 9.38E-05 0.001519815 ABCB1 ENSG00000085563 2007.969546 -0.864947017 9.41E-05 0.001524377 CSGALNACT2 ENSG00000169826 19762.77153 0.784065875 9.45E-05 0.001529222 RBM12B ENSG00000183808 1641.88587 -0.72170914 9.51E-05 0.00153523 AKAP7 ENSG00000118507 1060.759983 0.416413766 9.59E-05 0.001547144 ALCAM ENSG00000170017 2552.350902 0.575248701 9.67E-05 0.001556529 WDFY2 ENSG00000139668 4029.803179 0.536420102 9.68E-05 0.001557078 FAM72B ENSG00000188610 188.6172142 0.817620723 9.70E-05 0.001559177 HDHD3 ENSG00000119431 783.5442034 -0.70582367 9.86E-05 0.001581244 ATP6V0B ENSG00000117410 7753.679474 0.660250972 9.99E-05 0.001596031 TSC22D3 ENSG00000157514 62747.83624 1.035781624 9.98E-05 0.001596031 MCM8 ENSG00000125885 799.9612256 -0.883814344 0.000100281 0.001600486 AREG ENSG00000109321 1301.439736 1.701353521 0.00010176 0.001619119 CYP20A1 ENSG00000119004 2213.484193 -0.538867168 0.000102049 0.001622054 SNRPF ENSG00000139343 1854.653408 0.500818583 0.000102948 0.001633197 NCAPD3 ENSG00000151503 2593.027458 -0.481154405 0.000103517 0.001641209 COX7B ENSG00000131174 3616.822358 0.538197221 0.000104989 0.001662006 GRB10 ENSG00000106070 1012.815777 0.642473454 0.000105264 0.001665512 UTF1 ENSG00000171794 19.18981598 1.851602799 0.000105364 0.001666247 HSBP1 ENSG00000230989 1985.364609 0.551152255 0.000105509 0.001667178 PLS1 ENSG00000120756 96.09113859 -0.934625294 0.000106077 0.00167359 ILKAP ENSG00000132323 5559.521345 0.399011992 0.000106097 0.00167359 JAG1 ENSG00000101384 507.1532013 0.792182507 0.000106521 0.001679438 CDC20 ENSG00000117399 184.386119 1.198321422 0.000106786 0.001681059 AGAP3 ENSG00000133612 3760.241733 0.543664319 0.00010685 0.001681209 DHX57 ENSG00000163214 3003.342705 0.377944386 0.000107008 0.001682002 TOR2A ENSG00000160404 2003.096355 0.545422585 0.000107091 0.001682462 MATN1 ENSG00000162510 86.50068282 1.229203117 0.000107355 0.001685755 DPYD ENSG00000188641 11786.40066 0.602092476 0.000107498 0.001687145 SH2D1B ENSG00000198574 2696.963143 -1.067548698 0.000107874 0.001692191 FAM131B ENSG00000159784 256.058595 -0.909707046 0.000107943 0.001692423 CRISPLD2 ENSG00000103196 2667.608874 0.903141532 0.000108823 0.001703657 SEC13 ENSG00000157020 4518.400816 0.372630814 0.000108958 0.001704911 DIEXF ENSG00000117597 1779.242851 -0.588244423 0.000109262 0.00170795 HADHB ENSG00000138029 10385.10753 0.476051637 0.000110466 0.001725038

CDAN1 ENSG00000140326 1798.969025 -0.352331357 0.00011117 0.001735164 FBXO7 ENSG00000100225 15242.96817 0.730117204 0.000111895 0.001742124 ERH ENSG00000100632 5964.35101 0.390457795 0.000111862 0.001742124 COL4A3 ENSG00000169031 399.6889257 -1.075082555 0.00011228 0.001745487 PRKAG2 ENSG00000106617 6188.47851 0.646364885 0.000113555 0.001762675 GNAO1 ENSG00000087258 392.6462825 -0.816752908 0.000113835 0.001766147 CCDC121 ENSG00000176714 72.73841432 -1.410466873 0.000114413 0.001773349 SERPINH1 ENSG00000149257 445.2907929 -0.513838678 0.000115312 0.001784615 ABLIM2 ENSG00000163995 82.89218484 -0.731081498 0.000115724 0.001788334 NFKBIB ENSG00000104825 2652.043696 0.559130101 0.000116539 0.001800021 SUPT20H ENSG00000102710 5124.48639 -0.354819559 0.000116834 0.001803692 USP32 ENSG00000170832 6917.997596 0.618453659 0.000117611 0.001814788 RELA ENSG00000173039 8060.463807 0.529532672 0.000117781 0.001816514 NAP1L2 ENSG00000186462 282.8462931 -1.018239379 0.000117896 0.001817391 ITPRIP ENSG00000148841 6730.413979 0.994337849 0.000118284 0.001821431 LRFN2 ENSG00000156564 33.55433501 -1.55608651 0.000118392 0.001821431 TRIM72 ENSG00000177238 15.77921225 1.797940592 0.000119232 0.001830729 ZKSCAN4 ENSG00000187626 488.6511178 -0.694642171 0.00011978 0.001837332 CARMIL3 ENSG00000186648 796.2624864 -0.943452326 0.000119906 0.001838369 SMAD1 ENSG00000170365 388.6113193 0.912298036 0.000120778 0.001849004 PAQR7 ENSG00000182749 1172.593203 0.609747153 0.000121051 0.00185045 SNCA ENSG00000145335 2172.282847 1.630064632 0.000122617 0.001872551 RNPEP ENSG00000176393 7648.804829 0.535094309 0.000122806 0.00187361 TOR4A ENSG00000198113 1765.046888 0.823025219 0.000123036 0.001875274 TKTL2 ENSG00000151005 43.99443435 1.759503932 0.000123968 0.001886719 ATG3 ENSG00000144848 9646.906753 0.595063981 0.00012404 0.001886884 SLC35G2 ENSG00000168917 56.44011982 -1.103007996 0.000124362 0.001889944 TMEM186 ENSG00000184857 525.7038985 -0.653313965 0.000124477 0.001890768 PROCR ENSG00000101000 131.0683061 -0.858939072 0.000124575 0.001891323 LMO2 ENSG00000135363 6357.412034 0.765451863 0.000125704 0.001907538 MTERF2 ENSG00000120832 1269.821515 -0.675059709 0.000126186 0.001913921 HERPUD1 ENSG00000051108 9523.461355 0.829476024 0.000126375 0.001915811 KCNG2 ENSG00000178342 14.31596221 1.80521093 0.000126495 0.001915811 SLC31A1 ENSG00000136868 3312.741303 0.545078257 0.00012811 0.001935571 CES1 ENSG00000198848 3296.864245 1.289916753 0.000128209 0.001936129 KDM4D ENSG00000186280 29.46691137 -1.259481187 0.000128629 0.001940583 TYMS ENSG00000176890 700.8187817 0.932251732 0.000128781 0.001941941 FUCA2 ENSG00000001036 3561.853504 0.648402006 0.000129116 0.001944626 ZNF285 ENSG00000267508 151.1140661 -1.062836867 0.000129319 0.001946276 ING1 ENSG00000153487 2840.330518 0.759360151 0.000130218 0.001956031 NR1H2 ENSG00000131408 4932.282318 0.533307724 0.000130478 0.00195813 MAFK ENSG00000198517 2379.712348 0.877158795 0.000133164 0.001991639 PCID2 ENSG00000126226 2890.05583 -0.565192373 0.000134597 0.002007297 VDAC2 ENSG00000165637 5154.146895 0.47272049 0.000134971 0.002011908 ITGA2B ENSG00000005961 3994.796831 1.171723136 0.000136793 0.002036149 TBKBP1 ENSG00000198933 2112.359601 -0.592493148 0.000136913 0.002036959

RAB3GAP1 ENSG00000115839 4040.209126 0.373204186 0.000137027 0.002037675 BCAT1 ENSG00000060982 899.4388639 1.062408204 0.000137917 0.002049034 RPAP2 ENSG00000122484 2451.062205 -0.71813475 0.000139953 0.002076231 MSR1 ENSG00000038945 1051.910522 1.122524708 0.000141379 0.00209539 RNF10 ENSG00000022840 11269.58733 0.502098636 0.000141851 0.002101388 GNAS ENSG00000087460 28836.73118 0.418249027 0.000144196 0.002132081 ZNF260 ENSG00000254004 895.4960396 -0.902397108 0.000145406 0.002148941 ANLN ENSG00000011426 152.0890307 0.977572193 0.000147061 0.002170323 ZNF831 ENSG00000124203 6204.796211 -0.800724898 0.000147158 0.002170714 TMEM64 ENSG00000180694 956.9666847 -0.680340125 0.000147829 0.002177539 ECI2 ENSG00000198721 2735.508547 -0.378668808 0.000147993 0.002178418 RFLNB ENSG00000183688 9666.490062 0.48031506 0.000148435 0.002180188 UNC119B ENSG00000175970 2468.263642 -0.401949576 0.00014857 0.002180188 TRIM46 ENSG00000163462 680.8391601 -0.823382332 0.000148445 0.002180188 MS4A4A ENSG00000110079 594.1175211 0.915353042 0.000148321 0.002180188 CD86 ENSG00000114013 7116.430955 0.720613533 0.000148884 0.002182744 MAT2B ENSG00000038274 9590.448239 -0.505740584 0.000150131 0.002198955 SLC25A12 ENSG00000115840 1194.130565 -0.362274049 0.000150568 0.002204219 TFRC ENSG00000072274 6021.001374 0.636320529 0.000150814 0.002204822 TSPAN4 ENSG00000214063 1208.401035 0.701916645 0.000151024 0.002205815 MEF2A ENSG00000068305 6945.707447 0.866853328 0.000150999 0.002205815 PDAP1 ENSG00000106244 4992.160799 0.401056038 0.000151221 0.00220662 NFAM1 ENSG00000235568 10990.38646 0.923758178 0.000151165 0.00220662 NCKAP1 ENSG00000061676 368.0401459 -0.729040041 0.000151488 0.002208446 NRG1 ENSG00000157168 1861.48285 1.06971124 0.000151463 0.002208446 SF1 ENSG00000168066 32080.23062 0.465934128 0.000153139 0.00222627 SLC35A2 ENSG00000102100 478.5436363 0.54072644 0.000154484 0.002241258 CLEC11A ENSG00000105472 281.8288081 0.900451696 0.000154657 0.002241258 ABCC3 ENSG00000108846 2287.952021 0.855475845 0.000154869 0.002242536 NAGA ENSG00000198951 8522.124403 0.578687315 0.000155976 0.00225279 EPSTI1 ENSG00000133106 8231.55265 0.885589921 0.00015695 0.002262665 NFKB2 ENSG00000077150 10056.9425 0.689831655 0.000157692 0.002271266 ANPEP ENSG00000166825 23353.60347 1.038758557 0.000157799 0.002271753 CERS4 ENSG00000090661 1326.140603 -0.573493826 0.000158261 0.002276018 WDR5B ENSG00000196981 746.6577034 -0.683046851 0.00015893 0.002282755 KCNE1 ENSG00000180509 1085.553182 1.290413065 0.000159024 0.002283052 CTNNB1 ENSG00000168036 12858.5796 0.375175204 0.000159436 0.00228653 P3H4 ENSG00000141696 234.334769 -0.902894023 0.000159486 0.00228653 PTPN22 ENSG00000134242 6526.22176 -0.472284319 0.000159596 0.002286747 ZNF527 ENSG00000189164 357.2756199 -0.854782521 0.000159795 0.002286747 CCDC71L ENSG00000253276 1320.433542 0.700146526 0.000159754 0.002286747 PSMD12 ENSG00000197170 3235.289558 0.53066991 0.000159883 0.002286962 SLU7 ENSG00000164609 6369.116426 0.356645597 0.000162623 0.002317633 FANCG ENSG00000221829 924.2122057 -0.423448122 0.000163696 0.002331866 ADRB2 ENSG00000169252 1302.741426 -0.962840796 0.000164358 0.00233915 HENMT1 ENSG00000162639 1724.476768 -0.566804074 0.000166105 0.002362945

PARL ENSG00000175193 3271.446773 0.451295758 0.000167485 0.002380397 HSD17B7 ENSG00000132196 1247.483743 -0.487798636 0.000168122 0.002387271 LPCAT1 ENSG00000153395 14606.56305 -0.662501928 0.000168075 0.002387271 BCL7B ENSG00000106635 3572.332169 0.46456974 0.000169284 0.002402682 KLC2 ENSG00000174996 1879.839908 -0.518656642 0.000170131 0.002412502 EIF3F ENSG00000175390 13580.29409 0.439858132 0.000170798 0.002420852 SUPV3L1 ENSG00000156502 2472.82843 0.497516407 0.000171299 0.002426855 PAIP2B ENSG00000124374 710.6287418 -0.621179477 0.000171789 0.002431582 ZNF281 ENSG00000162702 2915.169886 0.736520797 0.000173191 0.002447173 ILF2 ENSG00000143621 10119.80975 0.425508953 0.000173205 0.002447173 KBTBD11 ENSG00000176595 2157.378776 1.141539542 0.000173482 0.002447476 MRAS ENSG00000158186 320.2932889 0.896365303 0.00017354 0.002447476 COL6A2 ENSG00000142173 4529.399958 -0.995832069 0.000174777 0.0024638 TET3 ENSG00000187605 10325.47941 0.691319624 0.0001758 0.002473618 ZNF30 ENSG00000168661 262.7766918 -1.166332523 0.000176466 0.002479751 TNF ENSG00000232810 1161.172704 0.793582179 0.000179114 0.002511305 RASGEF1B ENSG00000138670 2411.202346 0.776405998 0.000182344 0.00255363 GLT1D1 ENSG00000151948 6109.451952 0.834543505 0.000182379 0.00255363 ZNF697 ENSG00000143067 528.1919909 0.827749073 0.000182697 0.002556931 CDC34 ENSG00000099804 2487.453362 1.00729448 0.000183694 0.002568578 PCYT2 ENSG00000185813 1548.211638 -0.481462319 0.00018414 0.002571359 CD79B ENSG00000007312 3170.311728 -0.656883644 0.000186178 0.00259632 HTR7 ENSG00000148680 113.0446436 0.764144281 0.000186323 0.002597179 RBM4B ENSG00000173914 1284.29021 -0.423024874 0.000186772 0.00259996 MTMR3 ENSG00000100330 9494.367457 0.569251915 0.000187129 0.002602599 MEAF6 ENSG00000163875 2936.213879 -0.377543127 0.000190393 0.002640919 LRRC32 ENSG00000137507 55.11764291 1.099754574 0.000190777 0.002645064 WDR35 ENSG00000118965 885.5594337 -0.696309989 0.000190871 0.002645197 KHSRP ENSG00000088247 7429.484362 0.280449139 0.000192827 0.002666367 PDS5B ENSG00000083642 3122.910233 0.469081918 0.000193113 0.002667952 ATP6AP2 ENSG00000182220 7869.599291 0.840245027 0.000193286 0.00266916 C5AR1 ENSG00000197405 17596.74629 1.073582125 0.000193621 0.002672605 DAPK1 ENSG00000196730 8397.492141 0.639994494 0.000194429 0.002681376 CDC14B ENSG00000081377 968.7560783 -0.67360502 0.00019454 0.00268173 ENDOD1 ENSG00000149218 1907.789191 -0.436251292 0.000194837 0.002684634 CSNK1G2 ENSG00000133275 11914.1079 0.406700648 0.000196286 0.002701755 LAMTOR5 ENSG00000134248 3243.27751 0.562138091 0.000196862 0.002706551 ABHD8 ENSG00000127220 747.3675948 0.618030289 0.00019725 0.002710687 RAB3A ENSG00000105649 159.9371567 0.893040227 0.000199445 0.00273652 DNAJB12 ENSG00000148719 4128.230767 0.539326318 0.00020018 0.002744902 EXTL2 ENSG00000162694 365.2364526 -0.772000046 0.000200496 0.002748025 MPP3 ENSG00000161647 63.00783429 0.932040681 0.000201365 0.002758722 DUSP7 ENSG00000164086 2931.703145 0.579860127 0.000201766 0.002762995 AC013461.1 ENSG00000091436 2324.167818 0.714324601 0.000202099 0.002766347 RP1-241P17.4 ENSG00000228532 136.5880686 0.588159048 0.000202666 0.002772011 TMTC2 ENSG00000179104 1751.663702 0.571035701 0.00020349 0.002779387

MON1A ENSG00000164077 540.8196274 -0.76583314 0.000206212 0.002802936 ZC3H15 ENSG00000065548 6861.302219 0.505016931 0.000206899 0.002811047 WASF2 ENSG00000158195 26698.70033 0.417315967 0.000210633 0.002858044 OPA1 ENSG00000198836 5466.65439 0.38981041 0.000211021 0.00286206 DOCK1 ENSG00000150760 135.6332618 0.919151128 0.000211435 0.002866426 ZNF70 ENSG00000187792 531.8527334 -0.585958533 0.000212437 0.002875007 ZFAND5 ENSG00000107372 19298.15034 0.519069596 0.00021437 0.002898646 TXNDC11 ENSG00000153066 4529.161058 0.509690993 0.000214304 0.002898646 ZNF302 ENSG00000089335 3148.960656 -0.514861207 0.000214602 0.002900527 MKKS ENSG00000125863 1762.600995 -0.612532373 0.000214915 0.00290349 RP11-455G16.1 ENSG00000178636 25.04910248 -1.258294858 0.000215324 0.002906496 ARL5B ENSG00000165997 4183.067188 0.870570273 0.000215323 0.002906496 TGFBI ENSG00000120708 27063.07323 0.578049358 0.000215514 0.002906541 PIK3CB ENSG00000051382 2683.625445 0.544694129 0.000215463 0.002906541 USP6 ENSG00000129204 76.91722444 -0.96078983 0.00021584 0.002909684 ABHD1 ENSG00000143994 78.58684251 -0.655157229 0.000216587 0.00291849 PYGL ENSG00000100504 13807.66827 0.752386162 0.000218585 0.002940333 EMD ENSG00000102119 2203.442578 0.417030225 0.000218832 0.002941109 PPM1A ENSG00000100614 8113.601085 0.60546989 0.000219156 0.002944193 HEXIM1 ENSG00000186834 5980.460577 -0.307893478 0.000220233 0.002953564 FMNL1 ENSG00000184922 55339.5965 0.488193845 0.000220596 0.002956718 CDC7 ENSG00000097046 1379.418878 -0.532347037 0.000220658 0.002956718 NANS ENSG00000095380 2398.393784 0.601877223 0.000221733 0.002968568 AIM1L ENSG00000176092 182.8661633 -0.747671842 0.000223391 0.002989484 ZNF516 ENSG00000101493 2650.411803 0.757436608 0.00022432 0.002998768 BLOC1S2 ENSG00000196072 3165.544872 0.603296849 0.000225624 0.00301161 INPP5A ENSG00000068383 1703.506852 0.493891804 0.000227099 0.003027949 HPCAL4 ENSG00000116983 728.5358486 -0.995675945 0.000227237 0.003027949 DNM1 ENSG00000106976 218.2183246 1.023312471 0.000228074 0.003035535 MED13L ENSG00000123066 9881.152428 0.787891398 0.000228572 0.003040529 NDUFS6 ENSG00000145494 3238.502029 0.542347246 0.000228698 0.003040911 C1orf228 ENSG00000198520 2135.986989 0.6472309 0.000229791 0.003054146 SMS ENSG00000102172 3766.915812 0.540101281 0.000230418 0.003061165 ALB ENSG00000163631 35.00805738 1.70232985 0.000230815 0.003064093 IKBKAP ENSG00000070061 6238.679709 -0.39307466 0.000232903 0.003087596 POP1 ENSG00000104356 313.583061 -0.824543271 0.00023352 0.003093152 HEY2 ENSG00000135547 17.20927557 -1.751304151 0.000235088 0.003108631 PSMB7 ENSG00000136930 8245.553586 0.353858727 0.000239291 0.00315751 NBPF3 ENSG00000142794 794.988177 -0.95964563 0.000239554 0.003158307 NFKB1 ENSG00000109320 8511.171155 0.376926312 0.00023951 0.003158307 THBS1 ENSG00000137801 6659.480941 1.343445007 0.000240088 0.003164007 CPVL ENSG00000106066 25598.88006 0.769139983 0.000240227 0.0031645 TOMM20 ENSG00000173726 11150.26116 0.351205516 0.00024073 0.003169782 GPR183 ENSG00000169508 5609.225668 1.075673209 0.000241009 0.003172113 C1orf43 ENSG00000143612 6289.941413 0.477000548 0.000241443 0.003175144 DMXL2 ENSG00000104093 14688.58356 0.680831023 0.000242109 0.003182559

MARCO ENSG00000019169 2003.877254 1.323419288 0.000242795 0.003190229 FAM151B ENSG00000152380 451.9137326 0.988678906 0.000242964 0.003191099 MARCH1 ENSG00000145416 7002.076783 0.770718309 0.000243244 0.003192922 SEMA4F ENSG00000135622 788.8087247 -0.732472759 0.000243307 0.003192922 BNIP3 ENSG00000176171 1493.452348 -0.430518937 0.000244258 0.003201348 BCL6 ENSG00000113916 13571.63822 0.899233275 0.000246322 0.00322433 ENY2 ENSG00000120533 4871.722156 0.41526919 0.000247865 0.003241808 MARCH1 ENSG00000186205 2688.831596 0.769108937 0.000250084 0.003261244 FAM134C ENSG00000141699 3745.389889 -0.931017017 0.00025167 0.003280552 TNS1 ENSG00000079308 628.4254362 1.041776655 0.000253033 0.003294191 ZNF267 ENSG00000185947 3282.716922 1.017421388 0.000252902 0.003294191 PABPC3 ENSG00000151846 97.42920345 0.854406375 0.000252961 0.003294191 PGK1 ENSG00000102144 31675.61018 0.393474375 0.000254147 0.003307309 MARCH9 ENSG00000139266 2489.174922 -0.639676195 0.000254398 0.003309187 GTF2B ENSG00000137947 3096.920397 0.456944657 0.000256236 0.003331715 EPHA2 ENSG00000142627 124.918017 1.147849107 0.000256386 0.003332268 CA2 ENSG00000104267 856.0425524 1.005817931 0.000256566 0.003333222 DPCD ENSG00000166171 327.1012692 1.009806906 0.000257283 0.003338359 CDCA5 ENSG00000146670 220.8663154 1.121584845 0.000257602 0.0033411 RGL1 ENSG00000143344 527.6807287 0.797231639 0.00025825 0.003348117 ITGAM ENSG00000169896 36017.43586 0.610074919 0.000261657 0.003385248 NINJ2 ENSG00000171840 814.9539465 0.804866779 0.000262036 0.003385932 DNTTIP2 ENSG00000067334 5609.143677 0.635658721 0.000262186 0.003386459 CNBP ENSG00000169714 28511.60723 0.456265925 0.000263153 0.003397545 KIAA0586 ENSG00000100578 1673.694148 -0.569382364 0.000264174 0.003407893 CLIC5 ENSG00000112782 331.8559683 -0.75463857 0.000265236 0.003420185 ATP2B4 ENSG00000058668 15103.28279 -0.778994826 0.000265826 0.00342637 RAB39B ENSG00000155961 584.3147464 -0.680967138 0.000265984 0.003426989 RLF ENSG00000117000 5870.408137 0.512056054 0.000268846 0.003459577 FAM32A ENSG00000105058 6990.272211 0.45200865 0.000272684 0.003501729 TMEM117 ENSG00000139173 163.3385146 -0.762170262 0.000273372 0.003509124 CLPB ENSG00000162129 1363.581216 0.573278518 0.000274182 0.003515171 BNIP1 ENSG00000113734 850.1064759 0.487407942 0.000274104 0.003515171 TMEM169 ENSG00000163449 118.8970091 -0.848393227 0.000274123 0.003515171 GRIK1 ENSG00000171189 59.1599653 0.900278007 0.000274779 0.003519932 AKTIP ENSG00000166971 2426.697891 -0.588444871 0.000275181 0.003522113 GNA13 ENSG00000120063 19019.33527 0.448914808 0.000275538 0.003522113 CCDC114 ENSG00000105479 126.18981 -0.851510988 0.000275603 0.003522113 CEBPA ENSG00000245848 4289.069135 0.779734897 0.00027893 0.003557016 CHAF1A ENSG00000167670 1674.283122 0.373321097 0.000281901 0.003593034 PLXNA3 ENSG00000130827 4096.994855 -0.768260624 0.000282165 0.003593853 UBE2I ENSG00000103275 7060.674191 0.367314406 0.000282572 0.003597573 TTC38 ENSG00000075234 4050.161547 -0.873529476 0.000283069 0.003599704 NXT1 ENSG00000132661 1211.73552 0.661159298 0.000283058 0.003599704 SH3TC1 ENSG00000125089 5696.474371 0.677145014 0.000286181 0.003636085 C15orf41 ENSG00000186073 186.0486477 -0.864833252 0.000286527 0.003639004

FOXD2 ENSG00000186564 100.2769671 -0.732237808 0.000288044 0.003652309 TMEM14A ENSG00000096092 294.5570619 -0.870945842 0.000289529 0.003667342 PHF11 ENSG00000136147 5824.305925 -0.455275568 0.000289701 0.003667342 GDF15 ENSG00000130513 21.66198445 1.197930509 0.000289688 0.003667342 ABCG1 ENSG00000160179 2239.015266 1.010263615 0.000291988 0.0036888 FUS ENSG00000089280 22905.07254 0.294997192 0.000292901 0.003698845 ATG4A ENSG00000101844 1156.019715 -0.333036558 0.000293731 0.003707814 HK1 ENSG00000156515 15295.36579 0.728771237 0.000294286 0.003710311 TEX10 ENSG00000136891 2743.332911 -0.322949461 0.000294637 0.003713231 GEMIN5 ENSG00000082516 1006.669932 -0.490604615 0.000296309 0.003731293 BBS9 ENSG00000122507 843.2570012 -0.324267521 0.000297369 0.003743126 RSL1D1 ENSG00000171490 13096.98648 0.436254651 0.000300409 0.003776813 STK3 ENSG00000104375 805.7259184 0.448957796 0.000301633 0.003788062 RRP1B ENSG00000160208 4343.967436 -0.348541735 0.000302813 0.003800904 COPS9 ENSG00000172428 1355.165304 0.555065901 0.000302968 0.003801312 PGRMC1 ENSG00000101856 3306.295664 0.745368169 0.000304207 0.003814729 CARD8 ENSG00000105483 15465.04883 -0.544978006 0.000304458 0.003815399 PROX2 ENSG00000119608 171.565509 -0.802880718 0.000305451 0.003824767 LMBRD1 ENSG00000168216 5185.364369 0.39341889 0.000305829 0.003826426 SH3BP2 ENSG00000087266 26612.23056 0.527066366 0.000306627 0.003834869 DPYS ENSG00000147647 12.07335477 1.73315609 0.000307763 0.003839823 IRAK2 ENSG00000134070 741.1372795 -0.576130493 0.00031057 0.00386564 KIAA0513 ENSG00000135709 2100.505056 0.566810498 0.000310576 0.00386564 TRAK1 ENSG00000182606 7078.959468 0.331719932 0.000310418 0.00386564 RPA2 ENSG00000117748 4027.940086 -0.372919751 0.000315581 0.003920094 RAB32 ENSG00000118508 3154.263998 0.67129295 0.000315942 0.003921453 MT-ND2 ENSG00000198763 278361.0046 0.561952796 0.000316075 0.003921539 OLA1 ENSG00000138430 3781.365637 0.382226831 0.000316387 0.003923355 CD74 ENSG00000019582 225494.8637 0.553372959 0.000316473 0.003923355 MUTYH ENSG00000132781 1269.151754 -0.339189213 0.000316676 0.003924313 HPX ENSG00000110169 71.19029917 1.540796637 0.00031686 0.003925031 PRSS57 ENSG00000185198 106.6138618 -1.165880655 0.000318947 0.003946182 HMGN2 ENSG00000198830 15928.03778 0.460962034 0.000319999 0.003956047 IFI6 ENSG00000126709 3625.062686 1.009815932 0.000323649 0.00399483 LY86 ENSG00000112799 2518.055047 0.588540952 0.000324915 0.004007289 R3HCC1L ENSG00000166024 3678.962265 0.421178925 0.000325762 0.004014559 KIF13A ENSG00000137177 4062.620578 0.694171777 0.000327033 0.004027028 ALDOC ENSG00000109107 1353.661383 -0.490438757 0.000327889 0.004035972 PPP1R9B ENSG00000108819 21399.96582 0.537838664 0.000328149 0.00403618 BTF3 ENSG00000145741 34653.65656 0.429693029 0.000329542 0.004048319 ZNF75D ENSG00000186376 2401.754728 -0.471602289 0.000330008 0.004049257 CCM2 ENSG00000136280 8410.674098 -0.421329365 0.000329927 0.004049257 SZRD1 ENSG00000055070 12180.8167 0.406779068 0.000331071 0.0040591 HEBP2 ENSG00000051620 6698.259984 0.382569401 0.000332605 0.0040747 ZNF485 ENSG00000198298 240.0668737 -0.829504826 0.000332864 0.004075171 KNL1 ENSG00000137812 275.0741952 0.569024387 0.000333746 0.004078876

OR5K2 ENSG00000231861 43.09879145 -1.130534045 0.000333937 0.004078876 MPHOSPH8 ENSG00000196199 8674.526496 -0.44494706 0.000333902 0.004078876 CHST15 ENSG00000182022 13209.63931 0.741092407 0.000335246 0.00409097 NINL ENSG00000101004 626.1712342 -1.141181731 0.000335771 0.00409577 C12orf49 ENSG00000111412 2863.160445 -0.389159509 0.000337532 0.004114029 ACP5 ENSG00000102575 2359.954135 0.762190459 0.000338258 0.004119659 AZIN2 ENSG00000142920 252.327749 -0.905861265 0.000341381 0.004149581 CCNA2 ENSG00000145386 475.4181233 0.70223387 0.000341842 0.004153572 C21orf62-AS1 ENSG00000205930 102.0813796 -0.902677971 0.000342516 0.004160137 PRDM8 ENSG00000152784 849.9021131 -0.680345556 0.000342919 0.004163402 APMAP ENSG00000101474 17030.12755 -0.518313466 0.000343224 0.004165482 TOP2A ENSG00000131747 760.35741 0.790159852 0.000346117 0.004194058 RAB39A ENSG00000179331 237.5821726 0.857174809 0.000346073 0.004194058 GNL2 ENSG00000134697 4258.706871 0.29171554 0.000346678 0.004199222 NUDT4 ENSG00000173598 3144.691638 0.756017158 0.000347203 0.004202316 WNT10A ENSG00000135925 141.341121 -0.961411323 0.000347199 0.004202316 ARPC2 ENSG00000163466 49715.71489 0.375048843 0.000347551 0.004204898 DDX28 ENSG00000182810 1568.81001 0.436968493 0.000349548 0.004219223 SLITRK4 ENSG00000179542 515.8659657 0.719041384 0.000349331 0.004219223 INTS6 ENSG00000102786 5154.939444 -0.417644351 0.000349023 0.004219223 PRDX3 ENSG00000165672 6016.918762 0.492807819 0.000349505 0.004219223 SLC4A4 ENSG00000080493 283.4020073 -1.144806905 0.000352324 0.004241229 RBM28 ENSG00000106344 3565.963823 -0.282783094 0.000357954 0.004299035 CAPN12 ENSG00000182472 396.9771829 -0.619934949 0.000357943 0.004299035 MYO18B ENSG00000133454 16.839478 -1.740395808 0.000357758 0.004299035 SMAP1 ENSG00000112305 3322.728386 0.435421091 0.000360033 0.004320673 HMG20B ENSG00000064961 3312.954693 0.566006929 0.000361494 0.004336532 THG1L ENSG00000113272 1058.210808 0.560461244 0.00036309 0.004352324 TLE3 ENSG00000140332 7600.802939 0.730455635 0.000363497 0.004355536 CDHR1 ENSG00000148600 373.0252269 -0.964868651 0.000363654 0.004355739 DUOX1 ENSG00000137857 158.3552634 -0.726101229 0.000368789 0.00440708 BCOR ENSG00000183337 3845.563235 -0.598636753 0.000370589 0.0044218 ADO ENSG00000181915 1625.343823 0.481700946 0.000372853 0.004443711 C1orf56 ENSG00000143443 237.3078694 -0.504088575 0.00037777 0.004491997 SLC23A1 ENSG00000170482 672.2555413 0.585344788 0.000377959 0.004492539 MORN4 ENSG00000171160 68.70274138 -1.042003524 0.000379258 0.00450626 CELSR2 ENSG00000143126 725.1028296 -0.650830479 0.000380013 0.0045135 IFITM3 ENSG00000142089 15297.87163 0.970920958 0.000380259 0.004514703 MAGEE1 ENSG00000198934 640.0292303 -0.748902836 0.00038065 0.004517624 TBC1D30 ENSG00000111490 288.2508009 0.78875457 0.000383521 0.004546502 ZC3H7A ENSG00000122299 8441.994594 0.471721025 0.000389928 0.004615427 YPEL2 ENSG00000175155 2282.760705 1.185038527 0.000391069 0.004625419 ATP6V1G1 ENSG00000136888 10489.85931 0.357601567 0.000393339 0.004646979 AP5B1 ENSG00000254470 7979.812544 0.787612849 0.000393972 0.004650928 GPD1L ENSG00000152642 1399.977155 -0.737134239 0.000395149 0.00466129 EIF3M ENSG00000149100 11394.66505 0.368880403 0.000395961 0.004663076

TIPARP ENSG00000163659 4056.284419 0.60388699 0.000395931 0.004663076 DDX17 ENSG00000100201 72555.07181 -0.274869036 0.000395491 0.004663076 APOBR ENSG00000184730 13551.29706 0.883664171 0.000396471 0.004666281 TPX2 ENSG00000088325 435.6415924 0.747566317 0.000396963 0.004670314 SIGLEC15 ENSG00000197046 302.3340855 0.732602707 0.000398487 0.004686467 ABCA1 ENSG00000165029 2458.518224 1.224051516 0.000400456 0.004706075 LCMT2 ENSG00000168806 315.7773886 -0.627408168 0.000403086 0.004731623 SYN1 ENSG00000008056 33.92499459 1.099504434 0.000402964 0.004731623 RAD9A ENSG00000172613 2134.136472 -0.416773758 0.000403366 0.004733132 CALN1 ENSG00000183166 5.921490336 -1.744311537 0.000405788 0.004754384 PSPN ENSG00000125650 173.8441916 -0.702124746 0.000405746 0.004754384 GSG2 ENSG00000177602 95.67388331 0.945413834 0.00040636 0.004759306 HIC1 ENSG00000177374 964.7485855 1.439717927 0.000406749 0.004762067 PDZK1 ENSG00000174827 111.5418794 -0.625327868 0.000408801 0.004784296 BNIPL ENSG00000163141 113.4336126 -0.885104311 0.000409433 0.004788089 UBALD2 ENSG00000185262 10878.6912 0.757458865 0.000411812 0.00481049 DNAJC28 ENSG00000177692 53.68966526 -1.182346666 0.000412648 0.004818451 SERPING1 ENSG00000149131 1875.002503 1.150992698 0.000413785 0.004827384 GNAI2 ENSG00000114353 63533.15187 0.534509071 0.000414918 0.004835903 SNX13 ENSG00000071189 3164.396995 0.549387366 0.00041525 0.004837961 RAB1A ENSG00000138069 6335.517488 0.630082662 0.000416297 0.004848341 CTNNA1 ENSG00000044115 9353.975139 0.598912657 0.000420467 0.004885951 DLGAP5 ENSG00000126787 169.4711203 0.965582044 0.000421193 0.004890738 KCNMB4 ENSG00000135643 219.6584541 0.889246522 0.000421467 0.004892101 ACAD8 ENSG00000151498 2963.375423 -0.260865043 0.000422377 0.004900834 TOX ENSG00000198846 1264.08344 -0.624572311 0.000424534 0.004922196 PDE4B ENSG00000184588 8089.363938 0.621514389 0.000425718 0.00493041 TRAPPC9 ENSG00000167632 2505.057611 0.314141705 0.000426729 0.004940286 CTIF ENSG00000134030 1192.71261 0.844866611 0.000426941 0.004940912 FAM171A1 ENSG00000148468 322.1117972 -0.950794249 0.000427998 0.004950291 COL13A1 ENSG00000197467 163.5801003 -1.60120713 0.000431917 0.004989227 LOXL3 ENSG00000115318 1570.531738 0.628759786 0.000432686 0.004996254 ZNF550 ENSG00000251369 1715.205651 -0.617418337 0.000435074 0.005020107 MASTL ENSG00000120539 1267.514608 0.649240381 0.000435666 0.005022651 PLAU ENSG00000122861 104.7872022 1.196883813 0.000435551 0.005022651 COPRS ENSG00000172301 501.9616623 0.545379695 0.000435778 0.005022651 COMT ENSG00000093010 3403.296957 0.550520121 0.000437175 0.005033166 PHLPP2 ENSG00000040199 1434.698252 -0.457869137 0.000437023 0.005033166 VPS4B ENSG00000119541 4658.768258 -0.598472762 0.000437768 0.005036935 SDF4 ENSG00000078808 8393.415533 0.470448475 0.000439862 0.005054766 AC110781.3 ENSG00000176349 28.47280809 -1.317539587 0.000440116 0.00505582 ALDH1B1 ENSG00000137124 322.5412686 -0.54816115 0.00044046 0.005057905 GIMAP6 ENSG00000133561 7965.786981 -0.684172678 0.000441277 0.005065412 SPARC ENSG00000113140 5048.311147 1.044229731 0.000443673 0.005088222 BTG3 ENSG00000154640 971.9043415 0.743225952 0.000444356 0.005091387 ATP8B1 ENSG00000081923 182.5352931 -0.722420435 0.000447167 0.005117938

SLC3A2 ENSG00000168003 6671.957161 0.423737672 0.000447409 0.005118835 CDIP1 ENSG00000089486 2329.103472 -0.439618648 0.000454072 0.005187442 MAPT ENSG00000186868 67.55312724 -0.695159448 0.000455696 0.005199435 UMPS ENSG00000114491 970.250705 -0.693842055 0.00045577 0.005199435 JADE2 ENSG00000043143 9110.877481 -0.813227127 0.000455898 0.005199435 CCND2 ENSG00000118971 6656.990186 -0.508951078 0.000457873 0.005211757 KDELR1 ENSG00000105438 5057.660817 0.625651828 0.000457834 0.005211757 TGFBR3 ENSG00000069702 4349.717705 -0.772933903 0.00045833 0.005215047 ZNF185 ENSG00000147394 4527.701434 0.617704668 0.000460239 0.005231043 FAM49A ENSG00000197872 9404.829911 0.718340061 0.000462331 0.00524808 GAS2L1 ENSG00000185340 1074.61662 0.658783777 0.000462152 0.00524808 SMKR1 ENSG00000240204 104.4235203 -1.027220704 0.000462967 0.005250552 AGAP1 ENSG00000157985 801.4076718 -1.00697239 0.000466363 0.005281378 ZSCAN21 ENSG00000166529 559.4225121 -0.57774751 0.000467111 0.005285134 CLEC7A ENSG00000172243 15926.77346 0.939270067 0.000466928 0.005285134 SPTAN1 ENSG00000197694 20860.66451 -0.430002519 0.000467204 0.005285134 ADCY3 ENSG00000138031 1940.652654 0.582387826 0.00047088 0.005317071 C5orf51 ENSG00000205765 1903.320621 -0.639953918 0.000475207 0.005358166 COX4I1 ENSG00000131143 15856.99549 0.468907287 0.000476989 0.005374367 ZFYVE28 ENSG00000159733 2519.940416 -0.623163341 0.000478008 0.005380011 EXO1 ENSG00000174371 97.37840621 0.734257715 0.000481465 0.005415003 FCGR1B ENSG00000198019 683.6439402 1.061549314 0.000482383 0.005417505 UST ENSG00000111962 615.9229405 -0.536537196 0.000482094 0.005417505 FRMD8 ENSG00000126391 3460.501833 -0.600789733 0.000483316 0.005424346 LRRC43 ENSG00000158113 85.28614291 -1.177805051 0.000484506 0.005433512 HGH1 ENSG00000235173 465.3340452 -0.713077471 0.000484885 0.005435782 PSMB1 ENSG00000008018 8447.424476 0.367361816 0.000485057 0.005435782 ERP29 ENSG00000089248 17309.31566 0.470961437 0.000485784 0.005441971 MXI1 ENSG00000119950 3523.88479 1.122893294 0.000488497 0.005464498 TRIP13 ENSG00000071539 120.5278187 0.840641963 0.000491536 0.005494548 MRPL16 ENSG00000166902 2892.358767 0.330695658 0.000493235 0.005511564 DNAAF2 ENSG00000165506 552.1104605 -0.553531339 0.000494781 0.005523911 RCAN2 ENSG00000172348 135.5261813 -1.175303884 0.000497295 0.005548977 ETV6 ENSG00000139083 9764.774202 0.526002657 0.000497996 0.005554804 BAZ1B ENSG00000009954 6876.573555 -0.369085957 0.000499119 0.005563347 ZDHHC3 ENSG00000163812 4044.408247 0.526440502 0.000501449 0.005585323 PPP1R13B ENSG00000088808 1227.371654 -0.585960941 0.000502222 0.005589936 CLTA ENSG00000122705 4525.936098 0.524581942 0.000502731 0.005591608 PRF1 ENSG00000180644 9615.446611 -0.741578448 0.000505784 0.005621549 CCNI2 ENSG00000205089 118.8305499 -0.809591114 0.000509468 0.00564638 CEP76 ENSG00000101624 373.671178 -0.471571457 0.000509412 0.00564638 TOP1 ENSG00000198900 8080.612266 0.537016467 0.000513499 0.005687005 E2F1 ENSG00000101412 442.5338779 0.846518949 0.000517759 0.005726043 PPFIBP2 ENSG00000166387 1732.654826 0.635700944 0.000517638 0.005726043 DNASE1L1 ENSG00000013563 2566.111633 0.492544601 0.000517558 0.005726043 WNT10B ENSG00000169884 780.35866 -0.658536225 0.000518447 0.005731615

GSPT2 ENSG00000189369 729.1416144 -0.481583123 0.00051869 0.005732274 CTR9 ENSG00000198730 5198.421991 -0.488289611 0.000519197 0.005735836 DNAH10OS ENSG00000250091 231.0520193 -0.658820019 0.000520797 0.005749433 CD247 ENSG00000198821 16580.97768 -0.74208774 0.000520759 0.005749433 NAPRT ENSG00000147813 2312.157357 0.775110577 0.000523106 0.005770842 TNRC18 ENSG00000182095 10812.28238 0.424195717 0.000524052 0.005779214 ZW10 ENSG00000086827 1073.699297 -0.418051255 0.0005276 0.005808076 KCNH3 ENSG00000135519 912.9630252 0.649872447 0.00052813 0.005809799 ITIH1 ENSG00000055957 89.94273165 1.189345424 0.000529793 0.005819878 NFIX ENSG00000008441 351.1698298 1.082485684 0.000530857 0.005827862 NAPEPLD ENSG00000161048 944.6464439 -0.772190295 0.000530894 0.005827862 PPFIA3 ENSG00000177380 230.8245522 -0.742485952 0.000531445 0.005828899 PTDSS1 ENSG00000156471 7087.631157 0.424603541 0.00053155 0.005828899 MAP3K1 ENSG00000095015 22357.52861 0.520729346 0.000532172 0.005831612 AARS2 ENSG00000124608 1471.622214 -0.419411489 0.000532719 0.005835559 C5orf66 ENSG00000224186 98.04582857 0.804746971 0.000538733 0.00588901 ZC3H12A ENSG00000163874 5512.779828 0.897825237 0.000539608 0.005896509 RAD23A ENSG00000179262 5382.201611 0.577342183 0.000540967 0.005905142 FANCF ENSG00000183161 1001.024527 -0.53465515 0.000541688 0.00591095 CAMK1 ENSG00000134072 2552.998475 0.660889006 0.000542794 0.005914724 CEP170 ENSG00000143702 4074.320756 0.600054649 0.000545029 0.005930781 RBM42 ENSG00000126254 3272.826484 0.461119565 0.000546806 0.005944871 CAPRIN2 ENSG00000110888 3398.747479 -0.499610739 0.000551349 0.005982835 DOCK2 ENSG00000134516 36079.38873 0.35105175 0.000552583 0.005994138 TPI1 ENSG00000111669 21161.30988 0.512093178 0.000552954 0.005996078 AC129492.6 ENSG00000214999 79.26096695 -1.055147554 0.000555428 0.006016624 SPA17 ENSG00000064199 123.2706841 0.800421685 0.000556703 0.006024151 STPG1 ENSG00000001460 217.5149307 -0.631272445 0.000559119 0.006048195 NGDN ENSG00000129460 2665.498977 0.358504848 0.000560932 0.006065316 KCTD12 ENSG00000178695 19465.95519 0.590078236 0.000561091 0.006065316 CXorf56 ENSG00000018610 1492.986995 0.325970095 0.00056615 0.006111519 C19orf43 ENSG00000123144 11102.00883 0.501290601 0.000566499 0.006113165 EXOSC8 ENSG00000120699 2560.69552 -0.430454976 0.00056724 0.006119048 BCL9L ENSG00000186174 15006.38906 -0.54332546 0.000568988 0.006133655 FKBP10 ENSG00000141756 39.7679387 -1.243337595 0.000569842 0.006140734 PELI1 ENSG00000197329 14358.33873 0.807749866 0.000573417 0.006170716 STAU1 ENSG00000124214 7580.987833 0.315364903 0.00058137 0.006245516 DNAJC19 ENSG00000205981 1057.139846 -0.3921893 0.000582529 0.006253656 TRMT2B ENSG00000188917 3331.884563 -0.279897978 0.000585086 0.006276782 STRN4 ENSG00000090372 5879.492142 0.491161453 0.000585654 0.006278554 TRIQK ENSG00000205133 1278.021384 0.652078462 0.000586577 0.006286278 TICAM1 ENSG00000127666 2180.360211 0.630262602 0.000590372 0.006316089 DMTN ENSG00000158856 2661.463955 1.168183521 0.000591227 0.006320892 ANP32A ENSG00000140350 15894.73474 0.429383001 0.000594104 0.006347294 RHBDL1 ENSG00000103269 104.113796 0.821588882 0.000595705 0.006362218 FAM132A ENSG00000184163 62.64328234 0.842878131 0.000597039 0.006372099

PODN ENSG00000174348 249.3128135 -1.347745447 0.000597522 0.006375069 IFNAR1 ENSG00000142166 6589.859199 0.5888199 0.000601164 0.006408501 MGST1 ENSG00000008394 1135.423646 0.669922317 0.000602588 0.006420323 PRCP ENSG00000137509 7279.634502 0.592276508 0.000602949 0.006421972 TRUB2 ENSG00000167112 1303.740631 -0.378282773 0.000604044 0.00642924 CYC1 ENSG00000179091 3714.511459 0.509495093 0.000605027 0.0064375 RCOR1 ENSG00000089902 2712.493125 1.188148456 0.000608246 0.00646513 AKAP8 ENSG00000105127 6377.051987 0.290874007 0.000609195 0.006470806 ZNF415 ENSG00000170954 122.8422361 -0.772069582 0.000611135 0.006486989 HPRT1 ENSG00000165704 1849.213291 0.421710702 0.000619062 0.006553858 MRGBP ENSG00000101189 1831.554884 0.436377788 0.000619151 0.006553858 PLXDC2 ENSG00000120594 7859.735047 0.683532156 0.000624531 0.006606667 TPPP ENSG00000171368 290.2018704 -0.870263765 0.000625388 0.00661125 STYK1 ENSG00000060140 184.7373077 -0.983004454 0.000628295 0.006632374 EHF ENSG00000135373 16.8207309 -1.605860374 0.000628451 0.006632374 SESTD1 ENSG00000187231 2527.707443 0.787229698 0.000629331 0.006639406 ATF1 ENSG00000123268 2139.428759 -0.381853434 0.000632579 0.006666907 GAB1 ENSG00000109458 890.1058076 0.848612111 0.000633832 0.006677851 CUL5 ENSG00000166266 2577.465823 0.539138518 0.000635618 0.006694405 MSTO1 ENSG00000125459 1613.387919 -0.377568638 0.000636831 0.00670043 GEMIN6 ENSG00000152147 530.7182131 -0.60505469 0.000636835 0.00670043 ATP2B1 ENSG00000070961 10666.53777 0.586526574 0.00063803 0.006710728 B4GAT1 ENSG00000174684 265.4592322 -0.586962586 0.000639069 0.006719395 BOK ENSG00000176720 177.4297735 -1.112014457 0.000643613 0.006764887 ESRRA ENSG00000173153 3446.077343 0.642416499 0.000643987 0.006765522 UNC119 ENSG00000109103 3928.867779 0.656495621 0.000644108 0.006765522 XYLT2 ENSG00000015532 2488.113364 -0.340723116 0.000644345 0.006765736 IMPDH1 ENSG00000106348 10987.8956 0.548026501 0.000645268 0.006770861 WHAMM ENSG00000156232 6000.808397 0.458166103 0.000645212 0.006770861 HIKESHI ENSG00000149196 1287.405052 -0.479446153 0.000647584 0.006790588 EMC7 ENSG00000134153 2547.090249 0.421372827 0.000648591 0.006796568 BUB1 ENSG00000169679 335.6629878 0.808933574 0.000650988 0.006814815 HERC2 ENSG00000128731 6143.410675 -0.469859421 0.000653218 0.006833566 GLUL ENSG00000135821 38665.93536 0.755416433 0.00065399 0.006837049 RGS14 ENSG00000169220 7862.954072 -0.475712293 0.0006565 0.006856383 TRABD ENSG00000170638 11777.29855 0.457644289 0.000658267 0.006872535 LGALS3BP ENSG00000108679 3478.911157 0.85206383 0.000662611 0.006907826 RACGAP1 ENSG00000161800 845.0893606 -0.40723389 0.00066216 0.006907826 CENPW ENSG00000203760 183.924506 0.750947615 0.000662514 0.006907826 HYLS1 ENSG00000198331 299.4118364 -0.639784204 0.000663 0.006908058 ZNF330 ENSG00000109445 4061.871622 0.567869326 0.000664829 0.006922492 PTPRB ENSG00000127329 102.4306886 -0.820557282 0.000666201 0.006927036 SELENOO ENSG00000073169 4843.846354 0.483363061 0.000665954 0.006927036 IRF6 ENSG00000117595 73.65220852 -0.9895468 0.000667437 0.006933422 DDX49 ENSG00000105671 2700.229326 0.458513519 0.000668788 0.00694283 RARG ENSG00000172819 1163.312211 -0.433840377 0.000668744 0.00694283

UBAC1 ENSG00000130560 3390.149405 0.495957355 0.000669643 0.00694939 SIK1 ENSG00000142178 3169.820094 0.893485957 0.000677142 0.007010865 GLA ENSG00000102393 1931.824895 0.454060095 0.000679632 0.007031967 GCSAML ENSG00000169224 1097.310164 1.02774084 0.000680401 0.007035858 LY9 ENSG00000122224 5742.184445 -0.661832636 0.00068046 0.007035858 UBBP4 ENSG00000263563 105.9666816 1.227782362 0.000682139 0.007043871 SMAD6 ENSG00000137834 63.1033771 1.17119955 0.000684289 0.00706373 RAB37 ENSG00000172794 5877.449084 -0.818595217 0.000685528 0.007074181 LRRC4B ENSG00000131409 46.26910408 1.380373158 0.000689465 0.007112444 CD37 ENSG00000104894 24298.57848 0.395164816 0.000689922 0.007112452 SLC47A2 ENSG00000180638 6.863823068 -1.446858474 0.000694979 0.007155116 ZNF568 ENSG00000198453 635.9004316 -0.567705639 0.000694878 0.007155116 NNMT ENSG00000166741 20.01742143 1.639504964 0.000702259 0.007206246 ASTN2 ENSG00000148219 54.29450497 -0.922315585 0.000702101 0.007206246 CXCR4 ENSG00000121966 49378.82532 0.806597605 0.000703543 0.007215085 AASDH ENSG00000157426 1187.336525 -0.490369577 0.000703583 0.007215085 GNB4 ENSG00000114450 4827.78997 0.530735492 0.000705163 0.007228906 CRTAM ENSG00000109943 697.9704014 -0.733219376 0.000705844 0.007233505 TMEM67 ENSG00000164953 245.8016404 -0.650917062 0.000707876 0.007249561 OXA1L ENSG00000155463 12649.63678 0.42607894 0.00071182 0.007277991 GNB2 ENSG00000172354 15027.49141 0.572532979 0.000712966 0.00728518 USP42 ENSG00000106346 2100.626379 0.376439632 0.000713004 0.00728518 NACC2 ENSG00000148411 5562.002692 0.776548753 0.000720048 0.007347645 CEP78 ENSG00000148019 4353.188952 -0.773772489 0.000722587 0.007366321 ABCC5 ENSG00000114770 4568.763421 -0.485001201 0.000724851 0.007379743 UNC5A ENSG00000113763 85.41471201 0.903164335 0.000727059 0.007395426 TIMM23 ENSG00000265354 2117.318677 0.319792394 0.000729353 0.00741087 CMC1 ENSG00000187118 4357.641996 -0.458108812 0.000731028 0.007423226 SLC1A5 ENSG00000105281 4547.934075 0.798732027 0.000731599 0.007426595 PMPCB ENSG00000105819 6288.684277 0.281382773 0.000733646 0.007442529 EIF4G1 ENSG00000114867 15886.90178 0.363657875 0.000735246 0.007455171 IDI1 ENSG00000067064 3465.79431 0.451359079 0.000735371 0.007455171 ESPL1 ENSG00000135476 191.4991842 0.806970694 0.000739613 0.007490654 CHD1 ENSG00000153922 12711.15523 0.593836815 0.000742659 0.007514388 CD300E ENSG00000186407 30484.84776 0.728163213 0.000743849 0.007523984 C3AR1 ENSG00000171860 3181.825925 1.204505883 0.000750262 0.007583924 PGBD4 ENSG00000182405 524.4835227 -0.487654279 0.000751501 0.007590501 ASAH2 ENSG00000188611 97.38138313 -0.831984977 0.000752901 0.00760074 KLC4 ENSG00000137171 1394.961266 -0.313909798 0.000763772 0.007690552 OR2T8 ENSG00000177462 8.851629796 1.478369311 0.00076667 0.007717233 SMAP2 ENSG00000084070 47708.33962 0.489680598 0.000767311 0.007721186 CRYZ ENSG00000116791 1059.387806 -0.645604404 0.000768232 0.007727966 EMC6 ENSG00000127774 776.6409807 0.640392265 0.000769344 0.007734154 YDJC ENSG00000161179 854.0472814 0.507881335 0.000773518 0.007773604 TIMM21 ENSG00000075336 784.8915553 -0.398476257 0.000775224 0.007787784 NMD3 ENSG00000169251 3461.617182 0.387308408 0.000775429 0.007787784

SALL2 ENSG00000165821 200.3513384 -0.852680291 0.000775769 0.007788687 RLN2 ENSG00000107014 52.12771756 -1.282595477 0.000776766 0.007796185 PCDH12 ENSG00000113555 472.8349008 -0.460091658 0.000777046 0.007796489 FKBP8 ENSG00000105701 19170.02534 0.868984301 0.000777345 0.007796979 NCF2 ENSG00000116701 50937.78764 0.646677611 0.000782067 0.007836774 IER3 ENSG00000137331 1893.905984 0.626554892 0.000787935 0.00788796 MCOLN3 ENSG00000055732 113.4011771 -0.989089322 0.000790648 0.007907492 EIF3B ENSG00000106263 12147.72832 0.308447259 0.000792069 0.007916619 LIN7A ENSG00000111052 1944.694352 0.776495912 0.000793558 0.007928961 MYOF ENSG00000138119 4643.561039 0.858227266 0.000800202 0.007975888 PKN3 ENSG00000160447 290.6409481 -0.534289184 0.000800932 0.007979605 XAB2 ENSG00000076924 6517.38561 0.481458764 0.000801193 0.007979661 AP2A1 ENSG00000196961 10766.05766 0.525210193 0.000802823 0.007990786 CAPZB ENSG00000077549 22612.93967 0.45747443 0.000805029 0.008010183 PSMD6 ENSG00000163636 9929.018353 0.335434493 0.000809525 0.008049772 ZSWIM5 ENSG00000162415 322.9525972 -0.845931882 0.00081019 0.008053818 ANKRD13B ENSG00000198720 174.3594202 -0.706212406 0.000811575 0.008062436 DLAT ENSG00000150768 2031.471409 -0.350538694 0.000816268 0.008103895 PLAA ENSG00000137055 2688.479985 0.445236417 0.000817075 0.008106739 PPDPF ENSG00000125534 2471.675854 0.613036838 0.000816867 0.008106739 ZNF823 ENSG00000197933 220.1512524 -0.685863116 0.000817641 0.008109775 NUP93 ENSG00000102900 4423.080896 0.298598378 0.000819016 0.008115656 PANX2 ENSG00000073150 436.8167334 1.165896592 0.00081867 0.008115656 GRIP1 ENSG00000155974 118.7105906 -0.860577403 0.000819996 0.008121188 IFNLR1 ENSG00000185436 641.4453279 -0.691032193 0.000820873 0.008126308 ALPK2 ENSG00000198796 78.00237968 -1.394517933 0.000822931 0.008144085 SASH1 ENSG00000111961 1333.32047 0.872781319 0.000825604 0.008167946 OLFML2A ENSG00000185585 101.5977811 1.038507693 0.000826653 0.008175726 CEP70 ENSG00000114107 426.5583353 -0.74156724 0.000827281 0.008179347 LAMC1 ENSG00000135862 716.6976857 0.634887996 0.00082968 0.00820046 SNAI1 ENSG00000124216 166.4050241 1.229284586 0.000831229 0.008210556 TMEM171 ENSG00000157111 37.37650047 -1.49406098 0.000832703 0.008222513 KIF11 ENSG00000138160 571.154955 0.567421246 0.000833822 0.008228351 CREB3L4 ENSG00000143578 481.4228763 -0.406559425 0.000834248 0.008229944 RREB1 ENSG00000124782 4332.338211 0.532054076 0.000837795 0.008262324 RPS6KA5 ENSG00000100784 2362.934551 -0.496968945 0.000838392 0.008265203 PRKCSH ENSG00000130175 16952.20113 0.443834495 0.000839149 0.008265203 UQCRH ENSG00000173660 4918.595152 0.569391759 0.000840168 0.00827001 CDON ENSG00000064309 66.8845084 -1.080261752 0.000843339 0.008295981 PKMYT1 ENSG00000127564 129.6055984 0.958283329 0.000845533 0.008314946 ME1 ENSG00000065833 212.6983854 0.807341513 0.000846606 0.008321622 BID ENSG00000015475 4709.771011 0.573143576 0.000850597 0.008351564 TYROBP ENSG00000011600 11523.59488 0.621345392 0.000853703 0.008375085 PCTP ENSG00000141179 2014.95509 0.655354371 0.000855956 0.008385678 ARHGAP31 ENSG00000031081 3579.921906 0.452180736 0.000857446 0.008397633 PPOX ENSG00000143224 1772.532093 -0.421209248 0.00085974 0.008414293

FES ENSG00000182511 7865.903548 0.659388334 0.000860794 0.00841984 ICMT ENSG00000116237 1995.471926 -0.615416389 0.000861323 0.008422367 RCVRN ENSG00000109047 88.86127151 0.960004927 0.000864165 0.008444856 ELK1 ENSG00000126767 2370.780428 0.456036382 0.000866396 0.008461349 KIF4A ENSG00000090889 96.75138855 0.943270884 0.000871825 0.008501044 E2F8 ENSG00000129173 76.09795301 0.97299634 0.00087213 0.008501354 KIF13B ENSG00000197892 5038.796152 0.459760112 0.000875673 0.008530552 PRR16 ENSG00000184838 41.59843657 1.331356288 0.000876561 0.008533873 TGDS ENSG00000088451 872.7831612 -0.521602978 0.000878097 0.008546157 ZAP70 ENSG00000115085 22948.15212 -0.645424508 0.000882942 0.008583957 APEX2 ENSG00000169188 852.6406158 -0.673994291 0.00088779 0.008618948 PDIA3 ENSG00000167004 27193.77731 0.316094432 0.000888379 0.00862198 MAP7D3 ENSG00000129680 1211.567372 -0.341899089 0.000895697 0.008684889 RASGEF1A ENSG00000198915 1081.302997 -0.680708157 0.000903218 0.008736065 UNG ENSG00000076248 861.7459153 -0.543523798 0.000907141 0.008752271 SEC24B ENSG00000138802 5407.491441 0.407872577 0.000906531 0.008752271 NEO1 ENSG00000067141 719.3165735 -0.718610475 0.000906442 0.008752271 ZNF784 ENSG00000179922 522.0879796 0.522209258 0.000906618 0.008752271 APH1A ENSG00000117362 7201.429642 0.386063982 0.000907107 0.008752271 FBXL5 ENSG00000118564 27531.63628 0.520192386 0.000913454 0.008807716 UFD1L ENSG00000070010 6409.981875 0.433241087 0.000915284 0.008815371 C19orf12 ENSG00000131943 2304.044026 -0.462022038 0.000916613 0.0088218 MTM1 ENSG00000171100 1667.505617 0.430665483 0.000922102 0.008871888 S100A11 ENSG00000163191 21984.33926 0.645280377 0.000926028 0.008904835 GLIPR1 ENSG00000139278 10177.30778 0.641287962 0.000930272 0.008931396 MYO6 ENSG00000196586 646.123844 -0.93735405 0.000930294 0.008931396 RSRC2 ENSG00000111011 8651.496923 0.452836276 0.000931121 0.008933825 C17orf80 ENSG00000141219 1072.223109 -0.774247653 0.000932273 0.008942129 NCAM1 ENSG00000149294 1259.484486 -1.105705852 0.000938326 0.008991882 KCNT1 ENSG00000107147 78.44430437 -0.90332239 0.000938783 0.008993494 FCF1 ENSG00000119616 2134.983079 -0.596448172 0.000945892 0.009058818 PRIMPOL ENSG00000164306 1107.002483 -0.449101312 0.00095546 0.0091364 FAM72A ENSG00000196550 272.9385043 0.639925552 0.000956752 0.009140343 PDIK1L ENSG00000175087 745.6624327 0.69417676 0.000956418 0.009140343 KCNG1 ENSG00000026559 183.7180102 -1.16104763 0.000956598 0.009140343 KLHL4 ENSG00000102271 16.91241804 -1.622870837 0.00095865 0.009155668 UBE2S ENSG00000108106 1008.924251 0.723125336 0.000959621 0.00916213 CFL2 ENSG00000165410 993.3114482 0.736183296 0.000960288 0.009165688 ZNF41 ENSG00000147124 1302.5517 -0.580051733 0.000961069 0.00917033 ZBTB47 ENSG00000114853 942.7582612 0.742698522 0.000961903 0.009175482 YARS ENSG00000134684 5905.00563 0.23924878 0.000972849 0.009262882 SCOC ENSG00000153130 1367.794664 -0.486679669 0.00097432 0.009274051 PPP1R15B ENSG00000158615 14227.3628 0.444228247 0.000978195 0.009291979 ACP6 ENSG00000162836 940.084474 -0.454320825 0.000978941 0.009295313 UVRAG ENSG00000198382 2950.897639 0.441910572 0.000980686 0.009309045 NFYB ENSG00000120837 1756.443089 -0.403204333 0.000982981 0.009327991

HSPA5 ENSG00000044574 37322.17226 0.639497774 0.000985735 0.009351277 ZNF599 ENSG00000153896 446.1958389 -0.663940574 0.000986775 0.009358293 HIST1H4H ENSG00000158406 252.7259238 0.592356895 0.000987747 0.00936466 GSTA4 ENSG00000170899 108.0808894 -0.859485092 0.000994904 0.009426777 PMS1 ENSG00000064933 2433.439478 -0.485986599 0.000998904 0.009458925 GM2A ENSG00000196743 4153.860588 1.167746113 0.000999986 0.009463419 FAM150B ENSG00000189292 23.43333995 -1.221184535 0.001006822 0.009516548 FAM124B ENSG00000124019 109.9772255 0.635179583 0.001008605 0.009530507 MCU ENSG00000156026 1876.284782 0.683877302 0.001010009 0.009537989 GPR157 ENSG00000180758 379.9638219 -0.516988221 0.001011027 0.009542086 ZNF790 ENSG00000197863 230.2698757 -0.588324852 0.001014093 0.009567857 CES4A ENSG00000172824 992.4431864 0.460928939 0.001014845 0.009572052 CLK2 ENSG00000176444 7803.538095 -0.226293291 0.001018687 0.009605378 AZIN1 ENSG00000155096 7259.926803 0.542723619 0.001027676 0.009681348 ARHGAP10 ENSG00000071205 1031.59958 -0.574731401 0.001028007 0.009681537 SIAH2 ENSG00000181788 3676.445795 1.027182145 0.001030743 0.009701443 UGDH ENSG00000109814 789.6965326 -0.67763345 0.00103271 0.009714111 HSF1 ENSG00000185122 3821.549824 0.446269511 0.001032713 0.009714111 TMEM55B ENSG00000165782 3497.487227 0.443687973 0.001035981 0.009741909 ZCWPW1 ENSG00000078487 2418.333352 0.424541407 0.001042085 0.009784542 USF1 ENSG00000158773 9760.839721 0.459015093 0.001045553 0.009808242 ALDH18A1 ENSG00000059573 2218.190715 -0.541550506 0.001047273 0.009821416 PDGFRB ENSG00000113721 999.2207005 -0.948718439 0.001051501 0.00985107 SRM ENSG00000116649 1543.427518 0.609956397 0.001053839 0.009862208 DLG3 ENSG00000082458 1023.536521 -0.894267621 0.001056744 0.009880495 ERP44 ENSG00000023318 8745.171208 0.372507087 0.00105757 0.009885248 NIPSNAP3A ENSG00000136783 1945.534656 0.489903039 0.001068824 0.00995662 CA11 ENSG00000063180 688.2371021 -0.669217938 0.001068845 0.00995662 BCL2A1 ENSG00000140379 7798.79903 0.947735774 0.001072017 0.009978373 ARF1 ENSG00000143761 25981.2929 0.694058401 0.001075131 0.009999419 PPP4C ENSG00000149923 6569.288133 0.477248756 0.001075562 0.009999419 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 12. Significantly differential expressed genes in the comparison of LC with CHB

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (LC/CHB) adjustedb

RHOB ENSG00000143878 8402.417152 1.410881587 9.82E-13 2.02E-08 PKD2L2 ENSG00000078795 739.7838173 -0.931570866 7.40E-11 7.61E-07 ARL5B ENSG00000165997 3702.641674 -0.897364213 4.84E-09 1.13E-05 FAM50B ENSG00000145945 222.3037202 1.163806918 6.62E-09 1.13E-05 MED11 ENSG00000161920 970.7050816 0.821871934 5.14E-09 1.13E-05 TMEM102 ENSG00000181284 657.1227936 0.914977915 1.17E-08 1.84E-05 MET ENSG00000105976 116.3083563 2.018841985 1.31E-08 1.85E-05 BORCS6 ENSG00000196544 1315.11751 1.084719297 1.44E-08 1.85E-05 SCAF4 ENSG00000156304 6962.325597 -0.595470473 3.14E-08 3.59E-05 BHLHA15 ENSG00000180535 47.15647224 1.672891289 1.29E-07 9.53E-05 SDE2 ENSG00000143751 3429.764212 -0.958479346 1.30E-07 9.53E-05 ASB2 ENSG00000100628 301.4005117 1.148081915 1.46E-07 9.66E-05 SDHAF1 ENSG00000205138 698.8562954 0.942261718 1.69E-07 9.92E-05 C11orf68 ENSG00000175573 1959.368026 0.824501354 1.64E-07 9.92E-05 BOD1 ENSG00000145919 1006.915156 0.611893311 1.84E-07 0.000105363 SERTAD2 ENSG00000179833 7000.652901 -0.846821587 2.65E-07 0.000136413 JCHAIN ENSG00000132465 22869.74415 1.484065962 3.25E-07 0.000156384 YOD1 ENSG00000180667 3952.493468 -0.820757193 4.06E-07 0.00017766 PHGDH ENSG00000092621 280.1116332 1.088104499 4.05E-07 0.00017766 BOLA1 ENSG00000178096 294.4007376 0.91270799 4.71E-07 0.000201649 FANCE ENSG00000112039 619.0714326 0.821756678 5.36E-07 0.000208976 PIGA ENSG00000165195 2797.428917 -0.858634308 5.25E-07 0.000208976 LMOD2 ENSG00000170807 32.59581261 -1.531643273 6.27E-07 0.000226255 RBM38 ENSG00000132819 8065.699701 -1.113338075 6.49E-07 0.000227876 ALDH1B1 ENSG00000137124 339.6752579 0.686054341 6.84E-07 0.000230491 MRPS18A ENSG00000096080 1127.320481 0.709044277 7.07E-07 0.00023451 AUH ENSG00000148090 4586.904736 -0.660042699 8.62E-07 0.000272589 ZNF14 ENSG00000105708 1589.2316 -1.068842157 1.50E-06 0.000409451 KANSL1 ENSG00000120071 8142.587615 -0.448662955 1.62E-06 0.000413354 PYCRL ENSG00000104524 217.7314538 0.839030955 1.65E-06 0.000413354 MGAT2 ENSG00000168282 2149.729856 0.939916576 1.96E-06 0.000453014 TARS2 ENSG00000143374 2015.343003 0.492114822 1.95E-06 0.000453014 ITM2C ENSG00000135916 2301.695633 1.051922075 2.02E-06 0.000460307 RPRD1A ENSG00000141425 2357.494397 -0.552974618 2.10E-06 0.000460307 CDK4 ENSG00000135446 1676.086194 0.802847507 2.08E-06 0.000460307 RPP25L ENSG00000164967 645.9360502 0.985467793 2.30E-06 0.000483054 NR4A3 ENSG00000119508 164.2488905 -1.512600791 3.11E-06 0.000597362 EXOSC4 ENSG00000178896 400.5403281 0.848391447 3.94E-06 0.000704349 KLHL29 ENSG00000119771 292.0491828 -0.969667123 4.89E-06 0.000838432 ANGPTL6 ENSG00000130812 197.368495 1.338738545 4.99E-06 0.000847409 KCTD11 ENSG00000213859 819.2098539 0.694685763 5.06E-06 0.000852847 POLG2 ENSG00000256525 3655.75487 -0.438400012 6.02E-06 0.000975124

TMEM120B ENSG00000188735 2708.937422 0.985098885 7.10E-06 0.001096972 PPTC7 ENSG00000196850 8919.686872 -0.574448869 7.23E-06 0.001110069 LCMT2 ENSG00000168806 323.8382175 0.930782045 7.45E-06 0.001117911 MASTL ENSG00000120539 1068.26548 -0.786365614 7.40E-06 0.001117911 CEP250 ENSG00000126001 5658.929254 0.736650316 7.83E-06 0.001150474 AVPR1A ENSG00000166148 43.50858599 1.239458049 8.03E-06 0.001171267 SLC23A1 ENSG00000170482 589.8866436 -0.679975405 1.08E-05 0.001513527 PTS ENSG00000150787 1615.298517 -0.78398954 1.11E-05 0.001545567 SEC61A2 ENSG00000065665 1520.000987 -0.5585036 1.28E-05 0.001708535 ARCN1 ENSG00000095139 5929.11435 0.782643944 1.28E-05 0.001708535 TIGD5 ENSG00000179886 641.0988387 0.782091955 1.29E-05 0.001708535 FAM188A ENSG00000148481 3609.812025 -0.667726863 1.31E-05 0.001723099 AHSA1 ENSG00000100591 4509.815307 0.50815769 1.32E-05 0.001723586 GPRC5D ENSG00000111291 84.70818035 1.387759338 1.41E-05 0.001807192 SLC30A1 ENSG00000170385 3469.128943 -0.646258059 1.56E-05 0.001942162 RGS14 ENSG00000169220 8811.488266 0.637601037 1.63E-05 0.002008534 HNRNPF ENSG00000169813 13391.15562 0.604190572 1.66E-05 0.002027323 GIMAP7 ENSG00000179144 7096.635464 1.089071741 1.77E-05 0.002123475 IRF2BP1 ENSG00000170604 1752.291082 0.754394146 1.83E-05 0.002176663 CCDC97 ENSG00000142039 3423.555299 0.65076684 1.85E-05 0.00217691 LIN7C ENSG00000148943 2474.003702 -0.530893093 1.86E-05 0.00217691 SFPQ ENSG00000116560 22148.98556 -0.497172902 1.91E-05 0.002209564 PP2D1 ENSG00000183977 291.4333862 -0.657878212 1.92E-05 0.002209564 NOA1 ENSG00000084092 2591.189325 0.43010976 1.91E-05 0.002209564 FAM91A1 ENSG00000176853 3640.866585 -0.814136288 1.95E-05 0.002222627 PDCD7 ENSG00000090470 2056.537644 0.502728672 1.99E-05 0.002255884 CTU1 ENSG00000142544 309.4489555 1.021138662 2.00E-05 0.002261242 NSDHL ENSG00000147383 832.0396214 0.535318498 2.24E-05 0.002390102 SNRPA1 ENSG00000131876 4891.905647 -0.778898758 2.21E-05 0.002390102 SOWAHD ENSG00000187808 303.9588534 0.952703654 2.23E-05 0.002390102 GEMIN2 ENSG00000092208 339.6487282 0.461062773 2.30E-05 0.002432409 C12orf71 ENSG00000214700 277.4730738 -0.814394892 2.37E-05 0.002481595 POU2F1 ENSG00000143190 3059.00574 -0.57843324 2.58E-05 0.002643626 JMJD1C ENSG00000171988 12469.76204 -0.76219905 2.62E-05 0.002650285 STIP1 ENSG00000168439 4890.704073 0.549742204 2.64E-05 0.002661943 GIPC1 ENSG00000123159 1902.29125 0.722511658 2.72E-05 0.002726389 RASGEF1B ENSG00000138670 2365.985972 -1.045142012 2.74E-05 0.002738211 LXN ENSG00000079257 314.2246708 0.760629161 2.79E-05 0.002769602 MRPL15 ENSG00000137547 1164.373703 0.581484811 2.92E-05 0.002846286 UNG ENSG00000076248 930.8878356 0.57484435 2.95E-05 0.002864231 LYL1 ENSG00000104903 2421.941795 0.809034558 3.23E-05 0.003087255 AVPR2 ENSG00000126895 582.9091441 -0.834337414 3.26E-05 0.003099312 RUVBL2 ENSG00000183207 2558.797694 0.548610143 3.39E-05 0.003165309 MAP3K1 ENSG00000095015 19711.29639 -0.620641672 3.53E-05 0.003252425 GPR15 ENSG00000154165 612.3211344 1.402513542 3.62E-05 0.0032891 SUGP1 ENSG00000105705 3222.182534 0.375132679 3.75E-05 0.003396496

DDX21 ENSG00000165732 11644.97013 -0.574193819 3.82E-05 0.003428732 RFX3 ENSG00000080298 2676.951093 -0.570106823 3.86E-05 0.003441594 GNA13 ENSG00000120063 16594.2534 -0.424813058 3.89E-05 0.003451038 ZNF256 ENSG00000152454 592.6819348 -0.682376571 3.93E-05 0.003467986 ZBTB10 ENSG00000205189 1237.488333 -0.871079413 3.96E-05 0.003470429 RINL ENSG00000187994 2751.649591 0.578719991 3.97E-05 0.003470429 SARS ENSG00000031698 7955.322285 0.382189883 4.05E-05 0.003526039 IKZF3 ENSG00000161405 11537.65646 1.036290599 4.37E-05 0.003653004 EEF2KMT ENSG00000118894 571.5987921 0.758478434 4.34E-05 0.003653004 FFAR2 ENSG00000126262 1096.863362 1.248744701 4.34E-05 0.003653004 BTG3 ENSG00000154640 1069.316959 -1.004660475 4.35E-05 0.003653004 RIOK3 ENSG00000101782 5695.158331 -0.516329504 4.41E-05 0.003670138 RWDD2B ENSG00000156253 583.9809879 0.594359008 4.50E-05 0.003701547 ENDOG ENSG00000167136 329.5354736 0.811839471 4.67E-05 0.003822595 BATF ENSG00000156127 1467.099424 0.825931352 4.75E-05 0.003847818 GIMAP6 ENSG00000133561 7836.412731 0.867961272 4.83E-05 0.003894597 FBLN5 ENSG00000140092 414.2351133 1.057791641 4.92E-05 0.00395392 SMURF2 ENSG00000108854 3027.500667 -0.388070099 4.98E-05 0.003983887 DNAAF2 ENSG00000165506 629.6989008 0.698649442 5.05E-05 0.004010337 TNFRSF8 ENSG00000120949 1096.183918 0.792028236 5.05E-05 0.004010337 POP7 ENSG00000172336 815.9886755 0.623648583 5.15E-05 0.004054755 TNFAIP6 ENSG00000123610 197.6920309 1.221334586 5.34E-05 0.004161563 HIST2H4B ENSG00000270276 257.1586644 0.77398685 5.50E-05 0.004267997 TNFRSF1A ENSG00000067182 5697.311545 0.849586585 5.53E-05 0.004275927 ENC1 ENSG00000171617 4077.259866 -1.048658082 5.66E-05 0.004345386 ABCB9 ENSG00000150967 310.9074435 1.053233376 5.74E-05 0.004369759 FBXW9 ENSG00000132004 246.1404303 0.613017569 6.23E-05 0.004607795 CHPF ENSG00000123989 432.5732974 0.929675774 6.41E-05 0.004724209 SLC43A1 ENSG00000149150 762.713907 0.581133345 6.46E-05 0.00474368 CX3CR1 ENSG00000168329 12622.43197 1.138818877 6.50E-05 0.004753699 CHIC2 ENSG00000109220 2484.029215 -0.630969538 6.80E-05 0.004825527 SEMA3G ENSG00000010319 91.47974912 1.053823398 6.87E-05 0.004825527 AGTPBP1 ENSG00000135049 12660.65615 -0.443034772 6.94E-05 0.004825527 TANGO2 ENSG00000183597 3941.332838 0.393757514 6.93E-05 0.004825527 SREK1 ENSG00000153914 8467.015269 -0.567523654 6.77E-05 0.004825527 UBR1 ENSG00000159459 4194.707333 -0.532266237 6.84E-05 0.004825527 FKBPL ENSG00000204315 155.5958486 0.871291771 6.76E-05 0.004825527 C18orf25 ENSG00000152242 4545.750715 -0.575061132 6.63E-05 0.004825527 APEH ENSG00000164062 5966.206727 0.450553667 7.08E-05 0.004886373 ILKAP ENSG00000132323 5189.155465 -0.589613451 7.32E-05 0.004952026 AQP3 ENSG00000165272 3272.136168 0.813280417 7.45E-05 0.005008238 TWNK ENSG00000107815 561.2084709 0.763762875 7.91E-05 0.005266169 TOLLIP ENSG00000078902 3407.766691 0.589919485 8.16E-05 0.005357307 ZNF786 ENSG00000197362 789.4115102 0.591571701 8.58E-05 0.005548926 AMMECR1 ENSG00000101935 2263.132319 -0.56252183 8.72E-05 0.005553893 TRMT112 ENSG00000173113 2285.771353 0.540540031 8.72E-05 0.005553893

HBP1 ENSG00000105856 5630.877774 -0.642161942 8.87E-05 0.005608731 ZBTB42 ENSG00000179627 268.5713761 0.723989368 8.97E-05 0.00565738 TNFRSF9 ENSG00000049249 240.9047231 0.983658386 9.13E-05 0.005680141 MZB1 ENSG00000170476 1903.692685 1.145131014 9.15E-05 0.005680141 FAM46A ENSG00000112773 4506.938501 -0.788813805 9.17E-05 0.005680141 CXCR6 ENSG00000172215 219.1521276 0.994242804 9.20E-05 0.00568169 PRMT6 ENSG00000198890 685.8923282 0.641269643 9.57E-05 0.005874155 ITPKC ENSG00000086544 794.8733641 0.752784818 9.66E-05 0.005874155 MON1A ENSG00000164077 689.7537884 0.805076726 9.60E-05 0.005874155 MRPL34 ENSG00000130312 1982.509243 0.469047261 9.64E-05 0.005874155 RP11-463J10.2 ENSG00000258928 584.1904355 -0.99224527 0.000100119 0.006054527 CEP89 ENSG00000121289 1211.463653 0.585866957 0.0001092 0.006488703 CEP170 ENSG00000143702 3523.764751 -0.616315225 0.000109507 0.006488703 CCDC50 ENSG00000152492 5246.333547 -0.803577609 0.000110141 0.006491247 GLDC ENSG00000178445 259.0561704 1.354049221 0.000112688 0.006619961 ASB14 ENSG00000239388 249.4776246 -0.696686479 0.000114926 0.006730234 ZNF835 ENSG00000127903 42.67867315 0.975828422 0.000115931 0.006733475 DHRS9 ENSG00000073737 360.9861742 0.898416353 0.000120418 0.006785794 DALRD3 ENSG00000178149 1419.184551 0.493405062 0.000119911 0.006785794 ZNF300 ENSG00000145908 563.6387741 -0.756719528 0.00012033 0.006785794 AURKA ENSG00000087586 225.5093808 0.987154713 0.000120151 0.006785794 CTB-50L17.10 ENSG00000167674 2812.483354 0.476371467 0.000122059 0.006801212 ZNF501 ENSG00000186446 98.83813009 0.970258003 0.000128248 0.007104835 NUDT4 ENSG00000173598 3048.407546 -0.890197383 0.000130882 0.007142841 CCDC102A ENSG00000135736 661.9906201 0.740910085 0.000131213 0.007142841 LCORL ENSG00000178177 1806.95443 -0.568928056 0.000130793 0.007142841 EEF1AKMT1 ENSG00000150456 169.5546625 0.719982797 0.000132516 0.007170168 MRPS12 ENSG00000128626 1176.16112 0.645641063 0.000134175 0.007176003 PRPF6 ENSG00000101161 9168.223681 0.331830352 0.000134369 0.007176003 ZNF575 ENSG00000176472 169.2741753 0.754198976 0.00013393 0.007176003 FZD7 ENSG00000155760 40.65875769 1.051482893 0.000134913 0.007186384 MRPL57 ENSG00000173141 1456.526842 0.5822333 0.000136581 0.007256441 MAGEH1 ENSG00000187601 798.9935694 0.581097499 0.000137658 0.007294811 FBXO2 ENSG00000116661 287.4178847 0.838852258 0.000146454 0.007642739 CORO1A ENSG00000102879 80005.87014 0.593922524 0.000150098 0.007734767 TIPARP ENSG00000163659 4407.610607 -0.774036235 0.000150784 0.007750668 SLC35A3 ENSG00000117620 2688.701896 -0.818146564 0.000154355 0.007855674 OXCT2 ENSG00000198754 48.36693932 1.157625284 0.000155346 0.007886612 CKS2 ENSG00000123975 360.8704084 0.80780553 0.000157991 0.007941839 CCDC73 ENSG00000186714 200.0637673 -0.753142328 0.000159138 0.007941839 B3GALT2 ENSG00000162630 51.0598875 1.214270573 0.000158991 0.007941839 ATP5D ENSG00000099624 1926.361384 0.862318824 0.000159088 0.007941839 TMEM99 ENSG00000167920 131.7679381 0.844000927 0.000159757 0.007945464 MRPL18 ENSG00000112110 1714.4647 0.453305918 0.00016263 0.007992094 PNPLA4 ENSG00000006757 438.5659863 0.567814228 0.000166786 0.008145584 MTG2 ENSG00000101181 2342.588911 0.564058578 0.000168255 0.008197866

KLF11 ENSG00000172059 7665.448188 -0.555417709 0.000171151 0.008280085 TWF1 ENSG00000151239 4481.509236 -0.595319509 0.000172085 0.00830169 ISCA1 ENSG00000135070 5113.931711 -0.729149695 0.00017289 0.008305566 BRD8 ENSG00000112983 3383.917769 0.482738527 0.000177708 0.008497321 ASCL2 ENSG00000183734 666.4742392 1.010844888 0.000179283 0.008532934 GTF2E2 ENSG00000197265 1648.95939 0.378873339 0.000181243 0.00856676 GCSAM ENSG00000174500 851.0866697 0.859727617 0.000186136 0.008734399 HSPA12B ENSG00000132622 207.5839952 -0.969701358 0.000186489 0.008734399 HTRA2 ENSG00000115317 1721.587203 0.40193141 0.000186112 0.008734399 CBLB ENSG00000114423 6892.037794 -0.565446464 0.000187641 0.008768373 C19orf25 ENSG00000119559 1176.412563 0.657227628 0.000188282 0.008778397 ZBTB21 ENSG00000173276 1685.820302 -0.755360472 0.000195813 0.009006981 HIRIP3 ENSG00000149929 1241.510409 0.535461449 0.00019579 0.009006981 ARID5A ENSG00000196843 4048.235877 -0.693826903 0.000196679 0.009026587 MASP2 ENSG00000009724 4365.15679 -0.646896164 0.000198888 0.009107664 PNP ENSG00000198805 3568.28104 0.572787546 0.000209281 0.009415819 CDC20 ENSG00000117399 276.9565496 1.204861193 0.000213106 0.009463649 U2AF1 ENSG00000160201 8109.432165 -0.661768517 0.00022263 0.009760106 TWISTNB ENSG00000105849 1294.150455 -0.777009064 0.000223964 0.009797689 RGCC ENSG00000102760 4220.12087 -0.83575603 0.000227246 0.009855703 SHMT2 ENSG00000182199 3106.641715 0.533955374 0.000230659 0.009942501 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 13. Significantly differential expressed genes in the comparison of LC with NC

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (LC/NC) adjustedb

TMEM160 ENSG00000130748 635.1321601 2.043048873 3.11E-30 6.21E-26 CEBPB ENSG00000172216 5494.814555 2.269799673 2.40E-20 1.59E-16 CCDC85B ENSG00000175602 1495.725252 1.250121991 1.23E-14 3.49E-11 C4orf48 ENSG00000243449 172.3389175 2.125663696 4.22E-14 1.05E-10 TMEM238 ENSG00000233493 54.43556273 2.024440015 4.45E-13 9.85E-10 LYL1 ENSG00000104903 2263.174394 1.101459645 7.71E-13 1.54E-09 CTU1 ENSG00000142544 300.3754316 1.189126542 2.07E-12 3.74E-09 NDUFAF8 ENSG00000224877 634.5922285 1.078221031 5.20E-12 8.64E-09 CHCHD10 ENSG00000250479 1092.585152 0.979693647 6.27E-12 9.61E-09 ZNF787 ENSG00000142409 2425.283623 0.880830597 3.66E-11 5.21E-08 H1FX ENSG00000184897 9941.019281 1.092248547 6.25E-11 8.30E-08 ZNF804A ENSG00000170396 317.5085726 1.109428766 1.06E-10 1.24E-07 C19orf60 ENSG00000006015 2805.944817 0.790145438 2.41E-10 2.53E-07 TPGS1 ENSG00000141933 745.9303822 0.84292921 2.37E-10 2.53E-07 EVA1B ENSG00000142694 379.1116042 1.328027876 3.38E-10 3.37E-07 IRF2BP1 ENSG00000170604 1781.953179 0.804663781 4.60E-10 4.16E-07 MET ENSG00000105976 105.8989747 1.691182016 8.47E-10 7.34E-07 YDJC ENSG00000161179 1053.2901 0.931646428 1.89E-09 1.57E-06 SPATA2L ENSG00000158792 662.6472121 0.919907487 3.18E-09 2.54E-06 FAM173A ENSG00000103254 576.9741721 0.928877024 4.05E-09 2.99E-06 TIGD5 ENSG00000179886 672.1702698 0.741931056 1.00E-08 6.87E-06 FBXL15 ENSG00000107872 937.160214 0.955814055 1.18E-08 7.58E-06 ZNF579 ENSG00000218891 451.1368876 0.824994853 1.16E-08 7.58E-06 PCSK1N ENSG00000102109 63.92324313 1.399694225 1.62E-08 9.80E-06 CFD ENSG00000197766 4496.263967 1.013754086 1.74E-08 1.02E-05 PUSL1 ENSG00000169972 660.4808733 0.737025089 3.75E-08 1.91E-05 SDF4 ENSG00000078808 9091.527161 0.600303995 4.02E-08 2.00E-05 HES4 ENSG00000188290 190.3646268 1.411173193 4.81E-08 2.34E-05 CDKN2A ENSG00000147889 195.8893374 0.659886189 5.63E-08 2.67E-05 SCAND1 ENSG00000171222 2841.803916 0.946408212 9.47E-08 4.11E-05 SOCS1 ENSG00000185338 236.1412956 1.32959767 9.21E-08 4.11E-05 MCOLN3 ENSG00000055732 115.2118183 -1.130007986 9.47E-08 4.11E-05 SH2B2 ENSG00000160999 927.5430181 0.87988441 1.37E-07 5.77E-05 CITED4 ENSG00000179862 511.8474264 1.263210305 1.39E-07 5.77E-05 ENDOG ENSG00000167136 337.3807904 0.823328558 1.49E-07 6.07E-05 PTMS ENSG00000159335 832.9033592 0.805242028 1.90E-07 7.57E-05 ASCL2 ENSG00000183734 645.141473 1.128133182 2.00E-07 7.75E-05 C1orf122 ENSG00000197982 930.682922 0.743350126 2.61E-07 9.64E-05 ZNHIT2 ENSG00000174276 315.3356167 0.745916262 3.08E-07 0.000107801 BHLHA15 ENSG00000180535 46.19621935 1.394022203 3.01E-07 0.000107801 CST3 ENSG00000101439 26720.77044 0.846336893 3.38E-07 0.00011623 CDC20 ENSG00000117399 256.365537 1.344962088 4.69E-07 0.000153228

STK11 ENSG00000118046 5936.882304 0.52400043 4.63E-07 0.000153228 CHPF ENSG00000123989 442.9355756 0.914902614 4.77E-07 0.000153286 PITPNM1 ENSG00000110697 11202.55318 0.560225924 5.18E-07 0.000163772 SCAF1 ENSG00000126461 3787.419226 0.639443429 6.17E-07 0.000192159 ZNF703 ENSG00000183779 1421.560603 0.905415863 6.82E-07 0.000205912 KRT10 ENSG00000186395 1046.242101 0.591111992 7.10E-07 0.000211104 TOR2A ENSG00000160404 2110.518094 0.592137087 9.66E-07 0.000279095 CCDC61 ENSG00000104983 1174.054293 0.494763037 9.63E-07 0.000279095 PWWP2B ENSG00000171813 1177.170612 0.659991226 1.10E-06 0.000312652 SRRM2 ENSG00000167978 57369.17217 0.935390466 1.32E-06 0.000371271 SLC38A10 ENSG00000157637 12510.10747 0.521905135 1.37E-06 0.000376667 ABHD8 ENSG00000127220 782.7917171 0.645102656 1.62E-06 0.000437598 MAP7D1 ENSG00000116871 12132.65578 0.507828529 1.69E-06 0.000441448 CSNK1G2 ENSG00000133275 12528.72211 0.453489522 1.73E-06 0.000441448 PTRH1 ENSG00000187024 245.275999 0.814623289 1.68E-06 0.000441448 UBE2S ENSG00000108106 1173.817395 0.9377907 1.72E-06 0.000441448 BCL11A ENSG00000119866 1714.307674 -0.438394523 1.81E-06 0.000455862 SDF2L1 ENSG00000128228 975.1008537 0.904598492 1.95E-06 0.000480095 STRADB ENSG00000082146 1490.481516 -0.540022903 2.21E-06 0.000530478 ROR2 ENSG00000169071 51.66428196 1.330114729 2.26E-06 0.000535573 WDR62 ENSG00000075702 392.4583356 0.742685063 2.34E-06 0.000548533 BOP1 ENSG00000261236 2717.668028 0.568242844 2.47E-06 0.000573116 ABCB9 ENSG00000150967 310.3422343 1.043991035 2.54E-06 0.000580868 TOR4A ENSG00000198113 1808.300782 0.783137846 2.57E-06 0.000583125 CHTF18 ENSG00000127586 1483.546963 0.533685124 2.81E-06 0.000630057 COMTD1 ENSG00000165644 627.0484613 0.683527265 2.98E-06 0.000653651 LAGE3 ENSG00000196976 547.9831232 0.774066071 3.75E-06 0.000795389 CDC34 ENSG00000099804 2104.092623 0.561084085 3.81E-06 0.000800381 PPIF ENSG00000108179 4048.185153 0.897431599 4.04E-06 0.000830413 SHISA8 ENSG00000234965 84.59587447 1.102519119 4.10E-06 0.000834118 DPP7 ENSG00000176978 8645.968654 0.618804106 4.43E-06 0.000874575 FAM207A ENSG00000160256 1023.671321 0.580011237 4.45E-06 0.000874575 PPDPF ENSG00000125534 2705.683785 0.737663108 4.47E-06 0.000874575 SCRIB ENSG00000180900 5025.990115 0.515214196 4.59E-06 0.000880765 YPEL3 ENSG00000090238 7582.832844 0.632519576 4.96E-06 0.000941239 FAM98C ENSG00000130244 1609.778352 0.471972093 5.13E-06 0.000956721 ZFPM1 ENSG00000179588 1236.150698 0.797217941 5.78E-06 0.001056511 TGFB1 ENSG00000105329 22291.53085 0.539301982 6.11E-06 0.001096706 ARHGDIA ENSG00000141522 18357.90282 0.622391908 6.71E-06 0.001172903 BCL2L12 ENSG00000126453 653.6605763 0.612293264 6.67E-06 0.001172903 CPTP ENSG00000224051 1375.282205 0.651489521 6.89E-06 0.001174145 TMUB1 ENSG00000164897 2472.408526 0.534817695 6.85E-06 0.001174145 TMEM161A ENSG00000064545 829.133821 0.600747218 7.02E-06 0.001182149 SEMA4D ENSG00000187764 21105.7003 -0.490334476 7.63E-06 0.001236936 SNAI3 ENSG00000185669 1228.130742 0.697744305 7.54E-06 0.001236936 C9orf69 ENSG00000238227 1511.359617 1.089055555 7.60E-06 0.001236936

THAP7 ENSG00000184436 1214.936918 0.607451321 7.92E-06 0.001266128 BLOC1S4 ENSG00000186222 1082.918369 0.580707207 8.58E-06 0.001346323 JOSD2 ENSG00000161677 1209.673757 0.639916735 9.74E-06 0.001504884 GOLGA7B ENSG00000155265 1237.118725 -0.885584753 1.23E-05 0.001825133 PPTC7 ENSG00000196850 9018.734346 -0.376671495 1.25E-05 0.001836567 ZNF467 ENSG00000181444 2817.750593 0.713129674 1.29E-05 0.001880696 FSCN1 ENSG00000075618 283.7947798 0.808319926 1.35E-05 0.001933544 RRBP1 ENSG00000125844 5992.687798 0.486563009 1.41E-05 0.001981296 FA2H ENSG00000103089 60.14272609 1.165980684 1.45E-05 0.002025094 SLC25A20 ENSG00000178537 2946.065872 0.428868687 1.51E-05 0.002032165 RPS6KA4 ENSG00000162302 4325.809637 0.538299862 1.53E-05 0.002032165 ZNF837 ENSG00000152475 156.5201588 0.76315385 1.52E-05 0.002032165 TMEM175 ENSG00000127419 3795.451644 0.597403293 1.57E-05 0.002064151 CTB-50L17.10 ENSG00000167674 3013.74077 0.424007931 1.62E-05 0.002093379 PAK4 ENSG00000130669 704.0618626 0.49740594 1.65E-05 0.002127114 ZEB1 ENSG00000148516 2115.344699 -0.602204126 1.77E-05 0.002220442 C15orf61 ENSG00000189227 332.1370802 0.74918559 1.75E-05 0.002220442 RGS19 ENSG00000171700 8752.557296 0.594849809 1.77E-05 0.002220442 PPP1R16A ENSG00000160972 914.421507 0.641563135 1.80E-05 0.002243059 POP7 ENSG00000172336 850.8885463 0.60620918 1.84E-05 0.002272947 EMC6 ENSG00000127774 841.9271302 0.729995112 1.91E-05 0.002298475 MAP3K10 ENSG00000130758 1627.843434 0.610797409 2.01E-05 0.002386242 CHST13 ENSG00000180767 294.9987034 0.831491005 2.04E-05 0.0024007 SCX ENSG00000260428 91.93863432 0.945825262 2.08E-05 0.002436652 ZNF575 ENSG00000176472 176.3650544 0.716130007 2.09E-05 0.002436652 YIPF2 ENSG00000130733 1118.894238 0.598537518 2.15E-05 0.002490585 CCDC124 ENSG00000007080 2433.465227 0.531033449 2.17E-05 0.002496357 SF3A2 ENSG00000104897 3833.84824 0.417622747 2.19E-05 0.002507173 NAPRT ENSG00000147813 2483.87721 0.81592758 2.24E-05 0.002551709 TMEM259 ENSG00000182087 10792.74082 0.668840232 2.33E-05 0.002640077 NEK2 ENSG00000117650 76.25073023 1.042814928 2.38E-05 0.002645434 CNOT3 ENSG00000088038 5841.312 0.346654027 2.39E-05 0.002645434 MAF1 ENSG00000179632 7210.576241 0.594120481 2.60E-05 0.002829198 ZNF593 ENSG00000142684 429.5824018 0.698302218 2.89E-05 0.00311489 RPRD1A ENSG00000141425 2459.394418 -0.414741582 2.96E-05 0.003175265 CYBA ENSG00000051523 44945.96001 0.528173577 3.02E-05 0.003202563 ZNF385A ENSG00000161642 7921.937539 0.501561104 3.05E-05 0.003202563 PKN1 ENSG00000123143 20657.57499 0.479202879 3.10E-05 0.003234929 MOSPD3 ENSG00000106330 690.1465901 0.553238585 3.51E-05 0.003624887 RHBDD2 ENSG00000005486 2351.372346 0.67612226 3.54E-05 0.00364231 C2CD4D ENSG00000225556 41.78383742 1.089961289 3.57E-05 0.00365189 RAI1 ENSG00000108557 2721.868511 0.454220207 3.64E-05 0.003701753 REEP4 ENSG00000168476 2350.701231 0.543297591 3.85E-05 0.003873794 USF2 ENSG00000105698 12144.65974 0.343373464 3.96E-05 0.003948549 PGAM4 ENSG00000226784 225.4693422 0.634882652 4.17E-05 0.004062249 SSBP4 ENSG00000130511 8094.294575 0.503977141 4.12E-05 0.004062249

SPHK2 ENSG00000063176 1197.110627 0.443837531 4.10E-05 0.004062249 SDHAF1 ENSG00000205138 787.3957934 0.640548919 4.14E-05 0.004062249 C9orf16 ENSG00000171159 3332.506362 0.661941178 4.18E-05 0.004062249 GTF2F1 ENSG00000125651 5709.85371 0.356885772 4.50E-05 0.00432975 C19orf43 ENSG00000123144 11500.73135 0.499844124 4.69E-05 0.004434943 PNPLA2 ENSG00000177666 10133.67612 0.523999707 4.74E-05 0.004437729 DGAT1 ENSG00000185000 4106.084139 0.517905692 4.74E-05 0.004437729 RP1-241P17.4 ENSG00000228532 139.1928683 0.536602226 4.81E-05 0.004476991 BBC3 ENSG00000105327 1002.2384 0.686028418 5.27E-05 0.004817139 TMEM120B ENSG00000188735 2784.000889 0.871321646 5.51E-05 0.004937489 KHSRP ENSG00000088247 7727.269868 0.292156513 5.62E-05 0.004974987 EIF3G ENSG00000130811 15833.33742 0.446067792 5.66E-05 0.004990687 ANGPTL6 ENSG00000130812 213.229145 0.991530084 5.78E-05 0.005074746 ISOC2 ENSG00000063241 852.8036578 0.704143394 5.85E-05 0.00511547 DUSP23 ENSG00000158716 975.8388157 0.649421899 5.97E-05 0.005166136 CDIPT ENSG00000103502 2921.011799 0.601636002 5.99E-05 0.005166136 TNNT1 ENSG00000105048 379.2239804 1.052325592 6.03E-05 0.005184986 RUVBL2 ENSG00000183207 2751.019554 0.46942123 6.43E-05 0.005408341 NIPAL4 ENSG00000172548 65.89252507 -0.820899123 6.49E-05 0.005439725 AP5Z1 ENSG00000242802 5030.097926 0.422313068 6.62E-05 0.005518557 RAD54L ENSG00000085999 112.2434414 0.785426834 6.69E-05 0.005535745 RTN4R ENSG00000040608 97.8036758 0.86145085 6.73E-05 0.005544573 ARMC5 ENSG00000140691 860.9623694 0.665556707 6.93E-05 0.005681639 STRN4 ENSG00000090372 5935.79704 0.420284785 7.05E-05 0.005734745 OR52N4 ENSG00000181074 83.33276373 -0.8441178 7.16E-05 0.005746473 RBM42 ENSG00000126254 3450.591652 0.506077628 7.18E-05 0.005746473 BORCS6 ENSG00000196544 1555.903995 0.615803355 7.18E-05 0.005746473 ZNF219 ENSG00000165804 375.5585941 0.639932559 7.10E-05 0.005746473 LRP5 ENSG00000162337 183.7007745 0.715043739 7.30E-05 0.005822253 EIF4EBP1 ENSG00000187840 1809.25141 0.617000144 7.39E-05 0.005846929 AGPAT2 ENSG00000169692 2019.559022 0.645796163 7.64E-05 0.005928347 RFNG ENSG00000169733 1599.046193 0.540782323 7.58E-05 0.005928347 POLG2 ENSG00000256525 3921.636601 -0.367515181 7.64E-05 0.005928347 MIER2 ENSG00000105556 1555.40582 0.372960012 7.99E-05 0.006076321 CXCL16 ENSG00000161921 3004.186791 0.638609388 7.98E-05 0.006076321 TBKBP1 ENSG00000198933 3109.08902 0.578067622 8.05E-05 0.006101359 NT5DC2 ENSG00000168268 683.1870332 0.790519268 8.28E-05 0.006253805 C16orf86 ENSG00000159761 325.2728641 0.499392258 8.38E-05 0.006303396 RECQL4 ENSG00000160957 542.8200083 0.684036463 8.42E-05 0.006308982 EFHD2 ENSG00000142634 43120.65331 0.528717134 8.47E-05 0.006321347 ZDHHC8 ENSG00000099904 2965.555875 0.555798205 8.51E-05 0.006327258 NDUFS7 ENSG00000115286 4333.45019 0.568833134 8.64E-05 0.006406051 TRMT61A ENSG00000166166 1088.467516 0.523090027 9.31E-05 0.006872995 TSR3 ENSG00000007520 1629.366207 0.536456995 9.39E-05 0.006904644 ACAP3 ENSG00000131584 6583.98326 0.491734794 9.60E-05 0.007036306 TAS2R20 ENSG00000255837 120.7267483 -0.598177958 9.76E-05 0.007102326

ATP5D ENSG00000099624 2041.880316 0.746213086 9.85E-05 0.007138743 ANKRD9 ENSG00000156381 339.3066621 0.852848703 0.000102928 0.007276159 PAQR4 ENSG00000162073 630.2069238 0.7630384 0.000102522 0.007276159 AURKB ENSG00000178999 187.9567542 0.786922226 0.000102856 0.007276159 SRSF10 ENSG00000188529 6415.873929 -0.689467214 0.000110705 0.00766284 ZBTB32 ENSG00000011590 436.2318755 0.740470144 0.000114553 0.007874548 DRAP1 ENSG00000175550 6670.897278 0.457797816 0.000117 0.007987632 GPAA1 ENSG00000197858 2959.965714 0.5341835 0.000116983 0.007987632 TNRC18 ENSG00000182095 11254.49418 0.436520852 0.000118921 0.008009095 ASB2 ENSG00000100628 363.4453616 0.622864384 0.00011823 0.008009095 HSF1 ENSG00000185122 4033.361778 0.493205027 0.000118812 0.008009095 SYTL1 ENSG00000142765 11788.75762 0.41221066 0.000118193 0.008009095 MZT2A ENSG00000173272 2314.298326 0.633261732 0.00012085 0.008089621 GPSM1 ENSG00000160360 377.166653 0.609275827 0.000122552 0.008089621 KMT5C ENSG00000133247 838.9864561 0.583057586 0.000122075 0.008089621 TESK1 ENSG00000107140 3567.015472 0.438909954 0.000122363 0.008089621 BSG ENSG00000172270 15502.82003 0.514737675 0.000121672 0.008089621 NCDN ENSG00000020129 1816.552574 0.373450912 0.000124875 0.008161929 MZB1 ENSG00000170476 2011.624959 0.933505092 0.000124552 0.008161929 ATPIF1 ENSG00000130770 4211.911435 0.373955586 0.000126536 0.008243418 TMEM53 ENSG00000126106 329.0689286 0.390719991 0.000128078 0.008297899 PKMYT1 ENSG00000127564 148.7936916 0.968816802 0.000131316 0.008471825 PIAS4 ENSG00000105229 2238.841209 0.355801086 0.000132661 0.008530942 ACOT7 ENSG00000097021 709.9103048 0.575694974 0.000133301 0.008544524 EFHC2 ENSG00000183690 370.8161513 -0.619184718 0.000134378 0.008585989 MFSD10 ENSG00000109736 4334.484128 0.590555214 0.000136638 0.008702502 CITED2 ENSG00000164442 5212.928152 0.85752968 0.000137287 0.008715958 EXOSC4 ENSG00000178896 447.5099264 0.596671776 0.000138328 0.008731387 MBLAC1 ENSG00000214309 67.24516731 0.86768912 0.000138406 0.008731387 DRD4 ENSG00000069696 29.53393703 0.971897 0.000139411 0.008767089 PTTG1 ENSG00000164611 600.2627528 0.643163881 0.000141816 0.008862369 CLEC11A ENSG00000105472 309.8047881 0.888277618 0.000150128 0.009323342 TPX2 ENSG00000088325 488.4194121 0.830722486 0.000150623 0.009325044 SLC35A3 ENSG00000117620 2876.93582 -0.700650923 0.000152714 0.009345988 AURKAIP1 ENSG00000175756 2310.542426 0.517521358 0.000152667 0.009345988 ADCK1 ENSG00000063761 1001.169611 0.366188439 0.000156585 0.009506778 SLC39A4 ENSG00000147804 347.6650792 0.655954078 0.000156896 0.009506778 JCHAIN ENSG00000132465 25855.31515 0.936352754 0.000158014 0.009545456 BAD ENSG00000002330 1159.296669 0.637253585 0.000166322 0.00991829 RAB11B ENSG00000185236 6746.121463 0.508985765 0.000167558 0.00991829 CLTB ENSG00000175416 3019.102641 0.523149318 0.000167668 0.00991829 ADRB1 ENSG00000043591 65.83621857 0.935649525 0.000167533 0.00991829 ZFP28 ENSG00000196867 501.1712332 -0.519518852 0.000165789 0.00991829 ANKRD13D ENSG00000172932 15520.85407 0.376011126 0.000169798 0.009926446 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 14. Significantly differential expressed genes in the comparison of CHB with NC

log2FoldChange P-value Gene Symbol Ensembl ID baseMean P-valuea (CHB/NC) adjustedb

CEBPB ENSG00000172216 2972.489923 1.638264421 1.42E-13 1.33E-09 SCAF4 ENSG00000156304 6801.011991 0.496266837 1.06E-11 6.58E-08 LRRN3 ENSG00000173114 738.6130444 -1.183393197 1.13E-09 3.51E-06 SERTAD2 ENSG00000179833 6745.599018 0.720159461 5.61E-09 1.49E-05 CCDC173 ENSG00000154479 152.2415973 1.513367357 7.70E-08 0.000130621 MEF2D ENSG00000116604 10721.90548 0.724854887 1.19E-07 0.00017135 ZNF226 ENSG00000167380 1244.659454 -0.769726872 1.88E-07 0.000195201 SDE2 ENSG00000143751 3242.394139 0.837155428 2.19E-07 0.000207622 PIGA ENSG00000165195 2669.449213 0.747114655 2.88E-07 0.00024446 BEND5 ENSG00000162373 142.626799 -0.91567285 3.14E-07 0.00025517 PPIL1 ENSG00000137168 691.8680435 -0.741251065 4.92E-07 0.000367481 GEMIN2 ENSG00000092208 345.9390379 -0.451771019 6.92E-07 0.000461519 C4orf48 ENSG00000243449 71.38095532 1.430701243 6.49E-07 0.000461519 ZBTB10 ENSG00000205189 1150.309229 0.839375405 7.46E-07 0.000475862 PLRG1 ENSG00000171566 2987.9049 -0.423113012 8.16E-07 0.000475862 AKIRIN2 ENSG00000135334 5020.23332 0.594923715 9.42E-07 0.000527298 MAFK ENSG00000198517 2221.285355 0.805888948 1.23E-06 0.00060189 CX3CR1 ENSG00000168329 12808.32106 -1.065055697 1.20E-06 0.00060189 MNT ENSG00000070444 4495.540743 0.506587503 1.17E-06 0.00060189 SBDS ENSG00000126524 6946.057478 0.847721693 1.42E-06 0.000646361 CHIC2 ENSG00000109220 2322.994232 0.639116756 1.64E-06 0.000660673 ATF3 ENSG00000162772 579.7646122 1.223596605 1.58E-06 0.000660673 MRPL15 ENSG00000137547 1113.91083 -0.429865043 1.58E-06 0.000660673 NDUFA8 ENSG00000119421 1009.265348 -0.536413085 1.82E-06 0.000694598 ZNF385A ENSG00000161642 7422.066569 0.549142288 2.15E-06 0.000756204 RNF166 ENSG00000158717 28399.20328 0.427561997 2.48E-06 0.00078587 OGFOD1 ENSG00000087263 1853.710955 -0.464713495 2.57E-06 0.000786642 DUSP8 ENSG00000184545 993.7674401 1.104855374 2.66E-06 0.000787618 GCSAM ENSG00000174500 922.9990683 -0.893160841 2.87E-06 0.000808515 YOD1 ENSG00000180667 3787.131969 0.698833533 2.82E-06 0.000808515 IL16 ENSG00000172349 15689.09085 -0.56381074 2.88E-06 0.000808515 MAT2B ENSG00000038274 8889.290545 -0.592126251 3.21E-06 0.000869562 GIMAP7 ENSG00000179144 7569.963984 -1.029816882 3.33E-06 0.000875077 ARCN1 ENSG00000095139 5922.881103 -0.687052622 3.53E-06 0.000903418 CXCR6 ENSG00000172215 264.0035645 -1.090092998 3.73E-06 0.000922761 ACTL6A ENSG00000136518 1867.920249 -0.426456168 3.86E-06 0.000924803 LXN ENSG00000079257 308.6029594 -0.643391111 3.86E-06 0.000924803 PPIF ENSG00000108179 3439.751464 0.744756286 3.92E-06 0.000926136 POP1 ENSG00000104356 297.4346501 -0.793479182 4.12E-06 0.000960719 FAM50B ENSG00000145945 192.376806 -0.769524381 4.25E-06 0.000975736 TNFRSF12A ENSG00000006327 144.7239674 1.138653912 4.29E-06 0.000975736 TWNK ENSG00000107815 590.0675584 -0.759175901 5.00E-06 0.001072263

DVL3 ENSG00000161202 6644.528216 0.234918046 4.83E-06 0.001072263 TRMT12 ENSG00000183665 715.3258513 -0.51404827 4.89E-06 0.001072263 CNIH2 ENSG00000174871 132.0695344 0.95782558 5.10E-06 0.00108203 CD40LG ENSG00000102245 2313.331566 -0.70413464 5.28E-06 0.001100621 ZNF501 ENSG00000186446 116.7855018 -1.051951614 5.94E-06 0.001191897 ORC5 ENSG00000164815 810.859597 -0.443262059 6.21E-06 0.001219375 UTP6 ENSG00000108651 3856.22803 -0.416497254 6.62E-06 0.001274841 TSPAN5 ENSG00000168785 833.7555927 -0.496268567 7.07E-06 0.001333412 KLF11 ENSG00000172059 6765.95763 0.724443212 7.41E-06 0.00135101 GEMIN6 ENSG00000152147 488.3774749 -0.711255773 7.29E-06 0.00135101 RHBDL1 ENSG00000103269 110.3634206 0.956951637 7.45E-06 0.00135101 EAF1 ENSG00000144597 1336.789463 0.628760522 8.31E-06 0.001476496 TUBD1 ENSG00000108423 585.3042662 -0.437287735 1.02E-05 0.001662591 GPR55 ENSG00000135898 636.4922211 -0.769749847 1.01E-05 0.001662591 GRIN2C ENSG00000161509 198.7915567 0.943316856 1.10E-05 0.001791286 CCIN ENSG00000185972 41.99417641 1.163150795 1.16E-05 0.001831354 AVPR2 ENSG00000126895 550.4851514 0.752870449 1.16E-05 0.001831354 MSH2 ENSG00000095002 1797.041241 -0.573180863 1.21E-05 0.001878738 ALDH1A2 ENSG00000128918 99.98621497 1.209620494 1.42E-05 0.002096433 HNRNPF ENSG00000169813 13016.50376 -0.478029314 1.57E-05 0.002235502 GBP1 ENSG00000117228 5722.013003 -0.738294767 1.63E-05 0.002239355 MED11 ENSG00000161920 879.8958755 -0.525043053 1.62E-05 0.002239355 AKTIP ENSG00000166971 2328.721627 -0.532228818 1.66E-05 0.002257769 FAM46A ENSG00000112773 4353.297179 0.667534767 1.89E-05 0.002542391 CORO6 ENSG00000167549 310.6872391 0.593226313 2.00E-05 0.002653076 HES4 ENSG00000188290 138.1521471 1.080683201 2.03E-05 0.002667181 SFPQ ENSG00000116560 21626.59525 0.418996871 2.14E-05 0.002731886 MIDN ENSG00000167470 12000.69348 0.552625657 2.13E-05 0.002731886 PRKCSH ENSG00000130175 15742.7127 0.375554055 2.24E-05 0.002821663 CISH ENSG00000114737 1622.001741 -0.899924953 2.40E-05 0.002984923 SLC35F2 ENSG00000110660 561.7100515 -0.454581259 2.57E-05 0.003160156 ZNF681 ENSG00000196172 368.5511239 -0.734429898 2.62E-05 0.003168934 HCCS ENSG00000004961 745.9881835 -0.473989129 2.71E-05 0.003168934 ZNF285 ENSG00000267508 148.9419491 -0.825341921 2.71E-05 0.003168934 COA4 ENSG00000181924 1498.718008 -0.305908142 2.65E-05 0.003168934 MYO15B ENSG00000266714 18287.5453 0.502907269 2.67E-05 0.003168934 CDK16 ENSG00000102225 3925.227261 0.592243296 2.81E-05 0.003236397 CD180 ENSG00000134061 1275.44628 -0.841391636 2.89E-05 0.003313959 ALDH6A1 ENSG00000119711 880.5857982 -0.466405958 3.00E-05 0.003400148 UGP2 ENSG00000169764 6626.872486 -0.365823541 3.08E-05 0.003438043 SLC30A1 ENSG00000170385 3329.362481 0.569898213 3.13E-05 0.003458762 ARRDC4 ENSG00000140450 3676.812421 0.763774775 3.21E-05 0.003526657 TARS2 ENSG00000143374 1935.21123 -0.351353187 3.23E-05 0.003526657 NUDCD1 ENSG00000120526 808.9032282 -0.517305956 3.40E-05 0.003664808 STIP1 ENSG00000168439 4872.398468 -0.477362898 3.49E-05 0.003719149 JRKL ENSG00000183340 904.3466649 -0.790747005 3.47E-05 0.003719149

GEMIN5 ENSG00000082516 957.7499557 -0.473400319 3.55E-05 0.003761888 QRSL1 ENSG00000130348 1868.191797 -0.40648093 3.74E-05 0.003897039 CETN3 ENSG00000153140 436.0157592 -0.699075242 3.85E-05 0.003907965 SMARCD3 ENSG00000082014 3526.65134 0.477717397 3.81E-05 0.003907965 PARP1 ENSG00000143799 10307.87733 -0.358733036 3.81E-05 0.003907965 PGBD2 ENSG00000185220 699.1644417 -0.792652351 3.81E-05 0.003907965 ARMCX2 ENSG00000184867 279.7288261 -0.541718823 4.08E-05 0.004051698 NR4A2 ENSG00000153234 3529.926598 0.969317558 4.10E-05 0.004051698 C1orf74 ENSG00000162757 1090.493042 -0.77920951 4.33E-05 0.004230378 TIPARP ENSG00000163659 4136.292906 0.725441987 4.42E-05 0.004295853 RGCC ENSG00000102760 4119.032885 0.681549261 4.62E-05 0.004402395 TTC9B ENSG00000174521 41.81019541 1.056890771 4.65E-05 0.004403068 THNSL1 ENSG00000185875 233.5223868 -0.776746778 5.19E-05 0.00472305 CD160 ENSG00000117281 1175.673873 -0.73449832 5.29E-05 0.004771203 FAM83D ENSG00000101447 129.945875 0.708186271 5.87E-05 0.005140329 PPP1R15B ENSG00000158615 13285.09658 0.390096538 6.07E-05 0.005198362 HPS5 ENSG00000110756 1863.806549 -0.470414527 6.13E-05 0.005227784 CASZ1 ENSG00000130940 1255.537087 0.472292579 6.36E-05 0.005324349 CA14 ENSG00000118298 139.2222215 0.851180238 6.44E-05 0.005367211 MCM3 ENSG00000112118 4084.818891 -0.359042379 6.51E-05 0.005401134 FBRS ENSG00000156860 9446.021907 0.433845088 6.66E-05 0.005479807 PARM1 ENSG00000169116 462.9946633 -0.556100985 6.66E-05 0.005479807 BRD8 ENSG00000112983 3440.080635 -0.461994232 6.78E-05 0.005526961 FAM220A ENSG00000178397 829.1791424 -0.484658497 6.81E-05 0.005529578 ACAP3 ENSG00000131584 5905.223692 0.425819758 6.90E-05 0.005573418 C12orf49 ENSG00000111412 2707.025015 -0.39989492 7.40E-05 0.005879667 ISCA1 ENSG00000135070 5120.765027 0.533252824 7.40E-05 0.005879667 ARL8A ENSG00000143862 4883.892623 0.435592247 7.44E-05 0.005884454 CD79B ENSG00000007312 2982.650405 -0.658896836 7.53E-05 0.005931795 KDM8 ENSG00000155666 383.2403802 -0.627885101 7.93E-05 0.006195387 GLTSCR1 ENSG00000063169 2454.750058 0.425079834 8.02E-05 0.006219336 PDE8A ENSG00000073417 3865.241551 0.309364443 8.54E-05 0.006483804 LBH ENSG00000213626 13053.52056 -0.633033337 8.58E-05 0.006483992 RWDD2B ENSG00000156253 583.800629 -0.519102189 8.85E-05 0.006632496 TMEM160 ENSG00000130748 338.5634709 0.893789216 9.30E-05 0.00692101 SLC39A14 ENSG00000104635 503.295024 -0.469100592 9.32E-05 0.00692101 MGAT2 ENSG00000168282 1899.91102 -0.603280103 9.43E-05 0.006957849 ZNF415 ENSG00000170954 113.2769553 -0.818561417 0.000101691 0.00732921 SIK1 ENSG00000142178 3237.682491 0.907265904 0.000101418 0.00732921 NEK9 ENSG00000119638 8735.728701 -0.363623679 0.000102704 0.007373786 CMTR2 ENSG00000180917 2188.991072 -0.642063371 0.000104678 0.007461305 RELA ENSG00000173039 7467.306169 0.448023506 0.000104723 0.007461305 GDF11 ENSG00000135414 1261.640303 -0.466550089 0.00010675 0.007528558 ZNF582 ENSG00000018869 256.3101729 -0.499349165 0.000110632 0.007699668 YBX3 ENSG00000060138 4037.393775 0.492420201 0.000110956 0.007699668 SUPT16H ENSG00000092201 8755.823275 -0.292861294 0.000114936 0.007859033

LINGO2 ENSG00000174482 116.0997899 -1.041516178 0.000119514 0.008107996 CXCL16 ENSG00000161921 2801.037614 0.655020363 0.000123608 0.008270199 SAMD9 ENSG00000205413 5707.704381 -0.608291002 0.000126477 0.008372132 ACTR6 ENSG00000075089 1399.40578 -0.373220013 0.000127194 0.008389863 C16orf87 ENSG00000155330 1077.697165 0.569183256 0.000132886 0.008637826 KIF1BP ENSG00000198954 774.6651145 -0.429762527 0.000133267 0.008637826 BCL2 ENSG00000171791 6603.660168 -0.41690071 0.000135113 0.008727162 TARS ENSG00000113407 3395.623135 -0.328535181 0.000136871 0.008749927 TRIM11 ENSG00000154370 3754.617189 0.357238568 0.000136373 0.008749927 LCMT2 ENSG00000168806 295.185901 -0.650328128 0.000138697 0.008806333 MED30 ENSG00000164758 2348.434831 0.584865884 0.000141453 0.00884382 FOXO3 ENSG00000118689 5746.251302 0.436521866 0.000145887 0.008899602 BTG3 ENSG00000154640 1011.681772 0.834051906 0.000145624 0.008899602 GGPS1 ENSG00000152904 2216.82834 -0.433934154 0.000147183 0.008920359 SUPV3L1 ENSG00000156502 2346.710774 0.478365228 0.000150089 0.009037784 AGMAT ENSG00000116771 310.6587626 -0.549189422 0.000152217 0.009136469 CDK4 ENSG00000135446 1497.158304 -0.488375959 0.000157189 0.009315064 ZNF598 ENSG00000167962 3323.842875 0.386625723 0.000161092 0.009516147 MAGEH1 ENSG00000187601 787.5203404 -0.483753449 0.000162067 0.009543524 SWAP70 ENSG00000133789 4208.937149 -0.353308426 0.000163702 0.009579368 RP11-345J4.3 ENSG00000258150 96.24271872 0.665364515 0.000166902 0.009694091 COPB2 ENSG00000184432 7075.922938 -0.482635939 0.000168259 0.009694091 BOLA1 ENSG00000178096 274.54224 -0.652582966 0.000169554 0.009738662 RPL7L1 ENSG00000146223 3870.36983 -0.483799794 0.000170733 0.009746397 a P-value computed using DESeq2 b Adjusted P value calculated using the Benjamini and Hochberg procedure significance was defined as‘P-value <0.05, adjusted P-value <0.01

Supplementary Table 15. The allocation map of general biological process

Theme GO Term Description Term size P value Density Gene set type 2.00E-04 0.01499 LC vs. NC from 201 to 300 GO:0030950 establishment or maintenance of actin cytoskeleton polarity 11 0 0.01968 LC vs. NC from 251 to 350 GO:0032232 negative regulation of actin filament bundle assembly 19 0 0.01063 ACLF vs. NC from 1 to 100 5.00E-04 0.01141 ACLF vs. NC from 51 to 150 actin filament GO:0032233 positive regulation of actin filament bundle assembly 46 1.00E-04 0.01032 ACHD vs. NC from 201 to 300 3.00E-04 0.01042 ACHD vs. NC from 251 to 350 0 0.01616 ACHD vs. NC from 201 to 300 GO:0051014 actin filament severing 5 0 0.01649 LC vs. NC from 401 to 500 protein insertion into mitochondrial membrane involved in GO:0001844 6 1.00E-04 0.01202 CHB vs. NC from 101 to 200 apoptotic signalling pathway regulation of tumor necrosis factor-mediated GO:0010803 50 0 0.0107 CHB vs. NC from 301 to 400 signalling pathway 5.00E-04 0.01836 ACHD vs. NC from 251 to 350 0 0.0303 ACLF vs. NC from 1 to 100 GO:0051873 killing by host of symbiont cells 5 0 0.0303 ACLF vs. NC from 51 to 150 3.00E-04 0.02 ACLF vs. NC from 101 to 200 GO:0060544 regulation of necroptotic process 11 7.00E-04 0.01101 CHB vs. NC from 301 to 400 GO:0060561 apoptotic process involved in morphogenesis 3 7.00E-04 0.02061 CHB vs. NC from 101 to 200 6.00E-04 0.02332 ACLF vs. NC from 251 to 350 GO:0071550 death-inducing signalling complex assembly 7 0 0.02308 CHB vs. NC from 301 to 400 9.00E-04 0.01714 CHB vs. NC from 351 to 450 0 0.02188 ACHD vs. NC from 201 to 300 GO:0097527 necroptotic signalling pathway 6 0 0.0221 ACHD vs. NC from 251 to 350 negative regulation of intrinsic apoptotic signalling GO:1902254 15 9.00E-04 0.0101 CHB vs. NC from 201 to 300 pathway by p53 class mediator 2.00E-04 0.0102 ACHD vs. NC from 251 to 350 apoptosis inhibition of cysteine-type endopeptidase activity involved 3.00E-04 0.0102 ACLF vs. NC from 251 to 350 GO:1990001 7 in apoptotic process 0 0.01443 CHB vs. NC from 301 to 400 0 0.01142 CHB vs. NC from 351 to 450

protein insertion into mitochondrial membrane involved in GO:0001844 6 2.00E-04 0.0101 CHB vs. NC from 51 to 150 apoptotic signalling pathway positive regulation of protein insertion into mitochondrial GO:1900740 23 9.00E-04 0.0163 LC vs. NC from 351 to 450 membrane involved in apoptotic signalling pathway positive regulation of mitochondrial outer membrane GO:1901030 30 0.001 0.01388 LC vs. NC from 351 to 450 permeabilization involved in apoptotic signalling pathway GO:0051715 cytolysis in other organism 7 4.00E-04 0.01311 LC vs. NC from 1 to 00 cytolysis in other organism involved in symbiotic GO:0051801 4 1.00E-04 0.02295 LC vs. NC from 1 to 00 interaction GO:0051838 cytolysis by host of symbiont cells 1 0 0.0707 ACLF vs. NC from 1 to 100 GO:0019835 cytolysis 10 7.00E-04 0.0101 ACLF vs. NC from 1 to 100 0 0.02164 ACLF vs. NC from 1 to 100 0 0.02164 ACLF vs. NC from 51 to 150 GO:0051852 disruption by host of symbiont cells 7 4.00E-04 0.01428 ACLF vs. NC from 101 to 200 6.00E-04 0.01311 ACHD vs. NC from 351 to 450 GO:0035635 entry of bacterium into host cell 8 8.00E-04 0.0404 ACHD vs. NC from 201 to 300 0 0.0404 ACLF vs. NC from 1 to 100 GO:0070944 neutrophil mediated killing of bacterium 3 0 0.03703 ACLF vs. NC from 51 to 150 bacterium-related 0 0.0606 ACLF vs. NC from 1 to 100 GO:0070945 neutrophil mediated killing of gram-negative bacterium 2 0 0.0505 ACLF vs. NC from 51 to 150 GO:0071726 cellular response to diacyl bacterial lipopeptide 4 0.001 0.0101 ACHD vs. NC from 201 to 300 GO:0002091 negative regulation of receptor internalization 7 6.00E-04 0.01749 ACHD vs. NC from 251 to 350 6.00E-04 0.01117 ACLF vs. NC from 51 to 150 GO:0090175 regulation of establishment of planar polarity 47 0 0.01063 ACLF vs. NC from 251 to 350 establishment or maintenance of epithelial cell apical/basal 0 0.01359 ACHD vs. NC from 201 to 300 GO:0045197 26 polarity 0 0.01373 ACHD vs. NC from 251 to 350 0 0.01219 ACHD vs. NC from 201 to 300 GO:0035088 establishment or maintenance of apical/basal cell polarity 29 1.00E-04 0.01231 ACHD vs. NC from 251 to 350 GO:0035089 establishment of apical/basal cell polarity 13 0.001 0.01334 ACHD vs. NC from 151 to 250 GO:1901739 regulation of myoblast fusion 14 2.00E-04 0.01178 LC vs. NC from 251 to 350 GO:1901741 positive regulation of myoblast fusion 12 0 0.01374 LC vs. NC from 251 to 350

4.00E-04 0.01727 ACLF vs. NC from 101 to 200 GO:0045198 establishment of epithelial cell apical/basal polarity 11 5.00E-04 0.01576 ACHD vs. NC from 151 to 250 5.00E-04 0.01652 ACHD vs. NC from 201 to 300 0 0.0102 ACLF vs. NC from 151 to 250 cell activity GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 12 0 0.01041 ACLF vs. NC from 201 to 300 GO:0002092 positive regulation of receptor internalization 22 2.00E-04 0.01239 ACLF vs. NC from 51 to 150 positive regulation of syncytium formation by plasma 0 0.01159 LC vs. NC from 251 to 350 GO:0060143 16 membrane fusion 6.00E-04 0.0103 LC vs. NC from 301 to 400 5.00E-04 0.0101 ACLF vs. NC from 1 to 100 GO:0034382 chylomicron remnant clearance 6 6.00E-04 0.0101 ACLF vs. NC from 51 to 150 entry of symbiont into host cell by promotion of host GO:0052066 1 3.00E-04 0.04081 ACLF vs. NC from 151 to 250 phagocytosis GO:0052405 negative regulation by host of symbiont molecular function 6 5.00E-04 0.01041 ACLF vs. NC from 201 to 300 GO:0048210 Golgi vesicle fusion to target membrane 3 7.00E-04 0.0238 ACLF vs. NC from 251 to 350 GO:0048550 negative regulation of pinocytosis 5 2.00E-04 0.01616 ACHD vs. NC from 51 to 150 GO:0045806 negative regulation of endocytosis 41 0 0.0102 ACHD vs. NC from 251 to 350 GO:0090179 planar cell polarity pathway involved in neural tube closure 3 6.00E-04 0.03125 ACLF vs. NC from 201 to 300 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration 2 1.00E-04 0.03061 ACLF vs. NC from 151 to 250 4.00E-04 0.02333 ACLF vs. NC from 101 to 200 GO:0007161 calcium-independent cell-matrix adhesion 3 1.00E-04 0.0238 ACLF vs. NC from 151 to 250 0 0.01021 ACHD vs. NC from 201 to 300 GO:0022409 positive regulation of cell-cell adhesion 182 0 0.01042 ACHD vs. NC from 251 to 350 0 0.01166 ACLF vs. NC from 101 to 200 cell adhesion GO:0033627 cell adhesion mediated by integrin 18 0 0.01927 ACLF vs. NC from 151 to 250 0 0.01099 ACLF vs. NC from 201 to 300 GO:0034113 heterotypic cell-cell adhesion 23 0 0.01153 ACLF vs. NC from 151 to 250 bundle of His cell-Purkinje myocyte adhesion involved in 4.00E-04 0.01041 ACLF vs. NC from 201 to 300 GO:0086073 6 cell communication 2.00E-04 0.0119 ACLF vs. NC from 251 to 350 positive regulation of substrate adhesion-dependent cell 7.00E-04 0.01111 ACLF vs. NC from 201 to 300 GO:1900026 30 spreading 4.00E-04 0.01279 ACHD vs. NC from 201 to 300 0 0.01167 CHB vs. NC from 51 to 150 GO:0033260 nuclear DNA replication 32 0 0.01224 CHB vs. NC from 101 to 200

4.00E-04 0.01166 LC vs. NC from 351 to 450 GO:1904353 regulation of telomere capping 25 1.00E-04 0.0169 LC vs. NC from 401 to 500 GO:1904355 positive regulation of telomere capping 17 0 0.02061 LC vs. NC from 401 to 500 positive regulation of telomere maintenance via telomere 0 0.01133 LC vs. NC from 351 to 450 GO:1904358 34 lengthening 1.00E-04 0.01516 LC vs. NC from 401 to 500 0 0.01375 CHB vs. NC from 1 to 100 GO:0007004 telomere maintenance via telomerase 24 0 0.0143 CHB vs. NC from 51 to 150 0 0.01561 CHB vs. NC from 51 to 150 GO:0032201 telomere maintenance via semi-conservative replication 22 6.00E-04 0.01405 CHB vs. NC from 101 to 200 1.00E-04 0.01045 CHB vs. NC from 351 to 450 0 0.01063 LC vs. NC from 351 to 450 GO:0032206 positive regulation of telomere maintenance 48 0 0.01288 LC vs. NC from 401 to 500 0 0.01204 LC vs. NC from 351 to 450 GO:0032212 positive regulation of telomere maintenance via telomerase 32 0 0.0161 LC vs. NC from 401 to 500 0 0.01187 CHB vs. NC from 1 to 100 GO:0010833 telomere maintenance via telomere lengthening 32 0 0.01199 CHB vs. NC from 51 to 150 GO:0006293 nucleotide-excision repair, preincision complex stabilization 20 3.00E-04 0.0106 CHB vs. NC from 51 to 150 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 36 0 0.01234 CHB vs. NC from 51 to 150 4.00E-04 0.01493 CHB vs. NC from 51 to 150 GO:0006297 nucleotide-excision repair, DNA gap filling 23 0.001 0.01086 CHB vs. NC from 351 to 450 GO:0006298 mismatch repair 26 0 0.01126 CHB vs. NC from 51 to 150 GO:0006301 postreplication repair 50 2.00E-04 0.0109 ACHD vs. NC from 51 to 150 GO:0006343 establishment of chromatin silencing 1 9.00E-04 0.04123 LC vs. NC from 251 to 350 GO:0022616 DNA strand elongation 22 0 0.01193 CHB vs. NC from 51 to 150 GO:0000012 single strand break repair 6 6.00E-04 0.0101 CHB vs. NC from 51 to 150 GO:0000715 nucleotide-excision repair, DNA damage recognition 23 0 0.01217 CHB vs. NC from 351 to 450 cell cycle GO:0043388 positive regulation of DNA binding 38 5.00E-04 0.0101 ACLF vs. NC from 1 to 100 GO:0000082 G1/S transition of mitotic cell cycle 100 0 0.01195 CHB vs. NC from 101 to 200 GO:0000086 G2/M transition of mitotic cell cycle 109 3.00E-04 0.01097 LC vs. NC from 401 to 500 positive regulation of cyclin-dependent protein GO:0031659 serine/threonine kinase activity involved in G1/S transition 7 9.00E-04 0.02428 ACLF vs. NC from 101 to 200 of mitotic cell cycle

GO:0044839 cell cycle G2/M phase transition 110 6.00E-04 0.01087 LC vs. NC from 401 to 500 GO:0044843 cell cycle G1/S phase transition 101 0 0.01214 CHB vs. NC from 101 to 200 1.00E-04 0.01652 CHB vs. NC from 51 to 150 GO:0006265 DNA topological change 11 5.00E-04 0.0178 CHB vs. NC from 101 to 200 GO:0006268 DNA unwinding involved in DNA replication 6 7.00E-04 0.01333 CHB vs. NC from 351 to 450 3.00E-04 0.0202 CHB vs. NC from 51 to 150 GO:0006269 DNA replication, synthesis of RNA primer 3 0.001 0.02061 CHB vs. NC from 101 to 200 0 0.01211 LC vs. NC from 1 to 00 3.00E-04 0.01 CHB vs. NC from 1 to 100 GO:0006270 DNA replication initiation 16 1.00E-04 0.01073 CHB vs. NC from 51 to 150 0 0.01546 CHB vs. NC from 101 to 200 GO:0006271 DNA strand elongation involved in DNA replication 17 0 0.01069 CHB vs. NC from 51 to 150 0 0.01 CHB vs. NC from 1 to 100 GO:0032392 DNA geometric change 33 0 0.01163 CHB vs. NC from 51 to 150 0 0.01374 CHB vs. NC from 101 to 200 GO:0032508 DNA duplex unwinding 23 0 0.01273 CHB vs. NC from 51 to 150 GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle 3 1.00E-04 0.02405 LC vs. NC from 401 to 500 0 0.0136 ACHD vs. NC from 151 to 250 GO:0000022 mitotic spindle elongation 9 4.00E-04 0.01169 LC vs. NC from 101 to 200 GO:0044878 mitotic cytokinesis checkpoint 4 8.00E-04 0.01302 LC vs. NC from 351 to 450 GO:0051228 mitotic spindle disassembly 2 9.00E-04 0.03061 ACHD vs. NC from 151 to 250 3.00E-04 0.0153 ACHD vs. NC from 151 to 250 GO:0051256 mitotic spindle midzone assembly 8 8.00E-04 0.01315 LC vs. NC from 101 to 200 GO:1901673 regulation of mitotic spindle assembly 21 4.00E-04 0.01129 LC vs. NC from 401 to 500 0 0.01064 ACHD vs. NC from 1 to 100 GO:0000387 spliceosomal snRNP assembly 37 0 0.01594 CHB vs. NC from 1 to 100 0 0.01037 CHB vs. NC from 51 to 150 GO:0000730 DNA recombinase assembly 3 9.00E-04 0.01718 LC vs. NC from 151 to 250 GO:0006294 nucleotide-excision repair, preincision complex assembly 28 8.00E-04 0.01334 CHB vs. NC from 51 to 150 GO:0006337 nucleosome disassembly 19 1.00E-04 0.01263 CHB vs. NC from 1 to 100 GO:0010265 SCF complex assembly 6 2.00E-04 0.01515 ACHD vs. NC from 51 to 150

GO:0010592 positive regulation of lamellipodium assembly 13 4.00E-04 0.01334 ACLF vs. NC from 251 to 350 positive regulation of cytoplasmic mRNA processing body GO:0010606 5 3.00E-04 0.01263 LC vs. NC from 101 to 200 assembly GO:0022617 extracellular matrix disassembly 58 0 0.01132 ACLF vs. NC from 51 to 150 0 0.01262 ACHD vs. NC from 201 to 300 GO:0030032 lamellipodium assembly 24 5.00E-04 0.01105 ACHD vs. NC from 251 to 350 GO:0031274 positive regulation of pseudopodium assembly 11 7.00E-04 0.0102 ACHD vs. NC from 151 to 250 GO:0032232 negative regulation of actin filament bundle assembly 19 0 0.01063 ACLF vs. NC from 1 to 100 5.00E-04 0.01141 ACLF vs. NC from 51 to 150 GO:0032233 positive regulation of actin filament bundle assembly 46 1.00E-04 0.01032 ACHD vs. NC from 201 to 300 3.00E-04 0.01042 ACHD vs. NC from 251 to 350 GO:0032534 regulation of microvillus assembly 5 2.00E-04 0.01443 LC vs. NC from 401 to 500 GO:0032986 protein-DNA complex disassembly 21 0 0.01476 CHB vs. NC from 1 to 100 5.00E-04 0.01767 ACLF vs. NC from 1 to 100 GO:0034380 high-density lipoprotein particle assembly 12 7.00E-04 0.01599 ACLF vs. NC from 51 to 150 GO:0035617 stress granule disassembly 5 7.00E-04 0.01428 ACHD vs. NC from 151 to 250 GO:0043149 stress fiber assembly 12 0 0.02083 ACLF vs. NC from 101 to 200 8.00E-04 0.0119 ACHD vs. NC from 251 to 350 GO:0044854 plasma membrane raft assembly 6 4.00E-04 0.0119 ACHD vs. NC from 351 to 450 9.00E-04 0.01178 ACHD vs. NC from 401 to 500 regulation of RNA polymerase II transcriptional 4.00E-04 0.02203 CHB vs. NC from 51 to 150 GO:0045898 11 preinitiation complex assembly 0 0.01909 CHB vs. NC from 351 to 450 positive regulation of RNA polymerase II transcriptional 2.00E-04 0.0303 CHB vs. NC from 51 to 150 GO:0045899 7 preinitiation complex assembly 0 0.02571 CHB vs. NC from 351 to 450 cellular process 0 0.01311 ACLF vs. NC from 251 to 350 GO:0046847 filopodium assembly 14 8.00E-04 0.01082 ACHD vs. NC from 201 to 300 9.00E-04 0.01145 LC vs. NC from 51 to 150 RNA polymerase II transcriptional preinitiation complex GO:0051123 10 assembly 0 0.01789 LC vs. NC from 101 to 200 5.00E-04 0.01212 CHB vs. NC from 51 to 150 GO:0051131 chaperone-mediated protein complex assembly 16 0.001 0.01375 CHB vs. NC from 1 to 100 GO:0051228 mitotic spindle disassembly 2 9.00E-04 0.03061 ACHD vs. NC from 151 to 250 0 0.0136 ACHD vs. NC from 151 to 250 GO:0051255 spindle midzone assembly 9

GO:0051255 spindle midzone assembly 9 3.00E-04 0.01169 LC vs. NC from 101 to 200 3.00E-04 0.0153 ACHD vs. NC from 151 to 250 GO:0051256 mitotic spindle midzone assembly 8 8.00E-04 0.01315 LC vs. NC from 101 to 200 GO:0051292 nuclear pore complex assembly 9 1.00E-04 0.0101 CHB vs. NC from 301 to 400 GO:0051492 regulation of stress fiber assembly 57 5.00E-04 0.01098 ACLF vs. NC from 51 to 150 0.001 0.0131 ACLF vs. NC from 51 to 150 GO:0051496 positive regulation of stress fiber assembly 37 4.00E-04 0.01013 ACLF vs. NC from 201 to 300 8.00E-04 0.01092 ACHD vs. NC from 201 to 300 GO:0051497 negative regulation of stress fiber assembly 16 3.00E-04 0.01073 ACLF vs. NC from 1 to 100 GO:0065005 protein-lipid complex assembly 24 4.00E-04 0.01052 ACLF vs. NC from 1 to 100 6.00E-04 0.01428 ACHD vs. NC from 251 to 350 GO:0070836 caveola assembly 5 0.001 0.01212 ACHD vs. NC from 401 to 500 GO:0097107 postsynaptic density assembly 6 4.00E-04 0.01166 ACLF vs. NC from 351 to 450 GO:1901673 regulation of mitotic spindle assembly 21 4.00E-04 0.01129 LC vs. NC from 401 to 500 GO:1901888 regulation of cell junction assembly 70 0 0.0101 ACHD vs. NC from 201 to 300 GO:1903553 positive regulation of extracellular exosome assembly 4 9.00E-04 0.0204 ACHD vs. NC from 251 to 350 GO:1904837 beta-catenin-TCF complex assembly 27 1.00E-04 0.02367 CHB vs. NC from 101 to 200 1.00E-04 0.01414 ACLF vs. NC from 1 to 100 GO:1903142 positive regulation of establishment of endothelial barrier 5 1.00E-04 0.01616 ACLF vs. NC from 51 to 150 sequestering of transforming growth factor beta GO:0035583 2 1.00E-04 0.02525 ACLF vs. NC from 1 to 100 in extracellular matrix GO:1990114 RNA polymerase II core complex assembly 1 2.00E-04 0.0421 LC vs. NC from 101 to 200 GO:0035356 cellular triglyceride homeostasis 6 8.00E-04 0.0103 LC vs. NC from 251 to 350 GO:2000547 regulation of dendritic cell dendrite assembly 3 5.00E-04 0.0103 LC vs. NC from 151 to 250

GO:0003266 regulation of secondary heart field cardioblast proliferation 2 7.00E-04 0.02061 LC vs. NC from 251 to 350

positive regulation of cell proliferation by VEGF-activated GO:0038091 3 0 0.0303 ACHD vs. NC from 1 to 100 platelet derived growth factor receptor signalling pathway cell proliferation 1.00E-04 0.0101 ACLF vs. NC from 1 to 100 GO:0048661 positive regulation of smooth muscle cell proliferation 43 0 0.01104 ACLF vs. NC from 51 to 150 GO:0061469 regulation of type B pancreatic cell proliferation 5 0 0.01818 ACHD vs. NC from 51 to 150 GO:0070345 negative regulation of fat cell proliferation 5 3.00E-04 0.0125 LC vs. NC from 351 to 450

0 0.02002 ACLF vs. NC from 1 to 100 GO:0002223 stimulatory C-type lectin receptor signalling pathway 57 1.00E-04 0.01931 ACLF vs. NC from 51 to 150 0 0.0109 ACLF vs. NC from 1 to 100 GO:0007596 blood coagulation 251 0 0.0107 ACLF vs. NC from 51 to 150 0 0.01515 ACLF vs. NC from 1 to 100 GO:0007597 blood coagulation, intrinsic pathway 16 0 0.01262 ACLF vs. NC from 51 to 150 0 0.03535 ACLF vs. NC from 1 to 100 GO:0007598 blood coagulation, extrinsic pathway 4 0.001 0.02272 ACLF vs. NC from 51 to 150 8.00E-04 0.0202 ACHD vs. NC from 1 to 100 0 0.01073 ACLF vs. NC from 1 to 100 GO:0007599 hemostasis 255 0 0.01057 ACLF vs. NC from 51 to 150 7.00E-04 0.01616 ACHD vs. NC from 201 to 300 GO:0010543 regulation of platelet activation 25 3.00E-04 0.01673 ACHD vs. NC from 251 to 350 GO:0010755 regulation of plasminogen activation 12 0.001 0.0101 ACLF vs. NC from 1 to 100 GO:0010757 negative regulation of plasminogen activation 5 6.00E-04 0.01616 ACLF vs. NC from 51 to 150 GO:0030168 platelet activation 111 0 0.01465 ACHD vs. NC from 201 to 300 0 0.01279 ACLF vs. NC from 1 to 100 GO:0030193 regulation of blood coagulation 60 0 0.01127 ACLF vs. NC from 51 to 150 coagulation 0 0.01435 ACLF vs. NC from 1 to 100 GO:0030194 positive regulation of blood coagulation 19 1.00E-04 0.01116 ACLF vs. NC from 51 to 150 GO:0030195 negative regulation of blood coagulation 40 0 0.01161 ACLF vs. NC from 1 to 100 GO:0031639 plasminogen activation 7 3.00E-04 0.01285 ACLF vs. NC from 101 to 200 0 0.01325 ACLF vs. NC from 1 to 100 GO:0042730 fibrinolysis 16 2.00E-04 0.01073 ACLF vs. NC from 51 to 150 0 0.01081 ACLF vs. NC from 1 to 100 GO:0050817 coagulation 253 0 0.01062 ACLF vs. NC from 51 to 150 GO:0050819 negative regulation of coagulation 42 0 0.01106 ACLF vs. NC from 1 to 100 0 0.0202 ACLF vs. NC from 1 to 100 0 0.01683 ACLF vs. NC from 51 to 150 GO:0051917 regulation of fibrinolysis 12 0 0.01333 ACLF vs. NC from 101 to 200 5.00E-04 0.0119 ACHD vs. NC from 251 to 350 0 0.02132 ACLF vs. NC from 1 to 100 GO:0051918 negative regulation of fibrinolysis 9

GO:0051918 negative regulation of fibrinolysis 9 0 0.0202 ACLF vs. NC from 51 to 150 0 0.01725 ACLF vs. NC from 1 to 100 GO:0072378 blood coagulation, fibrin clot formation 24 0 0.01304 ACLF vs. NC from 51 to 150 GO:0090330 regulation of platelet aggregation 14 7.00E-04 0.02308 ACHD vs. NC from 201 to 300 0 0.01278 ACLF vs. NC from 251 to 350 transforming growth factor beta receptor signalling pathway GO:0007179 79 5.00E-04 0.01048 ACHD vs. NC from 1 to 100 regulation of epidermal growth factor receptor GO:0042058 66 2.00E-04 0.01128 ACLF vs. NC from 251 to 350 signalling pathway negative regulation of epidermal growth factor GO:0042059 34 2.00E-04 0.0147 ACLF vs. NC from 251 to 350 receptor signalling pathway GO:0048008 platelet-derived growth factor receptor signalling pathway 17 0 0.01604 ACHD vs. NC from 1 to 100 GO:0061041 regulation of wound healing 92 0 0.01021 ACLF vs. NC from 1 to 100 GO:0061045 negative regulation of wound healing 50 0 0.0109 ACLF vs. NC from 1 to 100 wound positive regulation of transforming growth factor beta GO:0071636 8 5.00E-04 0.0101 ACLF vs. NC from 51 to 150 production negative regulation of cell migration involved in sprouting 9.00E-04 0.01398 ACLF vs. NC from 51 to 150 GO:0090051 13 angiogenesis 4.00E-04 0.01153 ACLF vs. NC from 101 to 200 negative regulation of transforming growth factor GO:1901389 1 7.00E-04 0.09 CHB vs. NC from 1 to 100 beta activation negative regulation of cellular response to transforming GO:1903845 growth factor beta stimulus 53 0 0.01039 ACLF vs. NC from 251 to 350 GO:1905906 regulation of amyloid fibril formation 8 1.00E-04 0.01641 ACLF vs. NC from 51 to 150 GO:0051918 negative regulation of fibrinolysis 9 2.00E-04 0.01555 ACLF vs. NC from 101 to 200 GO:0010934 macrophage cytokine production 1 9.00E-04 0.04123 LC vs. NC from 251 to 350 GO:0019058 viral life cycle 97 0 0.01103 ACLF vs. NC from 51 to 150 GO:0019064 fusion of virus membrane with host plasma membrane 6 8.00E-04 0.01346 ACHD vs. NC from 1 to 100 GO:0019068 virion assembly 37 0 0.01037 ACHD vs. NC from 1 to 100 GO:0019079 viral genome replication 24 5.00E-04 0.01041 ACLF vs. NC from 101 to 200 GO:0019086 late viral transcription 4 4.00E-04 0.01804 LC vs. NC from 251 to 350 GO:0030851 granulocyte differentiation 9 2.00E-04 0.0103 LC vs. NC from 251 to 350 GO:0039694 viral RNA genome replication 12 7.00E-04 0.01052 LC vs. NC from 101 to 200 8.00E-04 0.01683 ACLF vs. NC from 1 to 100 GO:0043921 modulation by host of viral transcription 27 2.00E-04 0.01459 ACHD vs. NC from 1 to 100 0 0.01259 CHB vs. NC from 1 to 100 virus

virus 0 0.0202 ACLF vs. NC from 1 to 100 GO:0043923 positive regulation by host of viral transcription 17 7.00E-04 0.01411 CHB vs. NC from 1 to 100 GO:0046718 viral entry into host cell 23 1.00E-04 0.0101 ACLF vs. NC from 51 to 150 positive regulation by virus of viral protein levels in host GO:0046726 4 4.00E-04 0.01546 LC vs. NC from 201 to 300 cell 1.00E-04 0.01274 ACLF vs. NC from 1 to 100 GO:0046782 regulation of viral transcription 42 5.00E-04 0.01082 ACHD vs. NC from 1 to 100 6.00E-04 0.01827 ACLF vs. NC from 1 to 100 GO:0050434 positive regulation of viral transcription 21 2.00E-04 0.01285 CHB vs. NC from 1 to 100 2.00E-04 0.02754 ACHD vs. NC from 1 to 100 GO:0075733 intracellular transport of virus 11 1.00E-04 0.02436 LC vs. NC from 201 to 300 GO:1902188 positive regulation of viral release from host cell 15 4.00E-04 0.01099 LC vs. NC from 401 to 500 biosynthetic process of antibacterial peptides active against 1.00E-04 0.0505 ACLF vs. NC from 1 to 100 GO:0002812 1 Gram-negative bacteria 0 0.0606 ACLF vs. NC from 51 to 150 GO:0005979 regulation of glycogen biosynthetic process 21 8.00E-04 0.01394 ACHD vs. NC from 1 to 100 GO:0005999 xylulose biosynthetic process 2 0.001 0.02083 ACHD vs. NC from 251 to 350 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 4 5.00E-04 0.0153 CHB vs. NC from 151 to 250 GO:0006108 malate metabolic process 7 0 0.0102 ACHD vs. NC from 251 to 350 GO:0006182 cGMP biosynthetic process 9 0 0.0101 ACHD vs. NC from 251 to 350 0 0.0132 CHB vs. NC from 1 to 100 GO:0006278 RNA-dependent DNA biosynthetic process 25 0 0.01373 CHB vs. NC from 51 to 150 GO:0007179 transforming growth factor beta receptor signalling pathway 79 1.00E-04 0.01054 ACLF vs. NC from 201 to 300 GO:0008334 histone mRNA metabolic process 26 0 0.01576 CHB vs. NC from 1 to 100 GO:0010310 regulation of hydrogen peroxide metabolic process 10 5.00E-04 0.019 ACLF vs. NC from 101 to 200 0 0.0126 ACLF vs. NC from 101 to 200 GO:0010499 proteasomal ubiquitin-independent protein catabolic process 23 0 0.0102 CHB vs. NC from 251 to 350 negative regulation of phosphatidylinositol biosynthetic GO:0010512 2 3.00E-04 0.0202 ACHD vs. NC from 1 to 100 process GO:0010710 regulation of collagen catabolic process 4 4.00E-04 0.0153 ACLF vs. NC from 151 to 250 GO:0010727 negative regulation of hydrogen peroxide metabolic process 5 7.00E-04 0.02828 ACLF vs. NC from 51 to 150 GO:0010743 regulation of macrophage derived foam cell differentiation 28 0 0.01154 ACLF vs. NC from 51 to 150 negative regulation of macrophage derived foam cell GO:0010745 13 0 0.01255 ACLF vs. NC from 151 to 250 differentiation

GO:0010827 regulation of glucose transmembrane transport 52 2.00E-04 0.01126 ACHD vs. NC from 201 to 300 GO:0010867 positive regulation of triglyceride biosynthetic process 10 0 0.0101 ACHD vs. NC from 51 to 150 GO:0010869 regulation of receptor biosynthetic process 19 5.00E-04 0.01127 ACLF vs. NC from 151 to 250 0 0.0238 ACLF vs. NC from 151 to 250 8.00E-04 0.01736 ACLF vs. NC from 201 to 300 GO:0010871 negative regulation of receptor biosynthetic process 6 8.00E-04 0.01683 ACHD vs. NC from 51 to 150 0 0.01851 ACHD vs. NC from 101 to 200 2.00E-04 0.01154 ACLF vs. NC from 1 to 100 GO:0010875 positive regulation of cholesterol efflux 14 1.00E-04 0.01154 ACLF vs. NC from 51 to 150 0 0.0101 ACHD vs. NC from 51 to 150 0 0.02453 ACHD vs. NC from 51 to 150 GO:0010887 negative regulation of cholesterol storage 7 0 0.02164 ACHD vs. NC from 101 to 200 7.00E-04 0.01587 CHB vs. NC from 51 to 150 0 0.0108 ACLF vs. NC from 151 to 250 GO:0010888 negative regulation of lipid storage 17 0 0.01247 ACHD vs. NC from 51 to 150 0 0.01188 ACHD vs. NC from 101 to 200 1.00E-04 0.01616 ACHD vs. NC from 101 to 200 GO:0010891 negative regulation of sequestering of triglyceride 5 1.00E-04 0.02222 ACLF vs. NC from 1 to 100 0 0.0204 ACLF vs. NC from 151 to 250 GO:0019322 pentose biosynthetic process 3 0 0.01736 ACHD vs. NC from 251 to 350 GO:0030574 collagen catabolic process 28 0 0.01046 ACLF vs. NC from 51 to 150 GO:0031145 anaphase-promoting complex-dependent catabolic process 35 0 0.01632 LC vs. NC from 1 to 100 0 0.01539 ACLF vs. NC from 51 to 150 GO:0032369 negative regulation of lipid transport 21 3.00E-04 0.01142 ACLF vs. NC from 101 to 200 0 0.01202 ACHD vs. NC from 51 to 150 GO:0032802 low-density lipoprotein particle receptor catabolic process 10 7.00E-04 0.01515 ACLF vs. NC from 51 to 150 GO:0033619 membrane protein proteolysis 33 0 0.01285 ACLF vs. NC from 51 to 150 GO:0038183 bile acid signalling pathway 3 2.00E-04 0.0202 ACHD vs. NC from 101 to 200 metabolism 0 0.01 ACLF vs. NC from 351 to 450 0 0.01 ACLF vs. NC from 401 to 500 GO:0042351 'de novo' GDP-L-fucose biosynthetic process 2 1.00E-04 0.0102 ACHD vs. NC from 251 to 350 1.00E-04 0.01041 ACHD vs. NC from 251 to 350

1.00E-04 0.01683 ACLF vs. NC from 1 to 100 GO:0045079 negative regulation of chemokine biosynthetic process 3 1.00E-04 0.0202 ACLF vs. NC from 51 to 150 low-density lipoprotein particle receptor biosynthetic GO:0045713 process 1 0.001 0.0505 ACHD vs. NC from 101 to 200 negative regulation of low-density lipoprotein particle 0 0.02721 ACLF vs. NC from 151 to 250 GO:0045715 3 receptor biosynthetic process 5.00E-04 0.0204 ACHD vs. NC from 251 to 350 GO:0045717 negative regulation of fatty acid biosynthetic process 10 2.00E-04 0.01134 LC vs. NC from 201 to 300 GO:0045922 negative regulation of fatty acid metabolic process 16 5.00E-04 0.0103 LC vs. NC from 201 to 300 GO:0046324 regulation of glucose import 39 0 0.01295 ACHD vs. NC from 201 to 300 GO:0046326 positive regulation of glucose import 27 3.00E-04 0.01122 CHB vs. NC from 401 to 500 GO:0046627 negative regulation of insulin receptor signalling pathway 25 5.00E-04 0.01896 LC vs. NC from 401 to 500 GO:0048009 insulin-like growth factor receptor signalling pathway 10 7.00E-04 0.0202 CHB vs. NC from 401 to 500 GO:0050748 negative regulation of lipoprotein metabolic process 4 0 0.0204 ACLF vs. NC from 151 to 250 GO:0051006 positive regulation of lipoprotein lipase activity 5 8.00E-04 0.01212 ACHD vs. NC from 101 to 200 GO:0060694 regulation of cholesterol transporter activity 2 0.001 0.02525 ACHD vs. NC from 101 to 200 0 0.01515 ACHD vs. NC from 51 to 150 GO:0061365 positive regulation of triglyceride lipase activity 6 6.00E-04 0.0101 ACHD vs. NC from 101 to 200 7.00E-04 0.01414 ACLF vs. NC from 51 to 150 GO:0070873 regulation of glycogen metabolic process 25 6.00E-04 0.01212 ACHD vs. NC from 1 to 100 8.00E-04 0.0101 CHB vs. NC from 401 to 500 GO:0071072 negative regulation of phospholipid biosynthetic process 3 5.00E-04 0.01346 ACHD vs. NC from 1 to 100 GO:0090218 positive regulation of lipid kinase activity 28 8.00E-04 0.01479 ACHD vs. NC from 201 to 300 0 0.05387 ACLF vs. NC from 1 to 100 GO:1900127 positive regulation of hyaluronan biosynthetic process 3 0 0.04713 ACLF vs. NC from 51 to 150 GO:1900221 regulation of amyloid-beta clearance 10 2.00E-04 0.01515 ACLF vs. NC from 51 to 150 regulation of carbohydrate metabolic process by regulation GO:1900402 5 1.00E-04 0.01818 ACHD vs. NC from 51 to 150 of transcription from RNA polymerase II promoter GO:1902661 positive regulation of glucose mediated signalling pathway 3 3.00E-04 0.03666 CHB vs. NC from 1 to 100 GO:1902991 regulation of amyloid precursor protein catabolic process 22 9.00E-04 0.01331 ACLF vs. NC from 1 to 100 GO:1903725 regulation of phospholipid metabolic process 56 1.00E-04 0.01082 ACHD vs. NC from 201 to 300 positive regulation of protein catabolic process in the 0 0.02424 ACLF vs. NC from 1 to 100 GO:1904352 5 vacuole 3.00E-04 0.02222 ACLF vs. NC from 51 to 150

1.00E-04 0.02222 ACLF vs. NC from 1 to 100 GO:1905165 regulation of lysosomal protein catabolic process 5 4.00E-04 0.0202 ACLF vs. NC from 51 to 150 1.00E-04 0.03703 ACLF vs. NC from 1 to 100 GO:1905167 positive regulation of lysosomal protein catabolic process 3 3.00E-04 0.03367 ACLF vs. NC from 51 to 150 GO:2000304 positive regulation of ceramide biosynthetic process 7 3.00E-04 0.0202 CHB vs. NC from 401 to 500 GO:2000467 positive regulation of glycogen (starch) synthase activity 4 1.00E-04 0.0153 ACHD vs. NC from 251 to 350 GO:2000573 positive regulation of DNA biosynthetic process 57 2.00E-04 0.01027 CHB vs. NC from 51 to 150 GO:2000628 regulation of miRNA metabolic process 8 3.00E-04 0.02525 ACLF vs. NC from 51 to 150 0.001 0.03434 ACLF vs. NC from 1 to 100 GO:2000630 positive regulation of miRNA metabolic process 5 1.00E-04 0.0404 ACLF vs. NC from 51 to 150 GO:2000646 positive regulation of receptor catabolic process 5 2.00E-04 0.01414 ACHD vs. NC from 101 to 200 GO:2001273 regulation of glucose import in response to insulin stimulus 13 0 0.01787 ACHD vs. NC from 201 to 300 GO:0055089 fatty acid homeostasis 10 5.00E-04 0.01443 LC vs. NC from 251 to 350 GO:0031998 regulation of fatty acid beta-oxidation 12 5.00E-04 0.01262 CHB vs. NC from 401 to 500 positive regulation of metanephric mesenchymal cell GO:0035793 migration by platelet-derived growth factor 3 1.00E-04 0.02693 ACHD vs. NC from 1 to 100 receptor-beta signalling pathway cellular response to corticotropin-releasing GO:0071376 4 0 0.02272 ACHD vs. NC from 51 to 150 hormone stimulus GO:0072124 regulation of glomerular mesangial cell proliferation 5 1.00E-04 0.01414 ACHD vs. NC from 1 to 100 metanephric-related 4.00E-04 0.01333 ACLF vs. NC from 101 to 200 GO:0072218 metanephric ascending thin limb development 3 1.00E-04 0.0136 ACLF vs. NC from 151 to 250 GO:0072237 metanephric proximal tubule development 1 0.001 0.03 ACLF vs. NC from 101 to 200 GO:0072287 metanephric distal tubule morphogenesis 1 8.00E-04 0.03 ACLF vs. NC from 101 to 200 positive regulation of metanephric mesenchymal cell GO:2000591 3 1.00E-04 0.02693 ACHD vs. NC from 1 to 100 migration 0 0.0122 ACLF vs. NC from 51 to 150 GO:0001776 leucocyte homeostasis 24 0 0.01136 ACHD vs. NC from 201 to 300 0 0.01232 ACHD vs. NC from 251 to 350 1.00E-04 0.02525 ACLF vs. NC from 1 to 100 GO:0002438 acute inflammatory response to antigenic stimulus 2 0 0.0303 ACLF vs. NC from 51 to 150 GO:0002523 leucocyte migration involved in inflammatory response 7 6.00E-04 0.0101 ACLF vs. NC from 51 to 150 GO:0002676 regulation of chronic inflammatory response 1 8.00E-04 0.0303 ACHD vs. NC from 1 to 100

1.00E-04 0.0101 ACLF vs. NC from 51 to 150 GO:0007159 leucocyte cell-cell adhesion 39 0 0.01307 ACLF vs. NC from 101 to 200 0 0.01046 ACLF vs. NC from 151 to 250 GO:0030866 cortical actin cytoskeleton organization 26 0 0.01204 ACHD vs. NC from 201 to 300 GO:0032707 negative regulation of interleukin-23 production 2 4.00E-04 0.03645 ACHD vs. NC from 251 to 350 GO:0035722 interleukin-12-mediated signalling pathway 42 1.00E-04 0.01095 ACLF vs. NC from 101 to 200 1.00E-04 0.01928 ACHD vs. NC from 1 to 100 GO:0038110 interleukin-2-mediated signalling pathway 11 0 0.0202 ACHD vs. NC from 51 to 150 0 0.01907 ACHD vs. NC from 1 to 100 GO:0038113 interleukin-9-mediated signalling pathway 9 0 0.0202 ACHD vs. NC from 51 to 150 4.00E-04 0.01875 ACHD vs. NC from 1 to 100 0 0.0202 ACHD vs. NC from 51 to 150 GO:0038114 interleukin-21-mediated signalling pathway 7 7.00E-04 0.02769 ACHD vs. NC from 251 to 350 0.001 0.02164 ACHD vs. NC from 251 to 350 4.00E-04 0.0101 ACLF vs. NC from 1 to 100 GO:0045416 positive regulation of interleukin-8 biosynthetic process 9 0 0.01122 ACLF vs. NC from 51 to 150 5.00E-04 0.01066 ACLF vs. NC from 101 to 200 GO:0050901 leucocyte tethering or rolling 15 0 0.01088 ACLF vs. NC from 151 to 250 8.00E-04 0.02092 ACHD vs. NC from 201 to 300 GO:0070102 interleukin-6-mediated signalling pathway 14 1.00E-04 0.02092 ACHD vs. NC from 251 to 350 inflammation GO:0070486 leucocyte aggregation 9 0 0.01666 ACLF vs. NC from 101 to 200 8.00E-04 0.01641 ACLF vs. NC from 51 to 150 1.00E-04 0.0153 ACLF vs. NC from 251 to 350 0 0.01641 ACHD vs. NC from 1 to 100 0 0.01503 CHB vs. NC from 101 to 200 0 0.01679 CHB vs. NC from 151 to 250 GO:0070498 interleukin-1-mediated signalling pathway 48 0.001 0.01073 CHB vs. NC from 201 to 300 0 0.01452 CHB vs. NC from 301 to 400 0 0.01041 CHB vs. NC from 351 to 450 4.00E-04 0.01202 LC vs. NC from 201 to 300 0 0.01503 LC vs. NC from 251 to 350 3.00E-04 0.01767 ACHD vs. NC from 1 to 100 GO:0070669 response to interleukin-2 12

GO:0070669 response to interleukin-2 12 0 0.01851 ACHD vs. NC from 51 to 150 7.00E-04 0.01936 ACHD vs. NC from 201 to 300 GO:0070671 response to interleukin-12 42 1.00E-04 0.01095 ACLF vs. NC from 101 to 200 GO:0070672 response to interleukin-15 13 9.00E-04 0.0259 ACHD vs. NC from 251 to 350 9.00E-04 0.01459 ACLF vs. NC from 51 to 150 3.00E-04 0.01234 ACHD vs. NC from 1 to 100 GO:0070741 response to interleukin-6 27 5.00E-04 0.01047 ACHD vs. NC from 51 to 150 4.00E-04 0.01346 ACHD vs. NC from 201 to 300 GO:0070757 interleukin-35-mediated signalling pathway 10 9.00E-04 0.02121 ACHD vs. NC from 251 to 350 1.00E-04 0.01717 ACHD vs. NC from 1 to 100 GO:0071104 response to interleukin-9 10 0 0.01818 ACHD vs. NC from 51 to 150 GO:0071353 cellular response to interleukin-4 7 5.00E-04 0.0101 ACHD vs. NC from 1 to 100 4.00E-04 0.01388 ACHD vs. NC from 1 to 100 GO:0071354 cellular response to interleukin-6 24 7.00E-04 0.01178 ACHD vs. NC from 51 to 150 5.00E-04 0.01515 ACHD vs. NC from 201 to 300 GO:2000483 negative regulation of interleukin-8 secretion 5 1.00E-04 0.0101 ACHD vs. NC from 201 to 300 6.00E-04 0.0103 LC vs. NC from 151 to 250 GO:0001768 establishment of T cell polarity 3 0.001 0.0103 LC vs. NC from 201 to 300 6.00E-04 0.01134 ACLF vs. NC from 1 to 100 GO:0002218 activation of innate immune response 163 0 0.01196 ACLF vs. NC from 51 to 150 0 0.01028 ACHD vs. NC from 1 to 100 0 0.01902 ACLF vs. NC from 1 to 100 innate immune response activating cell surface GO:0002220 60 1.00E-04 0.01835 ACLF vs. NC from 51 to 150 receptor signalling pathway 1.00E-04 0.01548 ACHD vs. NC from 1 to 100 GO:0002223 stimulatory C-type lectin receptor signalling pathway 57 1.00E-04 0.0163 ACHD vs. NC from 1 to 100 T cell activation via T cell receptor contact with antigen 8.00E-04 0.02 ACLF vs. NC from 101 to 200 GO:0002291 2 bound to MHC molecule on antigen presenting cell 0 0.02551 ACLF vs. NC from 151 to 250 GO:0002431 Fc receptor mediated stimulatory signalling pathway 127 0 0.01455 ACHD vs. NC from 201 to 300 GO:0002578 negative regulation of antigen processing and presentation 7 0.001 0.01311 ACHD vs. NC from 251 to 350 5.00E-04 0.01241 ACLF vs. NC from 1 to 100 0 0.01269 ACLF vs. NC from 51 to 150 GO:0002758 innate immune response-activating signal transduction 144 0 0.01073 ACHD vs. NC from 1 to 100

7.00E-04 0.0101 ACHD vs. NC from 201 to 300 positive regulation of natural killer cell mediated GO:0002860 cytotoxicity directed against tumor cell target 4 2.00E-04 0.01262 ACHD vs. NC from 251 to 350 0 0.01118 ACLF vs. NC from 1 to 100 GO:0010743 regulation of macrophage derived foam cell differentiation 28 0 0.0101 ACHD vs. NC from 51 to 150 positive regulation of macrophage derived foam cell 5.00E-04 0.01212 ACLF vs. NC from 1 to 100 GO:0010744 15 differentiation 7.00E-04 0.01212 ACLF vs. NC from 51 to 150 6.00E-04 0.01041 ACLF vs. NC from 201 to 300 negative regulation of macrophage derived foam cell GO:0010745 13 0 0.0132 ACHD vs. NC from 51 to 150 differentiation 0 0.01243 ACHD vs. NC from 101 to 200 GO:0010758 regulation of macrophage chemotaxis 13 0 0.01 ACLF vs. NC from 101 to 200 GO:0010759 positive regulation of macrophage chemotaxis 7 7.00E-04 0.01142 ACLF vs. NC from 101 to 200 GO:0031295 T cell costimulation 41 2.00E-04 0.02734 ACHD vs. NC from 201 to 300 GO:0038094 Fc-gamma receptor signalling pathway 126 1.00E-04 0.01467 ACHD vs. NC from 201 to 300 Fc-gamma receptor signalling pathway involved GO:0038096 125 1.00E-04 0.01478 ACHD vs. NC from 201 to 300 immune in phagocytosis GO:0043029 T cell homeostasis 10 7.00E-04 0.01717 ACLF vs. NC from 51 to 150 GO:0043304 regulation of mast cell degranulation 18 8.00E-04 0.01346 ACHD vs. NC from 201 to 300 3.00E-04 0.0102 ACHD vs. NC from 151 to 250 GO:0045356 positive regulation of interferon-alpha biosynthetic process 4 0 0.01262 ACHD vs. NC from 201 to 300 2.00E-04 0.0102 ACHD vs. NC from 151 to 250 GO:0045359 positive regulation of interferon-beta biosynthetic process 4 0 0.01262 ACHD vs. NC from 201 to 300 GO:0045629 negative regulation of T-helper 2 cell differentiation 2 6.00E-04 0.01515 ACHD vs. NC from 201 to 300 0 0.01329 ACHD vs. NC from 201 to 300 GO:0050852 T cell receptor signalling pathway 98 1.00E-04 0.01322 ACHD vs. NC from 251 to 350 positive regulation of antigen receptor-mediated GO:0050857 14 0 0.01659 ACHD vs. NC from 201 to 300 signalling pathway GO:0050862 positive regulation of T cell receptor signalling pathway 9 6.00E-04 0.01683 ACHD vs. NC from 201 to 300 1.00E-04 0.01152 ACHD vs. NC from 201 to 300 GO:0050870 positive regulation of T cell activation 149 3.00E-04 0.01171 ACHD vs. NC from 251 to 350 0 0.01537 ACHD vs. NC from 51 to 150 GO:0060330 regulation of response to interferon-gamma 23 1.00E-04 0.01273 ACHD vs. NC from 251 to 350 0 0.01537 ACHD vs. NC from 51 to 150 GO:0060334 23

GO:0060334 regulation of interferon-gamma-mediated signalling pathway 23 8.00E-04 0.01097 ACHD vs. NC from 101 to 200 0 0.01273 ACHD vs. NC from 251 to 350 negative regulation of interferon-gamma-mediated 0 0.01731 ACHD vs. NC from 51 to 150 GO:0060336 7 signalling pathway 0 0.01587 ACHD vs. NC from 101 to 200 0 0.012 ACLF vs. NC from 351 to 450 GO:0060754 positive regulation of mast cell chemotaxis 5 0 0.02222 ACHD vs. NC from 1 to 100 0 0.01414 ACHD vs. NC from 51 to 150 GO:0072539 T-helper 17 cell differentiation 8 0 0.01262 ACHD vs. NC from 51 to 150 GO:0097323 B cell adhesion 2 3.00E-04 0.015 ACLF vs. NC from 101 to 200 GO:2000401 regulation of lymphocyte migration 43 0 0.0101 ACLF vs. NC from 51 to 150 GO:2000406 positive regulation of T cell migration 22 0 0.01056 ACLF vs. NC from 51 to 150 GO:2000503 positive regulation of natural killer cell chemotaxis 5 2.00E-04 0.0101 ACHD vs. NC from 1 to 100 GO:2000547 regulation of dendritic cell dendrite assembly 3 4.00E-04 0.0103 LC vs. NC from 201 to 300 GO:0045348 positive regulation of MHC class II biosynthetic process 4 4.00E-04 0.01288 LC vs. NC from 251 to 350 GO:0007525 somatic muscle development 4 4.00E-04 0.01275 ACLF vs. NC from 151 to 250 GO:0031017 exocrine pancreas development 1 4.00E-04 0.03092 LC vs. NC from 251 to 350 0.001 0.0303 ACHD vs. NC from 1 to 100 GO:0031077 post-embryonic camera-type eye development 1 5.00E-04 0.0303 ACHD vs. NC from 51 to 150 GO:0035878 nail development 5 9.00E-04 0.01224 ACLF vs. NC from 151 to 250 0 0.01237 LC vs. NC from 251 to 350 GO:0042693 muscle cell fate commitment 10 3.00E-04 0.01237 LC vs. NC from 301 to 400 GO:0043045 DNA methylation involved in embryo development 4 0.001 0.01302 ACLF vs. NC from 201 to 300 GO:0048643 positive regulation of skeletal muscle tissue development 14 0 0.01104 LC vs. NC from 251 to 350 0 0.01767 LC vs. NC from 251 to 350 GO:0048742 regulation of skeletal muscle fiber development 7 5.00E-04 0.01472 LC vs. NC from 301 to 400 0 0.02061 LC vs. NC from 251 to 350 GO:0048743 positive regulation of skeletal muscle fiber development 6 2.00E-04 0.01718 LC vs. NC from 301 to 400 GO:0060674 placenta blood vessel development 7 4.00E-04 0.0102 ACLF vs. NC from 151 to 250 GO:0061314 Notch signalling involved in heart development 9 0 0.0202 ACLF vs. NC from 1 to 100 GO:0061515 myeloid cell development 15 0 0.01548 ACHD vs. NC from 201 to 300 9.00E-04 0.01 ACLF vs. NC from 101 to 200 GO:0072236 metanephric loop of Henle development 4 5.00E-04 0.0102 ACLF vs. NC from 151 to 250

GO:1905314 semi-lunar valve development 26 2.00E-04 0.01087 ACLF vs. NC from 1 to 100 GO:2000074 regulation of type B pancreatic cell development 8 3.00E-04 0.01932 LC vs. NC from 251 to 350 GO:0001738 morphogenesis of a polarized epithelium 21 6.00E-04 0.0101 ACHD vs. NC from 201 to 300 GO:0002089 lens morphogenesis in camera-type eye 7 2.00E-04 0.01311 ACHD vs. NC from 251 to 350 GO:0003180 aortic valve morphogenesis 16 2.00E-04 0.01199 ACLF vs. NC from 1 to 100 GO:0003184 pulmonary valve morphogenesis 15 0.001 0.01279 ACLF vs. NC from 1 to 100 GO:0061156 pulmonary artery morphogenesis 5 7.00E-04 0.01616 ACLF vs. NC from 1 to 100 development GO:0001829 trophectodermal cell differentiation 3 2.00E-04 0.02061 LC vs. NC from 301 to 400 GO:0010668 ectodermal cell differentiation 3 0 0.0204 ACLF vs. NC from 151 to 250 GO:0030316 osteoclast differentiation 24 8.00E-04 0.01094 ACHD vs. NC from 201 to 300 GO:0030859 polarized epithelial cell differentiation 12 9.00E-04 0.01515 ACHD vs. NC from 201 to 300 6.00E-04 0.0103 CHB vs. NC from 101 to 200 GO:0030860 regulation of polarized epithelial cell differentiation 2 1.00E-04 0.0102 CHB vs. NC from 151 to 250 GO:0035914 skeletal muscle cell differentiation 12 0 0.01202 LC vs. NC from 251 to 350 GO:0045601 regulation of endothelial cell differentiation 23 2.00E-04 0.01097 ACLF vs. NC from 51 to 150 GO:0045603 positive regulation of endothelial cell differentiation 9 0 0.0101 ACLF vs. NC from 51 to 150 GO:0045625 regulation of T-helper 1 cell differentiation 7 1.00E-04 0.01154 ACHD vs. NC from 201 to 300 GO:0045663 positive regulation of myoblast differentiation 15 1.00E-04 0.01237 LC vs. NC from 251 to 350 0 0.01243 ACLF vs. NC from 1 to 100 GO:0045685 regulation of glial cell differentiation 26 0 0.01165 ACLF vs. NC from 51 to 150 GO:0045687 positive regulation of glial cell differentiation 16 9.00E-04 0.0101 ACLF vs. NC from 51 to 150 0 0.01 ACLF vs. NC from 101 to 200 GO:0048333 mesodermal cell differentiation 13 0 0.01412 ACLF vs. NC from 151 to 250 0 0.01616 ACLF vs. NC from 1 to 100 GO:0048710 regulation of astrocyte differentiation 15 9.00E-04 0.01279 ACLF vs. NC from 51 to 150 0 0.02777 ACLF vs. NC from 1 to 100 GO:0048712 negative regulation of astrocyte differentiation 4 5.00E-04 0.0202 ACLF vs. NC from 51 to 150 GO:0060319 primitive erythrocyte differentiation 1 0.001 0.0303 ACHD vs. NC from 51 to 150 GO:0060487 lung epithelial cell differentiation 5 0.001 0.01414 ACHD vs. NC from 51 to 150 GO:1904948 midbrain dopaminergic neuron differentiation 11 0 0.01041 ACHD vs. NC from 301 to 400 Wnt signalling pathway involved in midbrain GO:1904953 9 0 0.01157 ACHD vs. NC from 301 to 400 dopaminergic neuron differentiation

GO:1905208 negative regulation of cardiocyte differentiation 11 9.00E-04 0.01545 ACLF vs. NC from 351 to 450 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 12 0 0.01116 LC vs. NC from 201 to 300 negative regulation of plasma membrane long-chain fatty GO:0010748 4 0 0.04797 ACLF vs. NC from 51 to 150 acid transport GO:0010828 positive regulation of glucose transmembrane transport 33 2.00E-04 0.01469 ACHD vs. NC from 201 to 300 protein transport to vacuole involved in ubiquitin-dependent 0 0.01562 LC vs. NC from 351 to 450 GO:0043328 protein catabolic process via the multivesicular body sorting 4 pathway 0 0.01804 LC vs. NC from 401 to 500 0 0.02 ACLF vs. NC from 101 to 200 2.00E-04 0.0136 ACLF vs. NC from 151 to 250 GO:0046968 peptide antigen transport 3 0 0.02 ACLF vs. NC from 101 to 200 2.00E-04 0.0136 ACLF vs. NC from 151 to 250 negative regulation of plasma membrane long-chain fatty GO:0010748 4 0 0.04797 ACLF vs. NC from 51 to 150 acid transport GO:0010828 positive regulation of glucose transmembrane transport 33 2.00E-04 0.01469 ACHD vs. NC from 201 to 300 GO:0090279 regulation of calcium ion import 25 5.00E-04 0.0101 ACLF vs. NC from 51 to 150 GO:0090280 positive regulation of calcium ion import 9 0 0.01122 ACHD vs. NC from 1 to 100 negative regulation of calcium ion import into sarcoplasmic GO:1902081 2 0.001 0.0101 CHB vs. NC from 401 to 500 reticulum GO:0072383 plus-end-directed vesicle transport along microtubule 5 0.001 0.01428 ACHD vs. NC from 151 to 250 regulation of calcium ion transmembrane transport via high GO:1902514 9 0 0.01122 ACLF vs. NC from 1 to 100 voltage-gated calcium channel 0 0.01857 ACLF vs. NC from 101 to 200 positive regulation of early endosome to late endosome GO:2000643 7 transport 0.001 0.0119 ACHD vs. NC from 301 to 400 6.00E-04 0.01166 ACHD vs. NC from 351 to 450 GO:0045175 basal protein localization 1 9.00E-04 0.04081 ACHD vs. NC from 251 to 350 localization GO:0045176 apical protein localization 5 8.00E-04 0.0102 ACHD vs. NC from 251 to 350 regulation of calcium ion transmembrane transport via high GO:1902514 9 0 0.01122 ACLF vs. NC from 1 to 100 voltage-gated calcium channel GO:0072383 plus-end-directed vesicle transport along microtubule 5 0.001 0.01428 ACHD vs. NC from 151 to 250 regulation of establishment of protein localization to 3.00E-04 0.01215 LC vs. NC from 351 to 450 GO:0070202 12 chromosome 0 0.017 CHB vs. NC from 151 to 250 GO:0090666 scaRNA localization to Cajal body 5 7.00E-04 0.02244 CHB vs. NC from 151 to 250

1.00E-04 0.02 ACLF vs. NC from 101 to 200 GO:1902966 positive regulation of protein localization to early endosome 6 4.00E-04 0.01562 ACHD vs. NC from 301 to 400 GO:1903076 regulation of protein localization to plasma membrane 75 0 0.01171 ACHD vs. NC from 201 to 300 positive regulation of protein localization to plasma GO:1903078 44 4.00E-04 0.01469 ACHD vs. NC from 201 to 300 membrane positive regulation of protein localization to chromosome, 0.001 0.01215 LC vs. NC from 351 to 450 GO:1904816 12 telomeric region 0 0.01785 CHB vs. NC from 151 to 250 positive regulation of establishment of protein localization 4.00E-04 0.01458 LC vs. NC from 351 to 450 GO:1904851 10 to telomere 0 0.0204 CHB vs. NC from 151 to 250 1.00E-04 0.0162 LC vs. NC from 351 to 450 GO:1904871 positive regulation of protein localization to Cajal body 9 0 0.02267 CHB vs. NC from 151 to 250 GO:1904872 regulation of telomerase RNA localization to Cajal body 17 1.00E-04 0.018 CHB vs. NC from 151 to 250 0 0.01857 ACLF vs. NC from 101 to 200 positive regulation of early endosome to late endosome GO:2000643 7 transport 0.001 0.0119 ACHD vs. NC from 301 to 400 6.00E-04 0.01166 ACHD vs. NC from 351 to 450 positive regulation of telomerase RNA localization to Cajal 5.00E-04 0.01855 CHB vs. NC from 101 to 200 GO:1904874 body 15 0 0.0204 CHB vs. NC from 151 to 250 GO:1905477 positive regulation of protein localization to membrane 94 6.00E-04 0.0116 ACHD vs. NC from 201 to 300 GO:0050927 positive regulation of positive chemotaxis 15 0 0.01144 ACHD vs. NC from 1 to 100 locomotion GO:0050930 induction of positive chemotaxis 10 0 0.01313 ACHD vs. NC from 1 to 100 GO:0060754 positive regulation of mast cell chemotaxis 5 4.00E-04 0.012 ACLF vs. NC from 401 to 500 membrane docking GO:0022614 membrane to membrane docking 5 2.00E-04 0.026 ACLF vs. NC from 101 to 200 GO:0006930 substrate-dependent cell migration, cell extension 7 0.001 0.0101 ACHD vs. NC from 201 to 300 GO:0010595 positive regulation of endothelial cell migration 85 4.00E-04 0.0102 ACHD vs. NC from 251 to 350 GO:0014839 myoblast migration involved in skeletal muscle regeneration 1 5.00E-04 0.0303 ACHD vs. NC from 201 to 300 chemorepulsion involved in embryonic olfactory bulb GO:0021834 3 1.00E-04 0.02356 ACLF vs. NC from 1 to 100 movement interneuron precursor migration GO:0043535 regulation of blood vessel endothelial cell migration 74 7.00E-04 0.01006 ACHD vs. NC from 251 to 350 positive regulation of blood vessel endothelial cell GO:0043536 45 6.00E-04 0.01292 ACHD vs. NC from 251 to 350 migration GO:0043615 astrocyte cell migration 2 7.00E-04 0.01515 ACHD vs. NC from 1 to 100 GO:0008057 eye pigment granule organization 1 1.00E-04 0.04081 ACHD vs. NC from 251 to 350

GO:0030865 cortical cytoskeleton organization 30 1.00E-04 0.01111 ACHD vs. NC from 201 to 300 GO:0030953 astral microtubule organization 6 6.00E-04 0.0189 LC vs. NC from 201 to 300 GO:0044803 multi-organism membrane organization 7 5.00E-04 0.01298 ACHD vs. NC from 1 to 100 organization GO:0097106 postsynaptic density organization 7 6.00E-04 0.01 ACLF vs. NC from 351 to 450 0 0.01262 ACHD vs. NC from 201 to 300 GO:0097581 lamellipodium organization 28 3.00E-04 0.01129 ACHD vs. NC from 251 to 350 4.00E-04 0.01414 ACLF vs. NC from 51 to 150 GO:1903392 negative regulation of adherens junction organization 15 4.00E-04 0.012 ACLF vs. NC from 101 to 200 2.00E-04 0.01028 ACLF vs. NC from 1 to 100 GO:0071375 cellular response to peptide hormone stimulus 169 1.00E-04 0.01045 ACLF vs. NC from 51 to 150 cellular response to low-density lipoprotein particle 3.00E-04 0.0119 ACLF vs. NC from 151 to 250 GO:0071404 12 stimulus 6.00E-04 0.01445 ACHD vs. NC from 251 to 350 0 0.01459 ACHD vs. NC from 101 to 200 GO:0097067 cellular response to thyroid hormone stimulus 9 0 0.01473 ACHD vs. NC from 151 to 250 response to cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 7 0.001 0.01731 ACHD vs. NC from 201 to 300 stimulus 0 0.01571 ACHD vs. NC from 201 to 300 GO:1900076 regulation of cellular response to insulin stimulus 45 5.00E-04 0.01212 ACHD vs. NC from 401 to 500 positive regulation of transcription from RNA polymerase II GO:1901522 20 9.00E-04 0.01414 ACLF vs. NC from 1 to 100 promoter involved in cellular response to chemical stimulus negative regulation of cellular response to testosterone GO:2000655 1 7.00E-04 0.04123 LC vs. NC from 251 to 350 stimulus GO:0009411 response to UV 117 0 0.01022 CHB vs. NC from 101 to 200 GO:0010332 response to gamma radiation 26 8.00E-04 0.01348 CHB vs. NC from 101 to 200 DNA damage response, signal transduction by p53 class GO:0030330 68 0 0.01197 LC vs. NC from 401 to 500 mediator GO:0032570 response to progesterone 12 4.00E-04 0.015 ACLF vs. NC from 101 to 200 GO:0033555 multicellular organismal response to stress 14 9.00E-04 0.01226 ACLF vs. NC from 1 to 100 GO:0034644 cellular response to UV 68 0 0.01152 CHB vs. NC from 101 to 200 1.00E-04 0.0202 ACHD vs. NC from 101 to 200 GO:0034699 response to luteinizing hormone 2 0 0.0204 ACHD vs. NC from 151 to 250 GO:0042770 signal transduction in response to DNA damage 91 3.00E-04 0.01246 LC vs. NC from 401 to 500

regulation of DNA-templated transcription in response to GO:0043620 74 2.00E-04 0.01023 ACHD vs. NC from 1 to 100 stress GO:0044321 response to leptin 12 3.00E-04 0.01094 ACHD vs. NC from 51 to 150 5.00E-04 0.02693 ACLF vs. NC from 51 to 150 GO:0048266 behavioral response to pain 3 1.00E-04 0.02333 ACLF vs. NC from 101 to 200 GO:0051775 response to redox state 10 0 0.0103 LC vs. NC from 251 to 350 GO:0051788 response to misfolded protein 20 8.00E-04 0.0101 ACLF vs. NC from 1 to 100 0 0.01652 ACHD vs. NC from 1 to 100 response to GO:0060416 response to growth hormone 22 0 0.01698 ACHD vs. NC from 51 to 150 substance regulation of transcription from RNA polymerase II GO:0061394 2 5.00E-04 0.02 CHB vs. NC from 1 to 100 promoter in response to arsenic-containing substance regulation of transcription from RNA polymerase II GO:0061418 31 7.00E-04 0.01238 ACHD vs. NC from 1 to 100 promoter in response to hypoxia 1.00E-04 0.04292 ACLF vs. NC from 1 to 100 GO:0071316 cellular response to nicotine 4 0 0.04797 ACLF vs. NC from 51 to 150 GO:0071455 cellular response to hyperoxia 4 0 0.02295 ACHD vs. NC from 251 to 350 GO:0072739 response to anisomycin 2 0.001 0.03 CHB vs. NC from 1 to 100 0 0.01193 ACHD vs. NC from 101 to 200 GO:0097066 response to thyroid hormone 11 0 0.01205 ACHD vs. NC from 151 to 250 0 0.01571 CHB vs. NC from 51 to 150 GO:1900034 regulation of cellular response to heat 45 1.00E-04 0.01672 CHB vs. NC from 101 to 200 GO:1904385 cellular response to angiotensin 11 1.00E-04 0.03122 ACLF vs. NC from 51 to 150 GO:1904645 response to amyloid-beta 28 1.00E-04 0.01406 ACHD vs. NC from 201 to 300 positive regulation of transcription from RNA polymerase II GO:1990440 11 5.00E-04 0.01325 LC vs. NC from 351 to 450 promoter in response to endoplasmic reticulum stress 8.00E-04 0.03108 ACLF vs. NC from 1 to 100 GO:1990776 response to angiotensin 13 1.00E-04 0.03185 ACLF vs. NC from 51 to 150 GO:0043397 regulation of corticotropin-releasing hormone secretion 1 1.00E-04 0.04123 LC vs. NC from 251 to 350 positive regulation of corticotropin-releasing hormone GO:0051466 secretion 1 1.00E-04 0.04123 LC vs. NC from 251 to 350 GO:0070459 prolactin secretion 2 9.00E-04 0.01515 ACHD vs. NC from 201 to 300 secretion positive regulation of fever generation by positive regulation GO:0071812 2 8.00E-04 0.02061 LC vs. NC from 251 to 350 of prostaglandin secretion

GO:0090188 negative regulation of pancreatic juice secretion 1 0.001 0.0404 ACHD vs. NC from 51 to 150 GO:0090341 negative regulation of secretion of lysosomal enzymes 1 9.00E-04 0.0404 ACHD vs. NC from 51 to 150 protein insertion into mitochondrial membrane involved in GO:0001844 6 2.00E-04 0.0101 CHB vs. NC from 51 to 150 apoptotic signalling pathway 0 0.01709 ACHD vs. NC from 1 to 100 GO:0002755 MyD88-dependent toll-like receptor signalling pathway 26 4.00E-04 0.01282 CHB vs. NC from 301 to 400 0.001 0.01625 LC vs. NC from 251 to 350 8.00E-04 0.01586 CHB vs. NC from 101 to 200 GO:0002756 MyD88-independent toll-like receptor signalling pathway 26 9.00E-04 0.0153 CHB vs. NC from 151 to 250 1.00E-04 0.01398 CHB vs. NC from 301 to 400 GO:0007167 enzyme linked receptor protein signalling pathway 554 0 0.01018 ACHD vs. NC from 251 to 350 transmembrane receptor protein tyrosine kinase 0 0.01195 ACHD vs. NC from 201 to 300 GO:0007169 398 signalling pathway 0 0.01207 ACHD vs. NC from 251 to 350 GO:0007173 epidermal growth factor receptor signalling pathway 46 0 0.02042 ACHD vs. NC from 201 to 300 0 0.01423 ACHD vs. NC from 1 to 100 GO:0007212 dopamine receptor signalling pathway 22 2.00E-04 0.01056 ACHD vs. NC from 51 to 150 GO:1990256 signal clustering 1 1.00E-04 0.0204 LC vs. NC from 1 to 00 GO:0007219 Notch signalling pathway 63 0 0.01138 ACLF vs. NC from 1 to 100 0 0.01283 ACLF vs. NC from 101 to 200 0 0.01207 ACLF vs. NC from 151 to 250 GO:0007229 integrin-mediated signalling pathway 60 0 0.0138 ACHD vs. NC from 201 to 300 2.00E-04 0.0136 ACHD vs. NC from 251 to 350 3.00E-04 0.01443 ACLF vs. NC from 51 to 150 1.00E-04 0.0119 ACLF vs. NC from 201 to 300 0 0.01475 ACLF vs. NC from 251 to 350 0 0.01479 ACHD vs. NC from 1 to 100 1.00E-04 0.01082 ACHD vs. NC from 51 to 150 GO:0007249 I-kappaB kinase/NF-kappaB signalling 56 0 0.0102 ACHD vs. NC from 151 to 250 0 0.01352 ACHD vs. NC from 201 to 300 1.00E-04 0.01311 ACHD vs. NC from 251 to 350 1.00E-04 0.01239 CHB vs. NC from 151 to 250 0 0.01352 CHB vs. NC from 301 to 400

GO:0008593 regulation of Notch signalling pathway 72 0 0.0122 ACLF vs. NC from 1 to 100 GO:0035333 Notch receptor processing, ligand-dependent 7 4.00E-04 0.01 ACLF vs. NC from 101 to 200 GO:0010737 protein kinase A signalling 10 2.00E-04 0.011 ACLF vs. NC from 101 to 200 5.00E-04 0.01029 ACHD vs. NC from 1 to 100 positive regulation of phosphatidylinositol 3-kinase GO:0014068 52 signalling 6.00E-04 0.01223 ACHD vs. NC from 201 to 300 3.00E-04 0.01098 LC vs. NC from 1 to 00 negative regulation of transforming growth factor GO:0030512 52 0 0.01059 ACLF vs. NC from 251 to 350 beta receptor signalling pathway GO:0030522 intracellular receptor signalling pathway 117 9.00E-04 0.0113 ACLF vs. NC from 1 to 100 0 0.01143 ACLF vs. NC from 251 to 350 0 0.01094 ACLF vs. NC from 301 to 400 GO:0031098 stress-activated protein kinase signalling cascade 116 2.00E-04 0.01075 LC vs. NC from 251 to 350 0 0.01306 LC vs. NC from 401 to 500 0 0.01055 CHB vs. NC from 151 to 250 negative regulation of intracellular estrogen GO:0033147 10 0 0.01052 LC vs. NC from 101 to 200 receptor signalling pathway 1.00E-04 0.01836 ACLF vs. NC from 251 to 350 GO:0034134 toll-like receptor 2 signalling pathway 5 3.00E-04 0.01428 ACHD vs. NC from 351 to 450 0 0.01414 CHB vs. NC from 301 to 400 GO:0034136 negative regulation of toll-like receptor 2 signalling pathway 5 0.001 0.0202 ACHD vs. NC from 201 to 300 GO:0034141 positive regulation of toll-like receptor 3 signalling pathway 4 1.00E-04 0.0153 ACHD vs. NC from 351 to 450 GO:0035357 peroxisome proliferator activated receptor signalling pathway 6 7.00E-04 0.01515 ACHD vs. NC from 101 to 200 9.00E-04 0.01589 CHB vs. NC from 101 to 200 GO:0035666 TRIF-dependent toll-like receptor signalling pathway 24 5.00E-04 0.01573 CHB vs. NC from 151 to 250 0 0.01515 CHB vs. NC from 301 to 400

nucleotide-binding domain, leucine rich repeat containing 2.00E-04 0.01864 ACHD vs. NC from 1 to 100 GO:0035872 26 receptor signalling pathway 0 0.01903 CHB vs. NC from 301 to 400 GO:0038001 paracrine signalling 5 3.00E-04 0.0101 ACHD vs. NC from 1 to 100 0 0.0303 ACLF vs. NC from 1 to 100 GO:0038026 reelin-mediated signalling pathway 3 2.00E-04 0.02693 ACLF vs. NC from 51 to 150 1.00E-04 0.02333 ACLF vs. NC from 101 to 200

GO:0038027 apolipoprotein A-I-mediated signalling pathway 4 2.00E-04 0.0204 ACLF vs. NC from 151 to 250 GO:0038030 non-canonical Wnt signalling pathway via MAPK cascade 5 4.00E-04 0.01458 ACLF vs. NC from 201 to 300 GO:0038031 non-canonical Wnt signalling pathway via JNK cascade 4 0 0.01822 ACLF vs. NC from 201 to 300 3.00E-04 0.01329 ACLF vs. NC from 201 to 300 0 0.01864 ACLF vs. NC from 251 to 350 0 0.01811 ACHD vs. NC from 1 to 100 GO:0038061 NIK/NF-kappaB signalling 29 0 0.01358 ACHD vs. NC from 51 to 150 2.00E-04 0.01477 CHB vs. NC from 151 to 250 0 0.01393 CHB vs. NC from 301 to 400 0 0.01172 CHB vs. NC from 351 to 450 GO:0038084 vascular endothelial growth factor signalling pathway 16 2.00E-04 0.01136 ACHD vs. NC from 1 to 100 positive regulation of cell proliferation by VEGF-activated GO:0038091 3 0 0.0303 ACHD vs. NC from 1 to 100 platelet derived growth factor receptor signalling pathway GO:0038093 Fc receptor signalling pathway 172 0 0.01474 ACHD vs. NC from 201 to 300 0 0.01943 ACHD vs. NC from 201 to 300 GO:0038127 ERBB signalling pathway 66 6.00E-04 0.01886 ACHD vs. NC from 251 to 350 GO:0038128 ERBB2 signalling pathway 31 0 0.0228 ACHD vs. NC from 201 to 300 GO:0038129 ERBB3 signalling pathway 2 0 0.02604 ACLF vs. NC from 201 to 300 GO:0038133 ERBB2-ERBB3 signalling pathway 1 0 0.05208 ACLF vs. NC from 201 to 300 GO:0098976 excitatory chemical synaptic transmission 7 1.00E-04 0.01571 ACLF vs. NC from 401 to 500 regulation of postsynaptic neurotransmitter receptor GO:0099149 2 5.00E-04 0.02525 ACHD vs. NC from 201 to 300 internalization regulation of epidermal growth factor receptor 0 0.0127 ACHD vs. NC from 201 to 300 GO:0042058 66 signalling pathway 0 0.01345 ACHD vs. NC from 251 to 350 negative regulation of epidermal growth factor GO:0042059 34 0.001 0.01336 ACHD vs. NC from 201 to 300 receptor signalling pathway signalling positive regulation of epidermal growth factor GO:0045742 23 0 0.01242 ACHD vs. NC from 251 to 350 receptor signalling pathway GO:0045746 negative regulation of Notch signalling pathway 27 0 0.01309 ACLF vs. NC from 51 to 150 GO:0045747 positive regulation of Notch signalling pathway 37 0 0.01528 ACLF vs. NC from 1 to 100 GO:0046626 regulation of insulin receptor signalling pathway 34 0 0.01426 ACHD vs. NC from 201 to 300 GO:0046627 negative regulation of insulin receptor signalling pathway 25 2.00E-04 0.01898 ACHD vs. NC from 201 to 300

vascular endothelial growth factor receptor GO:0048010 60 2.00E-04 0.02138 ACHD vs. NC from 201 to 300 signalling pathway 5.00E-04 0.01952 ACHD vs. NC from 201 to 300 GO:0048011 neurotrophin TRK receptor signalling pathway 15 5.00E-04 0.02244 ACHD vs. NC from 251 to 350 0 0.02174 ACHD vs. NC from 201 to 300 GO:0048013 ephrin receptor signalling pathway 72 3.00E-04 0.02083 ACHD vs. NC from 251 to 350 GO:0048384 retinoic acid receptor signalling pathway 6 0 0.02356 ACLF vs. NC from 1 to 100 GO:0051896 regulation of protein kinase B signalling 168 2.00E-04 0.01004 ACHD vs. NC from 201 to 300 GO:0051897 positive regulation of protein kinase B signalling 136 3.00E-04 0.01084 ACHD vs. NC from 201 to 300 1.00E-04 0.01068 ACLF vs. NC from 201 to 300 0 0.01282 ACLF vs. NC from 251 to 350 GO:0060071 Wnt signalling pathway, planar cell polarity pathway 39 0 0.01125 ACHD vs. NC from 251 to 350 0 0.01041 ACHD vs. NC from 301 to 400 8.00E-04 0.01594 ACHD vs. NC from 1 to 100 GO:0060396 growth hormone receptor signalling pathway 19 0 0.01648 ACHD vs. NC from 51 to 150 JAK-STAT cascade involved in growth hormone 5.00E-04 0.01787 ACHD vs. NC from 1 to 100 GO:0060397 13 signalling pathway 0 0.01942 ACHD vs. NC from 51 to 150 GO:0061314 Notch signalling involved in heart development 9 0 0.0202 ACLF vs. NC from 1 to 100 nucleotide-binding oligomerization domain containing 2.00E-04 0.01939 ACHD vs. NC from 1 to 100 GO:0070423 25 signalling pathway 0 0.01979 CHB vs. NC from 301 to 400

9.00E-04 0.0153 ACLF vs. NC from 251 to 350 regulation of nucleotide-binding oligomerization domain GO:0070424 6 containing signalling pathway 0 0.0187 ACHD vs. NC from 251 to 350 0 0.0202 CHB vs. NC from 301 to 400 5.00E-04 0.015 CHB vs. NC from 351 to 450 negative regulation of nucleotide-binding oligomerization GO:0070433 1 9.00E-04 0.04081 ACHD vs. NC from 251 to 350 domain containing 2 signalling pathway 9.00E-04 0.0202 ACHD vs. NC from 201 to 300 TNFSF11-mediated signalling pathway 2 GO:0071847 3.00E-04 0.02061 LC vs. NC from 251 to 350 positive regulation of ERK1 and ERK2 cascade via GO:0071848 2 8.00E-04 0.02061 LC vs. NC from 251 to 350 TNFSF11-mediated signalling

G-protein coupled receptor signalling pathway involved GO:0086103 6 0.001 0.02693 ACLF vs. NC from 51 to 150 in heart process positive regulation of phospholipase C-activating G-protein GO:1900738 coupled receptor signalling pathway 3 1.00E-04 0.02356 ACLF vs. NC from 1 to 100 positive regulation of protein insertion into mitochondrial GO:1900740 membrane involved in apoptotic signalling pathway 23 9.00E-04 0.0163 LC vs. NC from 351 to 450 positive regulation of mitochondrial outer membrane GO:1901030 permeabilization involved in apoptotic signalling pathway 30 0.001 0.01388 LC vs. NC from 351 to 450 3.00E-04 0.01346 ACHD vs. NC from 201 to 300 GO:1901185 negative regulation of ERBB signalling pathway 39 0.001 0.01334 ACHD vs. NC from 251 to 350 GO:1901186 positive regulation of ERBB signalling pathway 25 1.00E-04 0.01183 ACHD vs. NC from 251 to 350 semaphorin-plexin signalling pathway involved in GO:1902287 8 0 0.0102 LC vs. NC from 1 to 00 axon guidance GO:1902659 regulation of glucose mediated signalling pathway 4 4.00E-04 0.0275 CHB vs. NC from 1 to 100 Wnt signalling pathway involved in midbrain GO:1904953 9 0 0.01157 ACHD vs. NC from 301 to 400 dopaminergic neuron differentiation 6.00E-04 0.01004 ACLF vs. NC from 251 to 350 GO:0007254 JNK cascade 63 0 0.01015 ACLF vs. NC from 301 to 400 5.00E-04 0.0103 ACLF vs. NC from 101 to 200 0 0.01132 ACHD vs. NC from 1 to 100 GO:0007259 JAK-STAT cascade 33 0 0.0104 ACHD vs. NC from 51 to 150 6.00E-04 0.01132 ACHD vs. NC from 201 to 300 1.00E-04 0.01163 ACHD vs. NC from 401 to 500 GO:0051056 regulation of small GTPase mediated signal transduction 217 0 0.01126 ACHD vs. NC from 201 to 300 GO:0046426 negative regulation of JAK-STAT cascade 15 1.00E-04 0.0136 ACHD vs. NC from 251 to 350 0 0.01064 ACLF vs. NC from 51 to 150 GO:0007265 Ras protein signal transduction 204 0 0.01056 ACLF vs. NC from 201 to 300 0 0.01175 ACLF vs. NC from 251 to 350 0 0.01057 ACLF vs. NC from 51 to 150 0 0.01052 ACLF vs. NC from 251 to 350 GO:0007266 Rho protein signal transduction 64 0 0.01084 ACHD vs. NC from 151 to 250 0 0.01057 ACHD vs. NC from 201 to 300 0 0.01014 LC vs. NC from 251 to 350

3.00E-04 0.03092 LC vs. NC from 151 to 250 GO:0031291 Ran protein signal transduction 2 5.00E-04 0.03092 LC vs. NC from 201 to 300 GO:0016601 Rac protein signal transduction 16 1.00E-04 0.01275 ACLF vs. NC from 251 to 350 0 0.01225 ACLF vs. NC from 201 to 300 GO:0032482 Rab protein signal transduction 68 0 0.0135 ACLF vs. NC from 251 to 350 3.00E-04 0.01752 LC vs. NC from 201 to 300 GO:0032486 Rap protein signal transduction 10 1.00E-04 0.01855 LC vs. NC from 251 to 350 0 0.01281 ACLF vs. NC from 251 to 350 5.00E-04 0.01109 ACLF vs. NC from 301 to 400 6.00E-04 0.01071 ACHD vs. NC from 1 to 100 GO:0051403 stress-activated MAPK cascade 82 9.00E-04 0.01106 LC vs. NC from 251 to 350 2.00E-04 0.01244 LC vs. NC from 401 to 500 0 0.01207 CHB vs. NC from 151 to 250 0.001 0.01785 ACLF vs. NC from 201 to 300 GO:0150012 positive regulation of neuron projection arborization 7 5.00E-04 0.01875 ACHD vs. NC from 201 to 300 0 0.02769 ACHD vs. NC from 251 to 350 GO:0070374 positive regulation of ERK1 and ERK2 cascade 188 1.00E-04 0.01025 ACHD vs. NC from 251 to 350 GO:0007264 small GTPase mediated signal transduction 228 0 0.01105 ACLF vs. NC from 251 to 350 GO:0023016 signal transduction by trans-phosphorylation 3 1.00E-04 0.01666 ACLF vs. NC from 301 to 400 GO:1903753 negative regulation of p38MAPK cascade 4 9.00E-04 0.01767 CHB vs. NC from 301 to 400 transcription-dependent tethering of RNA polymerase II GO:0000972 6 4.00E-04 0.01346 CHB vs. NC from 301 to 400 gene DNA at nuclear periphery transcriptional start site selection at RNA polymerase II GO:0001174 1 3.00E-04 0.0421 LC vs. NC from 101 to 200 promoter 0 0.01084 ACLF vs. NC from 1 to 100 GO:0006367 transcription initiation from RNA polymerase II promoter 150 0 0.01144 ACHD vs. NC from 51 to 150 0 0.0101 CHB vs. NC from 51 to 150 GO:0006369 termination of RNA polymerase II transcription 34 0 0.01264 CHB vs. NC from 1 to 100 GO:0007221 positive regulation of transcription of Notch receptor target 17 0 0.02079 ACLF vs. NC from 1 to 100 0 0.01052 LC vs. NC from 101 to 200 GO:0033119 negative regulation of RNA splicing 18 0 0.01222 CHB vs. NC from 1 to 100 0 0.01122 CHB vs. NC from 51 to 150

0 0.01017 LC vs. NC from 101 to 200 GO:0045292 mRNA cis splicing, via spliceosome 30 0 0.01033 CHB vs. NC from 1 to 100 GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process 6 1.00E-04 0.01374 LC vs. NC from 151 to 250 3.00E-04 0.0103 LC vs. NC from 151 to 250 GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process 5 0.001 0.0103 LC vs. NC from 201 to 300 4.00E-04 0.0103 LC vs. NC from 151 to 250 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing 6 2.00E-04 0.01202 LC vs. NC from 201 to 300 nuclear-transcribed mRNA catabolic process, exonucleolytic, 0 0.01145 LC vs. NC from 151 to 250 GO:0034427 9 3'-5' 0 0.0126 LC vs. NC from 201 to 300 0 0.01159 LC vs. NC from 151 to 250 GO:0034475 U4 snRNA 3'-end processing 8 0 0.01288 LC vs. NC from 201 to 300 GO:0000389 mRNA 3'-splice site recognition 6 0 0.01683 CHB vs. NC from 301 to 400 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA GO:0000480 3 7.00E-04 0.01736 LC vs. NC from 351 to 450 transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0033683 nucleotide-excision repair, DNA incision 39 0 0.01165 CHB vs. NC from 51 to 150 GO:0098789 pre-mRNA cleavage required for polyadenylation 13 6.00E-04 0.01153 CHB vs. NC from 1 to 100 GO:0009299 mRNA transcription 21 2.00E-04 0.01 CHB vs. NC from 1 to 100 positive regulation of DNA-templated transcription, GO:0032786 25 4.00E-04 0.01212 CHB vs. NC from 51 to 150 elongation negative regulation of transcription elongation from RNA GO:0034244 5 4.00E-04 0.0103 LC vs. NC from 151 to 250 polymerase II promoter regulation of DNA-templated transcription in response to GO:0043620 74 2.00E-04 0.01023 ACHD vs. NC from 1 to 100 transcription stress regulation of RNA polymerase II transcriptional 4.00E-04 0.02203 CHB vs. NC from 51 to 150 GO:0045898 11 preinitiation complex assembly 0 0.01909 CHB vs. NC from 351 to 450 positive regulation of RNA polymerase II transcriptional 2.00E-04 0.0303 CHB vs. NC from 51 to 150 GO:0045899 7 preinitiation complex assembly 0 0.02571 CHB vs. NC from 351 to 450 GO:0045943 positive regulation of transcription by RNA polymerase I 22 0 0.01 CHB vs. NC from 1 to 100 positive regulation of NF-kappaB transcription factor GO:0051092 129 0 0.01012 ACLF vs. NC from 251 to 350 activity 9.00E-04 0.01145 LC vs. NC from 51 to 150 GO:0051123 RNA polymerase II transcriptional preinitiation complex 10 0 0.01789 LC vs. NC from 101 to 200 assembly

assembly 5.00E-04 0.01212 CHB vs. NC from 51 to 150 regulation of transcription initiation from RNA polymerase 2.00E-04 0.01394 CHB vs. NC from 51 to 150 GO:0060260 21 II promoter 0 0.01238 CHB vs. NC from 351 to 450 positive regulation of transcription initiation from RNA 4.00E-04 0.01803 CHB vs. NC from 51 to 150 GO:0060261 14 polymerase II promoter 5.00E-04 0.01428 CHB vs. NC from 351 to 450 1.00E-04 0.01346 ACHD vs. NC from 51 to 150 GO:0060850 regulation of transcription involved in cell fate commitment 9 0 0.01346 ACHD vs. NC from 101 to 200 3.00E-04 0.01111 CHB vs. NC from 1 to 100 regulation of transcription from RNA polymerase II GO:0061394 2 5.00E-04 0.02 CHB vs. NC from 1 to 100 promoter in response to arsenic-containing substance regulation of transcription from RNA polymerase II GO:0061418 31 7.00E-04 0.01238 ACHD vs. NC from 1 to 100 promoter in response to hypoxia positive regulation of transcription of nucleolar large rRNA GO:1901838 10 5.00E-04 0.016 CHB vs. NC from 1 to 100 by RNA polymerase I regulation of pri-miRNA transcription by RNA polymerase 0 0.01515 ACHD vs. NC from 1 to 100 GO:1902893 28 II 7.00E-04 0.01107 CHB vs. NC from 1 to 100 0 0.01376 LC vs. NC from 101 to 200 GO:0048025 negative regulation of mRNA splicing, via spliceosome 13 0 0.01538 CHB vs. NC from 1 to 100 1.00E-04 0.0132 CHB vs. NC from 51 to 150 negative regulation of pri-miRNA transcription by RNA 6.00E-04 0.01101 ACHD vs. NC from 51 to 150 GO:1902894 11 polymerase II 0 0.01101 CHB vs. NC from 201 to 300 positive regulation of pri-miRNA transcription by RNA GO:1902895 19 1.00E-04 0.0202 ACHD vs. NC from 1 to 100 polymerase II positive regulation of transcription from RNA polymerase II GO:1990440 11 5.00E-04 0.01325 LC vs. NC from 351 to 450 promoter in response to endoplasmic reticulum stress GO:0043967 histone H4 acetylation 39 0 0.01242 CHB vs. NC from 101 to 200 0 0.01571 CHB vs. NC from 1 to 100 GO:0043968 histone H2A acetylation 14 0 0.01803 CHB vs. NC from 51 to 150 2.00E-04 0.02282 CHB vs. NC from 101 to 200 GO:0043987 histone H3-S10 phosphorylation 3 2.00E-04 0.02807 LC vs. NC from 101 to 200 0 0.03157 LC vs. NC from 101 to 200 GO:0043988 histone H3-S28 phosphorylation 3 3.00E-04 0.02405 LC vs. NC from 151 to 250

GO:0000186 activation of MAPKK activity 27 3.00E-04 0.01234 ACHD vs. NC from 201 to 300 GO:0000187 activation of MAPK activity 114 1.00E-04 0.01067 LC vs. NC from 401 to 500 GO:0006427 histidyl-tRNA aminoacylation 2 8.00E-04 0.01546 CHB vs. NC from 101 to 200 GO:0006434 seryl-tRNA aminoacylation 2 7.00E-04 0.01515 CHB vs. NC from 51 to 150 GO:0010518 positive regulation of phospholipase activity 51 3.00E-04 0.01128 ACHD vs. NC from 1 to 100 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity 3 0 0.03367 ACLF vs. NC from 1 to 100 GO:0002778 antibacterial peptide production 3 1.00E-04 0.02356 ACLF vs. NC from 51 to 150 GO:0031623 receptor internalization 45 4.00E-04 0.01257 ACLF vs. NC from 51 to 150 GO:0033623 regulation of integrin activation 10 0.001 0.01122 ACHD vs. NC from 151 to 250 0 0.01081 ACLF vs. NC from 201 to 300 GO:0043113 receptor clustering 26 0 0.01295 ACHD vs. NC from 251 to 350 GO:0060558 regulation of calcidiol 1-monooxygenase activity 7 5.00E-04 0.01875 ACLF vs. NC from 1 to 100 GO:0060193 positive regulation of lipase activity 59 6.00E-04 0.01044 ACHD vs. NC from 1 to 100 GO:0090218 positive regulation of lipid kinase activity 28 0.001 0.01166 LC vs. NC from 1 to 00 GO:0097340 inhibition of cysteine-type endopeptidase activity 10 0 0.01111 CHB vs. NC from 301 to 400 0 0.01063 ACHD vs. NC from 201 to 300 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 169 0 0.01104 ACHD vs. NC from 251 to 350 0 0.01034 ACHD vs. NC from 201 to 300 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 124 0 0.01069 ACHD vs. NC from 251 to 350 positive regulation of DNA-templated transcription, GO:2000144 21 1.00E-04 0.01142 CHB vs. NC from 351 to 450 initiation regulation of cyclin-dependent protein serine/threonine 3.00E-04 0.01241 LC vs. NC from 401 to 500 GO:0000079 88 kinase activity 2.00E-04 0.01101 CHB vs. NC from 151 to 250 GO:0051354 negative regulation of oxidoreductase activity 18 0 0.01066 ACLF vs. NC from 1 to 100 GO:2000117 negative regulation of cysteine-type endopeptidase activity 64 7.00E-04 0.0101 ACLF vs. NC from 51 to 150 GO:2000310 regulation of NMDA receptor activity 12 4.00E-04 0.0187 ACHD vs. NC from 251 to 350 GO:0016572 histone phosphorylation 17 4.00E-04 0.02022 LC vs. NC from 51 to 150 GO:0016575 histone deacetylation 41 2.00E-04 0.01108 CHB vs. NC from 51 to 150 GO:0071441 negative regulation of histone H3-K14 acetylation 1 0.001 0.04123 LC vs. NC from 251 to 350 GO:1901675 negative regulation of histone H3-K27 acetylation 1 7.00E-04 0.07 CHB vs. NC from 1 to 100 2.00E-04 0.01414 ACLF vs. NC from 1 to 100 GO:0000338 protein deneddylation 10 0 0.013 CHB vs. NC from 351 to 450

2.00E-04 0.0101 CHB vs. NC from 401 to 500 GO:0006476 protein deacetylation 44 0 0.01078 CHB vs. NC from 51 to 150 GO:0006610 ribosomal protein import into nucleus 7 6.00E-04 0.01325 LC vs. NC from 201 to 300 GO:0007260 tyrosine phosphorylation of STAT protein 6 6.00E-04 0.0202 ACHD vs. NC from 201 to 300 GO:0010499 proteasomal ubiquitin-independent protein catabolic process 23 2.00E-04 0.0112 LC vs. NC from 401 to 500 positive regulation of pathway-restricted SMAD protein GO:0010862 45 0 0.01018 LC vs. NC from 51 to 150 phosphorylation GO:0016560 protein import into peroxisome matrix, docking 4 5.00E-04 0.0153 CHB vs. NC from 251 to 350 5.00E-04 0.01435 ACLF vs. NC from 1 to 100 GO:0031293 membrane protein intracellular domain proteolysis 19 0 0.01648 ACLF vs. NC from 51 to 150 GO:0032147 activation of protein kinase activity 232 0 0.01035 LC vs. NC from 401 to 500 GO:0032986 protein-DNA complex disassembly 21 0 0.01476 CHB vs. NC from 1 to 100 GO:0033235 positive regulation of protein sumoylation 9 8.00E-04 0.0136 ACLF vs. NC from 251 to 350 GO:0033619 membrane protein proteolysis 33 4.00E-04 0.01132 ACLF vs. NC from 1 to 100 5.00E-04 0.01767 ACLF vs. NC from 1 to 100 GO:0034380 high-density lipoprotein particle assembly 12 7.00E-04 0.01599 ACLF vs. NC from 51 to 150 protein transport to vacuole involved in ubiquitin-dependent 0 0.01562 LC vs. NC from 351 to 450 GO:0043328 protein catabolic process via the multivesicular body sorting 4 pathway 0 0.01804 LC vs. NC from 401 to 500 0 0.0162 ACHD vs. NC from 201 to 300 GO:0046777 protein autophosphorylation 154 5.00E-04 0.01258 LC vs. NC from 1 to 00 5.00E-04 0.01108 CHB vs. NC from 401 to 500 GO:0051006 positive regulation of lipoprotein lipase activity 5 0 0.01818 ACHD vs. NC from 51 to 150 positive regulation of membrane protein ectodomain GO:0051044 13 0 0.01098 ACHD vs. NC from 251 to 350 proteolysis protein activity GO:0051131 chaperone-mediated protein complex assembly 16 0.001 0.01375 CHB vs. NC from 1 to 100 8.00E-04 0.01263 LC vs. NC from 1 to 00 0 0.01405 LC vs. NC from 51 to 150 GO:0018105 peptidyl-serine phosphorylation 126 0 0.01865 LC vs. NC from 401 to 500 9.00E-04 0.01042 CHB vs. NC from 401 to 500 0 0.01588 LC vs. NC from 51 to 150 GO:0018107 peptidyl-threonine phosphorylation 61 2.00E-04 0.01138 LC vs. NC from 101 to 200

5.00E-04 0.01275 CHB vs. NC from 401 to 500 0 0.02774 ACHD vs. NC from 201 to 300 GO:0018108 peptidyl-tyrosine phosphorylation 67 5.00E-04 0.02726 ACHD vs. NC from 251 to 350 GO:0018119 peptidyl-cysteine S-nitrosylation 5 9.00E-04 0.01428 ACHD vs. NC from 351 to 450 3.00E-04 0.01152 LC vs. NC from 351 to 450 6.00E-04 0.01513 LC vs. NC from 401 to 500 GO:0051972 regulation of telomerase activity 47 2.00E-04 0.01085 CHB vs. NC from 1 to 100 8.00E-04 0.01139 CHB vs. NC from 51 to 150 2.00E-04 0.01697 LC vs. NC from 401 to 500 GO:0051973 positive regulation of telomerase activity 34 2.00E-04 0.01176 CHB vs. NC from 1 to 100 5.00E-04 0.01277 CHB vs. NC from 51 to 150 regulation of epidermal growth factor-activated receptor GO:0007176 21 1.00E-04 0.01263 ACHD vs. NC from 251 to 350 activity GO:0007194 negative regulation of adenylate cyclase activity 11 0 0.01101 ACHD vs. NC from 1 to 100 2.00E-04 0.01211 ACLF vs. NC from 251 to 350 GO:0007250 activation of NF-kappaB-inducing kinase activity 16 0 0.01452 CHB vs. NC from 301 to 400 0 0.01187 CHB vs. NC from 351 to 450 5.00E-04 0.01212 ACHD vs. NC from 201 to 300 GO:0007252 I-kappaB phosphorylation 10 4.00E-04 0.0101 CHB vs. NC from 301 to 400 6.00E-04 0.01958 CHB vs. NC from 101 to 200 GO:0070262 peptidyl-serine dephosphorylation 10 4.00E-04 0.02142 CHB vs. NC from 151 to 250 GO:0043550 regulation of lipid kinase activity 41 0 0.01453 ACHD vs. NC from 201 to 300 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 34 1.00E-04 0.01515 ACHD vs. NC from 201 to 300 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 25 8.00E-04 0.01575 ACHD vs. NC from 201 to 300 GO:0035606 peptidyl-cysteine S-trans-nitrosylation 2 2.00E-04 0.03061 ACHD vs. NC from 351 to 450 GO:0038083 peptidyl-tyrosine autophosphorylation 30 0 0.03838 ACHD vs. NC from 201 to 300 regulation of phosphorylation of RNA polymerase II C- GO:1901407 10 4.00E-04 0.01157 LC vs. NC from 101 to 200 terminal domain positive regulation of phosphorylation of RNA polymerase GO:1901409 8 8.00E-04 0.01315 LC vs. NC from 101 to 200 II C-terminal domain GO:2000984 negative regulation of ATP citrate synthase activity 3 7.00E-04 0.0101 CHB vs. NC from 51 to 150 5.00E-04 0.01094 ACHD vs. NC from 101 to 200 GO:0060389 pathway-restricted SMAD protein phosphorylation 12

GO:0060389 pathway-restricted SMAD protein phosphorylation 12 0 0.0119 ACHD vs. NC from 151 to 250 2.00E-04 0.01302 LC vs. NC from 51 to 150 GO:0060391 positive regulation of SMAD protein signal transduction 10 5.00E-04 0.01326 ACHD vs. NC from 151 to 250 8.00E-04 0.0101 ACLF vs. NC from 1 to 100 GO:0061097 regulation of protein tyrosine kinase activity 55 0 0.01157 ACHD vs. NC from 201 to 300 0 0.01317 ACHD vs. NC from 251 to 350 0 0.0127 ACHD vs. NC from 201 to 300 GO:0061098 positive regulation of protein tyrosine kinase activity 31 3.00E-04 0.01415 ACHD vs. NC from 251 to 350 GO:0065005 protein-lipid complex assembly 24 4.00E-04 0.01052 ACLF vs. NC from 1 to 100 0 0.01218 ACLF vs. NC from 251 to 350 GO:0070534 protein K63-linked ubiquitination 36 1.00E-04 0.01 ACLF vs. NC from 301 to 400 GO:0070936 protein K48-linked ubiquitination 48 0 0.0102 ACLF vs. NC from 251 to 350 GO:0070979 protein K11-linked ubiquitination 30 0 0.0119 LC vs. NC from 1 to 00 GO:0085020 protein K6-linked ubiquitination 8 4.00E-04 0.015 ACLF vs. NC from 301 to 400 GO:1902523 positive regulation of protein K63-linked ubiquitination 2 3.00E-04 0.0202 CHB vs. NC from 301 to 400 1.00E-04 0.01616 CHB vs. NC from 301 to 400 GO:1902916 positive regulation of protein polyubiquitination 5 6.00E-04 0.012 CHB vs. NC from 351 to 450 GO:1902949 positive regulation of tau-protein kinase activity 6 4.00E-04 0.02833 CHB vs. NC from 1 to 100 positive regulation of non-membrane spanning protein GO:1903997 5 8.00E-04 0.02626 ACHD vs. NC from 201 to 300 tyrosine kinase activity negative regulation of cyclin-dependent protein kinase GO:1904030 27 2.00E-04 0.01133 CHB vs. NC from 151 to 250 activity maintenance of unfolded protein involved in ERAD GO:1904378 3 7.00E-04 0.02061 LC vs. NC from 301 to 400 pathway GO:1990108 protein linear deubiquitination 2 6.00E-04 0.01515 CHB vs. NC from 301 to 400 negative regulation of cAMP-dependent protein kinase GO:2000480 8 9.00E-04 0.01388 ACLF vs. NC from 51 to 150 activity multi-organism 0 0.01224 ACLF vs. NC from 1 to 100 GO:0051702 interaction with symbiont 66 process 8.00E-04 0.01025 ACLF vs. NC from 51 to 150 GO:0001825 blastocyst formation 6 1.00E-04 0.0103 LC vs. NC from 301 to 400 GO:0002778 antibacterial peptide production 3 1.00E-04 0.02356 ACLF vs. NC from 51 to 150 GO:0003402 planar cell polarity pathway involved in axis elongation 1 3.00E-04 0.04166 ACLF vs. NC from 201 to 300

GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 12 0 0.01116 LC vs. NC from 201 to 300 GO:0006273 lagging strand elongation 8 0.001 0.01136 CHB vs. NC from 51 to 150 8.00E-04 0.01136 ACLF vs. NC from 1 to 100 GO:0007616 long-term memory 16 0.001 0.01136 ACLF vs. NC from 51 to 150 GO:0009051 pentose-phosphate shunt, oxidative branch 3 4.00E-04 0.0136 ACLF vs. NC from 151 to 250 0 0.01224 ACLF vs. NC from 151 to 250 pentose-phosphate shunt, non-oxidative branch 5 6.00E-04 0.01041 ACHD vs. NC from 301 to 400 GO:0010918 positive regulation of mitochondrial membrane potential 7 9.00E-04 0.01895 ACHD vs. NC from 151 to 250 GO:0014734 skeletal muscle hypertrophy 1 0 0.05208 ACLF vs. NC from 201 to 300 GO:0016322 neuron remodeling 8 1.00E-04 0.01388 ACHD vs. NC from 201 to 300 GO:0019985 translesion synthesis 39 1.00E-04 0.01087 ACHD vs. NC from 51 to 150 GO:0022614 membrane to membrane docking 5 2.00E-04 0.026 ACLF vs. NC from 101 to 200 0 0.01661 ACLF vs. NC from 51 to 150 4.00E-04 0.01322 ACLF vs. NC from 101 to 200 GO:0030260 entry into host cell 31 1.00E-04 0.01498 ACHD vs. NC from 201 to 300 2.00E-04 0.01514 ACHD vs. NC from 251 to 350 5.00E-04 0.0101 ACHD vs. NC from 201 to 300 GO:0031622 positive regulation of fever generation 6 0.001 0.0103 LC vs. NC from 251 to 350 GO:0032506 cytokinetic process 17 0 0.01188 ACHD vs. NC from 201 to 300 4.00E-04 0.01578 LC vs. NC from 101 to 200 GO:0042148 strand invasion 4 3.00E-04 0.01546 LC vs. NC from 151 to 250 GO:0043114 regulation of vascular permeability 19 5.00E-04 0.01275 ACHD vs. NC from 201 to 300 GO:0044351 macropinocytosis 7 2.00E-04 0.01178 LC vs. NC from 301 to 400 GO:0045124 regulation of bone resorption 21 3.00E-04 0.01298 ACHD vs. NC from 201 to 300 GO:0045838 positive regulation of membrane potential 9 4.00E-04 0.01587 ACHD vs. NC from 151 to 250 GO:0046326 positive regulation of glucose import 27 0 0.01646 ACHD vs. NC from 201 to 300 GO:0046331 lateral inhibition 2 2.00E-04 0.0303 ACLF vs. NC from 1 to 100 biological process GO:0046697 decidualization 7 0.001 0.0101 ACHD vs. NC from 51 to 150 GO:0046850 regulation of bone remodeling 27 8.00E-04 0.0101 ACHD vs. NC from 201 to 300 0 0.0103 LC vs. NC from 301 to 400 GO:0050915 sensory perception of sour taste 5 0 0.01041 LC vs. NC from 351 to 450 GO:0060027 convergent extension involved in gastrulation 2 2.00E-04 0.0153 CHB vs. NC from 151 to 250

GO:0060292 long term synaptic depression 5 5.00E-04 0.01458 ACLF vs. NC from 201 to 300 GO:0060346 bone trabecula formation 2 8.00E-04 0.02525 ACLF vs. NC from 1 to 100 GO:0060347 heart trabecula formation 7 3.00E-04 0.01166 LC vs. NC from 1 to 00 GO:0061028 establishment of endothelial barrier 26 0 0.01038 ACLF vs. NC from 101 to 200 GO:0071028 nuclear mRNA surveillance 13 0 0.0111 LC vs. NC from 151 to 250 GO:0072584 caveolin-mediated endocytosis 5 7.00E-04 0.03917 LC vs. NC from 401 to 500 GO:0090162 establishment of epithelial cell polarity 20 9.00E-04 0.0101 ACHD vs. NC from 201 to 300 GO:0090170 regulation of Golgi inheritance 4 4.00E-04 0.06185 LC vs. NC from 401 to 500 GO:0090344 negative regulation of cell aging 15 0 0.01305 LC vs. NC from 251 to 350 GO:0090399 replicative senescence 11 8.00E-04 0.01799 LC vs. NC from 351 to 450 8.00E-04 0.01458 ACLF vs. NC from 201 to 300 GO:0090557 establishment of endothelial intestinal barrier 10 0.001 0.01443 LC vs. NC from 201 to 300 regulation of cardiac muscle cell action potential involved in GO:0098909 7 2.00E-04 0.0102 ACHD vs. NC from 351 to 450 regulation of contraction GO:0110076 negative regulation of ferroptosis 1 5.00E-04 0.03061 ACLF vs. NC from 251 to 350 GO:1900221 regulation of amyloid-beta clearance 10 0 0.01818 ACLF vs. NC from 1 to 100 GO:1900223 positive regulation of amyloid-beta clearance 6 1.00E-04 0.02356 ACLF vs. NC from 1 to 100 GO:1901386 negative regulation of voltage-gated calcium channel activity 4 9.00E-04 0.0101 ACHD vs. NC from 1 to 100 0.001 0.01 CHB vs. NC from 351 to 450 GO:1901877 negative regulation of calcium ion binding 2 0 0.01515 CHB vs. NC from 401 to 500 GO:1901897 regulation of relaxation of cardiac muscle 6 0 0.01178 ACLF vs. NC from 51 to 150 GO:1902336 positive regulation of retinal ganglion cell axon guidance 2 7.00E-04 0.0202 ACHD vs. NC from 1 to 100 regulation of calcium ion transmembrane transport via high GO:1902514 9 0 0.01122 ACLF vs. NC from 1 to 100 voltage-gated calcium channel GO:1903671 negative regulation of sprouting angiogenesis 21 4.00E-04 0.01058 ACLF vs. NC from 51 to 150 GO:1904425 negative regulation of GTP binding 1 9.00E-04 0.0202 ACLF vs. NC from 1 to 100 GO:2000773 negative regulation of cellular senescence 11 0 0.01593 LC vs. NC from 251 to 350

Supplementary Table 16. Information on 62 overlapping DE genes in a pairwise comparison of the CHB, LC, ACHD and ACLF groups

ACLF vs. CHB ACLF vs. LC ACHD vs. CHB ACHD vs. LC Gene Ensembl Gene ID Symbol log2FC P valuea P adjb log2FC P valuea P adjb log2FC P valuea P adjb log2FC P valuea P adjb

ENSG00000167680 SEMA6B 3.775 3.04E-23 5.54E-19 3.441 1.58E-13 1.45E-10 2.152 1.88E-12 1.10E-08 1.418 3.26E-04 6.23E-03 ENSG00000132170 PPARG 2.524 1.71E-18 1.56E-14 2.245 1.05E-14 1.53E-11 1.896 1.03E-07 5.39E-05 1.615 7.77E-06 4.21E-04 ENSG00000148926 ADM 2.256 1.24E-14 4.54E-11 2.113 1.49E-11 5.48E-09 1.629 3.91E-06 6.68E-04 1.468 9.23E-05 2.61E-03 ENSG00000204103 MAFB 1.788 2.25E-12 5.14E-09 1.843 6.16E-11 1.59E-08 1.724 5.54E-08 3.41E-05 1.774 3.99E-07 4.64E-05 ENSG00000185339 TCN2 1.829 3.36E-11 6.80E-08 2.194 2.00E-15 4.41E-12 1.360 4.32E-05 3.34E-03 1.704 2.39E-07 3.20E-05 ENSG00000184557 SOCS3 1.706 2.94E-10 3.09E-07 1.595 5.32E-08 3.47E-06 1.709 1.75E-07 7.44E-05 1.603 5.35E-06 3.22E-04 ENSG00000142657 PGD 1.111 2.88E-10 3.09E-07 1.030 1.59E-08 1.40E-06 0.900 7.43E-05 4.61E-03 0.818 4.63E-04 7.87E-03 ENSG00000163221 S100A12 1.745 4.87E-10 4.28E-07 1.827 1.01E-09 1.53E-07 1.239 8.61E-06 1.14E-03 1.282 6.08E-06 3.50E-04 ENSG00000157557 ETS2 1.663 7.03E-10 5.83E-07 1.817 5.98E-10 1.01E-07 1.366 2.61E-06 4.92E-04 1.495 1.71E-06 1.37E-04 ENSG00000108950 FAM20A 2.283 1.12E-09 8.20E-07 2.597 1.55E-09 2.16E-07 1.549 5.48E-05 3.85E-03 1.711 5.59E-05 1.83E-03 ENSG00000137393 RNF144B 1.466 1.42E-09 9.94E-07 1.379 2.26E-07 1.03E-05 1.416 1.31E-06 3.21E-04 1.326 3.55E-05 1.32E-03 ENSG00000162512 SDC3 1.497 2.73E-09 1.66E-06 1.597 5.44E-10 9.46E-08 1.207 9.27E-06 1.22E-03 1.297 9.54E-07 8.78E-05 ENSG00000109321 AREG 1.958 3.30E-09 1.88E-06 2.340 6.76E-08 4.17E-06 1.375 4.09E-05 3.24E-03 1.668 4.41E-04 7.65E-03 ENSG00000143162 CREG1 1.147 3.41E-09 1.88E-06 1.306 2.38E-11 7.73E-09 0.937 1.81E-05 1.96E-03 1.091 2.48E-07 3.28E-05 ENSG00000121316 PLBD1 1.415 7.03E-09 3.12E-06 1.553 1.37E-10 3.14E-08 1.127 3.11E-05 2.73E-03 1.257 5.05E-07 5.51E-05 ENSG00000139572 GPR84 1.520 2.08E-08 7.00E-06 1.438 9.25E-07 3.23E-05 1.258 4.07E-05 3.24E-03 1.170 3.29E-04 6.26E-03 ENSG00000140044 JDP2 1.557 2.26E-08 7.37E-06 1.661 3.56E-08 2.51E-06 1.307 6.61E-05 4.27E-03 1.396 7.26E-05 2.17E-03 ENSG00000139832 RAB20 1.312 2.96E-08 8.98E-06 1.673 6.39E-13 4.78E-10 1.223 5.46E-05 3.85E-03 1.582 1.40E-07 2.20E-05 ENSG00000103187 COTL1 0.827 4.45E-08 1.25E-05 0.683 3.31E-06 8.92E-05 0.910 7.17E-06 1.03E-03 0.772 9.07E-05 2.58E-03 ENSG00000170017 ALCAM 0.953 6.43E-08 1.63E-05 1.074 1.76E-08 1.52E-06 0.792 2.53E-06 4.82E-04 0.907 1.01E-06 9.14E-05 ENSG00000154127 UBASH3B 0.644 7.99E-08 1.86E-05 0.730 7.54E-09 7.48E-07 0.539 1.45E-04 7.20E-03 0.624 3.35E-05 1.27E-03 ENSG00000178719 GRINA 0.787 1.17E-07 2.58E-05 0.660 2.56E-04 2.65E-03 1.154 4.78E-06 7.77E-04 1.042 2.97E-04 5.80E-03 ENSG00000163220 S100A9 1.329 1.29E-07 2.73E-05 1.300 3.50E-07 1.46E-05 1.170 7.16E-05 4.51E-03 1.141 8.82E-05 2.52E-03 ENSG00000172292 CERS6 0.681 1.28E-07 2.73E-05 0.830 8.44E-09 8.18E-07 0.663 6.47E-07 2.02E-04 0.807 2.93E-07 3.74E-05 ENSG00000107745 MICU1 0.696 2.28E-07 4.29E-05 0.588 2.62E-05 4.41E-04 0.807 3.27E-06 5.83E-04 0.701 9.47E-05 2.66E-03 ENSG00000168615 ADAM9 1.088 2.36E-07 4.35E-05 1.269 9.39E-10 1.47E-07 0.865 8.49E-05 5.03E-03 1.043 1.02E-07 1.67E-05 ENSG00000115919 KYNU 1.191 2.48E-07 4.53E-05 1.395 5.17E-08 3.39E-06 0.863 1.73E-04 8.10E-03 1.048 5.69E-05 1.85E-03 ENSG00000143546 S100A8 1.377 3.04E-07 5.08E-05 1.399 5.86E-07 2.23E-05 1.245 2.73E-05 2.52E-03 1.260 2.35E-05 9.62E-04 ENSG00000152766 ANKRD22 1.446 5.52E-07 8.12E-05 1.385 2.96E-05 4.84E-04 2.003 6.95E-10 1.48E-06 1.952 1.56E-07 2.33E-05

ENSG00000172594 SMPDL3A 1.049 6.47E-07 9.22E-05 1.058 2.54E-06 7.20E-05 0.983 1.20E-04 6.29E-03 0.990 2.76E-04 5.52E-03 ENSG00000130830 MPP1 0.789 1.68E-06 1.97E-04 1.088 2.61E-11 8.16E-09 1.190 4.07E-05 3.24E-03 1.495 9.05E-07 8.45E-05 ENSG00000060558 GNA15 0.913 1.72E-06 1.99E-04 0.931 3.66E-06 9.60E-05 1.125 7.81E-08 4.48E-05 1.142 1.52E-07 2.30E-05 ENSG00000176454 LPCAT4 -0.646 2.71E-06 2.82E-04 -0.725 1.63E-07 7.97E-06 -0.617 5.70E-05 3.92E-03 -0.696 2.99E-06 2.10E-04 ENSG00000175155 YPEL2 1.523 3.15E-06 3.13E-04 2.186 2.60E-09 3.17E-07 1.687 8.70E-10 1.70E-06 2.337 3.92E-14 1.79E-10 ENSG00000162711 NLRP3 0.884 5.00E-06 4.47E-04 1.238 8.68E-10 1.38E-07 0.924 6.66E-05 4.27E-03 1.274 9.11E-08 1.54E-05 ENSG00000065911 MTHFD2 0.733 5.57E-06 4.77E-04 0.743 2.40E-06 6.90E-05 0.807 9.92E-06 1.25E-03 0.820 1.02E-06 9.19E-05 ENSG00000177706 FAM20C 0.985 7.12E-06 5.77E-04 0.951 5.88E-05 8.22E-04 1.399 4.06E-08 3.01E-05 1.368 5.31E-07 5.68E-05 ENSG00000136048 DRAM1 1.058 8.46E-06 6.48E-04 1.170 1.21E-05 2.40E-04 0.976 5.70E-07 1.91E-04 1.065 8.92E-06 4.68E-04 ENSG00000169504 CLIC4 0.770 8.76E-06 6.63E-04 0.898 3.29E-07 1.39E-05 0.764 3.80E-05 3.10E-03 0.892 8.56E-07 8.17E-05 ENSG00000147475 ERLIN2 0.533 1.08E-05 7.74E-04 0.481 1.41E-04 1.64E-03 0.553 5.75E-06 8.79E-04 0.500 7.11E-05 2.16E-03 ENSG00000023330 ALAS1 0.689 1.16E-05 8.16E-04 0.702 1.15E-05 2.31E-04 0.755 1.07E-04 5.82E-03 0.770 8.49E-05 2.45E-03 ENSG00000108100 CCNY 0.481 1.21E-05 8.43E-04 0.533 4.46E-06 1.12E-04 0.477 2.08E-04 9.24E-03 0.528 1.02E-04 2.79E-03 ENSG00000111961 SASH1 1.093 2.59E-05 1.43E-03 1.082 1.69E-04 1.90E-03 0.973 2.68E-05 2.50E-03 0.938 3.65E-04 6.66E-03 ENSG00000198720 ANKRD13B -0.761 2.69E-05 1.47E-03 -1.011 6.38E-07 2.37E-05 -0.836 1.24E-04 6.43E-03 -1.081 1.14E-05 5.56E-04 ENSG00000142173 COL6A2 -1.098 2.91E-05 1.56E-03 -1.258 9.01E-06 1.95E-04 -1.160 6.46E-05 4.24E-03 -1.315 2.13E-05 8.95E-04 ENSG00000090339 ICAM1 1.000 3.10E-05 1.63E-03 1.299 2.40E-07 1.08E-05 1.435 2.50E-06 4.81E-04 1.746 4.70E-08 9.52E-06 ENSG00000078124 ACER3 1.259 3.38E-05 1.72E-03 1.364 7.60E-05 1.01E-03 1.442 3.40E-05 2.90E-03 1.537 9.23E-05 2.61E-03 ENSG00000160271 RALGDS -0.645 3.58E-05 1.77E-03 -0.831 3.25E-07 1.38E-05 -0.649 7.89E-05 4.78E-03 -0.833 7.23E-07 7.11E-05 ENSG00000121064 SCPEP1 0.660 4.62E-05 2.13E-03 0.783 2.54E-06 7.20E-05 0.743 2.31E-04 9.88E-03 0.866 2.41E-05 9.81E-04 ENSG00000111144 LTA4H 0.866 5.52E-05 2.38E-03 1.017 2.26E-06 6.56E-05 0.853 7.67E-05 4.69E-03 1.006 2.20E-07 3.00E-05 ENSG00000072062 PRKACA 0.524 5.55E-05 2.39E-03 0.515 1.33E-04 1.57E-03 0.597 6.95E-05 4.41E-03 0.588 1.23E-04 3.21E-03 ENSG00000114388 NPRL2 -0.466 8.77E-05 3.22E-03 -0.756 4.39E-09 4.84E-07 -0.425 1.70E-04 8.04E-03 -0.714 2.70E-08 6.48E-06 ENSG00000104765 BNIP3L 0.807 1.82E-04 5.35E-03 0.809 1.63E-04 1.85E-03 1.310 1.22E-04 6.35E-03 1.357 1.67E-04 3.93E-03 ENSG00000198933 TBKBP1 -0.746 2.07E-04 5.82E-03 -1.061 1.28E-07 6.64E-06 -0.860 6.09E-05 4.07E-03 -1.181 3.35E-09 1.38E-06 ENSG00000168778 TCTN2 -0.741 2.12E-04 5.92E-03 -0.738 6.96E-04 5.75E-03 -1.091 1.08E-08 1.15E-05 -1.084 3.33E-07 4.06E-05 ENSG00000115523 GNLY -0.989 2.62E-04 6.81E-03 -1.363 6.76E-06 1.56E-04 -1.122 1.06E-06 2.74E-04 -1.482 3.26E-08 7.23E-06 ENSG00000162444 RBP7 0.807 3.19E-04 7.65E-03 0.871 4.12E-04 3.85E-03 0.899 1.26E-04 6.47E-03 0.953 2.39E-04 4.99E-03 ENSG00000162545 CAMK2N1 -0.995 3.21E-04 7.66E-03 -1.217 5.64E-05 7.96E-04 -1.171 1.11E-04 5.96E-03 -1.388 2.23E-05 9.23E-04 ENSG00000109320 NFKB1 0.297 3.28E-04 7.76E-03 0.331 1.59E-04 1.82E-03 0.500 9.60E-05 5.41E-03 0.534 9.95E-05 2.74E-03 ENSG00000143842 SOX13 -0.985 3.45E-04 7.97E-03 -1.085 2.58E-04 2.66E-03 -1.343 5.48E-08 3.41E-05 -1.439 1.65E-08 4.42E-06 ENSG00000204991 SPIRE2 -0.911 3.48E-04 8.02E-03 -1.099 1.02E-05 2.13E-04 -1.307 8.23E-07 2.32E-04 -1.527 1.40E-11 2.14E-08 ENSG00000069399 BCL3 0.780 3.69E-04 8.35E-03 1.314 2.51E-08 1.97E-06 1.061 7.42E-05 4.61E-03 1.589 2.98E-08 6.84E-06 ACLF, acute-on-chronic liver failure; ACHD, acute-on-chronic hepatic dysfunction; LC, liver cirrhosis; CHB, chronic hepatitis B; NC, normal control. a P value computed using DESeq2. b Adjusted P value calculated using the Benjamini and Hochberg procedure.

Supplementary Table 17. Clinical characteristics of patients in the validation group.

ACLF ACHD LC CHB NC Characteristics (n=110) (n=60) (n=60) (n=60) (n=45) Age (yrs.) 46.3±12.2 45.2±13.9 46.1±9.8 42.7±8.2 43.4±12.0 Male (No.) 88.0% (88) 78.0% (39) 70.0% (35) * 88.0% (44) 48.9% (22) *** HBV DNA level (IU/mL) significancea significancea significancea ≤ 2×102 4.5% (5) 18.4% (11) 90.0% (54) 80.0% (48) NA 2×102 - 2×106 64.6% (71) 53.3% (32) 10.0% (6) 13.3% (8) NA > 2×106 30.9% (34) 28.3% (17) 0.0% (0) 6.7% (4) NA Laboratory data Alanine aminotransferase (U/L) 252.0 [90.7, 609.0] 179.5 [73.0, 600.2] 24.5 [17.7, 33.2] *** 23.1 [16.7, 29.3] *** 19.0 [14.0, 24.0] *** Aspartate aminotransferase (U/L) 157.0 [105.5, 321.0] 128.0 [65.5, 351.3] 24.0 [19.0, 30.0] *** 21.5 [19.0, 27.0] *** 20.0 [18.0, 24.0] *** Albumin (g/L) 31.3 [28.0, 33.8] 32.4 [30.0, 36.1] * 47.6 [45.8, 48.8] *** 48.6 [46.4, 50.4] *** 47.7 [46.1, 49.0] *** Total bilirubin (µmol/L) 351.2 [262.8, 436.2] 186.0 [138.3, 288.4] *** 13.1 [11.0, 17.0] *** 13.0 [8.7, 16.0] *** 11.0 [8.0, 16.0] *** Alkaline phosphatase (U/L) 134.0 [109.2, 162.0] 120.5 [101.7, 144.7] * 70.0 [56.5, 89.2] *** 63.0 [48.0, 79.2] *** 66.5 [55.7, 84.0] *** γ-glutamyl transpeptidase (U/L) 77.7 [54.4, 113.7] 97.0 [53.5, 142.2] 22.0 [16.7, 37.2] *** 20.0 [13.0, 33.2] *** 19.0 [12.0, 26.0] *** Creatinine (μmol/L) 67.0 [58.0, 81.7] 66.0 [57.7, 76.0] 70.0 [62.5, 81.0] 75.0 [65.0, 84.5] 63.0 [56.0, 76.0] Sodium (mmol/L) 137.0 [135.0, 139.0] 138.0 [137.0, 140.0] ** 141.0 [140.0, 142.0] *** 141.0 [140.0, 143.0] *** 141.0 [140.0, 142.3] *** White blood cell count (109/L) 7.6 [6.2, 10.4] 6.2 [4.2, 7.6] *** 5.20 [4.0, 6.30] *** 5.4 [4.5, 6.2] *** 6.1 [5.2, 6.9] *** Haemoglobin (g/L) 124.0 [115.2, 136.0] 133.0 [116.5, 145.5] 153.0 [139.50, 158.0]*** 151.0 [139.0, 161.0] *** 149.0 [136.0, 160.0] *** Haematocrit (%) 35.6 [32.4, 38.6] 37.6 [32.7, 42.9] * 45.3 [41.9, 47.1] *** 44.3 [41.3, 46.6] *** 44.1 [40.7, 47.8] *** Platelet count (109/L) 111.5 [72.5, 144.7] 141.0 [79.0, 187.0] * 160.0 [117.7, 208.0] *** 174.0 [138.5, 214.5] *** 218.5 [188.5, 253.0] *** INR 2.3 [1.8, 3.0] 1.3 [1.2, 1.7] *** 1.0 [1.0, 1.0] *** 0.97 [0.94, 1.02] *** NA Alpha fetoprotein (μg/L) 86.4 [29.4, 235.3] 77.1 [12.6, 285.7] 2.2 [1.8, 2.7] *** 2.5 [1.9, 3.4] *** 2.7 [2.0, 4.0] *** Organ failure (No.) Liver 93.6% (103) 38.3% (23) *** 0*** 0*** 0*** Coagulation 42.7% (47) 6.7% (4) *** 0*** 0*** 0*** Kidney 7.3% (8) 0 0 0 0 Cerebral 4.5% (5) 0* 0* 0* 0 Lung 1.8% (2) 0 0 0 0 Circulation 0.9% (1) 0 0 0 0

Severity scores COSSH-ACLFs 6.1 [5.7, 6.7] NA NA NA NA CLIF-C ACLFs 41.7 [37.2, 45.8] NA NA NA NA MELD 24.8 [20.9, 29.3] NA NA NA NA Transplant-free mortality rate (number of deceased patients) # 28-day 31.5% (29) 1.7% (1)*** 0*** 0*** NA 90-day 46.3% (38) 1.7% (1)*** 0*** 0*** NA NOTE. Data are presented as the means ± SD, medians with [p25, p75], or percentages (numbers of patients). ACLF, acute-on-chronic liver failure; ACHD, acute-on-chronic hepatic dysfunction; LC, liver cirrhosis; CHB, chronic hepatitis B; NC, normal control. COSSH-ACLFs, COSSH-ACLF score; CLIF-C ACLFs, CLIF Consortium ACLF score; MELD, Model for End-Stage Liver Disease. #Twelve patients with ACLF underwent liver transplantation and were considered lost to follow-up in the mortality rate calculation. Six patients with ACLF were lost to the 28-day follow-up analysis, and 16 patients were lost to the 90-day follow-up analysis. a P value (<0.001) for comparisons of the HBV DNA distribution between the ACHD/LC/CHB/NC and ACLF groups. * P <0.05, ** P<0.01 and *** P<0.001 for comparisons between the ACHD/LC/CHB/NC and ACLF groups.

Li J, et al. Gut 2021;0:1–13. doi: 10.1136/gutjnl-2020-323395