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Supplemental Table I Differentially Regulated Transcripts Between

Supplemental Table I Differentially Regulated Transcripts Between

Supplemental Table I 2 Fold Change decreases in LTßRKO1

UniGene ID Build 167 (28 Expression Oct 2007) / profile (Unigene Norm Norm FC Probe Set ID Representati Symbol Gene Name tissues 03.2008) wt ko ve Public ID 1438879_at Mm.453259 --- CDNA clone IMAGE:30032691 1 brain 0.02 0.01 2.00 1439879_at Mm.458966 --- Transcribed locus 1 eye 0.02 0.01 2.00 1442067_at Mm.453423 --- Transcribed locus 1 eye 0.04 0.01 2.74 1443026_at Mm.451175 --- RIKEN clone:B930006H01 1 brain 0.03 0.01 2.00 1444205_at Mm.450726 --- RIKEN clone:D930036I15 1 thymus 0.05 0.02 2.74 1446242_at Mm.449920 --- Transcribed locus 1 embryo 0.02 0.01 2.45 1446253_at Mm.397836 --- RIKEN clone:6330445G12 1 eye 0.04 0.01 3.00 1449806_at Mm.367683 --- Transcribed locus 1 embryo 0.03 0.01 2.83 1458750_at Mm.448232 --- RIKEN clone:D930028N23 1 mammary gland 0.04 0.02 2.24 1459975_at Mm.90213 --- Transcribed locus 1 blood 0.03 0.01 2.12 1458331_x_at Mm.200622 --- Transcribed locus 1 epididymis 0.18 0.04 4.49 1453709_at Mm.426933 3426406O18Rik RIKEN 3426406O18 gene 1 intestine 0.02 0.01 2.45 1432050_at Mm.382588 4930571B16Rik RIKEN 4930571B16 gene 1 testis 0.02 0.01 2.45 1441258_at Mm.242899 AF529169 cDNA sequence AF529169 1 brain 0.03 0.01 2.45 1421552_at Mm.4353 Cdx4 caudal type homeo box 4 1 heart 0.02 0.01 2.00 1432406_at Mm.390064 Ces7 carboxylesterase 7 1 prostate 0.09 0.03 3.00 Mm.290600 chloride channel calcium activated 1451823_at Clca4 4 1 intestine 0.14 0.06 2.28 Mm.442050 chloride channel calcium activated 1439727_at Clca6 6 1 intestine 0.09 0.03 2.53 Mm.79402 C-type lectin domain family 12, 1429925_at Clec12b member B 1 testis 0.05 0.02 2.74 1428738_a_at Mm.459796 D14Ertd449e D14Ertd449e 1 kidney 0.71 0.14 4.89 Mm.86948 eosinophil-associated, 1421802_at Ear1 ribonuclease A family, 1 1 embryo 0.32 0.16 2.03 1425886_at Mm.150496 Fev FEV (ETS oncogene family) 1 pituitary gland 0.03 0.01 2.00 1452590_a_at Mm.464777 Plac9 placenta specific 9 1 eye 0.20 0.05 3.74 Mm.429131 similar to RIKEN 1110051B16 1429099_at LOC100039227 gene 1 embryo 0.06 0.02 2.31 1454264_at Mm.195782 LOC100042581 similar to CG4877-PA 1 tongue 0.13 0.03 4.54 Mm.271796 matrilin 1, cartilage matrix protein 1418477_at Matn1 1 1 nasopharynx 0.07 0.02 4.00 1419391_at Mm.16528 Myog myogenin 1 muscle 0.05 0.01 4.90 1425083_at Mm.157751 Otor otoraplin 1 inner ear 0.04 0.02 2.12 1422939_at Mm.337362 Serpinb3b / serine (or cysteine) peptidase 1 embryo 0.11 0.05 2.33 Serpinb3c inhibitor, clade B, member 3C / 3B Mm.448075 / 1453370_at BB489500 Troap trophinin associated protein 1 stomach 0.03 0.01 2.12 1421781_at Mm.4453 Upk2 uroplakin 2 1 eye 0.05 0.02 2.89 1442997_at Mm.446025 --- RIKEN clone:C130012D05 2 kidney, testis 0.02 0.01 2.45 1443090_at Mm.443002 --- RIKEN clone:C130007L10 2 muscle, prostate 0.04 0.02 2.12 1443337_at Mm.448265 --- RIKEN clone:E030012P20 2 eye, lung 0.03 0.02 2.00 Mm.442080 / 1444441_at AW490909 --- Transcribed locus 2 brain, skin 0.03 0.01 3.16 1446713_at Mm.453154 --- Transcribed locus 2 heart, pancreas 0.02 0.01 2.00 1460061_at Mm.437581 --- RIKEN clone:6430530M09 2 brain, mammary gland 0.03 0.01 3.00 1456203_at Mm.33740 1110020A10Rik RIKEN 1110020A10 gene 2 skin, vagina 0.04 0.02 2.00 Mm.307159 extraembr 1430852_at 1600029I14Rik RIKEN 1600029I14 gene 2 tissue, 0.03 0.01 3.00 mammary gland Mm.75315 muscle, 1453547_at 1810046K07Rik RIKEN 1810046K07 gene 2 pancreas 0.18 0.04 4.64

1 Differentially regulated transcripts between knockout and wild-type mTECs for two-fold change in expression level as analyzed in GeneSpring software, with data normalized per gene and per chip and without filtering in expression level. TSAs are organized according to their known expression profile (Unigene database) from transcripts expressed in the lowest (1) to the highest (5) number of different tissues. 1460478_at Mm.307035 2200002J24Rik RIKEN 2200002J24 gene 2 stomach, testis 0.04 0.02 2.24 1435111_at Mm.459021 2310011E23Rik RIKEN 2310011E23 gene 2 skin, tongue 0.06 0.03 2.11 1435678_at Mm.45203 2610017I09Rik RIKEN 2610017I09 gene 2 brain, testis 0.05 0.02 2.65 1453558_at Mm.156068 4930504H06Rik RIKEN 4930504H06 gene 2 brain, testis 0.03 0.01 2.12 1436563_at Mm.443621 4932441J04Rik RIKEN 4932441J04 gene 2 brain, testis 0.03 0.01 2.12 1436250_at Mm.103494 5430405G05Rik RIKEN 5430405G05 gene 2 brain, inner ear 0.04 0.02 2.24 Mm.359721 spinal cord, 1443994_at 6030407O03Rik RIKEN 6030407O03 gene 2 testis 0.05 0.01 3.87 1453661_at Mm.381338 9130403I23Rik RIKEN 9130403I23 gene 2 connective 0.03 0.01 2.12 tissue, thymus Mm.446910 epididymis, 1432567_at A430105D02Rik RIKEN A430105D02 gene 2 thymus 0.02 0.01 2.45 1440455_at Mm.459462 AI848599 AI848599 2 brain, pancreas 0.04 0.02 2.24 1457717_at Mm.443881 AI987986 AI987986 2 kidney, 0.06 0.01 4.24 mammary gland 1452478_at Mm.296528 Alpk2 alpha-kinase 2 2 heart, skin 0.11 0.04 2.55 1458500_at Mm.320428 AU021034 AU021034 2 brain, heart 0.03 0.01 2.12 1434163_at Mm.326336 AU024076 AU024076 2 ovum, ovary 0.04 0.01 3.87 1460064_at Mm.453091 BC028789 BC028789 2 BM, thymus 0.03 0.01 2.45 1436285_at Mm.248902 Ccdc113 coiled-coil domain containing 113 2 brain, testis 0.02 0.01 2.00 1427372_at Mm.6216 Cyp27b1 cytochrome P450, family 27, 2 brain, kidney 0.03 0.01 2.12 subfamily b, polypeptide 1 1452501_at Mm.42100 Cyp2c38 cytochrome P450, family 2, 2 liver, muscle 0.03 0.01 2.00 subfamily c, polypeptide 38 Mm.27982 developmental pluripotency- 2 1424295_at Dppa3 associated 3 ovum, ovary 0.33 0.05 6.69 Mm.139314 developmental pluripotency 2 1416552_at Dppa5 associated 5 ovary, testis 0.12 0.05 2.53 1459259_at Mm.38101 EG328264 predicted gene, EG328264 2 LN, skin 0.02 0.01 2.45 1454911_at Mm.441401 EG382106 predicted gene, EG382106 2 ovum, ovary 0.02 0.01 2.00 1449994_at Mm.197319 Epgn epithelial mitogen 2 eye, tongue 0.17 0.08 2.14 1436437_at Mm.297596 Gm97 gene model 97, (NCBI) 2 ovum, ovary 0.03 0.01 3.00 1450330_at Mm.874 Il10 interleukin 10 2 blood, BM 0.06 0.02 2.96 1420490_at Mm.440887 Klk1b16 kallikrein 1-related peptidase b16 2 intestine, 0.27 0.09 3.00 salivary gland 1420550_at Mm.158176 Lce1f late cornified envelope 1F 2 skin, tongue 0.11 0.04 2.45 Mm.394901 Hypothetical protein 1443888_at LOC100043802 LOC100043802 2 brain, ovary 0.03 0.01 2.12

Mm.461707 hypothetical protein inner ear, 1445722_at / BB200250 LOC100045347 LOC100045347 2 thymus 0.03 0.01 2.83 1460283_at Mm.143718 Mefv Mediterranean fever 2 BM, intestine 0.03 0.02 2.00 1418215_at Mm.2682 Mep1b meprin 1 beta 2 intestine, kidney 0.09 0.04 2.25 Mm.138520 oxoglutarate (alpha-ketoglutarate) 1456989_at Oxgr1 receptor 1 2 kidney, liver 0.03 0.01 3.46 1418759_at Mm.8019 Ptpn20 protein tyrosine phosphatase, non- 2 brain, testis 0.02 0.01 2.00 receptor type 20 1423410_at Mm.2688 Meig1 meiosis expressed gene 1 2 brain, testis 0.03 0.01 2.45 1438617_at Mm.211704 Serpina7 Serine (or cysteine) peptidase 2 liver, pancreas 0.09 0.04 2.19 inhibitor, clade A, member 7 Mm.128597 spinal cord, 1430113_at Sh2d6 SH2 domain containing 6 2 testis 0.11 0.01 7.65 Mm.441070 5 1440834_at Slc5a10 (sodium/glucose ), 2 kidney, spleen 0.04 0.01 4.00 member 10 1455838_at Mm.29788 Slfnl1 schlafen like 1 2 eye, testis 0.02 0.01 2.00 Mm.25089 brain, pancreas, 1436092_at --- Transcribed locus 3 spinal cord 0.13 0.06 2.10 Mm.296453 BM, kidney, 1440121_at --- RIKEN clone:D630050A03 3 pancreas 0.03 0.01 2.00 Mm.443628 eye, pineal 1441362_at --- Transcribed locus 3 gland, prostate 0.04 0.01 4.00 Mm.151250 eye, heart, sympathetic 1444444_at --- RIKEN clone:6330524O11 3 ganglion 0.02 0.01 2.00 Mm.449557 eye, skin, 1447176_at --- Transcribed locus 3 thymus 0.04 0.02 2.00 Mm.27791 brain, innear 1428993_at 1110017I16Rik RIKEN 1110017I16 gene 3 ear, joint 0.08 0.03 2.79 Mm.54544 extraembr tissue, mammary gland, 1430162_at 3830417A13Rik RIKEN 3830417A13 gene 3 testis 0.02 0.01 2.00 1440995_at Mm.389985 6430531B16Rik RIKEN 6430531B16 gene 3 brain, skin, testis 0.03 0.02 2.00 1443531_at Mm.291225 A930005I04Rik RIKEN A930005I04 gene 3 brain, eye, ovary 0.02 0.01 2.45 Mm.202309 brain, kidney, 1441978_at Aqp6 aquaporin 6 3 spleen 0.03 0.01 2.00 Mm.196417 achaete-scute complex homolog- extraembr 1432018_at Ascl2 like 2 3 tissue, intestine, 0.02 0.01 2.00 liver Mm.436987 ovum, eye, 1443946_s_at AU040972 AU040972 3 tongue 0.06 0.02 3.16 1422777_at Mm.57154 C1ql1 complement component 1, q 3 BM, brain, eye 0.04 0.01 2.83 subcomponent-like 1 Mm.337666 eye, liver, 1442612_at C730036E19Rik RIKEN C730036E19 gene 3 muscle 0.02 0.01 2.00 1449881_a_at Mm.103619 Casr calcium-sensing receptor kidney, 3 pancreas, testis 0.08 0.04 2.05 1449882_a_at Mm.103619 Casr calcium-sensing receptor 0.02 0.01 2.00 1419011_at Mm.86656 Cryba2 crystallin, beta A2 3 eye, pituitary 0.04 0.02 2.24 gland, tongue Mm.14098 mammary gland, 1419731_at Cyp2b19 cytochrome P450, family 2, pituitary gland, subfamily b, polypeptide 19 3 skin 0.10 0.05 2.08 Mm.347413 intestine, lung, 1421865_at Dbil5 diazepam binding inhibitor-like 5 3 testis 0.02 0.01 2.45 Mm.4873 brain, inner ear, 1449863_a_at Dlx5 distal-less homeobox 5 3 joint 0.04 0.02 2.31 Mm.103737 brain, lung, 1436329_at Egr3 early growth response 3 3 testis 0.20 0.10 2.05 Mm.388925 gamma-aminobutyric acid (GABA- brain, eye, 1449980_a_at Gabrd A) receptor, subunit delta 3 pituitary gland 0.03 0.01 2.83 Mm.456 intestine, 1419020_at Gif gastric intrinsic factor 3 stomach, tongue 0.04 0.02 2.24 Mm.79079 lung, testis, 1440692_at Gm364 gene model 364, (NCBI) 3 thymus 0.02 0.01 2.00 Mm.259262 killer cell lectin-like receptor inner ear, skin, 1457722_at Klrb1f subfamily B member 1F 3 thymus 0.03 0.01 3.46 Mm.415 eye, pancreas, 1456004_x_at Iapp islet amyloid polypeptide 3 thymus 0.11 0.05 2.19 Mm.241682 brain, eye, 1437201_at Lrrc4c leucine rich repeat containing 4C 3 spinal cord 0.08 0.04 2.16 Mm.235807 protein tyrosine phosphatase, brain, eye, 1450174_at Ptprt receptor type, T 3 pancreas 0.02 0.01 2.00 Mm.38271 brain, liver, 1442263_at Rgs13 regulator of G-protein signaling 13 3 thymus 0.14 0.02 8.00 Mm.326723 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 1429285_at Serpina9 antiproteinase, antitrypsin), brain, skin, member 9 3 tongue 0.07 0.03 2.48 Mm.25246 serine peptidase inhibitor, Kazal intestine, 1427119_at Spink4 type 4 3 pancreas, stomach 0.14 0.07 2.02 1429552_at Mm.441823 Wdr16 WD repeat domain 16 3 intestine, muscle, testis 0.02 0.01 2.45 Mm.440553 Brain, eye, kidney, 1435197_at --- CDNA clone IMAGE:6822296 4 mammary gland 0.07 0.03 2.65 Mm.441364 brain, lung, 1436459_at --- CDNA clone IMAGE:3667370 4 mammary gland, 0.04 0.02 2.31 ovary Mm.448159 heart, kidney, pancreas, 1439299_at --- RIKEN clone:D630033G03 4 sympathetic 0.02 0.01 2.00 ganglion Mm.441674 brain, intestine, 1439828_at --- Transcribed locus 4 pituitary gland, 0.02 0.01 2.00 thymus Mm.410527 dorsal root 4 ganglion, heart, 0.03 0.02 2.00 1439928_at --- Transcribed locus ovary, vagina Mm.441635 brain, eye, 1443230_at --- CDNA clone IMAGE:6514950 4 mammary gland, 0.04 0.02 2.00 skin 1428705_at Mm.46470 1700007K13Rik RIKEN 1700007K13 gene 4 brain, liver, lung, 0.04 0.02 2.58 testis 1430642_at Mm.102196 2900001G08Rik RIKEN 2900001G08 gene 4 lung, pancreas, 0.02 0.01 2.00 spinal cord, stomach Mm.265384 brain, eye, 1436231_at 2900052N01Rik RIKEN 2900052N01 gene 4 mammary gland, 0.04 0.01 3.16 spinal cord Mm.294342 ovum, conective 1456711_at 4932425I24Rik RIKEN 4932425I24 gene 4 tissue, heart, 0.05 0.02 3.06 testis Mm.380815 brain, eye, 1440849_at 6330417G04Rik RIKEN 6330417G04 gene 4 mammary gland, 0.03 0.01 3.00 pancreas Mm.318874 brain, eye, Adherens junction associated kidney, spinal 1456197_x_at Ajap1 protein 1 4 cord 0.02 0.01 2.45 1424939_at Mm.73091 Asz1 repeat, SAM and basic 4 bladder, lung, 0.03 0.02 2.00 leucine zipper domain containing 1 ovary, testis Mm.59156 brain, eye, sympathetic 1435957_at B830032F12 hypothetical protein B830032F12 4 ganglion, 0.30 0.12 2.43 thymus 1458104_a_at Mm.347681 BC038167 cDNA sequence BC038167 4 brain, eye, lung, 0.08 0.02 3.87 thymus Mm.43133 brain-specific angiogenesis brain,eye, lung, 1455363_at Bai1 inhibitor 1 4 spinal cord 0.05 0.02 2.04 Mm.504 bone, 1422084_at Bmx 4 nasopharynx, 0.09 0.03 3.24 BMX non-receptor tyrosine kinase spleen, thymus Mm.36666 CEA-related cell adhesion extraembr 1439458_x_at Ceacam11 molecule 11 4 tissue, stomach, 0.07 0.03 2.45 testis, uterus Mm.36666 CEA-related cell adhesion 1448197_at Ceacam11 molecule 11 0.02 0.01 2.00 Mm.125647 brain, kidney, liver, mammary 1444626_at D930001B02 hypothetical protein D930001B02 4 gland 0.02 0.01 2.00 Mm.29178 extraembr tissue, EF-hand domain (C-terminal) pancreas, skin, 1453159_at Efhc1 containing 1 4 testis 0.04 0.01 2.83 1449077_at Mm.423023 Eraf erythroid associated factor joint, liver, LN, 0.59 0.29 2.06 4 spleen Mm.188108 Gm1574 / gene model 1574, (NCBI) / similar brain, joint, 1446591_at LOC100045399 to Gene model 1574, (NCBI) 4 prostate, thymus 0.02 0.01 2.45 Mm.100304 intestine, skin, 1458367_at Gm94 gene model 94, (NCBI) 4 stomach, tongue 0.64 0.25 2.60 Mm.70979 brain, joint, mammary gland, 1442116_at Gpr176 -coupled receptor 176 4 spleen 0.10 0.04 2.49 Mm.215 heart, intestine, kidney, 1451660_a_at Hoxb6 homeo box B6 4 mammary gland 0.03 0.01 2.83 Mm.5007 bone,eye, extra embr tissue, 1450501_at Itga2 integrin alpha 2 4 spleen 0.02 0.01 2.45 Mm.246497 immunoglobulin heavy chain (J558 BM, liver,lung, 1421653_a_at Igh family) 4 mammary gland 0.48 0.23 2.11 Mm.133095 extraembr tissue, intestine, 1418609_at Il1f6 interleukin 1 family, member 6 4 stomach, tongue 0.19 0.09 2.05 Mm.440318 liver, salivary gland, skin, 1449387_at Krt33a 33A 4 tongue 0.03 0.01 2.12 Mm.215096 lymphocyte antigen 6 complex, eye, skin, 1422749_at Ly6g6c locus G6C 4 tongue, vagina 0.11 0.05 2.16 Mm.215096 lymphocyte antigen 6 complex, 1449789_x_at Ly6g6c locus G6C 0.08 0.04 2.19 Mm.45207 brain, dorsal root ganglion, 1417217_at Magel2 melanoma antigen, family L, 2 4 eye, spinal cord 0.04 0.02 2.00 Mm.358791 BM, heart, 1419340_at Mov10l1 Moloney leukemia virus 10-like 1 4 ovary, testis 0.02 0.01 2.00 Mm.32566 brain, lung, mammary gland, 1426941_at Muc15 mucin 15 4 skin 0.09 0.04 2.07 Mm.308481 brain, lung, mammary gland, 1457105_at Pkd2l1 polycystic kidney disease 2-like 1 4 testis 0.06 0.02 2.45 Mm.295940 lung, LN, testis, 1440319_at Rbm44 RNA binding motif protein 44 4 thymus 0.02 0.01 2.00 Mm.389950 brain, eye, pituitary gland, 1452892_at Stk33 serine/threonine kinase 33 4 testis 0.08 0.04 2.16 Mm.275336 ovum, lung, 1456033_at Tbx4 T-box 4 4 ovary, skin 0.03 0.01 2.00 Mm.364830 Transcription elongation regulator brain, ovary, 1457133_at Tcerg1l 1-like 4 spleen, testis 0.07 0.03 2.31 Mm.312095 liver, muscle, UDP glucuronosyltransferase 2 pancreas, 1439624_at Ugt2b35 family, polypeptide B35 4 tongue 0.02 0.01 2.00 Mm.442171 brain, eye, kidney, nasopharynx, 1441208_at --- Transcribed locus 5 spleen 0.03 0.01 2.00 Mm.44854 brain, eye, inner ear, pituitary 1455325_at A230057G18Rik RIKEN A230057G18 gene 5 gland, skin 0.06 0.02 2.45 Mm.3407 brain, eye, mammary gland, spinal cord, adenylate cyclase activating sympathetic 1441778_at Adcyap1 polypeptide 1 5 ganglion 0.03 0.01 2.12 Mm.207057 BM, brain, eye, lung, mammary 1457032_at Ak5 adenylate kinase 5 5 gland 0.04 0.01 3.16 Mm.390475 eye, intestine, liver, pituitary 1442187_at Bdkrb2 bradykinin receptor, beta 2 5 gland, skin 0.04 0.02 2.58 Mm.21075 BM, muscle, skin, stomach, 1450633_at Calm4 calmodulin 4 5 tongue 0.96 0.40 2.37 Mm.5195 brain, eye, inner ear, spinal cord, sympathetic 1417746_at Cplx1 complexin 1 5 ganglion 0.05 0.02 2.04 Mm.12896 brain, eye, nasopharynx, spinal cord, 1449236_at Dll3 delta-like 3 5 testis 0.07 0.03 2.12 Mm.59189 brain, epididimis, lung, oviduct, spinal 1436111_at E030011K20Rik RIKEN E030011K20 gene 5 cord 0.05 0.02 2.65 Mm.58847 eye, kidney, ENSMUSG0000 prostate, spinal 1436287_at 0074303 ENSMUSG00000074303 5 cord, spleen 0.03 0.01 3.00 Mm.387697 brain, eye, forkhead-associated (FHA) mammary gland, 1439190_at Fhad1 phosphopeptide binding domain 1 5 pancreas, testis 0.27 0.10 2.69 Mm.35288 intestine, joint, lung, mammary gland, pituitary 1439489_at Gpr120 G protein-coupled receptor 120 5 gland 0.04 0.02 2.24 Mm.59313 eye, intestine, joint, lung, 1431693_a_at Il17b interleukin 17B 5 mammary gland 0.08 0.03 2.29 Mm.292992 brain, eye, skin, spinal cord, 1433923_at Krt77 keratin 77 5 thymus 0.43 0.15 2.81 Mm.302695 / LN, AW550321 nasopharynx, LOC245350 / similar to Ubiquitin-conjugating pituitary gland, 1460600_at LOC634012 enzyme E2Q (putative) 2 5 skin, testis 0.02 0.01 2.00 Mm.255348 brain, dorsal root ganglion, LOC675405 / sodium leak channel, non- eye, spinal cord, 1448083_at Nalcn selective 5 testis 0.02 0.01 2.45 Mm.54174 NLR family, pyrin domain blood, bone, LN, 1425412_at Nlrp3 containing 3 5 skin, spleen 0.04 0.02 2.24 Mm.4777 liver, lung, LN, mammary gland, 1451054_at Orm1 orosomucoid 1 5 muscle 0.36 0.18 2.03 Mm.442446 brain, kidney, mammary gland, 1441102_at Prlr prolactin receptor 5 ovary, thyroid 0.02 0.01 2.00 Mm.353438 blood, bone, BM, eye, LN, 1440300_at --- Transcribed locus 6 thymus 0.04 0.02 2.24 1440608_at Mm.183314 --- RIKEN clone:4732488M12 6 0.03 0.01 3.00 1455961_at Mm.392964 --- Transcribed locus 8 0.04 0.01 3.87 Mm.28440 / 1422324_a_at NM_008970 ------0.40 0.15 2.61 1427820_at Mm.466733 --- clone IMAGE:3983821 0.52 0.18 2.82 1436659_at Mm.443080 --- RIKEN clone:6430555I10 0.12 0.05 2.19 Mm.240299 / 1456753_at AW209075 ------0.05 0.02 2.24 1429072_at Mm.28854 1110001D15Rik RIKEN 1110001D15 gene 9 0.07 0.02 3.03 1428994_s_at Mm.27791 1110017I16Rik RIKEN 1110017I16 gene 0.16 0.07 2.24 1447228_at Mm.386861 1110051M20Rik RIKEN 1110051M20 gene 0.04 0.02 2.45 1419264_at Mm.86472 1200014M14Rik RIKEN 1200014M14 gene 0.05 0.02 2.45 1424722_at Mm.18802 1300017J02Rik RIKEN 1300017J02 gene 0.15 0.07 2.18 1433695_at Mm.425666 1500041B16Rik RIKEN 1500041B16 gene 0.04 0.02 2.24 1428812_at Mm.141830 1700040L02Rik RIKEN 1700040L02 gene 7 0.03 0.01 2.45 1460254_at Mm.45063 1810049H13Rik RIKEN 1810049H13 gene 0.04 0.01 2.83 1453368_at Mm.274890 2310003H01Rik RIKEN 2310003H01 gene 0.03 0.01 2.83 1431712_a_at Mm.29831 2310022A10Rik RIKEN 2310022A10 gene 0.04 0.02 2.31 1452201_at Mm.46647 2310047B19Rik RIKEN 2310047B19 gene 0.04 0.02 2.58 1442077_at Mm.443438 2310076G05Rik RIKEN 2310076G05 gene 8 0.10 0.04 2.56 1453919_at Mm.472489 2610028H24Rik RIKEN 2610028H24 gene 8 0.03 0.01 2.83 1428897_at Mm.87238 2610029I01Rik RIKEN 2610029I01 gene 0.07 0.03 2.02 1429946_at Mm.26579 2610301F02Rik RIKEN 2610301F02 gene 0.05 0.02 2.24 1427397_at Mm.218697 2810046L04Rik RIKEN 2810046L04 gene 0.04 0.01 2.74 1455292_x_at Mm.440811 2810487A22Rik RIKEN 2810487A22 gene 0.05 0.02 2.83 1438122_at Mm.440428 2900006K08Rik RIKEN 2900006K08 gene 7 0.03 0.01 2.12 1438209_at Mm.386816 4632404H12Rik RIKEN 4632404H12 gene 0.03 0.01 2.24 1429249_at Mm.72187 4833424O15Rik RIKEN 4833424O15 gene 7 0.04 0.01 4.47 1451653_a_at Mm.252406 4930430E16Rik RIKEN 4930430E16 gene 0.03 0.02 2.00 1437935_at Mm.335329 4930486G11Rik RIKEN 4930486G11 gene 10 0.05 0.02 2.24 1434978_at Mm.125857 4933403F05Rik RIKEN 4933403F05 gene 0.04 0.02 2.24 1428960_at Mm.27658 4933434I06Rik RIKEN 4933434I06 gene 7 0.05 0.02 2.12 1426320_at Mm.443325 4933437K13Rik RIKEN 4933437K13 gene 0.03 0.01 2.45 1453144_at Mm.247625 4933439C20Rik RIKEN 4933439C20 gene 0.06 0.02 2.31 1442113_at Mm.316890 5330417C22Rik RIKEN 5330417C22 gene 0.06 0.02 2.42 1456070_at Mm.431266 5430405N12Rik RIKEN 5430405N12 gene 0.08 0.04 2.05 1444738_at Mm.130260 5730419I09Rik RIKEN 5730419I09 gene 0.04 0.02 2.31 1430346_at Mm.441986 5730507A09Rik RIKEN 5730507A09 gene 7 0.03 0.01 2.45 1437881_at Mm.442162 6330416L07Rik RIKEN 6330416L07 gene 0.02 0.01 2.00 1423072_at Mm.273536 6720475J19Rik RIKEN 6720475J19 gene 7 0.35 0.17 2.07 1456277_at Mm.400470 7530414M10Rik RIKEN 7530414M10 gene 0.03 0.02 2.00 1455645_at Mm.147208 8030451F13Rik RIKEN 8030451F13 gene 0.04 0.01 4.47 1442769_at Mm.147208 8030451F13Rik RIKEN 8030451F13 gene 0.07 0.02 3.35 1444341_at Mm.147208 8030451F13Rik RIKEN 8030451F13 gene 0.06 0.02 2.58 1435853_at Mm.226708 9030605E09Rik RIKEN 9030605E09 gene 0.03 0.01 2.12 1454662_at Mm.12654 A230106M15Rik RIKEN A230106M15 gene 0.04 0.02 2.24 1455859_at Mm.319007 A330021E22Rik RIKEN A330021E22 gene 0.03 0.01 2.12 1440927_x_at Mm.17957 A330102K04Rik RIKEN A330102K04 gene 7 0.07 0.03 2.12 Mm.20845 ATP-binding cassette, sub-family 1435684_at Abcc5 C (CFTR/MRP), member 5 0.05 0.02 2.04 1435441_at Mm.254446 Ablim2 -binding LIM protein 2 0.04 0.01 3.16 Mm.81793 acetyl-Coenzyme A carboxylase Acacb / beta / similar to acetyl-Coenzyme 1427052_at LOC100047358 A carboxylase beta 0.28 0.08 3.29 1427735_a_at Mm.214950 Acta1 actin, alpha 1, skeletal muscle 0.07 0.03 2.12 Mm.686 Actc1 / actin, alpha, cardiac / similar to 1415927_at LOC100048431 alpha-actin (AA 27-375) 0.11 0.04 2.87 Mm.425794 adenosine deaminase, RNA- 1458112_at Adarb2 specific, B2 7 0.02 0.01 2.00 1421959_s_at Mm.71996 Adcy3 adenylate cyclase 3 0.04 0.02 2.00 1418554_at Mm.2857 Admr adrenomedullin receptor 0.03 0.01 2.12 1427561_a_at Mm.348786 Afm afamin 8 0.07 0.03 2.48 1433466_at Mm.284102 AI467606 AI467606 0.05 0.02 2.05 Mm.243679 AI661708 / AI661708 / coiled-coil domain 1458644_at Ccdc62 containing 62 9 0.03 0.02 2.00 1435940_at Mm.393242 AI836758 /Dclk1 AI836758 0.10 0.03 2.83 1438007_at Mm.51939 AI851790 AI851790 9 0.06 0.03 2.11 1439341_at Mm.261535 AK220484 cDNA sequence AK220484 0.11 0.04 2.71 1442703_at Mm.261535 AK220484 cDNA sequence AK220484 0.05 0.02 2.24 Mm.46044 A kinase (PRKA) anchor protein 1447913_x_at Akap9 (yotiao) 9 0.03 0.01 2.00 1441962_at Mm.41072 Alox5 arachidonate 5-lipoxygenase 0.16 0.06 2.73 Mm.19844 arachidonate 5-lipoxygenase 1452016_at Alox5ap activating protein 0.21 0.09 2.39 1427044_a_at Mm.101650 Amph amphiphysin 0.14 0.06 2.24 1421002_at Mm.208919 Angptl2 angiopoietin-like 2 0.13 0.03 3.78 1450085_at Mm.208919 Angptl2 angiopoietin-like 2 0.07 0.03 2.31 1455090_at Mm.208919 Angptl2 angiopoietin-like 2 0.23 0.11 2.06 1436998_at Mm.145208 Ankrd43 ankyrin repeat domain 43 8 0.02 0.01 2.00 Mm.272772 AN1, ubiquitin-like, homolog 1429642_at Anubl1 (Xenopus laevis) 0.03 0.02 2.00 1442288_at Mm.265347 Anxa6 Annexin A6 0.05 0.02 2.65 1419215_at Mm.244525 Aox4 aldehyde oxidase 4 9 0.11 0.04 2.37 Mm.426783 adaptor-related protein complex 1, 1460036_at Ap1s2 sigma 2 subunit 0.24 0.11 2.13 1421789_s_at Mm.221298 Arf3 ADP-ribosylation factor 3 0.04 0.01 2.74 Mm.440770 / actin related protein 2/3 complex, 1441190_at AV381444 Arpc5l subunit 5-like 7 0.03 0.01 2.12 Mm.136217 achaete-scute complex homolog- 1450164_at Ascl1 like 1 7 0.41 0.18 2.30 Mm.332252 ATG9 autophagy related 9 1434092_at Atg9b homolog B (S. cerevisiae) 0.04 0.02 2.31 Mm.6306 ATPase, Ca++ transporting, 1421129_a_at Atp2a3 ubiquitous 0.24 0.09 2.73 Mm.6306 ATPase, Ca++ transporting, 1450124_a_at Atp2a3 ubiquitous 0.05 0.02 2.74 Mm.321755 ATPase, Ca++ transporting, 1420403_at Atp2b2 plasma membrane 2 9 0.04 0.01 2.83 Mm.12677 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma 1438809_at Atp5c1 polypeptide 1 0.03 0.01 2.12 1419148_at Mm.10739 Avil advillin 0.50 0.12 4.06 1433434_at Mm.208855 AW551984 AW551984 0.10 0.03 3.32 1444236_at Mm.454943 AW552393 AW552393 7 0.03 0.01 2.00 1440934_at Mm.391837 AW742931 AW742931 8 0.02 0.01 2.45 Mm.398181 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1450913_at B4galt6 6 0.03 0.01 2.45 1444119_at Mm.260362 B930006L02Rik RIKEN B930006L02 gene 0.03 0.02 2.00 1424814_a_at Mm.430722 Bcl2l14 Bcl2-like 14 ( facilitator) 0.25 0.12 2.02 1423315_at Mm.7660 Bbc3 Bcl-2 binding component 3 0.15 0.05 2.78 Mm.200714 Bardet-Biedl syndrome 4 homolog 1434460_at Bbs4 (human) 0.04 0.01 2.74 1426734_at Mm.28244 BC022623 cDNA sequence BC022623 0.25 0.12 2.06 1424232_a_at Mm.275341 BC025546 cDNA sequence BC025546 0.03 0.01 2.45 1441991_at Mm.438786 BC039632 cDNA sequence BC039632 0.03 0.02 2.00 1439975_at Mm.99790 BC062109 cDNA sequence BC062109 10 0.08 0.04 2.27 1444632_at Mm.172429 BC064078 cDNA sequence BC064078 8 0.14 0.07 2.04 Mm.240850 breast carcinoma amplified 1428792_at Bcas1 sequence 1 0.06 0.02 2.45 1436098_at Mm.250719 Bche butyrylcholinesterase 0.28 0.13 2.20 1417388_at Mm.94160 Bex2 brain expressed X-linked 2 0.10 0.05 2.08 1421103_at Mm.281490 Bmp2k BMP2 inducible kinase 0.14 0.06 2.35 1448119_at Mm.282863 Bpgm 2,3-bisphosphoglycerate mutase 0.07 0.03 2.14 1416886_at Mm.287982 C1d nuclear DNA binding protein 0.03 0.01 2.12 Mm.258993 C1q and tumor necrosis factor 1417050_at C1qtnf4 related protein 4 9 0.03 0.02 2.00 1434645_at Mm.101504 C530008M17Rik RIKEN C530008M17 gene 0.09 0.04 2.27 1443668_x_at Mm.21144 C79407 C79407 0.02 0.01 2.00 Mm.260881 Ca<2+>dependent activator 1448955_s_at Cadps protein for secretion 1.44 0.69 2.09 1425814_a_at Mm.75467 Calcrl calcitonin receptor-like 0.20 0.09 2.20 1418608_at Mm.20079 Calml3 calmodulin-like 3 0.38 0.19 2.02 1447803_x_at Mm.18626 Capg Capping protein (actin filament), 0.07 0.02 2.83 -like 1443824_s_at Mm.129265 Car7 carbonic anhydrase 7 8 0.12 0.06 2.07 1437592_x_at Mm.45686 Ccdc101 coiled-coil domain containing 101 0.08 0.03 2.29 Mm.458369 brain, eye, lung, mammary gland, 1454222_a_at Ccdc13 coiled-coil domain containing 13 6 skin, testis 0.03 0.02 2.00 1430303_at Mm.296971 Ccdc41 coiled-coil domain containing 41 0.05 0.02 2.16 1417420_at Mm.273049 Ccnd1 D1 0.32 0.15 2.12 1436346_at Mm.32955 Cd109 CD109 antigen 0.04 0.02 2.12 Mm.196638 CDC23 (cell division cycle 23, 1443087_at Cdc23 yeast, homolog) 0.02 0.01 2.00 1418815_at Mm.257437 Cdh2 cadherin 2 0.16 0.07 2.20 1455365_at Mm.441131 Cdh8 cadherin 8 7 0.02 0.01 2.45 Mm.168789 cyclin-dependent kinase inhibitor 1417649_at Cdkn1c 1C (P57) 0.82 0.40 2.07 1442277_at Mm.225505 Chka choline kinase alpha 0.26 0.12 2.09 Mm.240607 cholinergic receptor, muscarinic 1, 1439611_at Chrm1 CNS 9 0.03 0.01 2.45 Mm.4583 cholinergic receptor, nicotinic, 1418852_at Chrna1 alpha polypeptide 1 (muscle) 9 0.04 0.02 2.58 1429283_at Mm.269993 Cisd2 CDGSH iron sulfur domain 2 0.05 0.02 2.19 Mm.454553 chloride channel calcium activated 1417852_x_at Clca1 1 0.40 0.12 3.32 Mm.454553 chloride channel calcium activated 1417853_at Clca1 1 0.13 0.03 4.47 Mm.454553 chloride channel calcium activated 1460259_s_at Clca1 / Clca2 1 / 2 1.75 0.39 4.44 Mm.20897 chloride channel calcium activated 1419463_at Clca2 2 10 1.16 0.28 4.13 Mm.20897 chloride channel calcium activated 1437578_at Clca2 2 0.11 0.03 3.87 Mm.30700 C-type lectin domain family 1, 1421182_at Clec1b member b 9 0.06 0.03 2.00 1429166_s_at Mm.244078 Clmn calmin 0.11 0.03 3.53 Mm.8396 cytidine monophospho-N- 1428043_a_at Cmah acetylneuraminic acid hydroxylase 0.05 0.02 2.50 1456380_x_at Mm.275555 Cnn3 calponin 3, acidic 1.66 0.45 3.66 1428571_at Mm.154662 Col9a1 procollagen, type IX, alpha 1 0.16 0.07 2.20 1449694_s_at Mm.291716 Commd5 COMM domain containing 5 0.03 0.02 2.00 1418771_a_at Mm.24242 Cpb2 carboxypeptidase B2 (plasma) 8 0.05 0.02 2.74 1447392_s_at Mm.276736 Cpd carboxypeptidase D 7 0.04 0.02 2.58 Mm.392985 cleavage and polyadenylation 1431089_at Cpsf2 specific factor 2 7 0.03 0.02 2.00 Mm.28767 C-reactive protein, pentraxin- 1421946_at Crp related 8 0.23 0.10 2.30 1452936_at Mm.313558 Crtac1 cartilage acidic protein 1 7 0.03 0.01 2.00 1421449_at Mm.436988 Csmd1 CUB and Sushi multiple domains 1 7 0.02 0.01 2.00 Mm.66222 coxsackievirus and adenovirus 1452391_at Cxadr receptor 0.07 0.03 2.12 Mm.102312 cytochrome P450, family 2, 1449565_at Cyp2g1 subfamily g, polypeptide 1 7 0.21 0.07 3.20 1436736_x_at Mm.407415 D0H4S114 DNA segment, human D4S114 0.64 0.31 2.05 1450839_at Mm.407415 D0H4S114 DNA segment, human D4S114 1.10 0.52 2.10 Mm.440198 / 1457054_a_at BE991737 D130020L05Rik RIKEN D130020L05 gene 8 0.05 0.02 2.24 Mm.252695 DNA segment, Chr 2, ERATO Doi 1442280_at D2Ertd750e 750, expressed 0.03 0.01 2.12 1436350_at Mm.330351 D430039N05Rik RIKEN D430039N05 gene 9 0.03 0.01 2.00 Mm.384483 DNA segment, Chr 5, ERATO Doi 1446193_at D5Ertd579e 579, expressed 0.02 0.01 2.00 Mm.133704 DNA segment, Chr 7, ERATO Doi 1455087_at D7Ertd715e 715, expressed 0.05 0.02 2.65 1460000_at Mm.458508 D830007B15Rik RIKEN D830007B15 gene 0.04 0.02 2.24 Mm.393242 / 1446190_at BB269897 Dclk1 doublecortin-like kinase 1 0.08 0.02 3.80 Mm.393242 / 1450863_a_at BB269897 Dclk1 doublecortin-like kinase 1 0.15 0.05 2.71 1436532_at Mm.26361 Dclk3 doublecortin-like kinase 3 8 0.09 0.04 2.24 1418028_at Mm.458009 Dct dopachrome tautomerase 10 0.03 0.01 2.45 1418141_at Mm.12871 Dcx doublecortin 10 0.03 0.01 3.00 Mm.234247 dimethylarginine 1454995_at Ddah1 dimethylaminohydrolase 1 0.11 0.03 3.61 1428702_at Mm.307515 Ddx28 DEAD (Asp-Glu-Ala-Asp) box 0.04 0.01 2.74 polypeptide 28 Mm.440021 DENN/MADD domain containing 1433500_at Dennd2a 2A 0.05 0.02 2.24 Mm.296385 DEAH (Asp-Glu-Ala-His) box 1443493_at Dhx37 polypeptide 37 9 0.02 0.01 2.00 1435207_at Mm.82598 Dixdc1 DIX domain containing 1 0.11 0.05 2.01 1437927_at Mm.257035 Dlg2 discs, large homolog 2 0.13 0.05 2.37 1457401_at Mm.459279 Dnahc9 , axonemal, heavy chain 9 7 0.18 0.08 2.27 Mm.292560 delta/notch-like EGF-related 1456379_x_at Dner receptor 0.02 0.01 2.00 1425747_at Mm.258155 Dock5 dedicator of cytokinesis 5 0.03 0.01 3.00 Mm.136736 endothelial differentiation, sphingolipid G-protein-coupled 1460661_at Edg3 receptor, 3 0.09 0.04 2.12 1449548_at Mm.209813 Efnb2 ephrin B2 0.06 0.03 2.09 Mm.206404 eukaryotic initiation factor 3, subunit E interacting 1437948_x_at Eif3eip protein 0.03 0.01 2.00 Mm.227183 eukaryotic translation initiation 1421986_at Eif4e2 factor 4E member 2 0.04 0.01 3.87 1426542_at Mm.41423 Endod1 endonuclease domain containing 1 0.05 0.02 2.24 Mm.10211 ectonucleoside triphosphate 1417383_at Entpd5 diphosphohydrolase 5 0.05 0.02 2.16 Mm.200692 eomesodermin homolog (Xenopus 1435172_at Eomes laevis) 7 0.06 0.03 2.09 1445439_at Mm.210863 Epb4.9 erythrocyte protein band 4.9 0.03 0.02 2.00 1441344_at Mm.279865 Erlin1 ER lipid raft associated 1 0.03 0.01 2.45 1418026_at Mm.283046 Exo1 exonuclease 1 0.03 0.01 2.45 Mm.23122 Fanconi anemia, complementation 1420960_at Fancg group G 0.04 0.02 2.12 Mm.256131 FYVE, RhoGEF and PH domain 1425037_at Fgd4 containing 4 0.07 0.03 2.02 1451693_a_at Mm.7996 Fgf12 fibroblast growth factor 12 9 0.03 0.01 2.12 Mm.330620 Fmn2 / 1450063_at LOC100044570 formin 2 0.08 0.04 2.09 1437324_x_at Mm.287146 Fmod fibromodulin 0.03 0.01 2.00 Mm.244233 fibronectin type III domain 1444367_at Fndc7 containing 7 7 0.06 0.02 3.16 Mm.244233 fibronectin type III domain 1445599_at Fndc7 containing 7 0.06 0.02 2.42 Mm.244233 fibronectin type III domain 1448055_at Fndc7 containing 7 0.10 0.05 2.12 Mm.244233 fibronectin type III domain 1445930_at Fndc7 containing 7 0.07 0.03 2.12 Mm.21158 FK506 binding protein 12- 1436267_a_at Frap1 rapamycin associated protein 1 0.03 0.01 2.45 Mm.24783 FERM and PDZ domain containing 1435189_at Frmpd1 1 0.04 0.01 2.74 1436800_at Mm.379337 Fstl5 follistatin-like 5 10 0.04 0.02 2.00 Mm.278922 far upstream element (FUSE) 1437544_at Fubp1 binding protein 1 0.03 0.01 3.00 Mm.208287 FXYD domain-containing ion 1417343_at Fxyd6 transport regulator 6 0.08 0.02 4.00 Mm.439668 gamma-aminobutyric acid (GABA- 1436889_at Gabra1 A) receptor, subunit alpha 1 7 0.03 0.01 2.12 Mm.156452 GTPase activating protein and 1444066_at Gapvd1 VPS9 domains 1 0.05 0.02 2.74 1429147_at Mm.386823 Gas2 growth arrest specific 2 0.02 0.01 2.00 1415843_at Mm.289516 Gbl G protein beta subunit-like 0.03 0.02 2.00 Mm.102080 ganglioside-induced differentiation-associated protein 1455443_at Gdap1l1 1-like 1 10 0.04 0.02 2.24 Mm.32619 glial cell line derived neurotrophic 1423007_a_at Gfra2 factor family receptor alpha 2 0.04 0.01 3.87 Mm.32619 glial cell line derived neurotrophic 1433716_x_at Gfra2 factor family receptor alpha 2 0.19 0.03 6.07 Mm.390369 gap junction membrane channel 1449094_at Gja7 protein alpha 7 0.03 0.01 2.45 1447475_at Mm.426078 Gm967 gene model 967, (NCBI) 0.02 0.01 2.45 Mm.32595 guanine nucleotide binding 1426517_at Gnaz protein, alpha z subunit 8 0.03 0.01 2.45 Mm.68889 guanine nucleotide binding 12.8 1449159_at Gnb3 protein, beta 3 8 0.18 0.01 5 Mm.230169 glutamate oxaloacetate 1430397_at Got2 transaminase 2, mitochondrial 0.03 0.01 2.00 Mm.4920 glutamate receptor, ionotropic, 1448972_at Gria1 AMPA1 (alpha 1) 8 0.02 0.01 2.00 1455721_at Mm.467706 Gspt2 G1 to S phase transition 2 0.02 0.01 2.45 Mm.289645 GTL2, imprinted maternally 1452183_a_at Gtl2 expressed untranslated mRNA 0.04 0.02 2.24 1426363_x_at Mm.272870 H2afy2 H2A histone family, member Y2 0.11 0.05 2.16 Mm.272870 H2A histone family, member Y3 / 1421612_a_at H2afy2 / H2afy3 H2A histone family, member Y2 0.17 0.08 2.03 1437664_at Mm.458299 Hoxd3 homeo box D3 cord 0.03 0.02 2.00 1425379_at Mm.267078 Hgf hepatocyte growth factor 9 0.05 0.02 2.04 1426282_at Mm.283138 Hnt neurotrimin 7 0.03 0.01 2.00 1426283_at Mm.283138 Hnt neurotrimin 0.03 0.01 2.12 1448881_at Mm.26730 Hp haptoglobin 0.15 0.07 2.12 1417095_a_at Mm.89341 Hspa14 heat shock protein 14 0.04 0.01 3.00 1438251_x_at Mm.30156 Htra1 HtrA serine peptidase 1 0.62 0.23 2.66 1437273_at Mm.334452 Htra4 HtrA serine peptidase 4 7 0.26 0.08 3.07 Mm.27372 HECT, UBA and WWE domain 1443183_at Huwe1 containing 1 0.02 0.01 2.45 1451913_a_at Mm.116721 Hyou1 hypoxia up-regulated 1 0.05 0.02 2.83 1417484_at Mm.4987 Ibsp integrin binding sialoprotein 7 0.02 0.01 2.45 1425895_a_at Mm.444 Id1 inhibitor of DNA binding 1 0.33 0.15 2.23 1419066_at Mm.295464 Ier5l immediate early response 5-like 9 0.05 0.02 2.65 Mm.253664 bladder, mammary gland, lung, skin, 1421628_at Il18r1 interleukin 18 receptor 1 6 spleen, thymus 0.60 0.25 2.38 Mm.64065 inhibitor of growth family, member 1431134_at Ing5 5 0.02 0.01 2.00 1460609_at Mm.246713 Ints8 Integrator complex subunit 8 0.03 0.01 3.46 Mm.146194 interleukin-1 receptor-associated 1435040_at Irak3 kinase 3 0.05 0.02 2.04 1421997_s_at Mm.57035 Itga3 integrin alpha 3 0.19 0.09 2.04 1455257_at Mm.392070 Itgb3 integrin beta 3 0.04 0.02 2.24 Mm.34819 inter alpha-trypsin inhibitor, heavy 1431808_a_at Itih4 chain 4 10 0.09 0.04 2.11 1436066_at Mm.441119 Kalrn kalirin, RhoGEF kinase 0.06 0.02 3.24 Mm.222831 potassium voltage-gated channel, shaker-related subfamily, member 1417680_at Kcna5 5 9 0.02 0.01 2.00 Mm.62535 potassium voltage-gated channel, shaker-related, subfamily, member 1421568_at Kcna6 6 7 0.02 0.01 2.00 Mm.336519 / Potassium voltage-gated channel, 1457587_at BB196645 Kcnq5 subfamily Q, member 5 10 0.02 0.01 2.00 1447236_at Mm.41379 Kif21a family member 21A 0.02 0.01 2.45 1426493_a_at Mm.378950 Kifc2 kinesin family member C2 0.05 0.02 2.16 1452514_a_at Mm.247073 Kit kit oncogene 0.39 0.19 2.08 1455521_at Mm.396499 Klf12 Kruppel-like factor 12 0.04 0.01 3.00 1439847_s_at Mm.396499 Klf12 Kruppel-like factor 12 0.13 0.04 3.50 1428221_at Mm.283194 Klhdc8b kelch domain containing 8B 0.06 0.02 2.96 1422481_at Mm.183137 Krt1 9 0.25 0.11 2.22 1452166_a_at Mm.22662 Krt10 1.52 0.63 2.40 1457354_at Mm.133193 Krt222 keratin 222 7 0.07 0.03 2.45 Mm.105278 kynureninase (L-kynurenine 1451903_at Kynu hydrolase) 7 0.03 0.02 2.00 1424807_at Mm.258065 Lama4 laminin, alpha 4 0.09 0.04 2.31 1424808_at Mm.258065 Lama4 laminin, alpha 4 0.03 0.01 3.46 Mm.374778 LIM and calponin homology 1435321_at Limch1 domains 1 0.38 0.17 2.21 1437752_at Mm.302567 Lin28 lin-28 homolog (C. elegans) 8 0.02 0.01 2.45 1419560_at Mm.390187 Lipc lipase, hepatic 0.11 0.05 2.24 1456619_at Mm.33192 Liph lipase, member H 0.03 0.02 2.00 1433812_at Mm.316728 Lix1l Lix1-like 0.05 0.02 2.29 Mm.41572 / 1442371_at BM898643 Lmbr1 limb region 1 0.03 0.01 2.00 1421063_s_at Mm.274995 Snrpn small nuclear ribonucleoprotein N 0.14 0.06 2.23 1439568_at Mm.428062 LOC100045413 similar to Greb1 protein 10 0.03 0.01 2.12 1454729_at Mm.384704 Tmem108 transmembrane protein 108 0.08 0.03 2.51 1449264_at Mm.379376 Syt11 synaptotagmin XI 0.04 0.02 2.58 1437479_x_at Mm.219139 Tbx3 T-box 3 0.03 0.01 2.12 1452436_at Mm.116714 Loxl2 lysyl oxidase-like 2 0.06 0.03 2.09 Mm.370185 / similar to Guanine nucleotide- BF302166 binding protein alpha-12 subunit 1450097_s_at LOC100048021 (G alpha-12) 0.08 0.03 2.24 Mm.389969 prolylcarboxypeptidase 1452191_at Prcp (angiotensinase C) 0.18 0.09 2.01 Mm.393827 / similar to Beta-1,4- 1435758_at BI685536 LOC675709 galactosyltransferase 6 8 0.11 0.03 3.16 Mm.277518 monocyte to macrophage 1435645_at Mmd differentiation-associated 0.05 0.02 2.83 Mm.843 lymphoid-restricted membrane 1448409_at Lrmp protein 0.19 0.07 2.74 1429679_at Mm.439963 Lrrc17 leucine rich repeat containing 17 0.07 0.02 4.24 Mm.292568 leucine rich repeat transmembrane 1455883_a_at Lrrtm1 neuronal 1 0.03 0.01 2.45 1431569_a_at Mm.32727 Lypd1 Ly6/Plaur domain containing 1 7 0.06 0.01 4.47 1432431_s_at Mm.229466 Macrod2 MACRO domain containing 2 0.16 0.06 2.54 Mm.132613 mucosa associated lymphoid tissue lymphoma translocation 1445068_at Malt1 gene 1 0.36 0.17 2.12 1451203_at Mm.404074 Mb myoglobin 0.02 0.01 2.45 1443597_at Mm.17616 Med14 mediator complex subunit 14 0.03 0.01 2.45 1458015_at Mm.127721 Megf11 multiple EGF-like-domains 11 8 0.02 0.01 2.45 1453165_at Mm.139146 Mettl4 methyltransferase like 4 0.05 0.02 2.24 Mm.288721 mesoderm induction early response 1 homolog (Xenopus 1453760_at Mier1 laevis 0.04 0.02 2.00 Mm.48712 monocyte to macrophage 1438654_x_at Mmd2 differentiation-associated 2 10 0.03 0.01 3.00 1448291_at Mm.4406 Mmp9 matrix metallopeptidase 9 0.30 0.14 2.20 Mm.28579 mitochondrial 1419362_at Mrpl35 L35 0.02 0.01 2.00 1459665_s_at Mm.250023 Mrvi1 MRV integration site 1 0.09 0.03 3.35 1421851_at Mm.466781 Mtap1b -associated protein 1 B 0.08 0.04 2.00 1446284_at Mm.215481 Mtss1 metastasis suppressor 1 0.05 0.02 2.50 Mm.250705 , heavy polypeptide 11, 1448962_at Myh11 smooth muscle 0.57 0.19 3.04 1452651_a_at Mm.1000 Myl1 myosin, light polypeptide 1 0.06 0.02 2.58 1422580_at Mm.390355 Myl4 myosin, light polypeptide 4 0.06 0.02 2.42 Mm.14526 , phosphorylatable, fast skeletal 1448371_at Mylpf muscle 0.14 0.07 2.01 1435559_at Mm.4040 Myo6 myosin VI 0.04 0.01 3.16 1438175_x_at Mm.272115 Myom2 myomesin 2 10 0.03 0.01 2.00 1435382_at Mm.400253 Ndn necdin 0.10 0.05 2.04 1455792_x_at Mm.400253 Ndn necdin 0.08 0.03 2.29 1423506_a_at Mm.233903 Nnat neuronatin 0.08 0.03 2.83 1456387_at Mm.465450 Nol4 nucleolar protein 4 10 0.22 0.05 4.15 1416473_a_at Mm.209041 Nope neighbor of Punc E11 0.30 0.12 2.49 1416474_at Mm.209041 Nope neighbor of Punc E11 0.35 0.16 2.20 1422130_at Mm.5142 Nptx1 neuronal pentraxin 1 0.07 0.03 2.65 1421253_at Mm.386769 Nrap nebulin-related anchoring protein 7 0.03 0.02 2.00 Mm.46539 Notch-regulated ankyrin repeat 1417986_at Nrarp protein 0.08 0.02 4.58 Mm.208439 neuron-glia-CAM-related cell 1430583_at Nrcam adhesion molecule 0.03 0.01 2.12 Mm.208439 neuron-glia-CAM-related cell 1434709_at Nrcam adhesion molecule 0.10 0.04 2.24 1454691_at Mm.312068 Nrxn1 neurexin I 0.07 0.03 2.45 Mm.3304 neuron specific gene family 1456685_at Nsg2 member 2 0.04 0.02 2.24 1427491_at Mm.195859 Nsun6 NOL1/NOP2/Sun domain family 6 10 0.03 0.01 2.83 1459842_x_at Mm.36718 Nubp2 nucleotide binding protein 2 0.04 0.02 2.24 Mm.103155 bone, conective tissue, eye, ovary, pituitary 1420585_a_at Nxf2 nuclear RNA export factor 2 6 gland, testis 0.02 0.01 2.00 1427535_s_at Mm.236454 Obsl1 obscurin-like 1 0.11 0.05 2.04 Mm.54183 brain, eye, kidney, liver, spinal cord, 1425898_x_at Olfm3 olfactomedin 3 6 embryo 0.05 0.02 2.89 1420543_at Mm.101927 ORF28 open reading frame 28 0.03 0.01 2.12 1445390_at Mm.391419 Pawr PRKC, apoptosis, WT1, regulator 0.03 0.01 2.00 1437722_x_at Mm.272803 Pcbp3 Poly(rC) binding protein 3 0.03 0.01 2.12 1424701_at Mm.128861 Pcdh20 protocadherin 20 7 0.04 0.01 3.87 Mm.390792 phosphodiesterase 1B, Ca2+- 1449420_at Pde1b calmodulin dependent 0.08 0.03 2.24 1444386_at Mm.5145 Pde1c phosphodiesterase 1C 0.11 0.04 2.45 Mm.129840 phosphodiesterase 4D interacting 1460426_at Pde4dip protein (myomegalin) 0.07 0.02 2.89 Mm.129840 phosphodiesterase 4D interacting 1417626_at Pde4dip protein (myomegalin) 0.26 0.13 2.02 1449178_at Mm.282900 Pdlim3 PDZ and LIM domain 3 0.27 0.12 2.24 1443299_at Mm.282900 Pdlim3 PDZ and LIM domain 3 0.06 0.03 2.29 1417356_at Mm.389800 Peg3 paternally expressed 3 0.03 0.01 2.45 Mm.244960 phosphoinositide-3-kinase, 1434980_at Pik3r5 regulatory subunit 5, p101 0.19 0.09 2.17 Mm.246804 paired-like homeodomain 1424797_a_at Pitx2 transcription factor 2 0.02 0.01 2.45 1417553_at Mm.274842 Plac1 placental specific protein 1 7 0.04 0.02 2.12 Mm.332102 pleckstrin homology domain containing, family G (with RhoGef 1452248_at Plekhg5 domain) member 5 0.10 0.03 3.76 1450952_at Mm.34145 Pln phospholamban 6 0.05 0.02 2.45 1460332_at Mm.34145 Pln phospholamban 0.04 0.02 2.24 Mm.897 POU domain, class 2, associating 1416957_at Pou2af1 factor 1 0.15 0.07 2.21 Mm.26134 2 (formerly 2A), regulatory subunit B (PR 52), 1426621_a_at Ppp2r2b beta isoform 0.04 0.01 3.16 Mm.207004 , AMP-activated, 1437539_at Prkaa1 alpha 1 catalytic subunit 0.05 0.02 2.04 Mm.381170 protein kinase, cGMP-dependent, 1449876_at Prkg1 type I 10 0.05 0.02 2.04 Mm.263002 protein kinase, cGMP-dependent, 1435460_at Prkg2 type II 0.06 0.03 2.05 1425681_a_at Mm.180750 Prnd prion protein dublet 0.09 0.05 2.07 Mm.30210 Proteasome (prosome, macropain) 1435316_at Psma6 subunit, alpha type 6 0.02 0.01 2.00 Mm.32215 protein prenyltransferase alpha 1432162_s_at Ptar1 subunit repeat containing 1 0.02 0.01 2.45 Mm.275434 prostaglandin-endoperoxide 1436448_a_at Ptgs1 synthase 1 0.08 0.03 2.93 Mm.258771 protein tyrosine phosphatase, 1436855_at Ptprs receptor type, S 0.03 0.01 3.46 Mm.133593 RAB36, member RAS oncogene 1436471_at Rab36 family 0.03 0.01 2.45 Mm.158705 / Rab9 effector protein with kelch 1433041_at AK018405 Rabepk motifs 0.03 0.01 3.46 Mm.25833 GTPase activating protein 1- 1429196_at Rabgap1l like 0.11 0.05 2.39 1449476_at Mm.140948 Rage renal tumor antigen 10 0.06 0.02 2.96 Mm.274249 Ral GEF with PH domain and SH3 1431391_at Ralgps1 binding motif 1 0.02 0.01 2.45 1456262_at Mm.259197 Rbm5 RNA binding motif protein 5 0.15 0.07 2.12 Mm.28275 RNA binding motif protein, X 1416355_at Rbmx 0.03 0.01 2.12 Mm.252718 Rho-guanine nucleotide exchange 1419458_at Rgnef factor 0.19 0.08 2.23 1417466_at Mm.20954 Rgs5 regulator of G-protein signaling 5 1.56 0.60 2.62 1420940_x_at Mm.20954 Rgs5 regulator of G-protein signaling 5 1.06 0.40 2.67 1420941_at Mm.20954 Rgs5 regulator of G-protein signaling 5 0.91 0.25 3.57 1420942_s_at Mm.20954 Rgs5 regulator of G-protein signaling 5 0.68 0.21 3.15 Mm.100348 regulator of G-protein signalling 7 1436876_at Rgs7bp binding protein 0.03 0.01 2.12 1416126_at Mm.259078 Rpo1-2 RNA polymerase 1-2 0.07 0.03 2.37 1434909_at Mm.300814 Rragd Ras-related GTP binding D 0.37 0.12 3.01 Mm.193274 R-spondin 2 homolog (Xenopus 1455893_at Rspo2 laevis) 10 0.04 0.02 2.24 Mm.200203 RUN and TBC1 domain containing 1447979_at Rutbc2 2 0.06 0.02 2.45 1418782_at Mm.3475 Rxrg retinoid X receptor gamma 8 0.05 0.02 2.45 1434958_at Mm.440703 Sacs sacsin 10 0.06 0.03 2.09 Mm.145599 special AT-rich sequence binding 1427017_at Satb2 protein 2 10 0.06 0.02 3.00 1457689_at Mm.102970 Sbf2 SET binding factor 2 0.02 0.01 2.45 1459898_at Mm.250717 Sbsn suprabasin 0.08 0.04 2.16 Mm.384279 sodium channel, voltage-gated, 1439204_at Scn3a type III, alpha 10 0.03 0.01 2.45 Mm.290083 sodium channel, voltage-gated, 1435767_at Scn3b type III, beta 9 0.10 0.02 6.06 1419975_at Mm.379011 Scp2 Sterol carrier protein 2, liver 0.05 0.02 2.05 Mm.158320 orphan short chain 1430785_at Sdro dehydrogenase/reductase 7 0.06 0.03 2.29 Mm.158320 orphan short chain 1456074_at Sdro dehydrogenase/reductase 0.06 0.03 2.11 Mm.31421 SEC22 vesicle trafficking protein- 1456091_at Sec22c like C (S. cerevisiae) 0.02 0.01 2.45 1417414_at Mm.309707 Sept3 septin 3 0.03 0.02 2.00 1440936_at Mm.5548 Serac1 serine active site containing 1 0.03 0.01 2.45 1423751_at Mm.256422 Sf1 splicing factor 1 0.11 0.05 2.07 1416594_at Mm.281691 Sfrp1 secreted frizzled-related protein 1 0.14 0.06 2.14 Mm.45472 SH3 domain containing ring finger 1456640_at Sh3rf2 2 0.05 0.02 2.16 Mm.74636 solute carrier family 16 (monocarboxylic acid 1434188_at Slc16a12 transporters), member 12 0.03 0.01 2.24 Mm.204834 solute carrier family 1 (glial high affinity ), 1443749_x_at Slc1a3 member 3 0.33 0.12 2.76 Mm.338690 solute carrier family 35, member 1436719_at Slc35f1 F1 10 0.03 0.01 3.00 Mm.441391 solute carrier family 4, sodium bicarbonate transporter-like, 1434867_at Slc4a11 member 11 0.25 0.12 2.06 Mm.253984 solute carrier family 6 (neurotransmitter transporter), 1420503_at Slc6a14 member 14 8 0.07 0.03 2.33 Mm.57040 brain, eye, prostate, uterus, solute carrier family 6 sympathetic (neurotransmitter transporter, ganglion, 1460129_at Slc6a2 noradrenalin), member 2 6 extraembr tissue 0.03 0.02 2.00 Mm.326125 solute carrier family 9 (sodium/hydrogen exchanger), 1437488_at Slc9a9 isoform 9 0.04 0.02 2.24 1458140_at Mm.289739 Slit2 slit homolog 2 0.03 0.01 2.45 1420884_at Mm.29132 Sln sarcolipin 8 0.07 0.03 2.21 Mm.2999 structural maintenance of 1429658_a_at Smc2 2 0.03 0.01 2.00 Mm.173953 structural maintenance of 1422909_at Smc6 chromosomes 6 0.05 0.02 2.16 Mm.234274 SET and MYND domain 1443727_x_at Smyd1 containing 1 10 0.03 0.01 3.46 Mm.27103 Small nucleolar RNA host gene 1447483_s_at Snhg7 (non-protein coding) 7 0.03 0.01 2.45 1441942_x_at Mm.220984 Snupn snurportin 1 0.08 0.03 2.87 Mm.70980 sortilin-related VPS10 domain 1425110_at Sorcs3 containing receptor 3 7 0.07 0.02 2.83 1455562_at Mm.28424 Sox12 SRY-box containing gene 12 0.04 0.02 2.00 1416564_at Mm.42162 Sox7 SRY-box containing gene 7 0.05 0.02 2.24 1417528_at Mm.31701 Spag6 sperm associated antigen 6 7 0.04 0.01 2.74 1430556_at Mm.260737 Spag9 sperm associated antigen 9 0.04 0.02 2.00 Mm.465397 splA/ryanodine receptor domain 1451419_at Spsb4 and SOCS box containing 4 0.03 0.01 2.12 Mm.284688 signal recognition particle receptor 1427570_at Srpr ('docking protein') 0.03 0.01 2.00 1437168_at Mm.156636 Srrp serine-arginine repressor protein 8 0.02 0.01 2.00 1455123_at Mm.234612 St18 suppression of tumorigenicity 18 0.04 0.01 2.74 Mm.263639 signal transducing adaptor molecule (SH3 domain and ITAM 1453338_at Stam2 motif) 2 0.03 0.01 2.12 1423281_at Mm.29580 Stmn2 -like 2 0.06 0.02 2.65 1456883_at Mm.39821 Stox1 storkhead box 1 8 0.15 0.05 2.73 1421990_at Mm.289702 Syt1 synaptotagmin I 8 0.49 0.23 2.10 1431191_a_at Mm.289702 Syt1 synaptotagmin I 0.34 0.17 2.02 Mm.244393 TRAF family member-associated 1441513_at Tank Nf-kappa B activator 0.06 0.03 2.29 1442325_at Mm.301585 Tbc1d24 TBC1 domain family, member 24 0.03 0.01 2.45 1421909_at Mm.252156 Tcf20 transcription factor 20 0.05 0.02 2.16 1434425_at Mm.316671 Tchh trichohyalin 7 0.08 0.03 2.45 1453360_a_at Mm.14485 Tex9 testis expressed gene 9 0.02 0.01 2.45 1416033_at Mm.251890 Tmem109 transmembrane protein 109 0.03 0.02 2.00 1433896_at Mm.200889 Tmem127 transmembrane protein 127 0.03 0.01 2.45 1444883_at Mm.29647 Tmem19 transmembrane protein 19 0.06 0.02 2.45 1422587_at Mm.262328 Tmem45a transmembrane protein 45a 0.32 0.16 2.03 1434307_at Mm.394111 Tmem64 transmembrane protein 64 0.17 0.08 2.09 Mm.137858 transmembrane and tetratricopeptide repeat containing 1439855_at Tmtc1 1 0.02 0.01 2.00 1437915_at Mm.218875 Tom1l2 target of myb1-like 2 (chicken) 0.02 0.01 2.00 Mm.29358 polymerization-promoting 1416713_at Tppp3 protein family member 3 0.27 0.13 2.07 1456089_at Mm.244190 Trim23 tripartite motif protein 23 0.03 0.02 2.00 Mm.211229 Triple functional domain (PTPRF 1457492_at Trio interacting) 0.04 0.02 2.24 Mm.286668 transient receptor potential cation 1418783_at Trpm5 channel, subfamily M, member 5 8 0.10 0.03 3.37 Mm.286668 transient receptor potential cation 1443413_s_at Trpm5 channel, subfamily M, member 5 0.06 0.02 3.24 1416872_at Mm.46701 Tspan6 tetraspanin 6 0.11 0.04 2.57 1427446_s_at Mm.373672 Ttn 0.23 0.11 2.13 Mm.29807 ubiquitin carboxy-terminal 1448260_at Uchl1 hydrolase L1 0.04 0.01 2.83 Mm.4177 uncoupling protein 1 1418197_at Ucp1 (mitochondrial, proton carrier) 0.04 0.01 3.00 1419592_at Mm.24430 Unc5c unc-5 homolog C (C. elegans) 0.05 0.02 2.65 1449522_at Mm.24430 Unc5c unc-5 homolog C (C. elegans) 0.09 0.04 2.31 Mm.20273 ubiquitin related modifier 1 1437227_at Urm1 homolog (S. cerevisiae) 0.03 0.02 2.00 1437118_at Mm.295330 Usp7 ubiquitin specific peptidase 7 0.07 0.03 2.45 Mm.1402 vascular endothelial growth factor 1419417_at Vegfc C 0.06 0.02 2.58 1437257_at Mm.285968 Wdr47 WD repeat domain 47 0.05 0.02 2.65 1434433_x_at Mm.28437 Wdr61 WD repeat domain 61 0.06 0.02 2.96 1434793_at Mm.374877 Wdr78 WD repeat domain 78 0.07 0.02 2.89 Mm.23656 WNK lysine deficient protein 1427196_at Wnk4 kinase 4 0.04 0.01 2.74 Mm.440155 zinc finger, CCHC domain 1425293_a_at Zcchc18 containing 18 0.05 0.02 3.16 Mm.187446 zinc finger protein 184 (Kruppel- 1441997_at Zfp184 like) 9 0.03 0.01 2.12 1457078_at Mm.382935 Zfp473 zinc finger protein 473 8 0.03 0.01 3.00 1435669_at Mm.286232 Zfp532 zinc finger protein 532 0.06 0.02 2.58

Expressed in 1-2 tissues Expressed in 3-4 tissues Expressed in 5 tissues Expressed in more than 5 tissues

FC>4 FC>3

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