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Home , ABI gene family member 3, AEBP2, Aminomethyltransferase, ANKRD13C, ANKRD25, AP1G1

Treatment and Resiliency Exhibit

Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models

Wilkinson et al.

Supplemental Material

1. Supplemental Methods

2. Supplemental References for Tables

3. Supplemental Tables S1 – S24

SUPPLEMENTAL TABLE S1: Demonstrating Increased Repressive DimethylK9/K27-H3 in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S2: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S3: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in the Social Isolation Model (p<0.001)

SUPPLEMENTAL TABLE S4: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in the Social Isolation Model (p<0.001)

SUPPLEMENTAL TABLE S5: Genes Demonstrating Common Altered Repressive DimethylK9/K27-H3 Methylation in the Social Defeat and Social Isolation Models (p<0.001)

SUPPLEMENTAL TABLE S6: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat and Social Isolation Models (p<0.001)

SUPPLEMENTAL TABLE S7: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat and Social Isolation Models (p<0.001)

SUPPLEMENTAL TABLE S8: Genes Demonstrating Increased Phospho-CREB Binding in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S9: Genes Demonstrating Decreased Phospho-CREB Binding in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S10: Genes Demonstrating Increased Phospho-CREB Binding in the Social Isolation Model (p<0.001)

SUPPLEMENTAL TABLE S11: Genes Demonstrating Decreased Phospho-CREB Binding in the Social Isolation Model (p<0.001)

SUPPLEMENTAL TABLE S12: Genes Demonstrating Altered Phospho-CREB Binding in the Social Defeat and Social Isolation Models (p<0.001)

1

SUPPLEMENTAL TABLE S13: Genes Demonstrating Reversal of Decreased Repressive DimethylK9/K27-H3 Methylation by Imipramine in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S14: Genes Demonstrating Reversal of Increased Repressive DimethylK9/K27-H3 Methylation by Imipramine in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S15: Genes Demonstrating Reversal of Decreased Phospho-CREB Binding by Imipramine in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S16: Genes Demonstrating Reversal of Increased Phospho-CREB Binding by Imipramine in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S17: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in Resilient Animals Compared to Susceptible Animals (p<0.001)

SUPPLEMENTAL TABLE S18: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in Resilient Animals Compared to Susceptible Animals (p<0.001)

SUPPLEMENTAL TABLE S19: Genes Demonstrating Increased Phospho-CREB Binding in Resilient Animals Compared to Susceptible Animals(p<0.001)

SUPPLEMENTAL TABLE S20: Genes Demonstrating Decreased Phospho-CREB Binding in Resilient Animals Compared to Susceptible Animals(p<0.001)

SUPPLEMENTAL TABLE S21: Genes Demonstrating Reversal of Decreased Repressive DimethylK9/K27-H3 Methylation by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S22: Genes Demonstrating Reversal of Increased Repressive DimethylK9/K27-H3 Methylation by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S23: Genes Demonstrating Reversal of Decreased Phospho-CREB Binding by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

SUPPLEMENTAL TABLE S24: Genes Demonstrating Reversal of Increased Phospho-CREB Binding by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

2

1. Supplemental Methods

Analyses of ChIP-chip and expression data

Pre-processing and normalization of ChIP-chip data

The log2 ratios of signal intensities between the immunoprecipitated samples and control genomic DNA

(input) were calculated. These ratios were scaled by Tukey’s Bi-weight method (Statistical Algorithms

Description Document, 2002, Affymetrix), such that the values are robust against outliers. The data were then

median-normalized in R software (R Development Core Team) as described previously (Gentleman et al.,

2005). The floor method, which treats all negative values as zero, was used to handle background noises.

Negative values represent background noise where control genomic sample shows the same or more gene

enrichment than immunoprecipitated sample. These genes were not considered as endogenous gene targets of

the chromatin modification or factor under investigation.

Identifying significant alterations from ChIP-chip data

To identify the probes at which methylation is altered after chronic social defeat or social

isolation, we derived a score (calculating the alteration for each probe from the mean; hereafter, alteration

score) for each probe using the following procedures. First, the mean methylation signal for each probe under

each condition was calculated by averaging the normalized log2 ratios of intensities of immunoprecipitated

samples and input across the replicated samples. Second, methylation signal difference between the defeat or

social isolation conditions and its control condition was calculated. Third, a moving average of the methylation

signal difference of three adjacent probes within the region of each gene was calculated to stabilize

the signal, using an algorithm similar to the ChIPOTle algorithm (Buck et al., 2005). The alteration scores that

3 were more than 3.1 standard deviations from the mean were considered as significant, as described in Kim et al.

(2005). False discovery rates (FDR) (Benjamini and Hochberg, 1995; Efron and Tibshirani, 2002) were further calculated using R ClassComparison package, which calculated FDR by fitting a beta-uniform mixture model

(Pounds and Morris, 2003) to a set of p-values. For histone methylation data, the probes with p-values less than

0.001, corresponding to more than 3.1 standard deviation away from the mean, are claimed as significant probes, corresponding to FDR’s less than 0.18 and 0.16 for the defeat and isolation conditions, respectively.

Certain gene promoters displayed both significant increases and decreases in H3 methylation at various

probes along their promoter regions under defeat or isolation conditions. These genes were included in the

Supplemental Tables as both up-regulated and down-regulated to avoid averaging out the information. The

same analysis methods were applied to phospho-CREB ChIP-chip data to identify the probes with binding changes under defeat or isolation conditions.

Promoter plots and genome-wide spatial binding patterns

We used mpeak software (Zheng et al., 2007) to derive the signal peaks and overall spatial pattern of the

locations of dimethylK9/K27-H3 and phospho-CREB binding relative to transcriptional start sites. The empirical densities of the peak location were plotted and compared between defeat (or isolation) condition and control condition. The empirical densities were estimated using R statistical software with all default settings

(adjust=1). In this circumstance, the bandwidth was determined by R density function automatically according

to the number of enrichment probes, identified from the mpeak package. The bandwidths for H3 methylation

and phospho-CREB binding are 271 and 623, respectively, in social defeat. The bandwidths for H3 methylation

and phospho-CREB binding are 315 and 649 respectively, in social isolation.

Heatmaps

4 The heatmaps included in Figs. 1-4 of the manuscript depict the signal strength averaged across probes for each gene. Genes listed in the Tables are those with greater than 1.1 fold change in our published DNA expression arrays (Berton et al., 2006; Krishnan et al., 2007; Wallace et al., 2009). The genes were rearranged using the Spearman hierarchical clustering method (Genespring).

Quality Control

As one measure of quality control, we determined the consistency between biological replicates by calculating the overlap of significantly enriched genes for each replicate. As an example, we show the data for dimethylK9/K27-H3 for group- housed mice below. We observed similar reproducibility for other data, typically with between 70-80% identity between replicates at p values approaching zero (calculated as described above). Furthermore, the Pearson’s correlations between two replicates are about 0.6-0.9. Hierarchical clustering also confirmed that biological replicates clustered together.

H3methylationingrouphousedmice

324 1272 375

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8 3. Supplemental Tables

SUPPLEMENTAL TABLE S1: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat Model (p<0.001)

Accession Number Symbol Name Fold Change NM_053102 15-Sep Selenoprotein 1.52 NM_026152 0610010D20Rik RIKEN cDNA 0610010D20 gene 1.46 NM_025345 0610037P05Rik RIKEN cDNA 0610037P05 gene 1.51 NM_026995 0710008K08Rik RIKEN cDNA 0710008K08 gene 1.45 NM_145955 1110007A13Rik RIKEN cDNA 1110007A13 gene 1.47 NM_026808 1110028A07Rik RIKEN cDNA 1110028A07 gene 1.41 NM_026503 1110058L19Rik RIKEN cDNA 1110058L19 gene 1.51 NM_028055 1500005I02Rik RIKEN cDNA 1500005I02 gene 1.44 NM_030087 1500032D16Rik RIKEN cDNA 1500032D16 gene 1.52 NM_029285 1700001C02Rik RIKEN cDNA 1700001C02 gene 1.53 NM_198637 1700016K19Rik RIKEN cDNA 1700016K19 gene 1.44 NM_025492 1700020L24Rik RIKEN cDNA 1700020L24 gene 1.48 NM_026469 1700025D03Rik RIKEN cDNA 1700025D03 gene 1.55 NM_029335 1700026D08Rik RIKEN cDNA 1700026D08 gene 1.60 NM_028170 1700030K09Rik RIKEN cDNA 1700030K09 gene 1.58 NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene 1.63 NM_026096 1700054O13Rik RIKEN cDNA 1700054O13 gene 1.65 NM_028550 1700074P13Rik RIKEN cDNA 1700074P13 gene 1.43 NM_183103 1700112C13Rik RIKEN cDNA 1700112C13 gene 1.62 NM_026627 1700113O17Rik RIKEN cDNA 1700113O17 gene 1.43 NM_026918 1810010M01Rik RIKEN cDNA 1810010M01 gene 1.60 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 1.55 NM_024249 1810073N04Rik RIKEN cDNA 1810073N04 gene 1.46 NM_001025573 2010107G12Rik RIKEN cDNA 2010107G12 gene 1.47 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 1.58 NM_133829 2210010L05Rik RIKEN cDNA 2210010L05 gene 1.60 NM_197999 2210023G05Rik RIKEN cDNA 2210023G05 gene 1.42 NM_027087 2300006N05Rik RIKEN cDNA 2300006N05 gene 1.42 NM_027087 2300006N05Rik RIKEN cDNA 2300006N05 gene 1.42 NM_027093 2310003L22Rik RIKEN cDNA 2310003L22 gene 1.54 NM_026189 2310005P05Rik RIKEN cDNA 2310005P05 gene 1.55 NM_025864 2310028N02Rik RIKEN cDNA 2310028N02 gene 1.47 NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene 1.68 NM_027344 2310051M13Rik RIKEN cDNA 2310051M13 gene 1.44 NM_025542 2410001C21Rik RIKEN cDNA 2410001C21 gene 1.49 NM_028034 2410004F06Rik RIKEN cDNA 2410004F06 gene 1.51 NM_026630 2410116G06Rik RIKEN cDNA 2410116G06 gene 1.44 NM_027426 2610109H07Rik RIKEN cDNA 2610109H07 gene 1.50 NM_026010 2610209A20Rik RIKEN cDNA 2610209A20 gene 1.64 NM_001025576 2610301F02Rik RIKEN cDNA 2610301F02 gene 1.47 NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene 1.47 NM_025849 3110001D03Rik RIKEN cDNA 3110001D03 gene 1.53 NM_001040397 4631422O05Rik RIKEN cDNA 4631422O05 gene 1.57 NM_172652 4632411B12Rik RIKEN cDNA 4632411B12 gene 1.47 NM_177087 4632412N22Rik RIKEN cDNA 4632412N22 gene 1.55 NM_175497 4732495G21Rik RIKEN cDNA 4732495G21 gene 1.46 NM_133797 4833439L19Rik RIKEN cDNA 4833439L19 gene 1.41 NM_001009544 4921501E09Rik RIKEN cDNA 4921501E09 gene 1.60 NM_029773 4921517N04Rik RIKEN cDNA 4921517N04 gene 1.42 NM_027616 4921528I01Rik RIKEN cDNA 4921528I01 gene 1.52 NM_134041 4930427A07Rik RIKEN cDNA 4930427A07 gene 1.41 NM_001025373 4930432O21Rik RIKEN cDNA 4930432O21 gene 1.68 NM_029141 4930511M11Rik RIKEN cDNA 4930511M11 gene 1.50 NM_207275 4930517K23Rik RIKEN cDNA 4930517K23 gene 1.57 NM_172450 4930539E08Rik RIKEN cDNA 4930539E08 gene 1.45 NM_183111 4930563M21Rik RIKEN cDNA 4930563M21 gene 1.55

9 NM_029232 4930563P21Rik RIKEN cDNA 4930563P21 gene 1.56 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 1.43 NM_025737 4931417E11Rik RIKEN cDNA 4931417E11 gene 1.62 NM_172534 4932411E22Rik RIKEN cDNA 4932411E22 gene 1.42 NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene 1.58 NM_024203 4932442K08Rik RIKEN cDNA 4932442K08 gene 1.41 NM_175368 4933402P03Rik RIKEN cDNA 4933402P03 gene 1.57 NM_001033160 4933407I18Rik RIKEN cDNA 4933407I18 gene 1.50 NM_177880 4933411G11Rik RIKEN cDNA 4933411G11Rik gene 1.52 NM_001033775 4933422H20Rik RIKEN cDNA 4933422H20 gene 1.49 NM_025753 4933425O20Rik RIKEN cDNA 4933425O20 gene 1.48 NM_175017 4933427D06Rik RIKEN cDNA 4933427D06 gene 1.73 NM_001033424 5031408O05Rik RIKEN cDNA 5031408O05 gene 1.48 NM_207657 5031410I06Rik RIKEN cDNA 5031410I06 gene 1.42 NM_029493 5033413D22Rik RIKEN cDNA 5033413D22 gene 1.46 NM_027789 5430416O09Rik RIKEN cDNA 5430416O09 gene 1.55 NM_175165 5430420C16Rik RIKEN cDNA 5430420C16 gene 1.41 NM_010667 5430421N21Rik RIKEN cDNA 5430421N21 gene 1.57 NM_026636 5430437P03Rik RIKEN cDNA 5430437P03 gene 1.45 NM_025679 5730470L24Rik RIKEN cDNA 5730470L24 gene 1.41 NM_178243 5830403L16Rik RIKEN cDNA 5830403L16 gene 1.58 NM_029998 6030458C11Rik RIKEN cDNA 6030458C11 gene 1.42 NM_183126 6030498E09Rik RIKEN cDNA 6030498E09 gene 1.45 NM_001039586 6230410P16Rik RIKEN cDNA 6230410P16 gene 1.41 NM_178689 6430537H07Rik RIKEN cDNA 6430537H07 gene 1.50 NM_001033776 7420416P09Rik RIKEN cDNA 7420416P09 gene 1.54 NM_030135 8030411F24Rik RIKEN cDNA 8030411F24 gene 1.57 NM_201360 9030605E09Rik RIKEN cDNA 9030605E09 gene 1.44 NM_027840 9130017C17Rik RIKEN cDNA 9130017C17 gene 1.57 NM_177820 9130218O11Rik RIKEN cDNA 9130218O11 gene 1.42 NM_199017 9230110C19Rik RIKEN cDNA 9230110C19 gene 1.68 NM_026566 9430023L20Rik RIKEN cDNA 9430023L20 gene 1.43 NM_176943 9630028B13Rik RIKEN cDNA 9630028B13 gene 1.45 NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene 1.94 NM_183194 9930109F21Rik RIKEN cDNA 9930109F21 gene 1.41 NM_020591 A030009H04Rik RIKEN cDNA A030009H04 gene 1.66 NM_153409 A330102K23Rik RIKEN cDNA A330102K23 gene 1.69 NM_001009819 A3galt2 Alpha 1,3- 2 (isoglobotriaosylceramide synthase) 1.63 NM_178767 A530016O06Rik RIKEN cDNA A530016O06 gene 1.49 NM_213615 A530032D15Rik RIKEN cDNA A530032D15Rik gene 1.44 NM_177248 A630005I04Rik RIKEN cDNA A630005I04 gene 1.42 NM_175449 A630077B13Rik RIKEN cDNA A630077B13 gene 1.46 NM_173759 A730017C20Rik RIKEN cDNA A730017C20 gene 1.44 NM_175268 A930008G19Rik RIKEN cDNA A930008G19 gene 1.42 NM_133954 AA960436 Expressed sequence AA960436 1.56 NM_146217 Aars Alanyl-tRNA synthetase 1.42 NM_008830 Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.53 NM_172912 Abcc12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 1.45 NM_008992 Abcd4 ATP-binding cassette, sub-family D (ALD), member 4 1.51 NM_011920 Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 1.44 NM_172511 Abhd10 Abhydrolase domain containing 10 1.42 ABO blood group ( A, alpha 1-3-N-acetylgalactosaminyltransferase, NM_030718 Abo transferase B, alpha 1-3-galactosyltransferase) 1.56 NM_178308 Abpg Androgen binding protein gamma 1.57 NM_001034013 Accn1 -sensitive cation channel 1, neuronal (degenerin) 1.46 NM_146197 Acsm2 Acyl-CoA synthetase medium-chain family member 2 1.43 NM_025271 Actl7b Actin-like 7b 1.77 NM_033268 Actn2 1.51 NM_172125 Adam1b A disintegrin and metallopeptidase domain 1b 1.49 NM_027665 Adam30 A disintegrin and metallopeptidase domain 30 1.50 NM_019655 Adar , RNA-specific 1.56 NM_133883 Adprhl2 ADP-ribosylhydrolase like 2 1.65 NM_013464 Ahr Aryl-hydrocarbon receptor 1.47 NM_172391 Ahsa2 AHA1, activator of ATPase homolog 2 (yeast) 2.15

10 NM_001033210 AI427122 Expressed sequence AI427122 1.44 NM_177869 AI847670 Expressed sequence AI847670 1.46 NM_177912 AI987692 Expressed sequence AI987692 1.49 NM_025337 Akr7a5 Aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) 1.44 NM_010241 Aktip Thymoma viral proto-oncogene 1 interacting protein 1.56 NM_020559 Alas1 Aminolevulinic acid synthase 1 1.60 NM_009654 Alb Albumin 1.55 NM_178713 Aldh8a1 Aldehyde dehydrogenase 8 family, member A1 1.46 NM_019871 Amac1 Acyl-malonyl condensing 1 1.44 NM_008537 Amacr Alpha-methylacyl-CoA racemase 1.45 NM_033603 Amn Amnionless 1.47 NM_008569 Anapc1 Anaphase promoting complex subunit 1 1.51 NM_007426 Angpt2 Angiopoietin 2 1.46 NM_170728 Ank3 Ankyrin 3, epithelial 1.44 NM_145611 Ankrd25 Ankyrin repeat domain 25 1.48 NM_144790 Ankrd33 Ankyrin repeat domain 33 1.51 NM_029898 Ankrd55 Ankyrin repeat domain 55 1.46 NM_028390 Anln Anillin, actin binding protein (scraps homolog, Drosophila) 1.47 NM_008486 Anpep Alanyl (membrane) 1.46 NM_172808 Antxrl Anthrax toxin receptor-like 1.57 NM_001008419 Aox3l1 Aldehyde oxidase 3-like 1 1.50 NM_019456 Apbb1ip Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 1.61 NM_009692 Apoa1 Apolipoprotein A-I 1.42 NM_030255 Apobec3 Apolipoprotein B editing complex 3 1.60 NM_009695 Apoc2 Apolipoprotein C-II 1.56 NM_013475 Apoh Apolipoprotein H 1.45 NM_133996 Apon Apolipoprotein N 1.49 NM_175087 Aqp6 6 1.49 NM_029270 Arhgap24 Rho GTPase activating protein 24 1.56 NM_177566 Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 1.46 NM_027871 Arhgef3 Rho guanine nucleotide exchange factor (GEF) 3 1.45 NM_024191 Arl2bp ADP-ribosylation factor-like 2 binding protein 1.47 NM_026034 Armc10 Armadillo repeat containing 10 1.41 NM_019915 Art2b ADP-ribosyltransferase 2b 1.64 NM_020577 As3mt Arsenic (+3 oxidation state) methyltransferase 1.42 NM_175731 Asah3 N-acylsphingosine (alkaline ) 3 1.58 NM_025758 Asb17 Ankyrin repeat and SOCS box-containing protein 17 1.48 NM_026877 Aspscr1 Alveolar soft part sarcoma region, candidate 1 (human) 1.44 NM_175650 Atp13a5 ATPase type 13A5 1.42 NM_018731 Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 1.45 NM_007507 Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e 1.78 NM_134157 Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 1.45 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_001031622 AU018829 Expressed sequence AU018829 1.43 NM_020572 Aurkc C 1.45 NM_028844 Aven Apoptosis, caspase activation inhibitor 1.69 NM_019404 Avpr2 vasopressin receptor 2 1.44 NM_199313 AY053573 CDNA sequence AY053573 1.53 NM_001018019 AY616753 CDNA sequence, AY616753 1.70 NM_020283 B3galt1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 1.64 NM_029792 B3gat1 Beta-1,3-glucuronyltransferase 1 ( P) 1.58 NM_172124 B3gat2 Beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) 1.61 NM_001024560 B930037P14Rik RIKEN cDNA B930037P14 gene 1.44 NM_001008502 Bbs12 Bardet-Biedl syndrome 12 (human) 1.51 NM_144832 BC017643 CDNA sequence BC017643 1.77 NM_001033284 BC026585 CDNA sequence BC026585 1.51 NM_027498 BC033915 CDNA sequence BC033915 1.43

11 NM_001008549 BC043301 CDNA sequence BC043301 1.68 NM_001001179 BC048546 CDNA sequence BC048546 1.46 NM_175020 BC048599 CDNA sequence BC048599 1.56 NM_207524 BC049702 CDNA sequence BC049702 1.52 NM_198667 BC061212 CDNA sequence BC061212 1.42 NM_198667 BC061212 CDNA sequence BC061212 1.42 NM_198667 BC061212 CDNA sequence BC061212 1.42 NM_021486 Bcmo1 Beta-carotene 15,15'- 1.42 NM_007539 Bdkrb1 receptor, beta 1 1.44 NM_007541 Bglap1 Bone gamma carboxyglutamate protein 1 1.46 NM_010871 Birc1f Baculoviral IAP repeat-containing 1f 1.44 NM_001012273 Birc5 Baculoviral IAP repeat-containing 5 1.48 NM_008528 Blnk B-cell linker 1.42 NM_009756 Bmp10 Bone morphogenetic protein 10 1.44 NM_009758 Bmpr1a Bone morphogenetic protein receptor, type 1A 1.44 NM_026975 Bola1 BolA-like 1 (E. coli) 1.55 NM_029426 Brsk2 BR / kinase 2 1.44 NM_001037719 Btla B and T lymphocyte associated 1.55 NM_009773 Bub1b Budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 1.48 NM_020558 C1d Nuclear DNA binding protein 1.49 NM_001002792 C230029F24Rik RIKEN cDNA C230029F24 gene 1.44 NM_146016 C230094A16Rik RIKEN cDNA C230094A16 gene 1.43 NM_011413 C4a Complement component 4A (Rodgers blood group) 1.42 NM_016704 C6 Complement component 6 1.50 NM_011274 C80913 Expressed sequence C80913 1.68 NM_198663 C87499 Expressed sequence C87499 1.41 NM_146148 C8a Complement component 8, alpha polypeptide 1.45 NM_133882 C8b Complement component 8, beta subunit 1.54 NM_145851 Cables2 Cdk5 and Abl enzyme 2 1.46 NM_178721 Cadm2 molecule 2 1.49 NM_007605 Capza3 Capping protein (actin filament) muscle Z-line, alpha 3 1.46 NM_009799 Car1 1 1.48 NM_178396 Car12 Carbonic anyhydrase 12 1.41 NM_009802 Car6 Carbonic anhydrase 6 1.55 NM_175362 Card11 Caspase recruitment domain family, member 11 1.65 NM_009809 Casp14 Caspase 14 1.59 NM_009810 Casp3 Caspase 3 1.76 NM_007609 Casp4 Caspase 4, apoptosis-related peptidase 1.51 NM_007617 Cav3 3 1.44 NM_021609 Ccbp2 binding protein 2 1.42 NM_175369 Ccdc122 Coiled-coil domain containing 122 1.44 NM_028804 Ccdc3 Coiled-coil domain containing 3 1.43 NM_029212 Ccdc33 Coiled-coil domain containing 33 1.53 NM_175430 Ccdc40 Coiled-coil domain containing 40 1.59 NM_029606 Ccdc46 Coiled-coil domain containing 46 1.60 NM_001012309 Ccdc55 Coiled-coil domain containing 55 1.42 NM_181816 Ccdc67 Coiled-coil domain containing 67 1.43 NM_133744 Ccdc71 Coiled-coil domain containing 71 1.55 NM_201372 Ccdc84 Coiled-coil domain containing 84 1.52 NM_207268 Ccdc87 Coiled-coil domain containing 87 1.67 NM_011330 Ccl11 Small chemokine (C-C motif) 11 1.62 NM_011333 Ccl2 Chemokine (C-C motif) ligand 2 1.45 NM_019577 Ccl24 Chemokine (C-C motif) ligand 24 1.64 NM_001013412 Ccl26l Chemokine (C-C motif) ligand 26-like 1.49 NM_007632 Ccnd3 D3 1.43 NM_009912 Ccr1 Chemokine (C-C motif) receptor 1 1.44 NM_007718 Ccr1l1 Chemokine (C-C motif) receptor 1-like 1 1.48 NM_172909 Cd163l1 CD163 molecule-like 1 1.48 NM_007639 Cd1d1 CD1d1 1.43 NM_134158 Cd300d Cd300D antigen 1.41 NM_013488 Cd4 CD4 antigen 1.45 NM_007652 Cd59a CD59a antigen 1.61 NM_009690 Cd5l CD5 antigen-like 1.45 NM_009855 Cd80 CD80 antigen 1.45

12 NM_013489 Cd84 CD84 antigen 1.53 NM_178626 Cdc42se2 CDC42 small effector 2 1.57 NM_011800 Cdh20 20 1.42 NM_001033443 Cdkl4 Cyclin-dependent kinase-like 4 1.52 NM_029976 Cdkn2aipnl CDKN2A interacting protein N-terminal like 1.57 NM_021339 Cdon -related/down-regulated by oncogenes 1.48 NM_025496 Cdrt4 CMT1A duplicated region transcript 4 1.76 NM_007543 Ceacam2 CEA-related cell adhesion molecule 2 1.52 NM_144815 Cecr5 Cat eye syndrome chromosome region, candidate 5 homolog (human) 1.42 NM_207298 Ceecam1 Cerebral endothelial cell adhesion molecule 1 1.54 NM_177150 Cenpt Centromere protein T 1.62 NM_028959 Cep72 Centrosomal protein 72 1.42 NM_145603 Ces2 2 1.57 NM_053200 Ces3 Carboxylesterase 3 1.41 NM_024166 Chchd2 Coiled-coil-helix-coiled-coil-helix domain containing 2 1.49 NM_025351 Chchd6 Coiled-coil-helix-coiled-coil-helix domain containing 6 1.56 NM_029814 Chmp5 Chromatin modifying protein 5 1.62 NM_203491 Chrm2 Cholinergic receptor, muscarinic 2, cardiac 1.55 NM_021439 Chst11 sulfotransferase 11 1.44 NM_016803 Chst3 Carbohydrate (chondroitin 6/keratan) sulfotransferase 3 1.45 NM_198415 Ckmt2 kinase, mitochondrial 2 1.44 NM_009899 Clca1 activated 1 1.44 NM_139148 Clca4 Chloride channel calcium activated 4 1.61 NM_019701 Clcnkb Chloride channel Kb 1.47 NM_018778 Cldn8 Claudin 8 1.50 NM_001007223 Clec3a C-type lectin domain family 3, member a 1.56 NM_172732 Clec9a C-type lectin domain family 9, member a 1.44 NM_007713 Clk3 CDC-like kinase 3 1.59 NM_009907 Cln3 Ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) 1.51 NM_011802 Clpx Caseinolytic peptidase X (E.coli) 1.42 NM_153384 Clrn1 Clarin 1 1.50 NM_027022 Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 1.42 NM_028524 Cmtm2b CKLF-like MARVEL transmembrane domain containing 2B 1.69 NM_153582 Cmtm4 CKLF-like MARVEL transmembrane domain containing 4 1.48 NM_007724 Cnga2 Cyclic nucleotide gated channel alpha 2 1.71 NM_025771 Cntnap2 Contactin associated protein-like 2 1.50 NM_007732 Col17a1 Procollagen, type XVII, alpha 1 1.47 NM_001037865 Col28a1 , type XXVIII, alpha 1 1.48 NM_029635 Commd9 COMM domain containing 9 1.52 NM_015827 Copb2 protein complex, subunit beta 2 (beta prime) 1.45 NM_011991 Cops3 COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) 1.46 NM_178893 Coro2a Coronin, actin binding protein 2A 1.45 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 1.75 NM_030052 Cox7b2 Cytochrome c oxidase subunit VIIb2 1.45 NM_001039049 Cox8c Cytochrome c oxidase, subunit VIIIc 1.71 NM_027769 Cpne3 Copine III 1.44 NM_018867 Cpxm2 X 2 (M14 family) 1.54 NM_028798 Crct1 Cysteine-rich C-terminal 1 1.43 NM_009953 Crhr2 Corticotropin releasing 2 1.81 NM_013499 Crry Complement receptor related protein 1.48 NM_001033638 Crxos1 Crx opposite strand transcript 1 1.48 NM_009965 Cryba1 , beta A1 1.66 NM_007774 Cryga Crystallin, gamma A 1.53 NM_153076 Crygn Crystallin, gamma N 1.47 NM_007778 Csf1 Colony stimulating factor 1 () 1.54 NM_027945 Csl like 1.52 NM_027874 Csnk1d kinase 1, delta 1.57 NM_007792 Csrp2 Cysteine and -rich protein 2 1.51 NM_181417 Csrp2bp Cysteine and glycine-rich protein 2 binding protein 1.50 NM_030059 Cst11 Cystatin 11 1.49 NM_009978 Cst8 Cystatin 8 (cystatin-related epididymal spermatogenic) 1.46 NM_007793 Cstb Cystatin B 1.44 NM_009982 Ctsc 1.54 NM_009983 Ctsd Cathepsin D 1.44

13 NM_028288 Cul4b 4B 1.55 NM_009986 Cutl1 Cut-like 1 (Drosophila) 1.44 NM_008176 Cxcl1 Chemokine (C-X-C motif) ligand 1 1.49 NM_029787 Cyb5r3 Cytochrome b5 reductase 3 1.58 NM_011370 Cyfip1 Cytoplasmic FMR1 interacting protein 1 1.51 NM_009997 Cyp2a4 Cytochrome P450, family 2, subfamily a, polypeptide 4 1.57 NM_007812 Cyp2a5 Cytochrome P450, family 2, subfamily a, polypeptide 5 1.48 NM_009999 Cyp2b10 Cytochrome P450, family 2, subfamily b, polypeptide 10 1.52 NM_028089 Cyp2c55 Cytochrome P450, family 2, subfamily c, polypeptide 55 1.41 NM_145474 Cyp2d34 Cytochrome P450, family 2, subfamily d, polypeptide 34 1.64 NM_010006 Cyp2d9 Cytochrome P450, family 2, subfamily d, polypeptide 9 1.48 NM_019792 Cyp3a25 Cytochrome P450, family 3, subfamily a, polypeptide 25 1.46 NM_017396 Cyp3a41a Cytochrome P450, family 3, subfamily a, polypeptide 41A 1.43 NM_017396 Cyp3a41a Cytochrome P450, family 3, subfamily a, polypeptide 41A 1.43 NM_177380 Cyp3a44 Cytochrome P450, family 3, subfamily a, polypeptide 44 1.50 NM_130882 Cyp4f13 Cytochrome P450, family 4, subfamily f, polypeptide 13 1.43 NM_022434 Cyp4f14 Cytochrome P450, family 4, subfamily f, polypeptide 14 1.45 NM_008455 Cyp4v3 Cytochrome P450, family 4, subfamily v, polypeptide 3 1.50 NM_145462 D14Ertd500e DNA segment, Chr 14, ERATO Doi 500, expressed 1.63 NM_177464 D19Ertd386e DNA segment, Chr 19, ERATO Doi 386, expressed 1.47 NM_001037740 D330017J20Rik RIKEN cDNA D330017J20 gene 1.43 NM_146057 Dap Death-associated protein 1.71 NM_010023 Dci Dodecenoyl-Coenzyme A delta (3,2 trans-enoyl-Coenyme A isomerase) 1.46 NM_007832 Dck 1.42 NM_001039238 Dcpp2 Demilune cell and parotid protein 2 1.54 NM_016890 Dctn3 Dynactin 3 1.56 NM_016672 Ddc Dopa decarboxylase 1.60 NM_010026 Ddef1 Development and differentiation enhancing 1.57 NM_199080 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 1.68 NM_027156 Ddx51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 1.48 NM_054046 Def8 Differentially expressed in FDCP 8 1.42 NM_145157 Defb19 Defensin beta 19 1.52 NM_176950 Defb20 Defensin beta 20 1.43 NM_001034910 Defb42 Defensin beta 42 1.45 NM_018769 Dfna5h Deafness, autosomal dominant 5 homolog (human) 1.46 NM_138650 Dgkg , gamma 1.42 NM_026191 Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1.53 NM_001024474 Diras2 DIRAS family, GTP-binding RAS-like 2 1.54 NM_007769 Dmbt1 Deleted in malignant brain tumors 1 1.47 NM_028618 Dmkn Dermokine 1.44 NM_021422 Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 1.58 NM_007869 Dnajc1 DnaJ (Hsp40) homolog, subfamily C, member 1 1.44 NM_017470 Dnalc4 Dynein, axonemal, chain 4 1.57 NM_007870 Dnase1l3 1-like 3 1.46 NM_019957 Dnase2b Deoxyribonuclease II beta 1.41 NM_176913 Dpep2 2 1.55 NM_013504 Dsc1 1 1.54 NM_007834 Dscr3 Down syndrome critical region gene 3 1.62 NM_181682 Dsg1b 1 beta 1.69 NM_025853 Dsn1 DSN1, MIND complex component, homolog (S. cerevisiae) 1.54 NM_010091 Dvl1 , dsh homolog 1 (Drosophila) 1.46 NM_007888 Dvl2 Dishevelled 2, dsh homolog (Drosophila) 1.45 NM_030238 Dync1h1 Dynein cytoplasmic 1 heavy chain 1 1.48 NM_009342 Dynlt1 Dynein light chain Tctex-type 1 1.51 NM_028258 Dzip1l DAZ interacting protein 1-like 1.49 NM_001008973 E130009J12Rik RIKEN cDNA E130009J12 gene 1.45 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 1.70 NM_139293 Ece2 Endothelin converting enzyme 2 1.47 NM_007904 Ednrb Endothelin receptor type B 1.47 NM_177593 EG210155 Predicted gene, EG210155 1.41 NM_177665 EG229862 Predicted gene, EG229862 1.63 NM_177890 EG233164 Predicted gene, EG233164 1.55 NM_183166 EG233164 Predicted gene, EG233164 1.56 NM_177808 EG328231 Predicted gene, EG328231 1.50

14 NM_001033540 EG330503 Predicted gene, EG330503 1.44 NM_183320 EG331529 Predicted gene, EG331529 1.49 NM_183320 EG331529 Predicted gene, EG331529 1.49 NM_001004158 EG380907 Predicted gene, EG380907 1.52 NM_198657 EG381438 Predicted gene, EG381438 1.82 NM_001037248 EG381936 Predicted gene, EG381936 1.43 NM_001037248 EG381936 Predicted gene, EG381936 1.43 NM_001004162 EG432436 Predicted gene, EG432436 1.47 NM_001013788 EG432743 Predicted gene, EG432743 1.49 NM_001004182 EG434008 Predicted gene, EG434008 1.44 NM_001033782 EG434172 Predicted gene, EG434172 1.45 NM_001033783 EG434396 Predicted gene, EG434396 1.44 NM_001038697 EG434729 Predicted gene, EG434729 1.49 NM_001034893 EG435970 Predicted gene, EG435970 1.42 NM_001024147 EG545758 Predicted gene, EG545758 1.47 NM_001037931 EG628416 Predicted gene, EG628416 1.43 NM_001039119 EG654453 Predicted gene, EG654453 1.41 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) 1.43 NM_053252 Ehbp1l1 EH domain binding protein 1-like 1 1.61 NM_001033269 Eif4e1b Eukaryotic initiation factor 4E family member 1B 1.42 NM_177586 Eif5a2 Eukaryotic translation initiation factor 5A2 1.49 NM_010579 Eif6 Eukaryotic translation initiation factor 6 1.59 NM_080288 Elmo1 Engulfment and cell motility 1, ced-12 homolog (C. elegans) 1.71 NM_080287 Elmo2 Engulfment and cell motility 2, ced-12 homolog (C. elegans) 1.47 NM_019423 Elovl2 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 1.65 NM_016885 Emcn Endomucin 1.54 NM_013509 Eno2 2, gamma neuronal 1.60 NM_001030291 Enpp7 Ectonucleotide / 7 1.50 NM_013511 Epb4.1l2 Erythrocyte protein band 4.1-like 2 1.50 NM_145506 Epb4.1l5 Erythrocyte protein band 4.1-like 5 1.59 NM_007939 Epha8 Eph receptor A8 1.46 NM_007946 Epx 1.45 NM_007884 Epyc Epiphycan 1.42 NM_007951 Erh Enhancer of rudimentary homolog (Drosophila) 1.47 NM_001034862 Erich1 Glutamate-rich 1 1.42 NM_007954 Es1 1 1.45 NM_026695 Etfb Electron transferring , beta polypeptide 1.50 NM_016857 Exoc7 Exocyst complex component 7 1.42 NM_144886 Exosc2 Exosome component 2 1.41 NM_010170 F2rl2 factor II () receptor-like 2 1.63 NM_025923 Fancl Fanconi anemia, complementation group L 1.45 NM_175530 Fbxo46 F-box protein 46 1.43 NM_001033669 Fbxw10 F-box and WD-40 domain protein 10 1.61 NM_175401 Fbxw17 F-box and WD-40 domain protein 17 1.45 NM_010190 Fcnb Ficolin B 1.59 NM_001029984 Fcrlb Fc receptor-like B 1.65 NM_015759 Fgd3 FYVE, RhoGEF and PH domain containing 3 1.51 NM_172731 Fgd5 FYVE, RhoGEF and PH domain containing 5 1.45 NM_053072 Fgd6 FYVE, RhoGEF and PH domain containing 6 1.57 NM_010197 Fgf1 Fibroblast growth factor 1 1.64 NM_019873 Fkbpl FK506 binding protein-like 1.54 NM_008030 Fmo3 Flavin containing monooxygenase 3 1.44 NM_008034 Folr1 receptor 1 (adult) 1.45 NM_008239 Foxq1 Forkhead box Q1 1.48 NM_177136 Fryl Furry homolog-like (Drosophila) 1.46 NM_008047 Fstl1 Follistatin-like 1 1.54 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 1.41 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 1.41 GA_x5J8B7W2BV0- NM_146333 3116-4045 Olfactory receptor GA_x5J8B7W2BV0-3116-4045 1.45 NM_008075 Gabrr1 Gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1 1.96 NM_199366 Gal3st2 Galactose-3-O-sulfotransferase 2 1.46 NM_180678 Gars Glycyl-tRNA synthetase 1.55 NM_008088 Gas7 Growth arrest specific 7 1.44

15 NM_010257 Gast Gastrin 1.44 NM_025961 Gatm Glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.55 NM_008103 Gcm1 Glial cells missing homolog 1 (Drosophila) 1.41 NM_008376 Gimap1 GTPase, IMAP family member 1 1.53 NM_018771 Gipc1 GIPC PDZ domain containing family, member 1 1.46 NM_008120 Gja4 protein alpha 4 1.43 NM_008123 Gja8 Gap junction membrane channel protein alpha 8 1.47 NM_010290 Gja9 Gap junction membrane channel protein alpha 9 1.43 NM_008124 Gjb1 Gap junction membrane channel protein beta 1 1.44 NM_010291 Gjb5 Gap junction membrane channel protein beta 5 1.55 NM_019832 Gkap1 G kinase anchoring protein 1 1.44 NM_025467 Gkn2 Gastrokine 2 1.45 NM_138595 Gldc Glycine decarboxylase 1.43 NM_028923 Gle1l GLE1 RNA export mediator-like (yeast 1.57 NM_175681 Glp2r -like 2 receptor 1.42 NM_198612 Glt8d4 8 domain containing 4 1.41 NM_145935 Glyat Glycine-N- 1.73 NM_001004161 Gm1082 Gene model 1082, (NCBI) 1.44 NM_001033473 Gm1157 Gene model 1157, (NCBI) 1.50 NM_001033403 Gm1968 Gene model 1968, (NCBI) 1.45 NM_001013765 Gm397 Gene model 397, (NCBI) 1.48 NM_001018031 Gm414 Gene model 414, (NCBI) 2.03 NM_001013751 Gm52 Gene model 52, (NCBI) 1.53 NM_001033252 Gm732 Gene model 732, (NCBI) 1.58 NM_001033407 Gm815 Gene model 815, (NCBI) 1.48 NM_001033426 Gm851 Gene model 851, (NCBI) 1.45 NM_010305 Gnai1 Guanine nucleotide binding protein, alpha inhibiting 1 1.44 NM_008138 Gnai2 Guanine nucleotide binding protein, alpha inhibiting 2 1.46 NM_178846 Gnl3 Guanine nucleotide binding protein-like 3 (nucleolar) 1.41 NM_027352 Gorasp2 Golgi reassembly stacking protein 2 1.42 NM_025989 Gp2 2 ( granule membrane) 1.80 NM_008147 Gp49a Glycoprotein 49 A 1.67 NM_025663 Gpatch4 G patch domain containing 4 1.52 NM_175380 Gpd1l Glycerol-3-phosphate dehydrogenase 1-like 1.50 NM_133776 Gpr110 -coupled receptor 110 1.62 NM_001033493 Gpr111 G protein-coupled receptor 111 1.61 NM_001002268 Gpr126 G protein-coupled receptor 126 1.47 NM_008157 Gpr19 G protein-coupled receptor 19 1.59 NM_001013832 Gpr31c G protein-coupled receptor 31, D17Leh66c region 1.53 NM_008159 Gpr33 G protein-coupled receptor 33 1.52 NM_022320 Gpr35 G protein-coupled receptor 35 1.42 NM_134438 Gpr37l1 G protein-coupled receptor 37-like 1 1.48 NM_175493 Gpr68 G protein-coupled receptor 68 1.47 NM_030677 Gpx2 Glutathione peroxidase 2 1.46 NM_010343 Gpx5 Glutathione peroxidase 5 1.49 NM_001033498 Gramd2 GRAM domain containing 2 1.48 NM_011938 Grk6 G protein-coupled receptor kinase 6 1.49 NM_008175 Grn Granulin 1.42 NM_025768 Grtp1 GH regulated TBC protein 1 1.48 NM_011153 Gsbs G substrate 1.42 NM_026764 Gstm4 Glutathione S-transferase, mu 4 1.55 NM_023630 Gtf2a1l General transcription factor IIA, 1-like 1.44 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 1.46 NM_025332 Gtpbp8 GTP-binding protein 8 (putative) 1.52 NM_145067 Gucy2c 2c 1.48 NM_008193 Guk1 1 1.55 NM_010293 Gykl1 -like 1 1.60 NM_013542 Gzmb 1.64 NM_027304 H1fnt H1 histone family, member N, testis-specific 1.48 NM_207105 H2-Ab1 Histocompatibility 2, class II antigen A, beta 1 1.50 NM_010381 H2-Ea Histocompatibility 2, class II antigen E alpha 1.49 NM_177636 H2-M1 Histocompatibility 2, M region 1 1.42 NM_177635 H2-M11 Histocompatibility 2, M region locus 11 1.50 NM_008205 H2-M9 Histocompatibility 2, M region locus 9 1.44

16 NM_010395 H2-T10 Histocompatibility 2, T region locus 10 1.44 NM_134248 Havcr1 Hepatitis A virus cellular receptor 1 1.42 NM_011827 Hcst Hematopoietic cell signal transducer 1.54 NM_207225 Hdac4 4 1.65 NM_008232 Hdgfl1 Hepatoma derived growth factor-like 1 1.48 Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 NM_010418 Herc2 (CHC1)-like domain (RLD) 2 1.44 NM_013547 Hgd Homogentisate 1, 2- 1.65 NM_010427 Hgf growth factor 1.52 NM_018792 Hils1 Histone H1-like protein in spermatids 1 1.46 NM_025798 Hint3 triad nucleotide binding protein 3 1.45 NM_010377 Hist1h1t Histone cluster 1, H1t 1.52 NM_001033245 Hk3 3 1.51 NM_009210 Hltf -like transcription factor 1.45 NM_175606 Hopx HOP 1.60 NM_174998 Hpcal4 -like 4 1.46 NM_010474 Hs3st1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 1.61 NM_027661 Hsfy2 Heat shock transcription factor, Y linked 2 1.63 NM_013558 Hspa1l Heat shock protein 1-like 1.57 NM_008309 Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 1.43 NM_028752 Hvcn1 Hydrogen voltage-gated channel 1 1.63 NM_010491 Iapp Islet amyloid polypeptide 1.46 NM_023892 Icam4 Intercellular adhesion molecule 4, Landsteiner-Wiener blood group 1.48 NM_031156 Ide degrading enzyme 1.44 NM_177197 Idi2 Isopentenyl-diphosphate delta isomerase 2 1.41 NM_133871 Ifi44 -induced protein 44 1.47 NM_026820 Ifitm1 Interferon induced 1 1.47 NM_053088 Ifitm5 Interferon induced transmembrane protein 5 1.49 NM_001033632 Ifitm6 Interferon induced transmembrane protein 6 1.42 NM_028742 Ifltd1 tail domain containing 1 1.47 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 1.46 NM_010546 Ikbkb Inhibitor of kappaB kinase beta 1.75 NM_010549 Il11ra1 receptor, alpha chain 1 1.47 NM_008355 Il13 1.47 NM_133836 Il15ra receptor, alpha chain 1.51 NM_010551 Il16 1.57 NM_019450 Il1f6 Interleukin 1 family, member 6 1.49 NM_008362 Il1r1 Interleukin 1 receptor, type I 1.57 NM_010555 Il1r2 Interleukin 1 receptor, type II 1.55 NM_008364 Il1rap Interleukin 1 receptor accessory protein 1.48 NM_010743 Il1rl1 Interleukin 1 receptor-like 1 1.60 NM_133193 Il1rl2 Interleukin 1 receptor-like 2 1.47 NM_145636 Il27 Interleukin 27 1.43 NM_013563 Il2rg receptor, gamma chain 1.42 NM_178241 Il8ra receptor, alpha 1.44 NM_023343 Ilkap -linked kinase-associated serine/threonine 2C 1.42 NM_177730 Impad1 Inositol monophosphatase domain containing 1 1.45 NM_001005784 Inadl InaD-like (Drosophila) 1.50 NM_008381 Inhbb Inhibin beta-B 1.43 NM_001024617 Inpp4b Inositol polyphosphate-4-phosphatase, type II 1.48 NM_010566 Inpp5d Inositol polyphosphate-5-phosphatase D 1.42 NM_008386 Ins1 Insulin I 1.58 NM_022655 Ireb2 responsive element binding protein 2 1.43 NM_176922 Itga11 Integrin, alpha 11 1.59 NM_008396 Itga2 1.43 NM_001029872 Itgad Integrin, alpha D 1.54 NM_008400 Itgal 1.45 NM_010582 Itih2 Inter-alpha inhibitor, heavy chain 2 1.59 NM_010587 Itsn1 Intersectin 1 (SH3 domain protein 1A) 1.49 NM_173001 Jmjd1a Jumonji domain containing 1A 1.53 NM_030887 Jundm2 2 1.45 NM_010594 Kap androgen regulated protein 1.47 NM_001031811 Kcnh8 Potassium voltage-gated channel, subfamily H (eag-related), member 8 1.44 NM_001031811 Kcnh8 Potassium voltage-gated channel, subfamily H (eag-related), member 8 1.44

17 NM_030265 Kcnip4 Kv channel interacting protein 4 1.51 NM_010602 Kcnj11 Potassium inwardly rectifying channel, subfamily J, member 11 1.41 NM_001025590 Kcnj6 Potassium inwardly-rectifying channel, subfamily J, member 6 1.41 NM_001012434 Kctd14 tetramerisation domain containing 14 1.52 NM_010613 Khsrp KH-type splicing regulatory protein 1.48 NM_010615 Kif11 family member 11 1.43 NM_134471 Kif2c Kinesin family member 2C 1.46 NM_008443 Kif3a Kinesin family member 3A 1.54 NM_177748 Kir3dl2 Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 1.48 NM_178260 Kiss1 KiSS-1 metastasis-suppressor 1.45 NM_178771 Klhl26 Kelch-like 26 (Drosophila) 1.52 NM_174865 Klk15 related-peptidase 15 1.79 NM_010645 Klk1b1 Kallikrein 1-related peptidase b1 1.54 NM_010643 Klk1b24 Kallikrein 1-related peptidase b24 1.45 NM_010644 Klk1b26 Kallikrein 1-related petidase b26 1.45 NM_020268 Klk1b27 Kallikrein 1-related peptidase b27 1.50 NM_008457 Klk1b8 Kallikrein 1-related peptidase b8 1.45 NM_019928 Klk4 Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) 1.94 NM_010652 Klrc1 Killer cell lectin-like receptor subfamily C, member 1 1.46 NM_010653 Klrc2 Killer cell lectin-like receptor subfamily C, member 2 1.49 NM_010654 Klrd1 Killer cell lectin-like receptor, subfamily D, member 1 1.42 NM_033078 Klrk1 Killer cell lectin-like receptor subfamily K, member 1 1.56 NM_001039124 Kncn Kinocilin 1.65 NM_008470 Krt16 16 1.44 NM_010659 Krt31 Keratin 31 1.52 NM_010665 Krt32 Keratin 32 1.70 NM_027983 Krt33a Keratin 33A 1.46 NM_027563 Krt34 1.44 NM_213730 Krt39 Keratin 39 1.58 NM_008475 Krt4 1.48 NM_019956 Krt71 Keratin 71 1.42 NM_130870 Krtap16-1 Keratin associated protein 16-1 1.62 NM_130876 Krtap16-2 Keratin associated protein 16-2 1.49 NM_010676 Krtap8-2 Keratin associated protein 8-2 1.47 NM_008477 Ktn1 Kinectin 1 1.51 NM_008482 Lamb1-1 Laminin B1 subunit 1 1.42 NM_008484 Lamb3 Laminin, beta 3 1.55 NM_138593 Larp7 La ribonucleoprotein domain family, member 7 1.56 NM_026058 Lass4 Longevity assurance homolog 4 (S. cerevisiae) 1.42 NM_025420 Lce1m Late cornified envelope 1M 1.50 NM_153558 Lcn13 Lipocalin 13 1.44 NM_010695 Lcn4 Lipocalin 4 1.58 NM_007947 Lcn5 Lipocalin 5 1.51 NM_145835 Lctl Lactase-like 1.55 NM_001033979 Ldlrad2 Low density lipoprotein receptor A domain containing 2 1.47 NM_177630 Ldoc1l zipper, down-regulated in cancer 1-like 1.41 NM_146075 Lemd2 LEM domain containing 2 1.42 NM_177763 Lhfpl4 Lipoma HMGIC fusion partner-like protein 4 1.49 NM_010710 Lhx2 LIM homeobox protein 2 1.42 NM_008280 Lipc , hepatic 1.54 NM_172837 Lipk Lipase, family member K 1.56 NM_053098 Lmod2 Leiomodin 2 (cardiac) 1.47 NM_001009548 LOC384806 Similar to testase-8 1.45 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 1.59 NM_001039646 LOC626578 Macrophage activation 2 like LOC626578 1.49 NM_010728 Lox 1.43 NM_029796 Lrg1 Leucine-rich alpha-2-glycoprotein 1 1.54 NM_053073 Lrp8 Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1.41 NM_013588 Lrrc23 Leucine rich repeat containing 23 1.43 NM_001033346 Lrrc55 Leucine rich repeat containing 55 1.47 NM_019391 Lsp1 Lymphocyte specific 1 1.46 NM_146006 Lss 1.53 NM_010741 Ly6c1 Lymphocyte antigen 6 complex, locus C1 1.43 NM_010745 Ly86 Lymphocyte antigen 86 1.57

18 NM_153121 Lysmd1 LysM, putative peptidoglycan-binding, domain containing 1 1.52 NM_017372 Lyzs Lysozyme 1.44 NM_001013802 Macrod2 MACRO domain containing 2 1.55 NM_020015 Magea1 Melanoma antigen, family A, 1 1.55 NM_020017 Magea3 Melanoma antigen, family A, 3 1.68 NM_020280 Magea4 Melanoma antigen, family A, 4 1.42 NM_031171 Mageb2 Melanoma antigen, family B, 2 1.48 NM_031171 Mageb2 Melanoma antigen, family B, 2 1.48 NM_053206 Magee2 Melanoma antigen, family E, 2 1.44 NM_015823 Magi2 Membrane associated guanylate kinase, WW and PDZ domain containing 2 1.46 NM_001004176 Maml3 Mastermind like 3 (Drosophila) 1.65 NM_010763 Man1a2 Mannosidase, alpha, class 1A, member 2 1.44 NM_008928 Map2k3 Mitogen activated protein kinase kinase 3 1.52 NM_016896 Map3k14 Mitogen-activated protein kinase kinase kinase 14 1.43 NM_021921 Mapk8ip2 Mitogen-activated protein kinase 8 interacting protein 2 1.43 NM_013931 Mapk8ip3 Mitogen-activated protein kinase 8 interacting protein 3 1.54 NM_011843 Mbc2 Membrane bound containing protein 1.49 NM_010775 Mbl1 Mannose binding lectin (A) 1.59 NM_025676 Mcm8 Minichromosome maintenance deficient 8 (S. cerevisiae) 1.52 NM_145494 Me2 Malic enzyme 2, NAD(+)-dependent, mitochondrial 1.50 NM_025397 Med11 Mediator of RNA II transcription, subunit 11 homolog (S. cerevisiae) 1.45 NM_053172 Mepe Matrix extracellular phosphoglycoprotein with ASARM motif (bone) 1.63 NM_025633 Metapl1 aminopeptidase-like 1 1.46 NM_172499 Mfsd9 Major facilitator superfamily domain containing 9 1.41 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 1.59 NM_177321 Mia2 Melanoma inhibitory activity 2 1.44 NM_027422 Mier2 Mesoderm induction early response 1, family member 2 1.65 NM_010798 Mif Macrophage migration inhibitory factor 1.44 NM_026178 Mmd to macrophage differentiation-associated 1.59 NM_175217 Mmd2 Monocyte to macrophage differentiation-associated 2 1.49 NM_008607 Mmp13 Matrix metallopeptidase 13 1.56 NM_032007 Mmp1b Matrix metallopeptidase 1b (interstitial collagenase) 1.52 NM_152944 Mmp21 Matrix metallopeptidase 21 1.50 NM_010810 Mmp7 Matrix metallopeptidase 7 1.64 NM_001033450 Mnda Myeloid cell nuclear differentiation antigen 1.53 NM_010816 Morc1 Microrchidia 1 1.48 NM_139296 Moxd2 Monooxygenase, DBH-like 2 1.51 NM_172610 Mpped1 Metallophosphoesterase domain containing 1 1.79 NM_203490 Mrgprd MAS-related GPR, member D 1.55 NM_011288 Mrpl23 Mitochondrial L23 1.57 NM_183086 Mrps10 Mitochondrial ribosomal protein S10 1.56 NM_010827 Msc Musculin 1.46 NM_054043 Msi2 Musashi homolog 2 (Drosophila) 1.44 NM_009074 Mst1r Macrophage stimulating 1 receptor (c-met-related kinase) 1.68 NM_008630 Mt2 2 1.50 NM_019758 Mtch2 Mitochondrial carrier homolog 2 (C. elegans) 1.47 NM_027134 Mtfmt Mitochondrial methionyl-tRNA formyltransferase 1.43 NM_029581 Mtif3 Mitochondrial translational initiation factor 3 1.48 NM_172958 Mtmr12 Myotubularin related protein 12 1.46 NM_028860 Mtmr3 Myotubularin related protein 3 1.41 NM_080457 Muc4 Mucin 4 1.45 NM_008506 Mycl1 V- myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) 1.46 NM_008669 Naga N-acetyl galactosaminidase, alpha 1.50 NM_013796 Nagpa N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 1.42 NM_025832 Narg1l NMDA receptor regulated 1-like 1.51 NM_153591 Nars2 Asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) 1.45 NM_010874 Nat2 N- 2 (arylamine N-acetyltransferase) 1.71 NM_133762 Ncapg2 Non-SMC condensin II complex, subunit G2 1.50 NM_031186 Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 1.58 NM_028177 Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 1.49 NM_010887 Ndufs4 NADH dehydrogenase (ubiquinone) Fe-S protein 4 1.57 NM_008682 Nedd1 Neural precursor cell expressed, developmentally down-regulated gene 1 1.57 NM_017464 Nedd9 Neural precursor cell expressed, developmentally down-regulated gene 9 1.41 NM_011848 Nek3 NIMA (never in mitosis gene a)-related expressed kinase 3 1.54

19 NM_007501 Neurod4 Neurogenic differentiation 4 1.41 NM_031375 Ngrn Neugrin, neurite outgrowth associated 1.63 NM_016718 Ninj2 Ninjurin 2 1.47 NM_080637 Nme5 Expressed in non-metastatic cells 5 1.43 NM_144533 Nmnat3 Nicotinamide nucleotide adenylyltransferase 3 1.50 NM_145857 Nod2 Nucleotide-binding oligomerization domain containing 2 1.44 NM_207242 Npc1l1 NPC1-like 1 1.76 NM_008722 Npm1 Nucleophosmin 1 1.49 NM_021892 Npvf Neuropeptide VF precursor 1.62 NM_010935 Npy6r Neuropeptide Y receptor Y6 1.44 NM_139051 Nr5a1 subfamily 5, group A, member 1 1.46 NM_145354 Nsun2 NOL1/NOP2/Sun domain family 2 1.42 NM_011955 Nubp1 Nucleotide binding protein 1 1.52 NM_026497 Nudt12 Nudix (nucleoside diphosphate linked moiety X)-type motif 12 1.73 NM_025529 Nudt8 Nudix (nucleoside diphosphate linked moiety X)-type motif 8 1.66 NM_010949 Numb Numb gene homolog (Drosophila) 1.71 NM_008750 Nxn Nucleoredoxin 1.48 NM_029173 Nxnl2 RIKEN cDNA 4930519N16 gene 1.52 NM_001011695 Olfr1000 Olfactory receptor 1000 1.45 NM_207149 Olfr1010 Olfactory receptor 1010 1.45 NM_146568 Olfr1012 Olfactory receptor 1012 1.52 NM_146762 Olfr1013 Olfactory receptor 1013 1.52 NM_146586 Olfr1018 Olfactory receptor 1018 1.49 NM_146587 Olfr1023 Olfactory receptor 1023 1.43 NM_001011774 Olfr1028 Olfactory receptor 1028 1.46 NM_147013 Olfr1038 Olfactory receptor 1038 1.47 NM_147017 Olfr1045 Olfactory receptor 1045 1.44 NM_146843 Olfr1097 Olfactory receptor 1097 1.55 NM_146328 Olfr110 Olfactory receptor 110 1.41 NM_147030 Olfr1134 Olfactory receptor 1134 1.46 NM_146647 Olfr1154 Olfactory receptor 1154 1.47 NM_001005225 Olfr1197 Olfactory receptor 1197 1.61 NM_001005227 Olfr1200 Olfactory receptor 1200 1.64 NM_146778 Olfr1208 Olfactory receptor 1208 1.54 NM_207140 Olfr1212 Olfactory receptor 1212 1.47 NM_001011796 Olfr1249 Olfactory receptor 1249 1.53 NM_146978 Olfr1258 Olfactory receptor 1258 1.48 NM_146794 Olfr1263 Olfactory receptor 1263 1.78 NM_146342 Olfr1269 Olfactory receptor 1269 1.51 NM_146985 Olfr1270 Olfactory receptor 1270 1.68 NM_146793 Olfr1271 Olfactory receptor 1271 1.49 NM_001011802 Olfr1318 Olfactory receptor 1318 1.42 NM_207240 Olfr1320 Olfactory receptor 1320 1.64 NM_207570 Olfr1328 Olfactory receptor 1328 1.49 NM_001011870 Olfr1329 Olfactory receptor 1329 1.44 NM_001011856 Olfr1331 Olfactory receptor 1331 1.46 NM_207157 Olfr1333 Olfactory receptor 1333 1.45 NM_146852 Olfr1339 Olfactory receptor 1339 1.46 NM_146283 Olfr1366 Olfactory receptor 1366 1.54 NM_146911 Olfr1377 Olfactory receptor 1377 1.69 NM_207573 Olfr1380 Olfactory receptor 1380 1.61 NM_001011790 Olfr1382 Olfactory receptor 1382 1.49 NM_146472 Olfr1384 Olfactory receptor 1384 1.48 NM_147065 Olfr1390 Olfactory receptor 1390 1.43 NM_146276 Olfr1394 Olfactory receptor 1394 1.47 NM_146275 Olfr1402 Olfactory receptor 1402 1.75 NM_146936 Olfr1417 Olfactory receptor 1417 1.51 NM_146410 Olfr1420 Olfactory receptor 1420 1.49 NM_001011853 Olfr1425 Olfactory receptor 1425 1.80 NM_001011839 Olfr1437 Olfactory receptor 1437 1.49 NM_146684 Olfr1440 Olfactory receptor 1440 1.41 NM_146701 Olfr1448 Olfactory receptor 1448 1.46 NM_001011832 Olfr1490 Olfactory receptor 1490 1.45 NM_001011831 Olfr1500 Olfactory receptor 1500 1.47

20 NM_013728 Olfr154 Olfactory receptor 154 1.48 NM_019474 Olfr156 Olfactory receptor 156 1.42 NM_019476 Olfr159 Olfactory receptor 159 1.45 NM_147068 Olfr166 Olfactory receptor 166 1.55 NM_147001 Olfr172 Olfactory receptor 172 1.52 NM_146994 Olfr201 Olfactory receptor 201 1.45 NM_146912 Olfr211 Olfactory receptor 211 1.42 NM_146446 Olfr215 Olfactory receptor 215 1.52 NM_001001809 Olfr218 Olfactory receptor 218 1.47 NM_146429 Olfr223 Olfactory receptor 223 1.42 NM_001001807 Olfr234 Olfactory receptor 234 1.60 NM_146269 Olfr247 Olfactory receptor 247 1.57 NM_146269 Olfr247 Olfactory receptor 247 1.57 NM_146783 Olfr26 Olfactory receptor 26 1.48 NM_146688 Olfr262 Olfactory receptor 262 1.42 NM_146858 Olfr275 Olfactory receptor 275 1.65 NM_001011752 Olfr293 Olfactory receptor 293 1.53 NM_001011828 Olfr304 Olfactory receptor 304 1.52 NM_146538 Olfr315 Olfactory receptor 315 1.47 NM_001011818 Olfr316 Olfactory receptor 316 1.43 NM_207230 Olfr318 Olfactory receptor 318 1.47 NM_207153 Olfr325 Olfactory receptor 325 1.74 NM_146502 Olfr328 Olfactory receptor 328 1.67 NM_001011531 Olfr329 Olfactory receptor 329 1.72 NM_001011861 Olfr331 Olfactory receptor 331 1.50 NM_146942 Olfr351 Olfactory receptor 351 1.57 NM_146941 Olfr353 Olfactory receptor 353 1.43 NM_146625 Olfr355 Olfactory receptor 355 1.48 NM_146622 Olfr360 Olfactory receptor 360 1.63 NM_146270 Olfr370 Olfactory receptor 370 1.47 NM_147023 Olfr385 Olfactory receptor 385 1.54 NM_146710 Olfr398 Olfactory receptor 398 1.64 NM_001011863 Olfr406 Olfactory receptor 406 1.67 NM_146715 Olfr419 Olfactory receptor 419 1.43 NM_010984 Olfr42 Olfactory receptor 42 1.51 NM_146721 Olfr424 Olfactory receptor 424 1.63 NM_146711 Olfr43 Olfactory receptor 43 1.57 NM_146718 Olfr430 Olfactory receptor 430 1.44 NM_146716 Olfr432 Olfactory receptor 432 1.95 NM_146717 Olfr433 Olfactory receptor 433 2.16 NM_146295 Olfr446 Olfactory receptor 446 1.52 NM_147064 Olfr449 Olfactory receptor 449 1.42 NM_146445 Olfr450 Olfactory receptor 450 1.48 NM_001011869 Olfr452 Olfactory receptor 452 1.46 NM_001011528 Olfr456 Olfactory receptor 456 1.48 NM_146987 Olfr457 Olfactory receptor 457 1.60 NM_146444 Olfr458 Olfactory receptor 458 1.43 NM_010990 Olfr48 Olfactory receptor 48 1.42 NM_146735 Olfr483 Olfactory receptor 483 1.41 NM_146773 Olfr508 Olfactory receptor 508 1.49 NM_146723 Olfr513 Olfactory receptor 513 1.41 NM_146956 Olfr525 Olfactory receptor 525 1.54 NM_001011776 Olfr527 Olfactory receptor 527 1.60 NM_146519 Olfr530 Olfactory receptor 530 1.45 NM_001011815 Olfr533 Olfactory receptor 533 1.65 NM_146954 Olfr535 Olfactory receptor 535 1.67 NM_146520 Olfr536 Olfactory receptor 536 1.53 NM_146962 Olfr541 Olfactory receptor 541 1.53 NM_147079 Olfr547 Olfactory receptor 547 1.58 NM_147101 Olfr549 Olfactory receptor 549 1.55 NM_147104 Olfr550 Olfactory receptor 550 1.63 NM_147113 Olfr560 Olfactory receptor 560 1.52 NM_147091 Olfr568 Olfactory receptor 568 1.44 NM_147088 Olfr569 Olfactory receptor 569 1.52

21 NM_147041 Olfr57 Olfactory receptor 57 1.41 NM_146360 Olfr574 Olfactory receptor 574 1.76 NM_147109 Olfr577 Olfactory receptor 577 1.41 NM_147115 Olfr578 Olfactory receptor 578 1.56 NM_147054 Olfr584 Olfactory receptor 584 1.44 NM_011002 Olfr59 Olfactory receptor 59 1.57 NM_207143 Olfr594 Olfactory receptor 594 1.47 NM_147080 Olfr615 Olfactory receptor 615 1.44 NM_146315 Olfr62 Olfactory receptor 62 1.55 NM_001011865 Olfr624 Olfactory receptor 624 1.60 NM_147119 Olfr632 Olfactory receptor 632 1.45 NM_146379 Olfr654 Olfactory receptor 654 1.53 NM_146820 Olfr655 Olfactory receptor 655 1.81 NM_147050 Olfr659 Olfactory receptor 659 1.42 NM_146748 Olfr661 Olfactory receptor 661 1.66 NM_001011757 Olfr663 Olfactory receptor 663 1.51 NM_147096 Olfr666 Olfactory receptor 666 1.43 NM_147060 Olfr667 Olfactory receptor 667 1.59 NM_147059 Olfr668 Olfactory receptor 668 1.44 NM_146758 Olfr678 Olfactory receptor 678 1.44 NM_020290 Olfr690 Olfactory receptor 690 1.48 NM_147061 Olfr691 Olfactory receptor 691 1.46 NM_146355 Olfr692 Olfactory receptor 692 1.48 NM_001011542 Olfr708 Olfactory receptor 708 1.44 NM_146493 Olfr730 Olfactory receptor 730 1.54 NM_146668 Olfr739 Olfactory receptor 739 1.51 NM_001011829 Olfr761 Olfactory receptor 761 1.44 NM_207008 Olfr773-ps1 Olfactory receptor 773, 1 1.52 NM_001011797 Olfr782 Olfactory receptor 782 1.49 NM_146729 Olfr784 Olfactory receptor 784 1.41 NM_146931 Olfr796 Olfactory receptor 796 1.74 NM_146559 Olfr868 Olfactory receptor 868 1.47 NM_146375 Olfr918 Olfactory receptor 918 1.54 NM_146782 Olfr921 Olfactory receptor 921 1.58 NM_001011813 Olfr93 Olfactory receptor 93 1.41 NM_146507 Olfr944 Olfactory receptor 944 1.69 NM_146330 Olfr958 Olfactory receptor 958 1.49 NM_001011826 Olfr967 Olfactory receptor 967 1.49 NM_146828 Olfr975 Olfactory receptor 975 1.74 NM_146367 Olfr976 Olfactory receptor 976 1.49 NM_146608 Olfr984 Olfactory receptor 984 1.53 NM_146435 Olfr993 Olfactory receptor 993 1.56 NM_178657 Oog1 Oogenesin 1 1.65 NM_201258 Oog3 Oogenesin 3 1.46 NM_153122 Oplah 5-oxoprolinase (ATP-hydrolysing) 1.41 NM_011012 Oprl1 receptor-like 1 1.42 NM_008768 Orm1 Orosomucoid 1 1.48 NM_001013365 Osm 1.73 NM_001013759 OTTMUSG00000000934 Predicted gene, OTTMUSG00000000934 1.47 NM_001007584 OTTMUSG00000002038 Predicted gene, OTTMUSG00000002038 1.53 NM_177571 OTTMUSG00000010433 Predicted gene, OTTMUSG00000010433 1.46 NM_001034900 OTTMUSG00000015743 Predicted gene, OTTMUSG00000015743 1.57 NM_001025574 OTTMUSG00000015915 Predicted gene, OTTMUSG00000015915 1.53 NM_007696 Ovgp1 Oviductal glycoprotein 1 1.44 NM_001001490 Oxgr1 Oxoglutarate (alpha-ketoglutarate) receptor 1 1.65 NM_011033 Pabpc2 Poly A binding protein, cytoplasmic 2 1.43 NM_053182 Pag1 associated with glycosphingolipid microdomains 1 1.42 NM_172868 Palm2 Paralemmin 2 1.57 NM_177460 Parp16 Poly (ADP-) polymerase family, member 16 1.42 NM_172272 Pars2 Prolyl-tRNA synthetase (mitochondrial)(putative) 1.70 NM_020606 Parva Parvin, alpha 1.66 NM_029508 Pcgf5 Polycomb group ring finger 5 1.46 NM_011044 Pck1 Phosphoenolpyruvate carboxykinase 1, cytosolic 1.56 NM_008791 Pcp4 Purkinje cell protein 4 1.46

22 NM_013628 Pcsk1 Proprotein convertase subtilisin/kexin type 1 1.42 NM_008797 Pcx Pyruvate carboxylase 1.44 NM_008798 Pdcd1 Programmed cell death 1 1.44 NM_016688 Pdcd7 Programmed cell death protein 7 1.71 NM_153422 Pde5a Phosphodiesterase 5A, cGMP-specific 1.61 NM_008806 Pde6b Phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide 1.45 NM_033614 Pde6c Phosphodiesterase 6C, cGMP specific, cone, alpha prime 1.51 NM_172263 Pde8b Phosphodiesterase 8B 1.60 NM_008811 Pdha2 Pyruvate dehydrogenase E1 alpha 2 1.56 NM_001033222 Pdzd8 PDZ domain containing 8 1.50 NM_011868 Peci Peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase 1.53 NM_008819 Pemt Phosphatidylethanolamine N-methyltransferase 1.49 NM_008822 Pex7 Peroxisome biogenesis factor 7 1.67 NM_031190 Pgk2 2 1.42 NM_207263 Pglyrp4 Peptidoglycan recognition protein 4 1.60 NM_008829 Pgr 1.49 NM_172603 Phf11 PHD finger protein 11 1.50 NM_053191 Pi15 Peptidase inhibitor 15 1.60 NM_201406 Pigs Phosphatidylinositol glycan anchor biosynthesis, class S 1.44 NM_011084 Pik3c2g Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide 1.66 NM_178149 Pik3ip1 Phosphoinositide-3-kinase interacting protein 1 1.51 NM_011087 Pira1 Paired-Ig-like receptor A1 1.42 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 1.45 NM_029686 Pkd1l2 Polycystic kidney disease 1 like 2 1.43 NM_001029838 Pknox2 Pbx/knotted 1 homeobox 2 1.67 NM_011107 Pla2g1b A2, group IB, pancreas 1.50 NM_008867 Pla2r1 receptor 1 1.44 NM_148937 Plcd4 , delta 4 1.57 NM_178911 Pld4 family, member 4 1.49 Pleckstrin domain containing, family A (phosphoinositide binding specific) NM_133942 Plekha1 member 1 1.42 Pleckstrin homology domain containing, family A (phosphoinositide binding specific) NM_001001335 Plekha8 member 8 1.54 NM_008880 Plscr2 scramblase 2 1.45 NM_001030305 Pmp2 Peripheral protein 2 1.56 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 1.64 NM_011128 Pnliprp2 Pancreatic lipase-related protein 2 1.44 NM_011136 Pou2af1 POU domain, class 2, associating factor 1 1.45 NM_015817 Ppap2c Phosphatidic type 2c 1.57 NM_028922 Ppapdc2 Phosphatidic acid phosphatase type 2 domain containing 2 1.45 NM_134084 Ppif Peptidylprolyl isomerase F (cyclophilin F) 1.59 NM_008014 Ppm1g 1G (formerly 2C), -dependent, gamma isoform 1.59 NM_138605 Ppp1r3f Protein phosphatase 1, regulatory (inhibitor) subunit 3F 1.47 NM_198168 Ppp2r5b , regulatory subunit B (B56), beta isoform 1.41 NM_031390 Pramel3 Preferentially expressed antigen in melanoma-like 3 1.62 NM_033573 Prcc Papillary (translocation-associated) 1.44 NM_027504 Prdm16 PR domain containing 16 1.49 NM_027547 Prdm5 PR domain containing 5 1.54 NM_016703 Preb Prolactin regulatory element binding 1.68 NM_011073 Prf1 Perforin 1 (pore forming protein) 1.56 NM_008925 Prkcsh substrate 80K-H 1.43 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 1.56 NM_008865 Prl3b1 Prolactin family 3, subfamily b, member 1 1.44 NM_011165 Prl4a1 Prolactin family 4, subfamily a, member 1 1.59 NM_026206 Prl7c1 Prolactin family 7, subfamily c, member 1 1.43 NM_011170 Prnp Prion protein 1.50 NM_008936 Prop1 Paired like homeodomain factor 1 1.76 NM_028447 Prrc1 -rich coiled-coil 1 1.57 NM_009430 Prss2 , serine, 2 1.81 NM_133351 Prss8 Protease, serine, 8 (prostasin) 1.56 NM_175249 Psapl1 Prosaposin-like 1 1.57 NM_028195 Pscd4 Pleckstrin homology, Sec7 and coiled/coil domains 4 1.61 NM_144889 Psmf1 (prosome, macropain) inhibitor subunit 1 1.55 NM_008965 Ptger4 Prostaglandin E receptor 4 (subtype EP4) 1.45 NM_008973 Ptn Pleiotrophin 1.43

23 NM_011215 Ptprn2 Protein tyrosine phosphatase, receptor type, N polypeptide 2 1.48 NM_178595 Ptrh1 Peptidyl-tRNA 1 homolog (S. cerevisiae) 1.56 NM_030723 Pum2 Pumilio 2 (Drosophila) 1.44 NM_152821 Purg Purine-rich element binding protein G 1.42 NM_175562 Rab39 RAB39, member RAS oncogene family 1.42 NM_029391 Rab4b RAB4B, member RAS oncogene family 1.44 NM_009005 Rab7 RAB7, member RAS oncogene family 1.73 NM_011236 Rad52 RAD52 homolog (S. cerevisiae) 1.41 NM_009391 RAN, member RAS oncogene family 1.42 NM_033324 Ranbp1 RAN binding protein 1 1.41 NM_023579 Ranbp5 RAN binding protein 5 1.43 NM_001039086 Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 1.50 NM_009028 Rasl2-9 RAS-like, family 2, locus 9 1.44 NM_015754 Rbbp9 Retinoblastoma binding protein 9 1.71 NM_009034 Rbp2 Retinol binding protein 2, cellular 1.48 NM_022980 Rcan3 Regulator of 3 1.51 NM_138580 Rdbp RD RNA-binding protein 1.56 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 1.56 NM_175372 Rdh13 Retinol dehydrogenase 13 (all-trans and 9-cis) 1.47 NM_153133 Rdh9 Retinol dehydrogenase 9 1.43 NM_020509 Retnla Resistin like alpha 1.42 NM_023881 Retnlb Resistin like beta 1.42 NM_027266 Rg9mtd3 RNA (guanine-9-) methyltransferase domain containing 3 1.45 NM_015811 Rgs1 Regulator of G-protein signaling 1 1.49 NM_153171 Rgs13 Regulator of G-protein signaling 13 1.55 NM_029203 Rhox2 Reproductive homeobox 2 1.58 NM_001039688 Rhox4a Reproductive homeobox 4A 1.54 NM_021300 Rhox4b Reproductive homeobox 4B 1.75 NM_001039689 Rhox4c Reproductive homeobox 4C 1.62 NM_001039695 Rhox4d Reproductive homeobox 4D 1.60 NM_201236 Rhox4e Reproductive homeobox 4E 1.51 NM_001039696 Rhox4h Reproductive homeobox 4H 1.45 NM_001025086 Rhox7 Reproductive homeobox 7 1.43 NM_026611 Rnaset2b T2B 1.70 NM_026611 Rnaset2b Ribonuclease T2B 1.70 NM_153503 Rnf113a1 Ring finger protein 113A1 1.44 NM_026301 Rnf125 Ring finger protein 125 1.55 NM_153762 Rnf26 Ring finger protein 26 1.53 NM_021470 Rnf32 Ring finger protein 32 1.49 NM_011278 Rnf4 Ring finger protein 4 1.44 NM_181989 RP23-24J10.7 Retinal short chain dehydrogenase reductase 2 1.45 NM_172521 RP23-336F11.32 Nuclear protein in testis 1.74 NM_029548 Rph3al Rabphilin 3A-like (without C2 domains) 1.50 NM_001002239 Rpl17 Ribosomal protein L17 1.56 NM_009081 Rpl28 Ribosomal protein L28 1.44 NM_026594 Rpl39l Ribosomal protein L39-like 1.48 NM_009092 Rps17 Ribosomal protein S17 1.51 NM_013765 Rps26 Ribosomal protein S26 1.56 NM_026467 Rps27l Ribosomal protein S27-like 1.56 NM_009096 Rps6 1.60 NM_178775 Rps6kc1 Ribosomal protein S6 kinase polypeptide 1 1.57 NM_001001882 Rtel1 Regulator of telomere elongation helicase 1 1.52 NM_181817 Rxfp4 Relaxin family peptide receptor 4 1.46 NM_025393 S100a14 S100 calcium binding protein A14 1.47 NM_016882 Sart1 Squamous cell carcinoma antigen recognized by T-cells 1 1.43 NM_172205 Sbsn Suprabasin 1.71 NM_183216 Scd4 Stearoyl-coenzyme A desaturase 4 1.44 NM_178672 Scfd2 Sec1 family domain containing 2 1.48 NM_011681 Scgb1a1 Secretoglobin, family 1A, member 1 (uteroglobin) 1.71 NM_054037 Scgb3a1 Secretoglobin, family 3A, member 1 1.68 NM_011887 Scn11a Sodium channel, voltage-gated, type XI, alpha 1.47 NM_023912 Scyl1 SCY1-like 1 (S. cerevisiae) 1.52 NM_133704 Sec22a SEC22 vesicle trafficking protein-like A (S. cerevisiae) 1.53 NM_001029982 Sec23ip Sec23 interacting protein 1.45

24 NM_145373 Sectm1a Secreted and transmembrane 1A 1.53 NM_011347 Selp , 1.62 NM_011350 Sema4f Sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain 1.48 NM_199238 Sema6d Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.48 NM_029100 Sepn1 Selenoprotein N, 1 1.47 NM_009243 Serpina1a Serine (or cysteine) peptidase inhibitor, clade A, member 1a 1.43 NM_009244 Serpina1b Serine (or cysteine) preptidase inhibitor, clade A, member 1b 1.49 NM_009245 Serpina1c Serine (or cysteine) peptidase inhibitor, clade A, member 1c 1.55 NM_009246 Serpina1d Serine (or cysteine) peptidase inhibitor, clade A, member 1d 1.49 NM_009247 Serpina1e Serine (or cysteine) peptidase inhibitor, clade A, member 1e 1.44 NM_026687 Serpina1f Serine (or cysteine) peptidase inhibitor, clade A, member 1f 1.61 Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), NM_177920 Serpina7 member 7 1.52 NM_025867 Serpinb11 Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11 1.60 NM_173052 Serpinb1b Serine (or cysteine) peptidase inhibitor, clade B, member 1b 1.43 NM_080844 Serpinc1 Serine (or cysteine) peptidase inhibitor, clade C (), member 1 1.43 NM_021372 Sertad2 SERTA domain containing 2 1.52 NM_144792 Sgms1 synthase 1 1.60 NM_012009 Sh2d1b1 SH2 domain protein 1B1 1.48 NM_172788 Sh3md4 SH3 multiple domains 4 1.50 NM_019658 Shoc2 Soc-2 (suppressor of clear) homolog (C. elegans) 1.49 NM_023059 Sigirr Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 1.52 NM_022432 Sirt2 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) 1.45 NM_011543 Skp1a S-phase kinase-associated protein 1A 1.45 NM_144539 Slamf7 SLAM family member 7 1.47 NM_029612 Slamf9 SLAM family member 9 1.52 NM_030683 Slc14a2 Solute carrier family 14 ( transporter), member 2 1.52 NM_133895 Slc15a4 Solute carrier family 15, member 4 1.41 NM_177016 Slc17a4 Solute carrier family 17 (sodium phosphate), member 4 1.67 NM_030556 Slc19a3 Solute carrier family 19 (sodium/hydrogen exchanger), member 3 1.46 NM_011393 Slc1a2 Solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.67 NM_133980 Slc22a13 Solute carrier family 22 (organic cation transporter), member 13 1.53 NM_011395 Slc22a3 Solute carrier family 22 (organic cation transporter), member 3 1.41 NM_028048 Slc25a35 Solute carrier family 25, member 35 1.70 NM_138756 Slc25a36 Solute carrier family 25, member 36 1.58 NM_177243 Slc26a9 Solute carrier family 26, member 9 1.60 NM_178934 Slc2a12 Solute carrier family 2 (facilitated glucose transporter), member 12 1.57 NM_025286 Slc31a2 Solute carrier family 31, member 2 1.49 NM_011392 Slc34a1 Solute carrier family 34 (sodium phosphate), member 1 1.77 Solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), NM_144902 Slc35a3 member 3 1.71 NM_134060 Slc35b3 Solute carrier family 35, member B3 1.58 NM_001039676 Slc39a2 Solute carrier family 39 (zinc transporter), member 2 1.42 NM_009205 Slc3a1 Solute carrier family 3, member 1 1.49 NM_001037493 Slc41a3 Solute carrier family 41, member 3 1.46 NM_011403 Slc4a1 Solute carrier family 4 (anion exchanger), member 1 1.41 NM_001003915 Slc5a12 Solute carrier family 5 (sodium/glucose cotransporter), member 12 1.44 NM_201353 Slc6a7 Solute carrier family 6 ( transporter, L-proline), member 7 1.67 NM_016981 Slc9a1 Solute carrier family 9 (sodium/hydrogen exchanger), member 1 1.46 NM_033314 Slco2a1 Solute carrier organic anion transporter family, member 2a1 1.43 NM_175316 Slco2b1 Solute carrier organic anion transporter family, member 2b1 1.46 NM_032008 Slmap Sarcolemma associated protein 1.54 NM_025531 Slmo2 Slowmo homolog 2 (Drosophila) 1.44 NM_011414 Slpi Secretory leukocyte peptidase inhibitor 1.47 NM_028534 Smap1 Stromal membrane-associated protein 1 1.44 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily NM_007958 Smarcad1 a, containing DEAD/H box 1` 1.44 NM_211355 Smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 1.43 NM_007706 Socs2 Suppressor of cytokine signaling 2 1.41 NM_011366 Sorbs3 Sorbin and SH3 domain containing 3 1.42 NM_011436 Sorl1 Sortilin-related receptor, LDLR class A repeats-containing 1.42 NM_013673 Sp100 Nuclear antigen Sp100 1.51 NM_029599 Spag4l Sperm associated antigen 4-like 1.54 NM_001007463 Spag8 Sperm associated antigen 8 1.50 NM_028852 Spatc1 Spermatogenesis and centriole associated 1 1.77

25 NM_019866 Spib Spi-B transcription factor (Spi-1/PU.1 related) 1.52 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 1.62 NM_183284 Spink2 Serine peptidase inhibitor, Kazal type 2 1.55 NM_009258 Spink3 Serine peptidase inhibitor, Kazal type 3 1.48 NM_011468 Sprr2a Small proline-rich protein 2A 1.70 NM_011468 Sprr2a Small proline-rich protein 2A 1.70 NM_011472 Sprr2f Small proline-rich protein 2F 1.42 NM_011478 Sprr3 Small proline-rich protein 3 1.63 NM_173070 Sprr4 Small proline-rich protein 4 1.62 NM_020611 Srd5a2l 5 alpha-reductase 2-like 1.52 Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation NM_011481 Srms sites 1.43 NM_025965 Ssr1 Signal sequence receptor, alpha 1.42 NM_009283 Stat1 Signal transducer and activator of transcription 1 1.56 NM_030201 Stch Stress 70 protein , microsome-associated, human homolog 1.76 NM_011494 Stk16 Serine/threonine kinase 16 1.44 NM_021302 Stk32c Serine/threonine kinase 32C 1.64 NM_172734 Stk38l Serine/threonine kinase 38 like 1.48 NM_009292 Stra8 Stimulated by retinoic acid gene 8 1.46 NM_007941 Stx2 2 1.57 NM_026474 Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 1.72 NM_023135 Sult1e1 Sulfotransferase family 1E, member 1 1.61 NM_144871 Suv420h1 Suppressor of variegation 4-20 homolog 1 (Drosophila) 1.49 NM_001003952 Sval3 Seminal vesicle antigen-like 3 1.44 NM_172804 Syt16 XVI 1.46 NM_001040086 Sytl2 Synaptotagmin-like 2 1.42 NM_145133 T2bp Traf2 binding protein 1.41 NM_053205 Taar1 Trace -associated receptor 1 1.56 NM_145968 Tagap T-cell activation Rho GTPase-activating protein 1.41 NM_033074 Tars Threonyl-tRNA synthetase 1.45 NM_207021 Tas2r117 Taste receptor, type 2, member 117 2.38 NM_020503 Tas2r119 Taste receptor, type 2, member 119 1.63 NM_207028 Tas2r126 Taste receptor, type 2, member 126 1.76 NM_199158 Tas2r134 Taste receptor, type 2, member 134 1.48 NM_199159 Tas2r135 Taste receptor, type 2, member 135 1.56 NM_001001452 Tas2r143 Taste receptor, type 2, member 143 1.52 NM_013773 Tcl1b1 T-cell leukemia/lymphoma 1B, 1 1.49 NM_011553 Tcp10b T-complex protein 10b 1.54 NM_009341 Tcp10c T-complex protein 10c 1.46 NM_009347 Tecta Tectorin alpha 1.41 NM_153099 Tessp2 Testis 2 1.47 NM_009363 Tff2 Trefoil factor 2 (spasmolytic protein 1) 1.70 NM_018783 Tfip11 Tuftelin interacting protein 11 1.44 NM_009375 Tg Thyroglobulin 1.52 NM_028799 Tgm5 5 1.44 NM_177726 Tgm6 Transglutaminase 6 1.73 NM_025416 Them5 superfamily member 5 1.47 NM_028597 Thoc3 THO complex 3 1.61 NM_146153 Thrap3 associated protein 3 1.44 NM_013899 Timm10 of inner mitochondrial membrane 10 homolog (yeast) 1.42 NM_172476 Tmc7 Transmembrane channel-like gene family 7 1.47 NM_025458 Tmed6 Transmembrane emp24 protein transport domain containing 6 1.66 NM_001033475 Tmed8 Transmembrane emp24 domain containing 8 1.58 NM_026433 Tmem100 Transmembrane protein 100 1.44 NM_177735 Tmem130 Transmembrane protein 130 1.52 NM_018872 Tmem131 Transmembrane protein 131 1.44 NM_145597 Tmem161a Transmembrane protein 161A 1.60 NM_153589 Tmem16b Transmembrane protein 16B 1.48 NM_153596 Tmem17 Transmembrane protein 17 1.46 NM_026516 Tmem178 Transmembrane protein 178 1.42 NM_178915 Tmem179 Transmembrane protein 179 1.43 NM_172049 Tmem18 Transmembrane protein 18 1.45 NM_172608 Tmem184b Transmembrane protein 184b 1.43 NM_027865 Tmem25 Transmembrane protein 25 1.48

26 NM_144805 Tmem40 Transmembrane protein 40 1.68 NM_025693 Tmem41a Transmembrane protein 41a 1.59 NM_133706 Tmem97 Transmembrane protein 97 1.53 NM_001030297 Tmprss11c Transmembrane protease, serine 11c 1.48 NM_013749 Tnfrsf12a receptor superfamily, member 12a 1.54 NM_178931 Tnfrsf14 Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 1.51 NM_009403 Tnfsf8 Tumor necrosis factor (ligand) superfamily, member 8 1.42 NM_139064 Tnip2 TNFAIP3 interacting protein 2 1.49 NM_031880 Tnk1 , non-receptor, 1 1.55 NM_011619 Tnnt2 T2, cardiac 1.41 NM_009407 Tnp1 Transition protein 1 1.52 NM_031176 Tnxb Tenascin XB 1.55 NM_023764 Tollip Toll interacting protein 1.48 NM_133673 Tor1b Torsin family 1, member B 1.42 NM_026429 Tpbpb Trophoblast specific protein beta 1.43 NM_001024206 Trappc1 Trafficking protein particle complex 1 1.44 NM_001025599 Trim26 Tripartite motif protein 26 1.48 NM_053170 Trim33 Tripartite motif protein 33 1.41 NM_134252 Trpm8 Transient receptor potential cation channel, subfamily M, member 8 1.43 NM_001007572 Trpv5 Transient receptor potential cation channel, subfamily V, member 5 1.63 NM_199033 Tsen2 TRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) 1.50 NM_016909 Tsnax Translin-associated 1.43 NM_019634 Tspan7 7 1.63 NM_011652 Ttn 1.42 NM_009450 Tubb2a , beta 2a 1.44 NM_153519 Txndc2 Thioredoxin domain containing 2 (spermatozoa) 1.53 NM_175646 Txnl4b Thioredoxin-like 4B 1.72 NM_011662 Tyrobp TYRO protein tyrosine kinase binding protein 1.47 NM_001012392 U46068 CDNA sequence U46068 1.48 NM_177823 Ubash3a associated and SH3 domain containing, A 1.65 NM_025985 Ube2g1 Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 1.50 NM_019949 Ube2l6 Ubiquitin-conjugating enzyme E2L 6 1.46 NM_198623 Ubqln3 Ubiquilin 3 1.78 NM_198624 Ubqlnl Ubiquilin-like 1.58 NM_016723 Uchl3 Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 1.45 NM_009464 Ucp3 Uncoupling protein 3 (mitochondrial, proton carrier) 1.42 NM_145079 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 1.52 NM_009472 Unc5c Unc-5 homolog C (C. elegans) 1.45 NM_029692 Upp2 Uridine 2 1.46 NM_146144 Usp1 Ubiquitin specific peptdiase 1 1.43 NM_001004143 Usp22 Ubiquitin specific peptidase 22 1.50 NM_133857 Usp53 Ubiquitin specific peptidase 53 1.47 NM_011682 Utrn Utrophin 1.42 NM_053218 V1ra3 Vomeronasal 1 receptor, A3 1.57 NM_053221 V1ra6 Vomeronasal 1 receptor, A6 1.50 NM_134166 V1rc11 Vomeronasal 1 receptor, C11 1.47 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 1.46 NM_134172 V1rc17 Vomeronasal 1 receptor, C17 1.42 NM_134183 V1rc28 Vomeronasal 1 receptor, C28 1.50 NM_030741 V1rd2 Vomeronasal 1 receptor, D2 1.51 NM_030739 V1rd4 Vomeronasal 1 receptor, D4 1.47 NM_134209 V1rg8 Vomeronasal 1 receptor, G8 1.52 NM_009502 Vcl Vinculin 1.63 NM_011704 Vnn1 Vanin 1 1.53 NM_016983 Vpreb2 Pre-B lymphocyte gene 2 1.46 NM_030559 Vps16 16 (yeast) 1.72 NM_019780 Vps29 Vacuolar protein sorting 29 (S. pombe) 1.55 NM_172120 Vps41 Vacuolar protein sorting 41 (yeast) 1.46 NM_001029843 Vrk1 Vaccinia related kinase 1 1.44 NM_011709 Wap Whey acidic protein 1.61 NM_153391 Wdr19 WD repeat domain 19 1.50 NM_027614 Wdr20b WD repeat domain 20b 1.44 NM_172864 Wdr63 WD repeat domain 63 1.45 NM_026044 Wdr85 WD40 repeat domain 85 1.44

27 NM_138685 Wfdc15b WAP four-disulfide core domain 15B 1.45 NM_197940 Wipf2 WAS/WASL interacting , member 2 1.44 NM_021365 Xlr4b X-linked lymphocyte-regulated 4B 1.44 NM_009532 Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.56 NM_026570 Yeats4 YEATS domain containing 4 1.51 NM_145550 Yipf1 Yip1 domain family, member 1 1.46 NM_023784 Yipf7 Yip1 domain family, member 7 1.45 NM_027476 Zdhhc24 , DHHC domain containing 24 1.56 NM_030708 Zfhx4 Zinc finger homeodomain 4 1.46 NM_018791 Zfp108 Zinc finger protein 108 1.47 NM_145483 Zfp160 Zinc finger protein 160 1.42 NM_148924 Zfp263 Zinc finger protein 263 1.44 NM_175428 Zfp295 Zinc finger protein 295 1.58 NM_199304 Zfp341 Zinc finger protein 341 1.62 NM_001009549 Zfp36l3 Zinc finger protein 36, C3H type-like 3 1.48 NM_175558 Zfp446 Zinc finger protein 446 1.41 NM_181326 Zfp521 Zinc finger protein 521 1.41 NM_183149 Zfp598 Zinc finger protein 598 1.42 NM_009564 Zfp64 Zinc finger protein 64 1.50 NM_001012325 Zfp708 Zinc finger protein 708 1.46 NM_027264 Zfp715 Zinc finger protein 715 1.45 NM_146185 Zfp790 Zinc finger protein 790 1.47 NM_028913 Zfp819 Zinc finger protein 819 1.56 NM_001001130 Zfp85-rs1 Zinc finger protein 85, related sequence 1 1.66 NM_011483 Znrf4 Zinc and ring finger 4 1.41 NM_027061 Zpbp2 Zona pellucida binding protein 2 1.59 NM_178375 Zswim3 Zinc finger, SWIM domain containing 3 1.43 NM_030260 Zxdc ZXD family zinc finger C 1.60 NM_001001987 1.45 NM_001002772 1.74 NM_001002794 1.55 NM_001013752 1.59 NM_001013781 1.68 NM_001014396 1.61 NM_001024470 1.78 NM_001024724 1.42 NM_001025564 1.44 NM_001033195 1.92 NM_001033401 1.46 NM_001033798 1.43 NM_001033814 1.50 NM_001037750 1.57 NM_001039041 1.48 NM_001039148 1.46 NM_001039193 1.53 NM_001040201 1.44 NM_008835 1.42 NM_011853 1.41 NM_016664 1.55 NM_020609 1.47 NM_025743 1.54 NM_025766 1.53 NM_026059 1.55 NM_026230 1.54 NM_026287 1.48 NM_026461 1.53 NM_027923 1.44 NM_028045 1.46 NM_028318 1.41 NM_028842 1.42 NM_030107 1.45 NM_133695 1.43 NM_146163 1.47 NM_153199 1.50

28 NM_172418 1.47 NM_172483 1.52 NM_172740 1.44 NM_175330 1.42 NM_175545 1.44 NM_176991 1.58 NM_176992 1.53 NM_177011 1.46 NM_177012 1.42 NM_177052 1.45 NM_177057 1.58 NM_177179 1.53 NM_177202 1.56 NM_177288 1.42 NM_177895 1.48 NM_183107 1.55 NM_183108 1.57 NM_183120 1.43 NM_183215 1.49 NM_207528 1.50

SUPPLEMENTAL TABLE S2: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat Model (p<0.001)

Accession Number Symbol Name Fold Change NM_027669 12-Sep Septin 12 0.58 NM_024179 0610009O20Rik RIKEN cDNA 0610009O20 gene 0.69 NM_029090 1200013P24Rik RIKEN cDNA 1200013P24 gene 0.64 NM_026894 1500001M20Rik RIKEN cDNA 1500001M20 gene 0.60 NM_026451 1600012H06Rik RIKEN cDNA 1600012H06 gene 0.62 NM_025851 1700010I14Rik RIKEN cDNA 1700010I14 gene 0.70 NM_001017407 1700021K02Rik RIKEN cDNA 1700021K02 gene 0.70 NM_025585 1700029F12Rik RIKEN cDNA 1700029F12 gene 0.55 NM_028528 1700058C13Rik RIKEN cDNA 1700058C13 gene 0.57 NM_026099 1700065I17Rik RIKEN cDNA 1700065I17 gene 0.72 NM_029714 1700067C01Rik RIKEN cDNA 1700067C01 gene 0.65 NM_001033185 1700084C01Rik RIKEN cDNA 1700084C01 gene 0.70 NM_026947 1810022C23Rik RIKEN cDNA 1810022C23 gene 0.71 NM_025465 1810029B16Rik RIKEN cDNA 1810029B16 gene 0.72 NM_029733 2010005H15Rik RIKEN cDNA 2010005H15 gene 0.70 NM_172919 2210010B09Rik RIKEN cDNA 2210010B09 gene 0.67 NM_175391 2210421G13Rik RIKEN cDNA 2210421G13 gene 0.70 NM_175148 2300002M23Rik RIKEN cDNA 2300002M23 gene 0.61 NM_027087 2300006N05Rik RIKEN cDNA 2300006N05 gene 0.66 NM_027087 2300006N05Rik RIKEN cDNA 2300006N05 gene 0.66 NM_029609 2310007H09Rik RIKEN cDNA 2310007H09 gene 0.71 NM_024210 2310033P09Rik RIKEN cDNA 2310033P09 gene 0.68 NM_183119 2410141K09Rik RIKEN cDNA 2410141K09 gene 0.72 NM_026455 2510049I19Rik RIKEN cDNA 2510049I19 gene 0.71 NM_183220 2610203E10Rik RIKEN cDNA 2610203E10 gene 0.56 NM_145078 2610305D13Rik RIKEN cDNA 2610305D13 gene 0.60 NM_025599 2610528E23Rik RIKEN cDNA 2610528E23 gene 0.59 NM_175184 2610528K11Rik RIKEN cDNA 2610528K11 gene 0.70 NM_026529 2700062C07Rik RIKEN cDNA 2700062C07 gene 0.69 NM_027279 2810422O20Rik RIKEN cDNA 2810422O20 gene 0.68 NM_133703 2810453I06Rik RIKEN cDNA 2810453I06 gene 0.67 NM_026054 2810474O19Rik RIKEN cDNA 2810474O19 gene 0.72 NM_026543 3010026O09Rik RIKEN cDNA 3010026O09 gene 0.70 NM_027510 3830403N18Rik RIKEN cDNA 3830403N18 gene 0.52 NM_172753 4732435N03Rik RIKEN cDNA 4732435N03 gene 0.70 NM_027568 4733401H21Rik RIKEN cDNA 4733401H21 gene 0.67 NM_001037743 4921506M07Rik RIKEN cDNA 4921506M07 gene 0.67

29 NM_028671 4930432H15Rik RIKEN cDNA 4930432H15 gene 0.71 NM_207248 4930433I11Rik RIKEN cDNA 4930433I11 gene 0.61 NM_029440 4930434E21Rik RIKEN cDNA 4930434E21 gene 0.71 NM_029131 4930503E14Rik RIKEN cDNA 4930503E14 gene 0.69 NM_029199 4930542N07Rik RIKEN cDNA 4930542N07 gene 0.63 NM_175393 4930555G01Rik RIKEN cDNA 4930555G01 gene 0.73 NM_177230 4932413O14Rik RIKEN cDNA 4932413O14 gene 0.67 NM_177599 4932415M13Rik RIKEN cDNA 4932415M13 gene 0.70 NM_177901 4933402J07Rik RIKEN cDNA 4933402J07 gene 0.70 NM_025747 4933411K20Rik RIKEN cDNA 4933411K20 gene 0.64 NM_025750 4933417A18Rik RIKEN cDNA 4933417A18 gene 0.58 NM_027500 4933434E20Rik RIKEN cDNA 4933434E20 gene 0.68 NM_001029993 5830416A07Rik RIKEN cDNA 5830416A07 gene 0.69 NM_178801 6030446N20Rik RIKEN cDNA 6030446N20 gene 0.72 NM_173400 6230416J20Rik RIKEN cDNA 6230416J20 gene 0.59 NM_026377 6330577E15Rik RIKEN cDNA 6330577E15 gene 0.73 NM_001039552 9030025P20Rik RIKEN cDNA 9030025P20 gene 0.69 NM_001039493 9430067K14Rik RIKEN cDNA 9430067K14 gene 0.73 NM_183194 9930109F21Rik RIKEN cDNA 9930109F21 gene 0.72 NM_177358 A630033E08Rik RIKEN cDNA A630033E08 gene 0.62 NM_013454 Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.66 NM_019875 Abcb9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 0.65 NM_009593 Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 0.56 NM_030239 Abcg3 ATP-binding cassette, sub-family G (WHITE), member 3 0.72 NM_001033041 Acmsd Amino carboxymuconate semialdehyde decarboxylase 0.72 NM_145444 Acot5 Acyl-CoA thioesterase 5 0.69 NM_033268 Actn2 Actinin alpha 2 0.71 NM_028514 Actrt1 Actin-related protein T1 0.68 NM_020330 Adam21 A disintegrin and metallopeptidase domain 21 0.70 NM_175236 Adhfe1 dehydrogenase, iron containing, 1 0.64 NM_013461 Adra1a , alpha 1a 0.65 NM_033565 Aff4 AF4/FMR2 family, member 4 0.72 NM_054070 Afg3l1 AFG3(ATPase family gene 3)-like 1 (yeast) 0.67 NM_175086 Agtr1b II receptor, type 1b 0.61 NM_133818 AI597479 Expressed sequence AI597479 0.71 NM_177912 AI987692 Expressed sequence AI987692 0.72 NM_019467 Aif1 Allograft inflammatory factor 1 0.66 NM_001013779 Aim2 Absent in melanoma 2 0.67 NM_001033966 Ak2 2 0.72 NM_031185 Akap12 A kinase (PRKA) anchor protein (gravin) 12 0.70 NM_134072 Akr1c14 Aldo-keto reductase family 1, member C14 0.66 NM_008525 Alad Aminolevulinate, delta-, dehydratase 0.72 NM_020559 Alas1 Aminolevulinic acid synthase 1 0.69 NM_001033303 Ampd1 Adenosine monophosphate deaminase 1 (isoform M) 0.65 NM_007446 Amy1 Amylase 1, salivary 0.66 NM_177544 Ang4 , ribonuclease A family, member 4 0.65 NM_170729 Ank3 Ankyrin 3, epithelial 0.71 NM_009671 Ankfy1 Ankyrin repeat and FYVE domain containing 1 0.72 NM_054041 Antxr1 Anthrax toxin receptor 1 0.71 NM_007460 Ap3d1 Adaptor-related protein complex 3, delta 1 subunit 0.69 NM_029505 Ap3m2 Adaptor-related protein complex 3, mu 2 subunit 0.70 NM_007474 Aqp8 Aquaporin 8 0.69 NM_019689 Arid3b AT rich interactive domain 3B (Bright like) 0.72 NM_178050 Arl6ip2 ADP-ribosylation factor-like 6 interacting protein 2 0.72 NM_022989 Arl6ip6 ADP-ribosylation factor-like 6 interacting protein 6 0.70 NM_026034 Armc10 Armadillo repeat containing 10 0.68 NM_021548 Arpp19 CAMP-regulated phosphoprotein 19 0.70 NM_009713 Arsa A 0.72 NM_019734 Asah1 N-acylsphingosine amidohydrolase 1 0.71 NM_080847 Asb15 Ankyrin repeat and SOCS box-containing protein 15 0.67 NM_023048 Asb4 Ankyrin repeat and SOCS box-containing protein 4 0.66 NM_026402 Atg3 Autophagy-related 3 (yeast) 0.72 NM_144900 Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.72 NM_026094 Atp8b3 ATPase, Class I, type 8B, member 3 0.72

30 NM_001033197 AU015228 Expressed sequence AU015228 0.59 NM_001033220 AU021092 Expressed sequence AU021092 0.65 NM_199313 AY053573 CDNA sequence AY053573 0.61 NM_194347 AY358078 CDNA sequence AY358078 0.65 NM_001018019 AY616753 CDNA sequence, AY616753 0.69 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene 0.54 NM_016888 B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 0.72 NM_177303 B430119L13Rik RIKEN cDNA B430119L13 gene 0.70 NM_153539 B830045N13Rik RIKEN cDNA B830045N13 gene 0.73 NM_026116 Bbs2 Bardet-Biedl syndrome 2 homolog (human) 0.72 NM_145397 BC002059 CDNA sequence BC002059 0.73 NM_145497 BC016495 CDNA sequence BC016495 0.68 NM_145577 BC023179 CDNA sequence BC023179 0.70 NM_181420 BC032265 CDNA sequence BC032265 0.71 NM_001024645 BC036313 CDNA sequence BC036313 0.62 NM_175020 BC048599 CDNA sequence BC048599 0.70 NM_199150 BC049730 CDNA sequence BC049730 0.62 NM_172513 BC049806 CDNA sequence BC049806 0.70 NM_181419 BC050092 CDNA sequence BC050092 0.72 NM_001013773 BC055004 CDNA sequence BC055004 0.62 NM_001024848 BC085284 CDNA sequence BC085284 0.72 NM_026602 Bcas2 Breast carcinoma amplified sequence 2 0.59 NM_031368 Bglap-rs1 Bone gamma-carboxyglutamate protein, related sequence 1 0.58 NM_007566 Birc6 Baculoviral IAP repeat-containing 6 0.70 NM_177772 Bpil2 Bactericidal/permeability-increasing protein-like 2 0.68 NM_009765 Brca2 2 0.70 NM_009763 Bst1 Bone marrow stromal cell antigen 1 0.70 NM_198095 Bst2 Bone marrow stromal cell antigen 2 0.70 NM_178245 Bsx Brain specific homeobox 0.69 NM_172618 Btbd9 BTB (POZ) domain containing 9 0.71 NM_145455 Btf3 Basic transcription factor 3 0.73 NM_027292 Bzrpl1 Benzodiazapine receptor, peripheral-like 1 0.72 NM_177110 C130023O10Rik RIKEN cDNA C130023O10 gene 0.72 NM_177110 C130023O10Rik RIKEN cDNA C130023O10 gene 0.72 NM_177818 C130057D23Rik RIKEN cDNA C130057D23 gene 0.72 NM_153155 C1ql3 C1q-like 3 0.70 NM_172616 C330027C09Rik RIKEN cDNA C330027C09 gene 0.66 NM_009779 C3ar1 Complement component 3a receptor 1 0.67 NM_198017 C430003P19Rik RIKEN cDNA C430003P19 gene 0.71 NM_009286 C730007P19Rik RIKEN cDNA C730007P19 gene 0.71 NM_145368 C730036D15Rik RIKEN cDNA C730036D15 gene 0.72 NM_177002 C730048C13Rik RIKEN cDNA C730048C13 gene 0.70 NM_026908 Cab39l Calcium binding protein 39-like 0.72 NM_013732 Cartpt CART prepropeptide 0.61 NM_172914 Ccdc113 Coiled-coil domain containing 113 0.73 NM_001033243 Ccdc114 Coiled-coil domain containing 114 0.60 NM_001033654 Ccdc139 Coiled-coil domain containing 139 0.72 NM_001033455 Ccdc27 Coiled-coil domain containing 27 0.70 NM_011338 Ccl9 Chemokine (C-C motif) ligand 9 0.67 NM_010761 Ccndbp1 Cyclin D-type binding-protein 1 0.70 NM_023243 Ccnh Cyclin H 0.72 NM_017367 Ccni Cyclin I 0.66 NM_009912 Ccr1 Chemokine (C-C motif) receptor 1 0.63 NM_009838 Cct6a Chaperonin subunit 6a (zeta) 0.67 NM_026862 Cd177 CD177 antigen 0.63 NM_133238 Cd209a CD209a antigen 0.61 NM_009847 Cd2ap CD2-associated protein 0.64 NM_009860 Cdc25c Cell division cycle 25 homolog C (S. pombe) 0.67 NM_009861 Cdc42 Cell division cycle 42 homolog (S. cerevisiae) 0.73 NM_001033443 Cdkl4 Cyclin-dependent kinase-like 4 0.66 NM_027839 Ceacam20 CEA-related cell adhesion molecule 20 0.66 NM_025475 Cep27 Centrosomal protein 27 0.71 NM_009892 Chi3l3 Chitinase 3-like 3 0.59 NM_145126 Chi3l4 Chitinase 3-like 4 0.60

31 NM_134007 Cisd1 CDGSH iron sulfur domain 1 0.72 NM_007710 Ckm , muscle 0.63 NM_011930 Clcn7 Chloride channel 7 0.67 NM_027562 Clec2g C-type lectin domain family 2, member g 0.71 NM_009904 Clgn Calmegin 0.71 NM_019649 Clptm1 Cleft lip and palate associated transmembrane protein 1 0.72 NM_053096 Cml2 Camello-like 2 0.41 NM_026949 Cnot8 CCR4-NOT transcription complex, subunit 8 0.62 NM_007727 Cntn1 Contactin 1 0.71 NM_017383 Cntn6 Contactin 6 0.66 NM_130449 Colec12 Collectin sub-family member 12 0.73 NM_001039710 Coq10b Coenzyme Q10 homolog B (S. cerevisiae) 0.73 NM_026452 Coq9 Coenzyme Q9 homolog (yeast) 0.62 NM_030205 Coro7 Coronin 7 0.55 NM_007757 Cpox Coproporphyrinogen oxidase 0.71 NM_178576 Cpsf4 Cleavage and specific factor 4 0.71 NM_153107 Cpz Carboxypeptidase Z 0.72 NM_031402 Crispld1 Cysteine-rich secretory protein LCCL domain containing 1 0.72 NM_007796 Ctla2a Cytotoxic T lymphocyte-associated protein 2 alpha 0.49 NM_007809 Cyp17a1 Cytochrome P450, family 17, subfamily a, polypeptide 1 0.62 NM_010002 Cyp2c38 Cytochrome P450, family 2, subfamily c, polypeptide 38 0.72 NM_206537 Cyp2c50 Cytochrome P450, family 2, subfamily c, polypeptide 50 0.72 NM_206537 Cyp2c50 Cytochrome P450, family 2, subfamily c, polypeptide 50 0.72 NM_001011707 Cyp2c66 Cytochrome P450, family 2, subfamily c, polypeptide 66 0.60 NM_001024719 Cyp2c67 Cytochrome P450, family 2, subfamily c, polypeptide 67 0.64 NM_145499 Cyp2c70 Cytochrome P450, family 2, subfamily c, polypeptide 70 0.70 NM_013809 Cyp2g1 Cytochrome P450, family 2, subfamily g, polypeptide 1 0.48 NM_134127 Cyp4f15 Cytochrome P450, family 4, subfamily f, polypeptide 15 0.70 NM_173436 Cypt2 Cysteine-rich perinuclear theca 2 0.70 NM_173367 Cypt3 Cysteine-rich perinuclear theca 3 0.65 NM_001013379 D10627 CDNA sequence D10627 0.70 NM_145959 D15Ertd621e DNA segment, Chr 15, ERATO Doi 621, expressed 0.70 NM_134100 D15Mgi27 DNA Segment, Chr 15, Mouse Genome Informatics 27 0.73 NM_198675 D630004A14Rik RIKEN cDNA D630004A14 gene 0.70 NM_027030 Dcps Decapping enzyme, scavenger 0.71 NM_001004364 Ddef2 Development and differentiation enhancing factor 2 0.66 NM_134040 Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.72 NM_013756 Defb3 Defensin beta 3 0.67 NM_181683 Defb37 Defensin beta 37 0.72 NM_183038 Defb39 Defensin beta 39 0.57 NM_054074 Defb6 Defensin beta 6 0.67 NM_153108 Defb8 Defensin beta 8 0.70 NM_183253 Defcr22 Defensin related cryptdin 22 0.72 NM_001024225 Defcr24 Defensin related cryptdin 24 0.67 NM_007850 Defcr3 Defensin related cryptdin 3 0.72 NM_007850 Defcr3 Defensin related cryptdin 3 0.72 NM_010043 Des 0.72 NM_028136 Dhx36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.72 NM_019670 Diap3 Diaphanous homolog 3 (Drosophila) 0.70 NM_175647 Dmrta1 Doublesex and mab-3 related transcription factor like family A1 0.72 NM_153743 Dnmt3a DNA methyltransferase 3A 0.65 NM_001009947 Dedicator of cytokinesis 11 0.68 NM_026767 Dpm3 Dolichyl-phosphate polypeptide 3 0.73 NM_170778 Dpyd Dihydropyrimidine dehydrogenase 0.73 NM_007887 Dub1 1 0.71 NM_028099 Dusp11 Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.64 NM_023173 Dusp12 Dual specificity phosphatase 12 0.66 NM_029851 Dync2h1 Dynein cytoplasmic 2 heavy chain 1 0.72 NM_172831 E230025N22Rik Riken cDNA E230025N22 gene 0.73 NM_175528 E330009J07Rik RIKEN cDNA E330009J07 gene 0.68 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 0.53 NM_001012324 Ecm2 Extracellular matrix protein 2, female organ and adipocyte specific 0.72 NM_153799 Edc3 Enhancer of mRNA decapping 3 homolog (S. cerevisiae) 0.65 NM_001038676 EG194588 Predicted gene, EG194588 0.67

32 NM_001001318 EG209380 Predicted gene, EG209380 0.65 NM_177596 EG210853 Predicted gene, EG210853 0.63 NM_001038995 EG214321 Predicted gene, EG214321 0.68 NM_177890 EG233164 Predicted gene, EG233164 0.67 NM_001034864 EG236749 Predicted gene, EG236749 0.70 NM_001033767 EG240327 Predicted gene, EG240327 0.71 NM_001034869 EG245263 Predicted gene, EG245263 0.50 NM_183309 EG330305 Predicted gene, EG330305 0.56 NM_001034882 EG432879 Predicted gene, EG432879 0.53 NM_001013816 EG434459 Predicted gene, EG434459 0.55 NM_001013820 EG434674 Predicted gene, EG434674 0.69 NM_001013825 EG435366 Predicted gene, EG435366 0.71 NM_001034102 EG545047 Predicted gene, EG545047 0.59 NM_001034103 EG546347 Predicted gene, EG546347 0.69 NM_001034909 EG547347 Predicted gene, EG547347 0.73 NM_001034909 EG547347 Predicted gene, EG547347 0.73 NM_001037922 EG624855 Predicted gene, EG624855 0.71 NM_001039250 EG638695 Predicted gene, EG638695 0.64 NM_026114 Eif2s1 Eukaryotic translation initiation factor 2, subunit 1 alpha 0.72 NM_016876 Eif3g Eukaryotic translation initiation factor 3, subunit G 0.71 NM_172703 Eif4g3 Eukaryotic translation initiation factor 4 gamma, 3 0.73 NM_010130 Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.70 NM_001025388 Eno1 Enolase 1, alpha non-neuron 0.72 NM_198666 ENSMUSG00000033219 Predicted gene, ENSMUSG00000033219 0.72 NM_026170 Ergic1 -golgi intermediate compartment (ERGIC) 1 0.72 NM_028039 Esco2 Establishment of cohesion 1 homolog 2 (S. cerevisiae) 0.70 NM_025513 Exosc3 Exosome component 3 0.67 NM_010164 Eya1 Eyes absent 1 homolog (Drosophila) 0.73 NM_007970 Ezh1 Enhancer of zeste homolog 1 (Drosophila) 0.62 NM_028066 F11 Coagulation factor XI 0.57 NM_007986 Fap Fibroblast activation protein 0.63 NM_015795 Fbxo16 F-box protein 16 0.70 NM_001037997 Fert2 Fer (fms/fps related) protein kinase, testis specific 2 0.63 NM_022657 Fgf23 Fibroblast growth factor 23 0.68 NM_008007 Fgf3 Fibroblast growth factor 3 0.68 NM_008009 Fgfbp1 Fibroblast growth factor binding protein 1 0.72 NM_008019 Fkbp1a FK506 binding protein 1a 0.52 NM_178382 Flrt3 leucine rich transmembrane protein 3 0.72 NM_008029 Flt4 FMS-like tyrosine kinase 4 0.71 NM_177091 Fndc7 Fibronectin type III domain containing 7 0.63 NM_172673 Frmd5 FERM domain containing 5 0.69 NM_013523 Fshr Follicle stimulating hormone receptor 0.70 NM_008655 Gadd45b Growth arrest and DNA-damage-inducible 45 beta 0.65 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_173030 Galnt13 acetylgalactosaminyltransferase 13 0.65 NM_026033 Gatad1 GATA zinc finger domain containing 1 0.71 NM_178930 Gbf1 Golgi-specific brefeldin A-resistance factor 1 0.72 NM_139197 Gbgt1 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 0.72 NM_010260 Gbp2 Guanylate nucleotide binding protein 2 0.72 NM_028900 Gcc1 Golgi coiled coil 1 0.73 NM_133219 Gcnt2 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme 0.71 NM_010266 Gda 0.62 NM_026223 Glipr1l2 GLI pathogenesis-related 1 like 2 0.69 NM_001005425 Gm1008 Gene model 1008, (NCBI) 0.68 NM_201366 Gm1631 Gene model 1631, (NCBI) 0.69 NM_198961 Gm1961 Gene model 1961, (NCBI) 0.62 NM_001013751 Gm52 Gene model 52, (NCBI) 0.72 NM_203508 Gm75 Gene model 75, (NCBI) 0.70 NM_001033417 Gm766 Gene model 766, (NCBI) 0.66 NM_001034872 Gm853 Gene model 853, (NCBI) 0.69 NM_146041 Gmds GDP-mannose 4, 6-dehydratase 0.73 NM_198169 Gmeb2 Glucocorticoid modulatory element binding protein 2 0.71 NM_015828 Gne Glucosamine 0.70 NM_019425 Gnpnat1 Glucosamine-phosphate N-acetyltransferase 1 0.72

33 NM_029727 Gsdm2 Gasdermin 2 0.59 NM_010360 Gstm5 Glutathione S-transferase, mu 5 0.72 NM_133994 Gstt3 Glutathione S-transferase, theta 3 0.72 NM_029472 Gstt4 Glutathione S-transferase, theta 4 0.69 NM_145546 Gtf2b General transcription factor IIB 0.72 NM_027901 Gtf3c2 General transcription factor IIIC, polypeptide 2, beta 0.71 NM_028450 Gulp1 GULP, engulfment adaptor PTB domain containing 1 0.65 NM_001039202 Hdhd2 Haloacid dehalogenase-like hydrolase domain containing 2 0.58 NM_172757 Heatr3 HEAT repeat containing 3 0.72 NM_010417 Heph 0.61 NM_010422 Hexb Hexosaminidase B 0.62 NM_016868 Hif3a Hypoxia inducible factor 3, alpha subunit 0.71 NM_025933 Higd2a HIG1 domain family, member 2A 0.69 NM_008248 Hint1 Histidine triad nucleotide binding protein 1 0.62 NM_175658 Hist1h2aa Histone cluster 1, H2aa 0.65 NM_178196 Hist1h2bg Histone cluster 1, H2bg 0.65 NM_178193 Hist1h4b Histone cluster 1, H4b 0.72 NM_178017 Hmgb2l1 High mobility group box 2-like 1 0.73 NM_080462 Hnmt N-methyltransferase 0.65 NM_198090 Hnrpa3 Heterogeneous nuclear ribonucleoprotein A3 0.71 NM_176785 Hps6 Hermansky-Pudlak syndrome 6 0.72 NM_008284 Hras1 Harvey rat sarcoma virus oncogene 1 0.68 NM_198030 Hsd17b13 Hydroxysteroid (17-beta) dehydrogenase 13 0.59 NM_008295 Hsd3b5 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.72 NM_030704 Hspb8 Heat shock protein 8 0.72 NM_025378 Ifitm3 Interferon induced transmembrane protein 3 0.72 NM_011879 Ik IK cytokine 0.69 NM_153077 Il1f10 Interleukin 1 family, member 10 0.63 NM_021782 Il21 0.70 NM_010558 Il5 Interleukin 5 0.59 NM_008372 Il7r receptor 0.67 NM_176843 Ints5 Integrator complex subunit 5 0.71 NM_207217 Itfg3 Integrin alpha FG-GAP repeat containing 3 0.73 NM_008401 Itgam 0.64 NM_010587 Itsn1 Intersectin 1 (SH3 domain protein 1A) 0.72 NM_153572 Katnal1 Katanin p60 subunit A-like 1 0.73 NM_019715 Kcmf1 Potassium channel modulatory factor 1 0.65 NM_013568 Kcna6 Potassium voltage-gated channel, -related, subfamily, member 6 0.69 NM_001039482 Klhl20 Kelch-like 20 (Drosophila) 0.71 NM_182782 Klhl25 Kelch-like 25 (Drosophila) 0.72 NM_010643 Klk1b24 Kallikrein 1-related peptidase b24 0.66 NM_008456 Klk1b5 Kallikrein 1-related peptidase b5 0.73 NM_008464 Klra19 Killer cell lectin-like receptor, subfamily A, member 19 0.65 NM_008463 Klra5 Killer cell lectin-like receptor, subfamily A, member 5 0.63 NM_010651 Klra9 Killer cell lectin-like receptor subfamily A, member 9 0.69 NM_010737 Klrb1a Killer cell lectin-like receptor subfamily B member 1A 0.71 NM_008465 Kpna1 Karyopherin (importin) alpha 1 0.68 NM_212487 Krt78 Keratin 78 0.71 NM_001037822 Krtap5-5 Keratin associated protein 5-5 0.71 NM_133892 Lao1 L- oxidase 1 0.70 NM_008640 Laptm4a Lysosomal-associated protein transmembrane 4A 0.70 NM_008879 Lcp1 Lymphocyte cytosolic protein 1 0.69 NM_010709 Lgtn Ligatin 0.72 NM_008498 Lhx1 LIM homeobox protein 1 0.72 NM_008501 Lif Leukemia inhibitory factor 0.72 NM_026334 Lipf Lipase, gastric 0.67 NM_001037918 Lipt1 Lipoyltransferase 1 0.70 NM_145438 Llgl2 Lethal giant larvae homolog 2 (Drosophila) 0.72 NM_177178 Lmbrd2 LMBR1 domain containing 2 0.66 NM_019390 Lmna Lamin A 0.71 NM_177187 LOC100041354 Similar to D5Ertd577e protein 0.67 NM_207162 LOC382133 Similar to RIKEN cDNA 1700029H17 0.70 NM_001025241 LOC434960 Similar to spermiogenesis specific transcript on the Y 2 0.72 NM_001029878 Lonrf2 LON peptidase N-terminal domain and ring finger 2 0.70

34 NM_026648 Lrrc50 Leucine rich repeat containing 50 0.69 NM_028915 Lrrcc1 Leucine rich repeat and coiled-coil domain containing 1 0.59 NM_146191 Lrrk1 Leucine-rich repeat kinase 1 0.72 NM_178731 Lrrtm4 Leucine rich repeat transmembrane neuronal 4 0.69 NM_008866 Lypla1 Lysophospholipase 1 0.54 NM_010749 M6pr Mannose-6-phosphate receptor, cation dependent 0.70 NM_025649 Mad2l1bp MAD2L1 binding protein 0.69 NM_020020 Magea8 Melanoma antigen, family A, 8 0.69 NM_008696 Map4k4 Mitogen-activated protein kinase kinase kinase kinase 4 0.69 NM_001003913 Mars Methionine-tRNA synthetase 0.71 NM_013593 Mb 0.60 NM_134012 Mbtd1 Mbt domain containing 1 0.57 NM_010786 Transformed mouse 3T3 cell double minute 2 0.68 NM_010790 Melk Maternal embryonic kinase 0.69 NM_008588 Mesp1 Mesoderm posterior 1 0.73 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, NM_026243 Mgat4c C (putative) 0.68 NM_001017393 MGC107098 Similar to spermiogenesis specific transcript on the Y 2 0.71 NM_001017393 MGC107098 Similar to spermiogenesis specific transcript on the Y 2 0.71 Myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog NM_022328 Mllt1 (Drosophila) 0.71 Myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog NM_027326 Mllt3 (Drosophila) 0.72 Myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog NM_029931 Mllt3 (Drosophila) 0.71 NM_026143 Mlstd2 Male sterility domain containing 2 0.72 NM_019471 Mmp10 Matrix metallopeptidase 10 0.73 NM_194269 Morn2 MORN repeat containing 2 0.65 NM_026242 Mrfap1 Morf4 family associated protein 1 0.65 NM_205821 Mrgpra6 MAS-related GPR, member A6 0.66 NM_205810 Mrgprb1 MAS-related GPR, member B1 0.69 NM_017404 Mrpl39 Mitochondrial ribosomal protein L39 0.73 NM_025595 Mrpl51 Mitochondrial ribosomal protein L51 0.67 NM_010827 Msc Musculin 0.72 NM_178051 Mterfd2 MTERF domain containing 2 0.68 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent), NM_138745 Mthfd1 methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase 0.64 NM_008098 Mtpn Myotrophin 0.67 NM_175374 Mtrf1l Mitochondrial translational release factor 1-like 0.69 NM_008645 Mug1 Murinoglobulin 1 0.72 NM_001039544 Mup3 Major urinary protein 3 0.50 NM_008648 Mup4 Major urinary protein 4 0.60 NM_008649 Mup5 Major urinary protein 5 0.60 NM_008650 Mut Methylmalonyl-Coenzyme A mutase 0.72 NM_133762 Ncapg2 Non-SMC condensin II complex, subunit G2 0.64 NM_133666 Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.59 NM_021360 Neurl Neuralized-like homolog (Drosophila) 0.70 NM_178877 Nhedc2 Na+/H+ exchanger domain containing 2 0.65 NM_022988 Nif3l1 Ngg1 interacting factor 3-like 1 (S. pombe) 0.65 NM_025719 Nkapl RIKEN cDNA 4921504I05 gene 0.72 NM_172896 Nlrp4a NLR family, containing 4A 0.69 NM_178071 Nme7 Non-metastatic cells 7, protein expressed in 0.68 NM_020043 Nope Neighbor of Punc E11 0.71 NM_028749 Npl N-acetylneuraminate pyruvate 0.67 NM_026012 Nradd Neurotrophin receptor associated 0.72 NM_021717 Nrip2 Nuclear receptor interacting protein 2 0.70 NM_198326 Nsfl1c NSFL1 (p97) (p47) 0.60 NM_028950 Nsun6 NOL1/NOP2/Sun domain family 6 0.71 NM_027588 Nt5c1b 5'-, cytosolic IB 0.68 NM_013745 Nufip1 Nuclear fragile X mental retardation protein interacting protein 1 0.73 NM_022979 Nup98 Nucleoporin 98 0.72 NM_145211 Oas1a 2'-5' oligoadenylate synthetase 1A 0.71 NM_027802 Obox1 Oocyte specific homeobox 1 0.59 NM_145707 Obox3 Oocyte specific homeobox 3 0.70

35 NM_146573 Olfr1002 Olfactory receptor 1002 0.71 NM_146588 Olfr1030 Olfactory receptor 1030 0.69 NM_147017 Olfr1045 Olfactory receptor 1045 0.71 NM_147016 Olfr1049 Olfactory receptor 1049 0.73 NM_147010 Olfr1052 Olfactory receptor 1052 0.70 NM_001011735 Olfr1066 Olfactory receptor 1066 0.51 NM_146406 Olfr1076 Olfactory receptor 1076 0.69 NM_146592 Olfr1086 Olfactory receptor 1086 0.70 NM_001011771 Olfr1089 Olfactory receptor 1089 0.45 NM_146767 Olfr1104 Olfactory receptor 1104 0.73 NM_146351 Olfr1133 Olfactory receptor 1133 0.71 NM_146642 Olfr1140 Olfactory receptor 1140 0.72 NM_146849 Olfr1157 Olfactory receptor 1157 0.60 NM_207566 Olfr1173 Olfactory receptor 1173 0.57 NM_001011804 Olfr1211 Olfactory receptor 1211 0.66 NM_146288 Olfr122 Olfactory receptor 122 0.73 NM_146791 Olfr1248 Olfactory receptor 1248 0.63 NM_146887 Olfr1301 Olfactory receptor 1301 0.71 NM_146402 Olfr1303 Olfactory receptor 1303 0.72 NM_146332 Olfr135 Olfactory receptor 135 0.69 NM_146534 Olfr1368 Olfactory receptor 1368 0.70 NM_207253 Olfr1371 Olfactory receptor 1371 0.71 NM_147039 Olfr1414 Olfactory receptor 1414 0.70 NM_001011525 Olfr1415 Olfactory receptor 1415 0.70 NM_147038 Olfr1416 Olfactory receptor 1416 0.71 NM_001011839 Olfr1437 Olfactory receptor 1437 0.70 NM_146703 Olfr1447 Olfactory receptor 1447 0.73 NM_146692 Olfr1454 Olfactory receptor 1454 0.66 NM_146575 Olfr1457 Olfactory receptor 1457 0.70 NM_146797 Olfr1502 Olfactory receptor 1502 0.69 NM_146451 Olfr164 Olfactory receptor 164 0.71 NM_146485 Olfr183 Olfactory receptor 183 0.73 NM_146321 Olfr186 Olfactory receptor 186 0.71 NM_146397 Olfr190 Olfactory receptor 190 0.68 NM_001011791 Olfr193 Olfactory receptor 193 0.72 NM_001011800 Olfr212 Olfactory receptor 212 0.57 NM_001011752 Olfr293 Olfactory receptor 293 0.70 NM_147027 Olfr31 Olfactory receptor 31 0.67 NM_146536 Olfr313 Olfactory receptor 313 0.69 NM_147073 Olfr33 Olfactory receptor 33 0.71 NM_146947 Olfr338 Olfactory receptor 338 0.72 NM_146938 Olfr346 Olfactory receptor 346 0.72 NM_146656 Olfr444 Olfactory receptor 444 0.65 NM_001011810 Olfr485 Olfactory receptor 485 0.67 NM_146498 Olfr490 Olfactory receptor 490 0.71 NM_146914 Olfr5 Olfactory receptor 5 0.69 NM_001011858 Olfr504 Olfactory receptor 504 0.73 NM_001011793 Olfr598 Olfactory receptor 598 0.67 NM_001011865 Olfr624 Olfactory receptor 624 0.67 NM_147097 Olfr628 Olfactory receptor 628 0.68 NM_020290 Olfr690 Olfactory receptor 690 0.71 NM_028910 Olfr701 Olfactory receptor 701 0.59 NM_146604 Olfr716 Olfactory receptor 716 0.59 NM_146339 Olfr77 Olfactory receptor 77 0.73 NM_146544 Olfr777 Olfactory receptor 777 0.70 NM_146728 Olfr781 Olfactory receptor 781 0.61 NM_001011797 Olfr782 Olfactory receptor 782 0.64 NM_146729 Olfr784 Olfactory receptor 784 0.72 NM_146549 Olfr786 Olfactory receptor 786 0.72 NM_001011849 Olfr792 Olfactory receptor 792 0.69 NM_146929 Olfr807 Olfactory receptor 807 0.70 NM_146673 Olfr823 Olfactory receptor 823 0.70 NM_146524 Olfr855 Olfactory receptor 855 0.72 NM_146785 Olfr915 Olfactory receptor 915 0.64

36 NM_001011812 Olfr951 Olfactory receptor 951 0.67 NM_146612 Olfr968 Olfactory receptor 968 0.69 NM_147107 Olfr974 Olfactory receptor 974 0.73 NM_146828 Olfr975 Olfactory receptor 975 0.62 NM_146615 Olfr986 Olfactory receptor 986 0.62 NM_013887 Opn4 4 () 0.71 NM_008765 Orc2l Origin recognition complex, subunit 2-like (S. cerevisiae) 0.64 NM_145517 Ormdl1 ORM1-like 1 (S. cerevisiae) 0.62 NM_011022 Ott Ovary testis transcribed 0.64 NM_011022 Ott Ovary testis transcribed 0.64 NM_011022 Ott Ovary testis transcribed 0.64 NM_011022 Ott Ovary testis transcribed 0.64 NM_011022 Ott Ovary testis transcribed 0.64 NM_011022 Ott Ovary testis transcribed 0.64 NM_001009550 OTTMUSG00000000231 Predicted gene, OTTMUSG00000000231 0.72 NM_001012323 OTTMUSG00000007485 Predicted gene, OTTMUSG00000007485 0.53 NM_001037926 OTTMUSG00000010173 Predicted gene, OTTMUSG00000010173 0.70 NM_001005371 OTTMUSG00000010328 Predicted gene, OTTMUSG00000010328 0.69 NM_177571 OTTMUSG00000010433 Predicted gene, OTTMUSG00000010433 0.67 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.64 NM_001039209 OTTMUSG00000010671 Predicted gene, OTTMUSG00000010671 0.72 NM_001014397 OTTMUSG00000010673 Predicted gene, OTTMUSG00000010673 0.69 NM_001013808 OTTMUSG00000010965 Predicted gene, OTTMUSG00000010965 0.71 Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), NM_011030 P4ha1 alpha 1 polypeptide 0.62 NM_001013580 Pard3 Par-3 (partitioning defective 3) homolog (C. elegans) 0.68 NM_030253 Parp9 Poly (ADP-ribose) polymerase family, member 9 0.73 NM_026701 Pbld Phenazine biosynthesis-like containing 0.71 NM_053126 Pcdhb1 beta 1 0.68 NM_053140 Pcdhb15 Protocadherin beta 15 0.71 NM_153565 Pcsk9 Proprotein convertase subtilisin/kexin type 9 0.69 NM_172832 Pcyox1l Prenylcysteine oxidase 1 like 0.72 NM_133667 Pdk2 Pyruvate dehydrogenase kinase, isoenzyme 2 0.71 NM_023041 Pex19 Peroxisome biogenesis factor 19 0.71 NM_028730 Pex26 Peroxisome biogenesis factor 26 0.58 NM_011070 Pfdn2 Prefoldin 2 0.70 NM_001013369 Pfdn4 Prefoldin 4 0.73 NM_021453 Pga5 Pepsinogen 5, group I 0.64 NM_025396 Pgls 6-phosphogluconolactonase 0.64 NM_001005740 Phactr1 Phosphatase and actin regulator 1 0.73 NM_172603 Phf11 PHD finger protein 11 0.71 NM_029404 Phf14 PHD finger protein 14 0.65 NM_028521 Phospho2 Phosphatase, orphan 2 0.72 NM_172992 Phtf2 Putative homeodomain transcription factor 2 0.72 NM_029406 Pih1d1 PIH1 domain containing 1 0.68 NM_181414 Pik3c3 Phosphoinositide-3-kinase, class 3 0.69 NM_008848 Pira6 Paired-Ig-like receptor A6 0.59 NM_008848 Pira6 Paired-Ig-like receptor A6 0.59 NM_021308 Piwil2 Piwi-like homolog 2 (Drosophila) 0.71 NM_177905 Piwil4 Piwi-like homolog 4 (Drosophila) 0.73 NM_008862 Pkia Protein kinase inhibitor, alpha 0.62 NM_134102 Pla1a member A 0.58 NM_013737 Pla2g7 Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.73 NM_178911 Pld4 Phospholipase D family, member 4 0.53 Pleckstrin homology domain containing, family G (with RhoGef domain) NM_001033253 Plekhg1 member 1 0.73 NM_025928 Pmf1 Polyamine-modulated factor 1 0.69 NM_026329 Polr2g Polymerase (RNA) II (DNA directed) polypeptide G 0.71 NM_026340 Pop1 Processing of precursor 1, /MRP family, (S. cerevisiae) 0.71 NM_023785 Ppbp Pro-platelet basic protein 0.72 NM_001033453 Ppm2c Protein phosphatase 2C, magnesium dependent, catalytic subunit 0.69 NM_016979 Prkx Protein kinase, X-linked 0.70 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 0.73 NM_011120 Prl7d1 Prolactin family 7, subfamily d, member 1 0.67

37 NM_027541 Prpf3 PRP3 pre-mRNA processing factor 3 homolog (yeast) 0.71 NM_172487 Prrt3 Proline-rich transmembrane protein 3 0.70 NM_009116 Prrx2 Paired related homeobox 2 0.68 NM_011182 Pscd3 Pleckstrin homology, Sec7 and coiled-coil domains 3 0.70 NM_054060 Psg25 Pregnancy-specific glycoprotein 25 0.73 NM_008948 Psmc3 Proteasome (prosome, macropain) 26S subunit, ATPase 3 0.68 NM_134013 Psme4 Proteasome (prosome, macropain) activator subunit 4 0.70 NM_025682 Pspc1 Paraspeckle protein 1 0.73 NM_011198 Ptgs2 Prostaglandin-endoperoxide synthase 2 0.73 NM_011204 Ptpn13 Protein tyrosine phosphatase, non-receptor type 13 0.71 NM_029928 Ptprb Protein tyrosine phosphatase, receptor type, B 0.67 NM_009005 Rab7 RAB7, member RAS oncogene family 0.66 NM_013862 Rabgap1l GTPase activating protein 1-like 0.71 NM_012025 Racgap1 Rac GTPase-activating protein 1 0.71 NM_009826 Rb1cc1 RB1-inducible coiled-coil 1 0.71 NM_198302 Rbm11 RNA binding motif protein 11 0.71 NM_029397 Rbm12 RNA binding motif protein 12 0.66 NM_172762 Rbm34 RNA binding motif protein 34 0.60 NM_025875 Rbm8a RNA binding motif protein 8a 0.71 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.69 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.69 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.69 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.69 NM_009048 Reps1 RalBP1 associated Eps domain containing protein 0.72 NM_181988 Rerg RAS-like, -regulated, growth-inhibitor 0.60 NM_020509 Retnla Resistin like alpha 0.55 NM_181596 Retnlg Resistin like gamma 0.69 NM_178916 Rfesd Rieske (Fe-S) domain containing 0.61 NM_015811 Rgs1 Regulator of G-protein signaling 1 0.73 NM_011268 Rgs9 Regulator of G-protein signaling 9 0.67 NM_025934 Riok2 RIO kinase 2 (yeast) 0.52 NM_009543 Rnf103 Ring finger protein 103 0.66 NM_153503 Rnf113a1 Ring finger protein 113A1 0.67 NM_019996 Rnuxa RNA U, small nuclear RNA export adaptor 0.68 NM_183280 RP23-438H3.2 Hypothetical protein LOC69357 0.67 NM_183280 RP23-438H3.2 Hypothetical protein LOC69357 0.67 NM_025586 Rpl15 Ribosomal protein L15 0.52 NM_133982 Rpp25 Ribonuclease P 25 subunit (human) 0.71 NM_013725 Rps11 Ribosomal protein S11 0.66 NM_016959 Rps3a Ribosomal protein S3a 0.71 NM_009094 Rps4x Ribosomal protein S4, X-linked 0.57 NM_017475 Rragc Ras-related GTP binding C 0.57 NM_001013769 Rsl1 Regulator of sex limited protein 1 0.73 NM_001007596 Rtn1 Reticulon 1 0.73 NM_016682 Sae2 SUMO1 activating enzyme subunit 2 0.64 NM_016807 Sdcbp Syndecan binding protein 0.68 NM_009150 Selenbp1 Selenium binding protein 1 0.71 NM_146003 Senp6 SUMO/sentrin specific peptidase 6 0.51 NM_172490 Sepsecs Sep (O-phosphoserine) tRNA:Sec () tRNA synthase 0.70 NM_011353 Serf1 Small EDRK-rich factor 1 0.68 NM_173024 Serpina3b Serine (or cysteine) peptidase inhibitor, clade A, member 3B 0.72 NM_008458 Serpina3c Serine (or cysteine) peptidase inhibitor, clade A, member 3C 0.65 NM_009126 Serpinb3a Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A 0.59 NM_009254 Serpinb6a Serine (or cysteine) peptidase inhibitor, clade B, member 6a 0.57 NM_148942 Serpinb6c Serine (or cysteine) peptidase inhibitor, clade B, member 6c 0.60 NM_011456 Serpinb9e Serine (or cysteine) peptidase inhibitor, clade B, member 9e 0.66 NM_001013370 Sesn1 Sestrin 1 0.72 NM_145482 Setd4 SET domain containing 4 0.60 NM_018877 Setdb1 SET domain, bifurcated 1 0.70 NM_198033 Setx Senataxin 0.69 NM_026175 Sf3a1 Splicing factor 3a, subunit 1 0.73 NM_031179 Sf3b1 Splicing factor 3b, subunit 1 0.73 NM_012009 Sh2d1b1 SH2 domain protein 1B1 0.56 NM_009174 Siah2 Seven in absentia 2 0.71

38 NM_030696 Slc16a3 Solute carrier family 16 (monocarboxylic acid transporters), member 3 0.67 NM_021712 Slc18a3 Solute carrier family 18 (vesicular monoamine), member 3 0.64 NM_009202 Slc22a1 Solute carrier family 22 (organic cation transporter), member 1 0.72 NM_008766 Slc22a6 Solute carrier family 22 (organic anion transporter), member 6 0.57 NM_144793 Slc25a38 Solute carrier family 25, member 38 0.71 NM_001039677 Slc30a2 Solute carrier family 30 (zinc transporter), member 2 0.57 NM_178651 Slc30a9 Solute carrier family 30 (zinc transporter), member 9 0.71 NM_172258 Slc36a3 Solute carrier family 36 (proton/amino acid symporter), member 3 0.67 NM_026721 Slc39a13 Solute carrier family 39 (metal transporter), member 13 0.72 NM_177802 Slc7a15 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 0.59 NM_023718 Slco1a6 Solute carrier organic anion transporter family, member 1a6 0.60 NM_011409 Slfn3 Schlafen 3 0.73 NM_148673 Slu7 SLU7 splicing factor homolog (S. cerevisiae) 0.73 NM_172429 Smndc1 Survival motor neuron domain containing 1 0.66 NM_020561 Smpdl3a Sphingomyelin phosphodiesterase, acid-like 3A 0.73 NM_023348 Snap29 Synaptosomal-associated protein 0.71 NM_009221 Snca Synuclein, alpha 0.70 NM_021336 Snrpa1 Small nuclear ribonucleoprotein polypeptide A' 0.73 NM_009225 Snrpb Small nuclear ribonucleoprotein B 0.72 NM_172926 Snx14 14 0.68 NM_207213 Snx25 Sorting nexin 25 0.65 NM_029599 Spag4l Sperm associated antigen 4-like 0.71 NM_025668 Spcs2 Signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.72 NM_028561 Speer4b Spermatogenesis associated glutamate (E)-rich protein 4b 0.64 NM_025759 Speer4d Spermatogenesis associated glutamate (E)-rich protein 4d 0.66 NM_144895 Spg20 Spastic paraplegia 20, spartin (Troyer syndrome) homolog (human) 0.59 NM_145584 Spon1 Spondin 1, (f-spondin) extracellular matrix protein 0.70 NM_011469 Sprr2b Small proline-rich protein 2B 0.72 NM_009273 Srp14 Signal recognition particle 14 0.66 NM_146032 Srp68 Signal recognition particle 68 0.71 NM_029688 Srxn1 Sulfiredoxin 1 homolog (S. cerevisiae) 0.66 NM_199064 Ssxb10 Synovial sarcoma, X member B, breakpoint 10 0.66 NM_199319 Ssxb5 Synovial sarcoma, X member B, breakpoint 5 0.73 NM_178048 St3gal2 ST3 beta-galactoside alpha-2,3- 2 0.68 NM_146028 Stac2 SH3 and cysteine rich domain 2 0.71 NM_029682 Stambpl1 Stam binding protein like 1 0.67 NM_173869 Stfa2l1 Stefin A2 like 1 0.68 NM_009185 Stil Scl/Tal1 interrupting locus 0.69 NM_016866 Stk39 Serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.73 NM_175162 Stox2 Storkhead box 2 0.72 NM_018751 Sult1c1 Sulfotransferase family, cytosolic, 1C, member 1 0.60 NM_027832 Sval1 Seminal vesicle antigen-like 1 0.66 NM_028769 Syvn1 Synovial apoptosis inhibitor 1, synoviolin 0.69 NM_001010827 Taar7b Trace amine-associated receptor 7B 0.61 NM_027748 Taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.65 NM_207018 Tas2r113 Taste receptor, type 2, member 113 0.73 NM_001025385 Tas2r137 Taste receptor, type 2, member 137 0.67 NM_001001451 Tas2r138 Taste receptor, type 2, member 138 0.72 NM_013775 Tcl1b2 T-cell leukemia/lymphoma 1B, 2 0.68 NM_001007222 Tdpoz2 TD and POZ domain containing 2 0.71 NM_207273 Tdpoz5 TD and POZ domain containing 5 0.60 NM_207273 Tdpoz5 TD and POZ domain containing 5 0.60 NM_001039153 Tect1 Tectonic 1 0.72 NM_198292 Tex2 Testis expressed gene 2 0.66 NM_009357 Tex261 Testis expressed gene 261 0.71 NM_054089 Tgs1 Trimethylguanosine synthase homolog (S. cerevisiae) 0.72 NM_013691 Thbs3 Thrombospondin 3 0.63 NM_025416 Them5 Thioesterase superfamily member 5 0.71 NM_001001297 Thnsl1 Threonine synthase-like 1 (bacterial) 0.60 NM_178759 Timd4 T-cell immunoglobulin and mucin domain containing 4 0.70 NM_027016 Tloc1 Translocation protein 1 0.69 NM_026281 Tm7sf3 Transmembrane 7 superfamily member 3 0.63 NM_018872 Tmem131 Transmembrane protein 131 0.67 NM_027495 Tmem144 Transmembrane protein 144 0.62

39 NM_025335 Tmem167 Transmembrane protein 167 0.71 NM_133683 Tmem19 Transmembrane protein 19 0.71 NM_025439 Tmem9 Transmembrane protein 9 0.65 NM_001034896 Tmem92 Transmembrane protein 92 0.72 NM_025655 Tmigd1 Transmembrane and immunoglobulin domain containing 1 0.73 NM_183109 Tmprss12 Transmembrane protease, serine 12 0.70 NM_175091 Tnks Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.64 NM_025996 Tomm34 Translocase of outer mitochondrial membrane 34 0.71 NM_009409 Top2b Topoisomerase (DNA) II beta 0.71 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein 0.72 NM_144884 Tor1a Torsin family 1, member A (torsin A) 0.62 NM_172843 Tor1aip2 Torsin A interacting protein 2 0.72 NM_009417 Tpo Thyroid peroxidase 0.67 NM_016715 Tpte2 Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 0.64 NM_153792 Traf7 Tnf receptor-associated factor 7 0.67 NM_025701 Trappc5 Trafficking protein particle complex 5 0.69 NM_021447 Trim54 Tripartite motif-containing 54 0.70 NM_053167 Trim9 Tripartite motif protein 9 0.65 NM_011640 Trp53 Transformation related protein 53 0.69 NM_001038996 Try10 Trypsin 10 0.71 NM_028360 Ttc19 Tetratricopeptide repeat domain 19 0.70 NM_026213 Ttc33 Tetratricopeptide repeat domain 33 0.71 NM_030254 Tusc3 Tumor suppressor candidate 3 0.67 NM_019392 Tyro3 TYRO3 protein tyrosine kinase 3 0.71 NM_019912 Ube2d2 Ubiquitin-conjugating enzyme E2D 2 0.71 NM_033526 Ubqln4 Ubiquilin 4 0.73 NM_201641 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.72 NM_053215 Ugt2b37 UDP glucuronosyltransferase 2 family, polypeptide B37 0.69 NM_133894 Ugt2b38 UDP glucuronosyltransferase 2 family, polypeptide B38 0.65 NM_009467 Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.56 NM_025407 Uqcrc1 Ubiquinol-cytochrome c reductase core protein 1 0.66 NM_001038589 Usp14 Ubiquitin specific peptidase 14 0.68 NM_024258 Usp16 Ubiquitin specific peptidase 16 0.71 NM_019729 Usp8 Ubiquitin specific peptidase 8 0.61 NM_053224 V1ra9 Vomeronasal 1 receptor, A9 0.69 NM_053228 V1rb7 Vomeronasal 1 receptor, B7 0.66 NM_134166 V1rc11 Vomeronasal 1 receptor, C11 0.66 NM_134167 V1rc12 Vomeronasal 1 receptor, C12 0.64 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 0.66 NM_134169 V1rc14 Vomeronasal 1 receptor, C14 0.69 NM_053232 V1rc2 Vomeronasal 1 receptor, C2 0.54 NM_134180 V1rc25 Vomeronasal 1 receptor, C25 0.66 NM_134182 V1rc27 Vomeronasal 1 receptor, C27 0.68 NM_134184 V1rc29 Vomeronasal 1 receptor, C29 0.65 NM_206872 V1rd12 Vomeronasal 1 receptor, D12 0.69 NM_206872 V1rd12 Vomeronasal 1 receptor, D12 0.69 NM_206868 V1rd13 Vomeronasal 1 receptor, D13 0.66 NM_030736 V1rd14 Vomeronasal 1 receptor, D14 0.61 NM_206869 V1rd16 Vomeronasal 1 receptor, D16 0.55 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 0.59 NM_207618 V1rd18 Vomeronasal 1 receptor, D18 0.62 NM_207546 V1rd20 Vomeronasal 1 receptor, D20 0.53 NM_134202 V1rf5 Vomeronasal 1 receptor, F5 0.73 NM_134233 V1rg11 Vomeronasal 1 receptor, G11 0.60 NM_134206 V1rg5 Vomeronasal 1 receptor, G5 0.66 NM_134238 V1rh13 Vomeronasal 1 receptor, H13 0.71 NM_134243 V1rh20 Vomeronasal 1 receptor, H20 0.70 NM_134215 V1rh6 Vomeronasal 1 receptor, H6 0.58 NM_134220 V1ri3 Vomeronasal 1 receptor, I3 0.61 NM_134223 V1ri6 Vomeronasal 1 receptor, I6 0.72 NM_009487 V2r10 Vomeronasal 2, receptor, 10 0.67 NM_009490 V2r15 Vomeronasal 2, receptor, 15 0.69 NM_011692 Vbp1 Von Hippel-Lindau binding protein 1 0.69 NM_009503 Vcp Valosin containing protein 0.69

40 NM_175936 Vmn2r81 Vomeronasal 2, receptor 81 0.62 NM_011704 Vnn1 Vanin 1 0.59 NM_009514 Vpreb3 Pre-B lymphocyte gene 3 0.60 NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) 0.59 NM_178070 Vps33b Vacuolar protein sorting 33B (yeast) 0.71 NM_025362 Wbscr18 Williams-Beuren syndrome chromosome region 18 homolog (human) 0.73 NM_027057 Wdfy1 WD repeat and FYVE domain containing 1 0.69 NM_026137 Wdr13 WD repeat domain 13 0.67 NM_133734 Wdr23 WD repeat domain 23 0.68 NM_172445 Wdr37 WD repeat domain 37 0.73 NM_026044 Wdr85 WD40 repeat domain 85 0.68 NM_001012704 Wfdc13 WAP four-disulfide core domain 13 0.61 NM_011725 Xlr X-linked lymphocyte-regulated complex 0.51 NM_183094 Xlr4b X-linked lymphocyte-regulated 4B 0.62 NM_025347 Ypel3 Yippee-like 3 (Drosophila) 0.73 NM_009541 Zbtb17 Zinc finger and BTB domain containing 17 0.60 NM_175537 Zbtb38 Zinc finger and BTB domain containing 38 0.72 NM_199309 Zdhhc19 Zinc finger, DHHC domain containing 19 0.61 NM_021307 Zfp112 Zinc finger protein 112 0.69 NM_198322 Zfp273 Zinc finger protein 273 0.58 NM_026046 Zfp329 Zinc finger protein 329 0.72 NM_001009549 Zfp36l3 Zinc finger protein 36, C3H type-like 3 0.73 NM_027007 Zfp397 Zinc finger protein 397 0.72 NM_009555 Zfp40 Zinc finger protein 40 0.73 NM_173364 Zfp445 Zinc finger protein 445 0.67 NM_207255 Zfp532 Zinc finger protein 532 0.73 NM_011762 Zfp59 Zinc finger protein 59 0.65 NM_177622 Zfp595 Zin finger protein 595 0.54 NM_013844 Zfp68 Zinc finger protein 68 0.66 NM_001012448 Zfp708 Zinc finger protein 708 0.69 NM_145484 Zfp758 Zinc finger protein 758 0.59 NM_001037745 Zfp791 Zinc finger protein 791 0.72 NM_009567 Zfp93 Zinc finger protein 93 0.70 NM_133206 Znrf1 Zinc and ring finger 1 0.70 NM_016684 Zscan12 Zinc finger and SCAN domain containing 12 0.69 NM_001001737 0.69 NM_001002780 0.57 NM_001002781 0.50 NM_001004189 0.69 NM_001012311 0.73 NM_001013815 0.67 NM_001018010 0.67 NM_001024849 0.73 NM_001025564 0.69 NM_001033406 0.64 NM_001033788 0.58 NM_001037912 0.71 NM_001037920 0.73 NM_001039232 0.68 NM_020295 0.65 NM_026204 0.73 NM_026916 0.65 NM_027302 0.59 NM_027820 0.71 NM_028535 0.65 NM_029117 0.64 NM_029813 0.71 NM_134211 0.66 NM_153168 0.64 NM_172792 0.67 NM_175010 0.70 NM_177302 0.67 NM_177329 0.61 NM_177831 0.67

41 NM_177842 0.73 NM_198676 0.71

SUPPLEMENTAL TABLE S3: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in the Social Isolation Model (p<0.001)

Accession Number Symbol Name Fold Change NM_017380 9-Sep Septin 9 1.44 NM_053102 15-Sep Selenoprotein 1.47 NM_026714 0610037D15Rik RIKEN cDNA 0610037D15 gene 1.34 NM_025345 0610037P05Rik RIKEN cDNA 0610037P05 gene 1.35 NM_026753 1110019N10Rik RIKEN cDNA 1110019N10 gene 1.35 NM_025402 1110031I02Rik RIKEN cDNA 1110031I02 gene 1.38 NM_028773 1200013B08Rik RIKEN cDNA 1200013B08 gene 1.33 NM_033146 1500005A01Rik RIKEN cDNA 1500005A01 gene 1.75 NM_177132 1520401A03Rik RIKEN cDNA 1520401A03 gene 1.33 NM_026451 1600012H06Rik RIKEN cDNA 1600012H06 gene 1.56 NM_029639 1600029D21Rik RIKEN cDNA 1600029D21 gene 1.37 NM_028157 1700013B16Rik RIKEN cDNA 1700013B16 gene 1.52 NM_198637 1700016K19Rik RIKEN cDNA 1700016K19 gene 1.66 NM_027069 1700018F24Rik RIKEN cDNA 1700018F24 gene 1.55 NM_026469 1700025D03Rik RIKEN cDNA 1700025D03 gene 1.39 NM_026188 1700028P14Rik RIKEN cDNA 1700028P14 gene 1.43 NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene 1.41 NM_026096 1700054O13Rik RIKEN cDNA 1700054O13 gene 1.48 NM_001033184 1700057G04Rik RIKEN cDNA 1700057G04 gene 1.36 NM_028543 1700065O13Rik RIKEN cDNA 1700065O13 gene 1.33 NM_001033168 1700066B19Rik RIKEN cDNA 1700066B19 gene 1.38 NM_029714 1700067C01Rik RIKEN cDNA 1700067C01 gene 1.32 NM_001033765 1700071K01Rik RIKEN cDNA 1700071K01 gene 1.39 NM_025463 1810009A15Rik RIKEN cDNA 1810009A15 gene 1.40 NM_024461 1810037I17Rik RIKEN cDNA 1810037I17 gene 1.33 NM_001003405 1810049H19Rik RIKEN cDNA 1810049H19 gene 1.41 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 1.40 NM_133829 2210010L05Rik RIKEN cDNA 2210010L05 gene 1.35 NM_178081 2210010L05Rik RIKEN cDNA 2210010L05 gene 1.33 NM_027105 2310002B14Rik RIKEN cDNA 2310002B14 gene 1.57 NM_027104 2310002L09Rik RIKEN cDNA 2310002L09 gene 1.41 NM_183281 2310005G13Rik RIKEN cDNA 2310005G13 gene 1.35 NM_024460 2310016E02Rik RIKEN cDNA 2310016E02 gene 1.32 NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene 1.38 NM_197991 2310044H10Rik RIKEN cDNA 2310044H10 gene 1.57 NM_029747 2410137M14Rik RIKEN cDNA 2410137M14 gene 1.38 NM_029759 2410166I05Rik RIKEN cDNA 2410166I05 gene 1.40 NM_133729 2610018G03Rik RIKEN cDNA 2610018G03 gene 1.32 NM_183220 2610203E10Rik RIKEN cDNA 2610203E10 gene 1.57 NM_176835 2810451A06Rik RIKEN cDNA 2810451A06 gene 1.58 NM_175195 3110056O03Rik RIKEN cDNA 3110056O03 gene 1.42 NM_030167 4632404H22Rik RIKEN cDNA 4632404H22 gene 1.36 NM_177087 4632412N22Rik RIKEN cDNA 4632412N22 gene 1.40 NM_028725 4632417N05Rik RIKEN cDNA 4632417N05 gene 1.35 NM_145437 4732429D16Rik RIKEN cDNA 4732429D16 gene 1.37 NM_176987 4732471D19Rik RIKEN cDNA 4732471D19 gene 1.41 NM_198005 4833418A01Rik RIKEN cDNA 4833418A01 gene 1.33 NM_001033482 4833430A08Rik RIKEN cDNA 4833430A08 gene 1.36 NM_198655 4921509C19Rik RIKEN cDNA 4921509C19 gene 1.34 NM_026251 4930424G05Rik RIKEN cDNA 4930424G05 gene 1.39 NM_026248 4930430A15Rik RIKEN cDNA 4930430A15 gene 1.39

42 NM_029144 4930503B20Rik RIKEN cDNA 4930503B20 gene 1.44 NM_207527 4930504O13Rik RIKEN cDNA 4930504O13 gene 1.37 NM_029252 4930563D23Rik RIKEN cDNA 4930563D23 gene 1.51 NM_175672 4930579C12Rik RIKEN cDNA 4930579C12 gene 1.33 NM_027089 4930579C15Rik RIKEN cDNA 4930579C15 gene 1.42 NM_027631 4931407G18Rik RIKEN cDNA 4931407G18 gene 1.38 NM_001033764 4931408C20Rik RIKEN cDNA 4931408C20 gene 1.34 NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene 1.35 NM_172879 4932412H11Rik RIKEN cDNA 4932412H11 gene 1.34 NM_177841 4932418E24Rik RIKEN cDNA 4932418E24 gene 1.47 NM_001033775 4933422H20Rik RIKEN cDNA 4933422H20 gene 1.49 NM_026233 4933434I20Rik RIKEN cDNA 4933434I20 gene 1.43 NM_028964 4933437K13Rik RIKEN cDNA 4933437K13 gene 1.42 NM_001033424 5031408O05Rik RIKEN cDNA 5031408O05 gene 1.39 NM_175167 5430413K10Rik RIKEN cDNA 5430413K10 gene 1.46 NM_028666 5430432M24Rik RIKEN cDNA 5430432M24 gene 1.47 NM_172738 5730403M16Rik RIKEN cDNA 5730403M16 gene 1.33 NM_001013755 5730409E04Rik RIKEN cDNA 5730409E04Rik gene 1.47 NM_176976 5830418K08Rik RIKEN cDNA 5830418K08 gene 1.49 NM_178801 6030446N20Rik RIKEN cDNA 6030446N20 gene 1.32 NM_001039586 6230410P16Rik RIKEN cDNA 6230410P16 gene 1.43 NM_178745 6330442E10Rik RIKEN cDNA 6330442E10 gene 1.32 NM_177265 6330512M04Rik RIKEN cDNA 6330512M04 gene 1.35 NM_178689 6430537H07Rik RIKEN cDNA 6430537H07 gene 1.41 NM_175560 6430604K15Rik RIKEN cDNA 6430604K15 gene 1.39 NM_030135 8030411F24Rik RIKEN cDNA 8030411F24 gene 1.52 NM_177755 8230402K04Rik RIKEN cDNA 8230402K04 gene 1.36 NM_027834 9130008F23Rik RIKEN cDNA 9130008F23 gene 1.38 NM_029906 9530003J23Rik RIKEN cDNA 9530003J23 gene 1.34 NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene 1.41 NM_001002786 9830134C10Rik RIKEN cDNA 9830134C10 gene 1.37 NM_177194 A130023I24Rik RIKEN cDNA A130023I24 gene 1.48 NM_001033394 A230069A22Rik RIKEN cDNA A230069A22 gene 1.34 NM_001039721 A230107C01Rik RIKEN cDNA A230107C01 gene 1.41 NM_177624 A430083B19Rik RIKEN cDNA A430083B19 gene 1.33 NM_145969 A630054L15Rik RIKEN cDNA A630054L15 gene 1.41 NM_177669 A630098G03Rik RIKEN cDNA A630098G03 gene 1.64 NM_010661 A830036E02Rik RIKEN cDNA A830036E02 gene 1.42 NM_173425 A830043J08Rik RIKEN cDNA A830043J08 gene 1.34 NM_177182 A830053O21Rik RIKEN cDNA A830053O21 gene 1.40 NM_177118 A830073O21Rik RIKEN cDNA A830073O21 gene 1.48 NM_172795 A830091I15Rik RIKEN cDNA A830091I15 gene 1.84 NM_172379 AA536717 Expressed sequence AA536717 1.40 NM_001040106 Aak1 AP2 associated kinase 1 1.50 NM_009591 Aanat Arylalkylamine N-acetyltransferase 1.34 NM_146217 Aars Alanyl-tRNA synthetase 1.37 NM_178728 AB112350 CDNA sequence AB112350 1.56 NM_153145 Abca8a ATP-binding cassette, sub-family A (ABC1), member 8a 1.43 NM_011075 Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B 1.40 NM_008830 Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.35 NM_030239 Abcg3 ATP-binding cassette, sub-family G (WHITE), member 3 1.42 NM_001014399 Abi3bp ABI gene family, member 3 (NESH) binding protein 1.49 NM_029638 Abp1 Amiloride binding protein 1 (amine oxidase, -containing) 1.54 NM_183000 Accn3 Amiloride-sensitive cation channel 3 1.52 NM_012006 Acot1 Acyl-CoA thioesterase 1 1.32 NM_207668 Acpp Acid phosphatase, prostate 1.42 NM_146197 Acsm2 Acyl-CoA synthetase medium-chain family member 2 1.43 NM_025271 Actl7b Actin-like 7b 1.35

43 NM_033268 Actn2 Actinin alpha 2 1.45 NM_001033369 Acvr1c Activin A receptor, type IC 1.34 NM_009612 Acvrl1 Activin A receptor, type II-like 1 1.43 NM_172126 Adam1a A disintegrin and metallopeptidase domain 1a 1.33 NM_010086 Adam24 A disintegrin and metallopeptidase domain 24 (testase 1) 1.38 NM_011781 Adam25 A disintegrin and metallopeptidase domain 25 (testase 2) 1.34 NM_001025380 Adam39 A disintegrin and metallopeptidase domain 39 1.41 NM_007401 Adam5 A disintegrin and metallopeptidase domain 5 1.45 NM_007405 Adcy6 Adenylate cyclase 6 1.57 NM_001037724 Adcy7 Adenylate cyclase 7 1.37 NM_007416 Adra1b Adrenergic receptor, alpha 1b 1.36 NM_013462 Adrb3 Adrenergic receptor, beta 3 1.41 NM_009634 Adsl Adenylosuccinate lyase 1 1.39 NM_178803 Aebp2 AE binding protein 2 1.53 NM_153093 AF366264 CDNA sequence AF366264 1.35 NM_021604 Agrn Agrin 1.39 NM_001031851 Agxt2 -glyoxylate aminotransferase 2 1.35 NM_001033476 Ahnak2 AHNAK nucleoprotein 2 1.38 NM_001039220 AI429214 Expressed sequence AI429214 1.40 NM_199146 AI451617 Expressed sequence AI451617 1.33 NM_001013770 AI747699 Expressed sequence AI747699 1.35 NM_031185 Akap12 A kinase (PRKA) anchor protein (gravin) 12 1.42 NM_010241 Aktip Thymoma viral proto-oncogene 1 interacting protein 1.37 NM_019698 Aldh18a1 Aldehyde dehydrogenase 18 family, member A1 1.35 NM_178713 Aldh8a1 Aldehyde dehydrogenase 8 family, member A1 1.32 NM_053156 Allc 1.37 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 1.34 NM_153319 Amot Angiomotin 1.61 NM_001033303 Ampd1 Adenosine monophosphate deaminase 1 (isoform M) 1.33 NM_007446 Amy1 Amylase 1, salivary 1.49 NM_153502 Ankrd23 Ankyrin repeat domain 23 1.33 NM_144849 Ankrd54 Ankyrin repeat domain 54 1.60 NM_009672 Anp32a Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 1.35 NM_008486 Anpep Alanyl (membrane) aminopeptidase 1.43 NM_133738 Antxr2 Anthrax toxin receptor 2 1.43 NM_013472 Anxa6 A6 1.34 NM_012054 Aoah Acyloxyacyl hydrolase 1.48 NM_023617 Aox3 Aldehyde oxidase 3 1.39 NM_009678 Ap1m2 Adaptor protein complex AP-1, mu 2 subunit 1.35 NM_026674 Aph1c Anterior pharynx defective 1c homolog (C. elegans) 1.47 NM_007466 Api5 Apoptosis inhibitor 5 1.42 NM_007469 Apoc1 Apolipoprotein C-I 1.34 NM_009698 Aprt Adenine phosphoribosyl transferase 1.46 NM_177587 Aqp12 Aquaporin 12 1.62 NM_025445 Arfgap3 ADP-ribosylation factor GTPase activating protein 3 1.44 NM_001025377 Arhgap15 Rho GTPase activating protein 15 1.49 NM_027667 Arhgap19 Rho GTPase activating protein 19 1.36 NM_008488 Arhgef1 Rho guanine nucleotide exchange factor (GEF) 1 1.36 NM_172751 Arhgef10 Rho guanine nucleotide exchange factor (GEF) 10 1.37 NM_022992 Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 1.35 NM_001034858 Armc2 Armadillo repeat containing 2 1.42 NM_001037737 Arnt Aryl hydrocarbon receptor nuclear translocator 1.36 NM_172309 Arntl2 Aryl hydrocarbon receptor nuclear translocator-like 2 1.34 NM_019767 Arpc1a Actin related protein 2/3 complex, subunit 1A 1.36 NM_175731 Asah3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 1.49 NM_023729 Asz1 Ankyrin repeat, SAM and basic leucine zipper domain containing 1 1.42 NM_175650 Atp13a5 ATPase type 13A5 1.36 NM_016745 Atp2a3 ATPase, Ca++ transporting, ubiquitous 1.39

44 NM_177236 Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 1.51 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), NM_007506 Atp5g1 isoform 1 1.36 NM_027439 Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 1.34 NM_080467 Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 1.33 NM_033617 Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B 1.41 NM_133764 Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 1.37 NM_025494 Atp6v1c1 1.39 NM_139227 Atxn7 Ataxin 7 1.45 NM_177629 AU021034 Expressed sequence AU021034 1.33 NM_001035525 AU040320 Expressed sequence AU040320 1.35 NM_133359 AY026312 CDNA sequence AY026312 1.37 NM_001018019 AY616753 CDNA sequence, AY616753 1.52 NM_178084 B230120H23Rik RIKEN cDNA B230120H23 gene 1.42 NM_181278 B230219D22Rik RIKEN cDNA B230219D22 gene 1.36 NM_009735 B2m Beta-2 microglobulin 1.35 NM_178664 B3gntl1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 1.36 NM_198884 B4galnt3 Beta-1,4-N-acetyl-galactosaminyl transferase 3 1.39 NM_020579 B4galt3 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 1.36 NM_019804 B4galt4 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 1.41 NM_175312 B630005N14Rik RIKEN cDNA B630005N14 gene 1.37 NM_145601 BC016201 CDNA sequence BC016201 1.32 NM_145536 BC020535 CDNA sequence BC020535 1.53 NM_172611 BC021523 CDNA sequence BC021523 1.33 NM_001001489 BC021785 CDNA sequence BC021785 1.35 NM_177564 BC022224 CDNA sequence BC022224 1.43 NM_146004 BC024997 CDNA sequence BC024997 1.44 NM_172378 BC026439 CDNA sequence BC026439 1.32 NM_146149 BC026682 CDNA sequence BC026682 1.37 NM_182783 BC030183 CDNA sequence BC030183 1.37 NM_146249 BC031441 CDNA sequence BC031441 1.55 NM_001033364 BC040758 CDNA sequence BC040758 1.50 NM_001008549 BC043301 CDNA sequence BC043301 1.35 NM_177673 BC046331 CDNA sequence BC046331 1.33 NM_178414 BC048390 CDNA sequence BC048390 1.35 NM_173022 BC048403 CDNA sequence BC048403 1.33 NM_207524 BC049702 CDNA sequence BC049702 1.42 NM_183181 BC050777 CDNA sequence BC050777 1.34 NM_198301 BC052328 CDNA sequence BC052328 1.32 NM_199062 BC062127 CDNA sequence BC062127 1.33 NM_001013792 BC087945 CDNA sequence BC087945 1.35 NM_001001332 BC117090 CDNA sequence BC1179090 1.33 NM_009738 Bche 1.37 NM_009741 Bcl2 B-cell leukemia/lymphoma 2 1.37 NM_009746 Bcl7c B-cell CLL/lymphoma 7C 1.34 NM_030256 Bcl9l B-cell CLL/lymphoma 9-like 1.42 NM_008528 Blnk B-cell linker 1.32 NM_009756 Bmp10 Bone morphogenetic protein 10 1.48 NM_080708 Bmp2k BMP2 inducible kinase 1.38 NM_173404 Bmp3 Bone morphogenetic protein 3 1.35 NM_009759 Bmx BMX non-receptor tyrosine kinase 1.40 NM_001033274 Brd1 Bromodomain containing 1 1.41 NM_023336 Brd3 Bromodomain containing 3 1.36 NM_175235 Brunol6 Bruno-like 6, RNA binding protein (Drosophila) 1.50 NM_009763 Bst1 Bone marrow stromal cell antigen 1 1.53 NM_177110 C130023O10Rik RIKEN cDNA C130023O10 gene 1.34 NM_029920 C130038G02Rik RIKEN cDNA C130038G02 gene 1.50 NM_183175 C1qtnf9 C1q and tumor necrosis factor related protein 9 1.39 NM_178768 C230095G01Rik RIKEN cDNA C230095G01 gene 1.33

45 NM_194340 C330019G07Rik RIKEN cDNA C330019G07 gene 1.45 NM_009779 C3ar1 Complement component 3a receptor 1 1.53 NM_177351 C630028N24Rik RIKEN cDNA C630028N24 gene 1.38 NM_145368 C730036D15Rik RIKEN cDNA C730036D15 gene 1.35 NM_011274 C80913 Expressed sequence C80913 1.41 NM_133882 C8b Complement component 8, beta subunit 1.36 NM_013485 C9 Complement component 9 1.33 NM_027687 Cabyr Calcium-binding tyrosine-(Y)- regulated (fibrousheathin 2) 1.43 NM_026192 Calcoco1 Calcium binding and coiled coil domain 1 1.37 NM_018883 Camkk1 Calcium/-dependent protein kinase kinase 1, alpha 1.39 NM_007596 Caml Calcium modulating ligand 1.35 NM_026056 Cap2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.41 NM_001033444 Capn13 13 1.36 NM_007602 Capn5 Calpain 5 1.41 NM_178396 Car12 Carbonic anyhydrase 12 1.33 NM_009809 Casp14 Caspase 14 1.43 NM_139301 Catsper1 Cation channel of sperm 1 1.39 NM_007617 Cav3 1.36 NM_021609 Ccbp2 Chemokine binding protein 2 1.33 NM_025779 Ccdc109b Coiled-coil domain containing 109B 1.33 NM_175369 Ccdc122 Coiled-coil domain containing 122 1.50 NM_175430 Ccdc40 Coiled-coil domain containing 40 1.48 NM_001012309 Ccdc55 Coiled-coil domain containing 55 1.35 NM_177471 Ccdc69 Coiled-coil domain containing 69 1.46 NM_201372 Ccdc84 Coiled-coil domain containing 84 1.34 NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 1.41 NM_011888 Ccl19 Chemokine (C-C motif) ligand 19 1.35 NM_019577 Ccl24 Chemokine (C-C motif) ligand 24 1.45 NM_028399 Ccnt2 Cyclin T2 1.43 NM_007718 Ccr1l1 Chemokine (C-C motif) receptor 1-like 1 1.35 NM_009835 Ccr6 Chemokine (C-C motif) receptor 6 1.35 NM_017466 Ccrl2 Chemokine (C-C motif) receptor-like 2 1.43 NM_013486 Cd2 CD2 antigen 1.48 NM_018729 Cd244 CD244 receptor 2B4 1.35 NM_001033126 Cd27 CD antigen 27 1.38 NM_007642 Cd28 CD28 antigen 1.39 NM_134158 Cd300d Cd300D antigen 1.36 NM_025422 Cd302 CD302 antigen 1.35 NM_021293 Cd33 CD33 antigen 1.63 NM_007645 Cd37 CD37 antigen 1.34 NM_001033122 Cd69 CD69 antigen 1.57 NM_013489 Cd84 CD84 antigen 1.32 NM_009858 Cd8b1 CD8 antigen, beta chain 1 1.34 NM_023117 Cdc25b Cell division cycle 25 homolog B (S. pombe) 1.32 NM_009861 Cdc42 Cell division cycle 42 homolog (S. cerevisiae) 1.34 NM_021454 Cdc42ep5 CDC42 effector protein (Rho GTPase binding) 5 1.35 NM_009866 Cdh11 Cadherin 11 1.39 NM_172853 Cdh7 Cadherin 7, type 2 1.32 NM_145990 Cdk5rap2 CDK5 regulatory subunit associated protein 2 1.41 NM_007672 Cdr2 Cerebellar degeneration-related 2 1.33 NM_025496 Cdrt4 CMT1A duplicated region transcript 4 1.39 NM_173370 Cds1 CDP-diacylglycerol synthase 1 1.34 NM_144815 Cecr5 Cat eye syndrome chromosome region, candidate 5 homolog (human) 1.38 NM_177150 Cenpt Centromere protein T 1.35 NM_145603 Ces2 Carboxylesterase 2 1.46 NM_053200 Ces3 Carboxylesterase 3 1.51 NM_172759 Ces5 Carboxylesterase 5 1.45 NM_001003951 Ces7 Carboxylesterase 7 1.60

46 NM_007684 Cetn3 Centrin 3 1.32 NM_009889 Cga Glycoprotein hormones, alpha subunit 1.38 NM_009892 Chi3l3 Chitinase 3-like 3 1.66 NM_145126 Chi3l4 Chitinase 3-like 4 1.51 NM_007697 Chl1 Cell adhesion molecule with homology to L1CAM 1.34 NM_139134 Chodl Chondrolectin 1.38 NM_203491 Chrm2 Cholinergic receptor, muscarinic 2, cardiac 1.34 NM_007389 Chrna1 Cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) 1.33 NM_021439 Chst11 Carbohydrate sulfotransferase 11 1.47 NM_199055 Chst9 Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 1.43 NM_007575 Ciita Class II transactivator 1.32 NM_007705 Cirbp Cold inducible RNA binding protein 1.46 NM_173861 Ckt2 CKT2 protein 1.50 NM_009899 Clca1 Chloride channel calcium activated 1 1.36 NM_139148 Clca4 Chloride channel calcium activated 4 1.37 NM_020293 Cldn9 Claudin 9 1.34 NM_175526 Clec1a C-type lectin domain family 1, member a 1.36 NM_019985 Clec1b C-type lectin domain family 1, member b 1.33 NM_001007223 Clec3a C-type lectin domain family 3, member a 1.33 NM_199311 Clec4a1 C-type lectin domain family 4, member a1 1.53 NM_010819 Clec4d C-type lectin domain family 4, member d 1.54 NM_030179 Clip4 CAP-GLY domain containing linker protein family, member 4 1.42 NM_009907 Cln3 Ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) 1.38 NM_013748 Clnk Cytokine-dependent hematopoietic cell linker 1.47 NM_146047 Clptm1l CLPTM1-like 1.37 NM_178669 Clrn3 Clarin 3 1.34 NM_010780 Cma1 Chymase 1, mast cell 1.40 NM_001024714 Cma2 Chymase 2, mast cell 1.35 NM_009908 Cmas Cytidine monophospho-N-acetylneuraminic acid synthetase 1.40 NM_181588 Cmbl Carboxymethylenebutenolidase-like (Pseudomonas) 1.33 NM_053097 Cml3 Camello-like 3 1.36 NM_001037842 Cml3 Camello-like 3 1.34 NM_027022 Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 1.38 NM_024217 Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 1.38 NM_007723 Cnga1 Cyclic nucleotide gated channel alpha 1 1.46 NM_153585 Cnot10 CCR4-NOT transcription complex, subunit 10 1.38 NM_026562 Cntd1 Cyclin N-terminal domain containing 1 1.33 NM_025771 Cntnap2 Contactin associated protein-like 2 1.37 NM_009929 Col18a1 Procollagen, type XVIII, alpha 1 1.35 NM_007742 Col1a1 Procollagen, type I, alpha 1 1.49 NM_007743 Col1a2 Procollagen, type I, alpha 2 1.36 NM_027770 Col24a1 Procollagen, type XXIV, alpha 1 1.36 NM_146007 Col6a2 Procollagen, type VI, alpha 2 1.45 NM_025417 Commd4 COMM domain containing 4 1.32 NM_029635 Commd9 COMM domain containing 9 1.35 NM_175484 Coro2b Coronin, actin binding protein, 2B 1.37 NM_199008 Cox11 COX11 homolog, cytochrome c oxidase assembly protein (yeast) 1.70 NM_197980 Cox19 COX19 cytochrome c oxidase assembly homolog (S. cerevisiae) 1.32 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 1.40 NM_007752 Cp Ceruloplasmin 1.33 NM_007754 Cpd 1.48 NM_007759 Crabp2 Cellular retinoic acid binding protein II 1.52 NM_133239 Crb1 Crumbs homolog 1 (Drosophila) 1.37 NM_029720 Creld2 Cysteine-rich with EGF-like domains 2 1.34 NM_009953 Crhr2 Corticotropin releasing hormone receptor 2 1.35 NM_031402 Crispld1 Cysteine-rich secretory protein LCCL domain containing 1 1.37 NM_007770 Crx Cone-rod homeobox containing gene 1.39 NM_007776 Crygd Crystallin, gamma D 1.52

47 NM_016669 Crym Crystallin, mu 1.37 NM_007778 Csf1 Colony stimulating factor 1 (macrophage) 1.39 Colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte- NM_007781 Csf2rb2 macrophage) 1.34 NM_027874 Csnk1d , delta 1.39 NM_007791 Csrp1 Cysteine and glycine-rich protein 1 1.36 NM_030059 Cst11 Cystatin 11 1.36 NM_028836 Ctbs Chitobiase, di-N-acetyl- 1.37 NM_007802 Ctsk Cathepsin K 1.38 NM_177662 Ctso Cathepsin O 1.41 NM_175475 Cyp26b1 Cytochrome P450, family 26, subfamily b, polypeptide 1 1.32 NM_009997 Cyp2a4 Cytochrome P450, family 2, subfamily a, polypeptide 4 1.36 NM_007812 Cyp2a5 Cytochrome P450, family 2, subfamily a, polypeptide 5 1.37 NM_009999 Cyp2b10 Cytochrome P450, family 2, subfamily b, polypeptide 10 1.49 NM_010006 Cyp2d9 Cytochrome P450, family 2, subfamily d, polypeptide 9 1.37 NM_021282 Cyp2e1 Cytochrome P450, family 2, subfamily e, polypeptide 1 1.39 NM_013809 Cyp2g1 Cytochrome P450, family 2, subfamily g, polypeptide 1 1.37 NM_007820 Cyp3a16 Cytochrome P450, family 3, subfamily a, polypeptide 16 1.57 NM_017396 Cyp3a41a Cytochrome P450, family 3, subfamily a, polypeptide 41A 1.37 NM_010011 Cyp4a10 Cytochrome P450, family 4, subfamily a, polypeptide 10 1.35 NM_130882 Cyp4f13 Cytochrome P450, family 4, subfamily f, polypeptide 13 1.38 NM_024444 Cyp4f18 Cytochrome P450, family 4, subfamily f, polypeptide 18 1.51 NM_008455 Cyp4v3 Cytochrome P450, family 4, subfamily v, polypeptide 3 1.44 NM_001003947 Cyp4x1 Cytochrome P450, family 4, subfamily x, polypeptide 1 1.41 NM_020010 Cyp51 Cytochrome P450, family 51 1.37 NM_010012 Cyp8b1 Cytochrome P450, family 8, subfamily b, polypeptide 1 1.39 NM_001004455 Cys1 Cystin 1 1.49 NM_177640 D030056L22Rik RIKEN cDNA D030056L22 gene 1.40 NM_198420 D15Wsu169e DNA segment, Chr 15, Wayne State University 169, expressed 1.33 NM_033077 D1Pas1 DNA segment, Chr 1, Pasteur Institute 1 1.37 NM_172573 D230014K01Rik RIKEN cDNA D230014K01 gene 1.34 NM_172727 D330028D13Rik RIKEN cDNA D330028D13 gene 1.36 NM_175326 D330045A20Rik RIKEN cDNA D330045A20 gene 1.34 NM_019995 D3Ertd300e DNA segment, Chr 3, ERATO Doi 300, expressed 1.33 NM_026821 D4Bwg0951e DNA segment, Chr 4, Brigham & Women's Genetics 0951 expressed 1.49 NM_001025608 D4Ertd22e DNA segment, Chr 4, ERATO Doi 22, expressed 1.36 NM_001033385 D630037F22Rik RIKEN cDNA D630037F22 gene 1.33 NM_026585 D6Wsu116e DNA segment, Chr 6, Wayne State University 116, expressed 1.33 NM_138594 D6Wsu163e DNA segment, Chr 6, Wayne State University 163, expressed 1.36 NM_172911 D8Ertd82e DNA segment, Chr 8, ERATO Doi 82, expressed 1.32 NM_173420 D930020E02Rik RIKEN cDNA D930020E02 gene 1.35 NM_172921 D930028F11Rik RIKEN cDNA D930028F11 gene 1.40 NM_010045 Darc Duffy blood group, 1.41 NM_001037999 Dbi Diazepam binding inhibitor 1.40 NM_031403 Dbr1 Debranching enzyme homolog 1 (S. cerevisiae) 1.44 NM_025705 Dcbld1 Discoidin, CUB and LCCL domain containing 1 1.53 NM_010027 Ddt D-dopachrome tautomerase 1.36 NM_199080 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 1.35 NM_181324 Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 1.34 NM_139225 Defb10 Defensin beta 10 1.36 NM_010030 Defb2 Defensin beta 2 1.39 NM_001039122 Defb25 Defensin beta 25 1.36 NM_183038 Defb39 Defensin beta 39 1.41 NM_139220 Defb7 Defensin beta 7 1.32 NM_153108 Defb8 Defensin beta 8 1.36 NM_028110 Dennd2d DENN/MADD domain containing 2D 1.50 NM_178683 Depdc1b DEP domain containing 1B 1.48 NM_001037937 Depdc6 DEP domain containing 6 1.34 NM_016811 Dgka Diacylglycerol kinase, alpha 1.47

48 NM_030150 Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 1.35 NM_007860 Dio1 Deiodinase, iodothyronine, type I 1.63 NM_170593 Disp2 Dispatched homolog 2 (Drosophila) 1.38 NM_020265 Dkk2 Dickkopf homolog 2 (Xenopus laevis) 1.48 Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate NM_030225 Dlst complex) 1.61 DMC1 dosage suppressor of mck1 homolog, -specific homologous NM_010059 Dmc1 recombination (yeast)disrupted meiotic cDNA 1 1.42 NM_183312 Dmn Desmuslin 1.46 NM_133365 Dnahc5 Dynein, axonemal, heavy chain 5 1.35 NM_001034878 Dnaic2 Dynein, axonemal, intermediate chain 2 1.41 NM_018808 Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.49 NM_008299 Dnajb3 DnaJ (Hsp40) homolog, subfamily B, member 3 1.36 NM_020566 Dnajc4 DnaJ (Hsp40) homolog, subfamily C, member 4 1.33 NM_010061 Dnase1 1.37 NM_007870 Dnase1l3 Deoxyribonuclease 1-like 3 1.59 NM_010066 Dnmt1 DNA methyltransferase (cytosine-5) 1 1.33 NM_133763 Dnttip1 Deoxynucleotidyltransferase, terminal, interacting protein 1 1.38 NM_153413 Dock3 Dedicator of cyto-kinesis 3 1.38 NM_177030 Dedicator of cytokinesis 6 1.65 NM_053246 Dok4 Docking protein 4 1.33 NM_199322 Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) 1.33 NM_010074 Dpp4 Dipeptidylpeptidase 4 1.41 NM_178247 Dppa1 Developmental pluripotency associated 1 1.34 NM_007877 Drd3 3 1.40 NM_010087 Dtna alpha 1.34 NM_001013826 Dupd1 Dual specificity phosphatase and pro isomerase domain containing 1 1.37 NM_022019 Dusp10 Dual specificity phosphatase 10 1.38 NM_153459 Dusp7 Dual specificity phosphatase 7 1.34 NM_001025384 DXBay18 DNA segment, Chr X, Baylor 18 1.37 NM_025975 Dynlt3 Dynein light chain Tctex-type 3 1.60 NM_001038651 E130120F12Rik RIKEN cDNA E130120F12 gene 1.33 NM_001013784 E130309D14Rik RIKEN cDNA E130309D14 gene 1.44 NM_178609 E2f7 E2F transcription factor 7 1.41 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 1.36 NM_024208 Echdc3 Enoyl Coenzyme A hydratase domain containing 3 1.35 NM_023060 Eefsec Eukaryotic elongation factor, selenocysteine-tRNA-specific 1.33 NM_144511 EG13909 Predicted gene, EG13909 1.50 NM_177593 EG210155 Predicted gene, EG210155 1.34 NM_001033767 EG240327 Predicted gene, EG240327 1.34 NM_001013764 EG244595 Predicted gene, EG244595 1.45 NM_001004158 EG380907 Predicted gene, EG380907 1.48 NM_001004162 EG432436 Predicted gene, EG432436 1.42 NM_001004168 EG432723 Predicted gene, EG432723 1.32 NM_001004182 EG434008 Predicted gene, EG434008 1.35 NM_001034892 EG434510 Predicted gene, EG434510 1.41 NM_001013824 EG435337 Predicted gene, EG435337 1.35 NM_001034894 EG436240 Predicted gene, EG436240 1.79 NM_001024709 EG544710 Predicted gene, EG544710 1.33 NM_001039243 EG632778 Predicted gene, EG632778 1.42 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) 1.39 NM_010118 Egr2 Early growth response 2 1.46 NM_172265 Eif2b5 Eukaryotic translation initiation factor 2B, subunit 5 epsilon 1.48 NM_018749 Eif3d Eukaryotic translation initiation factor 3, subunit D 1.47 NM_001039170 Eif4e2 Eukaryotic translation initiation factor 4E member 2 1.42 NM_023479 Elac2 ElaC homolog 2 (E. coli) 1.45 NM_010485 Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 1.47 NM_207705 Elmo2 Engulfment and cell motility 2, ced-12 homolog (C. elegans) 1.37 NM_139138 Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 1.45

49 NM_001025388 Eno1 Enolase 1, alpha non-neuron 1.33 NM_001030291 Enpp7 Ectonucleotide pyrophosphatase/phosphodiesterase 7 1.45 NM_134065 Epdr1 Ependymin related protein 1 () 1.37 NM_010141 Epha7 Eph receptor A7 1.34 NM_173447 Ephb1 Eph receptor B1 1.32 NM_133867 Eps8l3 ESP8-like 3 1.39 NM_007946 Epx Eosinophil peroxidase 1.53 Excision repair cross-complementing repair deficiency complementation NM_146235 Ercc6l group 6 - like 1.37 NM_153592 Erlin2 ER lipid raft associated 2 1.34 NM_023154 Ethe1 Ethylmalonic encephalopathy 1 1.37 NM_012012 Exo1 1 1.39 NM_007969 Expi Extracellular proteinase inhibitor 1.35 NM_010162 Ext1 Exostoses (multiple) 1 1.39 NM_028066 F11 Coagulation factor XI 1.40 NM_010170 F2rl2 Coagulation factor II (thrombin) receptor-like 2 1.33 NM_177653 F830045P16Rik RIKEN cDNA F830045P16 gene 1.42 NM_017399 Fabp1 Fatty acid binding protein 1, 1.46 NM_008375 Fabp6 Fatty acid binding protein 6, ileal (gastrotropin) 1.36 NM_010176 Fah Fumarylacetoacetate hydrolase 1.35 NM_027123 Fastkd3 FAST kinase domains 3 1.49 NM_015793 Fbxw14 F-box and WD-40 domain protein 14 1.34 NM_013907 Fbxw4 F-box and WD-40 domain protein 4 1.41 NM_010189 Fcgrt Fc receptor, IgG, alpha chain transporter 1.33 NM_178165 Fcrl1 Fc receptor-like 1 1.36 NM_145141 Fcrla Fc receptor-like A 1.41 NM_001029984 Fcrlb Fc receptor-like B 1.39 NM_183171 Fez1 Fasciculation and elongation protein zeta 1 (zygin I) 1.44 NM_015759 Fgd3 FYVE, RhoGEF and PH domain containing 3 1.32 NM_139233 Fgd4 FYVE, RhoGEF and PH domain containing 4 1.49 NM_172731 Fgd5 FYVE, RhoGEF and PH domain containing 5 1.42 NM_054071 Fgfrl1 Fibroblast growth factor receptor-like 1 1.33 NM_008013 Fgl2 -like protein 2 1.51 NM_010210 Fhit Fragile histidine triad gene 1.34 NM_010212 Fhl2 Four and a half LIM domains 2 1.32 NM_010221 Fkbp10 FK506 binding protein 10 1.34 NM_010219 Fkbp4 FK506 binding protein 4 1.36 NM_001040403 Flot2 Flotillin 2 1.40 NM_008031 Fmr1 Fragile X mental retardation syndrome 1 homolog 1.34 NM_145927 Fntb Farnesyltransferase, CAAX box, beta 1.38 NM_008021 Foxm1 Forkhead box M1 1.45 NM_053202 Foxp1 Forkhead box P1 1.36 NM_175473 Fras1 Fraser syndrome 1 homolog (human) 1.38 NM_172475 Frmd4a FERM domain containing 4A 1.34 NM_172673 Frmd5 FERM domain containing 5 1.54 homolog 3, actin-bundling protein, testicular (Strongylocentrotus NM_019569 Fscn3 purpuratus) 1.36 NM_008047 Fstl1 Follistatin-like 1 1.74 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 1.33 NM_028058 Fundc1 FUN14 domain containing 1 1.39 NM_008761 Fxyd5 FXYD domain-containing ion transport regulator 5 1.35 NM_008054 Fyn Fyn proto-oncogene 1.44 NM_008055 Fzd4 Frizzled homolog 4 (Drosophila) 1.34 NM_019757 Fzr1 Fizzy/cell division cycle 20 related 1 (Drosophila) 1.34 NM_010250 Gabra1 Gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1 1.41 NM_001033416 Gal3st4 Galactose-3-O-sulfotransferase 4 1.33 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_026449 Galntl5 acetylgalactosaminyltransferase-like 5 1.34 NM_015738 Galr3 Galanin receptor 3 1.43

50 NM_008083 Gap43 Growth associated protein 43 1.38 NM_001033331 Gas2l3 Growth arrest-specific 2 like 3 1.36 NM_139197 Gbgt1 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 1.37 NM_008100 Gcg Glucagon 1.37 NM_008112 Gdi2 Guanosine diphosphate (GDP) dissociation inhibitor 2 1.38 NM_177696 Gdpd4 Glycerophosphodiester phosphodiesterase domain containing 4 1.39 NM_201352 Gdpd5 Glycerophosphodiester phosphodiesterase domain containing 5 1.32 NM_013529 Gfpt2 fructose-6-phosphate transaminase 2 1.35 NM_008116 Ggt1 Gamma-glutamyltransferase 1 1.41 NM_144786 Ggtl3 Gamma-glutamyltransferase-like 3 1.47 NM_011820 Ggtla1 Gamma-glutamyltransferase-like activity 1 1.36 NM_146167 Gimap7 GTPase, IMAP family member 7 1.32 NM_008120 Gja4 Gap junction membrane channel protein alpha 4 1.38 NM_175459 Glis3 GLIS family zinc finger 3 1.45 NM_175681 Glp2r Glucagon-like peptide 2 receptor 1.39 NM_177005 Glt1d1 Glycosyltransferase 1 domain containing 1 1.33 NM_198612 Glt8d4 Glycosyltransferase 8 domain containing 4 1.61 NM_001033473 Gm1157 Gene model 1157, (NCBI) 1.34 NM_001033452 Gm1967 Gene model 1967, (NCBI) 1.45 NM_001033345 Gm216 Gene model 216, (NCBI) 1.42 NM_001033333 Gm239 Gene model 239, (NCBI) 1.37 NM_001033362 Gm614 Gene model 614, (NCBI) 1.61 NM_001033252 Gm732 Gene model 732, (NCBI) 1.43 NM_001033423 Gm773 Gene model 773, (NCBI) 1.32 NM_001033234 Gm9 Gene model 9, (NCBI) 1.52 NM_001004061 Gm93 Gene model 93, (NCBI) 1.37 NM_001033448 Gm962 Gene model 962, (NCBI) 1.38 NM_025277 Gng10 Guanine nucleotide binding protein (G protein), gamma 10 1.33 Guanine nucleotide binding protein (G protein), gamma transducing activity NM_023121 Gngt2 polypeptide 2 1.46 NM_010321 Gnmt Glycine N-methyltransferase 1.45 NM_175193 Golim4 Golgi integral 4 1.35 NM_027352 Gorasp2 Golgi reassembly stacking protein 2 1.36 NM_029674 Got1l1 Glutamic-oxaloacetic transaminase 1-like 1 1.35 NM_010326 Gp1ba Glycoprotein 1b, alpha polypeptide 1.43 NM_008149 Gpam Glycerol-3-phosphate acyltransferase, mitochondrial 1.44 NM_008156 Gpld1 Glycosylphosphatidylinositol specific phospholipase D1 1.36 NM_001033493 Gpr111 G protein-coupled receptor 111 1.50 NM_181752 Gpr135 G protein-coupled receptor 135 1.51 NM_001024138 Gpr139 G protein-coupled receptor 139 1.35 NM_030258 Gpr146 G protein-coupled receptor 146 1.40 NM_026582 Gpr177 G protein-coupled receptor 177 1.50 NM_008159 Gpr33 G protein-coupled receptor 33 1.43 NM_022320 Gpr35 G protein-coupled receptor 35 1.46 NM_178712 Gpr64 G protein-coupled receptor 64 1.50 NM_008152 Gpr65 G-protein coupled receptor 65 1.35 NM_030720 Gpr84 G protein-coupled receptor 84 1.44 NM_080289 Grhpr Glyoxylate reductase/hydroxypyruvate reductase 1.38 NM_019497 Grk4 G protein-coupled receptor kinase 4 1.32 NM_011938 Grk6 G protein-coupled receptor kinase 6 1.40 NM_008174 Grm8 , metabotropic 8 1.45 NM_008177 Grpr Gastrin releasing peptide receptor 1.38 NM_010359 Gstm3 Glutathione S-transferase, mu 3 1.32 NM_026764 Gstm4 Glutathione S-transferase, mu 4 1.32 NM_001039519 Gtf2a2 General transcription factor II A, 2 1.39 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 1.37 NM_025332 Gtpbp8 GTP-binding protein 8 (putative) 1.38 NM_145067 Gucy2c 1.40 NM_010374 Gzmf Granzyme F 1.37

51 NM_010375 Gzmg Granzyme G 1.39 NM_177923 H2-M10.2 Histocompatibility 2, M region locus 10.2 1.37 NM_201608 H2-M10.3 Histocompatibility 2, M region locus 10.3 1.44 NM_177635 H2-M11 Histocompatibility 2, M region locus 11 1.43 NM_008204 H2-M2 Histocompatibility 2, M region locus 2 1.40 NM_008205 H2-M9 Histocompatibility 2, M region locus 9 1.44 NM_008206 H2-Oa Histocompatibility 2, O region alpha locus 1.43 NM_146101 Habp2 Hyaluronic acid binding protein 2 1.35 NM_024284 Hagh Hydroxyacyl 1.48 NM_134250 Havcr2 Hepatitis A virus cellular receptor 2 1.32 NM_010410 Hcrt Hypocretin 1.43 NM_011827 Hcst Hematopoietic cell signal transducer 1.45 NM_144919 Hdac11 Histone deacetylase 11 1.36 NM_033041 Hes7 Hairy and enhancer of split 7 (Drosophila) 1.50 NM_010420 Hesx1 Homeo box gene expressed in ES cells 1.36 NM_013547 Hgd Homogentisate 1, 2-dioxygenase 1.51 NM_010431 Hif1a Hypoxia inducible factor 1, alpha subunit 1.43 NM_010377 Hist1h1t Histone cluster 1, H1t 1.34 NM_175660 Hist1h2ab Histone cluster 1, H2ab 1.42 NM_175655 Hist1h4f Histone cluster 1, H4f 1.35 NM_013820 Hk2 Hexokinase 2 1.33 Holocarboxylase synthetase (- [propriony-Coenzyme A-carboxylase (ATP- NM_139145 Hlcs hydrolysing)] ) 1.32 NM_008252 Hmgb2 High mobility group box 2 1.36 NM_173731 Hmgcll1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 1.39 NM_009330 Hnf1b HNF1 homeobox B 1.37 NM_198090 Hnrpa3 Heterogeneous nuclear ribonucleoprotein A3 1.40 NM_010450 Hoxa11 Homeo box A11 1.56 NM_010453 Hoxa5 Homeo box A5 1.38 NM_017371 Hpx Hemopexin 1.51 NM_008294 Hsd3b4 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 1.41 NM_001002012 Hspa2 Heat shock protein 2 1.32 NM_008310 Htr1f 5-hydroxytryptamine (serotonin) receptor 1F 1.34 NM_172812 Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 1.34 NM_028752 Hvcn1 Hydrogen voltage-gated channel 1 1.35 NM_008317 Hyal1 Hyaluronoglucosaminidase 1 1.41 NM_010489 Hyal2 Hyaluronoglucosaminidase 2 1.34 NM_008318 Ibsp Integrin binding sialoprotein 1.33 NM_177197 Idi2 Isopentenyl-diphosphate delta isomerase 2 1.38 NM_008329 Ifi204 Interferon activated gene 204 1.37 NM_172648 Ifi205 Interferon activated gene 205 1.34 NM_133871 Ifi44 Interferon-induced protein 44 1.43 NM_026820 Ifitm1 Interferon induced transmembrane protein 1 1.37 NM_010505 Ifna5 Interferon alpha 5 1.33 NM_008341 Igfbp1 Insulin-like growth factor binding protein 1 1.35 NM_010518 Igfbp5 Insulin-like growth factor binding protein 5 1.43 NM_008048 Igfbp7 Insulin-like growth factor binding protein 7 1.49 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 1.46 NM_010546 Ikbkb Inhibitor of kappaB kinase beta 1.34 NM_019777 Ikbke Inhibitor of kappaB kinase epsilon 1.37 NM_011770 Ikzf2 IKAROS family zinc finger 2 1.48 NM_010548 Il10 1.35 NM_010550 Il11ra2 Interleukin 11 receptor, alpha chain 2 1.35 NM_010551 Il16 Interleukin 16 1.34 NM_010743 Il1rl1 Interleukin 1 receptor-like 1 1.40 NM_001039701 Il1rn Interleukin 1 receptor antagonist 1.33 NM_008366 Il2 Interleukin 2 1.37 NM_053095 Il24 1.34 NM_008368 Il2rb Interleukin 2 receptor, beta chain 1.36

52 NM_010556 Il3 1.43 NM_178241 Il8ra Interleukin 8 receptor, alpha 1.38 NM_023343 Ilkap Integrin-linked kinase-associated serine/threonine phosphatase 2C 1.36 NM_008380 Inhba Inhibin beta-A 1.33 NM_008384 Inpp1 Inositol polyphosphate-1-phosphatase 1.40 NM_001024617 Inpp4b Inositol polyphosphate-4-phosphatase, type II 1.35 NM_008386 Ins1 Insulin I 1.44 NM_027927 Ints12 Integrator complex subunit 12 1.46 NM_178632 Ints7 Integrator complex subunit 7 1.44 NM_010569 Invs Inversin 1.34 NM_177128 Iqcb1 IQ calmodulin-binding motif containing 1 1.36 NM_022655 Ireb2 Iron responsive element binding protein 2 1.35 NM_001029872 Itgad Integrin, alpha D 1.42 NM_008399 Itgae Integrin, alpha E, epithelial-associated 1.40 NM_008401 Itgam Integrin alpha M 1.39 NM_021334 Itgax 1.35 NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 1.33 NM_010587 Itsn1 Intersectin 1 (SH3 domain protein 1A) 1.33 NM_001039511 Ivns1abp Influenza virus NS1A binding protein 1.40 NM_173441 Iws1 IWS1 homolog (S. cerevisiae) 1.35 NM_021878 Jarid2 Jumonji, AT rich interactive domain 2 1.43 NM_172382 Jmjd2a Jumonji domain containing 2A 1.42 NM_030887 Jundm2 Jun dimerization protein 2 1.62 NM_028805 Katnb1 Katanin p80 (WD40-containing) subunit B 1 1.36 NM_019931 Kcnd3 Potassium voltage-gated channel, Shal-related family, member 3 1.47 NM_008430 Kcnk1 Potassium channel, subfamily K, member 1 1.42 NM_207261 Kcnk18 Potassium channel, subfamily K, member 18 1.33 NM_021542 Kcnk5 Potassium channel, subfamily K, member 5 1.45 NM_010616 Kif12 Kinesin family member 12 1.40 NM_177757 Kif26b Kinesin family member 26B 1.53 NM_134471 Kif2c Kinesin family member 2C 1.35 NM_008445 Kif3c Kinesin family member 3C 1.42 NM_025280 Kin Antigenic determinant of rec-A protein 1.33 NM_178260 Kiss1 KiSS-1 metastasis-suppressor 1.46 NM_173780 Klf8 Kruppel-like factor 8 1.37 NM_053105 Klhl1 Kelch-like 1 (Drosophila) 1.34 NM_178771 Klhl26 Kelch-like 26 (Drosophila) 1.44 NM_001033531 Klhl32 Kelch-like 32 (Drosophila) 1.37 NM_133203 Klra17 Killer cell lectin-like receptor, subfamily A, member 17 1.34 NM_010653 Klrc2 Killer cell lectin-like receptor subfamily C, member 2 1.60 NM_033373 Krt23 Keratin 23 1.33 NM_010665 Krt32 Keratin 32 1.34 NM_027983 Krt33a Keratin 33A 1.48 NM_213730 Krt39 Keratin 39 1.51 NM_008475 Krt4 Keratin 4 1.35 NM_001003667 Krt77 Keratin 77 1.33 NM_025720 Krtap3-2 Keratin associated protein 3-2 1.43 NM_025524 Krtap3-3 Keratin associated protein 3-3 1.34 NM_010672 Krtap6-1 Keratin associated protein 6-1 1.36 NM_026304 l7Rn6 Lethal, Chr 7, Rinchik 6 1.37 NM_133892 Lao1 L-amino acid oxidase 1 1.39 NM_172856 Lass6 Longevity assurance homolog 6 (S. cerevisiae) 1.56 NM_020044 Lat2 Linker for activation of T cells family, member 2 1.34 NM_008489 Lbp Lipopolysaccharide binding protein 1.32 NM_028625 Lce1a2 Late cornified envelope 1A2 1.38 NM_028622 Lce1c Late cornified envelope 1C 1.37 NM_025413 Lce1g Late cornified envelope 1G 1.39 NM_025420 Lce1m Late cornified envelope 1M 1.51

53 NM_178886 Ldlrad3 Low density lipoprotein receptor class A domain containing 3 1.38 NM_010701 Lect1 Leukocyte cell derived chemotaxin 1 1.37 NM_026609 Leprotl1 receptor overlapping transcript-like 1 1.43 NM_010708 Lgals9 Lectin, galactose binding, soluble 9 1.34 NM_013584 Lifr Leukemia inhibitory factor receptor 1.35 NM_013860 Limd1 LIM domains containing 1 1.34 NM_144862 Lims2 LIM and senescent cell antigen like domains 2 1.33 NM_021460 Lipa Lysosomal acid lipase A 1.37 NM_008280 Lipc Lipase, hepatic 1.35 NM_008502 Llgl1 Lethal giant larvae homolog 1 (Drosophila) 1.51 NM_207222 Lmo3 LIM domain only 3 1.36 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 1.33 NM_001039646 LOC626578 Macrophage activation 2 like LOC626578 1.37 NM_033325 Loxl2 Lysyl oxidase-like 2 1.40 NM_028233 Lrpprc Leucine-rich PPR-motif containing 1.36 NM_026825 Lrrc16 Leucine rich repeat containing 16 1.37 NM_145152 Lrrc3 Leucine rich repeat containing 3 1.42 NM_001033346 Lrrc55 Leucine rich repeat containing 55 1.46 NM_177093 Lrrc58 Leucine rich repeat containing 58 1.33 NM_178701 Lrrc8d Leucine rich repeat containing 8D 1.44 NM_019391 Lsp1 Lymphocyte specific 1 1.38 NM_017405 Lsr stimulated lipoprotein receptor 1.34 NM_010738 Ly6a Lymphocyte antigen 6 complex, locus A 1.33 NM_010741 Ly6c1 Lymphocyte antigen 6 complex, locus C1 1.47 NM_008530 Ly6f Lymphocyte antigen 6 complex, locus F 1.33 NM_023463 Ly6g6c Lymphocyte antigen 6 complex, locus G6C 1.45 NM_033478 Ly6g6d Lymphocyte antigen 6 complex, locus G6D 1.52 NM_013825 Ly75 Lymphocyte antigen 75 1.41 NM_029610 Lyrm1 LYR motif containing 1 1.34 NM_153121 Lysmd1 LysM, putative peptidoglycan-binding, domain containing 1 1.37 NM_027309 Lysmd2 LysM, putative peptidoglycan-binding, domain containing 2 1.34 NM_053247 Lyve1 Lymphatic vessel endothelial hyaluronan receptor 1 1.35 NM_026963 Lzic Leucine zipper and CTNNBIP1 domain containing 1.44 NM_199364 Lzts1 Leucine zipper, putative tumor suppressor 1 1.37 NM_001013802 Macrod2 MACRO domain containing 2 1.40 NM_020017 Magea3 Melanoma antigen, family A, 3 1.38 NM_031171 Mageb2 Melanoma antigen, family B, 2 1.52 NM_026345 Mansc1 MANSC domain containing 1 1.41 NM_019920 Map2k1ip1 Mitogen-activated protein kinase kinase 1 interacting protein 1 1.39 NM_011948 Map3k4 Mitogen activated protein kinase kinase kinase 4 1.44 NM_001003913 Mars Methionine-tRNA synthetase 1.39 NM_212447 Marveld3 MARVEL (membrane-associating) domain containing 3 1.41 NM_010770 Matn3 Matrilin 3 1.33 NM_025676 Mcm8 Minichromosome maintenance deficient 8 (S. cerevisiae) 1.33 NM_173189 Mcph1 Microcephaly, primary autosomal recessive 1 1.34 NM_010786 Mdm2 Transformed mouse 3T3 cell double minute 2 1.54 NM_001029890 Mex3a Mex3 homolog A (C. elegans) 1.42 NM_015776 Mfap5 Microfibrillar associated protein 5 1.37 NM_172499 Mfsd9 Major facilitator superfamily domain containing 9 1.52 NM_010795 Mgat3 Mannoside acetylglucosaminyltransferase 3 1.34 NM_145926 Mgat4b Mannoside acetylglucosaminyltransferase 4, isoenzyme B 1.45 NM_145128 Mgat5 Mannoside acetylglucosaminyltransferase 5 1.39 NM_001017393 MGC107098 Similar to spermiogenesis specific transcript on the Y 2 1.38 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 1.44 NM_008597 Mgp Matrix Gla protein 1.34 NM_177321 Mia2 Melanoma inhibitory activity 2 1.45 NM_010798 Mif Macrophage migration inhibitory factor 1.38 NM_008600 Mip Major intrinsic protein of eye fiber 1.58

54 NM_026143 Mlstd2 Male sterility domain containing 2 1.33 NM_032007 Mmp1b Matrix metallopeptidase 1b (interstitial collagenase) 1.34 NM_010808 Mmp24 Matrix metallopeptidase 24 1.33 NM_001033450 Mnda Myeloid cell nuclear differentiation antigen 1.61 NM_010813 Mnt Max binding protein 1.63 NM_001039364 Mobp Myelin-associated oligodendrocytic basic protein 1.54 NM_172610 Mpped1 Metallophosphoesterase domain containing 1 1.50 NM_008209 Mr1 Major histocompatibility complex, class I-related 1.39 NM_008624 Mras Muscle and microspikes RAS 1.42 NM_026154 Mrpl10 Mitochondrial ribosomal protein L10 1.44 NM_025553 Mrpl11 Mitochondrial ribosomal protein L11 1.39 NM_026732 Mrpl14 Mitochondrial ribosomal protein L14 1.63 NM_011288 Mrpl23 Mitochondrial ribosomal protein L23 1.47 NM_027098 Mrpl30 Mitochondrial ribosomal protein L30 1.38 NM_025500 Mrpl37 Mitochondrial ribosomal protein L37 1.41 NM_025474 Mrps14 Mitochondrial ribosomal protein S14 1.45 NM_026080 Mrps24 Mitochondrial ribosomal protein S24 1.56 NM_021556 Mrps30 Mitochondrial ribosomal protein S30 1.44 NM_017391 Mrps6 Mitochondrial ribosomal protein S6 1.33 NM_025658 Ms4a4d Membrane-spanning 4-domains, subfamily A, member 4D 1.35 NM_027209 Ms4a6b Membrane-spanning 4-domains, subfamily A, member 6B 1.68 NM_030707 Msr2 Macrophage scavenger receptor 2 1.47 NM_008630 Mt2 Metallothionein 2 1.37 NM_177293 Mtap7d3 MAP7 domain containing 3 1.82 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent), NM_138745 Mthfd1 methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase 1.52 NM_133767 Mtif2 Mitochondrial translational initiation factor 2 1.33 NM_026849 Mtmr14 Myotubularin related protein 14 1.33 NM_028860 Mtmr3 Myotubularin related protein 3 1.54 NM_145712 Mtnr1b receptor 1B 1.35 NM_008644 Muc10 Mucin 10, submandibular gland salivary mucin 1.33 NM_181729 Muc6 Mucin 6, gastric 1.41 NM_008649 Mup5 Major urinary protein 5 1.33 NM_010859 Myl3 , light polypeptide 3 1.34 NM_010867 Myom1 Myomesin 1 1.37 NM_133363 Myoz3 Myozenin 3 1.34 NM_172690 N28178 Expressed sequence N28178 1.33 NM_028279 Naalad2 N-acetylated alpha-linked acidic 1.34 NM_138671 Nadk NAD kinase 1.45 NM_019542 Nagk N-acetylglucosamine kinase 1.37 NM_053089 Narg1 NMDA receptor-regulated gene 1 1.34 NM_010874 Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 1.39 NM_153505 Nckap1l NCK associated protein 1 like 1.45 NM_010881 Ncoa1 Nuclear receptor coactivator 1 1.36 NM_144892 Ncoa5 Nuclear receptor coactivator 5 1.51 NM_023317 Nde1 Nuclear distribution gene E homolog 1 (A nidulans) 1.36 NM_023668 Ndel1 Nuclear distribution gene E-like homolog 1 (A. nidulans) 1.52 NM_026612 Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 1.37 NM_017464 Nedd9 Neural precursor cell expressed, developmentally down-regulated gene 9 1.32 NM_199465 Nexn Nexilin 1.41 NM_028728 Nfam1 Nfat activating molecule with ITAM motif 1 1.38 NM_010903 Nfe2l3 Nuclear factor, erythroid derived 2, like 3 1.36 NM_010914 Nfyb Nuclear transcription factor-Y beta 1.35 NM_022414 Ngb Neuroglobin 1.40 NM_033217 Ngfr Nerve growth factor receptor (TNFR superfamily, member 16) 1.35 NM_173390 Nhsl1 NHS-like 1 1.35 NM_175532 Nlrp10 NLR family, pyrin domain containing 10 1.33 NM_001004194 Nlrp4e NLR family, pyrin domain containing 4E 1.38 NM_021315 Noc3l Nucleolar complex associated 3 homolog (S. cerevisiae) 1.41

55 NM_181345 Npm2 Nucleophosmin/nucleoplasmin 2 1.33 NM_020282 Nqo2 NAD(P)H dehydrogenase, quinone 2 1.34 NM_013839 Nr1h3 Nuclear receptor subfamily 1, group H, member 3 1.57 NM_139051 Nr5a1 Nuclear receptor subfamily 5, group A, member 1 1.41 NM_022029 Nrgn Neurogranin 1.38 NM_015807 Nt5c 5',3'-nucleotidase, cytosolic 1.34 NM_133500 Ntng2 Netrin G2 1.34 NM_001004363 Nuak1 NUAK family, SNF1-like kinase, 1 1.43 NM_011955 Nubp1 Nucleotide binding protein 1 1.37 NM_016773 Nucb2 Nucleobindin 2 1.33 NM_025399 Nudt14 Nudix (nucleoside diphosphate linked moiety X)-type motif 14 1.42 NM_033080 Nudt19 Nudix (nucleoside diphosphate linked moiety X)-type motif 19 1.37 NM_016918 Nudt5 Nudix (nucleoside diphosphate linked moiety X)-type motif 5 1.39 NM_028794 Nudt9 Nudix (nucleoside diphosphate linked moiety X)-type motif 9 1.41 NM_145209 Oasl1 2'-5' oligoadenylate synthetase-like 1 1.36 NM_008757 Odf1 Outer dense fiber of sperm tails 1 1.38 NM_001011721 Olfr100 Olfactory receptor 100 1.33 NM_146570 Olfr1006 Olfactory receptor 1006 1.35 NM_146569 Olfr1014 Olfactory receptor 1014 1.39 NM_001011774 Olfr1028 Olfactory receptor 1028 1.37 NM_146588 Olfr1030 Olfactory receptor 1030 1.52 NM_207561 Olfr1040 Olfactory receptor 1040 1.45 NM_146577 Olfr1043 Olfactory receptor 1043 1.45 NM_147017 Olfr1045 Olfactory receptor 1045 1.36 NM_001011744 Olfr105 Olfactory receptor 105 1.38 NM_147078 Olfr1062 Olfactory receptor 1062 1.36 NM_146591 Olfr1101 Olfactory receptor 1101 1.32 NM_146593 Olfr1111 Olfactory receptor 1111 1.39 NM_147031 Olfr1122 Olfactory receptor 1122 1.36 NM_146637 Olfr1141 Olfactory receptor 1141 1.44 NM_146632 Olfr116 Olfactory receptor 116 1.36 NM_146531 Olfr1168 Olfactory receptor 1168 1.38 NM_146823 Olfr1184 Olfactory receptor 1184 1.38 NM_001005227 Olfr1200 Olfactory receptor 1200 1.38 NM_147062 Olfr124 Olfactory receptor 124 1.38 NM_146808 Olfr1240 Olfactory receptor 1240 1.37 NM_146978 Olfr1258 Olfactory receptor 1258 1.54 NM_146981 Olfr1260 Olfactory receptor 1260 1.40 NM_146980 Olfr1272 Olfactory receptor 1272 1.40 NM_146393 Olfr1279 Olfactory receptor 1279 1.34 NM_207236 Olfr1283 Olfactory receptor 1283 1.35 NM_001011773 Olfr1287 Olfactory receptor 1287 1.43 NM_146402 Olfr1303 Olfactory receptor 1303 1.39 NM_146867 Olfr131 Olfactory receptor 131 1.33 NM_207703 Olfr1335 Olfactory receptor 1335 1.32 NM_146915 Olfr1336 Olfactory receptor 1336 1.35 NM_146309 Olfr1337 Olfactory receptor 1337 1.35 NM_146832 Olfr134 Olfactory receptor 134 1.40 NM_146853 Olfr1341 Olfactory receptor 1341 1.45 NM_146713 Olfr1342 Olfactory receptor 1342 1.48 NM_146916 Olfr1346 Olfactory receptor 1346 1.44 NM_146385 Olfr1347 Olfactory receptor 1347 1.37 NM_146543 Olfr1360 Olfactory receptor 1360 1.33 NM_146283 Olfr1366 Olfactory receptor 1366 1.43 NM_146469 Olfr1381 Olfactory receptor 1381 1.35 NM_147065 Olfr1390 Olfactory receptor 1390 1.35 NM_146276 Olfr1394 Olfactory receptor 1394 1.33 NM_146763 Olfr1406 Olfactory receptor 1406 1.41

56 NM_001011524 Olfr1418 Olfactory receptor 1418 1.41 NM_146984 Olfr142 Olfactory receptor 142 1.50 NM_146680 Olfr1423 Olfactory receptor 1423 1.60 NM_146679 Olfr1427 Olfactory receptor 1427 1.39 NM_146414 Olfr1431 Olfactory receptor 1431 1.39 NM_001011839 Olfr1437 Olfactory receptor 1437 1.43 NM_207665 Olfr144 Olfactory receptor 144 1.32 NM_146683 Olfr1441 Olfactory receptor 1441 1.34 NM_146698 Olfr1443 Olfactory receptor 1443 1.40 NM_146701 Olfr1448 Olfactory receptor 1448 1.36 NM_146689 Olfr1459 Olfactory receptor 1459 1.36 NM_207132 Olfr1471 Olfactory receptor 1471 1.42 NM_001011831 Olfr1500 Olfactory receptor 1500 1.39 NM_146634 Olfr1504 Olfactory receptor 1504 1.43 NM_146265 Olfr1506 Olfactory receptor 1506 1.33 NM_207664 Olfr151 Olfactory receptor 151 1.54 NM_013728 Olfr154 Olfactory receptor 154 1.32 NM_008763 Olfr16 Olfactory receptor 16 1.33 NM_146357 Olfr168 Olfactory receptor 168 1.32 NM_147000 Olfr173 Olfactory receptor 173 1.42 NM_146322 Olfr187 Olfactory receptor 187 1.37 NM_146992 Olfr204 Olfactory receptor 204 1.33 NM_001011801 Olfr213 Olfactory receptor 213 1.45 NM_001001809 Olfr218 Olfactory receptor 218 1.33 NM_146606 Olfr24 Olfactory receptor 24 1.37 NM_146607 Olfr270 Olfactory receptor 270 1.57 NM_146457 Olfr282 Olfactory receptor 282 1.41 NM_146281 Olfr284 Olfactory receptor 284 1.39 NM_146500 Olfr319 Olfactory receptor 319 1.33 NM_010980 Olfr32 Olfactory receptor 32 1.34 NM_146879 Olfr330 Olfactory receptor 330 1.45 NM_001011770 Olfr332 Olfactory receptor 332 1.46 NM_146942 Olfr351 Olfactory receptor 351 1.40 NM_147024 Olfr378 Olfactory receptor 378 1.35 NM_146710 Olfr398 Olfactory receptor 398 1.34 NM_147004 Olfr399 Olfactory receptor 399 1.44 NM_146295 Olfr446 Olfactory receptor 446 1.42 NM_146445 Olfr450 Olfactory receptor 450 1.41 NM_146987 Olfr457 Olfactory receptor 457 1.41 NM_146412 Olfr464 Olfactory receptor 464 1.32 NM_010990 Olfr48 Olfactory receptor 48 1.44 NM_146732 Olfr488 Olfactory receptor 488 1.45 NM_146914 Olfr5 Olfactory receptor 5 1.40 NM_001011846 Olfr517 Olfactory receptor 517 1.33 NM_146306 Olfr518 Olfactory receptor 518 1.34 NM_147063 Olfr520 Olfactory receptor 520 1.38 NM_146519 Olfr530 Olfactory receptor 530 1.48 NM_146953 Olfr531 Olfactory receptor 531 1.46 NM_001011815 Olfr533 Olfactory receptor 533 1.47 NM_001011867 Olfr538 Olfactory receptor 538 1.33 NM_146962 Olfr541 Olfactory receptor 541 1.35 NM_147115 Olfr578 Olfactory receptor 578 1.41 NM_147111 Olfr586 Olfactory receptor 586 1.38 NM_001011847 Olfr591 Olfactory receptor 591 1.36 NM_001011793 Olfr598 Olfactory receptor 598 1.37 NM_147082 Olfr609 Olfactory receptor 609 1.32 NM_146964 Olfr61 Olfactory receptor 61 1.46 NM_147081 Olfr610 Olfactory receptor 610 1.44

57 NM_147080 Olfr615 Olfactory receptor 615 1.42 NM_146315 Olfr62 Olfactory receptor 62 1.35 NM_146959 Olfr631 Olfactory receptor 631 1.47 NM_146813 Olfr651 Olfactory receptor 651 1.48 NM_147074 Olfr653 Olfactory receptor 653 1.48 NM_146820 Olfr655 Olfactory receptor 655 1.35 NM_147060 Olfr667 Olfactory receptor 667 1.37 NM_147043 Olfr669 Olfactory receptor 669 1.38 NM_001011755 Olfr671 Olfactory receptor 671 1.42 NM_147044 Olfr679 Olfactory receptor 679 1.47 NM_147069 Olfr686 Olfactory receptor 686 1.39 NM_147032 Olfr705 Olfactory receptor 705 1.34 NM_146601 Olfr710 Olfactory receptor 710 1.33 NM_146780 Olfr715 Olfactory receptor 715 1.32 NM_146862 Olfr763 Olfactory receptor 763 1.32 NM_130866 Olfr78 Olfactory receptor 78 1.37 NM_146729 Olfr784 Olfactory receptor 784 1.34 NM_207147 Olfr813 Olfactory receptor 813 1.44 NM_146871 Olfr898 Olfactory receptor 898 1.51 NM_146787 Olfr920 Olfactory receptor 920 1.39 NM_146782 Olfr921 Olfactory receptor 921 1.37 NM_001011813 Olfr93 Olfactory receptor 93 1.45 NM_146326 Olfr943 Olfactory receptor 943 1.40 NM_146507 Olfr944 Olfactory receptor 944 1.38 NM_146514 Olfr96 Olfactory receptor 96 1.46 NM_146279 Olfr960 Olfactory receptor 960 1.34 NM_146286 Olfr981 Olfactory receptor 981 1.40 NM_146854 Olfr982 Olfactory receptor 982 1.62 NM_146827 Olfr983 Olfactory receptor 983 1.41 NM_146608 Olfr984 Olfactory receptor 984 1.43 NM_146855 Olfr985 Olfactory receptor 985 1.39 NM_178657 Oog1 Oogenesin 1 1.41 NM_133353 Oosp1 Oocyte secreted protein 1 1.33 NM_013887 Opn4 Opsin 4 (melanopsin) 1.40 NM_011012 Oprl1 Opioid receptor-like 1 1.43 NM_145517 Ormdl1 ORM1-like 1 (S. cerevisiae) 1.40 NM_145525 Osbpl6 Oxysterol binding protein-like 6 1.33 NM_001013783 OTTMUSG00000005491 Predicted gene, OTTMUSG00000005491 1.34 NM_001039223 OTTMUSG00000015762 Predicted gene, OTTMUSG00000015762 1.33 NM_001025574 OTTMUSG00000015915 Predicted gene, OTTMUSG00000015915 1.51 NM_001040055 OTTMUSG00000016293 Predicted gene, OTTMUSG00000016293 1.35 NM_007696 Ovgp1 Oviductal glycoprotein 1 1.38 NM_001001490 Oxgr1 Oxoglutarate (alpha-ketoglutarate) receptor 1 1.50 NM_001008497 P2ry14 P2Y, G-protein coupled, 14 1.43 Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), NM_011031 P4ha2 alpha II polypeptide 1.51 NM_053182 Pag1 Phosphoprotein associated with glycosphingolipid microdomains 1 1.51 NM_008777 Pah hydroxylase 1.37 NM_011039 Pax7 Paired box gene 7 1.36 NM_020005 Pcaf P300/CBP-associated factor 1.33 Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte NM_025273 Pcbd1 nuclear factor 1 alpha (TCF1) 1 1.40 NM_021543 Pcdh8 Protocadherin 8 1.34 NM_201243 Pcdha11 Protocadherin alpha 11 1.34 NM_053140 Pcdhb15 Protocadherin beta 15 1.35 NM_033586 Pcdhga12 Protocadherin gamma subfamily A, 12 1.37 NM_033589 Pcdhga12 Protocadherin gamma subfamily A, 12 1.35 NM_033582 Pcdhga12 Protocadherin gamma subfamily A, 12 1.48 NM_023662 Pcm1 Pericentriolar material 1 1.34

58 NM_175561 Pcnxl2 Pecanex-like 2 (Drosophila) 1.36 NM_021396 Pdcd1lg2 Programmed cell death 1 ligand 2 1.35 NM_026549 Pdcd2l Programmed cell death 2-like 1.34 NM_011050 Pdcd4 Programmed cell death 4 1.47 NM_153422 Pde5a Phosphodiesterase 5A, cGMP-specific 1.48 NM_146086 Pde6a Phosphodiesterase 6A, cGMP-specific, rod, alpha 1.43 NM_033614 Pde6c Phosphodiesterase 6C, cGMP specific, cone, alpha prime 1.36 NM_012065 Pde6g Phosphodiesterase 6G, cGMP-specific, rod, gamma 1.35 NM_013875 Pde7b Phosphodiesterase 7B 1.38 NM_019501 Pdss1 Prenyl (solanesyl) diphosphate synthase, subunit 1 1.34 NM_001032378 Pecam1 Platelet/endothelial cell adhesion molecule 1 1.35 NM_008820 Pepd Peptidase D 1.33 NM_023041 Pex19 Peroxisome biogenesis factor 19 1.50 NM_018870 Pgam2 2 1.48 NM_199317 Phf16 PHD finger protein 16 1.32 NM_177201 Phf8 PHD finger protein 8 1.46 NM_172453 Pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 1.44 NM_031376 Pik3ap1 Phosphoinositide-3-kinase adaptor protein 1 1.37 NM_177320 Pik3r5 Phosphoinositide-3-kinase, regulatory subunit 5, p101 1.33 NM_008845 Pip4k2a Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 1.43 NM_011089 Pira2 Paired-Ig-like receptor A2 1.40 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 1.38 NM_177905 Piwil4 Piwi-like homolog 4 (Drosophila) 1.35 NM_011107 Pla2g1b Phospholipase A2, group IB, pancreas 1.50 NM_016915 Pla2g6 Phospholipase A2, group VI 1.51 NM_001037634 Plac1l Placenta-specific 1-like 1.39 NM_008872 Plat Plasminogen activator, tissue 1.69 NM_148937 Plcd4 Phospholipase C, delta 4 1.34 NM_177355 Plcxd3 Phosphatidylinositol-specific phospholipase C, X domain containing 3 1.33 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 1.34 NM_011136 Pou2af1 POU domain, class 2, associating factor 1 1.57 NM_015817 Ppap2c Phosphatidic acid phosphatase type 2c 1.39 NM_008014 Ppm1g Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 1.43 NM_028292 Ppme1 Protein phosphatase methylesterase 1 1.34 NM_133485 Ppp1r14c Protein phosphatase 1, regulatory (inhibitor) subunit 14c 1.45 NM_172420 Ppp1r1c Protein phosphatase 1, regulatory (inhibitor) subunit 1C 1.55 NM_021529 Ppp2r3c Protein phosphatase 2, regulatory subunit B'', gamma 1.50 NM_008914 Ppp3cb Protein phosphatase 3, catalytic subunit, beta isoform 1.46 NM_008915 Ppp3cc Protein phosphatase 3, catalytic subunit, gamma isoform 1.34 NM_182939 Ppp4r2 Protein phosphatase 4, regulatory subunit 2 1.33 NM_025861 Pqlc1 PQ loop repeat containing 1 1.37 NM_172574 Pqlc3 PQ loop repeat containing 1.35 NM_007453 Prdx6 Peroxiredoxin 6 1.43 NM_177256 Prdx6-rs1 Peroxiredoxin 6, related sequence 1 1.34 NM_016703 Preb Prolactin regulatory element binding 1.45 NM_054077 Prelp Proline arginine-rich end leucine-rich repeat 1.36 NM_008923 Prkar1b Protein kinase, cAMP dependent regulatory, type I beta 1.41 NM_011103 Prkcd Protein kinase C, delta 1.38 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 1.44 NM_008930 Prl7a1 Prolactin family 7, subfamily a, member 1 1.39 NM_019830 Prmt1 Protein arginine N-methyltransferase 1 1.34 NM_008934 Proc 1.34 NM_138659 Prpf8 Pre-mRNA processing factor 8 1.38 NM_178774 Prr18 Proline rich region 18 1.38 NM_028447 Prrc1 Proline-rich coiled-coil 1 1.51 NM_009430 Prss2 Protease, serine, 2 1.40 NM_019412 Prx Periaxin 1.40 NM_011181 Pscd2 Pleckstrin homology, Sec7 and coiled-coil domains 2 1.40

59 NM_177611 Psd4 Pleckstrin and Sec7 domain containing 4 1.39 NM_011966 Psma4 Proteasome (prosome, macropain) subunit, alpha type 4 1.35 NM_025959 Psmc6 Proteasome (prosome, macropain) 26S subunit, ATPase, 6 1.35 NM_026545 Psmd8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 1.34 NM_011189 Psme1 Proteasome (prosome, macropain) 28 subunit, alpha 1.38 NM_008961 Pter Phosphotriesterase related 1.35 NM_008970 Pthlh Parathyroid hormone-like peptide 1.34 NM_009184 Ptk6 PTK6 protein tyrosine kinase 6 1.33 NM_008977 Ptpn2 Protein tyrosine phosphatase, non-receptor type 2 1.36 NM_008978 Ptpn20 Protein tyrosine phosphatase, non-receptor type 20 1.36 NM_013643 Ptpn5 Protein tyrosine phosphatase, non-receptor type 5 1.35 NM_029928 Ptprb Protein tyrosine phosphatase, receptor type, B 1.34 NM_008982 Ptprj Protein tyrosine phosphatase, receptor type, J 1.50 NM_178595 Ptrh1 Peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) 1.49 NM_013917 Pttg1 Pituitary tumor-transforming 1 1.35 NM_013645 Pvalb Parvalbumin 1.33 NM_008990 Pvrl2 Poliovirus receptor-related 2 1.32 NM_021534 Pxmp4 Peroxisomal membrane protein 4 1.48 NM_175026 Pyhin1 Pyrin and HIN domain family, member 1 1.46 NM_021888 Qtrt1 Queuine tRNA-ribosyltransferase 1 1.58 NM_029128 Qtrtd1 Queuine tRNA-ribosyltransferase domain containing 1 1.37 NM_025887 Rab5a RAB5A, member RAS oncogene family 1.40 NM_010261 Rabac1 Rab acceptor 1 (prenylated) 1.38 NM_009007 Rac1 RAS-related C3 botulinum substrate 1 1.42 NM_009015 Rad54l RAD54 like (S. cerevisiae) 1.40 NM_009020 Rag2 Recombination activating gene 2 1.33 NM_009021 Rai1 Retinoic acid induced 1 1.42 NM_001037764 Rai1 Retinoic acid induced 1 1.42 NM_019444 Ramp2 Receptor (calcitonin) activity modifying protein 2 1.32 NM_023146 Ranbp17 RAN binding protein 17 1.33 NM_175258 Rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 1.43 NM_198302 Rbm11 RNA binding motif protein 11 1.53 NM_030243 Rbm43 RNA binding motif protein 43 1.44 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 1.49 NM_009034 Rbp2 Retinol binding protein 2, cellular 1.48 NM_133878 Rcc1 Regulator of chromosome condensation 1 1.35 NM_026555 Rcn3 Reticulocalbin 3, EF-hand calcium binding domain 1.63 NM_030017 Rdh12 Retinol dehydrogenase 12 1.38 NM_025654 Rdm1 RAD52 motif 1 1.45 NM_139292 Reep6 Receptor accessory protein 6 1.33 NM_009042 Reg1 Regenerating islet-derived 1 1.39 NM_145923 Rell1 RELT-like 1 1.50 NM_153793 Rell2 RELT-like 2 1.44 NM_009049 Resp18 Regulated endocrine-specific protein 18 1.35 NM_011258 Rfc1 Replication factor C (activator 1) 1 1.38 NM_133231 Rfxap Regulatory factor X-associated protein 1.35 NM_177740 Rgma RGM domain family, member A 1.33 NM_026418 Rgs10 Regulator of G-protein signalling 10 1.45 NM_019958 Rgs17 Regulator of G-protein signaling 17 1.41 NM_029777 Rhbdd1 Rhomboid domain containing 1 1.35 NM_023275 Rhoj Ras homolog gene family, member J 1.42 NM_201236 Rhox4e Reproductive homeobox 4E 1.43 NM_001039698 Rhox4h Reproductive homeobox 4H 1.45 NM_183172 Ric8b Resistance to inhibitors of 8 homolog B (C. elegans) 1.33 NM_019955 Ripk3 Receptor-interacting serine-threonine kinase 3 1.32 NM_024288 Rmnd5a Required for meiotic nuclear division 5 homolog A (S. cerevisiae) 1.33 NM_029145 Rnase10 Ribonuclease, RNase A family, 10 (non-active) 1.41 NM_026616 Rnaseh2c Ribonuclease H2, subunit C 1.42

60 NM_016698 Rnf10 Ring finger protein 10 1.51 NM_009543 Rnf103 Ring finger protein 103 1.32 NM_027445 Rnf167 Ring finger protein 167 1.32 NM_011884 Rngtt RNA and 5'-phosphatase 1.34 NM_009070 Rnps1 Ribonucleic acid binding protein S1 1.32 NM_030744 Ropn1 Ropporin, rhophilin associated protein 1 1.48 NM_011285 Rpgr GTPase regulator 1.36 NM_026533 Rps13 Ribosomal protein S13 1.37 NM_011300 Rps7 Ribosomal protein S7 1.38 NM_028040 Rpusd4 RNA pseudouridylate synthase domain containing 4 1.40 NM_025846 Rras2 Related RAS viral (r-ras) oncogene homolog 2 1.34 NM_130892 Rtn4ip1 Reticulon 4 interacting protein 1 1.33 NM_016759 Rundc3a RUN domain containing 3A 1.34 NM_203507 Rwdd4a RWD domain containing 4A 1.51 NM_080468 Rxfp2 Relaxin/insulin-like family peptide receptor 2 1.42 NM_009109 Ryr1 1, 1.34 NM_025393 S100a14 S100 calcium binding protein A14 1.36 NM_009118 Sag Retinal S-antigen 1.35 NM_177225 Samd12 Sterile alpha motif domain containing 12 1.48 NM_022028 Sav1 Salvador homolog 1 (Drosophila) 1.35 NM_172205 Sbsn Suprabasin 1.36 NM_007644 Scarb2 Scavenger receptor class B, member 2 1.34 NM_178653 Sccpdh dehydrogenase (putative) 1.33 NM_178672 Scfd2 Sec1 family domain containing 2 1.44 NM_001014761 Scn2b Sodium channel, voltage-gated, type II, beta 1.32 NM_133199 Scn4a Sodium channel, voltage-gated, type IV, alpha 1.32 NM_133704 Sec22a SEC22 vesicle trafficking protein-like A (S. cerevisiae) 1.34 NM_172596 Sec24c SEC24 related gene family, member C (S. cerevisiae) 1.34 NM_145373 Sectm1a Secreted and transmembrane 1A 1.36 NM_011346 Sell Selectin, lymphocyte 1.34 NM_011347 Selp Selectin, platelet 1.35 Sema domain, seven thrombospondin repeats (type 1 and type 1-like), NM_013661 Sema5b transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 1.33 Sema domain, transmembrane domain (TM), and cytoplasmic domain, NM_199238 Sema6d (semaphorin) 6D 1.50 NM_023475 Serhl -like 1.62 NM_173024 Serpina3b Serine (or cysteine) peptidase inhibitor, clade A, member 3B 1.36 NM_008458 Serpina3c Serine (or cysteine) peptidase inhibitor, clade A, member 3C 1.50 Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, NM_027997 Serpina9 antitrypsin), member 9 1.36 NM_027971 Serpinb12 Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12 1.40 NM_173052 Serpinb1b Serine (or cysteine) peptidase inhibitor, clade B, member 1b 1.36 NM_080844 Serpinc1 Serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 1.42 NM_053099 Setbp1 SET binding protein 1 1.43 NM_177386 Sfmbt2 Scm-like with four mbt domains 2 1.37 NM_009160 Sftpd Surfactant associated protein D 1.37 NM_001037759 Sgk3 Serum/glucocorticoid regulated kinase 3 1.52 NM_139302 Sh3glb2 SH3-domain GRB2-like endophilin B2 1.41 NM_172788 Sh3md4 SH3 multiple domains 4 1.35 NM_177364 Sh3pxd2b SH3 and PX domains 2B 1.34 NM_009168 Shd Src homology 2 domain-containing transforming protein D 1.33 NM_011376 Sim1 Single-minded homolog 1 (Drosophila) 1.36 NM_153567 Slain2 SLAIN motif family, member 2 1.69 NM_144539 Slamf7 SLAM family member 7 1.38 NM_029612 Slamf9 SLAM family member 9 1.42 NM_009195 Slc12a4 Solute carrier family 12, member 4 1.54 NM_053079 Slc15a1 Solute carrier family 15 (oligopeptide transporter), member 1 1.36 NM_009198 Slc17a1 Solute carrier family 17 (sodium phosphate), member 1 1.36 NM_134069 Slc17a3 Solute carrier family 17 (sodium phosphate), member 3 1.33

61 NM_177016 Slc17a4 Solute carrier family 17 (sodium phosphate), member 4 1.44 NM_146255 Slc1a7 Solute carrier family 1 (glutamate transporter), member 7 1.37 NM_001037749 Slc22a14 Solute carrier family 22 (organic cation transporter), member 14 1.42 Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), NM_007451 Slc25a5 member 5 1.38 NM_174870 Slc26a1 Solute carrier family 26 (sulfate transporter), member 1 1.38 NM_021353 Slc26a3 Solute carrier family 26, member 3 1.63 NM_177243 Slc26a9 Solute carrier family 26, member 9 1.40 NM_146257 Slc29a4 Solute carrier family 29 (nucleoside transporters), member 4 1.45 NM_011401 Slc2a3 Solute carrier family 2 (facilitated glucose transporter), member 3 1.45 NM_009204 Slc2a4 Solute carrier family 2 (facilitated glucose transporter), member 4 1.37 NM_019741 Slc2a5 Solute carrier family 2 (facilitated glucose transporter), member 5 1.35 NM_172816 Slc30a8 Solute carrier family 30 (zinc transporter), member 8 1.35 NM_134060 Slc35b3 Solute carrier family 35, member B3 1.45 NM_001033219 Slc45a4 Solute carrier family 45, member 4 1.34 NM_001033227 Slc5a10 Solute carrier family 5 (sodium/glucose cotransporter), member 10 1.40 NM_144852 Slc7a4 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 1.42 NM_021471 Slco1c1 Solute carrier organic anion transporter family, member 1c1 1.36 NM_033314 Slco2a1 Solute carrier organic anion transporter family, member 2a1 1.37 NM_175316 Slco2b1 Solute carrier organic anion transporter family, member 2b1 1.47 NM_198864 Slitrk3 SLIT and NTRK-like family, member 3 1.40 NM_028534 Smap1 Stromal membrane-associated protein 1 1.32 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, NM_025891 Smarcd3 subfamily d, member 3 1.35 NM_008017 Smc2 Structural maintenance of 2 1.40 NM_001039889 Smok3b Sperm motility kinase 3B 1.45 NM_021491 Smpd3 Sphingomyelin , neutral 1.38 NM_024230 Smtnl1 Smoothelin-like 1 1.45 NM_026408 Sncaip Synuclein, alpha interacting protein (synphilin) 1.43 NM_028035 Snx10 Sorting nexin 10 1.34 NM_178362 Sorbs1 Sorbin and SH3 domain containing 1 1.44 NM_011366 Sorbs3 Sorbin and SH3 domain containing 3 1.39 NM_130458 Sp7 Trans-acting transcription factor 7 1.47 NM_153115 Spag11 Sperm associated antigen 11 1.42 NM_027649 Spats1 Spermatogenesis associated, serine-rich 1 1.47 NM_029048 Spdyb Speedy homolog B (Drosophila) 1.33 NM_026457 Spert Spermatid associated 1.34 NM_025721 Spesp1 Sperm equatorial segment protein 1 1.36 NM_020011 Sphk2 2 1.39 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 1.33 NM_009258 Spink3 Serine peptidase inhibitor, Kazal type 3 1.39 NM_172287 Spire2 Spire homolog 2 (Drosophila) 1.36 NM_013675 Spnb1 beta 1 1.38 NM_009262 Spock1 Sparc/, cwcv and kazal-like domains proteoglycan 1 1.45 NM_009263 Spp1 Secreted phosphoprotein 1 1.42 NM_009265 Sprr1b Small proline-rich protein 1B 1.35 NM_011474 Sprr2h Small proline-rich protein 2H 1.48 NM_011477 Sprr2k Small proline-rich protein 2K 1.33 NM_011478 Sprr3 Small proline-rich protein 3 1.42 NM_009270 Sqle Squalene epoxidase 1.39 NM_020611 Srd5a2l Steroid 5 alpha-reductase 2-like 1.77 NM_016795 Srpk1 Serine/arginine-rich protein specific kinase 1 1.35 NM_019684 Srpk3 Serine/arginine-rich protein specific kinase 3 1.33 NM_016911 Srpx Sushi-repeat-containing protein 1.34 NM_199063 Ssx9 Synovial sarcoma, X breakpoint 9 1.54 NM_199319 Ssxb5 Synovial sarcoma, X member B, breakpoint 5 1.39 NM_018784 St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 1.36 NM_145838 St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 1.33 NM_016853 Stac Src homology three (SH3) and cysteine rich domain 1.34

62 NM_177707 Stac3 SH3 and cysteine rich domain 3 1.45 NM_026474 Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 1.48 NM_133670 Sult1a1 Sulfotransferase family 1A, phenol-preferring, member 1 1.38 NM_026935 Sult1c2 Sulfotransferase family, cytosolic, 1C, member 2 1.40 NM_153153 Svil Supervillin 1.32 NM_021363 Svs3a Seminal vesicle secretion 3A 1.45 NM_011517 Sycp3 Synaptonemal complex protein 3 1.33 NM_018803 Syt10 Synaptotagmin X 1.47 NM_031395 Sytl3 Synaptotagmin-like 3 1.36 NM_028769 Syvn1 Synovial apoptosis inhibitor 1, synoviolin 1.35 NM_001010840 Taar8c Trace amine-associated receptor 8C 1.49 NM_199153 Tas2r102 Taste receptor, type 2, member 102 1.39 NM_207011 Tas2r104 Taste receptor, type 2, member 104 1.57 NM_207028 Tas2r126 Taste receptor, type 2, member 126 1.32 NM_199159 Tas2r135 Taste receptor, type 2, member 135 1.33 NM_181275 Tas2r139 Taste receptor, type 2, member 139 1.42 NM_001001453 Tas2r144 Taste receptor, type 2, member 144 1.51 NM_181516 Taz 1.58 NM_145952 Tbc1d12 TBC1D12: TBC1 domain family, member 12 1.37 NM_025935 Tbc1d7 TBC1 domain family, member 7 1.32 NM_025289 Tbrg1 Transforming growth factor beta regulated gene 1 1.33 NM_011545 Tcf21 Transcription factor 21 1.44 NM_031198 Tcfec Transcription factor EC 1.49 NM_029992 Tchp Trichoplein, keratin filament binding 1.32 NM_011562 Tdgf1 Teratocarcinoma-derived growth factor 1.38 NM_198418 Tdrd6 Tudor domain containing 6 1.49 NM_009348 Tectb Tectorin beta 1.32 NM_027880 Telo2 TEL2, telomere maintenance 2, homolog (S. cerevisiae) 1.33 NM_009354 Tert 1.54 NM_207176 Tes Testis derived transcript 1.37 NM_009355 Tesp1 Testicular serine protease 1 1.36 NM_009356 Tesp2 Testicular serine protease 2 1.33 NM_031384 Tex11 Testis expressed gene 11 1.36 NM_031374 Tex15 Testis expressed gene 15 1.37 NM_028602 Tex19 Testis expressed gene 19 1.46 NM_198292 Tex2 Testis expressed gene 2 1.36 NM_028799 Tgm5 Transglutaminase 5 1.59 NM_020580 Th1l TH1-like homolog (Drosophila) 1.40 NM_026909 Thap7 THAP domain containing 7 1.37 NM_011583 Theg Testicular haploid expressed gene 1.34 NM_009381 Thrsp Thyroid hormone responsive SPOT14 homolog (Rattus) 1.39 NM_019576 Thsd1 Thrombospondin, type I, domain 1 1.46 NM_178646 Tigd5 Tigger transposable element derived 5 1.32 NM_019818 Timm22 Translocase of inner mitochondrial membrane 22 homolog (yeast) 1.42 NM_011904 Tll2 Tolloid-like 2 1.44 NM_145539 Tm4sf4 Transmembrane 4 superfamily member 4 1.41 NM_080556 Tm9sf2 Transmembrane 9 superfamily member 2 1.34 NM_025458 Tmed6 Transmembrane emp24 protein transport domain containing 6 1.49 NM_001033393 Tmem104 Transmembrane protein 104 1.42 NM_025480 Tmem128 Transmembrane protein 128 1.33 NM_144801 Tmem143 Transmembrane protein 143 1.61 NM_029398 Tmem14a Transmembrane protein 14A 1.36 NM_144916 Tmem150 Transmembrane protein 150 1.45 NM_011626 Tmem165 Transmembrane protein 165 1.46 NM_153589 Tmem16b Transmembrane protein 16B 1.51 NM_177694 Tmem16e Transmembrane protein 16E 1.57 NM_029074 Tmem188 Transmembrane protein 188 1.33 NM_027909 Tmem24 Transmembrane protein 24 1.35

63 NM_144534 Tmem38a Transmembrane protein 38A 1.67 NM_028766 Tmem43 Transmembrane protein 43 1.53 NM_019631 Tmem45a Transmembrane protein 45a 1.33 NM_028355 Tmem48 Transmembrane protein 48 1.36 NM_001033271 Tmem55b Transmembrane protein 55b 1.37 NM_144794 Tmem63a Transmembrane protein 63a 1.50 NM_026436 Tmem86a Transmembrane protein 86A 1.46 NM_173734 Tmem87a Transmembrane protein 87A 1.33 NM_133706 Tmem97 Transmembrane protein 97 1.37 NM_080727 Tmprss3 Transmembrane protease, serine 3 1.36 NM_145403 Tmprss4 Transmembrane protease, serine 4 1.41 NM_027902 Tmprss6 Transmembrane serine protease 6 1.44 NM_028651 Tmtc4 Transmembrane and tetratricopeptide repeat containing 4 1.34 NM_009401 Tnfrsf8 Tumor necrosis factor receptor superfamily, member 8 1.39 NM_033622 Tnfsf13b Tumor necrosis factor (ligand) superfamily, member 13b 1.42 NM_183391 Tnfsf18 Tumor necrosis factor (ligand) superfamily, member 18 1.55 NM_009452 Tnfsf4 Tumor necrosis factor (ligand) superfamily, member 4 1.34 NM_172843 Tor1aip2 Torsin A interacting protein 2 1.35 NM_013861 Tpk1 Thiamine pyrophosphokinase 1.55 NM_009417 Tpo Thyroid peroxidase 1.38 NM_009424 Traf6 Tnf receptor-associated factor 6 1.36 NM_028173 Tram1 Translocating chain-associating membrane protein 1 1.72 NM_001024206 Trappc1 Trafficking protein particle complex 1 1.38 NM_001033405 Treml2 Triggering receptor expressed on myeloid cells-like 2 1.50 NM_172623 Treml4 Triggering receptor expressed on myeloid cells-like 4 1.34 NM_023835 Trim12 Tripartite motif protein 12 1.36 NM_001024134 Trim15 Tripartite motif protein 15 1.33 NM_201373 Trim56 Tripartite motif-containing 56 1.54 NM_001013616 Trim6 Tripartite motif protein 6 1.33 NM_153110 Trim61 Tripartite motif-containing 61 1.45 NM_198012 Trim68 Tripartite motif containing 68 1.47 NM_001033429 Trim75 Tripartite motif-containing 75 1.43 NM_013735 Trp53bp1 Transformation related protein 53 binding protein 1 1.32 NM_178111 Trp53inp2 Transformation related protein 53 inducible nuclear protein 2 1.37 NM_138301 Trpm2 Transient receptor potential cation channel, subfamily M, member 2 1.33 NM_177341 Trpm3 Transient receptor potential cation channel, subfamily M, member 3 1.36 NM_001001445 Trpv1 Transient receptor potential cation channel, subfamily V, member 1 1.35 NM_145099 Trpv3 Transient receptor potential cation channel, subfamily V, member 3 1.38 NM_001007572 Trpv5 Transient receptor potential cation channel, subfamily V, member 5 1.33 NM_027925 Trspap1 TRNA selenocysteine associated protein 1 1.34 NM_199033 Tsen2 TRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) 1.38 NM_026743 Tspan11 Tetraspanin 11 1.34 NM_011652 Ttn Titin 1.41 NM_019551 Ttrap Traf and Tnf receptor associated protein 1.34 NM_172253 Twistnb TWIST neighbor 1.34 NM_153519 Txndc2 Thioredoxin domain containing 2 (spermatozoa) 1.54 NM_013711 Txnrd2 Thioredoxin reductase 2 1.36 NM_011662 Tyrobp TYRO protein tyrosine kinase binding protein 1.49 NM_023137 Ubd Ubiquitin D 1.33 NM_030724 Uck2 Uridine-cytidine kinase 2 1.33 NM_031250 Ucn3 Urocortin 3 1.47 NM_053215 Ugt2b37 UDP glucuronosyltransferase 2 family, polypeptide B37 1.38 NM_144873 Uhrf2 Ubiquitin-like, containing PHD and RING finger domains 2 1.39 NM_009469 Ulk1 Unc-51 like kinase 1 (C. elegans) 1.32 NM_009474 Uox Urate oxidase 1.34 NM_133995 Upb1 Ureidopropionase, beta 1.46 NM_023649 Ush1c Usher syndrome 1C homolog (human) 1.33 NM_019490 Uso1 USO1 homolog, vesicle docking protein (yeast) 1.37

64 NM_198421 Usp49 Ubiquitin specific peptidase 49 1.43 NM_181399 Usp6nl USP6 N-terminal like 1.35 NM_011683 V1ra1 Vomeronasal 1 receptor, A1 1.59 NM_011684 V1ra2 Vomeronasal 1 receptor, A2 1.62 NM_053220 V1ra5 Vomeronasal 1 receptor, A5 1.33 NM_053221 V1ra6 Vomeronasal 1 receptor, A6 1.32 NM_053228 V1rb7 Vomeronasal 1 receptor, B7 1.36 NM_053231 V1rc1 Vomeronasal 1 receptor, C1 1.38 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 1.34 NM_134169 V1rc14 Vomeronasal 1 receptor, C14 1.42 NM_134174 V1rc19 Vomeronasal 1 receptor, C19 1.34 NM_134183 V1rc28 Vomeronasal 1 receptor, C28 1.36 NM_134200 V1rf3 Vomeronasal 1 receptor, F3 1.42 NM_134234 V1rg12 Vomeronasal 1 receptor, G12 1.39 NM_134237 V1rh12 Vomeronasal 1 receptor, H12 1.51 NM_134240 V1rh16 Vomeronasal 1 receptor, H16 1.45 NM_134244 V1rh21 Vomeronasal 1 receptor, H21 1.33 NM_134216 V1rh7 Vomeronasal 1 receptor, H7 1.52 NM_009498 Vamp3 Vesicle-associated membrane protein 3 1.40 NM_011690 Vars Valyl-tRNA synthetase 1.35 NM_011693 Vcam1 Vascular cell adhesion molecule 1 1.34 NM_009502 Vcl Vinculin 1.35 NM_173443 Vcpip1 Valosin containing protein (p97)/p47 complex interacting protein 1 1.40 NM_153786 Vgll2 Vestigial like 2 homolog (Drosophila) 1.43 NM_175936 Vmn2r81 Vomeronasal 2, receptor 81 1.34 NM_172120 Vps41 Vacuolar protein sorting 41 (yeast) 1.37 NM_177697 Vwa3a RIKEN cDNA E030013G06 gene 1.42 NM_025362 Wbscr18 Williams-Beuren syndrome chromosome region 18 homolog (human) 1.34 NM_175539 Wdr40c WD repeat domain 40C 1.41 NM_001033240 Wfdc6a WAP four-disulfide core domain 6A 1.42 NM_011717 Wiz Widely-interspaced zinc finger motifs 1.32 NM_053116 Wnt16 Wingless-related MMTV integration site 16 1.42 NM_011723 Xdh Xanthine dehydrogenase 1.39 NM_021365 Xlr4b X-linked lymphocyte-regulated 4B 1.37 NM_183094 Xlr4b X-linked lymphocyte-regulated 4B 1.34 NM_009535 Yes1 Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 1.34 3-monooxygenase/ 5-monooxygenase activation protein, gamma NM_018871 Ywhag polypeptide 1.42 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta NM_011738 Ywhah polypeptide 1.33 NM_174877 Zar1 Zygote arrest 1 1.59 NM_198248 Zbtb40 Zinc finger and BTB domain containing 40 1.46 NM_134003 Zc3h10 Zinc finger CCCH type containing 10 1.51 NM_001008506 Zc3h14 Zinc finger CCCH type containing 14 1.33 NM_028031 Zdhhc13 Zinc finger, DHHC domain containing 13 1.32 NM_175358 Zdhhc15 Zinc finger, DHHC domain containing 15 1.32 NM_020262 Zfp109 Zinc finger protein 109 1.37 NM_153802 Zfp128 Zinc finger protein 128 1.42 NM_001013387 Zfp182 Zinc finger protein 182 1.33 NM_139141 Zfp192 Zinc finger protein 192 1.39 NM_138949 Zfp286 Zinc finger protein 286 1.36 NM_145600 Zfp330 Zinc finger protein 330 1.34 NM_199304 Zfp341 Zinc finger protein 341 1.36 NM_001001186 Zfp456 Zinc finger protein 456 1.34 NM_020589 Zfp467 Zinc finger protein 467 1.35 NM_172617 Zfp523 Zinc finger protein 523 1.32 NM_178707 Zfp592 Zinc finger protein 592 1.38 NM_001024846 Zfp62 Zinc finger protein 62 1.56 NM_001024928 Zfp667 Zinc finger protein 667 1.33

65 NM_145624 Zfp709 Zinc finger protein 709 1.45 NM_001008501 Zfp760 Zinc finger protein 760 1.37 NM_001039532 Zfp784 Zinc finger protein 784 1.49 NM_001007575 Zfp817 Zinc finger protein 817 1.36 NM_001039718 Zfp91 Zinc finger protein 91 1.33 NM_009566 Zfp92 Zinc finger protein 92 1.34 NM_009568 Zfp94 Zinc finger protein 94 1.39 NM_172941 Zkscan17 Zinc finger with KRAB and SCAN domains 17 1.33 NM_177086 Zmat4 Zinc finger, matrin type 4 1.39 NM_144516 Zmynd11 Zinc finger, MYND domain containing 11 1.46 NM_001014900 Zmynd12 Zinc finger, MYND domain containing 12 1.32 NM_026021 Zmynd19 Zinc finger, MYND domain containing 19 1.35 NM_199143 Znrf2 Zinc and ring finger 2 1.37 NM_178720 Zpld1 Zona pellucida like domain containing 1 1.34 NM_011757 Zscan21 Zinc finger and SCAN domain containing 21 1.35 NM_172503 Zswim4 Zinc finger, SWIM domain containing 4 1.37 NM_177080 1.35 NM_001024470 1.37 NM_175510 1.33 NM_175210 1.36 NM_177313 1.38 NM_177131 1.36 NM_008833 1.36 NM_172568 1.35 NM_177008 1.62 NM_172792 1.49 NM_178447 1.32 NM_183110 1.35 NM_001037717 1.36 NM_175218 1.32 NM_134211 1.37 NM_001037921 1.34 NM_001013752 1.45 NM_030054 1.33 NM_153061 1.52 NM_026230 1.35 NM_177819 1.34 NM_029952 1.37 NM_177065 1.46 NM_001013754 1.33 NM_001033154 1.49 NM_177844 1.40 NM_001033806 1.57 NM_010310 1.45 NM_001033814 1.40 NM_001012364 1.44 NM_011473 1.42 NM_178248 1.32 NM_175405 1.62 NM_020295 1.33 NM_177679 1.37 NM_019932 1.36 NM_145575 1.60 NM_001033377 1.35 NM_177737 1.34 NM_130883 1.44 NM_020609 1.33 NM_001033810 1.55

66 NM_001017955 1.37 NM_172408 1.44 NM_001033230 1.42 NM_183108 1.46 NM_177029 1.33 NM_177895 1.52 NM_178902 1.34 NM_001002768 1.47 NM_177589 1.36 NM_008835 1.39 NM_001013819 1.32 NM_001002772 1.33 NM_021898 1.37

SUPPLEMENTAL TABLE S4: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in the Social Isolation Model (p<0.001)

Accession Number Symbol Name Fold Change NM_026714 0610037D15Rik RIKEN cDNA 0610037D15 gene 0.76 NM_173752 1110067D22Rik RIKEN cDNA 1110067D22 gene 0.74 NM_029590 1700010D01Rik RIKEN cDNA 1700010D01 gene 0.78 NM_029326 1700018L24Rik RIKEN cDNA 1700018L24 gene 0.76 NM_026443 1700020C11Rik RIKEN cDNA 1700020C11 gene 0.78 NM_026188 1700028P14Rik RIKEN cDNA 1700028P14 gene 0.77 NM_001033151 1810064F22Rik RIKEN cDNA 1810064F22 gene 0.74 NM_197998 2210021J22Rik RIKEN cDNA 2210021J22 gene 0.73 NM_197999 2210023G05Rik RIKEN cDNA 2210023G05 gene 0.74 NM_027105 2310002B14Rik RIKEN cDNA 2310002B14 gene 0.78 NM_026318 2310003F16Rik RIKEN cDNA 2310003F16 gene 0.78 NM_026655 2310057M21Rik RIKEN cDNA 2310057M21 gene 0.74 NM_025476 2410005O16Rik RIKEN cDNA 2410005O16 gene 0.77 NM_026455 2510049I19Rik RIKEN cDNA 2510049I19 gene 0.76 NM_153780 2610044O15Rik RIKEN cDNA 2610044O15 gene 0.77 NM_026476 2610101N10Rik RIKEN cDNA 2610101N10 gene 0.74 NM_201369 2700092H06Rik RIKEN cDNA 2700092H06 gene 0.77 NM_133749 2900064A13Rik RIKEN cDNA 2900064A13 gene 0.73 NM_025849 3110001D03Rik RIKEN cDNA 3110001D03 gene 0.77 NM_026534 3110003A22Rik RIKEN cDNA 3110003A22 gene 0.77 NM_030093 3300001G02Rik RIKEN cDNA 3300001G02 gene 0.78 NM_172753 4732435N03Rik RIKEN cDNA 4732435N03 gene 0.78 NM_177101 4833442J19Rik RIKEN cDNA 4833442J19 gene 0.76 NM_177195 4930417M19Rik RIKEN cDNA 4930417M19 gene 0.73 NM_029144 4930503B20Rik RIKEN cDNA 4930503B20 gene 0.78 NM_207204 4930519N13Rik RIKEN cDNA 4930519N13 gene 0.77 NM_027631 4931407G18Rik RIKEN cDNA 4931407G18 gene 0.74 NM_025737 4931417E11Rik RIKEN cDNA 4931417E11 gene 0.78 NM_001037718 4932415M13Rik RIKEN cDNA 4932415M13 gene 0.78 NM_175165 5430420C16Rik RIKEN cDNA 5430420C16 gene 0.77 NM_178658 6330500D04Rik RIKEN cDNA 6330500D04 gene 0.77 NM_177656 6820408C15Rik RIKEN cDNA 6820408C15 gene 0.76 NM_028984 8430406I07Rik RIKEN cDNA 8430406I07 gene 0.76 NM_198636 8430416H19Rik RIKEN cDNA 8430416H19 gene 0.74 NM_027829 9030607L17Rik RIKEN cDNA 9030607L17 gene 0.65 NM_177175 A930001M12Rik RIKEN cDNA A930001M12 gene 0.78 NM_023383 Aadac Arylacetamide deacetylase (esterase) 0.77 NM_172961 Abat 4-aminobutyrate aminotransferase 0.63 NM_001039581 Abca3 ATP-binding cassette, sub-family A (ABC1), member 3 0.74 NM_007378 Abca4 ATP-binding cassette, sub-family A (ABC1), member 4 0.71

67 NM_008992 Abcd4 ATP-binding cassette, sub-family D (ALD), member 4 0.77 NM_007382 Acadm Acyl-Coenzyme A dehydrogenase, medium chain 0.76 NM_025826 Acadsb Acyl-Coenzyme A dehydrogenase, short/branched chain 0.77 NM_134037 Acly ATP citrate lyase 0.76 NM_007391 Acrv1 Acrosomal vesicle protein 1 0.76 NM_020330 Adam21 A disintegrin and metallopeptidase domain 21 0.73 NM_153397 Adam32 A disintegrin and metallopeptidase domain 32 0.76 NM_023538 Agk Acylglycerol kinase 0.78 NM_178899 AI987662 Expressed sequence AI987662 0.77 NM_009648 Akap1 A kinase (PRKA) anchor protein 1 0.71 NM_194462 Akap9 A kinase (PRKA) anchor protein (yotiao) 9 0.77 NM_009658 Akr1b3 Aldo-keto reductase family 1, member B3 (aldose reductase) 0.74 NM_172532 Aldh5a1 Aldhehyde dehydrogenase family 5, subfamily A1 0.75 -linked glycosylation 11 homolog (yeast, alpha-1,2- NM_183142 Alg11 mannosyltransferase) 0.78 NM_026303 Alkbh8 AlkB, alkylation repair homolog 8 (E. coli) 0.77 NM_009666 Amelx Amelogenin 0.77 NM_153319 Amot Angiomotin 0.75 NM_001013806 Ankrd13c Ankyrin repeat domain 13c 0.77 NM_007457 Ap1s1 Adaptor protein complex AP-1, sigma 1 0.76 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 0.77 NM_019735 Apip APAF1 interacting protein 0.75 NM_145996 Arid5a AT rich interactive domain 5A (Mrf1 like) 0.77 NM_028840 Armc1 Armadillo repeat containing 1 0.73 NM_025549 Arrdc4 domain containing 4 0.76 NM_026853 Asb11 Ankyrin repeat and SOCS box-containing protein 11 0.77 NM_020051 Ascl3 Achaete-scute complex homolog-like 3 (Drosophila) 0.70 NM_007507 Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e 0.77 NM_001033215 AU017455 Expressed sequence AU017455 0.78 NM_177682 AU022870 Expressed sequence AU022870 0.78 NM_001033532 AW554918 Expressed sequence AW554918 0.77 NM_199313 AY053573 CDNA sequence AY053573 0.77 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene 0.68 Xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 NM_146045 B4galt7 (galactosyltransferase I) 0.76 NM_019517 Bace2 Beta-site APP-cleaving enzyme 2 0.76 NM_027395 Basp1 Brain abundant, membrane attached signal protein 1 0.78 NM_175325 Bbs4 Bardet-Biedl syndrome 4 homolog (human) 0.77 NM_145490 BC011426 CDNA sequence BC011426 0.76 NM_001033328 BC023829 CDNA sequence BC023829 0.77 NM_001003939 BC030307 CDNA sequence BC030307 0.78 NM_177878 BC038925 CDNA sequence BC038925 0.73 NM_181419 BC050092 CDNA sequence BC050092 0.76 NM_001004180 BC057022 CDNA sequence BC057022 0.74 NM_198631 BC057627 CDNA sequence BC057627 0.76 NM_026602 Bcas2 Breast carcinoma amplified sequence 2 0.74 NM_198161 Bhlhb9 Basic helix-loop-helix domain containing, class B9 0.67 NM_144558 Bivm Basic, immunoglobulin-like variable motif containing 0.76 NM_007550 Blm Bloom syndrome homolog (human) 0.78 NM_009755 Bmp1 Bone morphogenetic protein 1 0.78 NM_198095 Bst2 Bone marrow stromal cell antigen 2 0.76 NM_001037719 Btla B and T lymphocyte associated 0.74 NM_020558 C1d Nuclear DNA binding protein 0.78 NM_027687 Cabyr Calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2) 0.77 NM_019430 Cacng3 , voltage-dependent, gamma subunit 3 0.76 NM_007586 Calb2 2 0.71 NM_026192 Calcoco1 Calcium binding and coiled coil domain 1 0.76 NM_007588 Calcr Calcitonin receptor 0.74 NM_020036 Calm4 Calmodulin 4 0.78

68 NM_007599 Capg Capping protein (actin filament), -like 0.73 NM_016900 Cav2 Caveolin 2 0.72 NM_144822 Cbara1 Calcium binding atopy-related autoantigen 1 0.75 NM_134048 Cbll1 Casitas B-lineage lymphoma-like 1 0.76 NM_001033261 Ccdc131 Coiled-coil domain containing 131 0.75 NM_146089 Ccdc5 Coiled-coil domain containing 5 0.75 NM_201362 Ccdc68 Coiled-coil domain containing 68 0.76 NM_026439 Ccdc80 Coiled-coil domain containing 80 0.77 NM_013654 Ccl7 Chemokine (C-C motif) ligand 7 0.74 NM_011338 Ccl9 Chemokine (C-C motif) ligand 9 0.73 NM_019937 Ccnl1 Cyclin 0.73 NM_172050 Cd300e CD300e antigen 0.78 NM_025950 Cdc37l1 Cell division cycle 37 homolog (S. cerevisiae)-like 1 0.75 NM_007674 Cdx4 Caudal type homeo box 4 0.77 NM_145126 Chi3l4 Chitinase 3-like 4 0.72 NM_007697 Chl1 Cell adhesion molecule with homology to L1CAM 0.70 NM_175752 Chn1 (chimaerin) 1 0.73 NM_173385 Cilp Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.72 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal NM_019563 Cited4 domain, 4 0.76 NM_025415 Cks2 CDC28 protein kinase regulatory subunit 2 0.57 NM_022890 Cldn12 Claudin 12 0.58 NM_019649 Clptm1 Cleft lip and palate associated transmembrane protein 1 0.65 NM_053096 Cml2 Camello-like 2 0.77 NM_007734 Col4a3 Procollagen, type IV, alpha 3 0.76 NM_007740 Col9a1 Procollagen, type IX, alpha 1 0.75 NM_015827 Copb2 Coatomer protein complex, subunit beta 2 (beta prime) 0.68 NM_009898 Coro1a Coronin, actin binding protein 1A 0.78 NM_030205 Coro7 Coronin 7 0.73 NM_009941 Cox4i1 Cytochrome c oxidase subunit IV isoform 1 0.77 NM_009945 Cox7a2 Cytochrome c oxidase, subunit VIIa 2 0.78 NM_007764 Crkl V-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.70 NM_001024385 Crls1 Cardiolipin synthase 1 0.74 NM_026906 Cts3 Cathepsin 3 0.76 NM_009983 Ctsd Cathepsin D 0.76 NM_008411 Cuzd1 CUB and zona pellucida-like domains 1 0.76 NM_008599 Cxcl9 Chemokine (C-X-C motif) ligand 9 0.78 NM_025558 Cyb5b Cytochrome b5 type B 0.72 NM_201351 Cybasc3 Cytochrome b, ascorbate dependent 3 0.78 NM_007815 Cyp2c29 Cytochrome P450, family 2, subfamily c, polypeptide 29 0.71 NM_010001 Cyp2c37 Cytochrome P450, family 2. subfamily c, polypeptide 37 0.75 NM_013809 Cyp2g1 Cytochrome P450, family 2, subfamily g, polypeptide 1 0.78 NM_025738 Cypt6 Cysteine-rich perinuclear theca 6 0.72 NM_172669 D030051N19Rik RIKEN cDNA D030051N19 gene 0.75 NM_175275 D530005L17Rik RIKEN cDNA D530005L17 gene 0.77 NM_022994 Dap3 Death associated protein 3 0.78 NM_028523 Dcbld2 Discoidin, CUB and LCCL domain containing 2 0.77 NM_016890 Dctn3 Dynactin 3 0.77 NM_172284 Ddx19b DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b 0.76 NM_139222 Defb15 Defensin beta 15 0.78 NM_199067 Defb50 Defensin beta 50 0.68 NM_144804 Depdc7 DEP domain containing 7 0.71 NM_029585 Det1 De-etiolated homolog 1 (Arabidopsis) 0.76 NM_026144 Dhdds Dehydrodolichyl diphosphate synthase 0.71 NM_026191 Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.78 NM_017398 Diap2 Diaphanous homolog 2 (Drosophila) 0.78 NM_024181 Dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.74 NM_172704 Dnajc11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.77 NM_172624 Dpp9 Dipeptidylpeptidase 9 0.77

69 NM_026106 Dr1 Down-regulator of transcription 1 0.71 NM_007887 Dub1 Deubiquitinating enzyme 1 0.73 NM_028002 Dus4l Dihydrouridine synthase 4-like (S. cerevisiae) 0.75 NM_010064 Dync1i2 Dynein cytoplasmic 1 intermediate chain 2 0.77 NM_021469 Dysf 0.78 NM_025943 Dzip1 DAZ interacting protein 1 0.71 NM_183160 E030010A14Rik RIKEN cDNA E030010A14 gene 0.76 NM_029166 E030041M21Rik RIKEN cDNA E030041M21 gene 0.72 NM_178791 E130203B14Rik RIKEN cDNA E130203B14 gene 0.77 NM_033270 E2f6 E2F transcription factor 6 0.75 NM_053113 Ear11 Eosinophil-associated, ribonuclease A family, member 11 0.77 NM_010095 Ebf2 Early B-cell factor 2 0.76 NM_146015 Efemp1 Epidermal growth factor-containing -like extracellular matrix protein 1 0.76 NM_010110 Efnb1 Ephrin B1 0.77 NM_177593 EG210155 Predicted gene, EG210155 0.78 NM_177764 EG269902 Predicted gene, EG269902 0.65 NM_001025240 EG384813 Predicted gene, EG384813 0.75 NM_001034882 EG432879 Predicted gene, EG432879 0.72 NM_001034102 EG545047 Predicted gene, EG545047 0.72 NM_001039119 EG654453 Predicted gene, EG654453 0.70 NM_178444 Egfl7 EGF-like domain 7 0.74 NM_008388 Eif3e Eukaryotic translation initiation factor 3, subunit E 0.73 NM_001039175 Elovl1 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 0.78 NM_016885 Emcn Endomucin 0.63 NM_134005 Enpp3 Ectonucleotide pyrophosphatase/phosphodiesterase 3 0.75 NM_172117 Entpd6 Ectonucleoside triphosphate diphosphohydrolase 6 0.73 Excision repair cross-complementing rodent repair deficiency, complementation NM_015769 Ercc4 group 4 0.77 NM_007956 Esr1 1 (alpha) 0.78 NM_026576 Etaa1 Ewing's tumor-associated antigen 1 0.77 NM_025513 Exosc3 Exosome component 3 0.77 NM_176846 Exph5 Exophilin 5 0.75 NM_010165 Eya2 Eyes absent 2 homolog (Drosophila) 0.78 NM_007978 F8a Factor 8-associated gene A 0.78 NM_010176 Fah Fumarylacetoacetate hydrolase 0.76 NM_025850 Fank1 Fibronectin type 3 and ankyrin repeat domains 1 0.73 NM_010191 Fdft1 Farnesyl diphosphate farnesyl transferase 1 0.76 NM_134469 Fdps Farnesyl diphosphate synthetase 0.69 NM_008000 Fert2 Fer (fms/fps related) protein kinase, testis specific 2 0.76 NM_008001 Fgd1 FYVE, RhoGEF and PH domain containing 1 0.74 NM_016863 Fkbp1b FK506 binding protein 1b 0.78 NM_001013804 Flg2 family member 2 0.78 NM_201518 Flrt2 Fibronectin leucine rich transmembrane protein 2 0.75 NM_178382 Flrt3 Fibronectin leucine rich transmembrane protein 3 0.76 NM_018828 Fnbp4 Formin binding protein 4 0.78 NM_177091 Fndc7 Fibronectin type III domain containing 7 0.71 NM_016893 Fut8 8 0.77 NM_052823 Fxyd2 FXYD domain-containing ion transport regulator 2 0.71 NM_001033433 G630025P09Rik RIKEN cDNA G630025P09 gene 0.78 NM_020590 Gabarapl1 Gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1 0.74 NM_008072 Gabrd Gamma-aminobutyric acid (GABA-A) receptor, subunit delta 0.78 NM_177408 Gabrg2 Gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2 0.77 NM_001039560 Gcnt7 Glucosaminyl (N-acetyl) transferase family member 7 0.75 NM_177696 Gdpd4 Glycerophosphodiester phosphodiesterase domain containing 4 0.77 NM_138591 Gfm1 G elongation factor, mitochondrial 1 0.77 NM_205844 Gfral GDNF family receptor alpha like 0.64 NM_145929 Gga1 Golgi associated, gamma adaptin ear containing, ARF binding protein 1 0.76 NM_008120 Gja4 Gap junction membrane channel protein alpha 4 0.77 NM_178596 Gjc1 Gap junction membrane channel protein chi 1 0.68

70 NM_025466 Gkn1 Gastrokine 1 0.77 NM_033320 Glce Glucuronyl C5-epimerase 0.74 NM_020492 Glra1 , alpha 1 subunit 0.76 NM_080438 Glra3 Glycine receptor, alpha 3 subunit 0.70 NM_022024 Gmfg Glia maturation factor, gamma 0.73 NM_001033300 Gmps Guanine monphosphate synthetase 0.77 NM_020585 Golga7 Golgi autoantigen, golgin subfamily a, 7 0.78 NM_010325 Got2 Glutamate oxaloacetate transaminase 2, mitochondrial 0.77 NM_026367 Gpatch2 G patch domain containing 2 0.61 NM_008161 Gpx3 Glutathione peroxidase 3 0.70 NM_015764 Greb1 Gene regulated by estrogen in breast cancer protein 0.78 NM_008177 Grpr Gastrin releasing peptide receptor 0.77 NM_029727 Gsdm2 Gasdermin 2 0.74 NM_008179 Gspt2 G1 to S phase transition 2 0.75 NM_010356 Gsta3 Glutathione S-transferase, alpha 3 0.78 NM_010375 Gzmg Granzyme G 0.74 NM_177634 H2-M10.4 Histocompatibility 2, M region locus 10.4 0.77 NM_010398 H2-T23 Histocompatibility 2, T region locus 23 0.78 NM_011826 Hax1 HCLS1 associated X-1 0.75 NM_010417 Heph Hephaestin 0.70 NM_175665 Hist1h2bk Histone cluster 1, H2bk 0.78 NM_175654 Hist1h4d Histone cluster 1, H4d 0.72 NM_175657 Hist1h4m Histone cluster 1, H4m 0.78 NM_019469 Hist2h3b Histone cluster 2, H3b 0.77 NM_009330 Hnf1b HNF1 homeobox B 0.54 NM_144802 Hnrpll Heterogeneous nuclear ribonucleoprotein L-like 0.74 NM_028742 Ifltd1 Intermediate filament tail domain containing 1 0.76 NM_009879 Ift81 81 homolog (Chlamydomonas) 0.75 NM_153511 Il1f9 Interleukin 1 family, member 9 0.75 NM_008364 Il1rap Interleukin 1 receptor accessory protein 0.76 NM_021380 Il20 0.73 NM_009909 Il8rb Interleukin 8 receptor, beta 0.77 NM_023503 Ing2 Inhibitor of growth family, member 2 0.78 NM_008385 Inpp5b Inositol polyphosphate-5-phosphatase B 0.77 NM_010566 Inpp5d Inositol polyphosphate-5-phosphatase D 0.74 NM_008386 Ins1 Insulin I 0.77 NM_010578 Itgb1 (fibronectin receptor beta) 0.71 NM_013566 Itgb7 0.77 NM_011365 Itsn2 Intersectin 2 0.77 NM_023844 Jam2 Junction adhesion molecule 2 0.77 NM_010601 Kcnh3 Potassium voltage-gated channel, subfamily H (eag-related), member 3 0.76 NM_183179 Kcnv2 Potassium channel, subfamily V, member 2 0.75 NM_010640 Klk1b11 Kallikrein 1-related peptidase b11 0.75 NM_020268 Klk1b27 Kallikrein 1-related peptidase b27 0.78 NM_008463 Klra5 Killer cell lectin-like receptor, subfamily A, member 5 0.69 NM_133922 Krba1 KRAB-A domain containing 1 0.70 NM_015809 Krtap5-4 Keratin associated protein 5-4 0.76 NM_029571 Kti12 KTI12 homolog, chromatin associated (S. cerevisiae) 0.73 NM_145743 Lace1 Lactation elevated 1 0.78 NM_033521 Laptm4b Lysosomal-associated protein transmembrane 4B 0.78 NM_008509 Lpl 0.77 NM_028915 Lrrcc1 Leucine rich repeat and coiled-coil domain containing 1 0.77 NM_175641 Ltbp4 Latent transforming growth factor beta binding protein 4 0.76 NM_028190 Luc7l Luc7 homolog (S. cerevisiae)-like 0.77 NM_011837 Ly6h Lymphocyte antigen 6 complex, locus H 0.69 NM_053247 Lyve1 Lymphatic vessel endothelial hyaluronan receptor 1 0.76 NM_013590 Lyz Lysozyme 0.78 NM_033322 Lztfl1 Leucine zipper transcription factor-like 1 0.74

71 NM_025836 M6prbp1 Mannose-6-phosphate receptor binding protein 1 0.75 NM_025649 Mad2l1bp MAD2L1 binding protein 0.76 NM_020280 Magea4 Melanoma antigen, family A, 4 0.75 NM_178920 Mal2 Mal, T-cell differentiation protein 2 0.78 NM_025729 Map3k7ip3 Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 0.77 NM_019709 Mbtps1 Membrane-bound transcription factor peptidase, site 1 0.76 NM_030174 Mctp1 Multiple C2 domains, transmembrane 1 0.78 NM_175088 Mdfic MyoD family inhibitor domain containing 0.78 NM_181407 Me3 Malic enzyme 3, NADP(+)-dependent, mitochondrial 0.75 NM_008578 Mef2b Myocyte enhancer factor 2B 0.78 NM_027756 Mfap3l Microfibrillar-associated protein 3-like 0.78 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, NM_026243 Mgat4c isozyme C (putative) 0.75 NM_013791 Mkln1 Muskelin 1, intracellular mediator containing kelch motifs 0.78 NM_177595 Mkx Mohawk 0.76 NM_145385 Mlf2 Myeloid leukemia factor 2 0.77 NM_026178 Mmd Monocyte to macrophage differentiation-associated 0.67 NM_080453 Mmp28 Matrix metallopeptidase 28 (epilysin) 0.72 NM_010809 Mmp3 Matrix metallopeptidase 3 0.73 NM_176993 Mpzl3 -like 3 0.77 NM_205810 Mrgprb1 MAS-related GPR, member B1 0.73 NM_013516 Ms4a2 Membrane-spanning 4-domains, subfamily A, member 2 0.78 NM_026322 Msra Methionine sulfoxide reductase A 0.77 NM_023858 Mtmr2 Myotubularin related protein 2 0.77 NM_008642 Mttp Microsomal triglyceride transfer protein 0.77 NM_172979 Muc15 Mucin 15 0.77 NM_175541 Mum1l1 Melanoma associated antigen (mutated) 1-like 1 0.74 NM_001039544 Mup3 Major urinary protein 3 0.78 NM_008652 Mybl2 Myeloblastosis oncogene-like 2 0.73 NM_010852 Myef2 expression factor 2, 0.77 NM_021285 Myl1 Myosin, light polypeptide 1 0.78 NM_010863 Myo1b Myosin IB 0.77 NM_008659 Myo1c Myosin IC 0.77 NM_001009546 Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.78 NM_019750 Nat6 N-acetyltransferase 6 0.77 NM_019744 Ncoa4 Nuclear receptor coactivator 4 0.75 NM_008681 Ndrg1 N-myc downstream regulated gene 1 0.77 NM_031186 Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 0.72 NM_025987 Ndufa6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14) 0.78 NM_019435 Ndufb11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 0.78 NM_025316 Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 0.63 NM_145138 Nek9 NIMA (never in mitosis gene a)-related expressed kinase 9 0.75 NM_029891 Nkrf NF-kappaB repressing factor 0.78 NM_001039234 Nlrp1c NLR family, pyrin domain containing 1C 0.76 NM_008704 Nme1 Expressed in non-metastatic cells 1, protein 0.76 NM_178071 Nme7 Non-metastatic cells 7, protein expressed in 0.66 NM_145857 Nod2 Nucleotide-binding oligomerization domain containing 2 0.77 NM_010928 Notch2 Notch gene homolog 2 (Drosophila) 0.75 NM_176930 Nrcam Neuron-glia-CAM-related cell adhesion molecule 0.75 NM_013745 Nufip1 Nuclear fragile X mental retardation protein interacting protein 1 0.76 NM_027191 Nup37 Nucleoporin 37 0.78 NM_130858 Nxph3 Neurexophilin 3 0.73 NM_001003914 Obscn , cytoskeletal calmodulin and titin-interacting RhoGEF 0.77 NM_025942 Ola1 Obg-like ATPase 1 0.76 NM_153458 Olfm3 Olfactomedin 3 0.76 NM_206822 Olfr10 Olfactory receptor 10 0.76 NM_146580 Olfr1020 Olfactory receptor 1020 0.72 NM_146588 Olfr1030 Olfactory receptor 1030 0.78 NM_146577 Olfr1043 Olfactory receptor 1043 0.77

72 NM_001011735 Olfr1066 Olfactory receptor 1066 0.73 NM_146846 Olfr1087 Olfactory receptor 1087 0.75 NM_147030 Olfr1134 Olfactory receptor 1134 0.74 NM_001011833 Olfr1137 Olfactory receptor 1137 0.76 NM_146638 Olfr1151 Olfactory receptor 1151 0.78 NM_146647 Olfr1154 Olfactory receptor 1154 0.77 NM_146849 Olfr1157 Olfactory receptor 1157 0.74 NM_001011835 Olfr1162 Olfactory receptor 1162 0.77 NM_146919 Olfr1188 Olfactory receptor 1188 0.75 NM_146459 Olfr1215 Olfactory receptor 1215 0.69 NM_146966 Olfr1247 Olfactory receptor 1247 0.74 NM_146965 Olfr1250 Olfactory receptor 1250 0.77 NM_146476 Olfr1254 Olfactory receptor 1254 0.62 NM_146393 Olfr1279 Olfactory receptor 1279 0.77 NM_146404 Olfr1289 Olfactory receptor 1289 0.76 NM_146888 Olfr1297 Olfactory receptor 1297 0.77 NM_207240 Olfr1320 Olfactory receptor 1320 0.74 NM_207631 Olfr1321 Olfactory receptor 1321 0.78 NM_207573 Olfr1380 Olfactory receptor 1380 0.74 NM_146468 Olfr1391 Olfactory receptor 1391 0.77 NM_146471 Olfr1393 Olfactory receptor 1393 0.75 NM_146763 Olfr1406 Olfactory receptor 1406 0.74 NM_146414 Olfr1431 Olfactory receptor 1431 0.74 NM_146431 Olfr1510 Olfactory receptor 1510 0.76 NM_146935 Olfr167 Olfactory receptor 167 0.76 NM_146484 Olfr197 Olfactory receptor 197 0.76 NM_146429 Olfr223 Olfactory receptor 223 0.74 NM_146405 Olfr228 Olfactory receptor 228 0.77 NM_146920 Olfr267 Olfactory receptor 267 0.76 NM_001011752 Olfr293 Olfactory receptor 293 0.71 NM_146878 Olfr30 Olfactory receptor 30 0.75 NM_001011743 Olfr324 Olfactory receptor 324 0.73 NM_207235 Olfr358 Olfactory receptor 358 0.74 NM_146707 Olfr410 Olfactory receptor 410 0.78 NM_146711 Olfr43 Olfactory receptor 43 0.78 NM_146718 Olfr430 Olfactory receptor 430 0.77 NM_146654 Olfr438 Olfactory receptor 438 0.74 NM_146295 Olfr446 Olfactory receptor 446 0.73 NM_146383 Olfr460 Olfactory receptor 460 0.77 NM_146372 Olfr509 Olfactory receptor 509 0.78 NM_146960 Olfr53 Olfactory receptor 53 0.69 NM_147119 Olfr632 Olfactory receptor 632 0.77 NM_147120 Olfr638 Olfactory receptor 638 0.77 NM_147060 Olfr667 Olfactory receptor 667 0.76 NM_001011749 Olfr704 Olfactory receptor 704 0.73 NM_146780 Olfr715 Olfactory receptor 715 0.70 NM_054090 Olfr73 Olfactory receptor 73 0.73 NM_146668 Olfr739 Olfactory receptor 739 0.73 NM_146931 Olfr796 Olfactory receptor 796 0.74 NM_146674 Olfr824 Olfactory receptor 824 0.75 NM_146676 Olfr826 Olfactory receptor 826 0.76 NM_146566 Olfr830 Olfactory receptor 830 0.77 NM_146567 Olfr843 Olfactory receptor 843 0.78 NM_146802 Olfr902 Olfactory receptor 902 0.77 NM_146784 Olfr916 Olfactory receptor 916 0.73 NM_001011518 Olfr94 Olfactory receptor 94 0.75 NM_146506 Olfr945 Olfactory receptor 945 0.71 NM_207141 Olfr955 Olfactory receptor 955 0.77

73 NM_146504 Olfr961 Olfactory receptor 961 0.74 NM_146612 Olfr968 Olfactory receptor 968 0.78 NM_201258 Oog3 Oogenesin 3 0.69 NM_133752 Opa1 Optic atrophy 1 homolog (human) 0.72 NM_177614 Os9 Amplified in osteosarcoma 0.78 NM_027881 Osbpl3 Oxysterol binding protein-like 3 0.74 NM_001009550 OTTMUSG00000000231 Predicted gene, OTTMUSG00000000231 0.75 NM_001013393 OTTMUSG00000001246 Predicted gene, OTTMUSG00000001246 0.76 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.73 NM_145460 Oxnad1 Oxidoreductase NAD-binding domain containing 1 0.78 NM_146169 Paip2b Poly(A) binding protein interacting protein 2B 0.77 NM_008780 Pax1 Paired box gene 1 0.74 NM_026701 Pbld Phenazine biosynthesis-like protein domain containing 0.78 NM_138661 Pcdha11 Protocadherin alpha 11 0.78 NM_053128 Pcdhb3 Protocadherin beta 3 0.76 NM_033588 Pcdhga12 Protocadherin gamma subfamily A, 12 0.76 NM_033576 Pcdhga12 Protocadherin gamma subfamily A, 12 0.67 NM_033579 Pcdhga12 Protocadherin gamma subfamily A, 12 0.60 NM_013628 Pcsk1 Proprotein convertase subtilisin/kexin type 1 0.77 NM_016744 Pde1a Phosphodiesterase 1A, calmodulin-dependent 0.77 NM_033614 Pde6c Phosphodiesterase 6C, cGMP specific, cone, alpha prime 0.78 NM_172263 Pde8b Phosphodiesterase 8B 0.72 NM_008811 Pdha2 Pyruvate dehydrogenase E1 alpha 2 0.76 NM_172665 Pdk1 Pyruvate dehydrogenase kinase, isoenzyme 1 0.76 NM_027772 Pdss2 Prenyl (solanesyl) diphosphate synthase, subunit 2 0.75 NM_018858 Pebp1 Phosphatidylethanolamine binding protein 1 0.78 NM_011868 Peci Peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase 0.75 NM_028132 Pgm2 Phosphoglucomutase 2 0.76 NM_172453 Pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 0.75 NM_008841 Pik3r2 Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) 0.76 NM_026163 Pkp2 Plakophilin 2 0.76 NM_008873 Plau Plasminogen activator, 0.75 NM_008883 Plxna3 Plexin A3 0.77 NM_025928 Pmf1 Polyamine-modulated factor 1 0.51 NM_027196 Pold4 Polymerase (DNA-directed), delta 4 0.78 NM_026389 Poldip2 Polymerase (DNA-directed), delta interacting protein 2 0.76 NM_029977 Polq Polymerase (DNA directed), theta 0.71 NM_029763 Polr3f Polymerase (RNA) III (DNA directed) polypeptide F 0.77 NM_008895 Pomc1 Pro-opiomelanocortin-alpha 0.76 NM_198933 Pou2f1 POU domain, class 2, transcription factor 1 0.73 NM_008247 Ppap2a Phosphatidic acid phosphatase 2a 0.78 NM_153089 Ppp1r16b Protein phosphatase 1, regulatory (inhibitor) subunit 16B 0.75 NM_017374 Ppp2cb Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 0.64 NM_198669 Prb1 Proline-rich protein BstNI subfamily 1 0.78 NM_011164 Prl Prolactin 0.78 NM_019991 Prl2a1 Prolactin family 2, subfamily a, member 1 0.76 NM_025532 Prl2b1 Prolactin family 2, subfamily b, member 1 0.76 NM_022415 Ptges 0.71 Protein tyrosine phosphatase-like (proline instead of catalytic arginine), member NM_001012396 Ptpla a 0.76 NM_011220 Pts 6-pyruvoyl-tetrahydropterin synthase 0.76 NM_023292 Pus3 Pseudouridine synthase 3 0.78 NM_011223 Pxn 0.78 NM_021888 Qtrt1 Queuine tRNA-ribosyltransferase 1 0.76 NM_011227 Rab20 RAB20, member RAS oncogene family 0.71 NM_018750 Rassf5 Ras association (RalGDS/AF-6) domain family 5 0.78 NM_009826 Rb1cc1 RB1-inducible coiled-coil 1 0.77 NM_001038846 Rcsd1 RCSD domain containing 1 0.72 NM_173402 Rgs12 Regulator of G-protein signaling 12 0.77

74 NM_153171 Rgs13 Regulator of G-protein signaling 13 0.78 NM_011267 Rgs16 Regulator of G-protein signaling 16 0.75 NM_201236 Rhox4e Reproductive homeobox 4E 0.76 NM_001039698 Rhox4h Reproductive homeobox 4H 0.78 NM_028904 Rmi1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) 0.77 NM_001011877 Rnase11 Ribonuclease, RNase A family, 11 (non-active) 0.76 NM_028810 Rho family GTPase 3 0.73 NM_016698 Rnf10 Ring finger protein 10 0.77 NM_033604 Rnf111 Ring finger 111 0.76 NM_001033135 Rnf149 Ring finger protein 149 0.66 NM_011281 Rorc RAR-related orphan receptor gamma 0.78 NM_001037916 RP23-233B9.8 Hypothetical protein LOC622665 0.76 NM_183280 RP23-438H3.2 Hypothetical protein LOC69357 0.77 NM_009083 Rpl30 Ribosomal protein L30 0.76 NM_001004154 Rragb Ras-related GTP binding B 0.77 NM_010925 Rrp1 Ribosomal RNA processing 1 homolog (S. cerevisiae) 0.77 NM_027100 Rwdd2a RWD domain containing 2A 0.76 NM_023868 Ryr2 , cardiac 0.72 NM_178883 Scyl1bp1 SCY1-like 1 binding protein 1 0.74 NM_028776 Scyl3 SCY1-like 3 (S. cerevisiae) 0.68 NM_027135 Sec24d SEC24 related gene family, member D (S. cerevisiae) 0.78 NM_146003 Senp6 SUMO/sentrin specific peptidase 6 0.67 NM_025429 Serpinb1a Serine (or cysteine) peptidase inhibitor, clade B, member 1a 0.78 NM_011454 Serpinb6b Serine (or cysteine) peptidase inhibitor, clade B, member 6b 0.75 NM_009776 Serping1 Serine (or cysteine) peptidase inhibitor, clade G, member 1 0.77 NM_001013370 Sesn1 Sestrin 1 0.78 NM_013834 Sfrp1 Secreted frizzled-related protein 1 0.68 NM_172592 Sfrs12 Splicing factor, arginine/serine-rich 12 0.73 NM_009163 Sgpl1 Sphingosine phosphate lyase 1 0.78 NM_001033499 Sh2d1b2 SH2 domain protein 1B2 0.77 NM_172937 Shprh SNF2 histone linker PHD RING helicase 0.76 NM_001002898 Sirpb1 Signal-regulatory protein beta 1 0.76 NM_008766 Slc22a6 Solute carrier family 22 (organic anion transporter), member 6 0.74 NM_031194 Slc22a8 Solute carrier family 22 (organic anion transporter), member 8 0.75 NM_175034 Slc24a5 Solute carrier family 24, member 5 0.69 NM_007885 Slc26a2 Solute carrier family 26 (sulfate transporter), member 2 0.73 NM_172980 Slc28a2 Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 0.70 NM_009579 Slc30a1 Solute carrier family 30 (zinc transporter), member 1 0.75 NM_175090 Slc31a1 Solute carrier family 31, member 1 0.74 NM_139143 Slc39a6 Solute carrier family 39 (metal ), member 6 0.66 NM_007515 Slc7a3 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.71 NM_016972 Slc7a8 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 0.78 NM_181545 Slfn8 Schlafen 8 0.67 Swi/SNF related matrix associated, actin dependent regulator of chromatin, NM_018817 Smarcal1 subfamily a-like 1 0.78 NM_028887 Smchd1 SMC hinge domain containing 1 0.76 NM_009214 Sms Spermine synthase 0.78 NM_033568 Snf8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.75 NM_178252 Snx26 Sorting nexin 26 0.74 NM_138657 Socs7 Suppressor of cytokine signaling 7 0.75 NM_029160 Spag16 Sperm associated antigen 16 0.74 NM_025668 Spcs2 Signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.78 NM_001029936 Specc1 Sperm antigen with calponin homology and coiled-coil domains 1 0.76 NM_153406 Specc1l SPECC1-like 0.77 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 0.76 NM_030061 Spink12 Serine peptidase inhibitor, Kazal type 11 0.74 NM_009263 Spp1 Secreted phosphoprotein 1 0.73 NM_011469 Sprr2b Small proline-rich protein 2B 0.77 NM_198898 Ssxb10 Synovial sarcoma, X member B, breakpoint 10 0.77

75 NM_199066 Ssxb2 Synovial sarcoma, X member B, breakpoint 2 0.78 NM_009177 St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.71 NM_009182 St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.70 NM_173869 Stfa2l1 Stefin A2 like 1 0.63 NM_009185 Stil Scl/Tal1 interrupting locus 0.74 NM_011500 Strn Striatin, calmodulin binding protein 0.77 NM_009295 Stxbp1 Syntaxin binding protein 1 0.77 NM_011507 Suclg2 Succinate-Coenzyme A ligase, GDP-forming, beta subunit 0.72 NM_009301 Svs5 Seminal vesicle secretory protein 5 0.77 NM_181529 Syt15 Synaptotagmin XV 0.78 NM_001040086 Sytl2 Synaptotagmin-like 2 0.73 NM_001010839 Taar7f Trace amine-associated receptor 7F 0.78 NM_027427 Taf15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.77 NM_011528 Taldo1 Transaldolase 1 0.68 NM_001003898 Tardbp TAR DNA binding protein 0.78 NM_207026 Tas2r124 Taste receptor, type 2, member 124 0.77 NM_030732 Tbl1xr1 (beta)-like 1X-linked receptor 1 0.75 NM_013763 Tbl2 Transducin (beta)-like 2 0.78 NM_032005 Tbx19 T-box 19 0.76 NM_177919 Tceal5 Transcription elongation factor A (SII)-like 5 0.71 NM_026305 Tceb2 Transcription elongation factor B (SIII), polypeptide 2 0.76 NM_013775 Tcl1b2 T-cell leukemia/lymphoma 1B, 2 0.74 NM_009341 Tcp10c T-complex protein 10c 0.78 NM_021480 Tdh L-threonine dehydrogenase 0.71 NM_178244 Teddm1 Transmembrane epididymal protein 1 0.74 NM_019643 Tera Teratocarcinoma expressed, serine rich 0.76 NM_009359 Tex9 Testis expressed gene 9 0.76 NM_011575 Tff3 Trefoil factor 3, intestinal 0.55 NM_199042 Thap1 THAP domain containing, apoptosis associated protein 1 0.78 NM_145585 Thumpd1 THUMP domain containing 1 0.72 NM_174989 Ticam1 Toll-like receptor adaptor molecule 1 0.78 NM_013897 Timm8b Translocase of inner mitochondrial membrane 8 homolog b (yeast) 0.75 NM_080639 Timp4 Tissue inhibitor of 4 0.78 NM_013769 Tjp3 Tight junction protein 3 0.76 NM_011599 Tle1 Transducin-like enhancer of split 1, homolog of Drosophila E(spl) 0.75 NM_175145 Tmem127 Transmembrane protein 127 0.61 NM_172885 Tmem132d Transmembrane protein 132D 0.71 NM_175187 Tmem161b Transmembrane protein 161B 0.66 NM_025339 Tmem42 Transmembrane protein 42 0.78 NM_177601 Tmem60 Transmembrane protein 60 0.73 NM_175502 Tmem74 Transmembrane protein 74 0.76 NM_026571 Tmhs Tetraspan transmembrane protein, hair cell stereocilia 0.72 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein 0.72 NM_009413 Tpd52l1 Tumor protein D52-like 1 0.75 NM_009423 Traf4 Tnf receptor associated factor 4 0.77 NM_198020 Trmt1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 0.78 NM_177781 Trpa1 Transient receptor potential cation channel, subfamily A, member 1 0.71 NM_011646 Try4 Trypsin 4 0.77 NM_022887 Tsc1 Tuberous sclerosis 1 0.78 NM_025359 Tspan13 Tetraspanin 13 0.76 NM_019571 Tspan5 Tetraspanin 5 0.78 NM_019634 Tspan7 Tetraspanin 7 0.74 NM_032004 Tssk6 Testis-specific serine kinase 6 0.76 NM_153600 Ttc26 Tetratricopeptide repeat domain 26 0.76 NM_013697 Ttr Transthyretin 0.76 NM_001033879 Tubal3 Tubulin, alpha-like 3 0.71 NM_001039157 Ube2j2 Ubiquitin-conjugating enzyme E2, J2 homolog (yeast) 0.74 NM_019949 Ube2l6 Ubiquitin-conjugating enzyme E2L 6 0.73

76 NM_054093 Ube3b Ubiquitin protein ligase E3B 0.72 NM_152234 Ubqln1 Ubiquilin 1 0.72 NM_053215 Ugt2b37 UDP glucuronosyltransferase 2 family, polypeptide B37 0.76 NM_009467 Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.72 NM_133952 Unc45a Unc-45 homolog A (C. elegans) 0.70 NM_025407 Uqcrc1 Ubiquinol-cytochrome c reductase core protein 1 0.78 NM_028846 Usp20 Ubiquitin specific peptidase 20 0.71 NM_133758 Usp47 Ubiquitin specific peptidase 47 0.74 NM_001013378 Uspl1 Ubiquitin specific peptidase like 1 0.73 NM_134165 V1rc10 Vomeronasal 1 receptor, C10 0.70 NM_053232 V1rc2 Vomeronasal 1 receptor, C2 0.76 NM_134181 V1rc26 Vomeronasal 1 receptor, C26 0.73 NM_030736 V1rd14 Vomeronasal 1 receptor, D14 0.75 NM_206869 V1rd16 Vomeronasal 1 receptor, D16 0.72 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 0.77 NM_134196 V1re7 Vomeronasal 1 receptor, E7 0.71 NM_145842 V1re9 Vomeronasal 1 receptor, E9 0.68 NM_145844 V1rh2 Vomeronasal 1 receptor, H2 0.68 NM_134225 V1ri9 Vomeronasal 1 receptor, I9 0.71 NM_134226 V1rj2 Vomeronasal 1 receptor, J2 0.72 NM_019917 V2r1b Vomeronasal 2, receptor, 1b 0.73 NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) 0.78 NM_001004436 Wapal Wings apart-like homolog (Drosophila) 0.78 NM_026137 Wdr13 WD repeat domain 13 0.59 NM_172372 Wdr45 WD repeat domain 45 0.74 NM_146039 Wdr60 WD repeat domain 60 0.74 NM_001012723 Wfdc16 WAP four-disulfide core domain 16 0.76 NM_133213 Xpnpep2 X- (aminopeptidase P) 2, membrane-bound 0.76 NM_028816 Xpo6 Exportin 6 0.76 NM_145393 Ythdf2 YTH domain family 2 0.77 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, NM_011739 Ywhaq theta polypeptide 0.78 NM_028325 Zcchc12 Zinc finger, CCHC domain containing 12 0.77 NM_001033795 Zcchc16 Zinc finger, CCHC domain containing 16 0.75 NM_177027 Zcchc7 Zinc finger, CCHC domain containing 7 0.77 NM_011751 Zfp207 Zinc finger protein 207 0.78 NM_175557 Zfp384 Zinc finger protein 384 0.76 NM_026015 Zmat5 Zinc finger, matrin type 5 0.72 NM_028028 Zswim1 Zinc finger, SWIM domain containing 1 0.57 NM_012039 Zw10 ZW10 homolog (Drosophila), centromere/kinetochore protein 0.74 NM_183266 0.72 NM_177131 0.76 NM_177179 0.76 NM_025927 0.77 NM_178054 0.74 NM_001033216 0.77 NM_177339 0.71 NM_025756 0.76 NM_001001737 0.73 NM_027096 0.78 NM_025880 0.75 NM_001013781 0.77 NM_177029 0.73 NM_207259 0.75 NM_021898 0.77

SUPPLEMENTAL TABLE S5: Genes Demonstrating Common Altered Repressive DimethylK9/K27-H3 Methylation in the Social Defeat and Social Isolation Models (p<0.001)

77

Accession Number Symbol Name NM_053102 15-Sep Selenoprotein NM_025345 0610037P05Rik RIKEN cDNA 0610037P05 gene NM_026451 1600012H06Rik RIKEN cDNA 1600012H06 gene NM_198637 1700016K19Rik RIKEN cDNA 1700016K19 gene NM_026469 1700025D03Rik RIKEN cDNA 1700025D03 gene NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene NM_026096 1700054O13Rik RIKEN cDNA 1700054O13 gene NM_029714 1700067C01Rik RIKEN cDNA 1700067C01 gene NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene NM_133829 2210010L05Rik RIKEN cDNA 2210010L05 gene NM_197999 2210023G05Rik RIKEN cDNA 2210023G05 gene NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene NM_026455 2510049I19Rik RIKEN cDNA 2510049I19 gene NM_183220 2610203E10Rik RIKEN cDNA 2610203E10 gene NM_025849 3110001D03Rik RIKEN cDNA 3110001D03 gene NM_177087 4632412N22Rik RIKEN cDNA 4632412N22 gene NM_172753 4732435N03Rik RIKEN cDNA 4732435N03 gene NM_025737 4931417E11Rik RIKEN cDNA 4931417E11 gene NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene NM_001033775 4933422H20Rik RIKEN cDNA 4933422H20 gene NM_001033424 5031408O05Rik RIKEN cDNA 5031408O05 gene NM_175165 5430420C16Rik RIKEN cDNA 5430420C16 gene NM_178801 6030446N20Rik RIKEN cDNA 6030446N20 gene NM_001039586 6230410P16Rik RIKEN cDNA 6230410P16 gene NM_178689 6430537H07Rik RIKEN cDNA 6430537H07 gene NM_030135 8030411F24Rik RIKEN cDNA 8030411F24 gene NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene NM_146217 Aars Alanyl-tRNA synthetase NM_008830 Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 NM_008992 Abcd4 ATP-binding cassette, sub-family D (ALD), member 4 NM_030239 Abcg3 ATP-binding cassette, sub-family G (WHITE), member 3 NM_146197 Acsm2 Acyl-CoA synthetase medium-chain family member 2 NM_025271 Actl7b Actin-like 7b NM_033268 Actn2 Actinin alpha 2 NM_020330 Adam21 A disintegrin and metallopeptidase domain 21 NM_031185 Akap12 A kinase (PRKA) anchor protein (gravin) 12 NM_010241 Aktip Thymoma viral proto-oncogene 1 interacting protein NM_178713 Aldh8a1 Aldehyde dehydrogenase 8 family, member A1 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 NM_001033303 Ampd1 Adenosine monophosphate deaminase 1 (isoform M) NM_007446 Amy1 Amylase 1, salivary NM_008486 Anpep Alanyl (membrane) aminopeptidase NM_175731 Asah3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 NM_175650 Atp13a5 ATPase type 13A5 NM_007507 Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e NM_199313 AY053573 CDNA sequence AY053573 NM_001018019 AY616753 CDNA sequence, AY616753 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene NM_001008549 BC043301 CDNA sequence BC043301 NM_207524 BC049702 CDNA sequence BC049702 NM_181419 BC050092 CDNA sequence BC050092 NM_026602 Bcas2 Breast carcinoma amplified sequence 2 NM_008528 Blnk B-cell linker NM_009756 Bmp10 Bone morphogenetic protein 10 NM_009763 Bst1 Bone marrow stromal cell antigen 1 NM_198095 Bst2 Bone marrow stromal cell antigen 2

78 NM_001037719 Btla B and T lymphocyte associated NM_177110 C130023O10Rik RIKEN cDNA C130023O10 gene NM_177110 C130023O10Rik RIKEN cDNA C130023O10 gene NM_020558 C1d Nuclear DNA binding protein NM_009779 C3ar1 Complement component 3a receptor 1 NM_145368 C730036D15Rik RIKEN cDNA C730036D15 gene NM_011274 C80913 Expressed sequence C80913 NM_133882 C8b Complement component 8, beta subunit NM_178396 Car12 Carbonic anyhydrase 12 NM_009809 Casp14 Caspase 14 NM_007617 Cav3 Caveolin 3 NM_021609 Ccbp2 Chemokine binding protein 2 NM_175369 Ccdc122 Coiled-coil domain containing 122 NM_175430 Ccdc40 Coiled-coil domain containing 40 NM_001012309 Ccdc55 Coiled-coil domain containing 55 NM_201372 Ccdc84 Coiled-coil domain containing 84 NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 NM_019577 Ccl24 Chemokine (C-C motif) ligand 24 NM_011338 Ccl9 Chemokine (C-C motif) ligand 9 NM_007718 Ccr1l1 Chemokine (C-C motif) receptor 1-like 1 NM_134158 Cd300d Cd300D antigen NM_013489 Cd84 CD84 antigen NM_009861 Cdc42 Cell division cycle 42 homolog (S. cerevisiae) NM_025496 Cdrt4 CMT1A duplicated region transcript 4 NM_144815 Cecr5 Cat eye syndrome chromosome region, candidate 5 homolog (human) NM_177150 Cenpt Centromere protein T NM_145603 Ces2 Carboxylesterase 2 NM_053200 Ces3 Carboxylesterase 3 NM_009892 Chi3l3 Chitinase 3-like 3 NM_145126 Chi3l4 Chitinase 3-like 4 NM_203491 Chrm2 Cholinergic receptor, muscarinic 2, cardiac NM_021439 Chst11 Carbohydrate sulfotransferase 11 NM_009899 Clca1 Chloride channel calcium activated 1 NM_139148 Clca4 Chloride channel calcium activated 4 NM_001007223 Clec3a C-type lectin domain family 3, member a NM_009907 Cln3 Ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) NM_019649 Clptm1 Cleft lip and palate associated transmembrane protein 1 NM_053096 Cml2 Camello-like 2 NM_027022 Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A NM_025771 Cntnap2 Contactin associated protein-like 2 NM_029635 Commd9 COMM domain containing 9 NM_015827 Copb2 Coatomer protein complex, subunit beta 2 (beta prime) NM_030205 Coro7 Coronin 7 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc NM_009953 Crhr2 Corticotropin releasing hormone receptor 2 NM_031402 Crispld1 Cysteine-rich secretory protein LCCL domain containing 1 NM_007778 Csf1 Colony stimulating factor 1 (macrophage) NM_027874 Csnk1d Casein kinase 1, delta NM_030059 Cst11 Cystatin 11 NM_009983 Ctsd Cathepsin D NM_009997 Cyp2a4 Cytochrome P450, family 2, subfamily a, polypeptide 4 NM_007812 Cyp2a5 Cytochrome P450, family 2, subfamily a, polypeptide 5 NM_009999 Cyp2b10 Cytochrome P450, family 2, subfamily b, polypeptide 10 NM_010006 Cyp2d9 Cytochrome P450, family 2, subfamily d, polypeptide 9 NM_013809 Cyp2g1 Cytochrome P450, family 2, subfamily g, polypeptide 1 NM_017396 Cyp3a41a Cytochrome P450, family 3, subfamily a, polypeptide 41A NM_017396 Cyp3a41a Cytochrome P450, family 3, subfamily a, polypeptide 41A NM_130882 Cyp4f13 Cytochrome P450, family 4, subfamily f, polypeptide 13

79 NM_008455 Cyp4v3 Cytochrome P450, family 4, subfamily v, polypeptide 3 NM_016890 Dctn3 Dynactin 3 NM_199080 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 NM_183038 Defb39 Defensin beta 39 NM_153108 Defb8 Defensin beta 8 NM_026191 Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 NM_007870 Dnase1l3 Deoxyribonuclease 1-like 3 NM_007887 Dub1 Deubiquitinating enzyme 1 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene NM_177593 EG210155 Predicted gene, EG210155 NM_001033767 EG240327 Predicted gene, EG240327 NM_001004158 EG380907 Predicted gene, EG380907 NM_001004162 EG432436 Predicted gene, EG432436 NM_001034882 EG432879 Predicted gene, EG432879 NM_001004182 EG434008 Predicted gene, EG434008 NM_001034102 EG545047 Predicted gene, EG545047 NM_001039119 EG654453 Predicted gene, EG654453 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) NM_016885 Emcn Endomucin NM_001025388 Eno1 Enolase 1, alpha non-neuron NM_001030291 Enpp7 Ectonucleotide pyrophosphatase/phosphodiesterase 7 NM_007946 Epx Eosinophil peroxidase NM_025513 Exosc3 Exosome component 3 NM_028066 F11 Coagulation factor XI NM_010170 F2rl2 Coagulation factor II (thrombin) receptor-like 2 NM_001029984 Fcrlb Fc receptor-like B NM_015759 Fgd3 FYVE, RhoGEF and PH domain containing 3 NM_172731 Fgd5 FYVE, RhoGEF and PH domain containing 5 NM_178382 Flrt3 Fibronectin leucine rich transmembrane protein 3 NM_177091 Fndc7 Fibronectin type III domain containing 7 NM_172673 Frmd5 FERM domain containing 5 NM_008047 Fstl1 Follistatin-like 1 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 NM_139197 Gbgt1 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 NM_008120 Gja4 Gap junction membrane channel protein alpha 4 NM_175681 Glp2r Glucagon-like peptide 2 receptor NM_198612 Glt8d4 Glycosyltransferase 8 domain containing 4 NM_001033473 Gm1157 Gene model 1157, (NCBI) NM_001033252 Gm732 Gene model 732, (NCBI) NM_027352 Gorasp2 Golgi reassembly stacking protein 2 NM_001033493 Gpr111 G protein-coupled receptor 111 NM_008159 Gpr33 G protein-coupled receptor 33 NM_022320 Gpr35 G protein-coupled receptor 35 NM_011938 Grk6 G protein-coupled receptor kinase 6 NM_029727 Gsdm2 Gasdermin 2 NM_026764 Gstm4 Glutathione S-transferase, mu 4 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 NM_025332 Gtpbp8 GTP-binding protein 8 (putative) NM_145067 Gucy2c Guanylate cyclase 2c NM_177635 H2-M11 Histocompatibility 2, M region locus 11 NM_008205 H2-M9 Histocompatibility 2, M region locus 9 NM_011827 Hcst Hematopoietic cell signal transducer NM_010417 Heph Hephaestin NM_013547 Hgd Homogentisate 1, 2-dioxygenase NM_010377 Hist1h1t Histone cluster 1, H1t NM_198090 Hnrpa3 Heterogeneous nuclear ribonucleoprotein A3 NM_028752 Hvcn1 Hydrogen voltage-gated channel 1

80 NM_177197 Idi2 Isopentenyl-diphosphate delta isomerase 2 NM_133871 Ifi44 Interferon-induced protein 44 NM_026820 Ifitm1 Interferon induced transmembrane protein 1 NM_028742 Ifltd1 Intermediate filament tail domain containing 1 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 NM_010546 Ikbkb Inhibitor of kappaB kinase beta NM_010551 Il16 Interleukin 16 NM_008364 Il1rap Interleukin 1 receptor accessory protein NM_010743 Il1rl1 Interleukin 1 receptor-like 1 NM_178241 Il8ra Interleukin 8 receptor, alpha NM_023343 Ilkap Integrin-linked kinase-associated serine/threonine phosphatase 2C NM_001024617 Inpp4b Inositol polyphosphate-4-phosphatase, type II NM_010566 Inpp5d Inositol polyphosphate-5-phosphatase D NM_008386 Ins1 Insulin I NM_022655 Ireb2 Iron responsive element binding protein 2 NM_001029872 Itgad Integrin, alpha D NM_008401 Itgam Integrin alpha M NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 NM_010587 Itsn1 Intersectin 1 (SH3 domain protein 1A) NM_030887 Jundm2 Jun dimerization protein 2 NM_134471 Kif2c Kinesin family member 2C NM_178260 Kiss1 KiSS-1 metastasis-suppressor NM_178771 Klhl26 Kelch-like 26 (Drosophila) NM_020268 Klk1b27 Kallikrein 1-related peptidase b27 NM_008463 Klra5 Killer cell lectin-like receptor, subfamily A, member 5 NM_010653 Klrc2 Killer cell lectin-like receptor subfamily C, member 2 NM_010665 Krt32 Keratin 32 NM_027983 Krt33a Keratin 33A NM_213730 Krt39 Keratin 39 NM_008475 Krt4 Keratin 4 NM_133892 Lao1 L-amino acid oxidase 1 NM_025420 Lce1m Late cornified envelope 1M NM_008280 Lipc Lipase, hepatic NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 NM_001039646 LOC626578 Macrophage activation 2 like LOC626578 NM_001033346 Lrrc55 Leucine rich repeat containing 55 NM_028915 Lrrcc1 Leucine rich repeat and coiled-coil domain containing 1 NM_019391 Lsp1 Lymphocyte specific 1 NM_010741 Ly6c1 Lymphocyte antigen 6 complex, locus C1 NM_153121 Lysmd1 LysM, putative peptidoglycan-binding, domain containing 1 NM_001013802 Macrod2 MACRO domain containing 2 NM_025649 Mad2l1bp MAD2L1 binding protein NM_020017 Magea3 Melanoma antigen, family A, 3 NM_020280 Magea4 Melanoma antigen, family A, 4 NM_031171 Mageb2 Melanoma antigen, family B, 2 NM_031171 Mageb2 Melanoma antigen, family B, 2 NM_001003913 Mars Methionine-tRNA synthetase NM_025676 Mcm8 Minichromosome maintenance deficient 8 (S. cerevisiae) NM_010786 Mdm2 Transformed mouse 3T3 cell double minute 2 NM_172499 Mfsd9 Major facilitator superfamily domain containing 9 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, NM_026243 Mgat4c isozyme C (putative) NM_001017393 MGC107098 Similar to spermiogenesis specific transcript on the Y 2 NM_001017393 MGC107098 Similar to spermiogenesis specific transcript on the Y 2 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase NM_177321 Mia2 Melanoma inhibitory activity 2 NM_010798 Mif Macrophage migration inhibitory factor NM_026143 Mlstd2 Male sterility domain containing 2 NM_026178 Mmd Monocyte to macrophage differentiation-associated

81 NM_032007 Mmp1b Matrix metallopeptidase 1b (interstitial collagenase) NM_001033450 Mnda Myeloid cell nuclear differentiation antigen NM_172610 Mpped1 Metallophosphoesterase domain containing 1 NM_205810 Mrgprb1 MAS-related GPR, member B1 NM_011288 Mrpl23 Mitochondrial ribosomal protein L23 NM_008630 Mt2 Metallothionein 2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent), NM_138745 Mthfd1 methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase NM_028860 Mtmr3 Myotubularin related protein 3 NM_001039544 Mup3 Major urinary protein 3 NM_008649 Mup5 Major urinary protein 5 NM_010874 Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) NM_031186 Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 NM_017464 Nedd9 Neural precursor cell expressed, developmentally down-regulated gene 9 NM_178071 Nme7 Non-metastatic cells 7, protein expressed in NM_145857 Nod2 Nucleotide-binding oligomerization domain containing 2 NM_139051 Nr5a1 Nuclear receptor subfamily 5, group A, member 1 NM_011955 Nubp1 Nucleotide binding protein 1 NM_013745 Nufip1 Nuclear fragile X mental retardation protein interacting protein 1 NM_001011774 Olfr1028 Olfactory receptor 1028 NM_146588 Olfr1030 Olfactory receptor 1030 NM_147017 Olfr1045 Olfactory receptor 1045 NM_001011735 Olfr1066 Olfactory receptor 1066 NM_147030 Olfr1134 Olfactory receptor 1134 NM_146647 Olfr1154 Olfactory receptor 1154 NM_146849 Olfr1157 Olfactory receptor 1157 NM_001005227 Olfr1200 Olfactory receptor 1200 NM_146978 Olfr1258 Olfactory receptor 1258 NM_146402 Olfr1303 Olfactory receptor 1303 NM_207240 Olfr1320 Olfactory receptor 1320 NM_146283 Olfr1366 Olfactory receptor 1366 NM_207573 Olfr1380 Olfactory receptor 1380 NM_147065 Olfr1390 Olfactory receptor 1390 NM_146276 Olfr1394 Olfactory receptor 1394 NM_001011839 Olfr1437 Olfactory receptor 1437 NM_146701 Olfr1448 Olfactory receptor 1448 NM_001011831 Olfr1500 Olfactory receptor 1500 NM_013728 Olfr154 Olfactory receptor 154 NM_001001809 Olfr218 Olfactory receptor 218 NM_146429 Olfr223 Olfactory receptor 223 NM_001011752 Olfr293 Olfactory receptor 293 NM_146942 Olfr351 Olfactory receptor 351 NM_146710 Olfr398 Olfactory receptor 398 NM_146711 Olfr43 Olfactory receptor 43 NM_146718 Olfr430 Olfactory receptor 430 NM_146295 Olfr446 Olfactory receptor 446 NM_146445 Olfr450 Olfactory receptor 450 NM_146987 Olfr457 Olfactory receptor 457 NM_010990 Olfr48 Olfactory receptor 48 NM_146914 Olfr5 Olfactory receptor 5 NM_146519 Olfr530 Olfactory receptor 530 NM_001011815 Olfr533 Olfactory receptor 533 NM_146962 Olfr541 Olfactory receptor 541 NM_147115 Olfr578 Olfactory receptor 578 NM_001011793 Olfr598 Olfactory receptor 598 NM_147080 Olfr615 Olfactory receptor 615 NM_146315 Olfr62 Olfactory receptor 62 NM_147119 Olfr632 Olfactory receptor 632 NM_146820 Olfr655 Olfactory receptor 655

82 NM_147060 Olfr667 Olfactory receptor 667 NM_146668 Olfr739 Olfactory receptor 739 NM_146729 Olfr784 Olfactory receptor 784 NM_146931 Olfr796 Olfactory receptor 796 NM_146782 Olfr921 Olfactory receptor 921 NM_001011813 Olfr93 Olfactory receptor 93 NM_146507 Olfr944 Olfactory receptor 944 NM_146612 Olfr968 Olfactory receptor 968 NM_146608 Olfr984 Olfactory receptor 984 NM_178657 Oog1 Oogenesin 1 NM_201258 Oog3 Oogenesin 3 NM_013887 Opn4 Opsin 4 (melanopsin) NM_011012 Oprl1 Opioid receptor-like 1 NM_145517 Ormdl1 ORM1-like 1 (S. cerevisiae) NM_001009550 OTTMUSG00000000231 Predicted gene, OTTMUSG00000000231 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 NM_001025574 OTTMUSG00000015915 Predicted gene, OTTMUSG00000015915 NM_007696 Ovgp1 Oviductal glycoprotein 1 NM_001001490 Oxgr1 Oxoglutarate (alpha-ketoglutarate) receptor 1 NM_053182 Pag1 Phosphoprotein associated with glycosphingolipid microdomains 1 NM_026701 Pbld Phenazine biosynthesis-like protein domain containing NM_053140 Pcdhb15 Protocadherin beta 15 NM_013628 Pcsk1 Proprotein convertase subtilisin/kexin type 1 NM_153422 Pde5a Phosphodiesterase 5A, cGMP-specific NM_033614 Pde6c Phosphodiesterase 6C, cGMP specific, cone, alpha prime NM_172263 Pde8b Phosphodiesterase 8B NM_008811 Pdha2 Pyruvate dehydrogenase E1 alpha 2 NM_011868 Peci Peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase NM_023041 Pex19 Peroxisome biogenesis factor 19 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 NM_177905 Piwil4 Piwi-like homolog 4 (Drosophila) NM_011107 Pla2g1b Phospholipase A2, group IB, pancreas NM_148937 Plcd4 Phospholipase C, delta 4 NM_025928 Pmf1 Polyamine-modulated factor 1 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 NM_011136 Pou2af1 POU domain, class 2, associating factor 1 NM_015817 Ppap2c Phosphatidic acid phosphatase type 2c NM_008014 Ppm1g Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform NM_016703 Preb Prolactin regulatory element binding NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 NM_028447 Prrc1 Proline-rich coiled-coil 1 NM_009430 Prss2 Protease, serine, 2 NM_029928 Ptprb Protein tyrosine phosphatase, receptor type, B NM_178595 Ptrh1 Peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) NM_009826 Rb1cc1 RB1-inducible coiled-coil 1 NM_198302 Rbm11 RNA binding motif protein 11 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 NM_009034 Rbp2 Retinol binding protein 2, cellular NM_153171 Rgs13 Regulator of G-protein signaling 13 NM_201236 Rhox4e Reproductive homeobox 4E NM_009543 Rnf103 Ring finger protein 103 NM_183280 RP23-438H3.2 Hypothetical protein LOC69357 NM_183280 RP23-438H3.2 Hypothetical protein LOC69357 NM_025393 S100a14 S100 calcium binding protein A14 NM_172205 Sbsn Suprabasin

83 NM_178672 Scfd2 Sec1 family domain containing 2 NM_133704 Sec22a SEC22 vesicle trafficking protein-like A (S. cerevisiae) NM_145373 Sectm1a Secreted and transmembrane 1A NM_011347 Selp Selectin, platelet Sema domain, transmembrane domain (TM), and cytoplasmic domain, NM_199238 Sema6d (semaphorin) 6D NM_146003 Senp6 SUMO/sentrin specific peptidase 6 NM_173024 Serpina3b Serine (or cysteine) peptidase inhibitor, clade A, member 3B NM_008458 Serpina3c Serine (or cysteine) peptidase inhibitor, clade A, member 3C NM_173052 Serpinb1b Serine (or cysteine) peptidase inhibitor, clade B, member 1b NM_080844 Serpinc1 Serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 NM_001013370 Sesn1 Sestrin 1 NM_172788 Sh3md4 SH3 multiple domains 4 NM_144539 Slamf7 SLAM family member 7 NM_029612 Slamf9 SLAM family member 9 NM_177016 Slc17a4 Solute carrier family 17 (sodium phosphate), member 4 NM_008766 Slc22a6 Solute carrier family 22 (organic anion transporter), member 6 NM_177243 Slc26a9 Solute carrier family 26, member 9 NM_134060 Slc35b3 Solute carrier family 35, member B3 NM_033314 Slco2a1 Solute carrier organic anion transporter family, member 2a1 NM_175316 Slco2b1 Solute carrier organic anion transporter family, member 2b1 NM_028534 Smap1 Stromal membrane-associated protein 1 NM_011366 Sorbs3 Sorbin and SH3 domain containing 3 NM_025668 Spcs2 Signal peptidase complex subunit 2 homolog (S. cerevisiae) NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) NM_009258 Spink3 Serine peptidase inhibitor, Kazal type 3 NM_011469 Sprr2b Small proline-rich protein 2B NM_011478 Sprr3 Small proline-rich protein 3 NM_020611 Srd5a2l Steroid 5 alpha-reductase 2-like NM_199319 Ssxb5 Synovial sarcoma, X member B, breakpoint 5 NM_173869 Stfa2l1 Stefin A2 like 1 NM_009185 Stil Scl/Tal1 interrupting locus NM_026474 Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) NM_001040086 Sytl2 Synaptotagmin-like 2 NM_028769 Syvn1 Synovial apoptosis inhibitor 1, synoviolin NM_207028 Tas2r126 Taste receptor, type 2, member 126 NM_199159 Tas2r135 Taste receptor, type 2, member 135 NM_013775 Tcl1b2 T-cell leukemia/lymphoma 1B, 2 NM_009341 Tcp10c T-complex protein 10c NM_198292 Tex2 Testis expressed gene 2 NM_028799 Tgm5 Transglutaminase 5 NM_025458 Tmed6 Transmembrane emp24 protein transport domain containing 6 NM_153589 Tmem16b Transmembrane protein 16B NM_133706 Tmem97 Transmembrane protein 97 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein NM_172843 Tor1aip2 Torsin A interacting protein 2 NM_009417 Tpo Thyroid peroxidase NM_001024206 Trappc1 Trafficking protein particle complex 1 NM_001007572 Trpv5 Transient receptor potential cation channel, subfamily V, member 5 NM_199033 Tsen2 TRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) NM_019634 Tspan7 Tetraspanin 7 NM_011652 Ttn Titin NM_153519 Txndc2 Thioredoxin domain containing 2 (spermatozoa) NM_011662 Tyrobp TYRO protein tyrosine kinase binding protein NM_019949 Ube2l6 Ubiquitin-conjugating enzyme E2L 6 NM_053215 Ugt2b37 UDP glucuronosyltransferase 2 family, polypeptide B37 NM_009467 Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 NM_025407 Uqcrc1 Ubiquinol-cytochrome c reductase core protein 1 NM_053221 V1ra6 Vomeronasal 1 receptor, A6

84 NM_053228 V1rb7 Vomeronasal 1 receptor, B7 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 NM_134169 V1rc14 Vomeronasal 1 receptor, C14 NM_053232 V1rc2 Vomeronasal 1 receptor, C2 NM_134183 V1rc28 Vomeronasal 1 receptor, C28 NM_030736 V1rd14 Vomeronasal 1 receptor, D14 NM_206869 V1rd16 Vomeronasal 1 receptor, D16 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 NM_009502 Vcl Vinculin NM_175936 Vmn2r81 Vomeronasal 2, receptor 81 NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) NM_172120 Vps41 Vacuolar protein sorting 41 (yeast) NM_025362 Wbscr18 Williams-Beuren syndrome chromosome region 18 homolog (human) NM_026137 Wdr13 WD repeat domain 13 NM_021365 Xlr4b X-linked lymphocyte-regulated 4B NM_183094 Xlr4b X-linked lymphocyte-regulated 4B NM_199304 Zfp341 Zinc finger protein 341 NM_001001737 NM_001002772 NM_001013752 NM_001013781 NM_001024470 NM_001033814 NM_008835 NM_020295 NM_020609 NM_026230 NM_134211 NM_172792 NM_177179 NM_177895 NM_183108

SUPPLEMENTAL TABLE S6: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat and Social Isolation Models (p<0.001)

Accession Defeat Fold Isolation Fold Number Symbol Name Change Change NM_053102 15-Sep Selenoprotein 1.52 1.47 NM_025345 0610037P05Rik RIKEN cDNA 0610037P05 gene 1.51 1.35 NM_198637 1700016K19Rik RIKEN cDNA 1700016K19 gene 1.44 1.66 NM_026469 1700025D03Rik RIKEN cDNA 1700025D03 gene 1.55 1.39 NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene 1.63 1.41 NM_026096 1700054O13Rik RIKEN cDNA 1700054O13 gene 1.65 1.48 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 1.55 1.40 NM_133829 2210010L05Rik RIKEN cDNA 2210010L05 gene 1.60 1.35 NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene 1.68 1.38 NM_177087 4632412N22Rik RIKEN cDNA 4632412N22 gene 1.55 1.40 NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene 1.58 1.35 NM_001033775 4933422H20Rik RIKEN cDNA 4933422H20 gene 1.49 1.49 NM_001033424 5031408O05Rik RIKEN cDNA 5031408O05 gene 1.48 1.39 NM_001039586 6230410P16Rik RIKEN cDNA 6230410P16 gene 1.41 1.43 NM_178689 6430537H07Rik RIKEN cDNA 6430537H07 gene 1.50 1.41 NM_030135 8030411F24Rik RIKEN cDNA 8030411F24 gene 1.57 1.52 NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene 1.94 1.41 NM_146217 Aars Alanyl-tRNA synthetase 1.42 1.37 ATP-binding cassette, sub-family B (MDR/TAP), NM_008830 Abcb4 member 4 1.53 1.35

85 Acyl-CoA synthetase medium-chain family member NM_146197 Acsm2 2 1.43 1.43 NM_025271 Actl7b Actin-like 7b 1.77 1.35 NM_033268 Actn2 Actinin alpha 2 1.51 1.45 NM_010241 Aktip Thymoma viral proto-oncogene 1 interacting protein 1.56 1.37 NM_178713 Aldh8a1 Aldehyde dehydrogenase 8 family, member A1 1.46 1.32 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 1.44 1.34 NM_008486 Anpep Alanyl (membrane) aminopeptidase 1.46 1.43 N-acylsphingosine amidohydrolase (alkaline NM_175731 Asah3 ceramidase) 3 1.58 1.49 NM_175650 Atp13a5 ATPase type 13A5 1.42 1.36 NM_001018019 AY616753 CDNA sequence, AY616753 1.70 1.52 NM_001008549 BC043301 CDNA sequence BC043301 1.68 1.35 NM_207524 BC049702 CDNA sequence BC049702 1.52 1.42 NM_008528 Blnk B-cell linker 1.42 1.32 NM_009756 Bmp10 Bone morphogenetic protein 10 1.44 1.48 NM_011274 C80913 Expressed sequence C80913 1.68 1.41 NM_133882 C8b Complement component 8, beta subunit 1.54 1.36 NM_178396 Car12 Carbonic anyhydrase 12 1.41 1.33 NM_009809 Casp14 Caspase 14 1.59 1.43 NM_007617 Cav3 Caveolin 3 1.44 1.36 NM_021609 Ccbp2 Chemokine binding protein 2 1.42 1.33 NM_175369 Ccdc122 Coiled-coil domain containing 122 1.44 1.50 NM_175430 Ccdc40 Coiled-coil domain containing 40 1.59 1.48 NM_001012309 Ccdc55 Coiled-coil domain containing 55 1.42 1.35 NM_201372 Ccdc84 Coiled-coil domain containing 84 1.52 1.34 NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 1.62 1.41 NM_019577 Ccl24 Chemokine (C-C motif) ligand 24 1.64 1.45 NM_007718 Ccr1l1 Chemokine (C-C motif) receptor 1-like 1 1.48 1.35 NM_134158 Cd300d Cd300D antigen 1.41 1.36 NM_013489 Cd84 CD84 antigen 1.53 1.32 NM_025496 Cdrt4 CMT1A duplicated region transcript 4 1.76 1.39 Cat eye syndrome chromosome region, candidate 5 NM_144815 Cecr5 homolog (human) 1.42 1.38 NM_177150 Cenpt Centromere protein T 1.62 1.35 NM_145603 Ces2 Carboxylesterase 2 1.57 1.46 NM_053200 Ces3 Carboxylesterase 3 1.41 1.51 NM_203491 Chrm2 Cholinergic receptor, muscarinic 2, cardiac 1.55 1.34 NM_021439 Chst11 Carbohydrate sulfotransferase 11 1.44 1.47 NM_009899 Clca1 Chloride channel calcium activated 1 1.44 1.36 NM_139148 Clca4 Chloride channel calcium activated 4 1.61 1.37 NM_001007223 Clec3a C-type lectin domain family 3, member a 1.56 1.33 Ceroid lipofuscinosis, neuronal 3, juvenile (Batten, NM_009907 Cln3 Spielmeyer-Vogt disease) 1.51 1.38 CKLF-like MARVEL transmembrane domain NM_027022 Cmtm2a containing 2A 1.42 1.38 NM_025771 Cntnap2 Contactin associated protein-like 2 1.50 1.37 NM_029635 Commd9 COMM domain containing 9 1.52 1.35 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 1.75 1.40 NM_009953 Crhr2 Corticotropin releasing hormone receptor 2 1.81 1.35 NM_007778 Csf1 Colony stimulating factor 1 (macrophage) 1.54 1.39 NM_027874 Csnk1d Casein kinase 1, delta 1.57 1.39 NM_030059 Cst11 Cystatin 11 1.49 1.36 Cytochrome P450, family 2, subfamily a, NM_009997 Cyp2a4 polypeptide 4 1.57 1.36 Cytochrome P450, family 2, subfamily a, NM_007812 Cyp2a5 polypeptide 5 1.48 1.37 Cytochrome P450, family 2, subfamily b, NM_009999 Cyp2b10 polypeptide 10 1.52 1.49 Cytochrome P450, family 2, subfamily d, NM_010006 Cyp2d9 polypeptide 9 1.48 1.37

86 Cytochrome P450, family 3, subfamily a, NM_017396 Cyp3a41a polypeptide 41A 1.43 1.37 Cytochrome P450, family 4, subfamily f, NM_130882 Cyp4f13 polypeptide 13 1.43 1.38 Cytochrome P450, family 4, subfamily v, NM_008455 Cyp4v3 polypeptide 3 1.50 1.44 NM_199080 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 1.68 1.35 NM_007870 Dnase1l3 Deoxyribonuclease 1-like 3 1.46 1.59 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 1.70 1.36 NM_177593 EG210155 Predicted gene, EG210155 1.41 1.34 NM_001004158 EG380907 Predicted gene, EG380907 1.52 1.48 NM_001004162 EG432436 Predicted gene, EG432436 1.47 1.42 NM_001004182 EG434008 Predicted gene, EG434008 1.44 1.35 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) 1.43 1.39 Ectonucleotide pyrophosphatase/phosphodiesterase NM_001030291 Enpp7 7 1.50 1.45 NM_007946 Epx Eosinophil peroxidase 1.45 1.53 NM_010170 F2rl2 Coagulation factor II (thrombin) receptor-like 2 1.63 1.33 NM_001029984 Fcrlb Fc receptor-like B 1.65 1.39 NM_015759 Fgd3 FYVE, RhoGEF and PH domain containing 3 1.51 1.32 NM_172731 Fgd5 FYVE, RhoGEF and PH domain containing 5 1.45 1.42 NM_008047 Fstl1 Follistatin-like 1 1.54 1.74 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 1.41 1.33 NM_008120 Gja4 Gap junction membrane channel protein alpha 4 1.43 1.38 NM_175681 Glp2r Glucagon-like peptide 2 receptor 1.42 1.39 NM_198612 Glt8d4 Glycosyltransferase 8 domain containing 4 1.41 1.61 NM_001033473 Gm1157 Gene model 1157, (NCBI) 1.50 1.34 NM_001033252 Gm732 Gene model 732, (NCBI) 1.58 1.43 NM_027352 Gorasp2 Golgi reassembly stacking protein 2 1.42 1.36 NM_001033493 Gpr111 G protein-coupled receptor 111 1.61 1.50 NM_008159 Gpr33 G protein-coupled receptor 33 1.52 1.43 NM_022320 Gpr35 G protein-coupled receptor 35 1.42 1.46 NM_011938 Grk6 G protein-coupled receptor kinase 6 1.49 1.40 NM_026764 Gstm4 Glutathione S-transferase, mu 4 1.55 1.32 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 1.46 1.37 NM_025332 Gtpbp8 GTP-binding protein 8 (putative) 1.52 1.38 NM_145067 Gucy2c Guanylate cyclase 2c 1.48 1.40 NM_177635 H2-M11 Histocompatibility 2, M region locus 11 1.50 1.43 NM_008205 H2-M9 Histocompatibility 2, M region locus 9 1.44 1.44 NM_011827 Hcst Hematopoietic cell signal transducer 1.54 1.45 NM_013547 Hgd Homogentisate 1, 2-dioxygenase 1.65 1.51 NM_010377 Hist1h1t Histone cluster 1, H1t 1.52 1.34 NM_028752 Hvcn1 Hydrogen voltage-gated channel 1 1.63 1.35 NM_177197 Idi2 Isopentenyl-diphosphate delta isomerase 2 1.41 1.38 NM_133871 Ifi44 Interferon-induced protein 44 1.47 1.43 NM_026820 Ifitm1 Interferon induced transmembrane protein 1 1.47 1.37 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 1.46 1.46 NM_010546 Ikbkb Inhibitor of kappaB kinase beta 1.75 1.34 NM_010551 Il16 Interleukin 16 1.57 1.34 NM_010743 Il1rl1 Interleukin 1 receptor-like 1 1.60 1.40 NM_178241 Il8ra Interleukin 8 receptor, alpha 1.44 1.38 Integrin-linked kinase-associated serine/threonine NM_023343 Ilkap phosphatase 2C 1.42 1.36 NM_001024617 Inpp4b Inositol polyphosphate-4-phosphatase, type II 1.48 1.35 NM_008386 Ins1 Insulin I 1.58 1.44 NM_022655 Ireb2 Iron responsive element binding protein 2 1.43 1.35 NM_001029872 Itgad Integrin, alpha D 1.54 1.42 NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 1.59 1.33 NM_010587 Itsn1 Intersectin 1 (SH3 domain protein 1A) 1.49 1.33 NM_030887 Jundm2 Jun dimerization protein 2 1.45 1.62

87 NM_134471 Kif2c Kinesin family member 2C 1.46 1.35 NM_178260 Kiss1 KiSS-1 metastasis-suppressor 1.45 1.46 NM_178771 Klhl26 Kelch-like 26 (Drosophila) 1.52 1.44 Killer cell lectin-like receptor subfamily C, member NM_010653 Klrc2 2 1.49 1.60 NM_010665 Krt32 Keratin 32 1.70 1.34 NM_027983 Krt33a Keratin 33A 1.46 1.48 NM_213730 Krt39 Keratin 39 1.58 1.51 NM_008475 Krt4 Keratin 4 1.48 1.35 NM_025420 Lce1m Late cornified envelope 1M 1.50 1.51 NM_008280 Lipc Lipase, hepatic 1.54 1.35 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 1.59 1.33 NM_001039646 LOC626578 Macrophage activation 2 like LOC626578 1.49 1.37 NM_001033346 Lrrc55 Leucine rich repeat containing 55 1.47 1.46 NM_019391 Lsp1 Lymphocyte specific 1 1.46 1.38 NM_010741 Ly6c1 Lymphocyte antigen 6 complex, locus C1 1.43 1.47 LysM, putative peptidoglycan-binding, domain NM_153121 Lysmd1 containing 1 1.52 1.37 NM_001013802 Macrod2 MACRO domain containing 2 1.55 1.40 NM_020017 Magea3 Melanoma antigen, family A, 3 1.68 1.38 NM_031171 Mageb2 Melanoma antigen, family B, 2 1.48 1.52 Minichromosome maintenance deficient 8 (S. NM_025676 Mcm8 cerevisiae) 1.52 1.33 NM_172499 Mfsd9 Major facilitator superfamily domain containing 9 1.41 1.52 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 1.59 1.44 NM_177321 Mia2 Melanoma inhibitory activity 2 1.44 1.45 NM_010798 Mif Macrophage migration inhibitory factor 1.44 1.38 NM_032007 Mmp1b Matrix metallopeptidase 1b (interstitial collagenase) 1.52 1.34 NM_001033450 Mnda Myeloid cell nuclear differentiation antigen 1.53 1.61 NM_172610 Mpped1 Metallophosphoesterase domain containing 1 1.79 1.50 NM_011288 Mrpl23 Mitochondrial ribosomal protein L23 1.57 1.47 NM_008630 Mt2 Metallothionein 2 1.50 1.37 NM_028860 Mtmr3 Myotubularin related protein 3 1.41 1.54 N-acetyltransferase 2 (arylamine N- NM_010874 Nat2 acetyltransferase) 1.71 1.39 Neural precursor cell expressed, developmentally NM_017464 Nedd9 down-regulated gene 9 1.41 1.32 NM_139051 Nr5a1 Nuclear receptor subfamily 5, group A, member 1 1.46 1.41 NM_011955 Nubp1 Nucleotide binding protein 1 1.52 1.37 NM_001011774 Olfr1028 Olfactory receptor 1028 1.46 1.37 NM_147017 Olfr1045 Olfactory receptor 1045 1.44 1.36 NM_001005227 Olfr1200 Olfactory receptor 1200 1.64 1.38 NM_146978 Olfr1258 Olfactory receptor 1258 1.48 1.54 NM_146283 Olfr1366 Olfactory receptor 1366 1.54 1.43 NM_147065 Olfr1390 Olfactory receptor 1390 1.43 1.35 NM_146276 Olfr1394 Olfactory receptor 1394 1.47 1.33 NM_001011839 Olfr1437 Olfactory receptor 1437 1.49 1.43 NM_146701 Olfr1448 Olfactory receptor 1448 1.46 1.36 NM_001011831 Olfr1500 Olfactory receptor 1500 1.47 1.39 NM_013728 Olfr154 Olfactory receptor 154 1.48 1.32 NM_001001809 Olfr218 Olfactory receptor 218 1.47 1.33 NM_146942 Olfr351 Olfactory receptor 351 1.57 1.40 NM_146710 Olfr398 Olfactory receptor 398 1.64 1.34 NM_146295 Olfr446 Olfactory receptor 446 1.52 1.42 NM_146445 Olfr450 Olfactory receptor 450 1.48 1.41 NM_146987 Olfr457 Olfactory receptor 457 1.60 1.41 NM_010990 Olfr48 Olfactory receptor 48 1.42 1.44 NM_146519 Olfr530 Olfactory receptor 530 1.45 1.48 NM_001011815 Olfr533 Olfactory receptor 533 1.65 1.47 NM_146962 Olfr541 Olfactory receptor 541 1.53 1.35

88 NM_147115 Olfr578 Olfactory receptor 578 1.56 1.41 NM_147080 Olfr615 Olfactory receptor 615 1.44 1.42 NM_146315 Olfr62 Olfactory receptor 62 1.55 1.35 NM_146820 Olfr655 Olfactory receptor 655 1.81 1.35 NM_147060 Olfr667 Olfactory receptor 667 1.59 1.37 NM_146729 Olfr784 Olfactory receptor 784 1.41 1.34 NM_146782 Olfr921 Olfactory receptor 921 1.58 1.37 NM_001011813 Olfr93 Olfactory receptor 93 1.41 1.45 NM_146507 Olfr944 Olfactory receptor 944 1.69 1.38 NM_146608 Olfr984 Olfactory receptor 984 1.53 1.43 NM_178657 Oog1 Oogenesin 1 1.65 1.41 NM_011012 Oprl1 Opioid receptor-like 1 1.42 1.43 NM_001025574 OTTMUSG00000015915 Predicted gene, OTTMUSG00000015915 1.53 1.51 NM_007696 Ovgp1 Oviductal glycoprotein 1 1.44 1.38 NM_001001490 Oxgr1 Oxoglutarate (alpha-ketoglutarate) receptor 1 1.65 1.50 Phosphoprotein associated with glycosphingolipid NM_053182 Pag1 microdomains 1 1.42 1.51 NM_153422 Pde5a Phosphodiesterase 5A, cGMP-specific 1.61 1.48 Phosphodiesterase 6C, cGMP specific, cone, alpha NM_033614 Pde6c prime 1.51 1.36 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 1.45 1.38 NM_011107 Pla2g1b Phospholipase A2, group IB, pancreas 1.50 1.50 NM_148937 Plcd4 Phospholipase C, delta 4 1.57 1.34 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 1.64 1.34 NM_011136 Pou2af1 POU domain, class 2, associating factor 1 1.45 1.57 NM_015817 Ppap2c Phosphatidic acid phosphatase type 2c 1.57 1.39 Protein phosphatase 1G (formerly 2C), magnesium- NM_008014 Ppm1g dependent, gamma isoform 1.59 1.43 NM_016703 Preb Prolactin regulatory element binding 1.68 1.45 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 1.56 1.44 NM_028447 Prrc1 Proline-rich coiled-coil 1 1.57 1.51 NM_009430 Prss2 Protease, serine, 2 1.81 1.40 NM_178595 Ptrh1 Peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) 1.56 1.49 NM_009034 Rbp2 Retinol binding protein 2, cellular 1.48 1.48 NM_201236 Rhox4e Reproductive homeobox 4E 1.51 1.43 NM_025393 S100a14 S100 calcium binding protein A14 1.47 1.36 NM_172205 Sbsn Suprabasin 1.71 1.36 NM_178672 Scfd2 Sec1 family domain containing 2 1.48 1.44 SEC22 vesicle trafficking protein-like A (S. NM_133704 Sec22a cerevisiae) 1.53 1.34 NM_145373 Sectm1a Secreted and transmembrane 1A 1.53 1.36 NM_011347 Selp Selectin, platelet 1.62 1.35 Sema domain, transmembrane domain (TM), and NM_199238 Sema6d cytoplasmic domain, (semaphorin) 6D 1.48 1.50 Serine (or cysteine) peptidase inhibitor, clade B, NM_173052 Serpinb1b member 1b 1.43 1.36 Serine (or cysteine) peptidase inhibitor, clade C NM_080844 Serpinc1 (antithrombin), member 1 1.43 1.42 NM_172788 Sh3md4 SH3 multiple domains 4 1.50 1.35 NM_144539 Slamf7 SLAM family member 7 1.47 1.38 NM_029612 Slamf9 SLAM family member 9 1.52 1.42 Solute carrier family 17 (sodium phosphate), NM_177016 Slc17a4 member 4 1.67 1.44 NM_177243 Slc26a9 Solute carrier family 26, member 9 1.60 1.40 NM_134060 Slc35b3 Solute carrier family 35, member B3 1.58 1.45 Solute carrier organic anion transporter family, NM_033314 Slco2a1 member 2a1 1.43 1.37 Solute carrier organic anion transporter family, NM_175316 Slco2b1 member 2b1 1.46 1.47 NM_028534 Smap1 Stromal membrane-associated protein 1 1.44 1.32 NM_011366 Sorbs3 Sorbin and SH3 domain containing 3 1.42 1.39 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 1.62 1.33

89 NM_009258 Spink3 Serine peptidase inhibitor, Kazal type 3 1.48 1.39 NM_011478 Sprr3 Small proline-rich protein 3 1.63 1.42 NM_020611 Srd5a2l Steroid 5 alpha-reductase 2-like 1.52 1.77 SGT1, suppressor of G2 allele of SKP1 (S. NM_026474 Sugt1 cerevisiae) 1.72 1.48 NM_207028 Tas2r126 Taste receptor, type 2, member 126 1.76 1.32 NM_199159 Tas2r135 Taste receptor, type 2, member 135 1.56 1.33 NM_028799 Tgm5 Transglutaminase 5 1.44 1.59 Transmembrane emp24 protein transport domain NM_025458 Tmed6 containing 6 1.66 1.49 NM_153589 Tmem16b Transmembrane protein 16B 1.48 1.51 NM_133706 Tmem97 Transmembrane protein 97 1.53 1.37 NM_001024206 Trappc1 Trafficking protein particle complex 1 1.44 1.38 Transient receptor potential cation channel, NM_001007572 Trpv5 subfamily V, member 5 1.63 1.33 TRNA splicing endonuclease 2 homolog (SEN2, S. NM_199033 Tsen2 cerevisiae) 1.50 1.38 NM_011652 Ttn Titin 1.42 1.41 NM_153519 Txndc2 Thioredoxin domain containing 2 (spermatozoa) 1.53 1.54 NM_011662 Tyrobp TYRO protein tyrosine kinase binding protein 1.47 1.49 NM_053221 V1ra6 Vomeronasal 1 receptor, A6 1.50 1.32 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 1.46 1.34 NM_134183 V1rc28 Vomeronasal 1 receptor, C28 1.50 1.36 NM_009502 Vcl Vinculin 1.63 1.35 NM_172120 Vps41 Vacuolar protein sorting 41 (yeast) 1.46 1.37 NM_021365 Xlr4b X-linked lymphocyte-regulated 4B 1.44 1.37 NM_199304 Zfp341 Zinc finger protein 341 1.62 1.36 NM_001024470 1.78 1.37 NM_001013752 1.59 1.45 NM_026230 1.54 1.35 NM_001033814 1.50 1.40 NM_020609 1.47 1.33 NM_183108 1.57 1.46 NM_177895 1.48 1.52 NM_008835 1.42 1.39 NM_001002772 1.74 1.33

SUPPLEMENTAL TABLE S7: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in the Social Defeat and Social Isolation Models (p<0.001)

Defeat Fold Isolation Fold Accession Number Symbol Name Change Change NM_026455 2510049I19Rik RIKEN cDNA 2510049I19 gene 0.71 0.76 NM_172753 4732435N03Rik RIKEN cDNA 4732435N03 gene 0.70 0.78 NM_020330 Adam21 A disintegrin and metallopeptidase domain 21 0.70 0.73 NM_199313 AY053573 CDNA sequence AY053573 0.61 0.77 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene 0.54 0.68 NM_181419 BC050092 CDNA sequence BC050092 0.72 0.76 NM_026602 Bcas2 Breast carcinoma amplified sequence 2 0.59 0.74 NM_198095 Bst2 Bone marrow stromal cell antigen 2 0.70 0.76 NM_011338 Ccl9 Chemokine (C-C motif) ligand 9 0.67 0.73 NM_145126 Chi3l4 Chitinase 3-like 4 0.60 0.72 NM_019649 Clptm1 Cleft lip and palate associated transmembrane protein 1 0.72 0.65 NM_053096 Cml2 Camello-like 2 0.41 0.77 NM_030205 Coro7 Coronin 7 0.55 0.73 NM_013809 Cyp2g1 Cytochrome P450, family 2, subfamily g, polypeptide 1 0.48 0.78 NM_007887 Dub1 Deubiquitinating enzyme 1 0.71 0.73 NM_001034882 EG432879 Predicted gene, EG432879 0.53 0.72 NM_001034102 EG545047 Predicted gene, EG545047 0.59 0.72 NM_025513 Exosc3 Exosome component 3 0.67 0.77

90 NM_178382 Flrt3 Fibronectin leucine rich transmembrane protein 3 0.72 0.76 NM_177091 Fndc7 Fibronectin type III domain containing 7 0.63 0.71 NM_029727 Gsdm2 Gasdermin 2 0.59 0.74 NM_010417 Heph Hephaestin 0.61 0.70 NM_008463 Klra5 Killer cell lectin-like receptor, subfamily A, member 5 0.63 0.69 NM_028915 Lrrcc1 Leucine rich repeat and coiled-coil domain containing 1 0.59 0.77 NM_025649 Mad2l1bp MAD2L1 binding protein 0.69 0.76 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- NM_026243 Mgat4c acetylglucosaminyltransferase, isozyme C (putative) 0.68 0.75 NM_205810 Mrgprb1 MAS-related GPR, member B1 0.69 0.73 NM_001039544 Mup3 Major urinary protein 3 0.50 0.78 NM_178071 Nme7 Non-metastatic cells 7, protein expressed in 0.68 0.66 Nuclear fragile X mental retardation protein interacting NM_013745 Nufip1 protein 1 0.73 0.76 NM_146588 Olfr1030 Olfactory receptor 1030 0.69 0.78 NM_001011735 Olfr1066 Olfactory receptor 1066 0.51 0.73 NM_146849 Olfr1157 Olfactory receptor 1157 0.60 0.74 NM_001011752 Olfr293 Olfactory receptor 293 0.70 0.71 NM_146612 Olfr968 Olfactory receptor 968 0.69 0.78 NM_001009550 OTTMUSG00000000231 Predicted gene, OTTMUSG00000000231 0.72 0.75 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.64 0.73 NM_026701 Pbld Phenazine biosynthesis-like protein domain containing 0.71 0.78 NM_025928 Pmf1 Polyamine-modulated factor 1 0.69 0.51 NM_009826 Rb1cc1 RB1-inducible coiled-coil 1 0.71 0.77 NM_183280 RP23-438H3.2 Hypothetical protein LOC69357 0.67 0.77 NM_146003 Senp6 SUMO/sentrin specific peptidase 6 0.51 0.67 NM_001013370 Sesn1 Sestrin 1 0.72 0.78 Solute carrier family 22 (organic anion transporter), NM_008766 Slc22a6 member 6 0.57 0.74 Signal peptidase complex subunit 2 homolog (S. NM_025668 Spcs2 cerevisiae) 0.72 0.78 NM_011469 Sprr2b Small proline-rich protein 2B 0.72 0.77 NM_173869 Stfa2l1 Stefin A2 like 1 0.68 0.63 NM_009185 Stil Scl/Tal1 interrupting locus 0.69 0.74 NM_013775 Tcl1b2 T-cell leukemia/lymphoma 1B, 2 0.68 0.74 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein 0.72 0.72 NM_053215 Ugt2b37 UDP glucuronosyltransferase 2 family, polypeptide B37 0.69 0.76 NM_009467 Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.56 0.72 NM_025407 Uqcrc1 Ubiquinol-cytochrome c reductase core protein 1 0.66 0.78 NM_053232 V1rc2 Vomeronasal 1 receptor, C2 0.54 0.76 NM_030736 V1rd14 Vomeronasal 1 receptor, D14 0.61 0.75 NM_206869 V1rd16 Vomeronasal 1 receptor, D16 0.55 0.72 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 0.59 0.77 NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) 0.59 0.78 NM_026137 Wdr13 WD repeat domain 13 0.67 0.59 NM_001001737 0.69 0.73

SUPPLEMENTAL TABLE S8: Genes Demonstrating Increased Phospho-CREB Binding in the Social Defeat Model (p<0.001)

Accession Number Symbol Name Fold Change NM_172606 6-Mar Membrane-associated ring finger (C3HC4) 6 2.26 NM_025806 1100001H23Rik RIKEN cDNA 1100001H23 gene 2.19 NM_178065 1110018G07Rik RIKEN cDNA 1110018G07 gene 2.16 NM_025431 1190005P17Rik RIKEN cDNA 1190005P17 gene 2.16 NM_025831 1300014I06Rik RIKEN cDNA 1300014I06 gene 2.71 NM_025892 1500031L02Rik RIKEN cDNA 1500031L02 gene 2.18 NM_029602 1700022C21Rik RIKEN cDNA 1700022C21 gene 2.12 NM_178619 1810026J23Rik RIKEN cDNA 1810026J23 gene 2.24 NM_025946 2010100O12Rik RIKEN cDNA 2010100O12 gene 2.47

91 NM_001025573 2010107G12Rik RIKEN cDNA 2010107G12 gene 2.68 NM_172398 2310005E10Rik RIKEN cDNA 2310005E10 gene 2.26 NM_025865 2310030G06Rik RIKEN cDNA 2310030G06 gene 2.13 NM_026655 2310057M21Rik RIKEN cDNA 2310057M21 gene 2.29 NM_025874 2310076L09Rik RIKEN cDNA 2310076L09 gene 2.18 NM_026643 2410017P07Rik RIKEN cDNA 2410017P07 gene 2.32 NM_028603 2410081M15Rik RIKEN cDNA 2410081M15 gene 2.12 NM_025997 2610204K14Rik RIKEN cDNA 2610204K14 gene 2.95 NM_183287 2610318N02Rik RIKEN cDNA 2610318N02 gene 2.29 NM_178399 3110035E14Rik RIKEN cDNA 3110035E14 gene 2.21 NM_027568 4733401H21Rik RIKEN cDNA 4733401H21 gene 2.91 NM_178388 4930425N13Rik RIKEN cDNA 4930425N13 gene 2.33 NM_207267 4930488E11Rik RIKEN cDNA 4930488E11 gene 2.55 NM_029062 4930521A18Rik RIKEN cDNA 4930521A18 gene 2.63 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 3.86 NM_027631 4931407G18Rik RIKEN cDNA 4931407G18 gene 2.13 NM_025744 4933404M02Rik RIKEN cDNA 4933404M02 gene 2.50 NM_177828 4933429F08Rik RIKEN cDNA 4933429F08 gene 2.26 NM_177314 5330439B14Rik RIKEN cDNA 5330439B14 gene 2.59 NM_146091 5730596K20Rik RIKEN cDNA 5730596K20 gene 2.54 NM_001033383 6430526N21Rik RIKEN cDNA 6430526N21 gene 2.99 NM_172930 6430550H21Rik RIKEN cDNA 6430550H21 gene 2.99 NM_001039720 9030619P08Rik RIKEN cDNA 9030619P08 gene 2.87 NM_176849 9430010O03Rik RIKEN cDNA 9430010O03 gene 2.65 NM_015770 a Nonagouti 2.69 NM_177668 A030001H23Rik RIKEN cDNA A030001H23 gene 2.27 NM_177194 A130023I24Rik RIKEN cDNA A130023I24 gene 2.40 NM_175687 A230050P20Rik RIKEN cDNA A230050P20 gene 2.22 NM_177334 A230074B11Rik RIKEN cDNA A230074B11 gene 2.15 NM_172447 A330021E22Rik RIKEN cDNA A330021E22 gene 2.21 NM_001031621 Abca17 ATP-binding cassette, sub-family A (ABC1), member 17 2.69 NM_007378 Abca4 ATP-binding cassette, sub-family A (ABC1), member 4 3.37 NM_001033163 Abhd9 Abhydrolase domain containing 9 2.13 NM_009598 Ace Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 2.57 NM_080633 Aco2 Aconitase 2, mitochondrial 2.17 NM_013455 Acr Preproacrosin 2.53 NM_053178 Acsbg1 Acyl-CoA synthetase bubblegum family member 1 2.29 NM_016870 Acsm3 Acyl-CoA synthetase medium-chain family member 3 2.19 NM_007394 Acvr1 Activin A receptor, type 1 2.13 NM_153397 Adam32 A disintegrin and metallopeptidase domain 32 2.17 NM_007402 Adam7 A disintegrin and metallopeptidase domain 7 2.58 NM_178873 Adck2 AarF domain containing kinase 2 2.48 NM_009626 Adh7 Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 3.03 NM_178803 Aebp2 AE binding protein 2 2.17 NM_027373 Afap1 Actin filament associated protein 1 2.11 NM_174849 Agbl5 ATP/GTP binding protein-like 5 2.47 NM_001033476 Ahnak2 AHNAK nucleoprotein 2 2.33 NM_013465 Ahsg Alpha-2-HS-glycoprotein 2.46 NM_134044 AI413782 Expressed sequence AI413782 2.74 NM_173016 AI427515 Expressed sequence AI427515 2.41 NM_001033199 AI747448 Expressed sequence AI747448 2.11 NM_007432 Akp3 3, intestine, not Mn requiring 2.45 NM_013467 Aldh1a1 Aldehyde dehydrogenase family 1, subfamily A1 3.12 NM_172532 Aldh5a1 Aldhehyde dehydrogenase family 5, subfamily A1 2.52 NM_144903 Aldob Aldolase 2, B isoform 2.73 NM_183142 Alg11 Asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase) 2.25 NM_026303 Alkbh8 AlkB, alkylation repair homolog 8 (E. coli) 2.15 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 2.42

92 NM_172935 Amdhd2 Amidohydrolase domain containing 2 2.19 NM_153319 Amot Angiomotin 2.41 NM_028779 Ampd2 Adenosine monophosphate deaminase 2 (isoform L) 2.12 NM_007449 Ang2 Angiogenin, ribonuclease A family, member 2 2.34 NM_178655 Ank2 Ankyrin 2, brain 2.17 NM_029245 Ankrd53 Ankyrin repeat domain 53 2.25 NM_010730 Anxa1 2.34 NM_013470 Anxa3 Annexin A3 2.69 NM_172262 Aof1 Amine oxidase, flavin containing 1 2.50 NM_009677 Ap1g1 Adaptor protein complex AP-1, gamma 1 subunit 2.16 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 3.72 NM_182994 Arl5a ADP-ribosylation factor-like 5A 2.11 NM_019717 Arl6ip2 ADP-ribosylation factor-like 6 interacting protein 2 2.27 NM_145429 Arrb2 Arrestin, beta 2 2.38 NM_025972 Asahl N-acylsphingosine amidohydrolase (acid ceramidase)-like 2.18 NM_080467 Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 2.17 NM_015732 Axin2 Axin2 2.19 NM_194347 AY358078 CDNA sequence AY358078 2.19 NM_080640 Baalc Brain and acute leukemia, cytoplasmic 2.56 NM_013863 Bag3 Bcl2-associated athanogene 3 2.29 NM_026121 Bag4 BCL2-associated athanogene 4 2.32 NM_027088 Bap1 Brca1 associated protein 1 2.16 NM_178446 BC013481 CDNA sequence BC013481 3.19 NM_145590 BC017158 CDNA sequence BC017158 2.28 NM_145430 BC017647 CDNA sequence BC017647 2.42 NM_146215 BC025546 CDNA sequence BC025546 2.30 NM_146082 BC027072 CDNA sequence BC027072 2.14 NM_172293 BC038822 CDNA sequence BC038822 2.33 NM_198301 BC052328 CDNA sequence BC052328 2.20 NM_145635 BC054059 CDNA sequence BC054059 2.13 NM_177572 BC057371 CDNA sequence BC057371 2.23 NM_001033001 BC065397 CDNA sequence BC065397 2.88 NM_013867 Bcar3 Breast cancer anti-estrogen resistance 3 2.26 NM_198161 Bhlhb9 Basic helix-loop-helix domain containing, class B9 2.47 NM_009756 Bmp10 Bone morphogenetic protein 10 2.69 NM_080708 Bmp2k BMP2 inducible kinase 2.13 NM_030178 Brpf1 Bromodomain and PHD finger containing, 1 3.00 NM_138678 Butr1 Butyrophilin related 1 2.58 NM_181323 C130090K23Rik RIKEN cDNA C130090K23 gene 2.25 NM_207233 C1ql2 Complement component 1, q subcomponent-like 2 2.60 NM_023143 C1r Complement component 1, r subcomponent 2.29 NM_001039231 C230055K05Rik RIKEN cDNA C230055K05 gene 2.14 NM_009778 C3 Complement component 3 2.12 NM_198663 C87499 Expressed sequence C87499 2.86 NM_133766 C920006C10Rik RIKEN cDNA C920006C10 gene 2.32 NM_007583 Cacng2 Calcium channel, voltage-dependent, gamma subunit 2 2.26 NM_028296 Car10 Carbonic anhydrase 10 3.02 NM_009809 Casp14 Caspase 14 2.13 NM_007617 Cav3 Caveolin 3 2.36 NM_172633 Cbln2 Cerebellin 2 precursor protein 2.41 NM_001033654 Ccdc139 Coiled-coil domain containing 139 3.09 NM_029212 Ccdc33 Coiled-coil domain containing 33 2.22 NM_026070 Ccdc53 Coiled-coil domain containing 53 2.24 NM_026459 Ccdc70 Coiled-coil domain containing 70 2.23 NM_201372 Ccdc84 Coiled-coil domain containing 84 2.73 NM_172405 Ccdc98 Coiled-coil domain containing 98 2.11 NM_011333 Ccl2 Chemokine (C-C motif) ligand 2 2.49 NM_001013412 Ccl26l Chemokine (C-C motif) ligand 26-like 2.42

93 NM_013652 Ccl4 Chemokine (C-C motif) ligand 4 2.30 NM_007639 Cd1d1 CD1d1 antigen 2.64 NM_144943 Cd207 CD 207 antigen 2.16 NM_009690 Cd5l CD5 antigen-like 2.27 NM_138309 Cd99l2 Cd99 antigen-like 2 2.14 NM_027276 Cdc16 CDC16 cell division cycle 16 homolog (S. cerevisiae) 2.25 NM_198164 Cdc2l6 Cell division cycle 2-like 6 (CDK8-like) 2.29 NM_007671 Cdkn2c Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.60 NM_175565 Cdv3 Carnitine deficiency-associated gene expressed in ventricle 3 2.19 NM_175565 Cdv3 Carnitine deficiency-associated gene expressed in ventricle 3 2.19 NM_001037136 Centg2 Centaurin, gamma 2 2.76 NM_015780 Cfhr1 Complement factor H-related 1 2.42 NM_145979 Chd4 Chromodomain helicase DNA binding protein 4 2.41 NM_018818 Chm Choroidermia 2.12 NM_029633 Clasp2 CLIP associating protein 2 2.27 NM_178697 Clca5 Chloride channel calcium activated 5 2.55 NM_023878 Cldn10 Claudin 10 2.22 NM_027218 Clec4b1 C-type lectin domain family 4, member b1 2.37 NM_001039162 Clip2 CAP-GLY domain containing linker protein 2 2.42 NM_013748 Clnk Cytokine-dependent hematopoietic cell linker 2.41 NM_175554 Clspn Claspin homolog (Xenopus laevis) 2.13 NM_016877 Cnot4 CCR4-NOT transcription complex, subunit 4 2.54 NM_008779 Cntn3 Contactin 3 2.46 NM_029838 Col25a1 Procollagen, type XXV, alpha 1 2.16 NM_172687 Coq3 Coenzyme Q3 homolog, methyltransferase (yeast) 2.47 NM_007748 Cox6a1 Cytochrome c oxidase, subunit VI a, polypeptide 1 2.28 NM_030052 Cox7b2 Cytochrome c oxidase subunit VIIb2 2.17 NM_001024698 Cpa2 , pancreatic 2.21 NM_001033471 Cpxcr1 CPX chromosome region, candidate 1 2.25 NM_028798 Crct1 Cysteine-rich C-terminal 1 2.81 NM_009639 Crisp3 Cysteine-rich secretory protein 3 2.18 NM_013808 Csrp3 Cysteine and glycine-rich protein 3 2.35 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase NM_212450 Ctdspl2 like 2 2.12 NM_028288 Cul4b Cullin 4B 3.81 NM_026307 Cuta CutA divalent cation tolerance homolog (E. coli) 2.50 NM_009140 Cxcl2 Chemokine (C-X-C motif) ligand 2 2.44 NM_007807 Cybb Cytochrome b-245, beta polypeptide 2.43 NM_145474 Cyp2d34 Cytochrome P450, family 2, subfamily d, polypeptide 34 2.18 NM_177382 Cyp2r1 Cytochrome P450, family 2, subfamily r, polypeptide 1 2.15 NM_177307 Cyp4f39 Cytochrome P450, family 4, subfamily f, polypeptide 39 3.23 NM_001037999 Dbi Diazepam binding inhibitor 2.25 NM_027030 Dcps Decapping enzyme, scavenger 2.27 NM_007916 Ddx19a DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a 2.32 NM_010029 Ddx4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 4.49 NM_028074 Ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 2.29 NM_026360 Ddx47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.18 NM_027156 Ddx51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.39 NM_007843 Defb1 Defensin beta 1 2.68 NM_013756 Defb3 Defensin beta 3 2.23 NM_001034910 Defb42 Defensin beta 42 2.25 NM_030734 Defb5 Defensin beta 5 2.48 NM_153108 Defb8 Defensin beta 8 2.19 NM_001025296 Dffa DNA fragmentation factor, alpha subunit 2.79 NM_177914 Dgkk Diacylglycerol kinase kappa 2.68 NM_175512 Dhrs9 Dehydrogenase/reductase (SDR family) member 9 2.26 NM_007839 Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 2.81 NM_144831 Dhx8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.15 NM_177360 Dmrt3 Doublesex and mab-3 related transcription factor 3 2.48

94 NM_010058 Dmwd Dystrophia myotonica-containing WD repeat motif 2.33 NM_198412 Dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 2.44 NM_001025947 Dnm1l 1-like 2.88 NM_010071 Dok2 Docking protein 2 2.23 NM_013504 Dsc1 Desmocollin 1 3.30 NM_001013826 Dupd1 Dual specificity phosphatase and pro isomerase domain containing 1 2.15 NM_007888 Dvl2 Dishevelled 2, dsh homolog (Drosophila) 2.63 NM_028258 Dzip1l DAZ interacting protein 1-like 2.26 NM_176957 E030049G20Rik RIKEN cDNA E030049G20 gene 3.05 NM_001039556 E130016E03Rik RIKEN cDNA E130016E03 gene 2.46 NM_001013368 E2f8 E2F transcription factor 8 2.28 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 2.50 NM_134111 Eaf2 ELL associated factor 2 2.68 NM_010100 Edar Ectodysplasin-A receptor 2.14 NM_010104 Edn1 Endothelin 1 2.23 NM_010332 Ednra Endothelin receptor type A 2.34 NM_172504 EG212225 Predicted gene, EG212225 2.25 NM_177764 EG269902 Predicted gene, EG269902 2.14 NM_177849 EG329541 Predicted gene, EG329541 2.91 NM_001024673 EG330496 Predicted gene, EG330496 2.25 NM_001033540 EG330503 Predicted gene, EG330503 3.47 NM_198633 EG331392 Predicted gene, EG331392 2.23 NM_001034881 EG432870 Predicted gene, EG432870 2.69 NM_023737 Ehhadh Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 2.41 NM_010135 Enah Enabled homolog (Drosophila) 2.46 NM_001025388 Eno1 Enolase 1, alpha non-neuron 3.87 NM_010141 Epha7 Eph receptor A7 2.64 NM_007960 Etv1 Ets variant gene 1 2.47 NM_177788 Exoc3l Exocyst complex component 3-like 2.17 NM_007983 Faf1 Fas-associated factor 1 2.12 NM_027123 Fastkd3 FAST kinase domains 3 2.16 NM_175530 Fbxo46 F-box protein 46 2.72 NM_010212 Fhl2 Four and a half LIM domains 2 3.07 NM_010219 Fkbp4 FK506 binding protein 4 2.20 NM_019873 Fkbpl FK506 binding protein-like 2.24 NM_029798 Flywch2 FLYWCH family member 2 2.13 NM_144878 Fmo4 Flavin containing monooxygenase 4 2.31 NM_008031 Fmr1 Fragile X mental retardation syndrome 1 homolog 2.13 NM_027402 Fndc5 Fibronectin type III domain containing 5 2.16 NM_053202 Foxp1 Forkhead box P1 2.33 NM_026286 Ftmt Ferritin mitochondrial 2.27 NM_019468 G6pd2 Glucose-6-phosphate dehydrogenase 2 2.89 NM_008066 Gabra2 Gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 2.18 NM_178028 Galp Galanin-like peptide precursor 2.23 NM_028407 Gcap14 Granule cell antiserum positive 14 2.20 NM_133219 Gcnt2 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme 2.29 NM_027819 Ggt6 Gamma-glutamyltransferase 6 2.54 NM_144786 Ggtl3 Gamma-glutamyltransferase-like 3 2.24 NM_008121 Gja5 Gap junction membrane channel protein alpha 5 2.41 NM_008123 Gja8 Gap junction membrane channel protein alpha 8 3.46 NM_001033477 Gm1322 Gene model 1322, (NCBI) 2.62 NM_001033280 Gm94 Gene model 94, (NCBI) 2.15 NM_008141 Gnat2 Guanine nucleotide binding protein, alpha transducing 2 2.48 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide NM_010314 Gngt1 1 2.89 NM_001035122 Golm1 Golgi membrane protein 1 2.43 NM_016810 Gosr1 Golgi SNAP receptor complex member 1 2.48 NM_133776 Gpr110 G protein-coupled receptor 110 2.43 NM_010343 Gpx5 Glutathione peroxidase 5 2.21

95 NM_153528 Gramd1c GRAM domain containing 1C 2.24 NM_008171 Grin2b Glutamate receptor, ionotropic, NMDA2B (epsilon 2) 2.36 NM_008172 Grin2d Glutamate receptor, ionotropic, NMDA2D (epsilon 4) 2.57 NM_008174 Grm8 Glutamate receptor, metabotropic 8 2.58 NM_008181 Gsta1 Glutathione S-transferase, alpha 1 (Ya) 2.21 NM_008181 Gsta1 Glutathione S-transferase, alpha 1 (Ya) 2.21 NM_026764 Gstm4 Glutathione S-transferase, mu 4 2.35 NM_010360 Gstm5 Glutathione S-transferase, mu 5 2.77 NM_008178 Gsx1 GS homeobox 1 3.94 NM_133256 Gsx2 GS homeobox 2 2.43 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 2.16 NM_010364 Gtf2h4 General transcription factor II H, polypeptide 4 2.15 NM_145067 Gucy2c Guanylate cyclase 2c 2.48 NM_010293 Gykl1 Glycerol kinase-like 1 2.82 NM_010381 H2-Ea Histocompatibility 2, class II antigen E alpha 2.22 NM_010402 Hand2 and derivatives expressed transcript 2 2.42 NM_011827 Hcst Hematopoietic cell signal transducer 2.12 NM_144835 Heatr1 HEAT repeat containing 1 2.41 NM_177171 Heatr5a HEAT repeat containing 5A 3.88 Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 NM_010418 Herc2 (CHC1)-like domain (RLD) 2 2.26 NM_010432 Hipk1 Homeodomain interacting protein kinase 1 2.58 NM_172746 Hirip3 HIRA interacting protein 3 2.44 NM_023422 Hist1h2bc Histone cluster 1, H2bc 2.82 NM_008252 Hmgb2 High mobility group box 2 2.71 NM_008295 Hsd3b5 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 3.00 NM_010483 Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 2.31 NM_028957 Hyal5 Hyaluronoglucosaminidase 5 2.30 NM_026601 Hyi Hydroxypyruvate isomerase homolog (E. coli) 2.56 NM_010491 Iapp Islet amyloid polypeptide 2.39 NM_198653 Iars2 -tRNA synthetase 2, mitochondrial 3.10 NM_011940 Ifi202b Interferon activated gene 202B 2.89 NM_183029 Igf2bp2 Insulin-like growth factor 2 mRNA binding protein 2 2.46 NM_008343 Igfbp3 Insulin-like growth factor binding protein 3 2.31 NM_010548 Il10 Interleukin 10 2.68 NM_008354 Il12rb2 receptor, beta 2 2.26 NM_010555 Il1r2 Interleukin 1 receptor, type II 2.28 NM_008366 Il2 Interleukin 2 2.89 NM_013563 Il2rg Interleukin 2 receptor, gamma chain 4.24 NM_010556 Il3 Interleukin 3 3.14 NM_133775 Il33 2.44 NM_008370 Il5ra Interleukin 5 receptor, alpha 4.09 NM_027927 Ints12 Integrator complex subunit 12 2.44 NM_178632 Ints7 Integrator complex subunit 7 2.86 NM_153414 Ints9 Integrator complex subunit 9 2.15 NM_001001309 Itga8 Integrin alpha 8 2.70 NM_011365 Itsn2 Intersectin 2 2.36 NM_025734 Kcng4 Potassium voltage-gated channel, subfamily G, member 4 2.22 NM_172805 Kcnh5 Potassium voltage-gated channel, subfamily H (eag-related), member 5 5.27 NM_001031811 Kcnh8 Potassium voltage-gated channel, subfamily H (eag-related), member 8 2.17 NM_001031811 Kcnh8 Potassium voltage-gated channel, subfamily H (eag-related), member 8 2.17 NM_019659 Kcnj1 Potassium inwardly-rectifying channel, subfamily J, member 1 2.54 NM_008432 Kcnu1 Potassium channel, subfamily U, member 1 2.15 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 4.54 NM_010629 Kifap3 Kinesin-associated protein 3 4.02 NM_010648 Klra3 Killer cell lectin-like receptor, subfamily A, member 3 2.14 NM_008526 Klrb1d Killer cell lectin-like receptor subfamily B member 1D 5.09 NM_010659 Krt31 Keratin 31 2.28 NM_010665 Krt32 Keratin 32 2.36

96 NM_001039666 Krt40 Keratin 40 2.29 NM_130857 Krtap16-5 Keratin associated protein 16-5 2.14 NM_001033131 Krtdap Keratinocyte differentiation associated protein 2.32 NM_027552 Kynu (L- hydrolase) 2.14 NM_025984 Lce1a1 Late cornified envelope 1A1 2.36 NM_010695 Lcn4 Lipocalin 4 2.56 NM_146146 Lepr 2.35 Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), NM_011095 Lilrb3 member 3 2.41 NM_001001980 Limch1 LIM and calponin homology domains 1 2.14 NM_001037918 Lipt1 Lipoyltransferase 1 2.98 NM_026719 Lmbrd1 LMBR1 domain containing 1 3.21 NM_177178 Lmbrd2 LMBR1 domain containing 2 2.54 NM_019390 Lmna Lamin A 2.31 NM_207222 Lmo3 LIM domain only 3 2.38 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 2.79 NM_022882 Lpin2 Lipin 2 2.42 NM_001033439 Lrch1 Leucine-rich repeats and calponin homology (CH) domain containing 1 2.65 NM_175124 Lrrc28 Leucine rich repeat containing 28 2.91 NM_029985 Lrrc42 Leucine rich repeat containing 42 2.12 NM_178725 Lrrc4c Leucine rich repeat containing 4C 2.82 NM_146006 Lss Lanosterol synthase 2.12 NM_024452 Luzp1 Leucine zipper protein 1 2.12 NM_133688 Lyrm5 LYR motif containing 5 2.14 NM_017372 Lyzs Lysozyme 2.20 NM_011839 Mab21l2 Mab-21-like 2 (C. elegans) 2.70 NM_175296 Mael Maelstrom homolog (Drosophila) 2.18 NM_026859 Maf1 MAF1 homolog (S. cerevisiae) 3.09 NM_020280 Magea4 Melanoma antigen, family A, 4 2.74 NM_001038609 Mapt -associated protein tau 2.26 NM_010771 Matr3 Matrin 3 2.30 NM_134012 Mbtd1 Mbt domain containing 1 2.36 NM_008563 Mcm3 Minichromosome maintenance deficient 3 (S. cerevisiae) 2.51 NM_010782 Mcpt9 Mast cell protease 9 3.56 NM_144933 Med17 Mediator complex subunit 17 2.35 NM_144913 Mepce Methylphosphate capping enzyme 5.02 NM_001039214 Mex3c Mex3 homolog C (C. elegans) 2.82 NM_010796 Mgl1 Macrophage galactose N-acetyl-galactosamine specific lectin 1 2.18 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 2.34 NM_011845 Mid2 Midline 2 2.71 NM_025910 Mina Myc induced nuclear antigen 2.49 NM_011746 Mkrn3 Makorin, ring finger protein, 3 2.35 NM_029931 Mllt3 Myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) 2.16 NM_080453 Mmp28 Matrix metallopeptidase 28 (epilysin) 2.22 NM_013826 Mocs2 Molybdenum cofactor synthesis 2 2.65 NM_177448 Mogat2 Monoacylglycerol O-acyltransferase 2 2.14 NM_153395 Mon2 MON2 homolog (yeast) 2.19 NM_198162 Morc2a Microrchidia 2A 2.17 NM_008619 Mov10 Moloney leukemia virus 10 2.20 NM_001034868 Mrgprx2 MAS-related GPR, member X2 2.57 NM_030116 Mrpl9 Mitochondrial ribosomal protein L9 2.14 NM_013601 Msx2 Homeo box, msh-like 2 2.47 NM_134092 Mtbp Mdm2, transformed 3T3 cell double minute binding protein 2.16 NM_013827 Mtf2 Metal response element binding transcription factor 2 2.13 NM_027134 Mtfmt Mitochondrial methionyl-tRNA formyltransferase 3.03 NM_028860 Mtmr3 Myotubularin related protein 3 2.65 NM_021503 Myoz2 Myozenin 2 2.28 NM_013792 Naglu Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) 2.44 NM_153126 Nat10 N-acetyltransferase 10 2.17

97 NM_010874 Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.78 NM_023172 Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 3.59 NM_025424 Nenf Neuron derived neurotrophic factor 2.41 NM_016720 Neu3 Neuraminidase 3 2.15 NM_010901 Nfatc3 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.33 NM_183248 Nkx6-2 NK6 transcription factor related, locus 2 (Drosophila) 2.40 NM_194058 Nlrp9b NLR family, pyrin domain containing 9B 2.44 NM_181547 Nostrin synthase trafficker 2.86 NM_008714 Notch1 Notch gene homolog 1 (Drosophila) 2.20 NM_133192 Npffr2 Neuropeptide FF receptor 2 2.43 NM_008706 Nqo1 NAD(P)H dehydrogenase, quinone 1 2.26 NM_009108 Nr1h4 Nuclear receptor subfamily 1, group H, member 4 2.97 NM_134122 Nrm Nurim (nuclear envelope membrane protein) 2.55 NM_026330 Nsmce1 Non-SMC element 1 homolog (S. cerevisiae) 2.18 NM_026746 Nsmce2 Non-SMC element 2 homolog (MMS21, S. cerevisiae) 2.49 NM_026004 Nt5c3 5'-nucleotidase, cytosolic III 2.20 NM_027722 Nudt4 Nudix (nucleoside diphosphate linked moiety X)-type motif 4 2.21 NM_175749 Nup153 Nucleoporin 153 2.67 NM_001002929 Nup85 Nucleoporin 85 2.46 NM_153092 Nupl2 Nucleoporin like 2 2.43 NM_030250 Nus1 Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.20 NM_177767 Ogfod1 2-oxoglutarate and iron-dependent domain containing 1 2.26 NM_146921 Olfr1 Olfactory receptor 1 2.56 NM_207564 Olfr1083 Olfactory receptor 1083 2.29 NM_146835 Olfr109 Olfactory receptor 109 3.76 NM_146661 Olfr1112 Olfactory receptor 1112 2.29 NM_001011836 Olfr1129 Olfactory receptor 1129 2.37 NM_146320 Olfr1145 Olfactory receptor 1145 2.28 NM_001011517 Olfr1193 Olfactory receptor 1193 2.13 NM_146753 Olfr1195 Olfactory receptor 1195 2.25 NM_146897 Olfr1214 Olfactory receptor 1214 2.40 NM_146459 Olfr1215 Olfactory receptor 1215 2.47 NM_146476 Olfr1254 Olfactory receptor 1254 2.14 NM_146794 Olfr1263 Olfactory receptor 1263 2.27 NM_146908 Olfr1280 Olfactory receptor 1280 2.17 NM_146404 Olfr1289 Olfactory receptor 1289 4.97 NM_146403 Olfr1295 Olfactory receptor 1295 2.93 NM_207151 Olfr1308 Olfactory receptor 1308 2.13 NM_146362 Olfr1312 Olfactory receptor 1312 2.15 NM_146332 Olfr135 Olfactory receptor 135 2.21 NM_147003 Olfr139 Olfactory receptor 139 2.49 NM_001011775 Olfr1419 Olfactory receptor 1419 2.20 NM_146678 Olfr1428 Olfactory receptor 1428 2.41 NM_146989 Olfr1496 Olfactory receptor 1496 2.25 NM_146432 Olfr1512 Olfactory receptor 1512 2.28 NM_019476 Olfr159 Olfactory receptor 159 2.15 NM_147001 Olfr172 Olfactory receptor 172 2.40 NM_147000 Olfr173 Olfactory receptor 173 2.34 NM_001001809 Olfr218 Olfactory receptor 218 2.11 NM_001011778 Olfr257 Olfactory receptor 257 2.37 NM_146457 Olfr282 Olfactory receptor 282 2.15 NM_147036 Olfr283 Olfactory receptor 283 2.52 NM_212436 Olfr301 Olfactory receptor 301 2.12 NM_001011819 Olfr312 Olfactory receptor 312 2.90 NM_146938 Olfr346 Olfactory receptor 346 2.46 NM_146627 Olfr350 Olfactory receptor 350 2.28 NM_146940 Olfr352 Olfactory receptor 352 2.11 NM_146347 Olfr390 Olfactory receptor 390 2.28

98 NM_001011863 Olfr406 Olfactory receptor 406 2.87 NM_001011528 Olfr456 Olfactory receptor 456 2.13 NM_001005488 Olfr467 Olfactory receptor 467 2.29 NM_146583 Olfr52 Olfactory receptor 52 2.59 NM_146361 Olfr557 Olfactory receptor 557 2.42 NM_147092 Olfr561 Olfactory receptor 561 2.20 NM_001001805 Olfr576 Olfactory receptor 576 3.63 NM_147115 Olfr578 Olfactory receptor 578 3.26 NM_207556 Olfr592 Olfactory receptor 592 2.28 NM_147070 Olfr604 Olfactory receptor 604 2.21 NM_147081 Olfr610 Olfactory receptor 610 2.14 NM_147099 Olfr616 Olfactory receptor 616 2.22 NM_147119 Olfr632 Olfactory receptor 632 3.82 NM_146392 Olfr720 Olfactory receptor 720 2.49 NM_001011809 Olfr728 Olfactory receptor 728 2.26 NM_207558 Olfr750 Olfactory receptor 750 2.36 NM_146555 Olfr805 Olfactory receptor 805 2.15 NM_146562 Olfr862 Olfactory receptor 862 2.41 NM_146798 Olfr878 Olfactory receptor 878 2.26 NM_146336 Olfr893 Olfactory receptor 893 2.94 NM_146272 Olfr930 Olfactory receptor 930 2.55 NM_001011518 Olfr94 Olfactory receptor 94 2.61 NM_146510 Olfr98 Olfactory receptor 98 2.78 NM_146515 Olfr99 Olfactory receptor 99 2.16 NM_016967 Olig2 Oligodendrocyte transcription factor 2 2.31 NM_205822 Omt2b Oocyte maturation, beta 2.39 NM_198661 Oog2 Oogenesin 2 2.48 NM_027950 Osgin1 Oxidative stress induced growth inhibitor 1 2.78 NM_178933 Ostb Organic solute transporter beta 2.94 NM_001025244 OTTMUSG00000002177 Predicted gene, OTTMUSG00000002177 2.17 NM_177865 OTTMUSG00000008540 Predicted gene, OTTMUSG00000008540 2.84 NM_024188 Oxct1 3-oxoacid CoA transferase 1 2.45 NM_011026 P2rx4 Purinergic receptor P2X, ligand-gated 4 2.33 NM_021362 Pappa Pregnancy-associated plasma protein A 2.24 NM_016694 Park2 2.19 NM_177460 Parp16 Poly (ADP-ribose) polymerase family, member 16 2.15 NM_030253 Parp9 Poly (ADP-ribose) polymerase family, member 9 2.31 NM_130878 Pcdh21 Protocadherin 21 2.11 NM_053133 Pcdhb8 Protocadherin beta 8 2.48 NM_033582 Pcdhga12 Protocadherin gamma subfamily A, 12 2.45 NM_033583 Pcdhga12 Protocadherin gamma subfamily A, 12 3.02 NM_033586 Pcdhga12 Protocadherin gamma subfamily A, 12 2.24 NM_033587 Pcdhga12 Protocadherin gamma subfamily A, 12 2.16 NM_033589 Pcdhga12 Protocadherin gamma subfamily A, 12 2.11 NM_153565 Pcsk9 Proprotein convertase subtilisin/kexin type 9 2.44 NM_211138 Pcyt1b Phosphate cytidylyltransferase 1, choline, beta isoform 2.48 NM_201607 Pde4c Phosphodiesterase 4C, cAMP specific 2.23 NM_172263 Pde8b Phosphodiesterase 8B 2.62 NM_146156 Pdik1l PDLIM1 interacting kinase 1 like 3.11 NM_172665 Pdk1 Pyruvate dehydrogenase kinase, isoenzyme 1 2.13 NM_018858 Pebp1 Phosphatidylethanolamine binding protein 1 2.46 NM_011067 Per3 Period homolog 3 (Drosophila) 2.68 NM_144896 Pet112l PET112-like (yeast) 2.15 NM_145122 Pex16 Peroxisome biogenesis factor 16 2.26 NM_001013369 Pfdn4 Prefoldin 4 2.50 NM_029303 Pfn3 Profilin 3 2.43 NM_029404 Phf14 PHD finger protein 14 2.57 NM_029293 Phpt1 Phosphohistidine phosphatase 1 2.94

99 NM_172992 Phtf2 Putative homeodomain transcription factor 2 2.59 NM_029988 Pigh Phosphatidylinositol glycan anchor biosynthesis, class H 2.16 NM_011084 Pik3c2g Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide 2.17 NM_008841 Pik3r2 Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) 2.28 NM_008863 Pkib Protein kinase inhibitor beta, cAMP dependent, testis specific 2.42 NM_013631 Pklr liver and red blood cell 2.57 NM_011099 Pkm2 Pyruvate kinase, muscle 2.39 NM_001029838 Pknox2 Pbx/knotted 1 homeobox 2 2.27 NM_026163 Pkp2 Plakophilin 2 2.90 NM_201394 Plec1 1 2.59 NM_011123 Plp1 Proteolipid protein (myelin) 1 2.61 NM_173180 Pmpca Peptidase (mitochondrial processing) alpha 2.61 NM_172683 Pogz Pogo transposable element with ZNF domain 2.87 NM_008892 Pola1 Polymerase (DNA directed), alpha 1 2.43 NM_028370 Pot1b Protection of telomeres 1B 2.35 NM_008849 Pou1f1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) 3.20 NM_021529 Ppp2r3c Protein phosphatase 2, regulatory subunit B'', gamma 2.24 NM_031377 Pramel1 Preferentially expressed antigen in melanoma-like 1 2.12 NM_007548 Prdm1 PR domain containing 1, with ZNF domain 2.49 NM_011174 Prh1 Proline rich protein HaeIII subfamily 1 2.89 NM_031499 Prh1 Proline rich protein HaeIII subfamily 1 2.81 NM_182997 Prkab2 Protein kinase, AMP-activated, beta 2 non-catalytic subunit 2.59 NM_008854 Prkaca Protein kinase, cAMP dependent, catalytic, alpha 2.42 NM_153745 Prkag3 Protein kinase, AMP-activated, gamma 3 non-catatlytic subunit 2.64 NM_008858 Prkcm Protein kinase C, mu 2.19 NM_008926 Prkg2 Protein kinase, cGMP-dependent, type II 2.11 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 2.21 NM_181852 Prl2c5 Prolactin family 2, subfamily c, member 5 2.28 NM_011166 Prl6a1 Prolactin family 6, subfamily a, member 1 2.14 NM_008930 Prl7a1 Prolactin family 7, subfamily a, member 1 2.19 NM_011168 Prl7a2 Prolactin family 7, subfamily a, member 2 2.26 NM_011120 Prl7d1 Prolactin family 7, subfamily d, member 1 2.58 NM_013637 Prm1 Protamine 1 2.44 NM_133182 Prmt2 Protein arginine N-methyltransferase 2 2.81 NM_008937 Prox1 Prospero-related homeobox 1 2.79 NM_138659 Prpf8 Pre-mRNA processing factor 8 2.60 NM_029294 Prps1l1 Phosphoribosyl pyrophosphate synthetase 1-like 1 2.24 NM_028447 Prrc1 Proline-rich coiled-coil 1 2.86 NM_008941 Prss7 Protease, serine, 7 (enterokinase) 2.12 NM_133351 Prss8 Protease, serine, 8 (prostasin) 2.11 NM_028195 Pscd4 Pleckstrin homology, Sec7 and coiled/coil domains 4 2.18 NM_011966 Psma4 Proteasome (prosome, macropain) subunit, alpha type 4 2.89 NM_026545 Psmd8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.41 NM_011877 Ptpn21 Protein tyrosine phosphatase, non-receptor type 21 2.55 NM_029928 Ptprb Protein tyrosine phosphatase, receptor type, B 2.31 NM_181395 Pxdn Peroxidasin homolog (Drosophila) 3.80 NM_153559 Qsox2 Quiescin Q6 sulfhydryl oxidase 2 2.11 NM_001033172 Rab11fip2 RAB11 family interacting protein 2 (class I) 2.34 NM_198163 Rab35 RAB35, member RAS oncogene family 2.15 NM_009009 Rad21 RAD21 homolog (S. pombe) 2.51 NM_011235 Rad51l3 RAD51-like 3 (S. cerevisiae) 2.21 NM_175112 Rae1 RAE1 RNA export 1 homolog (S. pombe) 2.28 NM_013832 Rasal1 RAS protein activator like 1 (GAP1 like) 2.17 NM_011249 Rbl1 Retinoblastoma-like 1 (p107) 2.51 NM_011252 Rbmx RNA binding motif protein, X .12 NM_023697 Rdh14 Retinol dehydrogenase 14 (all-trans and 9-cis) 2.64 NM_011260 Reg3g Regenerating islet-derived 3 gamma 3.09 NM_009044 Rel Reticuloendotheliosis oncogene 2.26

100 NM_011261 Reln 2.33 NM_009062 Rgs4 Regulator of G-protein signaling 4 2.23 NM_024182 Riok3 RIO kinase 3 (yeast) 2.13 NM_025343 Rmnd1 Required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.90 NM_001011877 Rnase11 Ribonuclease, RNase A family, 11 (non-active) 2.12 NM_011882 Rnasel Ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) 2.13 NM_033604 Rnf111 Ring finger 111 3.15 NM_001038696 Rnpc3 RNA-binding region (RNP1, RRM) containing 3 2.17 NM_145852 Ropn1l Ropporin 1-like 2.13 NM_199201 RP23-331L12.8 CMRF-35-like molecule 3 2.66 NM_019642 Rpn2 Ribophorin II 2.64 NM_001013376 Rpp38 Ribonuclease P/MRP 38 subunit (human) 2.82 NM_001033865 Rps27a Ribosomal protein S27a 2.19 NM_178376 Rraga Ras-related GTP binding A 2.39 NM_017475 Rragc Ras-related GTP binding C 2.61 NM_172566 Rundc1 RUN domain containing 1 2.19 NM_016924 Rwdd2b RWD domain containing 2B 2.29 NM_199422 S100a7a S100 calcium binding protein A7A 2.22 NM_011315 Saa3 Serum amyloid A 3 2.13 NM_020483 Sap30bp SAP30 binding protein 2.53 NM_007644 Scarb2 Scavenger receptor class B, member 2 3.45 NM_013883 Scmh1 Sex comb on midleg homolog 1 2.27 NM_011887 Scn11a Sodium channel, voltage-gated, type XI, alpha 3.06 NM_153055 Sec63 SEC63-like (S. cerevisiae) 2.18 NM_001033296 Sel1l2 Sel-1 suppressor of lin-12-like 2 (C. elegans) 3.32 NM_011456 Serpinb9e Serine (or cysteine) peptidase inhibitor, clade B, member 9e 2.20 NM_018820 Sertad1 SERTA domain containing 1 2.50 NM_021372 Sertad2 SERTA domain containing 2 2.49 NM_013651 Sf3a2 Splicing factor 3a, subunit 2 2.12 NM_134091 Sgsm3 Small G protein signaling modulator 3 2.44 NM_012009 Sh2d1b1 SH2 domain protein 1B1 2.24 NM_013664 Sh3gl1 SH3-domain GRB2-like 1 2.48 NM_172937 Shprh SNF2 histone linker PHD RING helicase 2.30 NM_022432 Sirt2 Sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) 8.61 NM_011384 Six6 Sine oculis-related homeobox 6 homolog (Drosophila) 2.42 NM_029444 Six6os1 Six6 opposite strand transcript 1 2.24 NM_172892 Slc13a4 Solute carrier family 13 (sodium/sulfate symporters), member 4 2.31 NM_001004148 Slc13a5 Solute carrier family 13 (sodium-dependent citrate transporter), member 5 2.43 NM_011394 Slc20a2 Solute carrier family 20, member 2 2.20 NM_175034 Slc24a5 Solute carrier family 24, member 5 2.17 NM_146257 Slc29a4 Solute carrier family 29 (nucleoside transporters), member 4 3.04 NM_080854 Slc34a3 Solute carrier family 34 (sodium phosphate), member 3 3.03 NM_007515 Slc7a3 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.24 NM_177353 Slc9a7 Solute carrier family 9 (sodium/hydrogen exchanger), isoform 7 2.42 NM_011407 Slfn1 Schlafen 1 2.87 NM_029273 Slitrk5 SLIT and NTRK-like family, member 5 2.41 NM_019710 Smc1a Structural maintenance of chromosomes 1A 2.67 NM_008574 Smcp Sperm mitochondria-associated cysteine-rich protein 2.38 NM_134034 Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 2.92 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27 NM_207243 Smgc Submandibular gland protein C 2.27

101 NM_176996 Smo Smoothened homolog (Drosophila) 2.34 NM_013669 Snap91 Synaptosomal-associated protein 91 2.24 NM_172926 Snx14 Sorting nexin 14 2.17 NM_011444 Sox5 SRY-box containing gene 5 2.97 NM_028852 Spatc1 Spermatogenesis and centriole associated 1 2.24 NM_026457 Spert Spermatid associated 2.17 NM_178628 Spg3a Spastic paraplegia 3A homolog (human) 2.30 NM_172287 Spire2 Spire homolog 2 (Drosophila) 2.15 NM_182990 Ssrp1 Structure specific recognition protein 1 2.18 NM_009216 Sstr1 Somatostatin receptor 1 2.15 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide NM_011372 St6galnac3 alpha-2,6-sialyltransferase 3 2.23 NM_153091 St7l Suppression of tumorigenicity 7-like 2.21 NM_024270 Stard3nl STARD3 N-terminal like 2.24 NM_178749 Stk32a Serine/threonine kinase 32A 2.13 NM_011500 Strn Striatin, calmodulin binding protein 2.28 NM_009294 Stx4a Syntaxin 4A (placental) 2.14 NM_172440 Stxbp5l Syntaxin binding protein 5-like 2.68 NM_144552 Stxbp6 Syntaxin binding protein 6 (amisyn) 2.14 NM_172294 Sulf1 1 2.69 NM_016771 Sult1d1 Sulfotransferase family 1D, member 1 2.18 NM_022724 Suv39h2 Suppressor of variegation 3-9 homolog 2 (Drosophila) 2.22 NM_028052 Synpr Synaptoporin 4.23 NM_020614 Taf1b TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B 2.13 NM_207029 Tas2r129 Taste receptor, type 2, member 129 2.45 NM_032005 Tbx19 T-box 19 2.23 NM_026305 Tceb2 Transcription elongation factor B (SIII), polypeptide 2 3.51 NM_013688 Tcte1 T-complex-associated testis expressed 1 3.79 NM_011577 Tgfb1 Transforming growth factor, beta 1 2.36 NM_009367 Tgfb2 Transforming growth factor, beta 2 2.19 NM_054089 Tgs1 Trimethylguanosine synthase homolog (S. cerevisiae) 3.16 NM_178060 Thra Thyroid hormone receptor alpha 2.19 NM_013897 Timm8b Translocase of inner mitochondrial membrane 8 homolog b (yeast) 3.85 NM_205819 Tlr11 Toll-like receptor 11 2.16 NM_181540 Tm6sf2 Transmembrane 6 superfamily member 2 3.06 NM_027992 Tmem106b Transmembrane protein 106B 2.46 NM_172998 Tmem118 Transmembrane protein 118 3.37 NM_025889 Tmem134 Transmembrane protein 134 2.22 NM_146234 Tmem32 Transmembrane protein 32 2.11 NM_019432 Tmem37 Transmembrane protein 37 2.70 NM_177102 Tmem91 Transmembrane protein 91 3.42 NM_008764 Tnfrsf11b Tumor necrosis factor receptor superfamily, member 11b () 2.28 NM_177371 Tnfsf15 Tumor necrosis factor (ligand) superfamily, member 15 2.18 NM_009403 Tnfsf8 Tumor necrosis factor (ligand) superfamily, member 8 2.62 NM_138599 Tomm70a Translocase of outer mitochondrial membrane 70 homolog A (yeast) 2.51 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein 3.22 NM_175114 Trak1 Trafficking protein, kinesin binding 1 2.58 NM_001024206 Trappc1 Trafficking protein particle complex 1 2.78 NM_198297 Trat1 receptor associated transmembrane adaptor 1 2.61 NM_197987 Trim37 Tripartite motif protein 37 3.81 NM_001013616 Trim6 Tripartite motif protein 6 2.66 NM_001033429 Trim75 Tripartite motif-containing 75 2.37 NM_011640 Trp53 Transformation related protein 53 2.43 NM_032000 Trps1 Trichorhinophalangeal syndrome I (human) 2.27 NM_199033 Tsen2 TRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) 2.16 NM_207228 Tsga10 Testis specific 10 2.35 NM_011654 Tuba1b Tubulin, alpha 1B 2.46 NM_011655 Tubb5 Tubulin, beta 5 2.76 NM_172253 Twistnb TWIST neighbor 2.31

102 NM_025334 Txndc12 Thioredoxin domain containing 12 (endoplasmic reticulum) 2.13 NM_031202 Tyrp1 -related protein 1 2.17 NM_177823 Ubash3a Ubiquitin associated and SH3 domain containing, A 2.91 NM_019562 Uchl5 Ubiquitin carboxyl-terminal esterase L5 2.66 NM_011671 Ucp2 Uncoupling protein 2 (mitochondrial, proton carrier) 3.30 NM_026573 Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) 2.54 NM_011684 V1ra2 Vomeronasal 1 receptor, A2 2.33 NM_207548 V1rd22 Vomeronasal 1 receptor, D22 2.50 NM_134231 V1re12 Vomeronasal 1 receptor, E12 2.11 NM_134196 V1re7 Vomeronasal 1 receptor, E7 2.19 NM_145842 V1re9 Vomeronasal 1 receptor, E9 3.24 NM_134217 V1rh8 Vomeronasal 1 receptor, H8 3.61 NM_009493 V2r4 Vomeronasal 2, receptor, 4 2.30 NM_011701 Vim 2.96 NM_011702 Vip Vasoactive intestinal polypeptide 2.39 NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) 2.23 NM_030181 Vsig1 V-set and immunoglobulin domain containing 1 2.18 NM_172445 Wdr37 WD repeat domain 37 2.83 NM_181400 Wdr47 WD repeat domain 47 2.25 NM_146039 Wdr60 WD repeat domain 60 2.41 NM_026323 Wfdc2 WAP four-disulfide core domain 2 2.17 NM_028816 Xpo6 Exportin 6 2.16 NM_016875 Ybx2 Y box protein 2 2.17 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta NM_011739 Ywhaq polypeptide 2.18 NM_028325 Zcchc12 Zinc finger, CCHC domain containing 12 3.23 NM_030708 Zfhx4 Zinc finger homeodomain 4 3.14 NM_009549 Zfp185 Zinc finger protein 185 2.17 NM_017467 Zfp316 Zinc finger protein 316 5.49 NM_001013745 Zfp57 Zinc finger protein 57 3.10 NM_153194 Zfp740 Zinc finger protein 740 2.12 NM_133228 Zfp87 Zinc finger protein 87 2.12 NM_011763 Zfp9 Zinc finger protein 9 2.22 NM_177263 Zhx3 Zinc fingers and 3 2.49 NM_026107 Zkscan6 Zinc finger with KRAB and SCAN domains 6 2.56 NM_025594 Zmat2 Zinc finger, matrin type 2 2.13 NM_177086 Zmat4 Zinc finger, matrin type 4 2.37 NM_001002780 2.60 NM_001008702 2.36 NM_001013752 2.28 NM_001025613 2.14 NM_001033152 2.22 NM_001033777 2.14 NM_001033809 2.69 NM_001037169 2.48 NM_001037750 2.23 NM_019427 2.85 NM_025765 2.51 NM_026649 4.59 NM_133677 2.26 NM_133695 2.77 NM_146058 2.17 NM_146422 3.32 NM_153061 2.15 NM_153168 2.31 NM_172419 3.05 NM_172976 3.02 NM_175010 2.29 NM_177008 2.36

103 NM_177177 2.32 NM_177654 2.95 NM_177895 3.18 NM_178391 2.42 NM_183292 2.76 NM_199147 2.16 NM_207226 2.58

SUPPLEMENTAL TABLE S9: Genes Demonstrating Decreased Phospho-CREB Binding in the Social Defeat Model (p<0.001)

Accession Number Symbol Name Fold Change NM_017380 9-Sep Septin 9 0.25 NM_053102 15-Sep Selenoprotein 0.42 NM_026757 0610010K14Rik RIKEN cDNA 0610010K14 gene 0.30 NM_026686 0610011F06Rik RIKEN cDNA 0610011F06 gene 0.27 NM_001013414 0610025P10Rik RIKEN cDNA 0610025P10 gene 0.33 NM_026714 0610037D15Rik RIKEN cDNA 0610037D15 gene 0.32 NM_026306 0610038D11Rik RIKEN cDNA 0610038D11 gene 0.37 NM_025377 1110001A07Rik RIKEN cDNA 1110001A07 gene 0.45 NM_019772 1110004F10Rik RIKEN cDNA 1110004F10 gene 0.43 NM_025364 1110005A23Rik RIKEN cDNA 1110005A23 gene 0.33 NM_001033141 1110006O17Rik RIKEN cDNA 1110006O17 gene 0.33 NM_001014995 1110013L07Rik RIKEN cDNA 1110013L07 gene 0.37 NM_025370 1110018J18Rik RIKEN cDNA 1110018J18 gene 0.29 NM_026753 1110019N10Rik RIKEN cDNA 1110019N10 gene 0.34 NM_172401 1110057K04Rik RIKEN cDNA 1110057K04 gene 0.28 NM_025817 1200009O22Rik RIKEN cDNA 1200009O22 gene 0.44 NM_026886 1500001A10Rik RIKEN cDNA 1500001A10 gene 0.44 NM_024283 1500015O10Rik RIKEN cDNA 1500015O10 gene 0.36 NM_024172 1500019G21Rik RIKEN cDNA 1500019G21 gene 0.30 NM_029309 1700010A17Rik RIKEN cDNA 1700010A17 gene 0.45 NM_025956 1700011H14Rik RIKEN cDNA 1700011H14 gene 0.41 NM_029587 1700012A03Rik RIKEN cDNA 1700012A03 gene 0.29 NM_021437 1700123O20Rik RIKEN cDNA 1700123O20 gene 0.27 NM_172701 1810007P19Rik RIKEN cDNA 1810007P19 gene 0.30 NM_025463 1810009A15Rik RIKEN cDNA 1810009A15 gene 0.39 NM_026940 1810015A11Rik RIKEN cDNA 1810015A11 gene 0.35 NM_025464 1810021J13Rik RIKEN cDNA 1810021J13 gene 0.32 NM_178619 1810026J23Rik RIKEN cDNA 1810026J23 gene 0.35 NM_026325 1810059G22Rik RIKEN cDNA 1810059G22 gene 0.33 NM_027237 2010003K11Rik RIKEN cDNA 2010003K11 gene 0.42 NM_025912 2010011I20Rik RIKEN cDNA 2010011I20 gene 0.44 NM_025564 2010012C16Rik RIKEN cDNA 2010012C16 gene 0.38 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 0.42 NM_027250 2010305A19Rik RIKEN cDNA 2010305A19 gene 0.39 NM_025591 2010309E21Rik RIKEN cDNA 2010309E21 gene 0.42 NM_175153 2010321M09Rik RIKEN cDNA 2010321M09 gene 0.41 NM_197998 2210021J22Rik RIKEN cDNA 2210021J22 gene 0.36 NM_027977 2310001A20Rik RIKEN cDNA 2310001A20 gene 0.34 NM_181649 2310002B06Rik RIKEN cDNA 2310002B06 gene 0.41 NM_175107 2310022A10Rik RIKEN cDNA 2310022A10 gene 0.26 NM_197991 2310044H10Rik RIKEN cDNA 2310044H10 gene 0.43 NM_025542 2410001C21Rik RIKEN cDNA 2410001C21 gene 0.34 NM_153152 2410015M20Rik RIKEN cDNA 2410015M20 gene 0.41 NM_183088 2410018M08Rik RIKEN cDNA 2410018M08 gene 0.44 NM_028611 2410091C18Rik RIKEN cDNA 2410091C18 gene 0.40 NM_028129 2610020H08Rik RIKEN cDNA 2610020H08 gene 0.45 NM_146084 2610024E20Rik RIKEN cDNA 2610024E20 gene 0.38

104 NM_027420 2610034B18Rik RIKEN cDNA 2610034B18 gene 0.45 NM_026476 2610101N10Rik RIKEN cDNA 2610101N10 gene 0.38 NM_028476 2610110G12Rik RIKEN cDNA 2610110G12 gene 0.43 NM_170592 2610205E22Rik RIKEN cDNA 2610205E22 gene 0.43 NM_027434 2610304G08Rik RIKEN cDNA 2610304G08 gene 0.39 NM_025599 2610528E23Rik RIKEN cDNA 2610528E23 gene 0.45 NM_026528 2700060E02Rik RIKEN cDNA 2700060E02 gene 0.41 NM_026511 2810002N01Rik RIKEN cDNA 2810002N01 gene 0.41 NM_025479 2810021B07Rik RIKEN cDNA 2810021B07 gene 0.35 NM_173382 2810046L04Rik RIKEN cDNA 2810046L04 gene 0.43 NM_027279 2810422O20Rik RIKEN cDNA 2810422O20 gene 0.30 NM_025944 2810432L12Rik RIKEN cDNA 2810432L12 gene 0.44 NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene 0.40 NM_028377 2900006K08Rik RIKEN cDNA 2900006K08 gene 0.36 NM_026543 3010026O09Rik RIKEN cDNA 3010026O09 gene 0.36 NM_029623 3110002H16Rik RIKEN cDNA 3110002H16 gene 0.37 NM_175195 3110056O03Rik RIKEN cDNA 3110056O03 gene 0.41 NM_199145 3110062M04Rik RIKEN cDNA 3110062M04 gene 0.32 NM_028469 3110082I17Rik RIKEN cDNA 3110082I17 gene 0.41 NM_025699 3230401D17Rik RIKEN cDNA 3230401D17 gene 0.31 NM_172698 4732418C07Rik RIKEN cDNA 4732418C07 gene 0.39 NM_029021 4833422F24Rik RIKEN cDNA 4833422F24 gene 0.44 NM_207267 4930488E11Rik RIKEN cDNA 4930488E11 gene 0.38 NM_207527 4930504O13Rik RIKEN cDNA 4930504O13 gene 0.39 NM_198607 4930572J05Rik RIKEN cDNA 4930572J05 gene 0.41 NM_172741 4931406P16Rik RIKEN cDNA 4931406P16 gene 0.42 NM_028888 4931428F04Rik RIKEN cDNA 4931428F04 gene 0.35 NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene 0.39 NM_177230 4932413O14Rik RIKEN cDNA 4932413O14 gene 0.38 NM_178935 4932441K18Rik RIKEN cDNA 4932441K18 gene 0.45 NM_172901 4933405O20Rik RIKEN cDNA 4933405O20 gene 0.39 NM_025750 4933417A18Rik RIKEN cDNA 4933417A18 gene 0.42 NM_025753 4933425O20Rik RIKEN cDNA 4933425O20 gene 0.31 NM_177607 4933430I17Rik RIKEN cDNA 4933430I17 gene 0.41 NM_194335 4933440H19Rik RIKEN cDNA 4933440H19 gene 0.40 NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene 0.28 NM_175110 5730577I03Rik RIKEN cDNA 5730577I03 gene 0.42 NM_178243 5830403L16Rik RIKEN cDNA 5830403L16 gene 0.36 NM_175232 5830427D03Rik RIKEN cDNA 5830427D03 gene 0.45 NM_026377 6330577E15Rik RIKEN cDNA 6330577E15 gene 0.45 NM_175521 6430598A04Rik RIKEN cDNA 6430598A04 gene 0.44 NM_173405 6530401C20Rik RIKEN cDNA 6530401C20 gene 0.44 NM_177374 6720458F09Rik RIKEN cDNA 6720458F09 gene 0.42 NM_001033983 7420426K07Rik RIKEN cDNA 7420426K07 gene 0.37 NM_183224 7530404M11Rik RIKEN cDNA 7530404M11 gene 0.43 NM_028984 8430406I07Rik RIKEN cDNA 8430406I07 gene 0.32 NM_178875 8430426H19Rik RIKEN cDNA 8430426H19 gene 0.45 NM_027829 9030607L17Rik RIKEN cDNA 9030607L17 gene 0.43 NM_030218 9130017N09Rik RIKEN cDNA 9130017N09 gene 0.45 NM_029960 9230104L09Rik RIKEN cDNA 9230104L09 gene 0.35 NM_146105 9630058J23Rik RIKEN cDNA 9630058J23 gene 0.42 NM_172836 9930021J03Rik RIKEN cDNA 9930021J03 gene 0.27 NM_181048 A130010J15Rik RIKEN cDNA A130010J15 gene 0.45 NM_001009819 A3galt2 Alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase) 0.39 NM_175287 A430005L14Rik RIKEN cDNA A430005L14 gene 0.45 NM_173032 A630047E20Rik RIKEN cDNA A630047E20 gene 0.38 NM_175449 A630077B13Rik RIKEN cDNA A630077B13 gene 0.44 NM_177118 A830073O21Rik RIKEN cDNA A830073O21 gene 0.40

105 NM_001033472 A830080D01Rik RIKEN cDNA A830080D01 gene 0.32 NM_212473 A930008G19Rik RIKEN cDNA A930008G19 gene 0.24 NM_001013793 AA388235 Expressed sequence AA388235 0.45 NM_001024512 AA536717 Expressed sequence AA536717 0.45 NM_177213 Abca15 ATP-binding cassette, sub-family A (ABC1), member 15 0.39 NM_021022 Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.41 NM_011510 Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.39 NM_013854 Abcf1 ATP-binding cassette, sub-family F (GCN20), member 1 0.38 NM_021304 Abhd1 Abhydrolase domain containing 1 0.37 NM_029631 Abhd14b Abhydrolase domain containing 14b 0.39 NM_009594 Abl1 V-abl Abelson murine leukemia oncogene 1 0.23 NM_013924 Abt1 Activator of basal transcription 0.36 NM_133904 Acacb Acetyl-Coenzyme A carboxylase beta 0.32 NM_172678 Acad9 Acyl-Coenzyme A dehydrogenase family, member 9 0.41 NM_009338 Acat2 Acetyl-Coenzyme A acetyltransferase 2 0.39 NM_025988 Acbd4 Acyl-Coenzyme A binding domain containing 4 0.27 NM_080633 Aco2 Aconitase 2, mitochondrial 0.33 NM_007387 Acp2 Acid phosphatase 2, lysosomal 0.28 NM_207668 Acpp Acid phosphatase, prostate 0.40 NM_025271 Actl7b Actin-like 7b 0.43 NM_023735 Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.44 NM_029344 Acyp2 2, muscle type 0.34 NM_007403 Adam8 A disintegrin and metallopeptidase domain 8 0.44 NM_028121 Adpgk ADP-dependent 0.43 NM_027373 Afap1 Actin filament associated protein 1 0.32 NM_021604 Agrn Agrin 0.44 NM_016702 Agxt Alanine-glyoxylate aminotransferase 0.43 NM_145542 Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.40 NM_207219 AI314976 Expressed sequence AI314976 0.43 NM_145505 AI450540 Expressed sequence AI450540 0.45 NM_178926 AI662250 Expressed sequence AI662250 0.32 NM_007433 Akp5 Alkaline phosphatase 5 0.41 NM_010241 Aktip Thymoma viral proto-oncogene 1 interacting protein 0.38 NM_020559 Alas1 Aminolevulinic acid synthase 1 0.38 NM_172532 Aldh5a1 Aldhehyde dehydrogenase family 5, subfamily A1 0.37 NM_009657 Aldoc Aldolase 3, C isoform 0.43 NM_024178 Alg14 Asparagine-linked glycosylation 14 homolog (yeast) 0.45 NM_198027 Alkbh6 AlkB, alkylation repair homolog 6 (E. coli) 0.18 NM_053156 Allc Allantoicase 0.44 NM_009662 Alox5 Arachidonate 5- 0.40 NM_028717 Als2 Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) 0.41 NM_007444 Amd1 S-adenosylmethionine decarboxylase 1 0.42 NM_172935 Amdhd2 Amidohydrolase domain containing 2 0.37 NM_033603 Amn Amnionless 0.43 NM_026904 Anapc10 Anaphase promoting complex subunit 10 0.38 NM_020581 Angptl4 Angiopoietin-like 4 0.42 NM_145154 Angptl6 Angiopoietin-like 6 0.42 NM_170728 Ank3 Ankyrin 3, epithelial 0.40 NM_023472 Ankra2 Ankyrin repeat, family A (RFXANK-like), 2 0.44 NM_027480 Ankrd24 Ankyrin repeat domain 24 0.29 NM_023210 Anp32e Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.43 NM_029505 Ap3m2 Adaptor-related protein complex 3, mu 2 subunit 0.35 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 0.40 NM_175087 Aqp6 Aquaporin 6 0.42 NM_007477 Arf2 ADP-ribosylation factor 2 0.35 NM_027667 Arhgap19 Rho GTPase activating protein 19 0.30 NM_007486 Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.43 NM_027144 Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.42

106 NM_001033329 Arhgef9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.44 NM_001017362 Arid3c AT rich interactive domain 3C (BRIGHT-like) 0.39 NM_194262 Arid4b AT rich interactive domain 4B (Rbp1 like) 0.39 NM_026577 Arl13b ADP-ribosylation factor-like 13B 0.45 NM_022992 Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 0.39 NM_001007578 Armcx6 Armadillo repeat containing, X-linked 6 0.37 NM_177647 Armetl1 Arginine-rich, mutated in early stage tumors-like 1 0.39 NM_026552 Arpc4 Actin related protein 2/3 complex, subunit 4 0.41 NM_178408 Arrdc1 Arrestin domain containing 1 0.38 NM_029847 Arsk Arylsulfatase K 0.31 NM_033474 Arvcf Armadillo repeat gene deleted in velo-cardio-facial syndrome 0.36 NM_133346 Asb6 Ankyrin repeat and SOCS box-containing protein 6 0.44 NM_007493 Asgr2 Asialoglycoprotein receptor 2 0.35 NM_011791 Ash2l Ash2 (absent, small, or homeotic)-like (Drosophila) 0.30 NM_133768 Asl Argininosuccinate lyase 0.36 NM_009791 Aspm Asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.39 NM_025651 Aste1 Asteroid homolog 1 (Drosophila) 0.33 NM_146065 Atf7 Activating transcription factor 7 0.43 NM_177236 Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.28 NM_033617 Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B 0.45 NM_009729 Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C 0.42 NM_023179 Atp6v1g2 ATPase, H+ transporting, lysosomal V1 subunit G2 0.40 NM_001038999 Atp8a1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.44 NM_001033201 AU014645 Expressed sequence AU014645 0.42 NM_145425 AV249152 Expressed sequence AV249152 0.35 NM_027106 Avpi1 Arginine vasopressin-induced 1 0.42 NM_016847 Avpr1a Arginine vasopressin receptor 1A 0.39 NM_011924 Avpr1b Arginine vasopressin receptor 1B 0.26 NM_145930 AW549877 Expressed sequence AW549877 0.43 NM_001033532 AW554918 Expressed sequence AW554918 0.44 NM_177235 B230209C24Rik RIKEN cDNA B230209C24 gene 0.31 NM_009735 B2m Beta-2 microglobulin 0.39 NM_172124 B3gat2 Beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) 0.31 NM_001024560 B930037P14Rik RIKEN cDNA B930037P14 gene 0.32 NM_174991 Bai1 Brain-specific inhibitor 1 0.45 NM_016812 Banp Btg3 associated nuclear protein 0.40 NM_027088 Bap1 Brca1 associated protein 1 0.42 NM_144885 BC005624 CDNA sequence BC005624 0.41 NM_139065 BC013481 CDNA sequence BC013481 0.34 NM_177632 BC022623 CDNA sequence BC022623 0.45 NM_199149 BC024868 CDNA sequence BC024868 0.42 NM_146215 BC025546 CDNA sequence BC025546 0.38 NM_173738 BC027344 CDNA sequence BC027344 0.45 NM_153513 BC028528 CDNA sequence BC028528 0.36 NM_153557 BC029214 CDNA sequence BC029214 0.44 NM_001001181 BC031181 CDNA sequence BC031181 0.32 NM_145943 BC031781 CDNA sequence BC031781 0.40 NM_172758 BC031853 CDNA sequence BC031853 0.32 NM_153795 BC032204 CDNA sequence BC032204 0.40 NM_153161 BC037034 CDNA sequence BC037034 0.38 NM_172295 BC037703 CDNA sequence BC037703 0.44 NM_177878 BC038925 CDNA sequence BC038925 0.35 NM_183143 BC048679 CDNA sequence BC048679 0.35 NM_178776 BC049715 CDNA sequence BC049715 0.33 NM_001002008 BC049807 CDNA sequence BC049807 0.31 NM_183181 BC050777 CDNA sequence BC050777 0.36 NM_001001493 BC056474 CDNA sequence BC056474 0.38 NM_026602 Bcas2 Breast carcinoma amplified sequence 2 0.36

107 NM_025392 Bccip BRCA2 and CDKN1A interacting protein 0.40 NM_009739 Bckdk Branched chain ketoacid dehydrogenase kinase 0.34 NM_009742 Bcl2a1a B-cell leukemia/lymphoma 2 related protein A1a 0.26 NM_007534 Bcl2a1b B-cell leukemia/lymphoma 2 related protein A1b 0.25 NM_007536 Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.27 NM_009754 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.42 NM_009745 Bcl7b B-cell CLL/lymphoma 7B 0.30 NM_029933 Bcl9 B-cell CLL/lymphoma 9 0.25 NM_009748 Bet1 Blocked early in transport 1 homolog (S. cerevisiae) 0.30 NM_001039179 Bicd2 Bicaudal D homolog 2 (Drosophila) 0.36 NM_021328 Bin3 Bridging integrator 3 0.40 NM_008528 Blnk B-cell linker 0.32 NM_026975 Bola1 BolA-like 1 (E. coli) 0.43 NM_175103 Bola2 BolA-like 2 (E. coli) 0.38 NM_009764 Brca1 Breast cancer 1 0.40 NM_144541 Bre Brain and reproductive organ-expressed protein 0.45 NM_134155 Brms1 Breast cancer metastasis-suppressor 1 0.36 NM_133889 Bsdc1 BSD domain containing 1 0.39 NM_172618 Btbd9 BTB (POZ) domain containing 9 0.27 NM_025295 Btd 0.44 NM_007570 Btg2 B-cell translocation gene 2, anti-proliferative 0.27 NM_013482 Btk Bruton agammaglobulinemia tyrosine kinase 0.31 NM_001037758 Btrc Beta-transducin repeat containing protein 0.43 NM_009773 Bub1b Budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.36 NM_001008705 Bud31 BUD31 homolog (yeast) 0.27 NM_021426 C030019F02Rik RIKEN cDNA C030019F02 gene 0.42 NM_007572 C1qa Complement component 1, q subcomponent, alpha polypeptide 0.37 NM_026125 C1qdc2 C1q domain containing 2 0.43 NM_181344 C1rl Complement component 1, r subcomponent-like 0.41 NM_009780 C4b Complement component 4B (Childo blood group) 0.44 NM_175696 C530028O21Rik RIKEN cDNA C530028O21 gene 0.43 NM_177344 C730025P13Rik RIKEN cDNA C730025P13 gene 0.39 NM_176900 C730034F03Rik RIKEN cDNA C730034F03 gene 0.36 NM_011274 C80913 Expressed sequence C80913 0.35 NM_146170 C87436 Expressed sequence C87436 0.43 NM_009781 Cacna1c Calcium channel, voltage-dependent, L type, alpha 1C subunit 0.41 NM_145121 Cacnb1 Calcium channel, voltage-dependent, beta 1 subunit 0.44 NM_019430 Cacng3 Calcium channel, voltage-dependent, gamma subunit 3 0.37 NM_009788 Calb1 Calbindin-28K 0.32 NM_007586 Calb2 Calbindin 2 0.23 NM_054084 Calcb Calcitonin-related polypeptide, beta 0.45 NM_026192 Calcoco1 Calcium binding and coiled coil domain 1 0.39 NM_009795 Capns1 Calpain, small subunit 1 0.40 NM_139150 Carf Calcium response factor 0.25 NM_138660 Casc3 Cancer susceptibility candidate 3 0.44 NM_009806 Cask Calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.38 NM_023224 Cblc Casitas B-lineage lymphoma c 0.43 NM_145595 Cbr4 Carbonyl reductase 4 0.42 NM_146178 Ccdc106 Coiled-coil domain containing 106 0.39 NM_026964 Ccdc124 Coiled-coil domain containing 124 0.36 NM_172428 Ccdc134 Coiled-coil domain containing 134 0.38 NM_001033654 Ccdc139 Coiled-coil domain containing 139 0.33 NM_025884 Ccdc16 Coiled-coil domain containing 16 0.42 NM_028804 Ccdc3 Coiled-coil domain containing 3 0.30 NM_175430 Ccdc40 Coiled-coil domain containing 40 0.37 NM_026186 Ccdc49 Coiled-coil domain containing 49 0.42 NM_001012309 Ccdc55 Coiled-coil domain containing 55 0.33 NM_029256 Ccdc83 Coiled-coil domain containing 83 0.30

108 NM_181577 Ccdc85a Coiled-coil domain containing 85A 0.39 NM_198616 Ccdc85b Coiled-coil domain containing 85B 0.38 NM_023731 Ccdc86 Coiled-coil domain containing 86 0.26 NM_172297 Ccdc9 Coiled-coil domain containing 9 0.38 NM_028771 Ccdc97 Coiled-coil domain containing 97 0.25 NM_001002787 Ccin Calicin 0.43 NM_009827 Cckar Cholecystokinin A receptor 0.37 NM_007627 Cckbr Cholecystokinin B receptor 0.40 NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 0.43 NM_013653 Ccl5 Chemokine (C-C motif) ligand 5 0.43 NM_007635 Ccng2 Cyclin G2 0.45 NM_017367 Ccni Cyclin I 0.43 NM_028181 Ccpg1 Cell cycle progression 1 0.39 NM_053180 Ccrk Cell cycle related kinase 0.44 NM_009836 Cct3 Chaperonin subunit 3 (gamma) 0.38 NM_007639 Cd1d1 CD1d1 antigen 0.34 NM_145634 Cd300lf CD300 antigen like family member F 0.39 NM_001039150 Cd44 CD44 antigen 0.38 NM_010778 Cd46 CD46 antigen, complement regulatory protein 0.32 NM_009853 Cd68 CD68 antigen 0.38 NM_007656 Cd82 CD82 antigen 0.43 NM_007661 Cdc2l1 Cell division cycle 2-like 1 0.40 NM_026410 Cdca5 Cell division cycle associated 5 0.38 NM_001008420 Cdh12 Cadherin 12 0.43 NM_011800 Cdh20 Cadherin 20 0.41 NM_026373 Cdk2ap2 CDK2-associated protein 2 0.33 NM_007668 Cdk5 Cyclin-dependent kinase 5 0.31 NM_009874 Cdk7 Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) 0.36 NM_175565 Cdv3 Carnitine deficiency-associated gene expressed in ventricle 3 0.41 NM_175565 Cdv3 Carnitine deficiency-associated gene expressed in ventricle 3 0.41 NM_028236 Ceacam18 CEA-related cell adhesion molecule 1 0.42 NM_144815 Cecr5 Cat eye syndrome chromosome region, candidate 5 homolog (human) 0.45 NM_021886 Cenph Centromere protein H 0.39 NM_028131 Cenpn Centromere protein N 0.38 NM_207223 Centb5 Centaurin, beta 5 0.39 NM_001040112 Centd2 Centaurin, delta 2 0.43 NM_025475 Cep27 Centrosomal protein 27 0.42 NM_021456 Ces1 Carboxylesterase 1 0.42 NM_133960 Ces6 Carboxylesterase 6 0.45 NM_011801 Cfdp1 Craniofacial development protein 1 0.42 NM_009890 Ch25h 25-hydroxylase 0.41 NM_025336 Chchd3 Coiled-coil-helix-coiled-coil-helix domain containing 3 0.45 NM_025351 Chchd6 Coiled-coil-helix-coiled-coil-helix domain containing 6 0.38 NM_145979 Chd4 Chromodomain helicase DNA binding protein 4 0.45 NM_007691 Chek1 Checkpoint kinase 1 homolog (S. pombe) 0.36 NM_016681 Chek2 CHK2 checkpoint homolog (S. pombe) 0.44 NM_024190 Chmp1b Chromatin modifying protein 1B 0.41 NM_026885 Chmp2a Chromatin modifying protein 2A 0.40 NM_029814 Chmp5 Chromatin modifying protein 5 0.18 NM_027882 Cic Capicua homolog (Drosophila) 0.33 NM_007705 Cirbp Cold inducible RNA binding protein 0.42 NM_009895 Cish Cytokine inducible SH2-containing protein 0.30 NM_011334 Clcn4-2 Chloride channel 4-2 0.45 NM_008770 Cldn11 Claudin 11 0.32 NM_018778 Cldn8 Claudin 8 0.45 NM_001005860 Clec4a4 C-type lectin domain family 4, member a4 0.45 NM_133840 Clp1 CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) 0.45 NM_009191 Clpb ClpB caseinolytic peptidase B homolog (E. coli) 0.33

109 NM_017393 Clpp Caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) 0.38 NM_153384 Clrn1 Clarin 1 0.40 NM_153508 Clstn3 Calsyntenin 3 0.28 NM_001003908 Cltc , heavy polypeptide (Hc) 0.44 NM_028524 Cmtm2b CKLF-like MARVEL transmembrane domain containing 2B 0.45 NM_153582 Cmtm4 CKLF-like MARVEL transmembrane domain containing 4 0.40 NM_001039551 Cnnm3 Cyclin M3 0.43 NM_133724 Cno Cappuccino 0.40 NM_212484 Cnot6 CCR4-NOT transcription complex, subunit 6 0.33 NM_026562 Cntd1 Cyclin N-terminal domain containing 1 0.42 NM_016673 Cntfr Ciliary neurotrophic factor receptor 0.44 NM_007740 Col9a1 Procollagen, type IX, alpha 1 0.45 NM_144514 Commd1 COMM domain containing 1 0.40 NM_025536 Commd5 COMM domain containing 5 0.27 NM_019817 Copz1 Coatomer protein complex, subunit zeta 1 0.28 NM_178693 Coq4 Coenzyme Q4 homolog (yeast) 0.33 NM_172582 Coq6 Coenzyme Q6 homolog (yeast) 0.27 NM_030205 Coro7 Coronin 7 0.43 NM_007745 Cort Cortistatin 0.42 NM_009941 Cox4i1 Cytochrome c oxidase subunit IV isoform 1 0.43 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 0.37 NM_175342 Cphx Cytoplasmic polyadenylated homeobox 0.41 NM_175342 Cphx Cytoplasmic polyadenylated homeobox 0.41 NM_175342 Cphx Cytoplasmic polyadenylated homeobox 0.41 NM_028020 Cpsf3l Cleavage and polyadenylation specific factor 3-like 0.35 NM_013496 Crabp1 Cellular retinoic acid binding protein I 0.45 NM_013497 Creb3 CAMP responsive element binding protein 3 0.45 NM_001033638 Crxos1 Crx opposite strand transcript 1 0.45 NM_007771 Cry1 Cryptochrome 1 (photolyase-like) 0.41 NM_030004 Cryl1 Crystallin, lambda 1 0.43 NM_009974 Csnk2a2 , alpha prime polypeptide 0.32 NM_139001 Cspg4 Chondroitin sulfate proteoglycan 4 0.30 NM_031249 Cstf2t Cleavage stimulation factor, 3' pre-RNA subunit 2, tau 0.45 NM_145529 Cstf3 Cleavage stimulation factor, 3' pre-RNA, subunit 3 0.40 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small NM_153088 Ctdsp1 phosphatase 1 0.38 NM_007803 Cttn Cortactin 0.43 NM_010160 Cugbp2 CUG triplet repeat, RNA binding protein 2 0.43 NM_029402 Cul2 Cullin 2 0.39 NM_001025192 Cxadr Coxsackievirus and adenovirus receptor 0.41 NM_028868 Cxxc1 CXXC finger 1 (PHD domain) 0.42 NM_001004367 Cxxc4 CXXC finger 4 0.41 NM_001024926 Cyb5d2 Cytochrome b5 domain containing 2 0.23 NM_145499 Cyp2c70 Cytochrome P450, family 2, subfamily c, polypeptide 70 0.45 NM_022434 Cyp4f14 Cytochrome P450, family 4, subfamily f, polypeptide 14 0.34 NM_029491 D030074E01Rik RIKEN cDNA D030074E01 gene 0.31 NM_138601 D10Jhu81e DNA segment, Chr 10, Johns Hopkins University 81 expressed 0.45 NM_145422 D10Wsu52e DNA segment, Chr 10, Wayne State University 52, expressed 0.43 NM_025311 D14Ertd449e DNA segment, Chr 14, ERATO Doi 449, expressed 0.36 NM_025311 D14Ertd449e DNA segment, Chr 14, ERATO Doi 449, expressed 0.36 NM_025311 D14Ertd449e DNA segment, Chr 14, ERATO Doi 449, expressed 0.36 NM_029320 D14Ertd581e DNA segment, Chr 14, ERATO Doi 581, expressed 0.40 NM_172631 D18Ertd653e DNA segment, Chr 18, ERATO Doi 653, expressed 0.36 NM_177464 D19Ertd386e DNA segment, Chr 19, ERATO Doi 386, expressed 0.34 NM_178724 D230010M03Rik RIKEN cDNA D230010M03 gene 0.36 NM_178882 D2hgdh D-2-hydroxyglutarate dehydrogenase 0.30 NM_001033347 D430041D05Rik RIKEN cDNA D430041D05 gene 0.40 NM_138594 D6Wsu163e DNA segment, Chr 6, Wayne State University 163, expressed 0.45 NM_021294 Dbil5 Diazepam binding inhibitor-like 5 0.44

110 NM_010022 Dbt Dihydrolipoamide branched chain transacylase E2 0.30 NM_016890 Dctn3 Dynactin 3 0.28 NM_022563 Ddr2 Discoidin domain receptor family, member 2 0.41 NM_152806 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.43 NM_028038 Ddx28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 0.36 NM_028074 Ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.45 NM_026538 Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.45 NM_172689 Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.40 NM_207677 Dedd2 -containing DNA binding protein 2 0.42 NM_145157 Defb19 Defensin beta 19 0.41 NM_153551 Dennd1c DENN/MADD domain containing 1C 0.41 NM_172733 Dera 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) 0.44 NM_145428 Dhrs7b Dehydrogenase/reductase (SDR family) member 7B 0.37 NM_026191 Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.40 NM_144831 Dhx8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 0.45 NM_174853 Disc1 Disrupted in 1 0.34 NM_020265 Dkk2 Dickkopf homolog 2 (Xenopus laevis) 0.43 NM_015789 Dkkl1 Dickkopf-like 1 0.33 NM_007866 Dll3 Delta-like 3 (Drosophila) 0.42 NM_183312 Dmn Desmuslin 0.45 NM_025926 Dnajb4 DnaJ (Hsp40) homolog, subfamily B, member 4 0.38 NM_007869 Dnajc1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.44 NM_010065 Dnm1 Dynamin 1 0.38 NM_026082 Dedicator of cytokinesis 7 0.43 NM_176913 Dpep2 Dipeptidase 2 0.38 NM_027193 Dph5 DPH5 homolog (S. cerevisiae) 0.42 NM_010072 Dpm1 Dolichol-phosphate (beta-D) mannosyltransferase 1 0.41 NM_010073 Dpm2 Dolichol-phosphate (beta-D) mannosyltransferase 2 0.37 NM_026767 Dpm3 Dolichyl-phosphate mannosyltransferase polypeptide 3 0.41 NM_172624 Dpp9 Dipeptidylpeptidase 9 0.34 NM_007877 Drd3 Dopamine receptor 3 0.37 NM_026017 Dullard Dullard homolog (Xenopus laevis) 0.42 NM_001013826 Dupd1 Dual specificity phosphatase and pro isomerase domain containing 1 0.33 NM_028002 Dus4l Dihydrouridine synthase 4-like (S. cerevisiae) 0.35 NM_173745 Dusp18 Dual specificity phosphatase 18 0.38 NM_025869 Dusp26 Dual specificity phosphatase 26 (putative) 0.42 NM_030238 Dync1h1 Dynein cytoplasmic 1 heavy chain 1 0.31 NM_001013380 Dync1li2 Dynein, cytoplasmic 1 light intermediate chain 2 0.44 NM_029851 Dync2h1 Dynein cytoplasmic 2 heavy chain 1 0.42 NM_019682 Dynll1 Dynein light chain LC8-type 1 0.37 NM_178609 E2f7 E2F transcription factor 7 0.41 NM_001013368 E2f8 E2F transcription factor 8 0.33 NM_198011 E430018J23Rik RIKEN cDNA E430018J23 gene 0.43 NM_007893 E4F transcription factor 1 0.43 NM_028932 Eaf1 ELL associated factor 1 0.30 NM_026598 Ebpl Emopamil binding protein-like 0.44 NM_010333 Edg5 Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 0.44 NM_177665 EG229862 Predicted gene, EG229862 0.44 NM_177764 EG269902 Predicted gene, EG269902 0.42 NM_177808 EG328231 Predicted gene, EG328231 0.45 NM_183309 EG330305 Predicted gene, EG330305 0.42 NM_001025240 EG384813 Predicted gene, EG384813 0.45 NM_001034880 EG432838 Predicted gene, EG432838 0.41 NM_001034909 EG547347 Predicted gene, EG547347 0.40 NM_001034909 EG547347 Predicted gene, EG547347 0.40 NM_001037923 EG624866 Predicted gene, EG624866 0.40 NM_018781 Egr3 Early growth response 3 0.35 NM_145139 Eif3eip Eukaryotic translation initiation factor 3, subunit E interacting protein 0.35

111 NM_023743 Eif4enif1 Eukaryotic translation initiation factor 4E nuclear import factor 1 0.41 NM_181582 Eif5a Eukaryotic translation initiation factor 5A 0.25 NM_198303 Eif5b Eukaryotic translation initiation factor 5B 0.42 NM_010579 Eif6 Eukaryotic translation initiation factor 6 0.31 NM_007924 Ell Elongation factor RNA polymerase II 0.24 NM_080288 Elmo1 Engulfment and cell motility 1, ced-12 homolog (C. elegans) 0.32 NM_198093 Elmo1 Engulfment and cell motility 1, ced-12 homolog (C. elegans) 0.41 NM_001039175 Elovl1 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 0.42 NM_134255 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.43 NM_182840 Emilin3 Elastin microfibril interfacer 3 0.42 NM_010131 Emx1 Empty spiracles homolog 1 (Drosophila) 0.35 NM_010132 Emx2 Empty spiracles homolog 2 (Drosophila) 0.34 NM_172813 Enox1 Ecto-NOX disulfide-thiol exchanger 1 0.45 NM_053103 Entpd7 Ectonucleoside triphosphate diphosphohydrolase 7 0.33 NM_001006664 Epb4.1l1 Erythrocyte protein band 4.1-like 1 0.41 NM_134065 Epdr1 Ependymin related protein 1 (zebrafish) 0.44 NM_178085 Erc1 ELKS/RAB6-interacting/CAST family member 1 0.27 Excision repair cross-complementing rodent repair deficiency, complementation NM_015769 Ercc4 group 4 0.43 NM_007951 Erh Enhancer of rudimentary homolog (Drosophila) 0.28 NM_007954 Es1 Esterase 1 0.41 NM_144866 Etf1 Eukaryotic translation termination factor 1 0.43 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide 0.26 NM_175443 Etnk2 Ethanolamine kinase 2 0.41 NM_012051 Etv3 Ets variant gene 3 0.33 NM_023794 Etv5 Ets variant gene 5 0.45 NM_007966 Even skipped homeotic gene 1 homolog 0.43 NM_138586 Exosc5 Exosome component 5 0.40 NM_019393 Exosc9 Exosome component 9 0.40 NM_010162 Ext1 Exostoses (multiple) 1 0.28 NM_010634 Fabp5 Fatty acid binding protein 5, epidermal 0.43 NM_021272 Fabp7 Fatty acid binding protein 7, brain 0.36 NM_010176 Fah Fumarylacetoacetate hydrolase 0.45 NM_172422 Fastkd2 FAST kinase domains 2 0.32 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed NM_007990 Fau (fox derived) 0.28 NM_172748 Fbxl19 F-box and leucine-rich repeat protein 19 0.43 NM_175127 Fbxo28 F-box protein 28 0.38 NM_020593 Fbxo3 F-box protein 3 0.39 NM_015791 Fbxo8 F-box protein 8 0.45 NM_177070 Fbxw16 F-box and WD-40 domain protein 16 0.39 NM_144960 Fcamr Fc receptor, IgA, IgM, high affinity 0.42 NM_028632 Fcf1 FCF1 small subunit (SSU) processome component homolog (S. cerevisiae) 0.27 NM_175684 Fchsd1 FCH and double SH3 domains 1 0.29 NM_199012 Fchsd2 FCH and double SH3 domains 2 0.45 NM_178165 Fcrl1 Fc receptor-like 1 0.39 NM_001029984 Fcrlb Fc receptor-like B 0.44 NM_134469 Fdps Farnesyl diphosphate synthetase 0.32 NM_010194 Fes Feline sarcoma oncogene 0.26 NM_146187 Ffar2 Free fatty acid receptor 2 0.36 NM_010198 Fgf11 Fibroblast growth factor 11 0.38 NM_028263 Fgfbp3 Fibroblast growth factor binding protein 3 0.38 NM_010206 Fgfr1 Fibroblast growth factor receptor 1 0.40 NM_201230 Fgfr1op Fgfr1 oncogene partner 0.40 NM_010209 Fh1 Fumarate hydratase 1 0.21 NM_019873 Fkbpl FK506 binding protein-like 0.41 NM_177041 Flad1 RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) 0.35 NM_146018 Flcn Folliculin 0.38 NM_001040403 Flot2 Flotillin 2 0.42

112 NM_018828 Fnbp4 Formin binding protein 4 0.42 NM_010234 Fos FBJ osteosarcoma oncogene 0.45 NM_021899 Foxj2 Forkhead box J2 0.43 NM_183186 Foxn3 Forkhead box N3 0.39 NM_019740 Foxo3a Forkhead box O3a 0.39 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 0.32 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 0.32 NM_011936 Fto mass and obesity associated 0.43 NM_133991 Ftsj1 FtsJ homolog 1 (E. coli) 0.41 NM_148925 Fyco1 FYVE and coiled-coil domain containing 1 0.42 NM_008057 Fzd7 Frizzled homolog 7 (Drosophila) 0.44 NM_026693 Gabarapl2 Gamma-aminobutyric acid (GABA-A) receptor-associated protein-like 2 0.44 NM_172512 Gabpb2 GA repeat binding protein, beta 2 0.41 NM_177408 Gabrg2 Gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2 0.43 NM_007836 Gadd45a Growth arrest and DNA-damage-inducible 45 alpha 0.40 NM_001033416 Gal3st4 Galactose-3-O-sulfotransferase 4 0.36 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_144908 Galnt11 acetylgalactosaminyltransferase 11 0.36 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_172855 Galnt5 acetylgalactosaminyltransferase 5 0.37 NM_010255 Gamt Guanidinoacetate methyltransferase 0.36 NM_025961 Gatm Glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.27 NM_010259 Gbp1 Guanylate nucleotide binding protein 1 0.43 NM_013847 Gcat Glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) 0.40 NM_028900 Gcc1 Golgi coiled coil 1 0.34 NM_008105 Gcnt2 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme 0.29 NM_010269 Gdap2 Ganglioside-induced differentiation-associated-protein 2 0.40 NM_172558 Gemin5 Gem (nuclear ) associated protein 5 0.44 NM_013528 Gfpt1 Glutamine fructose-6-phosphate transaminase 1 0.33 NM_020014 Gfra4 Glial cell line derived neurotrophic factor family receptor alpha 4 0.36 NM_145929 Gga1 Golgi associated, gamma adaptin ear containing, ARF binding protein 1 0.30 NM_001003685 Ghrhr Growth hormone releasing hormone receptor 0.44 NM_019832 Gkap1 G kinase anchoring protein 1 0.42 NM_025466 Gkn1 Gastrokine 1 0.35 NM_033320 Glce Glucuronyl C5-epimerase 0.39 NM_175681 Glp2r Glucagon-like peptide 2 receptor 0.43 NM_008132 Glrp1 Glutamine repeat protein 1 0.44 NM_153601 Gluld1 Glutamate- ligase () domain containing 1 0.44 NM_001033478 Gm1381 Gene model 1381, (NCBI) 0.42 NM_001033452 Gm1967 Gene model 1967, (NCBI) 0.39 NM_001005419 Gm237 Gene model 237, (NCBI) 0.31 NM_001033252 Gm732 Gene model 732, (NCBI) 0.32 NM_001033407 Gm815 Gene model 815, (NCBI) 0.41 NM_001033428 Gm854 Gene model 854, (NCBI) 0.34 NM_001033435 Gm885 Gene model 885, (NCBI) 0.40 NM_010303 Gna13 Guanine nucleotide binding protein, alpha 13 0.41 NM_010322 Gnpat Glyceronephosphate O-acyltransferase 0.30 NM_008146 Golga3 Golgi autoantigen, golgin subfamily a, 3 0.31 NM_010331 Gpaa1 GPI anchor attachment protein 1 0.38 NM_016696 Gpc1 Glypican 1 0.43 NM_173747 Gpkow G patch domain and KOW motifs 0.40 NM_030084 Gpr108 G protein-coupled receptor 108 0.45 NM_133776 Gpr110 G protein-coupled receptor 110 0.43 NM_181752 Gpr135 G protein-coupled receptor 135 0.37 NM_153394 Gpr156 G protein-coupled receptor 156 0.15 NM_177366 Gpr157 G protein-coupled receptor 157 0.24 NM_008154 Gpr3 G-protein coupled receptor 3 0.32 NM_175669 Gpr82 G protein-coupled receptor 82 0.45 NM_145370 Gps1 G protein pathway suppressor 1 0.41

113 NM_013535 Grcc10 Gene rich cluster, C10 gene 0.41 NM_010349 Grik2 Glutamate receptor, ionotropic, kainate 2 (beta 2) 0.40 NM_019497 Grk4 G protein-coupled receptor kinase 4 0.35 NM_008175 Grn Granulin 0.27 NM_153419 Grwd1 Glutamate-rich WD repeat containing 1 0.24 NM_001031667 Gsk3a kinase 3 alpha 0.30 NM_010360 Gstm5 Glutathione S-transferase, mu 5 0.37 NM_008184 Gstm6 Glutathione S-transferase, mu 6 0.43 NM_023630 Gtf2a1l General transcription factor IIA, 1-like 0.27 NM_133801 Gtf2f1 General transcription factor IIF, polypeptide 1 0.35 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 0.43 NM_181410 Gtf2h3 General transcription factor IIH, polypeptide 3 0.33 NM_207239 Gtf3c1 General transcription factor III C 1 0.32 NM_148928 Gtf3c5 General transcription factor IIIC, polypeptide 5 0.44 NM_153116 Gtpbp10 GTP-binding protein 10 (putative) 0.25 NM_032544 Gtpbp3 GTP binding protein 3 0.22 NM_027000 Gtpbp4 GTP binding protein 4 0.40 NM_181424 Gtpbp5 GTP binding protein 5 0.43 NM_008191 Guca2b Guanylate cyclase activator 2b () 0.37 NM_008194 Gyk Glycerol kinase 0.45 NM_027304 H1fnt H1 histone family, member N, testis-specific 0.37 NM_177923 H2-M10.2 Histocompatibility 2, M region locus 10.2 0.45 NM_010395 H2-T10 Histocompatibility 2, T region locus 10 0.37 NM_008211 H3f3b H3 histone, family 3B 0.42 NM_026897 Haghl Hydroxyacylglutathione hydrolase-like 0.40 NM_008225 Hcls1 Hematopoietic cell specific Lyn substrate 1 0.44 NM_198962 Hcrtr2 Hypocretin (orexin) receptor 2 0.42 NM_008228 Hdac1 Histone deacetylase 1 0.44 NM_024257 Hdhd3 Haloacid dehalogenase-like hydrolase domain containing 3 0.37 NM_001033432 Heca Headcase homolog (Drosophila) 0.41 NM_008237 Hes3 Hairy and enhancer of split 3 (Drosophila) 0.36 NM_025798 Hint3 Histidine triad nucleotide binding protein 3 0.38 NM_172746 Hirip3 HIRA interacting protein 3 0.25 NM_178182 Hist1h2ai Histone cluster 1, H2ai 0.39 NM_178194 Hist1h2be Histone cluster 1, H2be 0.30 NM_175655 Hist1h4f Histone cluster 1, H4f 0.37 NM_178212 Hist2h2aa2 Histone cluster 2, H2aa2 0.41 NM_178212 Hist2h2aa2 Histone cluster 2, H2aa2 0.41 NM_178214 Hist2h2be Histone cluster 2, H2be 0.38 NM_019469 Hist2h3b Histone cluster 2, H3b 0.38 NM_013820 Hk2 Hexokinase 2 0.38 NM_013551 Hmbs Hydroxymethylbilane synthase 0.37 NM_173731 Hmgcll1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 0.44 NM_001039129 Hnrnpa1 Heterogeneous nuclear ribonucleoprotein A1 0.40 NM_019868 Hnrph2 Heterogeneous nuclear ribonucleoprotein H2 0.37 NM_010454 Hoxa6 Homeo box A6 0.44 NM_010461 Hoxb8 Homeo box B8 0.43 NM_008270 Hoxb9 Homeo box B9 0.31 NM_010463 Hoxc12 Homeo box C12 0.42 NM_010470 Hp1bp3 Heterochromatin protein 1, binding protein 3 0.40 NM_008277 Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.35 NM_016763 Hsd17b10 Hydroxysteroid (17-beta) dehydrogenase 10 0.44 NM_019657 Hsd17b12 Hydroxysteroid (17-beta) dehydrogenase 12 0.42 NM_197944 Hsh2d Hematopoietic SH2 domain containing 0.41 NM_008302 Hsp90ab1 Heat shock protein 90kDa alpha (cytosolic), class B member 1 0.30 NM_008309 Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.42 NM_015755 Hunk Hormonally upregulated Neu-associated kinase 0.41 NM_021523 Huwe1 HECT, UBA and WWE domain containing 1 0.45

114 NM_008317 Hyal1 Hyaluronoglucosaminidase 1 0.31 NM_008319 Icam5 Intercellular adhesion molecule 5, telencephalin 0.38 NM_008321 Id3 Inhibitor of DNA binding 3 0.20 NM_133662 Ier3 Immediate early response 3 0.45 NM_053088 Ifitm5 Interferon induced transmembrane protein 5 0.41 NM_197889 Ifnz Interferon zeta 0.41 NM_013562 Ifrd1 Interferon-related developmental regulator 1 0.42 NM_031177 Ift122 Intraflagellar transport 122 homolog (Chlamydomonas) 0.37 NM_134126 Ift140 Intraflagellar transport 140 homolog (Chlamydomonas) 0.35 NM_009879 Ift81 Intraflagellar transport 81 homolog (Chlamydomonas) 0.42 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 0.30 NM_033608 Igsf9 Immunoglobulin superfamily, member 9 0.43 NM_001033323 Igsf9b Immunoglobulin superfamily, member 9B 0.37 Inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex- NM_026079 Ikbkap associated protein 0.37 NM_008348 Il10ra Interleukin 10 receptor, alpha 0.44 NM_008350 Il11 Interleukin 11 0.35 NM_010550 Il11ra2 Interleukin 11 receptor, alpha chain 2 0.37 NM_010550 Il11ra2 Interleukin 11 receptor, alpha chain 2 0.37 NM_019450 Il1f6 Interleukin 1 family, member 6 0.30 NM_008364 Il1rap Interleukin 1 receptor accessory protein 0.37 NM_010743 Il1rl1 Interleukin 1 receptor-like 1 0.43 NM_001039701 Il1rn Interleukin 1 receptor antagonist 0.39 NM_010560 Il6st signal transducer 0.45 NM_023343 Ilkap Integrin-linked kinase-associated serine/threonine phosphatase 2C 0.40 NM_018864 Impa1 Inositol (myo)-1(or 4)-monophosphatase 1 0.41 NM_016692 Incenp Inner centromere protein 0.28 NM_023503 Ing2 Inhibitor of growth family, member 2 0.35 NM_133345 Ing4 Inhibitor of growth family, member 4 0.29 NM_008380 Inhba Inhibin beta-A 0.38 NM_010565 Inhbc Inhibin beta-C 0.43 NM_030266 Inpp4a Inositol polyphosphate-4-phosphatase, type I 0.40 NM_183144 Inpp5a Inositol polyphosphate-5-phosphatase A 0.44 NM_010566 Inpp5d Inositol polyphosphate-5-phosphatase D 0.44 NM_001033354 Iqsec3 IQ motif and Sec7 domain 3 0.39 NM_153134 Irgq Immunity-related GTPase family, Q 0.42 NM_001001309 Itga8 Integrin alpha 8 0.40 NM_013712 Itgb1bp2 Integrin beta 1 binding protein 2 0.39 NM_172471 Itih5 Inter-alpha (globulin) inhibitor H5 0.42 NM_029842 Jmjd5 Jumonji domain containing 5 0.43 NM_025368 Josd2 Josephin domain containing 2 0.39 NM_001003829 Jph4 Junctophilin 4 0.39 NM_010590 Jub Ajuba 0.25 NM_030887 Jundm2 Jun dimerization protein 2 0.40 NM_019697 Kcnd2 Potassium voltage-gated channel, Shal-related family, member 2 0.45 NM_008424 Kcne1 Potassium voltage-gated channel, Isk-related subfamily, member 1 0.34 NM_021342 Kcne4 Potassium voltage-gated channel, Isk-related subfamily, gene 4 0.42 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 0.43 NM_177791 Kctd19 Potassium channel tetramerisation domain containing 19 0.15 NM_025888 Kctd20 Potassium channel tetramerisation domain containing 20 0.43 NM_134073 Kctd9 Potassium channel tetramerisation domain containing 9 0.40 NM_011317 Khdrbs1 KH domain containing, RNA binding, associated 1 0.41 NM_016705 Kif21a Kinesin family member 21A 0.45 NM_134471 Kif2c Kinesin family member 2C 0.35 NM_008445 Kif3c Kinesin family member 3C 0.28 NM_010628 Kif9 Kinesin family member 9 0.24 NM_010630 Kifc2 Kinesin family member C2 0.45 NM_010635 Klf1 Kruppel-like factor 1 (erythroid) 0.40 NM_025707 Klhl28 Kelch-like 28 (Drosophila) 0.31

115 NM_019928 Klk4 Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) 0.23 NM_133727 Kptn Kaptin 0.40 NM_021284 Kras V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.44 NM_008473 Krt1 0.33 NM_133730 Krt25 Keratin 25 0.43 NM_031170 Krt8 0.44 NM_010673 Krtap6-2 Keratin associated protein 6-2 0.38 NM_001033131 Krtdap Keratinocyte differentiation associated protein 0.39 NM_010679 Lalba Lactalbumin, alpha 0.45 NM_010686 Laptm5 Lysosomal-associated protein transmembrane 5 0.41 NM_010686 Laptm5 Lysosomal-associated protein transmembrane 5 0.41 NM_001024526 Larp4 La ribonucleoprotein domain family, member 4 0.39 NM_138593 Larp7 La ribonucleoprotein domain family, member 7 0.41 NM_010688 Lasp1 LIM and SH3 protein 1 0.40 NM_008489 Lbp Lipopolysaccharide binding protein 0.29 NM_025413 Lce1g Late cornified envelope 1G 0.37 NM_010702 Lect2 Leukocyte cell-derived chemotaxin 2 0.41 NM_001033250 Lemd1 LEM domain containing 1 0.45 NM_019516 Lgals12 Lectin, galactose binding, soluble 12 0.41 NM_020278 Lgi1 Leucine-rich repeat LGI family, member 1 0.45 NM_008500 Lhx6 LIM homeobox protein 6 0.34 NM_010715 Lig1 Ligase I, DNA, ATP-dependent 0.31 NM_010718 Limk2 LIM motif-containing protein kinase 2 0.45 NM_026148 Lims1 LIM and senescent cell antigen-like domains 1 0.35 NM_181074 Lingo1 Leucine rich repeat and Ig domain containing 1 0.45 NM_177250 Lingo4 Leucine rich repeat and Ig domain containing 4 0.45 NM_152815 Lins2 Lines homolog 2 (Drosophila) 0.40 NM_172837 Lipk Lipase, family member K 0.28 NM_026719 Lmbrd1 LMBR1 domain containing 1 0.42 NM_010723 Lmo4 LIM domain only 4 0.45 NM_172827 Lnpep Leucyl/cystinyl aminopeptidase 0.43 NM_023052 LOC100042493 Similar to beta chemokine Exodus-2 0.37 NM_023052 LOC100042493 Similar to beta chemokine Exodus-2 0.37 NM_023052 LOC100042493 Similar to beta chemokine Exodus-2 0.37 NM_008508 Lor Loricrin 0.40 NM_010728 Lox Lysyl oxidase 0.45 NM_033325 Loxl2 Lysyl oxidase-like 2 0.37 NM_001033439 Lrch1 Leucine-rich repeats and calponin homology (CH) domain containing 1 0.44 NM_146164 Lrch4 Leucine-rich repeats and calponin homology (CH) domain containing 4 0.35 NM_153521 Lrrc41 Leucine rich repeat containing 41 0.25 NM_153545 Lrrc45 Leucine rich repeat containing 45 0.44 NM_026648 Lrrc50 Leucine rich repeat containing 50 0.38 NM_177725 Lrrc8a Leucine rich repeat containing 8A 0.45 NM_146191 Lrrk1 Leucine-rich repeat kinase 1 0.44 NM_025730 Lrrk2 Leucine-rich repeat kinase 2 0.34 NM_025948 Lsm14a LSM14 homolog A (SCD6, S. cerevisiae) 0.36 NM_008523 Ltk Leukocyte tyrosine kinase 0.38 NM_020498 Ly6i Lymphocyte antigen 6 complex, locus I 0.36 NM_025281 Lyar Ly1 reactive clone 0.40 NM_153121 Lysmd1 LysM, putative peptidoglycan-binding, domain containing 1 0.36 NM_020019 Magea6 Melanoma antigen, family A, 6 0.40 NM_053201 Magee1 Melanoma antigen, family E, 1 0.40 NM_174857 Mamdc2 MAM domain containing 2 0.37 NM_008928 Map2k3 Mitogen activated protein kinase kinase 3 0.33 NM_022012 Map3k11 Mitogen activated protein kinase kinase kinase 11 0.29 NM_016896 Map3k14 Mitogen-activated protein kinase kinase kinase 14 0.30 NM_011947 Map3k3 Mitogen activated protein kinase kinase kinase 3 0.43 NM_011948 Map3k4 Mitogen activated protein kinase kinase kinase 4 0.37

116 NM_138667 Map3k7ip2 Mitogen-activated protein kinase kinase kinase 7 interacting protein 2 0.42 NM_016700 Mapk8 Mitogen activated protein kinase 8 0.42 NM_007928 Mark2 MAP/microtubule affinity-regulating kinase 2 0.41 NM_212447 Marveld3 MARVEL (membrane-associating) domain containing 3 0.44 NM_033072 Mbd6 Methyl-CpG binding domain protein 6 0.24 NM_145442 Mbip MAP3K12 binding inhibitory protein 1 0.35 NM_026037 Mboat2 Membrane bound O-acyltransferase domain containing 2 0.28 NM_178076 Mcf2l Mcf.2 transforming sequence-like 0.43 NM_008564 Mcm2 Minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.36 NM_008566 Mcm5 Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.40 NM_010787 Mea1 Male enhanced antigen 1 0.33 NM_025297 Mecr Mitochondrial trans-2-enoyl-CoA reductase 0.29 Mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. NM_138596 Med10 cerevisiae) 0.43 NM_020048 Med20 Mediator complex subunit 20 0.31 NM_026068 Med31 Mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) 0.39 NM_008578 Mef2b Myocyte enhancer factor 2B 0.40 NM_144913 Mepce Methylphosphate capping enzyme 0.39 NM_010792 Mettl1 Methyltransferase-like 1 0.37 NM_008546 Mfap2 Microfibrillar-associated protein 2 0.38 NM_029662 Mfsd2 Major facilitator superfamily domain containing 2 0.20 NM_027122 Mfsd3 Major facilitator superfamily domain containing 3 0.45 NM_008601 Mitf Microphthalmia-associated transcription factor 0.40 NM_177582 Mlxip MLX interacting protein 0.39 NM_008609 Mmp15 Matrix metallopeptidase 15 0.42 NM_032007 Mmp1b Matrix metallopeptidase 1b (interstitial collagenase) 0.41 NM_010808 Mmp24 Matrix metallopeptidase 24 0.34 NM_080453 Mmp28 Matrix metallopeptidase 28 (epilysin) 0.42 NM_010810 Mmp7 Matrix metallopeptidase 7 0.31 NM_019944 Mnx1 Motor neuron and pancreas homeobox 1 0.31 NM_010816 Morc1 Microrchidia 1 0.40 NM_001039147 Morf4l1 Mortality factor 4 like 1 0.35 NM_030037 Mospd3 Motile sperm domain containing 3 0.38 NM_019939 Mpp6 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) 0.32 NM_138670 Mpst Mercaptopyruvate sulfurtransferase 0.44 NM_007962 Mpzl2 Myelin protein zero-like 2 0.44 NM_008625 Mrc1 , C type 1 0.38 NM_207539 Mrgprb8 MAS-related GPR, member B8 0.43 NM_001034868 Mrgprx2 MAS-related GPR, member X2 0.36 NM_145433 Mrm1 Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 0.42 NM_025606 Mrpl16 Mitochondrial ribosomal protein L16 0.37 NM_025301 Mrpl17 Mitochondrial ribosomal protein L17 0.33 NM_053162 Mrpl34 Mitochondrial ribosomal protein L34 0.33 NM_025430 Mrpl35 Mitochondrial ribosomal protein L35 0.44 NM_024177 Mrpl38 Mitochondrial ribosomal protein L38 0.41 NM_025595 Mrpl51 Mitochondrial ribosomal protein L51 0.42 NM_026498 Mrps11 Mitochondrial ribosomal protein S11 0.29 NM_021556 Mrps30 Mitochondrial ribosomal protein S30 0.29 NM_023260 Mrps34 Mitochondrial ribosomal protein S34 0.31 NM_025369 Mrps36 Mitochondrial ribosomal protein S36 0.30 NM_026422 Mrrf Mitochondrial ribosome recycling factor 0.38 NM_008629 Msi1 Musashi homolog 1(Drosophila) 0.41 NM_054043 Msi2 Musashi homolog 2 (Drosophila) 0.41 NM_144898 Msto1 Misato homolog 1 (Drosophila) 0.43 NM_177293 Mtap7d3 MAP7 domain containing 3 0.44 NM_134092 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein 0.29 NM_008636 Mtf1 Metal response element binding transcription factor 1 0.44 NM_172761 Mthfsd Methenyltetrahydrofolate synthetase domain containing 0.45 NM_133767 Mtif2 Mitochondrial translational initiation factor 2 0.42

117 NM_175374 Mtrf1l Mitochondrial translational release factor 1-like 0.45 NM_001005865 Mtus1 Mitochondrial tumor suppressor 1 0.44 NM_023166 Mtvr2 Mammary tumor virus receptor 2 0.33 NM_013605 Muc1 Mucin 1, transmembrane 0.34 NM_172979 Muc15 Mucin 15 0.36 NM_027877 Mus81 MUS81 endonuclease homolog (yeast) 0.44 NM_010846 Mx1 Myxovirus (influenza virus) resistance 1 0.42 NM_008654 Myd116 Myeloid differentiation primary response gene 116 0.38 NM_175260 Myh10 Myosin, heavy polypeptide 10, non-muscle 0.32 NM_010859 Myl3 Myosin, light polypeptide 3 0.30 NM_010865 Myoc Myocilin 0.40 NM_031189 Myog 0.42 NM_177239 Mysm1 Myb-like, SWIRM and MPN domains 1 0.44 NM_177619 Myst2 MYST histone acetyltransferase 2 0.26 NM_153591 Nars2 Asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) 0.44 NM_016777 Nasp Nuclear autoantigenic sperm protein (histone-binding) 0.34 NM_026425 Nat5 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) 0.44 NM_007789 Ncan Neurocan 0.43 NM_134009 Ncln Nicalin homolog (zebrafish) 0.39 NM_023294 Ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.45 NM_025348 Ndufa3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 0.20 NM_025316 Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 0.43 NM_010888 Ndufs6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 0.24 NM_133666 Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.35 NM_028757 Nebl 0.42 NM_011848 Nek3 NIMA (never in mitosis gene a)-related expressed kinase 3 0.43 NM_080849 Nek8 NIMA (never in mitosis gene a)-related expressed kinase 8 0.33 NM_001037906 Nell1 NEL-like 1 () 0.45 NM_028728 Nfam1 Nfat activating molecule with ITAM motif 1 0.36 NM_008687 Nfib /B 0.44 NM_023739 Nfx1 Nuclear transcription factor, X-box binding 1 0.32 NM_026890 Ngdn Neuroguidin, EIF4E binding protein 0.40 NM_010920 Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.35 NM_001002894 Nlrp14 NLR family, pyrin domain containing 14 0.38 NM_145827 Nlrp3 NLR family, pyrin domain containing 3 0.33 NM_178071 Nme7 Non-metastatic cells 7, protein expressed in 0.40 NM_008707 Nmt1 N-myristoyltransferase 1 0.39 NM_001039351 Nolc1 Nucleolar and coiled-body phosphoprotein 1 0.42 NM_175263 Notum Notum pectinacetylesterase homolog (Drosophila) 0.27 NM_146150 Nrd1 Nardilysin, N-arginine dibasic convertase, NRD convertase 1 0.44 NM_153529 Nrn1 Neuritin 1 0.40 NM_028142 Nsun4 NOL1/NOP2/Sun domain family, member 4 0.37 NM_008742 Ntf3 Neurotrophin 3 0.32 NM_011955 Nubp1 Nucleotide binding protein 1 0.40 NM_016773 Nucb2 Nucleobindin 2 0.24 NM_173748 Nudcd3 NudC domain containing 3 0.32 NM_008637 Nudt1 Nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.31 NM_153136 Nudt18 Nudix (nucleoside diphosphate linked moiety X)-type motif 18 0.30 NM_025539 Nudt2 Nudix (nucleoside diphosphate linked moiety X)-type motif 2 0.44 NM_175749 Nup153 Nucleoporin 153 0.45 NM_198304 Nup188 Nucleoporin 188 0.35 NM_053074 Nup62 Nucleoporin 62 0.43 NM_001002929 Nup85 Nucleoporin 85 0.44 NM_172410 Nup93 Nucleoporin 93 0.45 NM_175360 Obfc1 Oligonucleotide/oligosaccharide-binding fold containing 1 0.41 NM_027257 Obfc2b Oligonucleotide/oligosaccharide-binding fold containing 2B 0.45 NM_013614 Odc1 decarboxylase, structural 1 0.40 NM_133859 Olfml3 Olfactomedin-like 3 0.39

118 NM_001011721 Olfr100 Olfactory receptor 100 0.40 NM_146573 Olfr1002 Olfactory receptor 1002 0.45 NM_146834 Olfr101 Olfactory receptor 101 0.45 NM_146843 Olfr1097 Olfactory receptor 1097 0.37 NM_146845 Olfr1098 Olfactory receptor 1098 0.36 NM_146632 Olfr116 Olfactory receptor 116 0.45 NM_146343 Olfr1265 Olfactory receptor 1265 0.38 NM_146390 Olfr1323 Olfactory receptor 1323 0.37 NM_207157 Olfr1333 Olfactory receptor 1333 0.35 NM_146852 Olfr1339 Olfactory receptor 1339 0.42 NM_146283 Olfr1366 Olfactory receptor 1366 0.19 NM_207573 Olfr1380 Olfactory receptor 1380 0.42 NM_146469 Olfr1381 Olfactory receptor 1381 0.41 NM_001011790 Olfr1382 Olfactory receptor 1382 0.37 NM_146472 Olfr1384 Olfactory receptor 1384 0.42 NM_001011741 Olfr1386 Olfactory receptor 1386 0.37 NM_146467 Olfr1388 Olfactory receptor 1388 0.29 NM_147065 Olfr1390 Olfactory receptor 1390 0.39 NM_207665 Olfr144 Olfactory receptor 144 0.40 NM_207132 Olfr1471 Olfactory receptor 1471 0.45 NM_146301 Olfr1475 Olfactory receptor 1475 0.45 NM_020513 Olfr1508 Olfactory receptor 1508 0.41 NM_020598 Olfr17 Olfactory receptor 17 0.42 NM_146269 Olfr247 Olfactory receptor 247 0.29 NM_146269 Olfr247 Olfactory receptor 247 0.29 NM_146416 Olfr290 Olfactory receptor 290 0.26 NM_146415 Olfr291 Olfactory receptor 291 0.34 NM_207235 Olfr358 Olfactory receptor 358 0.44 NM_146374 Olfr368 Olfactory receptor 368 0.44 NM_146443 Olfr382 Olfactory receptor 382 0.39 NM_146710 Olfr398 Olfactory receptor 398 0.40 NM_001011863 Olfr406 Olfactory receptor 406 0.40 NM_146709 Olfr411 Olfactory receptor 411 0.38 NM_147063 Olfr520 Olfactory receptor 520 0.42 NM_146953 Olfr531 Olfactory receptor 531 0.45 NM_147101 Olfr549 Olfactory receptor 549 0.40 NM_147041 Olfr57 Olfactory receptor 57 0.35 NM_206897 Olfr6 Olfactory receptor 6 0.36 NM_147094 Olfr606 Olfactory receptor 606 0.37 NM_147056 Olfr646 Olfactory receptor 646 0.36 NM_146355 Olfr692 Olfactory receptor 692 0.40 NM_207147 Olfr813 Olfactory receptor 813 0.34 NM_146861 Olfr9 Olfactory receptor 9 0.43 NM_146810 Olfr912 Olfactory receptor 912 0.42 NM_146375 Olfr918 Olfactory receptor 918 0.31 NM_001011812 Olfr951 Olfactory receptor 951 0.31 NM_001011826 Olfr967 Olfactory receptor 967 0.33 NM_205822 Omt2b Oocyte maturation, beta 0.39 NM_178657 Oog1 Oogenesin 1 0.34 NM_207525 Opa3 Optic atrophy 3 (human) 0.43 NM_178751 Orai2 ORAI calcium release-activated calcium modulator 2 0.43 NM_025661 Ormdl3 ORM1-like 3 (S. cerevisiae) 0.29 NM_001003717 Osbpl8 Oxysterol binding protein-like 8 0.45 NM_008769 Otc Ornithine transcarbamylase 0.34 NM_139310 Otoa Otoancorin 0.44 NM_001013787 OTTMUSG00000000514 Predicted gene, OTTMUSG00000000514 0.42 NM_001007584 OTTMUSG00000002038 Predicted gene, OTTMUSG00000002038 0.27 NM_001037928 OTTMUSG00000005148 Predicted gene, OTTMUSG00000005148 0.45

119 NM_001013783 OTTMUSG00000005491 Predicted gene, OTTMUSG00000005491 0.35 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.42 NM_026580 Otub2 OTU domain, ubiquitin aldehyde binding 2 0.43 NM_145460 Oxnad1 Oxidoreductase NAD-binding domain containing 1 0.40 NM_008773 P2ry2 Purinergic receptor P2Y, G-protein coupled 2 0.45 NM_145579 P42pop Myb protein P42POP 0.38 NM_133880 Pafah2 Platelet-activating factor acetylhydrolase 2 0.45 NM_053182 Pag1 Phosphoprotein associated with glycosphingolipid microdomains 1 0.41 Phosphoribosylaminoimidazole carboxylase, NM_025939 Paics phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase 0.36 NM_146169 Paip2b Poly(A) binding protein interacting protein 2B 0.38 NM_172868 Palm2 Paralemmin 2 0.36 NM_019482 Panx1 Pannexin 1 0.41 NM_133905 Papd4 PAP associated domain containing 4 0.38 NM_172555 Papolg Poly(A) polymerase gamma 0.36 NM_027995 Paqr7 Progestin and adipoQ receptor family member VII 0.36 NM_019695 Pard6a Par-6 (partitioning defective 6,) homolog alpha (C. elegans) 0.35 NM_011960 Parg Poly (ADP-ribose) glycohydrolase 0.33 NM_001005767 Parl associated, rhomboid-like 0.33 NM_008781 Pax3 Paired box gene 3 0.32 NM_008782 Pax5 Paired box gene 5 0.37 NM_021568 Pcbp3 Poly(rC) binding protein 3 0.43 NM_011043 Pcdh10 Protocadherin 10 0.42 NM_023115 Pcdh15 Protocadherin 15 0.43 NM_001003672 Pcdha11 Protocadherin alpha 11 0.25 NM_009545 Pcgf2 Polycomb group ring finger 2 0.41 NM_011045 Pcna Proliferating cell nuclear antigen 0.36 NM_001024622 Pcnp PEST proteolytic signal containing nuclear protein 0.40 NM_172832 Pcyox1l Prenylcysteine oxidase 1 like 0.44 NM_011053 Pdcd11 Programmed cell death protein 11 0.20 NM_026850 Pdcl3 Phosducin-like 3 0.45 NM_008801 Pde6d Phosphodiesterase 6D, cGMP-specific, rod, delta 0.30 NM_026441 Pef1 Penta-EF hand domain containing 1 0.34 NM_153796 Peo1 Progressive external ophthalmoplegia 1 (human) 0.38 NM_026951 Pex11c Peroxisomal biogenesis factor 11c 0.33 NM_021483 Pex2 2 0.40 NM_011070 Pfdn2 Prefoldin 2 0.40 NM_207263 Pglyrp4 Peptidoglycan recognition protein 4 0.33 NM_007905 Phc1 Polyhomeotic-like 1 (Drosophila) 0.38 NM_153412 Phldb2 Pleckstrin homology-like domain, family B, member 2 0.45 NM_175356 Pi4kb Phosphatidylinositol 4-kinase, catalytic, beta polypeptide 0.43 NM_021501 Pias4 Protein inhibitor of activated STAT 4 0.40 NM_181414 Pik3c3 Phosphoinositide-3-kinase, class 3 0.39 NM_181585 Pik3r3 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) 0.42 NM_011098 Pitx2 Paired-like homeodomain transcription factor 2 0.34 NM_008861 Pkd2 Polycystic kidney disease 2 0.41 NM_016915 Pla2g6 Phospholipase A2, group VI 0.34 NM_008873 Plau Plasminogen activator, urokinase 0.25 NM_013746 Plekhb1 Pleckstrin homology domain containing, family B (evectins) member 1 0.45 NM_011962 Plod3 Procollagen-, 2-oxoglutarate 5-dioxygenase 3 0.37 NM_011123 Plp1 Proteolipid protein (myelin) 1 0.42 NM_025928 Pmf1 Polyamine-modulated factor 1 0.45 NM_008884 Pml Promyelocytic leukemia 0.44 NM_016881 Pmm2 Phosphomannomutase 2 0.38 NM_001039509 Pnkd Paroxysmal nonkinesiogenic dyskinesia 0.42 NM_008891 Pnn Pinin 0.42 NM_008892 Pola1 Polymerase (DNA directed), alpha 1 0.21 NM_011132 Pole Polymerase (DNA directed), epsilon 0.43 NM_017462 Polg Polymerase (DNA directed), gamma 0.39

120 NM_025624 Pomp Proteasome maturation protein 0.39 NM_145145 Pomt1 Protein-O-mannosyltransferase 1 0.44 NM_008902 Pp11r Placental protein 11 related 0.45 NM_008247 Ppap2a Phosphatidic acid phosphatase 2a 0.39 NM_015817 Ppap2c Phosphatidic acid phosphatase type 2c 0.44 NM_176831 Ppcdc Phosphopantothenoylcysteine decarboxylase 0.22 NM_175363 Pphln1 Periphilin 1 0.40 NM_028292 Ppme1 Protein phosphatase methylesterase 1 0.43 NM_013636 Ppp1cc Protein phosphatase 1, catalytic subunit, gamma isoform 0.37 NM_133485 Ppp1r14c Protein phosphatase 1, regulatory (inhibitor) subunit 14c 0.25 NM_138605 Ppp1r3f Protein phosphatase 1, regulatory (inhibitor) subunit 3F 0.45 NM_021529 Ppp2r3c Protein phosphatase 2, regulatory subunit B'', gamma 0.33 NM_024459 Ppp3r1 Protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) 0.35 NM_008917 Ppt1 Palmitoyl-protein thioesterase 1 0.28 NM_172574 Pqlc3 PQ loop repeat containing 0.43 NM_138602 Praf2 PRA1 domain family 2 0.33 NM_178249 Pramel6 Preferentially expressed antigen in melanoma like 6 0.45 NM_181650 Prdm4 PR domain containing 4 0.40 NM_025596 Prelid1 PRELI domain containing 1 0.34 NM_145984 Prepl Prolyl -like 0.43 NM_011174 Prh1 Proline rich protein HaeIII subfamily 1 0.40 NM_001039678 Prhoxnb Parahox cluster neighbor 0.42 NM_182997 Prkab2 Protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.29 NM_008925 Prkcsh Protein kinase C substrate 80K-H 0.37 NM_011159 Prkdc Protein kinase, DNA activated, catalytic polypeptide 0.38 NM_019830 Prmt1 Protein arginine N-methyltransferase 1 0.42 NM_013768 Prmt5 Protein arginine N-methyltransferase 5 0.43 NM_008936 Prop1 Paired like homeodomain factor 1 0.37 NM_001039077 Prosc Proline synthetase co-transcribed 0.37 NM_027328 Prpf31 PRP31 pre-mRNA processing factor 31 homolog (yeast) 0.34 NM_027297 Prpf4 PRP4 pre-mRNA processing factor 4 homolog (yeast) 0.41 NM_138659 Prpf8 Pre-mRNA processing factor 8 0.44 NM_001030296 Prr7 Proline rich 7 (synaptic) 0.33 NM_009430 Prss2 Protease, serine, 2 0.45 NM_011181 Pscd2 Pleckstrin homology, Sec7 and coiled-coil domains 2 0.27 NM_011965 Psma1 Proteasome (prosome, macropain) subunit, alpha type 1 0.37 NM_013640 Psmb10 Proteasome (prosome, macropain) subunit, beta type 10 0.27 NM_011970 Psmb2 Proteasome (prosome, macropain) subunit, beta type 2 0.41 NM_011874 Psmc4 Proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.35 NM_080554 Psmd5 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.42 NM_019455 Ptgds2 Prostaglandin D2 synthase 2, hematopoietic 0.42 NM_013641 Ptger1 Prostaglandin E receptor 1 (subtype EP1) 0.45 NM_022415 Ptges Prostaglandin E synthase 0.44 NM_008967 Ptgir Prostaglandin I receptor (IP) 0.33 NM_008970 Pthlh Parathyroid hormone-like peptide 0.44 NM_133949 Ptov1 Prostate tumor over expressed gene 1 0.21 Protein tyrosine phosphatase-like (proline instead of catalytic arginine), member NM_023587 Ptplb b 0.35 NM_178595 Ptrh1 Peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) 0.39 NM_145925 Pttg1ip Pituitary tumor-transforming 1 interacting protein 0.44 NM_021496 Pvrl3 Poliovirus receptor-related 3 0.41 NM_133794 Qars Glutaminyl-tRNA synthetase 0.37 NM_008999 Rab23 RAB23, member RAS oncogene family 0.44 NM_175562 Rab39 RAB39, member RAS oncogene family 0.22 NM_029391 Rab4b RAB4B, member RAS oncogene family 0.38 NM_025887 Rab5a RAB5A, member RAS oncogene family 0.44 NM_024287 Rab6 RAB6, member RAS oncogene family 0.37 NM_023126 Rab8a RAB8A, member RAS oncogene family 0.35 NM_145510 Rabif RAB interacting factor 0.43

121 NM_022327 Ralb V-ral simian leukemia viral oncogene homolog B (ras related) 0.38 NM_009067 Ralbp1 RalA binding protein 1 0.40 NM_023884 Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 0.42 NM_023130 Raly HnRNP-associated with lethal yellow 0.43 NM_177721 Ranbp6 RAN binding protein 6 0.43 NM_001039086 Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 0.28 NM_053268 Rasa2 RAS p21 protein activator 2 0.43 NM_178045 Rassf4 Ras association (RalGDS/AF-6) domain family 4 0.43 NM_175023 Rbbp6 Retinoblastoma binding protein 6 0.45 NM_153082 Rbj Rab and DnaJ domain containing 0.37 NM_028226 Rbm12b RNA binding motif protein 12B 0.39 NM_176838 Rbm35b RNA binding motif protein 35b 0.40 NM_009032 Rbm4 RNA binding motif protein 4 0.42 NM_025717 Rbm4b RNA binding motif protein 4B 0.37 NM_001039080 Rbms2 RNA binding motif, single stranded interacting protein 2 0.32 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.33 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.33 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.33 NM_011253 Rbmy1a1 RNA binding motif protein, Y chromosome, family 1, member A1 0.33 Regulator of chromosome condensation (RCC1) and BTB (POZ) domain NM_027764 Rcbtb1 containing protein 1 0.33 NM_173867 Rcc2 Regulator of chromosome condensation 2 0.40 NM_173445 Rccd1 RCC1 domain containing 1 0.40 NM_026557 Rchy1 Ring finger and CHY zinc finger domain containing 1 0.42 NM_009037 Rcn1 Reticulocalbin 1 0.41 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 0.32 NM_021557 Rdh11 Retinol dehydrogenase 11 0.43 NM_175372 Rdh13 Retinol dehydrogenase 13 (all-trans and 9-cis) 0.45 NM_023132 Renbp Renin binding protein 0.45 NM_181988 Rerg RAS-like, estrogen-regulated, growth-inhibitor 0.35 NM_178916 Rfesd Rieske (Fe-S) domain containing 0.37 NM_001007465 Rffl Ring finger and FYVE like domain containing protein 0.39 NM_178615 Rgmb RGM domain family, member B 0.36 NM_011267 Rgs16 Regulator of G-protein signaling 16 0.38 NM_177370 Rhbdd3 Rhomboid domain containing 3 0.41 NM_021375 Rhbg Rhesus blood group-associated B glycoprotein 0.45 NM_016802 Rhoa Ras homolog gene family, member A 0.43 NM_007483 Rhob Ras homolog gene family, member B 0.40 NM_007484 Rhoc Ras homolog gene family, member C 0.42 NM_133955 Rhou Ras homolog gene family, member U 0.44 NM_008955 Rhox6 Reproductive homeobox 6 0.34 NM_027897 Rhpn2 Rhophilin, Rho GTPase binding protein 2 0.36 NM_053194 Ric8 Resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.42 NM_011275 Rnaseh1 Ribonuclease H1 0.28 NM_027187 Rnaseh2a Ribonuclease H2, large subunit 0.38 NM_011883 Rnf13 Ring finger protein 13 0.45 NM_146042 Rnf144b Ring finger protein 144B 0.44 NM_026518 Rnf146 Ring finger protein 146 0.30 NM_027445 Rnf167 Ring finger protein 167 0.43 NM_153762 Rnf26 Ring finger protein 26 0.26 NM_172281 Rnf40 Ring finger protein 40 0.42 NM_001038696 Rnpc3 RNA-binding region (RNP1, RRM) containing 3 0.33 NM_009070 Rnps1 Ribonucleic acid binding protein S1 0.22 NM_146095 Rorb RAR-related orphan receptor beta 0.41 NM_001037916 RP23-233B9.8 Hypothetical protein LOC622665 0.32 NM_011284 Rpa2 Replication protein A2 0.33 NM_052835 Rpl10 Ribosomal protein 10 0.34 NM_009079 Rpl22 Ribosomal protein L22 0.26 NM_022891 Rpl23 Ribosomal protein L23 0.38

122 NM_024218 Rpl24 Ribosomal protein L24 0.45 NM_011975 Rpl27a Ribosomal protein L27a 0.45 NM_009084 Rpl37a Ribosomal protein L37a 0.30 NM_024212 Rpl4 Ribosomal protein L4 0.34 NM_025433 Rpl7l1 Ribosomal protein L7-like 1 0.40 NM_025938 Rpp14 Ribonuclease P 14 subunit (human) 0.40 NM_023133 Rps19 Ribosomal protein S19 0.30 NM_024266 Rps25 Ribosomal protein S25 0.40 NM_013765 Rps26 Ribosomal protein S26 0.37 NM_009093 Rps29 Ribosomal protein S29 0.39 NM_009096 Rps6 Ribosomal protein S6 0.42 NM_173450 Rpusd2 RNA pseudouridylate synthase domain containing 2 0.42 NM_199447 Rrp12 Ribosomal RNA processing 12 homolog (S. cerevisiae) 0.38 NM_026041 Rrp15 Ribosomal RNA processing 15 homolog (S. cerevisiae) 0.44 NM_025546 Rsl1d1 Ribosomal L1 domain containing 1 0.25 NM_009105 Rsu1 Ras suppressor protein 1 0.41 NM_130892 Rtn4ip1 Reticulon 4 interacting protein 1 0.45 NM_001008230 Rtp2 Receptor transporter protein 2 0.43 NM_175542 Rttn Rotatin 0.24 NM_001034060 Rufy4 RUN and FYVE domain containing 4 0.40 NM_199057 Rusc2 RUN and SH3 domain containing 2 0.23 NM_011305 Rxra alpha 0.41 NM_009113 S100a13 S100 calcium binding protein A13 0.44 NM_009115 S100b , beta polypeptide, neural 0.34 NM_172676 Samd10 Sterile alpha motif domain containing 10 0.25 NM_020483 Sap30bp SAP30 binding protein 0.39 NM_172205 Sbsn Suprabasin 0.44 NM_009130 Scg3 Secretogranin III 0.28 NM_009162 Scg5 Secretogranin V 0.45 NM_013928 Schip1 Schwannomin interacting protein 1 0.42 NM_001040026 Sco1 SCO cytochrome oxidase deficient homolog 1 (yeast) 0.42 NM_023912 Scyl1 SCY1-like 1 (S. cerevisiae) 0.41 NM_153125 Sec16a SEC16 homolog A (S. cerevisiae) 0.42 NM_172596 Sec24c SEC24 related gene family, member C (S. cerevisiae) 0.38 Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and NM_011976 Sema4g short cytoplasmic domain, (semaphorin) 4G 0.44 NM_029457 Senp2 SUMO/sentrin specific peptidase 2 0.45 NM_013759 Sepx1 Selenoprotein X 1 0.32 NM_011354 Serf2 Small EDRK-rich factor 2 0.38 NM_183197 Serpinb9f Serine (or cysteine) peptidase inhibitor, clade B, member 9f 0.43 NM_133210 Sertad3 SERTA domain containing 3 0.30 NM_144926 Sez6l2 Seizure related 6 homolog like 2 0.43 NM_011750 Sf1 Splicing factor 1 0.43 NM_175102 Sf3b5 Splicing factor 3b, subunit 5 0.33 NM_009159 Sfrs5 Splicing factor, arginine/serine-rich 5 (SRp40, HRS) 0.35 NM_009160 Sftpd Surfactant associated protein D 0.34 NM_011363 Sh2b1 SH2B adaptor protein 1 0.34 NM_012009 Sh2d1b1 SH2 domain protein 1B1 0.45 NM_019535 Sh3gl2 SH3-domain GRB2-like 2 0.43 NM_172788 Sh3md4 SH3 multiple domains 4 0.23 NM_007547 Sirpa Signal-regulatory protein alpha 0.22 NM_198014 Slain1 SLAIN motif family, member 1 0.40 NM_029084 Slamf8 SLAM family member 8 0.45 NM_145406 Slc10a3 Solute carrier family 10 (sodium/bile acid cotransporter family), member 3 0.44 NM_009195 Slc12a4 Solute carrier family 12, member 4 0.30 NM_020333 Slc12a5 Solute carrier family 12, member 5 0.45 NM_015747 Slc20a1 Solute carrier family 20, member 1 0.35 NM_008767 Slc22a18 Solute carrier family 22 (organic cation transporter), member 18 0.22 NM_011397 Slc23a1 Solute carrier family 23 (nucleobase transporters), member 1 0.43

123 NM_175034 Slc24a5 Solute carrier family 24, member 5 0.38 Solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), NM_013770 Slc25a10 member 10 0.32 Solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), NM_175194 Slc25a16 member 16 0.43 Solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), NM_011399 Slc25a17 member 17 0.34 Solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), NM_181328 Slc25a29 member 29 0.45 NM_028048 Slc25a35 Solute carrier family 25, member 35 0.43 NM_026165 Slc25a46 Solute carrier family 25, member 46 0.44 NM_021353 Slc26a3 Solute carrier family 26, member 3 0.21 NM_130451 Slc2a10 Solute carrier family 2 (facilitated glucose transporter), member 10 0.32 NM_009579 Slc30a1 Solute carrier family 30 (zinc transporter), member 1 0.34 NM_011773 Slc30a3 Solute carrier family 30 (zinc transporter), member 3 0.40 NM_015728 Slc33a1 Solute carrier family 33 (acetyl-CoA transporter), member 1 0.45 NM_011392 Slc34a1 Solute carrier family 34 (sodium phosphate), member 1 0.41 NM_016752 Slc35b1 Solute carrier family 35, member B1 0.45 NM_177766 Slc35e1 Solute carrier family 35, member E1 0.23 NM_153062 Slc37a1 Solute carrier family 37 (glycerol-3-phosphate transporter), member 1 0.41 NM_001039676 Slc39a2 Solute carrier family 39 (zinc transporter), member 2 0.40 NM_028051 Slc39a5 Solute carrier family 39 (metal ion transporter), member 5 0.45 Solute carrier family 3 (activators of dibasic and neutral amino acid transport), NM_008577 Slc3a2 member 2 0.41 NM_001037493 Slc41a3 Solute carrier family 41, member 3 0.43 NM_001039475 Slco6b1 Solute carrier organic anion transporter family, member 6b1 0.45 NM_008540 Smad4 MAD homolog 4 (Drosophila) 0.42 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, NM_011416 Smarca2 subfamily a, member 2 0.38 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, NM_007958 Smarcad1 subfamily a, containing DEAD/H box 1` 0.45 NM_008017 Smc2 Structural maintenance of chromosomes 2 0.24 NM_153808 Smc5 Structural maintenance of chromosomes 5 0.34 NM_134034 Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 0.36 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_207243 Smgc Submandibular gland protein C 0.37 NM_001038627 Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.35 NM_144918 Smyd5 SET and MYND domain containing 5 0.35 NM_133968 Snapc2 Small nuclear RNA activating complex, polypeptide 2 0.27 NM_183316 Snapc5 Small nuclear RNA activating complex, polypeptide 5 0.45 NM_033610 Sncb Synuclein, beta 0.42 NM_009223 Snn Stannin 0.41 NM_021335 Snrpb2 U2 small nuclear ribonucleoprotein B 0.40 NM_019727 Snx1 Sorting nexin 1 0.42 NM_172926 Snx14 Sorting nexin 14 0.32 NM_001025612 Snx22 Sorting nexin 22 0.35 NM_207213 Snx25 Sorting nexin 25 0.42 NM_011436 Sorl1 Sortilin-related receptor, LDLR class A repeats-containing 0.38 NM_011438 Sox12 SRY-box containing gene 12 0.41 NM_011441 Sox17 SRY-box containing gene 17 0.43 NM_173384 Sox30 SRY-box containing gene 30 0.44 NM_009238 Sox4 SRY-box containing gene 4 0.42 NM_013672 Sp1 Trans-acting transcription factor 1 0.34 NM_031183 Sp6 Trans-acting transcription factor 6 0.42

124 NM_172561 Spag7 Sperm associated antigen 7 0.37 NM_009242 Sparc Secreted acidic cysteine rich glycoprotein 0.28 NM_177867 Spata21 Spermatogenesis associated 21 0.38 NM_021343 Spata5 Spermatogenesis associated 5 0.36 NM_025565 Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.42 NM_025668 Spcs2 Signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.38 NM_029048 Spdyb Speedy homolog B (Drosophila) 0.45 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 0.36 NM_145584 Spon1 Spondin 1, (f-spondin) extracellular matrix protein 0.38 NM_013539 Spsb2 SplA/ryanodine receptor domain and SOCS box containing 2 0.33 NM_027141 Spsb3 SplA/ryanodine receptor domain and SOCS box containing 3 0.43 NM_011479 Sptlc2 Serine palmitoyltransferase, long chain base subunit 2 0.43 NM_020493 Srf 0.43 Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal NM_011481 Srms myristylation sites 0.40 NM_146032 Srp68 Signal recognition particle 68 0.43 NM_026130 Srpr Signal recognition particle receptor ('docking protein') 0.36 NM_016911 Srpx Sushi-repeat-containing protein 0.43 NM_024272 Ssbp2 Single-stranded DNA binding protein 2 0.37 NM_009178 St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.39 NM_001035228 St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.44 NM_172829 St6gal2 Beta galactoside alpha 2,6 sialyltransferase 2 0.29 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N- NM_012028 St6galnac5 acetylgalactosaminide alpha-2,6-sialyltransferase 5 0.40 NM_153091 St7l Suppression of tumorigenicity 7-like 0.33 NM_009181 St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.37 NM_009283 Stat1 Signal transducer and activator of transcription 1 0.45 NM_011488 Stat5a Signal transducer and activator of transcription 5A 0.45 NM_025303 Stau2 Staufen (RNA binding protein) homolog 2 (Drosophila) 0.42 NM_011494 Stk16 Serine/threonine kinase 16 0.44 NM_019641 Stmn1 1 0.43 NM_009291 Stra6 Stimulated by retinoic acid gene 6 0.41 NM_019719 Stub1 STIP1 homology and U-Box containing protein 1 0.40 NM_011502 Stx3 0.33 NM_019829 Stx5a Syntaxin 5A 0.38 NM_011507 Suclg2 Succinate-Coenzyme A ligase, GDP-forming, beta subunit 0.44 NM_020564 Sult5a1 Sulfotransferase family 5A, member 1 0.43 NM_178652 Supt3h Suppressor of Ty 3 homolog (S. cerevisiae) 0.30 NM_013678 Surf2 Surfeit gene 2 0.41 NM_144871 Suv420h1 Suppressor of variegation 4-20 homolog 1 (Drosophila) 0.40 NM_146177 Suv420h2 Suppressor of variegation 4-20 homolog 2 (Drosophila) 0.26 NM_178046 Svil Supervillin 0.29 NM_011522 Syngr3 Synaptogyrin 3 0.42 NM_183368 Sytl3 Synaptotagmin-like 3 0.44 NM_001040435 Tacc3 Transforming, acidic coiled-coil containing protein 3 0.45 NM_020024 Taf10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.41 NM_022015 Taf8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq 0.41 NM_145968 Tagap T-cell activation Rho GTPase-activating protein 0.42 NM_013683 Tap1 Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.45 NM_033074 Tars Threonyl-tRNA synthetase 0.44 NM_181516 Taz Tafazzin 0.41 NM_178385 Tbcc Tubulin-specific chaperone c 0.37 NM_013763 Tbl2 Transducin (beta)-like 2 0.44 NM_145396 Tbl3 Transducin (beta)-like 3 0.44 NM_029467 Tcam1 Testicular cell adhesion molecule 1 0.42 NM_146236 Tceal1 Transcription elongation factor A (SII)-like 1 0.45 NM_026456 Tceb1 Transcription elongation factor B (SIII), polypeptide 1 0.35 NM_011547 Tcfap2a Transcription factor AP-2, alpha 0.32 NM_013773 Tcl1b1 T-cell leukemia/lymphoma 1B, 1 0.43

125 NM_011553 Tcp10b T-complex protein 10b 0.40 NM_031387 Tdrd1 Tudor domain containing 1 0.45 NM_009348 Tectb Tectorin beta 0.42 NM_019643 Tera Teratocarcinoma expressed, serine rich 0.31 NM_020584 Terf2ip Telomeric repeat binding factor 2, interacting protein 0.44 NM_019981 Tex101 Testis expressed gene 101 0.38 NM_011573 Tex264 Testis expressed gene 264 0.43 NM_009359 Tex9 Testis expressed gene 9 0.42 NM_031199 Tgfa Transforming growth factor alpha 0.40 NM_009365 Tgfb1i1 Transforming growth factor beta 1 induced transcript 1 0.44 NM_009374 Tgm3 Transglutaminase 3, E polypeptide 0.33 NM_177726 Tgm6 Transglutaminase 6 0.43 NM_009444 Tgoln1 Trans-golgi network protein 0.38 NM_199042 Thap1 THAP domain containing, apoptosis associated protein 1 0.36 NM_153552 Thoc1 THO complex 1 0.37 NM_178646 Tigd5 Tigger transposable element derived 5 0.42 NM_013895 Timm13 Translocase of inner mitochondrial membrane 13 homolog (yeast) 0.43 NM_011592 Timm44 Translocase of inner mitochondrial membrane 44 0.34 NM_013897 Timm8b Translocase of inner mitochondrial membrane 8 homolog b (yeast) 0.35 NM_011595 Timp3 Tissue inhibitor of metalloproteinase 3 0.42 NM_031178 Tlr9 Toll-like receptor 9 0.45 NM_172310 Tm2d3 TM2 domain containing 3 0.43 NM_145539 Tm4sf4 Transmembrane 4 superfamily member 4 0.44 NM_028454 Tm7sf2 Transmembrane 7 superfamily member 2 0.45 NM_019770 Tmed2 Transmembrane emp24 domain trafficking protein 2 0.43 NM_025458 Tmed6 Transmembrane emp24 protein transport domain containing 6 0.39 NM_026433 Tmem100 Transmembrane protein 100 0.38 NM_029649 Tmem101 Transmembrane protein 101 0.37 NM_001033393 Tmem104 Transmembrane protein 104 0.35 NM_144830 Tmem106a Transmembrane protein 106A 0.27 NM_173453 Tmem11 Transmembrane protein 11 0.39 NM_175145 Tmem127 Transmembrane protein 127 0.22 NM_028343 Tmem135 Transmembrane protein 135 0.31 NM_029398 Tmem14a Transmembrane protein 14A 0.43 NM_025387 Tmem14c Transmembrane protein 14C 0.35 NM_001002267 Tmem158 Transmembrane protein 158 0.40 NM_178773 Tmem16d Transmembrane protein 16D (eight membrane-spanning domains) 0.45 NM_027909 Tmem24 Transmembrane protein 24 0.40 NM_028975 Tmem33 Transmembrane protein 33 0.37 NM_144534 Tmem38a Transmembrane protein 38A 0.22 NM_025339 Tmem42 Transmembrane protein 42 0.45 NM_028766 Tmem43 Transmembrane protein 43 0.31 NM_001033271 Tmem55b Transmembrane protein 55b 0.40 NM_144794 Tmem63a Transmembrane protein 63a 0.45 NM_177670 Tmem69 Transmembrane protein 69 0.35 NM_133706 Tmem97 Transmembrane protein 97 0.39 NM_016711 Tmod2 0.39 NM_172455 Tmprss7 Transmembrane serine protease 7 0.38 NM_009397 Tnfaip3 Tumor necrosis factor, alpha-induced protein 3 0.39 NM_177371 Tnfsf15 Tumor necrosis factor (ligand) superfamily, member 15 0.45 NM_009404 Tnfsf9 Tumor necrosis factor (ligand) superfamily, member 9 0.40 NM_139064 Tnip2 TNFAIP3 interacting protein 2 0.35 NM_016788 Tnk2 Tyrosine kinase, non-receptor, 2 0.25 NM_144812 Tnrc6b Trinucleotide repeat containing 6b 0.44 NM_026654 Toe1 Target of EGR1, member 1 (nuclear) 0.39 NM_172609 Tomm22 Translocase of outer mitochondrial membrane 22 homolog (yeast) 0.45 NM_016871 Tomm40 Translocase of outer mitochondrial membrane 40 homolog (yeast) 0.32 NM_134097 Topors Topoisomerase I binding, arginine/serine-rich 0.43

126 NM_001025263 Tpd52 Tumor protein D52 0.44 NM_009418 Tpp2 II 0.39 NM_026508 Trap1 TNF receptor-associated protein 1 0.43 NM_001024206 Trappc1 Trafficking protein particle complex 1 0.26 NM_001012236 Trex1 Three prime repair exonuclease 1 0.29 NM_144551 Trib2 Tribbles homolog 2 (Drosophila) 0.40 NM_001025599 Trim26 Tripartite motif protein 26 0.45 NM_053170 Trim33 Tripartite motif protein 33 0.25 NM_029979 Trim35 Tripartite motif-containing 35 0.42 NM_201373 Trim56 Tripartite motif-containing 56 0.45 NM_025863 Trim59 Tripartite motif-containing 59 0.39 NM_198012 Trim68 Tripartite motif containing 68 0.38 NM_026642 Trmt12 TRNA methyltranferase 12 homolog (S. cerevisiae) 0.32 NM_178111 Trp53inp2 Transformation related protein 53 inducible nuclear protein 2 0.36 NM_024168 Tsen34 TRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae) 0.43 NM_025982 Tspan31 Tetraspanin 31 0.45 NM_019634 Tspan7 Tetraspanin 7 0.28 NM_020285 Tssc4 Tumor-suppressing subchromosomal transferable fragment 4 0.36 NM_133795 Ttc1 Tetratricopeptide repeat domain 1 0.33 NM_028209 Ttc4 Tetratricopeptide repeat domain 4 0.44 NM_172799 Ttll6 Tubulin tyrosine ligase-like family, member 6 0.40 NM_021324 Ttyh1 Tweety homolog 1 (Drosophila) 0.45 NM_175274 Ttyh3 Tweety homolog 3 (Drosophila) 0.41 NM_011654 Tuba1b Tubulin, alpha 1B 0.39 NM_009449 Tuba3b Tubulin, alpha 3B 0.45 NM_009450 Tubb2a Tubulin, beta 2a 0.29 NM_134024 Tubg1 Tubulin, gamma 1 0.41 NM_198031 Tubgcp3 Tubulin, gamma complex associated protein 3 0.38 NM_019742 Tusc2 Tumor suppressor candidate 2 0.36 NM_018879 Tusc4 Tumor suppressor candidate 4 0.29 NM_197993 Tut1 Terminal uridylyl transferase 1, U6 snRNA-specific 0.40 NM_019913 Txn2 Thioredoxin 2 0.44 NM_145367 Txndc5 Thioredoxin domain containing 5 0.42 NM_015762 Txnrd1 Thioredoxin reductase 1 0.39 NM_028283 Uaca Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.38 NM_011664 Ubb Ubiquitin B 0.33 NM_172712 Ube1l2 Ubiquitin-activating enzyme E1-like 2 0.45 NM_026785 Ube2c Ubiquitin-conjugating enzyme E2C 0.28 NM_026454 Ube2f Ubiquitin-conjugating enzyme E2F (putative) 0.43 NM_026390 Ubxd2 UBX domain containing 2 0.36 NM_025352 Uqcrq Ubiquinol-cytochrome c reductase, complex III subunit VII 0.43 NM_026615 Urm1 Ubiquitin related modifier 1 homolog (S. cerevisiae) 0.37 NM_025917 Use1 RIKEN cDNA 2010315L10 gene 0.41 NM_146144 Usp1 Ubiquitin specific peptdiase 1 0.44 NM_024258 Usp16 Ubiquitin specific peptidase 16 0.25 NM_144937 Usp3 Ubiquitin specific peptidase 3 0.45 NM_133992 Usp52 Ubiquitin specific peptidase 52 0.41 NM_030180 Usp54 Ubiquitin specific peptidase 54 0.39 NM_019729 Usp8 Ubiquitin specific peptidase 8 0.36 NM_178635 Uvrag UV radiation resistance associated gene 0.40 NM_013840 Uxt Ubiquitously expressed transcript 0.44 NM_134220 V1ri3 Vomeronasal 1 receptor, I3 0.40 NM_134226 V1rj2 Vomeronasal 1 receptor, J2 0.36 NM_009496 Vamp1 Vesicle-associated membrane protein 1 0.43 NM_139307 Vasn Vasorin 0.30 NM_173443 Vcpip1 Valosin containing protein (p97)/p47 complex interacting protein 1 0.43 NM_145820 Veph1 Ventricular zone expressed PH domain homolog 1 (zebrafish) 0.32 NM_177683 Vgll4 Vestigial like 4 (Drosophila) 0.45

127 NM_009511 Vipr2 Vasoactive intestinal peptide receptor 2 0.40 NM_178600 Vkorc1 epoxide reductase complex, subunit 1 0.32 NM_001013607 Vmo1 Vitelline membrane outer layer 1 homolog (chicken) 0.43 NM_172269 Vps18 Vacuolar protein sorting 18 (yeast) 0.38 NM_133945 Vrk3 Vaccinia related kinase 3 0.44 NM_011710 Wars Tryptophanyl-tRNA synthetase 0.33 NM_029274 Wbp7 WW domain binding protein 7 0.37 NM_153167 Wdr32 WD repeat domain 32 0.37 NM_172470 Wdr35 WD repeat domain 35 0.42 NM_172445 Wdr37 WD repeat domain 37 0.35 NM_029687 Wdr38 WD repeat domain 38 0.42 NM_178739 Wdr40b WD repeat domain 40B 0.36 NM_020603 Wdr46 WD repeat domain 46 0.32 NM_176923 Wdr59 WD repeat domain 59 0.39 NM_001025375 Wdr61 WD repeat domain 61 0.28 NM_027946 Wdr68 WD repeat domain 68 0.38 NM_178909 Wdr92 WD repeat domain 92 0.44 NM_153138 Wipf1 WAS/WASL interacting protein family, member 1 0.33 NM_009523 Wnt4 Wingless-related MMTV integration site 4 0.34 NM_019653 Wsb1 WD repeat and SOCS box-containing 1 0.43 NM_026156 Xab2 XPA binding protein 2 0.39 NM_011723 Xdh Xanthine dehydrogenase 0.43 NM_177310 Xpnpep3 X-prolyl aminopeptidase (aminopeptidase P) 3, putative 0.24 NM_028198 Xpo5 Exportin 5 0.42 NM_020570 Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.43 NM_134151 Yars Tyrosyl-tRNA synthetase 0.44 NM_016875 Ybx2 Y box protein 2 0.38 NM_001005342 Ypel4 Yippee-like 4 (Drosophila) 0.24 NM_001033466 Zbtb2 Zinc finger and BTB domain containing 2 0.34 NM_172643 Zbtb41 Zinc finger and BTB domain containing 41 homolog 0.45 NM_001024699 ZBTB45 Zinc finger and BTB domain containing 45 0.45 NM_026083 Zc3h13 Zinc finger CCCH type containing 13 0.43 NM_172121 Zc3h3 Zinc finger CCCH type containing 3 0.38 NM_145931 Zc3h7a Zinc finger CCCH type containing 7 A 0.42 NM_172735 Zc3hc1 Zinc finger, C3HC type 1 0.43 NM_153160 Zcchc17 Zinc finger, CCHC domain containing 17 0.45 NM_177027 Zcchc7 Zinc finger, CCHC domain containing 7 0.28 NM_028379 Zdhhc4 Zinc finger, DHHC domain containing 4 0.42 NM_178694 Zer1 Zer-1 homolog (C. elegans) 0.44 NM_133349 Zfand2a Zinc finger, AN1-type domain 2A 0.41 NM_026846 Zfand2b Zinc finger, AN1 type domain 2B 0.35 NM_009281 Zfp143 Zinc finger protein 143 0.35 NM_145547 Zfp189 Zinc finger protein 189 0.23 NM_028335 Zfp248 Zinc finger protein 248 0.42 NM_148924 Zfp263 Zinc finger protein 263 0.40 NM_198322 Zfp273 Zinc finger protein 273 0.40 NM_020497 Zfp276 Zinc finger protein (C2H2 type) 276 0.42 NM_175247 Zfp28 Zinc finger protein 28 0.35 NM_030743 Zfp313 Zinc finger protein 313 0.25 NM_178732 Zfp324 Zinc finger protein 324 0.30 NM_146221 Zfp426 Zinc finger protein 426 0.42 NM_133817 Zfp451 Zinc finger protein 451 0.42 NM_172794 Zfp454 Zinc finger protein 454 0.36 NM_001001186 Zfp456 Zinc finger protein 456 0.42 NM_009558 Zfp51 Zinc finger protein 51 0.40 NM_172617 Zfp523 Zinc finger protein 523 0.40 NM_175477 Zfp574 Zinc finger protein 574 0.35 NM_024215 Zfp593 Zinc finger protein 593 0.26

128 NM_144523 Zfp622 Zinc finger protein 622 0.28 NM_170759 Zfp628 Zinc finger protein 628 0.34 NM_028141 Zfp661 Zinc finger protein 661 0.42 NM_030074 Zfp687 Zinc finger protein 687 0.36 NM_001005788 Zfp69 Zinc finger protein 69 0.44 NM_145916 Zfp7 Zinc finger protein 7 0.44 NM_175466 Zfp770 Zinc finger protein 770 0.45 NM_028913 Zfp819 Zinc finger protein 819 0.43 NM_001039718 Zfp91 Zinc finger protein 91 0.45 NM_011769 Zim1 Zinc finger, imprinted 1 0.38 NM_172503 Zswim4 Zinc finger, SWIM domain containing 4 0.41 NM_011777 Zyx Zyxin 0.37 NM_001002771 0.43 NM_001002795 0.41 NM_001004437 0.37 NM_001013754 0.43 NM_001033377 0.43 NM_001033814 0.32 NM_001037717 0.36 NM_001037921 0.41 NM_001039232 0.41 NM_001040398 0.35 NM_018745 0.44 NM_025472 0.36 NM_026287 0.42 NM_026297 0.22 NM_026916 0.39 NM_027681 0.45 NM_028045 0.44 NM_028793 0.24 NM_029952 0.35 NM_153199 0.39 NM_172270 0.21 NM_172408 0.39 NM_175322 0.44 NM_175354 0.21 NM_176925 0.37 NM_177065 0.30 NM_177210 0.44 NM_177615 0.36 NM_177729 0.41 NM_178391 0.39 NM_183110 0.45 NM_183215 0.45 NM_183283 0.45 NM_198646 0.41 NM_198646 0.41

SUPPLEMENTAL TABLE S10: Genes Demonstrating Increased Phospho-CREB Binding in the Social Isolation Model (p<0.001)

Accession Number Symbol Name Fold Change NM_053102 15-Sep Selenoprotein 2.48 NM_026757 0610010K14Rik RIKEN cDNA 0610010K14 gene 2.66 NM_026686 0610011F06Rik RIKEN cDNA 0610011F06 gene 2.90 NM_026714 0610037D15Rik RIKEN cDNA 0610037D15 gene 4.07 NM_133697 1110003E01Rik RIKEN cDNA 1110003E01 gene 2.60 NM_025364 1110005A23Rik RIKEN cDNA 1110005A23 gene 3.79 NM_026789 1110020C03Rik RIKEN cDNA 1110020C03 gene 3.01

129 NM_026807 1110033F04Rik RIKEN cDNA 1110033F04 gene 2.80 NM_172401 1110057K04Rik RIKEN cDNA 1110057K04 gene 3.29 NM_026503 1110058L19Rik RIKEN cDNA 1110058L19 gene 3.25 NM_001033874 1190002A17Rik RIKEN cDNA 1190002A17 gene 2.46 NM_181274 1200003I07Rik RIKEN cDNA 1200003I07 gene 2.49 NM_028773 1200013B08Rik RIKEN cDNA 1200013B08 gene 3.80 NM_019769 1500003O03Rik RIKEN cDNA 1500003O03 gene 4.10 NM_024172 1500019G21Rik RIKEN cDNA 1500019G21 gene 2.67 NM_026451 1600012H06Rik RIKEN cDNA 1600012H06 gene 2.97 NM_029602 1700022C21Rik RIKEN cDNA 1700022C21 gene 2.45 NM_001033184 1700057G04Rik RIKEN cDNA 1700057G04 gene 2.68 NM_028550 1700074P13Rik RIKEN cDNA 1700074P13 gene 3.92 NM_021437 1700123O20Rik RIKEN cDNA 1700123O20 gene 2.73 NM_025463 1810009A15Rik RIKEN cDNA 1810009A15 gene 2.91 NM_025464 1810021J13Rik RIKEN cDNA 1810021J13 gene 3.02 NM_026958 1810035L17Rik RIKEN cDNA 1810035L17 gene 3.14 NM_026327 1810048J11Rik RIKEN cDNA 1810048J11 gene 2.97 NM_001003405 1810049H19Rik RIKEN cDNA 1810049H19 gene 2.42 NM_174987 1810063B05Rik RIKEN cDNA 1810063B05 gene 2.96 NM_177674 2010015L04Rik RIKEN cDNA 2010015L04 gene 2.72 NM_026198 2010200O16Rik RIKEN cDNA 2010200O16 gene 2.79 NM_001033165 2010203O07Rik RIKEN cDNA 2010203O07 gene 2.52 NM_027990 2310010M24Rik RIKEN cDNA 2310010M24 gene 2.45 NM_025865 2310030G06Rik RIKEN cDNA 2310030G06 gene 2.45 NM_025542 2410001C21Rik RIKEN cDNA 2410001C21 gene 5.66 NM_029354 2410018G20Rik RIKEN cDNA 2410018G20 gene 2.40 NM_029841 2510039O18Rik RIKEN cDNA 2510039O18 gene 3.03 NM_028129 2610020H08Rik RIKEN cDNA 2610020H08 gene 2.62 NM_028228 2610028A01Rik RIKEN cDNA 2610028A01 gene 3.30 NM_170592 2610205E22Rik RIKEN cDNA 2610205E22 gene 2.77 NM_175382 2700049P18Rik RIKEN cDNA 2700049P18 gene 2.42 NM_026528 2700060E02Rik RIKEN cDNA 2700060E02 gene 2.81 NM_173382 2810046L04Rik RIKEN cDNA 2810046L04 gene 2.51 NM_025582 2810405K02Rik RIKEN cDNA 2810405K02 gene 2.42 NM_025581 2810433K01Rik RIKEN cDNA 2810433K01 gene 2.68 NM_176836 2810485I05Rik RIKEN cDNA 2810485I05 gene 3.34 NM_133749 2900064A13Rik RIKEN cDNA 2900064A13 gene 2.38 NM_133693 3100004P22Rik RIKEN cDNA 3100004P22 gene 2.49 NM_199145 3110062M04Rik RIKEN cDNA 3110062M04 gene 2.54 NM_025699 3230401D17Rik RIKEN cDNA 3230401D17 gene 2.97 NM_207281 4832428D23Rik RIKEN cDNA 4832428D23 gene 2.65 NM_027600 4921504E06Rik RIKEN cDNA 4921504E06 gene 2.40 NM_175517 4930412F15Rik RIKEN cDNA 4930412F15 gene 2.63 NM_028672 4930430E16Rik RIKEN cDNA 4930430E16 gene 2.37 NM_029199 4930542N07Rik RIKEN cDNA 4930542N07 gene 3.18 NM_144535 4932432K03Rik RIKEN cDNA 4932432K03 gene 3.36 NM_001039488 4933421E11Rik RIKEN cDNA 4933421E11 gene 3.99 NM_175674 4933425M15Rik RIKEN cDNA 4933425M15 gene 2.77 NM_177607 4933430I17Rik RIKEN cDNA 4933430I17 gene 2.63 NM_028964 4933437K13Rik RIKEN cDNA 4933437K13 gene 2.76 NM_194335 4933440H19Rik RIKEN cDNA 4933440H19 gene 3.27 NM_025679 5730470L24Rik RIKEN cDNA 5730470L24 gene 2.48 NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene 2.43 NM_175110 5730577I03Rik RIKEN cDNA 5730577I03 gene 3.88 NM_172543 5730593F17Rik RIKEN cDNA 5730593F17 gene 5.47 NM_026368 5830433M19Rik RIKEN cDNA 5830433M19 gene 3.29 NM_029528 6330503C03Rik RIKEN cDNA 6330503C03 gene 3.33 NM_207583 6430517E21Rik RIKEN cDNA 6430517E21 gene 2.84

130 NM_145836 6430527G18Rik RIKEN cDNA 6430527G18 gene 2.76 NM_175398 6530418L21Rik RIKEN cDNA 6530418L21 gene 2.81 NM_172600 6720456H20Rik RIKEN cDNA 6720456H20 gene 2.88 NM_178670 8030462N17Rik RIKEN cDNA 8030462N17 gene 3.72 NM_001039552 9030025P20Rik RIKEN cDNA 9030025P20 gene 2.82 NM_172458 9030612M13Rik RIKEN cDNA 9030612M13 gene 4.45 NM_023865 9530002B09Rik RIKEN cDNA 9530002B09 gene 2.75 NM_153117 9530068E07Rik RIKEN cDNA 9530068E07 gene 2.51 NM_177159 9530091C08Rik RIKEN cDNA 9530091C08 gene 2.53 NM_177573 9930104L06Rik RIKEN cDNA 9930104L06 gene 2.43 NM_177194 A130023I24Rik RIKEN cDNA A130023I24 gene 2.84 NM_001033375 A230046K03Rik RIKEN cDNA A230046K03 gene 2.63 NM_183188 A2bp1 Ataxin 2 binding protein 1 2.70 NM_029972 A330104H05Rik RIKEN cDNA A330104H05 gene 2.37 NM_177358 A630033E08Rik RIKEN cDNA A630033E08 gene 3.06 NM_176956 A730018C14Rik RIKEN cDNA A730018C14 gene 2.38 NM_146115 A830007P12Rik RIKEN cDNA A830007P12 gene 2.51 NM_177173 A830018L16Rik RIKEN cDNA A830018L16 gene 2.95 NM_001033208 AA407270 Expressed sequence AA407270 2.77 NM_001024512 AA536717 Expressed sequence AA536717 2.68 NM_013930 Aass Aminoadipate-semialdehyde synthase 2.75 NM_019816 Aatf Apoptosis antagonizing transcription factor 3.46 NM_007378 Abca4 ATP-binding cassette, sub-family A (ABC1), member 4 2.48 NM_013853 Abcf2 ATP-binding cassette, sub-family F (GCN20), member 2 3.19 NM_009596 Abpa Androgen binding protein alpha 2.47 NM_017366 Acadvl Acyl-Coenzyme A dehydrogenase, very long chain 2.53 NM_025988 Acbd4 Acyl-Coenzyme A binding domain containing 4 2.45 NM_080633 Aco2 Aconitase 2, mitochondrial 3.21 NM_007392 Acta2 Actin, alpha 2, , aorta 3.62 NM_025914 Actr6 ARP6 actin-related protein 6 homolog (yeast) 2.49 A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin NM_175506 Adamts19 type 1 motif, 19 2.39 NM_001038587 Adar Adenosine deaminase, RNA-specific 2.95 NM_007409 Adh1 Alcohol dehydrogenase 1 (class I) 2.66 1-acylglycerol-3-phosphate O-acyltransferase 1 ( NM_018862 Agpat1 acyltransferase, alpha) 2.56 NM_013464 Ahr Aryl-hydrocarbon receptor 2.47 NM_001033199 AI747448 Expressed sequence AI747448 2.82 NM_183167 AI987944 Expressed sequence AI987944 2.45 NM_001033966 Ak2 Adenylate kinase 2 2.45 NM_009650 Akap3 A kinase (PRKA) anchor protein 3 2.52 NM_019774 Akap8 A kinase (PRKA) anchor protein 8 2.44 NM_054080 Akr1c20 Aldo-keto reductase family 1, member C20 2.41 NM_026270 Akt1s1 AKT1 substrate 1 (proline-rich) 2.70 NM_009655 Alcam Activated leukocyte cell adhesion molecule 2.38 NM_009662 Alox5 Arachidonate 5-lipoxygenase 2.58 NM_028717 Als2 Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) 3.31 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 2.97 NM_009664 Ambn Ameloblastin 3.67 NM_001005421 Amica1 Adhesion molecule, interacts with CXADR antigen 1 2.73 NM_033603 Amn Amnionless 4.33 NM_007426 Angpt2 Angiopoietin 2 2.63 NM_170728 Ank3 Ankyrin 3, epithelial 3.00 NM_023472 Ankra2 Ankyrin repeat, family A (RFXANK-like), 2 2.78 NM_001013806 Ankrd13c Ankyrin repeat domain 13c 3.45 NM_177268 Ankrd16 Ankyrin repeat domain 16 2.37 NM_019683 Ankrd49 Ankyrin repeat domain 49 3.28 NM_029245 Ankrd53 Ankyrin repeat domain 53 3.00 NM_009675 Aoc3 Amine oxidase, copper containing 3 2.42

131 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 2.54 NM_011318 Apcs Serum amyloid P-component 2.73 NM_009687 Apex1 Apurinic/apyrimidinic endonuclease 1 2.57 NM_009698 Aprt Adenine phosphoribosyl transferase 3.27 NM_009702 Aqr Aquarius 4.39 NM_133796 Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 2.44 NM_001033329 Arhgef9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.40 NM_019419 Arl6ip1 ADP-ribosylation factor-like 6 interacting protein 1 3.22 NM_028768 Armc8 Armadillo repeat containing 8 4.10 NM_133205 Arr3 Arrestin 3, retinal 3.58 NM_025549 Arrdc4 Arrestin domain containing 4 2.76 NM_031405 Ars2 Arsenate resistance protein 2 2.64 NM_029847 Arsk Arylsulfatase K 2.88 NM_020051 Ascl3 Achaete-scute complex homolog-like 3 (Drosophila) 2.43 NM_133768 Asl Argininosuccinate lyase 2.42 NM_025651 Aste1 Asteroid homolog 1 (Drosophila) 2.87 NM_019514 Astn2 Astrotactin 2 3.27 NM_026487 Atad1 ATPase family, AAA domain containing 1 2.70 NM_009716 Atf4 Activating transcription factor 4 3.33 NM_009728 Atp10a ATPase, class V, type 10A 2.88 NM_011596 Atp6v0a2 ATPase, H+ transporting, lysosomal V0 subunit A2 3.36 NM_025494 Atp6v1c1 3.41 NM_145425 AV249152 Expressed sequence AV249152 2.44 NM_146168 AW146242 Expressed sequence AW146242 2.79 NM_001039824 B230118G17Rik RIKEN cDNA B230118G17 gene 2.83 NM_178084 B230120H23Rik RIKEN cDNA B230120H23 gene 2.48 NM_009735 B2m Beta-2 microglobulin 2.38 NM_153539 B830045N13Rik RIKEN cDNA B830045N13 gene 2.37 NM_172148 B9d2 B9 protein domain 2 2.80 NM_027088 Bap1 Brca1 associated protein 1 2.79 NM_020027 Bat2 HLA-B associated transcript 2 2.45 NM_181316 Bbs9 Bardet-Biedl syndrome 9 2.42 NM_030252 BC003266 CDNA sequence BC003266 2.56 NM_145591 BC003267 CDNA sequence BC003267 3.09 NM_145511 BC003331 CDNA sequence BC003331 2.49 NM_030560 BC003993 CDNA sequence BC003993 2.87 NM_024473 BC005537 CDNA sequence BC005537 2.98 NM_144885 BC005624 CDNA sequence BC005624 2.40 NM_145389 BC016579 CDNA sequence, BC016579 4.06 NM_144890 BC018465 CDNA sequence BC018465 2.79 NM_153576 BC024561 CDNA sequence BC024561 3.08 NM_145972 BC027231 CDNA sequence BC027231 2.85 NM_173738 BC027344 CDNA sequence BC027344 4.34 NM_001003939 BC030307 CDNA sequence BC030307 2.85 NM_145943 BC031781 CDNA sequence BC031781 2.78 NM_177878 BC038925 CDNA sequence BC038925 2.56 NM_174848 BC043118 CDNA sequence BC043118 2.77 NM_175020 BC048599 CDNA sequence BC048599 4.04 NM_183143 BC048679 CDNA sequence BC048679 3.27 NM_183181 BC050777 CDNA sequence BC050777 2.59 NM_198631 BC057627 CDNA sequence BC057627 6.87 NM_007530 Bcap29 B-cell receptor-associated protein 29 2.89 NM_013867 Bcar3 Breast cancer anti-estrogen resistance 3 2.73 NM_025784 Bcs1l BCS1-like (yeast) 2.46 NM_026975 Bola1 BolA-like 1 (E. coli) 2.68 Biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated NM_026512 Bphl antigen) 2.70 NM_177850 Bpi Bactericidal permeablility increasing protein 3.94 NM_009764 Brca1 Breast cancer 1 11.65

132 NM_009765 Brca2 Breast cancer 2 3.22 NM_001037756 Brms1l Breast cancer metastasis-suppressor 1-like 3.19 NM_178245 Bsx Brain specific homeobox 2.59 NM_175938 Btn2a2 Butyrophilin, subfamily 2, member A2 2.89 NM_001008705 Bud31 BUD31 homolog (yeast) 2.53 NM_011795 C1ql1 Complement component 1, q subcomponent-like 1 3.92 NM_030888 C1qtnf3 C1q and tumor necrosis factor related protein 3 2.81 NM_007576 C4bp Complement component 4 binding protein 3.26 NM_175696 C530028O21Rik RIKEN cDNA C530028O21 gene 2.62 NM_146067 C530044N13Rik RIKEN cDNA C530044N13 gene 2.56 NM_178879 C76566 Expressed sequence C76566 3.68 NM_146170 C87436 Expressed sequence C87436 2.77 NM_013877 Cabp5 Calcium binding protein 5 3.41 NM_027687 Cabyr Calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2) 2.53 NM_007590 Calm3 Calmodulin 3 3.10 NM_007596 Caml Calcium modulating ligand 2.56 NM_007604 Capza2 Capping protein (actin filament) muscle Z-line, alpha 2 3.54 NM_181315 Car5b Carbonic anhydrase 5b, mitochondrial 3.88 NM_175362 Card11 Caspase recruitment domain family, member 11 3.45 NM_007610 Casp2 Caspase 2 3.45 NM_009811 Casp6 Caspase 6 2.69 NM_007611 Casp7 Caspase 7 3.27 NM_007620 Cbr1 Carbonyl reductase 1 2.92 NM_145595 Cbr4 Carbonyl reductase 4 3.66 NM_146097 Cbwd1 COBW domain containing 1 4.00 NM_173763 Ccbl2 Cysteine conjugate-beta lyase 2 4.16 NM_001033784 Ccdc13 Coiled-coil domain containing 13 3.48 NM_172428 Ccdc134 Coiled-coil domain containing 134 3.37 NM_026222 Ccdc39 Coiled-coil domain containing 39 2.85 NM_029606 Ccdc46 Coiled-coil domain containing 46 2.96 NM_026186 Ccdc49 Coiled-coil domain containing 49 4.02 NM_029061 Ccdc7 Coiled-coil domain containing 7 2.38 NM_026028 Ccdc77 Coiled-coil domain containing 77 3.27 NM_198616 Ccdc85b Coiled-coil domain containing 85B 2.79 NM_023731 Ccdc86 Coiled-coil domain containing 86 3.36 NM_025515 Ccdc90b Coiled-coil domain containing 90B 2.48 NM_009827 Cckar Cholecystokinin A receptor 2.85 NM_007632 Ccnd3 Cyclin D3 2.38 NM_172839 Ccnj Cyclin J 3.27 NM_009832 Ccnk Cyclin K 2.54 NM_207678 Ccnl2 Cyclin L2 7.15 NM_009833 Ccnt1 Cyclin T1 2.52 NM_021325 Cd200r1 CD200 receptor 1 3.06 NM_199221 Cd300lb CD300 antigen like family member B 4.14 NM_013489 Cd84 CD84 antigen 3.34 NM_007661 Cdc2l1 Cell division cycle 2-like 1 3.00 NM_025950 Cdc37l1 Cell division cycle 37 homolog (S. cerevisiae)-like 1 3.77 NM_172395 Cdc42se1 CDC42 small effector 1 3.35 NM_009871 Cdk5r1 Cyclin-dependent kinase 5, regulatory subunit (p35) 1 2.37 NM_009876 Cdkn1c Cyclin-dependent kinase inhibitor 1C (P57) 2.48 NM_026087 Ceacam12 CEA-related cell adhesion molecule 12 2.53 NM_007543 Ceacam2 CEA-related cell adhesion molecule 2 2.61 NM_009884 Cebpg CCAAT/enhancer binding protein (C/EBP), gamma 5.01 NM_028131 Cenpn Centromere protein N 4.27 NM_021456 Ces1 Carboxylesterase 1 4.38 NM_011801 Cfdp1 Craniofacial development protein 1 3.18 NM_025351 Chchd6 Coiled-coil-helix-coiled-coil-helix domain containing 6 3.08 NM_009767 Chic1 Cysteine-rich hydrophobic domain 1 2.42

133 NM_024190 Chmp1b Chromatin modifying protein 1B 2.75 NM_029814 Chmp5 Chromatin modifying protein 5 6.52 NM_175752 Chn1 Chimerin (chimaerin) 1 2.84 NM_133709 Chrdl2 Chordin-like 2 3.02 NM_144803 Chrna2 Cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) 2.39 NM_021528 Chst12 Carbohydrate sulfotransferase 12 2.70 NM_153508 Clstn3 Calsyntenin 3 2.62 NM_025647 Cmpk Cytidylate kinase 7.44 NM_029746 Cog2 Component of oligomeric golgi complex 2 3.31 NM_015734 Col5a1 Procollagen, type V, alpha 1 2.51 NM_021538 Cope Coatomer protein complex, subunit epsilon 4.53 NM_019817 Copz1 Coatomer protein complex, subunit zeta 1 2.89 NM_009940 Coq7 Demethyl-Q 7 5.66 NM_009941 Cox4i1 Cytochrome c oxidase subunit IV isoform 1 3.85 NM_007752 Cp Ceruloplasmin 2.39 NM_021449 Crbn Cereblon 3.11 NM_019936 Cript Cysteine-rich PDZ-binding protein 4.84 NM_027945 Csl Citrate synthase like 3.47 NM_173185 Csnk1g1 Casein kinase 1, gamma 1 2.48 NM_009974 Csnk2a2 Casein kinase 2, alpha prime polypeptide 4.59 NM_145529 Cstf3 Cleavage stimulation factor, 3' pre-RNA, subunit 3 4.30 NM_025680 Ctnnbl1 Catenin, beta like 1 2.46 NM_023153 Cwc15 CWC15 homolog (S. cerevisiae) 2.78 NM_018866 Cxcl13 Chemokine (C-X-C motif) ligand 13 2.45 NM_028868 Cxxc1 CXXC finger 1 (PHD domain) 2.65 NM_001024926 Cyb5d2 Cytochrome b5 domain containing 2 4.20 NM_010007 Cyp2j5 Cytochrome P450, family 2, subfamily j, polypeptide 5 5.04 NM_021476 Cysltr1 Cysteinyl receptor 1 2.55 NM_001013379 D10627 CDNA sequence D10627 4.42 NM_028667 D3Ertd751e DNA segment, Chr 3, ERATO Doi 751, expressed 2.99 NM_198675 D630004A14Rik RIKEN cDNA D630004A14 gene 2.81 NM_033079 D6Mm5e DNA segment, Chr 6, Miriam Meisler 5, expressed 2.82 NM_026585 D6Wsu116e DNA segment, Chr 6, Wayne State University 116, expressed 4.07 NM_028523 Dcbld2 Discoidin, CUB and LCCL domain containing 2 4.42 NM_016890 Dctn3 Dynactin 3 2.49 NM_010026 Ddef1 Development and differentiation enhancing 2.48 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase NM_001003919 Ddx11 homolog, S. cerevisiae) 2.59 NM_172284 Ddx19b DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b 2.86 NM_028038 Ddx28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 2.54 NM_028074 Ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 7.84 NM_145975 Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 3.34 NM_026538 Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 2.91 NM_001039121 Defb43 Defensin beat 43 2.42 NM_153551 Dennd1c DENN/MADD domain containing 1C 2.58 NM_016811 Dgka Diacylglycerol kinase, alpha 3.19 NM_026144 Dhdds Dehydrodolichyl diphosphate synthase 3.08 NM_178367 Dhx33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 2.57 NM_177852 Dido1 Death inducer-obliterator 1 7.80 NM_015789 Dkkl1 Dickkopf-like 1 3.18 NM_010056 Dlx5 Distal-less homeobox 5 2.63 NM_133365 Dnahc5 Dynein, axonemal, heavy chain 5 3.13 NM_026400 Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 2.48 NM_133763 Dnttip1 Deoxynucleotidyltransferase, terminal, interacting protein 1 2.49 NM_172803 Dedicator of cytokinesis 4 3.45 NM_026082 Dock7 Dedicator of cytokinesis 7 3.17 NM_133803 Dpp3 Dipeptidylpeptidase 3 4.22 NM_010077 Drd2 Dopamine receptor 2 2.99 NM_007882 Dsc3 Desmocollin 3 2.46

134 NM_026981 Dtwd1 DTW domain containing 1 3.94 NM_026017 Dullard Dullard homolog (Xenopus laevis) 3.62 NM_028002 Dus4l Dihydrouridine synthase 4-like (S. cerevisiae) 3.74 NM_001013380 Dync1li2 Dynein, cytoplasmic 1 light intermediate chain 2 3.18 NM_001037957 Dyrk1b Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b 2.62 NM_033270 E2f6 E2F transcription factor 6 2.62 NM_177133 E330018D03Rik RIKEN cDNA E330018D03 gene 2.41 NM_007893 E4f1 E4F transcription factor 1 3.36 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 3.66 NM_053112 Ear10 Eosinophil-associated, ribonuclease A family, member 10 2.73 NM_007895 Ear2 Eosinophil-associated, ribonuclease A family, member 2 3.15 NM_177689 EG232599 Predicted gene, EG232599 2.49 NM_177764 EG269902 Predicted gene, EG269902 3.01 NM_183309 EG330305 Predicted gene, EG330305 2.73 NM_001033779 EG433632 Predicted gene, EG433632 2.55 NM_001008427 EG434179 Predicted gene, EG434179 2.69 NM_001034893 EG435970 Predicted gene, EG435970 3.07 NM_001024729 EG546150 Predicted gene, EG546150 2.80 NM_001034909 EG547347 Predicted gene, EG547347 2.87 NM_001039222 EG622139 Predicted gene, EG622139 3.47 NM_001037923 EG624866 Predicted gene, EG624866 3.61 NM_010124 Eif4ebp2 Eukaryotic translation initiation factor 4E binding protein 2 2.39 NM_053255 Elac1 ElaC homolog 1 (E. coli) 2.74 NM_007924 Ell Elongation factor RNA polymerase II 2.72 NM_026421 Enoph1 Enolase-phosphatase 1 5.47 NM_001026212 Ensa Endosulfine alpha 2.85 NM_177671 Epha10 Eph receptor A10 2.66 NM_010147 Epn1 Epsin 1 2.74 NM_007951 Erh Enhancer of rudimentary homolog (Drosophila) 2.74 NM_145502 Erlin1 ER lipid raft associated 1 2.89 NM_026983 Erp27 Endoplasmic reticulum protein 27 2.87 NM_007953 Esrra Estrogen related receptor, alpha 3.29 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide 2.61 NM_023794 Etv5 Ets variant gene 5 3.20 NM_177333 Exoc3 Exocyst complex component 3 3.00 NM_175353 Exoc6 Exocyst complex component 6 2.41 NM_010162 Ext1 Exostoses (multiple) 1 4.83 NM_028784 F13a1 Coagulation factor XIII, A1 subunit 2.68 NM_001033878 F830104D24Rik RIKEN cDNA F830104D24 gene 2.50 NM_010174 Fabp3 Fatty acid binding protein 3, muscle and heart 2.45 NM_026210 Fam18b Family with sequence similarity 18, member B 2.39 NM_175027 Fancb Fanconi anemia, complementation group B 3.25 NM_172422 Fastkd2 FAST kinase domains 2 2.79 NM_013910 Fbxl10 F-box and leucine-rich repeat protein 10 2.82 NM_175127 Fbxo28 F-box protein 28 4.03 NM_001033156 Fbxo33 F-box protein 33 2.91 NM_153195 Fbxo7 F-box protein 7 2.47 NM_015791 Fbxo8 F-box protein 8 2.97 NM_080428 Fbxw7 F-box and WD-40 domain protein 7, archipelago homolog (Drosophila) 3.20 NM_010186 Fcgr1 Fc receptor, IgG, high affinity I 2.44 NM_175684 Fchsd1 FCH and double SH3 domains 1 2.89 NM_139309 Fcmd Fukuyama type congenital muscular dystrophy homolog (human) 2.82 NM_010199 Fgf12 Fibroblast growth factor 12 2.75 NM_201230 Fgfr1op Fgfr1 oncogene partner 2.74 NM_010209 Fh1 Fumarate hydratase 1 4.64 NM_175276 Fhod3 Formin homology 2 domain containing 3 2.59 NM_016863 Fkbp1b FK506 binding protein 1b 2.82 NM_012056 Fkbp9 FK506 binding protein 9 2.63

135 NM_178382 Flrt3 Fibronectin leucine rich transmembrane protein 3 2.65 NM_016770 Folh1 Folate hydrolase 2.41 NM_183186 Foxn3 Forkhead box N3 2.69 NM_144939 Frs3 Fibroblast growth factor receptor substrate 3 2.88 NM_176966 Fsd1l Fibronectin type III and SPRY domain containing 1-like 7.16 NM_011936 Fto Fat mass and obesity associated 3.08 NM_025799 Fuca2 Fucosidase, alpha-L- 2, plasma 4.25 NM_010244 Fv1 Friend virus susceptibility 1 2.38 NM_020510 Fzd2 Frizzled homolog 2 (Drosophila) 5.00 NM_019749 Gabarap Gamma-aminobutyric acid receptor associated protein 2.81 NM_020590 Gabarapl1 Gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1 2.61 NM_172512 Gabpb2 GA repeat binding protein, beta 2 2.44 NM_008079 Galc Galactosylceramidase 3.46 NM_176963 Galm Galactose mutarotase 2.48 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_173030 Galnt13 acetylgalactosaminyltransferase 13 2.43 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N- NM_144731 Galnt7 acetylgalactosaminyltransferase 7 5.97 NM_008060 Ganab Alpha glucosidase 2 alpha neutral subunit 2.45 NM_025961 Gatm Glycine amidinotransferase (L-arginine:glycine amidinotransferase) 2.54 NM_019988 Gbl G protein beta subunit-like 3.08 NM_008100 Gcg Glucagon 2.53 NM_008105 Gcnt2 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme 2.53 NM_008109 Gdf5 Growth differentiation factor 5 2.44 NM_010273 Gdi1 Guanosine diphosphate (GDP) dissociation inhibitor 1 2.41 NM_023040 Gfer Growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) 2.43 NM_008114 Gfi1b Growth factor independent 1B 2.63 NM_008125 Gjb2 Gap junction membrane channel protein beta 2 3.76 NM_019832 Gkap1 G kinase anchoring protein 1 3.67 NM_025466 Gkn1 Gastrokine 1 5.04 NM_025374 Glo1 Glyoxalase 1 2.64 NM_010298 Glrb Glycine receptor, beta subunit 4.21 NM_008132 Glrp1 Glutamine repeat protein 1 3.26 NM_153601 Gluld1 Glutamate-ammonia ligase (glutamine synthetase) domain containing 1 3.26 NM_001033362 Gm614 Gene model 614, (NCBI) 3.48 NM_010312 Gnb2 Guanine nucleotide binding protein, beta 2 6.98 NM_138719 Gnb5 Guanine nucleotide binding protein, beta 5 2.67 Guanine nucleotide binding protein (G protein), gamma transducing activity NM_010314 Gngt1 polypeptide 1 3.25 NM_008145 Gnrh1 Gonadotropin releasing hormone 1 2.72 NM_008146 Golga3 Golgi autoantigen, golgin subfamily a, 3 3.14 NM_011821 Gpc6 Glypican 6 4.55 NM_030084 Gpr108 G protein-coupled receptor 108 2.82 NM_133776 Gpr110 G protein-coupled receptor 110 3.60 NM_153394 Gpr156 G protein-coupled receptor 156 5.89 NM_030733 Gpr63 G protein-coupled receptor 63 3.14 NM_030720 Gpr84 G protein-coupled receptor 84 2.41 NM_181444 Gprc5a G protein-coupled receptor, family C, group 5, member A 2.65 NM_178700 Grsf1 G-rich RNA sequence binding factor 1 2.98 NM_001031667 Gsk3a Glycogen synthase kinase 3 alpha 2.86 NM_008180 Gss 2.91 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 3.28 NM_181410 Gtf2h3 General transcription factor IIH, polypeptide 3 2.73 NM_032544 Gtpbp3 GTP binding protein 3 5.59 NM_008191 Guca2b Guanylate cyclase activator 2b (retina) 2.41 NM_001007576 Gucy2f Guanylate cyclase 2f 2.42 NM_010293 Gykl1 Glycerol kinase-like 1 2.90 NM_010369 Gypa 2.52 NM_010373 Gzme Granzyme E 3.87

136 NM_207105 H2-Ab1 Histocompatibility 2, class II antigen A, beta 1 3.86 NM_201608 H2-M10.3 Histocompatibility 2, M region locus 10.3 2.69 NM_008204 H2-M2 Histocompatibility 2, M region locus 2 7.15 NM_013819 H2-M3 Histocompatibility 2, M region locus 3 3.27 NM_010436 H2afx H2A histone family, member X 2.50 NM_177900 Hapln4 Hyaluronan and proteoglycan link protein 4 2.92 NM_153198 Hbp1 High mobility group box transcription factor 1 2.56 NM_008225 Hcls1 Hematopoietic cell specific Lyn substrate 1 3.19 NM_010408 Hcn1 Hyperpolarization-activated, cyclic nucleotide-gated K+ 1 2.49 NM_010412 Hdac5 2.76 NM_008233 Hdgfrp2 Hepatoma-derived growth factor, related protein 2 2.55 NM_010419 Hes5 Hairy and enhancer of split 5 (Drosophila) 2.42 NM_008244 Hgs HGF-regulated tyrosine kinase substrate 2.39 NM_172746 Hirip3 HIRA interacting protein 3 2.91 NM_178207 Hist1h3i Histone cluster 1, H3i 2.81 NM_178192 Hist1h4a Histone cluster 1, H4a 2.61 NM_178208 Hist1h4c Histone cluster 1, H4c 2.96 NM_001024720 Hmcn1 Hemicentin 1 3.56 NM_008255 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 3.56 NM_030014 Hook1 Hook homolog 1 (Drosophila) 4.16 NM_008270 Hoxb9 Homeo box B9 2.55 NM_025330 Hsd17b14 Hydroxysteroid (17-beta) dehydrogenase 14 2.63 NM_011939 Hsf4 Heat shock transcription factor 4 2.53 NM_013558 Hspa1l Heat shock protein 1-like 2.82 NM_008309 Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 2.97 NM_008310 Htr1f 5-hydroxytryptamine (serotonin) receptor 1F 2.74 NM_172812 Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 4.30 NM_008319 Icam5 Intercellular adhesion molecule 5, telencephalin 2.56 NM_031166 Id4 Inhibitor of DNA binding 4 2.61 NM_010498 Ids Iduronate 2-sulfatase 3.22 NM_008325 Idua Iduronidase, alpha-L- 2.64 NM_008332 Ifit2 Interferon-induced protein with tetratricopeptide repeats 2 3.45 NM_010508 Ifnar1 Interferon (alpha and beta) receptor 1 2.57 NM_008337 Ifng 4.75 NM_134126 Ift140 Intraflagellar transport 140 homolog (Chlamydomonas) 3.04 NM_026298 Ift172 Intraflagellar transport 172 homolog (Chlamydomonas) 3.36 NM_009879 Ift81 Intraflagellar transport 81 homolog (Chlamydomonas) 2.75 NM_009376 Ift88 Intraflagellar transport 88 homolog (Chlamydomonas) 2.66 NM_010512 Igf1 Insulin-like growth factor 1 2.53 NM_183335 Igsf1 Immunoglobulin superfamily, member 1 2.52 NM_011879 Ik IK cytokine 3.66 NM_008361 Il1b Interleukin 1 beta 2.43 NM_011829 Impdh1 Inosine 5'-phosphate dehydrogenase 1 5.27 NM_011830 Impdh2 Inosine 5'-phosphate dehydrogenase 2 2.97 NM_016692 Incenp Inner centromere protein 2.48 NM_133345 Ing4 Inhibitor of growth family, member 4 3.68 NM_010565 Inhbc Inhibin beta-C 3.23 NM_183144 Inpp5a Inositol polyphosphate-5-phosphatase A 2.50 NM_013754 Insl6 Insulin-like 6 2.63 NM_153414 Ints9 Integrator complex subunit 9 2.85 NM_008391 Irf2 Interferon regulatory factor 2 2.47 NM_153134 Irgq Immunity-related GTPase family, Q 3.72 NM_177663 Isg20l2 Interferon stimulated exonuclease gene 20-like 2 4.34 NM_133934 Isy1 ISY1 splicing factor homolog (S. cerevisiae) 4.11 NM_010577 Itga5 (fibronectin receptor alpha) 2.72 NM_026348 Itgb3bp binding protein (beta3-endonexin) 2.64 NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 2.49 NM_008410 Itm2b Integral membrane protein 2B 2.68

137 NM_026365 Jagn1 Jagunal homolog 1 (Drosophila) 2.73 NM_025368 Josd2 Josephin domain containing 2 2.92 NM_011835 Katna1 Katanin p60 (ATPase-containing) subunit A1 2.90 NM_021275 Kcna4 Potassium voltage-gated channel, shaker-related subfamily, member 4 2.89 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 3.74 NM_177791 Kctd19 Potassium channel tetramerisation domain containing 19 2.71 NM_172509 Kctd7 Potassium channel tetramerisation domain containing 7 3.13 NM_029550 Keg1 Kidney expressed gene 1 2.80 NM_032540 Kel Kell blood group 4.76 NM_010613 Khsrp KH-type splicing regulatory protein 2.57 NM_010616 Kif12 Kinesin family member 12 2.57 NM_010620 Kif15 Kinesin family member 15 3.42 NM_009004 Kif20a Kinesin family member 20A 4.49 NM_177784 Klhl23 Kelch-like 23 (Drosophila) 2.87 NM_175174 Klhl5 Kelch-like 5 (Drosophila) 2.88 NM_008459 Klra10 Killer cell lectin-like receptor subfamily A, member 10 3.48 NM_010651 Klra9 Killer cell lectin-like receptor subfamily A, member 9 2.74 NM_008465 Kpna1 Karyopherin (importin) alpha 1 2.60 NM_008379 Kpnb1 Karyopherin (importin) beta 1 2.60 NM_133727 Kptn Kaptin 4.19 NM_008485 Lamc2 Laminin, gamma 2 2.88 NM_010686 Laptm5 Lysosomal-associated protein transmembrane 5 2.82 NM_010688 Lasp1 LIM and SH3 protein 1 3.45 NM_015771 Lats2 Large tumor suppressor 2 2.45 NM_010704 Lepr Leptin receptor 3.16 NM_001039653 Lhx3 LIM homeobox protein 3 2.88 NM_024471 Lias Lipoic acid synthetase 2.96 NM_176953 Lig4 Ligase IV, DNA, ATP-dependent 2.90 NM_029377 Lin37 Lin-37 homolog (C. elegans) 3.51 NM_010723 Lmo4 LIM domain only 4 2.45 NM_172767 Loh11cr2a Loss of heterozygosity, 11, chromosomal region 2, gene A homolog (human) 8.65 NM_013586 Loxl3 Lysyl oxidase-like 3 2.88 NM_028973 Lrrc15 Leucine rich repeat containing 15 2.74 NM_153074 Lrrc25 Leucine rich repeat containing 25 3.15 NM_029044 Lrrc48 Leucine rich repeat containing 48 3.63 NM_198250 Lrrc4b Leucine rich repeat containing 4B 3.51 NM_001013382 Lrrc52 Leucine rich repeat containing 52 3.53 NM_008516 Lrrn1 Leucine rich repeat protein 1, neuronal 2.96 NM_015816 Lsm4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.73 NM_133792 Lypla3 Lysophospholipase 3 2.64 NM_027985 Mad2l2 MAD2 mitotic arrest deficient-like 2 (yeast) 2.79 NM_020015 Magea1 Melanoma antigen, family A, 1 2.61 NM_020018 Magea5 Melanoma antigen, family A, 5 3.99 NM_001004176 Maml3 Mastermind like 3 (Drosophila) 3.05 NM_001029983 Man1b1 Mannosidase, alpha, class 1B, member 1 2.42 NM_028636 Man2c1 Mannosidase, alpha, class 2C, member 1 3.04 NM_011840 Map2k5 Mitogen activated protein kinase kinase 5 3.11 NM_022012 Map3k11 Mitogen activated protein kinase kinase kinase 11 3.60 NM_021921 Mapk8ip2 Mitogen-activated protein kinase 8 interacting protein 2 2.82 NM_026037 Mboat2 Membrane bound O-acyltransferase domain containing 2 3.47 NM_023061 Mcam Melanoma cell adhesion molecule 2.51 NM_001030014 Mcat Malonyl CoA:ACP acyltransferase (mitochondrial) 2.71 NM_025297 Mecr Mitochondrial trans-2-enoyl-CoA reductase 3.21 NM_020048 Med20 Mediator complex subunit 20 4.05 NM_027485 Med26 Mediator complex subunit 26 2.43 NM_026896 Med27 Mediator complex subunit 27 2.83 NM_026068 Med31 Mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) 2.89 NM_133201 Mfn2 Mitofusin 2 2.41

138 NM_178620 Mfsd11 Major facilitator superfamily domain containing 11 4.16 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 3.95 NM_027696 Mier1 Mesoderm induction early response 1 homolog (Xenopus laevis 3.22 NM_001039081 Mier1 Mesoderm induction early response 1 homolog (Xenopus laevis 3.37 NM_018810 Mkrn1 Makorin, ring finger protein, 1 2.43 NM_008607 Mmp13 Matrix metallopeptidase 13 2.48 NM_152944 Mmp21 Matrix metallopeptidase 21 2.39 NM_019944 Mnx1 Motor neuron and pancreas homeobox 1 2.51 NM_001039364 Mobp Myelin-associated oligodendrocytic basic protein 7.21 NM_194269 Morn2 MORN repeat containing 2 5.47 NM_008622 Mpv17 Mpv17 transgene, kidney disease mutant 3.20 NM_008209 Mr1 Major histocompatibility complex, class I-related 2.72 NM_207538 Mrgprb5 MAS-related GPR, member B5 3.52 NM_025302 Mrpl2 Mitochondrial ribosomal protein L2 4.55 NM_026591 Mrpl24 Mitochondrial ribosomal protein L24 3.48 NM_053162 Mrpl34 Mitochondrial ribosomal protein L34 2.81 NM_023167 Mrpl4 Mitochondrial ribosomal protein L4 2.41 NM_025595 Mrpl51 Mitochondrial ribosomal protein L51 2.38 NM_025450 Mrps17 Mitochondrial ribosomal protein S17 2.51 NM_078479 Mrps21 Mitochondrial ribosomal protein S21 3.28 NM_026422 Mrrf Mitochondrial ribosome recycling factor 4.45 NM_025658 Ms4a4d Membrane-spanning 4-domains, subfamily A, member 4D 3.07 NM_031870 Msh4 MutS homolog 4 (E. coli) 3.11 NM_133767 Mtif2 Mitochondrial translational initiation factor 2 2.68 NM_028801 Muc5b Mucin 5, subtype B, tracheobronchial 3.79 NM_008650 Mut Methylmalonyl-Coenzyme A mutase 3.24 NM_133250 Mutyh MutY homolog (E. coli) 2.37 NM_010751 Mxd1 MAX dimerization protein 1 2.76 NM_016776 Mybbp1a MYB binding protein (P160) 1a 2.40 NM_008653 Mybpc3 Myosin binding protein C, cardiac 2.64 NM_001009546 Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.49 NM_010872 Naip2 NLR family, apoptosis inhibitory protein 2 3.18 NM_153126 Nat10 N-acetyltransferase 10 2.78 NM_026425 Nat5 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) 2.96 NM_134094 Ncald delta 2.68 NM_010811 Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.39 NM_024197 Ndufa10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 2.83 NM_025348 Ndufa3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 3.45 NM_019435 Ndufb11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 2.83 NM_025316 Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 2.70 NM_145518 Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 2.78 NM_010892 Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 2.74 NM_177898 Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5 2.62 NM_026890 Ngdn Neuroguidin, EIF4E binding protein 2.86 NM_021504 Ngly1 N-glycanase 1 4.37 NM_025937 Nkap RIKEN cDNA 2610020O08 gene 4.16 NM_029891 Nkrf NF-kappaB repressing factor 5.07 NM_175532 Nlrp10 NLR family, pyrin domain containing 10 3.26 NM_001004194 Nlrp4e NLR family, pyrin domain containing 4E 2.77 NM_001008421 Nol10 Nucleolar protein 10 2.93 NM_001039351 Nolc1 Nucleolar and coiled-body phosphoprotein 1 3.64 NM_181547 Nostrin trafficker 2.81 NM_175263 Notum Notum pectinacetylesterase homolog (Drosophila) 3.44 NM_008720 Npc1 Niemann Pick type C1 2.42 NM_010933 Nppc Natriuretic peptide precursor type C 2.74 NM_030676 Nr5a2 Nuclear receptor subfamily 5, group A, member 2 2.38 NM_146150 Nrd1 Nardilysin, N-arginine dibasic convertase, NRD convertase 1 3.05 NM_172544 Nrxn3 Neurexin III 4.23

139 NM_178925 Nsun3 NOL1/NOP2/Sun domain family 3 2.55 NM_008749 Nucb1 Nucleobindin 1 4.49 NM_153136 Nudt18 Nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.74 NM_001024205 Nufip2 Nuclear fragile X mental retardation protein interacting protein 2 2.63 NM_172410 Nup93 Nucleoporin 93 4.66 NM_022979 Nup98 Nucleoporin 98 2.68 NM_170591 Nupl1 Nucleoporin like 1 2.39 NM_008750 Nxn Nucleoredoxin 3.43 NM_010956 Ogdh Oxoglutarate dehydrogenase (lipoamide) 3.04 NM_146833 Olfr103 Olfactory receptor 103 2.46 NM_146582 Olfr1046 Olfactory receptor 1046 2.75 NM_147010 Olfr1052 Olfactory receptor 1052 3.04 NM_146843 Olfr1097 Olfactory receptor 1097 2.60 NM_146845 Olfr1098 Olfactory receptor 1098 2.85 NM_146844 Olfr1107 Olfactory receptor 1107 3.00 NM_001013575 Olfr112 Olfactory receptor 112 2.54 NM_146289 Olfr113 Olfactory receptor 113 2.72 NM_207566 Olfr1173 Olfactory receptor 1173 2.43 NM_146530 Olfr1186 Olfactory receptor 1186 2.81 NM_001011517 Olfr1193 Olfactory receptor 1193 2.65 NM_146454 Olfr1231 Olfactory receptor 1231 2.76 NM_147062 Olfr124 Olfactory receptor 124 2.40 NM_001011805 Olfr1385 Olfactory receptor 1385 2.91 NM_020515 Olfr140 Olfactory receptor 140 2.61 NM_146806 Olfr143 Olfactory receptor 143 2.41 NM_146303 Olfr1449 Olfactory receptor 1449 3.15 NM_020512 Olfr1507 Olfactory receptor 1507 3.24 NM_019473 Olfr155 Olfactory receptor 155 2.39 NM_146779 Olfr196 Olfactory receptor 196 2.50 NM_010970 Olfr23 Olfactory receptor 23 2.56 NM_146269 Olfr247 Olfactory receptor 247 2.72 NM_146415 Olfr291 Olfactory receptor 291 3.01 NM_146950 Olfr341 Olfactory receptor 341 3.41 NM_146938 Olfr346 Olfactory receptor 346 3.01 NM_146709 Olfr411 Olfactory receptor 411 3.51 NM_146718 Olfr430 Olfactory receptor 430 2.70 NM_146654 Olfr438 Olfactory receptor 438 2.96 NM_146413 Olfr463 Olfactory receptor 463 3.90 NM_146925 Olfr481 Olfactory receptor 481 3.25 NM_146956 Olfr525 Olfactory receptor 525 4.20 NM_147101 Olfr549 Olfactory receptor 549 4.89 NM_147041 Olfr57 Olfactory receptor 57 2.38 NM_013617 Olfr64 Olfactory receptor 64 3.52 NM_147048 Olfr652 Olfactory receptor 652 2.67 NM_146814 Olfr665 Olfactory receptor 665 2.43 NM_146355 Olfr692 Olfactory receptor 692 2.70 NM_146547 Olfr771 Olfactory receptor 771 3.76 NM_146670 Olfr815 Olfactory receptor 815 3.11 NM_146605 Olfr828 Olfactory receptor 828 2.48 NM_001011824 Olfr832 Olfactory receptor 832 2.73 NM_001011823 Olfr834 Olfactory receptor 834 2.73 NM_146482 Olfr889 Olfactory receptor 889 2.58 NM_146802 Olfr902 Olfactory receptor 902 2.68 NM_001011864 Olfr917 Olfactory receptor 917 2.52 NM_001011518 Olfr94 Olfactory receptor 94 3.79 NM_146330 Olfr958 Olfactory receptor 958 3.27 NM_146510 Olfr98 Olfactory receptor 98 2.57 NM_146286 Olfr981 Olfactory receptor 981 2.42

140 NM_146433 Olfr994 Olfactory receptor 994 3.25 NM_146434 Olfr995 Olfactory receptor 995 3.72 NM_207525 Opa3 Optic atrophy 3 (human) 2.75 NM_198424 Orai3 ORAI calcium release-activated calcium modulator 3 2.54 NM_011015 Orc1l Origin recognition complex, subunit 1-like (S.cereviaiae) 3.93 NM_026833 ORF19 Open reading frame 19 3.13 NM_025661 Ormdl3 ORM1-like 3 (S. cerevisiae) 2.74 NM_001034900 OTTMUSG00000015743 Predicted gene, OTTMUSG00000015743 4.10 NM_134150 Otub1 OTU domain, ubiquitin aldehyde binding 1 2.41 NM_172908 Ovch2 Ovochymase 2 2.71 NM_172555 Papolg Poly(A) polymerase gamma 3.15 NM_023115 Pcdh15 Protocadherin 15 2.46 NM_053139 Pcdhb14 Protocadherin beta 14 2.48 NM_053129 Pcdhb4 Protocadherin beta 4 2.53 NM_197992 Pcgf1 Polycomb group ring finger 1 4.44 NM_008797 Pcx Pyruvate carboxylase 2.52 NM_011053 Pdcd11 Programmed cell death protein 11 2.61 NM_001039376 Pde4dip Phosphodiesterase 4D interacting protein (myomegalin) 2.62 NM_172665 Pdk1 Pyruvate dehydrogenase kinase, isoenzyme 1 2.51 NM_133667 Pdk2 Pyruvate dehydrogenase kinase, isoenzyme 2 3.16 NM_026441 Pef1 Penta-EF hand domain containing 1 6.69 NM_029231 Pelp1 Proline, and leucine rich protein 1 2.66 NM_153796 Peo1 Progressive external ophthalmoplegia 1 (human) 3.16 NM_011070 Pfdn2 Prefoldin 2 2.86 NM_025700 Pgm1 Phosphoglucomutase 1 2.61 NM_008887 Phox2a Paired-like homeobox 2a 2.43 NM_029293 Phpt1 Phosphohistidine phosphatase 1 2.44 NM_018889 Pigb Phosphatidylinositol glycan anchor biosynthesis, class B 2.38 NM_031376 Pik3ap1 Phosphoinositide-3-kinase adaptor protein 1 2.68 NM_181414 Pik3c3 Phosphoinositide-3-kinase, class 3 3.33 NM_011098 Pitx2 Paired-like homeodomain transcription factor 2 2.90 NM_008861 Pkd2 Polycystic kidney disease 2 3.25 NM_011109 Pla2g2d Phospholipase A2, group IID 2.58 NM_172695 Plaa Phospholipase A2, activating protein 3.15 NM_207229 Plac9 Placenta specific 9 2.96 NM_019549 Plek Pleckstrin 2.66 NM_008885 Pmp22 Peripheral myelin protein 3.97 NM_027438 Pnma1 Paraneoplastic antigen MA1 2.68 NM_001033225 Pnrc1 Proline-rich nuclear receptor coactivator 1 2.94 NM_026383 Pnrc2 Proline-rich nuclear receptor coactivator 2 2.95 NM_008892 Pola1 Polymerase (DNA directed), alpha 1 3.19 NM_011130 Polb Polymerase (DNA directed), beta 2.67 NM_011132 Pole Polymerase (DNA directed), epsilon 3.08 NM_026329 Polr2g Polymerase (RNA) II (DNA directed) polypeptide G 2.74 NM_172551 Polrmt Polymerase (RNA) mitochondrial (DNA directed) 2.53 NM_025390 Pop4 Processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae) 4.55 NM_015784 Postn Periostin, osteoblast specific factor 2.61 NM_198933 Pou2f1 POU domain, class 2, transcription factor 1 2.47 NM_008902 Pp11r Placental protein 11 related 4.06 NM_144954 Ppil2 Peptidylprolyl isomerase (cyclophilin)-like 2 2.67 NM_008014 Ppm1g Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 3.17 NM_175934 Ppp1r10 Protein phosphatase 1, regulatory subunit 10 3.20 NM_021529 Ppp2r3c Protein phosphatase 2, regulatory subunit B'', gamma 3.17 NM_144880 Ppp2r5a Protein phosphatase 2, regulatory subunit B (B56), alpha isoform 3.34 NM_177242 Pptc7 PTC7 protein phosphatase homolog (S. cerevisiae) 2.84 NM_172574 Pqlc3 PQ loop repeat containing 2.76 NM_178249 Pramel6 Preferentially expressed antigen in melanoma like 6 2.50 NM_028243 Prcp Prolylcarboxypeptidase (angiotensinase C) 5.41

141 NM_008925 Prkcsh Protein kinase C substrate 80K-H 3.41 NM_011164 Prl Prolactin 3.61 NM_025834 Proz , vitamin K-dependent plasma glycoprotein 2.74 NM_013830 Prpf4b PRP4 pre-mRNA processing factor 4 homolog B (yeast) 2.41 NM_011181 Pscd2 Pleckstrin homology, Sec7 and coiled-coil domains 2 2.45 NM_139200 Pscdbp Pleckstrin homology, Sec7 and coiled-coil domains, binding protein 2.56 NM_011185 Psmb1 Proteasome (prosome, macropain) subunit, beta type 1 2.65 NM_011970 Psmb2 Proteasome (prosome, macropain) subunit, beta type 2 9.58 NM_011188 Psmc2 Proteasome (prosome, macropain) 26S subunit, ATPase 2 2.50 NM_008950 Psmc5 Protease (prosome, macropain) 26S subunit, ATPase 5 2.41 NM_178616 Psmd11 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 3.04 NM_008953 Psp Parotid secretory protein 3.16 NM_025682 Pspc1 Paraspeckle protein 1 2.43 NM_011197 Ptgfrn Prostaglandin F2 receptor negative regulator 2.39 NM_007982 Ptk2 PTK2 protein 2.47 NM_008986 Ptrf Polymerase I and transcript release factor 3.09 NM_175004 Ptrh2 Peptidyl-tRNA hydrolase 2 3.24 NM_008989 Pura Purine rich element binding protein A 2.81 NM_145458 Pxk PX domain containing serine/threonine kinase 4.87 NM_153781 Pygb Brain 2.92 NM_175543 Rab11fip4 RAB11 family interacting protein 4 (class II) 2.38 NM_028238 Rab38 Rab38, member of RAS oncogene family 3.12 NM_175562 Rab39 RAB39, member RAS oncogene family 3.99 NM_010261 Rabac1 Rab acceptor 1 (prenylated) 4.05 NM_146121 Rabgap1 RAB GTPase activating protein 1 3.79 NM_145510 Rabif RAB interacting factor 3.17 NM_011234 Rad51 RAD51 homolog (S. cerevisiae) 3.61 NM_011237 Rad9 RAD9 homolog (S. pombe) 3.00 NM_009067 Ralbp1 RalA binding protein 1 2.43 NM_023130 Raly HnRNP-associated with lethal yellow 3.02 NM_011240 Ranbp2 RAN binding protein 2 3.04 NM_177721 Ranbp6 RAN binding protein 6 2.61 NM_019930 Ranbp9 RAN binding protein 9 3.47 NM_029519 Rap2a RAS related protein 2a 3.41 NM_175930 Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 3.32 NM_011246 Rasgrp1 RAS guanyl releasing protein 1 3.22 NM_009826 Rb1cc1 RB1-inducible coiled-coil 1 5.04 NM_172517 Rbbp5 Retinoblastoma binding protein 5 2.45 NM_028226 Rbm12b RNA binding motif protein 12B 2.62 NM_009032 Rbm4 RNA binding motif protein 4 2.68 NM_025875 Rbm8a RNA binding motif protein 8a 2.48 NM_030598 Rcan2 Regulator of calcineurin 2 2.38 NM_173445 Rccd1 RCC1 domain containing 1 2.48 NM_007874 Reep5 Receptor accessory protein 5 2.41 NM_009044 Rel Reticuloendotheliosis oncogene 2.71 NM_181988 Rerg RAS-like, estrogen-regulated, growth-inhibitor 2.56 NM_175389 Rg9mtd2 RNA (guanine-9-) methyltransferase domain containing 2 3.35 NM_011267 Rgs16 Regulator of G-protein signaling 16 10.45 NM_001039688 Rhox4a Reproductive homeobox 4A 2.44 NM_001039695 Rhox4d Reproductive homeobox 4D 2.38 NM_201236 Rhox4e Reproductive homeobox 4E 2.40 NM_001039698 Rhox4h Reproductive homeobox 4H 2.40 NM_008955 Rhox6 Reproductive homeobox 6 3.32 NM_023894 Rhox9 Reproductive homeobox 9 2.65 NM_177620 Rin3 Ras and Rab interactor 3 2.47 NM_025346 Rmnd5b Required for meiotic nuclear division 5 homolog B (S. cerevisiae) 3.32 NM_027187 Rnaseh2a Ribonuclease H2, large subunit 2.76 NM_182999 Rnf20 Ring finger protein 20 2.63

142 NM_019403 Rnf5 Ring finger protein 5 2.69 NM_026440 Rnmt RNA (guanine-7-) methyltransferase 2.48 NM_009072 Rock2 Rho-associated coiled-coil containing protein kinase 2 2.72 NM_024218 Rpl24 Ribosomal protein L24 3.25 NM_021338 Rpl35a Ribosomal protein L35a 3.45 NM_026055 Rpl39 Ribosomal protein L39 2.54 NM_024212 Rpl4 Ribosomal protein L4 3.25 NM_013725 Rps11 Ribosomal protein S11 2.41 NM_011295 Rps12 Ribosomal protein S12 4.69 NM_023133 Rps19 Ribosomal protein S19 2.84 NM_009093 Rps29 Ribosomal protein S29 2.77 NM_009096 Rps6 Ribosomal protein S6 3.20 NM_173450 Rpusd2 RNA pseudouridylate synthase domain containing 2 2.40 NM_009103 Rrm1 M1 2.72 NM_199476 Rrm2b Ribonucleotide reductase M2 B (TP53 inducible) 4.13 NM_021511 Rrs1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.81 NM_194052 Rtn4 Reticulon 4 2.66 NM_175542 Rttn Rotatin 3.41 NM_027530 Rufy3 RUN and FYVE domain containing 3 2.61 NM_001034060 Rufy4 RUN and FYVE domain containing 4 2.46 NM_009820 Runx2 Runt related transcription factor 2 2.53 NM_011315 Saa3 Serum amyloid A 3 2.45 NM_019748 Sae1 SUMO1 activating enzyme subunit 1 2.41 NM_016882 Sart1 Squamous cell carcinoma antigen recognized by T-cells 1 4.36 NM_022028 Sav1 Salvador homolog 1 (Drosophila) 2.63 NM_001008422 Scaf1 SR-related CTD-associated factor 1 3.59 NM_007644 Scarb2 Scavenger receptor class B, member 2 2.49 NM_029825 Scfd1 Sec1 family domain containing 1 2.59 NM_178672 Scfd2 Sec1 family domain containing 2 3.98 NM_009130 Scg3 Secretogranin III 8.13 NM_023374 Sdhb complex, subunit B, iron sulfur (Ip) 2.50 NM_153125 Sec16a SEC16 homolog A (S. cerevisiae) 2.83 NM_019787 Sec23b SEC23B (S. cerevisiae) 3.31 NM_001039089 Sel1l Sel-1 suppressor of lin-12-like (C. elegans) 2.80 Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, NM_013657 Sema3c (semaphorin) 3C 2.42 Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and NM_011976 Sema4g short cytoplasmic domain, (semaphorin) 4G 2.83 NM_025814 Serbp1 Serpine1 mRNA binding protein 1 2.43 NM_011111 Serpinb2 Serine (or cysteine) peptidase inhibitor, clade B, member 2 2.47 NM_009250 Serpini1 Serine (or cysteine) peptidase inhibitor, clade I, member 1 2.80 NM_145482 Setd4 SET domain containing 4 3.36 NM_175102 Sf3b5 Splicing factor 3b, subunit 5 3.25 NM_146083 Sfrs7 Splicing factor, arginine/serine-rich 7 2.43 NM_147779 Sftpb Surfactant associated protein B 2.71 NM_053198 Sfxn4 Sideroflexin 4 3.56 NM_199007 Sgol2 Shugoshin-like 2 (S. pombe) 2.59 NM_144838 Sgtb Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 3.14 NM_009167 Shc3 Src homology 2 domain-containing transforming protein C3 2.58 NM_009169 Shfm1 Split hand/foot malformation (ectrodactyly) type 1 5.10 NM_138676 Shkbp1 Sh3kbp1 binding protein 1 2.46 NM_011734 Siae Sialic acid acetylesterase 3.21 NM_011376 Sim1 Single-minded homolog 1 (Drosophila) 2.68 NM_145406 Slc10a3 Solute carrier family 10 (sodium/bile acid cotransporter family), member 3 3.16 NM_008766 Slc22a6 Solute carrier family 22 (organic anion transporter), member 6 2.38 Solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), NM_013770 Slc25a10 member 10 2.66 NM_011017 Slc25a15 Solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 6.60 Solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member NM_026071 Slc25a19 19 2.47

143 NM_007885 Slc26a2 Solute carrier family 26 (sulfate transporter), member 2 2.44 NM_022317 Slc28a3 Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 2.78 NM_009579 Slc30a1 Solute carrier family 30 (zinc transporter), member 1 3.13 NM_173865 Slc41a1 Solute carrier family 41, member 1 3.25 NM_145394 Slc44a3 Solute carrier family 44, member 3 2.61 NM_001038660 Slc7a15 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 2.55 NM_008540 Smad4 MAD homolog 4 (Drosophila) 2.98 NM_008574 Smcp Sperm mitochondria-associated cysteine-rich protein 2.39 NM_175491 Smcr8 Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) 2.41 NM_134034 Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 2.51 NM_029945 Smpd4 Sphingomyelin phosphodiesterase 4 2.88 NM_021535 Smu1 Smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.56 NM_025481 Smurf2 SMAD specific E3 ubiquitin protein ligase 2 3.55 NM_144918 Smyd5 SET and MYND domain containing 5 3.21 NM_013669 Snap91 Synaptosomal-associated protein 91 2.72 NM_133741 Snrk SNF related kinase 2.71 NM_019727 Snx1 Sorting nexin 1 4.88 NM_029068 Snx16 Sorting nexin 16 2.46 NM_080843 Socs4 Suppressor of cytokine signaling 4 2.46 NM_138657 Socs7 Suppressor of cytokine signaling 7 3.35 NM_019973 Son Son cell proliferation protein 2.38 NM_011438 Sox12 SRY-box containing gene 12 5.28 NM_011441 Sox17 SRY-box containing gene 17 4.94 NM_009238 Sox4 SRY-box containing gene 4 6.86 NM_013672 Sp1 Trans-acting transcription factor 1 3.02 NM_030220 Sp2 3.03 NM_017407 Spag5 Sperm associated antigen 5 2.82 NM_172561 Spag7 Sperm associated antigen 7 2.44 NM_029299 Spata19 Spermatogenesis associated 19 2.85 NM_020011 Sphk2 Sphingosine kinase 2 2.55 NM_177829 Spink10 Serine peptidase inhibitor, Kazal type 10 2.88 NM_173070 Sprr4 Small proline-rich protein 4 2.41 NM_009269 Sptlc1 Serine palmitoyltransferase, long chain base subunit 1 2.39 NM_175318 Spty2d1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 2.62 NM_009272 Srm Spermidine synthase 2.68 NM_011899 Srp54a Signal recognition particle 54a 3.09 NM_026130 Srpr Signal recognition particle receptor ('docking protein') 4.63 NM_173868 St18 Suppression of tumorigenicity 18 2.57 NM_016866 Stk39 Serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 2.74 NM_011499 Strap Serine/threonine kinase receptor associated protein 5.58 STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. NM_008408 Stt3a cerevisiae) 6.60 NM_011294 Sub1 SUB1 homolog (S. cerevisiae) 2.49 NM_009460 Sumo1 SMT3 suppressor of mif two 3 homolog 1 (yeast) 2.38 NM_181423 Supv3l1 Suppressor of var1, 3-like 1 (S. cerevisiae) 3.02 NM_172888 Svs1 Seminal vesicle secretory protein 1 2.49 NM_009303 Syngr1 Synaptogyrin 1 3.79 NM_053205 Taar1 Trace amine-associated receptor 1 2.59 NM_001010830 Taar8a Trace amine-associated receptor 8A 2.99 NM_001010840 Taar8c Trace amine-associated receptor 8C 2.64 NM_020047 Tacstd2 Tumor-associated calcium signal transducer 2 3.08 NM_026836 Taf11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor 2.78 NM_147155 Tagap1 T-cell activation GTPase activating protein 1 2.43 NM_019754 Tagln3 Transgelin 3 2.53 NM_207011 Tas2r104 Taste receptor, type 2, member 104 3.31 NM_199154 Tas2r107 Taste receptor, type 2, member 107 6.06 NM_198960 Tcfap2e Transcription factor AP-2, epsilon 2.39 NM_011548 Tcfe2a Transcription factor E2a 2.47 NM_027762 Tchhl1 Trichohyalin-like 1 4.57

144 NM_029992 Tchp Trichoplein, keratin filament binding 2.55 NM_011552 Tcof1 Treacher Collins Franceschetti syndrome 1, homolog 3.07 NM_009359 Tex9 Testis expressed gene 9 3.44 NM_146074 Tfb1m Transcription factor B1, mitochondrial 3.71 NM_031199 Tgfa Transforming growth factor alpha 2.55 NM_009373 Tgm2 Transglutaminase 2, C polypeptide 3.05 NM_177726 Tgm6 Transglutaminase 6 3.84 NM_009444 Tgoln1 Trans-golgi network protein 2.54 NM_199042 Thap1 THAP domain containing, apoptosis associated protein 1 2.71 NM_001001297 Thnsl1 Threonine synthase-like 1 (bacterial) 4.72 NM_153552 Thoc1 THO complex 1 3.15 NM_145585 Thumpd1 THUMP domain containing 1 2.45 NM_053256 Tifp39 Tuberoinfundibular peptide of 39 residues (TIP39) preprohormone 3.07 NM_011599 Tle1 Transducin-like enhancer of split 1, homolog of Drosophila E(spl) 2.48 NM_172051 Tmcc3 Transmembrane and coiled coil domains 3 2.45 NM_001033475 Tmed8 Transmembrane emp24 domain containing 8 4.13 NM_019790 Tmeff2 Transmembrane protein with EGF-like and two follistatin-like domains 2 2.67 NM_026734 Tmem126b Transmembrane protein 126B 2.50 NM_025480 Tmem128 Transmembrane protein 128 6.33 NM_025335 Tmem167 Transmembrane protein 167 2.83 NM_177694 Tmem16e Transmembrane protein 16E 3.34 NM_146234 Tmem32 Transmembrane protein 32 2.65 NM_025339 Tmem42 Transmembrane protein 42 2.48 NM_177601 Tmem60 Transmembrane protein 60 2.55 NM_144794 Tmem63a Transmembrane protein 63a 5.68 NM_027797 Tmem80 Transmembrane protein 80 2.37 NM_026519 Tmem85 Transmembrane protein 85 3.04 NM_198967 Tmtc1 Transmembrane and tetratricopeptide repeat containing 1 2.47 NM_009401 Tnfrsf8 Tumor necrosis factor receptor superfamily, member 8 2.49 NM_031880 Tnk1 Tyrosine kinase, non-receptor, 1 2.73 NM_144812 Tnrc6b Trinucleotide repeat containing 6b 2.37 NM_011622 Tom1 Target of myb1 homolog (chicken) 3.31 NM_173391 Tph2 2 3.44 NM_009906 Tpp1 3.04 NM_009418 Tpp2 Tripeptidyl peptidase II 2.40 NM_009422 Traf2 Tnf receptor-associated factor 2 3.86 NM_133252 Tram2 Translocating chain-associating membrane protein 2 2.71 NM_001024206 Trappc1 Trafficking protein particle complex 1 2.94 NM_146241 Trhde TRH-degrading enzyme 2.69 NM_026933 Triap1 TP53 regulated inhibitor of apoptosis 1 2.43 NM_145076 Trim24 Tripartite motif protein 24 3.28 NM_053170 Trim33 Tripartite motif protein 33 7.33 NM_194343 Trim45 Tripartite motif-containing 45 2.79 NM_001013616 Trim6 Tripartite motif protein 6 3.00 NM_013735 Trp53bp1 Transformation related protein 53 binding protein 1 4.18 NM_177781 Trpa1 Transient receptor potential cation channel, subfamily A, member 1 7.89 NM_138301 Trpm2 Transient receptor potential cation channel, subfamily M, member 2 2.40 NM_024168 Tsen34 TRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae) 2.90 NM_207228 Tsga10 Testis specific 10 2.46 NM_054073 Tsga13 Testis specific gene A13 3.85 NM_183099 Tssk5 Testis-specific serine kinase 5 3.26 NM_028735 Ttc21a Tetratricopeptide repeat domain 21A 2.52 NM_009441 Ttc3 Tetratricopeptide repeat domain 3 2.39 NM_175274 Ttyh3 Tweety homolog 3 (Drosophila) 3.29 NM_026473 Tubb6 Tubulin, beta 6 2.44 NM_172253 Twistnb TWIST neighbor 3.07 NM_013698 Txk TXK tyrosine kinase 2.55 NM_026132 Txndc8 Thioredoxin domain containing 8 2.46

145 NM_015762 Txnrd1 Thioredoxin reductase 1 3.31 NM_028283 Uaca Uveal autoantigen with coiled-coil domains and ankyrin repeats 2.46 NM_026872 Ubap2 Ubiquitin-associated protein 2 2.78 NM_011664 Ubb Ubiquitin B 2.73 NM_009457 Ube1x Ubiquitin-activating enzyme E1, Chr X 3.10 NM_145420 Ube2d1 Ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast) 2.55 NM_009455 Ube2e1 Ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast) 2.92 NM_133777 Ube2s Ubiquitin-conjugating enzyme E2S 2.52 NM_023585 Ube2v2 Ubiquitin-conjugating enzyme E2 variant 2 2.43 NM_172300 Ube2z Ubiquitin-conjugating enzyme E2Z (putative) 2.82 NM_145400 Ube4a Ubiquitination factor E4A, UFD2 homolog (S. cerevisiae) 6.80 NM_152234 Ubqln1 Ubiquilin 1 2.53 NM_026123 Unc50 Unc-50 homolog (C. elegans) 2.64 NM_138592 Usp39 Ubiquitin specific peptidase 39 2.85 NM_133992 Usp52 Ubiquitin specific peptidase 52 5.70 NM_019729 Usp8 Ubiquitin specific peptidase 8 2.85 NM_053226 V1rb3 Vomeronasal 1 receptor, B3 2.38 NM_053229 V1rb8 Vomeronasal 1 receptor, B8 2.42 NM_145843 V1rg1 Vomeronasal 1 receptor, G1 2.54 NM_134238 V1rh13 Vomeronasal 1 receptor, H13 3.06 NM_134216 V1rh7 Vomeronasal 1 receptor, H7 3.15 NM_009502 Vcl Vinculin 3.41 NM_001025250 Vegfa Vascular endothelial growth factor A 2.43 NM_028813 Vit Vitrin 2.56 NM_026664 Vps53 Vacuolar protein sorting 53 (yeast) 3.24 NM_145967 Vstm2a V-set and transmembrane domain containing 2A 2.58 NM_011710 Wars Tryptophanyl-tRNA synthetase 2.86 NM_016757 Wbp1 WW domain binding protein 1 2.67 NM_025362 Wbscr18 Williams-Beuren syndrome chromosome region 18 homolog (human) 3.53 NM_172882 Wdfy3 WD repeat and FYVE domain containing 3 3.01 NM_153391 Wdr19 WD repeat domain 19 2.45 NM_133734 Wdr23 WD repeat domain 23 2.55 NM_172470 Wdr35 WD repeat domain 35 4.63 NM_178739 Wdr40b WD repeat domain 40B 2.61 NM_172372 Wdr45 WD repeat domain 45 3.55 NM_025793 Wdr45l Wdr45 like 2.53 NM_026236 Wdr48 WD repeat domain 48 3.36 NM_080848 Wdr5 WD repeat domain 5 3.32 NM_026898 Wdr53 WD repeat domain 53 5.96 NM_026464 Wdr55 WD repeat domain 55 2.76 NM_176923 Wdr59 WD repeat domain 59 2.68 NM_001025375 Wdr61 WD repeat domain 61 2.85 NM_027946 Wdr68 WD repeat domain 68 2.42 NM_198606 Wdsof1 WD repeats and SOF domain containing 1 2.42 NM_001039501 Wfdc10 WAP four-disulfide core domain 10 3.21 NM_011914 Whsc2 Wolf-Hirschhorn syndrome candidate 2 (human) 2.53 NM_023653 Wnt2 Wingless-related MMTV integration site 2 2.40 NM_021539 Wsb2 WD repeat and SOCS box-containing 2 3.04 NM_177310 Xpnpep3 X-prolyl aminopeptidase (aminopeptidase P) 3, putative 3.06 NM_207633 Yipf6 Yip1 domain family, member 6 2.53 NM_013771 Yme1l1 YME1-like 1 (S. cerevisiae) 2.62 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, NM_018753 Ywhab beta polypeptide 2.72 NM_021397 Zbtb32 Zinc finger and BTB domain containing 32 2.47 NM_134003 Zc3h10 Zinc finger CCCH type containing 10 2.92 NM_146073 Zdhhc14 Zinc finger, DHHC domain containing 14 3.88 NM_172554 Zdhhc17 Zinc finger, DHHC domain containing 17 2.97 NM_028379 Zdhhc4 Zinc finger, DHHC domain containing 4 3.56 NM_178694 Zer1 Zer-1 homolog (C. elegans) 2.39

146 NM_009540 Zfa Zinc finger protein, autosomal 2.38 NM_133349 Zfand2a Zinc finger, AN1-type domain 2A 5.02 NM_011749 Zfp148 Zinc finger protein 148 3.55 NM_001013786 Zfp187 Zinc finger protein 187 2.49 NM_145547 Zfp189 Zinc finger protein 189 2.75 NM_020497 Zfp276 Zinc finger protein (C2H2 type) 276 2.73 NM_175428 Zfp295 Zinc finger protein 295 2.43 NM_030743 Zfp313 Zinc finger protein 313 2.56 NM_001001186 Zfp456 Zinc finger protein 456 2.52 NM_001003666 Zfp457 Zinc finger protein 457 3.88 NM_144515 Zfp52 Zinc finger protein 52 4.52 NM_172617 Zfp523 Zinc finger protein 523 2.58 NM_001033159 Zfp597 Zinc finger protein 597 2.68 NM_144523 Zfp622 Zinc finger protein 622 3.14 NM_175163 Zfp689 Zinc finger protein 689 3.56 NM_172918 Zfp75 Zinc finger protein 75 2.58 NM_146203 Zfp764 Zinc finger protein 764 2.57 NM_001025163 Zfp78 Zinc finger protein 78 2.51 NM_146185 Zfp790 Zinc finger protein 790 3.42 NM_009569 Zfpm1 Zinc finger protein, multitype 1 2.47 NM_177086 Zmat4 Zinc finger, matrin type 4 3.19 NM_172700 Zmpste24 Zinc metallopeptidase, STE24 homolog (S. cerevisiae) 3.19 NM_019831 Zmym3 Zinc finger, MYM-type 3 2.85 NM_001014900 Zmynd12 Zinc finger, MYND domain containing 12 2.83 NM_001033634 Zyg11b Zyg-ll homolog B (C. elegans) 3.32 NM_026204 3.74 NM_010678 3.08 NM_177722 2.60 NM_001033821 2.79 NM_027820 3.97 NM_001033787 2.67 NM_177100 2.99 NM_027923 2.42 NM_177121 2.71 NM_010015 3.94 NM_176991 3.11 NM_207269 2.84 NM_026297 3.80 NM_183107 2.47 NM_198646 2.81 NM_001033341 3.23 NM_053007 2.53 NM_175354 3.98 NM_174994 2.70 NM_001024849 2.56 NM_001034901 2.62 NM_011473 2.50 NM_019427 3.91 NM_175405 2.95 NM_027681 2.69 NM_181320 2.56 NM_172483 3.78 NM_008835 2.62 NM_001002772 2.69 NM_133217 3.11

SUPPLEMENTAL TABLE S11: Genes Demonstrating Decreased Phospho-CREB Binding in the Social Isolation Model (p<0.001)

147 Accession Number Symbol Name Fold Change NM_177115 3-Mar Membrane-associated ring finger (C3HC4) 3 0.38 NM_027920 8-Mar Membrane-associated ring finger (C3HC4) 8 0.31 NM_177597 11-Mar Membrane-associated ring finger (C3HC4) 11 0.36 NM_017461 1-Sep Septin 1 0.21 NM_001024911 10-Sep Septin 10 0.19 NM_212470 0610007C21Rik RIKEN cDNA 0610007C21 gene 0.35 NM_026661 0610011L14Rik RIKEN cDNA 0610011L14 gene 0.36 NM_026787 1110012L19Rik RIKEN cDNA 1110012L19 gene 0.37 NM_025370 1110018J18Rik RIKEN cDNA 1110018J18 gene 0.32 NM_026271 1110018M03Rik RIKEN cDNA 1110018M03 gene 0.28 NM_199197 1110032A13Rik RIKEN cDNA 1110032A13 gene 0.38 NM_026807 1110033F04Rik RIKEN cDNA 1110033F04 gene 0.32 NM_027269 1110034A24Rik RIKEN cDNA 1110034A24 gene 0.39 NM_026876 1190005F20Rik RIKEN cDNA 1190005F20 gene 0.20 NM_028055 1500005I02Rik RIKEN cDNA 1500005I02 gene 0.36 NM_027041 1700003M02Rik RIKEN cDNA 1700003M02 gene 0.40 NM_026317 1700016G05Rik RIKEN cDNA 1700016G05 gene 0.17 NM_001017419 1700021K02Rik RIKEN cDNA 1700021K02 gene 0.19 NM_027285 1700029I01Rik RIKEN cDNA 1700029I01 gene 0.30 NM_025969 1700034H14Rik RIKEN cDNA 1700034H14 gene 0.37 NM_026091 1700037H04Rik RIKEN cDNA 1700037H04 gene 0.30 NM_026625 1700067P10Rik RIKEN cDNA 1700067P10 gene 0.23 NM_197989 1810009O10Rik RIKEN cDNA 1810009O10 gene 0.37 NM_025473 1810037C20Rik RIKEN cDNA 1810037C20 gene 0.37 NM_174987 1810063B05Rik RIKEN cDNA 1810063B05 gene 0.36 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 0.32 NM_026194 1810074P20Rik RIKEN cDNA 1810074P20 gene 0.22 NM_025563 2010012O05Rik RIKEN cDNA 2010012O05 gene 0.16 NM_175153 2010321M09Rik RIKEN cDNA 2010321M09 gene 0.36 NM_027087 2300006N05Rik RIKEN cDNA 2300006N05 gene 0.35 NM_027104 2310002L09Rik RIKEN cDNA 2310002L09 gene 0.27 NM_172398 2310005E10Rik RIKEN cDNA 2310005E10 gene 0.39 NM_183281 2310005G13Rik RIKEN cDNA 2310005G13 gene 0.21 NM_029609 2310007H09Rik RIKEN cDNA 2310007H09 gene 0.26 NM_175107 2310022A10Rik RIKEN cDNA 2310022A10 gene 0.32 NM_173735 2310044G17Rik RIKEN cDNA 2310044G17 gene 0.24 NM_024185 2310047O13Rik RIKEN cDNA 2310047O13 gene 0.12 NM_026336 2310057J18Rik RIKEN cDNA 2310057J18 gene 0.39 NM_030208 2310079F23Rik RIKEN cDNA 2310079F23 gene 0.32 NM_025555 2410004B18Rik RIKEN cDNA 2410004B18 gene 0.28 NM_153152 2410015M20Rik RIKEN cDNA 2410015M20 gene 0.37 NM_029354 2410018G20Rik RIKEN cDNA 2410018G20 gene 0.37 NM_183088 2410018M08Rik RIKEN cDNA 2410018M08 gene 0.34 NM_028611 2410091C18Rik RIKEN cDNA 2410091C18 gene 0.19 NM_029747 2410137M14Rik RIKEN cDNA 2410137M14 gene 0.35 NM_183119 2410141K09Rik RIKEN cDNA 2410141K09 gene 0.31 NM_001025576 2610301F02Rik RIKEN cDNA 2610301F02 gene 0.32 NM_025599 2610528E23Rik RIKEN cDNA 2610528E23 gene 0.36 NM_145995 2700050L05Rik RIKEN cDNA 2700050L05 gene 0.35 NM_001007589 2700059D21Rik RIKEN cDNA 2700059D21 gene 0.34 NM_027279 2810422O20Rik RIKEN cDNA 2810422O20 gene 0.35 NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene 0.36 NM_026054 2810474O19Rik RIKEN cDNA 2810474O19 gene 0.32 NM_178399 3110035E14Rik RIKEN cDNA 3110035E14 gene 0.22 NM_178141 3830406C13Rik RIKEN cDNA 3830406C13 gene 0.36 NM_027512 3830417A13Rik RIKEN cDNA 3830417A13 gene 0.26 NM_021414 4631427C17Rik RIKEN cDNA 4631427C17 gene 0.39

148 NM_172698 4732418C07Rik RIKEN cDNA 4732418C07 gene 0.33 NM_145437 4732429D16Rik RIKEN cDNA 4732429D16 gene 0.27 NM_176987 4732471D19Rik RIKEN cDNA 4732471D19 gene 0.22 NM_172500 4831426I19Rik RIKEN cDNA 4831426I19 gene 0.30 NM_001024606 4833426J09Rik RIKEN cDNA 4833426J09 gene 0.26 NM_133797 4833439L19Rik RIKEN cDNA 4833439L19 gene 0.35 NM_001009544 4921501E09Rik RIKEN cDNA 4921501E09 gene 0.24 NM_025724 4921510H08Rik RIKEN cDNA 4921510H08 gene 0.39 NM_029773 4921517N04Rik RIKEN cDNA 4921517N04 gene 0.18 NM_026604 4921533L14Rik RIKEN cDNA 4921533L14 gene 0.19 NM_026256 4921537P18Rik RIKEN cDNA 4921537P18 gene 0.39 NM_026251 4930424G05Rik RIKEN cDNA 4930424G05 gene 0.35 NM_026248 4930430A15Rik RIKEN cDNA 4930430A15 gene 0.30 NM_028934 4930452B06Rik RIKEN cDNA 4930452B06 gene 0.33 NM_029131 4930503E14Rik RIKEN cDNA 4930503E14 gene 0.40 NM_175172 4930506M07Rik RIKEN cDNA 4930506M07 gene 0.35 NM_183111 4930563M21Rik RIKEN cDNA 4930563M21 gene 0.22 NM_001033807 4930567H17Rik RIKEN cDNA 4930567H17 gene 0.37 NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene 0.32 NM_177599 4932415M13Rik RIKEN cDNA 4932415M13 gene 0.37 NM_172901 4933405O20Rik RIKEN cDNA 4933405O20 gene 0.21 NM_025747 4933411K20Rik RIKEN cDNA 4933411K20 gene 0.18 NM_175670 4933425M15Rik RIKEN cDNA 4933425M15 gene 0.39 NM_177607 4933430I17Rik RIKEN cDNA 4933430I17 gene 0.34 NM_026233 4933434I20Rik RIKEN cDNA 4933434I20 gene 0.29 NM_026362 5033414D02Rik RIKEN cDNA 5033414D02 gene 0.32 NM_001033304 5330417C22Rik RIKEN cDNA 5330417C22 gene 0.28 NM_172639 5330431N19Rik RIKEN cDNA 5330431N19 gene 0.40 NM_177314 5330439B14Rik RIKEN cDNA 5330439B14 gene 0.26 NM_027768 5430402E10Rik RIKEN cDNA 5430402E10 gene 0.35 NM_025666 5730410I19Rik RIKEN cDNA 5730410I19 gene 0.30 NM_027457 5730437N04Rik RIKEN cDNA 5730437N04 gene 0.30 NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene 0.39 NM_028137 5730528L13Rik RIKEN cDNA 5730528L13 gene 0.38 NM_146091 5730596K20Rik RIKEN cDNA 5730596K20 gene 0.33 NM_178243 5830403L16Rik RIKEN cDNA 5830403L16 gene 0.23 NM_026368 5830433M19Rik RIKEN cDNA 5830433M19 gene 0.21 NM_001033301 6330505N24Rik RIKEN cDNA 6330505N24 gene 0.31 NM_153563 6330569M22Rik RIKEN cDNA 6330569M22 gene 0.31 NM_172600 6720456H20Rik RIKEN cDNA 6720456H20 gene 0.22 NM_175265 6720463M24Rik RIKEN cDNA 6720463M24 gene 0.23 NM_026558 6720467C03Rik RIKEN cDNA 6720467C03 gene 0.39 NM_001039552 9030025P20Rik RIKEN cDNA 9030025P20 gene 0.32 NM_177793 9030224M15Rik RIKEN cDNA 9030224M15 gene 0.33 NM_027834 9130008F23Rik RIKEN cDNA 9130008F23 gene 0.35 NM_177254 9330155M09Rik RIKEN cDNA 9330155M09 gene 0.38 NM_153086 9430022F06Rik RIKEN cDNA 9430022F06 gene 0.21 NM_176924 9530053A07Rik RIKEN cDNA 9530053A07 gene 0.29 NM_176943 9630028B13Rik RIKEN cDNA 9630028B13 gene 0.16 NM_177668 A030001H23Rik RIKEN cDNA A030001H23 gene 0.38 NM_001033391 A130090K04Rik RIKEN cDNA A130090K04 gene 0.38 NM_029972 A330104H05Rik RIKEN cDNA A330104H05 gene 0.34 NM_176956 A730018C14Rik RIKEN cDNA A730018C14 gene 0.29 NM_010661 A830036E02Rik RIKEN cDNA A830036E02 gene 0.41 NM_001033472 A830080D01Rik RIKEN cDNA A830080D01 gene 0.37 NM_026634 A930018P22Rik RIKEN cDNA A930018P22 gene 0.25 NM_029984 A930021C24Rik RIKEN cDNA A930021C24 gene 0.31 NM_172399 A930038C07Rik RIKEN cDNA A930038C07 gene 0.33

149 NM_001033208 AA407270 Expressed sequence AA407270 0.37 NM_172379 AA536717 Expressed sequence AA536717 0.23 NM_198608 Aars2 Alanyl-tRNA synthetase 2, mitochondrial (putative) 0.36 NM_011511 Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.32 NM_013853 Abcf2 ATP-binding cassette, sub-family F (GCN20), member 2 0.25 NM_030239 Abcg3 ATP-binding cassette, sub-family G (WHITE), member 3 0.39 NM_018811 Abhd2 Abhydrolase domain containing 2 0.25 NM_134076 Abhd4 Abhydrolase domain containing 4 0.34 NM_001033163 Abhd9 Abhydrolase domain containing 9 0.27 NM_007380 Abi1 Abl-interactor 1 0.25 NM_001014399 Abi3bp ABI gene family, member 3 (NESH) binding protein 0.37 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, NM_030718 Abo transferase B, alpha 1-3-galactosyltransferase) 0.33 NM_001009952 Abpd Androgen binding protein delta 0.38 NM_207262 Abpe Androgen binding protein epsilon 0.31 NM_178890 Abtb2 Ankyrin repeat and BTB (POZ) domain containing 2 0.34 NM_133360 Acaca Acetyl-Coenzyme A carboxylase alpha 0.36 NM_007424 Acan Aggrecan 0.39 NM_021370 Accn5 Amiloride-sensitive cation channel 5, intestinal 0.28 NM_009598 Ace Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.21 NM_207668 Acpp Acid phosphatase, prostate 0.36 NM_053178 Acsbg1 Acyl-CoA synthetase bubblegum family member 1 0.37 NM_001001981 Acsl3 Acyl-CoA synthetase long-chain family member 3 0.29 NM_001033599 Acsl6 Acyl-CoA synthetase long-chain family member 6 0.35 NM_080575 Acss1 Acyl-CoA synthetase short-chain family member 1 0.36 NM_001004365 Actr3b ARP3 actin-related protein 3 homolog B (yeast) 0.25 NM_007395 Acvr1b Activin A receptor, type 1B 0.40 NM_001007220 Adam22 A disintegrin and metallopeptidase domain 22 0.39 NM_010086 Adam24 A disintegrin and metallopeptidase domain 24 (testase 1) 0.40 NM_001009547 Adam26b A disintegrin and metallopeptidase domain 26B 0.20 NM_027665 Adam30 A disintegrin and metallopeptidase domain 30 0.20 NM_145745 Adam34 A disintegrin and metallopeptidase domain 34 0.25 NM_028105 Adck1 AarF domain containing kinase 1 0.36 NM_134052 Adi1 Acireductone dioxygenase 1 0.36 NM_028121 Adpgk ADP-dependent glucokinase 0.33 NM_007417 Adra2a Adrenergic receptor, alpha 2a 0.26 NM_133919 Aff1 AF4/FMR2 family, member 1 0.40 NM_026203 Ahi1 Abelson helper integration site 0.37 NM_013464 Ahr Aryl-hydrocarbon receptor 0.38 NM_207219 AI314976 Expressed sequence AI314976 0.34 NM_001039220 AI429214 Expressed sequence AI429214 0.39 NM_001013770 AI747699 Expressed sequence AI747699 0.28 NM_177716 AI836003 Expressed sequence AI836003 0.37 NM_001033139 AI846148 Expressed sequence AI846148 0.27 NM_008012 Akr1b8 Aldo-keto reductase family 1, member B8 0.32 NM_030611 Akr1c6 Aldo-keto reductase family 1, member C6 0.39 NM_053080 Aldh1a3 Aldehyde dehydrogenase family 1, subfamily A3 0.30 NM_011921 Aldh1a7 Aldehyde dehydrogenase family 1, subfamily A7 0.22 Asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2- NM_183142 Alg11 mannosyltransferase) 0.37 NM_028717 Als2 Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) 0.30 NM_009666 Amelx Amelogenin X chromosome 0.38 NM_153319 Amot Angiomotin 0.24 NM_001033303 Ampd1 Adenosine monophosphate deaminase 1 (isoform M) 0.17 NM_001013814 Amt 0.25 NM_009669 Amy2 Amylase 2, pancreatic 0.30 NM_008569 Anapc1 Anaphase promoting complex subunit 1 0.38 NM_028333 Angptl1 Angiopoietin-like 1 0.29 NM_020581 Angptl4 Angiopoietin-like 4 0.40

150 NM_146033 Ankmy2 Ankyrin repeat and MYND domain containing 2 0.33 NM_026241 Ankrd39 Ankyrin repeat domain 39 0.34 NM_023210 Anp32e Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.39 NM_011922 Anxa10 Annexin A10 0.34 NM_133872 Aof2 Amine oxidase (flavin containing) domain 2 0.37 NM_009678 Ap1m2 Adaptor protein complex AP-1, mu 2 subunit 0.23 NM_009680 Ap3b1 Adaptor-related protein complex 3, beta 1 subunit 0.32 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 0.34 NM_026193 Ap4b1 Adaptor-related protein complex AP-4, beta 1 0.36 NM_007462 Apc Adenomatosis polyposis coli 0.28 NM_009696 Apoe Apolipoprotein E 0.37 NM_013475 Apoh Apolipoprotein H 0.37 NM_009700 Aqp4 Aquaporin 4 0.38 NM_009703 Araf V-raf murine sarcoma 3611 viral oncogene homolog 0.36 NM_001025377 Arhgap15 Rho GTPase activating protein 15 0.38 NM_001037727 Arhgap25 Rho GTPase activating protein 25 0.15 NM_001005508 Arhgap30 Rho GTPase activating protein 30 0.36 NM_138630 Arhgap4 Rho GTPase activating protein 4 0.37 NM_027144 Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.20 NM_001033329 Arhgef9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.39 NM_019689 Arid3b AT rich interactive domain 3B (Bright like) 0.32 NM_145996 Arid5a AT rich interactive domain 5A (Mrf1 like) 0.40 NM_011790 Arih2 Ariadne homolog 2 (Drosophila) 0.38 NM_026577 Arl13b ADP-ribosylation factor-like 13B 0.25 NM_001034858 Armc2 Armadillo repeat containing 2 0.27 NM_007489 Arntl Aryl hydrocarbon receptor nuclear translocator-like 0.37 NM_009710 Art1 ADP-ribosyltransferase 1 0.38 NM_030711 Arts1 Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator 0.40 NM_001039126 Asb1 Ankyrin repeat and SOCS box-containing protein 1 0.34 NM_026853 Asb11 Ankyrin repeat and SOCS box-containing protein 11 0.32 NM_080856 Asb14 Ankyrin repeat and SOCS box-containing protein 14 0.37 NM_080847 Asb15 Ankyrin repeat and SOCS box-containing protein 15 0.38 NM_025758 Asb17 Ankyrin repeat and SOCS box-containing protein 17 0.36 NM_023906 Asb3 Ankyrin repeat and SOCS box-containing protein 3 0.20 NM_009791 Aspm Asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.37 NM_198223 Aspscr1 Alveolar soft part sarcoma chromosome region, candidate 1 (human) 0.30 NM_027435 Atad2 ATPase family, AAA domain containing 2 0.37 NM_145387 Athl1 ATH1, acid trehalase-like 1 (yeast) 0.21 NM_001001798 Atp11c Atpase, class VI, type 11C 0.38 NM_213616 Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.40 NM_016774 Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.35 NM_175406 Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 0.29 NM_134157 Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 0.34 NM_024216 Atpbd1c ATP binding domain 1 family, member C 0.39 NM_139227 Atxn7 Ataxin 7 0.39 NM_177629 AU021034 Expressed sequence AU021034 0.20 NM_016847 Avpr1a Arginine vasopressin receptor 1A 0.27 NM_001013774 AW146299 Expressed sequence AW146299 0.39 NM_134067 AW209491 Expressed sequence AW209491 0.34 NM_145930 AW549877 Expressed sequence AW549877 0.38 NM_178737 AW551984 Expressed sequence AW551984 0.38 NM_009465 Axl AXL receptor tyrosine kinase 0.39 NM_153287 Axud1 AXIN1 up-regulated 1 0.16 NM_133359 AY026312 CDNA sequence AY026312 0.36 NM_013478 Azgp1 Alpha-2-glycoprotein 1, zinc 0.33 NM_023057 B230120H23Rik RIKEN cDNA B230120H23 gene 0.31 NM_020025 B3galt2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.36 NM_175312 B630005N14Rik RIKEN cDNA B630005N14 gene 0.18

151 NM_153539 B830045N13Rik RIKEN cDNA B830045N13 gene 0.25 NM_013863 Bag3 Bcl2-associated athanogene 3 0.38 NM_026505 Bambi BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis) 0.09 NM_001005477 Barhl2 BarH-like 2 (Drosophila) 0.30 NM_028967 Batf2 Basic leucine zipper transcription factor, ATF-like 2 0.36 NM_028284 Bbs5 Bardet-Biedl syndrome 5 (human) 0.41 NM_145964 BC002199 CDNA sequence BC002199 0.22 NM_145497 BC016495 CDNA sequence BC016495 0.29 NM_133214 BC017612 CDNA sequence BC017612 0.40 NM_145430 BC017647 CDNA sequence BC017647 0.40 NM_145549 BC020077 CDNA sequence BC020077 0.35 NM_177632 BC022623 CDNA sequence BC022623 0.39 NM_146159 BC023882 CDNA sequence BC023882 0.23 NM_199149 BC024868 CDNA sequence BC024868 0.39 NM_001033284 BC026585 CDNA sequence BC026585 0.37 NM_153557 BC029214 CDNA sequence BC029214 0.22 NM_146261 BC031748 CDNA sequence BC031748 0.40 NM_153161 BC037034 CDNA sequence BC037034 0.36 NM_177768 BC038156 CDNA sequence BC038156 0.31 NM_174848 BC043118 CDNA sequence BC043118 0.33 NM_177631 BC048502 CDNA sequence BC048502 0.21 NM_175020 BC048599 CDNA sequence BC048599 0.40 NM_001004152 BC050099 CDNA sequence BC050099 0.23 NM_145635 BC054059 CDNA sequence BC054059 0.40 NM_001001334 BC061194 CDNA sequence BC061194 0.27 NM_198667 BC061212 CDNA sequence BC061212 0.35 NM_001024721 BC094916 CDNA sequence BC094916 0.40 NM_009739 Bckdk Branched chain ketoacid dehydrogenase kinase 0.36 NM_007536 Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.37 NM_007528 Bcl6b B-cell CLL/lymphoma 6, member B 0.25 NM_021486 Bcmo1 Beta-carotene 15,15'-monooxygenase 0.27 NM_011913 Best1 0.22 NM_009052 Bex1 Brain expressed gene 1 0.33 NM_009751 Bfsp1 Beaded filament structural protein in lens-CP94 0.38 NM_001032298 Bglap2 Bone gamma-carboxyglutamate protein 2 0.39 NM_007550 Blm Bloom syndrome homolog (human) 0.38 NM_026678 Blvra Biliverdin reductase A 0.40 NM_138313 Bmf Bcl2 modifying factor 0.20 NM_007559 Bmp8b Bone morphogenetic protein 8b 0.31 NM_007563 Bpgm 2,3-bisphosphoglycerate mutase 0.19 NM_145956 Brcc3 BRCA1/BRCA2-containing complex, subunit 3 0.30 NM_144541 Bre Brain and reproductive organ-expressed protein 0.36 NM_001003920 Brsk1 BR serine/threonine kinase 1 0.22 NM_009763 Bst1 Bone marrow stromal cell antigen 1 0.27 NM_201646 Btbd6 BTB (POZ) domain containing 6 0.40 NM_145455 Btf3 Basic transcription factor 3 0.31 NM_009771 Btrc Beta-transducin repeat containing protein 0.28 NM_177233 C130034I18Rik RIKEN cDNA C130034I18 gene 0.36 NM_181323 C130090K23Rik RIKEN cDNA C130090K23 gene 0.41 NM_001002792 C230029F24Rik RIKEN cDNA C230029F24 gene 0.26 NM_207265 C230071H18Rik RIKEN cDNA C230071H18 gene 0.27 NM_145855 C330046G03Rik RIKEN cDNA C330046G03 gene 0.38 NM_009779 C3ar1 Complement component 3a receptor 1 0.40 NM_145368 C730036D15Rik RIKEN cDNA C730036D15 gene 0.35 NM_146148 C8a Complement component 8, alpha polypeptide 0.37 NM_026908 Cab39l Calcium binding protein 39-like 0.38 NM_022021 Cables1 Cdk5 and Abl enzyme substrate 1 0.38 NM_013877 Cabp5 Calcium binding protein 5 0.40

152 NM_009781 Cacna1c Calcium channel, voltage-dependent, L type, alpha 1C subunit 0.36 NM_019582 Cacna1f Calcium channel, voltage-dependent, alpha 1F subunit 0.39 NM_009786 Cacybp Calcyclin binding protein 0.23 Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and NM_023525 Cad 0.30 NM_001025600 Cadm1 Cell adhesion molecule 1 0.23 NM_178721 Cadm2 Cell adhesion molecule 2 0.30 NM_053199 Cadm3 Cell adhesion molecule 3 0.11 NM_009788 Calb1 Calbindin-28K 0.38 NM_018782 Calcrl Calcitonin receptor-like 0.40 NM_001033444 Capn13 Calpain 13 0.40 NM_007603 Capn6 Calpain 6 0.22 NM_009807 Casp1 Caspase 1 0.20 NM_007609 Casp4 Caspase 4, apoptosis-related cysteine peptidase 0.35 NM_011997 Casp8ap2 Caspase 8 associated protein 2 0.41 NM_013803 Casr Calcium-sensing receptor 0.35 NM_172633 Cbln2 Cerebellin 2 precursor protein 0.39 NM_175369 Ccdc122 Coiled-coil domain containing 122 0.31 NM_024201 Ccdc127 Coiled-coil domain containing 127 0.31 NM_138603 Ccdc22 Coiled-coil domain containing 22 0.27 NM_001033455 Ccdc27 Coiled-coil domain containing 27 0.24 NM_025455 Ccdc28b Coiled coil domain containing 28B 0.25 NM_199310 Ccdc32 Coiled-coil domain containing 32 0.32 NM_177779 Ccdc42 Coiled-coil domain containing 42 0.39 NM_025689 Ccdc51 Coiled-coil domain containing 51 0.25 NM_177759 Ccdc60 Coiled-coil domain containing 60 0.16 NM_181816 Ccdc67 Coiled-coil domain containing 67 0.29 NM_001002787 Ccin Calicin 0.40 NM_007627 Cckbr Cholecystokinin B receptor 0.34 NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 0.33 NM_011338 Ccl9 Chemokine (C-C motif) ligand 9 0.19 NM_009837 Cct4 Chaperonin subunit 4 (delta) 0.38 NM_207244 Cd200r4 Cd200 receptor 4 0.35 NM_001037800 Cd209b CD209b antigen 0.30 NM_019421 Cd320 CD320 antigen 0.34 NM_007643 Cd36 CD36 antigen 0.10 NM_009690 Cd5l CD5 antigen-like 0.14 NM_133655 Cd81 CD 81 antigen 0.38 NM_009861 Cdc42 Cell division cycle 42 homolog (S. cerevisiae) 0.38 NM_001008420 Cdh12 Cadherin 12 0.37 NM_011800 Cdh20 Cadherin 20 0.15 NM_007666 Cdh6 Cadherin 6 0.31 NM_026373 Cdk2ap2 CDK2-associated protein 2 0.41 NM_145990 Cdk5rap2 CDK5 regulatory subunit associated protein 2 0.16 NM_033037 Cdo1 1, cytosolic 0.36 NM_007673 Cdx2 Caudal type homeo box 2 0.35 NM_173762 Cenpe Centromere protein E 0.37 NM_199032 Cep135 Centrosomal protein 135 0.39 NM_028760 Cep55 Centrosomal protein 55 0.40 NM_007684 Cetn3 Centrin 3 0.20 NM_024166 Chchd2 Coiled-coil-helix-coiled-coil-helix domain containing 2 0.37 NM_025351 Chchd6 Coiled-coil-helix-coiled-coil-helix domain containing 6 0.34 NM_007691 Chek1 Checkpoint kinase 1 homolog (S. pombe) 0.31 NM_018818 Chm Choroidermia 0.29 NM_023543 Chn2 Chimerin (chimaerin) 2 0.21 NM_007698 Chrm1 Cholinergic receptor, muscarinic 1, CNS 0.28 NM_203491 Chrm2 Cholinergic receptor, muscarinic 2, cardiac 0.33 NM_033269 Chrm3 Cholinergic receptor, muscarinic 3, cardiac 0.35 NM_176844 Chrna5 Cholinergic receptor, nicotinic, alpha polypeptide 5 0.40

153 NM_175140 Chst8 Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.28 NM_007708 Cit Citron 0.34 NM_029633 Clasp2 CLIP associating protein 2 0.30 NM_022890 Cldn12 Claudin 12 0.35 NM_053241 Cldn16 Claudin 16 0.22 NM_013805 Cldn5 Claudin 5 0.20 NM_019765 Clip1 CAP-GLY domain containing linker protein 1 0.35 NM_030179 Clip4 CAP-GLY domain containing linker protein family, member 4 0.11 NM_023671 Clns1a Chloride channel, nucleotide-sensitive, 1A 0.21 NM_011802 Clpx Caseinolytic peptidase X (E.coli) 0.40 NM_001024714 Cma2 Chymase 2, mast cell 0.40 NM_009918 Cnga3 Cyclic nucleotide gated channel alpha 3 0.24 NM_001039551 Cnnm3 Cyclin M3 0.33 NM_001004357 Cntnap2 Contactin associated protein-like 2 0.38 NM_026225 Cog6 Component of oligomeric golgi complex 6 0.34 NM_173422 Colec10 Collectin sub-family member 10 0.39 NM_130449 Colec12 Collectin sub-family member 12 0.33 NM_009938 Copa Coatomer protein complex subunit alpha 0.30 NM_015827 Copb2 Coatomer protein complex, subunit beta 2 (beta prime) 0.25 NM_017478 Copg2 Coatomer protein complex, subunit gamma 2 0.29 COX10 homolog, cytochrome c oxidase assembly protein, A: NM_178379 Cox10 farnesyltransferase (yeast) 0.22 NM_199008 Cox11 COX11 homolog, cytochrome c oxidase assembly protein (yeast) 0.30 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 0.40 NM_030052 Cox7b2 Cytochrome c oxidase subunit VIIb2 0.40 NM_007752 Cp Ceruloplasmin 0.35 NM_027926 Cpa4 Carboxypeptidase A4 0.25 NM_029706 Cpb1 Carboxypeptidase B1 (tissue) 0.29 NM_013494 Cpe 0.36 NM_027769 Cpne3 Copine III 0.33 NM_007757 Cpox Coproporphyrinogen oxidase 0.29 NM_205769 Crh Corticotropin releasing hormone 0.37 NM_015800 Crim1 Cysteine rich transmembrane BMP regulator 1 (chordin like) 0.40 NM_007763 Crip1 Cysteine-rich protein 1 (intestinal) 0.41 NM_031402 Crispld1 Cysteine-rich secretory protein LCCL domain containing 1 0.33 NM_023733 Crot Carnitine O-octanoyltransferase 0.41 NM_013499 Crry Complement receptor related protein 0.17 NM_021541 Cryba2 Crystallin, beta A2 0.15 NM_011733 Csda Cold shock domain protein A 0.38 Colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte- NM_007781 Csf2rb2 macrophage) 0.40 NM_007786 Csn3 Casein kappa 0.28 NM_001033239 Csta Cystatin A 0.40 NM_024199 Cstf1 Cleavage stimulation factor, 3' pre-RNA, subunit 1 0.38 NM_028836 Ctbs Chitobiase, di-N-acetyl- 0.34 NM_021445 Cts6 Cathepsin 6 0.23 NM_009982 Ctsc Cathepsin C 0.38 NM_019861 Ctsf Cathepsin F 0.31 NM_012007 Ctsj Cathepsin J 0.12 NM_198013 Cuedc1 CUE domain containing 1 0.13 NM_008411 Cuzd1 CUB and zona pellucida-like domains 1 0.25 NM_027545 Cwf19l2 CWF19-like 2, cell cycle control (S. pombe) 0.37 NM_021274 Cxcl10 Chemokine (C-X-C motif) ligand 10 0.24 NM_018866 Cxcl13 Chemokine (C-X-C motif) ligand 13 0.24 NM_011339 Cxcl15 Chemokine (C-X-C motif) ligand 15 0.35 NM_009911 Cxcr4 Chemokine (C-X-C motif) receptor 4 0.28 NM_009997 Cyp2a4 Cytochrome P450, family 2, subfamily a, polypeptide 4 0.36 NM_007812 Cyp2a5 Cytochrome P450, family 2, subfamily a, polypeptide 5 0.38 NM_145474 Cyp2d34 Cytochrome P450, family 2, subfamily d, polypeptide 34 0.32

154 NM_028775 Cyp2s1 Cytochrome P450, family 2, subfamily s, polypeptide 1 0.36 NM_007823 Cyp4b1 Cytochrome P450, family 4, subfamily b, polypeptide 1 0.27 NM_144853 Cyyr1 Cysteine and tyrosine-rich protein 1 0.39 NM_172625 D030070L09Rik RIKEN cDNA D030070L09 gene 0.30 NM_145462 D14Ertd500e DNA segment, Chr 14, ERATO Doi 500, expressed 0.37 NM_199015 D14Ertd668e DNA segment, Chr 14, ERATO Doi 668, expressed 0.32 NM_146099 D19Wsu162e DNA segment, Chr 19, Wayne State University 162, expressed 0.41 NM_178752 D330012F22Rik RIKEN cDNA D330012F22 gene 0.36 NM_172727 D330028D13Rik RIKEN cDNA D330028D13 gene 0.35 NM_172737 D430041B17Rik RIKEN cDNA D430041B17 gene 0.34 NM_178727 D630039A03Rik RIKEN cDNA D630039A03 gene 0.41 NM_172921 D930028F11Rik RIKEN cDNA D930028F11 gene 0.31 NM_022994 Dap3 Death associated protein 3 0.35 NM_010019 Dapk2 Death-associated kinase 2 0.26 NM_145507 Dars Aspartyl-tRNA synthetase 0.23 NM_019813 Dbn1 Drebrin 1 0.39 NM_134040 Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.36 NM_152806 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.31 NM_026500 Ddx59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 0.36 NM_139225 Defb10 Defensin beta 10 0.29 NM_139224 Defb35 Defensin beta 35 0.37 NM_199067 Defb50 Defensin beta 50 0.32 NM_183217 Dennd1b DENN/MADD domain containing 1B 0.37 NM_001025426 Depdc5 DEP domain containing 5 0.25 NM_177914 Dgkk Diacylglycerol kinase kappa 0.38 NM_027790 Dhrs2 Dehydrogenase/reductase member 2 0.35 NM_172594 Dhx29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.18 NM_175551 Dido1 Death inducer-obliterator 1 0.17 NM_172819 Dip2b DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.34 NM_007862 Dlg1 Discs, large homolog 1 (Drosophila) 0.39 NM_016779 Dmp1 Dentin matrix protein 1 0.14 NM_177360 Dmrt3 Doublesex and mab-3 related transcription factor 3 0.41 NM_027732 Dmrtc2 Doublesex and mab-3 related transcription factor like family C2 0.40 NM_177372 Dna2l DNA2 DNA replication helicase 2-like (yeast) 0.35 NM_175138 Dnaic1 Dynein, axonemal, intermediate chain 1 0.37 NM_026400 Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.18 NM_011847 Dnajb6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.33 NM_021317 Dnajb7 DnaJ (Hsp40) homolog, subfamily B, member 7 0.40 NM_024181 Dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.32 NM_029669 Dnajc18 DnaJ (Hsp40) homolog, subfamily C, member 18 0.40 NM_198412 Dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.19 NM_173383 Dnd1 Dead end homolog 1 (zebrafish) 0.39 NM_001038619 Dnm3 Dynamin 3 0.32 NM_153413 Dock3 Dedicator of cyto-kinesis 3 0.31 NM_053246 Dok4 Docking protein 4 0.40 NM_029761 Dok5 Docking protein 5 0.36 NM_028615 Dppa2 Developmental pluripotency associated 2 0.41 NM_001018002 Dppa4 Developmental pluripotency associated 4 0.32 NM_007878 Drd4 Dopamine receptor 4 0.19 NM_007879 Drg1 Developmentally regulated GTP binding protein 1 0.41 NM_013505 Dsc2 Desmocollin 2 0.38 NM_181682 Dsg1b Desmoglein 1 beta 0.39 NM_181680 Dsg1c Desmoglein 1 gamma 0.33 NM_007883 Dsg2 Desmoglein 2 0.31 NM_133833 Dst Dystonin 0.31 NM_175118 Dusp28 Dual specificity phosphatase 28 0.38 NM_010064 Dync1i2 Dynein cytoplasmic 1 intermediate chain 2 0.39 NM_029851 Dync2h1 Dynein cytoplasmic 2 heavy chain 1 0.37

155 NM_001039556 E130016E03Rik RIKEN cDNA E130016E03 gene 0.38 NM_001038651 E130120F12Rik RIKEN cDNA E130120F12 gene 0.27 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 0.15 NM_178668 E430028B21Rik RIKEN cDNA E430028B21 gene 0.31 NM_028932 Eaf1 ELL associated factor 1 0.31 NM_007894 Ear1 Eosinophil-associated, ribonuclease A family, member 1 0.19 NM_007895 Ear2 Eosinophil-associated, ribonuclease A family, member 2 0.29 NM_138302 Ecgf1 Endothelial cell growth factor 1 (platelet-derived) 0.29 NM_025855 Echdc1 Enoyl Coenzyme A hydratase domain containing 1 0.32 NM_001012324 Ecm2 Extracellular matrix protein 2, female organ and adipocyte specific 0.38 NM_010100 Edar Ectodysplasin-A receptor 0.26 NM_172504 EG212225 Predicted gene, EG212225 0.31 NM_174999 EG215472 Predicted gene, EG215472 0.32 NM_177706 EG237300 Predicted gene, EG237300 0.35 NM_001013760 EG238829 Predicted gene, EG238829 0.25 NM_001033767 EG240327 Predicted gene, EG240327 0.41 NM_001013762 EG240549 Predicted gene, EG240549 0.26 NM_183309 EG330305 Predicted gene, EG330305 0.39 NM_001033540 EG330503 Predicted gene, EG330503 0.37 NM_183320 EG331529 Predicted gene, EG331529 0.24 NM_198657 EG381438 Predicted gene, EG381438 0.35 NM_001037248 EG381936 Predicted gene, EG381936 0.30 NM_001025240 EG384813 Predicted gene, EG384813 0.36 NM_001034883 EG432982 Predicted gene, EG432982 0.36 NM_001039218 EG433178 Predicted gene, EG433178 0.20 NM_001037167 EG434881 Predicted gene, EG434881 0.39 NM_001034894 EG436240 Predicted gene, EG436240 0.36 NM_001034906 EG547109 Predicted gene, EG547109 0.36 NM_001037924 EG625321 Predicted gene, EG625321 0.40 NM_001037931 EG628416 Predicted gene, EG628416 0.21 NM_001037935 EG629678 Predicted gene, EG629678 0.41 NM_001039244 EG633640 Predicted gene, EG633640 0.35 NM_001039125 EG654465 Predicted gene, EG654465 0.35 NM_010113 Egf Epidermal growth factor 0.40 NM_178748 Egflam EGF-like, fibronectin type III and laminin G domains 0.34 NM_007914 Ehf Ets homologous factor 0.40 NM_023737 Ehhadh Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 0.40 NM_013719 Eif2ak4 Eukaryotic translation initiation factor 2 alpha kinase 4 0.37 NM_153403 Eif2c1 Eukaryotic translation initiation factor 2C, 1 0.37 NM_153402 Eif2c3 Eukaryotic translation initiation factor 2C, 3 0.41 NM_025344 Eif3f Eukaryotic translation initiation factor 3, subunit F 0.16 NM_010579 Eif6 Eukaryotic translation initiation factor 6 0.37 NM_023479 Elac2 ElaC homolog 2 (E. coli) 0.33 NM_023502 Elf2 E74-like factor 2 0.19 NM_029001 Elovl7 ELOVL family member 7, elongation of long chain fatty acids (yeast) 0.41 NM_028811 Elp3 Elongation protein 3 homolog (S. cerevisiae) 0.18 NM_016885 Emcn Endomucin 0.26 NM_199466 Eml4 Echinoderm microtubule associated protein like 4 0.37 NM_139138 Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.32 NM_017468 Enam Enamelin 0.37 NM_028013 Endod1 Endonuclease domain containing 1 0.39 NM_001025388 Eno1 Enolase 1, alpha non-neuron 0.25 NM_023119 Eno1 Enolase 1, alpha non-neuron 0.38 NM_013509 Eno2 , gamma neuronal 0.36 NM_013512 Epb4.1l4a Erythrocyte protein band 4.1-like 4a 0.28 NM_010140 Epha3 Eph receptor A3 0.30 NM_010143 Ephb3 Eph receptor B3 0.32 NM_007884 Epyc Epiphycan 0.35

156 Excision repair cross-complementing rodent repair deficiency, complementation NM_011729 Ercc5 group 5 0.39 NM_026168 Ergic2 ERGIC and golgi 2 0.36 NM_015774 Ero1l ERO1-like (S. cerevisiae) 0.41 NM_007954 Es1 Esterase 1 0.38 NM_145615 Etfa Electron transferring flavoprotein, alpha polypeptide 0.36 NM_007960 Etv1 Ets variant gene 1 0.28 NM_012012 Exo1 Exonuclease 1 0.38 NM_019393 Exosc9 Exosome component 9 0.37 NM_018788 Extl3 Exostoses (multiple)-like 3 0.25 NM_010164 Eya1 Eyes absent 1 homolog (Drosophila) 0.27 NM_210071 Eya3 Eyes absent 3 homolog (Drosophila) 0.41 NM_031164 Coagulation factor XIII, beta subunit 0.38 NM_007977 F8 Coagulation factor VIII 0.30 NM_007980 Fabp2 Fatty acid binding protein 2, intestinal 0.41 NM_010634 Fabp5 Fatty acid binding protein 5, epidermal 0.36 NM_011810 Faim Fas apoptotic inhibitory molecule 0.37 NM_026210 Fam18b Family with sequence similarity 18, member B 0.28 NM_175027 Fancb Fanconi anemia, complementation group B 0.35 NM_053081 Fancg Fanconi anemia, complementation group G 0.28 NM_011811 Farsb Phenylalanyl-tRNA synthetase, beta subunit 0.38 NM_172422 Fastkd2 FAST kinase domains 2 0.19 NM_133694 Fbxl15 F-box and leucine-rich repeat protein 15 0.30 NM_001033156 Fbxo33 F-box protein 33 0.29 NM_013907 Fbxw4 F-box and WD-40 domain protein 4 0.31 NM_172721 Fbxw8 F-box and WD-40 domain protein 8 0.31 NM_144960 Fcamr Fc receptor, IgA, IgM, high affinity 0.33 NM_010184 Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide 0.35 NM_001037997 Fert2 Fer (fms/fps related) protein kinase, testis specific 2 0.17 NM_026218 Fgfr1op2 FGFR1 oncogene partner 2 0.30 NM_010207 Fgfr2 Fibroblast growth factor receptor 2 0.24 NM_145594 Fgl1 Fibrinogen-like protein 1 0.24 NM_153573 Fkbp14 FK506 binding protein 14 0.41 NM_012056 Fkbp9 FK506 binding protein 9 0.32 NM_146018 Flcn Folliculin 0.33 NM_001040403 Flot2 Flotillin 2 0.39 NM_018881 Fmo2 Flavin containing monooxygenase 2 0.31 NM_008030 Fmo3 Flavin containing monooxygenase 3 0.29 NM_172844 Fmo9 Flavin containing monooxygenase 9 0.33 NM_153118 Fnbp1l Formin binding protein 1-like 0.26 NM_212435 Foxp2 Forkhead box P2 0.41 NM_145583 Frag1 FGF receptor activating protein 1 0.20 NM_177136 Fryl Furry homolog-like (Drosophila) 0.26 NM_010239 Fth1 Ferritin heavy chain 1 0.36 NM_011936 Fto Fat mass and obesity associated 0.20 NM_011815 Fyb FYN binding protein 0.40 NM_008054 Fyn Fyn proto-oncogene 0.39 NM_021457 Fzd1 Frizzled homolog 1 (Drosophila) 0.40 NM_008058 Fzd8 Frizzled homolog 8 (Drosophila) 0.15 NM_201638 G430022H21Rik RIKEN cDNA G430022H21 gene 0.29 NM_008076 Gabrr2 Gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2 0.40 NM_030165 Galnact2 Chondroitin sulfate GalNAcT-2 0.36 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_013814 Galnt1 acetylgalactosaminyltransferase 1 0.22 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_030166 Galntl2 acetylgalactosaminyltransferase-like 2 0.31 NM_001033331 Gas2l3 Growth arrest-specific 2 like 3 0.37 NM_139304 Gatad2b GATA zinc finger domain containing 2B 0.19 NM_030719 Gats Opposite strand transcription unit to Stag3 0.16

157 NM_139197 Gbgt1 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 0.36 NM_010259 Gbp1 Guanylate nucleotide binding protein 1 0.29 NM_027045 Gcap14 Granule cell antiserum positive 14 0.33 NM_008129 Gclm Glutamate-cysteine ligase , modifier subunit 0.39 NM_026053 Gemin6 Gem (nuclear organelle) associated protein 6 0.24 NM_138591 Gfm1 G elongation factor, mitochondrial 1 0.39 NM_205844 Gfral GDNF family receptor alpha like 0.12 NM_010281 Ggh Gamma-glutamyl hydrolase 0.40 NM_008376 Gimap1 GTPase, IMAP family member 1 0.41 NM_146167 Gimap7 GTPase, IMAP family member 7 0.40 NM_030198 Gins3 GINS complex subunit 3 (Psf3 homolog) 0.38 NM_010288 Gja1 Gap junction membrane channel protein alpha 1 0.29 NM_008127 Gjb4 Gap junction membrane channel protein beta 4 0.39 NM_008128 Gjb6 Gap junction membrane channel protein beta 6 0.40 NM_025467 Gkn2 Gastrokine 2 0.23 NM_133236 Glcci1 Glucocorticoid induced transcript 1 0.35 NM_138595 Gldc Glycine decarboxylase 0.33 NM_029102 Glt8d2 Glycosyltransferase 8 domain containing 2 0.40 NM_153601 Gluld1 Glutamate-ammonia ligase (glutamine synthetase) domain containing 1 0.39 NM_008134 Glycam1 Glycosylation dependent cell adhesion molecule 1 0.35 NM_001013749 Gm323 Gene model 323, (NCBI) 0.40 NM_001029889 Gm608 Gene model 608, (NCBI) 0.39 NM_001033252 Gm732 Gene model 732, (NCBI) 0.25 NM_203508 Gm75 Gene model 75, (NCBI) 0.31 NM_001033407 Gm815 Gene model 815, (NCBI) 0.17 NM_001033434 Gm884 Gene model 884, (NCBI) 0.34 NM_001033283 Gm97 Gene model 97, (NCBI) 0.40 NM_011818 Gmcl1 Germ cell-less homolog 1 (Drosophila) 0.33 NM_008137 Gna14 Guanine nucleotide binding protein, alpha 14 0.34 Guanine nucleotide binding protein (G protein), gamma transducing activity NM_010314 Gngt1 polypeptide 1 0.39 NM_029793 Golga1 Golgi autoantigen, golgin subfamily a, 1 0.35 NM_020585 Golga7 Golgi autoantigen, golgin subfamily a, 7 0.37 NM_027352 Gorasp2 Golgi reassembly stacking protein 2 0.23 NM_028487 Gpbp1 GC-rich promoter binding protein 1 0.34 NM_010274 Gpd2 Glycerol phosphate dehydrogenase 2, mitochondrial 0.34 NM_001033360 Gpr101 G protein-coupled receptor 101 0.39 NM_198192 Gpr103 G protein-coupled receptor 103 0.22 NM_008159 Gpr33 G protein-coupled receptor 33 0.21 NM_022320 Gpr35 G protein-coupled receptor 35 0.37 NM_008152 Gpr65 G-protein coupled receptor 65 0.38 NM_176912 Gpr77 G protein-coupled receptor 77 0.38 NM_053118 Gprc5d G protein-coupled receptor, family C, group 5, member D 0.18 NM_030677 Gpx2 Glutathione peroxidase 2 0.23 NM_015764 Greb1 Gene regulated by estrogen in breast cancer protein 0.41 NM_178602 Grinl1a Glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A 0.25 NM_177379 Grit Rho GTPase-activating protein 0.25 NM_181850 Grm3 Glutamate receptor, metabotropic 3 0.23 NM_026764 Gstm4 Glutathione S-transferase, mu 4 0.24 NM_010360 Gstm5 Glutathione S-transferase, mu 5 0.39 NM_181410 Gtf2h3 General transcription factor IIH, polypeptide 3 0.30 NM_025294 Gtlf3b Gene trap locus F3b 0.34 NM_181424 Gtpbp5 GTP binding protein 5 0.39 NM_025332 Gtpbp8 GTP-binding protein 8 (putative) 0.34 NM_013882 Gtse1 G two S phase expressed protein 1 0.35 NM_008189 Guca1a Guanylate cyclase activator 1a (retina) 0.37 NM_013542 Gzmb Granzyme B 0.22 NM_010381 H2-Ea Histocompatibility 2, class II antigen E alpha 0.30 NM_010382 H2-Eb1 Histocompatibility 2, class II antigen E beta 0.38

158 NM_019986 Habp4 Hyaluronic acid binding protein 4 0.35 NM_134248 Havcr1 Hepatitis A virus cellular receptor 1 0.40 NM_134250 Havcr2 Hepatitis A virus cellular receptor 2 0.41 NM_153198 Hbp1 High mobility group box transcription factor 1 0.33 NM_008231 Hdgf Hepatoma-derived growth factor 0.27 NM_026108 Hdhd1a Haloacid dehalogenase-like hydrolase domain 0.40 NM_024257 Hdhd3 Haloacid dehalogenase-like hydrolase domain containing 3 0.41 NM_028705 Herc3 Hect domain and RLD 3 0.41 NM_008246 Hiat1 Hippocampus abundant gene transcript 1 0.40 NM_178922 Hic2 Hypermethylated in cancer 2 0.40 NM_016868 Hif3a Hypoxia inducible factor 3, alpha subunit 0.39 NM_025798 Hint3 Histidine triad nucleotide binding protein 3 0.40 NM_010434 Hipk3 Homeodomain interacting protein kinase 3 0.27 NM_173760 Hisppd1 Histidine acid phosphatase domain containing 1 0.34 NM_175661 Hist1h2af Histone cluster 1, H2af 0.32 NM_178196 Hist1h2bg Histone cluster 1, H2bg 0.31 NM_178202 Hist1h2bp Histone cluster 1, H2bp 0.39 NM_178192 Hist1h4a Histone cluster 1, H4a 0.32 NM_153173 Hist1h4h Histone cluster 1, H4h 0.34 NM_178211 Hist1h4k Histone cluster 1, H4k 0.33 NM_008251 Hmgn1 High mobility group nucleosomal binding domain 1 0.21 NM_029804 Hnrpm Heterogeneous nuclear ribonucleoprotein M 0.39 NM_178089 Hnrpul1 Heterogeneous nuclear ribonucleoprotein U-like 1 0.25 NM_172290 Hnt Neurotrimin 0.27 NM_010450 Hoxa11 Homeo box A11 0.38 NM_010456 Hoxa9 Homeo box A9 0.29 NM_010460 Hoxb7 Homeo box B7 0.30 NM_010462 Hoxc10 Homeo box C10 0.36 NM_010467 Hoxd1 Homeo box D1 0.35 NM_013554 Hoxd10 Homeo box D10 0.32 NM_010469 Hoxd4 Homeo box D4 0.41 NM_010470 Hp1bp3 Heterochromatin protein 1, binding protein 3 0.29 NM_153087 Hrh4 Histamine H4 receptor 0.33 NM_018805 Hs3st3b1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 0.39 NM_053262 Hsd17b11 Hydroxysteroid (17-beta) dehydrogenase 11 0.34 NM_008294 Hsd3b4 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 0.38 NM_026601 Hyi Hydroxypyruvate isomerase homolog (E. coli) 0.31 NM_172015 Iars Isoleucine-tRNA synthetase 0.34 NM_017480 Icos Inducible T-cell co-stimulator 0.36 NM_177960 Idi1 Isopentenyl-diphosphate delta isomerase 0.37 NM_028968 Ifitm7 Interferon induced transmembrane protein 7 0.36 NM_010508 Ifnar1 Interferon (alpha and beta) receptor 1 0.32 NM_183335 Igsf1 Immunoglobulin superfamily, member 1 0.36 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 0.39 NM_021792 Iigp1 Interferon inducible GTPase 1 0.27 Inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex- NM_026079 Ikbkap associated protein 0.29 NM_010546 Ikbkb Inhibitor of kappaB kinase beta 0.23 NM_011770 Ikzf2 IKAROS family zinc finger 2 0.24 NM_145856 Il17f Interleukin 17F 0.31 NM_008366 Il2 Interleukin 2 0.32 NM_172786 Il20ra Interleukin 20 receptor, alpha 0.24 NM_021887 Il21r Interleukin 21 receptor 0.34 NM_053095 Il24 Interleukin 24 0.16 NM_080729 Il25 0.29 NM_054079 Iltifb Interleukin 10-related T cell-derived inducible factor beta 0.41 NM_173751 Ilvbl IlvB (bacterial acetolactate synthase)-like 0.13 NM_028260 Immp1l IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.25 NM_177730 Impad1 Inositol monophosphatase domain containing 1 0.28

159 NM_011830 Impdh2 Inosine 5'-phosphate dehydrogenase 2 0.34 NM_022016 Impg1 Interphotoreceptor matrix proteoglycan 1 0.38 NM_001005784 Inadl InaD-like (Drosophila) 0.38 NM_011919 Ing1 Inhibitor of growth family, member 1 0.31 NM_008380 Inhba Inhibin beta-A 0.30 NM_033134 Inpp5e Inositol polyphosphate-5-phosphatase E 0.35 NM_013754 Insl6 Insulin-like 6 0.24 NM_178632 Ints7 Integrator complex subunit 7 0.17 NM_133934 Isy1 ISY1 splicing factor homolog (S. cerevisiae) 0.33 NM_008398 Itga7 0.20 NM_001029872 Itgad Integrin, alpha D 0.37 NM_016780 Itgb3 Integrin beta 3 0.27 NM_173441 Iws1 IWS1 homolog (S. cerevisiae) 0.38 NM_026365 Jagn1 Jagunal homolog 1 (Drosophila) 0.41 NM_021310 Jmy Junction-mediating and regulatory protein 0.29 NM_027721 Katnal2 Katanin p60 subunit A-like 2 0.27 NM_026962 Kbtbd3 Kelch repeat and BTB (POZ) domain containing 3 0.31 NM_019715 Kcmf1 Potassium channel modulatory factor 1 0.23 NM_010596 Kcna7 Potassium voltage-gated channel, shaker-related subfamily, member 7 0.33 NM_010597 Kcnab1 Potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.26 NM_001039347 Kcnd3 Potassium voltage-gated channel, Shal-related family, member 3 0.31 NM_030265 Kcnip4 Kv channel interacting protein 4 0.31 NM_008425 Kcnj2 Potassium inwardly-rectifying channel, subfamily J, member 2 0.18 NM_008429 Kcnj9 Potassium inwardly-rectifying channel, subfamily J, member 9 0.28 NM_029911 Kcnk10 Potassium channel, subfamily K, member 10 0.34 Potassium intermediate/small conductance calcium-activated channel, subfamily NM_080466 Kcnn3 N, member 3 0.33 NM_008438 Kera 0.31 NM_011317 Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 0.38 NM_008446 Kif4 Kinesin family member 4 0.30 NM_026324 Kirrel3 Kin of IRRE like 3 (Drosophila) 0.41 NM_009769 Klf5 Kruppel-like factor 5 0.26 NM_011803 Klf6 Kruppel-like factor 6 0.33 NM_033563 Klf7 Kruppel-like factor 7 (ubiquitous) 0.41 NM_010647 Klra12 Killer cell lectin-like receptor subfamily A, member 12 0.40 NM_008464 Klra19 Killer cell lectin-like receptor, subfamily A, member 19 0.41 NM_008526 Klrb1d Killer cell lectin-like receptor subfamily B member 1D 0.34 NM_010654 Klrd1 Killer cell lectin-like receptor, subfamily D, member 1 0.33 NM_178610 Krr1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.16 NM_001033397 Krt26 Keratin 26 0.40 NM_010659 Krt31 Keratin 31 0.23 NM_010669 Krt6b 0.30 NM_033073 Krt7 0.39 NM_212487 Krt78 Keratin 78 0.25 NM_025524 Krtap3-3 Keratin associated protein 3-3 0.30 NM_010676 Krtap8-2 Keratin associated protein 8-2 0.19 NM_029571 Kti12 KTI12 homolog, chromatin associated (S. cerevisiae) 0.34 NM_027552 Kynu Kynureninase (L-kynurenine hydrolase) 0.17 NM_010679 Lalba Lactalbumin, alpha 0.31 NM_027448 Lca5 Leber congenital amaurosis 5 (human) 0.35 NM_025984 Lce1a1 Late cornified envelope 1A1 0.26 NM_026335 Lce1h Late cornified envelope 1H 0.41 NM_033175 Lce3c Late cornified envelope 3C 0.28 NM_172154 Lcor Ligand dependent nuclear receptor corepressor 0.40 NM_010701 Lect1 Leukocyte cell derived chemotaxin 1 0.40 NM_027203 Leng1 Leukocyte receptor cluster (LRC) member 1 0.39 NM_175529 Leng9 Leukocyte receptor cluster (LRC) member 9 0.39 NM_019782 Lepre1 Leprecan 1 0.22 NM_173379 Leprel1 Leprecan-like 1 0.17

160 NM_008495 Lgals1 Lectin, galactose binding, soluble 1 0.39 NM_011175 Lgmn Legumain 0.39 NM_010709 Lgtn Ligatin 0.33 Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM NM_011095 Lilrb3 domains), member 3 0.35 NM_026334 Lipf Lipase, gastric 0.35 NM_025681 Lix1 Limb expression 1 homolog (chicken) 0.27 NM_027133 Lnp Limb and neural patterns 0.27 NM_177187 LOC100041354 Similar to D5Ertd577e protein 0.41 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 0.33 NM_022882 Lpin2 Lipin 2 0.21 NM_173418 Lrit2 Leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 0.39 NM_001033461 Lrrc43 Leucine rich repeat containing 43 0.36 NM_178678 Lrrtm3 Leucine rich repeat transmembrane neuronal 3 0.36 NM_025520 Lsm5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.18 NM_175364 Lyrm2 LYR motif containing 2 0.32 NM_010748 Lyst Lysosomal trafficking regulator 0.27 NM_027985 Mad2l2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.35 NM_020016 Magea2 Melanoma antigen, family A, 2 0.40 NM_020017 Magea3 Melanoma antigen, family A, 3 0.29 NM_053201 Magee1 Melanoma antigen, family E, 1 0.40 NM_027288 Manba Mannosidase, beta A, lysosomal 0.41 NM_026345 Mansc1 MANSC domain containing 1 0.34 NM_016693 Map3k6 Mitogen-activated protein kinase kinase kinase 6 0.35 NM_172688 Map3k7 Mitogen activated protein kinase kinase kinase 7 0.37 NM_008279 Map4k1 Mitogen activated protein kinase kinase kinase kinase 1 0.33 NM_009006 Map4k2 Mitogen activated protein kinase kinase kinase kinase 2 0.34 NM_013931 Mapk8ip3 Mitogen-activated protein kinase 8 interacting protein 3 0.30 NM_010766 Marco Macrophage receptor with collagenous structure 0.37 NM_176808 Mcfd2 Multiple coagulation factor deficiency 2 0.40 NM_008563 Mcm3 Minichromosome maintenance deficient 3 (S. cerevisiae) 0.23 NM_173189 Mcph1 Microcephaly, primary autosomal recessive 1 0.27 NM_008570 Mcpt1 Mast cell protease 1 0.30 NM_008575 Mdm4 Transformed mouse 3T3 cell double minute 4 0.32 NM_025297 Mecr Mitochondrial trans-2-enoyl-CoA reductase 0.23 NM_021521 Med12 Mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) 0.26 NM_025885 Med19 Mediator of RNA polymerase II transcription, subunit 19 homolog (yeast) 0.15 NM_025895 Med28 Mediator of RNA polymerase II transcription, subunit 28 homolog (yeast) 0.28 NM_008586 Mep1b Meprin 1 beta 0.30 NM_008591 Met Met proto-oncogene 0.40 Antigen p97 (melanoma associated) identified by monoclonal 133.2 NM_013900 Mfi2 and 96.5 0.29 NM_173870 Mgat4a Mannoside acetylglucosaminyltransferase 4, isoenzyme A 0.39 NM_010796 Mgl1 Macrophage galactose N-acetyl-galactosamine specific lectin 1 0.33 NM_019946 Mgst1 Microsomal glutathione S-transferase 1 0.39 NM_010797 Mid1 Midline 1 0.32 NM_001039081 Mier1 Mesoderm induction early response 1 homolog (Xenopus laevis 0.23 Myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog NM_027326 Mllt3 (Drosophila) 0.23 Myeloid/lymphoid or mixed lineage-leukemia translocation to 6 homolog NM_139311 Mllt6 (Drosophila) 0.39 NM_008605 Mmp12 Matrix metallopeptidase 12 0.32 NM_001030289 Mmp27 Matrix metallopeptidase 27 0.24 NM_008611 Mmp8 Matrix metallopeptidase 8 0.22 NM_029797 Mnd1 Meiotic nuclear divisions 1 homolog (S. cerevisiae) 0.25 NM_198162 Morc2a Microrchidia 2A 0.15 NM_008209 Mr1 Major histocompatibility complex, class I-related 0.34 NM_008625 Mrc1 Mannose receptor, C type 1 0.30 NM_153524 Mrgpra4 MAS-related GPR, member A4 0.40 NM_053161 Mrpl27 Mitochondrial ribosomal protein L27 0.25

161 NM_053159 Mrpl3 Mitochondrial ribosomal protein L3 0.33 NM_025796 Mrpl33 Mitochondrial ribosomal protein L33 0.29 NM_030116 Mrpl9 Mitochondrial ribosomal protein L9 0.35 NM_080452 Mrps2 Mitochondrial ribosomal protein S2 0.39 NM_021718 Ms4a4b Membrane-spanning 4-domains, subfamily A, member 4B 0.32 NM_027836 Ms4a7 Membrane-spanning 4-domains, subfamily A, member 7 0.40 NM_177092 Msrb3 Methionine sulfoxide reductase B3 0.20 NM_013601 Msx2 Homeo box, msh-like 2 0.19 NM_173013 Mtap1s Microtubule-associated protein 1S 0.40 NM_134092 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein 0.28 NM_019758 Mtch2 Mitochondrial carrier homolog 2 (C. elegans) 0.27 NM_026182 Mtfr1 Mitochondrial fission regulator 1 0.32 NM_199301 Mtg1 Mitochondrial GTPase 1 homolog (S. cerevisiae) 0.25 NM_133767 Mtif2 Mitochondrial translational initiation factor 2 0.21 NM_029581 Mtif3 Mitochondrial translational initiation factor 3 0.19 NM_028860 Mtmr3 Myotubularin related protein 3 0.26 NM_008642 Mttp Microsomal triglyceride transfer protein 0.35 NM_008646 Mug2 Murinoglobulin 2 0.27 NM_021508 Myoz1 Myozenin 1 0.39 NM_013792 Naglu Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) 0.35 NM_025898 Napa N-ethylmaleimide sensitive fusion protein attachment protein alpha 0.26 NM_008437 Napsa Napsin A aspartic peptidase 0.33 NM_134094 Ncald Neurocalcin delta 0.37 NM_031186 Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 0.29 NM_023202 Ndufa7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) 0.37 NM_026612 Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 0.30 NM_001033305 Ndufb6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 0.28 NM_023172 Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 0.26 NM_010892 Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.23 NM_016720 Neu3 Neuraminidase 3 0.23 NM_199465 Nexn Nexilin 0.33 NM_021504 Ngly1 N-glycanase 1 0.30 NM_028946 Nhedc1 Na+/H+ exchanger domain containing 1 0.32 NM_025811 Nhlrc2 NHL repeat containing 2 0.24 NM_007524 Nkx3-2 NK3 homeobox 2 0.35 NM_001033367 Nlrc4 NLR family, CARD domain containing 4 0.26 NM_001004142 Nlrp1a NLR family, pyrin domain containing 1A 0.40 NM_001004194 Nlrp4e NLR family, pyrin domain containing 4E 0.38 NM_178420 Nlrx1 NLR family member X1 0.31 NM_133787 Nmd3 NMD3 homolog (S. cerevisiae) 0.14 NM_001011684 Nms Neuromedin S 0.33 NM_019515 Nmu Neuromedin U 0.33 NM_001008421 Nol10 Nucleolar protein 10 0.17 NM_008716 Notch3 Notch gene homolog 3 (Drosophila) 0.37 NM_008720 Npc1 Niemann Pick type C1 0.27 NM_008942 Npepps Aminopeptidase puromycin sensitive 0.32 NM_016902 Nphp1 Nephronophthisis 1 (juvenile) homolog (human) 0.35 NM_175678 Npsr1 Neuropeptide S receptor 1 0.37 NM_021892 Npvf Neuropeptide VF precursor 0.35 NM_010935 Npy6r Neuropeptide Y receptor Y6 0.12 NM_198658 Nr1h5 Nuclear receptor subfamily 1, group H, member 5 0.34 NM_015743 Nr4a3 Nuclear receptor subfamily 4, group A, member 3 0.40 NM_001036293 Nrbf2 Nuclear receptor binding factor 2 0.36 NM_022029 Nrgn Neurogranin 0.20 NM_013724 Nrk Nik related kinase 0.41 NM_016710 Nsbp1 Nucleosome binding protein 1 0.36 NM_010941 Nsdhl NAD(P) dependent steroid dehydrogenase-like 0.36 NM_026746 Nsmce2 Non-SMC element 2 homolog (MMS21, S. cerevisiae) 0.11

162 NM_008743 Nthl1 Nth (endonuclease III)-like 1 (E.coli) 0.23 NM_026023 Nudcd2 NudC domain containing 2 0.36 NM_133947 Numa1 Nuclear mitotic apparatus protein 1 0.33 NM_010949 Numb Numb gene homolog (Drosophila) 0.40 NM_183392 Nup54 Nucleoporin 54 0.24 NM_001003914 Obscn Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.32 NM_011858 Odz4 Odd Oz/ten-m homolog 4 (Drosophila) 0.40 NM_146050 Oit1 Oncoprotein induced transcript 1 0.27 NM_146921 Olfr1 Olfactory receptor 1 0.27 NM_206822 Olfr10 Olfactory receptor 10 0.34 NM_001011721 Olfr100 Olfactory receptor 100 0.36 NM_146573 Olfr1002 Olfactory receptor 1002 0.25 NM_207149 Olfr1010 Olfactory receptor 1010 0.21 NM_146762 Olfr1013 Olfactory receptor 1013 0.37 NM_146569 Olfr1014 Olfactory receptor 1014 0.40 NM_146587 Olfr1023 Olfactory receptor 1023 0.32 NM_001011783 Olfr104 Olfactory receptor 104 0.15 NM_001011771 Olfr1089 Olfactory receptor 1089 0.39 NM_146365 Olfr1094 Olfactory receptor 1094 0.39 NM_146328 Olfr110 Olfactory receptor 110 0.25 NM_146752 Olfr1106 Olfactory receptor 1106 0.36 NM_001005485 Olfr111 Olfactory receptor 111 0.27 NM_147031 Olfr1122 Olfactory receptor 1122 0.35 NM_001011836 Olfr1129 Olfactory receptor 1129 0.37 NM_146640 Olfr1153 Olfactory receptor 1153 0.35 NM_146643 Olfr1155 Olfactory receptor 1155 0.36 NM_146648 Olfr1165 Olfactory receptor 1165 0.38 NM_146650 Olfr1166 Olfactory receptor 1166 0.33 NM_146917 Olfr1179 Olfactory receptor 1179 0.34 NM_207567 Olfr1198 Olfactory receptor 1198 0.35 NM_146462 Olfr1202 Olfactory receptor 1202 0.28 NM_146463 Olfr1204 Olfactory receptor 1204 0.36 NM_207140 Olfr1212 Olfactory receptor 1212 0.36 NM_146897 Olfr1214 Olfactory receptor 1214 0.38 NM_146967 Olfr1226 Olfactory receptor 1226 0.41 NM_146972 Olfr1233 Olfactory receptor 1233 0.41 NM_146968 Olfr1242 Olfactory receptor 1242 0.30 NM_146788 Olfr1245 Olfactory receptor 1245 0.41 NM_146966 Olfr1247 Olfactory receptor 1247 0.30 NM_146977 Olfr1255 Olfactory receptor 1255 0.29 NM_146983 Olfr1256 Olfactory receptor 1256 0.36 NM_001005568 Olfr1281 Olfactory receptor 1281 0.40 NM_207254 Olfr1286 Olfactory receptor 1286 0.40 NM_146327 Olfr129 Olfactory receptor 129 0.32 NM_146888 Olfr1297 Olfactory receptor 1297 0.33 NM_146652 Olfr13 Olfactory receptor 13 0.40 NM_146884 Olfr1300-ps1 Olfactory receptor 1300, pseudogene 1 0.30 NM_207150 Olfr1313 Olfactory receptor 1313 0.13 NM_146390 Olfr1323 Olfactory receptor 1323 0.20 NM_146398 Olfr1325 Olfactory receptor 1325 0.37 NM_146831 Olfr133 Olfactory receptor 133 0.28 NM_146915 Olfr1336 Olfactory receptor 1336 0.40 NM_146304 Olfr1340 Olfactory receptor 1340 0.41 NM_146543 Olfr1360 Olfactory receptor 1360 0.36 NM_146533 Olfr1367 Olfactory receptor 1367 0.14 NM_146488 Olfr137 Olfactory receptor 137 0.28 NM_146468 Olfr1391 Olfactory receptor 1391 0.40 NM_146470 Olfr1392 Olfactory receptor 1392 0.35

163 NM_146275 Olfr1402 Olfactory receptor 1402 0.33 NM_146984 Olfr142 Olfactory receptor 142 0.14 NM_146687 Olfr1436 Olfactory receptor 1436 0.20 NM_001011839 Olfr1437 Olfactory receptor 1437 0.22 NM_146704 Olfr1446 Olfactory receptor 1446 0.37 NM_146303 Olfr1449 Olfactory receptor 1449 0.39 NM_001011841 Olfr1465 Olfactory receptor 1465 0.30 NM_146690 Olfr1472 Olfactory receptor 1472 0.38 NM_207575 Olfr1480 Olfactory receptor 1480 0.31 NM_146636 Olfr1487 Olfactory receptor 1487 0.35 NM_146265 Olfr1506 Olfactory receptor 1506 0.37 NM_013728 Olfr154 Olfactory receptor 154 0.22 NM_019474 Olfr156 Olfactory receptor 156 0.30 NM_147000 Olfr173 Olfactory receptor 173 0.33 NM_146322 Olfr187 Olfactory receptor 187 0.15 NM_207550 Olfr199 Olfactory receptor 199 0.29 NM_146446 Olfr215 Olfactory receptor 215 0.30 NM_001001809 Olfr218 Olfactory receptor 218 0.21 NM_146770 Olfr259 Olfactory receptor 259 0.38 NM_146607 Olfr270 Olfactory receptor 270 0.35 NM_146824 Olfr273 Olfactory receptor 273 0.27 NM_146281 Olfr284 Olfactory receptor 284 0.26 NM_001011520 Olfr310 Olfactory receptor 310 0.38 NM_146376 Olfr323 Olfactory receptor 323 0.28 NM_147073 Olfr33 Olfactory receptor 33 0.21 NM_146948 Olfr342 Olfactory receptor 342 0.29 NM_146942 Olfr351 Olfactory receptor 351 0.39 NM_146624 Olfr356 Olfactory receptor 356 0.28 NM_146622 Olfr360 Olfactory receptor 360 0.24 NM_147051 Olfr362 Olfactory receptor 362 0.35 NM_146662 Olfr365 Olfactory receptor 365 0.35 NM_146859 Olfr371 Olfactory receptor 371 0.34 NM_147025 Olfr380 Olfactory receptor 380 0.36 NM_147006 Olfr392 Olfactory receptor 392 0.29 NM_147007 Olfr394 Olfactory receptor 394 0.14 NM_147004 Olfr399 Olfactory receptor 399 0.39 NM_146720 Olfr421 Olfactory receptor 421 0.32 NM_146653 Olfr435 Olfactory receptor 435 0.38 NM_146830 Olfr44 Olfactory receptor 44 0.25 NM_146963 Olfr45 Olfactory receptor 45 0.31 NM_146445 Olfr450 Olfactory receptor 450 0.20 NM_146383 Olfr460 Olfactory receptor 460 0.33 NM_146734 Olfr478 Olfactory receptor 478 0.40 NM_146364 Olfr495 Olfactory receptor 495 0.34 NM_146773 Olfr508 Olfactory receptor 508 0.25 NM_146724 Olfr512 Olfactory receptor 512 0.40 NM_146723 Olfr513 Olfactory receptor 513 0.32 NM_146956 Olfr525 Olfactory receptor 525 0.37 NM_001011776 Olfr527 Olfactory receptor 527 0.21 NM_146960 Olfr53 Olfactory receptor 53 0.40 NM_146840 Olfr545 Olfactory receptor 545 0.37 NM_147088 Olfr569 Olfactory receptor 569 0.34 NM_147115 Olfr578 Olfactory receptor 578 0.23 NM_147053 Olfr582 Olfactory receptor 582 0.35 NM_147054 Olfr584 Olfactory receptor 584 0.20 NM_147087 Olfr585 Olfactory receptor 585 0.36 NM_147111 Olfr586 Olfactory receptor 586 0.24 NM_147052 Olfr589 Olfactory receptor 589 0.32

164 NM_146380 Olfr593 Olfactory receptor 593 0.38 NM_146731 Olfr599 Olfactory receptor 599 0.22 NM_147082 Olfr609 Olfactory receptor 609 0.16 NM_001011865 Olfr624 Olfactory receptor 624 0.22 NM_001025386 Olfr627 Olfactory receptor 627 0.38 NM_147119 Olfr632 Olfactory receptor 632 0.22 NM_147118 Olfr635 Olfactory receptor 635 0.26 NM_147072 Olfr641 Olfactory receptor 641 0.36 NM_147077 Olfr643 Olfactory receptor 643 0.27 NM_147048 Olfr652 Olfactory receptor 652 0.26 NM_147096 Olfr666 Olfactory receptor 666 0.21 NM_001011533 Olfr688 Olfactory receptor 688 0.27 NM_020290 Olfr690 Olfactory receptor 690 0.34 NM_147061 Olfr691 Olfactory receptor 691 0.34 NM_146598 Olfr695 Olfactory receptor 695 0.30 NM_146604 Olfr716 Olfactory receptor 716 0.20 NM_146494 Olfr722 Olfactory receptor 722 0.38 NM_146317 Olfr725 Olfactory receptor 725 0.31 NM_054090 Olfr73 Olfactory receptor 73 0.30 NM_146363 Olfr731 Olfactory receptor 731 0.31 NM_146665 Olfr732 Olfactory receptor 732 0.39 NM_054091 Olfr74 Olfactory receptor 74 0.19 NM_146298 Olfr746 Olfactory receptor 746 0.25 NM_001011837 Olfr748 Olfactory receptor 748 0.19 NM_146266 Olfr772 Olfactory receptor 772 0.34 NM_207008 Olfr773-ps1 Olfactory receptor 773, pseudogene 1 0.37 NM_146284 Olfr780 Olfactory receptor 780 0.40 NM_146551 Olfr788 Olfactory receptor 788 0.40 NM_146933 Olfr790 Olfactory receptor 790 0.41 NM_146556 Olfr798 Olfactory receptor 798 0.30 NM_146927 Olfr799 Olfactory receptor 799 0.41 NM_001011821 Olfr804 Olfactory receptor 804 0.25 NM_207159 Olfr814 Olfactory receptor 814 0.40 NM_146673 Olfr823 Olfactory receptor 823 0.37 NM_147067 Olfr829 Olfactory receptor 829 0.17 NM_146522 Olfr854 Olfactory receptor 854 0.32 NM_146526 Olfr859 Olfactory receptor 859 0.15 NM_001011748 Olfr867 Olfactory receptor 867 0.14 NM_146904 Olfr870 Olfactory receptor 870 0.19 NM_146424 Olfr888 Olfactory receptor 888 0.35 NM_146482 Olfr889 Olfactory receptor 889 0.21 NM_146481 Olfr890 Olfactory receptor 890 0.21 NM_146336 Olfr893 Olfactory receptor 893 0.37 NM_146811 Olfr910 Olfactory receptor 910 0.37 NM_146375 Olfr918 Olfactory receptor 918 0.13 NM_146781 Olfr922 Olfactory receptor 922 0.27 NM_146816 Olfr923 Olfactory receptor 923 0.40 NM_146441 Olfr933 Olfactory receptor 933 0.15 NM_146513 Olfr95 Olfactory receptor 95 0.40 NM_146330 Olfr958 Olfactory receptor 958 0.22 NM_146367 Olfr976 Olfactory receptor 976 0.21 NM_146286 Olfr981 Olfactory receptor 981 0.29 NM_146435 Olfr993 Olfactory receptor 993 0.25 NM_138648 Olr1 Oxidized low density lipoprotein (lectin-like) receptor 1 0.24 NM_010098 Opn3 Opsin (encephalopsin) 0.31 NM_181753 Opn5 Opsin 5 0.22 NM_011012 Oprl1 Opioid receptor-like 1 0.23 NM_001025378 Orc2l Origin recognition complex, subunit 2-like (S. cerevisiae) 0.38

165 NM_138664 ORF28 Open reading frame 28 0.41 NM_145517 Ormdl1 ORM1-like 1 (S. cerevisiae) 0.35 NM_001037932 OTTMUSG00000000997 Predicted gene, OTTMUSG00000000997 0.39 NM_173746 OTTMUSG00000004461 Predicted gene, OTTMUSG00000004461 0.28 NM_001037926 OTTMUSG00000010173 Predicted gene, OTTMUSG00000010173 0.41 NM_177571 OTTMUSG00000010433 Predicted gene, OTTMUSG00000010433 0.36 NM_001039209 OTTMUSG00000010671 Predicted gene, OTTMUSG00000010671 0.35 NM_206867 OTTMUSG00000011275 Predicted gene, OTTMUSG00000011275 0.31 NM_177848 OTTMUSG00000015529 Predicted gene, OTTMUSG00000015529 0.28 NM_001037929 OTTMUSG00000015643 Predicted gene, OTTMUSG00000015643 0.39 NM_130880 Otud7a OTU domain containing 7A 0.15 NM_172435 P2ry10 Purinergic receptor P2Y, G-protein coupled 10 0.26 NM_130881 Pabpc4 Poly A binding protein, cytoplasmic 4 0.39 NM_153129 Pacs1 Phosphofurin acidic cluster sorting protein 1 0.30 NM_008777 Pah Phenylalanine hydroxylase 0.16 NM_026420 Paip2 Polyadenylate-binding protein-interacting protein 2 0.35 NM_177326 Pak2 P21 (CDKN1A)-activated kinase 2 0.41 NM_008778 Pak3 P21 (CDKN1A)-activated kinase 3 0.24 NM_026157 Papd1 PAP associated domain containing 1 0.24 NM_019943 Papolb Poly (A) polymerase beta (testis specific) 0.31 NM_001005767 Parl Presenilin associated, rhomboid-like 0.34 NM_181402 Parp11 Poly (ADP-ribose) polymerase family, member 11 0.32 NM_011037 Pax2 Paired box gene 2 0.35 NM_023209 Pbk PDZ binding kinase 0.40 NM_130448 Pcdh18 Protocadherin 18 0.35 NM_054072 Pcdha11 Protocadherin alpha 11 0.34 NM_001003671 Pcdha11 Protocadherin alpha 11 0.31 NM_053138 Pcdhb13 Protocadherin beta 13 0.38 NM_053128 Pcdhb3 Protocadherin beta 3 0.27 NM_053132 Pcdhb7 Protocadherin beta 7 0.37 NM_033587 Pcdhga12 Protocadherin gamma subfamily A, 12 0.40 NM_033576 Pcdhga12 Protocadherin gamma subfamily A, 12 0.18 NM_029508 Pcgf5 Polycomb group ring finger 5 0.25 NM_008786 Pcmt1 Protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 0.34 NM_008787 Pcnt Pericentrin (kendrin) 0.31 NM_008791 Pcp4 Purkinje cell protein 4 0.18 NM_011053 Pdcd11 Programmed cell death protein 11 0.25 NM_019840 Pde4b Phosphodiesterase 4B, cAMP specific 0.26 NM_146086 Pde6a Phosphodiesterase 6A, cGMP-specific, rod, alpha 0.41 NM_019971 Pdgfc Platelet-derived growth factor, C polypeptide 0.23 NM_011058 Pdgfra Platelet derived growth factor receptor, alpha polypeptide 0.34 NM_023324 Peli1 Pellino 1 0.38 NM_011070 Pfdn2 Prefoldin 2 0.35 NM_025973 Pgc Progastricsin (pepsinogen C) 0.17 NM_207247 Pglyrp3 Peptidoglycan recognition protein 3 0.30 NM_018774 Phc2 Polyhomeotic-like 2 (Drosophila) 0.37 NM_153421 Phc3 Polyhomeotic-like 3 (Drosophila) 0.18 NM_024250 Phf10 PHD finger protein 10 0.33 NM_199299 Phf15 PHD finger protein 15 0.40 NM_172783 Phka2 alpha 2 0.37 NM_026888 Phkg2 Phosphorylase kinase, gamma 2 (testis) 0.35 NM_153412 Phldb2 Pleckstrin homology-like domain, family B, member 2 0.39 NM_019663 Pias1 Protein inhibitor of activated STAT 1 0.41 NM_011081 Piga Phosphatidylinositol glycan anchor biosynthesis, class A 0.38 NM_026234 Pigm Phosphatidylinositol glycan anchor biosynthesis, class M 0.30 NM_207683 Pik3c2g Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide 0.32 NM_029094 Pik3cb Phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.41 NM_027153 Pir Pirin 0.28

166 NM_008848 Pira6 Paired-Ig-like receptor A6 0.37 NM_013630 Pkd1 Polycystic kidney disease 1 homolog 0.40 NM_011099 Pkm2 Pyruvate kinase, muscle 0.31 NM_026361 Pkp4 Plakophilin 4 0.35 NM_177845 Pla2g4e Phospholipase A2, group IVE 0.25 NM_013737 Pla2g7 Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.35 NM_172695 Plaa Phospholipase A2, activating protein 0.22 NM_019538 Plac1 Placental specific protein 1 0.37 NM_001037634 Plac1l Placenta-specific 1-like 0.27 NM_013829 Plcb4 Phospholipase C, beta 4 0.37 NM_207279 Plcxd1 Phosphatidylinositol-specific phospholipase C, X domain containing 1 0.36 Pleckstrin homology domain containing, family A (phosphoinositide binding NM_133942 Plekha1 specific) member 1 0.40 Pleckstrin homology domain containing, family H (with MyTH4 domain) NM_177606 Plekhh2 member 2 0.37 NM_008881 Plxna1 Plexin A1 0.35 NM_029971 Pmch Pro--concentrating hormone 0.39 NM_019938 Pmfbp1 Polyamine modulated factor 1 binding protein 1 0.24 NM_015810 Polg2 Polymerase (DNA directed), gamma 2, accessory subunit 0.39 NM_008849 Pou1f1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) 0.39 NM_198933 Pou2f1 POU domain, class 2, transcription factor 1 0.25 NM_019489 Ppie Peptidylprolyl isomerase E (cyclophilin E) 0.35 NM_177167 Ppm1e Protein phosphatase 1E (PP2C domain containing) 0.35 NM_175523 Ppm1k Protein phosphatase 1K (PP2C domain containing) 0.34 NM_198931 Ppm1m Protein phosphatase 1M 0.34 NM_001033453 Ppm2c Protein phosphatase 2C, magnesium dependent, catalytic subunit 0.19 NM_028292 Ppme1 Protein phosphatase methylesterase 1 0.17 Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha NM_016891 Ppp2r1a isoform 0.33 NM_024209 Ppp6c Protein phosphatase 6, catalytic subunit 0.26 NM_001002842 Pram1 PML-RAR alpha-regulated adaptor molecule 1 0.24 NM_031390 Pramel3 Preferentially expressed antigen in melanoma-like 3 0.25 NM_033573 Prcc Papillary renal cell carcinoma (translocation-associated) 0.36 NM_029947 Prdm8 PR domain containing 8 0.21 NM_029239 Prkcn Protein kinase C, nu 0.22 NM_008865 Prl3b1 Prolactin family 3, subfamily b, member 1 0.25 NM_010088 Prl8a2 Prolactin family 8, subfamily a, member 2 0.32 NM_011169 Prlr Prolactin receptor 0.32 NM_008935 Prom1 Prominin 1 0.13 NM_175198 Prox2 Prospero homeobox 2 0.34 NM_175249 Psapl1 Prosaposin-like 1 0.39 NM_011182 Pscd3 Pleckstrin homology, Sec7 and coiled-coil domains 3 0.15 NM_030263 Psd3 Pleckstrin and Sec7 domain containing 3 0.32 NM_008943 Psen1 Presenilin 1 0.35 NM_011965 Psma1 Proteasome (prosome, macropain) subunit, alpha type 1 0.39 NM_011968 Psma6 Proteasome (prosome, macropain) subunit, alpha type 6 0.33 NM_011185 Psmb1 Proteasome (prosome, macropain) subunit, beta type 1 0.37 NM_027357 Psmd1 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.35 NM_080554 Psmd5 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.36 NM_026545 Psmd8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.31 NM_134013 Psme4 Proteasome (prosome, macropain) activator subunit 4 0.26 NM_025604 Psmg3 RIKEN cDNA 1810042K04 gene 0.35 NM_001039534 Pstk Phosphoseryl-tRNA kinase 0.37 NM_008959 Ptdss1 Phosphatidylserine synthase 1 0.30 NM_020623 Pth Parathyroid hormone 0.31 NM_008974 Ptp4a2 Protein tyrosine phosphatase 4a2 0.27 NM_011204 Ptpn13 Protein tyrosine phosphatase, non-receptor type 13 0.34 NM_011210 Ptprc Protein tyrosine phosphatase, receptor type, C 0.19 NM_008983 Ptprk Protein tyrosine phosphatase, receptor type, K 0.24

167 NM_011217 Ptprr Protein tyrosine phosphatase, receptor type, R 0.34 NM_011218 Ptprs Protein tyrosine phosphatase, receptor type, S 0.38 NM_008987 Ptx3 Pentraxin related gene 0.39 NM_001025561 Pus1 Pseudouridine synthase 1 0.39 NM_029128 Qtrtd1 Queuine tRNA-ribosyltransferase domain containing 1 0.40 NM_181750 R3hdm1 R3H domain 1 (binds single-stranded nucleic acids) 0.27 NM_017382 Rab11a RAB11a, member RAS oncogene family 0.35 NM_016899 Rab25 RAB25, member RAS oncogene family 0.31 NM_027295 Rab28 RAB28, member RAS oncogene family 0.25 NM_198163 Rab35 RAB35, member RAS oncogene family 0.30 NM_178690 Rab3gap1 RAB3 GTPase activating protein subunit 1 0.33 NM_133717 Rab43 RAB43, member RAS oncogene family 0.31 NM_019773 Rab9 RAB9, member RAS oncogene family 0.39 NM_146121 Rabgap1 RAB GTPase activating protein 1 0.27 NM_019983 Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 0.24 NM_009014 Rad51l1 RAD51-like 1 (S. cerevisiae) 0.25 NM_009015 Rad54l RAD54 like (S. cerevisiae) 0.39 NM_175112 Rae1 RAE1 RNA export 1 homolog (S. pombe) 0.40 NM_178631 Ralyl RALY RNA binding protein-like 0.30 NM_145541 Rap1a RAS-related protein-1a 0.37 NM_181406 Rars2 Arginyl-tRNA synthetase 2, mitochondrial (putative) 0.34 NM_015754 Rbbp9 Retinoblastoma binding protein 9 0.20 NM_173376 Rbmx2 RNA binding motif protein, X-linked 2 0.30 NM_019733 Rbpms RNA binding protein gene with multiple splicing 0.39 NM_207649 Rcan2 Regulator of calcineurin 2 0.37 Regulator of chromosome condensation (RCC1) and BTB (POZ) domain NM_134083 Rcbtb2 containing protein 2 0.35 NM_138580 Rdbp RD RNA-binding protein 0.37 NM_009042 Reg1 Regenerating islet-derived 1 0.40 NM_009043 Reg2 Regenerating islet-derived 2 0.35 NM_011260 Reg3g Regenerating islet-derived 3 gamma 0.24 NM_020509 Retnla Resistin like alpha 0.23 NM_023881 Retnlb Resistin like beta 0.39 NM_138954 Rfpl4 Ret finger protein-like 4 0.34 NM_026446 Rgs19 Regulator of G-protein signaling 19 0.39 NM_015812 Rgs6 Regulator of G-protein signaling 6 0.38 NM_011268 Rgs9 Regulator of G-protein signaling 9 0.29 NM_177370 Rhbdd3 Rhomboid domain containing 3 0.31 NM_153514 Rhobtb2 Rho-related BTB domain containing 2 0.21 NM_023275 Rhoj Ras homolog gene family, member J 0.40 NM_028940 Rlbp1l1 Retinaldehyde binding protein 1-like 1 0.26 NM_029145 Rnase10 Ribonuclease, RNase A family, 10 (non-active) 0.38 NM_028810 Rnd3 Rho family GTPase 3 0.30 NM_033604 Rnf111 Ring finger 111 0.18 NM_026301 Rnf125 Ring finger protein 125 0.37 NM_198251 Rnf133 Ring finger protein 133 0.32 NM_001033043 Rnf17 Ring finger protein 17 0.31 NM_025786 Rnf186 Ring finger protein 186 0.22 NM_011277 Rnf2 Ring finger protein 2 0.27 NM_013846 Ror2 Receptor tyrosine kinase-like orphan receptor 2 0.34 NM_013646 Rora RAR-related orphan receptor alpha 0.31 NM_172521 RP23-336F11.32 Nuclear protein in testis 0.31 NM_198619 RP23-406N5.2 Zinc finger-like protein 0.38 NM_029548 Rph3al Rabphilin 3A-like (without C2 domains) 0.40 NM_013762 Rpl3 Ribosomal protein L3 0.39 NM_133982 Rpp25 Ribonuclease P 25 subunit (human) 0.32 NM_025789 Rshl2a Radial spokehead-like 2A 0.22 NM_001007596 Rtn1 Reticulon 1 0.28 NM_172557 Rufy1 RUN and FYVE domain containing 1 0.16

168 NM_009822 Runx1t1 Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.38 NM_019685 Ruvbl1 RuvB-like protein 1 0.41 NM_027100 Rwdd2a RWD domain containing 2A 0.39 NM_011315 Saa3 Serum amyloid A 3 0.24 NM_030692 Sacm1l SAC1 (suppressor of actin 1, homolog)-like (S. cerevisiae) 0.29 NM_001037221 Samd4 Sterile alpha motif domain containing 4 0.38 NM_023380 Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 0.28 NM_009119 Sap18 Sin3-associated polypeptide 18 0.31 NM_009121 Sat1 Spermidine/spermine N1-acetyl transferase 1 0.35 NM_009129 Scg2 Secretogranin II 0.34 NM_009132 Scin Scinderin 0.41 NM_016717 Scly Selenocysteine lyase 0.36 NM_009134 Scn10a Sodium channel, voltage-gated, type X, alpha 0.38 NM_001013390 Scn4b Sodium channel, type IV, beta 0.32 NM_001039137 Scoc Short coiled-coil protein 0.23 NM_027268 Scrn1 Secernin 1 0.36 NM_001033296 Sel1l2 Sel-1 suppressor of lin-12-like 2 (C. elegans) 0.38 NM_011346 Sell Selectin, lymphocyte 0.29 Sema domain, seven thrombospondin repeats (type 1 and type 1-like), NM_013661 Sema5b transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.35 Sema domain, transmembrane domain (TM), and cytoplasmic domain, NM_199238 Sema6d (semaphorin) 6D 0.35 NM_001034870 Serpina3h Serine (or cysteine) peptidase inhibitor, clade A, member 3H 0.27 NM_172852 Serpinb13 Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13 0.26 NM_009126 Serpinb3a Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A 0.27 NM_201376 Serpinb3d Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D 0.31 NM_009257 Serpinb5 Serine (or cysteine) peptidase inhibitor, clade B, member 5 0.32 NM_148942 Serpinb6c Serine (or cysteine) peptidase inhibitor, clade B, member 6c 0.22 NM_026460 Serpini2 Serine (or cysteine) peptidase inhibitor, clade I, member 2 0.38 NM_026989 Sfrs11 Splicing factor, arginine/serine-rich 11 0.37 NM_009160 Sftpd Surfactant associated protein D 0.40 NM_053196 Sfxn2 Sideroflexin 2 0.29 NM_144838 Sgtb Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 0.34 NM_172788 Sh3md4 SH3 multiple domains 4 0.30 NM_198034 Sidt1 SID1 transmembrane family, member 1 0.41 NM_011377 Sim2 Single-minded homolog 2 (Drosophila) 0.32 NM_025656 Sip1 Survivor of motor neuron protein interacting protein 1 0.23 NM_013730 Slamf1 Signaling lymphocytic activation molecule family member 1 0.40 NM_011387 Slc10a1 Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.21 NM_133648 Slc12a6 Solute carrier family 12, member 6 0.29 NM_028247 Slc16a10 Solute carrier family 16 (monocarboxylic acid transporters), member 10 0.40 NM_027921 Slc16a14 Solute carrier family 16 (monocarboxylic acid transporters), member 14 0.35 NM_146136 Slc16a4 Solute carrier family 16 (monocarboxylic acid transporters), member 4 0.35 Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), NM_182959 Slc17a8 member 8 0.36 NM_011393 Slc1a2 Solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.41 NM_011394 Slc20a2 Solute carrier family 20, member 2 0.22 NM_008767 Slc22a18 Solute carrier family 22 (organic cation transporter), member 18 0.34 NM_018824 Slc23a2 Solute carrier family 23 (nucleobase transporters), member 2 0.26 Solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), NM_020520 Slc25a20 member 20 0.40 NM_009204 Slc2a4 Solute carrier family 2 (facilitated glucose transporter), member 4 0.34 NM_019741 Slc2a5 Solute carrier family 2 (facilitated glucose transporter), member 5 0.33 NM_025286 Slc31a2 Solute carrier family 31, member 2 0.29 NM_026404 Slc35a4 Solute carrier family 35, member A4 0.21 NM_178675 Slc35f1 Solute carrier family 35, member F1 0.35 NM_153170 Slc36a2 Solute carrier family 36 (proton/amino acid symporter), member 2 0.37 NM_133891 Slc44a1 Solute carrier family 44, member 1 0.29 NM_172830 Slc4a9 Solute carrier family 4, sodium bicarbonate cotransporter, member 9 0.30 NM_001003915 Slc5a12 Solute carrier family 5 (sodium/glucose cotransporter), member 12 0.31

169 NM_133184 Slc5a4a Solute carrier family 5, member 4a 0.33 NM_020049 Slc6a14 Solute carrier family 6 (neurotransmitter transporter), member 14 0.27 NM_175328 Slc6a15 Solute carrier family 6 (neurotransmitter transporter), member 15 0.38 NM_011731 Slc6a20 Solute carrier family 6 (neurotransmitter transporter), member 20 0.40 NM_016972 Slc7a8 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 0.33 NM_011406 Slc8a1 Solute carrier family 8 (sodium/calcium exchanger), member 1 0.33 NM_008539 Smad1 MAD homolog 1 (Drosophila) 0.32 NM_008541 Smad5 MAD homolog 5 (Drosophila) 0.35 NM_028534 Smap1 Stromal membrane-associated protein 1 0.35 NM_025695 Smc6 Structural maintenance of chromosomes 6 0.33 NM_211355 Smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.32 NM_021491 Smpd3 Sphingomyelin phosphodiesterase 3, neutral 0.27 NM_177776 Smtnl2 Smoothelin-like 2 0.24 NM_011428 Snap25 Synaptosomal-associated protein 25 0.28 NM_172926 Snx14 Sorting nexin 14 0.32 NM_009230 Soat1 O-acyltransferase 1 0.15 NM_011434 Sod1 1, soluble 0.36 NM_011436 Sorl1 Sortilin-related receptor, LDLR class A repeats-containing 0.26 NM_011445 Sox6 SRY-box containing gene 6 0.35 NM_153115 Spag11 Sperm associated antigen 11 0.36 NM_029599 Spag4l Sperm associated antigen 4-like 0.36 NM_030176 Spata2L Spermatogenesis associated 2-like 0.39 NM_026457 Spert Spermatid associated 0.29 NM_178628 Spg3a Spastic paraplegia 3A homolog (human) 0.33 NM_153176 Spg7 Spastic paraplegia 7 homolog (human) 0.41 NM_183284 Spink2 Serine peptidase inhibitor, Kazal type 2 0.30 NM_009260 Spnb2 Spectrin beta 2 0.36 NM_009265 Sprr1b Small proline-rich protein 1B 0.20 NM_011468 Sprr2a Small proline-rich protein 2A 0.19 NM_011471 Sprr2e Small proline-rich protein 2E 0.38 NM_011478 Sprr3 Small proline-rich protein 3 0.19 NM_173070 Sprr4 Small proline-rich protein 4 0.26 NM_011896 Spry1 Sprouty homolog 1 (Drosophila) 0.36 NM_175467 Sptlc3 Serine palmitoyltransferase, long chain base subunit 3 0.39 NM_175318 Spty2d1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.27 NM_080448 Srgap3 SLIT-ROBO Rho GTPase activating protein 3 0.41 NM_011899 Srp54a Signal recognition particle 54a 0.28 NM_026130 Srpr Signal recognition particle receptor ('docking protein') 0.12 NM_138744 Ssx2ip Synovial sarcoma, X breakpoint 2 interacting protein 0.22 NM_011486 Stat3 Signal transducer and activator of transcription 3 0.32 NM_011490 Stau1 Staufen (RNA binding protein) homolog 1 (Drosophila) 0.39 NM_054098 Steap4 STEAP family member 4 0.29 NM_019635 Stk3 Serine/threonine kinase 3 (Ste20, yeast homolog) 0.35 NM_029916 Stk31 Serine threonine kinase 31 0.19 NM_019641 Stmn1 Stathmin 1 0.17 NM_009133 Stmn3 Stathmin-like 3 0.29 NM_175367 Ston2 Stonin 2 0.36 NM_133789 Strn4 Striatin, calmodulin binding protein 4 0.26 NM_011506 Sucla2 Succinate-Coenzyme A ligase, ADP-forming, beta subunit 0.21 NM_146224 Suhw4 Suppressor of hairy wing homolog 4 (Drosophila) 0.31 NM_146177 Suv420h2 Suppressor of variegation 4-20 homolog 2 (Drosophila) 0.34 NM_001003952 Sval3 Seminal vesicle antigen-like 3 0.33 NM_013679 Svs6 Seminal vesicle secretory protein 6 0.39 NM_020264 Svs7 Seminal vesicle secretory protein 7 0.38 NM_011516 Sycp1 Synaptonemal complex protein 1 0.37 NM_011517 Sycp3 Synaptonemal complex protein 3 0.32 NM_011518 Syk Spleen tyrosine kinase 0.19 NM_009304 Syngr2 Synaptogyrin 2 0.38

170 NM_025292 Synj2bp Synaptojanin 2 binding protein 0.39 NM_172804 Syt16 Synaptotagmin XVI 0.39 NM_009308 Syt4 Synaptotagmin IV 0.39 NM_001008429 Taar3 Trace amine-associated receptor 3 0.12 NM_001010831 Taar9 Trace amine-associated receptor 9 0.28 NM_009311 Tac1 Tachykinin 1 0.38 NM_020614 Taf1b TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B 0.39 NM_175770 Taf7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.38 NM_027139 Taf9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.23 NM_001025313 Tapbp TAP binding protein 0.39 NM_199155 Tas2r110 Taste receptor, type 2, member 110 0.40 NM_207025 Tas2r123 Taste receptor, type 2, member 123 0.26 NM_199158 Tas2r134 Taste receptor, type 2, member 134 0.33 NM_001001452 Tas2r143 Taste receptor, type 2, member 143 0.39 NM_175225 Tasp1 Taspase, threonine aspartase 1 0.34 NM_198664 Tbc1d2 TBC1 domain family, member 2 0.41 NM_020601 Tbl1x Transducin (beta)-like 1 X-linked 0.40 NM_030732 Tbl1xr1 Transducin (beta)-like 1X-linked receptor 1 0.41 NM_029467 Tcam1 Testicular cell adhesion molecule 1 0.32 NM_177919 Tceal5 Transcription elongation factor A (SII)-like 5 0.34 NM_031198 Tcfec Transcription factor EC 0.32 NM_027762 Tchhl1 Trichohyalin-like 1 0.39 NM_013774 Tcl1b4 T-cell leukemia/lymphoma 1B, 4 0.25 NM_011562 Tdgf1 Teratocarcinoma-derived growth factor 0.40 NM_207272 Tdpoz4 TD and POZ domain containing 4 0.25 NM_009348 Tectb Tectorin beta 0.23 NM_019643 Tera Teratocarcinoma expressed, serine rich 0.27 NM_009354 Tert Telomerase reverse transcriptase 0.19 NM_009355 Tesp1 Testicular serine protease 1 0.29 NM_019981 Tex101 Testis expressed gene 101 0.19 NM_146074 Tfb1m Transcription factor B1, mitochondrial 0.24 NM_009361 Tfdp1 Transcription factor Dp 1 0.32 NM_020580 Th1l TH1-like homolog (Drosophila) 0.29 NM_026909 Thap7 THAP domain containing 7 0.37 NM_207278 Tigd4 Tigger transposable element derived 4 0.38 NM_178646 Tigd5 Tigger transposable element derived 5 0.31 NM_025372 Tipin Timeless interacting protein 0.39 NM_011597 Tjp2 Tight junction protein 2 0.41 NM_172664 Tlk1 Tousled-like kinase 1 0.33 NM_011904 Tll2 Tolloid-like 2 0.40 NM_027016 Tloc1 Translocation protein 1 0.32 NM_205823 Tlr12 Toll-like receptor 12 0.37 NM_126166 Tlr3 Toll-like receptor 3 0.33 NM_026617 Tmbim4 Transmembrane BAX inhibitor motif containing 4 0.37 NM_019770 Tmed2 Transmembrane emp24 domain trafficking protein 2 0.40 NM_026211 Tmed9 Transmembrane emp24 protein transport domain containing 9 0.41 NM_025480 Tmem128 Transmembrane protein 128 0.39 NM_025889 Tmem134 Transmembrane protein 134 0.40 NM_175408 Tmem139 Transmembrane protein 139 0.37 NM_026685 Tmem174 Transmembrane protein 174 0.34 NM_026516 Tmem178 Transmembrane protein 178 0.28 NM_020588 Tmem183a Transmembrane protein 183A 0.24 NM_175507 Tmem20 Transmembrane protein 20 0.41 NM_027909 Tmem24 Transmembrane protein 24 0.17 NM_145599 Tmem34 Transmembrane protein 34 0.37 NM_028053 Tmem38b Transmembrane protein 38B 0.39 NM_026407 Tmem39a Transmembrane protein 39a 0.40 NM_138751 Tmem47 Transmembrane protein 47 0.41

171 NM_028264 Tmem55a Transmembrane protein 55A 0.37 NM_172583 Tmem63c Transmembrane protein 63c 0.40 NM_021793 Tmem8 Transmembrane protein 8 (five membrane-spanning domains) 0.40 NM_020050 Tmem9b TMEM9 domain family, member B 0.37 NM_016711 Tmod2 Tropomodulin 2 0.27 NM_016963 Tmod3 0.31 NM_009398 Tnfaip6 Tumor necrosis factor alpha induced protein 6 0.36 NM_011609 Tnfrsf1a Tumor necrosis factor receptor superfamily, member 1a 0.35 NM_001001495 Tnip3 TNFAIP3 interacting protein 3 0.30 NM_011618 Tnnt1 Troponin T1, skeletal, slow 0.36 NM_146112 Tnrc15 Trinucleotide repeat containing 15 0.33 NM_023764 Tollip Toll interacting protein 0.35 NM_001025261 Tpd52 Tumor protein D52 0.28 NM_009413 Tpd52l1 Tumor protein D52-like 1 0.38 NM_182839 Tppp Tubulin polymerization promoting protein 0.35 NM_133252 Tram2 Translocating chain-associating membrane protein 2 0.39 NM_021407 Trem3 Triggering receptor expressed on myeloid cells 3 0.15 NM_198601 Trim52 Tripartite motif-containing 52 0.33 NM_025863 Trim59 Tripartite motif-containing 59 0.28 NM_153110 Trim61 Tripartite motif-containing 61 0.38 NM_016984 Trpc4 Transient receptor potential cation channel, subfamily C, member 4 0.38 NM_012035 Trpc7 Transient receptor potential cation channel, subfamily C, member 7 0.31 NM_022017 Trpv4 Transient receptor potential cation channel, subfamily V, member 4 0.40 NM_022887 Tsc1 Tuberous sclerosis 1 0.38 NM_175146 Tsr2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.27 NM_026213 Ttc33 Tetratricopeptide repeat domain 33 0.25 NM_177625 Ttc5 Tetratricopeptide repeat domain 5 0.29 NM_177765 Ttll13 Tubulin tyrosine ligase-like family, member 13 0.27 NM_009451 Tubb4 Tubulin, beta 4 0.23 NM_019756 Tubd1 Tubulin, delta 1 0.33 NM_054040 Tulp4 Tubby like protein 4 0.32 NM_026954 Tusc1 Tumor suppressor candidate 1 0.35 NM_008971 Twf1 Twinfilin, actin-binding protein, homolog 1 (Drosophila) 0.36 NM_153519 Txndc2 Thioredoxin domain containing 2 (spermatozoa) 0.39 NM_001009935 Txnip Thioredoxin interacting protein 0.38 NM_011662 Tyrobp TYRO protein tyrosine kinase binding protein 0.37 NM_031202 Tyrp1 Tyrosinase-related protein 1 0.27 NM_172712 Ube1l2 Ubiquitin-activating enzyme E1-like 2 0.40 NM_025356 Ube2d3 Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.38 NM_023230 Ube2v1 Ubiquitin-conjugating enzyme E2 variant 1 0.37 NM_011908 Ubl3 Ubiquitin-like 3 0.36 NM_024475 Ublcp1 Ubiquitin-like domain containing CTD phosphatase 1 0.40 NM_011673 Ugcg UDP-glucose 0.40 NM_201643 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.41 NM_009470 Umod Uromodulin 0.23 NM_024451 Unc84a Unc-84 homolog A (C. elegans) 0.27 NM_009474 Uox Urate oxidase 0.29 NM_026573 Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) 0.30 NM_013918 Usp25 Ubiquitin specific peptidase 25 0.34 NM_181399 Usp6nl USP6 N-terminal like 0.25 NM_177387 Ust Uronyl-2-sulfotransferase 0.30 NM_028276 Utp14a UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 0.36 NM_011682 Utrn Utrophin 0.37 NM_053221 V1ra6 Vomeronasal 1 receptor, A6 0.29 NM_053222 V1ra7 Vomeronasal 1 receptor, A7 0.36 NM_053231 V1rc1 Vomeronasal 1 receptor, C1 0.27 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 0.30 NM_134174 V1rc19 Vomeronasal 1 receptor, C19 0.31

172 NM_207543 V1rd10 Vomeronasal 1 receptor, D10 0.36 NM_207618 V1rd18 Vomeronasal 1 receptor, D18 0.38 NM_030740 V1rd3 Vomeronasal 1 receptor, D3 0.34 NM_134191 V1re2 Vomeronasal 1 receptor, E2 0.19 NM_134198 V1rf1 Vomeronasal 1 receptor, F1 0.21 NM_134237 V1rh12 Vomeronasal 1 receptor, H12 0.38 NM_134240 V1rh16 Vomeronasal 1 receptor, H16 0.22 NM_145850 V1rh17 Vomeronasal 1 receptor, H17 0.24 NM_145844 V1rh2 Vomeronasal 1 receptor, H2 0.36 NM_134228 V1rl1 Vomeronasal 1 receptor, L1 0.34 NM_020505 Vav3 Vav 3 oncogene 0.31 NM_011702 Vip Vasoactive intestinal polypeptide 0.36 NM_172269 Vps18 Vacuolar protein sorting 18 (yeast) 0.26 NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) 0.29 NM_172120 Vps41 Vacuolar protein sorting 41 (yeast) 0.41 NM_013841 Vps45 Vacuolar protein sorting 45 (yeast) 0.33 NM_145967 Vstm2a V-set and transmembrane domain containing 2A 0.22 NM_172840 Vwa2 A domain containing 2 0.38 NM_011712 Wbp5 WW domain binding protein 5 0.13 NM_027057 Wdfy1 WD repeat and FYVE domain containing 1 0.40 NM_027740 Wdr51b WD repeat domain 51B 0.41 NM_027946 Wdr68 WD repeat domain 68 0.24 NM_028599 Wdr75 WD repeat domain 75 0.36 NM_201370 Wee2 homolog 2 (S. pombe) 0.39 NM_001004185 Whdc1 WAS protein homology region 2 domain containing 1 0.20 NM_009519 Wnt11 Wingless-related MMTV integration site 11 0.37 NM_175394 Wtap Wilms' tumour 1-associating protein 0.32 NM_133784 Wwtr1 WW domain containing transcription regulator 1 0.40 NM_013753 X99384 CDNA sequence X99384 0.32 NM_011726 Xlr3a X-linked lymphocyte-regulated 3A 0.39 NM_031493 Xlr5b X-linked lymphocyte-regulated 5B 0.23 NM_133216 Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.29 NM_177310 Xpnpep3 X-prolyl aminopeptidase (aminopeptidase P) 3, putative 0.39 NM_001035226 Xpo1 Exportin 1, CRM1 homolog (yeast) 0.34 NM_001033209 Xylb Xylulokinase homolog (H. influenzae) 0.17 NM_026570 Yeats4 YEATS domain containing 4 0.15 NM_009535 Yes1 Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 0.40 NM_023784 Yipf7 Yip1 domain family, member 7 0.20 NM_027166 Ypel5 Yippee-like 5 (Drosophila) 0.29 NM_172643 Zbtb41 Zinc finger and BTB domain containing 41 homolog 0.33 NM_134003 Zc3h10 Zinc finger CCCH type containing 10 0.34 NM_001033795 Zcchc16 Zinc finger, CCHC domain containing 16 0.24 NM_175358 Zdhhc15 Zinc finger, DHHC domain containing 15 0.28 NM_025512 Zfand1 Zinc finger, AN1-type domain 1 0.30 NM_022985 Zfand6 Zinc finger, AN1-type domain 6 0.33 NM_198644 Zfat1 ZFAT zinc finger 1 0.25 NM_001039198 Zfhx2 Zinc finger homeobox 2 0.16 NM_011743 Zfp106 Zinc finger protein 106 0.36 NM_177681 Zfp12 Zinc finger protein 12 0.36 NM_145483 Zfp160 Zinc finger protein 160 0.35 NM_009548 Zfp179 Zinc finger protein 179 0.33 NM_019941 Zfp235 Zinc finger protein 235 0.40 NM_001012330 Zfp238 Zinc finger protein 238 0.38 NM_021346 Zfp318 Zinc finger protein 318 0.38 NM_145600 Zfp330 Zinc finger protein 330 0.40 NM_178411 Zfp334 Zinc finger protein 334 0.32 NM_080461 Zfp358 Zinc finger protein 358 0.27 NM_011756 Zfp36 Zinc finger protein 36 0.27

173 NM_026406 Zfp364 Zinc finger protein 364 0.09 NM_178722 Zfp438 Zinc finger protein 438 0.33 NM_009557 Zfp46 Zinc finger protein 46 0.33 NM_172867 Zfp462 Zinc finger protein 462 0.29 NM_025749 Zfp474 Zinc finger protein 474 0.40 NM_001013777 Zfp488 Zinc finger protein 488 0.26 NM_175477 Zfp574 Zinc finger protein 574 0.31 NM_009560 Zfp60 Zinc finger protein 60 0.41 NM_001024726 Zfp607 Zinc finger proten 607 0.38 NM_177226 Zfp629 Zinc finger protein 629 0.37 NM_009564 Zfp64 Zinc finger protein 64 0.40 NM_178761 Zfp672 Zinc finger protein 672 0.24 NM_182996 Zfp692 Zinc finger protein 692 0.33 NM_172863 Zfp697 Zinc finger protein 697 0.16 NM_178384 Zfp74 Zinc finger protein 74 0.24 NM_145484 Zfp758 Zinc finger protein 758 0.31 NM_172392 Zfp759 Zinc finger protein 759 0.23 NM_001007575 Zfp817 Zinc finger protein 817 0.37 NM_029281 Zfp820 Zinc finger protein 820 0.36 NM_011763 Zfp9 Zinc finger protein 9 0.35 NM_011769 Zim1 Zinc finger, imprinted 1 0.39 NM_177086 Zmat4 Zinc finger, matrin type 4 0.36 NM_001005223 Znhit3 Zinc finger, HIT type 3 0.39 NM_177080 0.18 NM_001033373 0.24 NM_175210 0.27 NM_177131 0.24 NM_175390 0.33 NM_025472 0.35 NM_001033265 0.39 NM_178447 0.41 NM_001033798 0.30 NM_001033788 0.33 NM_176929 0.41 NM_207528 0.31 NM_001037921 0.41 NM_177288 0.29 NM_007716 0.26 NM_175384 0.35 NM_198642 0.23 NM_177166 0.39 NM_177819 0.41 NM_001033483 0.34 NM_178853 0.36 NM_175156 0.36 NM_198646 0.38 NM_008040 0.34 NM_177052 0.40 NM_172976 0.30 NM_001002781 0.32 NM_001033635 0.21 NM_212440 0.36 NM_001024723 0.29 NM_001039096 0.19 NM_175157 0.34 NM_001033200 0.35 NM_181570 0.20 NM_177579 0.18

174 NM_177012 0.32 NM_001013775 0.27 NM_172891 0.20 NM_175261 0.38 NM_026294 0.38 NM_130883 0.40 NM_177057 0.33 NM_027028 0.36 NM_181851 0.38 NM_177148 0.31 NM_001037750 0.30 NM_027302 0.25

SUPPLEMENTAL TABLE S12: Genes Demonstrating Altered Phospho-CREB Binding in the Social Defeat and Social Isolation Models (p<0.001)

Accession Number Symbol Name NM_053102 15-Sep Selenoprotein NM_026757 0610010K14Rik RIKEN cDNA 0610010K14 gene NM_026686 0610011F06Rik RIKEN cDNA 0610011F06 gene NM_026714 0610037D15Rik RIKEN cDNA 0610037D15 gene NM_025364 1110005A23Rik RIKEN cDNA 1110005A23 gene NM_025370 1110018J18Rik RIKEN cDNA 1110018J18 gene NM_172401 1110057K04Rik RIKEN cDNA 1110057K04 gene NM_024172 1500019G21Rik RIKEN cDNA 1500019G21 gene NM_029602 1700022C21Rik RIKEN cDNA 1700022C21 gene NM_021437 1700123O20Rik RIKEN cDNA 1700123O20 gene NM_025463 1810009A15Rik RIKEN cDNA 1810009A15 gene NM_025464 1810021J13Rik RIKEN cDNA 1810021J13 gene NM_175153 2010321M09Rik RIKEN cDNA 2010321M09 gene NM_172398 2310005E10Rik RIKEN cDNA 2310005E10 gene NM_175107 2310022A10Rik RIKEN cDNA 2310022A10 gene NM_025865 2310030G06Rik RIKEN cDNA 2310030G06 gene NM_025542 2410001C21Rik RIKEN cDNA 2410001C21 gene NM_153152 2410015M20Rik RIKEN cDNA 2410015M20 gene NM_183088 2410018M08Rik RIKEN cDNA 2410018M08 gene NM_028611 2410091C18Rik RIKEN cDNA 2410091C18 gene NM_028129 2610020H08Rik RIKEN cDNA 2610020H08 gene NM_170592 2610205E22Rik RIKEN cDNA 2610205E22 gene NM_025599 2610528E23Rik RIKEN cDNA 2610528E23 gene NM_026528 2700060E02Rik RIKEN cDNA 2700060E02 gene NM_173382 2810046L04Rik RIKEN cDNA 2810046L04 gene NM_027279 2810422O20Rik RIKEN cDNA 2810422O20 gene NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene NM_178399 3110035E14Rik RIKEN cDNA 3110035E14 gene NM_199145 3110062M04Rik RIKEN cDNA 3110062M04 gene NM_025699 3230401D17Rik RIKEN cDNA 3230401D17 gene NM_172698 4732418C07Rik RIKEN cDNA 4732418C07 gene NM_177711 4932411G14Rik RIKEN cDNA 4932411G14 gene NM_172901 4933405O20Rik RIKEN cDNA 4933405O20 gene NM_177607 4933430I17Rik RIKEN cDNA 4933430I17 gene

175 NM_194335 4933440H19Rik RIKEN cDNA 4933440H19 gene NM_177314 5330439B14Rik RIKEN cDNA 5330439B14 gene NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene NM_175110 5730577I03Rik RIKEN cDNA 5730577I03 gene NM_146091 5730596K20Rik RIKEN cDNA 5730596K20 gene NM_178243 5830403L16Rik RIKEN cDNA 5830403L16 gene NM_177668 A030001H23Rik RIKEN cDNA A030001H23 gene NM_177194 A130023I24Rik RIKEN cDNA A130023I24 gene NM_001033472 A830080D01Rik RIKEN cDNA A830080D01 gene NM_001024512 AA536717 Expressed sequence AA536717 NM_007378 Abca4 ATP-binding cassette, sub-family A (ABC1), member 4 NM_001033163 Abhd9 Abhydrolase domain containing 9 NM_025988 Acbd4 Acyl-Coenzyme A binding domain containing 4 NM_009598 Ace Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 NM_080633 Aco2 Aconitase 2, mitochondrial NM_207668 Acpp Acid phosphatase, prostate NM_053178 Acsbg1 Acyl-CoA synthetase bubblegum family member 1 NM_028121 Adpgk ADP-dependent glucokinase NM_207219 AI314976 Expressed sequence AI314976 NM_001033199 AI747448 Expressed sequence AI747448 Asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2- NM_183142 Alg11 mannosyltransferase) NM_009662 Alox5 Arachidonate 5-lipoxygenase NM_028717 Als2 Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 NM_033603 Amn Amnionless NM_153319 Amot Angiomotin NM_020581 Angptl4 Angiopoietin-like 4 NM_170728 Ank3 Ankyrin 3, epithelial NM_023472 Ankra2 Ankyrin repeat, family A (RFXANK-like), 2 NM_029245 Ankrd53 Ankyrin repeat domain 53 NM_023210 Anp32e Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit NM_027144 Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 NM_001033329 Arhgef9 Cdc42 guanine nucleotide exchange factor (GEF) 9 NM_026577 Arl13b ADP-ribosylation factor-like 13B NM_029847 Arsk Arylsulfatase K NM_133768 Asl Argininosuccinate lyase NM_009791 Aspm Asp (abnormal spindle)-like, microcephaly associated (Drosophila) NM_025651 Aste1 Asteroid homolog 1 (Drosophila) NM_145425 AV249152 Expressed sequence AV249152 NM_016847 Avpr1a Arginine vasopressin receptor 1A NM_145930 AW549877 Expressed sequence AW549877 NM_009735 B2m Beta-2 microglobulin NM_013863 Bag3 Bcl2-associated athanogene 3 NM_027088 Bap1 Brca1 associated protein 1 NM_144885 BC005624 CDNA sequence BC005624 NM_145430 BC017647 CDNA sequence BC017647 NM_177632 BC022623 CDNA sequence BC022623 NM_199149 BC024868 CDNA sequence BC024868

176 NM_173738 BC027344 CDNA sequence BC027344 NM_153557 BC029214 CDNA sequence BC029214 NM_145943 BC031781 CDNA sequence BC031781 NM_153161 BC037034 CDNA sequence BC037034 NM_177878 BC038925 CDNA sequence BC038925 NM_183143 BC048679 CDNA sequence BC048679 NM_183181 BC050777 CDNA sequence BC050777 NM_145635 BC054059 CDNA sequence BC054059 NM_013867 Bcar3 Breast cancer anti-estrogen resistance 3 NM_009739 Bckdk Branched chain ketoacid dehydrogenase kinase NM_007536 Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d NM_026975 Bola1 BolA-like 1 (E. coli) NM_009764 Brca1 Breast cancer 1 NM_144541 Bre Brain and reproductive organ-expressed protein NM_001008705 Bud31 BUD31 homolog (yeast) NM_181323 C130090K23Rik RIKEN cDNA C130090K23 gene NM_175696 C530028O21Rik RIKEN cDNA C530028O21 gene NM_146170 C87436 Expressed sequence C87436 NM_009781 Cacna1c Calcium channel, voltage-dependent, L type, alpha 1C subunit NM_009788 Calb1 Calbindin-28K NM_172633 Cbln2 Cerebellin 2 precursor protein NM_145595 Cbr4 Carbonyl reductase 4 NM_172428 Ccdc134 Coiled-coil domain containing 134 NM_026186 Ccdc49 Coiled-coil domain containing 49 NM_198616 Ccdc85b Coiled-coil domain containing 85B NM_023731 Ccdc86 Coiled-coil domain containing 86 NM_001002787 Ccin Calicin NM_009827 Cckar Cholecystokinin A receptor NM_007627 Cckbr Cholecystokinin B receptor NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 NM_009690 Cd5l CD5 antigen-like NM_007661 Cdc2l1 Cell division cycle 2-like 1 NM_001008420 Cdh12 Cadherin 12 NM_011800 Cdh20 Cadherin 20 NM_026373 Cdk2ap2 CDK2-associated protein 2 NM_028131 Cenpn Centromere protein N NM_021456 Ces1 Carboxylesterase 1 NM_011801 Cfdp1 Craniofacial development protein 1 NM_025351 Chchd6 Coiled-coil-helix-coiled-coil-helix domain containing 6 NM_007691 Chek1 Checkpoint kinase 1 homolog (S. pombe) NM_018818 Chm Choroidermia NM_024190 Chmp1b Chromatin modifying protein 1B NM_029814 Chmp5 Chromatin modifying protein 5 NM_029633 Clasp2 CLIP associating protein 2 NM_153508 Clstn3 Calsyntenin 3 NM_001039551 Cnnm3 Cyclin M3 NM_019817 Copz1 Coatomer protein complex, subunit zeta 1 NM_009941 Cox4i1 Cytochrome c oxidase subunit IV isoform 1 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc

177 NM_030052 Cox7b2 Cytochrome c oxidase subunit VIIb2 NM_009974 Csnk2a2 Casein kinase 2, alpha prime polypeptide NM_145529 Cstf3 Cleavage stimulation factor, 3' pre-RNA, subunit 3 NM_028868 Cxxc1 CXXC finger 1 (PHD domain) NM_001024926 Cyb5d2 Cytochrome b5 domain containing 2 NM_145474 Cyp2d34 Cytochrome P450, family 2, subfamily d, polypeptide 34 NM_016890 Dctn3 Dynactin 3 NM_152806 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 NM_028038 Ddx28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 NM_028074 Ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 NM_026538 Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 NM_153551 Dennd1c DENN/MADD domain containing 1C NM_177914 Dgkk Diacylglycerol kinase kappa NM_015789 Dkkl1 Dickkopf-like 1 NM_177360 Dmrt3 Doublesex and mab-3 related transcription factor 3 NM_198412 Dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 NM_026082 Dock7 Dedicator of cytokinesis 7 NM_026017 Dullard Dullard homolog (Xenopus laevis) NM_028002 Dus4l Dihydrouridine synthase 4-like (S. cerevisiae) NM_001013380 Dync1li2 Dynein, cytoplasmic 1 light intermediate chain 2 NM_029851 Dync2h1 Dynein cytoplasmic 2 heavy chain 1 NM_001039556 E130016E03Rik RIKEN cDNA E130016E03 gene NM_007893 E4f1 E4F transcription factor 1 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene NM_028932 Eaf1 ELL associated factor 1 NM_010100 Edar Ectodysplasin-A receptor NM_172504 EG212225 Predicted gene, EG212225 NM_177764 EG269902 Predicted gene, EG269902 NM_183309 EG330305 Predicted gene, EG330305 NM_001033540 EG330503 Predicted gene, EG330503 NM_001025240 EG384813 Predicted gene, EG384813 NM_001034909 EG547347 Predicted gene, EG547347 NM_001034909 EG547347 Predicted gene, EG547347 NM_001037923 EG624866 Predicted gene, EG624866 NM_023737 Ehhadh Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase NM_010579 Eif6 Eukaryotic translation initiation factor 6 NM_007924 Ell Elongation factor RNA polymerase II NM_001025388 Eno1 Enolase 1, alpha non-neuron NM_007951 Erh Enhancer of rudimentary homolog (Drosophila) NM_007954 Es1 Esterase 1 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide NM_007960 Etv1 Ets variant gene 1 NM_023794 Etv5 Ets variant gene 5 NM_019393 Exosc9 Exosome component 9 NM_010162 Ext1 Exostoses (multiple) 1 NM_010634 Fabp5 Fatty acid binding protein 5, epidermal NM_172422 Fastkd2 FAST kinase domains 2 NM_175127 Fbxo28 F-box protein 28 NM_015791 Fbxo8 F-box protein 8

178 NM_144960 Fcamr Fc receptor, IgA, IgM, high affinity NM_175684 Fchsd1 FCH and double SH3 domains 1 NM_201230 Fgfr1op Fgfr1 oncogene partner NM_010209 Fh1 Fumarate hydratase 1 NM_146018 Flcn Folliculin NM_001040403 Flot2 Flotillin 2 NM_183186 Foxn3 Forkhead box N3 NM_011936 Fto Fat mass and obesity associated NM_172512 Gabpb2 GA repeat binding protein, beta 2 NM_025961 Gatm Glycine amidinotransferase (L-arginine:glycine amidinotransferase) NM_010259 Gbp1 Guanylate nucleotide binding protein 1 NM_008105 Gcnt2 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme NM_019832 Gkap1 G kinase anchoring protein 1 NM_025466 Gkn1 Gastrokine 1 NM_008132 Glrp1 Glutamine repeat protein 1 NM_153601 Gluld1 Glutamate-ammonia ligase (glutamine synthetase) domain containing 1 NM_001033252 Gm732 Gene model 732, (NCBI) NM_001033407 Gm815 Gene model 815, (NCBI) Guanine nucleotide binding protein (G protein), gamma transducing activity NM_010314 Gngt1 polypeptide 1 NM_008146 Golga3 Golgi autoantigen, golgin subfamily a, 3 NM_030084 Gpr108 G protein-coupled receptor 108 NM_133776 Gpr110 G protein-coupled receptor 110 NM_153394 Gpr156 G protein-coupled receptor 156 NM_001031667 Gsk3a Glycogen synthase kinase 3 alpha NM_026764 Gstm4 Glutathione S-transferase, mu 4 NM_010360 Gstm5 Glutathione S-transferase, mu 5 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 NM_181410 Gtf2h3 General transcription factor IIH, polypeptide 3 NM_032544 Gtpbp3 GTP binding protein 3 NM_181424 Gtpbp5 GTP binding protein 5 NM_008191 Guca2b Guanylate cyclase activator 2b (retina) NM_010293 Gykl1 Glycerol kinase-like 1 NM_010381 H2-Ea Histocompatibility 2, class II antigen E alpha NM_008225 Hcls1 Hematopoietic cell specific Lyn substrate 1 NM_024257 Hdhd3 Haloacid dehalogenase-like hydrolase domain containing 3 NM_025798 Hint3 Histidine triad nucleotide binding protein 3 NM_172746 Hirip3 HIRA interacting protein 3 NM_008270 Hoxb9 Homeo box B9 NM_010470 Hp1bp3 Heterochromatin protein 1, binding protein 3 NM_008309 Htr1d 5-hydroxytryptamine (serotonin) receptor 1D NM_026601 Hyi Hydroxypyruvate isomerase homolog (E. coli) NM_008319 Icam5 Intercellular adhesion molecule 5, telencephalin NM_134126 Ift140 Intraflagellar transport 140 homolog (Chlamydomonas) NM_009879 Ift81 Intraflagellar transport 81 homolog (Chlamydomonas) NM_028078 Igsf5 Immunoglobulin superfamily, member 5 Inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex- NM_026079 Ikbkap associated protein NM_008366 Il2 Interleukin 2 NM_016692 Incenp Inner centromere protein

179 NM_133345 Ing4 Inhibitor of growth family, member 4 NM_008380 Inhba Inhibin beta-A NM_010565 Inhbc Inhibin beta-C NM_183144 Inpp5a Inositol polyphosphate-5-phosphatase A NM_178632 Ints7 Integrator complex subunit 7 NM_153414 Ints9 Integrator complex subunit 9 NM_153134 Irgq Immunity-related GTPase family, Q NM_025368 Josd2 Josephin domain containing 2 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 NM_177791 Kctd19 Potassium channel tetramerisation domain containing 19 NM_011317 Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 NM_008526 Klrb1d Killer cell lectin-like receptor subfamily B member 1D NM_133727 Kptn Kaptin NM_010659 Krt31 Keratin 31 NM_027552 Kynu Kynureninase (L-kynurenine hydrolase) NM_010679 Lalba Lactalbumin, alpha NM_010686 Laptm5 Lysosomal-associated protein transmembrane 5 NM_010686 Laptm5 Lysosomal-associated protein transmembrane 5 NM_010688 Lasp1 LIM and SH3 protein 1 NM_025984 Lce1a1 Late cornified envelope 1A1 Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM NM_011095 Lilrb3 domains), member 3 NM_010723 Lmo4 LIM domain only 4 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 NM_022882 Lpin2 Lipin 2 NM_053201 Magee1 Melanoma antigen, family E, 1 NM_022012 Map3k11 Mitogen activated protein kinase kinase kinase 11 NM_026037 Mboat2 Membrane bound O-acyltransferase domain containing 2 NM_008563 Mcm3 Minichromosome maintenance deficient 3 (S. cerevisiae) NM_025297 Mecr Mitochondrial trans-2-enoyl-CoA reductase NM_020048 Med20 Mediator complex subunit 20 NM_026068 Med31 Mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) NM_010796 Mgl1 Macrophage galactose N-acetyl-galactosamine specific lectin 1 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase NM_019944 Mnx1 Motor neuron and pancreas homeobox 1 NM_198162 Morc2a Microrchidia 2A NM_008625 Mrc1 Mannose receptor, C type 1 NM_053162 Mrpl34 Mitochondrial ribosomal protein L34 NM_025595 Mrpl51 Mitochondrial ribosomal protein L51 NM_030116 Mrpl9 Mitochondrial ribosomal protein L9 NM_026422 Mrrf Mitochondrial ribosome recycling factor NM_013601 Msx2 Homeo box, msh-like 2 NM_134092 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein NM_133767 Mtif2 Mitochondrial translational initiation factor 2 NM_028860 Mtmr3 Myotubularin related protein 3 NM_013792 Naglu Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) NM_153126 Nat10 N-acetyltransferase 10 NM_026425 Nat5 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) NM_025348 Ndufa3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 NM_025316 Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5

180 NM_023172 Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 NM_016720 Neu3 Neuraminidase 3 NM_026890 Ngdn Neuroguidin, EIF4E binding protein NM_001039351 Nolc1 Nucleolar and coiled-body phosphoprotein 1 NM_181547 Nostrin Nitric oxide synthase trafficker NM_175263 Notum Notum pectinacetylesterase homolog (Drosophila) NM_146150 Nrd1 Nardilysin, N-arginine dibasic convertase, NRD convertase 1 NM_026746 Nsmce2 Non-SMC element 2 homolog (MMS21, S. cerevisiae) NM_153136 Nudt18 Nudix (nucleoside diphosphate linked moiety X)-type motif 18 NM_172410 Nup93 Nucleoporin 93 NM_146921 Olfr1 Olfactory receptor 1 NM_001011721 Olfr100 Olfactory receptor 100 NM_146573 Olfr1002 Olfactory receptor 1002 NM_146843 Olfr1097 Olfactory receptor 1097 NM_146845 Olfr1098 Olfactory receptor 1098 NM_001011836 Olfr1129 Olfactory receptor 1129 NM_001011517 Olfr1193 Olfactory receptor 1193 NM_146897 Olfr1214 Olfactory receptor 1214 NM_146390 Olfr1323 Olfactory receptor 1323 NM_147000 Olfr173 Olfactory receptor 173 NM_001001809 Olfr218 Olfactory receptor 218 NM_146269 Olfr247 Olfactory receptor 247 NM_146269 Olfr247 Olfactory receptor 247 NM_146415 Olfr291 Olfactory receptor 291 NM_146938 Olfr346 Olfactory receptor 346 NM_146709 Olfr411 Olfactory receptor 411 NM_147101 Olfr549 Olfactory receptor 549 NM_147041 Olfr57 Olfactory receptor 57 NM_147115 Olfr578 Olfactory receptor 578 NM_147119 Olfr632 Olfactory receptor 632 NM_146355 Olfr692 Olfactory receptor 692 NM_146336 Olfr893 Olfactory receptor 893 NM_146375 Olfr918 Olfactory receptor 918 NM_001011518 Olfr94 Olfactory receptor 94 NM_146510 Olfr98 Olfactory receptor 98 NM_207525 Opa3 Optic atrophy 3 (human) NM_025661 Ormdl3 ORM1-like 3 (S. cerevisiae) NM_172555 Papolg Poly(A) polymerase gamma NM_001005767 Parl Presenilin associated, rhomboid-like NM_023115 Pcdh15 Protocadherin 15 NM_033587 Pcdhga12 Protocadherin gamma subfamily A, 12 NM_011053 Pdcd11 Programmed cell death protein 11 NM_172665 Pdk1 Pyruvate dehydrogenase kinase, isoenzyme 1 NM_026441 Pef1 Penta-EF hand domain containing 1 NM_153796 Peo1 Progressive external ophthalmoplegia 1 (human) NM_011070 Pfdn2 Prefoldin 2 NM_153412 Phldb2 Pleckstrin homology-like domain, family B, member 2 NM_029293 Phpt1 Phosphohistidine phosphatase 1 NM_181414 Pik3c3 Phosphoinositide-3-kinase, class 3

181 NM_011098 Pitx2 Paired-like homeodomain transcription factor 2 NM_008861 Pkd2 Polycystic kidney disease 2 NM_011099 Pkm2 Pyruvate kinase, muscle NM_008892 Pola1 Polymerase (DNA directed), alpha 1 NM_011132 Pole Polymerase (DNA directed), epsilon NM_008849 Pou1f1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) NM_008902 Pp11r Placental protein 11 related NM_028292 Ppme1 Protein phosphatase methylesterase 1 NM_021529 Ppp2r3c Protein phosphatase 2, regulatory subunit B'', gamma NM_172574 Pqlc3 PQ loop repeat containing NM_178249 Pramel6 Preferentially expressed antigen in melanoma like 6 NM_008925 Prkcsh Protein kinase C substrate 80K-H NM_011181 Pscd2 Pleckstrin homology, Sec7 and coiled-coil domains 2 NM_011965 Psma1 Proteasome (prosome, macropain) subunit, alpha type 1 NM_011970 Psmb2 Proteasome (prosome, macropain) subunit, beta type 2 NM_080554 Psmd5 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 NM_026545 Psmd8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 NM_198163 Rab35 RAB35, member RAS oncogene family NM_175562 Rab39 RAB39, member RAS oncogene family NM_145510 Rabif RAB interacting factor NM_175112 Rae1 RAE1 RNA export 1 homolog (S. pombe) NM_009067 Ralbp1 RalA binding protein 1 NM_023130 Raly HnRNP-associated with lethal yellow NM_177721 Ranbp6 RAN binding protein 6 NM_028226 Rbm12b RNA binding motif protein 12B NM_009032 Rbm4 RNA binding motif protein 4 NM_173445 Rccd1 RCC1 domain containing 1 NM_011260 Reg3g Regenerating islet-derived 3 gamma NM_009044 Rel Reticuloendotheliosis oncogene NM_181988 Rerg RAS-like, estrogen-regulated, growth-inhibitor NM_011267 Rgs16 Regulator of G-protein signaling 16 NM_177370 Rhbdd3 Rhomboid domain containing 3 NM_008955 Rhox6 Reproductive homeobox 6 NM_027187 Rnaseh2a Ribonuclease H2, large subunit NM_033604 Rnf111 Ring finger 111 NM_024218 Rpl24 Ribosomal protein L24 NM_024212 Rpl4 Ribosomal protein L4 NM_023133 Rps19 Ribosomal protein S19 NM_009093 Rps29 Ribosomal protein S29 NM_009096 Rps6 Ribosomal protein S6 NM_173450 Rpusd2 RNA pseudouridylate synthase domain containing 2 NM_175542 Rttn Rotatin NM_001034060 Rufy4 RUN and FYVE domain containing 4 NM_011315 Saa3 Serum amyloid A 3 NM_007644 Scarb2 Scavenger receptor class B, member 2 NM_009130 Scg3 Secretogranin III NM_153125 Sec16a SEC16 homolog A (S. cerevisiae) NM_001033296 Sel1l2 Sel-1 suppressor of lin-12-like 2 (C. elegans) Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and NM_011976 Sema4g short cytoplasmic domain, (semaphorin) 4G

182 NM_175102 Sf3b5 Splicing factor 3b, subunit 5 NM_009160 Sftpd Surfactant associated protein D NM_172788 Sh3md4 SH3 multiple domains 4 NM_145406 Slc10a3 Solute carrier family 10 (sodium/bile acid cotransporter family), member 3 NM_011394 Slc20a2 Solute carrier family 20, member 2 NM_008767 Slc22a18 Solute carrier family 22 (organic cation transporter), member 18 Solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), NM_013770 Slc25a10 member 10 NM_009579 Slc30a1 Solute carrier family 30 (zinc transporter), member 1 NM_008540 Smad4 MAD homolog 4 (Drosophila) NM_008574 Smcp Sperm mitochondria-associated cysteine-rich protein NM_134034 Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) NM_144918 Smyd5 SET and MYND domain containing 5 NM_013669 Snap91 Synaptosomal-associated protein 91 NM_019727 Snx1 Sorting nexin 1 NM_172926 Snx14 Sorting nexin 14 NM_011436 Sorl1 Sortilin-related receptor, LDLR class A repeats-containing NM_011438 Sox12 SRY-box containing gene 12 NM_011441 Sox17 SRY-box containing gene 17 NM_009238 Sox4 SRY-box containing gene 4 NM_013672 Sp1 Trans-acting transcription factor 1 NM_172561 Spag7 Sperm associated antigen 7 NM_026457 Spert Spermatid associated NM_178628 Spg3a Spastic paraplegia 3A homolog (human) NM_026130 Srpr Signal recognition particle receptor ('docking protein') NM_019641 Stmn1 Stathmin 1 NM_146177 Suv420h2 Suppressor of variegation 4-20 homolog 2 (Drosophila) NM_020614 Taf1b TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B NM_029467 Tcam1 Testicular cell adhesion molecule 1 NM_009348 Tectb Tectorin beta NM_019643 Tera Teratocarcinoma expressed, serine rich NM_019981 Tex101 Testis expressed gene 101 NM_009359 Tex9 Testis expressed gene 9 NM_031199 Tgfa Transforming growth factor alpha NM_177726 Tgm6 Transglutaminase 6 NM_009444 Tgoln1 Trans-golgi network protein NM_199042 Thap1 THAP domain containing, apoptosis associated protein 1 NM_153552 Thoc1 THO complex 1 NM_178646 Tigd5 Tigger transposable element derived 5 NM_019770 Tmed2 Transmembrane emp24 domain trafficking protein 2 NM_025889 Tmem134 Transmembrane protein 134 NM_027909 Tmem24 Transmembrane protein 24 NM_146234 Tmem32 Transmembrane protein 32 NM_025339 Tmem42 Transmembrane protein 42 NM_144794 Tmem63a Transmembrane protein 63a NM_016711 Tmod2 Tropomodulin 2 NM_144812 Tnrc6b Trinucleotide repeat containing 6b NM_009418 Tpp2 Tripeptidyl peptidase II NM_001024206 Trappc1 Trafficking protein particle complex 1 NM_053170 Trim33 Tripartite motif protein 33

183 NM_025863 Trim59 Tripartite motif-containing 59 NM_001013616 Trim6 Tripartite motif protein 6 NM_024168 Tsen34 TRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae) NM_207228 Tsga10 Testis specific 10 NM_175274 Ttyh3 Tweety homolog 3 (Drosophila) NM_172253 Twistnb TWIST neighbor NM_015762 Txnrd1 Thioredoxin reductase 1 NM_031202 Tyrp1 Tyrosinase-related protein 1 NM_028283 Uaca Uveal autoantigen with coiled-coil domains and ankyrin repeats NM_011664 Ubb Ubiquitin B NM_172712 Ube1l2 Ubiquitin-activating enzyme E1-like 2 NM_026573 Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) NM_133992 Usp52 Ubiquitin specific peptidase 52 NM_019729 Usp8 Ubiquitin specific peptidase 8 NM_011702 Vip Vasoactive intestinal polypeptide NM_172269 Vps18 Vacuolar protein sorting 18 (yeast) NM_025783 Vps24 Vacuolar protein sorting 24 (yeast) NM_011710 Wars Tryptophanyl-tRNA synthetase NM_172470 Wdr35 WD repeat domain 35 NM_178739 Wdr40b WD repeat domain 40B NM_176923 Wdr59 WD repeat domain 59 NM_001025375 Wdr61 WD repeat domain 61 NM_027946 Wdr68 WD repeat domain 68 NM_177310 Xpnpep3 X-prolyl aminopeptidase (aminopeptidase P) 3, putative NM_172643 Zbtb41 Zinc finger and BTB domain containing 41 homolog NM_028379 Zdhhc4 Zinc finger, DHHC domain containing 4 NM_178694 Zer1 Zer-1 homolog (C. elegans) NM_133349 Zfand2a Zinc finger, AN1-type domain 2A NM_145547 Zfp189 Zinc finger protein 189 NM_020497 Zfp276 Zinc finger protein (C2H2 type) 276 NM_030743 Zfp313 Zinc finger protein 313 NM_001001186 Zfp456 Zinc finger protein 456 NM_172617 Zfp523 Zinc finger protein 523 NM_175477 Zfp574 Zinc finger protein 574 NM_144523 Zfp622 Zinc finger protein 622 NM_011763 Zfp9 Zinc finger protein 9 NM_011769 Zim1 Zinc finger, imprinted 1 NM_177086 Zmat4 Zinc finger, matrin type 4 NM_001037750 NM_001037921 NM_019427 NM_025472 NM_026297 NM_027681 NM_172976 NM_175354 NM_198646 NM_198646

184 SUPPLEMENTAL TABLE S13: Genes Demonstrating Reversal of Decreased Repressive DimethylK9/K27-H3 Methylation by Imipramine in the Social Defeat Model (p<0.001)

Defeat + Defeat Fold Imipramine Fold Accession Number Symbol Name Change Change NM_026451 1600012H06Rik RIKEN cDNA 1600012H06 gene 0.62 1.31 NM_028528 1700058C13Rik RIKEN cDNA 1700058C13 gene 0.57 1.42 NM_183220 2610203E10Rik RIKEN cDNA 2610203E10 gene 0.56 1.63 NM_026054 2810474O19Rik RIKEN cDNA 2810474O19 gene 0.72 1.30 NM_027510 3830403N18Rik RIKEN cDNA 3830403N18 gene 0.52 1.59 NM_177599 4932415M13Rik RIKEN cDNA 4932415M13 gene 0.70 1.41 NM_025747 4933411K20Rik RIKEN cDNA 4933411K20 gene 0.64 1.34 NM_173400 6230416J20Rik RIKEN cDNA 6230416J20 gene 0.59 1.30 ATP-binding cassette, sub-family G (WHITE), member NM_009593 Abcg1 1 0.56 1.43 NM_145444 Acot5 Acyl-CoA thioesterase 5 0.69 1.37 NM_001033966 Ak2 Adenylate kinase 2 0.72 1.37 NM_134072 Akr1c14 Aldo-keto reductase family 1, member C14 0.66 1.29 NM_001033303 Ampd1 Adenosine monophosphate deaminase 1 (isoform M) 0.65 1.33 NM_026094 Atp8b3 ATPase, Class I, type 8B, member 3 0.72 1.31 NM_001033220 AU021092 Expressed sequence AU021092 0.65 1.34 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene 0.54 1.44 NM_145577 BC023179 CDNA sequence BC023179 0.70 1.37 NM_199150 BC049730 CDNA sequence BC049730 0.62 1.30 Bone gamma-carboxyglutamate protein, related NM_031368 Bglap-rs1 sequence 1 0.58 1.38 NM_009763 Bst1 Bone marrow stromal cell antigen 1 0.70 1.31 NM_178245 Bsx Brain specific homeobox 0.69 1.43 NM_153155 C1ql3 C1q-like 3 0.70 1.34 NM_198017 C430003P19Rik RIKEN cDNA C430003P19 gene 0.71 1.45 NM_177002 C730048C13Rik RIKEN cDNA C730048C13 gene 0.70 1.29 NM_010761 Ccndbp1 Cyclin D-type binding-protein 1 0.70 1.53 NM_017367 Ccni Cyclin I 0.66 1.37 NM_009912 Ccr1 Chemokine (C-C motif) receptor 1 0.63 1.39 NM_009847 Cd2ap CD2-associated protein 0.64 1.31 NM_001033443 Cdkl4 Cyclin-dependent kinase-like 4 0.66 1.36 NM_009892 Chi3l3 Chitinase 3-like 3 0.59 1.41 NM_145126 Chi3l4 Chitinase 3-like 4 0.60 1.41 NM_027562 Clec2g C-type lectin domain family 2, member g 0.71 1.29 NM_053096 Cml2 Camello-like 2 0.41 1.42 NM_026452 Coq9 Coenzyme Q9 homolog (yeast) 0.62 1.42 Cysteine-rich secretory protein LCCL domain NM_031402 Crispld1 containing 1 0.72 1.31 NM_010002 Cyp2c38 Cytochrome P450, family 2, subfamily c, polypeptide 38 0.72 1.32 NM_001011707 Cyp2c66 Cytochrome P450, family 2, subfamily c, polypeptide 66 0.60 1.30 NM_001024719 Cyp2c67 Cytochrome P450, family 2, subfamily c, polypeptide 67 0.64 1.42 NM_173436 Cypt2 Cysteine-rich perinuclear theca 2 0.70 1.31 NM_001004364 Ddef2 Development and differentiation enhancing factor 2 0.66 1.37 NM_013756 Defb3 Defensin beta 3 0.67 1.33 NM_183038 Defb39 Defensin beta 39 0.57 1.32 NM_153108 Defb8 Defensin beta 8 0.70 1.36 NM_183253 Defcr22 Defensin related cryptdin 22 0.72 1.29 NM_001009947 Dock11 Dedicator of cytokinesis 11 0.68 1.38 NM_007887 Dub1 Deubiquitinating enzyme 1 0.71 1.33 NM_029851 Dync2h1 Dynein cytoplasmic 2 heavy chain 1 0.72 1.29 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 0.53 1.46 NM_001001318 EG209380 Predicted gene, EG209380 0.65 1.42 NM_177596 EG210853 Predicted gene, EG210853 0.63 1.32 NM_177890 EG233164 Predicted gene, EG233164 0.67 1.42 NM_001034864 EG236749 Predicted gene, EG236749 0.70 1.35 NM_001034882 EG432879 Predicted gene, EG432879 0.53 1.39 NM_001013816 EG434459 Predicted gene, EG434459 0.55 1.43 NM_007986 Fap Fibroblast activation protein 0.63 1.30

185 NM_008007 Fgf3 Fibroblast growth factor 3 0.68 1.52 NM_008655 Gadd45b Growth arrest and DNA-damage-inducible 45 beta 0.65 1.30 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- NM_173030 Galnt13 acetylgalactosaminyltransferase 13 0.65 1.64 NM_010266 Gda Guanine deaminase 0.62 1.42 NM_001033417 Gm766 Gene model 766, (NCBI) 0.66 1.48 NM_172757 Heatr3 HEAT repeat containing 3 0.72 1.51 NM_010417 Heph Hephaestin 0.61 1.65 NM_008248 Hint1 Histidine triad nucleotide binding protein 1 0.62 1.67 NM_175658 Hist1h2aa Histone cluster 1, H2aa 0.65 1.29 NM_198030 Hsd17b13 Hydroxysteroid (17-beta) dehydrogenase 13 0.59 1.56 NM_153077 Il1f10 Interleukin 1 family, member 10 0.63 1.36 NM_008464 Klra19 Killer cell lectin-like receptor, subfamily A, member 19 0.65 1.38 NM_008463 Klra5 Killer cell lectin-like receptor, subfamily A, member 5 0.63 1.37 NM_001037918 Lipt1 Lipoyltransferase 1 0.70 1.36 NM_177178 Lmbrd2 LMBR1 domain containing 2 0.66 1.36 NM_019390 Lmna Lamin A 0.71 1.37 NM_146191 Lrrk1 Leucine-rich repeat kinase 1 0.72 1.30 NM_008866 Lypla1 Lysophospholipase 1 0.54 1.53 NM_020020 Magea8 Melanoma antigen, family A, 8 0.69 1.31 NM_001003913 Mars Methionine-tRNA synthetase 0.71 1.29 NM_013593 Mb Myoglobin 0.60 1.42 NM_010790 Melk Maternal embryonic leucine zipper kinase 0.69 1.33 NM_205821 Mrgpra6 MAS-related GPR, member A6 0.66 1.30 NM_205810 Mrgprb1 MAS-related GPR, member B1 0.69 1.37 NM_178051 Mterfd2 MTERF domain containing 2 0.68 1.32 NM_008645 Mug1 Murinoglobulin 1 0.72 1.38 NM_001039544 Mup3 Major urinary protein 3 0.50 1.49 NM_008648 Mup4 Major urinary protein 4 0.60 1.53 NM_172896 Nlrp4a NLR family, pyrin domain containing 4A 0.69 1.34 NM_178071 Nme7 Non-metastatic cells 7, protein expressed in 0.68 1.30 NM_198326 Nsfl1c NSFL1 (p97) cofactor (p47) 0.60 1.30 NM_022979 Nup98 Nucleoporin 98 0.72 1.30 NM_147017 Olfr1045 Olfactory receptor 1045 0.71 1.36 NM_147016 Olfr1049 Olfactory receptor 1049 0.73 1.58 NM_147010 Olfr1052 Olfactory receptor 1052 0.70 1.29 NM_001011735 Olfr1066 Olfactory receptor 1066 0.51 1.58 NM_146406 Olfr1076 Olfactory receptor 1076 0.69 1.42 NM_146592 Olfr1086 Olfactory receptor 1086 0.70 1.39 NM_001011771 Olfr1089 Olfactory receptor 1089 0.45 1.49 NM_146767 Olfr1104 Olfactory receptor 1104 0.73 1.35 NM_146849 Olfr1157 Olfactory receptor 1157 0.60 1.41 NM_207566 Olfr1173 Olfactory receptor 1173 0.57 1.29 NM_146791 Olfr1248 Olfactory receptor 1248 0.63 1.30 NM_146887 Olfr1301 Olfactory receptor 1301 0.71 1.32 NM_146797 Olfr1502 Olfactory receptor 1502 0.69 1.39 NM_146485 Olfr183 Olfactory receptor 183 0.73 1.31 NM_146397 Olfr190 Olfactory receptor 190 0.68 1.43 NM_001011791 Olfr193 Olfactory receptor 193 0.72 1.31 NM_147027 Olfr31 Olfactory receptor 31 0.67 1.51 NM_146947 Olfr338 Olfactory receptor 338 0.72 1.35 NM_146656 Olfr444 Olfactory receptor 444 0.65 1.80 NM_001011810 Olfr485 Olfactory receptor 485 0.67 1.39 NM_001011858 Olfr504 Olfactory receptor 504 0.73 1.30 NM_001011865 Olfr624 Olfactory receptor 624 0.67 1.52 NM_020290 Olfr690 Olfactory receptor 690 0.71 1.30 NM_001011797 Olfr782 Olfactory receptor 782 0.64 1.44 NM_001011849 Olfr792 Olfactory receptor 792 0.69 1.35 NM_146524 Olfr855 Olfactory receptor 855 0.72 1.36 NM_146785 Olfr915 Olfactory receptor 915 0.64 1.30 NM_001011812 Olfr951 Olfactory receptor 951 0.67 1.38 NM_147107 Olfr974 Olfactory receptor 974 0.73 1.30 NM_013887 Opn4 Opsin 4 (melanopsin) 0.71 1.45 NM_145517 Ormdl1 ORM1-like 1 (S. cerevisiae) 0.62 1.29

186 NM_011022 Ott Ovary testis transcribed 0.64 1.39 NM_001012323 OTTMUSG00000007485 Predicted gene, OTTMUSG00000007485 0.53 1.34 NM_001037926 OTTMUSG00000010173 Predicted gene, OTTMUSG00000010173 0.70 1.35 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.64 1.33 NM_001039209 OTTMUSG00000010671 Predicted gene, OTTMUSG00000010671 0.72 1.38 NM_001013580 Pard3 Par-3 (partitioning defective 3) homolog (C. elegans) 0.68 1.43 NM_001013369 Pfdn4 Prefoldin 4 0.73 1.39 NM_029404 Phf14 PHD finger protein 14 0.65 1.39 NM_172992 Phtf2 Putative homeodomain transcription factor 2 0.72 1.50 NM_029406 Pih1d1 PIH1 domain containing 1 0.68 1.35 NM_134102 Pla1a Phospholipase A1 member A 0.58 1.34 NM_025928 Pmf1 Polyamine-modulated factor 1 0.69 1.53 NM_029928 Ptprb Protein tyrosine phosphatase, receptor type, B 0.67 1.35 NM_009005 Rab7 RAB7, member RAS oncogene family 0.66 1.47 RNA binding motif protein, Y chromosome, family 1, NM_011253 Rbmy1a1 member A1 0.69 1.37 NM_009048 Reps1 RalBP1 associated Eps domain containing protein 0.72 1.32 NM_020509 Retnla Resistin like alpha 0.55 1.58 NM_181596 Retnlg Resistin like gamma 0.69 1.31 NM_015811 Rgs1 Regulator of G-protein signaling 1 0.73 1.46 NM_025934 Riok2 RIO kinase 2 (yeast) 0.52 1.30 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) NM_172490 Sepsecs tRNA synthase 0.70 1.34 Serine (or cysteine) peptidase inhibitor, clade B, member NM_009254 Serpinb6a 6a 0.57 1.60 NM_198033 Setx Senataxin 0.69 1.45 NM_031179 Sf3b1 Splicing factor 3b, subunit 1 0.73 1.30 NM_012009 Sh2d1b1 SH2 domain protein 1B1 0.56 1.36 Solute carrier family 7 (cationic amino acid transporter, NM_177802 Slc7a15 y+ system), member 15 0.59 1.44 Solute carrier organic anion transporter family, member NM_023718 Slco1a6 1a6 0.60 1.36 NM_021336 Snrpa1 Small nuclear ribonucleoprotein polypeptide A' 0.73 1.30 Spermatogenesis associated glutamate (E)-rich protein NM_025759 Speer4d 4d 0.66 1.39 NM_199319 Ssxb5 Synovial sarcoma, X member B, breakpoint 5 0.73 1.36 NM_207273 Tdpoz5 TD and POZ domain containing 5 0.60 1.31 NM_001039153 Tect1 Tectonic 1 0.72 1.34 NM_013691 Thbs3 Thrombospondin 3 0.63 1.36 NM_001001297 Thnsl1 Threonine synthase-like 1 (bacterial) 0.60 1.30 NM_026281 Tm7sf3 Transmembrane 7 superfamily member 3 0.63 1.59 NM_027495 Tmem144 Transmembrane protein 144 0.62 1.37 Tankyrase, TRF1-interacting ankyrin-related ADP- NM_175091 Tnks ribose polymerase 0.64 1.29 NM_153792 Traf7 Tnf receptor-associated factor 7 0.67 1.39 NM_025701 Trappc5 Trafficking protein particle complex 5 0.69 1.31 NM_011640 Trp53 Transformation related protein 53 0.69 1.30 NM_001038996 Try10 Trypsin 10 0.71 1.29 NM_201641 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.72 1.35 NM_009467 Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.56 1.45 NM_025407 Uqcrc1 Ubiquinol-cytochrome c reductase core protein 1 0.66 1.30 NM_001038589 Usp14 Ubiquitin specific peptidase 14 0.68 1.32 NM_053224 V1ra9 Vomeronasal 1 receptor, A9 0.69 1.33 NM_134167 V1rc12 Vomeronasal 1 receptor, C12 0.64 1.34 NM_053232 V1rc2 Vomeronasal 1 receptor, C2 0.54 1.29 NM_206872 V1rd12 Vomeronasal 1 receptor, D12 0.69 1.37 NM_206868 V1rd13 Vomeronasal 1 receptor, D13 0.66 1.34 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 0.59 1.56 NM_207618 V1rd18 Vomeronasal 1 receptor, D18 0.62 1.34 NM_207546 V1rd20 Vomeronasal 1 receptor, D20 0.53 1.51 NM_134233 V1rg11 Vomeronasal 1 receptor, G11 0.60 1.32 NM_134206 V1rg5 Vomeronasal 1 receptor, G5 0.66 1.42 NM_134238 V1rh13 Vomeronasal 1 receptor, H13 0.71 1.37 NM_134243 V1rh20 Vomeronasal 1 receptor, H20 0.70 1.48

187 NM_134215 V1rh6 Vomeronasal 1 receptor, H6 0.58 1.49 NM_009487 V2r10 Vomeronasal 2, receptor, 10 0.67 1.43 NM_009490 V2r15 Vomeronasal 2, receptor, 15 0.69 1.48 NM_011692 Vbp1 Von Hippel-Lindau binding protein 1 0.69 1.31 NM_175936 Vmn2r81 Vomeronasal 2, receptor 81 0.62 1.49 NM_026044 Wdr85 WD40 repeat domain 85 0.68 1.44 NM_001012704 Wfdc13 WAP four-disulfide core domain 13 0.61 1.39 NM_011725 Xlr X-linked lymphocyte-regulated complex 0.51 1.35 NM_173364 Zfp445 Zinc finger protein 445 0.67 1.57 NM_172792 0.67 1.29 NM_001033788 0.58 1.34 NM_198676 0.71 1.38 NM_001002780 0.57 1.40 NM_001001737 0.69 1.30 NM_001002781 0.50 1.78 NM_001004189 0.69 1.32

SUPPLEMENTAL TABLE S14: Genes Demonstrating Reversal of Increased Repressive DimethylK9/K27-H3 Methylation by Imipramine in the Social Defeat Model (p<0.001)

Defeat Defeat Fold +Imipramine Fold Accession Number Symbol Name Change Change NM_053102 15-Sep Selenoprotein 1.52 0.61 NM_025345 0610037P05Rik RIKEN cDNA 0610037P05 gene 1.51 0.72 NM_026995 0710008K08Rik RIKEN cDNA 0710008K08 gene 1.45 0.72 NM_145955 1110007A13Rik RIKEN cDNA 1110007A13 gene 1.47 0.71 NM_026808 1110028A07Rik RIKEN cDNA 1110028A07 gene 1.41 0.75 NM_198637 1700016K19Rik RIKEN cDNA 1700016K19 gene 1.44 0.75 NM_029335 1700026D08Rik RIKEN cDNA 1700026D08 gene 1.60 0.74 NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene 1.63 0.69 NM_026096 1700054O13Rik RIKEN cDNA 1700054O13 gene 1.65 0.68 NM_183103 1700112C13Rik RIKEN cDNA 1700112C13 gene 1.62 0.63 NM_026627 1700113O17Rik RIKEN cDNA 1700113O17 gene 1.43 0.75 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 1.55 0.71 NM_024249 1810073N04Rik RIKEN cDNA 1810073N04 gene 1.46 0.73 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 1.58 0.70 NM_133829 2210010L05Rik RIKEN cDNA 2210010L05 gene 1.60 0.71 NM_027093 2310003L22Rik RIKEN cDNA 2310003L22 gene 1.54 0.66 NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene 1.68 0.72 NM_027344 2310051M13Rik RIKEN cDNA 2310051M13 gene 1.44 0.76 NM_025542 2410001C21Rik RIKEN cDNA 2410001C21 gene 1.49 0.73 NM_026630 2410116G06Rik RIKEN cDNA 2410116G06 gene 1.44 0.71 NM_027426 2610109H07Rik RIKEN cDNA 2610109H07 gene 1.50 0.68 NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene 1.47 0.72 NM_025849 3110001D03Rik RIKEN cDNA 3110001D03 gene 1.53 0.74 NM_177087 4632412N22Rik RIKEN cDNA 4632412N22 gene 1.55 0.71 NM_175497 4732495G21Rik RIKEN cDNA 4732495G21 gene 1.46 0.73 NM_133797 4833439L19Rik RIKEN cDNA 4833439L19 gene 1.41 0.75 NM_001009544 4921501E09Rik RIKEN cDNA 4921501E09 gene 1.60 0.73 NM_027616 4921528I01Rik RIKEN cDNA 4921528I01 gene 1.52 0.74 NM_134041 4930427A07Rik RIKEN cDNA 4930427A07 gene 1.41 0.71 NM_029141 4930511M11Rik RIKEN cDNA 4930511M11 gene 1.50 0.75 NM_172450 4930539E08Rik RIKEN cDNA 4930539E08 gene 1.45 0.65 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 1.43 0.70 NM_172534 4932411E22Rik RIKEN cDNA 4932411E22 gene 1.42 0.74 NM_025753 4933425O20Rik RIKEN cDNA 4933425O20 gene 1.48 0.75 NM_001033424 5031408O05Rik RIKEN cDNA 5031408O05 gene 1.48 0.69 NM_010667 5430421N21Rik RIKEN cDNA 5430421N21 gene 1.57 0.73 NM_001039586 6230410P16Rik RIKEN cDNA 6230410P16 gene 1.41 0.75 NM_178689 6430537H07Rik RIKEN cDNA 6430537H07 gene 1.50 0.75 NM_001033776 7420416P09Rik RIKEN cDNA 7420416P09 gene 1.54 0.69 NM_030135 8030411F24Rik RIKEN cDNA 8030411F24 gene 1.57 0.73 NM_027840 9130017C17Rik RIKEN cDNA 9130017C17 gene 1.57 0.73

188 NM_177820 9130218O11Rik RIKEN cDNA 9130218O11 gene 1.42 0.71 NM_199017 9230110C19Rik RIKEN cDNA 9230110C19 gene 1.68 0.68 NM_026566 9430023L20Rik RIKEN cDNA 9430023L20 gene 1.43 0.74 NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene 1.94 0.72 NM_183194 9930109F21Rik RIKEN cDNA 9930109F21 gene 1.41 0.71 NM_020591 A030009H04Rik RIKEN cDNA A030009H04 gene 1.66 0.76 NM_153409 A330102K23Rik RIKEN cDNA A330102K23 gene 1.69 0.75 Alpha 1,3-galactosyltransferase 2 NM_001009819 A3galt2 (isoglobotriaosylceramide synthase) 1.63 0.62 NM_177248 A630005I04Rik RIKEN cDNA A630005I04 gene 1.42 0.75 NM_175449 A630077B13Rik RIKEN cDNA A630077B13 gene 1.46 0.75 NM_173759 A730017C20Rik RIKEN cDNA A730017C20 gene 1.44 0.71 NM_175268 A930008G19Rik RIKEN cDNA A930008G19 gene 1.42 0.74 NM_146217 Aars Alanyl-tRNA synthetase 1.42 0.72 ATP-binding cassette, sub-family B (MDR/TAP), NM_008830 Abcb4 member 4 1.53 0.68 ATP-binding cassette, sub-family C (CFTR/MRP), NM_172912 Abcc12 member 12 1.45 0.70 ABO blood group (transferase A, alpha 1-3-N- acetylgalactosaminyltransferase, transferase B, alpha 1- NM_030718 Abo 3-galactosyltransferase) 1.56 0.60 NM_178308 Abpg Androgen binding protein gamma 1.57 0.71 Amiloride-sensitive cation channel 1, neuronal NM_001034013 Accn1 (degenerin) 1.46 0.72 NM_025271 Actl7b Actin-like 7b 1.77 0.70 NM_033268 Actn2 Actinin alpha 2 1.51 0.72 NM_133883 Adprhl2 ADP-ribosylhydrolase like 2 1.65 0.73 NM_013464 Ahr Aryl-hydrocarbon receptor 1.47 0.75 AHA1, activator of heat shock protein ATPase homolog NM_172391 Ahsa2 2 (yeast) 2.15 0.49 NM_177912 AI987692 Expressed sequence AI987692 1.49 0.73 Aldo-keto reductase family 7, member A5 (aflatoxin NM_025337 Akr7a5 aldehyde reductase) 1.44 0.70 NM_009654 Alb Albumin 1.55 0.73 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 1.44 0.68 NM_008537 Amacr Alpha-methylacyl-CoA racemase 1.45 0.69 NM_033603 Amn Amnionless 1.47 0.56 NM_008569 Anapc1 Anaphase promoting complex subunit 1 1.51 0.59 NM_170728 Ank3 Ankyrin 3, epithelial 1.44 0.67 NM_145611 Ankrd25 Ankyrin repeat domain 25 1.48 0.73 NM_029898 Ankrd55 Ankyrin repeat domain 55 1.46 0.66 Anillin, actin binding protein (scraps homolog, NM_028390 Anln Drosophila) 1.47 0.68 NM_172808 Antxrl Anthrax toxin receptor-like 1.57 0.73 Amyloid beta (A4) precursor protein-binding, family B, NM_019456 Apbb1ip member 1 interacting protein 1.61 0.73 NM_030255 Apobec3 Apolipoprotein B editing complex 3 1.60 0.72 NM_133996 Apon Apolipoprotein N 1.49 0.75 NM_175087 Aqp6 Aquaporin 6 1.49 0.73 NM_029270 Arhgap24 Rho GTPase activating protein 24 1.56 0.63 NM_177566 Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 1.46 0.67 NM_024191 Arl2bp ADP-ribosylation factor-like 2 binding protein 1.47 0.75 NM_026034 Armc10 Armadillo repeat containing 10 1.41 0.73 NM_019915 Art2b ADP-ribosyltransferase 2b 1.64 0.74 NM_018731 Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 1.45 0.62 ATP synthase, H+ transporting, mitochondrial F1F0 NM_007507 Atp5k complex, subunit e 1.78 0.63 NM_028844 Aven Apoptosis, caspase activation inhibitor 1.69 0.60 NM_019404 Avpr2 Arginine vasopressin receptor 2 1.44 0.73 Beta-1,3-glucuronyltransferase 2 NM_172124 B3gat2 (glucuronosyltransferase S) 1.61 0.75 NM_144832 BC017643 CDNA sequence BC017643 1.77 0.72 NM_001008549 BC043301 CDNA sequence BC043301 1.68 0.68 NM_010871 Birc1f Baculoviral IAP repeat-containing 1f 1.44 0.73

189 NM_029426 Brsk2 BR serine/threonine kinase 2 1.44 0.72 NM_020558 C1d Nuclear DNA binding protein 1.49 0.75 NM_146016 C230094A16Rik RIKEN cDNA C230094A16 gene 1.43 0.71 NM_016704 C6 Complement component 6 1.50 0.73 NM_146148 C8a Complement component 8, alpha polypeptide 1.45 0.74 NM_178721 Cadm2 Cell adhesion molecule 2 1.49 0.75 NM_007605 Capza3 Capping protein (actin filament) muscle Z-line, alpha 3 1.46 0.65 NM_178396 Car12 Carbonic anyhydrase 12 1.41 0.75 NM_009802 Car6 Carbonic anhydrase 6 1.55 0.75 NM_175362 Card11 Caspase recruitment domain family, member 11 1.65 0.71 NM_009810 Casp3 Caspase 3 1.76 0.59 NM_175369 Ccdc122 Coiled-coil domain containing 122 1.44 0.71 NM_028804 Ccdc3 Coiled-coil domain containing 3 1.43 0.71 NM_175430 Ccdc40 Coiled-coil domain containing 40 1.59 0.68 NM_001012309 Ccdc55 Coiled-coil domain containing 55 1.42 0.74 NM_133744 Ccdc71 Coiled-coil domain containing 71 1.55 0.72 NM_201372 Ccdc84 Coiled-coil domain containing 84 1.52 0.67 NM_207268 Ccdc87 Coiled-coil domain containing 87 1.67 0.72 NM_011330 Ccl11 Small chemokine (C-C motif) ligand 11 1.62 0.71 NM_001013412 Ccl26l Chemokine (C-C motif) ligand 26-like 1.49 0.72 NM_007718 Ccr1l1 Chemokine (C-C motif) receptor 1-like 1 1.48 0.68 NM_172909 Cd163l1 CD163 molecule-like 1 1.48 0.69 NM_007639 Cd1d1 CD1d1 antigen 1.43 0.76 NM_007652 Cd59a CD59a antigen 1.61 0.58 NM_009855 Cd80 CD80 antigen 1.45 0.73 NM_013489 Cd84 CD84 antigen 1.53 0.70 NM_011800 Cdh20 Cadherin 20 1.42 0.61 NM_001033443 Cdkl4 Cyclin-dependent kinase-like 4 1.52 0.75 NM_025496 Cdrt4 CMT1A duplicated region transcript 4 1.76 0.60 Cat eye syndrome chromosome region, candidate 5 NM_144815 Cecr5 homolog (human) 1.42 0.75 NM_177150 Cenpt Centromere protein T 1.62 0.65 NM_145603 Ces2 Carboxylesterase 2 1.57 0.65 NM_025351 Chchd6 Coiled-coil-helix-coiled-coil-helix domain containing 6 1.56 0.70 NM_029814 Chmp5 Chromatin modifying protein 5 1.62 0.69 NM_203491 Chrm2 Cholinergic receptor, muscarinic 2, cardiac 1.55 0.76 NM_016803 Chst3 Carbohydrate (chondroitin 6/keratan) sulfotransferase 3 1.45 0.73 NM_198415 Ckmt2 Creatine kinase, mitochondrial 2 1.44 0.74 NM_009899 Clca1 Chloride channel calcium activated 1 1.44 0.60 NM_019701 Clcnkb Chloride channel Kb 1.47 0.75 NM_001007223 Clec3a C-type lectin domain family 3, member a 1.56 0.70 NM_007713 Clk3 CDC-like kinase 3 1.59 0.70 NM_011802 Clpx Caseinolytic peptidase X (E.coli) 1.42 0.75 CKLF-like MARVEL transmembrane domain NM_028524 Cmtm2b containing 2B 1.69 0.75 CKLF-like MARVEL transmembrane domain NM_153582 Cmtm4 containing 4 1.48 0.74 NM_025771 Cntnap2 Contactin associated protein-like 2 1.50 0.75 NM_001037865 Col28a1 Collagen, type XXVIII, alpha 1 1.48 0.74 NM_029635 Commd9 COMM domain containing 9 1.52 0.74 NM_015827 Copb2 Coatomer protein complex, subunit beta 2 (beta prime) 1.45 0.73 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 1.75 0.64 NM_030052 Cox7b2 Cytochrome c oxidase subunit VIIb2 1.45 0.66 NM_001039049 Cox8c Cytochrome c oxidase, subunit VIIIc 1.71 0.61 NM_027769 Cpne3 Copine III 1.44 0.76 NM_009953 Crhr2 Corticotropin releasing hormone receptor 2 1.81 0.68 NM_153076 Crygn Crystallin, gamma N 1.47 0.72 NM_027874 Csnk1d Casein kinase 1, delta 1.57 0.67 NM_009986 Cutl1 Cut-like 1 (Drosophila) 1.44 0.65 NM_008176 Cxcl1 Chemokine (C-X-C motif) ligand 1 1.49 0.72 NM_009999 Cyp2b10 Cytochrome P450, family 2, subfamily b, polypeptide 10 1.52 0.68 NM_177380 Cyp3a44 Cytochrome P450, family 3, subfamily a, polypeptide 44 1.50 0.73 NM_130882 Cyp4f13 Cytochrome P450, family 4, subfamily f, polypeptide 13 1.43 0.67 NM_008455 Cyp4v3 Cytochrome P450, family 4, subfamily v, polypeptide 3 1.50 0.75

190 NM_177464 D19Ertd386e DNA segment, Chr 19, ERATO Doi 386, expressed 1.47 0.72 NM_007832 Dck Deoxycytidine kinase 1.42 0.72 NM_016890 Dctn3 Dynactin 3 1.56 0.60 NM_016672 Ddc Dopa decarboxylase 1.60 0.71 NM_027156 Ddx51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 1.48 0.72 NM_145157 Defb19 Defensin beta 19 1.52 0.71 NM_018769 Dfna5h Deafness, autosomal dominant 5 homolog (human) 1.46 0.72 NM_138650 Dgkg Diacylglycerol kinase, gamma 1.42 0.68 NM_026191 Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1.53 0.72 NM_001024474 Diras2 DIRAS family, GTP-binding RAS-like 2 1.54 0.65 NM_017470 Dnalc4 Dynein, axonemal, light chain 4 1.57 0.73 NM_007870 Dnase1l3 Deoxyribonuclease 1-like 3 1.46 0.72 NM_019957 Dnase2b Deoxyribonuclease II beta 1.41 0.68 NM_176913 Dpep2 Dipeptidase 2 1.55 0.71 NM_007834 Dscr3 Down syndrome critical region gene 3 1.62 0.63 NM_181682 Dsg1b Desmoglein 1 beta 1.69 0.62 DSN1, MIND kinetochore complex component, NM_025853 Dsn1 homolog (S. cerevisiae) 1.54 0.72 NM_010091 Dvl1 Dishevelled, dsh homolog 1 (Drosophila) 1.46 0.74 NM_007888 Dvl2 Dishevelled 2, dsh homolog (Drosophila) 1.45 0.66 NM_028258 Dzip1l DAZ interacting protein 1-like 1.49 0.67 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 1.70 0.74 NM_139293 Ece2 Endothelin converting enzyme 2 1.47 0.69 NM_007904 Ednrb Endothelin receptor type B 1.47 0.70 NM_177593 EG210155 Predicted gene, EG210155 1.41 0.76 NM_177665 EG229862 Predicted gene, EG229862 1.63 0.68 NM_183320 EG331529 Predicted gene, EG331529 1.49 0.70 NM_198657 EG381438 Predicted gene, EG381438 1.82 0.61 NM_001004162 EG432436 Predicted gene, EG432436 1.47 0.72 NM_001013788 EG432743 Predicted gene, EG432743 1.49 0.75 NM_001004182 EG434008 Predicted gene, EG434008 1.44 0.70 NM_001038697 EG434729 Predicted gene, EG434729 1.49 0.70 NM_001024147 EG545758 Predicted gene, EG545758 1.47 0.72 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) 1.43 0.64 NM_053252 Ehbp1l1 EH domain binding protein 1-like 1 1.61 0.70 Eukaryotic translation initiation factor 4E family NM_001033269 Eif4e1b member 1B 1.42 0.76 NM_010579 Eif6 Eukaryotic translation initiation factor 6 1.59 0.73 Engulfment and cell motility 1, ced-12 homolog (C. NM_080288 Elmo1 elegans) 1.71 0.75 Engulfment and cell motility 2, ced-12 homolog (C. NM_080287 Elmo2 elegans) 1.47 0.71 NM_016885 Emcn Endomucin 1.54 0.75 NM_001030291 Enpp7 Ectonucleotide pyrophosphatase/phosphodiesterase 7 1.50 0.69 NM_145506 Epb4.1l5 Erythrocyte protein band 4.1-like 5 1.59 0.67 NM_007939 Epha8 Eph receptor A8 1.46 0.73 NM_007946 Epx Eosinophil peroxidase 1.45 0.74 NM_007954 Es1 Esterase 1 1.45 0.71 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide 1.50 0.68 NM_016857 Exoc7 Exocyst complex component 7 1.42 0.73 NM_144886 Exosc2 Exosome component 2 1.41 0.71 NM_025923 Fancl Fanconi anemia, complementation group L 1.45 0.70 NM_001033669 Fbxw10 F-box and WD-40 domain protein 10 1.61 0.70 NM_175401 Fbxw17 F-box and WD-40 domain protein 17 1.45 0.73 NM_010190 Fcnb Ficolin B 1.59 0.68 NM_001029984 Fcrlb Fc receptor-like B 1.65 0.66 NM_015759 Fgd3 FYVE, RhoGEF and PH domain containing 3 1.51 0.68 NM_053072 Fgd6 FYVE, RhoGEF and PH domain containing 6 1.57 0.69 NM_010197 Fgf1 Fibroblast growth factor 1 1.64 0.65 NM_019873 Fkbpl FK506 binding protein-like 1.54 0.70 NM_008239 Foxq1 Forkhead box Q1 1.48 0.65 NM_177136 Fryl Furry homolog-like (Drosophila) 1.46 0.72 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 1.41 0.73

191 Gamma-aminobutyric acid (GABA-C) receptor, subunit NM_008075 Gabrr1 rho 1 1.96 0.71 NM_199366 Gal3st2 Galactose-3-O-sulfotransferase 2 1.46 0.75 Glycine amidinotransferase (L-arginine:glycine NM_025961 Gatm amidinotransferase) 1.55 0.69 NM_008376 Gimap1 GTPase, IMAP family member 1 1.53 0.71 NM_018771 Gipc1 GIPC PDZ domain containing family, member 1 1.46 0.67 NM_008123 Gja8 Gap junction membrane channel protein alpha 8 1.47 0.64 NM_008124 Gjb1 Gap junction membrane channel protein beta 1 1.44 0.70 NM_019832 Gkap1 G kinase anchoring protein 1 1.44 0.74 NM_025467 Gkn2 Gastrokine 2 1.45 0.69 NM_198612 Glt8d4 Glycosyltransferase 8 domain containing 4 1.41 0.66 NM_001033473 Gm1157 Gene model 1157, (NCBI) 1.50 0.73 NM_001033403 Gm1968 Gene model 1968, (NCBI) 1.45 0.75 NM_001018031 Gm414 Gene model 414, (NCBI) 2.03 0.63 NM_001033252 Gm732 Gene model 732, (NCBI) 1.58 0.61 NM_008138 Gnai2 Guanine nucleotide binding protein, alpha inhibiting 2 1.46 0.71 NM_025989 Gp2 Glycoprotein 2 (zymogen granule membrane) 1.80 0.62 NM_133776 Gpr110 G protein-coupled receptor 110 1.62 0.63 NM_001033493 Gpr111 G protein-coupled receptor 111 1.61 0.75 NM_001002268 Gpr126 G protein-coupled receptor 126 1.47 0.74 NM_008157 Gpr19 G protein-coupled receptor 19 1.59 0.72 NM_001013832 Gpr31c G protein-coupled receptor 31, D17Leh66c region 1.53 0.67 NM_022320 Gpr35 G protein-coupled receptor 35 1.42 0.75 NM_134438 Gpr37l1 G protein-coupled receptor 37-like 1 1.48 0.73 NM_175493 Gpr68 G protein-coupled receptor 68 1.47 0.70 NM_001033498 Gramd2 GRAM domain containing 2 1.48 0.74 NM_008175 Grn Granulin 1.42 0.72 NM_025768 Grtp1 GH regulated TBC protein 1 1.48 0.75 NM_026764 Gstm4 Glutathione S-transferase, mu 4 1.55 0.75 NM_023630 Gtf2a1l General transcription factor IIA, 1-like 1.44 0.69 NM_145067 Gucy2c Guanylate cyclase 2c 1.48 0.69 NM_008193 Guk1 Guanylate kinase 1 1.55 0.63 NM_013542 Gzmb Granzyme B 1.64 0.65 NM_010381 H2-Ea Histocompatibility 2, class II antigen E alpha 1.49 0.76 NM_177635 H2-M11 Histocompatibility 2, M region locus 11 1.50 0.68 NM_207225 Hdac4 Histone deacetylase 4 1.65 0.66 NM_013547 Hgd Homogentisate 1, 2-dioxygenase 1.65 0.71 NM_018792 Hils1 Histone H1-like protein in spermatids 1 1.46 0.67 NM_010377 Hist1h1t Histone cluster 1, H1t 1.52 0.76 NM_001033245 Hk3 Hexokinase 3 1.51 0.74 NM_175606 Hopx HOP homeobox 1.60 0.75 NM_027661 Hsfy2 Heat shock transcription factor, Y linked 2 1.63 0.70 NM_013558 Hspa1l Heat shock protein 1-like 1.57 0.71 NM_028752 Hvcn1 Hydrogen voltage-gated channel 1 1.63 0.67 NM_031156 Ide Insulin degrading enzyme 1.44 0.67 NM_177197 Idi2 Isopentenyl-diphosphate delta isomerase 2 1.41 0.68 NM_133871 Ifi44 Interferon-induced protein 44 1.47 0.68 NM_053088 Ifitm5 Interferon induced transmembrane protein 5 1.49 0.68 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 1.46 0.76 NM_010546 Ikbkb Inhibitor of kappaB kinase beta 1.75 0.72 NM_010549 Il11ra1 Interleukin 11 receptor, alpha chain 1 1.47 0.64 NM_010551 Il16 Interleukin 16 1.57 0.60 NM_019450 Il1f6 Interleukin 1 family, member 6 1.49 0.73 NM_008362 Il1r1 Interleukin 1 receptor, type I 1.57 0.67 NM_010555 Il1r2 Interleukin 1 receptor, type II 1.55 0.75 NM_008364 Il1rap Interleukin 1 receptor accessory protein 1.48 0.68 NM_145636 Il27 Interleukin 27 1.43 0.76 Integrin-linked kinase-associated serine/threonine NM_023343 Ilkap phosphatase 2C 1.42 0.74 NM_010566 Inpp5d Inositol polyphosphate-5-phosphatase D 1.42 0.73 NM_008386 Ins1 Insulin I 1.58 0.71 NM_176922 Itga11 Integrin, alpha 11 1.59 0.73 NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 1.59 0.69

192 NM_010587 Itsn1 Intersectin 1 (SH3 domain protein 1A) 1.49 0.71 NM_173001 Jmjd1a Jumonji domain containing 1A 1.53 0.66 NM_030887 Jundm2 Jun dimerization protein 2 1.45 0.52 Potassium inwardly rectifying channel, subfamily J, NM_010602 Kcnj11 member 11 1.41 0.72 Potassium inwardly-rectifying channel, subfamily J, NM_001025590 Kcnj6 member 6 1.41 0.74 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 1.52 0.67 NM_010613 Khsrp KH-type splicing regulatory protein 1.48 0.75 NM_010615 Kif11 Kinesin family member 11 1.43 0.73 NM_134471 Kif2c Kinesin family member 2C 1.46 0.73 Killer cell immunoglobulin-like receptor, three domains, NM_177748 Kir3dl2 long cytoplasmic tail, 2 1.48 0.62 NM_178260 Kiss1 KiSS-1 metastasis-suppressor 1.45 0.76 NM_178771 Klhl26 Kelch-like 26 (Drosophila) 1.52 0.60 NM_174865 Klk15 Kallikrein related-peptidase 15 1.79 0.68 NM_010645 Klk1b1 Kallikrein 1-related peptidase b1 1.54 0.66 NM_010644 Klk1b26 Kallikrein 1-related petidase b26 1.45 0.64 Kallikrein related-peptidase 4 (prostase, enamel matrix, NM_019928 Klk4 prostate) 1.94 0.55 NM_010653 Klrc2 Killer cell lectin-like receptor subfamily C, member 2 1.49 0.66 NM_001039124 Kncn Kinocilin 1.65 0.72 NM_008470 Krt16 1.44 0.73 NM_010665 Krt32 Keratin 32 1.70 0.66 NM_027563 Krt34 Keratin 34 1.44 0.75 NM_008475 Krt4 Keratin 4 1.48 0.73 NM_130870 Krtap16-1 Keratin associated protein 16-1 1.62 0.65 NM_010676 Krtap8-2 Keratin associated protein 8-2 1.47 0.66 NM_153558 Lcn13 Lipocalin 13 1.44 0.72 NM_146075 Lemd2 LEM domain containing 2 1.42 0.73 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 1.59 0.73 NM_029796 Lrg1 Leucine-rich alpha-2-glycoprotein 1 1.54 0.66 Low density lipoprotein receptor-related protein 8, NM_053073 Lrp8 apolipoprotein e receptor 1.41 0.74 NM_001033346 Lrrc55 Leucine rich repeat containing 55 1.47 0.71 NM_010745 Ly86 Lymphocyte antigen 86 1.57 0.71 LysM, putative peptidoglycan-binding, domain NM_153121 Lysmd1 containing 1 1.52 0.65 NM_001013802 Macrod2 MACRO domain containing 2 1.55 0.72 NM_020017 Magea3 Melanoma antigen, family A, 3 1.68 0.75 Membrane associated guanylate kinase, WW and PDZ NM_015823 Magi2 domain containing 2 1.46 0.68 NM_001004176 Maml3 Mastermind like 3 (Drosophila) 1.65 0.59 NM_016896 Map3k14 Mitogen-activated protein kinase kinase kinase 14 1.43 0.76 NM_013931 Mapk8ip3 Mitogen-activated protein kinase 8 interacting protein 3 1.54 0.73 Mediator of RNA polymerase II transcription, subunit 11 NM_025397 Med11 homolog (S. cerevisiae) 1.45 0.74 NM_172499 Mfsd9 Major facilitator superfamily domain containing 9 1.41 0.68 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 1.59 0.60 NM_027422 Mier2 Mesoderm induction early response 1, family member 2 1.65 0.72 NM_010798 Mif Macrophage migration inhibitory factor 1.44 0.75 NM_026178 Mmd Monocyte to macrophage differentiation-associated 1.59 0.68 NM_175217 Mmd2 Monocyte to macrophage differentiation-associated 2 1.49 0.75 NM_032007 Mmp1b Matrix metallopeptidase 1b (interstitial collagenase) 1.52 0.69 NM_152944 Mmp21 Matrix metallopeptidase 21 1.50 0.67 NM_010810 Mmp7 Matrix metallopeptidase 7 1.64 0.73 NM_001033450 Mnda Myeloid cell nuclear differentiation antigen 1.53 0.66 NM_010816 Morc1 Microrchidia 1 1.48 0.73 NM_139296 Moxd2 Monooxygenase, DBH-like 2 1.51 0.72 NM_172610 Mpped1 Metallophosphoesterase domain containing 1 1.79 0.65 NM_203490 Mrgprd MAS-related GPR, member D 1.55 0.75 NM_011288 Mrpl23 Mitochondrial ribosomal protein L23 1.57 0.56 NM_183086 Mrps10 Mitochondrial ribosomal protein S10 1.56 0.72 NM_054043 Msi2 Musashi homolog 2 (Drosophila) 1.44 0.74

193 Macrophage stimulating 1 receptor (c-met-related NM_009074 Mst1r tyrosine kinase) 1.68 0.67 NM_008630 Mt2 Metallothionein 2 1.50 0.67 NM_027134 Mtfmt Mitochondrial methionyl-tRNA formyltransferase 1.43 0.68 NM_172958 Mtmr12 Myotubularin related protein 12 1.46 0.70 NM_080457 Muc4 Mucin 4 1.45 0.74 V-myc myelocytomatosis viral oncogene homolog 1, NM_008506 Mycl1 lung carcinoma derived (avian) 1.46 0.75 NM_008669 Naga N-acetyl galactosaminidase, alpha 1.50 0.67 N-acetylglucosamine-1-phosphodiester alpha-N- NM_013796 Nagpa acetylglucosaminidase 1.42 0.75 NM_010874 Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 1.71 0.75 NM_133762 Ncapg2 Non-SMC condensin II complex, subunit G2 1.50 0.65 NM_010887 Ndufs4 NADH dehydrogenase (ubiquinone) Fe-S protein 4 1.57 0.72 NIMA (never in mitosis gene a)-related expressed kinase NM_011848 Nek3 3 1.54 0.66 NM_016718 Ninj2 Ninjurin 2 1.47 0.71 NM_021892 Npvf Neuropeptide VF precursor 1.62 0.67 NM_145354 Nsun2 NOL1/NOP2/Sun domain family 2 1.42 0.73 NM_011955 Nubp1 Nucleotide binding protein 1 1.52 0.72 Nudix (nucleoside diphosphate linked moiety X)-type NM_026497 Nudt12 motif 12 1.73 0.60 Nudix (nucleoside diphosphate linked moiety X)-type NM_025529 Nudt8 motif 8 1.66 0.70 NM_010949 Numb Numb gene homolog (Drosophila) 1.71 0.62 NM_008750 Nxn Nucleoredoxin 1.48 0.62 NM_146762 Olfr1013 Olfactory receptor 1013 1.52 0.52 NM_146586 Olfr1018 Olfactory receptor 1018 1.49 0.70 NM_147017 Olfr1045 Olfactory receptor 1045 1.44 0.74 NM_146778 Olfr1208 Olfactory receptor 1208 1.54 0.71 NM_146985 Olfr1270 Olfactory receptor 1270 1.68 0.72 NM_001011802 Olfr1318 Olfactory receptor 1318 1.42 0.75 NM_207240 Olfr1320 Olfactory receptor 1320 1.64 0.74 NM_001011856 Olfr1331 Olfactory receptor 1331 1.46 0.75 NM_146852 Olfr1339 Olfactory receptor 1339 1.46 0.74 NM_001011790 Olfr1382 Olfactory receptor 1382 1.49 0.75 NM_146472 Olfr1384 Olfactory receptor 1384 1.48 0.69 NM_147065 Olfr1390 Olfactory receptor 1390 1.43 0.73 NM_001011853 Olfr1425 Olfactory receptor 1425 1.80 0.68 NM_019476 Olfr159 Olfactory receptor 159 1.45 0.74 NM_147068 Olfr166 Olfactory receptor 166 1.55 0.74 NM_147001 Olfr172 Olfactory receptor 172 1.52 0.73 NM_146446 Olfr215 Olfactory receptor 215 1.52 0.72 NM_001001809 Olfr218 Olfactory receptor 218 1.47 0.63 NM_146783 Olfr26 Olfactory receptor 26 1.48 0.76 NM_146858 Olfr275 Olfactory receptor 275 1.65 0.73 NM_207153 Olfr325 Olfactory receptor 325 1.74 0.74 NM_001011531 Olfr329 Olfactory receptor 329 1.72 0.72 NM_001011861 Olfr331 Olfactory receptor 331 1.50 0.67 NM_001011863 Olfr406 Olfactory receptor 406 1.67 0.67 NM_146721 Olfr424 Olfactory receptor 424 1.63 0.76 NM_146711 Olfr43 Olfactory receptor 43 1.57 0.73 NM_146716 Olfr432 Olfactory receptor 432 1.95 0.64 NM_146717 Olfr433 Olfactory receptor 433 2.16 0.72 NM_001011528 Olfr456 Olfactory receptor 456 1.48 0.74 NM_146773 Olfr508 Olfactory receptor 508 1.49 0.75 NM_146723 Olfr513 Olfactory receptor 513 1.41 0.75 NM_001011776 Olfr527 Olfactory receptor 527 1.60 0.73 NM_001011815 Olfr533 Olfactory receptor 533 1.65 0.71 NM_146954 Olfr535 Olfactory receptor 535 1.67 0.62 NM_146520 Olfr536 Olfactory receptor 536 1.53 0.72 NM_146962 Olfr541 Olfactory receptor 541 1.53 0.64 NM_147104 Olfr550 Olfactory receptor 550 1.63 0.69 NM_146360 Olfr574 Olfactory receptor 574 1.76 0.63

194 NM_147054 Olfr584 Olfactory receptor 584 1.44 0.71 NM_011002 Olfr59 Olfactory receptor 59 1.57 0.70 NM_146315 Olfr62 Olfactory receptor 62 1.55 0.72 NM_147119 Olfr632 Olfactory receptor 632 1.45 0.67 NM_146820 Olfr655 Olfactory receptor 655 1.81 0.75 NM_020290 Olfr690 Olfactory receptor 690 1.48 0.74 NM_147061 Olfr691 Olfactory receptor 691 1.46 0.73 NM_146355 Olfr692 Olfactory receptor 692 1.48 0.71 NM_146931 Olfr796 Olfactory receptor 796 1.74 0.56 NM_146507 Olfr944 Olfactory receptor 944 1.69 0.73 NM_146828 Olfr975 Olfactory receptor 975 1.74 0.65 NM_201258 Oog3 Oogenesin 3 1.46 0.71 NM_008768 Orm1 Orosomucoid 1 1.48 0.73 NM_177571 OTTMUSG00000010433 Predicted gene, OTTMUSG00000010433 1.46 0.70 NM_001001490 Oxgr1 Oxoglutarate (alpha-ketoglutarate) receptor 1 1.65 0.67 NM_172868 Palm2 Paralemmin 2 1.57 0.68 NM_020606 Parva Parvin, alpha 1.66 0.70 NM_008791 Pcp4 Purkinje cell protein 4 1.46 0.73 NM_008797 Pcx Pyruvate carboxylase 1.44 0.67 NM_016688 Pdcd7 Programmed cell death protein 7 1.71 0.73 NM_153422 Pde5a Phosphodiesterase 5A, cGMP-specific 1.61 0.69 NM_172263 Pde8b Phosphodiesterase 8B 1.60 0.62 NM_008811 Pdha2 Pyruvate dehydrogenase E1 alpha 2 1.56 0.74 NM_008822 Pex7 Peroxisome biogenesis factor 7 1.67 0.68 NM_053191 Pi15 Peptidase inhibitor 15 1.60 0.68 Phosphatidylinositol 3-kinase, C2 domain containing, NM_011084 Pik3c2g gamma polypeptide 1.66 0.65 NM_178149 Pik3ip1 Phosphoinositide-3-kinase interacting protein 1 1.51 0.76 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 1.45 0.75 NM_029686 Pkd1l2 Polycystic kidney disease 1 like 2 1.43 0.70 NM_001029838 Pknox2 Pbx/knotted 1 homeobox 2 1.67 0.68 NM_011107 Pla2g1b Phospholipase A2, group IB, pancreas 1.50 0.67 Pleckstrin homology domain containing, family A NM_133942 Plekha1 (phosphoinositide binding specific) member 1 1.42 0.76 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 1.64 0.71 NM_011128 Pnliprp2 Pancreatic lipase-related protein 2 1.44 0.72 NM_011136 Pou2af1 POU domain, class 2, associating factor 1 1.45 0.71 Protein phosphatase 1G (formerly 2C), magnesium- NM_008014 Ppm1g dependent, gamma isoform 1.59 0.68 NM_138605 Ppp1r3f Protein phosphatase 1, regulatory (inhibitor) subunit 3F 1.47 0.70 NM_027504 Prdm16 PR domain containing 16 1.49 0.75 NM_016703 Preb Prolactin regulatory element binding 1.68 0.58 NM_011073 Prf1 Perforin 1 (pore forming protein) 1.56 0.69 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 1.56 0.64 NM_008865 Prl3b1 Prolactin family 3, subfamily b, member 1 1.44 0.74 NM_011165 Prl4a1 Prolactin family 4, subfamily a, member 1 1.59 0.73 NM_011170 Prnp Prion protein 1.50 0.66 NM_008936 Prop1 Paired like homeodomain factor 1 1.76 0.63 NM_028447 Prrc1 Proline-rich coiled-coil 1 1.57 0.71 NM_009430 Prss2 Protease, serine, 2 1.81 0.69 NM_133351 Prss8 Protease, serine, 8 (prostasin) 1.56 0.69 NM_175249 Psapl1 Prosaposin-like 1 1.57 0.68 NM_028195 Pscd4 Pleckstrin homology, Sec7 and coiled/coil domains 4 1.61 0.72 NM_008965 Ptger4 Prostaglandin E receptor 4 (subtype EP4) 1.45 0.63 Protein tyrosine phosphatase, receptor type, N NM_011215 Ptprn2 polypeptide 2 1.48 0.73 NM_178595 Ptrh1 Peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) 1.56 0.70 NM_029391 Rab4b RAB4B, member RAS oncogene family 1.44 0.73 NM_009028 Rasl2-9 RAS-like, family 2, locus 9 1.44 0.76 NM_015754 Rbbp9 Retinoblastoma binding protein 9 1.71 0.71 NM_138580 Rdbp RD RNA-binding protein 1.56 0.65 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 1.56 0.73 RNA (guanine-9-) methyltransferase domain containing NM_027266 Rg9mtd3 3 1.45 0.75

195 NM_153171 Rgs13 Regulator of G-protein signaling 13 1.55 0.76 NM_021300 Rhox4b Reproductive homeobox 4B 1.75 0.74 NM_201236 Rhox4e Reproductive homeobox 4E 1.51 0.75 NM_026611 Rnaset2b Ribonuclease T2B 1.70 0.73 NM_172521 RP23-336F11.32 Nuclear protein in testis 1.74 0.67 NM_029548 Rph3al Rabphilin 3A-like (without C2 domains) 1.50 0.70 NM_001002239 Rpl17 Ribosomal protein L17 1.56 0.69 NM_009081 Rpl28 Ribosomal protein L28 1.44 0.71 NM_009092 Rps17 Ribosomal protein S17 1.51 0.67 NM_013765 Rps26 Ribosomal protein S26 1.56 0.71 NM_009096 Rps6 Ribosomal protein S6 1.60 0.63 NM_178775 Rps6kc1 Ribosomal protein S6 kinase polypeptide 1 1.57 0.73 Squamous cell carcinoma antigen recognized by T-cells NM_016882 Sart1 1 1.43 0.74 NM_183216 Scd4 Stearoyl-coenzyme A desaturase 4 1.44 0.74 NM_011681 Scgb1a1 Secretoglobin, family 1A, member 1 (uteroglobin) 1.71 0.67 NM_054037 Scgb3a1 Secretoglobin, family 3A, member 1 1.68 0.69 NM_023912 Scyl1 SCY1-like 1 (S. cerevisiae) 1.52 0.74 NM_133704 Sec22a SEC22 vesicle trafficking protein-like A (S. cerevisiae) 1.53 0.69 NM_001029982 Sec23ip Sec23 interacting protein 1.45 0.76 NM_011347 Selp Selectin, platelet 1.62 0.67 Sema domain, transmembrane domain (TM), and NM_199238 Sema6d cytoplasmic domain, (semaphorin) 6D 1.48 0.73 NM_029100 Sepn1 Selenoprotein N, 1 1.47 0.70 Serine (or cysteine) peptidase inhibitor, clade A, NM_009245 Serpina1c member 1c 1.55 0.75 Serine (or cysteine) peptidase inhibitor, clade A, NM_009247 Serpina1e member 1e 1.44 0.72 Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 NM_177920 Serpina7 antiproteinase, antitrypsin), member 7 1.52 0.70 NM_021372 Sertad2 SERTA domain containing 2 1.52 0.66 NM_172788 Sh3md4 SH3 multiple domains 4 1.50 0.73 NM_019658 Shoc2 Soc-2 (suppressor of clear) homolog (C. elegans) 1.49 0.67 Single immunoglobulin and toll-interleukin 1 receptor NM_023059 Sigirr (TIR) domain 1.52 0.68 Sirtuin 2 (silent mating type information regulation 2, NM_022432 Sirt2 homolog) 2 (S. cerevisiae) 1.45 0.73 NM_177016 Slc17a4 Solute carrier family 17 (sodium phosphate), member 4 1.67 0.64 Solute carrier family 1 (glial high affinity glutamate NM_011393 Slc1a2 transporter), member 2 1.67 0.72 Solute carrier family 22 (organic cation transporter), NM_011395 Slc22a3 member 3 1.41 0.73 NM_028048 Slc25a35 Solute carrier family 25, member 35 1.70 0.65 NM_138756 Slc25a36 Solute carrier family 25, member 36 1.58 0.69 NM_177243 Slc26a9 Solute carrier family 26, member 9 1.60 0.64 Solute carrier family 2 (facilitated glucose transporter), NM_178934 Slc2a12 member 12 1.57 0.70 NM_011392 Slc34a1 Solute carrier family 34 (sodium phosphate), member 1 1.77 0.59 Solute carrier family 35 (UDP-N-acetylglucosamine NM_144902 Slc35a3 (UDP-GlcNAc) transporter), member 3 1.71 0.70 NM_134060 Slc35b3 Solute carrier family 35, member B3 1.58 0.74 NM_001039676 Slc39a2 Solute carrier family 39 (zinc transporter), member 2 1.42 0.69 NM_001037493 Slc41a3 Solute carrier family 41, member 3 1.46 0.70 NM_011403 Slc4a1 Solute carrier family 4 (anion exchanger), member 1 1.41 0.69 Solute carrier family 6 (neurotransmitter transporter, L- NM_201353 Slc6a7 proline), member 7 1.67 0.63 Solute carrier organic anion transporter family, member NM_033314 Slco2a1 2a1 1.43 0.66 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing NM_007958 Smarcad1 DEAD/H box 1` 1.44 0.75 NM_211355 Smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 1.43 0.71 NM_007706 Socs2 Suppressor of cytokine signaling 2 1.41 0.71 NM_011366 Sorbs3 Sorbin and SH3 domain containing 3 1.42 0.75

196 NM_001007463 Spag8 Sperm associated antigen 8 1.50 0.68 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 1.62 0.70 NM_183284 Spink2 Serine peptidase inhibitor, Kazal type 2 1.55 0.62 NM_011468 Sprr2a Small proline-rich protein 2A 1.70 0.72 NM_020611 Srd5a2l Steroid 5 alpha-reductase 2-like 1.52 0.71 NM_009283 Stat1 Signal transducer and activator of transcription 1 1.56 0.67 Stress 70 protein chaperone, microsome-associated, NM_030201 Stch human homolog 1.76 0.73 NM_021302 Stk32c Serine/threonine kinase 32C 1.64 0.66 NM_172734 Stk38l Serine/threonine kinase 38 like 1.48 0.69 NM_007941 Stx2 Syntaxin 2 1.57 0.76 NM_026474 Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 1.72 0.60 NM_144871 Suv420h1 Suppressor of variegation 4-20 homolog 1 (Drosophila) 1.49 0.65 NM_145133 T2bp Traf2 binding protein 1.41 0.75 NM_033074 Tars Threonyl-tRNA synthetase 1.45 0.71 NM_207021 Tas2r117 Taste receptor, type 2, member 117 2.38 0.42 NM_199159 Tas2r135 Taste receptor, type 2, member 135 1.56 0.67 NM_013773 Tcl1b1 T-cell leukemia/lymphoma 1B, 1 1.49 0.71 NM_009341 Tcp10c T-complex protein 10c 1.46 0.70 NM_009347 Tecta Tectorin alpha 1.41 0.75 NM_009375 Tg Thyroglobulin 1.52 0.65 NM_177726 Tgm6 Transglutaminase 6 1.73 0.66 NM_028597 Thoc3 THO complex 3 1.61 0.71 NM_146153 Thrap3 Thyroid hormone receptor associated protein 3 1.44 0.72 NM_172476 Tmc7 Transmembrane channel-like gene family 7 1.47 0.66 Transmembrane emp24 protein transport domain NM_025458 Tmed6 containing 6 1.66 0.59 NM_026433 Tmem100 Transmembrane protein 100 1.44 0.65 NM_177735 Tmem130 Transmembrane protein 130 1.52 0.66 NM_018872 Tmem131 Transmembrane protein 131 1.44 0.75 NM_153589 Tmem16b Transmembrane protein 16B 1.48 0.74 NM_172049 Tmem18 Transmembrane protein 18 1.45 0.72 NM_172608 Tmem184b Transmembrane protein 184b 1.43 0.72 NM_027865 Tmem25 Transmembrane protein 25 1.48 0.70 NM_144805 Tmem40 Transmembrane protein 40 1.68 0.71 NM_025693 Tmem41a Transmembrane protein 41a 1.59 0.64 NM_133706 Tmem97 Transmembrane protein 97 1.53 0.70 NM_013749 Tnfrsf12a Tumor necrosis factor receptor superfamily, member 12a 1.54 0.73 Tumor necrosis factor receptor superfamily, member 14 NM_178931 Tnfrsf14 (herpesvirus entry mediator) 1.51 0.67 NM_139064 Tnip2 TNFAIP3 interacting protein 2 1.49 0.75 NM_031880 Tnk1 Tyrosine kinase, non-receptor, 1 1.55 0.71 NM_009407 Tnp1 Transition protein 1 1.52 0.74 NM_031176 Tnxb Tenascin XB 1.55 0.68 NM_023764 Tollip Toll interacting protein 1.48 0.74 NM_001024206 Trappc1 Trafficking protein particle complex 1 1.44 0.64 NM_001025599 Trim26 Tripartite motif protein 26 1.48 0.68 NM_053170 Trim33 Tripartite motif protein 33 1.41 0.66 Transient receptor potential cation channel, subfamily NM_134252 Trpm8 M, member 8 1.43 0.73 TRNA splicing endonuclease 2 homolog (SEN2, S. NM_199033 Tsen2 cerevisiae) 1.50 0.64 NM_019634 Tspan7 Tetraspanin 7 1.63 0.73 NM_175646 Txnl4b Thioredoxin-like 4B 1.72 0.55 NM_177823 Ubash3a Ubiquitin associated and SH3 domain containing, A 1.65 0.69 Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, NM_025985 Ube2g1 C. elegans) 1.50 0.73 NM_198623 Ubqln3 Ubiquilin 3 1.78 0.75 NM_198624 Ubqlnl Ubiquilin-like 1.58 0.70 Ubiquitin carboxyl-terminal esterase L3 (ubiquitin NM_016723 Uchl3 thiolesterase) 1.45 0.74 NM_145079 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 1.52 0.73 NM_009472 Unc5c Unc-5 homolog C (C. elegans) 1.45 0.72 NM_133857 Usp53 Ubiquitin specific peptidase 53 1.47 0.74

197 NM_134166 V1rc11 Vomeronasal 1 receptor, C11 1.47 0.73 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 1.46 0.74 NM_134183 V1rc28 Vomeronasal 1 receptor, C28 1.50 0.63 NM_030739 V1rd4 Vomeronasal 1 receptor, D4 1.47 0.70 NM_134209 V1rg8 Vomeronasal 1 receptor, G8 1.52 0.71 NM_009502 Vcl Vinculin 1.63 0.69 NM_030559 Vps16 Vacuolar protein sorting 16 (yeast) 1.72 0.51 NM_019780 Vps29 Vacuolar protein sorting 29 (S. pombe) 1.55 0.59 NM_011709 Wap Whey acidic protein 1.61 0.75 NM_172864 Wdr63 WD repeat domain 63 1.45 0.68 NM_138685 Wfdc15b WAP four-disulfide core domain 15B 1.45 0.74 X-ray repair complementing defective repair in Chinese NM_009532 Xrcc1 hamster cells 1 1.56 0.74 NM_026570 Yeats4 YEATS domain containing 4 1.51 0.74 NM_145550 Yipf1 Yip1 domain family, member 1 1.46 0.74 NM_027476 Zdhhc24 Zinc finger, DHHC domain containing 24 1.56 0.70 NM_018791 Zfp108 Zinc finger protein 108 1.47 0.66 NM_145483 Zfp160 Zinc finger protein 160 1.42 0.74 NM_148924 Zfp263 Zinc finger protein 263 1.44 0.74 NM_183149 Zfp598 Zinc finger protein 598 1.42 0.71 NM_027264 Zfp715 Zinc finger protein 715 1.45 0.72 NM_028913 Zfp819 Zinc finger protein 819 1.56 0.69 NM_001001130 Zfp85-rs1 Zinc finger protein 85, related sequence 1 1.66 0.72 NM_027061 Zpbp2 Zona pellucida binding protein 2 1.59 0.64 NM_030260 Zxdc ZXD family zinc finger C 1.60 0.75 NM_001033195 1.92 0.73 NM_001024470 1.78 0.69 NM_001025564 1.44 0.76 NM_001014396 1.61 0.71 NM_001013752 1.59 0.71 NM_026461 1.53 0.73 NM_026230 1.54 0.70 NM_133695 1.43 0.70 NM_183215 1.49 0.74 NM_177202 1.56 0.71 NM_028045 1.46 0.69 NM_001002794 1.55 0.75 NM_001024724 1.42 0.72 NM_176992 1.53 0.74 NM_001033814 1.50 0.74 NM_146163 1.47 0.68 NM_011853 1.41 0.68 NM_183120 1.43 0.76 NM_001001987 1.45 0.73 NM_172483 1.52 0.75 NM_172740 1.44 0.74 NM_016664 1.55 0.71 NM_172418 1.47 0.71 NM_001013781 1.68 0.68 NM_177895 1.48 0.65 NM_001002772 1.74 0.66 NM_001037750 1.57 0.67

SUPPLEMENTAL TABLE S15: Genes Demonstrating Reversal of Decreased Phospho-CREB Binding by Imipramine in the Social Defeat Model (p<0.001)

Defeat + Defeat Fold Imipramine Fold Accession Number Symbol Name Change Change NM_053102 15-Sep Selenoprotein 0.42 2.00 NM_001013414 0610025P10Rik RIKEN cDNA 0610025P10 gene 0.33 2.35 NM_026753 1110019N10Rik RIKEN cDNA 1110019N10 gene 0.34 2.25 NM_024172 1500019G21Rik RIKEN cDNA 1500019G21 gene 0.30 3.18

198 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 0.42 2.17 NM_025591 2010309E21Rik RIKEN cDNA 2010309E21 gene 0.42 2.22 NM_027977 2310001A20Rik RIKEN cDNA 2310001A20 gene 0.34 6.57 NM_197991 2310044H10Rik RIKEN cDNA 2310044H10 gene 0.43 2.41 NM_025542 2410001C21Rik RIKEN cDNA 2410001C21 gene 0.34 3.16 NM_028611 2410091C18Rik RIKEN cDNA 2410091C18 gene 0.40 2.29 NM_026511 2810002N01Rik RIKEN cDNA 2810002N01 gene 0.41 2.44 NM_027279 2810422O20Rik RIKEN cDNA 2810422O20 gene 0.30 2.06 NM_028377 2900006K08Rik RIKEN cDNA 2900006K08 gene 0.36 2.32 NM_172698 4732418C07Rik RIKEN cDNA 4732418C07 gene 0.39 2.03 NM_207527 4930504O13Rik RIKEN cDNA 4930504O13 gene 0.39 2.58 NM_198607 4930572J05Rik RIKEN cDNA 4930572J05 gene 0.41 2.21 NM_177230 4932413O14Rik RIKEN cDNA 4932413O14 gene 0.38 2.23 NM_194335 4933440H19Rik RIKEN cDNA 4933440H19 gene 0.40 2.57 NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene 0.28 3.51 NM_178243 5830403L16Rik RIKEN cDNA 5830403L16 gene 0.36 4.63 NM_029960 9230104L09Rik RIKEN cDNA 9230104L09 gene 0.35 2.74 NM_212473 A930008G19Rik RIKEN cDNA A930008G19 gene 0.24 2.11 ATP-binding cassette, sub-family A (ABC1), member NM_177213 Abca15 15 0.39 3.10 NM_013854 Abcf1 ATP-binding cassette, sub-family F (GCN20), member 1 0.38 2.88 NM_025988 Acbd4 Acyl-Coenzyme A binding domain containing 4 0.27 2.71 NM_025271 Actl7b Actin-like 7b 0.43 2.60 NM_178926 AI662250 Expressed sequence AI662250 0.32 2.23 NM_172532 Aldh5a1 Aldhehyde dehydrogenase family 5, subfamily A1 0.37 2.43 NM_198027 Alkbh6 AlkB, alkylation repair homolog 6 (E. coli) 0.18 2.42 NM_033603 Amn Amnionless 0.43 2.18 NM_026904 Anapc10 Anaphase promoting complex subunit 10 0.38 2.31 NM_170728 Ank3 Ankyrin 3, epithelial 0.40 2.01 NM_023472 Ankra2 Ankyrin repeat, family A (RFXANK-like), 2 0.44 2.02 NM_027480 Ankrd24 Ankyrin repeat domain 24 0.29 2.30 Acidic (leucine-rich) nuclear phosphoprotein 32 family, NM_023210 Anp32e member E 0.43 2.80 NM_178408 Arrdc1 Arrestin domain containing 1 0.38 2.86 NM_029847 Arsk Arylsulfatase K 0.31 2.74 NM_007493 Asgr2 Asialoglycoprotein receptor 2 0.35 2.30 NM_177236 Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.28 2.24 NM_001033201 AU014645 Expressed sequence AU014645 0.42 2.08 NM_145425 AV249152 Expressed sequence AV249152 0.35 2.01 NM_177235 B230209C24Rik RIKEN cDNA B230209C24 gene 0.31 2.03 Beta-1,3-glucuronyltransferase 2 NM_172124 B3gat2 (glucuronosyltransferase S) 0.31 2.19 NM_027088 Bap1 Brca1 associated protein 1 0.42 2.17 NM_177632 BC022623 CDNA sequence BC022623 0.45 2.86 NM_153557 BC029214 CDNA sequence BC029214 0.44 2.48 NM_001001181 BC031181 CDNA sequence BC031181 0.32 2.70 NM_025392 Bccip BRCA2 and CDKN1A interacting protein 0.40 2.07 NM_009754 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.42 2.28 NM_008528 Blnk B-cell linker 0.32 2.11 NM_009764 Brca1 Breast cancer 1 0.40 2.81 Budding uninhibited by benzimidazoles 1 homolog, beta NM_009773 Bub1b (S. cerevisiae) 0.36 2.03 NM_001008705 Bud31 BUD31 homolog (yeast) 0.27 2.20 NM_175696 C530028O21Rik RIKEN cDNA C530028O21 gene 0.43 2.04 Calcium channel, voltage-dependent, L type, alpha 1C NM_009781 Cacna1c subunit 0.41 2.74 NM_019430 Cacng3 Calcium channel, voltage-dependent, gamma subunit 3 0.37 2.02 NM_007586 Calb2 Calbindin 2 0.23 7.20 NM_145595 Cbr4 Carbonyl reductase 4 0.42 3.24 NM_026964 Ccdc124 Coiled-coil domain containing 124 0.36 2.67 NM_175430 Ccdc40 Coiled-coil domain containing 40 0.37 3.65 NM_026186 Ccdc49 Coiled-coil domain containing 49 0.42 2.90 NM_029256 Ccdc83 Coiled-coil domain containing 83 0.30 3.04 NM_023731 Ccdc86 Coiled-coil domain containing 86 0.26 2.07

199 NM_009827 Cckar Cholecystokinin A receptor 0.37 2.14 NM_009853 Cd68 CD68 antigen 0.38 3.00 NM_001008420 Cdh12 Cadherin 12 0.43 2.72 NM_026373 Cdk2ap2 CDK2-associated protein 2 0.33 2.20 NM_133960 Ces6 Carboxylesterase 6 0.45 2.27 NM_007691 Chek1 Checkpoint kinase 1 homolog (S. pombe) 0.36 2.26 NM_026885 Chmp2a Chromatin modifying protein 2A 0.40 1.97 CLP1, cleavage and polyadenylation factor I subunit, NM_133840 Clp1 homolog (S. cerevisiae) 0.45 2.07 NM_009191 Clpb ClpB caseinolytic peptidase B homolog (E. coli) 0.33 2.15 CKLF-like MARVEL transmembrane domain NM_153582 Cmtm4 containing 4 0.40 2.05 NM_133724 Cno Cappuccino 0.40 2.64 NM_212484 Cnot6 CCR4-NOT transcription complex, subunit 6 0.33 2.02 NM_026562 Cntd1 Cyclin N-terminal domain containing 1 0.42 2.17 NM_019817 Copz1 Coatomer protein complex, subunit zeta 1 0.28 2.07 NM_001024926 Cyb5d2 Cytochrome b5 domain containing 2 0.23 2.90 DNA segment, Chr 6, Wayne State University 163, NM_138594 D6Wsu163e expressed 0.45 2.95 NM_026538 Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.45 2.30 NM_172689 Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.40 2.74 NM_145157 Defb19 Defensin beta 19 0.41 3.25 NM_153551 Dennd1c DENN/MADD domain containing 1C 0.41 1.95 NM_026082 Dock7 Dedicator of cytokinesis 7 0.43 1.99 NM_176913 Dpep2 Dipeptidase 2 0.38 2.13 NM_027193 Dph5 DPH5 homolog (S. cerevisiae) 0.42 2.09 NM_026598 Ebpl Emopamil binding protein-like 0.44 2.18 NM_001037923 EG624866 Predicted gene, EG624866 0.40 1.95 NM_007924 Ell Elongation factor RNA polymerase II 0.24 2.35 ELOVL family member 5, elongation of long chain fatty NM_134255 Elovl5 acids (yeast) 0.43 2.60 NM_007951 Erh Enhancer of rudimentary homolog (Drosophila) 0.28 2.05 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide 0.26 2.19 NM_015791 Fbxo8 F-box protein 8 0.45 2.32 NM_010198 Fgf11 Fibroblast growth factor 11 0.38 1.96 NM_019873 Fkbpl FK506 binding protein-like 0.41 2.30 NM_021899 Foxj2 Forkhead box J2 0.43 2.27 NM_019740 Foxo3a Forkhead box O3a 0.39 3.22 NM_031261 Fthl17 Ferritin, heavy polypeptide-like 17 0.32 2.27 NM_148925 Fyco1 FYVE and coiled-coil domain containing 1 0.42 2.65 NM_010269 Gdap2 Ganglioside-induced differentiation-associated-protein 2 0.40 2.18 NM_013528 Gfpt1 Glutamine fructose-6-phosphate transaminase 1 0.33 1.97 NM_019832 Gkap1 G kinase anchoring protein 1 0.42 2.45 NM_033320 Glce Glucuronyl C5-epimerase 0.39 3.03 NM_001033407 Gm815 Gene model 815, (NCBI) 0.41 2.02 NM_153394 Gpr156 G protein-coupled receptor 156 0.15 2.09 NM_008154 Gpr3 G-protein coupled receptor 3 0.32 2.57 NM_001031667 Gsk3a Glycogen synthase kinase 3 alpha 0.30 2.58 NM_181410 Gtf2h3 General transcription factor IIH, polypeptide 3 0.33 1.98 NM_148928 Gtf3c5 General transcription factor IIIC, polypeptide 5 0.44 2.03 NM_177923 H2-M10.2 Histocompatibility 2, M region locus 10.2 0.45 2.07 NM_198962 Hcrtr2 Hypocretin (orexin) receptor 2 0.42 3.21 NM_001033432 Heca Headcase homolog (Drosophila) 0.41 2.01 NM_010454 Hoxa6 Homeo box A6 0.44 2.33 NM_031177 Ift122 Intraflagellar transport 122 homolog (Chlamydomonas) 0.37 2.75 NM_134126 Ift140 Intraflagellar transport 140 homolog (Chlamydomonas) 0.35 2.22 NM_009879 Ift81 Intraflagellar transport 81 homolog (Chlamydomonas) 0.42 2.02 NM_008364 Il1rap Interleukin 1 receptor accessory protein 0.37 2.11 Potassium voltage-gated channel, Shal-related family, NM_019697 Kcnd2 member 2 0.45 2.07 Potassium voltage-gated channel, Isk-related subfamily, NM_008424 Kcne1 member 1 0.34 2.05 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 0.43 1.96 NM_134073 Kctd9 Potassium channel tetramerisation domain containing 9 0.40 1.98

200 NM_134471 Kif2c Kinesin family member 2C 0.35 2.16 NM_025707 Klhl28 Kelch-like 28 (Drosophila) 0.31 2.08 NM_010673 Krtap6-2 Keratin associated protein 6-2 0.38 2.09 NM_001024526 Larp4 La ribonucleoprotein domain family, member 4 0.39 2.11 NM_010702 Lect2 Leukocyte cell-derived chemotaxin 2 0.41 2.59 NM_026719 Lmbrd1 LMBR1 domain containing 1 0.42 2.11 NM_023052 LOC100042493 Similar to beta chemokine Exodus-2 0.37 2.15 NM_033325 Loxl2 Lysyl oxidase-like 2 0.37 2.74 NM_026648 Lrrc50 Leucine rich repeat containing 50 0.38 2.15 NM_022012 Map3k11 Mitogen activated protein kinase kinase kinase 11 0.29 2.26 NM_011948 Map3k4 Mitogen activated protein kinase kinase kinase 4 0.37 2.03 Minichromosome maintenance deficient 5, cell division NM_008566 Mcm5 cycle 46 (S. cerevisiae) 0.40 2.11 NM_025297 Mecr Mitochondrial trans-2-enoyl-CoA reductase 0.29 2.14 NM_020048 Med20 Mediator complex subunit 20 0.31 2.29 NM_029662 Mfsd2 Major facilitator superfamily domain containing 2 0.20 3.08 NM_019944 Mnx1 Motor neuron and pancreas homeobox 1 0.31 3.80 NM_025606 Mrpl16 Mitochondrial ribosomal protein L16 0.37 2.45 NM_024177 Mrpl38 Mitochondrial ribosomal protein L38 0.41 2.34 NM_025595 Mrpl51 Mitochondrial ribosomal protein L51 0.42 2.61 NM_023166 Mtvr2 Mammary tumor virus receptor 2 0.33 3.09 NM_013605 Muc1 Mucin 1, transmembrane 0.34 2.16 NM_010846 Mx1 Myxovirus (influenza virus) resistance 1 0.42 2.17 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, NM_025316 Ndufb5 5 0.43 1.95 NM_023739 Nfx1 Nuclear transcription factor, X-box binding 1 0.32 2.14 NM_010920 Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.35 2.33 Nardilysin, N-arginine dibasic convertase, NRD NM_146150 Nrd1 convertase 1 0.44 2.00 NM_153529 Nrn1 Neuritin 1 0.40 2.79 NM_016773 Nucb2 Nucleobindin 2 0.24 2.21 Nudix (nucleoside diphosphate linked moiety X)-type NM_008637 Nudt1 motif 1 0.31 2.05 NM_001011721 Olfr100 Olfactory receptor 100 0.40 2.31 NM_146573 Olfr1002 Olfactory receptor 1002 0.45 2.02 NM_146834 Olfr101 Olfactory receptor 101 0.45 2.29 NM_146283 Olfr1366 Olfactory receptor 1366 0.19 2.56 NM_001011741 Olfr1386 Olfactory receptor 1386 0.37 2.77 NM_020598 Olfr17 Olfactory receptor 17 0.42 2.05 NM_146374 Olfr368 Olfactory receptor 368 0.44 2.19 NM_146710 Olfr398 Olfactory receptor 398 0.40 2.03 NM_147041 Olfr57 Olfactory receptor 57 0.35 2.23 NM_206897 Olfr6 Olfactory receptor 6 0.36 4.06 NM_207147 Olfr813 Olfactory receptor 813 0.34 2.06 NM_025661 Ormdl3 ORM1-like 3 (S. cerevisiae) 0.29 2.18 NM_001003717 Osbpl8 Oxysterol binding protein-like 8 0.45 3.03 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, NM_025939 Paics succinocarboxamide synthetase 0.36 2.53 NM_146169 Paip2b Poly(A) binding protein interacting protein 2B 0.38 1.99 NM_008781 Pax3 Paired box gene 3 0.32 3.87 NM_008782 Pax5 Paired box gene 5 0.37 3.16 NM_009545 Pcgf2 Polycomb group ring finger 2 0.41 2.57 NM_026850 Pdcl3 Phosducin-like 3 0.45 2.24 NM_026441 Pef1 Penta-EF hand domain containing 1 0.34 2.01 NM_011070 Pfdn2 Prefoldin 2 0.40 2.83 NM_153412 Phldb2 Pleckstrin homology-like domain, family B, member 2 0.45 2.06 NM_025928 Pmf1 Polyamine-modulated factor 1 0.45 1.99 NM_001039509 Pnkd Paroxysmal nonkinesiogenic dyskinesia 0.42 1.96 NM_145145 Pomt1 Protein-O-mannosyltransferase 1 0.44 2.51 NM_175363 Pphln1 Periphilin 1 0.40 2.32 NM_133485 Ppp1r14c Protein phosphatase 1, regulatory (inhibitor) subunit 14c 0.25 2.08 NM_138605 Ppp1r3f Protein phosphatase 1, regulatory (inhibitor) subunit 3F 0.45 2.89

201 Protein phosphatase 3, regulatory subunit B, alpha NM_024459 Ppp3r1 isoform (calcineurin B, type I) 0.35 2.14 NM_138602 Praf2 PRA1 domain family 2 0.33 2.39 NM_025596 Prelid1 PRELI domain containing 1 0.34 2.14 NM_011174 Prh1 Proline rich protein HaeIII subfamily 1 0.40 2.11 NM_008925 Prkcsh Protein kinase C substrate 80K-H 0.37 3.33 NM_138659 Prpf8 Pre-mRNA processing factor 8 0.44 2.25 NM_011181 Pscd2 Pleckstrin homology, Sec7 and coiled-coil domains 2 0.27 2.23 NM_011970 Psmb2 Proteasome (prosome, macropain) subunit, beta type 2 0.41 2.02 NM_133949 Ptov1 Prostate tumor over expressed gene 1 0.21 2.03 NM_029391 Rab4b RAB4B, member RAS oncogene family 0.38 2.26 NM_178045 Rassf4 Ras association (RalGDS/AF-6) domain family 4 0.43 2.13 NM_176838 Rbm35b RNA binding motif protein 35b 0.40 1.98 NM_173445 Rccd1 RCC1 domain containing 1 0.40 2.03 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 0.32 2.10 NM_175372 Rdh13 Retinol dehydrogenase 13 (all-trans and 9-cis) 0.45 2.28 NM_023132 Renbp Renin binding protein 0.45 2.20 NM_178615 Rgmb RGM domain family, member B 0.36 2.04 NM_008955 Rhox6 Reproductive homeobox 6 0.34 1.96 NM_027445 Rnf167 Ring finger protein 167 0.43 2.07 NM_001037916 RP23-233B9.8 Hypothetical protein LOC622665 0.32 1.97 NM_052835 Rpl10 Ribosomal protein 10 0.34 2.54 NM_023133 Rps19 Ribosomal protein S19 0.30 1.99 NM_024266 Rps25 Ribosomal protein S25 0.40 2.40 NM_173450 Rpusd2 RNA pseudouridylate synthase domain containing 2 0.42 2.41 NM_130892 Rtn4ip1 Reticulon 4 interacting protein 1 0.45 3.18 NM_009115 S100b S100 protein, beta polypeptide, neural 0.34 2.46 NM_172676 Samd10 Sterile alpha motif domain containing 10 0.25 2.01 NM_172205 Sbsn Suprabasin 0.44 1.96 NM_013928 Schip1 Schwannomin interacting protein 1 0.42 2.25 NM_172596 Sec24c SEC24 related gene family, member C (S. cerevisiae) 0.38 1.99 NM_133210 Sertad3 SERTA domain containing 3 0.30 2.72 NM_009159 Sfrs5 Splicing factor, arginine/serine-rich 5 (SRp40, HRS) 0.35 2.16 Solute carrier family 10 (sodium/bile acid cotransporter NM_145406 Slc10a3 family), member 3 0.44 2.00 NM_011773 Slc30a3 Solute carrier family 30 (zinc transporter), member 3 0.40 2.07 Solute carrier family 37 (glycerol-3-phosphate NM_153062 Slc37a1 transporter), member 1 0.41 2.39 Solute carrier family 3 (activators of dibasic and neutral NM_008577 Slc3a2 amino acid transport), member 2 0.41 2.24 SWI/SNF related, matrix associated, actin dependent NM_011416 Smarca2 regulator of chromatin, subfamily a, member 2 0.38 3.00 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing NM_007958 Smarcad1 DEAD/H box 1` 0.45 2.92 NM_001025612 Snx22 Sorting nexin 22 0.35 2.14 NM_009238 Sox4 SRY-box containing gene 4 0.42 2.43 NM_031183 Sp6 Trans-acting transcription factor 6 0.42 2.64 NM_177867 Spata21 Spermatogenesis associated 21 0.38 2.03 Signal peptidase complex subunit 2 homolog (S. NM_025668 Spcs2 cerevisiae) 0.38 2.32 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 0.36 3.03 NM_145584 Spon1 Spondin 1, (f-spondin) extracellular matrix protein 0.38 2.20 NM_011479 Sptlc2 Serine palmitoyltransferase, long chain base subunit 2 0.43 2.04 NM_020493 Srf Serum response factor 0.43 2.30 Src-related kinase lacking C-terminal regulatory tyrosine NM_011481 Srms and N-terminal myristylation sites 0.40 2.34 NM_146177 Suv420h2 Suppressor of variegation 4-20 homolog 2 (Drosophila) 0.26 2.65 NM_001040435 Tacc3 Transforming, acidic coiled-coil containing protein 3 0.45 2.47 NM_181516 Taz Tafazzin 0.41 2.93 NM_029467 Tcam1 Testicular cell adhesion molecule 1 0.42 2.57 NM_026456 Tceb1 Transcription elongation factor B (SIII), polypeptide 1 0.35 2.08 NM_009359 Tex9 Testis expressed gene 9 0.42 2.11 NM_153552 Thoc1 THO complex 1 0.37 2.24

202 NM_011592 Timm44 Translocase of inner mitochondrial membrane 44 0.34 2.14 NM_029649 Tmem101 Transmembrane protein 101 0.37 3.44 NM_001033393 Tmem104 Transmembrane protein 104 0.35 2.03 NM_028343 Tmem135 Transmembrane protein 135 0.31 2.03 NM_133706 Tmem97 Transmembrane protein 97 0.39 2.13 NM_016788 Tnk2 Tyrosine kinase, non-receptor, 2 0.25 2.01 NM_026654 Toe1 Target of EGR1, member 1 (nuclear) 0.39 2.13 Translocase of outer mitochondrial membrane 40 NM_016871 Tomm40 homolog (yeast) 0.32 2.17 NM_134097 Topors Topoisomerase I binding, arginine/serine-rich 0.43 2.12 NM_001024206 Trappc1 Trafficking protein particle complex 1 0.26 2.02 NM_029979 Trim35 Tripartite motif-containing 35 0.42 2.47 NM_198012 Trim68 Tripartite motif containing 68 0.38 1.98 Transformation related protein 53 inducible nuclear NM_178111 Trp53inp2 protein 2 0.36 2.26 NM_019634 Tspan7 Tetraspanin 7 0.28 2.27 Tumor-suppressing subchromosomal transferable NM_020285 Tssc4 fragment 4 0.36 2.26 NM_021324 Ttyh1 Tweety homolog 1 (Drosophila) 0.45 2.01 NM_018879 Tusc4 Tumor suppressor candidate 4 0.29 2.31 NM_146144 Usp1 Ubiquitin specific peptdiase 1 0.44 2.99 NM_024258 Usp16 Ubiquitin specific peptidase 16 0.25 2.09 NM_178635 Uvrag UV radiation resistance associated gene 0.40 2.76 Valosin containing protein (p97)/p47 complex NM_173443 Vcpip1 interacting protein 1 0.43 1.99 Ventricular zone expressed PH domain homolog 1 NM_145820 Veph1 (zebrafish) 0.32 2.27 NM_133945 Vrk3 Vaccinia related kinase 3 0.44 2.13 NM_172470 Wdr35 WD repeat domain 35 0.42 2.92 NM_178739 Wdr40b WD repeat domain 40B 0.36 2.08 NM_176923 Wdr59 WD repeat domain 59 0.39 2.48 NM_001025375 Wdr61 WD repeat domain 61 0.28 2.51 NM_011723 Xdh Xanthine dehydrogenase 0.43 2.35 NM_177310 Xpnpep3 X-prolyl aminopeptidase (aminopeptidase P) 3, putative 0.24 3.03 NM_172121 Zc3h3 Zinc finger CCCH type containing 3 0.38 2.60 NM_026846 Zfand2b Zinc finger, AN1 type domain 2B 0.35 2.21 NM_145547 Zfp189 Zinc finger protein 189 0.23 1.98 NM_146221 Zfp426 Zinc finger protein 426 0.42 2.16 NM_001001186 Zfp456 Zinc finger protein 456 0.42 2.10 NM_024215 Zfp593 Zinc finger protein 593 0.26 2.58 NM_144523 Zfp622 Zinc finger protein 622 0.28 3.24 NM_001005788 Zfp69 Zinc finger protein 69 0.44 2.09 NM_145916 Zfp7 Zinc finger protein 7 0.44 1.98 NM_028913 Zfp819 Zinc finger protein 819 0.43 2.03 NM_011769 Zim1 Zinc finger, imprinted 1 0.38 2.45 NM_025472 0.36 3.35 NM_026297 0.22 4.14 NM_198646 0.41 2.19 NM_028793 0.24 3.30 NM_001040398 0.35 2.36 NM_027681 0.45 2.09 NM_001033377 0.43 2.26

SUPPLEMENTAL TABLE S16: Genes Demonstrating Reversal of Increased Phospho-CREB Binding by Imipramine in the Social Defeat Model (p<0.001)

Defeat + Defeat Fold Imipramine Fold Accession Number Symbol Name Change Change NM_025946 2010100O12Rik RIKEN cDNA 2010100O12 gene 2.47 0.50 NM_001025573 2010107G12Rik RIKEN cDNA 2010107G12 gene 2.68 0.44 NM_172398 2310005E10Rik RIKEN cDNA 2310005E10 gene 2.26 0.49 NM_025865 2310030G06Rik RIKEN cDNA 2310030G06 gene 2.13 0.42

203 NM_025874 2310076L09Rik RIKEN cDNA 2310076L09 gene 2.18 0.46 NM_026643 2410017P07Rik RIKEN cDNA 2410017P07 gene 2.32 0.35 NM_025997 2610204K14Rik RIKEN cDNA 2610204K14 gene 2.95 0.41 NM_183287 2610318N02Rik RIKEN cDNA 2610318N02 gene 2.29 0.50 NM_027568 4733401H21Rik RIKEN cDNA 4733401H21 gene 2.91 0.41 NM_178388 4930425N13Rik RIKEN cDNA 4930425N13 gene 2.33 0.37 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 3.86 0.29 NM_027631 4931407G18Rik RIKEN cDNA 4931407G18 gene 2.13 0.50 NM_025744 4933404M02Rik RIKEN cDNA 4933404M02 gene 2.50 0.44 NM_177314 5330439B14Rik RIKEN cDNA 5330439B14 gene 2.59 0.48 NM_146091 5730596K20Rik RIKEN cDNA 5730596K20 gene 2.54 0.49 NM_001033383 6430526N21Rik RIKEN cDNA 6430526N21 gene 2.99 0.51 NM_172930 6430550H21Rik RIKEN cDNA 6430550H21 gene 2.99 0.48 NM_001039720 9030619P08Rik RIKEN cDNA 9030619P08 gene 2.87 0.36 NM_176849 9430010O03Rik RIKEN cDNA 9430010O03 gene 2.65 0.43 NM_175687 A230050P20Rik RIKEN cDNA A230050P20 gene 2.22 0.49 NM_001033163 Abhd9 Abhydrolase domain containing 9 2.13 0.45 NM_080633 Aco2 Aconitase 2, mitochondrial 2.17 0.47 NM_013455 Acr Preproacrosin 2.53 0.30 NM_007402 Adam7 A disintegrin and metallopeptidase domain 7 2.58 0.44 NM_178873 Adck2 AarF domain containing kinase 2 2.48 0.49 Alcohol dehydrogenase 7 (class IV), mu or sigma NM_009626 Adh7 polypeptide 3.03 0.47 NM_027373 Afap1 Actin filament associated protein 1 2.11 0.51 NM_173016 AI427515 Expressed sequence AI427515 2.41 0.44 NM_001033199 AI747448 Expressed sequence AI747448 2.11 0.52 NM_007432 Akp3 Alkaline phosphatase 3, intestine, not Mn requiring 2.45 0.43 NM_013467 Aldh1a1 Aldehyde dehydrogenase family 1, subfamily A1 3.12 0.39 NM_172532 Aldh5a1 Aldhehyde dehydrogenase family 5, subfamily A1 2.52 0.51 NM_144903 Aldob Aldolase 2, B isoform 2.73 0.38 NM_172935 Amdhd2 Amidohydrolase domain containing 2 2.19 0.45 NM_153319 Amot Angiomotin 2.41 0.42 NM_028779 Ampd2 Adenosine monophosphate deaminase 2 (isoform L) 2.12 0.48 NM_007449 Ang2 Angiogenin, ribonuclease A family, member 2 2.34 0.49 NM_178655 Ank2 Ankyrin 2, brain 2.17 0.48 NM_172262 Aof1 Amine oxidase, flavin containing 1 2.50 0.42 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 3.72 0.49 NM_182994 Arl5a ADP-ribosylation factor-like 5A 2.11 0.42 NM_019717 Arl6ip2 ADP-ribosylation factor-like 6 interacting protein 2 2.27 0.50 NM_080467 Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 2.17 0.50 NM_015732 Axin2 Axin2 2.19 0.51 NM_194347 AY358078 CDNA sequence AY358078 2.19 0.44 NM_080640 Baalc Brain and acute leukemia, cytoplasmic 2.56 0.48 NM_178446 BC013481 CDNA sequence BC013481 3.19 0.36 NM_146215 BC025546 CDNA sequence BC025546 2.30 0.32 NM_198301 BC052328 CDNA sequence BC052328 2.20 0.49 NM_145635 BC054059 CDNA sequence BC054059 2.13 0.50 NM_001033001 BC065397 CDNA sequence BC065397 2.88 0.35 NM_013867 Bcar3 Breast cancer anti-estrogen resistance 3 2.26 0.46 NM_009756 Bmp10 Bone morphogenetic protein 10 2.69 0.42 NM_080708 Bmp2k BMP2 inducible kinase 2.13 0.46 NM_138678 Butr1 Butyrophilin related 1 2.58 0.37 NM_009778 C3 Complement component 3 2.12 0.51 NM_007583 Cacng2 Calcium channel, voltage-dependent, gamma subunit 2 2.26 0.51 NM_028296 Car10 Carbonic anhydrase 10 3.02 0.46 NM_007617 Cav3 Caveolin 3 2.36 0.42 NM_001033654 Ccdc139 Coiled-coil domain containing 139 3.09 0.38 NM_026070 Ccdc53 Coiled-coil domain containing 53 2.24 0.49 NM_201372 Ccdc84 Coiled-coil domain containing 84 2.73 0.38 NM_172405 Ccdc98 Coiled-coil domain containing 98 2.11 0.31 NM_011333 Ccl2 Chemokine (C-C motif) ligand 2 2.49 0.39 NM_001013412 Ccl26l Chemokine (C-C motif) ligand 26-like 2.42 0.46 NM_144943 Cd207 CD 207 antigen 2.16 0.49 NM_027276 Cdc16 CDC16 cell division cycle 16 homolog (S. cerevisiae) 2.25 0.39

204 NM_198164 Cdc2l6 Cell division cycle 2-like 6 (CDK8-like) 2.29 0.46 Cyclin-dependent kinase inhibitor 2C (p18, inhibits NM_007671 Cdkn2c CDK4) 2.60 0.51 NM_001037136 Centg2 Centaurin, gamma 2 2.76 0.43 NM_015780 Cfhr1 Complement factor H-related 1 2.42 0.48 NM_018818 Chm Choroidermia 2.12 0.45 NM_029633 Clasp2 CLIP associating protein 2 2.27 0.33 NM_016877 Cnot4 CCR4-NOT transcription complex, subunit 4 2.54 0.46 NM_172687 Coq3 Coenzyme Q3 homolog, methyltransferase (yeast) 2.47 0.48 NM_028798 Crct1 Cysteine-rich C-terminal 1 2.81 0.43 CTD (carboxy-terminal domain, RNA polymerase II, NM_212450 Ctdspl2 polypeptide A) small phosphatase like 2 2.12 0.49 NM_028288 Cul4b Cullin 4B 3.81 0.26 NM_177382 Cyp2r1 Cytochrome P450, family 2, subfamily r, polypeptide 1 2.15 0.49 NM_177307 Cyp4f39 Cytochrome P450, family 4, subfamily f, polypeptide 39 3.23 0.32 NM_001037999 Dbi Diazepam binding inhibitor 2.25 0.31 NM_027030 Dcps Decapping enzyme, scavenger 2.27 0.30 NM_010029 Ddx4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 4.49 0.23 NM_007843 Defb1 Defensin beta 1 2.68 0.39 NM_001034910 Defb42 Defensin beta 42 2.25 0.50 NM_030734 Defb5 Defensin beta 5 2.48 0.49 NM_001025296 Dffa DNA fragmentation factor, alpha subunit 2.79 0.43 NM_001025947 Dnm1l Dynamin 1-like 2.88 0.31 NM_013504 Dsc1 Desmocollin 1 3.30 0.44 NM_001039556 E130016E03Rik RIKEN cDNA E130016E03 gene 2.46 0.51 NM_001013368 E2f8 E2F transcription factor 8 2.28 0.46 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 2.50 0.32 NM_172504 EG212225 Predicted gene, EG212225 2.25 0.39 NM_177849 EG329541 Predicted gene, EG329541 2.91 0.47 Enoyl-Coenzyme A, hydratase/3-hydroxyacyl NM_023737 Ehhadh Coenzyme A dehydrogenase 2.41 0.51 NM_010135 Enah Enabled homolog (Drosophila) 2.46 0.40 NM_027123 Fastkd3 FAST kinase domains 3 2.16 0.42 NM_175530 Fbxo46 F-box protein 46 2.72 0.44 NM_019873 Fkbpl FK506 binding protein-like 2.24 0.42 NM_144878 Fmo4 Flavin containing monooxygenase 4 2.31 0.47 NM_027402 Fndc5 Fibronectin type III domain containing 5 2.16 0.39 NM_019468 G6pd2 Glucose-6-phosphate dehydrogenase 2 2.89 0.49 NM_178028 Galp Galanin-like peptide precursor 2.23 0.51 NM_028407 Gcap14 Granule cell antiserum positive 14 2.20 0.50 Glucosaminyl (N-acetyl) transferase 2, I-branching NM_133219 Gcnt2 enzyme 2.29 0.43 NM_144786 Ggtl3 Gamma-glutamyltransferase-like 3 2.24 0.47 NM_008123 Gja8 Gap junction membrane channel protein alpha 8 3.46 0.32 NM_008141 Gnat2 Guanine nucleotide binding protein, alpha transducing 2 2.48 0.44 Guanine nucleotide binding protein (G protein), gamma NM_010314 Gngt1 transducing activity polypeptide 1 2.89 0.42 NM_001035122 Golm1 Golgi membrane protein 1 2.43 0.31 NM_008172 Grin2d Glutamate receptor, ionotropic, NMDA2D (epsilon 4) 2.57 0.49 NM_008181 Gsta1 Glutathione S-transferase, alpha 1 (Ya) 2.21 0.49 NM_010360 Gstm5 Glutathione S-transferase, mu 5 2.77 0.38 NM_008178 Gsx1 GS homeobox 1 3.94 0.30 NM_133256 Gsx2 GS homeobox 2 2.43 0.49 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 2.16 0.35 NM_010364 Gtf2h4 General transcription factor II H, polypeptide 4 2.15 0.42 NM_010293 Gykl1 Glycerol kinase-like 1 2.82 0.45 NM_010381 H2-Ea Histocompatibility 2, class II antigen E alpha 2.22 0.50 NM_144835 Heatr1 HEAT repeat containing 1 2.41 0.44 NM_177171 Heatr5a HEAT repeat containing 5A 3.88 0.42 Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain NM_010418 Herc2 (RLD) 2 2.26 0.46 NM_010432 Hipk1 Homeodomain interacting protein kinase 1 2.58 0.42 NM_172746 Hirip3 HIRA interacting protein 3 2.44 0.39

205 NM_023422 Hist1h2bc Histone cluster 1, H2bc 2.82 0.34 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and NM_008295 Hsd3b5 steroid delta-isomerase 5 3.00 0.40 NM_028957 Hyal5 Hyaluronoglucosaminidase 5 2.30 0.29 NM_026601 Hyi Hydroxypyruvate isomerase homolog (E. coli) 2.56 0.35 NM_011940 Ifi202b Interferon activated gene 202B 2.89 0.47 NM_183029 Igf2bp2 Insulin-like growth factor 2 mRNA binding protein 2 2.46 0.42 NM_008343 Igfbp3 Insulin-like growth factor binding protein 3 2.31 0.51 NM_008366 Il2 Interleukin 2 2.89 0.40 NM_013563 Il2rg Interleukin 2 receptor, gamma chain 4.24 0.25 NM_010556 Il3 Interleukin 3 3.14 0.43 NM_008370 Il5ra Interleukin 5 receptor, alpha 4.09 0.37 NM_027927 Ints12 Integrator complex subunit 12 2.44 0.47 NM_001001309 Itga8 Integrin alpha 8 2.70 0.43 NM_011365 Itsn2 Intersectin 2 2.36 0.38 Potassium voltage-gated channel, subfamily G, member NM_025734 Kcng4 4 2.22 0.46 Potassium voltage-gated channel, subfamily H (eag- NM_172805 Kcnh5 related), member 5 5.27 0.38 Potassium voltage-gated channel, subfamily H (eag- NM_001031811 Kcnh8 related), member 8 2.17 0.49 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 4.54 0.23 NM_010629 Kifap3 Kinesin-associated protein 3 4.02 0.21 NM_010648 Klra3 Killer cell lectin-like receptor, subfamily A, member 3 2.14 0.44 NM_008526 Klrb1d Killer cell lectin-like receptor subfamily B member 1D 5.09 0.31 NM_010659 Krt31 Keratin 31 2.28 0.46 NM_001039666 Krt40 Keratin 40 2.29 0.42 NM_010695 Lcn4 Lipocalin 4 2.56 0.43 NM_026719 Lmbrd1 LMBR1 domain containing 1 3.21 0.34 NM_177178 Lmbrd2 LMBR1 domain containing 2 2.54 0.46 NM_019390 Lmna Lamin A 2.31 0.48 NM_207222 Lmo3 LIM domain only 3 2.38 0.44 NM_022882 Lpin2 Lipin 2 2.42 0.38 Leucine-rich repeats and calponin homology (CH) NM_001033439 Lrch1 domain containing 1 2.65 0.41 NM_178725 Lrrc4c Leucine rich repeat containing 4C 2.82 0.39 NM_133688 Lyrm5 LYR motif containing 5 2.14 0.36 NM_017372 Lyzs Lysozyme 2.20 0.36 NM_011839 Mab21l2 Mab-21-like 2 (C. elegans) 2.70 0.48 NM_175296 Mael Maelstrom homolog (Drosophila) 2.18 0.46 NM_026859 Maf1 MAF1 homolog (S. cerevisiae) 3.09 0.40 NM_001038609 Mapt Microtubule-associated protein tau 2.26 0.51 NM_134012 Mbtd1 Mbt domain containing 1 2.36 0.30 NM_008563 Mcm3 Minichromosome maintenance deficient 3 (S. cerevisiae) 2.51 0.37 NM_010782 Mcpt9 Mast cell protease 9 3.56 0.46 NM_144913 Mepce Methylphosphate capping enzyme 5.02 0.47 NM_001039214 Mex3c Mex3 homolog C (C. elegans) 2.82 0.22 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 2.34 0.41 NM_011746 Mkrn3 Makorin, ring finger protein, 3 2.35 0.29 NM_013826 Mocs2 Molybdenum cofactor synthesis 2 2.65 0.45 NM_198162 Morc2a Microrchidia 2A 2.17 0.51 Mdm2, transformed 3T3 cell double minute p53 binding NM_134092 Mtbp protein 2.16 0.31 NM_027134 Mtfmt Mitochondrial methionyl-tRNA formyltransferase 3.03 0.20 NM_028860 Mtmr3 Myotubularin related protein 3 2.65 0.28 Alpha-N-acetylglucosaminidase (Sanfilippo disease NM_013792 Naglu IIIB) 2.44 0.40 NM_153126 Nat10 N-acetyltransferase 10 2.17 0.38 NM_010874 Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.78 0.43 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, NM_023172 Ndufb9 9 3.59 0.29 NM_025424 Nenf Neuron derived neurotrophic factor 2.41 0.44 Nuclear factor of activated T-cells, cytoplasmic, NM_010901 Nfatc3 calcineurin-dependent 3 3.33 0.50 NM_181547 Nostrin Nitric oxide synthase trafficker 2.86 0.49

206 NM_009108 Nr1h4 Nuclear receptor subfamily 1, group H, member 4 2.97 0.44 NM_134122 Nrm Nurim (nuclear envelope membrane protein) 2.55 0.43 NM_026330 Nsmce1 Non-SMC element 1 homolog (S. cerevisiae) 2.18 0.51 NM_026746 Nsmce2 Non-SMC element 2 homolog (MMS21, S. cerevisiae) 2.49 0.51 NM_026004 Nt5c3 5'-nucleotidase, cytosolic III 2.20 0.36 Nuclear undecaprenyl pyrophosphate synthase 1 NM_030250 Nus1 homolog (S. cerevisiae) 2.20 0.43 NM_146921 Olfr1 Olfactory receptor 1 2.56 0.48 NM_001011836 Olfr1129 Olfactory receptor 1129 2.37 0.52 NM_146753 Olfr1195 Olfactory receptor 1195 2.25 0.50 NM_146794 Olfr1263 Olfactory receptor 1263 2.27 0.44 NM_146404 Olfr1289 Olfactory receptor 1289 4.97 0.25 NM_146403 Olfr1295 Olfactory receptor 1295 2.93 0.39 NM_146362 Olfr1312 Olfactory receptor 1312 2.15 0.41 NM_146678 Olfr1428 Olfactory receptor 1428 2.41 0.50 NM_146989 Olfr1496 Olfactory receptor 1496 2.25 0.45 NM_146432 Olfr1512 Olfactory receptor 1512 2.28 0.51 NM_147001 Olfr172 Olfactory receptor 172 2.40 0.48 NM_001011778 Olfr257 Olfactory receptor 257 2.37 0.37 NM_147036 Olfr283 Olfactory receptor 283 2.52 0.35 NM_146938 Olfr346 Olfactory receptor 346 2.46 0.47 NM_001011863 Olfr406 Olfactory receptor 406 2.87 0.34 NM_001011528 Olfr456 Olfactory receptor 456 2.13 0.50 NM_146583 Olfr52 Olfactory receptor 52 2.59 0.51 NM_001001805 Olfr576 Olfactory receptor 576 3.63 0.42 NM_147115 Olfr578 Olfactory receptor 578 3.26 0.35 NM_147081 Olfr610 Olfactory receptor 610 2.14 0.52 NM_001011518 Olfr94 Olfactory receptor 94 2.61 0.45 NM_146510 Olfr98 Olfactory receptor 98 2.78 0.52 NM_146515 Olfr99 Olfactory receptor 99 2.16 0.46 NM_205822 Omt2b Oocyte maturation, beta 2.39 0.50 NM_198661 Oog2 Oogenesin 2 2.48 0.30 NM_027950 Osgin1 Oxidative stress induced growth inhibitor 1 2.78 0.27 NM_001025244 OTTMUSG00000002177 Predicted gene, OTTMUSG00000002177 2.17 0.44 NM_177865 OTTMUSG00000008540 Predicted gene, OTTMUSG00000008540 2.84 0.48 NM_177460 Parp16 Poly (ADP-ribose) polymerase family, member 16 2.15 0.38 NM_030253 Parp9 Poly (ADP-ribose) polymerase family, member 9 2.31 0.49 NM_033587 Pcdhga12 Protocadherin gamma subfamily A, 12 2.16 0.51 NM_033583 Pcdhga12 Protocadherin gamma subfamily A, 12 3.02 0.35 NM_011067 Per3 Period homolog 3 (Drosophila) 2.68 0.50 NM_144896 Pet112l PET112-like (yeast) 2.15 0.49 NM_145122 Pex16 Peroxisome biogenesis factor 16 2.26 0.46 NM_001013369 Pfdn4 Prefoldin 4 2.50 0.43 NM_029293 Phpt1 Phosphohistidine phosphatase 1 2.94 0.34 NM_172992 Phtf2 Putative homeodomain transcription factor 2 2.59 0.46 Phosphatidylinositol 3-kinase, C2 domain containing, NM_011084 Pik3c2g gamma polypeptide 2.17 0.44 NM_013631 Pklr Pyruvate kinase liver and red blood cell 2.57 0.34 NM_011099 Pkm2 Pyruvate kinase, muscle 2.39 0.45 NM_011123 Plp1 Proteolipid protein (myelin) 1 2.61 0.50 NM_172683 Pogz Pogo transposable element with ZNF domain 2.87 0.51 NM_007548 Prdm1 PR domain containing 1, with ZNF domain 2.49 0.48 NM_011174 Prh1 Proline rich protein HaeIII subfamily 1 2.89 0.34 NM_031499 Prh1 Proline rich protein HaeIII subfamily 1 2.81 0.43 Protein kinase, AMP-activated, beta 2 non-catalytic NM_182997 Prkab2 subunit 2.59 0.52 Protein kinase, AMP-activated, gamma 3 non-catatlytic NM_153745 Prkag3 subunit 2.64 0.42 NM_008926 Prkg2 Protein kinase, cGMP-dependent, type II 2.11 0.48 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 2.21 0.43 NM_181852 Prl2c5 Prolactin family 2, subfamily c, member 5 2.28 0.44 NM_011168 Prl7a2 Prolactin family 7, subfamily a, member 2 2.26 0.45 NM_011120 Prl7d1 Prolactin family 7, subfamily d, member 1 2.58 0.47 NM_133182 Prmt2 Protein arginine N-methyltransferase 2 2.81 0.52

207 NM_008937 Prox1 Prospero-related homeobox 1 2.79 0.50 NM_008941 Prss7 Protease, serine, 7 (enterokinase) 2.12 0.45 NM_133351 Prss8 Protease, serine, 8 (prostasin) 2.11 0.47 NM_028195 Pscd4 Pleckstrin homology, Sec7 and coiled/coil domains 4 2.18 0.33 NM_011966 Psma4 Proteasome (prosome, macropain) subunit, alpha type 4 2.89 0.39 Proteasome (prosome, macropain) 26S subunit, non- NM_026545 Psmd8 ATPase, 8 2.41 0.46 NM_011877 Ptpn21 Protein tyrosine phosphatase, non-receptor type 21 2.55 0.29 NM_029928 Ptprb Protein tyrosine phosphatase, receptor type, B 2.31 0.40 NM_181395 Pxdn Peroxidasin homolog (Drosophila) 3.80 0.45 NM_153559 Qsox2 Quiescin Q6 sulfhydryl oxidase 2 2.11 0.50 NM_001033172 Rab11fip2 RAB11 family interacting protein 2 (class I) 2.34 0.44 NM_175112 Rae1 RAE1 RNA export 1 homolog (S. pombe) 2.28 0.47 NM_011249 Rbl1 Retinoblastoma-like 1 (p107) 2.51 0.45 NM_009044 Rel Reticuloendotheliosis oncogene 2.26 0.39 NM_009062 Rgs4 Regulator of G-protein signaling 4 2.23 0.48 Required for meiotic nuclear division 1 homolog (S. NM_025343 Rmnd1 cerevisiae) 2.90 0.46 NM_001011877 Rnase11 Ribonuclease, RNase A family, 11 (non-active) 2.12 0.43 Ribonuclease L (2', 5'-oligoisoadenylate synthetase- NM_011882 Rnasel dependent) 2.13 0.51 NM_033604 Rnf111 Ring finger 111 3.15 0.35 NM_019642 Rpn2 Ribophorin II 2.64 0.32 NM_001013376 Rpp38 Ribonuclease P/MRP 38 subunit (human) 2.82 0.38 NM_178376 Rraga Ras-related GTP binding A 2.39 0.45 NM_172566 Rundc1 RUN domain containing 1 2.19 0.49 NM_199422 S100a7a S100 calcium binding protein A7A 2.22 0.49 NM_020483 Sap30bp SAP30 binding protein 2.53 0.31 NM_007644 Scarb2 Scavenger receptor class B, member 2 3.45 0.41 NM_013883 Scmh1 Sex comb on midleg homolog 1 2.27 0.40 NM_134091 Sgsm3 Small G protein signaling modulator 3 2.44 0.46 NM_012009 Sh2d1b1 SH2 domain protein 1B1 2.24 0.50 NM_172937 Shprh SNF2 histone linker PHD RING helicase 2.30 0.43 Sirtuin 2 (silent mating type information regulation 2, NM_022432 Sirt2 homolog) 2 (S. cerevisiae) 8.61 0.30 NM_011384 Six6 Sine oculis-related homeobox 6 homolog (Drosophila) 2.42 0.41 NM_029444 Six6os1 Six6 opposite strand transcript 1 2.24 0.46 Solute carrier family 13 (sodium/sulfate symporters), NM_172892 Slc13a4 member 4 2.31 0.52 Solute carrier family 29 (nucleoside transporters), NM_146257 Slc29a4 member 4 3.04 0.48 NM_080854 Slc34a3 Solute carrier family 34 (sodium phosphate), member 3 3.03 0.39 Solute carrier family 7 (cationic amino acid transporter, NM_007515 Slc7a3 y+ system), member 3 2.24 0.39 Solute carrier family 9 (sodium/hydrogen exchanger), NM_177353 Slc9a7 isoform 7 2.42 0.50 NM_029273 Slitrk5 SLIT and NTRK-like family, member 5 2.41 0.48 NM_134034 Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 2.92 0.39 NM_176996 Smo Smoothened homolog (Drosophila) 2.34 0.46 NM_013669 Snap91 Synaptosomal-associated protein 91 2.24 0.43 NM_172926 Snx14 Sorting nexin 14 2.17 0.41 NM_011444 Sox5 SRY-box containing gene 5 2.97 0.38 NM_028852 Spatc1 Spermatogenesis and centriole associated 1 2.24 0.37 NM_182990 Ssrp1 Structure specific recognition protein 1 2.18 0.30 NM_024270 Stard3nl STARD3 N-terminal like 2.24 0.51 NM_178749 Stk32a Serine/threonine kinase 32A 2.13 0.46 NM_172294 Sulf1 Sulfatase 1 2.69 0.48 NM_016771 Sult1d1 Sulfotransferase family 1D, member 1 2.18 0.48 NM_022724 Suv39h2 Suppressor of variegation 3-9 homolog 2 (Drosophila) 2.22 0.39 NM_028052 Synpr Synaptoporin 4.23 0.39 NM_207029 Tas2r129 Taste receptor, type 2, member 129 2.45 0.46 NM_032005 Tbx19 T-box 19 2.23 0.42 NM_026305 Tceb2 Transcription elongation factor B (SIII), polypeptide 2 3.51 0.33 NM_013688 Tcte1 T-complex-associated testis expressed 1 3.79 0.44

208 NM_009367 Tgfb2 Transforming growth factor, beta 2 2.19 0.50 NM_054089 Tgs1 Trimethylguanosine synthase homolog (S. cerevisiae) 3.16 0.50 NM_178060 Thra Thyroid hormone receptor alpha 2.19 0.46 Translocase of inner mitochondrial membrane 8 NM_013897 Timm8b homolog b (yeast) 3.85 0.46 NM_172998 Tmem118 Transmembrane protein 118 3.37 0.35 NM_019432 Tmem37 Transmembrane protein 37 2.70 0.47 NM_177102 Tmem91 Transmembrane protein 91 3.42 0.38 NM_009403 Tnfsf8 Tumor necrosis factor (ligand) superfamily, member 8 2.62 0.43 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein 3.22 0.49 NM_175114 Trak1 Trafficking protein, kinesin binding 1 2.58 0.34 NM_001024206 Trappc1 Trafficking protein particle complex 1 2.78 0.39 NM_197987 Trim37 Tripartite motif protein 37 3.81 0.31 NM_001013616 Trim6 Tripartite motif protein 6 2.66 0.40 NM_001033429 Trim75 Tripartite motif-containing 75 2.37 0.51 NM_011640 Trp53 Transformation related protein 53 2.43 0.40 TRNA splicing endonuclease 2 homolog (SEN2, S. NM_199033 Tsen2 cerevisiae) 2.16 0.51 NM_011654 Tuba1b Tubulin, alpha 1B 2.46 0.49 NM_011655 Tubb5 Tubulin, beta 5 2.76 0.38 NM_177823 Ubash3a Ubiquitin associated and SH3 domain containing, A 2.91 0.51 NM_019562 Uchl5 Ubiquitin carboxyl-terminal esterase L5 2.66 0.26 NM_011671 Ucp2 Uncoupling protein 2 (mitochondrial, proton carrier) 3.30 0.36 NM_134231 V1re12 Vomeronasal 1 receptor, E12 2.11 0.51 NM_134196 V1re7 Vomeronasal 1 receptor, E7 2.19 0.48 NM_145842 V1re9 Vomeronasal 1 receptor, E9 3.24 0.32 NM_134217 V1rh8 Vomeronasal 1 receptor, H8 3.61 0.25 NM_009493 V2r4 Vomeronasal 2, receptor, 4 2.30 0.49 NM_011701 Vim Vimentin 2.96 0.36 NM_011702 Vip Vasoactive intestinal polypeptide 2.39 0.42 NM_172445 Wdr37 WD repeat domain 37 2.83 0.40 NM_181400 Wdr47 WD repeat domain 47 2.25 0.52 NM_026323 Wfdc2 WAP four-disulfide core domain 2 2.17 0.49 NM_016875 Ybx2 Y box protein 2 2.17 0.24 NM_028325 Zcchc12 Zinc finger, CCHC domain containing 12 3.23 0.37 NM_017467 Zfp316 Zinc finger protein 316 5.49 0.45 NM_001013745 Zfp57 Zinc finger protein 57 3.10 0.32 NM_133228 Zfp87 Zinc finger protein 87 2.12 0.50 NM_011763 Zfp9 Zinc finger protein 9 2.22 0.40 NM_026107 Zkscan6 Zinc finger with KRAB and SCAN domains 6 2.56 0.32 NM_146422 3.32 0.38 NM_177177 2.32 0.50 NM_172419 3.05 0.30 NM_001033152 2.22 0.41 NM_177008 2.36 0.52 NM_026649 4.59 0.27 NM_207226 2.58 0.47 NM_001008702 2.36 0.47 NM_133695 2.77 0.49 NM_001033809 2.69 0.47 NM_001037169 2.48 0.41 NM_019427 2.85 0.35 NM_178391 2.42 0.29 NM_177895 3.18 0.44 NM_153168 2.31 0.37 NM_001037750 2.23 0.46

SUPPLEMENTAL TABLE S17: Genes Demonstrating Increased Repressive DimethylK9/K27-H3 Methylation in Resilient Animals Compared to Susceptible Animals (p<0.001)

Defeat Fold Resiliency Fold Accession Number Symbol Name Change Change NM_026894 1500001M20Rik RIKEN cDNA 1500001M20 gene 0.60 1.37 NM_029714 1700067C01Rik RIKEN cDNA 1700067C01 gene 0.65 1.45

209 NM_172919 2210010B09Rik RIKEN cDNA 2210010B09 gene 0.67 1.56 NM_175393 4930555G01Rik RIKEN cDNA 4930555G01 gene 0.73 1.38 NM_026377 6330577E15Rik RIKEN cDNA 6330577E15 gene 0.73 1.38 ATP-binding cassette, sub-family G (WHITE), member NM_009593 Abcg1 1 0.56 1.56 NM_145444 Acot5 Acyl-CoA thioesterase 5 0.69 1.37 NM_175086 Agtr1b Angiotensin II receptor, type 1b 0.61 1.49 NM_001033966 Ak2 Adenylate kinase 2 0.72 1.57 NM_031185 Akap12 A kinase (PRKA) anchor protein (gravin) 12 0.70 1.44 NM_170729 Ank3 Ankyrin 3, epithelial 0.71 1.39 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene 0.54 1.42 NM_145577 BC023179 CDNA sequence BC023179 0.70 1.51 NM_199150 BC049730 CDNA sequence BC049730 0.62 1.38 NM_026602 Bcas2 Breast carcinoma amplified sequence 2 0.59 1.47 Bone gamma-carboxyglutamate protein, related NM_031368 Bglap-rs1 sequence 1 0.58 1.51 NM_009765 Brca2 Breast cancer 2 0.70 1.47 NM_178245 Bsx Brain specific homeobox 0.69 1.45 NM_026862 Cd177 CD177 antigen 0.63 1.55 NM_027839 Ceacam20 CEA-related cell adhesion molecule 20 0.66 1.44 NM_009904 Clgn Calmegin 0.71 1.45 NM_026949 Cnot8 CCR4-NOT transcription complex, subunit 8 0.62 1.62 NM_007727 Cntn1 Contactin 1 0.71 1.46 NM_001011707 Cyp2c66 Cytochrome P450, family 2, subfamily c, polypeptide 66 0.60 1.38 NM_027030 Dcps Decapping enzyme, scavenger 0.71 1.43 NM_001004364 Ddef2 Development and differentiation enhancing factor 2 0.66 1.67 NM_010043 Des Desmin 0.72 1.42 NM_153743 Dnmt3a DNA methyltransferase 3A 0.65 1.45 NM_001009947 Dock11 Dedicator of cytokinesis 11 0.68 1.72 NM_026767 Dpm3 Dolichyl-phosphate mannosyltransferase polypeptide 3 0.73 1.42 NM_177890 EG233164 Predicted gene, EG233164 0.67 1.55 NM_001034869 EG245263 Predicted gene, EG245263 0.50 1.39 NM_198666 ENSMUSG00000033219 Predicted gene, ENSMUSG00000033219 0.72 1.48 NM_025513 Exosc3 Exosome component 3 0.67 1.38 NM_028066 F11 Coagulation factor XI 0.57 1.50 NM_001037997 Fert2 Fer (fms/fps related) protein kinase, testis specific 2 0.63 1.37 NM_008019 Fkbp1a FK506 binding protein 1a 0.52 1.44 NM_013523 Fshr Follicle stimulating hormone receptor 0.70 1.45 NM_178930 Gbf1 Golgi-specific brefeldin A-resistance factor 1 0.72 1.36 NM_028900 Gcc1 Golgi coiled coil 1 0.73 1.38 Glucosaminyl (N-acetyl) transferase 2, I-branching NM_133219 Gcnt2 enzyme 0.71 1.38 NM_001005425 Gm1008 Gene model 1008, (NCBI) 0.68 1.39 NM_001033417 Gm766 Gene model 766, (NCBI) 0.66 1.38 NM_145546 Gtf2b General transcription factor IIB 0.72 1.38 NM_010417 Heph Hephaestin 0.61 1.69 NM_198090 Hnrpa3 Heterogeneous nuclear ribonucleoprotein A3 0.71 1.63 NM_198030 Hsd17b13 Hydroxysteroid (17-beta) dehydrogenase 13 0.59 1.38 NM_008372 Il7r Interleukin 7 receptor 0.67 1.38 NM_008401 Itgam Integrin alpha M 0.64 1.42 NM_182782 Klhl25 Kelch-like 25 (Drosophila) 0.72 1.38 NM_001037918 Lipt1 Lipoyltransferase 1 0.70 1.45 NM_008866 Lypla1 Lysophospholipase 1 0.54 1.56 NM_008696 Map4k4 Mitogen-activated protein kinase kinase kinase kinase 4 0.69 1.62 NM_134012 Mbtd1 Mbt domain containing 1 0.57 1.38 Myeloid/lymphoid or mixed lineage-leukemia NM_022328 Mllt1 translocation to 1 homolog (Drosophila) 0.71 1.47 NM_028950 Nsun6 NOL1/NOP2/Sun domain family 6 0.71 1.40 NM_147016 Olfr1049 Olfactory receptor 1049 0.73 1.39 NM_001011735 Olfr1066 Olfactory receptor 1066 0.51 1.69 NM_146406 Olfr1076 Olfactory receptor 1076 0.69 1.58 NM_146849 Olfr1157 Olfactory receptor 1157 0.60 1.46 NM_001011804 Olfr1211 Olfactory receptor 1211 0.66 1.39 NM_146485 Olfr183 Olfactory receptor 183 0.73 1.48

210 NM_001011810 Olfr485 Olfactory receptor 485 0.67 1.49 NM_146498 Olfr490 Olfactory receptor 490 0.71 1.40 NM_001011858 Olfr504 Olfactory receptor 504 0.73 1.38 NM_146728 Olfr781 Olfactory receptor 781 0.61 1.42 NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.64 1.41 NM_001013580 Pard3 Par-3 (partitioning defective 3) homolog (C. elegans) 0.68 1.38 NM_025396 Pgls 6-phosphogluconolactonase 0.64 1.48 NM_029404 Phf14 PHD finger protein 14 0.65 1.37 NM_029406 Pih1d1 PIH1 domain containing 1 0.68 1.47 NM_008848 Pira6 Paired-Ig-like receptor A6 0.59 1.37 NM_026329 Polr2g Polymerase (RNA) II (DNA directed) polypeptide G 0.71 1.43 NM_011120 Prl7d1 Prolactin family 7, subfamily d, member 1 0.67 1.39 NM_054060 Psg25 Pregnancy-specific glycoprotein 25 0.73 1.61 NM_009005 Rab7 RAB7, member RAS oncogene family 0.66 1.74 NM_012025 Racgap1 Rac GTPase-activating protein 1 0.71 1.59 NM_009048 Reps1 RalBP1 associated Eps domain containing protein 0.72 1.39 NM_020509 Retnla Resistin like alpha 0.55 1.41 NM_011268 Rgs9 Regulator of G-protein signaling 9 0.67 1.53 NM_025934 Riok2 RIO kinase 2 (yeast) 0.52 1.48 NM_153503 Rnf113a1 Ring finger protein 113A1 0.67 1.41 NM_017475 Rragc Ras-related GTP binding C 0.57 1.46 NM_001013769 Rsl1 Regulator of sex limited protein 1 0.73 1.45 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) NM_172490 Sepsecs tRNA synthase 0.70 1.67 NM_012009 Sh2d1b1 SH2 domain protein 1B1 0.56 1.41 Solute carrier family 7 (cationic amino acid transporter, NM_177802 Slc7a15 y+ system), member 15 0.59 1.42 NM_009221 Snca Synuclein, alpha 0.70 1.36 NM_021336 Snrpa1 Small nuclear ribonucleoprotein polypeptide A' 0.73 1.60 Spermatogenesis associated glutamate (E)-rich protein NM_028561 Speer4b 4b 0.64 1.45 Spermatogenesis associated glutamate (E)-rich protein NM_025759 Speer4d 4d 0.66 1.63 Spastic paraplegia 20, spartin (Troyer syndrome) NM_144895 Spg20 homolog (human) 0.59 1.77 NM_011469 Sprr2b Small proline-rich protein 2B 0.72 1.70 NM_009273 Srp14 Signal recognition particle 14 0.66 1.52 NM_199319 Ssxb5 Synovial sarcoma, X member B, breakpoint 5 0.73 1.41 NM_173869 Stfa2l1 Stefin A2 like 1 0.68 1.55 NM_001010827 Taar7b Trace amine-associated receptor 7B 0.61 1.39 TAF3 RNA polymerase II, TATA box binding protein NM_027748 Taf3 (TBP)-associated factor 0.65 1.71 NM_001001297 Thnsl1 Threonine synthase-like 1 (bacterial) 0.60 1.36 NM_027495 Tmem144 Transmembrane protein 144 0.62 1.46 NM_011640 Trp53 Transformation related protein 53 0.69 1.42 NM_030254 Tusc3 Tumor suppressor candidate 3 0.67 1.46 NM_201641 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.72 1.39 NM_024258 Usp16 Ubiquitin specific peptidase 16 0.71 1.43 NM_134182 V1rc27 Vomeronasal 1 receptor, C27 0.68 1.37 NM_206869 V1rd16 Vomeronasal 1 receptor, D16 0.55 1.40 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 0.59 1.52 NM_207618 V1rd18 Vomeronasal 1 receptor, D18 0.62 1.57 NM_207546 V1rd20 Vomeronasal 1 receptor, D20 0.53 1.47 NM_134202 V1rf5 Vomeronasal 1 receptor, F5 0.73 1.38 NM_134243 V1rh20 Vomeronasal 1 receptor, H20 0.70 1.45 NM_134215 V1rh6 Vomeronasal 1 receptor, H6 0.58 1.43 NM_134223 V1ri6 Vomeronasal 1 receptor, I6 0.72 1.37 NM_009487 V2r10 Vomeronasal 2, receptor, 10 0.67 1.44 Williams-Beuren syndrome chromosome region 18 NM_025362 Wbscr18 homolog (human) 0.73 1.60 NM_001012704 Wfdc13 WAP four-disulfide core domain 13 0.61 1.37 NM_173364 Zfp445 Zinc finger protein 445 0.67 1.71 NM_177622 Zfp595 Zin finger protein 595 0.54 1.45 NM_027820 0.71 1.38 NM_134211 0.66 1.67

211 NM_001002780 0.57 1.48 NM_029813 0.71 1.52 NM_001024849 0.73 1.53 NM_020295 0.65 1.48

SUPPLEMENTAL TABLE S18: Genes Demonstrating Decreased Repressive DimethylK9/K27-H3 Methylation in Resilient Animals Compared to Susceptible Animals (p<0.001)

Defeat Fold Resiliency Fold Accession Number Symbol Name Change Change NM_026503 1110058L19Rik RIKEN cDNA 1110058L19 gene 1.51 0.70 NM_053102 15-Sep Selenoprotein 1.52 0.53 NM_026469 1700025D03Rik RIKEN cDNA 1700025D03 gene 1.55 0.68 NM_029335 1700026D08Rik RIKEN cDNA 1700026D08 gene 1.60 0.63 NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene 1.63 0.69 NM_026627 1700113O17Rik RIKEN cDNA 1700113O17 gene 1.43 0.65 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 1.55 0.65 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 1.58 0.62 NM_027087 2300006N05Rik RIKEN cDNA 2300006N05 gene 1.42 0.70 NM_027093 2310003L22Rik RIKEN cDNA 2310003L22 gene 1.54 0.65 NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene 1.68 0.71 NM_027426 2610109H07Rik RIKEN cDNA 2610109H07 gene 1.50 0.64 NM_026010 2610209A20Rik RIKEN cDNA 2610209A20 gene 1.64 0.49 NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene 1.47 0.60 NM_001040397 4631422O05Rik RIKEN cDNA 4631422O05 gene 1.57 0.71 NM_172652 4632411B12Rik RIKEN cDNA 4632411B12 gene 1.47 0.71 NM_175497 4732495G21Rik RIKEN cDNA 4732495G21 gene 1.46 0.67 NM_001025373 4930432O21Rik RIKEN cDNA 4930432O21 gene 1.68 0.70 NM_172450 4930539E08Rik RIKEN cDNA 4930539E08 gene 1.45 0.65 NM_183111 4930563M21Rik RIKEN cDNA 4930563M21 gene 1.55 0.58 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 1.43 0.68 NM_172534 4932411E22Rik RIKEN cDNA 4932411E22 gene 1.42 0.63 NM_175368 4933402P03Rik RIKEN cDNA 4933402P03 gene 1.57 0.66 NM_177880 4933411G11Rik RIKEN cDNA 4933411G11Rik gene 1.52 0.62 NM_027789 5430416O09Rik RIKEN cDNA 5430416O09 gene 1.55 0.66 NM_010667 5430421N21Rik RIKEN cDNA 5430421N21 gene 1.57 0.70 NM_178243 5830403L16Rik RIKEN cDNA 5830403L16 gene 1.58 0.66 NM_001033776 7420416P09Rik RIKEN cDNA 7420416P09 gene 1.54 0.71 NM_026566 9430023L20Rik RIKEN cDNA 9430023L20 gene 1.43 0.71 NM_176943 9630028B13Rik RIKEN cDNA 9630028B13 gene 1.45 0.70 NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene 1.94 0.71 NM_183194 9930109F21Rik RIKEN cDNA 9930109F21 gene 1.41 0.60 NM_020591 A030009H04Rik RIKEN cDNA A030009H04 gene 1.66 0.70 Alpha 1,3-galactosyltransferase 2 NM_001009819 A3galt2 (isoglobotriaosylceramide synthase) 1.63 0.60 NM_178767 A530016O06Rik RIKEN cDNA A530016O06 gene 1.49 0.69 NM_177248 A630005I04Rik RIKEN cDNA A630005I04 gene 1.42 0.70 NM_175449 A630077B13Rik RIKEN cDNA A630077B13 gene 1.46 0.71 NM_008992 Abcd4 ATP-binding cassette, sub-family D (ALD), member 4 1.51 0.65 ABO blood group (transferase A, alpha 1-3-N- acetylgalactosaminyltransferase, transferase B, alpha 1- NM_030718 Abo 3-galactosyltransferase) 1.56 0.64 NM_178308 Abpg Androgen binding protein gamma 1.57 0.69 NM_025271 Actl7b Actin-like 7b 1.77 0.67 NM_033268 Actn2 Actinin alpha 2 1.51 0.67 NM_019655 Adar Adenosine deaminase, RNA-specific 1.56 0.67 NM_133883 Adprhl2 ADP-ribosylhydrolase like 2 1.65 0.71 AHA1, activator of heat shock protein ATPase homolog NM_172391 Ahsa2 2 (yeast) 2.15 0.48 NM_177869 AI847670 Expressed sequence AI847670 1.46 0.67 NM_177912 AI987692 Expressed sequence AI987692 1.49 0.63 NM_009654 Alb Albumin 1.55 0.64 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 1.44 0.68

212 Anillin, actin binding protein (scraps homolog, NM_028390 Anln Drosophila) 1.47 0.65 NM_008486 Anpep Alanyl (membrane) aminopeptidase 1.46 0.70 NM_172808 Antxrl Anthrax toxin receptor-like 1.57 0.63 NM_030255 Apobec3 Apolipoprotein B editing complex 3 1.60 0.60 NM_133996 Apon Apolipoprotein N 1.49 0.71 NM_175087 Aqp6 Aquaporin 6 1.49 0.59 NM_029270 Arhgap24 Rho GTPase activating protein 24 1.56 0.71 NM_177566 Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 1.46 0.71 NM_024191 Arl2bp ADP-ribosylation factor-like 2 binding protein 1.47 0.71 NM_026034 Armc10 Armadillo repeat containing 10 1.41 0.61 N-acylsphingosine amidohydrolase (alkaline NM_175731 Asah3 ceramidase) 3 1.58 0.70 NM_018731 Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 1.45 0.67 NM_134157 Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 1.45 0.57 NM_020572 Aurkc Aurora kinase C 1.45 0.64 NM_028844 Aven Apoptosis, caspase activation inhibitor 1.69 0.56 NM_199313 AY053573 CDNA sequence AY053573 1.53 0.70 NM_001018019 AY616753 CDNA sequence, AY616753 1.70 0.68 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, NM_020283 B3galt1 polypeptide 1 1.64 0.64 NM_144832 BC017643 CDNA sequence BC017643 1.77 0.67 NM_001008549 BC043301 CDNA sequence BC043301 1.68 0.62 NM_175020 BC048599 CDNA sequence BC048599 1.56 0.65 NM_198667 BC061212 CDNA sequence BC061212 1.42 0.65 NM_010871 Birc1f Baculoviral IAP repeat-containing 1f 1.44 0.67 NM_008528 Blnk B-cell linker 1.42 0.61 NM_001037719 Btla B and T lymphocyte associated 1.55 0.58 NM_020558 C1d Nuclear DNA binding protein 1.49 0.70 NM_016704 C6 Complement component 6 1.50 0.61 NM_011274 C80913 Expressed sequence C80913 1.68 0.66 NM_146148 C8a Complement component 8, alpha polypeptide 1.45 0.71 NM_178721 Cadm2 Cell adhesion molecule 2 1.49 0.64 NM_007605 Capza3 Capping protein (actin filament) muscle Z-line, alpha 3 1.46 0.71 NM_009802 Car6 Carbonic anhydrase 6 1.55 0.64 NM_175362 Card11 Caspase recruitment domain family, member 11 1.65 0.58 NM_009810 Casp3 Caspase 3 1.76 0.66 NM_007609 Casp4 Caspase 4, apoptosis-related cysteine peptidase 1.51 0.66 NM_001012309 Ccdc55 Coiled-coil domain containing 55 1.42 0.55 NM_201372 Ccdc84 Coiled-coil domain containing 84 1.52 0.64 NM_207268 Ccdc87 Coiled-coil domain containing 87 1.67 0.65 NM_001013412 Ccl26l Chemokine (C-C motif) ligand 26-like 1.49 0.67 NM_172909 Cd163l1 CD163 molecule-like 1 1.48 0.71 NM_007639 Cd1d1 CD1d1 antigen 1.43 0.70 NM_007652 Cd59a CD59a antigen 1.61 0.64 NM_009855 Cd80 CD80 antigen 1.45 0.70 NM_025496 Cdrt4 CMT1A duplicated region transcript 4 1.76 0.57 NM_177150 Cenpt Centromere protein T 1.62 0.60 NM_021439 Chst11 Carbohydrate sulfotransferase 11 1.44 0.68 NM_016803 Chst3 Carbohydrate (chondroitin 6/keratan) sulfotransferase 3 1.45 0.68 NM_009899 Clca1 Chloride channel calcium activated 1 1.44 0.64 NM_139148 Clca4 Chloride channel calcium activated 4 1.61 0.62 NM_001007223 Clec3a C-type lectin domain family 3, member a 1.56 0.61 NM_172732 Clec9a C-type lectin domain family 9, member a 1.44 0.71 NM_011802 Clpx Caseinolytic peptidase X (E.coli) 1.42 0.68 CKLF-like MARVEL transmembrane domain NM_153582 Cmtm4 containing 4 1.48 0.70 NM_001037865 Col28a1 Collagen, type XXVIII, alpha 1 1.48 0.61 NM_178893 Coro2a Coronin, actin binding protein 2A 1.45 0.70 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 1.75 0.63 NM_001039049 Cox8c Cytochrome c oxidase, subunit VIIIc 1.71 0.62 NM_018867 Cpxm2 Carboxypeptidase X 2 (M14 family) 1.54 0.67 NM_009965 Cryba1 Crystallin, beta A1 1.66 0.63 NM_153076 Crygn Crystallin, gamma N 1.47 0.67

213 NM_027874 Csnk1d Casein kinase 1, delta 1.57 0.70 NM_007792 Csrp2 Cysteine and glycine-rich protein 2 1.51 0.65 NM_029787 Cyb5r3 Cytochrome b5 reductase 3 1.58 0.69 NM_009999 Cyp2b10 Cytochrome P450, family 2, subfamily b, polypeptide 10 1.52 0.71 NM_016890 Dctn3 Dynactin 3 1.56 0.61 NM_016672 Ddc Dopa decarboxylase 1.60 0.64 NM_145157 Defb19 Defensin beta 19 1.52 0.60 NM_018769 Dfna5h Deafness, autosomal dominant 5 homolog (human) 1.46 0.71 NM_001024474 Diras2 DIRAS family, GTP-binding RAS-like 2 1.54 0.65 NM_007769 Dmbt1 Deleted in malignant brain tumors 1 1.47 0.71 NM_007870 Dnase1l3 Deoxyribonuclease 1-like 3 1.46 0.63 NM_019957 Dnase2b Deoxyribonuclease II beta 1.41 0.64 NM_176913 Dpep2 Dipeptidase 2 1.55 0.71 NM_013504 Dsc1 Desmocollin 1 1.54 0.65 NM_007888 Dvl2 Dishevelled 2, dsh homolog (Drosophila) 1.45 0.69 NM_009342 Dynlt1 Dynein light chain Tctex-type 1 1.51 0.59 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 1.70 0.59 NM_139293 Ece2 Endothelin converting enzyme 2 1.47 0.66 NM_007904 Ednrb Endothelin receptor type B 1.47 0.68 NM_177593 EG210155 Predicted gene, EG210155 1.41 0.69 NM_177665 EG229862 Predicted gene, EG229862 1.63 0.52 NM_177890 EG233164 Predicted gene, EG233164 1.55 0.69 NM_183320 EG331529 Predicted gene, EG331529 1.49 0.70 NM_198657 EG381438 Predicted gene, EG381438 1.82 0.68 NM_001004162 EG432436 Predicted gene, EG432436 1.47 0.65 NM_001034893 EG435970 Predicted gene, EG435970 1.42 0.62 NM_001037931 EG628416 Predicted gene, EG628416 1.43 0.66 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) 1.43 0.63 Engulfment and cell motility 1, ced-12 homolog (C. NM_080288 Elmo1 elegans) 1.71 0.66 Engulfment and cell motility 2, ced-12 homolog (C. NM_080287 Elmo2 elegans) 1.47 0.68 NM_016885 Emcn Endomucin 1.54 0.71 NM_145506 Epb4.1l5 Erythrocyte protein band 4.1-like 5 1.59 0.51 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide 1.50 0.70 NM_016857 Exoc7 Exocyst complex component 7 1.42 0.70 NM_025923 Fancl Fanconi anemia, complementation group L 1.45 0.71 NM_001033669 Fbxw10 F-box and WD-40 domain protein 10 1.61 0.68 NM_175401 Fbxw17 F-box and WD-40 domain protein 17 1.45 0.67 NM_010190 Fcnb Ficolin B 1.59 0.70 NM_001029984 Fcrlb Fc receptor-like B 1.65 0.69 NM_015759 Fgd3 FYVE, RhoGEF and PH domain containing 3 1.51 0.63 NM_010197 Fgf1 Fibroblast growth factor 1 1.64 0.53 NM_019873 Fkbpl FK506 binding protein-like 1.54 0.70 NM_008239 Foxq1 Forkhead box Q1 1.48 0.63 NM_018771 Gipc1 GIPC PDZ domain containing family, member 1 1.46 0.64 NM_008120 Gja4 Gap junction membrane channel protein alpha 4 1.43 0.69 NM_008123 Gja8 Gap junction membrane channel protein alpha 8 1.47 0.57 NM_010291 Gjb5 Gap junction membrane channel protein beta 5 1.55 0.71 NM_019832 Gkap1 G kinase anchoring protein 1 1.44 0.61 NM_025467 Gkn2 Gastrokine 2 1.45 0.69 NM_145935 Glyat Glycine-N-acyltransferase 1.73 0.68 NM_001033473 Gm1157 Gene model 1157, (NCBI) 1.50 0.66 NM_001018031 Gm414 Gene model 414, (NCBI) 2.03 0.66 NM_001013751 Gm52 Gene model 52, (NCBI) 1.53 0.70 NM_001033252 Gm732 Gene model 732, (NCBI) 1.58 0.55 NM_025989 Gp2 Glycoprotein 2 (zymogen granule membrane) 1.80 0.53 NM_133776 Gpr110 G protein-coupled receptor 110 1.62 0.70 NM_001033493 Gpr111 G protein-coupled receptor 111 1.61 0.70 NM_008159 Gpr33 G protein-coupled receptor 33 1.52 0.71 NM_010343 Gpx5 Glutathione peroxidase 5 1.49 0.66 NM_001033498 Gramd2 GRAM domain containing 2 1.48 0.65 NM_008175 Grn Granulin 1.42 0.67 NM_025768 Grtp1 GH regulated TBC protein 1 1.48 0.69

214 NM_026764 Gstm4 Glutathione S-transferase, mu 4 1.55 0.68 NM_023630 Gtf2a1l General transcription factor IIA, 1-like 1.44 0.71 NM_008193 Guk1 Guanylate kinase 1 1.55 0.69 NM_207105 H2-Ab1 Histocompatibility 2, class II antigen A, beta 1 1.50 0.66 NM_177635 H2-M11 Histocompatibility 2, M region locus 11 1.50 0.67 NM_207225 Hdac4 Histone deacetylase 4 1.65 0.70 NM_013547 Hgd Homogentisate 1, 2-dioxygenase 1.65 0.61 NM_018792 Hils1 Histone H1-like protein in spermatids 1 1.46 0.71 NM_008309 Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 1.43 0.69 NM_010491 Iapp Islet amyloid polypeptide 1.46 0.60 Intercellular adhesion molecule 4, Landsteiner-Wiener NM_023892 Icam4 blood group 1.48 0.61 NM_133871 Ifi44 Interferon-induced protein 44 1.47 0.58 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 1.46 0.66 NM_010549 Il11ra1 Interleukin 11 receptor, alpha chain 1 1.47 0.55 NM_008355 Il13 Interleukin 13 1.47 0.66 NM_010551 Il16 Interleukin 16 1.57 0.71 NM_019450 Il1f6 Interleukin 1 family, member 6 1.49 0.69 NM_008362 Il1r1 Interleukin 1 receptor, type I 1.57 0.69 NM_010555 Il1r2 Interleukin 1 receptor, type II 1.55 0.66 NM_008364 Il1rap Interleukin 1 receptor accessory protein 1.48 0.69 NM_001005784 Inadl InaD-like (Drosophila) 1.50 0.61 NM_008386 Ins1 Insulin I 1.58 0.65 NM_001029872 Itgad Integrin, alpha D 1.54 0.59 NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 1.59 0.69 NM_173001 Jmjd1a Jumonji domain containing 1A 1.53 0.66 NM_030887 Jundm2 Jun dimerization protein 2 1.45 0.68 NM_010594 Kap Kidney androgen regulated protein 1.47 0.70 Potassium voltage-gated channel, subfamily H (eag- NM_001031811 Kcnh8 related), member 8 1.44 0.62 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 1.52 0.67 NM_010615 Kif11 Kinesin family member 11 1.43 0.70 NM_178771 Klhl26 Kelch-like 26 (Drosophila) 1.52 0.69 NM_174865 Klk15 Kallikrein related-peptidase 15 1.79 0.59 NM_010644 Klk1b26 Kallikrein 1-related petidase b26 1.45 0.71 Kallikrein related-peptidase 4 (prostase, enamel matrix, NM_019928 Klk4 prostate) 1.94 0.68 NM_010653 Klrc2 Killer cell lectin-like receptor subfamily C, member 2 1.49 0.66 NM_010654 Klrd1 Killer cell lectin-like receptor, subfamily D, member 1 1.42 0.67 NM_001039124 Kncn Kinocilin 1.65 0.62 NM_010665 Krt32 Keratin 32 1.70 0.62 NM_027563 Krt34 Keratin 34 1.44 0.62 NM_008475 Krt4 Keratin 4 1.48 0.67 NM_019956 Krt71 Keratin 71 1.42 0.66 NM_130870 Krtap16-1 Keratin associated protein 16-1 1.62 0.65 NM_138593 Larp7 La ribonucleoprotein domain family, member 7 1.56 0.64 NM_025420 Lce1m Late cornified envelope 1M 1.50 0.67 NM_145835 Lctl Lactase-like 1.55 0.57 NM_010710 Lhx2 LIM homeobox protein 2 1.42 0.65 NM_008280 Lipc Lipase, hepatic 1.54 0.64 NM_001040089 LOC621852 Similar to similar to testis expressed homeobox 2 1.59 0.68 NM_029796 Lrg1 Leucine-rich alpha-2-glycoprotein 1 1.54 0.67 NM_013588 Lrrc23 Leucine rich repeat containing 23 1.43 0.69 NM_010745 Ly86 Lymphocyte antigen 86 1.57 0.69 NM_017372 Lyzs Lysozyme 1.44 0.69 NM_001013802 Macrod2 MACRO domain containing 2 1.55 0.66 NM_020015 Magea1 Melanoma antigen, family A, 1 1.55 0.64 NM_020017 Magea3 Melanoma antigen, family A, 3 1.68 0.63 Membrane associated guanylate kinase, WW and PDZ NM_015823 Magi2 domain containing 2 1.46 0.71 NM_016896 Map3k14 Mitogen-activated protein kinase kinase kinase 14 1.43 0.69 NM_010775 Mbl1 Mannose binding lectin (A) 1.59 0.52 Mediator of RNA polymerase II transcription, subunit 11 NM_025397 Med11 homolog (S. cerevisiae) 1.45 0.71

215 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 1.59 0.51 NM_010798 Mif Macrophage migration inhibitory factor 1.44 0.67 NM_026178 Mmd Monocyte to macrophage differentiation-associated 1.59 0.67 NM_175217 Mmd2 Monocyte to macrophage differentiation-associated 2 1.49 0.65 NM_008607 Mmp13 Matrix metallopeptidase 13 1.56 0.66 NM_152944 Mmp21 Matrix metallopeptidase 21 1.50 0.69 NM_001033450 Mnda Myeloid cell nuclear differentiation antigen 1.53 0.64 NM_139296 Moxd2 Monooxygenase, DBH-like 2 1.51 0.69 NM_172610 Mpped1 Metallophosphoesterase domain containing 1 1.79 0.68 NM_010827 Msc Musculin 1.46 0.69 NM_028860 Mtmr3 Myotubularin related protein 3 1.41 0.69 NM_008669 Naga N-acetyl galactosaminidase, alpha 1.50 0.64 NM_133762 Ncapg2 Non-SMC condensin II complex, subunit G2 1.50 0.68 NADH dehydrogenase (ubiquinone) 1, alpha/beta NM_028177 Ndufab1 subcomplex, 1 1.49 0.71 NM_010887 Ndufs4 NADH dehydrogenase (ubiquinone) Fe-S protein 4 1.57 0.60 Neural precursor cell expressed, developmentally down- NM_008682 Nedd1 regulated gene 1 1.57 0.65 Neural precursor cell expressed, developmentally down- NM_017464 Nedd9 regulated gene 9 1.41 0.68 NIMA (never in mitosis gene a)-related expressed kinase NM_011848 Nek3 3 1.54 0.70 NM_031375 Ngrn Neugrin, neurite outgrowth associated 1.63 0.69 NM_016718 Ninj2 Ninjurin 2 1.47 0.67 NM_080637 Nme5 Expressed in non-metastatic cells 5 1.43 0.62 NM_207242 Npc1l1 NPC1-like 1 1.76 0.55 NM_008722 Npm1 Nucleophosmin 1 1.49 0.66 Nudix (nucleoside diphosphate linked moiety X)-type NM_026497 Nudt12 motif 12 1.73 0.63 NM_010949 Numb Numb gene homolog (Drosophila) 1.71 0.57 NM_008750 Nxn Nucleoredoxin 1.48 0.64 NM_146762 Olfr1013 Olfactory receptor 1013 1.52 0.55 NM_146586 Olfr1018 Olfactory receptor 1018 1.49 0.64 NM_146843 Olfr1097 Olfactory receptor 1097 1.55 0.71 NM_001005227 Olfr1200 Olfactory receptor 1200 1.64 0.71 NM_146985 Olfr1270 Olfactory receptor 1270 1.68 0.69 NM_146793 Olfr1271 Olfactory receptor 1271 1.49 0.68 NM_146852 Olfr1339 Olfactory receptor 1339 1.46 0.71 NM_001011853 Olfr1425 Olfactory receptor 1425 1.80 0.66 NM_013728 Olfr154 Olfactory receptor 154 1.48 0.68 NM_147068 Olfr166 Olfactory receptor 166 1.55 0.67 NM_146994 Olfr201 Olfactory receptor 201 1.45 0.71 NM_146446 Olfr215 Olfactory receptor 215 1.52 0.65 NM_146429 Olfr223 Olfactory receptor 223 1.42 0.57 NM_146625 Olfr355 Olfactory receptor 355 1.48 0.68 NM_146622 Olfr360 Olfactory receptor 360 1.63 0.64 NM_146270 Olfr370 Olfactory receptor 370 1.47 0.71 NM_147023 Olfr385 Olfactory receptor 385 1.54 0.62 NM_146710 Olfr398 Olfactory receptor 398 1.64 0.67 NM_146721 Olfr424 Olfactory receptor 424 1.63 0.68 NM_146711 Olfr43 Olfactory receptor 43 1.57 0.62 NM_147064 Olfr449 Olfactory receptor 449 1.42 0.69 NM_001011528 Olfr456 Olfactory receptor 456 1.48 0.71 NM_001011776 Olfr527 Olfactory receptor 527 1.60 0.66 NM_001011815 Olfr533 Olfactory receptor 533 1.65 0.67 NM_146520 Olfr536 Olfactory receptor 536 1.53 0.68 NM_147041 Olfr57 Olfactory receptor 57 1.41 0.63 NM_146360 Olfr574 Olfactory receptor 574 1.76 0.64 NM_146315 Olfr62 Olfactory receptor 62 1.55 0.70 NM_147119 Olfr632 Olfactory receptor 632 1.45 0.69 NM_146820 Olfr655 Olfactory receptor 655 1.81 0.71 NM_147059 Olfr668 Olfactory receptor 668 1.44 0.70 NM_146355 Olfr692 Olfactory receptor 692 1.48 0.56 NM_207008 Olfr773-ps1 Olfactory receptor 773, pseudogene 1 1.52 0.70

216 NM_146729 Olfr784 Olfactory receptor 784 1.41 0.67 NM_146931 Olfr796 Olfactory receptor 796 1.74 0.59 NM_146330 Olfr958 Olfactory receptor 958 1.49 0.70 NM_146828 Olfr975 Olfactory receptor 975 1.74 0.61 NM_146367 Olfr976 Olfactory receptor 976 1.49 0.64 NM_201258 Oog3 Oogenesin 3 1.46 0.71 NM_001013759 OTTMUSG00000000934 Predicted gene, OTTMUSG00000000934 1.47 0.67 NM_001007584 OTTMUSG00000002038 Predicted gene, OTTMUSG00000002038 1.53 0.71 NM_001025574 OTTMUSG00000015915 Predicted gene, OTTMUSG00000015915 1.53 0.66 NM_007696 Ovgp1 Oviductal glycoprotein 1 1.44 0.70 NM_001001490 Oxgr1 Oxoglutarate (alpha-ketoglutarate) receptor 1 1.65 0.68 Phosphoprotein associated with glycosphingolipid NM_053182 Pag1 microdomains 1 1.42 0.70 NM_011044 Pck1 Phosphoenolpyruvate carboxykinase 1, cytosolic 1.56 0.64 NM_008791 Pcp4 Purkinje cell protein 4 1.46 0.65 NM_008797 Pcx Pyruvate carboxylase 1.44 0.56 Phosphodiesterase 6C, cGMP specific, cone, alpha NM_033614 Pde6c prime 1.51 0.69 NM_008811 Pdha2 Pyruvate dehydrogenase E1 alpha 2 1.56 0.44 NM_008819 Pemt Phosphatidylethanolamine N-methyltransferase 1.49 0.69 NM_053191 Pi15 Peptidase inhibitor 15 1.60 0.70 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 1.45 0.67 NM_029686 Pkd1l2 Polycystic kidney disease 1 like 2 1.43 0.70 NM_011107 Pla2g1b Phospholipase A2, group IB, pancreas 1.50 0.71 NM_008867 Pla2r1 Phospholipase A2 receptor 1 1.44 0.69 NM_148937 Plcd4 Phospholipase C, delta 4 1.57 0.62 Pleckstrin homology domain containing, family A NM_133942 Plekha1 (phosphoinositide binding specific) member 1 1.42 0.70 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 1.64 0.57 NM_027504 Prdm16 PR domain containing 16 1.49 0.61 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 1.56 0.61 NM_008865 Prl3b1 Prolactin family 3, subfamily b, member 1 1.44 0.65 NM_008936 Prop1 Paired like homeodomain factor 1 1.76 0.62 NM_028447 Prrc1 Proline-rich coiled-coil 1 1.57 0.61 NM_009430 Prss2 Protease, serine, 2 1.81 0.69 NM_133351 Prss8 Protease, serine, 8 (prostasin) 1.56 0.60 NM_028195 Pscd4 Pleckstrin homology, Sec7 and coiled/coil domains 4 1.61 0.70 NM_030723 Pum2 Pumilio 2 (Drosophila) 1.44 0.67 NM_011236 Rad52 RAD52 homolog (S. cerevisiae) 1.41 0.64 NM_023579 Ranbp5 RAN binding protein 5 1.43 0.71 NM_138580 Rdbp RD RNA-binding protein 1.56 0.68 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 1.56 0.64 NM_175372 Rdh13 Retinol dehydrogenase 13 (all-trans and 9-cis) 1.47 0.71 NM_021300 Rhox4b Reproductive homeobox 4B 1.75 0.66 NM_001039689 Rhox4c Reproductive homeobox 4C 1.62 0.67 NM_001039695 Rhox4d Reproductive homeobox 4D 1.60 0.64 NM_201236 Rhox4e Reproductive homeobox 4E 1.51 0.70 NM_001039696 Rhox4h Reproductive homeobox 4H 1.45 0.66 NM_172521 RP23-336F11.32 Nuclear protein in testis 1.74 0.61 NM_001002239 Rpl17 Ribosomal protein L17 1.56 0.70 NM_009081 Rpl28 Ribosomal protein L28 1.44 0.68 NM_026594 Rpl39l Ribosomal protein L39-like 1.48 0.62 NM_026467 Rps27l Ribosomal protein S27-like 1.56 0.70 NM_145373 Sectm1a Secreted and transmembrane 1A 1.53 0.71 NM_011347 Selp Selectin, platelet 1.62 0.62 NM_029100 Sepn1 Selenoprotein N, 1 1.47 0.66 Serine (or cysteine) peptidase inhibitor, clade A, NM_009247 Serpina1e member 1e 1.44 0.71 Serine (or cysteine) peptidase inhibitor, clade A, NM_026687 Serpina1f member 1f 1.61 0.70 NM_021372 Sertad2 SERTA domain containing 2 1.52 0.65 NM_144792 Sgms1 Sphingomyelin synthase 1 1.60 0.70 NM_019658 Shoc2 Soc-2 (suppressor of clear) homolog (C. elegans) 1.49 0.67

217 Sirtuin 2 (silent mating type information regulation 2, NM_022432 Sirt2 homolog) 2 (S. cerevisiae) 1.45 0.54 NM_177016 Slc17a4 Solute carrier family 17 (sodium phosphate), member 4 1.67 0.66 NM_177243 Slc26a9 Solute carrier family 26, member 9 1.60 0.67 NM_011392 Slc34a1 Solute carrier family 34 (sodium phosphate), member 1 1.77 0.61 Solute carrier family 35 (UDP-N-acetylglucosamine NM_144902 Slc35a3 (UDP-GlcNAc) transporter), member 3 1.71 0.66 NM_134060 Slc35b3 Solute carrier family 35, member B3 1.58 0.69 NM_001039676 Slc39a2 Solute carrier family 39 (zinc transporter), member 2 1.42 0.70 NM_011403 Slc4a1 Solute carrier family 4 (anion exchanger), member 1 1.41 0.58 Solute carrier organic anion transporter family, member NM_033314 Slco2a1 2a1 1.43 0.69 NM_211355 Smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 1.43 0.70 NM_007706 Socs2 Suppressor of cytokine signaling 2 1.41 0.70 NM_029599 Spag4l Sperm associated antigen 4-like 1.54 0.66 NM_019866 Spib Spi-B transcription factor (Spi-1/PU.1 related) 1.52 0.66 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 1.62 0.66 NM_183284 Spink2 Serine peptidase inhibitor, Kazal type 2 1.55 0.56 NM_009258 Spink3 Serine peptidase inhibitor, Kazal type 3 1.48 0.66 NM_011468 Sprr2a Small proline-rich protein 2A 1.70 0.66 NM_020611 Srd5a2l Steroid 5 alpha-reductase 2-like 1.52 0.69 Stress 70 protein chaperone, microsome-associated, NM_030201 Stch human homolog 1.76 0.59 NM_011494 Stk16 Serine/threonine kinase 16 1.44 0.66 NM_026474 Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 1.72 0.53 NM_023135 Sult1e1 Sulfotransferase family 1E, member 1 1.61 0.67 NM_053205 Taar1 Trace amine-associated receptor 1 1.56 0.63 NM_145968 Tagap T-cell activation Rho GTPase-activating protein 1.41 0.66 NM_207021 Tas2r117 Taste receptor, type 2, member 117 2.38 0.44 NM_199159 Tas2r135 Taste receptor, type 2, member 135 1.56 0.66 NM_013773 Tcl1b1 T-cell leukemia/lymphoma 1B, 1 1.49 0.67 NM_009363 Tff2 Trefoil factor 2 (spasmolytic protein 1) 1.70 0.60 NM_018783 Tfip11 Tuftelin interacting protein 11 1.44 0.70 NM_009375 Tg Thyroglobulin 1.52 0.71 NM_028799 Tgm5 Transglutaminase 5 1.44 0.62 NM_028597 Thoc3 THO complex 3 1.61 0.56 NM_146153 Thrap3 Thyroid hormone receptor associated protein 3 1.44 0.65 Translocase of inner mitochondrial membrane 10 NM_013899 Timm10 homolog (yeast) 1.42 0.64 NM_172476 Tmc7 Transmembrane channel-like gene family 7 1.47 0.68 NM_177735 Tmem130 Transmembrane protein 130 1.52 0.66 NM_153589 Tmem16b Transmembrane protein 16B 1.48 0.70 NM_178915 Tmem179 Transmembrane protein 179 1.43 0.70 NM_144805 Tmem40 Transmembrane protein 40 1.68 0.51 NM_025693 Tmem41a Transmembrane protein 41a 1.59 0.52 NM_001030297 Tmprss11c Transmembrane protease, serine 11c 1.48 0.71 Tumor necrosis factor receptor superfamily, member 14 NM_178931 Tnfrsf14 (herpesvirus entry mediator) 1.51 0.65 NM_009407 Tnp1 Transition protein 1 1.52 0.51 NM_031176 Tnxb Tenascin XB 1.55 0.62 NM_001024206 Trappc1 Trafficking protein particle complex 1 1.44 0.67 NM_001025599 Trim26 Tripartite motif protein 26 1.48 0.60 NM_011662 Tyrobp TYRO protein tyrosine kinase binding protein 1.47 0.71 NM_177823 Ubash3a Ubiquitin associated and SH3 domain containing, A 1.65 0.58 NM_145079 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 1.52 0.71 NM_053218 V1ra3 Vomeronasal 1 receptor, A3 1.57 0.68 NM_053221 V1ra6 Vomeronasal 1 receptor, A6 1.50 0.65 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 1.46 0.71 NM_011704 Vnn1 Vanin 1 1.53 0.66 NM_019780 Vps29 Vacuolar protein sorting 29 (S. pombe) 1.55 0.63 NM_138685 Wfdc15b WAP four-disulfide core domain 15B 1.45 0.70 NM_197940 Wipf2 WAS/WASL interacting protein family, member 2 1.44 0.54 NM_023784 Yipf7 Yip1 domain family, member 7 1.45 0.66 NM_018791 Zfp108 Zinc finger protein 108 1.47 0.68

218 NM_175428 Zfp295 Zinc finger protein 295 1.58 0.64 NM_199304 Zfp341 Zinc finger protein 341 1.62 0.63 NM_028913 Zfp819 Zinc finger protein 819 1.56 0.59 NM_001001130 Zfp85-rs1 Zinc finger protein 85, related sequence 1 1.66 0.67 NM_001033195 1.92 0.63 NM_001024470 1.78 0.67 NM_175330 1.42 0.71 NM_025766 1.53 0.67 NM_001013752 1.59 0.70 NM_026461 1.53 0.69 NM_001039148 1.46 0.68 NM_028045 1.46 0.70 NM_183120 1.43 0.64 NM_001001987 1.45 0.67 NM_183108 1.57 0.63 NM_001013781 1.68 0.70 NM_008835 1.42 0.62

SUPPLEMENTAL TABLE S19: Genes Demonstrating Increased Phospho-CREB Binding in Resilient Animals Compared to Susceptible Animals(p<0.001)

Defeat Fold Resiliency Fold Accession Number Symbol Name Change Change NM_017380 9-Sep Septin 9 0.25 3.16 NM_026714 0610037D15Rik RIKEN cDNA 0610037D15 gene 0.32 2.89 NM_024172 1500019G21Rik RIKEN cDNA 1500019G21 gene 0.30 3.34 NM_025956 1700011H14Rik RIKEN cDNA 1700011H14 gene 0.41 2.95 NM_021437 1700123O20Rik RIKEN cDNA 1700123O20 gene 0.27 2.70 NM_025464 1810021J13Rik RIKEN cDNA 1810021J13 gene 0.32 3.06 NM_178619 1810026J23Rik RIKEN cDNA 1810026J23 gene 0.35 2.96 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 0.42 2.62 NM_025591 2010309E21Rik RIKEN cDNA 2010309E21 gene 0.42 2.67 NM_027977 2310001A20Rik RIKEN cDNA 2310001A20 gene 0.34 2.73 NM_175107 2310022A10Rik RIKEN cDNA 2310022A10 gene 0.26 2.74 NM_026511 2810002N01Rik RIKEN cDNA 2810002N01 gene 0.41 2.85 NM_028377 2900006K08Rik RIKEN cDNA 2900006K08 gene 0.36 3.06 NM_172698 4732418C07Rik RIKEN cDNA 4732418C07 gene 0.39 3.07 NM_207267 4930488E11Rik RIKEN cDNA 4930488E11 gene 0.38 3.63 NM_207527 4930504O13Rik RIKEN cDNA 4930504O13 gene 0.39 3.26 NM_198607 4930572J05Rik RIKEN cDNA 4930572J05 gene 0.41 3.20 NM_177230 4932413O14Rik RIKEN cDNA 4932413O14 gene 0.38 2.63 NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene 0.28 3.57 NM_029960 9230104L09Rik RIKEN cDNA 9230104L09 gene 0.35 3.62 NM_212473 A930008G19Rik RIKEN cDNA A930008G19 gene 0.24 3.96 ATP-binding cassette, sub-family A (ABC1), member NM_177213 Abca15 15 0.39 2.97 NM_013854 Abcf1 ATP-binding cassette, sub-family F (GCN20), member 1 0.38 3.15 NM_009594 Abl1 V-abl Abelson murine leukemia oncogene 1 0.23 2.51 NM_009338 Acat2 Acetyl-Coenzyme A acetyltransferase 2 0.39 2.54 NM_025988 Acbd4 Acyl-Coenzyme A binding domain containing 4 0.27 2.90 NM_025271 Actl7b Actin-like 7b 0.43 3.02 NM_172532 Aldh5a1 Aldhehyde dehydrogenase family 5, subfamily A1 0.37 3.30 NM_198027 Alkbh6 AlkB, alkylation repair homolog 6 (E. coli) 0.18 2.56 NM_007444 Amd1 S-adenosylmethionine decarboxylase 1 0.42 3.13 NM_033603 Amn Amnionless 0.43 3.05 NM_026904 Anapc10 Anaphase promoting complex subunit 10 0.38 2.53 NM_020581 Angptl4 Angiopoietin-like 4 0.42 2.80 NM_027480 Ankrd24 Ankyrin repeat domain 24 0.29 2.76 Acidic (leucine-rich) nuclear phosphoprotein 32 family, NM_023210 Anp32e member E 0.43 4.07 NM_009681 Ap3s1 Adaptor-related protein complex 3, sigma 1 subunit 0.40 2.97 NM_133346 Asb6 Ankyrin repeat and SOCS box-containing protein 6 0.44 2.80 NM_133768 Asl Argininosuccinate lyase 0.36 2.71 NM_145425 AV249152 Expressed sequence AV249152 0.35 2.80

219 NM_001033532 AW554918 Expressed sequence AW554918 0.44 2.65 NM_001024560 B930037P14Rik RIKEN cDNA B930037P14 gene 0.32 3.41 NM_177632 BC022623 CDNA sequence BC022623 0.45 2.83 NM_153557 BC029214 CDNA sequence BC029214 0.44 3.38 NM_009754 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.42 3.38 NM_009764 Brca1 Breast cancer 1 0.40 2.69 NM_133889 Bsdc1 BSD domain containing 1 0.39 3.31 NM_007570 Btg2 B-cell translocation gene 2, anti-proliferative 0.27 2.92 Budding uninhibited by benzimidazoles 1 homolog, beta NM_009773 Bub1b (S. cerevisiae) 0.36 2.51 NM_001008705 Bud31 BUD31 homolog (yeast) 0.27 2.72 NM_175696 C530028O21Rik RIKEN cDNA C530028O21 gene 0.43 3.55 Calcium channel, voltage-dependent, L type, alpha 1C NM_009781 Cacna1c subunit 0.41 2.77 NM_019430 Cacng3 Calcium channel, voltage-dependent, gamma subunit 3 0.37 2.93 NM_007586 Calb2 Calbindin 2 0.23 3.24 Calcium/calmodulin-dependent serine protein kinase NM_009806 Cask (MAGUK family) 0.38 2.85 NM_145595 Cbr4 Carbonyl reductase 4 0.42 3.15 NM_026964 Ccdc124 Coiled-coil domain containing 124 0.36 2.76 NM_175430 Ccdc40 Coiled-coil domain containing 40 0.37 9.48 NM_023731 Ccdc86 Coiled-coil domain containing 86 0.26 3.18 NM_007639 Cd1d1 CD1d1 antigen 0.34 2.85 NM_001039150 Cd44 CD44 antigen 0.38 2.53 NM_009853 Cd68 CD68 antigen 0.38 5.93 NM_026373 Cdk2ap2 CDK2-associated protein 2 0.33 3.72 NM_133960 Ces6 Carboxylesterase 6 0.45 2.90 NM_007691 Chek1 Checkpoint kinase 1 homolog (S. pombe) 0.36 4.42 NM_024190 Chmp1b Chromatin modifying protein 1B 0.41 2.93 NM_026885 Chmp2a Chromatin modifying protein 2A 0.40 3.34 NM_153508 Clstn3 Calsyntenin 3 0.28 3.11 NM_001003908 Cltc Clathrin, heavy polypeptide (Hc) 0.44 3.97 NM_001039551 Cnnm3 Cyclin M3 0.43 2.85 NM_133724 Cno Cappuccino 0.40 3.21 NM_019817 Copz1 Coatomer protein complex, subunit zeta 1 0.28 4.59 NM_009974 Csnk2a2 Casein kinase 2, alpha prime polypeptide 0.32 3.07 NM_001025192 Cxadr Coxsackievirus and adenovirus receptor 0.41 2.72 NM_001024926 Cyb5d2 Cytochrome b5 domain containing 2 0.23 2.88 NM_177464 D19Ertd386e DNA segment, Chr 19, ERATO Doi 386, expressed 0.34 2.70 NM_178724 D230010M03Rik RIKEN cDNA D230010M03 gene 0.36 2.66 DNA segment, Chr 6, Wayne State University 163, NM_138594 D6Wsu163e expressed 0.45 4.90 NM_010022 Dbt Dihydrolipoamide branched chain transacylase E2 0.30 3.16 NM_026538 Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.45 3.51 NM_145157 Defb19 Defensin beta 19 0.41 6.21 NM_007866 Dll3 Delta-like 3 (Drosophila) 0.42 2.71 NM_007869 Dnajc1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.44 3.04 NM_010065 Dnm1 Dynamin 1 0.38 3.27 NM_026082 Dock7 Dedicator of cytokinesis 7 0.43 2.57 NM_176913 Dpep2 Dipeptidase 2 0.38 4.07 NM_027193 Dph5 DPH5 homolog (S. cerevisiae) 0.42 3.15 NM_001034909 EG547347 Predicted gene, EG547347 0.40 2.58 NM_198303 Eif5b Eukaryotic translation initiation factor 5B 0.42 2.57 NM_007924 Ell Elongation factor RNA polymerase II 0.24 3.88 Engulfment and cell motility 1, ced-12 homolog (C. NM_080288 Elmo1 elegans) 0.32 4.06 NM_007951 Erh Enhancer of rudimentary homolog (Drosophila) 0.28 3.42 NM_026695 Etfb Electron transferring flavoprotein, beta polypeptide 0.26 3.84 NM_177070 Fbxw16 F-box and WD-40 domain protein 16 0.39 2.75 NM_134469 Fdps Farnesyl diphosphate synthetase 0.32 2.60 NM_010209 Fh1 Fumarate hydratase 1 0.21 2.67 NM_019873 Fkbpl FK506 binding protein-like 0.41 4.10 RFad1, flavin adenine dinucleotide synthetase, homolog NM_177041 Flad1 (yeast) 0.35 2.59

220 NM_146018 Flcn Folliculin 0.38 2.57 NM_021899 Foxj2 Forkhead box J2 0.43 3.06 NM_033320 Glce Glucuronyl C5-epimerase 0.39 3.42 NM_001033478 Gm1381 Gene model 1381, (NCBI) 0.42 2.53 NM_153394 Gpr156 G protein-coupled receptor 156 0.15 3.11 NM_145370 Gps1 G protein pathway suppressor 1 0.41 2.73 NM_010360 Gstm5 Glutathione S-transferase, mu 5 0.37 2.99 NM_008194 Gyk Glycerol kinase 0.45 3.57 NM_008211 H3f3b H3 histone, family 3B 0.42 2.62 NM_198962 Hcrtr2 Hypocretin (orexin) receptor 2 0.42 3.34 NM_001033432 Heca Headcase homolog (Drosophila) 0.41 3.01 NM_178194 Hist1h2be Histone cluster 1, H2be 0.30 2.78 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase- NM_173731 Hmgcll1 like 1 0.44 2.51 NM_197944 Hsh2d Hematopoietic SH2 domain containing 0.41 2.84 NM_008317 Hyal1 Hyaluronoglucosaminidase 1 0.31 2.54 NM_133662 Ier3 Immediate early response 3 0.45 2.55 NM_197889 Ifnz Interferon zeta 0.41 3.07 NM_031177 Ift122 Intraflagellar transport 122 homolog (Chlamydomonas) 0.37 3.37 NM_134126 Ift140 Intraflagellar transport 140 homolog (Chlamydomonas) 0.35 3.25 NM_033608 Igsf9 Immunoglobulin superfamily, member 9 0.43 2.64 NM_001033323 Igsf9b Immunoglobulin superfamily, member 9B 0.37 3.24 NM_001003829 Jph4 Junctophilin 4 0.39 2.53 NM_010590 Jub Ajuba 0.25 3.74 Potassium voltage-gated channel, Isk-related subfamily, NM_008424 Kcne1 member 1 0.34 3.92 NM_134073 Kctd9 Potassium channel tetramerisation domain containing 9 0.40 3.03 NM_010628 Kif9 Kinesin family member 9 0.24 2.52 NM_010673 Krtap6-2 Keratin associated protein 6-2 0.38 3.00 NM_010702 Lect2 Leukocyte cell-derived chemotaxin 2 0.41 4.20 NM_001033250 Lemd1 LEM domain containing 1 0.45 3.05 NM_026719 Lmbrd1 LMBR1 domain containing 1 0.42 2.75 NM_033325 Loxl2 Lysyl oxidase-like 2 0.37 3.17 NM_025948 Lsm14a LSM14 homolog A (SCD6, S. cerevisiae) 0.36 2.72 NM_008523 Ltk Leukocyte tyrosine kinase 0.38 2.68 NM_029662 Mfsd2 Major facilitator superfamily domain containing 2 0.20 3.37 NM_019944 Mnx1 Motor neuron and pancreas homeobox 1 0.31 3.80 NM_025606 Mrpl16 Mitochondrial ribosomal protein L16 0.37 3.94 NM_026498 Mrps11 Mitochondrial ribosomal protein S11 0.29 2.61 NM_172761 Mthfsd Methenyltetrahydrofolate synthetase domain containing 0.45 2.52 NM_133767 Mtif2 Mitochondrial translational initiation factor 2 0.42 3.69 NM_023166 Mtvr2 Mammary tumor virus receptor 2 0.33 4.17 NM_013605 Muc1 Mucin 1, transmembrane 0.34 2.54 NM_177619 Myst2 MYST histone acetyltransferase 2 0.26 3.14 NM_026890 Ngdn Neuroguidin, EIF4E binding protein 0.40 2.64 NM_010920 Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.35 2.98 NM_008707 Nmt1 N-myristoyltransferase 1 0.39 2.68 NM_153529 Nrn1 Neuritin 1 0.40 3.21 NM_016773 Nucb2 Nucleobindin 2 0.24 3.27 Nudix (nucleoside diphosphate linked moiety X)-type NM_008637 Nudt1 motif 1 0.31 3.11 Oligonucleotide/oligosaccharide-binding fold containing NM_175360 Obfc1 1 0.41 2.64 NM_146573 Olfr1002 Olfactory receptor 1002 0.45 2.56 NM_207157 Olfr1333 Olfactory receptor 1333 0.35 2.94 NM_146283 Olfr1366 Olfactory receptor 1366 0.19 3.30 NM_146472 Olfr1384 Olfactory receptor 1384 0.42 3.20 NM_001011741 Olfr1386 Olfactory receptor 1386 0.37 2.53 NM_020513 Olfr1508 Olfactory receptor 1508 0.41 2.52 NM_020598 Olfr17 Olfactory receptor 17 0.42 3.88 NM_146269 Olfr247 Olfactory receptor 247 0.29 3.09 NM_147041 Olfr57 Olfactory receptor 57 0.35 4.89 NM_001003717 Osbpl8 Oxysterol binding protein-like 8 0.45 4.12 NM_001013783 OTTMUSG00000005491 Predicted gene, OTTMUSG00000005491 0.35 3.03

221 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, NM_025939 Paics succinocarboxamide synthetase 0.36 3.58 NM_008782 Pax5 Paired box gene 5 0.37 6.68 NM_009545 Pcgf2 Polycomb group ring finger 2 0.41 3.53 NM_026850 Pdcl3 Phosducin-like 3 0.45 2.84 NM_011070 Pfdn2 Prefoldin 2 0.40 2.83 Pleckstrin homology domain containing, family B NM_013746 Plekhb1 (evectins) member 1 0.45 2.60 NM_001039509 Pnkd Paroxysmal nonkinesiogenic dyskinesia 0.42 2.96 NM_145145 Pomt1 Protein-O-mannosyltransferase 1 0.44 4.26 NM_175363 Pphln1 Periphilin 1 0.40 2.58 NM_028292 Ppme1 Protein phosphatase methylesterase 1 0.43 3.11 NM_013636 Ppp1cc Protein phosphatase 1, catalytic subunit, gamma isoform 0.37 2.62 NM_138605 Ppp1r3f Protein phosphatase 1, regulatory (inhibitor) subunit 3F 0.45 2.67 Protein phosphatase 3, regulatory subunit B, alpha NM_024459 Ppp3r1 isoform (calcineurin B, type I) 0.35 2.83 NM_008917 Ppt1 Palmitoyl-protein thioesterase 1 0.28 2.79 NM_025596 Prelid1 PRELI domain containing 1 0.34 3.14 NM_008925 Prkcsh Protein kinase C substrate 80K-H 0.37 3.69 NM_053268 Rasa2 RAS p21 protein activator 2 0.43 2.58 Regulator of chromosome condensation (RCC1) and NM_027764 Rcbtb1 BTB (POZ) domain containing protein 1 0.33 2.57 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 0.32 3.08 NM_175372 Rdh13 Retinol dehydrogenase 13 (all-trans and 9-cis) 0.45 2.76 NM_177370 Rhbdd3 Rhomboid domain containing 3 0.41 2.69 NM_021375 Rhbg Rhesus blood group-associated B glycoprotein 0.45 2.58 NM_007483 Rhob Ras homolog gene family, member B 0.40 2.66 NM_027445 Rnf167 Ring finger protein 167 0.43 3.24 NM_023133 Rps19 Ribosomal protein S19 0.30 3.39 NM_173450 Rpusd2 RNA pseudouridylate synthase domain containing 2 0.42 2.74 NM_025546 Rsl1d1 Ribosomal L1 domain containing 1 0.25 2.70 NM_130892 Rtn4ip1 Reticulon 4 interacting protein 1 0.45 2.66 NM_009115 S100b S100 protein, beta polypeptide, neural 0.34 3.03 NM_013928 Schip1 Schwannomin interacting protein 1 0.42 3.60 NM_009160 Sftpd Surfactant associated protein D 0.34 2.80 Solute carrier family 22 (organic cation transporter), NM_008767 Slc22a18 member 18 0.22 2.77 NM_011773 Slc30a3 Solute carrier family 30 (zinc transporter), member 3 0.40 2.96 Solute carrier family 37 (glycerol-3-phosphate NM_153062 Slc37a1 transporter), member 1 0.41 2.70 SWI/SNF related, matrix associated, actin dependent NM_011416 Smarca2 regulator of chromatin, subfamily a, member 2 0.38 3.26 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing NM_007958 Smarcad1 DEAD/H box 1` 0.45 4.36 NM_134034 Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 0.36 2.51 NM_001038627 Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.35 2.66 NM_172926 Snx14 Sorting nexin 14 0.32 2.51 NM_001025612 Snx22 Sorting nexin 22 0.35 2.78 NM_009238 Sox4 SRY-box containing gene 4 0.42 2.71 NM_013672 Sp1 Trans-acting transcription factor 1 0.34 3.13 NM_031183 Sp6 Trans-acting transcription factor 6 0.42 2.98 Signal peptidase complex subunit 2 homolog (S. NM_025668 Spcs2 cerevisiae) 0.38 3.35 NM_011461 Spic Spi-C transcription factor (Spi-1/PU.1 related) 0.36 2.91 NM_145584 Spon1 Spondin 1, (f-spondin) extracellular matrix protein 0.38 2.65 NM_020493 Srf Serum response factor 0.43 3.17 NM_019641 Stmn1 Stathmin 1 0.43 2.78 NM_146177 Suv420h2 Suppressor of variegation 4-20 homolog 2 (Drosophila) 0.26 2.89 NM_181516 Taz Tafazzin 0.41 2.91 NM_026456 Tceb1 Transcription elongation factor B (SIII), polypeptide 1 0.35 3.37 NM_177726 Tgm6 Transglutaminase 6 0.43 2.56 NM_153552 Thoc1 THO complex 1 0.37 3.18

222 Transmembrane emp24 protein transport domain NM_025458 Tmed6 containing 6 0.39 2.92 NM_029649 Tmem101 Transmembrane protein 101 0.37 5.25 NM_001033393 Tmem104 Transmembrane protein 104 0.35 3.12 NM_175145 Tmem127 Transmembrane protein 127 0.22 3.19 NM_133706 Tmem97 Transmembrane protein 97 0.39 3.01 NM_016788 Tnk2 Tyrosine kinase, non-receptor, 2 0.25 3.66 Translocase of outer mitochondrial membrane 40 NM_016871 Tomm40 homolog (yeast) 0.32 2.65 NM_134097 Topors Topoisomerase I binding, arginine/serine-rich 0.43 2.57 NM_001024206 Trappc1 Trafficking protein particle complex 1 0.26 3.04 NM_029979 Trim35 Tripartite motif-containing 35 0.42 5.08 Transformation related protein 53 inducible nuclear NM_178111 Trp53inp2 protein 2 0.36 2.70 NM_133795 Ttc1 Tetratricopeptide repeat domain 1 0.33 3.34 NM_011654 Tuba1b Tubulin, alpha 1B 0.39 2.64 NM_018879 Tusc4 Tumor suppressor candidate 4 0.29 4.65 NM_015762 Txnrd1 Thioredoxin reductase 1 0.39 2.52 NM_011664 Ubb Ubiquitin B 0.33 2.71 NM_146144 Usp1 Ubiquitin specific peptdiase 1 0.44 3.67 NM_178635 Uvrag UV radiation resistance associated gene 0.40 4.94 Valosin containing protein (p97)/p47 complex NM_173443 Vcpip1 interacting protein 1 0.43 4.34 Ventricular zone expressed PH domain homolog 1 NM_145820 Veph1 (zebrafish) 0.32 2.68 NM_172470 Wdr35 WD repeat domain 35 0.42 4.00 NM_001025375 Wdr61 WD repeat domain 61 0.28 2.94 NM_026156 Xab2 XPA binding protein 2 0.39 2.56 NM_177310 Xpnpep3 X-prolyl aminopeptidase (aminopeptidase P) 3, putative 0.24 3.30 NM_026846 Zfand2b Zinc finger, AN1 type domain 2B 0.35 2.82 NM_198322 Zfp273 Zinc finger protein 273 0.40 2.63 NM_172794 Zfp454 Zinc finger protein 454 0.36 2.77 NM_001001186 Zfp456 Zinc finger protein 456 0.42 2.98 NM_144523 Zfp622 Zinc finger protein 622 0.28 3.55 NM_028913 Zfp819 Zinc finger protein 819 0.43 3.14 NM_025472 0.36 3.50 NM_176925 0.37 3.37 NM_026297 0.22 3.37 NM_175354 0.21 2.59 NM_028793 0.24 3.91 NM_001040398 0.35 3.40 NM_027681 0.45 4.57

SUPPLEMENTAL TABLE S20: Genes Demonstrating Decreased Phospho-CREB Binding in Resilient Animals Compared to Susceptible Animals(p<0.001)

Defeat Fold Resiliency Fold Accession Number Symbol Name Change Change NM_025946 2010100O12Rik RIKEN cDNA 2010100O12 gene 2.47 0.33 NM_001025573 2010107G12Rik RIKEN cDNA 2010107G12 gene 2.68 0.38 NM_172398 2310005E10Rik RIKEN cDNA 2310005E10 gene 2.26 0.30 NM_025865 2310030G06Rik RIKEN cDNA 2310030G06 gene 2.13 0.34 NM_026643 2410017P07Rik RIKEN cDNA 2410017P07 gene 2.32 0.29 NM_183287 2610318N02Rik RIKEN cDNA 2610318N02 gene 2.29 0.34 NM_027568 4733401H21Rik RIKEN cDNA 4733401H21 gene 2.91 0.33 NM_178388 4930425N13Rik RIKEN cDNA 4930425N13 gene 2.33 0.29 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 3.86 0.36 NM_025744 4933404M02Rik RIKEN cDNA 4933404M02 gene 2.50 0.32 NM_177314 5330439B14Rik RIKEN cDNA 5330439B14 gene 2.59 0.39 NM_146091 5730596K20Rik RIKEN cDNA 5730596K20 gene 2.54 0.38 NM_001039720 9030619P08Rik RIKEN cDNA 9030619P08 gene 2.87 0.38 NM_177668 A030001H23Rik RIKEN cDNA A030001H23 gene 2.27 0.35 NM_175687 A230050P20Rik RIKEN cDNA A230050P20 gene 2.22 0.35 NM_007378 Abca4 ATP-binding cassette, sub-family A (ABC1), member 4 3.37 0.36

223 NM_080633 Aco2 Aconitase 2, mitochondrial 2.17 0.33 NM_013455 Acr Preproacrosin 2.53 0.27 NM_007402 Adam7 A disintegrin and metallopeptidase domain 7 2.58 0.34 NM_009626 Adh7 Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 3.03 0.36 NM_001033476 Ahnak2 AHNAK nucleoprotein 2 2.33 0.30 NM_013465 Ahsg Alpha-2-HS-glycoprotein 2.46 0.36 NM_173016 AI427515 Expressed sequence AI427515 2.41 0.36 NM_144903 Aldob Aldolase 2, B isoform 2.73 0.29 NM_178655 Ank2 Ankyrin 2, brain 2.17 0.35 NM_013470 Anxa3 Annexin A3 2.69 0.36 NM_182994 Arl5a ADP-ribosylation factor-like 5A 2.11 0.38 NM_194347 AY358078 CDNA sequence AY358078 2.19 0.36 NM_080640 Baalc Brain and acute leukemia, cytoplasmic 2.56 0.36 NM_178446 BC013481 CDNA sequence BC013481 3.19 0.25 NM_146215 BC025546 CDNA sequence BC025546 2.30 0.26 NM_001033001 BC065397 CDNA sequence BC065397 2.88 0.32 NM_080708 Bmp2k BMP2 inducible kinase 2.13 0.38 NM_030178 Brpf1 Bromodomain and PHD finger containing, 1 3.00 0.28 NM_138678 Butr1 Butyrophilin related 1 2.58 0.35 NM_207233 C1ql2 Complement component 1, q subcomponent-like 2 2.60 0.37 NM_028296 Car10 Carbonic anhydrase 10 3.02 0.34 NM_007617 Cav3 Caveolin 3 2.36 0.38 NM_001033654 Ccdc139 Coiled-coil domain containing 139 3.09 0.30 NM_201372 Ccdc84 Coiled-coil domain containing 84 2.73 0.25 NM_172405 Ccdc98 Coiled-coil domain containing 98 2.11 0.27 NM_011333 Ccl2 Chemokine (C-C motif) ligand 2 2.49 0.34 NM_007639 Cd1d1 CD1d1 antigen 2.64 0.35 NM_027276 Cdc16 CDC16 cell division cycle 16 homolog (S. cerevisiae) 2.25 0.33 NM_007671 Cdkn2c Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.60 0.36 NM_018818 Chm Choroidermia 2.12 0.34 NM_029633 Clasp2 CLIP associating protein 2 2.27 0.30 NM_178697 Clca5 Chloride channel calcium activated 5 2.55 0.35 NM_027218 Clec4b1 C-type lectin domain family 4, member b1 2.37 0.38 NM_028798 Crct1 Cysteine-rich C-terminal 1 2.81 0.38 NM_028288 Cul4b Cullin 4B 3.81 0.24 NM_009140 Cxcl2 Chemokine (C-X-C motif) ligand 2 2.44 0.32 NM_007807 Cybb Cytochrome b-245, beta polypeptide 2.43 0.34 NM_177382 Cyp2r1 Cytochrome P450, family 2, subfamily r, polypeptide 1 2.15 0.38 NM_177307 Cyp4f39 Cytochrome P450, family 4, subfamily f, polypeptide 39 3.23 0.34 NM_027030 Dcps Decapping enzyme, scavenger 2.27 0.32 NM_010029 Ddx4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 4.49 0.21 NM_027156 Ddx51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.39 0.33 NM_007843 Defb1 Defensin beta 1 2.68 0.37 NM_013756 Defb3 Defensin beta 3 2.23 0.36 NM_001034910 Defb42 Defensin beta 42 2.25 0.35 NM_001025296 Dffa DNA fragmentation factor, alpha subunit 2.79 0.36 NM_001025947 Dnm1l Dynamin 1-like 2.88 0.27 NM_001013826 Dupd1 Dual specificity phosphatase and pro isomerase domain containing 1 2.15 0.37 NM_001039556 E130016E03Rik RIKEN cDNA E130016E03 gene 2.46 0.38 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 2.50 0.28 NM_172504 EG212225 Predicted gene, EG212225 2.25 0.30 NM_010135 Enah Enabled homolog (Drosophila) 2.46 0.38 NM_027123 Fastkd3 FAST kinase domains 3 2.16 0.34 NM_175530 Fbxo46 F-box protein 46 2.72 0.36 NM_019873 Fkbpl FK506 binding protein-like 2.24 0.38 NM_029798 Flywch2 FLYWCH family member 2 2.13 0.38 NM_144878 Fmo4 Flavin containing monooxygenase 4 2.31 0.35 NM_028407 Gcap14 Granule cell antiserum positive 14 2.20 0.35 NM_008123 Gja8 Gap junction membrane channel protein alpha 8 3.46 0.22 NM_001033477 Gm1322 Gene model 1322, (NCBI) 2.62 0.35 NM_008141 Gnat2 Guanine nucleotide binding protein, alpha transducing 2 2.48 0.36 Guanine nucleotide binding protein (G protein), gamma transducing NM_010314 Gngt1 activity polypeptide 1 2.89 0.22 NM_001035122 Golm1 Golgi membrane protein 1 2.43 0.29

224 NM_008172 Grin2d Glutamate receptor, ionotropic, NMDA2D (epsilon 4) 2.57 0.37 NM_008174 Grm8 Glutamate receptor, metabotropic 8 2.58 0.38 NM_010360 Gstm5 Glutathione S-transferase, mu 5 2.77 0.33 NM_008178 Gsx1 GS homeobox 1 3.94 0.31 NM_133256 Gsx2 GS homeobox 2 2.43 0.34 NM_026816 Gtf2f2 General transcription factor IIF, polypeptide 2 2.16 0.28 NM_144835 Heatr1 HEAT repeat containing 1 2.41 0.38 NM_010432 Hipk1 Homeodomain interacting protein kinase 1 2.58 0.33 NM_023422 Hist1h2bc Histone cluster 1, H2bc 2.82 0.25 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta- NM_008295 Hsd3b5 isomerase 5 3.00 0.32 NM_028957 Hyal5 Hyaluronoglucosaminidase 5 2.30 0.24 NM_010491 Iapp Islet amyloid polypeptide 2.39 0.35 NM_198653 Iars2 Isoleucine-tRNA synthetase 2, mitochondrial 3.10 0.39 NM_011940 Ifi202b Interferon activated gene 202B 2.89 0.32 NM_183029 Igf2bp2 Insulin-like growth factor 2 mRNA binding protein 2 2.46 0.29 NM_008366 Il2 Interleukin 2 2.89 0.30 NM_013563 Il2rg Interleukin 2 receptor, gamma chain 4.24 0.31 NM_008370 Il5ra Interleukin 5 receptor, alpha 4.09 0.35 NM_027927 Ints12 Integrator complex subunit 12 2.44 0.38 NM_153414 Ints9 Integrator complex subunit 9 2.15 0.32 NM_011365 Itsn2 Intersectin 2 2.36 0.27 Potassium voltage-gated channel, subfamily H (eag-related), member NM_172805 Kcnh5 5 5.27 0.29 NM_019659 Kcnj1 Potassium inwardly-rectifying channel, subfamily J, member 1 2.54 0.34 NM_001012434 Kctd14 Potassium channel tetramerisation domain containing 14 4.54 0.25 NM_010629 Kifap3 Kinesin-associated protein 3 4.02 0.16 NM_010648 Klra3 Killer cell lectin-like receptor, subfamily A, member 3 2.14 0.30 NM_008526 Klrb1d Killer cell lectin-like receptor subfamily B member 1D 5.09 0.29 NM_001039666 Krt40 Keratin 40 2.29 0.36 NM_010695 Lcn4 Lipocalin 4 2.56 0.38 NM_001037918 Lipt1 Lipoyltransferase 1 2.98 0.37 NM_026719 Lmbrd1 LMBR1 domain containing 1 3.21 0.24 NM_177178 Lmbrd2 LMBR1 domain containing 2 2.54 0.38 NM_207222 Lmo3 LIM domain only 3 2.38 0.37 NM_022882 Lpin2 Lipin 2 2.42 0.21 NM_178725 Lrrc4c Leucine rich repeat containing 4C 2.82 0.35 NM_133688 Lyrm5 LYR motif containing 5 2.14 0.31 NM_017372 Lyzs Lysozyme 2.20 0.36 NM_011839 Mab21l2 Mab-21-like 2 (C. elegans) 2.70 0.37 NM_175296 Mael Maelstrom homolog (Drosophila) 2.18 0.32 NM_134012 Mbtd1 Mbt domain containing 1 2.36 0.37 NM_008563 Mcm3 Minichromosome maintenance deficient 3 (S. cerevisiae) 2.51 0.29 NM_001039214 Mex3c Mex3 homolog C (C. elegans) 2.82 0.25 NM_008598 Mgmt O-6-methylguanine-DNA methyltransferase 2.34 0.30 NM_011746 Mkrn3 Makorin, ring finger protein, 3 2.35 0.26 NM_013826 Mocs2 Molybdenum cofactor synthesis 2 2.65 0.33 NM_134092 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein 2.16 0.30 NM_027134 Mtfmt Mitochondrial methionyl-tRNA formyltransferase 3.03 0.24 NM_028860 Mtmr3 Myotubularin related protein 3 2.65 0.30 NM_013792 Naglu Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) 2.44 0.34 NM_153126 Nat10 N-acetyltransferase 10 2.17 0.24 NM_010874 Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.78 0.35 NM_023172 Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 3.59 0.23 NM_025424 Nenf Neuron derived neurotrophic factor 2.41 0.31 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent NM_010901 Nfatc3 3 3.33 0.38 NM_133192 Npffr2 Neuropeptide FF receptor 2 2.43 0.35 NM_134122 Nrm Nurim (nuclear envelope membrane protein) 2.55 0.34 NM_026330 Nsmce1 Non-SMC element 1 homolog (S. cerevisiae) 2.18 0.35 NM_026004 Nt5c3 5'-nucleotidase, cytosolic III 2.20 0.34 Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. NM_030250 Nus1 cerevisiae) 2.20 0.38 NM_146921 Olfr1 Olfactory receptor 1 2.56 0.35 NM_146753 Olfr1195 Olfactory receptor 1195 2.25 0.35

225 NM_146897 Olfr1214 Olfactory receptor 1214 2.40 0.38 NM_146459 Olfr1215 Olfactory receptor 1215 2.47 0.34 NM_146794 Olfr1263 Olfactory receptor 1263 2.27 0.33 NM_146404 Olfr1289 Olfactory receptor 1289 4.97 0.20 NM_146403 Olfr1295 Olfactory receptor 1295 2.93 0.34 NM_146362 Olfr1312 Olfactory receptor 1312 2.15 0.33 NM_147003 Olfr139 Olfactory receptor 139 2.49 0.29 NM_001011775 Olfr1419 Olfactory receptor 1419 2.20 0.37 NM_001011778 Olfr257 Olfactory receptor 257 2.37 0.32 NM_147036 Olfr283 Olfactory receptor 283 2.52 0.26 NM_001011863 Olfr406 Olfactory receptor 406 2.87 0.27 NM_001011528 Olfr456 Olfactory receptor 456 2.13 0.38 NM_001001805 Olfr576 Olfactory receptor 576 3.63 0.32 NM_147115 Olfr578 Olfactory receptor 578 3.26 0.24 NM_147119 Olfr632 Olfactory receptor 632 3.82 0.31 NM_146392 Olfr720 Olfactory receptor 720 2.49 0.37 NM_146555 Olfr805 Olfactory receptor 805 2.15 0.34 NM_146562 Olfr862 Olfactory receptor 862 2.41 0.38 NM_205822 Omt2b Oocyte maturation, beta 2.39 0.34 NM_198661 Oog2 Oogenesin 2 2.48 0.23 NM_027950 Osgin1 Oxidative stress induced growth inhibitor 1 2.78 0.23 NM_001025244 OTTMUSG00000002177 Predicted gene, OTTMUSG00000002177 2.17 0.31 NM_177865 OTTMUSG00000008540 Predicted gene, OTTMUSG00000008540 2.84 0.37 NM_177460 Parp16 Poly (ADP-ribose) polymerase family, member 16 2.15 0.34 NM_030253 Parp9 Poly (ADP-ribose) polymerase family, member 9 2.31 0.31 NM_053133 Pcdhb8 Protocadherin beta 8 2.48 0.38 NM_033586 Pcdhga12 Protocadherin gamma subfamily A, 12 2.24 0.38 NM_033587 Pcdhga12 Protocadherin gamma subfamily A, 12 2.16 0.38 NM_033583 Pcdhga12 Protocadherin gamma subfamily A, 12 3.02 0.32 NM_011067 Per3 Period homolog 3 (Drosophila) 2.68 0.38 NM_029293 Phpt1 Phosphohistidine phosphatase 1 2.94 0.35 NM_172992 Phtf2 Putative homeodomain transcription factor 2 2.59 0.32 Phosphatidylinositol 3-kinase, C2 domain containing, gamma NM_011084 Pik3c2g polypeptide 2.17 0.35 NM_013631 Pklr Pyruvate kinase liver and red blood cell 2.57 0.34 NM_011099 Pkm2 Pyruvate kinase, muscle 2.39 0.36 NM_026163 Pkp2 Plakophilin 2 2.90 0.37 NM_201394 Plec1 Plectin 1 2.59 0.38 NM_007548 Prdm1 PR domain containing 1, with ZNF domain 2.49 0.38 NM_011174 Prh1 Proline rich protein HaeIII subfamily 1 2.89 0.26 NM_031499 Prh1 Proline rich protein HaeIII subfamily 1 2.81 0.35 NM_008926 Prkg2 Protein kinase, cGMP-dependent, type II 2.11 0.31 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 2.21 0.36 NM_011166 Prl6a1 Prolactin family 6, subfamily a, member 1 2.14 0.38 NM_011168 Prl7a2 Prolactin family 7, subfamily a, member 2 2.26 0.37 NM_011120 Prl7d1 Prolactin family 7, subfamily d, member 1 2.58 0.39 NM_008937 Prox1 Prospero-related homeobox 1 2.79 0.30 NM_028447 Prrc1 Proline-rich coiled-coil 1 2.86 0.33 NM_008941 Prss7 Protease, serine, 7 (enterokinase) 2.12 0.36 NM_011966 Psma4 Proteasome (prosome, macropain) subunit, alpha type 4 2.89 0.35 NM_011877 Ptpn21 Protein tyrosine phosphatase, non-receptor type 21 2.55 0.29 NM_001033172 Rab11fip2 RAB11 family interacting protein 2 (class I) 2.34 0.29 NM_011235 Rad51l3 RAD51-like 3 (S. cerevisiae) 2.21 0.38 NM_001011877 Rnase11 Ribonuclease, RNase A family, 11 (non-active) 2.12 0.33 NM_033604 Rnf111 Ring finger 111 3.15 0.34 NM_199201 RP23-331L12.8 CMRF-35-like molecule 3 2.66 0.30 NM_019642 Rpn2 Ribophorin II 2.64 0.28 NM_001013376 Rpp38 Ribonuclease P/MRP 38 subunit (human) 2.82 0.29 NM_199422 S100a7a S100 calcium binding protein A7A 2.22 0.35 NM_020483 Sap30bp SAP30 binding protein 2.53 0.27 NM_007644 Scarb2 Scavenger receptor class B, member 2 3.45 0.33 NM_013883 Scmh1 Sex comb on midleg homolog 1 2.27 0.33 NM_012009 Sh2d1b1 SH2 domain protein 1B1 2.24 0.34 NM_172937 Shprh SNF2 histone linker PHD RING helicase 2.30 0.31

226 Sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. NM_022432 Sirt2 cerevisiae) 8.61 0.38 NM_011384 Six6 Sine oculis-related homeobox 6 homolog (Drosophila) 2.42 0.29 NM_175034 Slc24a5 Solute carrier family 24, member 5 2.17 0.35 Solute carrier family 7 (cationic amino acid transporter, y+ system), NM_007515 Slc7a3 member 3 2.24 0.32 NM_177353 Slc9a7 Solute carrier family 9 (sodium/hydrogen exchanger), isoform 7 2.42 0.36 NM_029273 Slitrk5 SLIT and NTRK-like family, member 5 2.41 0.34 NM_019710 Smc1a Structural maintenance of chromosomes 1A 2.67 0.35 NM_008574 Smcp Sperm mitochondria-associated cysteine-rich protein 2.38 0.34 NM_176996 Smo Smoothened homolog (Drosophila) 2.34 0.36 NM_013669 Snap91 Synaptosomal-associated protein 91 2.24 0.35 NM_172926 Snx14 Sorting nexin 14 2.17 0.33 NM_028852 Spatc1 Spermatogenesis and centriole associated 1 2.24 0.37 NM_178628 Spg3a Spastic paraplegia 3A homolog (human) 2.30 0.39 NM_182990 Ssrp1 Structure specific recognition protein 1 2.18 0.27 NM_009216 Sstr1 Somatostatin receptor 1 2.15 0.34 NM_178749 Stk32a Serine/threonine kinase 32A 2.13 0.37 NM_172294 Sulf1 Sulfatase 1 2.69 0.36 NM_016771 Sult1d1 Sulfotransferase family 1D, member 1 2.18 0.33 NM_022724 Suv39h2 Suppressor of variegation 3-9 homolog 2 (Drosophila) 2.22 0.32 NM_028052 Synpr Synaptoporin 4.23 0.30 NM_207029 Tas2r129 Taste receptor, type 2, member 129 2.45 0.36 NM_032005 Tbx19 T-box 19 2.23 0.35 NM_026305 Tceb2 Transcription elongation factor B (SIII), polypeptide 2 3.51 0.33 NM_013688 Tcte1 T-complex-associated testis expressed 1 3.79 0.29 NM_054089 Tgs1 Trimethylguanosine synthase homolog (S. cerevisiae) 3.16 0.35 NM_013897 Timm8b Translocase of inner mitochondrial membrane 8 homolog b (yeast) 3.85 0.33 NM_027992 Tmem106b Transmembrane protein 106B 2.46 0.35 NM_176979 Topbp1 Topoisomerase (DNA) II beta binding protein 3.22 0.37 NM_175114 Trak1 Trafficking protein, kinesin binding 1 2.58 0.24 NM_001024206 Trappc1 Trafficking protein particle complex 1 2.78 0.33 NM_197987 Trim37 Tripartite motif protein 37 3.81 0.29 NM_001013616 Trim6 Tripartite motif protein 6 2.66 0.31 NM_032000 Trps1 Trichorhinophalangeal syndrome I (human) 2.27 0.33 NM_172253 Twistnb TWIST neighbor 2.31 0.36 NM_019562 Uchl5 Ubiquitin carboxyl-terminal esterase L5 2.66 0.19 NM_011671 Ucp2 Uncoupling protein 2 (mitochondrial, proton carrier) 3.30 0.28 NM_134196 V1re7 Vomeronasal 1 receptor, E7 2.19 0.31 NM_145842 V1re9 Vomeronasal 1 receptor, E9 3.24 0.28 NM_134217 V1rh8 Vomeronasal 1 receptor, H8 3.61 0.20 NM_011701 Vim Vimentin 2.96 0.28 NM_011702 Vip Vasoactive intestinal polypeptide 2.39 0.36 NM_146039 Wdr60 WD repeat domain 60 2.41 0.35 NM_016875 Ybx2 Y box protein 2 2.17 0.21 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation NM_011739 Ywhaq protein, theta polypeptide 2.18 0.38 NM_028325 Zcchc12 Zinc finger, CCHC domain containing 12 3.23 0.30 NM_017467 Zfp316 Zinc finger protein 316 5.49 0.37 NM_001013745 Zfp57 Zinc finger protein 57 3.10 0.22 NM_153194 Zfp740 Zinc finger protein 740 2.12 0.32 NM_177263 Zhx3 Zinc fingers and homeoboxes 3 2.49 0.39 NM_026107 Zkscan6 Zinc finger with KRAB and SCAN domains 6 2.56 0.27 NM_183292 2.76 0.37 NM_146422 3.32 0.34 NM_172419 3.05 0.32 NM_001033152 2.22 0.34 NM_026649 4.59 0.22 NM_207226 2.58 0.35 NM_133695 2.77 0.30 NM_001033809 2.69 0.33 NM_175010 2.29 0.36 NM_001037169 2.48 0.39 NM_019427 2.85 0.30 NM_178391 2.42 0.29

227 NM_177895 3.18 0.35 NM_153168 2.31 0.37

SUPPLEMENTAL TABLE S21: Genes Demonstrating Reversal of Decreased Repressive DimethylK9/K27-H3 Methylation by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

Defeat Fold Resiliency Fold Imipramine Fold Accession Number Symbol Name Change Change Change ATP-binding cassette, sub-family G NM_009593 Abcg1 (WHITE), member 1 0.56 1.56 1.43 NM_145444 Acot5 Acyl-CoA thioesterase 5 0.69 1.37 1.37 NM_001033966 Ak2 Adenylate kinase 2 0.72 1.57 1.37 NM_001033790 B020004J07Rik RIKEN cDNA B020004J07 gene 0.54 1.42 1.44 NM_145577 BC023179 CDNA sequence BC023179 0.70 1.51 1.37 NM_199150 BC049730 CDNA sequence BC049730 0.62 1.38 1.30 Bone gamma-carboxyglutamate protein, NM_031368 Bglap-rs1 related sequence 1 0.58 1.51 1.38 NM_178245 Bsx Brain specific homeobox 0.69 1.45 1.43 Cytochrome P450, family 2, subfamily c, NM_001011707 Cyp2c66 polypeptide 66 0.60 1.38 1.30 Development and differentiation NM_001004364 Ddef2 enhancing factor 2 0.66 1.67 1.37 NM_001009947 Dock11 Dedicator of cytokinesis 11 0.68 1.72 1.38 NM_177890 EG233164 Predicted gene, EG233164 0.67 1.55 1.42 NM_001005425 Gm1008 Gene model 1008, (NCBI) 0.68 1.39 1.48 NM_010417 Heph Hephaestin 0.61 1.69 1.65 Hydroxysteroid (17-beta) dehydrogenase NM_198030 Hsd17b13 13 0.59 1.38 1.56 NM_001037918 Lipt1 Lipoyltransferase 1 0.70 1.45 1.36 NM_008866 Lypla1 Lysophospholipase 1 0.54 1.56 1.53 NM_147016 Olfr1049 Olfactory receptor 1049 0.73 1.39 1.58 NM_001011735 Olfr1066 Olfactory receptor 1066 0.51 1.69 1.58 NM_146406 Olfr1076 Olfactory receptor 1076 0.69 1.58 1.42 NM_146849 Olfr1157 Olfactory receptor 1157 0.60 1.46 1.41 NM_146485 Olfr183 Olfactory receptor 183 0.73 1.48 1.31 NM_001011810 Olfr485 Olfactory receptor 485 0.67 1.49 1.39 NM_001011858 Olfr504 Olfactory receptor 504 0.73 1.38 1.30

NM_001034101 OTTMUSG00000010537 Predicted gene, OTTMUSG00000010537 0.64 1.41 1.33 Par-3 (partitioning defective 3) homolog NM_001013580 Pard3 (C. elegans) 0.68 1.38 1.43 NM_029404 Phf14 PHD finger protein 14 0.65 1.37 1.39 NM_029406 Pih1d1 PIH1 domain containing 1 0.68 1.47 1.35 NM_009005 Rab7 RAB7, member RAS oncogene family 0.66 1.74 1.47 RalBP1 associated Eps domain NM_009048 Reps1 containing protein 0.72 1.39 1.32 NM_020509 Retnla Resistin like alpha 0.55 1.41 1.58 NM_025934 Riok2 RIO kinase 2 (yeast) 0.52 1.48 1.30 Sep (O-phosphoserine) tRNA:Sec NM_172490 Sepsecs (selenocysteine) tRNA synthase 0.70 1.67 1.34 NM_012009 Sh2d1b1 SH2 domain protein 1B1 0.56 1.41 1.36 Solute carrier family 7 (cationic amino NM_177802 Slc7a15 acid transporter, y+ system), member 15 0.59 1.42 1.44 Small nuclear ribonucleoprotein NM_021336 Snrpa1 polypeptide A' 0.73 1.60 1.30 Spermatogenesis associated glutamate NM_025759 Speer4d (E)-rich protein 4d 0.66 1.63 1.39 Synovial sarcoma, X member B, NM_199319 Ssxb5 breakpoint 5 0.73 1.41 1.36 NM_001001297 Thnsl1 Threonine synthase-like 1 (bacterial) 0.60 1.36 1.30 NM_027495 Tmem144 Transmembrane protein 144 0.62 1.46 1.37 NM_011640 Trp53 Transformation related protein 53 0.69 1.42 1.30

228 UDP glucuronosyltransferase 1 family, NM_201641 Ugt1a7c polypeptide A7C 0.72 1.39 1.35 NM_207545 V1rd17 Vomeronasal 1 receptor, D17 0.59 1.52 1.56 NM_207618 V1rd18 Vomeronasal 1 receptor, D18 0.62 1.57 1.34 NM_207546 V1rd20 Vomeronasal 1 receptor, D20 0.53 1.47 1.51 NM_134243 V1rh20 Vomeronasal 1 receptor, H20 0.70 1.45 1.48 NM_134215 V1rh6 Vomeronasal 1 receptor, H6 0.58 1.43 1.49 NM_009487 V2r10 Vomeronasal 2, receptor, 10 0.67 1.44 1.43 NM_001012704 Wfdc13 WAP four-disulfide core domain 13 0.61 1.37 1.39 NM_173364 Zfp445 Zinc finger protein 445 0.67 1.71 1.57 NM_001002780 0.57 1.48 1.40

SUPPLEMENTAL TABLE S22: Genes Demonstrating Reversal of Increased Repressive DimethylK9/K27-H3 Methylation by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

Defeat Fold Resiliency Fold Imipramine Fold Accession Number Symbol Name Change Change Change NM_053102 15-Sep Selenoprotein 1.52 0.61 0.53 NM_029335 1700026D08Rik RIKEN cDNA 1700026D08 gene 1.60 0.74 0.63 NM_001033176 1700039E15Rik RIKEN cDNA 1700039E15 gene 1.63 0.69 0.69 NM_026627 1700113O17Rik RIKEN cDNA 1700113O17 gene 1.43 0.75 0.65 NM_027239 1810065E05Rik RIKEN cDNA 1810065E05 gene 1.55 0.71 0.65 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 1.58 0.70 0.62 NM_027093 2310003L22Rik RIKEN cDNA 2310003L22 gene 1.54 0.66 0.65 NM_054100 2310034C09Rik RIKEN cDNA 2310034C09 gene 1.68 0.72 0.71 NM_027426 2610109H07Rik RIKEN cDNA 2610109H07 gene 1.50 0.68 0.64 NM_026048 2810452K22Rik RIKEN cDNA 2810452K22 gene 1.47 0.72 0.6 NM_175497 4732495G21Rik RIKEN cDNA 4732495G21 gene 1.46 0.73 0.67 NM_172450 4930539E08Rik RIKEN cDNA 4930539E08 gene 1.45 0.65 0.65 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 1.43 0.70 0.68 NM_172534 4932411E22Rik RIKEN cDNA 4932411E22 gene 1.42 0.74 0.63 NM_010667 5430421N21Rik RIKEN cDNA 5430421N21 gene 1.57 0.73 0.7 NM_001033776 7420416P09Rik RIKEN cDNA 7420416P09 gene 1.54 0.69 0.71 NM_026566 9430023L20Rik RIKEN cDNA 9430023L20 gene 1.43 0.74 0.71 NM_177787 9830102E05Rik RIKEN cDNA 9830102E05 gene 1.94 0.72 0.71 NM_183194 9930109F21Rik RIKEN cDNA 9930109F21 gene 1.41 0.71 0.6 NM_020591 A030009H04Rik RIKEN cDNA A030009H04 gene 1.66 0.76 0.7 Alpha 1,3-galactosyltransferase 2 NM_001009819 A3galt2 (isoglobotriaosylceramide synthase) 1.63 0.62 0.6 NM_177248 A630005I04Rik RIKEN cDNA A630005I04 gene 1.42 0.75 0.7 NM_175449 A630077B13Rik RIKEN cDNA A630077B13 gene 1.46 0.75 0.71 ABO blood group (transferase A, alpha 1- 3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3- NM_030718 Abo galactosyltransferase) 1.56 0.60 0.64 NM_178308 Abpg Androgen binding protein gamma 1.57 0.71 0.69 NM_025271 Actl7b Actin-like 7b 1.77 0.70 0.67 NM_033268 Actn2 Actinin alpha 2 1.51 0.72 0.67 NM_133883 Adprhl2 ADP-ribosylhydrolase like 2 1.65 0.73 0.71 AHA1, activator of heat shock protein NM_172391 Ahsa2 ATPase homolog 2 (yeast) 2.15 0.49 0.48 NM_177912 AI987692 Expressed sequence AI987692 1.49 0.73 0.63 NM_009654 Alb Albumin 1.55 0.73 0.64 NM_019871 Amac1 Acyl-malonyl condensing enzyme 1 1.44 0.68 0.68

229 Anillin, actin binding protein (scraps NM_028390 Anln homolog, Drosophila) 1.47 0.68 0.65 NM_172808 Antxrl Anthrax toxin receptor-like 1.57 0.73 0.63 NM_030255 Apobec3 Apolipoprotein B editing complex 3 1.60 0.72 0.6 NM_133996 Apon Apolipoprotein N 1.49 0.75 0.71 NM_175087 Aqp6 Aquaporin 6 1.49 0.73 0.59 NM_029270 Arhgap24 Rho GTPase activating protein 24 1.56 0.63 0.71 Rho guanine nucleotide exchange factor NM_177566 Arhgef15 (GEF) 15 1.46 0.67 0.71 ADP-ribosylation factor-like 2 binding NM_024191 Arl2bp protein 1.47 0.75 0.71 NM_026034 Armc10 Armadillo repeat containing 10 1.41 0.73 0.61 NM_019915 Art2b ADP-ribosyltransferase 2b 1.64 0.74 0.7 ATPase, H+/K+ exchanging, gastric, alpha NM_018731 Atp4a polypeptide 1.45 0.62 0.67 ATP synthase, H+ transporting, NM_007507 Atp5k mitochondrial F1F0 complex, subunit e 1.78 0.63 0.57 NM_028844 Aven Apoptosis, caspase activation inhibitor 1.69 0.60 0.56 NM_144832 BC017643 CDNA sequence BC017643 1.77 0.72 0.67 NM_001008549 BC043301 CDNA sequence BC043301 1.68 0.68 0.62 NM_010871 Birc1f Baculoviral IAP repeat-containing 1f 1.44 0.73 0.67 NM_020558 C1d Nuclear DNA binding protein 1.49 0.75 0.7 NM_016704 C6 Complement component 6 1.50 0.73 0.61 Complement component 8, alpha NM_146148 C8a polypeptide 1.45 0.74 0.71 NM_178721 Cadm2 Cell adhesion molecule 2 1.49 0.75 0.64 Capping protein (actin filament) muscle Z- NM_007605 Capza3 line, alpha 3 1.46 0.65 0.71 NM_009802 Car6 Carbonic anhydrase 6 1.55 0.75 0.64 Caspase recruitment domain family, NM_175362 Card11 member 11 1.65 0.71 0.58 NM_009810 Casp3 Caspase 3 1.76 0.59 0.66 NM_001012309 Ccdc55 Coiled-coil domain containing 55 1.42 0.74 0.55 NM_201372 Ccdc84 Coiled-coil domain containing 84 1.52 0.67 0.64 NM_207268 Ccdc87 Coiled-coil domain containing 87 1.67 0.72 0.65 NM_001013412 Ccl26l Chemokine (C-C motif) ligand 26-like 1.49 0.72 0.67 NM_172909 Cd163l1 CD163 molecule-like 1 1.48 0.69 0.71 NM_007639 Cd1d1 CD1d1 antigen 1.43 0.76 0.7 NM_007652 Cd59a CD59a antigen 1.61 0.58 0.64 NM_009855 Cd80 CD80 antigen 1.45 0.73 0.7 NM_025496 Cdrt4 CMT1A duplicated region transcript 4 1.76 0.60 0.57 NM_177150 Cenpt Centromere protein T 1.62 0.65 0.6 Carbohydrate (chondroitin 6/keratan) NM_016803 Chst3 sulfotransferase 3 1.45 0.73 0.68 NM_009899 Clca1 Chloride channel calcium activated 1 1.44 0.60 0.64 NM_001007223 Clec3a C-type lectin domain family 3, member a 1.56 0.70 0.61 NM_011802 Clpx Caseinolytic peptidase X (E.coli) 1.42 0.75 0.68 CKLF-like MARVEL transmembrane NM_153582 Cmtm4 domain containing 4 1.48 0.74 0.7 NM_001037865 Col28a1 Collagen, type XXVIII, alpha 1 1.48 0.74 0.61 NM_053071 Cox6c Cytochrome c oxidase, subunit VIc 1.75 0.64 0.63 NM_001039049 Cox8c Cytochrome c oxidase, subunit VIIIc 1.71 0.61 0.62 NM_153076 Crygn Crystallin, gamma N 1.47 0.72 0.67 NM_027874 Csnk1d Casein kinase 1, delta 1.57 0.67 0.7

230 Cytochrome P450, family 2, subfamily b, NM_009999 Cyp2b10 polypeptide 10 1.52 0.68 0.71 NM_016890 Dctn3 Dynactin 3 1.56 0.60 0.61 NM_016672 Ddc Dopa decarboxylase 1.60 0.71 0.64 NM_145157 Defb19 Defensin beta 19 1.52 0.71 0.6 Deafness, autosomal dominant 5 homolog NM_018769 Dfna5h (human) 1.46 0.72 0.71 NM_001024474 Diras2 DIRAS family, GTP-binding RAS-like 2 1.54 0.65 0.65 NM_007870 Dnase1l3 Deoxyribonuclease 1-like 3 1.46 0.72 0.63 NM_019957 Dnase2b Deoxyribonuclease II beta 1.41 0.68 0.64 NM_176913 Dpep2 Dipeptidase 2 1.55 0.71 0.71 NM_007888 Dvl2 Dishevelled 2, dsh homolog (Drosophila) 1.45 0.66 0.69 NM_175011 E330017A01Rik RIKEN cDNA E330017A01 gene 1.70 0.74 0.59 NM_139293 Ece2 Endothelin converting enzyme 2 1.47 0.69 0.66 NM_007904 Ednrb Endothelin receptor type B 1.47 0.70 0.68 NM_177593 EG210155 Predicted gene, EG210155 1.41 0.76 0.69 NM_177665 EG229862 Predicted gene, EG229862 1.63 0.68 0.52 NM_183320 EG331529 Predicted gene, EG331529 1.49 0.70 0.7 NM_198657 EG381438 Predicted gene, EG381438 1.82 0.61 0.68 NM_001004162 EG432436 Predicted gene, EG432436 1.47 0.72 0.65 NM_053207 Egln1 EGL nine homolog 1 (C. elegans) 1.43 0.64 0.63 Engulfment and cell motility 1, ced-12 NM_080288 Elmo1 homolog (C. elegans) 1.71 0.75 0.66 Engulfment and cell motility 2, ced-12 NM_080287 Elmo2 homolog (C. elegans) 1.47 0.71 0.68 NM_016885 Emcn Endomucin 1.54 0.75 0.71 NM_145506 Epb4.1l5 Erythrocyte protein band 4.1-like 5 1.59 0.67 0.51 Electron transferring flavoprotein, beta NM_026695 Etfb polypeptide 1.50 0.68 0.7 NM_016857 Exoc7 Exocyst complex component 7 1.42 0.73 0.7 NM_025923 Fancl Fanconi anemia, complementation group L 1.45 0.70 0.71 NM_001033669 Fbxw10 F-box and WD-40 domain protein 10 1.61 0.70 0.68 NM_175401 Fbxw17 F-box and WD-40 domain protein 17 1.45 0.73 0.67 NM_010190 Fcnb Ficolin B 1.59 0.68 0.7 NM_001029984 Fcrlb Fc receptor-like B 1.65 0.66 0.69 FYVE, RhoGEF and PH domain NM_015759 Fgd3 containing 3 1.51 0.68 0.63 NM_010197 Fgf1 Fibroblast growth factor 1 1.64 0.65 0.53 NM_019873 Fkbpl FK506 binding protein-like 1.54 0.70 0.7 NM_008239 Foxq1 Forkhead box Q1 1.48 0.65 0.63 GIPC PDZ domain containing family, NM_018771 Gipc1 member 1 1.46 0.67 0.64 Gap junction membrane channel protein NM_008123 Gja8 alpha 8 1.47 0.64 0.57 NM_019832 Gkap1 G kinase anchoring protein 1 1.44 0.74 0.61 NM_025467 Gkn2 Gastrokine 2 1.45 0.69 0.69 NM_001033473 Gm1157 Gene model 1157, (NCBI) 1.50 0.73 0.66 NM_001018031 Gm414 Gene model 414, (NCBI) 2.03 0.63 0.66 NM_001033252 Gm732 Gene model 732, (NCBI) 1.58 0.61 0.55 Glycoprotein 2 (zymogen granule NM_025989 Gp2 membrane) 1.80 0.62 0.53 NM_133776 Gpr110 G protein-coupled receptor 110 1.62 0.63 0.7 NM_001033493 Gpr111 G protein-coupled receptor 111 1.61 0.75 0.7 NM_001033498 Gramd2 GRAM domain containing 2 1.48 0.74 0.65

231 NM_008175 Grn Granulin 1.42 0.72 0.67 NM_025768 Grtp1 GH regulated TBC protein 1 1.48 0.75 0.69 NM_026764 Gstm4 Glutathione S-transferase, mu 4 1.55 0.75 0.68 NM_023630 Gtf2a1l General transcription factor IIA, 1-like 1.44 0.69 0.71 NM_008193 Guk1 Guanylate kinase 1 1.55 0.63 0.69 NM_177635 H2-M11 Histocompatibility 2, M region locus 11 1.50 0.68 0.67 NM_207225 Hdac4 Histone deacetylase 4 1.65 0.66 0.7 NM_013547 Hgd Homogentisate 1, 2-dioxygenase 1.65 0.71 0.61 NM_018792 Hils1 Histone H1-like protein in spermatids 1 1.46 0.67 0.71 NM_133871 Ifi44 Interferon-induced protein 44 1.47 0.68 0.58 NM_028078 Igsf5 Immunoglobulin superfamily, member 5 1.46 0.76 0.66 NM_010549 Il11ra1 Interleukin 11 receptor, alpha chain 1 1.47 0.64 0.55 NM_010551 Il16 Interleukin 16 1.57 0.60 0.71 NM_019450 Il1f6 Interleukin 1 family, member 6 1.49 0.73 0.69 NM_008362 Il1r1 Interleukin 1 receptor, type I 1.57 0.67 0.69 NM_010555 Il1r2 Interleukin 1 receptor, type II 1.55 0.75 0.66 NM_008364 Il1rap Interleukin 1 receptor accessory protein 1.48 0.68 0.69 NM_008386 Ins1 Insulin I 1.58 0.71 0.65 NM_010582 Itih2 Inter-alpha trypsin inhibitor, heavy chain 2 1.59 0.69 0.69 NM_173001 Jmjd1a Jumonji domain containing 1A 1.53 0.66 0.66 NM_030887 Jundm2 Jun dimerization protein 2 1.45 0.52 0.68 Potassium channel tetramerisation domain NM_001012434 Kctd14 containing 14 1.52 0.67 0.67 NM_010615 Kif11 Kinesin family member 11 1.43 0.73 0.7 NM_178771 Klhl26 Kelch-like 26 (Drosophila) 1.52 0.60 0.69 NM_174865 Klk15 Kallikrein related-peptidase 15 1.79 0.68 0.59 NM_010644 Klk1b26 Kallikrein 1-related petidase b26 1.45 0.64 0.71 Kallikrein related-peptidase 4 (prostase, NM_019928 Klk4 enamel matrix, prostate) 1.94 0.55 0.68 Killer cell lectin-like receptor subfamily C, NM_010653 Klrc2 member 2 1.49 0.66 0.66 NM_001039124 Kncn Kinocilin 1.65 0.72 0.62 NM_010665 Krt32 Keratin 32 1.70 0.66 0.62 NM_027563 Krt34 Keratin 34 1.44 0.75 0.62 NM_008475 Krt4 Keratin 4 1.48 0.73 0.67 NM_130870 Krtap16-1 Keratin associated protein 16-1 1.62 0.65 0.65 Similar to similar to testis expressed NM_001040089 LOC621852 homeobox 2 1.59 0.73 0.68 NM_029796 Lrg1 Leucine-rich alpha-2-glycoprotein 1 1.54 0.66 0.67 NM_010745 Ly86 Lymphocyte antigen 86 1.57 0.71 0.69 NM_001013802 Macrod2 MACRO domain containing 2 1.55 0.72 0.66 NM_020017 Magea3 Melanoma antigen, family A, 3 1.68 0.75 0.63 Membrane associated guanylate kinase, NM_015823 Magi2 WW and PDZ domain containing 2 1.46 0.68 0.71 Mitogen-activated protein kinase kinase NM_016896 Map3k14 kinase 14 1.43 0.76 0.69 Mediator of RNA polymerase II transcription, subunit 11 homolog (S. NM_025397 Med11 cerevisiae) 1.45 0.74 0.71 O-6-methylguanine-DNA NM_008598 Mgmt methyltransferase 1.59 0.60 0.51 NM_010798 Mif Macrophage migration inhibitory factor 1.44 0.75 0.67 Monocyte to macrophage differentiation- NM_026178 Mmd associated 1.59 0.68 0.67

232 Monocyte to macrophage differentiation- NM_175217 Mmd2 associated 2 1.49 0.75 0.65 NM_152944 Mmp21 Matrix metallopeptidase 21 1.50 0.67 0.69 NM_001033450 Mnda Myeloid cell nuclear differentiation antigen 1.53 0.66 0.64 NM_139296 Moxd2 Monooxygenase, DBH-like 2 1.51 0.72 0.69 Metallophosphoesterase domain containing NM_172610 Mpped1 1 1.79 0.65 0.68 NM_008669 Naga N-acetyl galactosaminidase, alpha 1.50 0.67 0.64 Non-SMC condensin II complex, subunit NM_133762 Ncapg2 G2 1.50 0.65 0.68 NADH dehydrogenase (ubiquinone) Fe-S NM_010887 Ndufs4 protein 4 1.57 0.72 0.6 NIMA (never in mitosis gene a)-related NM_011848 Nek3 expressed kinase 3 1.54 0.66 0.7 NM_016718 Ninj2 Ninjurin 2 1.47 0.71 0.67 Nudix (nucleoside diphosphate linked NM_026497 Nudt12 moiety X)-type motif 12 1.73 0.60 0.63 NM_010949 Numb Numb gene homolog (Drosophila) 1.71 0.62 0.57 NM_008750 Nxn Nucleoredoxin 1.48 0.62 0.64 NM_146762 Olfr1013 Olfactory receptor 1013 1.52 0.52 0.55 NM_146586 Olfr1018 Olfactory receptor 1018 1.49 0.70 0.64 NM_146985 Olfr1270 Olfactory receptor 1270 1.68 0.72 0.69 NM_146852 Olfr1339 Olfactory receptor 1339 1.46 0.74 0.71 NM_001011853 Olfr1425 Olfactory receptor 1425 1.80 0.68 0.66 NM_147068 Olfr166 Olfactory receptor 166 1.55 0.74 0.67 NM_146446 Olfr215 Olfactory receptor 215 1.52 0.72 0.65 NM_146721 Olfr424 Olfactory receptor 424 1.63 0.76 0.68 NM_146711 Olfr43 Olfactory receptor 43 1.57 0.73 0.62 NM_001011528 Olfr456 Olfactory receptor 456 1.48 0.74 0.71 NM_001011776 Olfr527 Olfactory receptor 527 1.60 0.73 0.66 NM_001011815 Olfr533 Olfactory receptor 533 1.65 0.71 0.67 NM_146520 Olfr536 Olfactory receptor 536 1.53 0.72 0.68 NM_146360 Olfr574 Olfactory receptor 574 1.76 0.63 0.64 NM_146315 Olfr62 Olfactory receptor 62 1.55 0.72 0.7 NM_147119 Olfr632 Olfactory receptor 632 1.45 0.67 0.69 NM_146820 Olfr655 Olfactory receptor 655 1.81 0.75 0.71 NM_146355 Olfr692 Olfactory receptor 692 1.48 0.71 0.56 NM_146931 Olfr796 Olfactory receptor 796 1.74 0.56 0.59 NM_146828 Olfr975 Olfactory receptor 975 1.74 0.65 0.61 NM_201258 Oog3 Oogenesin 3 1.46 0.71 0.71 Oxoglutarate (alpha-ketoglutarate) receptor NM_001001490 Oxgr1 1 1.65 0.67 0.68 NM_008791 Pcp4 Purkinje cell protein 4 1.46 0.73 0.65 NM_008797 Pcx Pyruvate carboxylase 1.44 0.67 0.56 NM_008811 Pdha2 Pyruvate dehydrogenase E1 alpha 2 1.56 0.74 0.44 NM_053191 Pi15 Peptidase inhibitor 15 1.60 0.68 0.7 NM_145131 Pitrm1 Pitrilysin metallepetidase 1 1.45 0.75 0.67 NM_029686 Pkd1l2 Polycystic kidney disease 1 like 2 1.43 0.70 0.7 NM_011107 Pla2g1b Phospholipase A2, group IB, pancreas 1.50 0.67 0.71 Pleckstrin homology domain containing, family A (phosphoinositide binding NM_133942 Plekha1 specific) member 1 1.42 0.76 0.7 NM_018874 Pnliprp1 Pancreatic lipase related protein 1 1.64 0.71 0.57 NM_027504 Prdm16 PR domain containing 16 1.49 0.75 0.61

233 NM_031191 Prl2c2 Prolactin family 2, subfamily c, member 2 1.56 0.64 0.61 NM_008865 Prl3b1 Prolactin family 3, subfamily b, member 1 1.44 0.74 0.65 NM_008936 Prop1 Paired like homeodomain factor 1 1.76 0.63 0.62 NM_028447 Prrc1 Proline-rich coiled-coil 1 1.57 0.71 0.61 NM_009430 Prss2 Protease, serine, 2 1.81 0.69 0.69 NM_133351 Prss8 Protease, serine, 8 (prostasin) 1.56 0.69 0.6 Pleckstrin homology, Sec7 and coiled/coil NM_028195 Pscd4 domains 4 1.61 0.72 0.7 NM_138580 Rdbp RD RNA-binding protein 1.56 0.65 0.68 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 1.56 0.73 0.64 NM_021300 Rhox4b Reproductive homeobox 4B 1.75 0.74 0.66 NM_201236 Rhox4e Reproductive homeobox 4E 1.51 0.75 0.7 NM_172521 RP23-336F11.32 Nuclear protein in testis 1.74 0.67 0.61 NM_001002239 Rpl17 Ribosomal protein L17 1.56 0.69 0.7 NM_011347 Selp Selectin, platelet 1.62 0.67 0.62 NM_029100 Sepn1 Selenoprotein N, 1 1.47 0.70 0.66 Serine (or cysteine) peptidase inhibitor, NM_009247 Serpina1e clade A, member 1e 1.44 0.72 0.71 NM_021372 Sertad2 SERTA domain containing 2 1.52 0.66 0.65 Soc-2 (suppressor of clear) homolog (C. NM_019658 Shoc2 elegans) 1.49 0.67 0.67 Sirtuin 2 (silent mating type information NM_022432 Sirt2 regulation 2, homolog) 2 (S. cerevisiae) 1.45 0.73 0.54 Solute carrier family 17 (sodium NM_177016 Slc17a4 phosphate), member 4 1.67 0.64 0.66 NM_177243 Slc26a9 Solute carrier family 26, member 9 1.60 0.64 0.67 Solute carrier family 34 (sodium NM_011392 Slc34a1 phosphate), member 1 1.77 0.59 0.61 Solute carrier family 35 (UDP-N- acetylglucosamine (UDP-GlcNAc) NM_144902 Slc35a3 transporter), member 3 1.71 0.70 0.66 NM_134060 Slc35b3 Solute carrier family 35, member B3 1.58 0.74 0.69 Solute carrier family 39 (zinc transporter), NM_001039676 Slc39a2 member 2 1.42 0.69 0.7 Solute carrier family 4 (anion exchanger), NM_011403 Slc4a1 member 1 1.41 0.69 0.58 Solute carrier organic anion transporter NM_033314 Slco2a1 family, member 2a1 1.43 0.66 0.69 SMEK homolog 1, suppressor of mek1 NM_211355 Smek1 (Dictyostelium) 1.43 0.71 0.7 NM_007706 Socs2 Suppressor of cytokine signaling 2 1.41 0.71 0.7 Spi-C transcription factor (Spi-1/PU.1 NM_011461 Spic related) 1.62 0.70 0.66 NM_183284 Spink2 Serine peptidase inhibitor, Kazal type 2 1.55 0.62 0.56 NM_011468 Sprr2a Small proline-rich protein 2A 1.70 0.72 0.66 NM_020611 Srd5a2l Steroid 5 alpha-reductase 2-like 1.52 0.71 0.69 Stress 70 protein chaperone, microsome- NM_030201 Stch associated, human homolog 1.76 0.73 0.59 SGT1, suppressor of G2 allele of SKP1 (S. NM_026474 Sugt1 cerevisiae) 1.72 0.60 0.53 NM_207021 Tas2r117 Taste receptor, type 2, member 117 2.38 0.42 0.44 NM_199159 Tas2r135 Taste receptor, type 2, member 135 1.56 0.67 0.66 NM_013773 Tcl1b1 T-cell leukemia/lymphoma 1B, 1 1.49 0.71 0.67 NM_009375 Tg Thyroglobulin 1.52 0.65 0.71 NM_028597 Thoc3 THO complex 3 1.61 0.71 0.56 Thyroid hormone receptor associated NM_146153 Thrap3 protein 3 1.44 0.72 0.65

234 NM_172476 Tmc7 Transmembrane channel-like gene family 7 1.47 0.66 0.68 NM_177735 Tmem130 Transmembrane protein 130 1.52 0.66 0.66 NM_153589 Tmem16b Transmembrane protein 16B 1.48 0.74 0.7 NM_144805 Tmem40 Transmembrane protein 40 1.68 0.71 0.51 NM_025693 Tmem41a Transmembrane protein 41a 1.59 0.64 0.52 Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry NM_178931 Tnfrsf14 mediator) 1.51 0.67 0.65 NM_009407 Tnp1 Transition protein 1 1.52 0.74 0.51 NM_031176 Tnxb Tenascin XB 1.55 0.68 0.62 NM_001024206 Trappc1 Trafficking protein particle complex 1 1.44 0.64 0.67 NM_001025599 Trim26 Tripartite motif protein 26 1.48 0.68 0.6 Ubiquitin associated and SH3 domain NM_177823 Ubash3a containing, A 1.65 0.69 0.58 UDP glucuronosyltransferase 1 family, NM_145079 Ugt1a7c polypeptide A7C 1.52 0.73 0.71 NM_134168 V1rc13 Vomeronasal 1 receptor, C13 1.46 0.74 0.71 NM_019780 Vps29 Vacuolar protein sorting 29 (S. pombe) 1.55 0.59 0.63 NM_138685 Wfdc15b WAP four-disulfide core domain 15B 1.45 0.74 0.7 NM_018791 Zfp108 Zinc finger protein 108 1.47 0.66 0.68 NM_028913 Zfp819 Zinc finger protein 819 1.56 0.69 0.59 NM_001001130 Zfp85-rs1 Zinc finger protein 85, related sequence 1 1.66 0.72 0.67 NM_001033195 1.92 0.73 0.63 NM_183120 1.43 0.76 0.64 NM_001001987 1.45 0.73 0.67 NM_001024470 1.78 0.69 0.67 NM_026461 1.53 0.73 0.69 NM_001013752 1.59 0.71 0.7 NM_001013781 1.68 0.68 0.7 NM_028045 1.46 0.69 0.7

SUPPLEMENTAL TABLE S23: Genes Demonstrating Reversal of Decreased Phospho-CREB Binding by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

Defeat Fold Resiliency Fold Imipramine Fold Accession Number Symbol Name Change Change Change NM_024172 1500019G21Rik RIKEN cDNA 1500019G21 gene 0.30 3.34 3.18 NM_025929 2010109I03Rik RIKEN cDNA 2010109I03 gene 0.42 2.62 2.17 NM_025591 2010309E21Rik RIKEN cDNA 2010309E21 gene 0.42 2.67 2.22 NM_027977 2310001A20Rik RIKEN cDNA 2310001A20 gene 0.34 2.73 6.57 NM_026511 2810002N01Rik RIKEN cDNA 2810002N01 gene 0.41 2.85 2.44 NM_028377 2900006K08Rik RIKEN cDNA 2900006K08 gene 0.36 3.06 2.32 NM_172698 4732418C07Rik RIKEN cDNA 4732418C07 gene 0.39 3.07 2.03 NM_207527 4930504O13Rik RIKEN cDNA 4930504O13 gene 0.39 3.26 2.58 NM_198607 4930572J05Rik RIKEN cDNA 4930572J05 gene 0.41 3.20 2.21 NM_177230 4932413O14Rik RIKEN cDNA 4932413O14 gene 0.38 2.63 2.23 NM_027478 5730494N06Rik RIKEN cDNA 5730494N06 gene 0.28 3.57 3.51 NM_029960 9230104L09Rik RIKEN cDNA 9230104L09 gene 0.35 3.62 2.74 NM_212473 A930008G19Rik RIKEN cDNA A930008G19 gene 0.24 3.96 2.11 ATP-binding cassette, sub-family A NM_177213 Abca15 (ABC1), member 15 0.39 2.97 3.10 ATP-binding cassette, sub-family F NM_013854 Abcf1 (GCN20), member 1 0.38 3.15 2.88

235 Acyl-Coenzyme A binding domain NM_025988 Acbd4 containing 4 0.27 2.90 2.71 NM_025271 Actl7b Actin-like 7b 0.43 3.02 2.60 Aldhehyde dehydrogenase family 5, NM_172532 Aldh5a1 subfamily A1 0.37 3.30 2.43 NM_198027 Alkbh6 AlkB, alkylation repair homolog 6 (E. coli) 0.18 2.56 2.42 NM_033603 Amn Amnionless 0.43 3.05 2.18 NM_026904 Anapc10 Anaphase promoting complex subunit 10 0.38 2.53 2.31 NM_027480 Ankrd24 Ankyrin repeat domain 24 0.29 2.76 2.30 Acidic (leucine-rich) nuclear phosphoprotein NM_023210 Anp32e 32 family, member E 0.43 4.07 2.80 NM_145425 AV249152 Expressed sequence AV249152 0.35 2.80 2.01 NM_177632 BC022623 CDNA sequence BC022623 0.45 2.83 2.86 NM_153557 BC029214 CDNA sequence BC029214 0.44 3.38 2.48 NM_009754 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.42 3.38 2.28 NM_009764 Brca1 Breast cancer 1 0.40 2.69 2.81 Budding uninhibited by benzimidazoles 1 NM_009773 Bub1b homolog, beta (S. cerevisiae) 0.36 2.51 2.03 NM_001008705 Bud31 BUD31 homolog (yeast) 0.27 2.72 2.20 NM_175696 C530028O21Rik RIKEN cDNA C530028O21 gene 0.43 3.55 2.04 Calcium channel, voltage-dependent, L type, NM_009781 Cacna1c alpha 1C subunit 0.41 2.77 2.74 Calcium channel, voltage-dependent, gamma NM_019430 Cacng3 subunit 3 0.37 2.93 2.02 NM_007586 Calb2 Calbindin 2 0.23 3.24 7.20 NM_145595 Cbr4 Carbonyl reductase 4 0.42 3.15 3.24 NM_026964 Ccdc124 Coiled-coil domain containing 124 0.36 2.76 2.67 NM_175430 Ccdc40 Coiled-coil domain containing 40 0.37 9.48 3.65 NM_023731 Ccdc86 Coiled-coil domain containing 86 0.26 3.18 2.07 NM_009853 Cd68 CD68 antigen 0.38 5.93 3.00 NM_026373 Cdk2ap2 CDK2-associated protein 2 0.33 3.72 2.20 NM_133960 Ces6 Carboxylesterase 6 0.45 2.90 2.27 NM_007691 Chek1 Checkpoint kinase 1 homolog (S. pombe) 0.36 4.42 2.26 NM_026885 Chmp2a Chromatin modifying protein 2A 0.40 3.34 1.97 NM_133724 Cno Cappuccino 0.40 3.21 2.64 NM_019817 Copz1 Coatomer protein complex, subunit zeta 1 0.28 4.59 2.07 NM_001024926 Cyb5d2 Cytochrome b5 domain containing 2 0.23 2.88 2.90 DNA segment, Chr 6, Wayne State NM_138594 D6Wsu163e University 163, expressed 0.45 4.90 2.95 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_026538 Ddx56 56 0.45 3.51 2.30 NM_145157 Defb19 Defensin beta 19 0.41 6.21 3.25 NM_026082 Dock7 Dedicator of cytokinesis 7 0.43 2.57 1.99 NM_176913 Dpep2 Dipeptidase 2 0.38 4.07 2.13 NM_027193 Dph5 DPH5 homolog (S. cerevisiae) 0.42 3.15 2.09 NM_001034909 EG547347 Predicted gene, EG547347 0.40 2.58 1.95 NM_007924 Ell Elongation factor RNA polymerase II 0.24 3.88 2.35 Enhancer of rudimentary homolog NM_007951 Erh (Drosophila) 0.28 3.42 2.05 Electron transferring flavoprotein, beta NM_026695 Etfb polypeptide 0.26 3.84 2.19 NM_019873 Fkbpl FK506 binding protein-like 0.41 4.10 2.30 NM_021899 Foxj2 Forkhead box J2 0.43 3.06 2.27 NM_033320 Glce Glucuronyl C5-epimerase 0.39 3.42 3.03

236 NM_153394 Gpr156 G protein-coupled receptor 156 0.15 3.11 2.09 NM_010360 Gstm5 Glutathione S-transferase, mu 5 0.37 2.99 1.98 NM_198962 Hcrtr2 Hypocretin (orexin) receptor 2 0.42 3.34 3.21 NM_001033432 Heca Headcase homolog (Drosophila) 0.41 3.01 2.01 3-hydroxymethyl-3-methylglutaryl- NM_173731 Hmgcll1 Coenzyme A lyase-like 1 0.44 2.51 2.33 Intraflagellar transport 122 homolog NM_031177 Ift122 (Chlamydomonas) 0.37 3.37 2.75 Intraflagellar transport 140 homolog NM_134126 Ift140 (Chlamydomonas) 0.35 3.25 2.22 NM_001033323 Igsf9b Immunoglobulin superfamily, member 9B 0.37 3.24 2.11 Potassium voltage-gated channel, Isk-related NM_008424 Kcne1 subfamily, member 1 0.34 3.92 2.05 Potassium channel tetramerisation domain NM_134073 Kctd9 containing 9 0.40 3.03 1.98 NM_010673 Krtap6-2 Keratin associated protein 6-2 0.38 3.00 2.09 NM_010702 Lect2 Leukocyte cell-derived chemotaxin 2 0.41 4.20 2.59 NM_026719 Lmbrd1 LMBR1 domain containing 1 0.42 2.75 2.11 NM_033325 Loxl2 Lysyl oxidase-like 2 0.37 3.17 2.74 Major facilitator superfamily domain NM_029662 Mfsd2 containing 2 0.20 3.37 3.08 NM_019944 Mnx1 Motor neuron and pancreas homeobox 1 0.31 3.80 3.80 NM_025606 Mrpl16 Mitochondrial ribosomal protein L16 0.37 3.94 2.45 NM_023166 Mtvr2 Mammary tumor virus receptor 2 0.33 4.17 3.09 NM_013605 Muc1 Mucin 1, transmembrane 0.34 2.54 2.16 NM_153529 Nrn1 Neuritin 1 0.40 3.21 2.79 NM_016773 Nucb2 Nucleobindin 2 0.24 3.27 2.21 Nudix (nucleoside diphosphate linked NM_008637 Nudt1 moiety X)-type motif 1 0.31 3.11 2.05 NM_146573 Olfr1002 Olfactory receptor 1002 0.45 2.56 2.02 NM_146283 Olfr1366 Olfactory receptor 1366 0.19 3.30 2.56 NM_001011741 Olfr1386 Olfactory receptor 1386 0.37 2.53 2.77 NM_020598 Olfr17 Olfactory receptor 17 0.42 3.88 2.05 NM_147041 Olfr57 Olfactory receptor 57 0.35 4.89 2.23 NM_001003717 Osbpl8 Oxysterol binding protein-like 8 0.45 4.12 3.03 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, NM_025939 Paics succinocarboxamide synthetase 0.36 3.58 2.53 NM_008782 Pax5 Paired box gene 5 0.37 6.68 3.16 NM_009545 Pcgf2 Polycomb group ring finger 2 0.41 3.53 2.57 NM_026850 Pdcl3 Phosducin-like 3 0.45 2.84 2.24 NM_011070 Pfdn2 Prefoldin 2 0.40 2.83 2.83 NM_001039509 Pnkd Paroxysmal nonkinesiogenic dyskinesia 0.42 2.96 1.96 NM_145145 Pomt1 Protein-O-mannosyltransferase 1 0.44 4.26 2.51 NM_175363 Pphln1 Periphilin 1 0.40 2.58 2.32 Protein phosphatase 1, regulatory (inhibitor) NM_138605 Ppp1r3f subunit 3F 0.45 2.67 2.89 Protein phosphatase 3, regulatory subunit B, NM_024459 Ppp3r1 alpha isoform (calcineurin B, type I) 0.35 2.83 2.14 NM_025596 Prelid1 PRELI domain containing 1 0.34 3.14 2.14 NM_008925 Prkcsh Protein kinase C substrate 80K-H 0.37 3.69 3.33 NM_080436 Rdh1 Retinol dehydrogenase 1 (all trans) 0.32 3.08 2.10 Retinol dehydrogenase 13 (all-trans and 9- NM_175372 Rdh13 cis) 0.45 2.76 2.28 NM_027445 Rnf167 Ring finger protein 167 0.43 3.24 2.07

237 NM_023133 Rps19 Ribosomal protein S19 0.30 3.39 1.99 RNA pseudouridylate synthase domain NM_173450 Rpusd2 containing 2 0.42 2.74 2.41 NM_130892 Rtn4ip1 Reticulon 4 interacting protein 1 0.45 2.66 3.18 NM_009115 S100b S100 protein, beta polypeptide, neural 0.34 3.03 2.46 NM_013928 Schip1 Schwannomin interacting protein 1 0.42 3.60 2.25 Solute carrier family 30 (zinc transporter), NM_011773 Slc30a3 member 3 0.40 2.96 2.07 Solute carrier family 37 (glycerol-3- NM_153062 Slc37a1 phosphate transporter), member 1 0.41 2.70 2.39 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily NM_011416 Smarca2 a, member 2 0.38 3.26 3.00 SWI/SNF-related, matrix-associated actin- dependent regulator of chromatin, subfamily NM_007958 Smarcad1 a, containing DEAD/H box 1` 0.45 4.36 2.92 NM_001025612 Snx22 Sorting nexin 22 0.35 2.78 2.14 NM_009238 Sox4 SRY-box containing gene 4 0.42 2.71 2.43 NM_031183 Sp6 Trans-acting transcription factor 6 0.42 2.98 2.64 Signal peptidase complex subunit 2 homolog NM_025668 Spcs2 (S. cerevisiae) 0.38 3.35 2.32 Spi-C transcription factor (Spi-1/PU.1 NM_011461 Spic related) 0.36 2.91 3.03 Spondin 1, (f-spondin) extracellular matrix NM_145584 Spon1 protein 0.38 2.65 2.20 NM_020493 Srf Serum response factor 0.43 3.17 2.30 Suppressor of variegation 4-20 homolog 2 NM_146177 Suv420h2 (Drosophila) 0.26 2.89 2.65 NM_181516 Taz Tafazzin 0.41 2.91 2.93 Transcription elongation factor B (SIII), NM_026456 Tceb1 polypeptide 1 0.35 3.37 2.08 NM_153552 Thoc1 THO complex 1 0.37 3.18 2.24 NM_029649 Tmem101 Transmembrane protein 101 0.37 5.25 3.44 NM_001033393 Tmem104 Transmembrane protein 104 0.35 3.12 2.03 NM_133706 Tmem97 Transmembrane protein 97 0.39 3.01 2.13 NM_016788 Tnk2 Tyrosine kinase, non-receptor, 2 0.25 3.66 2.01 Translocase of outer mitochondrial NM_016871 Tomm40 membrane 40 homolog (yeast) 0.32 2.65 2.17 Topoisomerase I binding, arginine/serine- NM_134097 Topors rich 0.43 2.57 2.12 NM_001024206 Trappc1 Trafficking protein particle complex 1 0.26 3.04 2.02 NM_029979 Trim35 Tripartite motif-containing 35 0.42 5.08 2.47 Transformation related protein 53 inducible NM_178111 Trp53inp2 nuclear protein 2 0.36 2.70 2.26 NM_018879 Tusc4 Tumor suppressor candidate 4 0.29 4.65 2.31 NM_146144 Usp1 Ubiquitin specific peptdiase 1 0.44 3.67 2.99 NM_178635 Uvrag UV radiation resistance associated gene 0.40 4.94 2.76 Valosin containing protein (p97)/p47 NM_173443 Vcpip1 complex interacting protein 1 0.43 4.34 1.99 Ventricular zone expressed PH domain NM_145820 Veph1 homolog 1 (zebrafish) 0.32 2.68 2.27 NM_172470 Wdr35 WD repeat domain 35 0.42 4.00 2.92 NM_001025375 Wdr61 WD repeat domain 61 0.28 2.94 2.51 X-prolyl aminopeptidase (aminopeptidase P) NM_177310 Xpnpep3 3, putative 0.24 3.30 3.03 NM_026846 Zfand2b Zinc finger, AN1 type domain 2B 0.35 2.82 2.21 NM_001001186 Zfp456 Zinc finger protein 456 0.42 2.98 2.10

238 NM_144523 Zfp622 Zinc finger protein 622 0.28 3.55 3.24 NM_028913 Zfp819 Zinc finger protein 819 0.43 3.14 2.03 NM_027681 0.45 4.57 2.09 NM_001040398 0.35 3.40 2.36 NM_028793 0.24 3.91 3.30 NM_025472 0.36 3.50 3.35 NM_026297 0.22 3.37 4.14

SUPPLEMENTAL TABLE S24: Genes Demonstrating Reversal of Increased Phospho-CREB Binding by Imipramine and by Resiliency in the Social Defeat Model (p<0.001)

Defeat Fold Resiliency Fold Imipramine Fold Accession Numner Symbol Name Change Change Change NM_025946 2010100O12Rik RIKEN cDNA 2010100O12 gene 2.47 0.33 0.50 NM_001025573 2010107G12Rik RIKEN cDNA 2010107G12 gene 2.68 0.38 0.44 NM_172398 2310005E10Rik RIKEN cDNA 2310005E10 gene 2.26 0.30 0.49 NM_025865 2310030G06Rik RIKEN cDNA 2310030G06 gene 2.13 0.34 0.42 NM_026643 2410017P07Rik RIKEN cDNA 2410017P07 gene 2.32 0.29 0.35 NM_183287 2610318N02Rik RIKEN cDNA 2610318N02 gene 2.29 0.34 0.50 NM_027568 4733401H21Rik RIKEN cDNA 4733401H21 gene 2.91 0.33 0.41 NM_178388 4930425N13Rik RIKEN cDNA 4930425N13 gene 2.33 0.29 0.37 NM_026358 4930583H14Rik RIKEN cDNA 4930583H14 gene 3.86 0.36 0.29 NM_025744 4933404M02Rik RIKEN cDNA 4933404M02 gene 2.50 0.32 0.44 NM_177314 5330439B14Rik RIKEN cDNA 5330439B14 gene 2.59 0.39 0.48 NM_146091 5730596K20Rik RIKEN cDNA 5730596K20 gene 2.54 0.38 0.49 NM_001039720 9030619P08Rik RIKEN cDNA 9030619P08 gene 2.87 0.38 0.36 NM_175687 A230050P20Rik RIKEN cDNA A230050P20 gene 2.22 0.35 0.49 NM_080633 Aco2 Aconitase 2, mitochondrial 2.17 0.33 0.47 NM_013455 Acr Preproacrosin 2.53 0.27 0.30 A disintegrin and metallopeptidase NM_007402 Adam7 domain 7 2.58 0.34 0.44 Alcohol dehydrogenase 7 (class IV), mu NM_009626 Adh7 or sigma polypeptide 3.03 0.36 0.47 NM_173016 AI427515 Expressed sequence AI427515 2.41 0.36 0.44 NM_144903 Aldob Aldolase 2, B isoform 2.73 0.29 0.38 NM_178655 Ank2 Ankyrin 2, brain 2.17 0.35 0.48 NM_182994 Arl5a ADP-ribosylation factor-like 5A 2.11 0.38 0.42 NM_194347 AY358078 CDNA sequence AY358078 2.19 0.36 0.44 NM_080640 Baalc Brain and acute leukemia, cytoplasmic 2.56 0.36 0.48 NM_178446 BC013481 CDNA sequence BC013481 3.19 0.25 0.36 NM_146215 BC025546 CDNA sequence BC025546 2.30 0.26 0.32 NM_001033001 BC065397 CDNA sequence BC065397 2.88 0.32 0.35 NM_080708 Bmp2k BMP2 inducible kinase 2.13 0.38 0.46 NM_138678 Butr1 Butyrophilin related 1 2.58 0.35 0.37 NM_028296 Car10 Carbonic anhydrase 10 3.02 0.34 0.46 NM_007617 Cav3 Caveolin 3 2.36 0.38 0.42 NM_001033654 Ccdc139 Coiled-coil domain containing 139 3.09 0.30 0.38 NM_201372 Ccdc84 Coiled-coil domain containing 84 2.73 0.25 0.38 NM_172405 Ccdc98 Coiled-coil domain containing 98 2.11 0.27 0.31 NM_011333 Ccl2 Chemokine (C-C motif) ligand 2 2.49 0.34 0.39 CDC16 cell division cycle 16 homolog NM_027276 Cdc16 (S. cerevisiae) 2.25 0.33 0.39

239 Cyclin-dependent kinase inhibitor 2C NM_007671 Cdkn2c (p18, inhibits CDK4) 2.60 0.36 0.51 NM_018818 Chm Choroidermia 2.12 0.34 0.45 NM_029633 Clasp2 CLIP associating protein 2 2.27 0.30 0.33 NM_028798 Crct1 Cysteine-rich C-terminal 1 2.81 0.38 0.43 NM_028288 Cul4b Cullin 4B 3.81 0.24 0.26 Cytochrome P450, family 2, subfamily r, NM_177382 Cyp2r1 polypeptide 1 2.15 0.38 0.49 Cytochrome P450, family 4, subfamily f, NM_177307 Cyp4f39 polypeptide 39 3.23 0.34 0.32 NM_027030 Dcps Decapping enzyme, scavenger 2.27 0.32 0.30 DEAD (Asp-Glu-Ala-Asp) box NM_010029 Ddx4 polypeptide 4 4.49 0.21 0.23 NM_007843 Defb1 Defensin beta 1 2.68 0.37 0.39 NM_001034910 Defb42 Defensin beta 42 2.25 0.35 0.50 NM_001025296 Dffa DNA fragmentation factor, alpha subunit 2.79 0.36 0.43 NM_001025947 Dnm1l Dynamin 1-like 2.88 0.27 0.31 NM_001039556 E130016E03Rik RIKEN cDNA E130016E03 gene 2.46 0.38 0.51 NM_001034898 E530011F12Rik RIKEN cDNA E530011F12 gene 2.50 0.28 0.32 NM_172504 EG212225 Predicted gene, EG212225 2.25 0.30 0.39 NM_010135 Enah Enabled homolog (Drosophila) 2.46 0.38 0.40 NM_027123 Fastkd3 FAST kinase domains 3 2.16 0.34 0.42 NM_175530 Fbxo46 F-box protein 46 2.72 0.36 0.44 NM_019873 Fkbpl FK506 binding protein-like 2.24 0.42 NM_019873 Fkbpl FK506 binding protein-like 2.24 0.38 0.42 NM_144878 Fmo4 Flavin containing monooxygenase 4 2.31 0.35 0.47 NM_028407 Gcap14 Granule cell antiserum positive 14 2.20 0.35 0.50 Gap junction membrane channel protein NM_008123 Gja8 alpha 8 3.46 0.22 0.32 Guanine nucleotide binding protein, alpha NM_008141 Gnat2 transducing 2 2.48 0.36 0.44 Guanine nucleotide binding protein (G protein), gamma transducing activity NM_010314 Gngt1 polypeptide 1 2.89 0.22 0.42 NM_001035122 Golm1 Golgi membrane protein 1 2.43 0.29 0.31 Glutamate receptor, ionotropic, NM_008172 Grin2d NMDA2D (epsilon 4) 2.57 0.37 0.49 NM_010360 Gstm5 Glutathione S-transferase, mu 5 2.77 0.33 0.38 NM_008178 Gsx1 GS homeobox 1 3.94 0.31 0.30 NM_133256 Gsx2 GS homeobox 2 2.43 0.34 0.49 General transcription factor IIF, NM_026816 Gtf2f2 polypeptide 2 2.16 0.28 0.35 NM_144835 Heatr1 HEAT repeat containing 1 2.41 0.38 0.44 Homeodomain interacting protein kinase NM_010432 Hipk1 1 2.58 0.33 0.42 NM_023422 Hist1h2bc Histone cluster 1, H2bc 2.82 0.25 0.34 Hydroxy-delta-5-steroid dehydrogenase, NM_008295 Hsd3b5 3 beta- and steroid delta-isomerase 5 3.00 0.32 0.40 NM_028957 Hyal5 Hyaluronoglucosaminidase 5 2.30 0.24 0.29 NM_011940 Ifi202b Interferon activated gene 202B 2.89 0.32 0.47 Insulin-like growth factor 2 mRNA NM_183029 Igf2bp2 binding protein 2 2.46 0.29 0.42 NM_008366 Il2 Interleukin 2 2.89 0.30 0.40 NM_013563 Il2rg Interleukin 2 receptor, gamma chain 4.24 0.31 0.25 NM_008370 Il5ra Interleukin 5 receptor, alpha 4.09 0.35 0.37

240 NM_027927 Ints12 Integrator complex subunit 12 2.44 0.38 0.47 NM_011365 Itsn2 Intersectin 2 2.36 0.27 0.38 Potassium voltage-gated channel, NM_172805 Kcnh5 subfamily H (eag-related), member 5 5.27 0.29 0.38 Potassium channel tetramerisation NM_001012434 Kctd14 domain containing 14 4.54 0.25 0.23 NM_010629 Kifap3 Kinesin-associated protein 3 4.02 0.16 0.21 Killer cell lectin-like receptor, subfamily NM_010648 Klra3 A, member 3 2.14 0.30 0.44 Killer cell lectin-like receptor subfamily NM_008526 Klrb1d B member 1D 5.09 0.29 0.31 NM_001039666 Krt40 Keratin 40 2.29 0.36 0.42 NM_010695 Lcn4 Lipocalin 4 2.56 0.38 0.43 NM_026719 Lmbrd1 LMBR1 domain containing 1 3.21 0.24 0.34 NM_177178 Lmbrd2 LMBR1 domain containing 2 2.54 0.38 0.46 NM_207222 Lmo3 LIM domain only 3 2.38 0.37 0.44 NM_022882 Lpin2 Lipin 2 2.42 0.21 0.38 NM_178725 Lrrc4c Leucine rich repeat containing 4C 2.82 0.35 0.39 NM_133688 Lyrm5 LYR motif containing 5 2.14 0.31 0.36 NM_017372 Lyzs Lysozyme 2.20 0.36 0.36 NM_011839 Mab21l2 Mab-21-like 2 (C. elegans) 2.70 0.37 0.48 NM_175296 Mael Maelstrom homolog (Drosophila) 2.18 0.32 0.46 NM_134012 Mbtd1 Mbt domain containing 1 2.36 0.37 0.30 Minichromosome maintenance deficient 3 NM_008563 Mcm3 (S. cerevisiae) 2.51 0.29 0.37 NM_001039214 Mex3c Mex3 homolog C (C. elegans) 2.82 0.25 0.22 O-6-methylguanine-DNA NM_008598 Mgmt methyltransferase 2.34 0.30 0.41 NM_011746 Mkrn3 Makorin, ring finger protein, 3 2.35 0.26 0.29 NM_013826 Mocs2 Molybdenum cofactor synthesis 2 2.65 0.33 0.45 Mdm2, transformed 3T3 cell double NM_134092 Mtbp minute p53 binding protein 2.16 0.30 0.31 Mitochondrial methionyl-tRNA NM_027134 Mtfmt formyltransferase 3.03 0.24 0.20 NM_028860 Mtmr3 Myotubularin related protein 3 2.65 0.30 0.28 Alpha-N-acetylglucosaminidase NM_013792 Naglu (Sanfilippo disease IIIB) 2.44 0.34 0.40 NM_153126 Nat10 N-acetyltransferase 10 2.17 0.24 0.38 N-acetyltransferase 2 (arylamine N- NM_010874 Nat2 acetyltransferase) 2.78 0.35 0.43 NADH dehydrogenase (ubiquinone) 1 NM_023172 Ndufb9 beta subcomplex, 9 3.59 0.23 0.29 NM_025424 Nenf Neuron derived neurotrophic factor 2.41 0.31 0.44 Nuclear factor of activated T-cells, NM_010901 Nfatc3 cytoplasmic, calcineurin-dependent 3 3.33 0.38 0.50 Nurim (nuclear envelope membrane NM_134122 Nrm protein) 2.55 0.34 0.43 Non-SMC element 1 homolog (S. NM_026330 Nsmce1 cerevisiae) 2.18 0.35 0.51 NM_026004 Nt5c3 5'-nucleotidase, cytosolic III 2.20 0.34 0.36 Nuclear undecaprenyl pyrophosphate NM_030250 Nus1 synthase 1 homolog (S. cerevisiae) 2.20 0.38 0.43 NM_146921 Olfr1 Olfactory receptor 1 2.56 0.35 0.48 NM_146753 Olfr1195 Olfactory receptor 1195 2.25 0.35 0.50 NM_146794 Olfr1263 Olfactory receptor 1263 2.27 0.33 0.44 NM_146404 Olfr1289 Olfactory receptor 1289 4.97 0.20 0.25 NM_146403 Olfr1295 Olfactory receptor 1295 2.93 0.34 0.39

241 NM_146362 Olfr1312 Olfactory receptor 1312 2.15 0.33 0.41 NM_001011778 Olfr257 Olfactory receptor 257 2.37 0.32 0.37 NM_147036 Olfr283 Olfactory receptor 283 2.52 0.26 0.35 NM_001011863 Olfr406 Olfactory receptor 406 2.87 0.27 0.34 NM_001011528 Olfr456 Olfactory receptor 456 2.13 0.38 0.50 NM_001001805 Olfr576 Olfactory receptor 576 3.63 0.32 0.42 NM_147115 Olfr578 Olfactory receptor 578 3.26 0.24 0.35 NM_205822 Omt2b Oocyte maturation, beta 2.39 0.34 0.50 NM_198661 Oog2 Oogenesin 2 2.48 0.23 0.30 Oxidative stress induced growth inhibitor NM_027950 Osgin1 1 2.78 0.23 0.27

NM_001025244 OTTMUSG00000002177 Predicted gene, OTTMUSG00000002177 2.17 0.31 0.44

NM_177865 OTTMUSG00000008540 Predicted gene, OTTMUSG00000008540 2.84 0.37 0.48 Poly (ADP-ribose) polymerase family, NM_177460 Parp16 member 16 2.15 0.34 0.38 Poly (ADP-ribose) polymerase family, NM_030253 Parp9 member 9 2.31 0.31 0.49 NM_011067 Per3 Period homolog 3 (Drosophila) 2.68 0.38 0.50 NM_029293 Phpt1 Phosphohistidine phosphatase 1 2.94 0.35 0.34 Putative homeodomain transcription NM_172992 Phtf2 factor 2 2.59 0.32 0.46 Phosphatidylinositol 3-kinase, C2 domain NM_011084 Pik3c2g containing, gamma polypeptide 2.17 0.35 0.44 NM_013631 Pklr Pyruvate kinase liver and red blood cell 2.57 0.34 0.34 NM_011099 Pkm2 Pyruvate kinase, muscle 2.39 0.36 0.45 PR domain containing 1, with ZNF NM_007548 Prdm1 domain 2.49 0.38 0.48 NM_011174 Prh1 Proline rich protein HaeIII subfamily 1 2.89 0.26 0.34 NM_031499 Prh1 Proline rich protein HaeIII subfamily 1 2.81 0.35 0.43 NM_008926 Prkg2 Protein kinase, cGMP-dependent, type II 2.11 0.31 0.48 Prolactin family 2, subfamily c, member NM_031191 Prl2c2 2 2.21 0.36 0.43 Prolactin family 7, subfamily a, member NM_011168 Prl7a2 2 2.26 0.37 0.45 Prolactin family 7, subfamily d, member NM_011120 Prl7d1 1 2.58 0.39 0.47 NM_008937 Prox1 Prospero-related homeobox 1 2.79 0.30 0.50 NM_008941 Prss7 Protease, serine, 7 (enterokinase) 2.12 0.36 0.45 Proteasome (prosome, macropain) NM_011966 Psma4 subunit, alpha type 4 2.89 0.35 0.39 Protein tyrosine phosphatase, non- NM_011877 Ptpn21 receptor type 21 2.55 0.29 0.29 RAB11 family interacting protein 2 (class NM_001033172 Rab11fip2 I) 2.34 0.29 0.44 Ribonuclease, RNase A family, 11 (non- NM_001011877 Rnase11 active) 2.12 0.33 0.43 NM_033604 Rnf111 Ring finger 111 3.15 0.34 0.35 NM_019642 Rpn2 Ribophorin II 2.64 0.28 0.32 NM_001013376 Rpp38 Ribonuclease P/MRP 38 subunit (human) 2.82 0.29 0.38 NM_199422 S100a7a S100 calcium binding protein A7A 2.22 0.35 0.49 NM_020483 Sap30bp SAP30 binding protein 2.53 0.27 0.31 NM_007644 Scarb2 Scavenger receptor class B, member 2 3.45 0.33 0.41 NM_013883 Scmh1 Sex comb on midleg homolog 1 2.27 0.33 0.40 NM_012009 Sh2d1b1 SH2 domain protein 1B1 2.24 0.34 0.50 NM_172937 Shprh SNF2 histone linker PHD RING helicase 2.30 0.31 0.43

242 Sirtuin 2 (silent mating type information NM_022432 Sirt2 regulation 2, homolog) 2 (S. cerevisiae) 8.61 0.38 0.30 Sine oculis-related homeobox 6 homolog NM_011384 Six6 (Drosophila) 2.42 0.29 0.41 Solute carrier family 7 (cationic amino NM_007515 Slc7a3 acid transporter, y+ system), member 3 2.24 0.32 0.39 Solute carrier family 9 (sodium/hydrogen NM_177353 Slc9a7 exchanger), isoform 7 2.42 0.36 0.50 NM_029273 Slitrk5 SLIT and NTRK-like family, member 5 2.41 0.34 0.48 NM_176996 Smo Smoothened homolog (Drosophila) 2.34 0.36 0.46 NM_013669 Snap91 Synaptosomal-associated protein 91 2.24 0.35 0.43 NM_172926 Snx14 Sorting nexin 14 2.17 0.33 0.41 Spermatogenesis and centriole associated NM_028852 Spatc1 1 2.24 0.37 0.37 NM_182990 Ssrp1 Structure specific recognition protein 1 2.18 0.27 0.30 NM_178749 Stk32a Serine/threonine kinase 32A 2.13 0.37 0.46 NM_172294 Sulf1 Sulfatase 1 2.69 0.36 0.48 NM_016771 Sult1d1 Sulfotransferase family 1D, member 1 2.18 0.33 0.48 Suppressor of variegation 3-9 homolog 2 NM_022724 Suv39h2 (Drosophila) 2.22 0.32 0.39 NM_028052 Synpr Synaptoporin 4.23 0.30 0.39 NM_207029 Tas2r129 Taste receptor, type 2, member 129 2.45 0.36 0.46 NM_032005 Tbx19 T-box 19 2.23 0.35 0.42 Transcription elongation factor B (SIII), NM_026305 Tceb2 polypeptide 2 3.51 0.33 0.33 NM_013688 Tcte1 T-complex-associated testis expressed 1 3.79 0.29 0.44 Trimethylguanosine synthase homolog NM_054089 Tgs1 (S. cerevisiae) 3.16 0.35 0.50 Translocase of inner mitochondrial NM_013897 Timm8b membrane 8 homolog b (yeast) 3.85 0.33 0.46 Topoisomerase (DNA) II beta binding NM_176979 Topbp1 protein 3.22 0.37 0.49 NM_175114 Trak1 Trafficking protein, kinesin binding 1 2.58 0.24 0.34 NM_001024206 Trappc1 Trafficking protein particle complex 1 2.78 0.33 0.39 NM_197987 Trim37 Tripartite motif protein 37 3.81 0.29 0.31 NM_001013616 Trim6 Tripartite motif protein 6 2.66 0.31 0.40 NM_019562 Uchl5 Ubiquitin carboxyl-terminal esterase L5 2.66 0.19 0.26 Uncoupling protein 2 (mitochondrial, NM_011671 Ucp2 proton carrier) 3.30 0.28 0.36 NM_134196 V1re7 Vomeronasal 1 receptor, E7 2.19 0.31 0.48 NM_145842 V1re9 Vomeronasal 1 receptor, E9 3.24 0.28 0.32 NM_134217 V1rh8 Vomeronasal 1 receptor, H8 3.61 0.20 0.25 NM_011701 Vim Vimentin 2.96 0.28 0.36 NM_011702 Vip Vasoactive intestinal polypeptide 2.39 0.36 0.42 NM_016875 Ybx2 Y box protein 2 2.17 0.21 0.24 NM_028325 Zcchc12 Zinc finger, CCHC domain containing 12 3.23 0.30 0.37 NM_017467 Zfp316 Zinc finger protein 316 5.49 0.37 0.45 NM_001013745 Zfp57 Zinc finger protein 57 3.10 0.22 0.32 NM_153194 Zfp740 Zinc finger protein 740 2.12 0.32 0.50 Zinc finger with KRAB and SCAN NM_026107 Zkscan6 domains 6 2.56 0.27 0.32 NM_026649 4.59 0.22 0.27 NM_178391 2.42 0.29 0.29 NM_172419 3.05 0.32 0.30 NM_019427 2.85 0.30 0.34

243 NM_153168 2.31 0.37 0.37 NM_146422 3.32 0.34 0.38 NM_001033152 2.22 0.34 0.41 NM_177895 3.18 0.35 0.44 NM_001033809 2.69 0.33 0.47 NM_207226 2.58 0.35 0.47 NM_133695 2.77 0.30 0.49

244