Preface

MODERN APHERESIS TECH- blood, and the use of apheresis for therapeu- nology began in the 1950s with tic plasma exchange and cell depletion. The development of the Cohn centri- fourth edition of Apheresis: Principle and fuge bowl employed for plasma Practice has separated these into three dis- collection and subsequent return tinct volumes designed to provide a compre- of red blood cells. Use in transfusable compo- hensive examination of the scientific, nent donation was initially driven by the technical, and practical aspects of the uses of desire for granulocytes in the treatment of apheresis instruments in therapeutic apher- leukemia in the early 1960s. By the end of esis (Volume 1), donor apheresis (Volume 2), that decade, the role of dedicated single- and cellular therapy (Volume 3). donor platelets for transfusion of patients The editors believe this updated series refractory to whole blood-derived pools was will be of interest to readers with a specific recognized. Cumbersome serial manual sepa- focus, as well as serving as a comprehensive ration of platelets (and plasma for fraction- source of information regarding the use of ation) was replaced by continuous flow apheresis in blood banking and as a thera- centrifugation devices developed in the 1970s peutic modality. by companies based upon either the National Volume 2 specifically focuses on collection Cancer Institute/International Business of blood components by apheresis. The first Machines separator designed for granulocya- chapter provides an overview of donor sep- tapheresis (NCI-IBM 2990) or the Cohn ADL arator principles and function, along with Blood Fractionator. The substantial effort the evolution of instruments in use. Subse- involved in program maintenance and quent chapters describe donor physiology advantages of apheresis platelet and double and the short- and long-term effects of apher- red blood cell products have contributed to esis (Chapter 2); selection, education, and the widespread use of apheresis technology care of apheresis blood donors (Chapter 3); by blood collectors. Devices capable of multi- automated red cell donation (Chapter 4); and component separation and component manu- automated plasma donation (Chapter 5). facture at the donation site are standard Several chapters focus on plateletapheresis worldwide and remain a substantial source as a dominant driver of blood collector use of of many countries’ blood supplies. these instruments. Chapters describe plate- Previous editions of this text have com- let storage considerations (Chapter 6); the bined, within a single book, reviews of apher- role of apheresis platelets in patient care esis technologies along with their (Chapter 7); the importance of platelet bacte- applications in blood component collection, rial contamination of apheresis platelets cellular therapy, extracorporeal treatment of (Chapter 8); platelet pathogen inactivation

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(Chapter 9); and donor-patient platelet therapeutics, and new clinical studies matching (Chapter 10). The final two chap- requires periodic updating for texts to ters address granulocyte transfusion (Chap- remain current with modern apheresis blood ter 11) and quality management of apheresis donation and product use. We believe that programs (Chapter 12). this will be a valuable resource for years to The authors of these chapters are techni- come. cal experts and accomplished professionals As editors, we would like to acknowledge in blood banking and transfusion medicine. the superb support of AABB staff and techni- This volume is intended for learners at every cal editors in bringing this fourth edition to level in the health-care professions, blood col- press. We owe a significant debt of gratitude lection industry, and instrument manufac- to previous chapter authors who have pro- ture; that is, those who are involved in vided a superb foundation for this new edi- apheresis instrument development, blood tion, while its many new and returning donor and apheresis program management, authors have worked on often tight timelines blood component collection, the practice of to review the latest literature and provide blood banking/transfusion medicine, and updated content and valuable current individuals who administer blood products. sources for further reading. Some final These include physicians, scientists, technol- thanks are due to you the reader, for provid- ogists, trainees, students, administrators, ing a critical service to patients and main- and program support staff. taining proficiency in a rapidly-evolving Each chapter has been fully updated since field. the release of the third edition over 10 years ago. The field of blood banking and transfu- Ralph R. Vassallo, MD, FACP sion medicine is ever-changing and the emer- Jeffrey L. Winters, MD gence of new technologies, novel Editors

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