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Changes to the Technical Manual, 18Th Edition Program #144835 Monday, November 17, 2014 12:00 Pm-1:30 Pm (ET) ~ 5:00 Pm-6:30 Pm (GMT)

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Changes to the Technical Manual, 18Th Edition Program #144835 Monday, November 17, 2014 12:00 Pm-1:30 Pm (ET) ~ 5:00 Pm-6:30 Pm (GMT) Changes to the Technical Manual, 18th Edition Program #144835 Monday, November 17, 2014 12:00 pm-1:30 pm (ET) ~ 5:00 pm-6:30 pm (GMT) This audioconference will summarize the new and different content in the 18th edition of the AABB Technical Manual. Ample time will be provided for audience questions. Objectives: Identify changes in the new edition. Describe the rationale behind the major updates. Faculty: Connie Westhoff, PhD, (ASCP) SBB Director New York Blood Center Mark Fung, MD, PhD Medical Director, Blood Bank and Transfusion Services Fletcher Allen Health Care/ University of Vermont In accordance with AABB Policy on Disclosure of Faculty Relations, the faculty for this event have signed a conflict of interest form in which they have disclosed any significant financial interests or other relationships with industry relative to the topics that they will discuss at this program. Such disclosures allow you to better evaluate the objectivity of the information presented in the lectures. Faculty: Connie Westhoff, PhD, (ASCP) SBB Director New York Blood Center Disclosures: No disclosures given Mark Fung, MD, PhD Medical Director, Blood Bank and Transfusion Services Fletcher Allen Health Care/ University of Vermont Disclosures: No disclosures given Name/Role in Content Planning Disclosure Nature of relationship Manufacturer/Provider Colleen Aronson, planning none committee member Robert Braun, planning committee none member Nancy Dunbar, planning committee none member Jennifer Ford, planning committee none member GASCO Eastern District Federal Credit Union - Michele Hayes, planning committee yes Professional Chair of Supervisory member Committee Nora Hirschler, board representative yes Professional ABC Member Gail Moskowitz, planning committee Board of Directors, Guide to yes Professional member Cord Blood Foundation Jayanna Slayten, planning committee none member Linda Stefaniak, planning committee none member Kristina Williams, planning none committee member Sharon Moffett, staff member none Lauren Rohde, staff member none Alyson Wagner, staff member none Accessing your Continuing Education Credits Online! 1. Log into the Live Learning Center from the www.aabb.org website 2. Go to “Professional Development” 3. Click on red link that says “AABB Live Learning Center” on the left side of the page 4. Click on red link that says “AABB Live Learning Center” in the center of the page 5. Click the “My Account” link at the top of the page. 6. Log in using your e-mail address and password. 7. Click on the link that says “My Transcripts” 8. Go to the “Select Conference” drop down menu and select 2014 Audioconference Series 9. Choose the appropriate audioconference title. The AABB Technical Manual 18th Edition What’s new? www.aabb.org Technical Manual by the Numbers • 1953 =year of first edition • 69 = number of authors/editors this edition • 370,378 = word count • 96 = number of methods • 60 = number of countries where TM is used www.aabb.org It’s a Process www.aabb.org Overview of Changes Major • Molecular testing • Patient blood management • Cellular therapy • Methods Minor • Throughout www.aabb.org 1: Quality Systems 2: Facilities and Safety • These 2 chapters are comprehensive discussions of AABB core competencies • Updates made to keep the content current - Additional detail in table on internal event reporting and in appendix on quality-related CFR references - Information on work injuries formerly in table is now worked into the text • TL Motschman, BW Jett, SL Wilkinson • BW Jett, SL Wilkinson, TL Motschman www.aabb.org 3: Regulatory Issues • Significant revisions in the 17th edition underwent limited improvements this time • References updated • Transfusion therapy and safety citations formerly in table now worked into text and reference list • G Ramsey www.aabb.org 4: Disaster Management • Streamlining of content for easier reading • Lessons learned from recent disasters (May 2001 to present) now an online resource, continuously updated • RD Sylvester, W FitzGerald, W Trivisonno, T Wiegmann www.aabb.org 5: Blood Donor Selection • Substantially rewritten to reflect the changes that have taken place in the last 3-4 years - New donor deferrals - Updated DHQ - FDA approval of abbreviated DHQ • Less emphasis on how we got to where we are and more emphasis on what is key knowledge for today • AF Eder, M Muniz www.aabb.org 6: Whole Blood Collection • Reflects changes of the last 3-4 years - Move away from rejuvenation - Diversion pouch - New plasma products • Additive solutions used outside the US • LJ Dumont, M Papari, CA Aronson, DF Dumont www.aabb.org 7: Collection by Apheresis • FDA black box warning for HES • Information on Optia device for collection of granulocytes • Reflects the 2013 ASFA indication categories • JW Smith www.aabb.org 8: Infectious Disease Screening • Significant revisions in the 17th edition underwent limited improvements this time • Tables and text updated with EID information through March 2014 • SA Galel www.aabb.org 9: Storage, Processing, Distribution • Rewritten, new emphasis—Hospital Storage, Monitoring, Pretransfusion Processing, Distribution, and Inventory Management of Blood Components • Table of requirements for components now includes transportation conditions as well as those for storage • Inventory management aspects of massive and urgent transfusion—clinical aspects in Ch 15 • NM Dunbar www.aabb.org 10: Molecular Biology • A great chapter for reviewing the principles behind the test methods • Updated, particularly the section on antibody structure/function and its relationship to transfusion complications • JC Zimring, SL Spitalnik www.aabb.org 11: Blood Group Genetics • New content on DNA-based assays –Predicting blood groups –Use in prenatal practice –Testing antigen-negative blood donors –Confirming D type of donors –Discrepancies between phenotypes (serology) and genotypes (DNA testing) • C Lomas-Francis www.aabb.org 12: ABO, H, and Lewis • Author provided new insights without losing the core material • Excellent content from the 17th edition was retained, but updated • L Cooling www.aabb.org 13: Rh System • Updated Rh antigen table includes new antigens –RH59 (CEAG) –RH60 (PARG) –RH61 (CEVF) • Refreshed, yet retains the core material • GA Denomme, CM Westhoff www.aabb.org 14: Other Blood Groups • New ISBT blood group systems –FORS –JR –Lan –Vel • CD59 and mutations in erythroid-specific transcription factors • JR Storry www.aabb.org 15: Pretransfusion Testing • Text and references updated to reflect additions to the literature • Consolidated content on clinical aspects of massive and urgent transfusion • KA Downes, IA Shulman www.aabb.org 16: Antibodies to Red Cell Antigens • New antigens included • Key tables reformatted for easier use • PS Walker, JR Hamilton www.aabb.org 17: DAT and Immune-Mediated Hemolysis • Significant revisions in the 17th edition needed only minor adjustments this time • General updating and streamlining • RM Leger www.aabb.org 18: Platelet and Granulocyte Antigens and Antibodies • New antigens included • New illustrations –Platelet antigen tables –Diagram of MACE and MAIPA –Neutrophil antigen table • BR Curtis www.aabb.org 19: HLA System • General updating and streamlining • Updated URLs for HLA database refs • RA Bray, MS Pollack, HM Gebel www.aabb.org 20: Hemotherapy Decisions • Revisions to chapter emphasize restrictive transfusion strategies • Updates throughout; many new studies cited • T Nester, S Jain, J Poisson www.aabb.org 21: Blood Administration • New discussion on the use of premedication • A little reorganization to better match the sequence of activities • K Maynard www.aabb.org 22: Perinatal Issues • Some reorganization to improve readability • Newer technology—Doppler ultrasound –Liley or Queenan graphs removed –Amniocentesis still used in some settings • MS Kennedy, M Delany, S Scrape www.aabb.org 23: Neonatal/Pediatric • Continues the discussion found in the 17th edition on RBC transfusion indications –RBC age; ARIPI trial data –Restrictive vs liberal transfusion strategies; TOP trial • Newer literature reports included in refs • CD Josephson, E Meyer www.aabb.org 24: Patient Blood Management • Completely rewritten • Explains how the scope of PBM encompasses more than operating room activities • Updates on newly available pharmacologic agents • Covers PBM program implementation • M Ghiglione, KE Puca www.aabb.org 25: Transfusion Support of HSCT • Most recent data are included, especially findings from recent studies on platelet support • New discussions –Information portability –Pediatric HSCT –Autologous HSCT • CA Tormey, JE Hendrickson www.aabb.org 26: Therapeutic Apheresis • Updated to reflect 2013 ASFA indication categories • New table on modalities • RD Davenport www.aabb.org 27: Noninfectious Complications • Revisions made to bring chapter up to date, but without losing the stellar content from the 17th edition • TRALI risk mitigation update • CA Mazzei, MA Popovsky, PM Kopko www.aabb.org 28: Blood Utilization Review • Revisions reflect the increased level of interest in this activity as part of PBM program implementation • Newest study data included • A Tinmouth, S Stanworth www.aabb.org 29: HPC Collection • Completely revised • Compares and contrasts the sources of HPCs - Collection - Processing • Primary focus on marrow- and apheresis- derived HPCs • SA Koepsell, EK Jacob, DH McKenna www.aabb.org 30: Cord Blood Banking • Emphasis in chapter reflects changes “on the front lines” - Growth in UCB banking - Regulatory activity • AM
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