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postgraduate degrees. The university is named after the 14th* centuryPZI scholar and last Welsh Prince of Wales; Owain Glyndŵr Hypurin Porcine 10ml Vial 3ml Cartridge your and��� was ����� formed ����� with the��������� North East ��� Wales ������ Institute ����� (NEWI)�������� and the���� North ��r Wales���� School���ur��� of Art ������ and Design. ���u Th���e institution ���Neutral ����� ����� ��������� ��� ������ ����� �������� ���� ��r ���� ���ur��� ������ ���u��� was founded in 1887 as the Wrexham School of Science and Art. I��ul���� a�a�la�le �� t�e ��ll����� �re�e�ta����� Isophane to your Coleg30/70 Cambria mix (previously known as Yale College / Coleg Iâl) is������� the main u������ provider r���r���� of adult � educationr������� �������� in Wrexham and is one of the largest colleges in Wales. 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SIDE EFFECTS: Lipodystrophy�� ���u or roedema��� at� injectionO���� carers about their adverse experiences with synthetic IfINSULINS: sportsB����e PRESENTATIONS: is moreI��ul��Vials andyour t�cartridges �e thing containing .Alter�a��e ..Crystalline Wrexham Insulin Ph Eur P�r���e(Bovine)is hom 100 esite; to hypersensitivity; the o ldest ��allergic ��������u���� reactionsinternational to preservatives, zinc football and�� protamine. ���u stadium Rarely,r��� severe �O acute���� in the world and Isophaneat the heart is the GM insulin showed the following: units per ml or Crystalline Insulin Ph Eur (Porcine) 100 units per ml. USE: Treatment of insulin dependent oedema, most often���u��� on initiation of���� therapy.Hypurin PHARMACEUTICAL��� ����� PRECAUTIONS: ��� �u���� StoreBovine between �� 2°C ���u r��� Wrdiabetesexham ��t��ra�� mellitus. 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Bovine Neutral: a 10 professionalml vials: £27.72, rugby leagueon prescriptionPZI club and founded made by Owen Mumford.���ur�� www.owenmumford.com ���u��� ��� ��r�r����� �� �� ��� Aut��e�� Cla���� ���- Porcine���ur��� Neutral may be mixed B����e with Hypurin Porcine Isophane.���ur���Hypurin Bovine & P�r���eHypurin Porcine 3 ml cartridges (5 pack):O����� £41.58 Hypurin ���u���� Bovine Isophane: ������ 10 ml vials:r £27.72,�� ���u���� 3 ml cartridges ur� � 41% - loss of warnings of hypos or ‘I function 9% - blood glucose levels dipping and IDDT’s survey of people with diabetes and their family inIsophane: 2011,By subcutaneous which injection; is basedonset of action at within Queensway 2 hours, duration 18-24 Stadium hours. May also in(5 pack):Wrexham £41.58 Hypurin��r ���� Bovine(as Lente of��u� or2017) Protaminer�� ���Zinc:#AchieveTogether. 10 ��������ml vials: £27.72 LEGAL ����� CATEGORY: ���� on automatic pilot’ peaking erratically Just To Remind You .... carers about their adverse experiences with synthetic be givenNeutral intramuscularly. Hypurin Porcine 30/70 Mix: By subcutaneousNeutral injection; onset of action POM PL NUMBERS: Hypurin�r���� Bovine Neutral:��u� vialsr ��29831/0125, ��� cartridges�������� 29831/0127 ����� Hypurin Bovine ���� ABBREVIATED PRESCRIBING INFORMATION FOR������� HYPURIN BOVINEr AND������� HYPURIN PORCINE ��������� Dose may need adjustment �� during �r���r����� lactation. SIDE EFFECTS: Lipodystrophy ��� or ����oedema at injection �� O��� within 2 hours, duration up to 24 hours. May also be given intramuscularly. Hypurin Bovine Lente: Isophane: vials 29831/0120, cartridges 29831/0123Isophane Hypurin Bovine Lente: vials 29831/0129 Hypurin INSULINS: PRESENTATIONS: Vials and cartridges������� 34%containing - extreme Crystalliner tiredness Insulin������� Ph Euror lethargy(Bovine) 100��������� site; hypersensitivity;8% �� allergic - described �r���r�����reactions by to theirpreservatives, families zinc as ‘notand ��� protamine.the ���� Rarely, severe acute �� O��� GM insulin showed the following: TheBy subcutaneous countr injectionyside only; onset wins of action the about go2 hours,ld durationstar: up prettyto 30 hours. valleys,Hypurin Bovine forests Protamine ������r,Zinc: the vials Clwydi29831/0128 �r���� Hypurinan �� hillsPorcine ������ Neutral:are just vials�� 29831/0126, ���� 20mins �� cartridges ������ off the North Walesunits*Hypurin per ml insulin orCoast Crystalline 3ml cartridges withInsulin Ph fit Eur in (Porcine)the Autopen 1009% ®unitsClassic per - sleeping ml.pen-injectorUSE: Treatment all device,the timeof insulinavailable dependent oedema, most often on initiationsame person’of therapy. PHARMACEUTICAL PRECAUTIONS: Store between 2°C Bovine Protamine Zinc: By subcutaneous injection only; onset of action after 4-6 hours, duration 24- 29831/0124 Hypurin ����rPorcine Isophane: �r���� vials 29831/0121, �� ������ cartridges 29831/0122�� ���� Hypurin �� Porcine������ diabeteson prescription mellitus. andDOSAGE made AND by OwenADMINISTRATION: Mumford. www.owenmumford.com32%To be determined - weight by increase the physician of 1.5according stones to the and 8°C; do not5% freeze. - Cartridges mood changes, in use must described not be stored as in diffi a refrigerator.cult Cartridges and vials in Dee36 hours.�u�ur��� ValleyCONTRAINDICATIONS: on B����e Wrexham'sHypoglycaemia. PRECAUTIONS doorstep.�u�ur��� & WARNINGS: A HypurinP�r���e list Isophane, of local30/70 c Mix:ount vials 29831/0118, ry parks cartridges and 29831/0119 tourist PRODUCT attractions LICENCE HOLDER: Wockhardtcan be UK found here.needs of the patient. Hypurin Bovine & Hypurin Porcine�u��� Neutral:(21 pounds)By subcutaneousr�� and above injection;������e��u���r����� onset of use may be kept at room totemperature live with (maximum 25°C) for four weeks. Restrict use of each vial to a On average the adverseIDDT’s survey effects of did people not appearwith diabetes until 13 and months their family after treatment with ‘human’ insulin 30/70 Mix, Lente and Protamine Zinc preparations should not be given intravenously. Hypurin Bovine Ltd, Wrexham, LL13��u� 9UF Dater of�� last ���revision: MayLente��������� 2010. action within 30-60 minutes, duration 6-8 hours. May also be given intramuscularly or intravenously. single patient. PACKAGE QUANTITIES AND COST: Hypurin Porcine Neutral, Isophane or 30/70 Mix: Just To Remind You .... ABBREVIATED PRESCRIBING INFORMATION FOR HYPURIN�u���28% BOVINE - feeling AND unwell rHYPURIN�� all PORCINEthe������e��u���r����� time Dose may need adjustment 7%during lactation. - pains,SIDE especially EFFECTS: Lipodystrophyin the legs or and oedema joints at injection began and most carerspeople about complained their adverse of 3 orexperiences 4 of the following with synthetic adverse reactions: Neutral and Hypurin Bovine Protamine Zinc should not be mixed together. Monitor blood or urine glucose �u�r�� ��� ��������� Hypurin Bovine Neutral may be mixed with Hypurin Bovine Isophane and Hypurin Bovine Lente. Hypurin 10 ml vials: £25.20, 3 ml cartridges (5 pack): £37.80 Hypurin Bovine Neutral: 10 ml vials: £27.72, patients! and urinaryI����a�e ketones. Dosage adjustments may be required duringI����a�e illness, infection, trauma, surgery, INSULINS: PRESENTATIONS: Vials and cartridges containing24% Crystalline - memory Insulin lossPh Eur or (Bovine) confusion 100 site; hypersensitivity; allergic reactions to preservatives, zinc and protamine. Rarely, severe acute GM insulin showed the following: Take a look at the many other things to do in WrexhaAdversem reactions via theshould befollo reported.wing Reporting links; forms and informationTop 10 can bethings found to do in Wrexham,Porcineunits per Neutralml or Crystalline may be Insulin mixed Ph withEur (Porcine) Hypurin 100 Porcine units per Isophane. ml. USE: TreatmentHypurin Bovineof insulin &dependent Hypurin Porcineoedema, most3 mloften cartridges on initiation4% (5 ofpack): therapy. - irregular £41.58PHARMACEUTICAL Hypurin or late Bovine periods PRECAUTIONS: Isophane: 10Store ml between vials: £27.72,2°C 3 ml cartridges 41% - loss of warnings of hypos or ‘I function 9% - blood glucose levels dipping and puberty, emotional upset or periods of increased activity, with liver, kidney, adrenal, pituitary or thyroid at www.yellowcard.gov.uk. Adverse reactions should also be reported to the Drug Safety disease, coeliac disease and on transfer from other insulin preparations. In severe renal impairment PZI Isophane:diabetes mellitus.By subcutaneousDOSAGE AND injection;ADMINISTRATION: onset of Toaction be determined within 2 byhours, the physician duration according 18-24 hours.to the Mayand also 8°C; do(5 not pack): freeze. £41.58 Cartridges Hypurin in use Bovinemust not Lente be stored or Protamine in a refrigerator. Zinc: Cartridges 10 ml vials: and £27.72vials in LEGAL CATEGORY: on automatic pilot’ peaking erratically Activities and days out with the kids, Glyndŵ r / WAH Eventsand Information, and Department be at Wockhardtsure to UK (Tel: check 01978 661261). out Wrexham's good pbeneedsub given ofg theuid intramuscularly. patient.e Hypurinfor HypurinBovine & PorcineHypurin Porcine30/70 Neutral:Mix: ByBy subcutaneous subcutaneous injection;injection; onset onset of of useaction may be POMkept atPL room NUMBERS: temperatureHypurin (maximum Bovine 25°C) Neutral: for four vials weeks. 29831/0125, Restrict use cartridges of each vial29831/0127 to a Hypurin Bovine On average the adverse effects did not appear until 13 months after treatment with ‘human’ insulin dose reduction may be necessary and the compensatory response to hypoglycaemia may be impaired. Sadly so many years later, IDDT are still receiving reports from people using human and analogue insulin. 34% - extreme tiredness or lethargy 8% - described by their families as ‘not the Improved blood glucose control may be associated with loss of warning symptoms of hypoglycaemia. withinaction within2 hours, 30-60 duration minutes, up duration to 24 hours.6-8 hours. May May also also be be given given intramuscularly. intramuscularly orHypurin intravenously. Bovine Lente:single patient.Isophane:PACKAGE vials QUANTITIES 29831/0120, AND cartridgesCOST: Hypurin 29831/0123 Porcine Neutral, Hypurin Isophane Bovine or Lente: 30/70 vialsMix: 29831/0129 Hypurin began and most people complained of 3 or 4 of the following adverse reactions: ourInadequately Award stabilised winningpatients may not bePubs fit to drive in or andoperate machinery.aroundPREGNANCY the WrexhamAND Wockhardt UK, Town. Ash Road North, Wrexham, LL13 9UF ByHypurin subcutaneous Bovine Neutral injection may be only;mixed onsetwith Hypurin of action BovineInsulin about Isophane Dependent2 hours, and Hypurin duration Diabetes Bovine up Lente.Trustto 30 Hypurin(IDDT) hours. NewsletterHypurin10 ml vials: MarchBovine £25.20, 2012 Protamine 3 ml cartridges Zinc: (5 vialspack): 29831/0128 £37.80 Hypurin Hypurin Bovine PorcineNeutral: 10Neutral: ml vials: vials £27.72, 29831/0126, cartridges 9% - sleeping all the time same person’ LACTATION: Insulin requirements may be decreased in early stages, increased in second and third Tel: 01978 661261 Fax: 01978 660130 BovinePorcine NeutralProtamine may beZinc: mixedBy subcutaneouswith Hypurin Porcine injection Isophane. only; onsetHypurin of actionBovine after& Hypurin 4-6 hours, Porcine duration 3 ml24- cartridges29831/0124 (5 pack): £41.58Hypurin HypurinPorcine Bovine Isophane: Isophane: vials 1029831/0121, ml vials: £27.72, cartridges 3 ml cartridges29831/0122 Hypurin Porcine 41% - loss of warnings of hypos or ‘I function 9% - blood glucose levels dipping and Isophane: By subcutaneous injection; onset of action within 2 hours, duration 18-24 hours. May also (5 pack): £41.58 Hypurin Bovine Lente or Protamine Zinc: 10 ml vials: £27.72 LEGAL CATEGORY: 32% - weight increase of 1.5 stones 5% - mood changes, described as difficult HP04/12 February 2012 trimesters; insulin requirements should be assessed frequently by an experienced diabetes physician. www.wockhardt.co.uk [email protected] 36 hours. CONTRAINDICATIONS: Hypoglycaemia. PRECAUTIONS & WARNINGS: Hypurin Isophane, 30/70 Mix: vials 29831/0118, cartridges 29831/0119 PRODUCT LICENCE HOLDER: Wockhardt UK on automatic pilot’ peaking erratically Where to buy in Wrexham? be given intramuscularly. Hypurin Porcine 30/70 Mix: By subcutaneous injection; onset of action POM PL NUMBERS: Hypurin Bovine Neutral: vials 29831/0125, cartridges 29831/0127 Hypurin Bovine (21 pounds) and above to live with 30/70 Mix, Lente and Protamine Zinc preparations should not be given intravenously. Hypurin Bovine Ltd, Wrexham, LL13 9UF Date of last revision: May 2010. 34% - extreme tiredness or lethargy 8% - described by their families as ‘not the within 2 hours, duration up to 24 hours. May also be given intramuscularly. Hypurin Bovine Lente: Isophane: vials 29831/0120, cartridges 29831/0123 Hypurin Bovine Lente: vials 29831/0129 Hypurin 28% - feeling unwell all the time 7% - pains, especially in the legs and joints Wrexham properties for sale please click here and information on rental properties click here. NeutralBy subcutaneous and Hypurin injection Bovine only; Protamine onset of Zinc action should about not 2 behours, mixed duration together. up to Monitor 30 hours. bloodHypurin or urine glucoseBovine Protamine Zinc: vials 29831/0128 Hypurin Porcine Neutral: vials 29831/0126, cartridges 9% - sleeping all the time same person’ andBovine urinary® Protamine ketones. 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PRECAUTIONS & WARNINGS: Hypurin Isophane, 30/70 Mix: vials 29831/0118,at www.yellowcard.gov.uk. cartridges 29831/0119 Adverse PRODUCT reactions LICENCE should HOLDER: also be Wockhardtreported toUK the Drug Safety (21 pounds) and above to live with disease,30/70 Mix, coeliac Lente anddisease Protamine and onZinc transfer preparations from shouldother notinsulin be givenpreparations. intravenously. In severe Hypurin renalBovine impairment Ltd, Wrexham, LL13 9UF Date of last revision: May 2010. 4657 Hypurin A4 LP_AW2.indd 2-3 on prescription and made by Owen Mumford. www.owenmumford.com and Information Department at Wockhardt UK (Tel: 0197805/03/2012 661261). 12:52 28% - feeling unwell all the time 7% - pains, especially in the legs and joints doseNeutral reduction and Hypurin may Bovine be necessary Protamine andZinc shouldthe compensatory not be mixed together.response Monitor to hypoglycaemia blood or urine mayglucose be impaired. 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In severe renal impairment Just To Remind You .... LACTATION: Insulin requirements may be decreased in early stages, increased in second and third Tel: 01978and Information 661261 Department Fax: 01978 at 660130 Wockhardt UK (Tel: 01978 661261). carers about their adverse experiences with synthetic ABBREVIATED PRESCRIBING INFORMATION FOR HYPURINdose reduction may BOVINE be necessary andAND the compensatory HYPURIN response PORCINE to hypoglycaemia may Dosebe impaired. may need adjustment during lactation. SIDE EFFECTS: Lipodystrophy or oedema at injection

HP04/12 February 2012 Sadly so many years later, IDDT are still receiving reports from people using human and analogue insulin. trimesters;Improved blood insulin glucose requirements control may should be associated be assessed with loss frequently of warning by symptoms an experienced of hypoglycaemia. diabetes physician. www.wockhardt.co.uk [email protected] INSULINS: PRESENTATIONS: Vials and cartridges containingInadequately Crystallinestabilised patients Insulinmay not be Ph fit toEur drive (Bovine)or operate machinery. 100 PREGNANCYsite; ANDhypersensitivity; Wockhardt UK, Ash Roadallergic North, Wrexham, reactions LL13 9UF to preservatives, zinc and protamine. Rarely, severe acute Insulin Dependent Diabetes Trust (IDDT) Newsletter March 2012 GM insulin showed the following: units per ml or Crystalline Insulin Ph Eur (Porcine) 100 unitsLACTATION: per ml.InsulinUSE: requirementsTreatment may be decreased of insulin in early dependentstages, increased in secondoedema, and third mostTel: 01978 often 661261 onFax: 01978initiation 660130 of therapy. PHARMACEUTICAL PRECAUTIONS: Store between 2°C

HP04/12 February 2012 trimesters; insulin requirements should be assessed frequently by an experienced diabetes physician. www.wockhardt.co.uk [email protected] diabetes mellitus. DOSAGE AND ADMINISTRATION: To be determined by the physician according to the and 8°C; do not freeze. Cartridges in use must not be stored in a refrigerator. Cartridges and vials in

needs of the patient. Hypurin Bovine & Hypurin 4657Porcine Hypurin Neutral:A4 LP_AW2.inddBy subcutaneous 2-3 injection; onset of use may be kept at room temperature (maximum 25°C) for four weeks. Restrict use of each vial to a On average the adverse effects05/03/2012 did 12:52 not appear until 13 months after treatment with ‘human’ insulin action within 30-60 minutes, duration 6-8 hours. May also be given intramuscularly or intravenously. single patient. PACKAGE QUANTITIES AND COST: Hypurin Porcine Neutral, Isophane or 30/70 Mix: began and most people complained of 3 or 4 of the following adverse reactions: Hypurin Bovine Neutral may be mixed with Hypurin4657 Bovine Hypurin A4Isophane LP_AW2.indd and 2-3 Hypurin Bovine Lente. Hypurin 10 ml vials: £25.20, 3 ml cartridges (5 pack): £37.80 Hypurin Bovine Neutral: 10 ml vials: £27.72, 05/03/2012 12:52 Porcine Neutral may be mixed with Hypurin Porcine Isophane. Hypurin Bovine & Hypurin Porcine 3 ml cartridges (5 pack): £41.58 Hypurin Bovine Isophane: 10 ml vials: £27.72, 3 ml cartridges 41% - loss of warnings of hypos or ‘I function 9% - blood glucose levels dipping and Isophane: By subcutaneous injection; onset of action within 2 hours, duration 18-24 hours. May also (5 pack): £41.58 Hypurin Bovine Lente or Protamine Zinc: 10 ml vials: £27.72 LEGAL CATEGORY: on automatic pilot’ peaking erratically be given intramuscularly. Hypurin Porcine 30/70 Mix: By subcutaneous injection; onset of action POM PL NUMBERS: Hypurin Bovine Neutral: vials 29831/0125, cartridges 29831/0127 Hypurin Bovine within 2 hours, duration up to 24 hours. May also be given intramuscularly. Hypurin Bovine Lente: Isophane: vials 29831/0120, cartridges 29831/0123 Hypurin Bovine Lente: vials 29831/0129 Hypurin 34% - extreme tiredness or lethargy 8% - described by their families as ‘not the By subcutaneous injection only; onset of action about 2 hours, duration up to 30 hours. Hypurin Bovine Protamine Zinc: vials 29831/0128 Hypurin Porcine Neutral: vials 29831/0126, cartridges 9% - sleeping all the time same person’ Bovine Protamine Zinc: By subcutaneous injection only; onset of action after 4-6 hours, duration 24- 29831/0124 Hypurin Porcine Isophane: vials 29831/0121, cartridges 29831/0122 Hypurin Porcine 32% - weight increase of 1.5 stones 5% - mood changes, described as difficult 36 hours. CONTRAINDICATIONS: Hypoglycaemia. PRECAUTIONS & WARNINGS: Hypurin Isophane, 30/70 Mix: vials 29831/0118, cartridges 29831/0119 PRODUCT LICENCE HOLDER: Wockhardt UK (21 pounds) and above to live with 30/70 Mix, Lente and Protamine Zinc preparations should not be given intravenously. Hypurin Bovine Ltd, Wrexham, LL13 9UF Date of last revision: May 2010. Neutral and Hypurin Bovine Protamine Zinc should not be mixed together. Monitor blood or urine glucose 28% - feeling unwell all the time 7% - pains, especially in the legs and joints and urinary ketones. Dosage adjustments may be required during illness, infection, trauma, surgery, Adverse reactions should be reported. Reporting forms and information can be found 24% - memory loss or confusion 4% - irregular or late periods puberty, emotional upset or periods of increased activity, with liver, kidney, adrenal, pituitary or thyroid at www.yellowcard.gov.uk. Adverse reactions should also be reported to the Drug Safety disease, coeliac disease and on transfer from other insulin preparations. In severe renal impairment and Information Department at Wockhardt UK (Tel: 01978 661261). dose reduction may be necessary and the compensatory response to hypoglycaemia may be impaired. Sadly so many years later, IDDT are still receiving reports from people using human and analogue insulin. Improved blood glucose control may be associated with loss of warning symptoms of hypoglycaemia. Inadequately stabilised patients may not be fit to drive or operate machinery. PREGNANCY AND Wockhardt UK, Ash Road North, Wrexham, LL13 9UF Insulin Dependent Diabetes Trust (IDDT) Newsletter March 2012 LACTATION: Insulin requirements may be decreased in early stages, increased in second and third Tel: 01978 661261 Fax: 01978 660130

HP04/12 February 2012 trimesters; insulin requirements should be assessed frequently by an experienced diabetes physician. www.wockhardt.co.uk [email protected]

4657 Hypurin A4 LP_AW2.indd 2-3 05/03/2012 12:52