AWARDS, HONORS, DISTINGUISHED LECTURESHIPS Prof. Dr. Dieter Seebach
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Vincent Du Vigneaud
Vincent du Vigneaud May 18, 1901 — December 11, 1978 Vincent du Vigneaud was born in Chicago in 1901. He majored in chemistry at the University of Illinois at Urbana and received the Master of Science degree in 1924. H. B. Lewis and W. C. Rose introduced him to biochemistry, which became his major field of interest. At Urbana he supported himself by working as a waiter and teaching cavalry tactics and equitation as a reserve second lieutenant. He received his Ph.D. degree in 1927 from the University of Rochester for work on the chemistry of insulin. Insulin is a protein containing sulfur, an atom that became his life-long center of interest, as vividly told in his book A Trail of Research (Cornell University Press, 1952). For his postdoctoral work du Vigneaud moved to Baltimore with his wife, Zella, whom he had married in 1924, to work with J. J. Abel at Johns Hopkins. There, in the first steps following the sulfur trail, he worked on cystine, a constituent of insulin which Abel had crystallized in 1925. Du Vigneaud helped to establish that insulin is indeed a protein, an unpopular veiwpoint at the time. After another year of postdoctoral fellowship in Europe, du Vigneaud returned to Urbana as an assistant professor in physiological chemistry (1930-32). He continued his work on cystine and developed an important method for the reduction of the disulfide bond by metallic sodium in liquid ammonia. These reagents remained valuable tools in his hand for his later synthetic work. In 1932, at age 31, he was appointed chairman of biochemistry at George Washington University School of Medicine, where he remained for six years. -
Herbert Charles Brown, a Biographical Memoir
NATIONAL ACADEMY OF SCIENCES H E R B E R T Ch ARLES BROWN 1 9 1 2 — 2 0 0 4 A Biographical Memoir by E I-I CH I N EGIS HI Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 2008 NATIONAL ACADEMY OF SCIENCES WASHINGTON, D.C. Photograph Credit Here. HERBERT CHARLES BROWN May 22, 1912–December 19, 2004 BY EI -ICH I NEGISHI ERBERT CHARLES BROWN, R. B. Wetherill Research Profes- Hsor Emeritus of Purdue University and one of the truly pioneering giants in the field of organic-organometallic chemistry, died of a heart attack on December 19, 2004, at age 92. As it so happened, this author visited him at his home to discuss with him an urgent chemistry-related matter only about 10 hours before his death. For his age he appeared well, showing no sign of his sudden death the next morn- ing. His wife, Sarah Baylen Brown, 89, followed him on May 29, 2005. They were survived by their only child, Charles A. Brown of Hitachi Ltd. and his family. H. C. Brown shared the Nobel Prize in Chemistry in 1979 with G. Wittig of Heidelberg, Germany. Their pioneering explorations of boron chemistry and phosphorus chemistry, respectively, were recognized. Aside from several biochemists, including V. du Vigneaud in 1955, H. C. Brown was only the second American organic chemist to win a Nobel Prize behind R. B. Woodward, in 1965. His several most significant contribu- tions in the area of boron chemistry include (1) codiscovery of sodium borohyride (1972[1], pp. -
Alumni Newsletter
ALUMNI NEWSLETTER SCHOOL OF CHEMICAL SCIENCES UNIVERSITY OF ILLINOIS at Urbana-Champaign NO. 11, WINTER 1976-77 The State of the Union (Comments by H. S. Gutowsky, director of the School of Chemical Sciences) Following the tradition of the last three issues of the Alumni Newsletter, I have put together a synopsis of some selected material that appears in much more detail in the 1975-76 Annual Report of the School of Chemical Sci ences and is not covered elsewhere in this issue. If you would like more details, let me know and I will be happy to forward you a copy of the com plete annual report. Instructional Program Two steps were taken dw·ing the past year to address the fact that 75 per cent or more of our chemistry graduates take positions in industry without learning much in their programs about the nature of industrial careers. Professor Peter Beak organized a special topics course, Chemistry 433, Re search in Industry, given in the fall semester. Early in the course, Dr. J. K. Stille from the University of Iowa presented a series of ten lectures on the fundamentals of industrial and polymer chemistry. This was followed by eleven weekly lectures from industrial speakers active in chemical roles. The program attracted a good deal of interest among our students and staff and its beneficial effects were visible to industrial recruiters interviewing here near its end. The second step was the inauguration of a cooperative program with Monsanto Company (St. Louis) for the summer employment of graduate students. Three entering graduate students participated in the summer of 1976, and it is hoped to extend the program to a larger number of students (and other companies) as well as to faculty next summer. -
Curriculum Vitae Professor Dr. Martin Jansen
Curriculum Vitae Professor Dr. Martin Jansen Name: Martin Jansen Born: 5 November 1944 Main areas of research: preparative solid-state chemistry, crystal chemistry, materials research, structure-property relationship of solids Since 1998, he has been a member of the scientific council of the Max Planck Society and a director at the Max Planck Institute for solid-state research in StuttgartHe has developed a concept for plan- ning solid state syntheses, combining computational and experimental tools, that is pointing the way to rational and efficient discovery of new materials. Academic and Professional Career since 1998 Director at the Max Planck Institute for Solid State Research, Stuttgart and Honorary Professor at the University of Stuttgart, Germany 1987 - 1998 Professor (C4) and Director of the Institute at the University of Bonn, Germany 1981 - 1987 Professor (C4), Chair B for Inorganic Chemistry of the University of Hannover, Germany 1978 Habilitation at the University of Gießen, Germany 1973 Promotion (Ph.D.) at the University of Gießen, Germany 1966 - 1970 Study of Chemistry at the University of Gießen, Germany Honours and Awarded Memberships (Selection) 2019 Otto-Hahn-Prize 2009 Centenary Prize, Royal Society of Chemistry, UK 2009 Georg Wittig - Victor Grignard Prize, Société Chimique de France 2008 Member of acatech (National Academy of Science and Engineering) Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 1 2007 Karl Ziegler Award, Germany 2004 Honorary Doctorate of the Ludwig Maximilians-University of -
Peptide Chemistry up to Its Present State
Appendix In this Appendix biographical sketches are compiled of many scientists who have made notable contributions to the development of peptide chemistry up to its present state. We have tried to consider names mainly connected with important events during the earlier periods of peptide history, but could not include all authors mentioned in the text of this book. This is particularly true for the more recent decades when the number of peptide chemists and biologists increased to such an extent that their enumeration would have gone beyond the scope of this Appendix. 250 Appendix Plate 8. Emil Abderhalden (1877-1950), Photo Plate 9. S. Akabori Leopoldina, Halle J Plate 10. Ernst Bayer Plate 11. Karel Blaha (1926-1988) Appendix 251 Plate 12. Max Brenner Plate 13. Hans Brockmann (1903-1988) Plate 14. Victor Bruckner (1900- 1980) Plate 15. Pehr V. Edman (1916- 1977) 252 Appendix Plate 16. Lyman C. Craig (1906-1974) Plate 17. Vittorio Erspamer Plate 18. Joseph S. Fruton, Biochemist and Historian Appendix 253 Plate 19. Rolf Geiger (1923-1988) Plate 20. Wolfgang Konig Plate 21. Dorothy Hodgkins Plate. 22. Franz Hofmeister (1850-1922), (Fischer, biograph. Lexikon) 254 Appendix Plate 23. The picture shows the late Professor 1.E. Jorpes (r.j and Professor V. Mutt during their favorite pastime in the archipelago on the Baltic near Stockholm Plate 24. Ephraim Katchalski (Katzir) Plate 25. Abraham Patchornik Appendix 255 Plate 26. P.G. Katsoyannis Plate 27. George W. Kenner (1922-1978) Plate 28. Edger Lederer (1908- 1988) Plate 29. Hennann Leuchs (1879-1945) 256 Appendix Plate 30. Choh Hao Li (1913-1987) Plate 31. -
The Early Years-Across the Bench from Bruce (1963-1966)
The Early Years—Across the Bench From Bruce (1963–1966) The Early Years—Across the Bench From Bruce (1963–1966) Garland R. Marshall1,2 1Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University, St. Louis, MO 63110 2Department of Biomedical Engineering, Center for Computational Biology, Washington University, St. Louis, MO 63110 Received 14 July 2007; revised 20 September 2007; accepted 5 October 2007 Published online 16 October 2007 in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/bip.20870 a Nobel Laureate, Chairman of the Department of Biology at ABSTRACT: Caltech and a member of the National Academy of Science, and was still willing to recommend me for graduate studies This personal reflection on the author’s experience as at Rockefeller. Bruce Merrifield’s first graduate student has been I was convinced at the time that I was chosen to study adapted from a talk given at the Merrifield Memorial neurophysiology, having failed miserably to isolate the acetyl- Symposium at the Rockefeller University on November choline receptor from denervated rabbit muscle as an under- graduate at Caltech. The outstanding neurophysiologists at 13, 2006. # 2007 Wiley Periodicals, Inc. Biopolymers Rockefeller including H. Keffer Hartline, Nobel Laureate, (Pept Sci) 90: 190–199, 2008. were more interested, however, in the wiring diagrams of the Keywords: solid phase synthesis; Merrifield; DNA synthe- eye of the horseshoe crab2 than in how a small molecule sis; combinatorial chemistry could trigger the action potential. Thus, my first laboratory experience at Rockefeller was with Prof. Henry Kunkel, a This article was originally published online as an accepted prominent immunologist.3 Prof. -
MAY 03 Nucleus Sp-LAST
DED UN 18 O 98 F yyyy N yyyy Y O T R E I T H C E O yyyyN A E S S S L T A E A C R C I yyyyN S M S E E H C C T N IO A May 2003 Vol. LXXXI, No. 9 yyyyC N • AMERI Monthly Meeting Education Night at B.U. Guy Crosby speaks on Chemistry of Nutrition Election 2003 Election of candidates for 2004 Book Review Quantum Leaps in the Wrong Direction, by C. M. Wynn and A. W. Wiggins Historical Note Edward Frankland’s Crusade for Clean Water in the 19th Century template group. If this were true, then this end, a simple molecular modeling Meeting virtually any ring system which ful- exercise was undertaken to compare filled this requirement would lead to a the differences between our best com- series of potent inhibitors pound and those reported by Merck. Report We selected the 1H-pyrrole ring The simple overlay of these molecules From the April 10, 2003 Esselen system as our starting template to test revealed the presence of a methyl Award Address this hypothesis, primarily because group in the Merck compound in a these could readily be prepared from region of space not occupied by our The Discovery And 1,4-diketones through the classical inhibitors. Development Of Lipitor‚ Paal-Knorr condensation and these 1,4- To determine the importance of (Atorvastatin Calcium) diketones, in turn, were potentially occupying this space, bromine and available possessing a wide variety of chlorines were introduced into the 3- Bruce D. -
National Academy of Sciences July 1, 1979 Officers
NATIONAL ACADEMY OF SCIENCES JULY 1, 1979 OFFICERS Term expires President-PHILIP HANDLER June 30, 1981 Vice-President-SAUNDERS MAC LANE June 30, 1981 Home Secretary-BRYCE CRAWFORD,JR. June 30, 1983 Foreign Secretary-THOMAS F. MALONE June 30, 1982 Treasurer-E. R. PIORE June 30, 1980 Executive Officer Comptroller Robert M. White David Williams COUNCIL Abelson, Philip H. (1981) Markert,C. L. (1980) Berg, Paul (1982) Nierenberg,William A. (1982) Berliner, Robert W. (1981) Piore, E. R. (1980) Bing, R. H. (1980) Ranney, H. M. (1980) Crawford,Bryce, Jr. (1983) Simon, Herbert A. (1981) Friedman, Herbert (1982) Solow, R. M. (1980) Handler, Philip (1981) Thomas, Lewis (1982) Mac Lane, Saunders (1981) Townes, Charles H. (1981) Malone, Thomas F. (1982) Downloaded by guest on September 30, 2021 SECTIONS The Academyis divided into the followingSections, to which membersare assigned at their own choice: (11) Mathematics (31) Engineering (12) Astronomy (32) Applied Biology (13) Physics (33) Applied Physical and (14) Chemistry Mathematical Sciences (15) Geology (41) Medical Genetics Hema- (16) Geophysics tology, and Oncology (21) Biochemistry (42) Medical Physiology, En- (22) Cellularand Develop- docrinology,and Me- mental Biology tabolism (23) Physiological and Phar- (43) Medical Microbiology macologicalSciences and Immunology (24) Neurobiology (51) Anthropology (25) Botany (52) Psychology (26) Genetics (53) Social and Political Sci- (27) Population Biology, Evo- ences lution, and Ecology (54) Economic Sciences In the alphabetical list of members,the numbersin parentheses, followingyear of election, indicate the respective Class and Section of the member. CLASSES The members of Sections are grouped in the following Classes: I. Physical and Mathematical Sciences (Sections 11, 12, 13, 14, 15, 16). -
Vincent Du Vigneaud: Following the Sulfur Trail to the Discovery of the Hormones of the Posterior Pituitary Gland at Cornell Medical College
HISTORICAL VIGNETTE J Neurosurg 124:1538–1542, 2016 Vincent du Vigneaud: following the sulfur trail to the discovery of the hormones of the posterior pituitary gland at Cornell Medical College Malte Ottenhausen, MD,1 Imithri Bodhinayake, MD,1 Matei A. Banu, MD,1 Philip E. Stieg, PhD, MD,1 and Theodore H. Schwartz, MD1–3 1Department of Neurosurgery, Sackler Brain and Spine Center; 2Department of Otolaryngology; and 3Department of Neuroscience, Brain and Mind Institute, Weill Medical College of Cornell University, NewYork-Presbyterian Hospital, New York, New York In 1955, Vincent du Vigneaud (1901–1978), the chairman of the Department of Biochemistry at Cornell University Medical College, was awarded the Nobel Prize for Chemistry for his research on insulin and for the first synthesis of the posterior pituitary hormones—oxytocin and vasopressin. His tremendous contribution to organic chemistry, which began as an interest in sulfur-containing compounds, paved the way for a better understanding of the pituitary gland and for the development of diagnostic and therapeutic tools for diseases of the pituitary. His seminal research continues to impact neurologists, endocrinologists, and neurosurgeons, and enables them to treat patients who had no alternatives prior to du Vigneaud’s breakthroughs in peptide structure and synthesis. The ability of neurosurgeons to aggressively operate on parasellar pathology was directly impacted and related to the ability to replace these hormones after surgery. The authors review the life and career of Vincent du Vigneaud, his groundbreaking discoveries, and his legacy of the understanding and treatment of the pituitary gland in health and disease. http://thejns.org/doi/abs/10.3171/2015.5.JNS141952 KEY WORDS history; pituitary; Nobel Prize; Vincent du Vigneaud; chemistry; oxytocin; vasopressin ROUNDBREAKING scientific discoveries have paved tion in Illinois. -
National Medal of Science Recipients
THEROLE OF THEHIGH SCHOOLBIOLOGY TEACHER 271 time scheduledfor science subjects. There is I have emphasizedour need for scientific need for a curriculumthat would allow the and technicalmanpower, and particularlyour child to perform. As aptly stated by the need for public understandingof and public Steering Committee of the BSCS: ". no supportfor science. I have reviewedsome of child can comprehendwhat science is simply the dangerous and wasteful by-productsof by learningfacts about nature. Real involve- biological illiteracy, citing some of these as ment in scientificinquiry is needed, an active evidencethat there is a criticalneed for pub- participationthat can enable the learner to lic understandingof science. The heavy re- distinguish between experiment and instru- sponsibility for reversing the illiteracy falls on mentation, between evidence and authority, the high school biology teacher, but help should come from the entire scientific com- between science and magic... ." Borrowing munity, from the mass media-and indeed Downloaded from http://online.ucpress.edu/abt/article-pdf/27/4/271/22592/4440914.pdf by guest on 29 September 2021 from the phraseologyof a documentmemo- from all thinking citizens. Abraham Lincoln rized by all high school students: Among expressed it perfectly: "Public support is those truths we hold self-evident is that in everything,without it nothing can succeed, order to study life we must study the living. with it nothing can fail." National Medal of Science Teacher Education in East Africa Recipients Thirty American teachers are being sought Recently President Johnson presented elev- for two-year participation to serve as staff en National Medals of Science at a White members for primary and secondary training House ceremony. -
Robert Burns Woodward
The Life and Achievements of Robert Burns Woodward Long Literature Seminar July 13, 2009 Erika A. Crane “The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.” “Art and Science in the Synthesis of Organic Compounds: Retrospect and Prospect,” in Pointers and Pathways in Research (Bombay:CIBA of India, 1963). Robert Burns Woodward • Graduated from MIT with his Ph.D. in chemistry at the age of 20 Woodward taught by example and captivated • A tenured professor at Harvard by the age of 29 the young... “Woodward largely taught principles and values. He showed us by • Published 196 papers before his death at age example and precept that if anything is worth 62 doing, it should be done intelligently, intensely • Received 24 honorary degrees and passionately.” • Received 26 medals & awards including the -Daniel Kemp National Medal of Science in 1964, the Nobel Prize in 1965, and he was one of the first recipients of the Arthur C. -
Conformational Transition in Immunoglobulin MOPC 460" by Correction. in Themembership List of the National Academy of Scien
Corrections Proc. Natl. Acad. Sci. USA 74 (1977) 1301 Correction. In the article "Kinetic evidence for hapten-induced Correction. In the membership list of the National Academy conformational transition in immunoglobulin MOPC 460" by of Sciences that appeared in the October 1976 issue of Proc. D. Lancet and I. Pecht, which appeared in the October 1976 Natl. Acad. Sci. USA 73,3750-3781, please note the following issue of Proc. Nati. Acad. Sci. USA 73,3549-3553, the authors corrections: H. E. Carter, Britton Chance, Seymour S. Cohen, have requested the following changes. On p. 3550, right-hand E. A. Doisy, Gerald M. Edelman, and John T. Edsall are affil- column, second line from bottom, and p. 3551, left-hand col- iated with the Section ofBiochemistry (21), not the Section of umn, fourth line from the top, "Fig. 2" should be "Fig. 1A." Botany (25). In the legend of Table 2, third line, note (f) should read "AG, = -RTlnKj." On p. 3553, left-hand column, third paragraph, fifth line, "ko" should be replaced by "Ko." Correction. In the Author Index to Volume 73, January-De- cember 1976, which appeared in the December 1976 issue of Proc. Natl. Acad. Sci. USA 73, 4781-4788, the limitations of Correction. In the article "Amino-terminal sequences of two computer alphabetization resulted in the listing of one person polypeptides from human serum with nonsuppressible insu- as the author of another's paper. On p. 4786, it should indicate lin-like and cell-growth-promoting activities: Evidence for that James Christopher Phillips had an article beginning on p.