US 20110020414A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0020414 A1 KUNIN (43) Pub. Date: Jan. 27, 2011
(54) MOISTURIZING RETINOL COMPOSITION A61K 8/44 (2006.01) A6IR 8/37 (2006.01) (76) Inventor: Audrey KUNIN, Mission Hills, KS A6IR 8/365 (2006.01) (US) A6IR 8/38 (2006.01) A6IR 8/60 (2006.01) Correspondence Address: A6IR 8/27 (2006.01) HUSCH BLACKWELL LLP 4801 Main Street, Suite 1000 (52) U.S. Cl...... 424/401: 514/725; 424/738; 424/730; KANSAS CITY, MO 64112 (US) 514/669; 424/725; 424/773; 424/778; 514/357; 514/567; 514/510; 514/557; 424/765: 514/714; (21) Appl. No.: 12/844,368 514/422:514/29: 514/154; 424/642; 424/750 (22) Filed: Jul. 27, 2010 (57) ABSTRACT Related U.S. Application Data An anti-aging composition is provided that contains high potency retinol along with anti-irritant properties. In particu (60) Provisional application No. 61/228,788, filed on Jul. lar, an anti-aging composition includes a base, from about 27, 2009. 0.001% to 20.0 vol% retinol, at least one anti-irritant agent, at least one antioxidant, at least one anti-inflammatory agent, Publication Classification and a moisturizing complex. In one non-limiting illustration, (51) Int. Cl. the anti-aging composition contains about 1.0 Vol.% retinol, A6 IK 8/67 (2006.01) plantago lanceolata, hypericum perforatum leaf extract, A61O 19/08 (2006.01) phytosphingosine, leontopodium alpinum extract, glycyrriza A6 IK 8/II (2006.01) glabra root extract, Sambucus nigra flower extract, nordihy A 6LX 8/97 (2006.01) drognaiaretic acid, oleanolic acid, spiraea ulmaria flower A6 IK 8/4I (2006.01) extract, evodia rutaecarpa fruit extract, boswellia serrata A6 IK 8/49 (2006.01) extract, and additives. US 2011/0020414 A1 Jan. 27, 2011
MOISTURIZING RETNOL COMPOSITION creams, lotions or gels containing retinol (Vitamin A) or related compounds. Topical retinoids are often effective treat CROSS-REFERENCE TO RELATED ment for mild to severe acne. People that are prone to acne APPLICATIONS have to be careful what type of lotions and creams they use so as to not make their acne worse. In addition to the above 0001. This application is a nonprovisional of and claims mentioned side effects, a user may also develop irritation to priority to the U.S. Provisional Patent Application Ser. No. the skin or adjacent mucous membranes and the production of 61/228,788, filed Jul. 27, 2009, which document is hereby excessive oiliness or greasiness of the skin which can clog incorporated by reference in its entirety to the extent permit pores. Therefore, it would be beneficial to have a skin care ted by law. treatment that contains potent retinol that will not clog pores. BACKGROUND OF THE INVENTION SUMMARY OF THE INVENTION 0002 The condition and appearance of skin degenerates 0007. The present invention is generally directed to an through the effects of environmental and other factors, such anti-aging composition. The anti-aging composition hereof as, for example, Sunlight, wind abrasion, humidity, pollut contains about 1 Vol.% retinol along with anti-irritant prop ants, diseases, and/or the normal aging process. Common erties. In particular, one embodiment of the anti-aging com problems for aging skin are the formation of wrinkles, fine position of the present invention includes a base, about 1 Vol lines, age spots, enlarged pores, blotchy skin discoloration, % retinol, at least one anti-irritant agent, at least one antioxi Surface roughness, loss of elasticity, and drooping skin. dant, at least one anti-inflammatory agent, and a moisturizing 0003) To prevent or repair the deterioration of skin quality complex. In another non-limiting illustration, the anti-aging that occurs over time, consumers have increasingly sought composition contains about 1% retinol, plantago lanceolata, new and/or improved products for skin care. Such products hypericum perforatum leaf extract, phytosphingosine, leon are designed to prevent, delay or reverse the visible signs of topodium alpinum extract, glycyrriza glabra root extract, the aging process. Such as the appearance of wrinkles and fine Sambucus migra flower extract, nordihydrognaiaretic acid, lines, loss of skin tone, thinning of the skin, hyperpigmenta oleanolic acid, spiraea ulmaria flower extract, evodia rutae tion or mottling, and age spots. These products may also carpa fruit extract, boswellia serrata extract, and additives. improve the appearance and condition of sensitive, dry or 0008. Other and further objects of the invention, together flaky skin, and may soothe skin that has been irritated by with the features of novelty appurtenant thereto, will appear exposure to chemicals, wind, or Sunlight, among other poten in the course of the following description. tial irritants. 0004. There are many different over-the-counter and pre DETAILED DESCRIPTION OF THE INVENTION Scription products available to treat the signs of aging and promote healthier skin. Some of these products contain ret 0009. There is provided herein a high potency topical ret inoic acid, a topical Vitamin A derivative that is available by inol anti-aging composition that provides intensive action prescription to treat the signs of aging. Retinol is also found in against the signs of aging while actively protecting against Some products to treat the signs of aging and is available redness, dryness and irritation. The anti-aging composition without a prescription. Retinoic acid is twenty percent stron hereof generally includes a base, about 1 vol% retinal, at least ger than retinol so to be effective a higher potency of retinol is one anti-irritant, at least one antioxidant, at least one anti used in over-the-counter products. However, most products inflammatory agent, and a moisturizing complex. It will be that contain retinoic acid or high potency retinol currently appreciated by those skilled in the art that Some agents dis available lead to inadequate results or have undesirable side closed throughout may have two or more properties. effects. These side effects may include, but not limited to, 0010. The composition of the present invention is irritation, redness, stinging, itching, blistering, burning, skin designed to maximize skin rejuvenation with the least pos Scaling, peeling and dryness of the skin, or more severe side sible side effects. In certain embodiments, the retinol is effects including, but not limited to, severe burning, itching, present in an amount of from about 0.001 to 20.0 vol% of the blistering, crusting, or Swelling of the skin, alterations in skin composition, more preferably from about 0.1 to 10.0 vol%. pigmentation, or aggravate eczema. By peeling of the top and most preferably from about 1.0 vol%. In one embodi layer of skin, retinoids may increase ones sensitivity to Sun ment, the composition contains the highest potency pure ret light. Irritation may also be aggravated by wind or cold, use of inol (1%) available to provide intensive action. In an alterna Soaps and cleansers, astringents, peeling agents and certain tive embodiment, the retinol is microencapsulated that results cosmetics. in a slow release to ensure greater bioavailability. 0005. Therefore, it would be beneficial to have a topical 0011. In one embodiment, the anti-aging composition skin care treatment that contains an effective amount of ret includes an effective amount of a base. In certain embodi inol to prevent or repair the effects of aging, reduces fine lines, ments, the base is present in an amount from about 0.01 to repairs skin discoloration, and rejuvenates the skin with the 99.9 vol% of the composition. Preferred bases include, but least possible side effects. It would also be beneficial to have are not limited to, lotions, creams, solutions, ointments, and a skin care treatment that contains high potency retinol that washes. also reduces harmful side effects. It would be further benefi 0012. In one embodiment, the anti-aging composition cial to have a topical skin care treatment that has an anti may also include an effective amount of an anti-irritant. In irritant complex to reduce the side effects and concerns asso certain embodiments, the anti-irritant is present in an amount ciated with the use of retinol. of from about 0.001 to 80.0 vol% of the composition, more 0006 Retinoids have been used extensively in the treat preferably from about 0.01 to 50.0 vol%, and most preferably ment of a variety of skin disorders and have been used as skin from about 0.1 to 5.0 vol%. In certain other embodiments, the repair or renewal agents. Topical retinoids are typically anti-irritant is plantago lanceolata, hypericum perforatum US 2011/0020414 A1 Jan. 27, 2011 leaf extract, phytosphingosine, derivatives thereof, or mix romycin, tetracycline, alpha hydroxyl acid, salicylic acid, tures thereof. Plantago lanceolata is a perennial found in the meadowsweet, curled dock (rumex Crispus), licorice extract, mountains of Switzerland containing properties that enhance acetaminophen, acetylsalicyclic acid, acetic acid, Zinc oxide, collagen production and wound healing and is both an anti Zinc sulfate, hydrocortisone, prednisone, methylpredniso oxidant and an anti-irritant. Hypericum perforatum leaf lone, prednisolone, white tea extract, green tea extract, caf extract also known as St. John's Wort is a source of powerful feine, tannin, isatsis indigotica root extract, menthol, irritation-soothing flavonoids including quercetin. Phytosph 18alpha-glcyrrhetinic acid, naproxen, 3-methyl-1-phenyl-2- ingosine is a naturally-occurring skin lipid with anti-redness pyrazolin-5-one, acacetin, acemetacin, aesculin, amcinonide, and skin firming properties. amiprilose, amygdalin, budesonide, bufeXamac, gynnest 0013. In one embodiment of the present invention, the emma, ebselen, enoXolone, esculin, etodolac, fenbufen, feno anti-aging composition also includes an effective amount of profen, flufenamic acid, flumethasone, flunisolide, fluocino an antioxidant. In certain embodiments, the antioxidant is lone acetonide, fluocinonide, fluorometholone, present in an amount of from about 0.001 to 80.0 vol% of the flurandrenolide, flurbiprofen, fosfosal, gentisic acid, guaia composition, more preferably from about 0.01 to 50.0 vol%. Zulene, halcinonide, hecogenin, hydrocortisone butyrate, ibu and most preferably from about 0.1 to 5.0 vol%. In certain profen, indomethacin, indoprofen, isoxicam, ketoprofen, other embodiments, the antioxidant is plantago lanceolata, ketorolac tromethamine, mefenamic acid, n-(9-fluorenyl leontopodium alpinum extract, glycyrriza glabra root extract, methoxycarbonyl-leucine, nabumetone, nifenaZone, niflumic Sambucus migra flower extract, derivates thereof, or mixtures acid, nimesulide, nordihydroguariaetic acid, DHT inhibitors, thereof. Leontopodium alpinum extract is an alpine flower spironolactone, drosperinone, finasteride, BCPS, partheno extract that has antioxidant and free radical-scavenging prop lide, oxypenbutaZone, picrolimus, ramiphenaZone, sodium erties. Glycyrriza glabra root extract also known as licorice dichlofenac, Sodium meclofenamate, Solasodine, Sulindac, root extract is an antioxidant with skin-Soothing properties. Suprofen, SuXibuZone, tacrolimus, tenoxicam, tolfenamic Sambucus nigra flower extract is an antioxidant rich in biofla acid, tripelennamine citrate, triprolidine hydrochloride, vonoids and anthocyanins. Zomepirac sodium, aspirin, beclomethasone dipropionate, 0014. In addition to the antioxidants named herein above, carbenoXolone sodium, celastrol, clobetasol propionate, dex other antioxidants suitable for use in the present composition amethasone acetate, dexamethasone sodium phosphate, include brompheniramine maleate, diclofenac, carbenox diclofenac, diflucortolone pivalate, diflunisal, fenspiride olone sodium, chlorpheniramine maleate, dexbromphe hydrochloride, hydrocortisone acetate, hydrocortisone niramine, diphenhydramine hydrochloride, diphenylpyraline hemisuccinate, phenylbutazone, piroxicam, pregnenolone, hydrochloride, doxylamine Succinate, cetirizine HCL, cin triamcinolone acetonide, triamcinolone benetonide, triamci narazine, chlorphenhydramine maleate, naphazoline hydro nolone diacetate, flutamide, cyproterone acetate, finasteride, chloride, pheniramine maleate, famotidine, flufenazine aminolevulinic acid HCL, Salix alba bark extract, hamamelis hydrochloride, ketotifen, omeprazole, pantoprazole Sodium, Virginiana distillate, antihistamines, derivatives thereof, and ranitidine, cimetidine, cyproheptadine, clemastine, hydrox mixtures thereof. yZine pamoate, doxepin HCL, loratadine, mebhydrolin naph 0017. In one embodiment of the present invention, the thalenesulfonate, methapyrilene hydrochloride, anti-aging composition also includes an effective amount of a orphenadrine citrate, pheniramine maleate, pyrilamine male moisturizing complex. In certain embodiments, the moistur ate, meclizine, quetiapine, ranitidine, terfenadine, thonzy izing complex is present in an amount of from about 0.001 to lamine hydrochloride, experimental H-3 and H-4 antagonists, 80.0 vol% of the composition, more preferably from about for example, ABT-239, cipralisant, ciproxifan, clobenpropit, 0.01 to 50.0 vol%, and most preferably from about 1.0 to 20.0 and thioperamide, derivatives thereof, and mixtures thereof. Vol.%. In certain other embodiments the moisturizing com 0015. In one embodiment of the present invention, the plex includes cyclomethicone, safflower seed oil, hyaluroulic anti-aging composition also includes an effective amount of acid, shea butter, glycerin, bisabolol, oat kernel extract, cera an anti-inflammatory agent. In certain embodiments, the anti mide-2, derivatives thereof, and mixtures thereof. The mois inflammatory agent is present in an amount of from about turizing complex establishes a protective barrier and inhibits 0.001 to 80.0 vol% of the composition, more preferably from dryness and peeling that may be associated with topical ret about 0.01 to 50.0 vol%, and most preferably from about 0.1 inol use. to 10.0 vol%. In certain other embodiments, the anti-inflam 0018. In certain embodiments, the anti-aging composition matory agent is nordihydrognaiaretic acid, oleanolic acid, may also include from about 0.01% to about 80.0% of an spiraea ulmaria flower extract, evodia rutaecarpa fruit additive such as fragrance, caprylic/capric triglyceride, glyc extract, boswellia serrata extract, derivates thereof, or mix erin, glyceryl acrylate, acrylic acid copolymer, cyclopentasi tures thereof. Nordihydrognaiaretic acid and oleanolic acid loxane, dimethicone crosspolymer, Stearic acid, glyceryl target redness while calming inflammation. Spiraea ulmaria Stearate, cyclomethicone, carthamus tinctorius (safflower) flower extract also known as meadowsweet has both anti seed oil, Stearyl alcohol, butyrospermum parkii (shea butter), inflammatory and antiseptic benefits. Evodia rutaecarpa fruit polysorbate 60, Sorbitol, phenoxyethanol, caprylyl glycol, extract also known as Wu Zhu Yu is a berry extract native to ethylhexyl glycerin, hexylene glycol, allyl methacrylates China shown to have a calming effect on inflammation in crosspolymer, polysorbate 20, butylene glycol, PEG-60 human skin. Boswellia serrata extract also known as Indian almond glycerides, carbomer, dimethicone, caffeine, bisab Frankincense has shown to have soothing effect on inflam olol, dipotassium glycyrrhizate, tea carbomer, sodium hyalu mation in human skin. ronate, sodium benzoate, potassium Sorbate, chamomilla 0016. In addition to the anti-inflammatory agents named recutita (chamomile) matricaria extract, cucumis sativus (cu hereinabove, other anti-inflammatory agents suitable for use cumber) fruit extract, ceramide 2, PEG-40 hydrogenated cas in the present composition include benzoyl peroxide, benzoyl tor oil, panax ginseng root extract, avena sativa (oat) kernel peroxide and clindamycin combinations, clindamycin, eryth extract, curcuma longa (turmeric) root extract, BHT malva US 2011/0020414 A1 Jan. 27, 2011
Sylvestris (mallow) flower extract, Salvia officinalis (sage) nursing. Fifty-five subjects were enrolled in the study and leaf extract, centella asiatica extract, leucine, Valine, fifty-three completed the study. The Subjects ranged in age tyrosine, arginine, and lysine. from eighteen to fifty-nine. The population demographics of 0019. In one embodiment, the anti-aging composition the study were seven males and forty-six females. hereof includes about 1.0% retinol, 5.0% caprylic/capric trig 0022 Test materials to be tested under occlusive condi lyceride, 3.5% glycerin, 3.5% glyceryl acrylate, 3.5% acrylic tions were placed on an 8-millimeter aluminum chamber acid copolymer, 3.5% cyclopentasiloxane, 3.5% dimethicone Supported on a sheet of occlusive tape or an equivalent crosspolymer, 3.25% stearic acid, 2.5% glyceryl Stearate, thereof. Test materials to be tested under semi-occlusive con 2.5% cyclomethicone, 2.0% carthamus tinctorius (safflower) ditions were placed on sensitive skin bandages. Test materials seed oil, 1.75% stearyl alcohol, 1.5% butyrospermum parkii to be tested in an open patch were applied and rubbed directly (shea butter), 1.5% polysorbate 60, 1.0% sorbitol, 1.0% phe noxyethanol, 1.0% caprylyl glycol, 1.0% ethylhexyl glyc onto the back of the subject. Approximately 0.02-0.05 mL (in erin, 1.0% hexylene glycol, 1.0% allyl methacrylates cross case of liquids) and/or 0.02-0.05gm (in case of solids) of the polymer, 1.0% polysorbate 20, 0.5% butylene glycol, 0.5% test material was used for the study. Liquid test material was PEG-60 almond glycerides, 0.5% carbomer, 0.5% nordihy dispensed on a 7.5 mm paper disk that fit in the aluminum droguaiaretic acid, 0.5% oleanolic acid, 0.5% dimethicone, chamber. 0.5% phytosphingosine, 0.5% caffeine, 0.5% bisabolol, 0.5% 0023 The following procedure was followed by the sub dipotassium glycyrrhizate, 0.5% tea carbomer, 0.5% sodium jects. Subjects were requested to bathe or wash as usual hyaluronate, 0.25% leontopodium alpinum (edelweiss) before arrival at the facility. Patches containing the test mate extract, 0.25% plantago lanceolata leaf extract, 0.25% rial were then affixed directly to the skin of the intrascapular sodium benzoate, 0.25% potassium sorbate, 0.1% evodia regions of the back, to the right or left of the midline, and rutaecarpa fruit extract, 0.1% boswellia serrata extract, 0.1% subjects were dismissed with instructions not to wet the test glycyrrhiza glabra (licorice) root extract, 0.1% chamomilla area or expose it to direct Sunlight. Subjects were instructed to recutita (chamomile) matricaria extract, 0.1% cucumis Sati remove the patches approximately 24 hours after application. vus (cucumber) fruit extract, 0.1% ceramide 2, 0.1% PEG-40 This procedure was repeated until a series of nine (9) con hydrogenated castor oil, 0.1% panax ginseng root extract, secutive, 24-hour exposures had been made three (3) times a 0.1% avena sativa (oat) kernel extract, 0.1% curcuma longa week for three (3) consecutive weeks. Prior to each reappli (turmeric) root extract, 0.1% BHT, 0.1% hypericum perfora cation, the test sites were evaluated by trained laboratory tum (St. John's Wort) leaf extract, 0.1% malva Sylvestris personnel. Following a 10-14 day rest period, a retest/chal (mallow) flower extract, 0.1% salvia officinalis (sage) leaf extract, 0.1% Sambucus migra (elderberry) flower extract, lenge dose was applied once to a previously unexposed test 0.1% spiraea ulmaria (meadowsweet) flower extract, 0.1% site. Test sites were evaluated by trained laboratory personnel centella asiatica extract, 0.1% leucine, 0.1% valine, 0.1% 48 and 96 hours after application. In the event of an adverse tyrosine, 0.1% arginine, 0.1% lysine, and deionized water. reaction, the area of erythema and edema were measured. 0020) Clinical Study Edema is estimated by the evaluation of the skin with respect to the contour of the unaffected normal skin. Subjects were 0021 One embodiment of the present invention was clini cally tested to demonstrate that a user, having applied the instructed to report any delayed reactions that might occur composition to the skin, developed few, if any, side effects after the final reading. even though the composition contained about 1% retinol. The 0024. The following scoring system was used and the standards used for inclusion in the study included individuals scoring scale and definition of symbols shown below are who were not currently under a doctor's care; individuals who based on the scoring scheme according to the International were free of any dermatological or systemic disorder that Contact Dermatitis Research Group (ICDRG)'''''''" would interfere with the results; individuals who were free of tis, Dernatology, Volume 1, 2nd edition, by S. Moscheiia MD, H Hitriev MD, any acute or chronic disease that would interfere with or WB Saunders, Company, 1985. increase the risk of study participation; individuals who com 0025 0 No visible reaction, doubtful reaction pleted a preliminary medical history form mandated by BCS 0026 1 A weak (nonvesicular) reactions showing mild and were in generally good health; individuals who read, erythema (redness) and possible papules (Small elevated understood and signed an informed consent document relat lesions, granular feeling) ing to the specific type of study; and individuals who were 0027 2 A strong reaction (moderate erythema) with able to cooperate with the investigator and research staff, vesicles (small elevated lesions that are fluid filled, <=5 were willing to have test materials applied according to the mm) study protocol, and completed the full course of the study. 0028 3 Severe (bright red) erythema with extreme blister The standards for exclusion from the study were individuals ing who were under 18 years of age; individuals who were cur rently under a doctor's care; individuals who were currently 0029) D Site discontinued taking any medication (topical or systemic) that might mask 0.030 Dc Subject discontinued or interfere with the test results; individuals who had a history NOTE: Clinical evaluations were performed by a BCS inves of any acute or chronic disease that might interfere with or tigator or designee trained in the clinical evaluation of the increase the risk associated with study participation; indi skin. Whenever feasible, the same individual conducted the viduals who were diagnosed with chronic skin allergies; and scoring of all the Subjects throughout the study and was female volunteers who indicated that they were pregnant or blinded to the treatment assignments and any previous scores. US 2011/0020414 A1 Jan. 27, 2011
0.031 A summary of the results is shown in Table 1:
TABLE 1.
Subject Information Induction Challenge
No. ID Sex Age Race 1 2
49 31 52 22 51 18 43 18 9 O9 M 36 10 10 31 11 11 38 12 12 M 33 13 13 37 14 14 40 15 15 29 16 16 27 17 17 18 18 25 19 19 31 2O 21 49 21 22 47 22 23 S4 23 24 42 24 25 M 36 25 26 22 26 27 58 27 28 36 28 30 58 29 31 M 25 30 32 27 31 33 28 32 34 27 33 35 25 34 36 37 35 37 34 36 38 59 37 39 50 38 40 43 39 41 40 40 42 43 41 43 31 42 44 32 43 45 40 44 46 50 45 47 23 46 48 18 47 49 30 48 50 53 49 30 50 52 41 51 5.3 M 41 52 21 53 55 M 22 US 2011/0020414 A1 Jan. 27, 2011
0032. The clinical study provided the observation that tylsalicyclic acid, acetic acid, Zinc oxide, Zinc sulfate, hydro there were no adverse reactions of any kind reported during cortisone, prednisone, methylpredisolone, prednisolone, the course of the study. The study concluded that, under the white tea extract, green tea extract, caffeine, tannin, isatsis conditions of the study, there were no identifiable signs or indigotica root extract, menthol, 18alpha-glcyrrhetinic acid, symptoms of sensitization (contact allergy) noted for the 1% naproxen, 3-methyl-1-phenyl-2-pyrazolin-5-one, acacetin, retinol cream tested. acemetacin, aesculin, amcinonide, amiprilose, amygdalin, 0033. From the foregoing, it will be seen that this inven budesonide, bufexamac, gynneStemma, ebselen, enoXolone, tion is one well adapted to attain all ends and objects herein esculin, etodolac, fenbufen, fenoprofen, flufenamic acid, flu above set forth together with the other advantages which are methasone, flunisolide, fluocinolone acetonide, fluocinonide, obvious and which are inherent to the composition. It will be fluorometholone, flurandrenolide, flurbiprofen, fosfosal, understood that certain features and Subcombinations are of gentisic acid, guaiaZulene, halcinonide, hecogenin, hydrocor utility and may be employed without reference to other fea tisone butyrate, ibuprofen, indomethacin, indoprofen, isoxi tures and Subcombinations. This is contemplated by and is cam, ketoprofen, ketorolac tromethamine, mefenamic acid, within the scope of the claims. Since many possible embodi n-(9-fluorenylmethoxycarbonyl)-1-leucine, nabumetone, ments may be made of the invention without departing from nifenaZone, niflumic acid, nimeSulide, nordihydroguaiaretic the scope thereof, it is to be understood that all matter herein acid, DHT inhibitors, spironolactone, drosperinone, finas set forth is to be interpreted as illustrative, and not in a limiting teride, BCPS, parthenolide, oxypenbutazone, picrolimus, SSC. ramiphenaZone, Sodium dichlofenac, Sodium meclofe What is claimed is: namate, Solasodine, Sulindac, Suprofen, SuXibuZone, tacroli 1. A topical anti-aging composition comprising: mus, tenoxicam, tolfenamic acid, tripelennamine citrate, a base; triprolidine hydrochloride, Zomepirac sodium, aspirin, from about 0.001 to 20.0 vol% retinol: beclomethasone dipropionate, carbenoXolone sodium, cellas at least one anti-irritant; trol, clobetasol propionate, dexamethasone acetate, dexam at least one antioxidant; ethasone sodium phosphate, diclofenac, diflucortolone piv at least one anti-inflammatory agent; and alate, diflunisal, fenspiride hydrochloride, hydrocortisone a moisturizing complex. acetate, hydrocortisone hemisuccinate, phenylbutaZone, 2. The composition of claim 1 wherein said base is selected piroXicam, pregnenolone, triamcinolone acetonide, triamci from a group consisting of lotions, creams, solutions, oint nolone benetonide, triamcinolone diacetate, flutamide, ments, washes, and combinations thereof. cyproterone acetate, finasteride, aminolevulinic acid HCL, 3. The composition of claim 1 wherein said retinol com Salix alba bark extract, hamamelis Virginiana distillate, anti prises about 1.0 vol% of said composition. histamines, derivatives thereof, and mixtures thereof. 4. The composition of claim 1 wherein said retinol is 8. The composition of claim 1 wherein said moisturizing microencapsulated. complex comprises cyclomethicone, safflower seed oil, 5. The composition of claim 1 wherein said anti-irritant is hyaluroulic acid, shea butter, glycerin, bisabolol, oat kernel selected from a group consisting of plantago lanceolata, extract, and ceranuid-2. hypericum perforatum leaf extract, phytosphingosine, deriva 9. The composition of claim 1 comprising at least one tives thereof, and mixtures thereof. additive. 6. The composition of claim 1 wherein said antioxidant is 10. The composition of claim 9 wherein said additive is selected from a group consisting of plantago lanceolata, selected from a group consisting of fragrance, caprylic/capric leontopodium alpinum extract, glycyrriza glabra root extract, triglyceride, glycerin, glyceryl acrylate, acrylic acid copoly Sambucus migra flower extract, brompheniramine maleate, mer, cyclopentasiloxane, dimethicone crosspolymer, Stearic diclofenac, carbenoXolone sodium, chlorpheniramine male acid, glyceryl Stearate, cyclomethicone, carthamus tinctorius ate, dexbrompheniramine, diphenhydramine hydrochloride, (safflower) seed oil, Stearyl alcohol, butyrospermum parkii diphenylpyraline hydrochloride, doxylamine Succinate, ceti (shea butter), polysorbate 60, sorbitol, phenoxyethanol, rizine HCL, cinnarazine, chlorphenhydramine maleate, nap caprylyl glycol, ethylhexyl glycerin, hexylene glycol, allyl haZoline hydrochloride, pheniramine maleate, famotidine, methacrylates crosspolymer, polysorbate 20, butylene glycol, flufenazine hydrochloride, ketotifen, omeprazole, pantopra PEG-60 almond glycerides, carbomer, dimethicone, caffeine, Zole Sodium, ranitidine, cimetidine, cyproheptadine, clemas bisabolol, dipotassium glycyrrhizate, tea carbomer, sodium tine, hydroxy Zine pamoate, doxepin HCL, loratadine, meb hyaluronate, Sodium benzoate, potassium Sorbate, chamo hydrolin naphthalenesulfonate, methapyrilene milla recutita (chamomile) matricaria extract, cucumis Sati hydrochloride, orphenadrine citrate, pheniramine maleate, vus (cucumber) fruit extract, ceramide 2, PEG-40 hydroge pyrilamine maleate, meclizine, quetiapine, ranitidine, ter nated castor oil, panaxginseng root extract, avena sativa (oat) fenadine, thonzylamine hydrochloride, experimental H-3 and kernel extract, curcuna longa (turmeric) root extract, BHT, H-4 antagonists, for example, ABT-239, cipralisant, ciproxi malva Sylvestris (mallow) flower extract, Salvia officinalis fan, clobempropit, and thioperamide, derivatives thereof, and (sage) leaf extract, centella asiatica extract, leucine, Valine, mixtures thereof. tyrosine, arginine, and lysine. 7. The composition of claim 1 wherein said anti-inflam 11. A topical anti-aging composition comprising: matory agent is selected from a group consisting of nordihy drognaiaretic acid, oleanolic acid, spiraea ulmaria flower a base, wherein said base is selected from a group consist extract, evodia rutaecarpa fruit extract, boswellia serrata ing oflotions, creams, Solutions, ointments, washes and extract, benzoyl peroxide, benzoyl peroxide and clindamycin combinations thereof; combinations, clindamycin, erythromycin, tetracycline, from about 0.001 to 20.0 vol% retinol: alpha hydroxyl acid, salicylic acid, meadowsweet, curled at least one anti-irritant, wherein said anti-irritant is dock (rumex crispus), licorice extract, acetaminophen, ace Selected from a group consisting of plantago lanceolata, US 2011/0020414 A1 Jan. 27, 2011
hypericum perforatum leaf extract, phytosphingosine, 17. A topical anti-aging composition comprising: derivatives thereof, and mixtures thereof; a base, wherein said base is selected from a group consist ing oflotions, creams, Solutions, ointments, washes and at least one antioxidant, wherein said antioxidant is combinations thereof; Selected from a group consisting of plantago lanceolata, about 1 vol% retinol, wherein said retinol is microencap leontopodium alpinum extract, glycyrriza glabra root Sulated; extract, Sambucus nigra flower extract, derivatives at least one anti-irritant, wherein said anti-irritant is thereof, and mixtures thereof; Selected from a group consisting of plantago lanceolata, at least one anti-inflammatory agent, wherein said anti hypericum perforatum leaf extract, phytosphingosine, inflammatory agent is selected from a group consisting derivatives thereof, and mixtures thereof: of nordihydrognaiaretic acid, oleanolic acid, spiraea at least one antioxidant, wherein said antioxidant is Selected from a group consisting of plantago lanceolata, ulmaria flower extract, evodia rutaecarpa fruit extract, leontopodium alpinum extract, glycyrriza glabra root boswellia serrata extract, derivatives thereof, and mix extract, Sambucus nigra flower extract, derivatives tures thereof, and thereof, and mixtures thereof; a moisturizing complex. at least one anti-inflammatory agent, wherein said anti 12. The composition of claim 1 wherein said retinol com inflammatory agent is selected from a group consisting prises about 1.0 vol% of said composition. of nordihydrognaiaretic acid, oleanolic acid, spiraea 13. The composition of claim 11 wherein said retinol is ulmaria flower extract, evodia rutaecarpa fruit extract, microencapsulated. boswellia serrata extract, derivatives thereof, and mix tures thereof, and 14. The composition of claim 11 wherein said moisturizing a moisturizing complex, wherein said moisturizing com complex comprises cyclomethicone, safflower seed oil, plex comprises cyclomethicone, Safflower seed oil, hyaluroulic acid, shea butter, glycerin, bisabolol, oat kernel hyaluroulic acid, shea butter, glycerin, bisabolol, oat ker extract, and ceramide-2. nel extract, and ceramide-2. 15. The composition of claim 11 comprising at least one 18. The composition of claim 17 comprising at least one additive. additive, wherein said additive is selected from a group con 16. The composition of claim 15 wherein said additive is sisting of fragrance, caprylic/capric triglyceride, glycerin, selected from a group consisting of fragrance, caprylic?capric glyceryl acrylate, acrylic acid copolymer, cyclopentasilox triglyceride, glycerin, glyceryl acrylate, acrylic acid copoly ane, dimethicone crosspolymer, Stearic acid, glyceryl Stear ate, cyclomethicone, carthamus tinctorius (safflower) seed mer, cyclopentasiloxane, dimethicone crosspolymer, Stearic oil, Stearyl alcohol, butyrospermum parkii (shea butter), acid, glyceryl Stearate, cyclomethicone, carthamus tinctorius polysorbate 60, Sorbitol, phenoxyethanol, caprylyl glycol, (safflower) seed oil, Stearyl alcohol, butyrospermum parkii ethylhexyl glycerin, hexylene glycol, allyl methacrylates (shea butter), polysorbate 60, sorbitol, phenoxyethanol, crosspolymer, polysorbate 20, butylene glycol, PEG-60 caprylyl glycol, ethylhexyl glycerin, hexylene glycol, allyl almond glycerides, carbomer, dimethicone, caffeine, bisab methacrylates crosspolymer, polysorbate 20, butylene glycol, olol, dipotassium glycyrrhizate, tea carbomer, sodium hyalu PEG-60 almond glycerides, carbomer, dimethicone, caffeine, ronate, sodium benzoate, potassium Sorbate, chamomilla bisabolol, dipotassium glycyrrhizate, tea carbomer, sodium recutita (chamomile) matricaria extract, cucumis sativus (cu hyaluronate, Sodium benzoate, potassium Sorbate, chamo cumber) fruit extract, ceramide 2, PEG-40 hydrogenated cas milla recutita (chamomile) matricaria extract, cucumis Sati tor oil, panax ginseng root extract, avena sativa (oat) kernel vus (cucumber) fruit extract, ceramide 2, PEG-40 hydroge extract, curcuma Tonga (turmeric) root extract, BHT malva nated castor oil, panaxginseng root extract, avena sativa (oat) Sylvestris (mallow) flower extract, Salvia officinalis (sage) kernel extract, curcuna longa (turmeric) root extract, BHT, leaf extract, centella asiatica extract, leucine, Valine, malva Sylvestris (mallow) flower extract, Salvia officinalis tyrosine, arginine, and lysine. (sage) leaf extract, centella asiatica extract, leucine, Valine, tyrosine, arginine, and lysine. c c c c c