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OptumRx - DE Medicaid MAC List Effective as of 1/5/2018 Generic Label Name & Drug Strength Effective Date MAC Price OTHER IV THERAPY (OTIP) 10/25/2017 77.61750 PENICILLIN G POTASSIUM FOR INJ 5000000 UNIT 3/15/2017 8.00000 PENICILLIN G POTASSIUM FOR INJ 20000000 UNIT 3/15/2017 49.62000 PENICILLIN G SODIUM FOR INJ 5000000 UNIT 10/25/2017 53.57958 PENICILLIN V POTASSIUM TAB 250 MG 1/3/2018 0.05510 PENICILLIN V POTASSIUM TAB 500 MG 12/29/2017 0.10800 PENICILLIN V POTASSIUM FOR SOLN 125 MG/5ML 10/26/2017 0.02000 PENICILLIN V POTASSIUM FOR SOLN 250 MG/5ML 12/22/2017 0.02000 AMOXICILLIN (TRIHYDRATE) CAP 250 MG 12/22/2017 0.03930 AMOXICILLIN (TRIHYDRATE) CAP 500 MG 11/1/2017 0.05000 AMOXICILLIN (TRIHYDRATE) TAB 500 MG 12/28/2017 0.20630 AMOXICILLIN (TRIHYDRATE) TAB 875 MG 10/31/2017 0.08000 AMOXICILLIN (TRIHYDRATE) CHEW TAB 125 MG 10/26/2017 0.12000 AMOXICILLIN (TRIHYDRATE) CHEW TAB 250 MG 10/26/2017 0.24000 AMOXICILLIN (TRIHYDRATE) FOR SUSP 125 MG/5ML 10/28/2017 0.00667 AMOXICILLIN (TRIHYDRATE) FOR SUSP 200 MG/5ML 12/20/2017 0.01240 AMOXICILLIN (TRIHYDRATE) FOR SUSP 250 MG/5ML 12/18/2017 0.00980 AMOXICILLIN (TRIHYDRATE) FOR SUSP 400 MG/5ML 12/28/2017 0.01310 AMPICILLIN CAP 250 MG 9/26/2017 0.07154 AMPICILLIN CAP 500 MG 11/6/2017 0.24000 AMPICILLIN FOR SUSP 125 MG/5ML 3/17/2017 0.02825 AMPICILLIN FOR SUSP 250 MG/5ML 9/15/2017 0.00491 AMPICILLIN SODIUM FOR INJ 250 MG 3/15/2017 1.38900 AMPICILLIN SODIUM FOR INJ 500 MG 7/16/2016 1.02520 AMPICILLIN SODIUM FOR INJ 1 GM 12/20/2017 2.00370 AMPICILLIN SODIUM FOR IV SOLN 1 GM 7/16/2016 15.76300 AMPICILLIN SODIUM FOR INJ 2 GM 7/16/2016 4.69480 AMPICILLIN SODIUM FOR IV SOLN 2 GM 3/15/2017 7.55300 AMPICILLIN SODIUM FOR INJ 10 GM 7/16/2016 43.01000 AMPICILLIN SODIUM FOR IV SOLN 10 GM 7/16/2016 36.02500 DICLOXACILLIN SODIUM CAP 250 MG 12/20/2017 0.32220 DICLOXACILLIN SODIUM CAP 500 MG 12/29/2017 0.59680 NAFCILLIN SODIUM FOR INJ 1 GM 7/16/2016 6.26120 NAFCILLIN SODIUM FOR INJ 2 GM 9/16/2016 11.48520 NAFCILLIN SODIUM FOR IV SOLN 2 GM 12/15/2015 37.13028 NAFCILLIN SODIUM FOR INJ 10 GM 7/16/2016 84.48759 OXACILLIN SODIUM FOR INJ 1 GM (BASE EQUIVALENT) 3/15/2017 8.00000 OXACILLIN SODIUM FOR INJ 2 GM (BASE EQUIVALENT) 3/15/2017 16.00000 OXACILLIN SODIUM FOR INJ 10 GM (BASE EQUIVALENT) 3/15/2017 87.30000 AMOXICILLIN & K CLAVULANATE TAB 250-125 MG 12/29/2017 3.85230 AMOXICILLIN & K CLAVULANATE TAB 500-125 MG 11/1/2017 0.15600 AMOXICILLIN & K CLAVULANATE TAB 875-125 MG 12/18/2017 0.33780 AMOXICILLIN & K CLAVULANATE CHEW TAB 200-28.5 MG 10/12/2017 0.88661 AMOXICILLIN & K CLAVULANATE CHEW TAB 400-57 MG 12/22/2017 2.11880 AMOXICILLIN & K CLAVULANATE FOR SUSP 200-28.5 MG/5ML 12/28/2017 0.04190 AMOXICILLIN & K CLAVULANATE FOR SUSP 250-62.5 MG/5ML 10/28/2017 0.39333 AMOXICILLIN & K CLAVULANATE FOR SUSP 400-57 MG/5ML 12/29/2017 0.06230 AMOXICILLIN & K CLAVULANATE FOR SUSP 600-42.9 MG/5ML 10/31/2017 0.07500 AMOXICILLIN & K CLAVULANATE TAB ER 12HR 1000-62.5 MG 10/26/2017 4.14286 AMPICILLIN & SULBACTAM SODIUM FOR INJ 1.5 (1-0.5) GM 3/15/2017 2.11220 AMPICILLIN & SULBACTAM SODIUM FOR INJ 3 (2-1) GM 7/16/2016 3.93910 AMPICILLIN & SULBACTAM SODIUM FOR INJ 15 (10-5) GM 3/15/2017 16.23000 AMPICILLIN & SULBACTAM SODIUM FOR IV SOLN 15 (10-5) GM 3/15/2017 16.15000 PIPERACILLIN SOD-TAZOBACTAM SOD FOR INJ 2.25 GM (2-0.25 GM) 9/15/2017 1.31111 PIPERACILLIN SOD-TAZOBACTAM NA FOR INJ 3.375 GM (3-0.375 GM) 5/25/2017 4.03920 PIPERACILLIN SOD-TAZOBACTAM SOD FOR INJ 4.5 GM (4-0.5 GM) 5/17/2017 5.61000 PIPERACILLIN SOD-TAZOBACTAM SOD FOR INJ 13.5 GM (12-1.5 GM) 10/25/2017 61.96500 PIPERACILLIN SOD-TAZOBACTAM SOD FOR INJ 40.5 GM (36-4.5 GM) 3/15/2017 80.25940 CEFADROXIL CAP 500 MG 12/28/2017 0.17750 CEFADROXIL TAB 1 GM 12/20/2017 1.71910 CEFADROXIL FOR SUSP 250 MG/5ML 12/20/2017 0.17000 CEFADROXIL FOR SUSP 500 MG/5ML 10/26/2017 0.26000 CEFAZOLIN SODIUM FOR INJ 500 MG 9/2/2017 1.35262 CEFAZOLIN SODIUM FOR INJ 1 GM 8/25/2017 0.80825 CEFAZOLIN SODIUM FOR IV SOLN 1 GM 10/25/2017 2.76624 CEFAZOLIN SODIUM FOR INJ 10 GM 7/16/2016 6.13690 CEFAZOLIN IN D5W INJ 1 GM/50ML 7/16/2016 0.12320 CEFAZOLIN SODIUM-DEXTROSE IV SOLUTION 2 GM/100ML-4% 3/15/2017 0.09250 CEFAZOLIN SODIUM FOR IV SOLN 1 GM AND DEXTROSE 4% 10/25/2017 4.19815 CEFAZOLIN SODIUM FOR IV SOLN 2 GM AND DEXTROSE 3% 3/15/2017 7.15417 CEPHALEXIN CAP 250 MG 12/29/2017 0.05080 CEPHALEXIN CAP 500 MG 10/31/2017 0.06800 CEPHALEXIN CAP 750 MG 10/26/2017 4.75000 CEPHALEXIN TAB 250 MG 10/26/2017 0.92000 CEPHALEXIN TAB 500 MG 10/26/2017 1.84000 CEPHALEXIN FOR SUSP 125 MG/5ML 10/26/2017 0.09000 CEPHALEXIN FOR SUSP 250 MG/5ML 11/4/2017 0.09500 CEFACLOR CAP 250 MG 10/26/2017 0.41290 CEFACLOR CAP 500 MG 10/26/2017 0.76130 CEFACLOR FOR SUSP 250 MG/5ML 7/14/2017 1.16620 CEFACLOR MONOHYDRATE TAB ER 12HR 500 MG 7/16/2016 10.80090 CEFOTETAN DISODIUM FOR INJ 1 GM 3/15/2017 19.22000 CEFOTETAN DISODIUM FOR INJ 2 GM 3/15/2017 37.60000 CEFOXITIN SODIUM FOR IV SOLN 1 GM 3/15/2017 3.95000 CEFOXITIN SODIUM FOR IV SOLN 2 GM 7/16/2016 6.60000 CEFOXITIN SODIUM FOR INJ 10 GM 3/15/2017 27.50000 CEFPROZIL TAB 250 MG 12/28/2017 0.56590 CEFPROZIL TAB 500 MG 11/27/2017 0.86000 CEFPROZIL FOR SUSP 125 MG/5ML 12/28/2017 0.11070 CEFPROZIL FOR SUSP 250 MG/5ML 12/29/2017 0.18860 CEFUROXIME AXETIL TAB 250 MG 12/19/2017 0.55000 CEFUROXIME AXETIL TAB 500 MG 11/1/2017 0.95000 CEFUROXIME SODIUM FOR INJ 750 MG 7/16/2016 2.40064 CEFUROXIME SODIUM FOR INJ 1.5 GM 7/16/2016 3.82800 CEFUROXIME SODIUM FOR IV SOLN 1.5 GM 7/14/2017 4.98127 CEFUROXIME SODIUM FOR INJ 7.5 GM 3/15/2017 19.40000 CEFDINIR CAP 300 MG 12/18/2017 0.35250 CEFDINIR FOR SUSP 125 MG/5ML 10/31/2017 0.15000 CEFDINIR FOR SUSP 250 MG/5ML 11/3/2017 0.20000 CEFIXIME FOR SUSP 100 MG/5ML 10/28/2017 2.70000 CEFIXIME FOR SUSP 200 MG/5ML 10/26/2017 5.27000 CEFPODOXIME PROXETIL TAB 100 MG 10/26/2017 3.75000 CEFPODOXIME PROXETIL TAB 200 MG 10/26/2017 4.00000 CEFPODOXIME PROXETIL FOR SUSP 50 MG/5ML 5/25/2017 0.59180 CEFPODOXIME PROXETIL FOR SUSP 100 MG/5ML 10/26/2017 0.96000 CEFOTAXIME SODIUM FOR INJ 500 MG 3/15/2017 1.45500 CEFOTAXIME SODIUM FOR INJ 1 GM 7/16/2016 1.57300 CEFOTAXIME SODIUM FOR INJ 2 GM 3/15/2017 3.28280 CEFOTAXIME SODIUM FOR INJ 10 GM 7/16/2016 19.88800 CEFTAZIDIME FOR INJ 1 GM 11/23/2017 3.80000 CEFTAZIDIME FOR IV SOLN 1 GM 3/15/2017 5.36000 CEFTAZIDIME FOR INJ 2 GM 3/15/2017 8.45000 CEFTAZIDIME FOR IV SOLN 2 GM 3/15/2017 10.89000 CEFTAZIDIME FOR INJ 6 GM 7/16/2016 18.65600 CEFTAZIDIME FOR IV SOLN 1 GM/50ML AND DEXTROSE 5% 10/25/2017 11.74020 CEFTAZIDIME FOR IV SOLN 2 GM/50ML AND DEXTROSE 5% 3/15/2017 16.08750 CEFTIBUTEN CAP 400 MG 2/17/2017 20.40510 CEFTIBUTEN FOR SUSP 180 MG/5ML 10/26/2017 6.20250 CEFTRIAXONE SODIUM FOR INJ 250 MG 10/26/2017 0.71000 CEFTRIAXONE SODIUM FOR INJ 500 MG 10/26/2017 0.90000 CEFTRIAXONE SODIUM FOR INJ 1 GM 12/29/2017 1.49560 CEFTRIAXONE SODIUM FOR IV SOLN 1 GM 5/25/2017 3.80460 CEFTRIAXONE SODIUM FOR INJ 2 GM 12/28/2017 2.00000 CEFTRIAXONE SODIUM FOR IV SOLN 2 GM 3/15/2017 6.84000 CEFTRIAXONE SODIUM FOR INJ 10 GM 7/16/2016 19.56614 CEFTRIAXONE SODIUM (BULK) FOR INJ 100 GM 10/25/2017 739.50000 CEFTRIAXONE SODIUM IN DEXTROSE INJ 20 MG/ML 7/16/2016 0.39023 CEFTRIAXONE SODIUM IN DEXTROSE INJ 40 MG/ML 3/15/2017 1.50580 CEFTRIAXONE SODIUM FOR IV SOLN 1 GM AND DEXTROSE 3.74% 10/25/2017 13.48865 CEFTRIAXONE SODIUM FOR IV SOLN 2 GM AND DEXTROSE 2.22% 3/15/2017 20.76667 CEFEPIME HCL IV SOLN 1 GM/50ML 10/25/2017 0.67728 CEFEPIME HCL IV SOLN 2 GM/100ML 10/25/2017 0.54290 CEFEPIME HCL FOR INJ 1 GM 9/15/2017 1.16096 CEFEPIME HCL FOR INJ 2 GM 2/17/2017 6.47190 CEFEPIME HCL AND DEXTROSE 5% FOR IV SOLN 1 GM/50ML 10/25/2017 13.17458 CEFEPIME HCL AND DEXTROSE 5% FOR IV SOLN 2 GM/50ML 10/25/2017 19.52365 ERYTHROMYCIN TAB 250 MG 12/29/2017 11.37220 ERYTHROMYCIN TAB 500 MG 5/25/2017 15.91088 ERYTHROMYCIN W/ DELAYED RELEASE PARTICLES CAP 250 MG 12/29/2017 4.23210 ERYTHROMYCIN ETHYLSUCCINATE TAB 400 MG 11/23/2017 11.93000 ERYTHROMYCIN ETHYLSUCCINATE FOR SUSP 200 MG/5ML 10/31/2017 2.15000 AZITHROMYCIN TAB 250 MG 11/24/2017 0.33333 AZITHROMYCIN TAB 500 MG 12/28/2017 0.72410 AZITHROMYCIN TAB 600 MG 12/29/2017 1.68620 AZITHROMYCIN FOR SUSP 100 MG/5ML 11/3/2017 0.53000 AZITHROMYCIN FOR SUSP 200 MG/5ML 11/11/2017 0.26733 AZITHROMYCIN IV FOR SOLN 500 MG 2/17/2017 3.29664 AZITHROMYCIN POWD PACK FOR SUSP 1 GM 10/28/2017 18.66667 CLARITHROMYCIN TAB 250 MG 12/29/2017 0.43270 CLARITHROMYCIN TAB 500 MG 12/18/2017 0.48980 CLARITHROMYCIN FOR SUSP 125 MG/5ML 10/26/2017 0.38000 CLARITHROMYCIN FOR SUSP 250 MG/5ML 11/16/2017 0.86000 CLARITHROMYCIN TAB ER 24HR 500 MG 10/26/2017 2.78333 DEMECLOCYCLINE HCL TAB 150 MG 10/26/2017 1.63110 DEMECLOCYCLINE HCL TAB 300 MG 10/26/2017 3.04396 DOXYCYCLINE MONOHYDRATE CAP 50 MG 12/21/2017 0.13880 DOXYCYCLINE MONOHYDRATE CAP 75 MG 10/28/2017 9.13000 DOXYCYCLINE MONOHYDRATE CAP 100 MG 11/4/2017 0.22000 DOXYCYCLINE MONOHYDRATE CAP 150 MG 11/23/2017 1.18950 DOXYCYCLINE MONOHYDRATE TAB 50 MG 12/29/2017 0.37240 DOXYCYCLINE MONOHYDRATE TAB 75 MG 10/26/2017 0.47760 DOXYCYCLINE MONOHYDRATE TAB 100 MG 12/28/2017 0.37400 DOXYCYCLINE MONOHYDRATE TAB 150 MG 12/29/2017 4.71890 DOXYCYCLINE MONOHYDRATE FOR SUSP 25 MG/5ML 10/26/2017 0.23333 DOXYCYCLINE HYCLATE CAP 50 MG 10/26/2017 0.42000 DOXYCYCLINE HYCLATE CAP 100 MG 12/19/2017 0.26040 DOXYCYCLINE HYCLATE TAB 20 MG 12/17/2017 0.31000 DOXYCYCLINE HYCLATE TAB 75 MG 11/21/2017 10.06667 DOXYCYCLINE HYCLATE TAB 100 MG 10/31/2017 0.32000 DOXYCYCLINE HYCLATE TAB 150 MG 12/12/2017 13.98333 DOXYCYCLINE HYCLATE TAB DELAYED RELEASE 50 MG 10/26/2017 8.35833 DOXYCYCLINE HYCLATE TAB DELAYED RELEASE 75 MG 11/23/2017 5.83000 DOXYCYCLINE HYCLATE TAB DELAYED RELEASE 100 MG 10/26/2017 5.50000 DOXYCYCLINE HYCLATE TAB DELAYED
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    European Journal of Endocrinology (2000) 143 687±695 ISSN 0804-4643 EXPERIMENTAL STUDY Opposing effects of dehydroepiandrosterone and dexamethasone on the generation of monocyte-derived dendritic cells M O Canning, K Grotenhuis, H J de Wit and H A Drexhage Department of Immunology, Erasmus University Rotterdam, The Netherlands (Correspondence should be addressed to H A Drexhage, Lab Ee 838, Department of Immunology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands; Email: [email protected]) Abstract Background: Dehydroepiandrosterone (DHEA) has been suggested as an immunostimulating steroid hormone, of which the effects on the development of dendritic cells (DC) are unknown. The effects of DHEA often oppose those of the other adrenal glucocorticoid, cortisol. Glucocorticoids (GC) are known to suppress the immune response at different levels and have recently been shown to modulate the development of DC, thereby influencing the initiation of the immune response. Variations in the duration of exposure to, and doses of, GC (particularly dexamethasone (DEX)) however, have resulted in conflicting effects on DC development. Aim: In this study, we describe the effects of a continuous high level of exposure to the adrenal steroid DHEA (1026 M) on the generation of immature DC from monocytes, as well as the effects of the opposing steroid DEX on this development. Results: The continuous presence of DHEA (1026 M) in GM-CSF/IL-4-induced monocyte-derived DC cultures resulted in immature DC with a morphology and functional capabilities similar to those of typical immature DC (T cell stimulation, IL-12/IL-10 production), but with a slightly altered phenotype of increased CD80 and decreased CD43 expression (markers of maturity).
  • Triclosan Disrupts Thyroid Hormones: Mode-Of-Action, Developmental Susceptibility, and Determination of Human Relevance

    Triclosan Disrupts Thyroid Hormones: Mode-Of-Action, Developmental Susceptibility, and Determination of Human Relevance

    Triclosan Disrupts Thyroid Hormones: Mode-of-Action, Developmental Susceptibility, and Determination of Human Relevance Katie Beth Paul “A dissertation submitted to the faculty of the University of North Carolina at Chapel Hill in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Toxicology.” Chapel Hill 2011 Approved by: Kim L. R. Brouwer, Pharm.D., Ph.D. Kevin M. Crofton, Ph.D. Michael J. DeVito, Ph.D. Philip C. Smith, Ph.D James A. Swenberg, D.V.M., Ph.D. ©2011 Katie Beth Paul ALL RIGHTS RESERVED ii Abstract Katie Beth Paul Triclosan Disrupts Thyroid Hormones: Mode-of-Action, Developmental Susceptibility, and Determination of Human Relevance (Under the direction of Kevin M. Crofton, Ph.D.) Preliminary study demonstrated that triclosan (TCS), a bacteriostat in myriad consumer products, decreases serum thyroxine (T4) in rats. Adverse neurodevelopmental consequences result from thyroid hormone (TH) disruption; therefore determination of whether TCS disrupts THs during development, its mode-of-action (MOA), and the human relevance is critical. This research tested the hypothesis that TCS disrupts THs via activation of pregnane X and constitutive androstane receptors (PXR, CAR), mediating Phase I-II enzyme and hepatic transporter expression and protein changes, thereby increasing catabolism and elimination of THs, resulting in decreased TH concentrations. For Aim One, the hypothesized MOA was assessed using weanling female Long-Evans rats orally exposed to TCS (0-1000 mg/kg/day) for four days. Serum T4 decreased 35% at 300 mg/kg/day. Activity and expression of markers of Phase I (Cyp2b, Cyp3a1) and Phase II (Ugt1a1, Sult1c1) metabolism were moderately induced, consistent with PXR and/or CAR activation and increased hepatic catabolism.
  • University of Groningen Discovery of a Eugenol Oxidase From

    University of Groningen Discovery of a Eugenol Oxidase From

    University of Groningen Discovery of a eugenol oxidase from Rhodococcus sp strain RHA1 Jin, J.F.; Mazon, H.; van den Heuvel, R.H.H.; Janssen, D.B.; Fraaije, M.W. Published in: Febs Journal DOI: 10.1111/j.1742-4658.2007.05767.x IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Jin, J. F., Mazon, H., van den Heuvel, R. H. H., Janssen, D. B., & Fraaije, M. W. (2007). Discovery of a eugenol oxidase from Rhodococcus sp strain RHA1. Febs Journal, 274(9), 2311 - 2321. https://doi.org/10.1111/j.1742-4658.2007.05767.x Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 23-09-2021 Discovery of a eugenol oxidase from Rhodococcus sp.
  • An Open-Label Pilot Trial of Alpha-Lipoic Acid for Weight Loss in Patients with Schizophrenia Without Diabetes Joseph C

    An Open-Label Pilot Trial of Alpha-Lipoic Acid for Weight Loss in Patients with Schizophrenia Without Diabetes Joseph C

    Case Reports An Open-Label Pilot Trial of Alpha-Lipoic Acid for Weight Loss in Patients with Schizophrenia without Diabetes Joseph C. Ratliff1 , Laura B. Palmese 1, Erin L. Reutenauer 1, Cenk Tek 1 Abstract A possible mechanism of antipsychotic-induced weight gain is activation of hypothalamic monophosphate-dependent kinase (AMPK) mediated by histamine 1 receptors. Alpha-lipoic acid (ALA), a potent antioxidant, counteracts this ef- fect and may be helpful in reducing weight for patients taking antipsychotics. The objective of this open-label study was to assess the efficacy of ALA (1,200 mg) on twelve non-diabetic schizophrenia patients over ten weeks. Participants lost significant weight during the intervention (-2.2 kg±2.5 kg). ALA was well tolerated and was particularly effective for individuals taking strongly antihistaminic antipsychotics (-2.9 kg±2.6 kg vs. -0.5 kg±1.0 kg). Clinical Trial Registra- tion: NCT01355952. Key Words: Schizophrenia, Obesity, Schizoaffective Disorder, Alpha-Lipoic Acid Introduction dependent protein kinase (AMPK) in the hypothalamus Antipsychotic medications appear to induce weight (4). In the periphery, AMPK increases energy utilization; gain, which results in increased rates of obesity in schizo- AMPK activity in the hypothalamus increases appetite. phrenia (1). Schizophrenia patients have significantly short- Several highly orexigenic (stimulates appetite) antipsy- er life expectancy than the general population (2); most of chotics such as clozapine, olanzapine, and quetiapine are this excess mortality is attributed to diabetes and cardiovas- shown to activate AMPK in the hypothalamus in animal cular disease (3); weight gain is a significant contributor to studies whereas other antipsychotic medications do not (4).