Keyword Index

Volume 5 1998

15-deoxyspergualin 85 (BC) bcl-2 1156 complex stability 137 (BC) 293 cells adenoviral vectors 563 (BC) bicistronic vectors 1566 (BC) computerized tomography 896 5-azacytidine 1299 bidirectional promoter 76 connexin43 1114, 1221, 1372 5-fluorocytosine 507 biodegradable microspheres 740 cord blood 233 6-hydroxydopamine (6-OHDA) 1650 biolistics 692 corneal endothelium 1347 99mTc 798 BMP-7 1098 coronary infusion 1472 bone repair 1098 costimulation 223 AAV 50, 820 bradykinin 630 costimulatory 965 AAV helper genes 938 brain 712 (BC), 820 Cre-mediated recombination 1047 AAV vector production 938 brain tumors 1122 Cre/loxP 684 adeno-associated virus 277 (BC), 1434, breast tumor 240 cyclophosphamide 189 1604, 1642 bronchoscopy 166 cystic fibrosis 91, 131 (BC), 181, 218, 309, adeno-associated virus (AAV) 166 bystander effect 105, 113, 605, 1114, 1221, 345, 583, 1488 adenosine deaminase 320 1372, 1705 cytidine deaminase 1545 adenoviral gene transfer 85 cytochrome P450 1070 adenoviral vectors 309, 869, 1251 C2C12 1014 cytokine gene 1462 adenovirus 8, 19, 131 (BC), 174, 339, 345, CAG 240 cytokine gene transfer 481 352, 473, 507, 605, 621, 630, 740, 747, cancer 728 (R), 1105, 1400, 1462 cytokine receptors 253 778, 938, 975, 995, 1023, 1038, 1130, cancer gene therapy 189, 451, 1171 cytokines 253, 869, 1400 1156, 1213, 1259, 1314, 1363, 1400, 1552, cancer vaccine 247, 1677 cytosine arabinoside 1545 1612 canine 40, 865 cytosine deaminase 1130, 1571 (BC) adenovirus (Ad) 166 capillary permeability 630 cytotoxic T lymphocytes 189, 459 adenovirus infection 1340 capsules 828 adenovirus knob 798 carboxy-terminal deletions 1631 decorin 1187 adenovirus type 41 645 cationic agent 1180 delivery 848 adenovirus type 5 645 cationic lipids 137 (BC), 855 (BC), 995, dendritic cells 264, 700, 718 (BC) adenovirus vectors 465, 497, 965, 1148 1272 diabetes 8 (BC) cationic liposomes 181, 240, 301, 380, 583, DMI-2 1244 adenovirus-mediated gene transfer 361 614, 930, 955, 1531, 1538 DMRIE 1272 adjuvant 1447, 1677 cationic polymers 712 (BC), 1291 (BC) DNA 865, 1235 adoptive immunotherapy 1508 cationic vector 1508 DNA compaction 855 (BC) AIDS 99 CB1954 105, 1061 DNA complexes 1410 + alkyltransferase 835, 842 CD34 blood cells 465 DNA-binding domain 1204 + allogeneic tumour vaccination 1447 CD34 cells 233 dopamine 820 + anemia 1014 CD4 cells 655 drug resistance 1545 angiogenesis 747, 1105 CD40 ligand 431 DTH reactivity 481 animal 1622 CD80 965, 1355 Duchenne muscular dystrophy 59, 369, anti-idiotypic response 828 CEA 865 1340 antibody 459, 995 CEA promoter 1363 dystrophin 19, 59 antibody delivery 828 cell adhesion 913, 1322 dystrophin minigene 1340 antigen 975 cell cycle regulatory gene 761 dystrophin-associated proteins 19 antisense 1455 cell invasion 1105 antisense RNA 1462 cellular 865 E1A 1538 antisense therapy 388 cellulose sulphate matrix 828 EBNA1 1389 APC 431 central nervous system 50, 1137 EBV 1171 aphidicolin 1481 CFU-S 842 EBV LMP1 905 apoptosis 331, 563 (BC), 605, 728 (R) chemokine receptor 984 EBV vector 1031 arteries 1023 chloroquine 409 (BC) ecotropic retrovirus 621 artificial epidermis 1322 cholecystokinin 848 efficiency 621 aspartylglucosaminidase 1314 cholesterol 137 (BC) EGF receptor 521 aspartylglucosaminuria 1314 CIK cells 31 elafin 352 attenuated herpesviruses 160 CNS 740 elastase 1023 attitudes 218 cochlea, hearing disorders 277 (BC) elastase-specific inhibitor 352 collagen-induced arthritis 1584 electroporation 700, 1347 ␤-galactosidase 277 (BC), 301, 1283 (BC) colon carcinoma 507 electroretinogram 1088 ␤-glucuronidase 1642 colorectal cancer 869, 1054 encapsulation 1014, 1070 B16-F10 melanoma 1447 colorectal tumour 223 endoscopy 166 B7.1 965, 1447 complement inhibitors 531 endosomolysis 409 (BC) baculovirus vectors 531 complement system 531 endothelial cell 614 basement membrane 1322 complement-dependent selection 282 (BC) endothelial cell-specific transcription 1656 Keyword index 1718 endothelium 272 (BC), 747 hematopoiesis 692, 755 internal ribosome entry site 65 episomal maintenance 1389 hematopoietic cells 1545, 1575 (BC) intestine 645 Epstein–Barr virus 1389 hematopoietic progenitor cells 718 (BC) intracerebral 121 equine infectious anemia virus 1481 hemophilia B 40, 394 intracerebral gene transfer 1650 erythropoietin 665, 1014 hepatocellular carcinoma 1114 intracoronary gene delivery 301 etoposide 189 hepatocytes 531, 888, 1259 intrakine 984 ex vivo approach 19 hepatoma 880 IRES 635, 1003 (BC), 1441 (BC), 1566 (BC) Exosurf 1333 hepatoma cells 1204 extracellular matrix 1322 HER-2/neu 1538 K562 835 extrusion 1272 herpes simplex thymidine kinase (HTK) eye 1038, 1561 (BC) 1698 lacZ 1347 herpes simplex virus 1517, 1593 lacZ gene 789 FACS 556 (BC) herpes simplex virus thymidine kinase laminin-5 1322 factor IX 40, 394 1372, 1705 late effects 196 Fas ligand 1622 herpes simplex viruses 121 latent membrane protein 1 1171 Fas-mediated apoptosis 1047 herpes vector 718 (BC), 1137 lentiviral vector 1481 Fas/Apo-1 563 (BC) high-density lipoproteins 1434 lentivirus vector 635 Fas/FasL 331 HIV 1665 leukemia/lymphoma 1355 FasL 563 (BC) HIV Env 655 ligament 1165, 1455 FDG 880 HIV-1 65, 233, 946, 984 linamarase/linamarin 1499 flow cytometry 209, 700 HIV-inducible vector 1665 lipofection 380, 542, 708 (BC) fluorescence microscopy 556 (BC) HMG-12 240 lipoplex 542 formulation 1235, 1272 homologous recombination 149 (R) liposome 380, 388, 1165, 1306, 1455, 1488 fusigenic peptides 955 HPV 1462 lipospermine 855 (BC) fusion 770 HSV 491, 594, 1420 liver 431, 552 (BC), 1180, 1259 fusion protein 521 HSV-1 440, 809, 1566 (BC) liver gene therapy 531 HSV-1 thymidine kinase 419 (BC) local therapy 1070 GAL4 521 HSV-thymidine kinase 614, 880 long-term expression 85 ganciclovir 905, 1054, 1363, 1372, 1705 HSVtk 1114, 1122, 1363 long-term gene expression 1031 ganciclovir elaidic ester 419 (BC) human alpha-1-antitrypsin 85 lung 1333 gap junction 1372, 1705 human CD34+ 835 lung cancer 778 gastrointestinal-specific transcription 1656 human monocytes 1508 lung cancer cells 361 gene delivery 645, 955, 1137, 1251, 1272, humoral 865 lung gene therapy 181 1333, 1410, 1434, 1566 (BC) HVJ liposome 1031, 1472 lymphocytes 209, 984 gene expression 253 hybrid cells 1447 lymphoma 403 gene regulation 320, 1604 hybridoma 828 lymphoproliferative diseases 1171 gene targeting 149 (R) lysosomal storage 1314 gene therapeutics 537 ICAM-1 131 (BC) lysosomal storage disease 1642 gene therapy 50, 59, 65, 76, 91, 99, 105, IFN␤ 253 lysosomes 473 131 (BC), 149 (R), 166, 218, 223, 233, 272 IFN-␥ 1508 (BC), 282 (BC), 293, 309, 320, 331, 345, ifosfamide 1070 macrophage depletion 431 352, 419 (BC), 431, 491, 507, 521, 552 IL-12 223 malignant gliomas 160, 293, 1187 (BC), 556 (BC), 583, 605, 614, 621, 630, IL-12 secretion 481 mammary adenocarcinoma 388 665, 692, 708 (BC), 728 (R), 740, 747, IL-2R␣ 635 MBP promoter 50 761, 778, 880, 888, 905, 923, 930, 946, IL2 975 MDR1 671 965, 984, 1003 (BC), 1023, 1054, 1088, imaging 798 mdx 59 1098, 1114, 1122, 1130, 1148 (BC), 1156, immune privilege 563 (BC), 1038 mdx diaphragm 369 1165, 1180, 1187, 1227, 1283 (BC), 1291 immune response 1038, 1561 (BC) mdx mouse 19 (BC), 1299, 1306, 1314, 1347, 1379, 1389, immune system 1187 medulloblastoma 113 1400, 1441 (BC), 1455, 1462, 1488, 1499, immune therapy 1187 melanoma 223, 975, 1130 1531, 1538, 1552, 1561 (BC), 1584, 1612, immunity 309, 789, 809 methotrexate 1379 1642, 1665, 1677, 1685, 1705 immunogene therapy 1195, 1355 methylation 1299 gene transfer 40, 113, 174, 272 (BC), 380, immunosuppression 85, 369, 497, 1612 mGM-CSF 76, 770 403, 465, 514, 542, 575, 655, 671, 700, immunotherapy 869, 1079, 1400 microinjection 409 (BC) 708 (BC), 712 (BC), 809, 855 (BC), 896, importin subunits 1204 micronucleus 842 930, 995, 1079, 1221, 1244, 1259, 1425, in situ PCR 755 migration 1698 1472, 1545, 1593, 1604, 1622 in vivo 1265 MMTV-neu 388 genetic immunization 789 in vivo expression 1545 MnSOD 196 GFAP promoter 440 in vivo gene transduction 459 monkey 820 GFP 684 inborn errors of metabolism 677 monocytes 99 GFP fusion proteins 1420 inducible apoptosis 923 mouse melanoma 247 glial fibrillary acidic protein 1650 induction of apoptosis 1631 mouse models 160, 1314 glioma 121, 809, 1698 INF-␥ 240 mucopolysaccharidosis 1642 glioma therapy 440 INF7 409 (BC) multidrug resistance 403 gliomas 1221 inflammation 1283 (BC) multigene vectors 1517 glucose 8 inflammatory cells 121 multiple sclerosis model 253 GM-CSF 223, 1355 inhibitory cytokine 1265 murine 1265 gp75 975 insulin 888 muscle 40, 272 (BC), 514, 677, 1283 (BC) granulocyte–macrophage colony- integrin 361, 1259, 1488 muscle function 369 stimulating factor 1130 interleukin-1 778 Mycobacterium tuberculosis 247 green fluorescent protein (GFP), 50, 166, interleukin-2 1003 (BC) myelofibrosis 497 700, 1148 (BC) interleukin-3 778 myelosuppression 497 growth hormone 537 interleukin-4 121 myoblast transplantation 1340 interleukin-7 31 myoblasts 1014, 1306 hammerhead ribozyme 1227 interleukin-10, 121 myocardinal infarction 301 heart diseases 630 internal promoter 1299 myocardium 1472 Keyword index 1719 myogenic cells 1306 prodrug 507 spinal cord 1612 myopathy 473 prodrug therapy 1070 sputum 91 promoter 514, 789, 1650 stem cells 149 (R), 692, 913, 1265 protein trafficking 1420 storage disease 473 N13-ras transformation 1227 proteinase inhibitor 352 striatum 594 naked DNA 1531 pseudofection 1410 structure–function relationship 1685 nebulisation 583 Pseudomonas aeruginosa 345 sucrase isomaltase promoter 1656 neo 1441 (BC) Pseudomonas exotoxin A 521 suicide gene 451, 905, 923, 1130 neor 684 pseudotype 209 surfactant 1333 neurons 1604 susceptibility 361 neurovirulent 594 systemic protein delivery 537 neutralization 995 RAD genes 149 (R) neutralizing antibodies 189 radiation 293 T cells 31, 309 neutrophils 345 radiation fibrosis 196 T-lymphocytes 320, 1612 NF␬B 174 rat 451, 848 tat transdominant mutants 946 NF-␬B activation 905 rat brain 1137 temozolomide 842 nitroreductase 105, 1061 rat glioblastoma 1499 tetracycline 1213 NK cells 31 rd mouse 1156 tetracycline-controlled transactivator 76 nNOS 59 receptor 848 TGF-␣ 521 non-viral gene delivery 521 receptor-mediated gene transfer 31, 1685 therapeutic vaccination 778 nonhomologous recombination 149 (R) recombinant adeno-associated virus 665 thermal nociception 1612 nonhuman primates 665 recombinant adenovirus 293, 431, 770, 896, thrombopoietin 497 nonviral 712 (BC), 1291 (BC) 1047, 1105, 1122 thymidine kinase 113, 905, 1003 (BC), nonviral DNA transfer 1204 recombinant leptin 8 1054, 1299 nuclear localization signals 1204 regeneration 1283 (BC) tissue engineering 1098 nuclease inhibition 1244 regulatable expression 888 tissue inhibitor of metalloproteinase 1552 nude mice 1372 regulatable transcription 1213 tissue-specific promoters 1656 remodelling 761 TNF antagonists 253 6 replication 65 TNF-␣ 240, 1677 O -alkylating agents 835 reporter gene 594 O6-benzylguanine 835, 842 toxicity 451, 1122, 1363 restenosis 1023 trafficking 1306 obesity 8 retina 1088 l transactivation 1631 oligo- -lysine 1488 retinal degeneration 1088, 1156 oligomerisation 1631 transcription repressor 946 retrograde transport 594 oligonucleotide 1472 transcriptional control 1575 (BC) retroviral 1265 oriP 1389 transcriptional targeting 1656 retroviral interleukin-7 gene transfer 264 orthopedics 1098 transcripts 339 retroviral vectors 99, 282 (BC), 394, 655, ovarian cancer 1061, 1538 transduction efficiency 339 671, 1003 (BC), 1098, 1195, 1227, 1251, transfection 409 (BC), 1333, 1531 1499, 1571 (BC), 1575 (BC), 1698 transfection efficiency 700 retrovirus 403, 552 (BC), 835, 1054, 1180, transferrin 955, 1425 p53 339, 361, 605, 747, 1631 ␤ packaging cell line 99 1299, 1379, 1441 (BC) transforming growth factor 1187, 1265 packaging cells 1251 retrovirus-mediated gene transfer 556 transgene expression 575 pancreas 848 (BC), 755 transgenic mice 320, 388 pancreatic cancer 1061, 1070 reverse cholesterol transport 1434 transgenics 1213 papovavirus 575 RGD 1488 transplantation 1079 parkinson 820 rhDNase 91 tri-iodothyronine 552 (BC) Parkinson’s disease 1650 rheumatoid arthritis 331 tTA-responsive promoter 76 rHGFP 556 (BC) tumor 789, 1622 particle charge 1235 ␣ particle size 1425 rhodopsin promoter 1156 tumor necrosis factor- 293 parvovirus 40 ribonuclease 65 tumor vaccine 1355 PDGF 1165 ribozyme 233, 1665 tumour necrosis factor p75 receptor 1584 PEPCK 888 rIL-12 1677 tyrosine-hydroxylase 820, 1650 peritoneal carcinomatosis 1054 RL1 variants 440 PET 880 RNA decoys 1665 urokinase 1105 phenotype 761 RU486 491 phenylketonuria 677 photoreceptor 1561 (BC) vaccine 865, 975 plasmid 1283 (BC) salivary glands 537 vascularization 896 plasmid DNA 272 (BC), 1291 (BC) self-amplifying vector 415 (BC) VDEPT 1061 plasmid vector 415 (BC) Semliki Forest virus 415 (BC) vein graft 1552 PLGA 740 Sendai virus 1165, 1455 venous arterial graft failure 761 pneumocytes 1291 (BC) serotonin 630 viral interleukin-10 (vIL-10) 1079 poly-l-lysine 409 (BC), 1235, 1685 serpin enzyme complex receptor 1685 viral toxicity 369 polybrene 708 (BC) serum 137 (BC) viral vectors 1148 (BC), 1347 polycations 1410 serum inhibition 1306 vitrectomy 1088 polyethylene glycol 995 serum sensitivity 380 von Willebrand factor promoter 1656 polyethylenimine 712 (BC), 1425 single chain chimeric receptor 1195 VP22 1420 polymers 740, 930 single gene retroviral vectors 684 VSV-G protein 635 polyomavirus 1410 single-chain antibody 635, 1171 positive feedback regulatory system 76 single-chain Fv 770 wound healing 1165, 1347, 1455 positive selection 1571 (BC) SIV retroviral vector 209 primary liver cancer 896 size 1235 XSCID 671 primary neurons 1593 skeletal muscle 59, 542, 1434 primate brain 1137 skin grafting 394 primitive hematopoietic cells 556 (BC) smooth muscle cell 1552 yeast p53 functional assay 339 Keyword index 1720