Data Set 1. Biological analysis of the genes found to be significant in the endotoxin study. Pages 2 – 105: Q values, gene names and annotation on the genes significant at FDR = 0.1%. Pages 106 – 127: Global functional analysis of the down-regulated genes. Pages 128 – 169: Global functional analysis of the up-regulated genes. Probe Set q-value Direction Gene Annotation

117_at 9.60E-05 up HSPA6 heat shock 70kDa protein 6 (HSP70B') 1405_i_at 2.00E-06 down CCL5 chemokine (C-C motif) ligand 5

PRP8 pre-mRNA processing factor 8 200000_s_at 2.50E-05 down PRPF8 homolog (yeast) PRP8 pre-mRNA processing factor 8 200000_s_at 0.000712 down PRPF8 homolog (yeast) 200001_at 0.000658 down CAPNS1 calpain, small subunit 1 200002_at 2.00E-06 down RPL35 ribosomal protein L35 200002_at 2.00E-06 down RPL35 ribosomal protein L35 200003_s_at 1.10E-05 down RPL28 ribosomal protein L28 200003_s_at 1.10E-05 down RPL28 ribosomal protein L28 eukaryotic translation initiation factor 3, 200005_at 2.00E-06 down EIF3S7 subunit 7 zeta, 66/67kDa eukaryotic translation initiation factor 3, 200005_at 2.00E-06 down EIF3S7 subunit 7 zeta, 66/67kDa Parkinson disease (autosomal 200006_at 4.70E-05 down PARK7 recessive, early onset) 7 Parkinson disease (autosomal 200006_at 8.70E-05 down PARK7 recessive, early onset) 7 200008_s_at 5.40E-05 up GDI2 GDP dissociation inhibitor 2 200008_s_at 0.000361 up GDI2 GDP dissociation inhibitor 2 200009_at 0.000171 down GDI2 GDP dissociation inhibitor 2 200010_at 2.00E-06 down RPL11 ribosomal protein L11 200010_at 2.00E-06 down RPL11 ribosomal protein L11 200012_x_at 2.00E-06 down 200012_x_at 2.00E-06 down 200013_at 2.00E-06 down MAMDC2 MAM domain containing 2 200013_at 2.00E-06 down MAMDC2 MAM domain containing 2 neural precursor cell expressed, 200015_s_at 2.80E-05 down NEDD5 developmentally down-regulated 5 neural precursor cell expressed, 200015_s_at 0.000169 down NEDD5 developmentally down-regulated 5 heterogeneous nuclear 200016_x_at 2.00E-06 down HNRPA1 ribonucleoprotein A1 heterogeneous nuclear 200016_x_at 2.00E-06 down HNRPA1 ribonucleoprotein A1 200017_at 2.00E-06 down RPS27A ribosomal protein S27a 200017_at 1.10E-05 down RPS27A ribosomal protein S27a 200018_at 2.00E-06 down RPS13 ribosomal protein S13 200018_at 2.00E-06 down RPS13 ribosomal protein S13 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal 200019_s_at 2.00E-06 down FAU protein S30 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal 200019_s_at 2.90E-05 down FAU protein S30 200020_at 9.20E-05 down TARDBP TAR DNA binding protein 200022_at 2.00E-06 down RPL18 ribosomal protein L18 200022_at 2.00E-06 down RPL18 ribosomal protein L18 eukaryotic translation initiation factor 3, 200023_s_at 2.00E-06 down EIF3S5 subunit 5 epsilon, 47kDa eukaryotic translation initiation factor 3, 200023_s_at 2.00E-06 down EIF3S5 subunit 5 epsilon, 47kDa 200024_at 2.00E-06 down RPS5 ribosomal protein S5 200024_at 2.00E-06 down RPS5 ribosomal protein S5 200025_s_at 2.00E-06 down RPL27 ribosomal protein L27 200025_s_at 2.00E-06 down RPL27 ribosomal protein L27 200026_at 2.00E-06 down RPL34 ribosomal protein L34 200026_at 2.00E-06 down RPL34 ribosomal protein L34 200027_at 2.00E-06 down NARS asparaginyl-tRNA synthetase 200027_at 4.00E-06 down NARS asparaginyl-tRNA synthetase 200028_s_at 2.00E-06 down STARD7 START domain containing 7 200028_s_at 2.00E-06 down STARD7 START domain containing 7 200029_at 2.00E-06 down RPL19 ribosomal protein L19 200029_at 2.00E-06 down RPL19 ribosomal protein L19 solute carrier family 25 (mitochondrial 200030_s_at 2.00E-06 down SLC25A3 carrier; phosphate carrier), member 3 solute carrier family 25 (mitochondrial 200030_s_at 9.60E-05 down SLC25A3 carrier; phosphate carrier), member 3 200031_s_at 2.00E-06 down RPS11 ribosomal protein S11 200031_s_at 2.00E-06 down RPS11 ribosomal protein S11 200032_s_at 2.00E-06 down RPL9 ribosomal protein L9 200032_s_at 2.00E-06 down RPL9 ribosomal protein L9 200034_s_at 2.00E-06 down RPL6 ribosomal protein L6 200034_s_at 2.00E-06 down RPL6 ribosomal protein L6 200036_s_at 2.00E-06 down RPL10A ribosomal protein L10a 200036_s_at 2.00E-06 down RPL10A ribosomal protein L10a chromobox homolog 3 (HP1 gamma 200037_s_at 0.000716 down CBX3 homolog, Drosophila) 200038_s_at 2.00E-06 down RPL17 ribosomal protein L17 200038_s_at 2.00E-06 down RPL17 ribosomal protein L17 proteasome (prosome, macropain) 200039_s_at 3.80E-05 down PSMB2 subunit, beta type, 2 200041_s_at 0.000479 down BAT1 HLA-B associated transcript 1 200042_at 8.90E-05 down HSPC117 hypothetical protein HSPC117 200042_at 0.000676 down HSPC117 hypothetical protein HSPC117 enhancer of rudimentary homolog 200043_at 1.80E-05 down ERH (Drosophila) enhancer of rudimentary homolog 200043_at 2.80E-05 down ERH (Drosophila) 200050_at 2.00E-06 down ZNF146 zinc finger protein 146 200050_at 9.00E-06 down ZNF146 zinc finger protein 146 interleukin enhancer binding factor 2, 200052_s_at 2.00E-06 down ILF2 45kDa interleukin enhancer binding factor 2, 200052_s_at 5.00E-05 down ILF2 45kDa 200054_at 0.000485 down ZNF259 zinc finger protein 259 non-POU domain containing, octamer- 200057_s_at 2.00E-06 down NONO binding non-POU domain containing, octamer- 200057_s_at 2.00E-06 down NONO binding 200058_s_at 9.50E-05 down U5-200KD U5 snRNP-specific protein, 200-KD 200058_s_at 0.00039 down U5-200KD U5 snRNP-specific protein, 200-KD RNA binding protein S1, serine-rich 200060_s_at 2.00E-06 down RNPS1 domain RNA binding protein S1, serine-rich 200060_s_at 7.00E-06 down RNPS1 domain 200061_s_at 2.00E-06 down RPS24 ribosomal protein S24 200061_s_at 2.00E-06 down RPS24 ribosomal protein S24 200062_s_at 2.00E-06 down RPL30 ribosomal protein L30 200062_s_at 2.00E-06 down RPL30 ribosomal protein L30 nucleophosmin (nucleolar 200063_s_at 2.00E-06 down NPM1 phosphoprotein B23, numatrin) nucleophosmin (nucleolar 200063_s_at 2.00E-06 down NPM1 phosphoprotein B23, numatrin) 200067_x_at 9.80E-05 up SNX3 sorting nexin 3 200068_s_at 3.90E-05 down CANX calnexin 200068_s_at 0.000313 down CANX calnexin squamous cell carcinoma antigen 200069_at 4.00E-06 down SART3 recognised by T cells 3 squamous cell carcinoma antigen 200069_at 0.000177 down SART3 recognised by T cells 3 heterogeneous nuclear ribonucleoprotein D (AU-rich element 200073_s_at 2.00E-06 down HNRPD RNA binding protein 1, 37kDa) 200074_s_at 2.00E-06 down RPL14 ribosomal protein L14 200074_s_at 2.00E-06 down RPL14 ribosomal protein L14 200081_s_at 2.00E-06 down 200081_s_at 2.00E-06 down 200082_s_at 2.00E-06 down RPS7 ribosomal protein S7 200082_s_at 2.00E-06 down RPS7 ribosomal protein S7 200084_at 0.000965 down SMAP small acidic protein cytochrome c oxidase subunit IV 200086_s_at 7.70E-05 down COX4I1 isoform 1 cytochrome c oxidase subunit IV 200086_s_at 0.000548 down COX4I1 isoform 1 200088_x_at 2.00E-06 down RPL12 ribosomal protein L12 200088_x_at 2.00E-06 down RPL12 ribosomal protein L12 200089_s_at 2.00E-06 down RPL4 ribosomal protein L4 200089_s_at 2.00E-06 down RPL4 ribosomal protein L4 200090_at 0.000112 down FNTA farnesyltransferase, CAAX box, alpha 200091_s_at 2.00E-06 down RPS25 ribosomal protein S25 200091_s_at 0.000128 down RPS25 ribosomal protein S25 200092_s_at 2.00E-06 down RPL37 ribosomal protein L37 200092_s_at 3.80E-05 down RPL37 ribosomal protein L37 histidine triad nucleotide binding 200093_s_at 4.00E-06 down HINT1 protein 1 histidine triad nucleotide binding 200093_s_at 3.80E-05 down HINT1 protein 1 eukaryotic translation elongation factor 200094_s_at 2.00E-06 down EEF2 2 eukaryotic translation elongation factor *probe sets 200094_s_at 2.00E-06 down EEF2 2 200000_s_at - 200095_x_at 2.00E-06 down RPS10 ribosomal protein S10 200099_s_at are present on 200095_x_at 2.00E-06 down RPS10 ribosomal protein S10 both Human U133-A chip and 200098_s_at 2.00E-06 down ANAPC5 anaphase promoting complex subunit 5 U133-B chip. Therefore these 200098_s_at 2.00E-06 down ANAPC5 anaphase promoting complex subunit 5 probes are 200099_s_at 2.00E-06 down RPS3A ribosomal protein S3A measured twice 200099_s_at 2.00E-06 down RPS3A ribosomal protein S3A for each sample. eukaryotic translation initiation factor 3, 200595_s_at 4.70E-05 down EIF3S10 subunit 10 theta, 150/170kDa eukaryotic translation initiation factor 3, 200596_s_at 4.00E-06 down EIF3S10 subunit 10 theta, 150/170kDa 200599_s_at 0.00012 down TRA1 tumor rejection antigen (gp96) 1 200610_s_at 2.00E-06 down NCL nucleolin 200624_s_at 1.80E-05 down MATR3 matrin 3 200626_s_at 5.50E-05 down MATR3 matrin 3 200629_at 0.000553 up WARS tryptophanyl-tRNA synthetase SET translocation (myeloid leukemia- 200630_x_at 9.60E-05 down SET associated) SET translocation (myeloid leukemia- 200631_s_at 2.00E-06 down SET associated) 200634_at 2.80E-05 up PFN1 profilin 1

superoxide dismutase 1, soluble 200642_at 2.00E-06 down SOD1 (amyotrophic lateral sclerosis 1 (adult)) 200644_at 0.000459 down MLP MARCKS-like protein 200646_s_at 4.90E-05 up NUCB1 nucleobindin 1 eukaryotic translation initiation factor 3, 200647_x_at 2.00E-06 down EIF3S8 subunit 8, 110kDa 200649_at 1.90E-05 up NUCB1 nucleobindin 1 200650_s_at 4.20E-05 up LDHA lactate dehydrogenase A guanine nucleotide binding protein (G 200651_at 2.00E-06 down GNB2L1 protein), beta polypeptide 2-like 1 calmodulin 1 (phosphorylase kinase, 200655_s_at 0.000143 down CALM1 delta) solute carrier family 25 (mitochondrial carrier; adenine nucleotide 200657_at 2.00E-06 down SLC25A5 translocator), member 5 translocase of outer mitochondrial 200662_s_at 2.00E-06 down TOMM20 membrane 20 homolog (yeast) lysosomal-associated protein 200673_at 2.00E-06 down LAPTM4A transmembrane 4 alpha 200674_s_at 2.00E-06 down RPL32 ribosomal protein L32 CD81 antigen (target of antiproliferative 200675_at 2.00E-06 down CD81 antibody 1) 200680_x_at 0.000488 down HMGB1 high-mobility group box 1 200681_at 8.00E-06 down GLO1 glyoxalase I 200685_at 8.00E-06 down SFRS11 splicing factor, arginine/serine-rich 11 200686_s_at 0.000822 down SFRS11 splicing factor, arginine/serine-rich 11 eukaryotic translation elongation factor 200689_x_at 2.00E-06 down EEF1G 1 gamma heat shock 70kDa protein 9B (mortalin- 200691_s_at 3.50E-05 down HSPA9B 2) heat shock 70kDa protein 9B (mortalin- 200692_s_at 0.000117 down HSPA9B 2)

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 200693_at 2.00E-06 down YWHAQ theta polypeptide DEAD (Asp-Glu-Ala-Asp) box 200694_s_at 2.00E-06 down DDX24 polypeptide 24 200696_s_at 1.10E-05 up GSN gelsolin (amyloidosis, Finnish type) 200701_at 0.000641 down NPC2 Niemann-Pick disease, type C2

200703_at 9.70E-05 down DNCL1 dynein, cytoplasmic, light polypeptide 1 eukaryotic translation elongation factor 200705_s_at 2.00E-06 down EEF1B2 1 beta 2

200706_s_at 2.90E-05 up LITAF lipopolysaccharide-induced TNF factor 200715_x_at 2.00E-06 down RPL13A ribosomal protein L13a 200716_x_at 2.00E-06 down RPL13A ribosomal protein L13a 200717_x_at 2.00E-06 down RPL7 ribosomal protein L7 membrane component, chromosome 200723_s_at 5.20E-05 down M11S1 11, surface marker 1 200725_x_at 2.00E-06 down RPL10 ribosomal protein L10 protein phosphatase 1, catalytic 200726_at 2.00E-06 down PPP1CC subunit, gamma isoform protein tyrosine phosphatase type IVA, 200731_s_at 0.000893 up PTP4A1 member 1 200734_s_at 2.00E-06 up ARF3 ADP-ribosylation factor 3 nascent-polypeptide-associated 200735_x_at 2.00E-06 down NACA complex alpha polypeptide 200736_s_at 1.70E-05 down GPX1 glutathione peroxidase 1 SMT3 suppressor of mif two 3 homolog 200739_s_at 2.50E-05 down SMT3H1 3 (yeast) SMT3 suppressor of mif two 3 homolog 200740_s_at 0.000778 down SMT3H1 3 (yeast) ribosomal protein S27 200741_s_at 2.00E-06 down RPS27 (metallopanstimulin 1) ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky 200743_s_at 0.000414 down CLN2 disease) 200749_at 1.10E-05 down RAN RAN, member RAS oncogene family 200750_s_at 7.00E-06 down RAN RAN, member RAS oncogene family 200754_x_at 0.000194 down SFRS2 splicing factor, arginine/serine-rich 2 200762_at 2.00E-06 down DPYSL2 dihydropyrimidinase-like 2 200763_s_at 2.00E-06 down RPLP1 ribosomal protein, large, P1 methionine adenosyltransferase II, 200768_s_at 5.40E-05 down MAT2A alpha prothymosin, alpha (gene sequence 200772_x_at 2.00E-06 down PTMA 28) prothymosin, alpha (gene sequence 200773_x_at 2.00E-06 down PTMA 28) activating transcription factor 4 (tax- 200779_at 0.000951 down ATF4 responsive enhancer element B67) 200781_s_at 2.00E-06 down RPS15A ribosomal protein S15a phosphoprotein enriched in astrocytes 200788_s_at 9.90E-05 down PEA15 15 200799_at 2.00E-06 up HSPA1A heat shock 70kDa protein 1A 200800_s_at 2.00E-06 up HSPA1A heat shock 70kDa protein 1A 200802_at 5.50E-05 down SARS seryl-tRNA synthetase 200809_x_at 2.00E-06 down RPL12 ribosomal protein L12 200810_s_at 1.70E-05 down CIRBP cold inducible RNA binding protein 200811_at 3.20E-05 down CIRBP cold inducible RNA binding protein chaperonin containing TCP1, subunit 7 200812_at 2.80E-05 down CCT7 (eta) 200817_x_at 2.00E-06 down RPS10 ribosomal protein S10 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring 200818_at 2.00E-06 down ATP5O protein) 200819_s_at 2.00E-06 down RPS15 ribosomal protein S15 proteasome (prosome, macropain) 26S 200820_at 0.000229 down PSMD8 subunit, non-ATPase, 8 200823_x_at 2.00E-06 down RPL29 ribosomal protein L29 200824_at 4.00E-05 down GSTP1 glutathione S-transferase pi small nuclear ribonucleoprotein D2 200826_at 2.00E-06 down SNRPD2 polypeptide 16.5kDa procollagen-lysine, 2-oxoglutarate 5- dioxygenase (lysine hydroxylase, 200827_at 0.000753 up PLOD Ehlers-Danlos syndrome type VI) proteasome (prosome, macropain) 26S 200830_at 0.000686 down PSMD2 subunit, non-ATPase, 2 200834_s_at 2.00E-06 down RPS21 ribosomal protein S21 200838_at 1.10E-05 up CTSB cathepsin B 200839_s_at 8.90E-05 down CTSB cathepsin B 200843_s_at 4.00E-05 down EPRS glutamyl-prolyl-tRNA synthetase 200847_s_at 1.80E-05 down MGC8721 hypothetical protein MGC8721 S-adenosylhomocysteine hydrolase- 200848_at 0.000304 up AHCYL1 like 1 S-adenosylhomocysteine hydrolase- 200849_s_at 5.70E-05 down AHCYL1 like 1 S-adenosylhomocysteine hydrolase- 200850_s_at 8.00E-05 down AHCYL1 like 1 200853_at 0.000346 down H2AFZ H2A histone family, member Z 200858_s_at 2.00E-06 down RPS8 ribosomal protein S8 200869_at 2.00E-06 down RPL18A ribosomal protein L18a serine/threonine kinase receptor 200870_at 0.000494 down UNRIP associated protein S100 calcium binding protein A10 (annexin II ligand, calpactin I, light 200872_at 2.00E-06 down S100A10 polypeptide (p11)) chaperonin containing TCP1, subunit 8 200873_s_at 2.00E-05 down CCT8 (theta) nucleolar protein 5A (56kDa with 200875_s_at 2.00E-06 down NOL5A KKE/D repeat) chaperonin containing TCP1, subunit 4 200877_at 6.90E-05 down CCT4 (delta) 200885_at 8.00E-05 down ARHC ras homolog gene family, member C 200888_s_at 2.00E-06 down RPL23 ribosomal protein L23 mannose-6-phosphate receptor (cation 200901_s_at 2.00E-06 down M6PR dependent) 200909_s_at 2.00E-06 down RPLP2 ribosomal protein, large P2 chaperonin containing TCP1, subunit 3 200910_at 0.000575 down CCT3 (gamma) 200915_x_at 0.000152 down KTN1 kinectin 1 (kinesin receptor) 200916_at 2.00E-06 down TAGLN2 transgelin 2 200919_at 8.20E-05 up PHC2 polyhomeotic-like 2 (Drosophila) 200926_at 2.00E-06 down RPS23 ribosomal protein S23 200933_x_at 2.00E-06 down RPS4X ribosomal protein S4, X-linked 200934_at 1.70E-05 down DEK DEK oncogene (DNA binding) 200936_at 2.00E-06 down RPL8 ribosomal protein L8 200937_s_at 2.00E-06 down RPL5 ribosomal protein L5 arginine-glutamic acid dipeptide (RE) 200939_s_at 0.000368 up RERE repeats high-mobility group nucleosome 200943_at 2.00E-06 down HMGN1 binding domain 1 high-mobility group nucleosome 200944_s_at 2.00E-06 down HMGN1 binding domain 1 200945_s_at 0.000557 down SEC31L1 SEC31-like 1 (S. cerevisiae) 200946_x_at 0.000989 down GLUD1 glutamate dehydrogenase 1 200947_s_at 9.00E-06 down GLUD1 glutamate dehydrogenase 1 200949_x_at 2.00E-06 down RPS20 ribosomal protein S20 200953_s_at 2.00E-06 down CCND2 cyclin D2 inner membrane protein, mitochondrial 200955_at 1.10E-05 down IMMT (mitofilin) 200958_s_at 3.10E-05 up SDCBP syndecan binding protein (syntenin) 200963_x_at 2.00E-06 down RPL31 ribosomal protein L31 200965_s_at 1.10E-05 down ABLIM1 actin binding LIM protein 1 transmembrane 4 superfamily member 200972_at 2.10E-05 down TM4SF8 8

palmitoyl-protein thioesterase 1 (ceroid- 200975_at 0.000224 down PPT1 lipofuscinosis, neuronal 1, infantile) malate dehydrogenase 1, NAD 200978_at 3.00E-05 down MDH1 (soluble) 200982_s_at 0.000117 down ANXA6 annexin A6 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 200983_x_at 2.00E-06 up CD59 16.3A5, EJ16, EJ30, EL32 and G344) CD59 antigen p18-20 (antigen identified by monoclonal antibodies 200984_s_at 2.00E-06 up CD59 16.3A5, EJ16, EJ30, EL32 and G344) CD59 antigen p18-20 (antigen identified by monoclonal antibodies 200985_s_at 2.00E-06 up CD59 16.3A5, EJ16, EJ30, EL32 and G344) serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), 200986_at 3.90E-05 up SERPING1 member 1, (angioedema, hereditary) hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix 200989_at 0.000119 up HIF1A transcription factor) 200990_at 2.00E-04 down TRIM28 tripartite motif-containing 28 200992_at 0.000794 down IPO7 importin 7 200994_at 1.10E-05 down IPO7 importin 7 200998_s_at 2.00E-06 up CKAP4 cytoskeleton-associated protein 4 200999_s_at 2.00E-06 up CKAP4 cytoskeleton-associated protein 4 ubiquitin-conjugating enzyme E2 201001_s_at 0.00053 down UBE2V1 variant 1 ubiquitin-conjugating enzyme E2 201002_s_at 0.000199 down UBE2V1 variant 1 201003_x_at 0.000197 down signal sequence receptor, delta 201004_at 1.00E-05 down SSR4 (translocon-associated protein delta) 201012_at 5.70E-05 up ANXA1 annexin A1 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole 201013_s_at 3.00E-05 down PAICS succinocarboxamide synthetase eukaryotic translation initiation factor 201017_at 1.10E-05 down EIF1A 1A, X-linked 201021_s_at 2.80E-05 down DSTN destrin (actin depolymerizing factor) 201022_s_at 1.30E-05 down DSTN destrin (actin depolymerizing factor) 201029_s_at 4.00E-06 down CD99 CD99 antigen 201030_x_at 2.00E-06 down LDHB lactate dehydrogenase B heterogeneous nuclear 201031_s_at 4.90E-05 down HNRPH1 ribonucleoprotein H1 (H) 201032_at 1.10E-05 down BLCAP bladder cancer associated protein 201033_x_at 2.00E-06 down RPLP0 ribosomal protein, large, P0 L-3-hydroxyacyl-Coenzyme A 201034_at 0.000179 down HADHSC dehydrogenase, short chain L-3-hydroxyacyl-Coenzyme A 201036_s_at 0.000261 down HADHSC dehydrogenase, short chain 201049_s_at 2.00E-06 down RPS18 ribosomal protein S18 201050_at 3.30E-05 down PLD3 phospholipase D3 heterogeneous nuclear 201054_at 0.000106 down HNRPA0 ribonucleoprotein A0 201060_x_at 2.00E-06 up STOM stomatin 201061_s_at 2.00E-06 up STOM stomatin 201062_at 8.10E-05 up STOM stomatin poly(A) binding protein, cytoplasmic 4 201064_s_at 2.00E-06 down PABPC4 (inducible form) 201065_s_at 0.000515 up proteasome (prosome, macropain) 26S 201068_s_at 1.30E-05 down PSMC2 subunit, ATPase, 2 NHP2 non-histone chromosome 201077_s_at 2.00E-06 down NHP2L1 protein 2-like 1 (S. cerevisiae) phosphatidylinositol-4-phosphate 5- 201080_at 1.30E-05 down PIP5K2B kinase, type II, beta 201090_x_at 0.000684 down K-ALPHA-1 tubulin, alpha, ubiquitous 201092_at 2.00E-06 down RBBP7 retinoblastoma binding protein 7 succinate dehydrogenase complex, 201093_x_at 4.80E-05 down SDHA subunit A, flavoprotein (Fp) 201094_at 2.00E-06 down RPS29 ribosomal protein S29 ubiquitin specific protease 9, X-linked 201100_s_at 0.00031 down USP9X (fat facets-like, Drosophila) 201102_s_at 0.000122 down PFKL phosphofructokinase, liver glutathione peroxidase 4 (phospholipid 201106_at 5.00E-06 down GPX4 hydroperoxidase) CSE1 chromosome segregation 1-like 201111_at 2.00E-06 down CSE1L (yeast) Tu translation elongation factor, 201113_at 2.00E-06 down TUFM mitochondrial 201118_at 1.70E-05 up PGD phosphogluconate dehydrogenase 201125_s_at 4.90E-05 down ITGB5 integrin, beta 5 201128_s_at 9.60E-05 down ACLY ATP citrate lyase splicing factor, arginine/serine-rich 7, 201129_at 3.50E-05 down SFRS7 35kDa 201134_x_at 2.00E-06 down COX7C cytochrome c oxidase subunit VIIc major histocompatibility complex, class 201137_s_at 2.00E-06 down HLA-DPB1 II, DP beta 1 201152_s_at 0.000281 down MBNL1 muscleblind-like (Drosophila) 201154_x_at 2.00E-06 down RPL4 ribosomal protein L4 201160_s_at 7.00E-06 down CSDA cold shock domain protein A insulin-like growth factor binding 201163_s_at 7.00E-06 down IGFBP7 protein 7 201165_s_at 0.000878 down PUM1 pumilio homolog 1 (Drosophila) basic helix-loop-helix domain 201170_s_at 0.000198 down BHLHB2 containing, class B, 2 thioredoxin-related transmembrane 201175_at 8.00E-06 down TMX2 protein 2 201177_s_at 1.70E-05 down UBA2 SUMO-1 activating enzyme subunit 2 201178_at 0.000443 down FBXO7 F-box protein 7 201194_at 1.00E-05 down SEPW1 selenoprotein W, 1 201202_at 2.00E-06 down PCNA proliferating cell nuclear antigen 201209_at 1.10E-05 down HDAC1 histone deacetylase 1 protein phosphatase 1, regulatory 201214_s_at 2.80E-05 down PPP1R7 subunit 7 201216_at 8.00E-06 down C12ORF8 chromosome 12 open reading frame 8 201217_x_at 2.00E-06 down RPL3 ribosomal protein L3 small nuclear ribonucleoprotein 70kDa 201221_s_at 0.000295 down SNRP70 polypeptide (RNP antigen) NADH dehydrogenase (ubiquinone) 1 201226_at 0.000205 down NDUFB8 beta subcomplex, 8, 19kDa NADH dehydrogenase (ubiquinone) 1 201227_s_at 0.000144 down NDUFB8 beta subcomplex, 8, 19kDa 201230_s_at 0.000437 down ARIH2 ariadne homolog 2 (Drosophila) 201235_s_at 1.10E-05 up BTG2 BTG family, member 2 201236_s_at 9.00E-06 up BTG2 BTG family, member 2 DEAD (Asp-Glu-Ala-Asp) box 201241_at 0.000207 down DDX1 polypeptide 1 201254_x_at 2.00E-06 down RPS6 ribosomal protein S6 201257_x_at 2.00E-06 down RPS3A ribosomal protein S3A 201258_at 2.00E-06 down RPS16 ribosomal protein S16 201266_at 1.10E-05 down TXNRD1 thioredoxin reductase 1 non-metastatic cells 2, protein 201268_at 2.00E-06 down NME2 (NM23B) expressed in aldo-keto reductase family 1, member 201272_at 2.00E-06 down AKR1B1 B1 (aldose reductase) proteasome (prosome, macropain) 201274_at 0.000106 down PSMA5 subunit, alpha type, 5 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, 201275_at 0.000668 down FDPS geranyltranstransferase) heterogeneous nuclear 201277_s_at 2.40E-05 down HNRPAB ribonucleoprotein A/B 201284_s_at 0.000356 down APEH N-acylaminoacyl-peptide hydrolase peptidylprolyl isomerase A (cyclophilin 201293_x_at 2.00E-06 down PPIA A)

201294_s_at 2.10E-05 up WSB1 WD repeat and SOCS box-containing 1

201295_s_at 0.000349 up WSB1 WD repeat and SOCS box-containing 1 201301_s_at 0.000198 down ANXA4 annexin A4 DEAD (Asp-Glu-Ala-Asp) box 201303_at 0.000547 down DDX48 polypeptide 48 NADH dehydrogenase (ubiquinone) 1 201304_at 0.000113 down NDUFA5 alpha subcomplex, 5, 13kDa acidic (leucine-rich) nuclear 201305_x_at 4.30E-05 down ANP32B phosphoprotein 32 family, member B acidic (leucine-rich) nuclear 201306_s_at 2.00E-06 down ANP32B phosphoprotein 32 family, member B 201310_s_at 4.80E-05 down C5ORF13 chromosome 5 open reading frame 13 SH3 domain binding glutamic acid-rich 201311_s_at 0.000125 down SH3BGRL protein like ATP synthase, H+ transporting, mitochondrial F1 complex, beta 201322_at 2.50E-05 down ATP5B polypeptide chaperonin containing TCP1, subunit 201326_at 3.90E-05 down CCT6A 6A (zeta 1) v-ets erythroblastosis virus E26 201328_at 5.70E-05 up ETS2 oncogene homolog 2 (avian) v-ets erythroblastosis virus E26 201329_s_at 2.00E-06 up ETS2 oncogene homolog 2 (avian) 201330_at 0.000488 down RARS arginyl-tRNA synthetase 201338_x_at 2.00E-06 down GTF3A general transcription factor IIIA 201339_s_at 2.50E-05 down SCP2 sterol carrier protein 2 201350_at 6.00E-06 up FLOT2 flotillin 2 cystatin C (amyloid angiopathy and 201360_at 3.40E-05 down CST3 cerebral hemorrhage) 201361_at 1.30E-05 down MGC5508 hypothetical protein MGC5508 201362_at 0.000293 up IVNS1ABP influenza virus NS1A binding protein 201363_s_at 7.60E-05 up IVNS1ABP influenza virus NS1A binding protein 201368_at 7.00E-06 down ZFP36L2 zinc finger protein 36, C3H type-like 2 translocation associated membrane 201398_s_at 8.00E-06 down TRAM1 protein 1

201403_s_at 2.80E-05 down MGST3 microsomal glutathione S-transferase 3 COP9 constitutive photomorphogenic 201405_s_at 1.30E-05 down COPS6 homolog subunit 6 (Arabidopsis) 201406_at 2.00E-06 down RPL36AL ribosomal protein L36a-like hydroxysteroid (17-beta) 201413_at 0.000882 down HSD17B4 dehydrogenase 4 201414_s_at 7.70E-05 down NAP1L4 nucleosome assembly protein 1-like 4 201422_at 1.00E-05 down IFI30 interferon, gamma-inducible protein 30 201423_s_at 2.00E-06 down CUL4A cullin 4A 201424_s_at 0.000132 down CUL4A cullin 4A aldehyde dehydrogenase 2 family 201425_at 4.70E-05 down ALDH2 (mitochondrial) 201429_s_at 2.00E-06 down RPL37A ribosomal protein L37a 201432_at 0.000355 down CAT catalase 201433_s_at 2.00E-06 down PTDSS1 phosphatidylserine synthase 1 TIA1 cytotoxic granule-associated RNA 201448_at 0.000519 down TIA1 binding protein BUB3 budding uninhibited by 201456_s_at 4.40E-05 down BUB3 benzimidazoles 3 homolog (yeast) BUB3 budding uninhibited by 201457_x_at 2.00E-06 down BUB3 benzimidazoles 3 homolog (yeast) BUB3 budding uninhibited by 201458_s_at 2.00E-06 down BUB3 benzimidazoles 3 homolog (yeast) 201462_at 8.20E-05 down SES1 secernin 1 201470_at 0.000104 down GSTO1 glutathione S-transferase omega 1 201479_at 0.000106 down DKC1 dyskeratosis congenita 1, dyskerin reticulocalbin 2, EF-hand calcium 201485_s_at 4.20E-05 down RCN2 binding domain reticulocalbin 2, EF-hand calcium 201486_at 2.00E-06 down RCN2 binding domain 201487_at 0.000243 down CTSC cathepsin C 201492_s_at 2.00E-06 down RPL41 ribosomal protein L41 201501_s_at 8.50E-05 down GRSF1 G-rich RNA sequence binding factor 1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 201502_s_at 2.00E-06 up NFKBIA inhibitor, alpha Ras-GTPase-activating protein SH3- 201503_at 4.00E-06 down G3BP domain-binding protein transforming growth factor, beta- 201506_at 2.00E-06 down TGFBI induced, 68kDa 201515_s_at 0.000135 down TSN translin nuclear cap binding protein subunit 2, 201517_at 0.000588 down NCBP2 20kDa translocase of outer mitochondrial 201519_at 7.00E-06 down TOMM70A membrane 70 homolog A (yeast) 201520_s_at 1.30E-05 down GRSF1 G-rich RNA sequence binding factor 1 nuclear cap binding protein subunit 2, 201521_s_at 0.000308 down NCBP2 20kDa small nuclear ribonucleoprotein 201522_x_at 2.00E-06 down SNRPN polypeptide N ubiquitin-conjugating enzyme E2N 201524_x_at 0.000386 down UBE2N (UBC13 homolog, yeast) ATPase, H+ transporting, lysosomal 201527_at 0.000104 down ATP6V1F 14kDa, V1 subunit F 201528_at 4.00E-06 down RPA1 replication protein A1, 70kDa 201529_s_at 2.00E-06 down RPA1 replication protein A1, 70kDa eukaryotic translation initiation factor 201530_x_at 0.000307 down EIF4A1 4A, isoform 1 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1- 201537_s_at 0.000142 up DUSP3 related) 201544_x_at 0.000195 down PABPN1 poly(A) binding protein, nuclear 1 201550_x_at 0.000307 down ACTG1 actin, gamma 1 201554_x_at 2.00E-06 up GYG glycogenin vesicle-associated membrane protein 2 201557_at 0.000114 down VAMP2 (synaptobrevin 2) RAE1 RNA export 1 homolog (S. 201558_at 0.000142 down RAE1 pombe) 201559_s_at 2.00E-06 up CLIC4 chloride intracellular channel 4 201560_at 4.00E-05 up CLIC4 chloride intracellular channel 4 201561_s_at 0.000795 down CLSTN1 calsyntenin 1 inhibitor of DNA binding 2, dominant 201565_s_at 8.00E-05 down ID2 negative helix-loop-helix protein inhibitor of DNA binding 2, dominant 201566_x_at 0.000757 down ID2 negative helix-loop-helix protein low molecular mass ubiquinone-binding 201568_at 0.000274 down QP-C protein (9.5kD) 201569_s_at 0.000467 down CGI-51 CGI-51 protein 201571_s_at 8.60E-05 down DCTD dCMP deaminase 201576_s_at 6.00E-06 down GLB1 galactosidase, beta 1 201581_at 4.00E-06 down DJ971N18.2 hypothetical protein DJ971N18.2 201590_x_at 2.00E-06 down ANXA2 annexin A2 201591_s_at 5.50E-05 down NISCH nischarin eukaryotic translation initiation factor 3, 201592_at 2.00E-06 down EIF3S3 subunit 3 gamma, 40kDa likely ortholog of mouse immediate 201593_s_at 0.00034 down LEREPO4 early response, erythropoietin 4 201600_at 2.00E-06 down REA repressor of estrogen receptor activity interferon induced transmembrane 201601_x_at 0.00024 up IFITM1 protein 1 (9-27) nuclear phosphoprotein similar to S. 201606_s_at 4.00E-05 down PWP1 cerevisiae PWP1 nuclear phosphoprotein similar to S. 201608_s_at 0.000117 down PWP1 cerevisiae PWP1 201613_s_at 0.000494 down RUVBL1 RuvB-like 1 (E. coli) staphylococcal nuclease domain 201622_at 8.00E-06 down SND1 containing 1 201625_s_at 0.000232 down INSIG1 insulin induced gene 1 201626_at 0.000128 down INSIG1 insulin induced gene 1 201627_s_at 0.000182 down INSIG1 insulin induced gene 1 201629_s_at 4.60E-05 down ACP1 acid phosphatase 1, soluble 201630_s_at 2.00E-06 down ACP1 acid phosphatase 1, soluble 201631_s_at 2.00E-06 up IER3 immediate early response 3 eukaryotic translation initiation factor 201632_at 8.00E-06 down EIF2B1 2B, subunit 1 alpha, 26kDa cytochrome b5 outer mitochondrial 201634_s_at 0.00013 down CYB5-M membrane precursor 201641_at 0.000104 up BST2 bone marrow stromal cell antigen 2 interferon gamma receptor 2 (interferon 201642_at 1.30E-05 up IFNGR2 gamma transducer 1) 201649_at 0.000177 up UBE2L6 ubiquitin-conjugating enzyme E2L 6 201653_at 0.000272 down CNIH cornichon homolog (Drosophila) 201656_at 1.30E-05 down ITGA6 integrin, alpha 6 acyl-CoA synthetase long-chain family 201660_at 2.00E-06 up FACL3 member 3 acyl-CoA synthetase long-chain family 201661_s_at 2.00E-06 up FACL3 member 3 acyl-CoA synthetase long-chain family 201662_s_at 1.50E-05 up FACL3 member 3 SMC4 structural maintenance of 201664_at 1.90E-05 down SMC4L1 chromosomes 4-like 1 (yeast) 201665_x_at 2.00E-06 down RPS17 ribosomal protein S17 myristoylated alanine-rich protein 201668_x_at 7.00E-06 up MARCKS kinase C substrate myristoylated alanine-rich protein 201669_s_at 1.50E-05 up MARCKS kinase C substrate myristoylated alanine-rich protein 201670_s_at 4.00E-06 up MARCKS kinase C substrate 201678_s_at 0.000141 down DC12 DC12 protein peptidase (mitochondrial processing) 201682_at 0.000675 down PMPCB beta chromosome 14 open reading frame 201684_s_at 0.000199 up C14ORF92 92 201687_s_at 2.00E-06 down API5 apoptosis inhibitor 5

201697_s_at 2.00E-06 down DNMT1 DNA (cytosine-5-)-methyltransferase 1 progesterone receptor membrane 201701_s_at 2.00E-06 down PGRMC2 component 2 protein phosphatase 1, regulatory 201703_s_at 0.000115 up PPP1R10 subunit 10 ectonucleoside triphosphate diphosphohydrolase 6 (putative 201704_at 0.000826 down ENTPD6 function) 201707_at 2.80E-05 down PXF peroxisomal biogenesis factor 19 201716_at 0.00026 up SNX1 sorting nexin 1 201717_at 1.10E-05 down MRPL49 mitochondrial ribosomal protein L49 201725_at 2.00E-06 down C10ORF7 chromosome 10 open reading frame 7 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen 201726_at 2.80E-05 down ELAVL1 R) ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen 201727_s_at 0.000744 down ELAVL1 R) NADH dehydrogenase (ubiquinone) Fe- S protein 3, 30kDa (NADH-coenzyme 201740_at 1.30E-05 down NDUFS3 Q reductase) tumor protein p53 (Li-Fraumeni 201746_at 2.00E-06 down TP53 syndrome) 201750_s_at 3.20E-05 up ECE1 endothelin converting enzyme 1 201752_s_at 2.00E-06 up ADD3 adducin 3 (gamma) 201754_at 2.00E-06 down COX6C cytochrome c oxidase subunit VIc NADH dehydrogenase (ubiquinone) Fe- S protein 5, 15kDa (NADH-coenzyme 201757_at 0.000113 down NDUFS5 Q reductase) proteasome (prosome, macropain) 201762_s_at 0.000318 down PSME2 activator subunit 2 (PA28 beta) 201769_at 0.00053 down ENTH enthoprotin small nuclear ribonucleoprotein 201770_at 0.000916 down SNRPA polypeptide A 201771_at 0.000358 down SCAMP3 secretory carrier membrane protein 3 ornithine decarboxylase antizyme 201772_at 2.00E-06 up OAZIN inhibitor 201776_s_at 0.000171 down KIAA0494 KIAA0494 gene product 201778_s_at 0.000403 down KIAA0494 KIAA0494 gene product 201779_s_at 2.60E-05 up RNF13 ring finger protein 13 201780_s_at 0.000816 down RNF13 ring finger protein 13 aryl hydrocarbon receptor interacting 201781_s_at 2.50E-05 down AIP protein solute carrier family 29 (nucleoside 201802_at 0.00013 down SLC29A1 transporters), member 1 polymerase (RNA) II (DNA directed) 201803_at 0.000125 down POLR2B polypeptide B, 140kDa SH3-domain binding protein 5 (BTK- 201810_s_at 6.70E-05 up SH3BP5 associated) SH3-domain binding protein 5 (BTK- 201811_x_at 0.000361 up SH3BP5 associated) translocase of outer mitochondrial 201812_s_at 2.00E-06 down TOMM7 membrane 7 homolog (yeast) 201818_at 0.000844 down FLJ12443 hypothetical protein FLJ12443 201826_s_at 2.00E-06 up CGI-49 CGI-49 protein STAF65(GA 201837_s_at 7.30E-05 down MMA) SPTF-associated factor 65 gamma lipase A, lysosomal acid, cholesterol 201847_at 8.00E-06 down LIPA esterase (Wolman disease) 201853_s_at 6.10E-05 down CDC25B cell division cycle 25B 201854_s_at 0.000898 down KIAA0431 KIAA0431 protein 201855_s_at 2.00E-06 down KIAA0431 KIAA0431 protein ATP-binding cassette, sub-family E 201873_s_at 1.00E-05 down ABCE1 (OABP), member 1 201875_s_at 0.000211 down MPZL1 myelin protein zero-like 1 201887_at 0.000546 down IL13RA1 interleukin 13 receptor, alpha 1 201888_s_at 4.00E-05 up IL13RA1 interleukin 13 receptor, alpha 1 IMP (inosine monophosphate) 201892_s_at 2.80E-05 down IMPDH2 dehydrogenase 2 aldo-keto reductase family 1, member 201900_s_at 9.00E-06 down AKR1A1 A1 (aldehyde reductase) 201901_s_at 0.000126 down YY1 YY1 transcription factor 201909_at 2.80E-05 down RPS4Y ribosomal protein S4, Y-linked 1 guanine nucleotide binding protein (G 201921_at 0.000823 down GNG10 protein), gamma 10 201922_at 2.00E-06 down TINP1 TGF beta-inducible nuclear protein 1 201923_at 8.00E-05 down PRDX4 peroxiredoxin 4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 201924_at 4.30E-05 up MLLT2 Drosophila); translocated to, 2 decay accelerating factor for complement (CD55, Cromer blood 201925_s_at 2.00E-06 up DAF group system) decay accelerating factor for complement (CD55, Cromer blood 201926_s_at 2.00E-06 up DAF group system) electron-transfer-flavoprotein, alpha 201931_at 0.000506 down ETFA polypeptide (glutaric aciduria II) 201934_at 3.90E-05 down PRO2730 hypothetical protein PRO2730 eukaryotic translation initiation factor 4 201935_s_at 4.90E-05 up EIF4G3 gamma, 3 eukaryotic translation initiation factor 4 201936_s_at 0.000127 up EIF4G3 gamma, 3 201937_s_at 0.000948 down DNPEP aspartyl aminopeptidase 201938_at 1.80E-05 down CDK2AP1 CDK2-associated protein 1 201939_at 0.000934 up PLK2 polo-like kinase 2 (Drosophila) 201940_at 8.00E-06 up CPD carboxypeptidase D 201941_at 1.00E-05 up CPD carboxypeptidase D 201942_s_at 9.00E-06 up CPD carboxypeptidase D 201943_s_at 2.80E-05 up CPD carboxypeptidase D 201944_at 0.000167 down HEXB hexosaminidase B (beta polypeptide) chaperonin containing TCP1, subunit 2 201946_s_at 0.000144 down CCT2 (beta) chaperonin containing TCP1, subunit 2 201947_s_at 4.70E-05 down CCT2 (beta) calcium and integrin binding 1 201953_at 2.00E-06 down CIB1 (calmyrin) 201955_at 8.70E-05 down CCNC cyclin C

201956_s_at 0.000115 down GNPAT glyceronephosphate O-acyltransferase acyl-CoA synthetase long-chain family 201963_at 9.00E-06 up FACL2 member 1 201968_s_at 6.70E-05 down PGM1 phosphoglucomutase 1 cAMP responsive element binding 201990_s_at 8.40E-05 down CREBL2 protein-like 2 heterogeneous nuclear 201993_x_at 2.00E-06 down HNRPDL ribonucleoprotein D-like 201995_at 1.10E-05 up EXT1 exostoses (multiple) 1 sialyltransferase 1 (beta-galactoside 201998_at 2.00E-06 down SIAT1 alpha-2,6-sialyltransferase) t-complex-associated-testis-expressed 201999_s_at 4.90E-05 up TCTEL1 1-like 1 NADH dehydrogenase (ubiquinone) 1 202001_s_at 7.60E-05 down NDUFA6 alpha subcomplex, 6, 14kDa protein phosphatase 1, regulatory 202014_at 2.00E-06 up PPP1R15A (inhibitor) subunit 15A LanC lantibiotic synthetase component 202020_s_at 0.000312 down LANCL1 C-like 1 (bacterial) 202023_at 0.000346 up EFNA1 ephrin-A1 arsA arsenite transporter, ATP-binding, 202024_at 0.000882 down ASNA1 homolog 1 (bacterial) 202029_x_at 2.00E-06 down RPL38 ribosomal protein L38 202039_at 4.30E-05 down TIAF1 TGFB1-induced anti-apoptotic factor 1 aldehyde dehydrogenase 3 family, 202054_s_at 0.000586 down ALDH3A2 member A2 NADH dehydrogenase (ubiquinone) 1, 202077_at 5.40E-05 down NDUFAB1 alpha/beta subcomplex, 1, 8kDa COP9 constitutive photomorphogenic 202078_at 2.00E-06 down COPS3 homolog subunit 3 (Arabidopsis) tight junction protein 2 (zona occludens 202085_at 4.90E-05 down TJP2 2) myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 202086_at 0.000952 up MX1 (mouse) solute carrier family 39 (zinc 202088_at 5.00E-06 down SLC39A6 transporter), member 6 202096_s_at 4.00E-06 up BZRP benzodiazapine receptor (peripheral) v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding 202100_at 5.80E-05 up RALB protein) v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding 202101_s_at 3.10E-05 up RALB protein) immunoglobulin (CD79A) binding 202105_at 0.000866 down IGBP1 protein 1

202106_at 0.000219 down GOLGA3 golgi autoantigen, golgin subfamily a, 3 ADP-ribosylation factor interacting 202109_at 2.00E-05 down ARFIP2 protein 2 (arfaptin 2) 202113_s_at 0.000192 down SNX2 sorting nexin 2 202114_at 0.000474 down SNX2 sorting nexin 2 adaptor-related protein complex 2, 202120_x_at 1.00E-05 down AP2S1 sigma 1 subunit amyotrophic lateral sclerosis 2 (juvenile) chromosome region, 202125_s_at 1.30E-05 down ALS2CR3 candidate 3 PRP4 pre-mRNA processing factor 4 202126_at 0.00028 down PRPF4B homolog B (yeast) PRP4 pre-mRNA processing factor 4 202127_at 0.000106 down PRPF4B homolog B (yeast) zinc finger, MYND domain containing 202136_at 2.00E-06 down BS69 11 aldo-keto reductase family 7, member 202139_at 4.20E-05 down AKR7A2 A2 (aflatoxin aldehyde reductase) COP9 constitutive photomorphogenic 202141_s_at 0.000575 down COPS8 homolog subunit 8 (Arabidopsis) 202144_s_at 2.00E-06 down ADSL adenylosuccinate lyase TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated 202168_at 2.00E-06 down TAF9 factor, 32kDa aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl 202169_s_at 0.000294 down AASDHPPT transferase 202174_s_at 0.000492 down PCM1 pericentriolar material 1 procollagen-lysine, 2-oxoglutarate 5- 202185_at 0.000829 down PLOD3 dioxygenase 3 protein phosphatase 2, regulatory 202187_s_at 0.000115 up PPP2R5A subunit B (B56), alpha isoform 202188_at 0.000969 up KIAA0095 nucleoporin 93kDa 202189_x_at 0.000396 down PTBP1 polypyrimidine tract binding protein 1 202191_s_at 2.00E-06 down GAS7 growth arrest-specific 7 202192_s_at 2.00E-06 up GAS7 growth arrest-specific 7 202193_at 0.000123 up LIMK2 LIM domain kinase 2 202198_s_at 2.00E-06 up MTMR3 myotubularin related protein 3 202199_s_at 2.00E-06 up SRPK1 SFRS protein kinase 1 202200_s_at 2.00E-06 up SRPK1 SFRS protein kinase 1 202206_at 1.30E-05 down ARL7 ADP-ribosylation factor-like 7 202207_at 2.00E-06 down ARL7 ADP-ribosylation factor-like 7 202208_s_at 2.00E-06 down ARL7 ADP-ribosylation factor-like 7 calcium homeostasis endoplasmic 202230_s_at 7.00E-04 down CHERP reticulum protein 202231_at 2.00E-06 down GA17 dendritic cell protein 202232_s_at 2.00E-06 down GA17 dendritic cell protein ubiquinol-cytochrome c reductase 202233_s_at 2.20E-05 down UQCRH hinge protein 202241_at 2.00E-06 up C8FW tribbles homolog 1 (Drosophila) signal-induced proliferation-associated 202255_s_at 5.30E-05 up SIPA1L1 1 like 1 B lymphoma Mo-MLV insertion region 202265_at 1.70E-05 down BMI1 (mouse) TRAF and TNF receptor associated 202266_at 0.000141 down TTRAP protein amyloid beta precursor protein binding 202268_s_at 1.70E-05 down APPBP1 protein 1, 59kDa guanylate binding protein 1, interferon- 202269_x_at 0.000658 up GBP1 inducible, 67kDa 202275_at 9.70E-05 up G6PD glucose-6-phosphate dehydrogenase split hand/foot malformation 202276_at 4.70E-05 down SHFM1 (ectrodactyly) type 1 hydroxyacyl-Coenzyme A 202282_at 0.000211 down HADH2 dehydrogenase, type II 202295_s_at 0.000391 up CTSH cathepsin H

202304_at 1.70E-05 up KIAA0970 fibronectin type III domain containing 3 polymerase (RNA) II (DNA directed) 202306_at 2.00E-06 down POLR2G polypeptide G 202315_s_at 0.000542 down BCR breakpoint cluster region 202326_at 9.00E-06 down BAT8 HLA-B associated transcript 8 202338_at 0.00076 up TK1 thymidine kinase 1, soluble 202364_at 2.00E-06 down MXI1 MAX interactor 1 natural killer-tumor recognition 202379_s_at 5.40E-05 down NKTR sequence natural killer-tumor recognition 202380_s_at 4.00E-06 down NKTR sequence brain abundant, membrane attached 202391_at 4.00E-06 up BASP1 signal protein 1 202392_s_at 0.000127 down PISD phosphatidylserine decarboxylase 202396_at 4.00E-05 down TCERG1 transcription elongation regulator 1 202397_at 5.80E-05 down NUTF2 nuclear transport factor 2 PRP31 pre-mRNA processing factor 31 202408_s_at 0.000134 down PRPF31 homolog (yeast) DEAH (Asp-Glu-Ala-His) box 202420_s_at 9.40E-05 down DHX9 polypeptide 9 acyl-CoA synthetase long-chain family 202422_s_at 3.50E-05 up FACL4 member 4 MYST histone acetyltransferase 202423_at 0.000202 down MYST3 (monocytic leukemia) 3 202430_s_at 4.90E-05 up PLSCR1 phospholipid scramblase 1 v-myc myelocytomatosis viral 202431_s_at 4.90E-05 down MYC oncogene homolog (avian) cytochrome P450, family 1, subfamily 202435_s_at 0.000112 down CYP1B1 B, polypeptide 1 cytochrome P450, family 1, subfamily 202436_s_at 8.00E-05 down CYP1B1 B, polypeptide 1 cytochrome P450, family 1, subfamily 202437_s_at 0.000137 up CYP1B1 B, polypeptide 1 chromosome 10 open reading frame 202441_at 1.10E-05 up C10ORF69 69 chromosome 10 open reading frame 202444_s_at 2.00E-06 up C10ORF69 69 202446_s_at 1.10E-05 up PLSCR1 phospholipid scramblase 1 6-phosphofructo-2-kinase/fructose-2,6- 202464_s_at 2.00E-06 up PFKFB3 biphosphatase 3 202466_at 0.000748 down POLS polymerase (DNA directed) sigma 202467_s_at 2.00E-06 down TRIP15 thyroid receptor interacting protein 15 isocitrate dehydrogenase 3 (NAD+) 202471_s_at 1.80E-05 down IDH3G gamma host cell factor C1 (VP16-accessory 202474_s_at 2.00E-06 down HCFC1 protein) 202475_at 2.20E-05 down NIFIE14 seven transmembrane domain protein 202478_at 8.00E-06 down TRB2 tribbles homolog 2 (Drosophila) 202487_s_at 0.000567 down H2AV H2A histone family, member V inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase 202491_s_at 8.00E-06 down IKBKAP complex-associated protein solute carrier family 2 (facilitated 202497_x_at 2.00E-06 up SLC2A3 glucose transporter), member 3 solute carrier family 2 (facilitated 202498_s_at 2.00E-06 up SLC2A14 glucose transporter), member 14 solute carrier family 2 (facilitated 202499_s_at 2.00E-06 up SLC2A3 glucose transporter), member 3 acyl-Coenzyme A dehydrogenase, C-4 202502_at 3.90E-05 down ACADM to C-12 straight chain small nuclear ribonucleoprotein 202505_at 0.000455 down SNRPB2 polypeptide B'' 202514_at 0.000261 down DLG1 discs, large homolog 1 (Drosophila) 202515_at 0.000901 down DLG1 discs, large homolog 1 (Drosophila) CCCTC-binding factor (zinc finger 202521_at 1.30E-05 down CTCF protein)

sparc/osteonectin, cwcv and kazal-like 202524_s_at 2.00E-06 down SPOCK2 domains proteoglycan (testican) 2 202530_at 2.00E-06 up MAPK14 mitogen-activated protein kinase 14 small inducible cytokine subfamily E, member 1 (endothelial monocyte- 202541_at 1.30E-05 down SCYE1 activating) small inducible cytokine subfamily E, member 1 (endothelial monocyte- 202542_s_at 2.00E-05 down SCYE1 activating) 202545_at 0.000763 up PRKCD protein kinase C, delta vesicle-associated membrane protein 8 202546_at 2.00E-06 down VAMP8 (endobrevin) DKFZP547E 202560_s_at 0.000974 down 1010 DKFZP547E1010 protein small nuclear ribonucleoprotein D3 202567_at 7.30E-05 down SNRPD3 polypeptide 18kDa high mobility group nucleosomal 202579_x_at 9.00E-06 down HMGN4 binding domain 4 nuclear transcription factor, X-box 202584_at 0.000554 down NFX1 binding 1 202591_s_at 0.000288 down SSBP1 single-stranded DNA binding protein 1 leptin receptor overlapping transcript- 202594_at 1.30E-05 down LEPROTL1 like 1 leptin receptor overlapping transcript- 202595_s_at 6.10E-05 down LEPROTL1 like 1 202599_s_at 0.000248 up NRIP1 nuclear receptor interacting protein 1 202602_s_at 8.00E-06 down HTATSF1 HIV TAT specific factor 1 202605_at 0.000647 down GUSB glucuronidase, beta N-deacetylase/N-sulfotransferase 202607_at 0.000157 down NDST1 (heparan glucosaminyl) 1 202615_at 0.000756 down 202621_at 1.10E-05 down IRF3 interferon regulatory factor 3 202624_s_at 3.50E-05 down CABIN1 calcineurin binding protein 1 polymerase (RNA) II (DNA directed) 202634_at 0.000539 down POLR2K polypeptide K, 7.0kDa polymerase (RNA) II (DNA directed) 202635_s_at 0.000262 down POLR2K polypeptide K, 7.0kDa intercellular adhesion molecule 1 202637_s_at 2.00E-06 up ICAM1 (CD54), human rhinovirus receptor 202640_s_at 0.00073 down RANBP3 RAN binding protein 3 tumor necrosis factor, alpha-induced 202643_s_at 2.00E-06 up TNFAIP3 protein 3 tumor necrosis factor, alpha-induced 202644_s_at 2.00E-06 up TNFAIP3 protein 3 202646_s_at 8.00E-06 down D1S155E NRAS-related gene 202649_x_at 2.00E-06 down RPS19 ribosomal protein S19 family with sequence similarity 34, 202651_at 0.000617 down KIAA0205 member A 202658_at 0.000123 down PEX11B peroxisomal biogenesis factor 11B proteasome (prosome, macropain) 202659_at 0.00076 down PSMB10 subunit, beta type, 10 202666_s_at 0.000228 down BAF53A BAF53 pyridoxal (pyridoxine, vitamin B6) 202671_s_at 3.00E-05 up PDXK kinase 202672_s_at 0.000973 up ATF3 activating transcription factor 3 succinate dehydrogenase complex, 202675_at 0.000986 down SDHB subunit B, iron sulfur (Ip) RAS p21 protein activator (GTPase 202677_at 0.000115 down RASA1 activating protein) 1 202683_s_at 0.000129 down RNMT RNA (guanine-7-) methyltransferase small nuclear ribonucleoprotein D1 202690_s_at 5.90E-05 down SNRPD1 polypeptide 16kDa cytochrome c oxidase subunit IV 202698_x_at 5.80E-05 down COX4I1 isoform 1 202708_s_at 0.000352 up HIST2H2BE histone 2, H2be programmed cell death 4 (neoplastic 202730_s_at 1.70E-05 up PDCD4 transformation inhibitor) programmed cell death 4 (neoplastic 202731_at 3.00E-05 down PDCD4 transformation inhibitor) LSM4 homolog, U6 small nuclear RNA 202737_s_at 1.90E-05 down LSM4 associated (S. cerevisiae) protein kinase, cAMP-dependent, 202741_at 2.00E-06 down PRKACB catalytic, beta protein kinase, cAMP-dependent, 202742_s_at 2.00E-06 down PRKACB catalytic, beta 202746_at 2.00E-06 down ITM2A integral membrane protein 2A R3H domain (binds single-stranded 202754_at 0.000358 down R3HDM nucleic acids) containing 202757_at 3.30E-05 down COBRA1 cofactor of BRCA1 family with sequence similarity 38, 202771_at 2.00E-06 down KIAA0233 member A nicotinamide nucleotide 202783_at 0.000205 down NNT transhydrogenase HRIHFB212 202795_x_at 0.000447 down 2 Tara-like protein 202820_at 0.000437 down AHR aryl hydrocarbon receptor 202836_s_at 6.80E-05 down TXNL4 thioredoxin-like 4 202837_at 1.30E-05 up FLN29 FLN29 gene product 202838_at 0.000984 down FUCA1 fucosidase, alpha-L- 1, tissue NADH dehydrogenase (ubiquinone) 1 202839_s_at 0.00032 down NDUFB7 beta subcomplex, 7, 18kDa phosphoenolpyruvate carboxykinase 2 202847_at 0.000369 down PCK2 (mitochondrial) 202849_x_at 0.000277 up GRK6 G protein-coupled receptor kinase 6 ATP-binding cassette, sub-family D 202850_at 4.00E-06 down ABCD3 (ALD), member 3 202853_s_at 0.000516 down RYK RYK receptor-like tyrosine kinase 202857_at 2.90E-05 down TMEM4 transmembrane protein 4 202859_x_at 2.80E-05 up IL8 interleukin 8 202864_s_at 0.000167 up SP100 nuclear antigen Sp100 2',5'-oligoadenylate synthetase 1, 202869_at 0.000677 up OAS1 40/46kDa ATPase, H+ transporting, lysosomal 202872_at 0.000601 up ATP6V1C1 42kDa, V1 subunit C, isoform 1 ATPase, H+ transporting, lysosomal 202874_s_at 4.30E-05 up ATP6V1C1 42kDa, V1 subunit C, isoform 1 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta 202885_s_at 0.00018 up PPP2R1B isoform CDC23 (cell division cycle 23, yeast, 202892_at 0.000601 down CDC23 homolog) protein tyrosine phosphatase, non- 202895_s_at 0.000343 up PTPNS1 receptor type substrate 1 protein tyrosine phosphatase, non- 202896_s_at 0.000261 up PTPNS1 receptor type substrate 1 202900_s_at 6.90E-05 down NUP88 nucleoporin 88kDa Nijmegen breakage syndrome 1 202905_x_at 2.80E-05 up NBS1 (nibrin) Nijmegen breakage syndrome 1 202906_s_at 2.00E-06 up NBS1 (nibrin) Nijmegen breakage syndrome 1 202907_s_at 1.50E-05 up NBS1 (nibrin) 202910_s_at 7.70E-05 down CD97 CD97 antigen 202912_at 5.40E-05 up ADM adrenomedullin 202926_at 4.70E-05 down NAG neuroblastoma-amplified protein succinate-CoA ligase, ADP-forming, 202930_s_at 0.000241 down SUCLA2 beta subunit 202931_x_at 1.00E-04 down BIN1 bridging integrator 1 202943_s_at 4.00E-06 down NAGA N-acetylgalactosaminidase, alpha- 202944_at 4.90E-05 down NAGA N-acetylgalactosaminidase, alpha- 202948_at 0.000102 up IL1R1 interleukin 1 receptor, type I dual-specificity tyrosine-(Y)- 202968_s_at 0.000101 down DYRK2 phosphorylation regulated kinase 2 dual-specificity tyrosine-(Y)- 202969_at 7.00E-06 down DYRK2 phosphorylation regulated kinase 2 dual-specificity tyrosine-(Y)- 202971_s_at 0.000263 down DYRK2 phosphorylation regulated kinase 2 HCF-binding transcription factor 202979_s_at 0.000131 down ZF Zhangfei phosphorylase, glycogen; liver (Hers disease, glycogen storage disease 202990_at 1.70E-05 up PYGL type VI) signal transducer and activator of 203010_at 0.000657 up STAT5A transcription 5A DKFZP547I 203012_x_at 2.00E-06 down 014 hypothetical protein DKFZp547I014 203028_s_at 0.000105 up CYBA cytochrome b-245, alpha polypeptide protein tyrosine phosphatase, receptor 203029_s_at 2.00E-06 down PTPRN2 type, N polypeptide 2 protein tyrosine phosphatase, receptor 203030_s_at 2.00E-06 up PTPRN2 type, N polypeptide 2 203033_x_at 9.90E-05 down FH fumarate hydratase 203034_s_at 2.00E-06 down RPL27A ribosomal protein L27a 203043_at 0.000323 down ZBED1 zinc finger, BED domain containing 1 203044_at 0.000123 up CHSY1 carbohydrate (chondroitin) synthase 1 203048_s_at 3.20E-05 down KIAA0372 KIAA0372 203049_s_at 2.00E-06 down KIAA0372 KIAA0372 3'-phosphoadenosine 5'- 203060_s_at 3.00E-05 down PAPSS2 phosphosulfate synthase 2

203062_s_at 2.70E-05 up MDC1 mediator of DNA damage checkpoint 1 protein phosphatase 1F (PP2C domain 203063_at 0.000365 down PPM1F containing) BMS1-like, ribosome assembly protein 203082_at 6.80E-05 down BMS1L (yeast) 203103_s_at 0.000156 down NMP200 PRP19/PSO4 homolog (S. cerevisiae) colony stimulating factor 1 receptor, formerly McDonough feline sarcoma 203104_at 5.00E-06 down CSF1R viral (v-fms) oncogene homolog 203107_x_at 2.00E-06 down RPS2 ribosomal protein S2 serine palmitoyltransferase, long chain 203127_s_at 0.000349 up SPTLC2 base subunit 2 203139_at 5.50E-05 down DAPK1 death-associated protein kinase 1 B-cell CLL/lymphoma 6 (zinc finger 203140_at 8.20E-05 up BCL6 protein 51) 203143_s_at 7.00E-05 up KIAA0040 KIAA0040 gene product 203156_at 2.00E-06 down AKAP11 A kinase (PRKA) anchor protein 11 solute carrier family 33 (acetyl-CoA 203164_at 0.000177 down SLC33A1 transporter), member 1 ras homolog gene family, member G 203175_at 0.000547 up ARHG (rho G) galactose-1-phosphate 203179_at 9.00E-06 down GALT uridylyltransferase 203182_s_at 0.000282 down SRPK2 SFRS protein kinase 2

S100 calcium binding protein A4 (calcium protein, calvasculin, 203186_s_at 0.00049 up S100A4 metastasin, murine placental homolog) NADH dehydrogenase (ubiquinone) Fe- S protein 8, 23kDa (NADH-coenzyme 203189_s_at 2.00E-06 down NDUFS8 Q reductase) NADH dehydrogenase (ubiquinone) Fe- S protein 8, 23kDa (NADH-coenzyme 203190_at 2.00E-06 down NDUFS8 Q reductase) 203203_s_at 0.000458 down HRB2 HIV-1 rev binding protein 2 sialyltransferase 9 (CMP- NeuAc:lactosylceramide alpha-2,3- 203217_s_at 2.50E-05 down SIAT9 sialyltransferase; GM3 synthase) 203219_s_at 2.80E-05 down APRT adenine phosphoribosyltransferase 203233_at 8.00E-06 up IL4R interleukin 4 receptor 203234_at 2.00E-06 up UPP1 uridine phosphorylase 1 lectin, galactoside-binding, soluble, 9 203236_s_at 0.000106 down LGALS9 (galectin 9) 203246_s_at 2.00E-06 down TUSC4 tumor suppressor candidate 4 DR1-associated protein 1 (negative 203258_at 0.000439 up DRAP1 cofactor 2 alpha) 203271_s_at 0.000547 down UNC119 unc-119 homolog (C. elegans) coagulation factor VIII-associated 203274_at 0.000569 down F8A (intronic transcript) 203276_at 9.00E-06 up LMNB1 lamin B1 203278_s_at 2.00E-06 down BHC80 BRAF35/HDAC2 complex (80 kDa) glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage 203282_at 4.90E-05 down GBE1 disease type IV) 203283_s_at 3.20E-05 down HS2ST1 heparan sulfate 2-O-sulfotransferase 1 203284_s_at 2.00E-06 down HS2ST1 heparan sulfate 2-O-sulfotransferase 1 203297_s_at 0.000329 down JARID2 Jumonji, AT rich interactive domain 2 203298_s_at 4.00E-06 down JARID2 Jumonji, AT rich interactive domain 2 203302_at 0.000236 down DCK deoxycytidine kinase solute carrier family 35 (CMP-sialic 203306_s_at 2.60E-05 down SLC35A1 acid transporter), member A1 TGFB-induced factor (TALE family 203313_s_at 2.00E-06 down TGIF homeobox) small nuclear ribonucleoprotein 203316_s_at 2.00E-06 down SNRPE polypeptide E 203317_at 8.10E-05 down TIC SEC7 homolog 203320_at 0.000222 down LNK lymphocyte adaptor protein inositol polyphosphate-5-phosphatase, 203332_s_at 9.60E-05 down INPP5D 145kDa 203337_x_at 0.000192 down ITGB1BP1 integrin beta 1 binding protein 1 protein phosphatase 2, regulatory 203338_at 0.000122 down PPP2R5E subunit B (B56), epsilon isoform 203356_at 7.00E-06 down CAPN7 calpain 7 NADH dehydrogenase (ubiquinone) 1 203371_s_at 0.000384 up NDUFB3 beta subcomplex, 3, 12kDa 203374_s_at 1.10E-05 down TPP2 tripeptidyl peptidase II 203375_s_at 2.00E-06 down TPP2 tripeptidyl peptidase II 203380_x_at 0.00057 down SFRS5 splicing factor, arginine/serine-rich 5 203385_at 3.20E-05 down DGKA diacylglycerol kinase, alpha 80kDa 203386_at 2.00E-06 down TBC1D4 TBC1 domain family, member 4 203387_s_at 3.90E-05 down TBC1D4 TBC1 domain family, member 4 phosphoribosyl pyrophosphate 203401_at 0.000175 down PRPS2 synthetase 2 potassium voltage-gated channel, shaker-related subfamily, beta member 203402_at 9.00E-06 down KCNAB2 2 203405_at 0.00012 down DSCR2 Down syndrome critical region gene 2 special AT-rich sequence binding protein 1 (binds to nuclear 203408_s_at 0.000175 down SATB1 matrix/scaffold-associating DNA's) damage-specific DNA binding protein 203409_at 0.000301 down DDB2 2, 48kDa 203413_at 1.70E-05 down NELL2 NEL-like 2 (chicken) 203416_at 0.000388 up CD53 CD53 antigen 203421_at 2.00E-06 up TP53I11 tumor protein p53 inducible protein 11 ASF1 anti-silencing function 1 homolog 203427_at 1.30E-05 down ASF1A A (S. cerevisiae) ASF1 anti-silencing function 1 homolog 203428_s_at 2.00E-06 down ASF1A A (S. cerevisiae) 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate 203433_at 2.00E-06 up MTHFS cyclo-ligase) membrane metallo-endopeptidase (neutral endopeptidase, 203434_s_at 2.50E-05 up MME enkephalinase, CALLA, CD10) membrane metallo-endopeptidase (neutral endopeptidase, 203435_s_at 8.00E-06 down MME enkephalinase, CALLA, CD10) 203459_s_at 0.000167 down VPS16 vacuolar protein sorting 16 (yeast) 203465_at 2.90E-05 down MRPL19 mitochondrial ribosomal protein L19 203467_at 2.80E-05 down PMM1 phosphomannomutase 1 cyclin-dependent kinase (CDC2-like) 203468_at 0.000256 down CDK10 10 203470_s_at 3.90E-05 up PLEK pleckstrin 203471_s_at 5.50E-05 up PLEK pleckstrin IQ motif containing GTPase activating 203474_at 0.000766 down IQGAP2 protein 2 203480_s_at 3.20E-05 down HSHIN1 HIV-1 induced protein HIN-1 203482_at 7.20E-05 down C10ORF6 chromosome 10 open reading frame 6 203485_at 2.00E-06 down RTN1 reticulon 1 203493_s_at 0.000179 down KIAA0092 translokin 203494_s_at 0.000277 down KIAA0092 translokin

trinucleotide repeat containing 11 (THR- 203506_s_at 0.000119 up TNRC11 associated protein, 230kDa subunit) sortilin-related receptor, L(DLR class) 203509_at 0.000332 down SORL1 A repeats-containing 203531_at 0.00031 down CUL5 cullin 5 LSM1 homolog, U6 small nuclear RNA 203534_at 0.000308 down LSM1 associated (S. cerevisiae) phosphoribosyl pyrophosphate 203537_at 1.70E-05 down PRPSAP2 synthetase-associated protein 2 203538_at 2.00E-06 down CAMLG calcium modulating ligand likely ortholog of mouse gene rich 203547_at 2.00E-06 down GRCC10 cluster, C10 gene mitogen-activated protein kinase 203552_at 3.40E-05 down MAP4K5 kinase kinase kinase 5 203558_at 0.000695 down KIAA0076 cullin 7 Fc fragment of IgG, low affinity IIa, 203561_at 3.90E-05 up FCGR2A receptor for (CD32) 203568_s_at 0.000323 up TRIM38 tripartite motif-containing 38 203574_at 2.70E-05 up NFIL3 nuclear factor, interleukin 3 regulated

203582_s_at 6.70E-05 down RAB4A RAB4A, member RAS oncogene family RNA terminal phosphate cyclase 203594_at 0.000563 down RTCD1 domain 1 aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde 203608_at 0.00049 down ALDH5A1 dehydrogenase) 203610_s_at 0.000206 up TRIM38 tripartite motif-containing 38 sulfotransferase family, cytosolic, 1A, 203615_x_at 2.10E-05 down SULT1A1 phenol-preferring, member 1 NADH dehydrogenase (ubiquinone) 1 203621_at 2.00E-06 down NDUFB5 beta subcomplex, 5, 16kDa S-phase kinase-associated protein 2 203625_x_at 9.80E-05 down SKP2 (p45) 203627_at 0.000133 up IGF1R insulin-like growth factor 1 receptor 203635_at 0.000115 down DSCR3 Down syndrome critical region gene 3 203645_s_at 2.00E-06 up CD163 CD163 antigen 203646_at 5.00E-05 down FDX1 ferredoxin 1 203647_s_at 0.000365 down FDX1 ferredoxin 1 X-ray repair complementing defective 203655_at 0.000863 down XRCC1 repair in Chinese hamster cells 1 203663_s_at 2.00E-06 down COX5A cytochrome c oxidase subunit Va 203667_at 9.80E-05 down TBCA tubulin-specific chaperone a 203675_at 0.000999 down NUCB2 nucleobindin 2 glucosamine (N-acetyl)-6-sulfatase 203676_at 3.50E-05 up GNS (Sanfilippo disease IIID) 203685_at 1.80E-05 down BCL2 B-cell CLL/lymphoma 2 tubulin, gamma complex associated 203690_at 0.000205 down TUBGCP3 protein 3 203701_s_at 0.000125 down FLJ20244 hypothetical protein FLJ20244 ras responsive element binding protein 203704_s_at 0.000852 down RREB1 1 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce 203708_at 0.000265 up PDE4B homolog, Drosophila) 203721_s_at 1.10E-05 down CGI-48 CGI-48 protein

203723_at 3.40E-05 down ITPKB inositol 1,4,5-trisphosphate 3-kinase B RNA binding motif, single stranded 203748_x_at 2.00E-06 up RBMS1 interacting protein 1 203749_s_at 0.000311 down RARA retinoic acid receptor, alpha 203752_s_at 0.000668 down JUND jun D proto-oncogene 203758_at 4.30E-05 down CTSO cathepsin O sialyltransferase 4C (beta-galactoside 203759_at 2.00E-06 up SIAT4C alpha-2,3-sialyltransferase) 203761_at 0.000748 up SLA Src-like-adaptor grancalcin, EF-hand calcium binding 203765_at 3.90E-05 up GCA protein 203773_x_at 8.00E-06 down BLVRA biliverdin reductase A 203778_at 1.30E-05 down MANBA mannosidase, beta A, lysosomal 203781_at 0.000203 down MRPL33 mitochondrial ribosomal protein L33 DEAD (Asp-Glu-Ala-Asp) box 203785_s_at 0.000626 down DDX28 polypeptide 28 type I transmembrane C-type lectin 203799_at 5.90E-05 down DCL-1 receptor DCL-1 203804_s_at 8.00E-06 down OA48-18 acid-inducible phosphoprotein 203814_s_at 0.000791 down NQO2 NAD(P)H dehydrogenase, quinone 2 203818_s_at 3.40E-05 down SF3A3 splicing factor 3a, subunit 3, 60kDa 203825_at 0.00029 down BRD3 bromodomain containing 3 203828_s_at 2.40E-05 down NK4 natural killer cell transcript 4 small nuclear ribonucleoprotein 203832_at 2.00E-06 down SNRPF polypeptide F adenosine deaminase, RNA-specific, 203865_s_at 0.000651 down ADARB1 B1 (RED1 homolog rat) TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated 203893_at 6.30E-05 down TAF9 factor, 32kDa 203897_at 2.00E-06 up LOC57149 hypothetical protein A-211C6.1 cytochrome b-245, beta polypeptide 203922_s_at 8.80E-05 up CYBB (chronic granulomatous disease) ATP synthase, H+ transporting, mitochondrial F1 complex, delta 203926_x_at 1.30E-05 down ATP5D subunit nuclear factor of kappa light polypeptide gene enhancer in B-cells 203927_at 0.000219 up NFKBIE inhibitor, epsilon major histocompatibility complex, class 203932_at 2.00E-06 down HLA-DMB II, DM beta matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV 203936_s_at 2.00E-06 up MMP9 collagenase) 203941_at 0.000925 down FLJ10871 hypothetical protein FLJ10871 203952_at 8.00E-06 up ATF6 activating transcription factor 6 203965_at 9.00E-06 down USP20 ubiquitin specific protease 20 family with sequence similarity 16, 203974_at 0.000215 down FAM16AX member A, X-linked SH3 domain containing, Ysc84-like 1 204019_s_at 2.00E-06 down SH3YL1 (S. cerevisiae) 204028_s_at 3.30E-05 down RABGAP1 RAB GTPase activating protein 1 204046_at 9.00E-06 down PLCB2 phospholipase C, beta 2 204050_s_at 0.000688 down CLTA clathrin, light polypeptide (Lca) phosphatase and tensin homolog (mutated in multiple advanced cancers 204053_x_at 0.000589 up PTEN 1) interferon consensus sequence binding 204057_at 2.00E-06 down ICSBP1 protein 1 serine/threonine kinase 3 (STE20 204068_at 2.00E-06 up STK3 homolog, yeast) 204072_s_at 7.20E-05 down 13CDNA73 hypothetical protein CG003 glycine-, glutamate-, thienylcyclohexylpiperidine-binding 204075_s_at 1.70E-05 down KIAA0562 protein 204078_at 0.000415 down SC65 synaptonemal complex protein SC65 eukaryotic translation elongation factor 204102_s_at 2.00E-06 down EEF2 2 204103_at 2.00E-06 up CCL4 chemokine (C-C motif) ligand 4 204108_at 1.70E-05 up NFYA nuclear transcription factor Y, alpha 204119_s_at 0.000141 down ADK adenosine kinase 204120_s_at 2.00E-06 down ADK adenosine kinase HSRTSBET 204142_at 0.000322 down A rTS beta protein 204145_at 0.000141 down FRG1 FSHD region gene 1 204150_at 7.00E-06 down STAB1 stabilin 1 204152_s_at 2.00E-06 down MFNG manic fringe homolog (Drosophila) 204153_s_at 2.80E-05 down MFNG manic fringe homolog (Drosophila) 204172_at 2.20E-05 down CPOX coproporphyrinogen oxidase arachidonate 5-lipoxygenase-activating 204174_at 2.00E-06 up ALOX5AP protein 204197_s_at 2.00E-06 down RUNX3 runt-related transcription factor 3 204198_s_at 8.00E-06 down RUNX3 runt-related transcription factor 3 solute carrier family 31 (copper 204204_at 0.000282 down SLC31A2 transporters), member 2 204206_at 0.00014 down MNT MAX binding protein protein kinase, interferon-inducible 204211_x_at 0.000131 up PRKR double stranded RNA dependent

204214_s_at 3.50E-05 up RAB32 RAB32, member RAS oncogene family 204215_at 2.00E-06 down C7ORF23 chromosome 7 open reading frame 23 204221_x_at 0.000113 down GLIPR1 GLI pathogenesis-related 1 (glioma) Fc fragment of IgE, high affinity I, 204232_at 1.20E-05 up FCER1G receptor for; gamma polypeptide 204234_s_at 0.000452 down ZNF195 zinc finger protein 195 GULP, engulfment adaptor PTB 204237_at 5.10E-05 up GULP1 domain containing 1 204251_s_at 0.000283 down KIAA1052 KIAA1052 protein chromodomain helicase DNA binding 204258_at 0.000199 up CHD1 protein 1 204268_at 0.000913 up S100A2 S100 calcium binding protein A2 estrogen receptor binding site 204274_at 1.90E-05 down EBAG9 associated, antigen, 9 proteasome (prosome, macropain) subunit, beta type, 9 (large 204279_at 0.00098 up PSMB9 multifunctional protease 2) phenylalanine-tRNA synthetase 1 204283_at 0.000337 up FARS1 (mitochondrial) phorbol-12-myristate-13-acetate- 204285_s_at 2.00E-06 down PMAIP1 induced protein 1 phorbol-12-myristate-13-acetate- 204286_s_at 5.10E-05 down PMAIP1 induced protein 1 204295_at 2.70E-05 down SURF1 surfeit 1 FUS interacting protein (serine-arginine 204299_at 0.000137 down FUSIP1 rich) 1 204308_s_at 0.000242 up KIAA0329 KIAA0329 204319_s_at 0.000783 down RGS10 regulator of G-protein signalling 10 204328_at 2.00E-06 down EVER1 epidermodysplasia verruciformis 1 204331_s_at 0.00013 down MRPS12 mitochondrial ribosomal protein S12 204332_s_at 0.000325 down AGA aspartylglucosaminidase ATP-binding cassette, sub-family A 204343_at 0.00012 up ABCA3 (ABC1), member 3 Ras association (RalGDS/AF-6) 204346_s_at 7.00E-06 down RASSF1 domain family 1 204351_at 2.00E-06 up S100P S100 calcium binding protein P 204352_at 2.70E-05 down TRAF5 TNF receptor-associated factor 5

204362_at 7.00E-04 down SCAP2 src family associated phosphoprotein 2 KH-type splicing regulatory protein 204372_s_at 0.000205 down KHSRP (FUSE binding protein 2) 204386_s_at 2.00E-06 down MRP63 mitochondrial ribosomal protein 63 204391_x_at 0.000898 down TIF1 transcriptional intermediary factor 1 calcium/calmodulin-dependent protein 204392_at 0.000179 down CAMK1 kinase I echinoderm microtubule associated 204399_s_at 0.000239 down EML2 protein like 2 204402_at 2.00E-06 up C22ORF3 chromosome 22 open reading frame 3 204435_at 0.000571 up NUPL1 nucleoporin like 1 204439_at 0.000357 up C1ORF29 chromosome 1 open reading frame 29 204445_s_at 9.20E-05 up ALOX5 arachidonate 5-lipoxygenase 204446_s_at 1.60E-05 up ALOX5 arachidonate 5-lipoxygenase 204452_s_at 0.000797 up FZD1 frizzled homolog 1 (Drosophila) 204470_at 1.10E-05 up CXCL2 chemokine (C-X-C motif) ligand 2 204471_at 1.10E-05 up GAP43 growth associated protein 43 204480_s_at 0.000979 down C9ORF16 chromosome 9 open reading frame 16 CD44 antigen (homing function and 204489_s_at 1.30E-05 up CD44 Indian blood group system) CD44 antigen (homing function and 204490_s_at 1.70E-05 up CD44 Indian blood group system) DKFZP434H 204494_s_at 0.000104 down 132 DKFZP434H132 protein 204502_at 2.50E-05 up SAMHD1 SAM domain and HD domain 1 engulfment and cell motility 1 (ced-12 204513_s_at 2.00E-06 down ELMO1 homolog, C. elegans) TBC1 domain family, member 8 (with 204526_s_at 2.00E-06 up TBC1D8 GRAM domain) myosin VA (heavy polypeptide 12, 204527_at 2.90E-05 up MYO5A myoxin) 204528_s_at 2.00E-06 down NAP1L1 nucleosome assembly protein 1-like 1 eukaryotic translation elongation factor 204540_at 7.40E-05 down EEF1A2 1 alpha 2 LSM7 homolog, U6 small nuclear RNA 204559_s_at 1.10E-05 down LSM7 associated (S. cerevisiae) 204560_at 2.20E-05 up FKBP5 FK506 binding protein 5 selectin L (lymphocyte adhesion 204563_at 0.00083 up SELL molecule 1) 204569_at 0.000464 down ICK intestinal cell (MAK-like) kinase

solute carrier family 7 (cationic amino 204588_s_at 2.00E-06 down SLC7A7 acid transporter, y+ system), member 7 204593_s_at 4.00E-06 down FLJ20232 hypothetical protein FLJ20232 204601_at 0.000256 up N4BP1 Nedd4 binding protein 1 204604_at 2.00E-06 up PFTK1 PFTAIRE protein kinase 1 isopentenyl-diphosphate delta 204615_x_at 1.30E-05 up IDI1 isomerase ubiquitin carboxyl-terminal esterase L3 204616_at 1.10E-05 down UCHL3 (ubiquitin thiolesterase) chondroitin sulfate proteoglycan 2 204619_s_at 0.000103 down CSPG2 (versican) chondroitin sulfate proteoglycan 2 204620_s_at 3.20E-05 down CSPG2 (versican) 204623_at 1.70E-05 up TFF3 trefoil factor 3 (intestinal) NIMA (never in mitosis gene a)-related 204634_at 0.000277 down NEK4 kinase 4 ribosomal protein S6 kinase, 90kDa, 204635_at 8.40E-05 down RPS6KA5 polypeptide 5 204639_at 2.00E-06 down ADA adenosine deaminase endothelial differentiation, sphingolipid 204642_at 0.000478 down EDG1 G-protein-coupled receptor, 1 204655_at 2.00E-06 down CCL5 chemokine (C-C motif) ligand 5

204661_at 2.00E-06 down CDW52 CDW52 antigen (CAMPATH-1 antigen) 204668_at 1.10E-05 up FTLL1 ferritin, light polypeptide-like 1 204669_s_at 0.000109 down RNF24 ring finger protein 24 major histocompatibility complex, class 204670_x_at 8.00E-06 down HLA-DRB3 II, DR beta 3 204672_s_at 4.00E-06 up ANKRD6 ankyrin repeat domain 6 204674_at 1.00E-05 down LRMP lymphoid-restricted membrane protein ATPase, Ca++ transporting, plasma 204685_s_at 0.000133 up ATP2B2 membrane 2 coagulation factor V (proaccelerin, 204713_s_at 1.10E-05 up F5 labile factor) coagulation factor V (proaccelerin, 204714_s_at 2.00E-06 up F5 labile factor) transforming growth factor, beta 204731_at 0.000129 down TGFBR3 receptor III (betaglycan, 300kDa) phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce 204735_at 0.000204 down PDE4A homolog, Drosophila) 204739_at 5.80E-05 down CENPC1 centromere protein C 1 interferon-induced protein with 204747_at 0.000977 up IFIT4 tetratricopeptide repeats 4 transporter 2, ATP-binding cassette, 204770_at 8.80E-05 up TAP2 sub-family B (MDR/TAP) transcription termination factor, RNA 204771_s_at 0.000459 down TTF1 polymerase I 204773_at 0.000385 down IL11RA interleukin 11 receptor, alpha 204774_at 2.40E-05 down EVI2A ecotropic viral integration site 2A 204777_s_at 0.00022 down MAL mal, T-cell differentiation protein nuclear receptor subfamily 2, group C, 204791_at 1.30E-05 down NR2C1 member 1 204794_at 5.60E-05 down DUSP2 dual specificity phosphatase 2 v-myb myeloblastosis viral oncogene 204798_at 0.000308 up MYB homolog (avian) Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS- 204804_at 2.50E-05 up SSA1 A/Ro) 204805_s_at 2.00E-06 down H1FX H1 histone family, member X 204820_s_at 4.90E-05 down BTN3A3 butyrophilin, subfamily 3, member A3 204821_at 3.90E-05 down BTN3A3 butyrophilin, subfamily 3, member A3 processing of precursor 5, ribonuclease P/MRP subunit (S. 204839_at 4.00E-06 down POP5 cerevisiae) MAD1 mitotic arrest deficient-like 1 204857_at 7.00E-06 down MAD1L1 (yeast) 204860_s_at 2.00E-06 up BIRC1 baculoviral IAP repeat-containing 1 204861_s_at 2.00E-06 down BIRC1 baculoviral IAP repeat-containing 1

204868_at 1.30E-05 down ICT1 immature colon carcinoma transcript 1 204873_at 7.20E-05 down PEX1 peroxisome biogenesis factor 1 204875_s_at 0.000712 down GMDS GDP-mannose 4,6-dehydratase UDP-glucose ceramide 204881_s_at 1.10E-05 up UGCG glucosyltransferase 204882_at 0.000593 down KIAA0053 Rho GTPase activating protein 25 lymphocyte-specific protein tyrosine 204890_s_at 2.00E-06 down LCK kinase lymphocyte-specific protein tyrosine 204891_s_at 2.00E-06 down LCK kinase eukaryotic translation elongation factor 204892_x_at 2.80E-05 down EEF1A1 1 alpha 1 prostaglandin E receptor 4 (subtype 204897_at 0.000291 down PTGER4 EP4) eukaryotic translation elongation factor 204905_s_at 0.000638 down EEF1E1 1 epsilon 1 204907_s_at 1.70E-05 up BCL3 B-cell CLL/lymphoma 3 204908_s_at 2.00E-06 up BCL3 B-cell CLL/lymphoma 3 solute carrier family 10 (sodium/bile 204928_s_at 1.00E-05 down SLC10A3 acid cotransporter family), member 3 vesicle-associated membrane protein 5 204929_s_at 0.000658 up VAMP5 (myobrevin) 204937_s_at 0.000445 down ZNF274 zinc finger protein 274 caspase recruitment domain family, 204950_at 0.000365 down CARD8 member 8 protein tyrosine phosphatase, receptor 204960_at 2.00E-06 down PTPRCAP type, C-associated protein neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, 204961_s_at 2.00E-06 up NCF1 autosomal 1) v-maf musculoaponeurotic fibrosarcoma oncogene homolog G 204970_s_at 6.90E-05 down MAFG (avian) 204971_at 1.50E-05 up CSTA cystatin A (stefin A) 2'-5'-oligoadenylate synthetase 2, 204972_at 2.10E-05 up OAS2 69/71kDa 205003_at 2.00E-06 up DOCK4 dedicator of cytokinesis 4 205004_at 0.000554 down NRF NF-kappa B-repressing factor 205006_s_at 1.00E-05 down NMT2 N-myristoyltransferase 2 LOH11CR2 loss of heterozygosity, 11, 205011_at 0.000644 up A chromosomal region 2, gene A 205013_s_at 1.80E-05 up ADORA2A adenosine A2a receptor 205015_s_at 0.000282 up TGFA transforming growth factor, alpha 205022_s_at 0.000184 down CHES1 checkpoint suppressor 1 signal transducer and activator of 205026_at 6.70E-05 up STAT5B transcription 5B LSM6 homolog, U6 small nuclear RNA 205036_at 0.000627 up LSM6 associated (S. cerevisiae) 205040_at 2.00E-06 up ORM2 orosomucoid 2 205041_s_at 2.00E-06 up ORM1 orosomucoid 1 CD79A antigen (immunoglobulin- 205049_s_at 0.000546 down CD79A associated alpha) integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; 205055_at 6.60E-05 down ITGAE alpha polypeptide) survival of motor neuron protein 205063_at 0.000128 down SIP1 interacting protein 1 205067_at 2.00E-06 up IL1B interleukin 1, beta X-ray repair complementing defective 205071_x_at 0.000494 up XRCC4 repair in Chinese hamster cells 4 205076_s_at 7.70E-05 down CRA cisplatin resistance associated 205081_at 2.00E-06 down CRIP1 cysteine-rich protein 1 (intestinal) 205084_at 0.000626 down BCAP29 B-cell receptor-associated protein 29 205087_at 0.000346 down RWDD3 RWD domain containing 3 205098_at 4.80E-05 up CCR1 chemokine (C-C motif) receptor 1 205099_s_at 0.000718 up CCR1 chemokine (C-C motif) receptor 1 mannosidase, alpha, class 2A, 205105_at 2.00E-06 down MAN2A1 member 1 205114_s_at 3.00E-05 up CCL3 chemokine (C-C motif) ligand 3 205115_s_at 0.000907 up KIAA0682 RNA binding motif protein 19 205119_s_at 0.00076 up FPR1 formyl peptide receptor 1 signal transducer and activator of 205170_at 1.10E-05 up STAT2 transcription 2, 113kDa protein tyrosine phosphatase, non- 205171_at 2.00E-06 down PTPN4 receptor type 4 (megakaryocyte) glutaminyl-peptide cyclotransferase 205174_s_at 1.00E-05 up QPCT (glutaminyl cyclase) a disintegrin and metalloproteinase 205180_s_at 0.000729 down ADAM8 domain 8 ATPase, Cu++ transporting, alpha 205198_s_at 0.000177 down ATP7A polypeptide (Menkes syndrome) 205209_at 0.000262 up ACVR1B activin A receptor, type IB 205212_s_at 0.000142 up CENTB1 centaurin, beta 1 205220_at 2.00E-06 up HM74 G protein-coupled receptor 109B

205227_at 2.00E-06 up IL1RAP interleukin 1 receptor accessory protein 205285_s_at 7.00E-06 up FYB FYN binding protein (FYB-120/130) CDC14 cell division cycle 14 homolog 205288_at 6.20E-05 down CDC14A A (S. cerevisiae) 205290_s_at 8.00E-04 up BMP2 bone morphogenetic protein 2 205291_at 2.00E-06 down IL2RB interleukin 2 receptor, beta CD79B antigen (immunoglobulin- 205297_s_at 9.70E-05 down CD79B associated beta) potassium inwardly-rectifying channel, 205303_at 0.000267 up KCNJ8 subfamily J, member 8 205322_s_at 2.00E-06 up MTF1 metal-regulatory transcription factor 1 205323_s_at 2.00E-06 up MTF1 metal-regulatory transcription factor 1 205324_s_at 3.90E-05 down FTSJ1 FtsJ homolog 1 (E. coli) sialyltransferase 4B (beta-galactoside 205346_at 6.10E-05 up SIAT4B alpha-2,3-sialyltransferase) 205353_s_at 2.00E-06 down PBP prostatic binding protein 205361_s_at 2.00E-06 down PFDN4 prefoldin 4 inositol polyphosphate-4-phosphatase, 205376_at 0.000105 down INPP4B type II, 105kDa MRE11 meiotic recombination 11 205395_s_at 0.000184 down MRE11A homolog A (S. cerevisiae) 205403_at 2.00E-06 up IL1R2 interleukin 1 receptor, type II 205409_at 4.00E-06 up FOSL2 FOS-like antigen 2 205418_at 8.00E-06 up FES feline sarcoma oncogene Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled 205419_at 1.00E-05 down EBI2 receptor) 205425_at 0.000342 up HIP1 huntingtin interacting protein 1 CD3E antigen, epsilon polypeptide 205456_at 2.00E-05 down CD3E (TiT3 complex) 205476_at 1.10E-05 up CCL20 chemokine (C-C motif) ligand 20 205479_s_at 0.000732 up PLAU plasminogen activator, urokinase 205486_at 0.000893 up TESK2 testis-specific kinase 2 granzyme A (granzyme 1, cytotoxic T- lymphocyte-associated serine esterase 205488_at 2.00E-06 down GZMA 3) 205494_at 0.000455 up LOC55565 hypothetical protein LOC55565 205495_s_at 1.20E-05 down GNLY granulysin sodium channel, voltage-gated, type I, 205508_at 1.10E-05 up SCN1B beta 205510_s_at 4.00E-05 down FLJ10038 hypothetical protein FLJ10038 transcobalamin I (vitamin B12 binding 205513_at 1.10E-05 up TCN1 protein, R binder family) katanin p60 (ATPase-containing) 205526_s_at 0.000236 down KATNA1 subunit A 1 205547_s_at 8.00E-06 down TAGLN transgelin 2',5'-oligoadenylate synthetase 1, 205552_s_at 0.000142 up OAS1 40/46kDa bactericidal/permeability-increasing 205557_at 2.00E-06 up BPI protein 205568_at 0.000472 up AQP9 aquaporin 9 lysosomal-associated membrane 205569_at 2.00E-06 up LAMP3 protein 3 RAS guanyl releasing protein 1 205590_at 2.00E-06 down RASGRP1 (calcium and DAG-regulated) 205607_s_at 0.00068 up PACE-1 ezrin-binding partner PACE-1 205627_at 2.00E-06 up CDA cytidine deaminase aldehyde dehydrogenase 3 family, 205640_at 0.000635 up ALDH3B1 member B1 small nuclear ribonucleoprotein 205644_s_at 0.00023 down SNRPG polypeptide G RALBP1 associated Eps domain 205645_at 3.20E-05 up REPS2 containing 2 205660_at 0.000337 up OASL 2'-5'-oligoadenylate synthetase-like aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by 205679_x_at 0.000282 up AGC1 monoclonal antibody A0122) 205681_at 2.00E-06 up BCL2A1 BCL2-related protein A1 205707_at 8.00E-05 up IL17R interleukin 17 receptor ATP synthase, H+ transporting, mitochondrial F1 complex, gamma 205711_x_at 8.00E-06 down ATP5C1 polypeptide 1 205715_at 1.70E-05 up BST1 bone marrow stromal cell antigen 1 205726_at 0.000348 up DIAPH2 diaphanous homolog 2 (Drosophila)

SH2 domain protein 1A, Duncan's 205728_at 5.80E-05 up SH2D1A disease (lymphoproliferative syndrome) 205758_at 2.00E-06 down CD8A CD8 antigen, alpha polypeptide (p32) 205781_at 2.00E-06 up C16ORF7 chromosome 16 open reading frame 7 integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage 205785_at 0.000834 up ITGAM antigen alpha polypeptide) integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage 205786_s_at 9.00E-06 up ITGAM antigen alpha polypeptide) 205789_at 2.00E-06 down CD1D CD1D antigen, d polypeptide 205791_x_at 1.10E-05 up ZNF230 zinc finger protein 230 205798_at 2.00E-06 down IL7R interleukin 7 receptor sulfotransferase family, cytosolic, 1C, 205812_s_at 0.000221 down SULT1C2 member 2 killer cell lectin-like receptor subfamily 205821_at 4.00E-06 down KLRK1 K, member 1 CD2 antigen (p50), sheep red blood 205831_at 2.00E-06 down CD2 cell receptor Janus kinase 2 (a protein tyrosine 205841_at 0.000556 up JAK2 kinase) Janus kinase 2 (a protein tyrosine 205842_s_at 5.40E-05 up JAK2 kinase) 205844_at 2.00E-06 up VNN1 vanin 1 ubiquinol-cytochrome c reductase 205849_s_at 0.000182 down UQCRB binding protein 205859_at 2.00E-06 down LY86 lymphocyte antigen 86 S100 calcium binding protein A12 205863_at 2.00E-06 up S100A12 (calgranulin C) AT rich interactive domain 3A (BRIGHT- 205865_at 9.40E-05 up ARID3A like) 205882_x_at 8.00E-06 up ADD3 adducin 3 (gamma) integrin, alpha 4 (antigen CD49D, 205884_at 2.00E-06 down ITGA4 alpha 4 subunit of VLA-4 receptor) integrin, alpha 4 (antigen CD49D, 205885_s_at 2.00E-06 down ITGA4 alpha 4 subunit of VLA-4 receptor) solute carrier family 22 (organic cation 205896_at 4.00E-06 up SLC22A4 transporter), member 4 205898_at 2.00E-06 down CX3CR1 chemokine (C-X3-C motif) receptor 1 205922_at 3.10E-05 up VNN2 vanin 2 205936_s_at 1.10E-05 up HK3 hexokinase 3 (white cell) 205961_s_at 1.50E-05 down PSIP2 PC4 and SFRS1 interacting protein 1 205978_at 0.000697 up KL klotho 205992_s_at 0.000114 down IL15 interleukin 15 tumor necrosis factor, alpha-induced 206025_s_at 2.00E-06 up TNFAIP6 protein 6 tumor necrosis factor, alpha-induced 206026_s_at 4.00E-06 up TNFAIP6 protein 6 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 206034_at 8.00E-06 up SERPINB8 8 small nuclear ribonucleoprotein 206042_x_at 4.00E-05 down SNRPN polypeptide N 206050_s_at 2.00E-06 down RNH ribonuclease/angiogenin inhibitor small nuclear ribonucleoprotein 206055_s_at 5.80E-05 down SNRPA1 polypeptide A' 206059_at 0.000106 down ZNF91 zinc finger protein 91 (HPF7, HTF10) protein tyrosine phosphatase, non- 206060_s_at 0.000753 up PTPN22 receptor type 22 (lymphoid) 206090_s_at 2.00E-06 up DISC1 disrupted in schizophrenia 1 FUS interacting protein (serine-arginine 206095_s_at 0.000226 down FUSIP1 rich) 1 206115_at 0.000782 up EGR3 early growth response 3 signal transducer and activator of 206118_at 0.000123 down STAT4 transcription 4 206133_at 0.000511 up HSXIAPAF1 XIAP associated factor-1 pentaxin-related gene, rapidly induced 206157_at 2.00E-06 up PTX3 by IL-1 beta 206175_x_at 0.00075 up ZNF222 zinc finger protein 222 206177_s_at 1.30E-05 up ARG1 arginase, liver 206200_s_at 0.000537 down ANXA11 annexin A11 206207_at 2.00E-06 down CLC Charcot-Leyden crystal protein 206208_at 2.50E-05 up CA4 carbonic anhydrase IV 206209_s_at 0.000406 up CA4 carbonic anhydrase IV phospholipase A2, group VII (platelet- activating factor acetylhydrolase, 206214_at 0.000236 down PLA2G7 plasma) 206221_at 4.40E-05 up RASA3 RAS p21 protein activator 3 complement component (3b/4b) receptor 1, including Knops blood 206244_at 9.00E-06 up CR1 group system 206245_s_at 2.00E-06 up IVNS1ABP influenza virus NS1A binding protein 206270_at 0.000256 up PRKCG protein kinase C, gamma 206272_at 0.000748 down SPHAR S-phase response (cyclin-related) mitogen-activated protein kinase 206296_x_at 9.60E-05 down MAP4K1 kinase kinase kinase 1 206324_s_at 0.000211 down DAPK2 death-associated protein kinase 2 galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, 206335_at 4.00E-06 down GALNS mucopolysaccharidosis type IVA) 206337_at 2.00E-06 down CCR7 chemokine (C-C motif) receptor 7 206359_at 9.00E-06 up SOCS3 suppressor of cytokine signaling 3 206360_s_at 1.30E-05 up SOCS3 suppressor of cytokine signaling 3 206361_at 2.00E-06 down GPR44 G protein-coupled receptor 44 206367_at 0.000295 up REN renin phosphoinositide-3-kinase, catalytic, 206369_s_at 5.30E-05 up PIK3CG gamma polypeptide 206371_at 4.30E-05 up FOLR3 folate receptor 3 (gamma) calcium channel, voltage-dependent, 206384_at 0.000328 up CACNG3 gamma subunit 3

206420_at 0.000246 up IGSF6 immunoglobulin superfamily, member 6 206440_at 0.000394 up LIN7A lin-7 homolog A (C. elegans) 206464_at 4.00E-06 up BMX BMX non-receptor tyrosine kinase 206470_at 0.000911 up PLXNC1 plexin C1 206471_s_at 0.000339 up PLXNC1 plexin C1 transducin-like enhancer of split 3 206472_s_at 0.00026 up TLE3 (E(sp1) homolog, Drosophila) CD36 antigen (collagen type I receptor, 206488_s_at 3.90E-05 down CD36 thrombospondin receptor) 206513_at 0.000108 up AIM2 absent in melanoma 2 cytochrome P450, family 4, subfamily 206514_s_at 0.000254 up CYP4F3 F, polypeptide 3 cytochrome P450, family 4, subfamily 206515_at 1.90E-05 down CYP4F3 F, polypeptide 3 maltase-glucoamylase (alpha- 206522_at 2.00E-06 up MGAM glucosidase) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, 206542_s_at 4.90E-05 down SMARCA2 subfamily a, member 2 206545_at 8.10E-05 down CD28 CD28 antigen (Tp44) 2'-5'-oligoadenylate synthetase 2, 206553_at 0.00049 up OAS2 69/71kDa 206555_s_at 9.00E-06 down FLJ20274 THUMP domain containing 1 eukaryotic translation elongation factor 206559_x_at 4.80E-05 down EEF1A1 1 alpha 1 206563_s_at 0.000538 down OPRL1 opiate receptor-like 1 mitogen-activated protein kinase 206571_s_at 2.00E-06 up MAP4K4 kinase kinase kinase 4 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary 206576_s_at 2.00E-06 up CEACAM1 glycoprotein) 206583_at 0.000357 down FLJ20344 hypothetical protein FLJ20344 206584_at 0.000179 up LY96 lymphocyte antigen 96 solute carrier family 16 (monocarboxylic acid transporters), 206600_s_at 0.000113 down SLC16A5 member 5 206618_at 2.00E-06 up IL18R1 interleukin 18 receptor 1 206636_at 0.000468 up RASA2 RAS p21 protein activator 2 206637_at 2.00E-06 up GPR105 G protein-coupled receptor 105 206656_s_at 2.00E-06 up MYOD1 myogenic factor 3 amiloride-sensitive cation channel 1, 206690_at 0.000105 up ACCN1 neuronal (degenerin) 206697_s_at 2.00E-06 up HP haptoglobin 206715_at 5.00E-05 up TFEC transcription factor EC

DNA fragmentation factor, 40kDa, beta 206752_s_at 0.00016 down DFFB polypeptide (caspase-activated DNase) 206764_x_at 2.80E-05 down MPPE1 metallophosphoesterase 1 killer cell lectin-like receptor subfamily 206785_s_at 0.000103 down KLRC1 C, member 1 SNF1 sucrose nonfermenting like 206875_s_at 3.50E-05 up SLK kinase (yeast) 206877_at 7.30E-05 up MAD MAX dimerization protein 1 leukocyte immunoglobulin-like receptor, subfamily A (without TM 206881_s_at 1.30E-05 up LILRA3 domain), member 3 206898_at 0.000468 up CDH19 cadherin 19, type 2 206911_at 4.00E-06 up ZNF147 tripartite motif-containing 25 class-I MHC-restricted T cell 206914_at 1.30E-05 down CRTAM associated molecule sialyltransferase 8D (alpha-2, 8- 206925_at 2.90E-05 up SIAT8D polysialyltransferase) 206961_s_at 0.000566 up USP49 ubiquitin specific protease 49 206978_at 5.50E-05 down delta sleep inducing peptide, 207001_x_at 8.00E-06 up DSIPI immunoreactor solute carrier family 16 (monocarboxylic acid transporters), 207038_at 0.000403 down SLC16A6 member 6

suppression of tumorigenicity 13 (colon 207040_s_at 6.70E-05 down ST13 carcinoma) (Hsp70 interacting protein) sodium channel, voltage gated, type 207049_at 5.30E-05 up SCN8A VIII, alpha 207061_at 0.000254 up ERN1 ER to nucleus signalling 1 interleukin 18 receptor accessory 207072_at 2.00E-06 up IL18RAP protein phosphatidylinositol 4-kinase, catalytic, 207081_s_at 0.00053 down PIK4CA alpha polypeptide 207094_at 1.80E-05 up IL8RA interleukin 8 receptor, alpha egf-like module containing, mucin-like, 207111_at 3.50E-05 up EMR1 hormone receptor-like 1 tumor necrosis factor (TNF 207113_s_at 0.000661 up TNF superfamily, member 2) sulfotransferase family, cytosolic, 1A, 207122_x_at 3.10E-05 down SULT1A1 phenol-preferring, member 1 207132_x_at 9.00E-06 down PFDN5 prefoldin 5 v-akt murine thymoma viral oncogene 207163_s_at 0.000354 down AKT1 homolog 1 Janus kinase 3 (a protein tyrosine 207187_at 0.000181 up JAK3 kinase, leukocyte) carcinoembryonic antigen-related cell 207205_at 0.00046 up CEACAM4 adhesion molecule 4 protein tyrosine phosphatase, receptor 207238_s_at 6.90E-05 up PTPRC type, C RNA binding motif, single stranded 207266_x_at 2.00E-06 up RBMS1 interacting protein 1 acyl-CoA synthetase long-chain family 207275_s_at 2.00E-06 up FACL2 member 1 207279_s_at 5.10E-05 up NEBL nebulette 207374_at 8.00E-06 up PLSCR2 phospholipid scramblase 2 207384_at 2.00E-06 up PGLYRP peptidoglycan recognition protein 1 207387_s_at 3.90E-05 up GK glycerol kinase glycoprotein Ib (platelet), alpha 207389_at 0.000348 down GP1BA polypeptide degenerative spermatocyte homolog, 207431_s_at 4.60E-05 up DEGS lipid desaturase (Drosophila) 207446_at 0.00076 up TLR6 toll-like receptor 6 207460_at 2.80E-05 down GZMM granzyme M (lymphocyte met-ase 1) caspase 5, apoptosis-related cysteine 207500_at 2.00E-06 up CASP5 protease ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c 207507_s_at 1.80E-05 down ATP5G3 (subunit 9) isoform 3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c 207508_at 1.70E-05 down ATP5G3 (subunit 9) isoform 3

207522_s_at 1.30E-05 down ATP2A3 ATPase, Ca++ transporting, ubiquitous nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 207535_s_at 0.000141 up NFKB2 (p49/p100) 207541_s_at 2.00E-05 down PMSCL2 exosome component 10 male-specific lethal 3-like 1 207551_s_at 2.00E-06 up MSL3L1 (Drosophila) 207556_s_at 9.00E-06 down DGKZ diacylglycerol kinase, zeta 104kDa major histocompatibility complex, class 207565_s_at 3.40E-05 up MR1 I-related ATP synthase, H+ transporting, 207573_x_at 0.000344 down ATP5L mitochondrial F0 complex, subunit g growth arrest and DNA-damage- 207574_s_at 0.00096 up GADD45B inducible, beta 5-hydroxytryptamine (serotonin) 207578_s_at 1.10E-05 up HTR4 receptor 4 207585_s_at 4.80E-05 down RPL36AL ribosomal protein L36a-like sulfotransferase family, cytosolic, 1B, 207601_at 1.50E-05 up SULT1B1 member 1 egf-like module containing, mucin-like, 207610_s_at 2.00E-06 down EMR2 hormone receptor-like 2 207614_s_at 0.00057 down CUL1 cullin 1 207630_s_at 0.000111 up CREM cAMP responsive element modulator muscle, skeletal, receptor tyrosine 207632_at 0.000416 up MUSK kinase 207640_x_at 0.000265 up NTN2L netrin 2-like (chicken) thioredoxin domain containing 7 207668_x_at 0.000286 down P5 (protein disulfide isomerase) vitelliform macular dystrophy (Best 207671_s_at 0.000263 up VMD2 disease, bestrophin) 207674_at 2.00E-06 up FCAR Fc fragment of IgA, receptor for 207681_at 0.000375 down CXCR3 chemokine (C-X-C motif) receptor 3 caspase 8, apoptosis-related cysteine 207686_s_at 0.000518 up CASP8 protease ectonucleoside triphosphate 207691_x_at 1.10E-05 up ENTPD1 diphosphohydrolase 1 207703_at 0.000657 up NLGN4 neuroligin 4, X-linked 207704_s_at 2.00E-06 up GAS7 growth arrest-specific 7 histidine triad nucleotide binding 207721_x_at 2.00E-06 down HINT1 protein 1 DKFZP586A 207761_s_at 2.00E-06 down 0522 DKFZP586A0522 protein homeodomain interacting protein 207764_s_at 0.000356 up HIPK3 kinase 3 207782_s_at 0.00088 up PSEN1 presenilin 1 (Alzheimer disease 3) recombining binding protein 207785_s_at 8.20E-05 down RBPSUH suppressor of hairless (Drosophila) 207801_s_at 2.00E-06 up RNF10 ring finger protein 10 207802_at 2.00E-06 up CRISP3 cysteine-rich secretory protein 3 pre-B-cell leukemia transcription factor 207838_x_at 1.80E-05 up PBXIP1 interacting protein 1 207856_s_at 2.70E-05 down FLJ20297 hypothetical protein FLJ20297 207921_x_at 0.000665 up PAX8 paired box gene 8 207925_at 0.000205 down CST5 cystatin D RNA binding protein S1, serine-rich 207939_x_at 0.000328 down RNPS1 domain 207957_s_at 0.000524 down PRKCB1 protein kinase C, beta 1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal 207980_s_at 0.000137 down CITED2 domain, 2 protein tyrosine phosphatase, non- 208010_s_at 0.000369 up PTPN22 receptor type 22 (lymphoid) REV3-like, catalytic subunit of DNA 208070_s_at 0.000114 down REV3L polymerase zeta (yeast) 208073_x_at 4.00E-06 down TTC3 tetratricopeptide repeat domain 3 adaptor-related protein complex 2, 208074_s_at 9.10E-05 down AP2S1 sigma 1 subunit 208094_s_at 0.000693 down MGC10471 hypothetical protein MGC10471 208095_s_at 3.30E-05 down SRP72 signal recognition particle 72kDa pregnancy specific beta-1-glycoprotein 208106_x_at 0.000184 up PSG1 1 ARC/mediator transcriptional 208110_x_at 0.000509 down TCBAP0758 coactivator subunit 208112_x_at 2.00E-06 up EHD1 EH-domain containing 1 208113_x_at 4.00E-06 down PABPC1 poly(A) binding protein, cytoplasmic 1 mannosidase, alpha, class 1A, 208116_s_at 0.000195 up MAN1A1 member 1 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 208124_s_at 0.000806 up SEMA4F (semaphorin) 4F 208128_x_at 0.000888 up KIF25 kinesin family member 25 208146_s_at 2.00E-06 down CPVL carboxypeptidase, vitellogenic-like 208158_s_at 0.000506 up OSBPL1A oxysterol binding protein-like 1A 208164_s_at 4.90E-05 up IL9R interleukin 9 receptor 208180_s_at 1.10E-05 up HIST1H4H histone 1, H4h RAS guanyl releasing protein 2 208206_s_at 0.000653 down RASGRP2 (calcium and DAG-regulated) 208223_s_at 0.000842 up ACVR1B activin A receptor, type IB 208260_at 0.000665 up AVPR1B arginine vasopressin receptor 1B arginyl aminopeptidase 208270_s_at 5.00E-05 down RNPEP (aminopeptidase B) tumor necrosis factor, alpha-induced 208296_x_at 4.00E-06 down GG2-1 protein 8 208304_at 2.00E-06 down CCR3 chemokine (C-C motif) receptor 3 major histocompatibility complex, class 208306_x_at 2.50E-05 down HLA-DRB3 II, DR beta 3 208308_s_at 2.80E-05 down GPI glucose phosphate isomerase mucosa associated lymphoid tissue 208309_s_at 2.80E-05 down MALT1 lymphoma translocation gene 1 208336_s_at 5.60E-05 down GPSN2 glycoprotein, synaptic 2 208370_s_at 0.000608 down DSCR1 Down syndrome critical region gene 1 208379_x_at 0.00069 up NPY2R neuropeptide Y receptor Y2 208392_x_at 3.00E-05 up SP110 SP110 nuclear body protein DKFZP564D putative ankyrin-repeat containing 208425_s_at 0.000361 up 166 protein 208436_s_at 0.000517 up IRF7 interferon regulatory factor 7 Gardner-Rasheed feline sarcoma viral 208438_s_at 0.000575 up FGR (v-fgr) oncogene homolog lectin, galactoside-binding, soluble, 2 208450_at 1.50E-05 down LGALS2 (galectin 2) 208470_s_at 2.00E-06 up HP haptoglobin CASP8 and FADD-like apoptosis 208485_x_at 0.000124 up CFLAR regulator complement component (3b/4b) receptor 1, including Knops blood 208488_s_at 2.00E-06 up CR1 group system 208491_s_at 0.000514 up PGM5 phosphoglucomutase 5 208517_x_at 2.00E-06 down BTF3 basic transcription factor 3 208546_x_at 0.000172 up HIST1H2BK histone 1, H2bk 208547_at 0.00023 up HIST1H2BK histone 1, H2bk 208549_x_at 2.00E-06 down PTMAP7 prothymosin, alpha pseudogene 7 208572_at 0.000643 up HIST3H3 histone 3, H3 208583_x_at 2.80E-05 up HIST1H2AJ histone 1, H2aj 208585_at 0.000103 up BTN2A1 butyrophilin, subfamily 2, member A1 protein tyrosine phosphatase type IVA, 208615_s_at 6.80E-05 down PTP4A2 member 2 protein tyrosine phosphatase type IVA, 208617_s_at 2.00E-06 down PTP4A2 member 2 damage-specific DNA binding protein 208619_at 0.000358 down DDB1 1, 127kDa nuclease sensitive element binding 208627_s_at 1.80E-05 down NSEP1 protein 1 nuclease sensitive element binding 208628_s_at 2.00E-06 down NSEP1 protein 1 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha 208631_s_at 1.80E-05 down HADHA subunit 208634_s_at 1.80E-05 down MACF1 microtubule-actin crosslinking factor 1 nascent-polypeptide-associated 208635_x_at 2.00E-06 down NACA complex alpha polypeptide thioredoxin domain containing 7 208639_x_at 0.00019 down P5 (protein disulfide isomerase) 208645_s_at 2.00E-06 down RPS14 ribosomal protein S14 208646_at 2.00E-06 down RPS14 ribosomal protein S14 CD24 antigen (small cell lung 208650_s_at 4.10E-05 up CD24 carcinoma cluster 4 antigen) 208657_s_at 0.000104 down MSF MLL septin-like fusion

suppression of tumorigenicity 13 (colon 208667_s_at 0.000577 down ST13 carcinoma) (Hsp70 interacting protein) high-mobility group nucleosomal 208668_x_at 2.00E-06 down HMGN2 binding domain 2 208669_s_at 2.00E-06 down CRI1 CREBBP/EP300 inhibitor 1 208670_s_at 2.90E-05 down CRI1 CREBBP/EP300 inhibitor 1 dolichyl-diphosphooligosaccharide- 208674_x_at 2.40E-05 down DDOST protein glycosyltransferase dolichyl-diphosphooligosaccharide- 208675_s_at 2.00E-06 down DDOST protein glycosyltransferase 208680_at 8.00E-06 down PRDX1 peroxiredoxin 1 208683_at 2.00E-06 down CAPN2 calpain 2, (m/II) large subunit 208689_s_at 4.20E-05 down RPN2 ribophorin II 208692_at 2.00E-06 down RPS3 ribosomal protein S3 208693_s_at 0.000806 down GARS glycyl-tRNA synthetase 208695_s_at 2.00E-06 down RPL39 ribosomal protein L39 eukaryotic translation initiation factor 3, 208697_s_at 2.00E-06 down EIF3S6 subunit 6 48kDa non-POU domain containing, octamer- 208698_s_at 4.80E-05 down NONO binding transketolase (Wernicke-Korsakoff 208699_x_at 2.00E-05 down TKT syndrome) transketolase (Wernicke-Korsakoff 208700_s_at 2.50E-05 down TKT syndrome)

208705_s_at 0.000314 down EIF5 eukaryotic translation initiation factor 5 heterogeneous nuclear 208713_at 8.00E-05 down E1B-AP5 ribonucleoprotein U-like 1 NADH dehydrogenase (ubiquinone) 208714_at 2.00E-06 down NDUFV1 flavoprotein 1, 51kDa oxidase (cytochrome c) assembly 1- 208717_at 2.00E-06 down OXA1L like

208721_s_at 2.70E-05 down ANAPC5 anaphase promoting complex subunit 5

208722_s_at 2.00E-06 down ANAPC5 anaphase promoting complex subunit 5 SMT3 suppressor of mif two 3 homolog 208738_x_at 0.00011 down SMT3H2 2 (yeast) 208742_s_at 0.000345 down SAP18 sin3-associated polypeptide, 18kDa ATP synthase, H+ transporting, 208745_at 6.00E-06 down ATP5L mitochondrial F0 complex, subunit g 208748_s_at 1.10E-05 up FLOT1 flotillin 1 208749_x_at 2.00E-06 up FLOT1 flotillin 1 N-ethylmaleimide-sensitive factor 208751_at 0.000254 up NAPA attachment protein, alpha 208752_x_at 2.00E-06 down NAP1L1 nucleosome assembly protein 1-like 1 208753_s_at 8.00E-06 down NAP1L1 nucleosome assembly protein 1-like 1 208754_s_at 2.00E-06 down NAP1L1 nucleosome assembly protein 1-like 1 eukaryotic translation initiation factor 3, 208756_at 0.000318 down EIF3S2 subunit 2 beta, 36kDa 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP 208758_at 0.000997 down ATIC cyclohydrolase ubiquitin-conjugating enzyme E2I 208760_at 1.30E-05 down UBE2I (UBC9 homolog, yeast) delta sleep inducing peptide, 208763_s_at 2.00E-05 down DSIPI immunoreactor ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c 208764_s_at 2.00E-06 down ATP5G2 (subunit 9), isoform 2 heterogeneous nuclear 208765_s_at 0.000262 up HNRPR ribonucleoprotein R heterogeneous nuclear 208766_s_at 1.30E-05 down HNRPR ribonucleoprotein R 208768_x_at 2.00E-06 down RPL22 ribosomal protein L22 208771_s_at 2.90E-05 down LTA4H leukotriene A4 hydrolase 208781_x_at 1.90E-05 up SNX3 sorting nexin 3 208787_at 2.00E-06 down MRPL3 mitochondrial ribosomal protein L3 MCM7 minichromosome maintenance 208795_s_at 6.80E-05 down MCM7 deficient 7 (S. cerevisiae) 208796_s_at 1.10E-05 down CCNG1 cyclin G1 208798_x_at 2.00E-06 down GOLGIN-67 golgin-67 208800_at 9.90E-05 down SRP72 signal recognition particle 72kDa 208803_s_at 0.00053 down SRP72 signal recognition particle 72kDa 208804_s_at 1.50E-05 down SFRS6 splicing factor, arginine/serine-rich 6 208808_s_at 1.30E-05 up HMGB2 high-mobility group box 2 208822_s_at 3.80E-05 down DAP3 death associated protein 3 208825_x_at 2.00E-06 down RPL23A ribosomal protein L23a histidine triad nucleotide binding 208826_x_at 2.00E-06 down HINT1 protein 1 polymerase (DNA directed), epsilon 3 208828_at 1.70E-05 down POLE3 (p17 subunit) 208829_at 0.000283 up TAPBP TAP binding protein (tapasin) 208833_s_at 7.20E-05 down E46L like mouse brain protein E46 cadherin 1, type 1, E-cadherin 208834_x_at 2.00E-06 down CDH1 (epithelial) ATPase, Na+/K+ transporting, beta 3 208836_at 3.40E-05 down ATP1B3 polypeptide 208845_at 4.00E-06 down VDAC3 voltage-dependent anion channel 3 alcohol dehydrogenase 5 (class III), chi 208847_s_at 7.70E-05 down ADH5 polypeptide 208856_x_at 2.00E-06 down RPLP0 ribosomal protein, large, P0 likely ortholog of mouse membrane 208858_s_at 2.00E-06 down MBC2 bound C2 domain containing protein 208864_s_at 4.00E-06 up TXN thioredoxin ATP synthase, H+ transporting, mitochondrial F1 complex, gamma 208870_x_at 8.00E-06 down ATP5C1 polypeptide 1 isopentenyl-diphosphate delta 208881_x_at 1.10E-05 up IDI1 isomerase eukaryotic translation initiation factor 3, 208887_at 2.00E-06 down EIF3S4 subunit 4 delta, 44kDa 208890_s_at 2.00E-06 down PLXNB2 plexin B2 208891_at 0.000304 down DUSP6 dual specificity phosphatase 6 208892_s_at 0.000441 down DUSP6 dual specificity phosphatase 6 major histocompatibility complex, class 208894_at 2.00E-06 down HLA-DRA II, DR alpha DEAD (Asp-Glu-Ala-Asp) box 208895_s_at 2.20E-05 down DDX18 polypeptide 18 DEAD (Asp-Glu-Ala-Asp) box 208896_at 6.80E-05 down DDX18 polypeptide 18 208904_s_at 2.00E-06 down RPS28 ribosomal protein S28 208905_at 2.90E-05 down CYCS cytochrome c, somatic complement component 1, q 208910_s_at 0.00026 down C1QBP subcomponent binding protein pyruvate dehydrogenase (lipoamide) 208911_s_at 3.20E-05 down PDHB beta golgi associated, gamma adaptin ear 208913_at 0.000319 down GGA2 containing, ARF binding protein 2 golgi associated, gamma adaptin ear 208914_at 0.000293 down GGA2 containing, ARF binding protein 2

208923_at 4.00E-06 down CYFIP1 cytoplasmic FMR1 interacting protein 1 208928_at 2.00E-06 up POR P450 (cytochrome) oxidoreductase 208929_x_at 2.00E-06 down RPL13 ribosomal protein L13 interleukin enhancer binding factor 3, 208930_s_at 0.00049 down ILF3 90kDa lectin, galactoside-binding, soluble, 8 208933_s_at 0.000358 down LGALS8 (galectin 8) lectin, galactoside-binding, soluble, 8 208934_s_at 2.00E-06 up LGALS8 (galectin 8) lectin, galactoside-binding, soluble, 8 208935_s_at 0.000526 down LGALS8 (galectin 8) lectin, galactoside-binding, soluble, 8 208936_x_at 4.90E-05 up LGALS8 (galectin 8) 208956_x_at 2.00E-06 down DUT dUTP pyrophosphatase

208965_s_at 8.80E-05 up IFI16 interferon, gamma-inducible protein 16

208966_x_at 0.000846 up IFI16 interferon, gamma-inducible protein 16 208968_s_at 8.00E-06 down LOC57019 hypothetical protein LOC57019 208970_s_at 1.80E-05 down UROD uroporphyrinogen decarboxylase ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c 208972_s_at 0.00037 down ATP5G1 (subunit 9), isoform 1 208974_x_at 0.000615 up KPNB1 karyopherin (importin) beta 1 208980_s_at 4.30E-05 down UBC ubiquitin C platelet/endothelial cell adhesion 208981_at 2.00E-06 down PECAM1 molecule (CD31 antigen) platelet/endothelial cell adhesion 208982_at 2.00E-06 down PECAM1 molecule (CD31 antigen) platelet/endothelial cell adhesion 208983_s_at 2.00E-06 down PECAM1 molecule (CD31 antigen) eukaryotic translation initiation factor 3, 208985_s_at 6.70E-05 down EIF3S1 subunit 1 alpha, 35kDa signal transducer and activator of transcription 3 (acute-phase response 208992_s_at 0.000128 up STAT3 factor) uncoupling protein 2 (mitochondrial, 208997_s_at 1.70E-05 down UCP2 proton carrier) uncoupling protein 2 (mitochondrial, 208998_at 2.00E-06 down UCP2 proton carrier) DKFZP566D anaphase promoting complex subunit 209001_s_at 2.00E-06 down 193 13

209009_at 0.000178 down ESD esterase D/formylglutathione hydrolase synaptotagmin binding, cytoplasmic 209024_s_at 0.000144 down SYNCRIP RNA interacting protein OK/SW- 209026_x_at 6.80E-05 up CL.56 beta 5-tubulin malate dehydrogenase 2, NAD 209036_s_at 2.00E-06 down MDH2 (mitochondrial) 209037_s_at 2.00E-06 up EHD1 EH-domain containing 1 209038_s_at 2.00E-06 up EHD1 EH-domain containing 1 209039_x_at 2.00E-06 up EHD1 EH-domain containing 1 GABARAPL GABA(A) receptor-associated protein- 209046_s_at 2.50E-05 up 2 like 2 209049_s_at 4.00E-06 down PRKCBP1 protein kinase C binding protein 1 endothelial differentiation-related factor 209058_at 1.30E-05 down EDF1 1 endothelial differentiation-related factor 209059_s_at 1.10E-05 down EDF1 1 ubiquinol-cytochrome c reductase 209066_x_at 0.00076 down UQCRB binding protein heterogeneous nuclear 209067_s_at 2.00E-06 down HNRPDL ribonucleoprotein D-like heterogeneous nuclear 209068_at 0.000644 down HNRPDL ribonucleoprotein D-like 209080_x_at 0.000295 down TXNL2 thioredoxin-like 2 209091_s_at 8.00E-06 up SH3GLB1 SH3-domain GRB2-like endophilin B1 209092_s_at 2.00E-06 down CGI-150 CGI-150 protein nucleolar protein family A, member 2 209104_s_at 4.00E-06 down NOLA2 (H/ACA small nucleolar RNPs) 209105_at 0.00073 up NCOA1 nuclear receptor coactivator 1 209107_x_at 9.00E-05 down NCOA1 nuclear receptor coactivator 1 cyclin-dependent kinase inhibitor 1B 209112_at 9.00E-06 down CDKN1B (p27, Kip1) 209113_s_at 0.000167 down HMG20B high-mobility group 20B 209123_at 3.90E-05 down QDPR quinoid dihydropteridine reductase squamous cell carcinoma antigen 209128_s_at 7.20E-05 down SART3 recognised by T cells 3 209134_s_at 2.00E-06 down RPS6 ribosomal protein S6 209137_s_at 9.30E-05 up USP10 ubiquitin specific protease 10 209138_x_at 3.90E-05 down IGLJ3 immunoglobulin lambda joining 3 ubiquitin-conjugating enzyme E2G 1 209141_at 0.000861 down UBE2G1 (UBC7 homolog, C. elegans) chloride channel, nucleotide-sensitive, 209143_s_at 2.00E-06 down CLNS1A 1A transmembrane 9 superfamily member 209149_s_at 0.000369 up TM9SF1 1 transcription factor 3 (E2A immunoglobulin enhancer binding 209153_s_at 0.00082 down TCF3 factors E12/E47) Tax1 (human T-cell leukemia virus type 209154_at 0.000251 down TIP-1 I) binding protein 3 Rab geranylgeranyltransferase, beta 209181_s_at 3.80E-05 down RABGGTB subunit 209184_s_at 0.000413 up IRS2 insulin receptor substrate 2 209185_s_at 0.000242 down IRS2 insulin receptor substrate 2 MADS box transcription enhancer factor 2, polypeptide C (myocyte 209199_s_at 1.00E-05 down MEF2C enhancer factor 2C) 209201_x_at 0.000598 up CXCR4 chemokine (C-X-C motif) receptor 4 SEC22 vesicle trafficking protein-like 1 209206_at 1.70E-05 up SEC22L1 (S. cerevisiae) SEC22 vesicle trafficking protein-like 1 209207_s_at 0.000748 up SEC22L1 (S. cerevisiae) 209211_at 4.00E-06 up KLF5 Kruppel-like factor 5 (intestinal) 209234_at 1.10E-05 up KIF1B kinesin family member 1B 209238_at 0.000785 up STX3A syntaxin 3A O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N- acetylglucosamine:polypeptide-N- 209240_at 0.000117 down OGT acetylglucosaminyl transferase) degenerative spermatocyte homolog, 209250_at 0.000428 up DEGS lipid desaturase (Drosophila) 209251_x_at 0.000637 up TUBA6 tubulin alpha 6 209265_s_at 2.70E-05 down METTL3 methyltransferase like 3 solute carrier family 39 (zinc 209267_s_at 0.000369 up SLC39A8 transporter), member 8 209268_at 2.80E-05 down VPS45A vacuolar protein sorting 45A (yeast)

209285_s_at 2.50E-05 down RAP140 retinoblastoma-associated protein 140 CDC42 effector protein (Rho GTPase 209286_at 0.000556 up CDC42EP3 binding) 3 CDC42 effector protein (Rho GTPase 209287_s_at 2.00E-06 up CDC42EP3 binding) 3 CDC42 effector protein (Rho GTPase 209288_s_at 0.000258 up CDC42EP3 binding) 3 DKFZP566B 209300_s_at 0.00013 up 183 DKFZP566B183 protein polymerase (RNA) II (DNA directed) 209302_at 0.000492 down POLR2H polypeptide H NADH dehydrogenase (ubiquinone) Fe- S protein 4, 18kDa (NADH-coenzyme 209303_at 2.00E-06 down NDUFS4 Q reductase) growth arrest and DNA-damage- 209304_x_at 0.000337 up GADD45B inducible, beta growth arrest and DNA-damage- 209305_s_at 9.10E-05 up GADD45B inducible, beta major histocompatibility complex, class 209312_x_at 1.30E-05 down HLA-DRB1 II, DR beta 1 protein-kinase, interferon-inducible double stranded RNA dependent 209323_at 2.00E-06 down PRKRIR inhibitor, repressor of (P58 repressor) 209329_x_at 2.00E-06 down MGC2198 hypothetical protein MGC2198 heterogeneous nuclear ribonucleoprotein D (AU-rich element 209330_s_at 0.000948 down HNRPD RNA binding protein 1, 37kDa) 209337_at 4.00E-06 down PSIP2 PC4 and SFRS1 interacting protein 1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog 209348_s_at 2.80E-05 down MAF (avian) SIN3 homolog B, transcriptional 209352_s_at 0.000935 down SIN3B regulator (yeast) Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal 209357_at 0.000375 down CITED2 domain, 2 209369_at 2.00E-06 up ANXA3 annexin A3 xeroderma pigmentosum, 209375_at 2.00E-06 down XPC complementation group C high mobility group nucleosomal 209377_s_at 2.00E-06 down HMGN3 binding domain 3 chitinase 3-like 1 (cartilage 209395_at 0.000197 down CHI3L1 glycoprotein-39) chitinase 3-like 1 (cartilage 209396_s_at 0.000657 down CHI3L1 glycoprotein-39) 209412_at 0.000568 down TMEM1 transmembrane protein 1 209417_s_at 8.00E-06 up IFI35 interferon-induced protein 35 chromosome 22 open reading frame 209418_s_at 1.00E-04 down C22ORF19 19

BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 209430_at 0.000903 down BTAF1 (Mot1 homolog, S. cerevisiae) rho/rac guanine nucleotide exchange 209435_s_at 0.000455 down ARHGEF2 factor (GEF) 2 phosphoribosyl pyrophosphate 209440_at 2.40E-05 down PRPS1 synthetase 1 209457_at 0.000277 up DUSP5 dual specificity phosphatase 5 209460_at 2.90E-05 down ABAT 4-aminobutyrate aminotransferase MAP kinase interacting 209467_s_at 0.00023 up MKNK1 serine/threonine kinase 1 209471_s_at 0.000992 down FNTA farnesyltransferase, CAAX box, alpha ectonucleoside triphosphate 209474_s_at 0.000193 up ENTPD1 diphosphohydrolase 1 209485_s_at 1.30E-05 up OSBPL1A oxysterol binding protein-like 1A 209486_at 1.30E-05 down SAS10 disrupter of silencing 10 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary 209498_at 2.00E-06 up CEACAM1 glycoprotein) proteasome (prosome, macropain) 26S 209503_s_at 0.000126 down PSMC5 subunit, ATPase, 5 CASP8 and FADD-like apoptosis 209508_x_at 7.50E-05 up CFLAR regulator 209512_at 0.000428 up MGC10940 chromosome 9 open reading frame 99 RAB27A, member RAS oncogene 209514_s_at 2.00E-06 up RAB27A family RAB27A, member RAS oncogene 209515_s_at 1.00E-05 up RAB27A family Rac/Cdc42 guanine nucleotide 209539_at 1.80E-05 down ARHGEF6 exchange factor (GEF) 6 receptor-interacting serine-threonine 209545_s_at 0.000614 up RIPK2 kinase 2 209553_at 0.000158 down KIAA0804 KIAA0804 protein CD36 antigen (collagen type I receptor, 209555_s_at 2.20E-05 down CD36 thrombospondin receptor) 209556_at 0.000492 down NCDN neurochondrin calmodulin 1 (phosphorylase kinase, 209563_x_at 0.000291 down CALM1 delta) zinc finger protein 183 (RING finger, 209565_at 2.00E-06 down ZNF183 C3HC4 type) RRS1 ribosome biogenesis regulator 209567_at 4.90E-05 down RRS1 homolog (S. cerevisiae) 209575_at 3.30E-05 up IL10RB interleukin 10 receptor, beta apolipoprotein B mRNA editing 209584_x_at 1.70E-05 down APOBEC3C enzyme, catalytic polypeptide-like 3C 209593_s_at 0.00013 up TOR1B torsin family 1, member B (torsin B) 209602_s_at 1.80E-05 down GATA3 GATA binding protein 3 209604_s_at 1.30E-05 down GATA3 GATA binding protein 3 sulfotransferase family, cytosolic, 1A, 209607_x_at 0.000236 down SULT1A3 phenol-preferring, member 3 carboxylesterase 1 (monocyte/macrophage serine 209616_s_at 2.80E-05 up CES1 esterase 1) CD74 antigen (invariant polypeptide of major histocompatibility complex, class 209619_at 2.00E-06 down CD74 II antigen-associated) ATP-binding cassette, sub-family B 209620_s_at 0.000977 down ABCB7 (MDR/TAP), member 7 209625_at 0.000171 down PIGH phosphatidylinositol glycan, class H nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 209636_at 0.000162 up NFKB2 (p49/p100) 209640_at 0.000552 up PML promyelocytic leukemia 209657_s_at 0.000502 down HSF2 heat shock transcription factor 2 CDC16 cell division cycle 16 homolog 209659_s_at 0.000472 down CDC16 (S. cerevisiae) 209667_at 0.000886 down CES2 carboxylesterase 2 (intestine, liver) 209669_s_at 2.80E-05 down PAI-RBP1 PAI-1 mRNA-binding protein 209670_at 2.00E-06 down 209671_x_at 2.00E-06 down TRA@ T cell receptor alpha locus 209674_at 0.000114 down CRY1 cryptochrome 1 (photolyase-like) Cas-Br-M (murine) ecotropic retroviral 209682_at 0.000342 down CBLB transforming sequence b 209696_at 0.000429 down FBP1 fructose-1,6-bisphosphatase 1 209702_at 0.000486 down FTO fatso 209717_at 0.000709 down EVI5 ecotropic viral integration site 5 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 209732_at 1.70E-05 up CLECSF2 (activation-induced) 209761_s_at 0.000417 up SP110 SP110 nuclear body protein 209770_at 0.000183 down BTN3A1 butyrophilin, subfamily 3, member A1 CD24 antigen (small cell lung 209771_x_at 2.00E-06 up CD24 carcinoma cluster 4 antigen) 209774_x_at 8.00E-06 up CXCL2 chemokine (C-X-C motif) ligand 2 putative homeodomain transcription 209780_at 2.00E-06 down PHTF2 factor 2 high mobility group nucleosomal 209786_at 2.90E-05 down HMGN4 binding domain 4 high mobility group nucleosomal 209787_s_at 7.00E-06 down HMGN4 binding domain 4 type 1 tumor necrosis factor receptor 209788_s_at 8.40E-05 down ARTS-1 shedding aminopeptidase regulator 209791_at 1.30E-05 up PADI2 peptidyl arginine deiminase, type II 209796_s_at 2.70E-05 down TMEM4 transmembrane protein 4 209808_x_at 0.000782 down ING1 inhibitor of growth family, member 1 209813_x_at 2.00E-06 down 209815_at 7.00E-06 down major histocompatibility complex, class 209823_x_at 2.40E-05 down HLA-DQB1 II, DQ beta 1 interleukin 16 (lymphocyte 209827_s_at 9.00E-06 down IL16 chemoattractant factor) CD44 antigen (homing function and 209835_x_at 1.50E-05 up CD44 Indian blood group system) 209846_s_at 0.000339 down BTN3A2 butyrophilin, subfamily 3, member A2 209858_x_at 4.00E-06 down MPPE1 metallophosphoesterase 1 209861_s_at 5.90E-05 down METAP2 methionyl aminopeptidase 2 frequently rearranged in advanced T- 209864_at 0.000219 down FRAT2 cell lymphomas 2 RNA binding motif, single stranded 209868_s_at 2.00E-06 up RBMS1 interacting protein 1 secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early 209875_s_at 1.80E-05 up SPP1 T-lymphocyte activation 1) 209879_at 0.000914 down SELPLG selectin P ligand 209881_s_at 7.00E-06 down LAT linker for activation of T cells 209901_x_at 2.00E-06 down AIF1 allograft inflammatory factor 1 209911_x_at 0.000456 up HIST1H2BD histone 1, H2bd bone morphogenetic protein receptor, 209920_at 0.000517 up BMPR2 type II (serine/threonine kinase) nuclear factor (erythroid-derived 2), 209930_s_at 1.10E-05 up NFE2 45kDa 209933_s_at 1.30E-05 down CMRF-35H leukocyte membrane antigen CASP8 and FADD-like apoptosis 209939_x_at 0.000288 up CFLAR regulator hepatocyte growth factor (hepapoietin 209960_at 2.00E-06 up HGF A; scatter factor) spinocerebellar ataxia 7 (olivopontocerebellar atrophy with 209964_s_at 0.000955 up SCA7 retinal degeneration) 209967_s_at 1.30E-05 up CREM cAMP responsive element modulator caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, 209970_x_at 0.00097 up CASP1 convertase) BUB3 budding uninhibited by 209974_s_at 2.00E-06 down BUB3 benzimidazoles 3 homolog (yeast) 6-phosphofructo-2-kinase/fructose-2,6- 209992_at 2.00E-06 up PFKFB2 biphosphatase 2 mucosa associated lymphoid tissue 210017_at 2.00E-06 down MALT1 lymphoma translocation gene 1 mucosa associated lymphoid tissue 210018_x_at 0.000242 down MALT1 lymphoma translocation gene 1 APEX nuclease (multifunctional DNA 210027_s_at 2.00E-06 down APEX1 repair enzyme) 1 210029_at 0.000208 up INDO indoleamine-pyrrole 2,3 dioxygenase CD3Z antigen, zeta polypeptide (TiT3 210031_at 2.00E-06 down CD3Z complex) 210038_at 2.70E-05 down PRKCQ protein kinase C, theta isocitrate dehydrogenase 2 (NADP+), 210046_s_at 4.00E-06 down IDH2 mitochondrial 210054_at 0.000117 down MGC4701 chromosome 4 open reading frame 15 210101_x_at 4.00E-06 up SH3GLB1 SH3-domain GRB2-like endophilin B1 FYN oncogene related to SRC, FGR, 210105_s_at 2.00E-06 down FYN YES 210111_s_at 0.000643 down KIAA0265 KIAA0265 protein

SH2 domain protein 1A, Duncan's 210116_at 2.50E-05 down SH2D1A disease (lymphoproliferative syndrome) 210118_s_at 8.00E-06 up IL1A interleukin 1, alpha potassium inwardly-rectifying channel, 210119_at 6.80E-05 up KCNJ15 subfamily J, member 15 210125_s_at 8.00E-06 down BANF1 barrier to autointegration factor 1 210137_s_at 2.00E-06 down DCTD dCMP deaminase 210142_x_at 2.00E-06 up FLOT1 flotillin 1 homeodomain interacting protein 210148_at 0.000248 up HIPK3 kinase 3 ATP synthase, H+ transporting, 210149_s_at 0.00012 down ATP5H mitochondrial F0 complex, subunit d 210166_at 2.00E-06 up TLR5 toll-like receptor 5 protein tyrosine phosphatase, receptor 210173_at 0.000294 up PTPRJ type, J FUS interacting protein (serine-arginine 210178_x_at 3.30E-05 down FUSIP1 rich) 1 210190_at 2.00E-06 up STX11 syntaxin 11 putative homeodomain transcription 210191_s_at 2.10E-05 up PHTF1 factor 1 210218_s_at 0.00099 up SP100 nuclear antigen Sp100 210219_at 1.80E-05 up SP100 nuclear antigen Sp100 210220_at 0.00031 down FZD2 frizzled homolog 2 (Drosophila) 210222_s_at 0.000141 down RTN1 reticulon 1 major histocompatibility complex, class 210224_at 9.60E-05 up MR1 I-related SET translocation (myeloid leukemia- 210231_x_at 7.00E-05 down SET associated) 210244_at 2.00E-06 up CAMP cathelicidin antimicrobial peptide 210249_s_at 9.00E-05 down NCOA1 nuclear receptor coactivator 1 210250_x_at 2.00E-06 down ADSL adenylosuccinate lyase tumor necrosis factor, alpha-induced 210260_s_at 2.00E-06 down GG2-1 protein 8 potassium voltage-gated channel, 210263_at 0.000619 up KCNF1 subfamily F, member 1 210270_at 0.000193 up RGS6 regulator of G-protein signalling 6 210279_at 2.00E-06 down GPR18 G protein-coupled receptor 18 poly(A) binding protein interacting 210283_x_at 0.000237 down PAIP1 protein 1 granzyme H (cathepsin G-like 2, 210321_at 1.10E-05 down GZMH protein h-CCPX) 210337_s_at 3.80E-05 up ACLY ATP citrate lyase membrane-spanning 4-domains, 210356_x_at 0.000295 down MS4A1 subfamily A, member 1 210362_x_at 9.60E-05 up PML promyelocytic leukemia 210367_s_at 2.00E-04 up PTGES prostaglandin E synthase 210371_s_at 0.000254 down RBBP4 retinoblastoma binding protein 4 210425_x_at 4.00E-06 down GOLGIN-67 golgin-67 210426_x_at 1.00E-04 down RORA RAR-related orphan receptor A 210427_x_at 8.00E-06 down ANXA2 annexin A2 210449_x_at 2.00E-06 up MAPK14 mitogen-activated protein kinase 14 cytochrome P450, family 4, subfamily 210452_x_at 2.00E-06 up CYP4F2 F, polypeptide 2 210463_x_at 0.000136 down FLJ20244 hypothetical protein FLJ20244 210466_s_at 1.10E-05 down PAI-RBP1 PAI-1 mRNA-binding protein non-POU domain containing, octamer- 210470_x_at 4.90E-05 up NONO binding tumor necrosis factor receptor TNFRSF10 superfamily, member 10c, decoy 210484_s_at 0.000155 down C without an intracellular domain 210538_s_at 0.000492 down BIRC3 baculoviral IAP repeat-containing 3

210561_s_at 6.20E-05 up WSB1 WD repeat and SOCS box-containing 1 CASP8 and FADD-like apoptosis 210563_x_at 0.000299 up CFLAR regulator CASP8 and FADD-like apoptosis 210564_x_at 0.000257 up CFLAR regulator 210569_s_at 0.00046 up SIGLEC9 sialic acid binding Ig-like lectin 9 210582_s_at 8.40E-05 up LIMK2 LIM domain kinase 2 polymerase (DNA-directed), delta 210583_at 2.00E-06 up POLDIP3 interacting protein 3 glucosidase, beta; acid (includes 210589_s_at 0.000238 up GBA glucosylceramidase) killer cell lectin-like receptor subfamily 210606_x_at 2.40E-05 down KLRD1 D, member 1 210607_at 2.00E-06 down FLT3LG fms-related tyrosine kinase 3 ligand carcinoembryonic antigen-related cell adhesion molecule 1 (biliary 210610_at 2.00E-06 up CEACAM1 glycoprotein) tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E 210614_at 0.000518 up TTPA deficiency)

phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, 210617_at 9.60E-05 up PHEX vitamin D resistant rickets) cyclin-dependent kinase (CDC2-like) 210622_x_at 5.40E-05 down CDK10 10 210645_s_at 2.00E-06 down TTC3 tetratricopeptide repeat domain 3 210646_x_at 2.00E-06 down RPL13A ribosomal protein L13a 210648_x_at 2.00E-06 up SNX3 sorting nexin 3 210682_at 2.00E-06 up LPO lactoperoxidase 210705_s_at 0.000134 up TRIM5 tripartite motif-containing 5 210706_s_at 9.70E-05 up RNF24 ring finger protein 24

210715_s_at 4.70E-05 up SPINT2 serine protease inhibitor, Kunitz type, 2 210719_s_at 0.000242 down HMG20B high-mobility group 20B lectin, galactoside-binding, soluble, 8 210732_s_at 2.00E-06 up LGALS8 (galectin 8) 210740_s_at 1.30E-05 down ITPK1 inositol 1,3,4-triphosphate 5/6 kinase v-yes-1 Yamaguchi sarcoma viral 210754_s_at 6.70E-05 up LYN related oncogene homolog proteasome (prosome, macropain) 210759_s_at 0.000348 down PSMA1 subunit, alpha type, 1 CSE1 chromosome segregation 1-like 210766_s_at 0.000179 down CSE1L (yeast) 210772_at 4.20E-05 up FPRL1 formyl peptide receptor-like 1 210773_s_at 1.10E-05 up FPRL1 formyl peptide receptor-like 1 210778_s_at 0.000253 down MXD4 MAX dimerization protein 4 calcium/calmodulin-dependent protein 210787_s_at 1.90E-05 up CAMKK2 kinase kinase 2, beta 210797_s_at 0.000806 up OASL 2'-5'-oligoadenylate synthetase-like 210825_s_at 0.000675 down STOM stomatin 210829_s_at 8.00E-06 down SSBP2 single-stranded DNA binding protein 2 prostaglandin E receptor 3 (subtype 210832_x_at 0.000507 up PTGER3 EP3) 210843_s_at 0.00056 up KIAA0626 KIAA0626 gene product plasminogen activator, urokinase 210845_s_at 2.00E-06 up PLAUR receptor tumor necrosis factor receptor 210847_x_at 0.000129 down TNFRSF25 superfamily, member 25 210872_x_at 2.00E-06 up GAS7 growth arrest-specific 7 Fc fragment of IgG, low affinity IIb, 210889_s_at 0.000709 down FCGR2B receptor for (CD32) 210891_s_at 0.000203 down GTF2I general transcription factor II, i CD86 antigen (CD28 antigen ligand 2, 210895_s_at 2.00E-06 down CD86 B7-2 antigen) 210904_s_at 1.10E-05 up IL13RA1 interleukin 13 receptor, alpha 1 210908_s_at 2.00E-05 down PFDN5 prefoldin 5 210915_x_at 2.00E-06 down CD44 antigen (homing function and 210916_s_at 2.00E-06 up CD44 Indian blood group system) 210928_at 0.00043 up 210948_s_at 6.70E-05 up LEF1 lymphoid enhancer-binding factor 1 eukaryotic translation initiation factor 3, 210949_s_at 2.00E-06 down EIF3S8 subunit 8, 110kDa RAB27A, member RAS oncogene 210951_x_at 2.00E-06 up RAB27A family inhibitor of Bruton 210970_s_at 8.00E-06 down IBTK agammaglobulinemia tyrosine kinase 210972_x_at 2.00E-06 down 210978_s_at 1.30E-05 down TAGLN2 transgelin 2 210981_s_at 0.00027 down GRK6 G protein-coupled receptor kinase 6 major histocompatibility complex, class 210982_s_at 2.00E-06 down HLA-DRA II, DR alpha 210985_s_at 2.00E-06 up SP100 nuclear antigen Sp100 Fc fragment of IgG, low affinity IIa, 210992_x_at 9.60E-05 up FCGR2A receptor for (CD32) 211005_at 2.90E-05 down LAT linker for activation of T cells 211012_s_at 5.00E-06 up PML promyelocytic leukemia 211014_s_at 6.10E-05 up PML promyelocytic leukemia glucosaminyl (N-acetyl) transferase 2, I- 211020_at 8.10E-05 up GCNT2 branching enzyme 211038_s_at 2.50E-05 down MGC12760 hypothetical protein MGC12760 adaptor-related protein complex 2, 211047_x_at 1.10E-05 down AP2S1 sigma 1 subunit 211050_x_at 0.000258 up 211063_s_at 2.00E-05 down NCK1 NCK adaptor protein 1 211067_s_at 2.00E-06 up GAS7 growth arrest-specific 7 211073_x_at 2.00E-06 down RPL3 ribosomal protein L3 211087_x_at 2.00E-06 up MAPK14 mitogen-activated protein kinase 14 PRP4 pre-mRNA processing factor 4 211090_s_at 0.000756 up PRPF4B homolog B (yeast) Janus kinase 3 (a protein tyrosine 211108_s_at 2.00E-06 up JAK3 kinase, leukocyte) solute carrier family 5 (sodium iodide 211123_at 0.000482 up SLC5A5 symporter), member 5 211144_x_at 4.00E-06 down tumor necrosis factor receptor TNFRSF10 superfamily, member 10c, decoy 211163_s_at 0.000147 down C without an intracellular domain proprotein convertase subtilisin/kexin 211262_at 0.000806 up PACE4 type 6 211270_x_at 0.00011 down PTBP1 polypyrimidine tract binding protein 1 211271_x_at 8.90E-05 down PTBP1 polypyrimidine tract binding protein 1 211272_s_at 1.70E-05 up DGKA diacylglycerol kinase, alpha 80kDa 211275_s_at 2.00E-06 up GYG glycogenin tumor necrosis factor receptor 211282_x_at 1.10E-05 down TNFRSF25 superfamily, member 25 ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, 211285_s_at 3.00E-05 down UBE3A Angelman syndrome) 211296_x_at 6.00E-04 down UBC ubiquitin C 211299_s_at 3.00E-05 up FLOT2 flotillin 2 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce 211302_s_at 0.000192 up PDE4B homolog, Drosophila) 211305_x_at 4.00E-06 up FCAR Fc fragment of IgA, receptor for 211306_s_at 3.30E-05 up FCAR Fc fragment of IgA, receptor for 211307_s_at 2.00E-06 up FCAR Fc fragment of IgA, receptor for CASP8 and FADD-like apoptosis 211316_x_at 0.000156 down CFLAR regulator CASP8 and FADD-like apoptosis 211317_s_at 0.000903 up CFLAR regulator 211325_x_at 0.000428 down

trinucleotide repeat containing 11 (THR- 211342_x_at 2.00E-06 up TNRC11 associated protein, 230kDa subunit) eukaryotic translation elongation factor 211345_x_at 2.00E-06 down EEF1G 1 gamma 211356_x_at 0.000283 up LEPR leptin receptor caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, 211366_x_at 0.000624 up CASP1 convertase) 211372_s_at 2.00E-06 up IL1R2 interleukin 1 receptor, type II interleukin enhancer binding factor 3, 211375_s_at 3.10E-05 down ILF3 90kDa v-myc myelocytomatosis viral related oncogene, neuroblastoma derived 211377_x_at 0.000362 up MYCN (avian) 211378_x_at 2.00E-06 down 211390_at 0.000119 down CG018 hypothetical gene CG018 Fc fragment of IgG, low affinity IIb, 211395_x_at 1.10E-05 up FCGR2B receptor for (CD32) 211413_s_at 2.00E-06 up PADI4 peptidyl arginine deiminase, type IV 211416_x_at 0.000164 up GGT1 gamma-glutamyltransferase 1 sterol-C5-desaturase (ERG3 delta-5- 211423_s_at 2.00E-06 up SC5DL desaturase homolog, fungal)-like 211425_x_at 0.00099 up 211429_s_at 0.000119 up immunoglobulin heavy constant 211430_s_at 0.000189 down IGHG1 gamma 1 (G1m marker) 211487_x_at 2.00E-06 down eukaryotic translation initiation factor 3, 211501_s_at 8.00E-06 down EIF3S9 subunit 9 eta, 116kDa 211506_s_at 2.00E-06 up IL8 interleukin 8 pleckstrin homology, Sec7 and coiled- 211521_s_at 2.50E-05 up PSCD4 coil domains 4 211542_x_at 2.00E-06 down hydroxyprostaglandin dehydrogenase 211549_s_at 4.70E-05 up HPGD 15-(NAD) 211558_s_at 0.000189 down DHPS deoxyhypusine synthase 211561_x_at 2.00E-06 up MAPK14 mitogen-activated protein kinase 14 chondroitin sulfate proteoglycan 2 211571_s_at 2.00E-06 up CSPG2 (versican) 211588_s_at 0.000761 up PML promyelocytic leukemia 211597_s_at 1.00E-05 down HOP homeodomain-only protein protein tyrosine phosphatase, receptor 211600_at 0.00011 up PTPRO type, O 211610_at 0.00042 up COPEB core promoter element binding protein 211612_s_at 1.10E-05 up IL13RA1 interleukin 13 receptor, alpha 1 211622_s_at 2.00E-06 up ARF3 ADP-ribosylation factor 3 211623_s_at 2.00E-06 down FBL fibrillarin 211639_x_at 3.10E-05 up immunoglobulin heavy constant 211641_x_at 3.90E-05 down IGHG1 gamma 1 (G1m marker) 211644_x_at 6.90E-05 down major histocompatibility complex, class 211654_x_at 1.30E-05 down HLA-DQB1 II, DQ beta 1 major histocompatibility complex, class 211656_x_at 1.80E-05 down HLA-DQB1 II, DQ beta 1 211662_s_at 9.00E-06 down VDAC2 voltage-dependent anion channel 2 son of sevenless homolog 2 211665_s_at 2.00E-06 up SOS2 (Drosophila) 211666_x_at 2.00E-06 down RPL3 ribosomal protein L3 211668_s_at 1.90E-05 up PLAU plasminogen activator, urokinase 211675_s_at 2.00E-06 down HIC I-mfa domain-containing protein 211676_s_at 0.00026 up IFNGR1 interferon gamma receptor 1 211698_at 2.00E-06 down CRI1 CREBBP/EP300 inhibitor 1 211710_x_at 2.00E-06 down RPL4 ribosomal protein L4 OK/SW- 211714_x_at 5.00E-05 up CL.56 beta 5-tubulin 211720_x_at 2.00E-06 down RPLP0 ribosomal protein, large, P0 COX11 homolog, cytochrome c 211727_s_at 2.00E-06 down COX11 oxidase assembly protein (yeast) 211729_x_at 8.00E-06 down BLVRA biliverdin reductase A 211733_x_at 2.40E-05 down SCP2 sterol carrier protein 2 Fc fragment of IgE, high affinity I, 211734_s_at 0.000785 down FCER1A receptor for; alpha polypeptide proteasome (prosome, macropain) 211746_x_at 0.000366 down PSMA1 subunit, alpha type, 1 LSM5 homolog, U6 small nuclear RNA 211747_s_at 1.10E-05 down LSM5 associated (S. cerevisiae) 211750_x_at 0.000698 up TUBA6 tubulin alpha 6 NADH dehydrogenase (ubiquinone) Fe- S protein 7, 20kDa (NADH-coenzyme 211752_s_at 0.000256 down NDUFS7 Q reductase) ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, 211755_s_at 0.000114 down ATP5F1 isoform 1 211761_s_at 0.000234 down SIP Siah-interacting protein ubiquitin-conjugating enzyme E2D 1 211764_s_at 0.000982 up UBE2D1 (UBC4/5 homolog, yeast) peptidylprolyl isomerase A (cyclophilin 211765_x_at 4.00E-06 down PPIA A) 211783_s_at 1.70E-05 down MTA1 metastasis associated 1 eukaryotic translation initiation factor 211787_s_at 0.000123 down EIF4A1 4A, isoform 1 211794_at 1.20E-05 down FYB FYN binding protein (FYB-120/130) 211795_s_at 0.000181 down FYB FYN binding protein (FYB-120/130) 211796_s_at 2.00E-06 down potassium inwardly-rectifying channel, 211806_s_at 1.10E-05 up KCNJ15 subfamily J, member 15 CREB binding protein (Rubinstein- 211808_s_at 0.000115 up CREBBP Taybi syndrome) 211816_x_at 2.00E-06 up FCAR Fc fragment of IgA, receptor for myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 211826_s_at 1.30E-05 up MLL Drosophila) tumor necrosis factor receptor 211841_s_at 0.000217 down TNFRSF25 superfamily, member 25 carcinoembryonic antigen-related cell 211848_s_at 0.00099 up CEACAM7 adhesion molecule 7 CASP8 and FADD-like apoptosis 211862_x_at 8.90E-05 up CFLAR regulator 211872_s_at 6.80E-05 up RGS11 regulator of G-protein signalling 11 211876_x_at 0.000331 up PCDHGA11 protocadherin gamma subfamily A, 11 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary 211883_x_at 2.00E-06 up CEACAM1 glycoprotein) carcinoembryonic antigen-related cell adhesion molecule 1 (biliary 211889_x_at 2.00E-06 up CEACAM1 glycoprotein) 211902_x_at 2.00E-06 down 211919_s_at 0.00083 up CXCR4 chemokine (C-X-C motif) receptor 4 prothymosin, alpha (gene sequence 211921_x_at 2.00E-06 down PTMA 28) 211922_s_at 0.000683 up CAT catalase plasminogen activator, urokinase 211924_s_at 2.00E-06 up PLAUR receptor eukaryotic translation elongation factor 211927_x_at 2.00E-06 down EEF1G 1 gamma dynein, cytoplasmic, heavy polypeptide 211928_at 0.00026 down DNCH1 1 heterogeneous nuclear 211930_at 0.00037 down HNRNPA3 ribonucleoprotein A3 211934_x_at 1.00E-04 up G2AN glucosidase, alpha; neutral AB eukaryotic translation initiation factor 211937_at 2.00E-06 down EIF4B 4B eukaryotic translation initiation factor 211938_at 1.30E-05 down EIF4B 4B 211939_x_at 2.00E-06 down BTF3 basic transcription factor 3 211942_x_at 2.00E-06 down RPL13A ribosomal protein L13a integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 211945_s_at 2.00E-06 down ITGB1 includes MDF2, MSK12) 211950_at 0.000538 down RBAF600 retinoblastoma-associated factor 600 nucleolar and coiled-body 211951_at 0.00037 down NOLC1 phosphoprotein 1 211953_s_at 2.00E-06 down KPNB3 karyopherin (importin) beta 3 211954_s_at 2.00E-06 down KPNB3 karyopherin (importin) beta 3 insulin-like growth factor binding 211959_at 0.000345 up IGFBP5 protein 5 211970_x_at 0.000183 down ACTG1 actin, gamma 1 211971_s_at 2.00E-06 down LRPPRC leucine-rich PPR-motif containing 211972_x_at 2.00E-06 down RPLP0 ribosomal protein, large, P0 recombining binding protein 211974_x_at 4.00E-06 down RBPSUH suppressor of hairless (Drosophila) peptidylprolyl isomerase A (cyclophilin 211978_x_at 2.00E-06 down PPIA A) 211982_x_at 0.000735 down XPO6 exportin 6 calmodulin 1 (phosphorylase kinase, 211984_at 0.000317 down CALM1 delta) calmodulin 1 (phosphorylase kinase, 211985_s_at 0.000913 down CALM1 delta) 211986_at 2.00E-06 down MGC5395 hypothetical protein MGC5395 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, 211988_at 2.70E-05 down SMARCE1 subfamily e, member 1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, 211989_at 8.50E-05 down SMARCE1 subfamily e, member 1 major histocompatibility complex, class 211990_at 2.00E-06 down HLA-DPA1 II, DP alpha 1 major histocompatibility complex, class 211991_s_at 2.00E-06 down HLA-DPA1 II, DP alpha 1 DKFZP566C putative MAPK activating protein 212003_at 0.000911 up 0424 PM20,PM21 CD44 antigen (homing function and 212014_x_at 2.00E-06 up CD44 Indian blood group system) 212015_x_at 4.10E-05 down PTBP1 polypyrimidine tract binding protein 1 212016_s_at 3.80E-05 up PTBP1 polypyrimidine tract binding protein 1 DKFZP564 212018_s_at 2.00E-06 down M182 DKFZP564M182 protein 212032_s_at 0.000654 down PTOV1 prostate tumor overexpressed gene 1 212036_s_at 0.000112 down PNN pinin, desmosome associated protein 212038_s_at 4.00E-05 down VDAC1 voltage-dependent anion channel 1 212039_x_at 2.00E-06 down RPL3 ribosomal protein L3 212042_x_at 2.00E-06 down RPL7 ribosomal protein L7 212053_at 2.00E-06 down KIAA0251 KIAA0251 protein 212061_at 0.000307 down SR140 U2-associated SR140 protein 212062_at 2.00E-06 up ATP9A ATPase, Class II, type 9A CD44 antigen (homing function and 212063_at 2.80E-05 up CD44 Indian blood group system) 212074_at 1.10E-05 down UNC84A unc-84 homolog A (C. elegans) solute carrier family 25 (mitochondrial carrier; adenine nucleotide 212085_at 2.00E-06 down SLC25A6 translocator), member 6 glutamate receptor, ionotropic, N- methyl D-asparate-associated protein 1 212090_at 2.00E-06 up GRINA (glutamate binding) 212092_at 0.000117 up PEG10 paternally expressed 10 212098_at 9.00E-06 down LOC151162 hypothetical protein LOC151162 212114_at 2.30E-05 down 212118_at 0.000303 down RFP ret finger protein 212122_at 0.000555 down ARHQ ras homolog gene family, member Q 212138_at 0.000595 down KIAA0648 KIAA0648 protein 212144_at 2.00E-06 down UNC84B unc-84 homolog B (C. elegans) 212155_at 8.00E-06 down LOC149603 hypothetical protein LOC149603 exportin, tRNA (nuclear export receptor 212160_at 1.10E-05 down XPOT for tRNAs) 212169_at 0.000492 up FKBP9 FK506 binding protein 9, 63 kDa 212191_x_at 2.00E-06 down RPL13 ribosomal protein L13 transmembrane 9 superfamily protein 212194_s_at 0.000229 up TM9SF4 member 4 myosin phosphatase-Rho interacting 212197_x_at 0.000274 down M-RIP protein 212199_at 8.00E-06 down MGC9651 PP784 protein 212205_at 0.000845 down H2AV H2A histone family, member V putative L-type neutral amino acid 212217_at 3.20E-05 down KIAA0436 transporter iduronate 2-sulfatase (Hunter 212221_x_at 0.000127 down IDS syndrome) DKFZP434K 212228_s_at 0.000822 down 046 hypothetical protein DKFZp434K046 212231_at 0.000109 down FBXO21 F-box protein 21 212232_at 2.00E-06 down FNBP4 formin binding protein 4 phosphoinositide-3-kinase, regulatory 212239_at 0.000554 down PIK3R1 subunit, polypeptide 1 (p85 alpha) phosphoinositide-3-kinase, regulatory 212240_s_at 3.30E-05 down PIK3R1 subunit, polypeptide 1 (p85 alpha) glutamate receptor, ionotropic, N- 212244_at 9.60E-05 down GRINL1A methyl D-aspartate-like 1A

212245_at 0.000128 down MCFD2 multiple coagulation factor deficiency 2 212248_at 2.00E-06 down LYRIC LYRIC/3D3 phosphoinositide-3-kinase, regulatory 212249_at 5.80E-05 down PIK3R1 subunit, polypeptide 1 (p85 alpha) 212250_at 6.10E-05 down LYRIC LYRIC/3D3 calcium/calmodulin-dependent protein 212252_at 0.000595 up CAMKK2 kinase kinase 2, beta UDP-N-acetyl-alpha-D- galactosamine:polypeptide N- acetylgalactosaminyltransferase 10 212256_at 0.000985 down GALNT10 (GalNAc-T10) pre-B-cell leukemia transcription factor 212259_s_at 2.00E-06 down PBXIP1 interacting protein 1 212266_s_at 0.000199 down SFRS5 splicing factor, arginine/serine-rich 5 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 212268_at 2.10E-05 up SERPINB1 1 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated 212269_s_at 7.00E-05 down MCM3AP protein 212270_x_at 2.00E-06 down RPL17 ribosomal protein L17 212276_at 0.000315 down LPIN1 lipin 1 212287_at 0.000291 down JJAZ1 joined to JAZF1 212313_at 0.000194 down MGC29816 hypothetical protein MGC29816 212316_at 2.00E-06 down NUP210 nucleoporin 210 SREBP CLEAVAGE-ACTIVATING 212329_at 2.00E-06 down SCAP PROTEIN 212330_at 7.40E-05 up TFDP1 transcription factor Dp-1 glucosamine (N-acetyl)-6-sulfatase 212335_at 0.000169 up GNS (Sanfilippo disease IIID) amine oxidase (flavin containing) 212348_s_at 0.000806 down KIAA0601 domain 2 212352_s_at 9.00E-06 down TMP21 transmembrane trafficking protein adenosine monophosphate deaminase 212360_at 2.00E-06 down AMPD2 2 (isoform L) 212367_at 0.000234 down FEM1B fem-1 homolog b (C. elegans) 212371_at 3.30E-05 down PNAS-4 CGI-146 protein 212375_at 8.00E-06 down EP400 E1A binding protein p400

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole 212378_at 0.000902 down GART synthetase 212388_at 6.70E-05 down USP24 ubiquitin specific protease 24 212391_x_at 2.00E-06 down RPS3A ribosomal protein S3A 212400_at 2.00E-06 down chromosome 20 open reading frame 212406_s_at 2.00E-06 down C20ORF36 36 212414_s_at 2.00E-06 down 6-Sep septin 6 212415_at 4.70E-05 down 6-Sep septin 6 212416_at 9.20E-05 down SCAMP1 secretory carrier membrane protein 1

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 212426_s_at 2.80E-05 down YWHAQ theta polypeptide RNA-binding region (RNP1, RRM) 212430_at 0.000466 down RNPC1 containing 1 212433_x_at 2.00E-06 down RPS2 ribosomal protein S2 putative nucleic acid binding protein 212438_at 0.000386 up RY1 RY-1 heterogeneous nuclear 212454_x_at 2.00E-06 down HNRPDL ribonucleoprotein D-like sprouty-related, EVH1 domain 212458_at 0.000622 up SPRED2 containing 2 succinate-CoA ligase, GDP-forming, 212459_x_at 2.00E-06 down SUCLG2 beta subunit ornithine decarboxylase antizyme 212461_at 2.00E-06 up OAZIN inhibitor MYST histone acetyltransferase 212462_at 2.00E-06 down MYST4 (monocytic leukemia) 4 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 212463_at 2.00E-06 up CD59 16.3A5, EJ16, EJ30, EL32 and G344) 212473_s_at 4.00E-06 down MICAL2 flavoprotein oxidoreductase MICAL2 FYN oncogene related to SRC, FGR, 212486_s_at 4.00E-06 down FYN YES 212496_s_at 0.000301 down JMJD2B jumonji domain containing 2B 212508_at 0.00035 down MOAP1 modulator of apoptosis 1 212522_at 0.000697 down PDE8A phosphodiesterase 8A MADS box transcription enhancer factor 2, polypeptide A (myocyte 212535_at 0.000206 up MEF2A enhancer factor 2A) 212537_x_at 2.00E-06 down RPL17 ribosomal protein L17 212544_at 8.00E-06 down TRIP3 thyroid hormone receptor interactor 3 212547_at 7.30E-05 down signal transducer and activator of 212550_at 8.90E-05 up STAT5B transcription 5B 212557_at 0.000499 down ZNF451 zinc finger protein 451 212566_at 0.000222 down MAP4 microtubule-associated protein 4 212578_x_at 2.00E-06 down RPS17 ribosomal protein S17 212586_at 0.000241 down CAST calpastatin 212591_at 0.000129 down KIAA0117 KIAA0117 protein immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and 212592_at 0.00061 down IGJ mu polypeptides programmed cell death 4 (neoplastic 212593_s_at 0.000146 down PDCD4 transformation inhibitor) programmed cell death 4 (neoplastic 212594_at 0.000299 down PDCD4 transformation inhibitor) WD repeat and FYVE domain 212598_at 2.00E-06 up WDFY3 containing 3 212599_at 0.000251 down AUTS2 autism susceptibility candidate 2 ubiquinol-cytochrome c reductase core 212600_s_at 0.000245 down UQCRC2 protein II WD repeat and FYVE domain 212602_at 2.00E-06 up WDFY3 containing 3 212605_s_at 6.80E-05 down WD repeat and FYVE domain 212606_at 6.80E-05 up WDFY3 containing 3 212608_s_at 8.00E-06 down 212613_at 4.30E-05 down BTN3A3 butyrophilin, subfamily 3, member A3 chromodomain helicase DNA binding 212615_at 8.40E-05 down FLJ12178 protein 9 chromodomain helicase DNA binding 212616_at 0.000455 down FLJ12178 protein 9 212625_at 0.000225 down STX10 syntaxin 10 212633_at 0.000321 down KIAA0776 KIAA0776 212637_s_at 0.000783 down WWP1 WW domain-containing protein 1 212638_s_at 5.80E-05 down WWP1 WW domain-containing protein 1 212639_x_at 2.80E-05 up K-ALPHA-1 tubulin, alpha, ubiquitous human immunodeficiency virus type I 212641_at 8.60E-05 up HIVEP2 enhancer binding protein 2 212646_at 2.00E-06 down RAFTLIN raft-linking protein related RAS viral (r-ras) oncogene 212647_at 0.000256 down RRAS homolog 212652_s_at 0.000541 down SNX4 sorting nexin 4 212657_s_at 2.00E-06 up IL1RN interleukin 1 receptor antagonist 212658_at 0.000259 up LHFPL2 lipoma HMGIC fusion partner-like 2 212659_s_at 2.00E-06 up IL1RN interleukin 1 receptor antagonist 212660_at 0.000226 down PHF15 PHD finger protein 15 peptidylprolyl isomerase A (cyclophilin 212661_x_at 2.00E-06 down PPIA A) 212664_at 0.000108 up TUBB5 tubulin, beta, 5 major histocompatibility complex, class 212671_s_at 2.00E-06 down HLA-DQA1 II, DQ alpha 1 212673_at 1.10E-05 down METAP1 methionyl aminopeptidase 1 erythrocyte membrane protein band 212681_at 9.60E-05 down EPB41L3 4.1-like 3 212683_at 8.90E-05 up KIAA0446 KIAA0446 gene product 212689_s_at 1.80E-05 down JMJD1 jumonji domain containing 1A 212690_at 4.00E-06 down KIAA0725 DDHD domain containing 2 212696_s_at 9.80E-05 down RNF4 ring finger protein 4 212705_x_at 0.000915 up TTS-2.2 transport-secretion protein 2.2 212706_at 2.00E-06 down RASA4 RAS p21 protein activator 4 212709_at 0.000486 down NUP160 nucleoporin 160kDa 212713_at 0.000262 up MFAP4 microfibrillar-associated protein 4 eukaryotic translation initiation factor 3 212716_s_at 1.10E-05 down EIF3K subunit k 212734_x_at 2.00E-06 down RPL13 ribosomal protein L13 chromosome 6 open reading frame 212756_s_at 0.000474 down C6ORF133 133 calcium/calmodulin-dependent protein 212757_s_at 3.20E-05 down CAMK2G kinase (CaM kinase) II gamma differentially expressed in 212768_s_at 0.000104 up GW112 hematopoietic lineages transducin-like enhancer of split 3 212769_at 0.000324 up TLE3 (E(sp1) homolog, Drosophila) translocase of outer mitochondrial 212773_s_at 2.00E-06 down TOMM20 membrane 20 homolog (yeast) 212790_x_at 2.00E-06 down RPL13A ribosomal protein L13a 212791_at 0.000434 down FLJ38984 hypothetical protein FLJ38984 212797_at 0.000242 up SORT1 sortilin 1 212805_at 2.80E-05 up KIAA0367 KIAA0367 212807_s_at 3.00E-05 up SORT1 sortilin 1 212812_at 0.000265 down 212815_at 0.000497 down HELIC1 helicase, ATP binding 1 212823_s_at 2.20E-05 down KIAA0599 KIAA0599 solute carrier family 25 (mitochondrial carrier; adenine nucleotide 212826_s_at 2.00E-06 down SLC25A6 translocator), member 6 212827_at 0.000236 down IGHM immunoglobulin heavy constant mu 212829_at 0.000217 down 212833_at 0.000806 down LOC91137 hypothetical protein BC017169 GRIP and coiled-coil domain 212842_x_at 0.000312 down GCC2 containing 2 212849_at 0.000215 down AXIN1 axin 1 zinc finger, DHHC domain containing 212860_at 3.40E-05 up ZDHHC18 18 CDP-diacylglycerol synthase 212862_at 4.20E-05 up CDS2 (phosphatidate cytidylyltransferase) 2 212863_x_at 0.000455 down CTBP1 C-terminal binding protein 1 CDP-diacylglycerol synthase 212864_at 0.000356 down CDS2 (phosphatidate cytidylyltransferase) 2 Ras association (RalGDS/AF-6) 212870_at 3.00E-05 up RASSF3 domain family 3 MPHOSPH1 M-phase phosphoprotein 10 (U3 small 212885_at 5.70E-05 down 0 nucleolar ribonucleoprotein) 212888_at 0.000989 down DICER1 Dicer1, Dcr-1 homolog (Drosophila) 212893_at 0.000115 down ZZZ3 zinc finger, ZZ domain containing 3 212904_at 1.10E-05 down KIAA1185 KIAA1185 protein 212910_at 2.00E-06 down THAP11 THAP domain containing 11 212914_at 9.80E-05 down CBX7 chromobox homolog 7 212918_at 2.10E-05 down FLJ22028 hypothetical protein FLJ22028 SMC5 structural maintenance of 212927_at 0.000216 down SMC5L1 chromosomes 5-like 1 (yeast) ATPase, Ca++ transporting, plasma 212930_at 0.000594 down ATP2B1 membrane 1 212933_x_at 2.00E-06 down RPL13 ribosomal protein L13 212944_at 0.000176 down MRPS6 mitochondrial ribosomal protein S6 solute carrier family 9 (sodium/hydrogen exchanger), isoform 212947_at 0.000283 up SLC9A8 8 212953_x_at 0.00054 down CALR calreticulin polymerase (RNA) II (DNA directed) 212955_s_at 2.50E-05 down POLR2I polypeptide I, 14.5kDa 212956_at 2.00E-06 down KIAA0882 KIAA0882 protein 212959_s_at 0.000841 down MGC4170 MGC4170 protein 212961_x_at 1.10E-05 down LOC91966 hypothetical protein LOC91966 212967_x_at 2.00E-06 down NAP1L1 nucleosome assembly protein 1-like 1 212995_x_at 2.00E-06 down FLJ14346 hypothetical protein FLJ14346 major histocompatibility complex, class 212998_x_at 0.000115 down HLA-DQB1 II, DQ beta 1 myristoylated alanine-rich protein 213002_at 1.10E-05 up MARCKS kinase C substrate 213018_at 2.00E-06 down ODAG ocular development-associated gene 213025_at 3.40E-05 down FLJ20274 THUMP domain containing 1

213036_x_at 9.00E-06 down ATP2A3 ATPase, Ca++ transporting, ubiquitous rho/rac guanine nucleotide exchange 213039_at 2.00E-06 down ARHGEF18 factor (GEF) 18 ATP synthase, H+ transporting, mitochondrial F1 complex, delta 213041_s_at 1.20E-05 down ATP5D subunit

213042_s_at 0.000793 up ATP2A3 ATPase, Ca++ transporting, ubiquitous thyroid hormone receptor associated 213043_s_at 3.40E-05 down THRAP4 protein 4 SET translocation (myeloid leukemia- 213047_x_at 2.00E-06 down SET associated) SET translocation (myeloid leukemia- 213048_s_at 2.00E-06 down SET associated) 213056_at 7.90E-05 up GRSP1 GRP1-binding protein GRSP1 213064_at 4.00E-06 down FLJ11806 nuclear protein UKp68 phosphoinositide-3-kinase, class 2, 213070_at 0.000103 down PIK3C2A alpha polypeptide 213080_x_at 2.00E-06 down RPL5 ribosomal protein L5 213083_at 2.00E-06 down SLC35D2 solute carrier family 35, member D2 213084_x_at 2.00E-06 down RPL23A ribosomal protein L23a DnaJ (Hsp40) homolog, subfamily C, 213088_s_at 4.00E-05 down DNAJC9 member 9 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated 213090_s_at 9.00E-06 down TAF4 factor, 135kDa 213095_x_at 2.00E-06 down AIF1 allograft inflammatory factor 1 ATPase, aminophospholipid transporter (APLT), Class I, type 8A, 213106_at 4.90E-05 down ATP8A1 member 1 glycine cleavage system protein H 213129_s_at 0.000626 down GCSH (aminomethyl carrier) T-cell lymphoma invasion and 213135_at 2.00E-06 down TIAM1 metastasis 1 protein tyrosine phosphatase, non- 213137_s_at 1.80E-05 up PTPN2 receptor type 2 AT rich interactive domain 5A (MRF1- 213138_at 0.000553 up ARID5A like) Splicing factor, arginine/serine-rich, 213152_s_at 0.000167 down SRP46 46kD 213159_at 2.00E-06 up PCNX pecanex homolog (Drosophila) solute carrier family 5 (inositol 213164_at 0.000481 down SLC5A3 transporters), member 3 213166_x_at 7.00E-06 down FLJ14346 hypothetical protein FLJ14346 213173_at 8.00E-06 up PCNX pecanex homolog (Drosophila) cyclin-dependent kinase inhibitor 1C 213182_x_at 2.00E-06 down CDKN1C (p57, Kip2) 213193_x_at 2.00E-06 down 213232_at 0.000313 up KIAA1467 KIAA1467 protein 213238_at 0.000501 down ATP10D ATPase, Class V, type 10D 213242_x_at 6.30E-05 up KIAA0284 KIAA0284 213256_at 0.000958 up MGC48332 hypothetical protein MGC48332 213274_s_at 0.000454 up CTSB cathepsin B 213293_s_at 0.00068 up TRIM22 tripartite motif-containing 22 213294_at 0.000852 up FLJ38348 hypothetical protein FLJ38348 213301_x_at 0.000248 down TIF1 transcriptional intermediary factor 1 213313_at 0.000205 down GPR21 G protein-coupled receptor 21 213315_x_at 0.000111 down LOC91966 hypothetical protein LOC91966 vesicle-associated membrane protein 1 213326_at 0.000224 down VAMP1 (synaptobrevin 1) 213341_at 1.10E-05 up FEM1C fem-1 homolog c (C.elegans) 213347_x_at 2.00E-06 down RPS4X ribosomal protein S4, X-linked cyclin-dependent kinase inhibitor 1C 213348_at 8.00E-06 down CDKN1C (p57, Kip2) heterogeneous nuclear 213356_x_at 2.00E-06 down HNRPA1 ribonucleoprotein A1 213360_s_at 1.80E-05 down ATP synthase, H+ transporting, mitochondrial F1 complex, gamma 213366_x_at 1.70E-05 down ATP5C1 polypeptide 1 caspase 8, apoptosis-related cysteine 213373_s_at 1.00E-04 down CASP8 protease zinc finger and BTB domain containing 213376_at 2.50E-05 down ZBTB1 1 213377_x_at 2.00E-06 down RPS12 ribosomal protein S12 213385_at 0.000672 down CHN2 chimerin (chimaerin) 2

megalencephalic leukoencephalopathy 213395_at 0.000755 down MLC1 with subcortical cysts 1 chromosome 14 open reading frame 213398_s_at 0.000387 down HCDI 124 213399_x_at 0.000142 down RPN2 ribophorin II 213402_at 0.000232 up LOC126208 hypothetical protein LOC126208

213406_at 1.30E-05 up WSB1 WD repeat and SOCS box-containing 1 chromosome 10 open reading frame 213410_at 0.000158 down EDRF1 137 213414_s_at 2.00E-06 down RPS19 ribosomal protein S19 integrin, alpha 4 (antigen CD49D, 213416_at 2.00E-06 down ITGA4 alpha 4 subunit of VLA-4 receptor) 213417_at 0.000801 up TBX2 T-box 2 zinc finger CCCH type domain 213445_at 2.00E-06 up ZC3HDC3 containing 3 Williams Beuren syndrome 213460_x_at 0.000308 down WBSCR20C chromosome region 20C cleavage and polyadenylation specific 213461_at 9.60E-05 down CPSF5 factor 5, 25 kDa

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated 213475_s_at 2.00E-06 down ITGAL antigen 1; alpha polypeptide) eukaryotic translation elongation factor 213477_x_at 1.50E-05 down EEF1A1 1 alpha 1 ATP-binding cassette, sub-family C 213485_s_at 0.000131 down ABCC10 (CFTR/MRP), member 10 213491_x_at 4.20E-05 down RPN2 ribophorin II 213499_at 0.00076 up CLCN2 chloride channel 2 213503_x_at 8.00E-06 down ANXA2 annexin A2 213505_s_at 0.000125 down SFRS14 splicing factor, arginine/serine-rich 14 coagulation factor II (thrombin) 213506_at 2.00E-06 down F2RL1 receptor-like 1 putative lymphocyte G0/G1 switch 213524_s_at 2.00E-06 up G0S2 gene similar to hypothetical protein 213527_s_at 0.000192 down LOC146542 MGC13138 213528_at 0.000457 down MGC9084 hypothetical protein MGC9084 CD3D antigen, delta polypeptide (TiT3 213539_at 2.00E-06 down CD3D complex) inhibitor of growth family, member 1- 213544_at 3.20E-05 down ING1L like 213545_x_at 2.00E-06 up SNX3 sorting nexin 3 DKFZP586I 213546_at 0.000229 down 1420 hypothetical protein DKFZp586I1420 213564_x_at 2.00E-06 down LDHB lactate dehydrogenase B 213566_at 6.80E-05 down RNASE6 ribonuclease, RNase A family, k6 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 213572_s_at 1.70E-05 up SERPINB1 1 213581_at 1.00E-05 down PDCD2 programmed cell death 2 213582_at 0.000218 up ATP11A ATPase, Class VI, type 11A eukaryotic translation elongation factor 213583_x_at 2.00E-06 down EEF1A1 1 alpha 1 213587_s_at 0.000672 down C7ORF32 chromosome 7 open reading frame 32 213588_x_at 2.00E-06 down RPL14 ribosomal protein L14 eukaryotic translation elongation factor 213614_x_at 1.00E-05 down EEF1A1 1 alpha 1 heterogeneous nuclear 213619_at 9.00E-06 down HNRPH1 ribonucleoprotein H1 (H) 213620_s_at 1.80E-05 down ICAM2 intercellular adhesion molecule 2 213622_at 8.20E-05 up COL9A2 collagen, type IX, alpha 2 213626_at 8.00E-06 down FLJ14431 hypothetical protein FLJ14431 213627_at 0.000115 down MAGED2 melanoma antigen, family D, 2 tRNA (5-methylaminomethyl-2- 213634_s_at 0.000154 down FLJ10140 thiouridylate)-methyltransferase 1 213638_at 0.000333 up RPEL1 phosphatase and actin regulator 1 213646_x_at 0.000235 up K-ALPHA-1 tubulin, alpha, ubiquitous splicing factor, arginine/serine-rich 7, 213649_at 8.00E-06 down SFRS7 35kDa 213653_at 0.000243 down METTL3 methyltransferase like 3 213666_at 0.000279 down 6-Sep septin 6 213669_at 1.10E-05 down FCHO1 FCH domain only 1 213687_s_at 2.00E-06 down RPL35A ribosomal protein L35a 213694_at 0.000103 down FLJ11220 hypothetical protein FLJ11220 213698_at 4.00E-06 down ZNF258 zinc finger protein 258

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 213699_s_at 2.00E-06 down YWHAQ theta polypeptide 213716_s_at 0.000492 down SECTM1 secreted and transmembrane 1 213725_x_at 0.000316 down LOC283824 hypothetical protein LOC283824 213727_x_at 2.00E-06 down MPPE1 metallophosphoesterase 1 213729_at 0.000394 down FNBP3 formin binding protein 3 DKFZP434P 213737_x_at 2.00E-06 down 162 hypothetical protein DKFZp434P162 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha 213738_s_at 2.00E-06 down ATP5A1 subunit, isoform 1, cardiac muscle 213742_at 0.000755 down SFRS11 splicing factor, arginine/serine-rich 11 213750_at 0.000117 down 213754_s_at 0.000692 down TRIM26 tripartite motif-containing 26 213761_at 0.000237 down MDM1 nuclear protein double minute 1 213762_x_at 1.70E-05 down RBMX RNA binding motif protein, X-linked emopamil binding protein (sterol 213787_s_at 8.70E-05 down EBP isomerase) chromosome 14 open reading frame 213794_s_at 1.10E-05 down C14ORF120 120 laminin receptor 1 (ribosomal protein 213801_x_at 2.00E-06 down LAMR1 SA, 67kDa) inositol polyphosphate-5-phosphatase, 213804_at 0.000316 down INPP5B 75kDa chromosome 6 open reading frame 213810_s_at 0.000936 up C6ORF166 166 213817_at 2.40E-05 up 213839_at 0.000883 down KIAA0500 KIAA0500 protein 213846_at 2.00E-06 down COX7C cytochrome c oxidase subunit VIIc 213848_at 9.00E-06 down DUSP7 dual specificity phosphatase 7 213864_s_at 2.00E-06 down NAP1L1 nucleosome assembly protein 1-like 1 SMT3 suppressor of mif two 3 homolog 213881_x_at 0.000356 down SMT3H2 2 (yeast) polymerase (RNA) II (DNA directed) 213887_s_at 5.00E-05 down POLR2E polypeptide E, 25kDa TRAF3-interacting Jun N-terminal 213888_s_at 0.000707 down T3JAM kinase (JNK)-activating modulator 213890_x_at 2.00E-06 down RPS16 ribosomal protein S16 213892_s_at 2.00E-06 down APRT adenine phosphoribosyltransferase v-myb myeloblastosis viral oncogene 213906_at 2.00E-06 down MYBL1 homolog (avian)-like 1 213915_at 1.30E-05 down NKG7 natural killer cell group 7 sequence 213926_s_at 1.90E-05 up HRB HIV-1 Rev binding protein 213941_x_at 2.00E-06 down RPS7 ribosomal protein S7 213942_at 0.000143 down EGFL3 EGF-like-domain, multiple 3 213958_at 2.00E-05 down CD6 CD6 antigen 213969_x_at 2.00E-06 down RPL29 ribosomal protein L29 213979_s_at 0.000327 down CTBP1 C-terminal binding protein 1 213980_s_at 0.000118 down CTBP1 C-terminal binding protein 1 213986_s_at 0.000285 up C19ORF6 chromosome 19 open reading frame 6 214003_x_at 2.00E-06 down RPS20 ribosomal protein S20 214007_s_at 0.000694 up PTK9 PTK9 protein tyrosine kinase 9 interferon induced transmembrane 214022_s_at 0.00029 up IFITM1 protein 1 (9-27) sprouty-related, EVH1 domain 214026_s_at 0.000295 up SPRED2 containing 2 zeta-chain (TCR) associated protein 214032_at 7.00E-06 down ZAP70 kinase 70kDa 214041_x_at 0.00071 down RPL37A ribosomal protein L37a 214042_s_at 2.00E-06 down 214049_x_at 2.00E-06 down CD7 CD7 antigen (p41) 214054_at 2.10E-05 down DOK2 docking protein 2, 56kDa 214061_at 0.000182 down MGC21654 unknown MGC21654 product neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, 214084_x_at 1.10E-05 up NCF1 autosomal 1) 214085_x_at 0.000935 down GLIPR1 GLI pathogenesis-related 1 (glioma) 214092_x_at 0.00021 down SFRS14 splicing factor, arginine/serine-rich 14 phosphodiesterase 4D interacting 214099_s_at 5.10E-05 up PDE4DIP protein (myomegalin) splicing factor, arginine/serine-rich 7, 214141_x_at 2.00E-06 down SFRS7 35kDa 214143_x_at 2.00E-06 down RPL24 ribosomal protein L24 214167_s_at 2.00E-06 down RPLP0 ribosomal protein, large, P0 214170_x_at 2.00E-05 down FH fumarate hydratase 214173_x_at 2.00E-06 down C19ORF2 chromosome 19 open reading frame 2 214186_s_at 0.000342 down complement component 1, q 214214_s_at 1.30E-05 down C1QBP subcomponent binding protein mitogen-activated protein kinase 214219_x_at 1.30E-05 down MAP4K1 kinase kinase kinase 1 214246_x_at 3.80E-05 down MINK misshapen/NIK-related kinase 214271_x_at 2.00E-06 down RPL12 ribosomal protein L12 heterogeneous nuclear 214280_x_at 2.00E-06 down HNRPA1 ribonucleoprotein A1 ring finger and CHY zinc finger domain 214281_s_at 0.000437 up ZNF363 containing 1 214290_s_at 4.00E-06 up HIST2H2AA histone 2, H2aa 214298_x_at 2.00E-06 down 6-Sep septin 6 eukaryotic translation initiation factor 214314_s_at 4.00E-06 down EIF5B 5B 214317_x_at 1.90E-05 down RPS9 ribosomal protein S9 214321_at 2.00E-06 down NOV nephroblastoma overexpressed gene UPF3 regulator of nonsense transcripts 214323_s_at 2.00E-06 down UPF3A homolog A (yeast) 214351_x_at 2.00E-06 down RPL13 ribosomal protein L13 214363_s_at 3.30E-05 down MATR3 matrin 3 214366_s_at 1.30E-05 up ALOX5 arachidonate 5-lipoxygenase RAS guanyl releasing protein 2 214368_at 0.000585 down RASGRP2 (calcium and DAG-regulated) 214377_s_at 0.000282 up CTRL chymotrypsin-like 214383_x_at 8.50E-05 down KLHDC3 kelch domain containing 3 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange 214394_x_at 2.00E-06 down EEF1D protein) 214431_at 6.80E-05 down GMPS guanine monphosphate synthetase serine hydroxymethyltransferase 2 214437_s_at 1.70E-05 down SHMT2 (mitochondrial) 214438_at 0.000383 up HLX1 H2.0-like homeo box 1 (Drosophila) 214439_x_at 0.000394 down BIN1 bridging integrator 1 214450_at 7.50E-05 down CTSW cathepsin W (lymphopain) a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin 214454_at 0.000484 up ADAMTS2 type 1 motif, 2 214455_at 0.000113 up HIST1H2BC histone 1, H2bc 214465_at 2.00E-06 up ORM1 orosomucoid 1 killer cell lectin-like receptor subfamily 214470_at 2.00E-06 down KLRB1 B, member 1 214472_at 0.00015 up HIST1H3D histone 1, H3d CASP8 and FADD-like apoptosis 214486_x_at 6.90E-05 up CFLAR regulator Fc fragment of IgG, high affinity Ia, 214511_x_at 9.00E-06 up FCGR1A receptor for (CD64) 214522_x_at 0.000142 up HIST1H3D histone 1, H3d quaking homolog, KH domain RNA 214543_x_at 0.000736 up QKI binding (mouse) 214551_s_at 2.00E-06 down CD7 CD7 antigen (p41) leukocyte immunoglobulin-like receptor, subfamily A (without TM 214561_at 5.50E-05 up ILT10 domain), member 5 214567_s_at 0.000193 down XCL1 chemokine (C motif) ligand 1

214579_at 6.80E-05 up DJ462O23.2 hypothetical protein dJ462O23.2 214591_at 0.000989 up KLHL4 kelch-like 4 (Drosophila) purinergic receptor P2Y, G-protein 214615_at 0.000781 down P2RY10 coupled, 10 214617_at 4.00E-06 down PRF1 perforin 1 (pore forming protein) CASP8 and FADD-like apoptosis 214618_at 0.000116 up CFLAR regulator 214637_at 2.00E-06 up OSM oncostatin M 214662_at 0.00085 down KIAA0007 KIAA0007 protein 214667_s_at 0.000577 up TP53I11 tumor protein p53 inducible protein 11 214669_x_at 5.50E-05 down 214677_x_at 0.000113 down IGLJ3 immunoglobulin lambda joining 3 214681_at 0.000256 up GK glycerol kinase MADS box transcription enhancer factor 2, polypeptide A (myocyte 214684_at 0.000757 up MEF2A enhancer factor 2A) 214685_at 0.00099 up C4ORF10 chromosome 4 open reading frame 10 214686_at 4.00E-06 down ZNF266 zinc finger protein 266 214709_s_at 3.70E-05 down KTN1 kinectin 1 (kinesin receptor) 214718_at 0.00016 down ODAG ocular development-associated gene 214719_at 0.00075 down LOC283537 hypothetical protein LOC283537 214720_x_at 7.00E-04 up 10-Sep septin 10 214732_at 0.000556 up SP1 Sp1 transcription factor 214733_s_at 0.000266 up DJ167A19.1 hypothetical protein DJ167A19.1 cut-like 1, CCAAT displacement protein 214743_at 2.00E-06 down CUTL1 (Drosophila) 214748_at 0.000703 up LOC88523 CG016 214749_s_at 0.000312 down FLJ20811 hypothetical protein FLJ20811 ATPase, H+ transporting, lysosomal 214762_at 2.40E-05 up ATP6V1G2 13kDa, V1 subunit G isoform 2 N-acylsphingosine amidohydrolase 214765_s_at 2.00E-06 down ASAHL (acid ceramidase)-like Splicing factor, arginine/serine-rich, 214789_x_at 2.00E-05 down SRP46 46kD 214798_at 0.000654 up KIAA0703 KIAA0703 gene product 214800_x_at 2.00E-06 down BTF3 basic transcription factor 3 succinate-CoA ligase, GDP-forming, 214835_s_at 2.00E-06 down SUCLG2 beta subunit 214836_x_at 6.30E-05 down plasminogen activator, urokinase 214866_at 2.00E-06 up PLAUR receptor 214882_s_at 0.000504 down SFRS2 splicing factor, arginine/serine-rich 2 thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) 214883_at 0.000297 up THRA oncogene homolog, avian) dimethylarginine 214909_s_at 3.30E-05 up DDAH2 dimethylaminohydrolase 2 214938_x_at 0.000323 down HMGB1 high-mobility group box 1 214949_at 0.000274 down glutamate receptor, ionotropic, kainate 214966_at 0.000361 up GRIK5 5 215009_s_at 0.000528 down SEC31L1 SEC31-like 1 (S. cerevisiae) 215031_x_at 0.000164 down RNF126 ring finger protein 126 215043_s_at 0.000345 down LOC153561 hypothetical protein LOC153561 215049_x_at 2.00E-06 down CD163 CD163 antigen mitogen-activated protein kinase- 215050_x_at 0.000669 up MAPKAPK2 activated protein kinase 2 215051_x_at 2.00E-06 down AIF1 allograft inflammatory factor 1

215078_at 1.50E-05 up SOD2 superoxide dismutase 2, mitochondrial 215091_s_at 2.00E-06 down GTF3A general transcription factor IIIA

215096_s_at 4.60E-05 down ESD esterase D/formylglutathione hydrolase neurotrophic tyrosine kinase, receptor, 215115_x_at 0.000343 up NTRK3 type 3 215121_x_at 0.00014 down RNA binding motif, single stranded 215127_s_at 8.00E-06 up RBMS1 interacting protein 1 215136_s_at 2.80E-05 down OIP2 exosome component 8 215147_at 0.000968 down 215157_x_at 8.00E-06 down PABPC3 poly(A) binding protein, cytoplasmic 3 215160_x_at 0.000298 down FRG1 FSHD region gene 1 215176_x_at 0.00021 down 215177_s_at 0.000276 up ITGA6 integrin, alpha 6 major histocompatibility complex, class 215193_x_at 8.00E-06 down HLA-DRB3 II, DR beta 3

215223_s_at 2.00E-06 up SOD2 superoxide dismutase 2, mitochondrial 215227_x_at 2.00E-06 down ACP1 acid phosphatase 1, soluble eukaryotic translation initiation factor 3, 215230_x_at 2.00E-06 down EIF3S8 subunit 8, 110kDa sulfotransferase family, cytosolic, 1A, 215299_x_at 7.00E-06 down SULT1A1 phenol-preferring, member 1 215315_at 3.40E-05 up FLJ34917 zinc finger protein 549 215370_at 2.90E-05 down 215379_x_at 6.60E-05 down IGLJ3 immunoglobulin lambda joining 3 215440_s_at 2.00E-06 down FLJ10097 brain expressed X-linked-like 1 small nuclear ribonucleoprotein 215450_at 0.00045 down SNRPE polypeptide E myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 215451_s_at 0.000152 up MLLT2 Drosophila); translocated to, 2 215462_at 0.000387 up 215492_x_at 0.00053 up PTCRA pre T-cell antigen receptor alpha 215524_x_at 4.00E-06 down chondroitin sulfate proteoglycan 2 215646_s_at 8.00E-06 up CSPG2 (versican) phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce 215671_at 2.20E-05 up PDE4B homolog, Drosophila) 215684_s_at 0.000437 down ASC1P100 ASC-1 complex subunit P100 215732_s_at 0.000619 up DTX2 deltex homolog 2 (Drosophila) 215760_s_at 0.000654 up KIAA0963 KIAA0963 succinate-CoA ligase, GDP-forming, 215772_x_at 2.00E-06 down SUCLG2 beta subunit SET translocation (myeloid leukemia- 215780_s_at 3.70E-05 up SET associated)

215783_s_at 2.00E-06 up ALPL alkaline phosphatase, liver/bone/kidney

215785_s_at 2.00E-06 down CYFIP2 cytoplasmic FMR1 interacting protein 2 215806_x_at 2.00E-06 down pregnancy specific beta-1-glycoprotein 215821_x_at 0.000224 up PSG3 3 215823_x_at 1.90E-05 down PABPC1 poly(A) binding protein, cytoplasmic 1 215838_at 3.90E-05 up LIR9 leukocyte Ig-like receptor 9 hematopoietically expressed 215933_s_at 0.000392 up HHEX homeobox 215963_x_at 2.00E-06 down RPL3 ribosomal protein L3 215966_x_at 4.00E-06 up GK glycerol kinase 215977_x_at 1.10E-05 up GK glycerol kinase B-cell CLL/lymphoma 6 (zinc finger 215990_s_at 2.00E-06 up BCL6 protein 51) FYN oncogene related to SRC, FGR, 216033_s_at 4.70E-05 down FYN YES

trinucleotide repeat containing 11 (THR- 216071_x_at 1.10E-05 up TNRC11 associated protein, 230kDa subunit) 216148_at 0.000873 up integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 216178_x_at 8.10E-05 down ITGB1 includes MDF2, MSK12) 216191_s_at 2.00E-06 down TRD@ T cell receptor delta locus mitogen-activated protein kinase 216199_s_at 0.000479 down MAP3K4 kinase kinase 4 serine palmitoyltransferase, long chain 216202_s_at 0.000493 up SPTLC2 base subunit 2 solute carrier family 2 (facilitated 216236_s_at 2.00E-06 up SLC2A14 glucose transporter), member 14 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. 216237_s_at 0.000258 down MCM5 cerevisiae)

216241_s_at 1.30E-05 down TCEA1 transcription elongation factor A (SII), 1 216243_s_at 2.00E-06 up IL1RN interleukin 1 receptor antagonist Pvt1 oncogene homolog, MYC 216249_at 0.000687 up PVT1 activator (mouse) 216250_s_at 9.00E-06 down LPXN leupaxin tumor necrosis factor receptor 216252_x_at 0.000916 up TNFRSF6 superfamily, member 6 216306_x_at 4.80E-05 down PTBP1 polypyrimidine tract binding protein 1 glyoxylate reductase/hydroxypyruvate 216308_x_at 0.000835 down GRHPR reductase 216316_x_at 8.00E-06 up GK glycerol kinase 216329_at 0.000617 up 216342_x_at 2.00E-06 down RPS4X ribosomal protein S4, X-linked 216348_at 2.00E-06 down RPS17 ribosomal protein S17 216351_x_at 0.000346 up DAZ3 deleted in azoospermia 3 216377_x_at 3.90E-05 up ALPPL2 alkaline phosphatase, placental-like 2 216379_x_at 3.90E-05 up 216380_x_at 7.00E-06 down RPS28 ribosomal protein S28 216383_at 0.000716 down RPL18A ribosomal protein L18a prothymosin, alpha (gene sequence 216384_x_at 2.00E-06 down PTMA 28) 216387_x_at 2.00E-06 down LLT1 lectin-like NK cell receptor 216488_s_at 4.90E-05 up ATP11A ATPase, Class VI, type 11A 216505_x_at 2.00E-06 down prothymosin, alpha (gene sequence 216515_x_at 2.00E-06 down PTMA 28) tumor protein, translationally-controlled 216520_s_at 4.90E-05 down TPT1 1 immunoglobulin heavy constant 216541_x_at 2.00E-06 up IGHG1 gamma 1 (G1m marker) immunoglobulin heavy constant 216542_x_at 0.000122 down IGHG1 gamma 1 (G1m marker) 216559_x_at 2.00E-06 down LOC144983 hypothetical protein LOC144983 interferon induced transmembrane 216565_x_at 9.80E-05 up IFITM3 protein 3 (1-8U) 216570_x_at 2.00E-06 down RPL29 ribosomal protein L29 216589_at 2.00E-06 down phenylalanine-tRNA synthetase-like, 216602_s_at 8.70E-05 down FARSLA alpha subunit 216609_at 0.000373 down TXN thioredoxin thioredoxin domain containing 7 216640_s_at 0.000324 down P5 (protein disulfide isomerase) transcription factor 3 (E2A immunoglobulin enhancer binding 216645_at 2.00E-05 up TCF3 factors E12/E47) 216782_at 0.000553 down laminin receptor 1 (ribosomal protein 216806_at 2.00E-06 down LAMR1 SA, 67kDa) ARP3 actin-related protein 3 homolog 216814_at 0.000156 up ACTR3 (yeast) 216824_at 0.000106 up

216841_s_at 2.00E-06 up SOD2 superoxide dismutase 2, mitochondrial cyclin-dependent kinase inhibitor 1C 216894_x_at 2.00E-06 down CDKN1C (p57, Kip2)

216899_s_at 0.000416 up SCAP2 src family associated phosphoprotein 2 RNA polymerase I transcription factor 216902_s_at 8.70E-05 down RRN3 RRN3 suppression of tumorigenicity 14 (colon 216906_at 0.000122 up ST14 carcinoma, matriptase, epithin) RNA polymerase I transcription factor 216908_x_at 0.000512 down RRN3 RRN3 216913_s_at 6.10E-05 down KIAA0690 KIAA0690 216920_s_at 2.00E-06 down 216922_x_at 0.000568 up DAZ3 deleted in azoospermia 3 216925_s_at 0.000248 up TAL1 T-cell acute lymphocytic leukemia 1 PAS domain containing 216945_x_at 0.000205 down PASK serine/threonine kinase Fc fragment of IgG, high affinity Ia, 216950_s_at 2.00E-06 up FCGR1A receptor for (CD64) 216985_s_at 0.000115 up STX3A syntaxin 3A 217019_at 7.00E-06 down RPS4X ribosomal protein S4, X-linked 217022_s_at 9.70E-05 down MGC27165 hypothetical protein MGC27165 protein tyrosine phosphatase, non- 217024_x_at 0.000474 up PTPNS1 receptor type substrate 1 217028_at 0.000356 down CXCR4 chemokine (C-X-C motif) receptor 4 217056_at 0.000668 up 217078_s_at 4.30E-05 down CMRF-35H leukocyte membrane antigen 217092_x_at 0.000118 down RPL7 ribosomal protein L7 217107_at 0.000122 down RPS4X ribosomal protein S4, X-linked 217122_s_at 4.80E-05 down SLC35E2 solute carrier family 35, member E2 calcium/calmodulin-dependent protein 217128_s_at 0.00056 up CAMK1G kinase IG 217143_s_at 2.00E-06 down TRD@ T cell receptor delta locus 217147_s_at 2.00E-06 down TRIM T-cell receptor interacting molecule aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by 217161_x_at 3.50E-05 up AGC1 monoclonal antibody A0122) 217167_x_at 9.00E-06 up GK glycerol kinase 217189_s_at 0.000148 up C1ORF16 chromosome 1 open reading frame 16 signal transducer and activator of 217199_s_at 1.30E-05 up STAT2 transcription 2, 113kDa 217207_s_at 0.000304 up BTNL3 butyrophilin-like 3 217209_at 2.90E-05 up 217225_x_at 2.90E-05 down LOC283820 hypothetical protein LOC283820 immunoglobulin heavy constant 217236_x_at 6.30E-05 up IGHG1 gamma 1 (G1m marker) 217239_x_at 8.20E-05 down 217256_x_at 2.00E-06 down RPL36A ribosomal protein L36a 217266_at 2.80E-05 down RPL15 ribosomal protein L15 217286_s_at 0.000298 down NDRG3 NDRG family member 3 Nijmegen breakage syndrome 1 217299_s_at 3.30E-05 up NBS1 (nibrin) 217301_x_at 6.30E-05 down RBBP4 retinoblastoma binding protein 4 217313_at 4.00E-05 down 217317_s_at 0.000224 down 217336_at 9.00E-06 down RPS10 ribosomal protein S10 217347_at 1.30E-05 down RPL35 ribosomal protein L35 heterogeneous nuclear 217353_at 0.000328 down HNRPA1 ribonucleoprotein A1 217362_x_at 2.50E-05 down 217369_at 1.30E-05 up 217379_at 2.00E-06 down RPL10 ribosomal protein L10 peptidylprolyl isomerase (cyclophilin)- 217407_x_at 0.000684 down PPIL2 like 2 217408_at 9.00E-06 down MRPS18B mitochondrial ribosomal protein S18B cytochrome b-245, beta polypeptide 217431_x_at 5.40E-05 up CYBB (chronic granulomatous disease) 217461_x_at 3.00E-05 down BTF3 basic transcription factor 3 217466_x_at 2.00E-06 down RPS2 ribosomal protein S2 217467_at 0.000365 down BTF3 basic transcription factor 3 217475_s_at 8.00E-06 up LIMK2 LIM domain kinase 2 major histocompatibility complex, class 217478_s_at 2.00E-06 down HLA-DMA II, DM alpha 217491_x_at 2.00E-06 down COX7C cytochrome c oxidase subunit VIIc 217501_at 0.000757 down CIAO1 WD40 protein Ciao1 CD44 antigen (homing function and 217523_at 0.000129 up CD44 Indian blood group system) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 217527_s_at 1.10E-05 down FLJ14639 interacting protein complement component (3b/4b) receptor 1, including Knops blood 217552_x_at 8.00E-06 up CR1 group system 217553_at 6.70E-05 up son of sevenless homolog 2 217644_s_at 0.000866 up SOS2 (Drosophila) 217647_at 9.60E-05 up DHODH dihydroorotate dehydrogenase SWI/SNF related, matrix associated, actin dependent regulator of chromatin, 217707_x_at 3.90E-05 down SMARCA2 subfamily a, member 2 eukaryotic translation initiation factor 3, 217719_at 2.00E-06 down EIF3S6IP subunit 6 interacting protein

217722_s_at 0.000144 down NEUGRIN mesenchymal stem cell protein DSC92 217724_at 2.00E-06 down PAI-RBP1 PAI-1 mRNA-binding protein 217725_x_at 6.10E-05 down PAI-RBP1 PAI-1 mRNA-binding protein coatomer protein complex, subunit zeta 217726_at 0.000308 down COPZ1 1 217727_x_at 6.80E-05 down VPS35 vacuolar protein sorting 35 (yeast) S100 calcium binding protein A6 217728_at 2.00E-06 up S100A6 (calcyclin) 217729_s_at 2.00E-06 down AES amino-terminal enhancer of split 217733_s_at 1.00E-05 down TMSB10 thymosin, beta 10 217734_s_at 1.70E-05 down WDR6 WD repeat domain 6 217740_x_at 2.00E-06 down RPL7A ribosomal protein L7a 217745_s_at 0.000193 down MAK3P Mak3 homolog (S. cerevisiae) programmed cell death 6 interacting 217746_s_at 0.000184 down PDCD6IP protein 217747_s_at 1.30E-05 down RPS9 ribosomal protein S9 217751_at 1.10E-05 down LOC51064 glutathione S-transferase kappa 1 CNDP dipeptidase 2 (metallopeptidase 217752_s_at 2.40E-05 down CN2 M20 family) 217753_s_at 2.00E-06 down RPS26 ribosomal protein S26 217761_at 1.40E-05 down SIPL SIPL protein chromosome 14 open reading frame 217768_at 7.00E-06 down C14ORF166 166 NADH dehydrogenase (ubiquinone) 1 217773_s_at 3.90E-05 down NDUFA4 alpha subcomplex, 4, 9kDa retinol dehydrogenase 11 (all-trans and 217776_at 8.00E-06 down RDH11 9-cis) proline-rich nuclear receptor 217779_s_at 5.10E-05 down PNRC2 coactivator 2 217780_at 0.000229 down PTD008 PTD008 protein 217792_at 4.00E-06 down SNX5 sorting nexin 5 217797_at 4.00E-06 down HSPC155 Ufm1-conjugating enzyme 1 nuclear ubiquitous casein kinase and 217802_s_at 4.90E-05 down NUCKS cyclin-dependent kinase substrate interleukin enhancer binding factor 3, 217805_at 0.000114 down ILF3 90kDa glioma tumor suppressor candidate 217807_s_at 2.00E-06 down GLTSCR2 region gene 2 217809_at 9.00E-06 down BZW2 basic leucine zipper and W2 domains 2 217812_at 0.000845 down HGRG8 YTH domain family 2 suppressor of Ty 16 homolog (S. 217815_at 0.000341 down SUPT16H cerevisiae) 217816_s_at 0.000634 down PCNP PEST-containing nuclear protein ubiquitin-conjugating enzyme E2, J1 217823_s_at 2.00E-06 up UBE2J1 (UBC6 homolog, yeast) ubiquitin-conjugating enzyme E2, J1 217825_s_at 2.00E-06 up UBE2J1 (UBC6 homolog, yeast) ubiquitin-conjugating enzyme E2, J1 217826_s_at 1.70E-05 up UBE2J1 (UBC6 homolog, yeast) synaptotagmin binding, cytoplasmic 217832_at 2.00E-06 down SYNCRIP RNA interacting protein synaptotagmin binding, cytoplasmic 217833_at 0.000523 down SYNCRIP RNA interacting protein chromosome 20 open reading frame 217835_x_at 0.000624 up C20ORF24 24 217838_s_at 2.00E-06 down EVL Enah/Vasp-like DEAD (Asp-Glu-Ala-Asp) box 217840_at 5.40E-05 down DDX41 polypeptide 41 217846_at 2.00E-06 down QARS glutaminyl-tRNA synthetase 217853_at 0.00056 down TENS1 tensin-like SH2 domain containing 1 polymerase (RNA) II (DNA directed) 217854_s_at 3.80E-05 down POLR2E polypeptide E, 25kDa NADH dehydrogenase (ubiquinone) 1 217860_at 0.000188 down NDUFA10 alpha subcomplex, 10, 42kDa 217868_s_at 2.00E-06 up DREV1 DORA reverse strand protein 1 hydroxysteroid (17-beta) 217869_at 0.000323 down HSD17B12 dehydrogenase 12

217870_s_at 2.00E-06 down UMP-CMPK UMP-CMP kinase macrophage migration inhibitory factor 217871_s_at 3.20E-05 down MIF (glycosylation-inhibiting factor) 217872_at 6.10E-05 down FLJ20643 hypothetical protein FLJ20643 217873_at 0.000594 up MO25 MO25 protein 217881_s_at 0.000335 up CDC27 cell division cycle 27 217883_at 0.000109 up CL25022 chromosome 2 open reading frame 25 217884_at 0.000259 down FLJ10774 N-acetyltransferase-like protein 217899_at 0.000982 down FLJ20254 hypothetical protein FLJ20254 217906_at 2.00E-06 down KLHDC2 kelch domain containing 2 217912_at 1.30E-05 down PP3111 PP3111 protein 217914_at 0.000118 down TPCN1 two pore segment channel 1 chromosome 15 open reading frame 217915_s_at 3.90E-05 down C15ORF15 15 PEF protein with a long N-terminal 217923_at 0.00075 up PEF hydrophobic domain (peflin) 217926_at 2.00E-06 down HSPC023 HSPC023 protein 217927_at 2.00E-06 down SPC12 signal peptidase 12kDa 217931_at 0.00089 down TNRC5 trinucleotide repeat containing 5 217933_s_at 0.00026 up LAP3 leucine aminopeptidase 3 STIP1 homology and U-Box containing 217934_x_at 6.10E-05 down STUB1 protein 1 217940_s_at 2.00E-05 down FLJ10769 hypothetical protein FLJ10769 217942_at 0.000231 down MRPS35 mitochondrial ribosomal protein S35 217943_s_at 0.000536 down FLJ10350 hypothetical protein FLJ10350 217945_at 4.00E-06 down BTBD1 BTB (POZ) domain containing 1

217950_at 0.000234 down NOSIP nitric oxide synthase interacting protein likely ortholog of mouse gene trap 217957_at 9.00E-06 down GTL3 locus 3 217959_s_at 0.000651 down TRAPPC4 trafficking protein particle complex 4 217964_at 1.10E-05 down FLJ20343 hypothetical protein FLJ20343 217966_s_at 0.000331 up C1ORF24 chromosome 1 open reading frame 24 217967_s_at 0.000182 up C1ORF24 chromosome 1 open reading frame 24 217969_at 7.00E-06 down C11ORF2 chromosome 11 open reading frame2 coiled-coil-helix-coiled-coil-helix 217972_at 3.30E-05 down CHCHD3 domain containing 3 217973_at 7.60E-05 down DCXR dicarbonyl/L-xylulose reductase 217977_at 1.50E-05 up SEPX1 selenoprotein X, 1 ubiquitin-conjugating enzyme E2Q 217978_s_at 0.000103 down UBE2Q (putative) 217983_s_at 4.20E-05 down RNASET2 ribonuclease T2 217984_at 3.20E-05 down RNASET2 ribonuclease T2 218005_at 2.00E-06 down ZNF22 zinc finger protein 22 (KOX 15) 218007_s_at 2.00E-06 down RPS27L ribosomal protein S27-like chromosome 20 open reading frame 218010_x_at 7.40E-05 down C20ORF149 149 218014_at 0.000186 down PCNT1 pericentrin 1 polymerase (RNA) III (DNA directed) 218016_s_at 2.00E-06 down RPC5 polypeptide E (80kD) 218017_s_at 0.000281 down FLJ32731 hypothetical protein FLJ32731 pyridoxal (pyridoxine, vitamin B6) 218018_at 2.00E-06 up PDXK kinase 218019_s_at 3.40E-05 down C21ORF97 218024_at 0.000115 down BRP44L brain protein 44-like peroxisomal D3,D2-enoyl-CoA 218025_s_at 4.00E-05 down PECI isomerase 218027_at 9.30E-05 down MRPL15 mitochondrial ribosomal protein L15 chromosome 14 open reading frame 218031_s_at 9.00E-06 down C14ORF116 116 218033_s_at 0.000144 up SNN stannin 218034_at 3.80E-05 down TTC11 tetratricopeptide repeat domain 11 218035_s_at 2.40E-05 up FLJ20273 RNA-binding protein COP9 constitutive photomorphogenic 218042_at 0.000265 down COPS4 homolog subunit 4 (Arabidopsis) 218048_at 9.40E-05 down C10ORF8 COMM domain containing 3 218050_at 1.80E-05 down BM-002 ubiquitin-fold modifier 1 218058_at 0.000277 down CGBP CXXC finger 1 (PHD domain) 218059_at 2.00E-06 down LOC51123 HSPC038 protein 218060_s_at 0.000878 up FLJ13154 hypothetical protein FLJ13154 218061_at 2.80E-05 down MEA male-enhanced antigen 218067_s_at 7.20E-05 down FLJ10154 hypothetical protein FLJ10154 218074_at 0.000169 down CGI-128 CGI-128 protein

218077_s_at 2.10E-05 up ZDHHC3 zinc finger, DHHC domain containing 3

218078_s_at 2.00E-06 up ZDHHC3 zinc finger, DHHC domain containing 3 chromosome 20 open reading frame 218081_at 0.000279 down C20ORF27 27 218082_s_at 1.10E-05 down UBP1 upstream binding protein 1 (LBP-1a) FXYD domain containing ion transport 218084_x_at 2.00E-06 down FXYD5 regulator 5 218091_at 8.90E-05 up HRB HIV-1 Rev binding protein 218092_s_at 1.10E-05 up HRB HIV-1 Rev binding protein 218096_at 8.00E-06 down LPAAT-E acid acyltransferase-epsilon NADH dehydrogenase (ubiquinone) 1, 218101_s_at 0.000342 down NDUFC2 subcomplex unknown, 2, 14.5kDa 218102_at 8.00E-06 down CGI-26 CGI-26 protein chromosome 14 open reading frame 218108_at 8.00E-06 down C14ORF130 130 218116_at 3.30E-05 down C9ORF78 chromosome 9 open reading frame 78 218117_at 0.000829 down RBX1 ring-box 1 218136_s_at 8.60E-05 down MSCP mitochondrial solute carrier protein signal recognition particle receptor, B 218140_x_at 0.000115 down SRPRB subunit 218147_s_at 2.00E-06 down AD-017 glycosyltransferase AD-017 218149_s_at 2.00E-06 down PBF zinc finger protein 395 218152_at 4.00E-06 down HMG20A high-mobility group 20A 218165_at 0.000329 down FLJ11730 hypothetical protein FLJ11730 218177_at 0.000483 down CHMP1.5 CHMP1.5 protein 218179_s_at 0.000385 down FLJ12716 FLJ12716 protein 218184_at 0.000513 down TULP4 tubby like protein 4 218185_s_at 4.90E-05 down FLJ10511 armadillo repeat containing protein N-acetylneuraminic acid synthase 218189_s_at 4.40E-05 down NANS (sialic acid synthase) ubiquinol-cytochrome c reductase 218190_s_at 4.20E-05 down HSPC051 complex (7.2 kD) 218193_s_at 0.000104 down CGI-141 CGI-141 protein DKFZP566E 218194_at 2.00E-06 down 144 small fragment nuclease 218197_s_at 0.000514 down OXR1 oxidation resistance 1 NADH dehydrogenase (ubiquinone) 1 218200_s_at 2.00E-06 down NDUFB2 beta subcomplex, 2, 8kDa NADH dehydrogenase (ubiquinone) 1 218201_at 1.80E-05 down NDUFB2 beta subcomplex, 2, 8kDa chromosome 12 open reading frame 218220_at 0.000183 down C12ORF10 10 218224_at 0.000182 down PNMA1 paraneoplastic antigen MA1 NADH dehydrogenase (ubiquinone) 1 218226_s_at 1.70E-05 down NDUFB4 beta subcomplex, 4, 15kDa pogo transposable element with KRAB 218229_s_at 0.000132 down POGK domain 218233_s_at 2.00E-06 down C6ORF49 chromosome 6 open reading frame 49 218237_s_at 2.10E-05 down SLC38A1 solute carrier family 38, member 1 218239_s_at 0.000454 down GTPBP4 GTP binding protein 4

218247_s_at 0.000498 down LOC51320 ring finger and KH domain containing 2 CCR4-NOT transcription complex, 218250_s_at 2.00E-06 down CNOT7 subunit 7 218256_s_at 8.00E-06 down NUP54 nucleoporin 54kDa polymerase (RNA) I polypeptide D, 218258_at 2.00E-06 down POLR1D 16kDa transposon-derived Buster1 218263_s_at 0.000259 down LOC58486 transposase-like protein 218268_at 2.00E-06 up TBC1D15 TBC1 domain family, member 15 218269_at 0.000835 down RNASE3L nuclear RNase III Drosha 218270_at 0.00022 down MRPL24 mitochondrial ribosomal protein L24 218271_s_at 0.000219 down PSARL presenilin associated, rhomboid-like 218280_x_at 2.00E-06 up HIST2H2AA histone 2, H2aa synovial sarcoma translocation gene 218283_at 0.000897 down SS18L2 on chromosome 18-like 2 eukaryotic translation initiation factor 218287_s_at 0.000557 down EIF2C1 2C, 1 218302_at 0.000844 up PEN2 presenilin enhancer 2 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain 218306_s_at 3.00E-05 down HERC1 and RCC1 (CHC1)-like domain (RLD) 1 RAB guanine nucleotide exchange 218310_at 3.10E-05 up RABGEF1 factor (GEF) 1 218312_s_at 3.50E-05 down FLJ12895 hypothetical protein FLJ12895 CDK5 regulatory subunit associated 218315_s_at 0.000206 down CDK5RAP1 protein 1 translocase of inner mitochondrial 218316_at 0.000753 down TIMM9 membrane 9 homolog (yeast) 218317_x_at 8.90E-05 down MGC5178 hypothetical protein MGC5178 218320_s_at 0.000251 down P17.3 neuronal protein 17.3 chromosome 10 open reading frame 218331_s_at 0.000915 down FLJ20360 18 218346_s_at 0.000151 down SESN1 sestrin 1 218351_at 1.30E-05 down FLJ20502 COMM domain containing 8 218356_at 2.00E-06 down FTSJ2 FtsJ homolog 2 (E. coli) 218366_x_at 1.10E-05 down FLJ20859 FLJ20859 gene PRKR interacting protein 1 (IL11 218378_s_at 3.90E-05 down PRKRIP1 inducible) chromosome 14 open reading frame 218383_at 2.80E-05 down C14ORF94 94 calcium regulated heat stable protein 218384_at 0.000973 down CARHSP1 1, 24kDa 218386_x_at 0.000167 down USP16 ubiquitin specific protease 16 218387_s_at 4.00E-06 down PGLS 6-phosphogluconolactonase 218388_at 0.000265 down PGLS 6-phosphogluconolactonase 218392_x_at 4.90E-05 up SFXN1 sideroflexin 1 ARP6 actin-related protein 6 homolog 218395_at 0.000173 down ACTR6 (yeast) 218396_at 2.00E-06 down FLJ20136 vacuolar protein sorting 13C (yeast) 2'-5'-oligoadenylate synthetase 3, 218400_at 8.00E-06 up OAS3 100kDa 218401_s_at 1.10E-05 up ZNF281 zinc finger protein 281 218404_at 0.000594 up SNX10 sorting nexin 10 nudE nuclear distribution gene E 218414_s_at 0.000811 down NDE1 homolog 1 (A. nidulans) chromosome 13 open reading frame 218422_s_at 0.000451 down C13ORF10 10 218428_s_at 0.00029 down REV1L REV1-like (yeast) methylcrotonoyl-Coenzyme A 218440_at 0.000117 down MCCC1 carboxylase 1 (alpha) 218443_s_at 0.000263 down DAZAP1 DAZ associated protein 1 218450_at 2.00E-06 down HEBP1 heme binding protein 1 218454_at 9.00E-06 up FLJ22662 hypothetical protein FLJ22662 218456_at 0.000295 down C1QDC1 C1q domain containing 1 218462_at 5.10E-05 down RPF1 RNA processing factor 1 tumor necrosis factor superfamily, 218467_at 2.00E-06 down HCCA3 member 5-induced protein 1 218472_s_at 0.00027 down PELO pelota homolog (Drosophila) DKFZP434E 218478_s_at 0.000355 down 2220 zinc finger, CCHC domain containing 8 218487_at 0.000112 down ALAD aminolevulinate, delta-, dehydratase 218490_s_at 0.000122 down ZNF302 zinc finger protein 302 218494_s_at 0.000403 down SLC2A4RG SLC2A4 regulator 218495_at 4.80E-05 down UXT ubiquitously-expressed transcript 218502_s_at 5.30E-05 down TRPS1 trichorhinophalangeal syndrome I 218505_at 0.000381 down FLJ12270 hypothetical protein FLJ12270 chromosome 21 open reading frame 218515_at 0.00035 down C21ORF66 66 218517_at 4.00E-05 down JADE1 PHD finger protein 17 218521_s_at 0.000528 up FLJ11011 hypothetical protein FLJ11011 218533_s_at 0.000219 down URKL1 uridine kinase-like 1 218545_at 3.30E-05 down FLJ11088 GGA binding partner v-maf musculoaponeurotic fibrosarcoma oncogene homolog B 218559_s_at 0.000769 down MAFB (avian) 218562_s_at 0.000441 down FLJ10747 hypothetical protein FLJ10747 218577_at 5.40E-05 down FLJ20331 hypothetical protein FLJ20331

218578_at 5.50E-05 up C1ORF28 hyperparathyroidism 2 (with jaw tumor) chromosome 20 open reading frame 218586_at 0.000259 down C20ORF20 20 purinergic receptor P2Y, G-protein 218589_at 2.00E-06 down P2RY5 coupled, 5 218605_at 0.000493 down TFB2M transcription factor B2, mitochondrial 218611_at 3.30E-05 down IER5 immediate early response 5 218618_s_at 4.00E-06 up FAD104 FAD104 dysferlin, limb girdle muscular 218660_at 2.00E-06 up DYSF dystrophy 2B (autosomal recessive) 218670_at 4.40E-05 down PUS1 pseudouridylate synthase 1 218671_s_at 0.000113 down ATPIF1 ATPase inhibitory factor 1

218673_s_at 0.000194 up APG7L APG7 autophagy 7-like (S. cerevisiae) 218679_s_at 0.000984 down VPS28 vacuolar protein sorting 28 (yeast) 218684_at 0.000506 down LRRC5 leucine rich repeat containing 5 RAB7, member RAS oncogene family- 218700_s_at 0.00096 down RAB7L1 like 1 218712_at 1.10E-05 down FLJ20508 hypothetical protein FLJ20508 218713_at 4.70E-05 down NARG2 NMDA receptor-regulated gene 2 hepatocellular carcinoma-associated 218715_at 2.00E-06 down HCA66 antigen 66 mitochondrial translation optimization 1 218716_x_at 0.00016 down MTO1 homolog (S. cerevisiae) 218723_s_at 2.00E-06 down RGC32 response gene to complement 32 218728_s_at 2.00E-06 up HSPC163 HSPC163 protein 218747_s_at 7.90E-05 down TAPBP-R TAP binding protein-like 218764_at 5.70E-05 down PRKCH protein kinase C, eta 218765_at 2.00E-06 down CGI-40 CGI-40 protein 218771_at 0.000334 down PANK4 pantothenate kinase 4 218773_s_at 0.00029 up MSRB methionine sulfoxide reductase B

218793_s_at 0.000101 down SCML1 sex comb on midleg-like 1 (Drosophila) 218802_at 2.00E-06 down FLJ20647 hypothetical protein FLJ20647 immune associated nucleotide 4 like 1 218805_at 9.00E-06 down IAN4L1 (mouse) 218810_at 2.00E-06 up FLJ23231 hypothetical protein FLJ23231 218836_at 2.00E-06 down C6ORF135 ribonuclease P 21kDa subunit 218842_at 1.30E-05 down FLJ21908 hypothetical protein FLJ21908 squamous cell carcinoma antigen 218854_at 0.000822 up SART2 recognized by T cells 2 218865_at 2.00E-06 up FLJ22390 hypothetical protein FLJ22390 polymerase (RNA) III (DNA directed) 218866_s_at 8.10E-05 down POLR3K polypeptide K, 12.3 kDa 218877_s_at 2.00E-05 down C6ORF75 chromosome 6 open reading frame 75 218880_at 2.00E-06 up FOSL2 FOS-like antigen 2 218881_s_at 2.00E-06 up FOSL2 FOS-like antigen 2 218882_s_at 2.00E-06 down WDR3 WD repeat domain 3 chromosome 10 open reading frame 218889_at 3.90E-05 down AD24 117 mannosidase, alpha, class 1C, 218918_at 1.10E-05 down MAN1C1 member 1 218921_at 1.30E-05 down SIGIRR single Ig IL-1R-related molecule collaborates/cooperates with ARF 218929_at 5.80E-05 down CARF (alternate reading frame) protein 218930_s_at 8.70E-05 down FLJ11273 hypothetical protein FLJ11273 218941_at 2.90E-05 up FBXW2 F-box and WD-40 domain protein 2 DEAD (Asp-Glu-Ala-Asp) box 218943_s_at 0.000242 up RIG-I polypeptide 58 218944_at 0.000919 up FLJ13852 pyrroline-5-carboxylate reductase-like 218978_s_at 4.00E-05 up MSCP mitochondrial solute carrier protein 218981_at 2.00E-06 up ACN9 ACN9 homolog (S. cerevisiae) 218986_s_at 0.00011 up FLJ20035 hypothetical protein FLJ20035 218992_at 2.00E-06 up C9ORF46 chromosome 9 open reading frame 46 218995_s_at 3.50E-05 up EDN1 endothelin 1 218999_at 0.000598 up FLJ11000 hypothetical protein FLJ11000 219002_at 0.000329 down FLJ21901 hypothetical protein FLJ21901 219006_at 0.000331 down C6ORF66 chromosome 6 open reading frame 66 219007_at 2.80E-05 down NUP43 nucleoporin 43kDa 219014_at 2.00E-06 down PLAC8 placenta-specific 8 219029_at 0.000107 down FLJ21657 hypothetical protein FLJ21657 219034_at 0.000345 up FLJ20509 hypothetical protein FLJ20509 219040_at 0.000475 down FLJ22021 hypothetical protein FLJ22021 219041_s_at 0.000971 down REPIN1 replication initiator 1 219043_s_at 2.00E-06 down VIAF1 phosducin-like 3 219044_at 8.00E-05 up FLJ10916 hypothetical protein FLJ10916 ras homolog gene family, member F (in 219045_at 1.80E-05 down ARHF filopodia) 219064_at 5.80E-05 up ITIH5 inter-alpha (globulin) inhibitor H5 chromosome 10 open reading frame 219067_s_at 2.00E-06 down FLJ20003 86 219093_at 0.000654 down FLJ20701 hypothetical protein FLJ20701 oligonucleotide/oligosaccharide-binding 219100_at 1.50E-05 down FLJ22559 fold containing 1 DEAD (Asp-Glu-Ala-Asp) box 219111_s_at 0.000594 down DDX54 polypeptide 54 RAB, member of RAS oncogene family- 219151_s_at 4.90E-05 down RABL2B like 2B 219157_at 0.000167 up KLHL2 kelch-like 2, Mayven (Drosophila) pleckstrin homology, Sec7 and coiled- 219183_s_at 0.00013 down PSCD4 coil domains 4 219192_at 4.20E-05 down UBAP2 ubiquitin associated protein 2 219202_at 0.000598 up FLJ22341 rhomboid-like protein 6

219210_s_at 0.000682 up RAB8B RAB8B, member RAS oncogene family 219242_at 1.10E-05 down FLJ13386 hypothetical protein FLJ13386 219243_at 0.000101 down HIMAP4 immunity associated protein 4 219253_at 0.00012 up 219279_at 1.10E-05 down DOCK10 dedicator of cytokinesis 10 chromosome 21 open reading frame 219280_at 0.000784 down C21ORF107 107 219281_at 2.00E-06 up MSRA methionine sulfoxide reductase A core 1 UDP-galactose:N- acetylgalactosamine-alpha-R beta 1,3- 219283_at 2.30E-05 up C1GALT2 galactosyltransferase 2 219286_s_at 9.40E-05 down RBM15 RNA binding motif protein 15 219289_at 0.000358 down FLJ20718 hypothetical protein FLJ20718 THAP domain containing, apoptosis 219292_at 0.000552 up THAP1 associated protein 1 219293_s_at 2.00E-06 down PTD004 hypothetical protein PTD004 219304_s_at 0.000359 down PDGFD platelet derived growth factor D chromosome 6 open reading frame 219307_at 0.000668 down C6ORF210 210 219315_s_at 2.00E-06 down FLJ20898 hypothetical protein FLJ20898 219322_s_at 0.000394 down WDR8 WD repeat domain 8 219329_s_at 2.00E-06 down 3-Apr chromosome 2 open reading frame 28 219334_s_at 0.00041 up FLJ22833 hypothetical protein FLJ22833 219359_at 0.000199 down FLJ22635 hypothetical protein FLJ22635 219386_s_at 0.000286 up SLAMF8 SLAM family member 8 phosphatidylglycerophosphate 219394_at 0.000352 down PGS1 synthase 219403_s_at 2.80E-05 down HPSE heparanase tumor necrosis factor receptor 219423_x_at 6.00E-06 down TNFRSF25 superfamily, member 25 219433_at 0.000358 down BCOR BCL6 co-repressor 219452_at 2.00E-06 down DPEP2 dipeptidase 2 chromosome 13 open reading frame 219471_at 3.20E-05 up C13ORF18 18 219487_at 0.000666 down FLJ23560 hypothetical protein FLJ23560 cat eye syndrome chromosome region, 219505_at 2.00E-06 down CECR1 candidate 1 B-cell CLL/lymphoma 11B (zinc finger 219528_s_at 2.00E-06 down BCL11B protein) cyclin-dependent kinase inhibitor 1C 219534_x_at 2.00E-06 down CDKN1C (p57, Kip2) 219549_s_at 1.30E-05 up RTN3 reticulon 3 chromosome 14 open reading frame 219563_at 0.000354 down C14ORF139 139 219593_at 0.000215 up SLC15A3 solute carrier family 15, member 3 219598_s_at 2.00E-06 down RWDD1 RWD domain containing 1 membrane-spanning 4-domains, 219607_s_at 3.90E-05 up MS4A4A subfamily A, member 4 interleukin-1 receptor-associated 219618_at 0.000186 up IRAK4 kinase 4

219622_at 2.80E-05 up RAB20 RAB20, member RAS oncogene family B-cell scaffold protein with ankyrin 219667_s_at 4.00E-05 down BANK1 repeats 1 ganglioside-induced differentiation- 219668_at 1.10E-05 up GDAP1L1 associated protein 1-like 1 219669_at 2.00E-06 up PRV1 polycythemia rubra vera 1 219690_at 4.70E-05 up FLJ22573 hypothetical protein FLJ22573 219691_at 0.00025 up FLJ20073 FLJ20073 protein 219716_at 0.000171 up APOL6 apolipoprotein L, 6 219734_at 5.50E-05 down FLJ20174 hypothetical protein FLJ20174 triggering receptor expressed on 219748_at 0.000126 up C6ORF76 myeloid cells-like 2 RAS protein activator like 1 (GAP1 219752_at 0.000179 up RASAL1 like) chromosome 14 open reading frame 219757_s_at 2.00E-06 up C14ORF101 101 219762_s_at 2.00E-06 down RPL36 ribosomal protein L36 219770_at 0.000224 up FLJ11753 glycosyltransferase-like 1 human immune associated nucleotide 219777_at 2.00E-06 down HIAN2 2 219791_s_at 0.000975 up FLJ11539 hypothetical protein FLJ11539 dehydrogenase/reductase (SDR family) 219799_s_at 0.000563 up DHRS9 member 9 219802_at 0.000147 down FLJ22028 hypothetical protein FLJ22028 219806_s_at 4.00E-06 up FN5 FN5 protein valosin-containing protein (p97)/p47 219810_at 2.00E-06 up VCIP135 complex-interacting protein p135 219812_at 2.00E-06 down STAG3 stromal antigen 3 219818_s_at 1.80E-05 down ECGP G patch domain containing 1 C-type (calcium dependent, carbohydrate-recognition domain) 219859_at 1.10E-05 up CLECSF9 lectin, superfamily member 9 219862_s_at 5.30E-05 up NARF nuclear prelamin A recognition factor 219863_at 0.000185 up CEB1 hect domain and RLD 5 solute carrier family 39 (zinc 219869_s_at 6.10E-05 up SLC39A8 transporter), member 8 DKFZP434L 219872_at 0.000501 up 142 hypothetical protein DKFZp434L142 frequently rearranged in advanced T- 219889_at 0.000101 down FRAT1 cell lymphomas C-type (calcium dependent, carbohydrate-recognition domain) 219890_at 4.70E-05 up CLECSF5 lectin, superfamily member 5 transmembrane 6 superfamily member 219892_at 0.000221 up TM6SF1 1 latent transforming growth factor beta 219922_s_at 1.30E-05 down LTBP3 binding protein 3 219924_s_at 1.50E-05 down ZNF258 zinc finger protein 258 proline-serine-threonine phosphatase 219938_s_at 2.00E-06 up PSTPIP2 interacting protein 2 219939_s_at 0.000528 down D1S155E NRAS-related gene 219957_at 0.000115 down RUFY2 RUN and FYVE domain containing 2 219975_x_at 2.00E-06 up FLJ11106 thioesterase domain containing 1 219988_s_at 7.70E-05 down FLJ10597 hypothetical protein FLJ10597 220000_at 3.90E-05 up SIGLEC5 sialic acid binding Ig-like lectin 5 220001_at 2.00E-06 up PADI4 peptidyl arginine deiminase, type IV 220005_at 2.40E-05 up GPR86 G protein-coupled receptor 86 interleukin-1 receptor-associated 220034_at 2.00E-06 up IRAK3 kinase 3 220035_at 3.00E-05 down NUP210 nucleoporin 210 serum/glucocorticoid regulated kinase- 220038_at 0.00018 down SGKL like cisplatin resistance-associated 220044_x_at 1.10E-05 down LUC7A overexpressed protein 220046_s_at 0.000737 up CCNL1 cyclin L1 TERF1 (TRF1)-interacting nuclear 220052_s_at 0.000329 up TINF2 factor 2 220104_at 0.000337 up ZC3HAV1 zinc finger CCCH type, antiviral 1 220122_at 2.00E-06 up FLJ22344 hypothetical protein FLJ22344 220132_s_at 0.000665 down LLT1 lectin-like NK cell receptor 220146_at 4.10E-05 down TLR7 toll-like receptor 7 chromosome 12 open reading frame 220147_s_at 4.00E-06 down C12ORF14 14 220155_s_at 0.000513 down BRD9 bromodomain containing 9 caspase recruitment domain family, 220162_s_at 0.000148 down CARD9 member 9 220175_s_at 2.50E-05 down LOC55871 COBW-like protein

likely ortholog of mouse tumor necrosis- 220187_at 8.00E-06 up FLJ23153 alpha-induced adipose-related protein 220211_at 0.000332 up FLJ13224 hypothetical protein FLJ13224 220237_at 0.000594 up APG3 autophagy Apg3p/Aut1p-like loss of heterozygosity, 3, chromosomal 220244_at 2.50E-05 up LOH3CR2A region 2, gene A 220298_s_at 0.00049 up SPATA6 spermatogenesis associated 6 220302_at 1.80E-05 down MAK male germ cell-associated kinase 220307_at 1.70E-05 down CD244 CD244 natural killer cell receptor 2B4 220326_s_at 3.00E-05 down FLJ10357 hypothetical protein FLJ10357 SAM domain, SH3 domain and nuclear 220330_s_at 2.00E-06 up SAMSN1 localisation signals, 1 220367_s_at 0.000663 down SAP130 mSin3A-associated protein 130 thioredoxin domain containing 3 220384_at 8.00E-06 up TXNDC3 (spermatozoa) 220404_at 8.70E-05 up GPR97 G protein-coupled receptor 97 ubiquitin associated and SH3 domain 220418_at 6.90E-05 down UBASH3A containing, A solute carrier family 28 (sodium- coupled nucleoside transporter), 220475_at 0.00045 up SLC28A3 member 3 220476_s_at 1.90E-05 down LOC55924 hypothetical protein LOC55924 220485_s_at 0.000861 down SIRPB2 signal-regulatory protein beta 2 220495_s_at 1.30E-05 down FLJ22625 chromosome 5 open reading frame 14 DKFZP434H 220499_at 0.000412 up 2215 hypothetical protein DKFZp434H2215 RAB, member of RAS oncogene family- 220500_s_at 2.00E-06 down RABL2A like 2A 220507_s_at 1.20E-05 up UPB1 ureidopropionase, beta 220526_s_at 2.30E-05 down MRPL20 mitochondrial ribosomal protein L20 220528_at 0.000104 up VNN3 vanin 3 family with sequence similarity 35, 220547_s_at 8.00E-06 down MGC5560 member A chromosome 11 open reading frame 220560_at 5.10E-05 down C11ORF21 21 ADP-ribosylation-like factor 6 220597_s_at 0.00021 down ARL6IP4 interacting protein 4 220603_s_at 2.00E-06 up FLJ11175 hypothetical protein FLJ11175 leucine rich repeat (in FLII) interacting 220610_s_at 3.00E-05 up LRRFIP2 protein 2 220615_s_at 0.000394 down FLJ10462 male sterility domain containing 1 killer cell lectin-like receptor subfamily 220646_s_at 2.00E-06 down KLRF1 F, member 1 220683_at 0.00038 up RDH8 retinol dehydrogenase 8 (all-trans) chromosome 10 open reading frame 220703_at 8.40E-05 up HT009 110 solute carrier family 12 (potassium/chloride transporters), 220740_s_at 9.10E-05 up SLC12A6 member 6 220741_s_at 0.000938 down PPA2 inorganic pyrophosphatase 2 220746_s_at 6.80E-05 down RAP80 receptor associated protein 80 220755_s_at 2.00E-06 down C6ORF48 chromosome 6 open reading frame 48 220760_x_at 0.000123 down FLJ14345 hypothetical protein FLJ14345 protein phosphatase 4, regulatory 220764_at 2.00E-06 up PPP4R2 subunit 2 220832_at 2.00E-06 up TLR8 toll-like receptor 8 220864_s_at 0.000126 down GRIM19 cell death-regulatory protein GRIM19 220871_at 2.80E-05 up DEAD (Asp-Glu-Ala-Asp) box 220890_s_at 2.90E-05 down DDX47 polypeptide 47 MAK10 homolog, amino-acid N- acetyltransferase subunit, (S. 220925_at 0.000255 down FLJ21613 cerevisiae)

220933_s_at 3.90E-05 down ZCCHC6 zinc finger, CCHC domain containing 6 chromosome 21 open reading frame 220941_s_at 0.000119 up C21ORF91 91 growth and transformation-dependent 220942_x_at 2.00E-06 down E2IG5 protein paired immunoglobin-like type 2 220954_s_at 0.000454 down PILRB receptor beta

220955_x_at 0.000657 up RAB23 RAB23, member RAS oncogene family 220960_x_at 2.00E-06 down RPL22 ribosomal protein L22 actin related protein 2/3 complex, 220966_x_at 0.000846 down ARPC5L subunit 5-like DKFZP564A 220985_s_at 2.00E-05 down 022 hypothetical protein DKFZp564A022 likely ortholog of rat SNF1/AMP- 220987_s_at 8.00E-05 down SNARK activated protein kinase 220998_s_at 0.000365 up UNC93B1 unc-93 homolog B1 (C. elegans)

220999_s_at 1.70E-05 down CYFIP2 cytoplasmic FMR1 interacting protein 2 likely ortholog of mouse limb-bud and 221011_s_at 2.00E-06 down LBH heart gene 221012_s_at 0.000584 down TRIM8 tripartite motif-containing 8 221020_s_at 2.00E-05 down MFTC mitochondrial folate transporter/carrier 221028_s_at 0.000377 up MGC11335 hypothetical protein MGC11335 solute carrier family 17 (anion/sugar 221041_s_at 3.30E-05 up SLC17A5 transporter), member 5 221050_s_at 0.000568 up GTPBP2 GTP binding protein 2 carbohydrate (N-acetylglucosamine 6- 221059_s_at 0.000298 down CHST6 O) sulfotransferase 6 221060_s_at 1.50E-05 up TLR4 toll-like receptor 4 family with sequence similarity 31, 221080_s_at 0.000911 down FAM31C member C 221087_s_at 0.000718 down APOL3 apolipoprotein L, 3 221119_at 0.000119 up FLJ20184 hypothetical protein FLJ20184 a disintegrin and metalloproteinase 221128_at 2.90E-05 down ADAM19 domain 19 (meltrin beta) 221140_s_at 3.20E-05 up GPR132 G protein-coupled receptor 132 221190_s_at 2.80E-05 down C18ORF8 chromosome 18 open reading frame 8 221203_s_at 2.80E-05 down FLJ10201 hypothetical protein FLJ10201 221208_s_at 3.30E-05 down FLJ23342 hypothetical protein FLJ23342 221218_s_at 2.00E-06 up TPK1 thiamin pyrophosphokinase 1 221229_s_at 0.000114 down FLJ20628 hypothetical protein FLJ20628 BTB and CNC homology 1, basic 221234_s_at 2.00E-06 down BACH2 leucine zipper transcription factor 2 221253_s_at 0.000248 down TXNDC5 thioredoxin domain containing 5 221263_s_at 0.000197 down SF3B5 splicing factor 3b, subunit 5, 10kDa 221264_s_at 0.000783 down TARDBP TAR DNA binding protein chromosome 19 open reading frame 221267_s_at 2.00E-06 down MGC5244 27 ribonuclease L (2',5'-oligoisoadenylate 221287_at 8.90E-05 up RNASEL synthetase-dependent) 221345_at 5.10E-05 up GPR43 G protein-coupled receptor 43 221364_at 3.40E-05 up GRID2 glutamate receptor, ionotropic, delta 2 221385_s_at 9.00E-06 up GPR41 G protein-coupled receptor 41 221410_x_at 0.000594 up PCDHB3 protocadherin beta 3 221430_s_at 0.000736 up RNF146 ring finger protein 146 221432_s_at 0.000131 up SLC25A28 solute carrier family 25, member 28 chromosome 14 open reading frame 221434_s_at 1.00E-05 down DC50 156 221452_s_at 2.20E-05 down TMEM14B transmembrane protein 14B wingless-type MMTV integration site 221455_s_at 0.000507 up WNT3 family, member 3 221475_s_at 2.00E-06 down RPL15 ribosomal protein L15 221476_s_at 2.00E-06 down RPL15 ribosomal protein L15 heterogeneous nuclear ribonucleoprotein D (AU-rich element 221481_x_at 0.000354 down HNRPD RNA binding protein 1, 37kDa) 221483_s_at 3.70E-05 down ARPP-19 cyclic AMP phosphoprotein, 19 kD UDP-Gal:betaGlcNAc beta 1,4- 221484_at 9.00E-06 up B4GALT5 galactosyltransferase, polypeptide 5 UDP-Gal:betaGlcNAc beta 1,4- 221485_at 3.10E-05 up B4GALT5 galactosyltransferase, polypeptide 5 221488_s_at 1.10E-05 down C6ORF82 chromosome 6 open reading frame 82 221497_x_at 8.00E-06 down EGLN1 egl nine homolog 1 (C. elegans) 221501_x_at 0.000834 down 221502_at 3.10E-05 down KPNA3 karyopherin alpha 3 (importin alpha 4) transportin 2 (importin 3, karyopherin 221506_s_at 0.000677 down TNPO2 beta 2b) 221508_at 0.000429 down JIK STE20-like kinase 221510_s_at 0.000567 down GLS glutaminase DKFZP564D 221512_at 0.000551 down 0478 hypothetical protein DKFZp564D0478 DKFZP434L ankyrin repeat domain 27 (VPS9 221522_at 0.000181 down 0718 domain) 221523_s_at 0.000375 up RRAGD Ras-related GTP binding D 221524_s_at 6.70E-05 up RRAGD Ras-related GTP binding D engulfment and cell motility 2 (ced-12 221528_s_at 0.000876 up ELMO2 homolog, C. elegans) 221531_at 5.30E-05 down REC14 recombination protein REC14 221536_s_at 0.000232 down FLJ11301 hypothetical protein FLJ11301 general transcription factor IIH, 221540_x_at 6.90E-05 down GTF2H2 polypeptide 2, 44kDa DKFZP434B 221541_at 0.000383 up 044 hypothetical protein DKFZp434B044 integrin-linked kinase-associated 221548_s_at 2.50E-05 down ILKAP serine/threonine phosphatase 2C 221558_s_at 2.00E-06 down LEF1 lymphoid enhancer-binding factor 1 family with sequence similarity 26, 221565_s_at 0.000241 down LOC51063 member B 221580_s_at 0.000123 down MGC5306 hypothetical protein MGC5306 aldehyde dehydrogenase 6 family, 221589_s_at 9.30E-05 down ALDH6A1 member A1 221601_s_at 2.00E-06 down TOSO regulator of Fas-induced apoptosis 221602_s_at 1.10E-05 down TOSO regulator of Fas-induced apoptosis 221614_s_at 0.000989 up RPH3AL rabphilin 3A-like (without C2 domains) 221637_s_at 0.000104 down MGC2477 hypothetical protein MGC2477 arginine-glutamic acid dipeptide (RE) 221643_s_at 0.000148 up RERE repeats 221651_x_at 1.70E-05 down IGKC immunoglobulin kappa constant 221652_s_at 2.00E-05 down FLJ10637 hypothetical protein FLJ10637 221653_x_at 0.00099 up APOL2 apolipoprotein L, 2 apoptosis-associated speck-like 221666_s_at 0.000505 down ASC protein containing a CARD 221671_x_at 4.70E-05 down 221680_s_at 0.000274 up ETV7 ets variant gene 7 (TEL2 oncogene) chromosome 15 open reading frame 221688_s_at 0.00026 down C15ORF12 12 nucleophosmin (nucleolar 221691_x_at 2.00E-06 down NPM1 phosphoprotein B23, numatrin) 221692_s_at 2.00E-06 down MRPL34 mitochondrial ribosomal protein L34 DEAD (Asp-Glu-Ala-Asp) box 221699_s_at 0.000311 down DDX50 polypeptide 50 ubiquitin A-52 residue ribosomal 221700_s_at 2.00E-06 down UBA52 protein fusion product 1 221711_s_at 2.80E-05 down HSPC142 HSPC142 protein 221726_at 2.00E-06 down RPL22 ribosomal protein L22 chondroitin sulfate proteoglycan 2 221731_x_at 2.90E-05 down CSPG2 (versican) 221746_at 0.000129 down UBL4 ubiquitin-like 4 221754_s_at 2.00E-06 down CORO1B coronin, actin binding protein, 1B 221756_at 2.00E-06 down LIMK2 LIM domain kinase 2 mannosidase, alpha, class 1A, 221760_at 0.000988 down MAN1A1 member 1 221761_at 3.40E-05 down ADSS adenylosuccinate synthase 221763_at 2.00E-06 down TRIP8 jumonji domain containing 1C UDP-glucose ceramide 221765_at 2.00E-06 up UGCG glucosyltransferase ELK3, ETS-domain protein (SRF 221773_at 8.00E-06 down ELK3 accessory protein 2) 221775_x_at 2.00E-06 down RPL22 ribosomal protein L22 DnaJ (Hsp40) homolog, subfamily C, 221782_at 0.000362 down ERDJ5 member 10 221787_at 4.80E-05 down PHF10 PHD finger protein 10 221789_x_at 0.000123 down ARHT2 ras homolog gene family, member T2 221790_s_at 0.000399 down ARH LDL receptor adaptor protein 221798_x_at 2.00E-06 down RPS2 ribosomal protein S2

221808_at 0.000706 down RAB9A RAB9A, member RAS oncogene family 221816_s_at 0.000823 up PHF11 PHD finger protein 11

221817_at 0.000162 down DOLPP1 dolichyl pyrophosphate phosphatase 1 221821_s_at 0.000192 down FLJ20436 hypothetical protein FLJ20436 chromosome 20 open reading frame 221827_at 0.00031 up C20ORF18 18 221838_at 3.10E-05 down FLJ14360 hypothetical protein FLJ14360 221841_s_at 1.20E-05 down KLF4 Kruppel-like factor 4 (gut) 221847_at 2.00E-05 down TAS2R14 taste receptor, type 2, member 14 221853_s_at 0.000211 down LOC283820 hypothetical protein LOC283820 221861_at 0.000105 down 221864_at 0.000882 down MGC13024 hypothetical protein MGC13024 221866_at 0.000142 down TFEB transcription factor EB 221878_at 0.000613 down serologically defined breast cancer 221879_at 0.000647 down MGC4809 antigen NY-BR-20 221920_s_at 3.20E-05 up MSCP mitochondrial solute carrier protein nucleophosmin (nucleolar 221923_s_at 1.10E-05 down NPM1 phosphoprotein B23, numatrin) 221931_s_at 2.90E-05 down SEC13L sec13-like protein chromosome 14 open reading frame 221932_s_at 0.000552 down C14ORF87 87 221937_at 6.10E-05 down AP1GBP1 AP1 gamma subunit binding protein 1 221951_at 0.000449 down LOC283232 hypothetical protein LOC283232 221952_x_at 2.00E-06 down KIAA1393 KIAA1393 pyruvate dehydrogenase kinase, 221957_at 0.000501 up PDK3 isoenzyme 3 DKFZP586L 221970_s_at 2.90E-05 down 0724 DKFZP586L0724 protein 221973_at 0.000536 down 221986_s_at 0.00073 down DRE1 DRE1 protein 221989_at 0.000129 down RPL10 ribosomal protein L10 222000_at 1.30E-05 down LOC339448 hypothetical protein LOC339448 mitochondrial translation optimization 1 222014_x_at 0.00043 down MTO1 homolog (S. cerevisiae) solute carrier organic anion transporter 222071_s_at 0.000331 up SLCO4C1 family, member 4C1 wingless-type MMTV integration site 222086_s_at 0.000893 up WNT6 family, member 6 solute carrier family 2 (facilitated 222088_s_at 2.00E-06 up SLC2A14 glucose transporter), member 14 DKFZP434D chromosome 19 open reading frame 222099_s_at 0.000128 down 1335 13 222108_at 0.000947 down AMIGO2 amphoterin induced gene 2 222131_x_at 0.00031 down ARHT2 ras homolog gene family, member T2 222140_s_at 1.70E-05 down SH120 putative G-protein coupled receptor 222141_at 0.000487 up FLJ14360 hypothetical protein FLJ14360 222151_s_at 3.90E-05 down FLJ13386 hypothetical protein FLJ13386 222156_x_at 0.000969 up CPR8 cell cycle progression 8 protein 222164_at 2.00E-06 down retinol dehydrogenase 14 (all-trans and 222203_s_at 2.80E-05 down RDH14 9-cis) 222209_s_at 9.20E-05 down FLJ22104 hypothetical protein FLJ22104 LAG1 longevity assurance homolog 2 222212_s_at 2.00E-06 down LASS2 (S. cerevisiae) 222221_x_at 2.00E-06 up EHD1 EH-domain containing 1 222229_x_at 2.00E-06 down RPL26 ribosomal protein L26 222243_s_at 0.000316 down TOB2 transducer of ERBB2, 2 222266_at 2.50E-05 down C19ORF2 chromosome 19 open reading frame 2 DKFZP547I 222279_at 2.00E-06 down 014 hypothetical protein DKFZp547I014 222297_x_at 2.10E-05 down RPL18 ribosomal protein L18 222303_at 0.000229 up 222307_at 0.000228 down LOC282997 hypothetical protein LOC282997 222326_at 0.00012 up 222328_x_at 0.000788 up 222361_at 0.00094 up 222369_at 8.00E-06 down FLJ13848 hypothetical protein FLJ13848 222385_x_at 0.000636 up SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 222387_s_at 0.000156 down VPS35 vacuolar protein sorting 35 (yeast) 222393_s_at 6.90E-05 down MAK3P Mak3 homolog (S. cerevisiae) 222398_s_at 7.00E-06 down U5-116KD U5 snRNP-specific protein, 116 kD 222400_s_at 2.00E-06 down SIPL SIPL protein 222405_at 0.000389 down HSPC121 butyrate-induced transcript 1 222409_at 7.00E-05 down CORO1C coronin, actin binding protein, 1C

signal sequence receptor, gamma 222412_s_at 3.90E-05 down SSR3 (translocon-associated protein gamma) 222417_s_at 9.00E-06 down SNX5 sorting nexin 5 222422_s_at 0.000429 down NDFIP1 Nedd4 family interacting protein 1 222423_at 0.000115 down NDFIP1 Nedd4 family interacting protein 1 222427_s_at 5.50E-05 down LARS leucyl-tRNA synthetase 222428_s_at 2.00E-06 down LARS leucyl-tRNA synthetase 222430_s_at 5.30E-05 down HGRG8 YTH domain family 2 222431_at 3.20E-05 down SPIN spindlin ubiquitin-conjugating enzyme E2, J1 222435_s_at 8.00E-06 up UBE2J1 (UBC6 homolog, yeast) chromosome 20 open reading frame 222441_x_at 2.00E-06 down C20ORF45 45 222444_at 0.000682 down ALEX3 armadillo repeat containing, X-linked 3

222448_s_at 1.00E-05 down UMP-CMPK UMP-CMP kinase 222453_at 0.000218 down CYBRD1 cytochrome b reductase 1 chromosome 15 open reading frame 222465_at 0.000555 down C15ORF15 15 translocase of outer mitochondrial 222474_s_at 9.00E-06 down TOMM22 membrane 22 homolog (yeast) 222476_at 9.60E-05 down KIAA1194 KIAA1194 222478_at 7.80E-05 down C13ORF9 chromosome 13 open reading frame 9 chromosome 14 open reading frame 222494_at 8.10E-05 down C14ORF116 116 222496_s_at 0.000325 up FLJ20273 RNA-binding protein 222502_s_at 0.000366 up BM-002 ubiquitin-fold modifier 1 chromosome 11 open reading frame 222507_s_at 6.60E-05 down C11ORF15 15 adaptor-related protein complex 3, mu 222516_at 0.000458 down AP3M1 1 subunit 222522_x_at 5.30E-05 down MRPS10 mitochondrial ribosomal protein S10 222526_at 0.000893 down GRIM19 cell death-regulatory protein GRIM19 222528_s_at 0.000357 up MSCP mitochondrial solute carrier protein 222533_at 0.000519 down LOC51185 cereblon

adaptor protein containing pH domain, 222538_s_at 0.000958 down APPL PTB domain and leucine zipper motif 1 222543_at 0.000928 down MGC3067 hypothetical protein MGC3067 mitogen-activated protein kinase 222547_at 0.000958 up MAP4K4 kinase kinase kinase 4 222550_at 2.00E-06 down FLJ10511 armadillo repeat containing protein 222552_at 0.000435 down CGI-141 CGI-141 protein 222553_x_at 4.90E-05 down OXR1 oxidation resistance 1 222557_at 1.70E-05 down STMN3 stathmin-like 3 protein phosphatase 2C, magnesium- 222572_at 2.00E-06 down PPM2C dependent, catalytic subunit 222580_at 3.90E-05 down KIAA1221 KIAA1221 protein 222606_at 0.00058 down FLJ10036 hypothetical protein FLJ10036 222609_s_at 3.00E-05 down CSL4 exosome component 1 222616_s_at 0.000577 down USP16 ubiquitin specific protease 16 222622_at 4.00E-06 down LOC283871 hypothetical protein LOC283871 222623_s_at 1.10E-05 down ANC 2H01 zinc finger protein ANC_2H01 222630_at 4.00E-06 down FLJ12994 hypothetical protein FLJ12994 Shwachman-Bodian-Diamond 222669_s_at 2.00E-06 down SBDS syndrome 222673_x_at 1.30E-05 down FLJ10747 hypothetical protein FLJ10747 222681_at 0.000428 down MDS010 x 010 protein 222692_s_at 8.00E-06 up FAD104 FAD104 222693_at 2.30E-05 up FAD104 FAD104 222697_s_at 9.00E-06 down FLJ11342 hypothetical protein FLJ11342 ADP-ribosylation factor-like 6 222700_at 2.00E-06 down ARL6IP2 interacting protein 2 222715_s_at 3.90E-05 down AP1GBP1 AP1 gamma subunit binding protein 1 222728_s_at 0.000941 down MGC5306 hypothetical protein MGC5306 222756_s_at 0.00012 down ARRB1 arrestin, beta 1 222760_at 8.40E-05 down FLJ14299 hypothetical protein FLJ14299 222763_s_at 0.00094 down FLJ11294 WD repeat domain 33 222794_x_at 9.20E-05 down FLJ10486 PAP associated domain containing 1 222811_at 8.00E-06 down FLJ11171 hypothetical protein FLJ11171 222820_at 5.10E-05 down KIAA1582 KIAA1582 protein 222826_at 0.000596 down PLDN pallidin homolog (mouse) 222838_at 0.000385 up SLAMF7 SLAM family member 7 222848_at 2.00E-06 down FKSG14 leucine zipper protein FKSG14 222881_at 9.00E-05 down HPSE heparanase B-cell CLL/lymphoma 11B (zinc finger 222895_s_at 1.30E-05 down BCL11B protein) 222912_at 0.000109 down ARRB1 arrestin, beta 1 222913_at 9.40E-05 down KLF3 Kruppel-like factor 3 (basic) C-type (calcium dependent, carbohydrate-recognition domain) 222934_s_at 2.00E-06 up CLECSF9 lectin, superfamily member 9 222977_at 0.000547 down SURF4 surfeit 4

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 222985_at 0.000129 down YWHAG gamma polypeptide 222986_s_at 0.000259 up SCOTIN scotin 222987_s_at 9.00E-06 down TMEM9 transmembrane protein 9 222990_at 3.20E-05 down UBQLN1 ubiquilin 1 NADH dehydrogenase (ubiquinone) 1 222992_s_at 4.90E-05 down NDUFB9 beta subcomplex, 9, 22kDa 222996_s_at 0.000589 down HSPC195 CXXC finger 5 222997_s_at 1.10E-05 down MRPS21 mitochondrial ribosomal protein S21 222999_s_at 2.00E-06 down CCNL2 cyclin L2 223001_at 0.000324 down DC2 DC2 protein 223002_s_at 2.00E-06 down XRN2 5'-3' exoribonuclease 2 223004_s_at 1.00E-04 down C3ORF1 chromosome 3 open reading frame 1 223005_s_at 0.000395 up C9ORF5 chromosome 9 open reading frame 5 223006_s_at 0.000303 down C9ORF5 chromosome 9 open reading frame 5 223008_s_at 2.80E-05 down C9ORF5 chromosome 9 open reading frame 5 ovarian carcinoma immunoreactive 223010_s_at 0.000533 down OCIA antigen ovarian carcinoma immunoreactive 223011_s_at 0.000119 down OCIA antigen eukaryotic translation initiation factor 223015_at 2.00E-06 down EIF2A (eIF) 2A 223016_x_at 0.000365 down ZNF265 zinc finger protein 265 cisplatin resistance related protein 223020_at 0.000303 down CRR9 CRR9p 223034_s_at 3.90E-05 down NICE-3 NICE-3 protein N-acetyltransferase 5 (ARD1 homolog, 223040_at 1.10E-05 down NAT5 S. cerevisiae)

223042_s_at 8.60E-05 down HCBP6 hepatitis C virus core-binding protein 6 223043_at 1.10E-05 down LOC51234 hypothetical protein LOC51234 223067_at 0.000712 down HSPC148 hypothetical protein HSPC148 echinoderm microtubule associated 223069_s_at 3.80E-05 up EML4 protein like 4 223071_at 1.70E-05 down HSPC039 HSPC039 protein 223076_s_at 0.000124 down FLJ20303 hypothetical protein FLJ20303 223079_s_at 0.000135 up GLS glutaminase 223086_x_at 0.000877 down MRPL51 mitochondrial ribosomal protein L51 enoyl Coenzyme A hydratase domain 223087_at 0.000171 down ECHDC1 containing 1 223090_x_at 8.00E-06 down VEZATIN transmembrane protein vezatin NOP5/NOP 223096_at 2.00E-06 down 58 nucleolar protein NOP5/NOP58 223098_s_at 0.000181 down LONP peroxisomal lon protease 223104_at 0.000132 down GL009 hypothetical protein GL009 223105_s_at 2.00E-06 down C6ORF53 transmembrane protein 14C 223106_at 2.00E-06 down C6ORF53 transmembrane protein 14C NADH dehydrogenase (ubiquinone) 1 223112_s_at 3.30E-05 down NDUFB10 beta subcomplex, 10, 22kDa 223113_at 2.80E-05 down HSPC196 hypothetical protein HSPC196 223120_at 9.60E-05 down FUCA2 fucosidase, alpha-L- 2, plasma 223124_s_at 2.00E-06 down HT014 HT014 223133_at 1.10E-05 down TMEM14B transmembrane protein 14B 223148_at 0.000884 down PIGS phosphatidylinositol glycan, class S 223156_at 2.00E-06 down MRPS23 mitochondrial ribosomal protein S23 223157_at 2.00E-06 down C4ORF14 chromosome 4 open reading frame 14 223178_s_at 0.000467 down NT5C2L1 5'-nucleotidase, cytosolic II-like 1 223180_s_at 2.00E-06 down HSPC154 HSPC154 protein 223187_s_at 2.00E-06 down LOC51240 chromosome 14 open reading frame 223191_at 3.40E-05 down C14ORF112 112 growth and transformation-dependent 223193_x_at 2.00E-06 down E2IG5 protein DKFZP434L 223204_at 8.90E-05 down 142 hypothetical protein DKFZp434L142 223206_s_at 0.000167 down HSCARG HSCARG protein 223209_s_at 0.000283 down SELS selenoprotein S 223213_s_at 6.30E-05 down ZHX1 zinc fingers and homeoboxes 1 223214_s_at 4.80E-05 down ZHX1 zinc fingers and homeoboxes 1 molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), 223217_s_at 3.10E-05 up MAIL homolog of mouse 223220_s_at 3.20E-05 up BAL B aggressive lymphoma gene 223226_x_at 8.00E-06 down SSBP4 single stranded DNA binding protein 4 223227_at 8.80E-05 down BBS2 Bardet-Biedl syndrome 2 DKFZP761 223228_at 0.000135 down O17121 hypothetical protein DKFZp761O17121 223231_at 0.000518 down CDA11 TatD DNase domain containing 1 13kDa differentiation-associated 223244_s_at 2.00E-06 down DAP13 protein amyotrophic lateral sclerosis 2 (juvenile) chromosome region, 223266_at 0.000126 down ALS2CR2 candidate 2 223269_at 0.000365 down MGC3200 hypothetical protein MGC3200 223270_at 4.90E-05 down HSPC129 hypothetical protein HSPC129 223271_s_at 4.00E-06 down HSPC129 hypothetical protein HSPC129 chromosome 14 open reading frame 223273_at 0.000146 down C14ORF142 142 membrane-spanning 4-domains, 223280_x_at 1.30E-05 down MS4A6A subfamily A, member 6A serologically defined colon cancer 223282_at 8.00E-06 down SDCCAG33 antigen 33 223294_at 0.000163 down MGC874 chromosome X open reading frame 26 223297_at 2.00E-06 down MGC4268 hypothetical protein MGC4268 223298_s_at 0.000102 up NT5C3 5'-nucleotidase, cytosolic III 223300_s_at 1.80E-05 down FLJ23518 hypothetical protein FLJ23518 223301_s_at 0.000811 down FLJ23518 hypothetical protein FLJ23518 solute carrier family 37 (glycerol-3- 223304_at 0.000103 up SLC37A3 phosphate transporter), member 3 ATP-binding cassette, sub-family B 223320_s_at 4.00E-06 down ABCB10 (MDR/TAP), member 10 SGT1, suppressor of G2 allele of SKP1 223329_x_at 9.00E-06 down SUGT1 (S. cerevisiae) DKFZP586C 223334_at 1.10E-05 down 1924 hypothetical protein DKFZp586C1924 223338_s_at 0.000517 down ATPIF1 ATPase inhibitory factor 1 223341_s_at 8.00E-06 down SCOC short coiled-coil protein membrane-spanning 4-domains, 223343_at 1.10E-05 down MS4A7 subfamily A, member 7 membrane-spanning 4-domains, 223344_s_at 3.90E-05 down MS4A7 subfamily A, member 7 223358_s_at 2.00E-05 down PDE7A phosphodiesterase 7A chromosome 6 open reading frame 223361_at 2.00E-06 down C6ORF115 115 223363_at 2.80E-05 down MGC10911 hypothetical protein MGC10911 223384_s_at 0.000459 down TRIM4 tripartite motif-containing 4 sphingosine-1-phosphate phosphatase 223391_at 9.00E-06 down SGPP1 1 polymerase (RNA) I polypeptide B, 223403_s_at 0.000594 down POLR1B 128kDa 223413_s_at 0.000254 down LYAR hypothetical protein FLJ20425 223414_s_at 0.000961 down LYAR hypothetical protein FLJ20425 DKFZP566D 223418_x_at 2.00E-06 down 1346 hypothetical protein DKFZp566D1346 223423_at 0.000178 up GPR160 G protein-coupled receptor 160 223454_at 0.000289 up CXCL16 chemokine (C-X-C motif) ligand 16 223474_at 0.000429 down C14ORF4 chromosome 14 open reading frame 4 223477_s_at 0.00042 down FLJ38663 hypothetical protein FLJ38663 normal mucosa of esophagus specific 223484_at 4.00E-06 up NMES1 1 leucine rich repeat (in FLII) interacting 223492_s_at 7.80E-05 down LRRFIP1 protein 1 223500_at 0.000176 down CPLX1 complexin 1 tumor necrosis factor (ligand) 223501_at 1.80E-05 up TNFSF13B superfamily, member 13b tumor necrosis factor (ligand) 223502_s_at 2.00E-06 up TNFSF13B superfamily, member 13b 223516_s_at 2.00E-06 down C6ORF49 chromosome 6 open reading frame 49 223528_s_at 2.00E-06 down FLJ20859 FLJ20859 gene DKFZP761C 223542_at 0.000357 down 121 ankyrin repeat domain 32 sema domain, transmembrane domain (TM), and cytoplasmic domain, 223567_at 0.000468 up SEMA6B (semaphorin) 6B chromosome 6 open reading frame 223576_at 0.000158 down C6ORF203 203 DKFZP434I 223590_at 0.000712 down 1610 hypothetical protein DKFZp434I1610 223592_s_at 0.00043 down RNF135 ring finger protein 135 223675_s_at 0.000441 down VEZATIN transmembrane protein vezatin 223681_s_at 2.50E-05 down INADL InaD-like protein 223711_s_at 1.10E-05 down THY28 thymocyte protein thy28 223716_s_at 0.000103 down ZNF265 zinc finger protein 265 223767_at 2.00E-06 up GPR84 G protein-coupled receptor 84 223774_at 0.000371 down LOC85028 PNAS-123 223816_at 0.000236 down TSCOT thymic stromal co-transporter 223834_at 0.000398 up PDCD1LG1 programmed cell death 1 ligand 1 223836_at 0.000169 down KSP37 Ksp37 protein membrane-spanning 4-domains, 223922_x_at 1.00E-05 down MS4A6A subfamily A, member 6A dehydrogenase/reductase (SDR family) 223952_x_at 0.00053 up DHRS9 member 9 223960_s_at 0.000517 down C16ORF5 chromosome 16 open reading frame 5 223988_x_at 2.00E-06 down FLJ20859 FLJ20859 gene 223993_s_at 1.80E-05 up HSPC163 HSPC163 protein dehydrogenase/reductase (SDR family) 224009_x_at 0.000789 up DHRS9 member 9 224046_s_at 2.00E-05 up PDE7A phosphodiesterase 7A 224060_s_at 0.000254 down CGI-30 CGI-30 protein 224061_at 0.000344 down INMT indolethylamine N-methyltransferase 224129_s_at 0.000217 down LOC84661 dpy-30-like protein acyl-Coenzyme A dehydrogenase 224160_s_at 1.90E-05 down ACAD9 family, member 9 224173_s_at 0.000455 down MRPL30 mitochondrial ribosomal protein L30 FXYD domain containing ion transport 224252_s_at 2.00E-06 down FXYD5 regulator 5

224281_s_at 1.80E-05 down NEUGRIN mesenchymal stem cell protein DSC92 phosphoglycerate dehydrogenase like 224298_s_at 1.10E-05 down PHGDHL1 1 224302_s_at 0.000311 down MRPS36 mitochondrial ribosomal protein S36 224308_s_at 0.00018 down KIAA1287 KIAA1287 protein SGT1, suppressor of G2 allele of SKP1 224309_s_at 1.70E-05 down SUGT1 (S. cerevisiae) DEAD (Asp-Glu-Ala-Asp) box 224315_at 8.10E-05 down DDX20 polypeptide 20 224330_s_at 2.00E-06 down MRPL27 mitochondrial ribosomal protein L27 224331_s_at 1.10E-05 down MRPL36 mitochondrial ribosomal protein L36 224332_s_at 2.00E-06 down MRPL43 mitochondrial ribosomal protein L43 224341_x_at 0.000428 up TLR4 toll-like receptor 4 growth and transformation-dependent 224345_x_at 2.00E-06 down E2IG5 protein membrane-spanning 4-domains, 224356_x_at 7.00E-06 down MS4A6A subfamily A, member 6A membrane-spanning 4-domains, 224358_s_at 1.10E-05 down MS4A7 subfamily A, member 7 peptidylprolyl isomerase (cyclophilin)- 224364_s_at 1.30E-05 down PPIL3 like 3 RALBP1 associated Eps domain 224366_s_at 4.00E-06 down REPS1 containing 1 224367_at 0.000781 down DJ79P11.1 brain expressed X-linked 2 224374_s_at 0.000829 down EMILIN2 elastin microfibril interfacer 2 microtubule-associated protein 1 light 224378_x_at 0.000362 up MAP1LC3A chain 3 alpha transient receptor potential cation 224412_s_at 0.00053 up TRPM6 channel, subfamily M, member 6 224413_s_at 0.000486 down BLP1 BBP-like protein 1 mitochondrial translation optimization 1 224430_s_at 0.00026 down MTO1 homolog (S. cerevisiae) 224436_s_at 1.70E-05 down NIPSNAP3A nipsnap homolog 3A (C. elegans) 224439_x_at 0.000594 down RNF7 ring finger protein 7 zinc finger, FYVE domain containing 224445_s_at 2.90E-05 down ZFYVE21 21 224450_s_at 1.10E-05 down RIOK1 RIO kinase 1 (yeast) 224452_s_at 2.00E-05 down MGC12966 hypothetical protein MGC12966 calcium binding protein Cab45 224472_x_at 0.000677 down CAB45 precursor 224478_s_at 6.70E-05 down MGC11257 hypothetical protein MGC11257 224481_s_at 4.70E-05 down HECTD1 HECT domain containing 1 224502_s_at 1.10E-05 down KIAA1191 KIAA1191 protein 224511_s_at 0.000628 down TRP14 thioredoxin-like 5 224516_s_at 1.30E-05 down HSPC195 CXXC finger 5 224517_at 0.000273 down MGC13098 hypothetical protein MGC13098 224533_s_at 0.000198 up interferon regulatory factor 2 binding 224569_s_at 0.000129 down IRF2BP2 protein 2 interferon regulatory factor 2 binding 224570_s_at 0.000131 down IRF2BP2 protein 2 interferon regulatory factor 2 binding 224571_at 0.000329 down IRF2BP2 protein 2 224579_at 2.00E-06 down SLC38A1 solute carrier family 38, member 1 224581_s_at 8.00E-06 down chromosome 20 open reading frame 224584_at 4.00E-05 down C20ORF30 30 224591_at 0.000472 down HP1-BP74 HP1-BP74 DKFZP761B 224593_at 2.00E-06 down 128 hypothetical protein DKFZp761B128 224597_at 2.00E-06 down mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- acetylglucosaminyltransferase, 224598_at 0.000399 down MGAT4B isoenzyme B 224602_at 0.000141 up 224605_at 0.000205 up 224607_s_at 9.00E-06 down SRP68 signal recognition particle 68kDa 224610_at 2.00E-06 down RNU22 RNA, U22 small nucleolar dynein, cytoplasmic, light intermediate 224614_at 0.000398 down DNCLI2 polypeptide 2 baculoviral IAP repeat-containing 6 224635_s_at 1.10E-05 down BIRC6 (apollon)

224636_at 2.00E-06 down ZFP91 zinc finger protein 91 homolog (mouse) 224643_at 0.000183 down LOC133619 hypothetical protein MGC12103 224644_at 7.50E-05 down eukaryotic translation initiation factor 224645_at 1.30E-05 down EIF4EBP2 4E binding protein 2 224647_at 5.80E-05 down C10ORF9 chromosome 10 open reading frame 9 224651_at 0.000835 down C10ORF9 chromosome 10 open reading frame 9 eukaryotic translation initiation factor 224653_at 0.000422 down EIF4EBP2 4E binding protein 2 224655_at 0.000982 down AK3L1 adenylate kinase 3 like 1 224660_at 8.10E-05 down MGC14156 hypothetical protein MGC14156 chromosome 10 open reading frame 224664_at 0.000755 down LOC119504 104 224671_at 7.00E-06 down MRPL10 mitochondrial ribosomal protein L10 224675_at 2.00E-06 down MESDC2 mesoderm development candidate 2 224676_at 5.00E-05 down HNLF putative NFkB activating protein HNLF chromosome 11 open reading frame 224677_x_at 2.00E-06 down SELH 31 224680_at 0.000268 down HNLF putative NFkB activating protein HNLF DKFZP434A ankyrin repeat and IBR domain 224687_at 0.000848 down 0225 containing 1 224688_at 7.60E-05 down FLJ10099 hypothetical protein FLJ10099 kinase interacting with leukemia- 224691_at 1.80E-05 down KIS associated gene (stathmin) 224698_at 2.00E-06 down KIAA1228 KIAA1228 protein 224704_at 0.000154 down TNRC6 trinucleotide repeat containing 6 224705_s_at 1.30E-05 down TNRC6 trinucleotide repeat containing 6 224707_at 2.00E-06 up ORF1-FL49 putative nuclear protein ORF1-FL49 224711_at 8.00E-06 down YY1 YY1 transcription factor MKI67 (FHA domain) interacting 224714_at 2.00E-06 down MKI67IP nucleolar phosphoprotein 224718_at 0.000212 down YY1 YY1 transcription factor likely ortholog of mouse gene rich 224719_s_at 2.00E-06 down GRCC10 cluster, C10 gene 224734_at 1.20E-05 down HMGB1 high-mobility group box 1 cell division cycle and apoptosis 224736_at 2.40E-05 down CARP-1 regulator 1 224740_at 2.00E-05 down 224741_x_at 2.00E-06 down GAS5 growth arrest-specific 5 224747_at 2.00E-06 down LOC92912 hypothetical protein LOC92912 224748_at 9.80E-05 down HAN11 WD-repeat protein DKFZP761D 224749_at 0.00016 down 0211 hypothetical protein DKFZp761D0211 224755_at 2.00E-06 down 224759_s_at 2.30E-05 down MGC17943 hypothetical protein MGC17943 224779_s_at 5.10E-05 down FLJ22875 hypothetical protein FLJ22875 224780_at 0.000587 down RBM17 RNA binding motif protein 17 224786_at 7.80E-05 down SCOC short coiled-coil protein 224788_at 6.10E-05 down ARF6 ADP-ribosylation factor 6 224795_x_at 5.80E-05 down 224806_at 0.000151 up ZNF147 tripartite motif-containing 25 224807_at 1.00E-04 up KIAA1533 KIAA1533 224814_at 2.00E-06 down DPP7 dipeptidylpeptidase 7 224815_at 8.40E-05 down C20ORF92 COMM domain containing 7 family with sequence similarity 36, 224820_at 2.00E-06 down LOC116228 member A 224821_at 1.00E-05 down MGC15429 hypothetical protein MGC15429 cleavage and polyadenylation specific 224830_at 1.50E-05 down CPSF5 factor 5, 25 kDa v-ets erythroblastosis virus E26 224833_at 2.00E-06 down ETS1 oncogene homolog 1 (avian) 224837_at 0.000346 down FOXP1 forkhead box P1 224838_at 0.000536 down FOXP1 forkhead box P1 224841_x_at 2.00E-06 down GAS5 growth arrest-specific 5 224844_at 0.000329 down KIAA1458 KIAA1458 protein 224849_at 0.000401 down TTC17 tetratricopeptide repeat domain 17 224857_s_at 0.000266 down MGC9850 hypothetical protein MGC9850 224867_at 2.90E-05 down CG012 hypothetical gene CG012 224871_at 0.000219 down LOC127262 hypothetical protein LOC127262 224875_at 0.000528 down FLJ37562 hypothetical protein FLJ37562 chromosome 9 open reading frame 224879_at 3.70E-05 down MGC4730 123 v-ral simian leukemia viral oncogene 224880_at 1.70E-05 down RALA homolog A (ras related) 224885_s_at 1.10E-05 down KRTCAP2 keratinocyte associated protein 2 224892_at 6.30E-05 down PLDN pallidin homolog (mouse) 224893_at 4.90E-05 down LOC283241 hypothetical protein LOC283241 DKFZP313 224906_at 0.000455 down M0720 transmembrane protein 16F 224912_at 3.90E-05 down TTC7 tetratricopeptide repeat domain 7A 224914_s_at 0.000253 down CIP29 cytokine induced protein 29 kDa 224916_at 1.90E-05 down LOC340061 hypothetical protein LOC340061 224928_at 0.000538 down SET7 SET domain-containing protein 7 224929_at 0.000947 down LOC340061 hypothetical protein LOC340061 224930_x_at 2.00E-06 down RPL7A ribosomal protein L7a 224932_at 3.30E-05 down 224933_s_at 0.000822 down TRIP8 jumonji domain containing 1C eukaryotic translation initiation factor 2, 224935_at 2.80E-05 down EIF2S3 subunit 3 gamma, 52kDa eukaryotic translation initiation factor 2, 224936_at 1.90E-05 down EIF2S3 subunit 3 gamma, 52kDa 224938_at 0.000492 down 182-FIP 82-kD FMRP Interacting Protein 224944_at 6.00E-06 down TMPO thymopoietin 224946_s_at 2.00E-06 down MGC12981 hypothetical protein MGC12981 224948_at 2.00E-06 down MRPS24 mitochondrial ribosomal protein S24 UDP-glucose ceramide 224967_at 2.80E-05 up UGCG glucosyltransferase 224971_at 6.60E-05 down MRPL30 mitochondrial ribosomal protein L30 224981_at 0.000898 down LOC124446 hypothetical protein BC017488 225007_at 2.00E-06 down 225010_at 2.00E-06 down CCDC6 coiled-coil domain containing 6 225014_at 1.30E-05 down 225017_at 0.000184 down FLJ12892 hypothetical protein FLJ12892 225029_at 3.30E-05 down 225032_at 0.00073 up FAD104 FAD104 225036_at 2.00E-06 down 225043_at 2.00E-06 down SLC15A4 solute carrier family 15, member 4 225048_at 2.00E-06 down PHF10 PHD finger protein 10 erythrocyte membrane protein band 225051_at 0.000538 down EPB41 4.1 (elliptocytosis 1, RH-linked) 225052_at 1.80E-05 down MGC14327 hypothetical protein MGC14327 CCR4-NOT transcription complex, 225053_at 8.00E-06 down CNOT7 subunit 7 225055_at 0.000448 down signal-induced proliferation-associated 225056_at 0.000399 up SIPA1L2 1 like 2 225057_at 2.00E-06 down SLC15A4 solute carrier family 15, member 4 rabaptin, RAB GTPase binding effector 225064_at 0.000343 down RABEP1 protein 1 225065_x_at 2.00E-06 down MGC40157 hypothetical protein MGC40157 225076_s_at 0.000215 up KIAA1404 KIAA1404 protein 225083_at 0.00098 down C6ORF51 chromosome 6 open reading frame 51 225086_at 1.10E-05 down FLJ38426 hypothetical protein FLJ38426 rabaptin, RAB GTPase binding effector 225092_at 2.80E-05 down RABEP1 protein 1 225093_at 2.00E-06 down UTRN utrophin (homologous to dystrophin) 225105_at 2.00E-06 down 225113_at 0.000281 down AGPS alkylglycerone phosphate synthase 225114_at 1.30E-05 down AGPS alkylglycerone phosphate synthase 225127_at 6.00E-05 down KIAA1423 KIAA1423 225133_at 5.10E-05 down KLF3 Kruppel-like factor 3 (basic) 225139_at 8.00E-06 down FLJ21918 hypothetical protein FLJ21918 225148_at 0.000621 down MGC52010 hypothetical protein MGC52010 225149_at 6.80E-05 down FLJ11305 hypothetical protein FLJ11305 225153_at 7.20E-05 down EFG1 mitochondrial elongation factor G1 225155_at 2.00E-06 down 225156_at 0.000716 down MGC4549 hypothetical protein MGC4549 225157_at 8.60E-05 down 225158_at 2.00E-06 down EFG1 mitochondrial elongation factor G1 225159_s_at 2.00E-06 down EG1 endothelial-derived gene 1 225161_at 4.00E-05 down EFG1 mitochondrial elongation factor G1 eukaryotic translation initiation factor 2 225164_s_at 1.60E-05 down EIF2AK4 alpha kinase 4 DnaJ (Hsp40) homolog, subfamily C, 225174_at 0.000142 down ERDJ5 member 10 225176_at 3.40E-05 down 225179_at 0.000114 down HIP2 huntingtin interacting protein 2 225182_at 1.10E-05 down C21ORF4 chromosome 21 open reading frame 4 225190_x_at 2.00E-06 down RPL35A ribosomal protein L35a 225191_at 0.000863 down CIRBP cold inducible RNA binding protein pleiotropic regulator 1 (PRL1homolog, 225194_at 0.00016 down PLRG1 Arabidopsis) T-cell activation protein phosphatase 225213_at 9.00E-06 down TA-PP2C 2C 225216_at 5.30E-05 down LOC139231 hypothetical protein BC016683 225220_at 8.00E-06 down SMAD, mothers against DPP homolog 225223_at 0.000123 down MADH5 5 (Drosophila) 225225_at 8.00E-06 down 225230_at 0.000319 down MGC54289 hypothetical protein MGC54289 phosphatidylinositol-3-phosphate 225232_at 2.00E-06 down PIP3AP associated protein 225247_at 0.000265 down C19ORF6 chromosome 19 open reading frame 6

225251_at 0.000622 up RAB24 RAB24, member RAS oncogene family 225253_s_at 3.80E-05 down FLJ12760 hypothetical protein FLJ12760 225260_s_at 2.50E-05 down MRPL32 mitochondrial ribosomal protein L32 225261_x_at 3.70E-05 down TH1L TH1-like (Drosophila) 225262_at 0.000192 up FOSL2 FOS-like antigen 2 225266_at 0.000602 down KIAA0924 KIAA0924 protein spermidine/spermine N1- 225272_at 2.00E-06 down SAT2 acetyltransferase 2 225274_at 4.80E-05 down PCYOX1 prenylcysteine oxidase 1 225283_at 5.50E-05 down LOC91947 arrestin domain containing 4 225290_at 0.000131 down polyribonucleotide 225291_at 0.000141 up PNPT1 nucleotidyltransferase 1 solute carrier family 39 (zinc 225295_at 0.000198 down SLC39A10 transporter), member 10 coiled-coil domain containing 5 (spindle 225297_at 2.80E-05 down CCDC5 associated) 225302_at 0.000346 down FLJ20793 FLJ20793 protein NADH dehydrogenase (ubiquinone) 1 225304_s_at 5.40E-05 down NDUFA11 alpha subcomplex, 11, 14.7kDa 225310_at 2.00E-06 down LOC56267 kynurenine aminotransferase III 225312_at 1.30E-05 down AK000009 COMM domain containing 6 225315_at 0.000719 down MRPL21 mitochondrial ribosomal protein L21 225318_at 0.000174 down KIAA0725 DDHD domain containing 2 paired immunoglobin-like type 2 225321_s_at 0.000597 down PILRB receptor beta 225325_at 3.70E-05 down FLJ20160 FLJ20160 protein 225332_at 0.000128 down chromosome 10 open reading frame 225334_at 0.000444 down C10ORF32 32 splicing factor, arginine/serine-rich 2, 225336_at 0.000998 down SFRS2IP interacting protein 225337_at 0.000358 down ABHD2 abhydrolase domain containing 2 225338_at 0.000473 down FLJ13456 hypothetical protein FLJ13456 membrane component, chromosome 225340_s_at 0.000608 down M11S1 11, surface marker 1 225356_at 4.80E-05 down MGC12538 hypothetical protein MGC12538 225359_at 0.000335 down TIM14 homolog of yeast TIM14 similar to hypothetical protein 225361_x_at 8.00E-06 down LOC159090 MGC17347 similar to hypothetical protein 225362_at 0.000504 down LOC159090 MGC17347 chromosome 20 open reading frame 225376_at 1.10E-05 down C20ORF11 11 225391_at 0.000172 down LOC93622 hypothetical protein BC006130 225398_at 8.00E-06 down FLJ14494 hypothetical protein FLJ14494 225399_at 6.20E-05 down C1ORF19 chromosome 1 open reading frame 19 DKFZP762N 225405_at 2.00E-05 down 1910 hypothetical protein DKFZp762N1910 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- acetylglucosaminyltransferase, 225409_at 2.20E-05 down MGAT4A isoenzyme A 225411_at 5.00E-05 down FLJ14681 hypothetical protein FLJ14681 upregulated during skeletal muscle 225413_at 0.000518 down MGC14697 growth 5 225414_at 5.90E-05 up RNF149 ring finger protein 149 225415_at 0.000101 down BBAP rhysin 2 225419_at 0.000342 down C7ORF11 chromosome 7 open reading frame 11 225425_s_at 8.00E-06 down MRPL41 mitochondrial ribosomal protein L41 general transcription factor IIA, 1, 225433_at 5.60E-05 down GTF2A1 19/37kDa 225441_x_at 0.000468 down MGC14151 hypothetical protein MGC14151 225444_at 0.000768 down N-ethylmaleimide-sensitive factor 225448_at 4.80E-05 down NAPG attachment protein, gamma 225455_at 0.00053 down STAF42 SPT3-associated factor 42 SEC22 vesicle trafficking protein-like 3 225460_at 0.000106 down SEC22L3 (S. cerevisiae) 225462_at 1.80E-05 down MGC13159 hypothetical protein MGC13159 225489_at 2.00E-06 down TMEM18 transmembrane protein 18 225494_at 0.00042 down 225497_at 0.000288 down ATE1 arginyltransferase 1 225512_at 0.000379 down FLJ35036 hypothetical protein FLJ35036 225515_s_at 4.30E-05 down LOC220906 hypothetical protein LOC220906 protein phosphatase 4, regulatory 225519_at 0.000254 up PPP4R2 subunit 2 225523_at 0.000621 down MRPL53 mitochondrial ribosomal protein L53 muskelin 1, intracellular mediator 225526_at 0.000227 down MKLN1 containing kelch motifs 225534_at 9.50E-05 down LOC114926 hypothetical protein BC013035 translocase of inner mitochondrial 225535_s_at 2.00E-06 down TIMM23 membrane 23 homolog (yeast) 225541_at 4.90E-05 down 225546_at 5.70E-05 down EEF2K elongation factor-2 kinase 225547_at 2.00E-06 down 225556_at 1.70E-05 down LOC203547 hypothetical protein LOC203547 225562_at 2.00E-06 down RASA3 RAS p21 protein activator 3 225579_at 2.00E-06 down C2ORF22 chromosome 2 open reading frame 22 RAP2A, member of RAS oncogene 225585_at 0.00023 down RAP2A family 225606_at 2.00E-05 down BCL2L11 BCL2-like 11 (apoptosis facilitator) 225619_at 0.000147 down FLJ30046 hypothetical protein FLJ30046 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3- 225621_at 1.10E-05 down ALG2 mannosyltransferase) myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 225628_s_at 2.90E-05 up MLLT6 Drosophila); translocated to, 6 zinc finger and BTB domain containing 225629_s_at 1.10E-05 down ZBTB4 4 225632_s_at 0.000211 up KIAA1160 KIAA1160 protein signal transducer and activator of 225636_at 0.000392 up STAT2 transcription 2, 113kDa MADS box transcription enhancer factor 2, polypeptide D (myocyte 225641_at 8.00E-06 down MEF2D enhancer factor 2D) ubiquitin-conjugating enzyme E2E 2 225651_at 0.000177 down UBE2E2 (UBC4/5 homolog, yeast) 225657_at 0.000106 down LOC152217 hypothetical protein BC007882 acyl-Coenzyme A binding domain 225663_at 0.000124 down ACBD5 containing 5 interferon (alpha, beta and omega) 225669_at 0.00094 up IFNAR1 receptor 1 DKFZP564 225676_s_at 2.00E-06 down O0463 DKFZP564O0463 protein family with sequence similarity 33, 225684_at 1.70E-05 down LOC348235 member A calmodulin binding transcription 225692_at 0.000128 down CAMTA1 activator 1 calmodulin binding transcription 225693_s_at 0.000303 down CAMTA1 activator 1 225698_at 2.00E-06 down TIGA1 TIGA1 225703_at 0.000626 down KIAA1545 KIAA1545 protein 225704_at 8.20E-05 down KIAA1545 KIAA1545 protein 225708_at 0.00018 down INTERSEX homolog of Drosophila Intersex 225725_at 3.90E-05 down

225739_at 0.000425 down RAB11-FIP4 rab11-family interacting protein 4 225767_at 0.000245 up nuclear receptor subfamily 1, group D, 225768_at 8.00E-06 down NR1D2 member 2 225772_s_at 1.10E-05 down MGC14288 hypothetical protein MGC14288 regulatory solute carrier protein, family 225780_at 4.80E-05 down RSC1A1 1, member 1 225793_at 0.000319 down MGC46719 hypothetical protein MGC46719 hypothetical gene supported by 225794_s_at 1.10E-05 down LOC91689 AL449243 hypothetical gene supported by 225795_at 2.00E-06 down LOC91689 AL449243 heterogeneous nuclear ribonucleoprotein U (scaffold 225805_at 0.000668 down HNRPU attachment factor A) 225808_at 4.00E-06 down LOC124512 hypothetical protein LOC124512 225811_at 0.000198 down 225816_at 2.00E-06 down JADE1 PHD finger protein 17 solute carrier family 12 (sodium/potassium/chloride 225835_at 2.00E-06 down SLC12A2 transporters), member 2 225837_at 5.40E-05 down MGC13204 hypothetical protein MGC13204 polymerase (DNA-directed), epsilon 4 225844_at 2.00E-04 down POLE4 (p12 subunit) 225845_at 1.10E-05 down HSPC063 HSPC063 protein 225878_at 0.000605 up KIF1B kinesin family member 1B DEAD (Asp-Glu-Ala-Asp) box 225886_at 0.000552 down DDX5 polypeptide 5 225899_x_at 0.000114 up LOC349114 hypothetical protein LOC349114 peptidyl-prolyl isomerase G (cyclophilin 225902_at 0.000358 down PPIG G) 225904_at 0.000454 down LOC126731 LOC126731 225908_at 2.00E-05 down LOC285148 hypothetical protein LOC285148 225910_at 0.000422 down LOC284019 hypothetical protein LOC284019 activating transcription factor 7 225917_at 5.50E-05 down ATF7IP interacting protein 225918_at 4.80E-05 down LOC146346 hypothetical protein LOC146346 mitogen-activated protein kinase 225927_at 5.00E-05 down MAP3K1 kinase kinase 1 vesicle transport through interaction 225928_at 3.80E-05 down VTI1B with t-SNAREs homolog 1B (yeast) chromosome 17 open reading frame 225929_s_at 0.00028 up KIAA1554 27 chromosome 17 open reading frame 225931_s_at 0.000112 up KIAA1554 27 225940_at 0.000159 up MGC39820 hypothetical protein MGC39820 225947_at 0.000361 down FLJ22865 myosin head domain containing 1 225969_at 0.000254 down MGC15677 hypothetical protein MGC15677 225971_at 0.000295 down DDHD1 DDHD domain containing 1 similar to RNA polymerase B 225976_at 0.000162 down MGC23908 transcription factor 3 upstream binding transcription factor, 225982_at 1.00E-05 down UBTF RNA polymerase I

likely ortholog of mouse tumor necrosis- 225987_at 1.10E-05 up FLJ23153 alpha-induced adipose-related protein MOB1, Mps One Binder kinase 225997_at 7.60E-05 down MOB4A activator-like 1A (yeast) 226001_at 0.000141 down KLHL5 kelch-like 5 (Drosophila) 226005_at 0.000735 down 226008_at 4.50E-05 down NDNL2 necdin-like 2 226011_at 0.000237 down MGC23918 hypothetical protein MGC23918 226015_at 0.000121 down ZNF325 zinc finger protein 325 CD47 antigen (Rh-related antigen, 226016_at 1.10E-05 down CD47 integrin-associated signal transducer) 226018_at 0.000878 down ELLS1 hypothetical protein Ells1 copper metabolism (Murr1) domain 226024_at 2.00E-05 down C2ORF5 containing 1 226025_at 0.000167 down KIAA0379 ankyrin repeat domain 28 caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down- 226032_at 1.10E-05 down CASP2 regulated 2) mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- acetylglucosaminyltransferase, 226039_at 2.40E-05 down MGAT4A isoenzyme A murine retrovirus integration site 1 226047_at 0.000115 down MRVI1 homolog 226102_at 0.000292 down 226117_at 3.90E-05 up T2BP TRAF2 binding protein 226131_s_at 2.00E-06 down RPS16 ribosomal protein S16 226134_s_at 5.00E-05 down MSI2 musashi homolog 2 (Drosophila) 226136_at 7.90E-05 down HRB2 HIV-1 rev binding protein 2 226137_at 8.10E-05 down ATBF1 AT-binding transcription factor 1 226140_s_at 0.000722 down LOC220213 OTU domain containing 1 226148_at 0.000483 down HSPC063 HSPC063 protein 226150_at 0.000545 down HTPAP HTPAP protein CCR4-NOT transcription complex, 226153_s_at 8.00E-06 down CNOT6L subunit 6-like 226154_at 0.000231 down DNM1L dynamin 1-like v-akt murine thymoma viral oncogene 226156_at 5.10E-05 down AKT2 homolog 2 226165_at 2.00E-06 down 226179_at 2.00E-06 down 226181_at 0.000107 down TUBE1 tubulin, epsilon 1 226188_at 0.000459 down HSPC159 HSPC159 protein 226193_x_at 3.50E-05 down LOC55871 COBW-like protein 226194_at 8.00E-06 down C13ORF8 chromosome 13 open reading frame 8 226198_at 2.00E-06 down TOM1L2 target of myb1-like 2 (chicken) hypothetical protein MGC23937 similar 226199_at 2.90E-05 down MGC23937 to CG4798 226204_at 0.000177 down FLJ21125 hypothetical protein FLJ21125 F-box and leucine-rich repeat protein 226215_s_at 0.000173 down FBXL10 10 226218_at 2.00E-06 down IL7R interleukin 7 receptor 226222_at 0.000273 down KIAA1432 KIAA1432 226236_at 0.000141 down DKFZP547B 226242_at 2.00E-06 down 1713 hypothetical protein DKFZp547B1713 226243_at 0.000286 down 226250_at 0.000416 down 226265_at 2.00E-06 down FLJ21924 hypothetical protein FLJ21924 phosphatidylglycerophosphate 226266_at 0.000103 up PGS1 synthase 226272_at 2.00E-06 down 226275_at 0.000978 up MAD MAX dimerization protein 1 zinc finger and BTB domain containing 226284_at 0.000705 down ZBTB2 2 B double prime 1, subunit of RNA polymerase III transcription initiation 226290_at 2.00E-06 down BDP1 factor IIIB 226296_s_at 8.00E-06 down MRPS15 mitochondrial ribosomal protein S15 chromosome 13 open reading frame 226316_at 0.000442 down C13ORF10 10 transforming growth factor beta 226318_at 9.20E-05 down TBRG1 regulator 1 226319_s_at 2.00E-05 down THOC4 THO complex 4 226332_at 0.000251 down MGC40405 hypothetical protein MGC40405 226337_at 7.40E-05 down FLJ11752 NTKL-binding protein 1 DKFZP434K 226340_x_at 0.000691 down 1323 CXYorf1-related protein 226341_at 0.000104 down fucosyltransferase 11 (alpha (1,3) 226348_at 0.000121 down FUT11 fucosyltransferase) junction-mediating and regulatory 226352_at 5.10E-05 down JMY protein 226356_at 0.000449 down C9ORF54 chromosome 9 open reading frame 54 226361_at 0.00019 down MGC29956 hypothetical protein MGC29956 226364_at 0.000391 up HIP1 huntingtin interacting protein 1 SNF2 histone linker PHD RING 226366_at 8.90E-05 down SHPRH helicase nuclear factor I/C (CCAAT-binding 226377_at 0.000238 down NFIC transcription factor) 226382_at 7.00E-05 down LOC283070 hypothetical protein LOC283070 226383_at 9.10E-05 down FLJ38968 hypothetical protein FLJ38968 226395_at 5.40E-05 down LOC286170 hypothetical protein LOC286170 226399_at 0.000885 down 226401_at 0.000677 up FLJ14464 hypothetical protein FLJ14464 chromosome 6 open reading frame 226412_at 0.000177 down C6ORF111 111 APC11 anaphase promoting complex 226414_s_at 0.000104 down ANAPC11 subunit 11 homolog (yeast) 226416_at 0.000505 up 3'HEXO 3' exoribonuclease splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing 226419_s_at 2.00E-06 down SFRS1 factor) 226425_at 0.000113 down FLJ21069 hypothetical protein FLJ21069 226426_at 0.000161 down ADNP activity-dependent neuroprotector amyotrophic lateral sclerosis 2 (juvenile) chromosome region, 226431_at 3.30E-05 down FLJ38771 candidate 13 Ras association (RalGDS/AF-6) 226436_at 0.000553 down RASSF4 domain family 4 syntrophin, beta 1 (dystrophin- associated protein A1, 59kDa, basic 226438_at 5.10E-05 down SNTB1 component 1) solute carrier family 39 (zinc 226444_at 0.000764 down SLC39A10 transporter), member 10 phosphoinositide-3-kinase adaptor 226459_at 3.80E-05 up PIK3AP1 protein 1 226478_at 0.00022 down

226480_at 8.80E-05 down HSA9761 putative dimethyladenosine transferase 226481_at 2.00E-06 down VPRBP Vpr-binding protein

226496_at 0.000509 down FLJ22611 zinc finger, CCHC domain containing 7 226508_at 3.50E-05 down PHC3 polyhomeotic like 3 (Drosophila) potassium channel tetramerisation 226518_at 0.000129 down KCTD10 domain containing 10 226521_s_at 4.00E-06 down FLJ13614 hypothetical protein FLJ13614 226528_at 0.000568 down 226529_at 3.70E-05 down FLJ11273 hypothetical protein FLJ11273 mannosidase, alpha, class 2A, 226538_at 2.00E-06 down MAN2A1 member 1 226542_at 2.00E-06 up RNF24 ring finger protein 24 226556_at 0.000257 up ubiquitin specific protease 14 (tRNA- 226567_at 2.10E-05 down USP14 guanine transglycosylase) 226568_at 0.000348 down LOC284611 hypothetical protein LOC284611 zinc finger, FYVE domain containing 226581_at 5.00E-05 down ZFYVE20 20 226596_x_at 0.000712 down 226602_s_at 3.20E-05 down BCR breakpoint cluster region 226603_at 0.000137 up FLJ39885 hypothetical protein FLJ39885 226605_at 3.90E-05 down DGKQ diacylglycerol kinase, theta 110kDa 226617_at 3.90E-05 down ARL5 ADP-ribosylation factor-like 5 226620_x_at 4.80E-05 down DAZAP1 DAZ associated protein 1 transforming growth factor, beta 226625_at 5.30E-05 down TGFBR3 receptor III (betaglycan, 300kDa) chromosome 14 open reading frame 226630_at 2.00E-06 down C14ORF106 106 226635_at 0.000217 down 226642_s_at 0.000217 down LOC134492 similar to RIKEN cDNA 2700047N05 226668_at 2.40E-05 down FLJ36175 hypothetical protein FLJ36175 226682_at 2.00E-06 down LOC283666 hypothetical protein LOC283666 226702_at 0.000253 up LOC129607 hypothetical protein LOC129607 226715_at 2.90E-05 down 226721_at 0.000182 down LOC286148 hypothetical protein LOC286148 solute carrier family 27 (fatty acid 226728_at 8.70E-05 down SLC27A1 transporter), member 1 226743_at 1.70E-05 down FLJ34922 hypothetical protein FLJ34922 226747_at 5.00E-05 down KIAA1344 KIAA1344 226748_at 0.000618 down MGC35274 hypothetical protein MGC35274 226758_at 0.000499 down LUC7L2 LUC7-like 2 (S. cerevisiae) 226771_at 2.00E-06 down ATP8B2 ATPase, Class I, type 8B, member 2 226779_at 1.70E-05 down 226785_at 0.000109 down ATP11C ATPase, Class VI, type 11C 226787_at 0.000289 down ZNF18 zinc finger protein 18 (KOX 11) 226801_s_at 3.00E-05 down FLJ12806 hypothetical protein FLJ12806 226816_s_at 1.10E-05 down KIAA1143 KIAA1143 protein 226818_at 1.10E-05 down MPEG1 macrophage expressed gene 1 226820_at 0.000457 down FLJ25476 FLJ25476 protein 226831_at 0.000404 down LOC91137 hypothetical protein BC017169 226832_at 0.000842 down 226835_s_at 0.000283 down TALDO1 transaldolase 1 226841_at 2.00E-06 down MPEG1 macrophage expressed gene 1 226842_at 7.50E-05 down LOC90110 hypothetical protein LOC90110 226845_s_at 7.00E-05 down LOC150678 helicase/primase complex protein 226851_at 0.000115 down LYPLAL1 lysophospholipase-like 1 226867_at 9.60E-05 down C9ORF55 chromosome 9 open reading frame 55 226868_at 0.000907 down LOC283464 hypothetical protein LOC283464 regulatory factor X, 2 (influences HLA 226872_at 0.000122 down RFX2 class II expression) 226876_at 0.000223 down MGC45871 hypothetical protein MGC45871 226879_at 0.000204 down MGC15619 hypothetical protein MGC15619 226880_at 0.000282 down 226883_at 0.000216 down FLJ10572 kelch-like 11 (Drosophila) 226884_at 0.000814 up LRRN1 leucine rich repeat neuronal 1 nuclear factor I/C (CCAAT-binding 226895_at 6.20E-05 down NFIC transcription factor) 226905_at 0.000174 down MGC45871 hypothetical protein MGC45871 actin related protein 2/3 complex, 226915_s_at 0.000259 down ARPC5L subunit 5-like

226917_s_at 0.00014 down ANAPC4 anaphase promoting complex subunit 4 cisplatin resistance related protein 226935_s_at 5.50E-05 down CRR9 CRR9p 226941_at 0.000245 down ATF6 activating transcription factor 6 226951_at 0.000182 down MGC5509 hypothetical protein MGC5509 226962_at 2.60E-05 down FRBZ1 FRBZ1 protein similar to RNA polymerase B 226963_at 3.20E-05 down MGC23908 transcription factor 3 226965_at 2.00E-06 down FLJ34969 hypothetical protein FLJ34969 226968_at 1.50E-05 up KIF1B kinesin family member 1B myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 226981_at 1.10E-05 down MLL Drosophila) 227002_at 9.00E-06 down C9ORF59 chromosome 9 open reading frame 59

227003_at 0.000651 down RAB28 RAB28, member RAS oncogene family 227020_at 2.00E-06 down 227050_at 0.00032 down ODZ3 odd Oz/Ten-m homolog 3 227052_at 0.000654 down 227065_at 9.80E-05 down TRIAD3 TRIAD3 protein mitogen-activated protein kinase 227073_at 0.000856 down MAP3K2 kinase kinase 2 inositol polyphosphate-4-phosphatase, 227087_at 9.00E-05 down INPP4A type I, 107kDa 227095_at 0.000122 down LEPR leptin receptor CCR4-NOT transcription complex, 227119_at 2.70E-05 down CNOT6L subunit 6-like 227129_x_at 0.000458 up 227134_at 0.000272 down JFC1 synaptotagmin-like 1 N-acylsphingosine amidohydrolase 227135_at 2.00E-06 down ASAHL (acid ceramidase)-like 227139_s_at 0.000171 down HPS3 Hermansky-Pudlak syndrome 3 227141_at 0.000284 down LOC127253 hypothetical protein BC009514 227150_at 0.00019 up zinc finger and BTB domain containing 227162_at 0.000936 down ZNF481 26 227189_at 0.000192 down CPNE5 copine V chromosome 21 open reading frame 227199_at 5.40E-05 down C21ORF106 106 227210_at 2.00E-05 down SFMBT2 Scm-like with four mbt domains 2 227228_s_at 8.00E-06 down KIAA1509 KIAA1509 227232_at 1.10E-05 down EVL Enah/Vasp-like DRCTNNB1 227239_at 0.000186 down A down-regulated by Ctnnb1, a kringle containing transmembrane 227250_at 2.00E-06 up KREMEN1 protein 1 227261_at 9.00E-06 down KLF12 Kruppel-like factor 12 227284_at 4.30E-05 down LOC90321 hypothetical protein LOC90321 227286_at 8.00E-05 down FLJ90652 hypothetical protein FLJ90652 227288_at 0.000117 down 227291_s_at 4.00E-06 down 227295_at 0.000637 down IKIP IKK interacting protein serine hydroxymethyltransferase 1 227304_at 0.000475 down SHMT1 (soluble) serine hydroxymethyltransferase 1 227305_s_at 2.40E-05 down SHMT1 (soluble) chromosome 16 open reading frame 227319_at 1.30E-05 down C16ORF44 44 BRCA2 and CDKN1A interacting 227322_s_at 1.10E-05 down BCCIP protein 227351_at 0.000108 down LOC146174 hypothetical protein LOC146174 227353_at 2.00E-06 down EVER2 epidermodysplasia verruciformis 2 227369_at 1.10E-05 down PAI-RBP1 PAI-1 mRNA-binding protein 227385_at 4.90E-05 down GA binding protein transcription factor, 227406_at 0.000806 down GABPB2 beta subunit 2, 47kDa 227407_at 6.40E-05 down FLJ90013 hypothetical protein FLJ90013 227425_at 0.000164 up GA binding protein transcription factor, 227428_at 0.000151 down GABPA alpha subunit 60kDa 227447_at 0.000105 down KIAA0052 KIAA0052 protein 227458_at 0.000459 up PDCD1LG1 programmed cell death 1 ligand 1 227478_at 0.000731 down LOC284262 hypothetical protein LOC284262 227518_at 6.70E-05 down SLC35E1 solute carrier family 35, member E1 227533_at 0.000114 down 227546_x_at 8.20E-05 down AKIP aurora-A kinase interacting protein 227551_at 2.70E-05 down C9ORF77 chromosome 9 open reading frame 77 227552_at 5.80E-05 down 1-Sep septin 1 227567_at 4.00E-05 down DKFZP434B 227580_s_at 0.000528 down 0335 DKFZP434B0335 protein 227592_at 0.000104 down MGC10204 hypothetical protein MGC10204 227593_at 0.000758 down

227609_at 0.000429 up EPSTI1 epithelial stromal interaction 1 (breast) 227616_at 2.00E-05 down BCL9L B-cell CLL/lymphoma 9-like 227618_at 0.000455 down STIP1 homology and U-Box containing 227625_s_at 2.50E-05 down STUB1 protein 1 serum/glucocorticoid regulated kinase- 227627_at 4.90E-05 down SGKL like F-box and leucine-rich repeat protein 227641_at 6.90E-05 down MGC33974 16 227663_at 3.40E-05 down 227668_at 0.000447 down FLJ31528 hypothetical protein FLJ31528 227670_at 0.000464 down ZNF75A zinc finger protein 75a Janus kinase 3 (a protein tyrosine 227677_at 5.40E-05 up JAK3 kinase, leukocyte) RAB40C, member RAS oncogene 227698_s_at 0.000258 down RAB40C family 227706_at 3.90E-05 up SPIR-2 spire homolog 2 (Drosophila) eukaryotic translation elongation factor 227708_at 0.000232 down EEF1A1 1 alpha 1 227712_at 4.80E-05 down DJ122O8.2 hypothetical protein dJ122O8.2 loss of heterozygosity, 12, 227723_at 0.000995 down LOH12CR1 chromosomal region 1 227726_at 0.00053 down MGC2647 ring finger protein 166 227727_at 0.000342 down MGC21621 MAS-related GPR, member F 227749_at 1.30E-05 down 227754_at 0.000209 down USP54 ubiquitin specific protease 54 227755_at 1.10E-05 down LATS, large tumor suppressor, 227772_at 0.000723 down LATS1 homolog 1 (Drosophila) 227792_at 2.90E-05 down SMAD, mothers against DPP homolog 227798_at 1.30E-05 down MADH1 1 (Drosophila) 227799_at 9.00E-06 down MYO1G myosin IG 227801_at 2.90E-05 down TSBF1 tumor suppressor TSBF1 227802_at 6.80E-05 down RIPX rap2 interacting protein x 227836_at 2.20E-05 down MGC14595 hypothetical protein MGC14595 retinitis pigmentosa 9 (autosomal 227852_at 0.000171 down RP9 dominant) 227867_at 2.00E-06 down LOC129293 hypothetical protein LOC129293 227873_at 1.80E-05 down FLJ22625 chromosome 5 open reading frame 14 227917_at 5.00E-05 down 227925_at 1.10E-05 up 227932_at 0.000844 down ARIH2 ariadne homolog 2 (Drosophila) 227948_at 0.000339 up FGD4 FGD1 family, member 4 DKFZP566J 227960_s_at 1.10E-05 down 2046 hypothetical protein DKFZp566J2046 zinc binding alcohol dehydrogenase, 227978_s_at 2.40E-05 down MGC45594 domain containing 2 chromosome 20 open reading frame 227994_x_at 0.00011 down C20ORF149 149 227999_at 0.000283 down LOC170394 PWWP domain containing 2 228005_at 2.80E-05 down ZXDB zinc finger, X-linked, duplicated B 228007_at 1.00E-05 down 228009_x_at 6.60E-05 down ZNRD1 zinc ribbon domain containing, 1 hepatocellular carcinoma related 228024_at 0.000304 down FLJ32642 protein 1 228026_at 0.000422 down FLJ21168 hypothetical protein FLJ21168 228029_at 0.000197 down KIAA1982 KIAA1982 protein 228031_at 0.000129 down LOC149705 hypothetical protein LOC149705 228053_s_at 1.10E-05 down 228055_at 9.00E-06 down 228056_s_at 0.000318 up 228065_at 9.60E-05 down BCL9L B-cell CLL/lymphoma 9-like 228071_at 0.00012 down HIAN7 immune associated nucleotide 228106_at 1.10E-05 down FLJ20280 hypothetical protein FLJ20280 228108_at 8.60E-05 down

228113_at 0.000209 down RAB37 RAB37, member RAS oncogene family 228120_at 0.000115 down 228145_s_at 0.000761 down ZNF398 zinc finger protein 398 228152_s_at 0.000217 up FLJ31033 hypothetical protein FLJ31033 adaptor-related protein complex 4, 228164_at 0.00056 down AP4E1 epsilon 1 subunit DKFZP434I 228171_s_at 0.00023 down 216 DKFZP434I216 protein peroxisomal proliferator-activated 228230_at 0.000468 up PRIC285 receptor A interacting complex 285 228242_at 8.00E-06 down 228258_at 0.000108 down 228273_at 8.00E-06 down FLJ11029 hypothetical protein FLJ11029 228282_at 2.00E-06 down chromosome 20 open reading frame 228291_s_at 2.00E-06 down C20ORF19 19 NADH dehydrogenase (ubiquinone) 1 228301_x_at 4.90E-05 down NDUFB10 beta subcomplex, 10, 22kDa 228309_at 6.70E-05 up C20ORF3 chromosome 20 open reading frame 3 chromosome 11 open reading frame 228332_s_at 2.00E-06 down SELH 31 228333_at 0.000903 down 228336_at 0.000248 down KIAA1935 KIAA1935 protein transducin-like enhancer of split 3 228340_at 0.000552 up TLE3 (E(sp1) homolog, Drosophila) 228341_at 0.000203 down FLJ31265 hypothetical protein FLJ31265 228369_at 0.000473 down TNRC5 trinucleotide repeat containing 5 small nuclear ribonucleoprotein 228370_at 3.30E-05 down SNRPN polypeptide N chromosome 10 open reading frame 228372_at 4.90E-05 down LOC170371 128 228422_at 0.000443 down 228423_at 0.000528 down 228439_at 0.000597 up LOC116071 hypothetical protein BC012330 nuclear factor of activated T-cells, 228442_at 2.80E-05 down NFATC2 cytoplasmic, calcineurin-dependent 2 228444_at 0.000725 down 228456_s_at 0.000347 down LOC149832 hypothetical protein LOC149832 ras responsive element binding protein 228487_s_at 0.000677 down RREB1 1 ubiquitin specific protease 9, Y-linked 228492_at 0.000429 down USP9Y (fat facets-like, Drosophila) 228512_at 2.00E-06 down FLJ20758 FLJ20758 protein 228528_at 0.000236 down 228531_at 0.000495 up FLJ20073 FLJ20073 protein 228543_at 0.000417 down CSRP2BP CSRP2 binding protein 228569_at 0.000184 down PAPOLA poly(A) polymerase alpha membrane-spanning 4-domains, 228592_at 7.70E-05 down MS4A1 subfamily A, member 1 228594_at 0.000115 down FLJ30596 hypothetical protein FLJ30596 228614_at 6.80E-05 down LOC205251 hypothetical protein LOC205251 228617_at 0.000854 up HSXIAPAF1 XIAP associated factor-1 228648_at 7.00E-05 up LRG leucine-rich alpha-2-glycoprotein 1 228650_at 0.000512 down 228654_at 2.00E-06 down LOC139886 hypothetical protein LOC139886 228682_at 0.000318 up MASA E-1 enzyme NADH dehydrogenase (ubiquinone) 1 228690_s_at 7.80E-05 down NDUFA11 alpha subcomplex, 11, 14.7kDa 228710_at 0.000172 down HMT1 hnRNP methyltransferase-like 1 228722_at 0.000882 down HRMT1L1 (S. cerevisiae) serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 228726_at 0.00079 up SERPINB1 1 B-cell CLL/lymphoma 6 (zinc finger 228758_at 2.00E-06 down BCL6 protein 51) Splicing factor, arginine/serine-rich, 228760_at 2.00E-06 down SRP46 46kD 228762_at 2.00E-06 down LFNG lunatic fringe homolog (Drosophila) 228763_at 4.00E-05 down MGC5987 hypothetical protein MGC5987 CD36 antigen (collagen type I receptor, 228766_at 1.00E-05 down CD36 thrombospondin receptor) 228771_at 2.00E-06 down ADRBK2 adrenergic, beta, receptor kinase 2 228793_at 8.00E-06 down TRIP8 jumonji domain containing 1C 228822_s_at 6.80E-05 down USP16 ubiquitin specific protease 16 228841_at 8.00E-06 down LOC90624 hypothetical protein LOC90624 228846_at 2.00E-06 up MAD MAX dimerization protein 1 serine/threonine/tyrosine interacting 228853_at 4.80E-05 down STYX protein 228862_at 0.00094 up FLJ31164 hypothetical protein FLJ31164 228879_at 0.000878 down 228925_at 0.000514 down 228930_at 0.000551 down 228961_at 7.00E-06 down FLJ35954 hypothetical protein FLJ35954 229029_at 9.00E-06 down 229043_at 0.000359 down TRF4-2 PAP associated domain containing 5 229050_s_at 9.00E-05 down MGC16037 hypothetical protein MGC16037 229058_at 2.80E-05 down ANKRD16 ankyrin repeat domain 16 229066_at 6.10E-05 down 229079_at 2.30E-05 up BAT8 HLA-B associated transcript 8 mannan-binding lectin serine protease 229111_at 6.30E-05 down MASP2 2 229119_s_at 0.000232 down ACTB actin, beta chromosome 10 open reading frame 229145_at 6.00E-06 down LOC119504 104 229202_at 5.10E-05 down FLJ11383 hypothetical protein FLJ11383 229220_x_at 5.40E-05 down 229235_at 2.40E-05 down 229269_x_at 2.00E-06 down SSBP4 single stranded DNA binding protein 4 229295_at 0.000444 up LOC150166 hypothetical protein LOC150166 229313_at 0.000594 up LOC203859 transmembrane protein 16E 229317_at 2.70E-05 down nuclear ubiquitous casein kinase and 229353_s_at 2.00E-06 down NUCKS cyclin-dependent kinase substrate human immune associated nucleotide 229367_s_at 2.00E-06 down HIAN2 2 229373_at 5.10E-05 down 229382_at 0.000134 down LOC284465 hypothetical protein LOC284465 glucocorticoid receptor DNA binding 229394_s_at 1.10E-05 down GRLF1 factor 1 229436_x_at 5.30E-05 down C6.1A c6.1A 229439_s_at 0.000556 up FLJ20273 RNA-binding protein CLONE2500 229459_at 0.00057 up 3 TAFA protein 5 229460_at 0.000375 up 229498_at 9.00E-06 down 229521_at 2.50E-05 up FLJ36031 hypothetical protein FLJ36031 229548_at 1.10E-05 up UNC84B unc-84 homolog B (C. elegans) 229563_s_at 2.00E-06 down RPL10A ribosomal protein L10a DnaJ (Hsp40) homolog, subfamily C, 229588_at 0.000575 down ERDJ5 member 10 coiled-coil-helix-coiled-coil-helix 229595_at 0.000321 down CHCHD4 domain containing 4 229614_at 6.60E-05 down LOC162967 hypothetical protein LOC162967 229629_at 9.00E-05 down 229632_s_at 0.000159 down FLJ10569 hypothetical protein FLJ10569 229670_at 0.000955 down purinergic receptor P2Y, G-protein 229686_at 1.80E-05 down P2RY8 coupled, 8 229743_at 2.00E-06 up LOC220929 hypothetical protein LOC220929 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N- acetylglucosamine:polypeptide-N- 229787_s_at 0.00041 down OGT acetylglucosaminyl transferase) 229813_x_at 4.30E-05 down DAZAP1 DAZ associated protein 1 229865_at 7.00E-05 up FAD104 FAD104 229934_at 9.10E-05 up leukocyte immunoglobulin-like receptor, subfamily B (with TM and 229937_x_at 0.000677 down LILRB1 ITIM domains), member 1 229949_at 0.000944 down 229968_at 5.90E-05 up 229969_at 0.000319 down 229980_s_at 2.00E-06 down SNX5 sorting nexin 5 230003_at 0.000608 down O-sialoglycoprotein endopeptidase-like 230032_at 8.00E-06 down OSGEPL1 1 230036_at 0.00021 up FLJ39885 hypothetical protein FLJ39885 chromosome 10 open reading frame 230103_at 0.000379 up C10ORF72 72 230142_s_at 9.00E-06 down CIRBP cold inducible RNA binding protein 230170_at 0.000101 up OSM oncostatin M signal transducer and activator of 230178_s_at 2.80E-05 down STATIP1 transcription 3 interacting protein 1 230213_at 0.00068 down MGC2803 hypothetical protein MGC2803 230230_at 2.00E-06 down 230245_s_at 3.90E-05 down LOC283663 hypothetical protein LOC283663 230298_at 3.70E-05 down 230326_s_at 4.70E-05 down HSPC138 hypothetical protein HSPC138 230331_at 0.000454 up 230350_at 9.80E-05 down 230354_at 0.000526 down 230383_x_at 5.80E-05 down 230387_at 0.000779 down 230391_at 3.00E-05 down 230395_at 9.00E-06 up 230444_at 0.000301 down 230489_at 4.80E-05 down CD5 CD5 antigen (p56-62) 230526_at 0.000468 down KIAA1582 KIAA1582 protein membrane-spanning 4-domains, 230550_at 0.000459 down MS4A6A subfamily A, member 6A 230570_at 0.000525 down 230585_at 1.10E-05 down 230588_s_at 0.000312 down LOC285074 hypothetical protein LOC285074 230741_at 0.000228 down solute carrier family 16 (monocarboxylic acid transporters), 230748_at 0.000753 down SLC16A6 member 6 230866_at 0.000748 down CYSLTR1 cysteinyl leukotriene receptor 1

spastic paraplegia 7, paraplegin (pure 230884_s_at 8.00E-06 down SPG7 and complicated autosomal recessive) 230893_at 0.000379 down LOC134218 hypothetical protein LOC134218 230999_at 3.90E-05 up 231029_at 0.000488 up chromosome 11 open reading frame 231045_x_at 2.00E-06 down SELH 31 231133_at 0.000435 up MGC16372 CG10958-like 231199_at 0.000177 down 231241_at 0.000131 down fetal and adult testis expressed 231573_at 0.000128 up FATE transcript protein nuclear factor of kappa light polypeptide gene enhancer in B-cells 231699_at 9.10E-05 up NFKBIA inhibitor, alpha adaptor-related protein complex 4, beta 231714_s_at 1.80E-05 down AP4B1 1 subunit 231769_at 0.000387 up FBXO6 F-box protein 6 eomesodermin homolog (Xenopus 231776_at 6.00E-05 down EOMES laevis) interleukin-1 receptor-associated 231779_at 0.000985 up IRAK2 kinase 2 231858_x_at 0.000508 up LOC91056 hypothetical protein DKFZp761E198 231886_at 0.000409 down 231896_s_at 0.000374 down DENR density-regulated protein 231929_at 5.10E-05 down 231956_at 0.000376 up KIAA1618 KIAA1618 chromosome 21 open reading frame 231960_at 0.000224 down C21ORF107 107

231973_s_at 2.00E-06 down ANAPC1 anaphase promoting complex subunit 1 231995_at 0.000197 down C9ORF82 chromosome 9 open reading frame 82 232001_at 8.50E-05 down egf-like module containing, mucin-like, 232009_at 1.30E-05 down EMR2 hormone receptor-like 2 232024_at 0.000494 down HIMAP2 immunity associated protein 2 calcium binding protein Cab45 232032_x_at 0.000271 down CAB45 precursor 232068_s_at 4.90E-05 up TLR4 toll-like receptor 4 232077_s_at 0.000429 down MGC10500 hypothetical protein MGC10500 232094_at 0.000106 down FLJ22557 hypothetical protein FLJ22557 232155_at 2.80E-05 up KIAA1618 KIAA1618 232231_at 1.10E-05 down 232323_s_at 8.20E-05 down TTC17 tetratricopeptide repeat domain 17 solute carrier family 30 (zinc 232432_s_at 1.10E-05 down SLC30A5 transporter), member 5 peroxisomal proliferator-activated 232517_s_at 5.40E-05 up PRIC285 receptor A interacting complex 285 peroxisomal proliferator-activated 232518_at 0.000866 up PRIC285 receptor A interacting complex 285

232524_x_at 2.00E-05 down ANAPC4 anaphase promoting complex subunit 4 APG16 autophagy 16-like (S. 232612_s_at 1.30E-05 down APG16L cerevisiae) 232629_at 2.00E-06 up PROK2 prokineticin 2 UDP glycosyltransferase 1 family, 232654_s_at 0.000286 up UGT1A6 polypeptide A6 232681_at 0.000144 down PSIP2 PC4 and SFRS1 interacting protein 1 232706_s_at 3.20E-05 down PP2447 hypothetical protein PP2447 232889_at 0.000545 down LOC153561 hypothetical protein LOC153561 232902_s_at 8.60E-05 down RARSL arginyl-tRNA synthetase-like 232914_s_at 0.00012 down SYTL2 synaptotagmin-like 2 chromosome 20 open reading frame 233001_at 0.000838 down C20ORF136 136 STIP1 homology and U-Box containing 233049_x_at 1.10E-05 down STUB1 protein 1 233072_at 0.000609 up NTNG2 netrin G2 baculoviral IAP repeat-containing 6 233093_s_at 2.00E-06 down BIRC6 (apollon) 233117_at 0.000618 down enoyl Coenzyme A hydratase domain 233124_s_at 0.000916 down ECHDC1 containing 1 233132_at 0.000135 down IGLJ3 immunoglobulin lambda joining 3 233136_at 0.000765 down PABPC5 poly(A) binding protein, cytoplasmic 5 233294_at 0.000126 up 233302_at 2.00E-06 down 233391_at 0.000267 up CDH26 cadherin-like 26 chromosome 6 open reading frame 233438_at 0.000516 up C6ORF162 162 233461_x_at 2.00E-05 down ZNF226 zinc finger protein 226 233467_s_at 4.90E-05 down PHEMX pan-hematopoietic expression 233500_x_at 4.60E-05 down LLT1 lectin-like NK cell receptor CWF19-like 1, cell cycle control (S. 233568_x_at 0.000103 down FLJ10998 pombe) chromosome 20 open reading frame 233571_x_at 0.000501 down C20ORF149 149 signal-induced proliferation-associated 233587_s_at 0.000123 up SIPA1L2 1 like 2 233591_at 1.00E-05 up DKFZP566E 233613_x_at 0.000283 down 144 small fragment nuclease 233625_x_at 4.00E-06 down FLJ20542 hypothetical protein FLJ20542 CDP-diacylglycerol synthase 233630_at 0.00094 down CDS2 (phosphatidate cytidylyltransferase) 2 233825_s_at 1.20E-05 down CD99L2 CD99 antigen-like 2 233864_s_at 0.00011 down VPS35 vacuolar protein sorting 35 (yeast) 233878_s_at 1.00E-05 down XRN2 5'-3' exoribonuclease 2 chromosome 17 open reading frame 233880_at 0.00023 up KIAA1554 27 233955_x_at 3.90E-05 down HSPC195 CXXC finger 5 234107_s_at 9.30E-05 down HARS2 histidyl-tRNA synthetase 2 234119_at 0.000536 up 234192_s_at 8.00E-06 down GKAP42 G kinase anchoring protein 1 debranching enzyme homolog 1 (S. 234295_at 1.10E-05 down DBR1 cerevisiae) 234302_s_at 4.00E-06 down FLJ20308 hypothetical protein FLJ20308 234306_s_at 2.10E-05 up SLAMF7 SLAM family member 7 234311_s_at 0.000278 down LOC85865 hypothetical protein BC004923 glioma tumor suppressor candidate 234339_s_at 2.00E-06 down GLTSCR2 region gene 2

likely ortholog of mouse 234405_s_at 0.00074 down PHAX phosphorylated adaptor for RNA export 234512_x_at 1.10E-05 down RPL7A ribosomal protein L7a kringle containing transmembrane 234843_s_at 0.000621 up KREMEN1 protein 1 234873_x_at 2.00E-06 down RPL7A ribosomal protein L7a 234875_at 2.00E-06 down 234915_s_at 0.000115 down DENR density-regulated protein chromosome 10 open reading frame 234947_s_at 0.000211 down FLJ13188 84 234972_at 0.000131 down LOC339231 hypothetical protein LOC339231 234983_at 3.60E-05 down 234987_at 0.000148 down valosin-containing protein (p97)/p47 234988_at 0.000564 down VCIP135 complex-interacting protein p135 235023_at 2.00E-06 down FLJ20136 vacuolar protein sorting 13C (yeast) 235039_x_at 0.000156 down TGS TUDOR gene similar 235046_at 7.00E-06 down 235052_at 6.80E-05 down FLJ38451 FLJ38451 protein 235054_at 0.000961 up FLJ31265 hypothetical protein FLJ31265 DKFZP761P 235085_at 1.30E-05 down 0423 hypothetical protein DKFZp761P0423 235096_at 0.000934 down LOC123169 senescence downregulated leo1-like mannosidase, alpha, class 2A, 235103_at 8.80E-05 up MAN2A1 member 1 235137_at 0.000285 up LOC285002 hypothetical protein LOC285002 235158_at 4.00E-06 down FLJ14803 hypothetical protein FLJ14803 235174_s_at 7.70E-05 down 235175_at 0.000354 up calmodulin 2 (phosphorylase kinase, 235190_at 0.000245 down CALM2 delta) 235199_at 1.80E-05 down 235230_at 0.000276 down 235252_at 0.000777 down KSR kinase suppressor of ras 235274_at 0.000858 down human immune associated nucleotide 235306_at 9.50E-05 down HIAN6 6 235339_at 0.000394 down SETDB2 SET domain, bifurcated 2 235346_at 4.00E-06 down MGC51029 FUN14 domain containing 1 235384_at 0.000492 down 235385_at 6.70E-05 down FLJ20668 hypothetical protein FLJ20668 235410_at 0.000668 down NPHP3 nephronophthisis 3 (adolescent) 235432_at 2.80E-05 down NPHP3 nephronophthisis 3 (adolescent) DNA cross-link repair 1C (PSO2 235478_at 2.80E-05 down DCLRE1C homolog, S. cerevisiae) 235513_at 0.000142 down 235522_at 3.30E-05 down 235523_at 0.000167 down 235535_x_at 0.000117 down FRG1 FSHD region gene 1 235552_at 0.000665 down KIAA1627 KIAA1627 protein 235568_at 2.00E-06 up LOC199675 hypothetical protein LOC199675 235611_at 5.20E-05 down 235661_at 3.90E-05 down 235670_at 8.60E-05 up 235693_at 0.000144 down inositol polyphosphate-4-phosphatase, 235695_at 7.80E-05 down INPP4A type I, 107kDa

235698_at 0.00026 down ZFP90 zinc finger protein 90 homolog (mouse) DNA2 DNA replication helicase 2-like 235747_at 2.00E-05 down DNA2L (yeast) 235810_at 0.000286 down ZNF21 zinc finger protein 21 (KOX 14) 235816_s_at 0.000193 up 235919_at 4.90E-05 down 235964_x_at 0.000375 down 235974_at 0.000554 up SEC8L1 SEC8-like 1 (S. cerevisiae) 235988_at 0.000218 up GPR110 G protein-coupled receptor 110 236194_at 6.80E-05 down 236198_at 0.000481 down 236265_at 9.00E-06 down SEC22 vesicle trafficking protein-like 3 236268_at 0.000658 down SEC22L3 (S. cerevisiae) 236280_at 2.00E-06 down 236295_s_at 2.00E-06 down NOD3 NOD3 protein 236401_at 1.30E-05 down 236436_at 0.000378 down LOC283130 hypothetical protein LOC283130 236487_at 1.30E-05 down FLJ30655 hypothetical protein FLJ30655 236545_at 0.000561 down 236554_x_at 2.00E-06 down EVER2 epidermodysplasia verruciformis 2 236562_at 0.000806 down ZNF439 zinc finger protein 439 236583_at 3.30E-05 down

236782_at 2.00E-06 down SAMD3 sterile alpha motif domain containing 3 236953_s_at 2.00E-05 down LOC283506 hypothetical protein LOC283506 236995_x_at 0.00073 up TFEC transcription factor EC 237299_at 0.000437 up 237333_at 1.30E-05 down SYNCOILIN intermediate filament protein syncoilin 237340_at 0.000216 up SLC26A8 solute carrier family 26, member 8 237563_s_at 2.00E-05 up 237591_at 2.00E-05 down 237861_at 1.10E-05 up 238002_at 8.00E-06 down GOLPH4 golgi phosphoprotein 4 238034_at 0.000536 down CANX calnexin 238041_at 2.00E-05 down potassium channel tetramerisation 238077_at 1.30E-05 down KCTD6 domain containing 6 mannosidase, alpha, class 2C, 238089_at 6.90E-05 down MAN2C1 member 1 238102_s_at 8.20E-05 down LOC149478 hypothetical protein LOC149478 238142_at 0.000121 down endothelial cell growth factor 1 (platelet- 238327_at 6.80E-05 down ECGF1 derived) 238365_s_at 0.000486 down potassium inwardly-rectifying channel, 238428_at 0.000581 up KCNJ15 subfamily J, member 15 238431_at 1.80E-05 down 238439_at 2.00E-06 up MGC22805 ankyrin repeat domain 22 238461_at 0.000753 up MGC39820 hypothetical protein MGC39820 238465_at 0.000785 down MGC33648 hypothetical protein MGC33648 chromosome 18 open reading frame 238480_at 2.00E-06 down FLJ33761 17 238508_at 4.90E-05 up DRF1 Dbf4-related factor 1 238585_at 0.000119 up FLJ11753 glycosyltransferase-like 1 238668_at 2.00E-05 down 238678_at 0.000282 down 238717_at 1.50E-05 down 238811_at 0.000385 up ATP11B ATPase, Class VI, type 11B 238858_at 0.000856 up T2BP TRAF2 binding protein apolipoprotein B mRNA editing 238860_at 0.000797 down APOBEC2 enzyme, catalytic polypeptide-like 2 238880_at 0.00054 down GTF3A general transcription factor IIIA 238940_at 5.40E-05 down KLF12 Kruppel-like factor 12 238983_at 9.00E-06 up FLJ14001 hypothetical protein FLJ14001 239072_at 0.000654 up synaptosomal-associated protein, 239084_at 0.000248 down SNAP29 29kDa 239122_at 0.00094 down IL24 interleukin 24 239135_at 0.00094 down FLJ11151 hypothetical protein FLJ11151 239151_at 3.90E-05 down 239179_at 0.000958 down 239196_at 2.00E-06 up MGC22805 ankyrin repeat domain 22 239231_at 0.000163 down B-cell CLL/lymphoma 6 (zinc finger 239249_at 9.00E-06 up BCL6 protein 51) 239346_at 0.000757 down 239482_x_at 0.000215 down ZNF15L1 zinc finger protein 15-like 1 (KOX 8) 239598_s_at 0.000852 up FLJ20481 hypothetical protein FLJ20481 239669_at 0.000241 up 239733_at 0.000628 down MGC16186 hypothetical protein MGC16186 239800_at 0.000131 up 239825_at 4.90E-05 down ATF6 activating transcription factor 6 239893_at 0.000367 up

239897_at 1.10E-05 down BCLAF1 BCL2-associated transcription factor 1 239917_at 0.00028 down KIAA0804 KIAA0804 protein 239928_at 0.000943 down FLJ12975 hypothetical protein FLJ12975 240103_at 0.000605 up transient receptor potential cation 240389_at 0.000565 up TRPM6 channel, subfamily M, member 6 240572_s_at 1.10E-05 down LOC374443 CLR pseudogene 240592_at 9.00E-06 down MLR1 transcription factor MLR1 241042_at 0.000971 up 241205_at 0.000169 up 241364_at 3.70E-05 down 241365_at 3.30E-05 down 241370_at 0.000567 down LOC286052 hypothetical protein LOC286052 241435_at 9.20E-05 down 241474_at 0.000429 up 241561_at 0.000345 up 241627_x_at 8.80E-05 down FLJ10357 hypothetical protein FLJ10357 241731_x_at 0.000482 down ZNF440 zinc finger protein 440 calcium/calmodulin-dependent protein 241871_at 0.000148 down CAMK4 kinase IV 241893_at 7.20E-05 down 242017_at 0.000654 down 242020_s_at 0.000165 up ZBP1 Z-DNA binding protein 1 242139_s_at 1.10E-05 down LOC113386 similar to envelope protein 242191_at 1.10E-05 down 242234_at 0.000184 up HSXIAPAF1 XIAP associated factor-1 242263_at 0.000517 down CGI-100 CGI-100 protein 242289_at 1.30E-05 down 242335_at 9.20E-05 down MSCP mitochondrial solute carrier protein 242463_x_at 2.00E-06 down MGC5384 zinc finger protein 611 242625_at 0.000263 up CIG5 viperin 242644_at 2.80E-05 down EVER2 epidermodysplasia verruciformis 2 242669_at 0.000723 down BM-002 ubiquitin-fold modifier 1 242673_at 0.000873 down 242760_x_at 1.80E-05 down PIGB phosphatidylinositol glycan, class B 242851_at 0.000389 down KIAA1919 KIAA1919 DEAD (Asp-Glu-Ala-Asp) box 242961_x_at 0.000237 up RIG-I polypeptide 58 243196_s_at 0.000466 up FLN29 FLN29 gene product MAP kinase interacting 243256_at 0.000458 up MKNK1 serine/threonine kinase 1 243366_s_at 2.00E-06 down 243395_at 0.00058 up 243495_s_at 0.00031 down KIAA0924 KIAA0924 protein WD repeat and FYVE domain 243514_at 6.00E-06 down WDFY2 containing 2 243613_at 0.000567 down MGC24039 hypothetical protein MGC24039 243869_at 0.000481 down solute carrier family 24 (sodium/potassium/calcium 243969_at 0.000971 down SLC24A4 exchanger), member 4 244075_at 0.000472 down 244103_at 2.00E-06 down FLJ35382 hypothetical protein FLJ35382

244124_at 0.000566 up RAB37 RAB37, member RAS oncogene family 244434_at 3.90E-05 down integrin, alpha 4 (antigen CD49D, 244599_at 9.40E-05 down ITGA4 alpha 4 subunit of VLA-4 receptor) 244654_at 2.70E-05 down MYO1G myosin IG cytochrome P450, family 20, subfamily 244732_at 0.000596 up CYP20A1 A, polypeptide 1 244756_at 0.000264 down LOC338692 hypothetical protein LOC338692 244808_at 0.000593 up KIAA1533 KIAA1533 244872_at 0.000385 down SYNCOILIN intermediate filament protein syncoilin CD24 antigen (small cell lung 266_s_at 1.30E-05 up CD24 carcinoma cluster 4 antigen) 32069_at 0.000128 up N4BP1 Nedd4 binding protein 1 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform 32541_at 9.10E-05 down PPP3CC (calcineurin A gamma) 33304_at 0.000879 up ISG20 interferon stimulated gene 20kDa

34210_at 2.00E-06 down CDW52 CDW52 antigen (CAMPATH-1 antigen) 35254_at 1.80E-05 up FLN29 FLN29 gene product 35974_at 2.40E-05 down LRMP lymphoid-restricted membrane protein 36545_s_at 0.000169 down KIAA0542 KIAA0542 gene product DKFZP586P 36552_at 0.000716 down 0123 DKFZP586P0123 protein 36612_at 0.000987 down KIAA0280 KIAA0280 protein ATPase, H+ transporting, lysosomal 36994_at 0.000234 down ATP6V0C 16kDa, V0 subunit c protein phosphatase 1, regulatory 37028_at 0.000219 up PPP1R15A (inhibitor) subunit 15A 37145_at 1.30E-05 down GNLY granulysin protein phosphatase 1F (PP2C domain 37384_at 0.000382 down PPM1F containing) parathyroid hormone-responsive B1 37547_at 0.000226 up B1 gene 37652_at 0.000534 down CABIN1 calcineurin binding protein 1 38069_at 0.000536 down CLCN7 chloride channel 7 38149_at 0.00018 down KIAA0053 Rho GTPase activating protein 25 38241_at 7.70E-05 down BTN3A3 butyrophilin, subfamily 3, member A3 39248_at 2.00E-06 down AQP3 aquaporin 3 39402_at 2.00E-06 up IL1B interleukin 1, beta 39729_at 2.00E-06 down PRDX2 peroxiredoxin 2 SET translocation (myeloid leukemia- 40189_at 2.00E-06 down SET associated) DEAD (Asp-Glu-Ala-Asp) box 40255_at 0.000982 down DDX28 polypeptide 28 41047_at 0.000521 down C9ORF16 chromosome 9 open reading frame 16 41220_at 2.00E-06 down MSF MLL septin-like fusion 41329_at 0.000967 down PACE-1 ezrin-binding partner PACE-1 41386_i_at 0.000485 up KIAA0346 jumonji domain containing 3 43511_s_at 1.30E-05 down chromosome 13 open reading frame 44790_s_at 0.00026 down C13ORF18 18 49111_at 3.60E-05 down Ras association (RalGDS/AF-6) 49306_at 1.50E-05 down RASSF4 domain family 4 50221_at 0.000328 down TFEB transcription factor EB 52940_at 2.00E-06 down SIGIRR single Ig IL-1R-related molecule 56197_at 0.000419 down PLSCR3 phospholipid scramblase 3 56256_at 1.30E-05 down CGI-40 CGI-40 protein family with sequence similarity 26, 57715_at 2.00E-06 down LOC51063 member B 58780_s_at 0.000737 down FLJ10357 hypothetical protein FLJ10357 63825_at 7.70E-05 down ABHD2 abhydrolase domain containing 2 serologically defined breast cancer 64408_s_at 0.000137 down MGC4809 antigen NY-BR-20 64418_at 0.000156 down AP1GBP1 AP1 gamma subunit binding protein 1 64432_at 2.00E-06 down FLJ39616 apoptosis-related protein PNAS-1 64486_at 4.70E-05 down CORO1B coronin, actin binding protein, 1B 65472_at 0.000128 down 65591_at 0.000171 up KIAA1449 WD repeat endosomal protein 65630_at 0.000429 down LOC283232 hypothetical protein LOC283232 rabaptin, RAB GTPase binding effector 74694_s_at 0.000378 down FRA protein 2 91684_g_at 0.000626 up RRP41 exosome component 4 DKFZP762C 91703_at 0.000481 up 186 tangerin Global Functional Analysis of the Down-regulated Genes High Level Function Significance #Genes Genes Protein Synthesis 9.48E-22 - 3.98E-2 83 biosynthesis 9.48E-22 - 9.48E-22 78 CD28, DHPS, EEF1A1 , EEF1A2, EEF2 , EEF2K, EIF2C1, EIF3S1, EIF3S2, EIF3S3, EIF3S4, EIF3S5*, EIF3S7*, EIF3S8*, EIF3S9, EIF4A1*, EIF4B*, EIF4EBP2*, EIF5, EIF5B, FAU*, GPX1, GPX4, GRIM19*, INPP5D, METAP2, MRP63, MRPL20, MRPL27, MRPL3, MRPL32, MRPL34, MRPL36, MRPL43, MRPL51, NACA*, NFX1, PABPC4, PAIP1, PRKCQ, PRKRIR, RARS, RPL14*, RPL15*, RPL18A*, RPL19*, RPL23A*, RPL26, RPL3*, RPL31, RPL32, RPL4*, RPL41, RPL6*, RPL7*, RPL8, RPL9*, RPLP0*, RPLP1, RPLP2, RPS10*, RPS11*, RPS12, RPS14*, RPS15, RPS18, RPS2*, RPS20*, RPS21, RPS24*, RPS28*, RPS3, RPS5*, RPS6*, RPS7*, SCYE1*, biosynthesis of protein 9.48E-22 78 TP53, TXNRD1 synthesis 8.38E-19 - 8.38E-19 83 AKT1, CD28, CDKN1B, DHPS, EEF1A1 , EEF1A2, EEF2 , EEF2K, EIF1A, EIF2C1, EIF3S1, EIF3S2, EIF3S3, EIF3S4, EIF3S5*, EIF3S7*, EIF3S8*, EIF3S9, EIF4A1*, EIF4B*, EIF4EBP2*, EIF5, EIF5B, FAU*, GPX1, GPX4, GRIM19*, INPP5D, LCK*, METAP2, MRP63, MRPL20, MRPL27, MRPL3, MRPL32, MRPL34, MRPL36, MRPL43, MRPL51, MYC, NACA*, NFX1, PABPC4, PAIP1, PRKCQ, PRKRIR, RARS, RPL14*, RPL15*, RPL18A*, RPL19*, RPL23A*, RPL26, RPL3*, RPL31, RPL32, RPL4*, RPL41, RPL6*, RPL7*, RPL8, RPL9*, RPLP0*, RPLP1, RPLP2, RPS10*, RPS11*, RPS12, RPS14*, RPS15, RPS18, RPS2*, RPS20*, RPS21, RPS24*, RPS28*, RPS3, RPS5*, synthesis of protein 8.38E-19 83 RPS6*, RPS7*, SCYE1*, TP53, TXNRD1 translation 5.40E-6 - 2.40E-2 29 EIF2C1, EIF3S1, EIF3S2, EIF3S3, EIF3S4, EIF3S5*, EIF3S7*, initiation of translation 0.0000054 13 EIF3S8*, EIF3S9, EIF4B*, EIF4EBP2*, EIF5, TP53 EEF1A1*, EEF1A2, EEF2*, EEF2K, EIF2C1, EIF3S1, EIF3S2, EIF3S3, EIF3S4, EIF3S5*, EIF3S7*, EIF3S8*, EIF3S9, EIF4A1*, EIF4B*, EIF4EBP2*, EIF5, EIF5B, GPX1, GPX4, METAP2, NACA*, PAIP1, translation 0.000013 29 PRKRIR, RARS, RPS6*, SCYE1*, TP53, TXNRD1 translational elongation 0.024 6 EEF1A2, EEF2*, EEF2K, GPX1, GPX4, TXNRD1 elongation 1.64E-3 - 1.64E-3 3 elongation of protein 0.00164 3 EEF1A1*, EEF2*, RPS6* incorporation 3.98E-2 - 3.98E-2 3 incorporation of selenocysteine 0.0398 3 GPX1, GPX4, TXNRD1 RNA Post-Transcriptional Mo1.89E-14 - 4.39E-2 60 processing 1.89E-14 - 2.05E-5 55 ARL6IP4, C15ORF12, CPSF5 , DBR1, DDX20, DDX41, DICER1, DKC1, E1B-AP5, FBL, FUSIP1*, GRSF1*, HCFC1, HNRPA0, HNRPD*, HNRPDL*, HNRPH1*, HNRPR*, HNRPU, LSM1, LUC7A, NCBP2*, NOLC1, NOP5/NOP58, PABPC1*, PABPC4, PABPN1, PLRG1, POP5, PPIG, PRPF4B*, PRPF8*, RNMT, RNPS1*, SAP18, SF3A3, SFRS1, SFRS11*, SFRS2*, SFRS5*, SFRS6, SFRS7*, SIP1, SNRP70, SNRPA, SNRPA1, SNRPB2, SNRPD2, SNRPD3, SNRPG, processing of RNA 1.89E-14 55 SNRPN*, SYNCRIP*, U5-116KD, U5-200KD*, ZNF265*

CPSF5*, DBR1, DDX20, FUSIP1*, GRSF1*, HCFC1, HNRPA0, HNRPR*, NCBP2*, PABPC1*, PABPN1, PLRG1, PRPF8*, RNMT, processing of mRNA 0.0000205 22 SFRS1, SFRS2*, SFRS5*, SFRS6, SIP1, SNRP70, SNRPA, SNRPD2 modification 2.02E-14 - 3.52E-6 60 APOBEC2, ARL6IP4, C15ORF12, CPSF5 , DBR1, DDX20, DDX41, DICER1, DKC1, E1B-AP5, EIF4A1*, EIF4B*, FBL, FUSIP1*, GRSF1*, HCFC1, HNRPA0, HNRPD*, HNRPDL*, HNRPH1*, HNRPR*, HNRPU, LSM1, LUC7A, NCBP2*, NOLC1, NOP5/NOP58, PABPC1*, PABPC4, PABPN1, PLRG1, POP5, PPIG, PRPF4B*, PRPF8*, RARS, RNMT, RNPS1*, SAP18, SCYE1*, SF3A3, SFRS1, SFRS11*, SFRS2*, SFRS5*, SFRS6, SFRS7*, SIP1, SNRP70, SNRPA, SNRPA1, SNRPB2, SNRPD2, SNRPD3, SNRPG, SNRPN*, SYNCRIP*, U5- modification of RNA 2.02E-14 60 116KD, U5-200KD*, ZNF265* APOBEC2, CPSF5*, DBR1, DDX20, EIF4A1*, EIF4B*, FUSIP1*, GRSF1*, HCFC1, HNRPA0, HNRPR*, NCBP2*, PABPC1*, PABPN1, PLRG1, PRPF8*, RNMT, SFRS1, SFRS2*, SFRS5*, SFRS6, SIP1, modification of mRNA 0.00000352 25 SNRP70, SNRPA, SNRPD2 splicing 6.51E-9 - 1.82E-2 30 ARL6IP4, DBR1, DDX20, FUSIP1*, HCFC1, LSM1, LUC7A, PLRG1, PPIG, PRPF4B*, RNPS1*, SF3A3, SFRS1, SFRS11*, SFRS2*, SFRS5*, SFRS6, SFRS7*, SIP1, SNRP70, SNRPA1, SNRPB2, SNRPD2, SNRPD3, SNRPG, SNRPN*, SYNCRIP*, U5-116KD, U5- splicing of RNA 6.51E-09 30 200KD*, ZNF265* DBR1, DDX20, FUSIP1*, HCFC1, PLRG1, SFRS1, SFRS2*, SFRS5*, splicing of mRNA 0.00429 11 SFRS6, SIP1, SNRPD2 spliceosome assembly 0.0182 5 FUSIP1*, SFRS5*, SFRS6, SIP1, SNRPD2 polyadenylation 4.39E-2 - 4.39E-2 4 polyadenylation of mRNA 0.0439 4 GRSF1*, PABPC1*, PABPN1, SNRPA Immune Response 2.27E-5 - 4.60E-2 148 immune response 2.27E-5 - 4.60E-2 143 antigen presentation, exogenous peptide antigen 0.0000227 5 HLA-DMA, HLA-DQA1, HLA-DQB1*, HLA-DRA*, HLA-DRB1 antigen presentation, exogenous antigen via CD74, HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1*, HLA-DRA*, MHC class II 0.000144 7 HLA-DRB1 CD1D, CD74, HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1*, HLA- antigen presentation 0.000196 8 DRA*, HLA-DRB1 antigen processing 0.000932 5 CD74, HLA-DMA, HLA-DMB, IFI30, IGHM antigen processing, exogenous antigen via MHC class II 0.00502 4 CD74, HLA-DMA, HLA-DMB, IFI30 ADA, AIF1*, AIP, ANXA11, APG16L, APOL3, ARF6, BCL2, BCL6*, BCR*, BMI1, C1QBP*, CALR, CASP8*, CBLB, CCL5*, CCND2, CCR3, CCR7, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CNIH, CORO1C, CSF1R, CTSC, CTSW, CX3CR1, CXCR3, CXCR4*, CYSLTR1, DOK2, EBI2, ELMO1, ETS1, FCER1A, FLT3LG, FYN*, GATA3*, GNLY*, GP1BA, GPI, GPR44, GPX4, GZMA, HGRG8*, HLA- DMA, HLA-DMB, HLA-DQA1, HLA-DQB1*, HLA-DRA*, HLA-DRB1, HMGB1*, ICSBP1, ID2*, IFI30, IGHM, IGKC, IKBKAP, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGA4*, ITGAL, ITGB1*, ITGB5, KLRB1, KLRC1, KLRD1, KLRF1, KLRK1, KSR, LAT*, LCK*, LEF1*, LGALS9, LILRB1, LLT1*, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MME*, MS4A1*, MYBL1, MYC, NAP1L4, NCK1, NFATC2, NFX1, PECAM1*, PHEMX, PIK3R1*, PLA2G7, PPIA*, PRF1, PRKCB1, PRKCQ, PSMB10, PSME2, PTGER4, PTPRCAP, RASGRP1, RBPSUH*, RPS19*, SCYE1*, SECTM1, SH2D1A*, SIAT1, SOD1, STAT4, TNFRSF25*, TOSO*, TP53, TPT1, TRA1, TRA@, immune response 0.0126 143 TRD@*, TRIM, XCL1, YY1*, ZAP70 immune response of T lymphocytes 0.046 6 BCR*, CD28, CD3Z, IL15, NFATC2, PSME2 proliferation 1.16E-4 - 3.39E-2 69 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, proliferation of MAD1L1, MAP3K2, MIF, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, mononuclear PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, STAT4, leukocytes 0.000116 65 TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, proliferation of PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, leukocytes 0.000196 66 STAT4, TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GSTP1, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAFG, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, proliferation of SECTM1, SIAT1, SLC29A1, STAT4, TP53, TPT1, TRA1, TRA@, lymphatic system cells 0.000218 69 TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, proliferation of PTPRCAP, RASGRP1, SECTM1, SIAT1, STAT4, TP53, TPT1, TRA1, lymphocytes 0.000285 63 TRA@, TRD@*, XCL1, ZAP70 BCL2, C1QBP*, CBLB, CD2, CD28, CD36*, CD3E, CD3Z, CD47, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, HLA-DRB1, IGHM, IL15, IL2RB, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LILRB1, MAD1L1, MAP3K2, MIF, MYC, NCK1, proliferation of T PECAM1*, PHEMX, PRKCQ, PTPRCAP, RASGRP1, SECTM1, lymphocytes 0.00197 46 STAT4, TP53, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCR*, CCND2, CD244, CD3E, CD3Z, CD86, CD8A, FYN*, IGHM, proliferation of B IGKC, IL15, IL7R*, INPP5D, LEF1*, LNK, LPIN1, LY86, MS4A1*, lymphocytes 0.00355 24 MYC, PECAM1*, PIK3R1*, PTPRCAP, SIAT1, TPT1 proliferation of splenocytes 0.0139 7 CD3Z, CDKN1B, FLT3LG, IGHM, IL15, LNK, TP53 proliferation of bone BCR*, CCND2, CDKN1B, CSF1R, FLT3LG, GSTP1, LNK, MAD1L1, marrow cells 0.0339 10 MAFG, MLL* activation 3.87E-4 - 3.85E-2 90 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, activation of SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, TRA@, lymphocytes 0.000387 86 TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GZMA, HLA-DMA, HLA-DQA1, HLA- DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, activation of PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, mononuclear SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, leukocytes 0.000435 87 TRA@, TRD@*, XCL1, ZAP70 BCL2, BCL6*, C1QBP*, CASP8*, CBLB, CCL5*, CD1D, CD2, CD28, CD36*, CD3E, CD3Z, CD47, CD7*, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, GATA3*, HLA-DMA, HLA- DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IL15, IL2RB, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, MAD1L1, MAF, MAP3K2, MIF, MYC, NCK1, NFATC2, activation of T PECAM1*, PHEMX, PRF1, PRKCQ, PTPRCAP, RASGRP1, SECTM1, lymphocytes 0.000465 66 SH2D1A*, STAT4, TP53, TRA1, TRA@, TRD@*, XCL1, ZAP70 activation of thymocytes 0.00189 5 CD2, CD3E, CD3Z, FYN*, LAT* AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, activation of lymphatic RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, system cells 0.00289 90 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, activation of leukocytes 0.0041 90 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 AIP, BCR*, CCND2, CD244, CD3E, CD3Z, CD74, CD79B, CD86, CD8A, FYN*, IGHM, IGKC, IL15, IL2RB, IL7R*, INPP5D, LEF1*, LNK, activation of B LPIN1, LY86, MS4A1*, MYC, PECAM1*, PIK3R1*, PTPRCAP, lymphocytes 0.0175 29 RBPSUH*, SIAT1, TPT1 activation of natural killer cells 0.0345 9 CCL5*, CD2, CD244, CD81, FLT3LG, IL15, ITGAL, KLRC1, KLRD1 activation of helper T lymphocytes 0.0385 2 CD28, CD3Z clustering 5.97E-3 - 5.97E-3 3 clustering of Langerhans cells 0.00597 3 CDH1, ITGAL, PECAM1* generation 1.04E-2 - 3.98E-2 6 generation of lymphocytes 0.0104 6 CD3Z, CD5, CD86, FLT3LG, IL15, IL7R* generation of thymocytes 0.0139 2 CD3Z, CD5 generation of T lymphocytes 0.0398 3 CD3Z, CD5, CD86 selection 1.07E-2 - 1.07E-2 7 selection of T lymphocytes 0.0107 7 CD1D, CD28, CD74, HLA-DMA, IL15, MAD1L1, TNFRSF25* contact sensitivity 1.39E-2 - 1.39E-2 2 initiation of contact sensitivity 0.0139 2 IGHM, IGKC aggregation 3.03E-2 - 3.03E-2 6 aggregation of mononuclear leukocytes 0.0303 6 CDH1, IL15, ITGAL, LCK*, PECAM1*, PTGER4 production 3.85E-2 - 3.98E-2 3 production of T lymphocytes 0.0385 2 FYN*, ITGA4* production of lymphocytes 0.0398 3 FYN*, IL2RB, ITGA4* Cellular Growth and Prolifera1.16E-4 - 3.98E-2 98 proliferation 1.16E-4 - 3.39E-2 69 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, proliferation of MAD1L1, MAP3K2, MIF, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, mononuclear PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, STAT4, leukocytes 0.000116 65 TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, proliferation of PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, leukocytes 0.000196 66 STAT4, TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GSTP1, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAFG, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, proliferation of SECTM1, SIAT1, SLC29A1, STAT4, TP53, TPT1, TRA1, TRA@, lymphatic system cells 0.000218 69 TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, proliferation of PTPRCAP, RASGRP1, SECTM1, SIAT1, STAT4, TP53, TPT1, TRA1, lymphocytes 0.000285 63 TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GSTP1, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, proliferation of blood SECTM1, SIAT1, SLC29A1, STAT4, TP53, TPT1, TRA1, TRA@, cells 0.00133 68 TRD@*, XCL1, ZAP70 BCL2, C1QBP*, CBLB, CD2, CD28, CD36*, CD3E, CD3Z, CD47, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, HLA-DRB1, IGHM, IL15, IL2RB, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LILRB1, MAD1L1, MAP3K2, MIF, MYC, NCK1, proliferation of T PECAM1*, PHEMX, PRKCQ, PTPRCAP, RASGRP1, SECTM1, lymphocytes 0.00197 46 STAT4, TP53, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCR*, CCND2, CD244, CD3E, CD3Z, CD86, CD8A, FYN*, IGHM, proliferation of B IGKC, IL15, IL7R*, INPP5D, LEF1*, LNK, LPIN1, LY86, MS4A1*, lymphocytes 0.00355 24 MYC, PECAM1*, PIK3R1*, PTPRCAP, SIAT1, TPT1 proliferation of splenocytes 0.0139 7 CD3Z, CDKN1B, FLT3LG, IGHM, IL15, LNK, TP53 proliferation of bone BCR*, CCND2, CDKN1B, CSF1R, FLT3LG, GSTP1, LNK, MAD1L1, marrow cells 0.0339 10 MAFG, MLL* growth 2.14E-3 - 3.85E-2 36 growth of lymphoma CALR, CTCF, IGFBP7, IGHM, IL15, MLL*, MYBL1, SFRS1, SFRS2*, cell lines 0.00214 11 SFRS5*, TP53 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, CSF1R, FLT3LG, ICSBP1, IGHM, IL15, IL2RB, IL7R*, MAD1L1, MYBL1, MYC, NFATC2, growth of leukocytes 0.00471 19 TP53, ZAP70 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, CSF1R, FLT3LG, growth of lymphatic ICSBP1, IGHM, IL15, IL2RB, IL7R*, INPP4A*, MAD1L1, MYBL1, system cells 0.00572 21 MYC, NFATC2, NPM1*, TP53, ZAP70 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, IGHM, IL15, IL2RB, growth of lymphocytes 0.00857 16 IL7R*, MAD1L1, MYBL1, MYC, NFATC2, TP53, ZAP70 growth of stomach cancer cell lines 0.0139 2 F2RL1, RUNX3* growth of B lymphocytes 0.0344 8 BCL2, BCR*, IGHM, IL2RB, MYBL1, MYC, NFATC2, TP53 growth of kidney cell lines 0.0344 8 CDK2AP1, CES2, CSF1R, F2RL1, ITGB1*, PNN, RASSF1, TP53 arrest in growth of colon cell lines 0.0385 2 KLF4, TP53 arrest in growth of colorectal cancer cell lines 0.0385 2 KLF4, TP53 arrest in growth of vascular smooth muscle cells 0.0385 2 KLF4, TP53 production 5.02E-3 - 3.98E-2 7 production of germ cells 0.00502 4 HSF2, SLC12A2, STYX, UBE3A production of male germ cells 0.0249 3 SLC12A2, STYX, UBE3A production of T lymphocytes 0.0385 2 FYN*, ITGA4* production of lymphocytes 0.0398 3 FYN*, IL2RB, ITGA4* generation 1.04E-2 - 3.98E-2 6 generation of lymphocytes 0.0104 6 CD3Z, CD5, CD86, FLT3LG, IL15, IL7R* generation of thymocytes 0.0139 2 CD3Z, CD5 generation of T lymphocytes 0.0398 3 CD3Z, CD5, CD86 colony formation 1.36E-2 - 3.98E-2 11 colony formation of lymphoma cell lines 0.0136 3 BACH2, CTCF, IGFBP7 colony formation of cell lines 0.0249 3 DCK, MYC, PIK3R1* colony formation of liver cell lines 0.0385 2 DNCH1, UBTF colony formation of bone cancer cell lines 0.0398 3 CNOT7*, MAD1L1, TP53 formation 1.36E-2 - 1.36E-2 3 formation of blood platelets 0.0136 3 CASP8*, MAFG, PECAM1* Immune and Lymphatic Syst1.16E-4 - 4.78E-2 106 proliferation 1.16E-4 - 3.39E-2 69 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, proliferation of MAD1L1, MAP3K2, MIF, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, mononuclear PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, STAT4, leukocytes 0.000116 65 TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, proliferation of PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, leukocytes 0.000196 66 STAT4, TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GSTP1, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAFG, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, proliferation of SECTM1, SIAT1, SLC29A1, STAT4, TP53, TPT1, TRA1, TRA@, lymphatic system cells 0.000218 69 TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, proliferation of PTPRCAP, RASGRP1, SECTM1, SIAT1, STAT4, TP53, TPT1, TRA1, lymphocytes 0.000285 63 TRA@, TRD@*, XCL1, ZAP70 BCL2, C1QBP*, CBLB, CD2, CD28, CD36*, CD3E, CD3Z, CD47, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, HLA-DRB1, IGHM, IL15, IL2RB, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LILRB1, MAD1L1, MAP3K2, MIF, MYC, NCK1, proliferation of T PECAM1*, PHEMX, PRKCQ, PTPRCAP, RASGRP1, SECTM1, lymphocytes 0.00197 46 STAT4, TP53, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCR*, CCND2, CD244, CD3E, CD3Z, CD86, CD8A, FYN*, IGHM, proliferation of B IGKC, IL15, IL7R*, INPP5D, LEF1*, LNK, LPIN1, LY86, MS4A1*, lymphocytes 0.00355 24 MYC, PECAM1*, PIK3R1*, PTPRCAP, SIAT1, TPT1 proliferation of splenocytes 0.0139 7 CD3Z, CDKN1B, FLT3LG, IGHM, IL15, LNK, TP53 proliferation of bone BCR*, CCND2, CDKN1B, CSF1R, FLT3LG, GSTP1, LNK, MAD1L1, marrow cells 0.0339 10 MAFG, MLL* activation 3.87E-4 - 3.85E-2 90 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, activation of SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, TRA@, lymphocytes 0.000387 86 TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GZMA, HLA-DMA, HLA-DQA1, HLA- DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, activation of PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, mononuclear SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, leukocytes 0.000435 87 TRA@, TRD@*, XCL1, ZAP70 BCL2, BCL6*, C1QBP*, CASP8*, CBLB, CCL5*, CD1D, CD2, CD28, CD36*, CD3E, CD3Z, CD47, CD7*, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, GATA3*, HLA-DMA, HLA- DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IL15, IL2RB, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, MAD1L1, MAF, MAP3K2, MIF, MYC, NCK1, NFATC2, activation of T PECAM1*, PHEMX, PRF1, PRKCQ, PTPRCAP, RASGRP1, SECTM1, lymphocytes 0.000465 66 SH2D1A*, STAT4, TP53, TRA1, TRA@, TRD@*, XCL1, ZAP70 activation of thymocytes 0.00189 5 CD2, CD3E, CD3Z, FYN*, LAT* AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, activation of lymphatic RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, system cells 0.00289 90 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, activation of leukocytes 0.0041 90 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 AIP, BCR*, CCND2, CD244, CD3E, CD3Z, CD74, CD79B, CD86, CD8A, FYN*, IGHM, IGKC, IL15, IL2RB, IL7R*, INPP5D, LEF1*, LNK, activation of B LPIN1, LY86, MS4A1*, MYC, PECAM1*, PIK3R1*, PTPRCAP, lymphocytes 0.0175 29 RBPSUH*, SIAT1, TPT1 activation of natural killer cells 0.0345 9 CCL5*, CD2, CD244, CD81, FLT3LG, IL15, ITGAL, KLRC1, KLRD1 activation of helper T lymphocytes 0.0385 2 CD28, CD3Z development 1.12E-3 - 3.98E-2 30 ADA, BCL2, BMI1, CD1D, CD28, CD3D, CD3E, CD3Z, CD74, development of T CDKN1B, ETS1, FYN*, GATA3*, IL2RB, IL7R*, ITGA4*, LAT*, LCK*, lymphocytes 0.00112 23 SATB1, STAT4, TP53, TRA@, ZAP70 arrest in development of T lymphocytes 0.00164 3 CD3D, FYN*, LCK* ADA, BCL2, BMI1, CD1D, CD28, CD3D, CD3E, CD3Z, CD74, CDKN1B, CXCR4*, ETS1, FLT3LG, FYN*, GATA3*, IGHM, IL15, development of IL2RB, IL7R*, INPP5D, ITGA4*, LAT*, LCK*, LFNG, PIK3R1*, SATB1, lymphocytes 0.00194 30 STAT4, TP53, TRA@, ZAP70 development of BCL2, CD3D, CD3E, CD74, CDKN1B, IL2RB, LAT*, SATB1, TP53, thymocytes 0.00788 11 TRA@, ZAP70 arrest in development of alpha-beta T lymphocytes 0.0139 2 FYN*, LCK* development of natural killer T lymphocytes 0.0398 3 CD1D, ETS1, FYN* growth 4.71E-3 - 3.44E-2 21 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, CSF1R, FLT3LG, ICSBP1, IGHM, IL15, IL2RB, IL7R*, MAD1L1, MYBL1, MYC, NFATC2, growth of leukocytes 0.00471 19 TP53, ZAP70 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, CSF1R, FLT3LG, growth of lymphatic ICSBP1, IGHM, IL15, IL2RB, IL7R*, INPP4A*, MAD1L1, MYBL1, system cells 0.00572 21 MYC, NFATC2, NPM1*, TP53, ZAP70 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, IGHM, IL15, IL2RB, growth of lymphocytes 0.00857 16 IL7R*, MAD1L1, MYBL1, MYC, NFATC2, TP53, ZAP70 growth of B lymphocytes 0.0344 8 BCL2, BCR*, IGHM, IL2RB, MYBL1, MYC, NFATC2, TP53 cell spreading 5.97E-3 - 9.11E-3 4 cell spreading of T lymphocytes 0.00597 3 CCL5*, CD3E, CD3Z cell spreading of lymphocytes 0.00911 4 CCL5*, CD3E, CD3Z, CD47 generation 1.04E-2 - 3.98E-2 6 generation of lymphocytes 0.0104 6 CD3Z, CD5, CD86, FLT3LG, IL15, IL7R* generation of thymocytes 0.0139 2 CD3Z, CD5 generation of T lymphocytes 0.0398 3 CD3Z, CD5, CD86 cell division 1.36E-2 - 1.36E-2 3 cell division of T lymphocytes 0.0136 3 CD28, CDKN1B, STAT4 size 1.46E-2 - 1.86E-2 9 BCL2, CD86, CDKN1B, INPP5D, MAD1L1, NPM1*, RARA, SATB1, size of lymphoid organ 0.0146 9 TRA@ size of spleen 0.0186 6 BCL2, CDKN1B, INPP5D, NPM1*, RARA, SATB1 expansion 3.74E-2 - 4.78E-2 11 expansion of BCL2, CD28, CD86, CDKN1B, FLT3LG, IL15, IL7R*, MAD1L1, leukocytes 0.0374 11 MYBL1, NFATC2, ZAP70 expansion of memory T lymphocytes 0.0385 2 CD28, CDKN1B expansion of BCL2, CD28, CD86, CDKN1B, IL15, IL7R*, MAD1L1, MYBL1, lymphocytes 0.0444 10 NFATC2, ZAP70 expansion of lymphatic BCL2, CD28, CD86, CDKN1B, FLT3LG, IL15, IL7R*, MAD1L1, system cells 0.0478 11 MYBL1, NFATC2, ZAP70 contact growth inhibition 3.85E-2 - 3.85E-2 2 contact growth inhibition of T lymphocytes 0.0385 2 LCK*, ZAP70 polarization 3.85E-2 - 3.85E-2 2 polarization of leukocyte cell lines 0.0385 2 CD47, TIAM1 production 3.85E-2 - 3.98E-2 3 production of T lymphocytes 0.0385 2 FYN*, ITGA4* production of lymphocytes 0.0398 3 FYN*, IL2RB, ITGA4* adhesion 3.98E-2 - 3.98E-2 3 adhesion of B lymphocytes 0.0398 3 CD81, ITGA4*, ITGB1* Cancer 1.78E-4 - 4.78E-2 142 cell death 1.78E-4 - 4.60E-2 87 BACH2, BCL2, BCR*, CARD8, CASP2, CD79B, CD99, CTCF, DUT, cell death of lymphoma GLO1, HNRPA1*, ICSBP1, IGFBP7, IGHM, IL15, MAP4K1*, MLL*, cell lines 0.000178 25 MS4A1*, MYBL1, MYC, NCL, PRKCB1, RPLP0*, TIAM1, TP53 cell death of germ cell tumor cell lines 0.00911 4 BCL2, CCNG1, CDKN1B, TP53 cell death of B cell lymphoma cells 0.0136 3 IGHM, MS4A1*, MYC cell death of acute myeloblastic leukemia cells 0.0139 2 BCL2, RPS3A* cell death of adenocarcinoma cells 0.0139 2 BCL2, TP53 AHR, AKT1, ARHC, ASC, ATP2B1, AXIN1, BACH2, BCL2, BCL2L11, BCL6*, BCR*, BHLHB2, BIRC1*, BIRC3, CALR, CARD8, CASP2, CASP8*, CAT*, CCNG1, CD28, CD47, CD79B, CD99, CDH1, CDKN1B, CDKN1C*, CIB1, CTCF, CYCS, DAPK1, DNCL1, DUT, ETS1, GG2-1*, GLIPR1*, GLO1, GNLY*, GRIM19*, HNRPA1*, ICSBP1, IGFBP7, IGHM, IL15, IL24, ING1, ITGA6*, ITGB1*, JUND, LATS1, LCK*, LGALS9, MAD1L1, MAP3K1, MAP3K4, MAP4K1*, MLL*, MME*, MS4A1*, MYBL1, MYC, NCL, NPM1*, PCNA, PDCD6IP, PEA15, PECAM1*, PMAIP1*, PPIA*, PRF1, PRKCB1, RASA1, cell death of tumor cell RPLP0*, SKP2, SOD1, TGFBR3*, TIAM1, TMSB10, TNFRSF10C*, lines 0.0148 86 TNFRSF25*, TP53, TRA@, TRPS1, TXNRD1, UBTF, UCP2* cell death of carcinoma cells 0.0186 6 BCL2, IL24, ITGA6*, MAP3K1, MYC, TP53 AKT1, ATP2B1, BCL2, BIRC1*, CALR, CASP2, CASP8*, CDKN1B, cell death of cervical CIB1, DAPK1, GG2-1*, MAP3K4, MYC, PDCD6IP, PMAIP1*, TP53, cancer cell lines 0.0295 17 UCP2* delay in cell death of leukemia cell lines 0.0385 2 BCL2, MYC delay in cell death of tumor cell lines 0.0398 3 BCL2, CASP2, MYC cell death of colon cancer cell lines 0.046 6 BCL2, CDKN1B, ICSBP1, MYC, PECAM1*, TP53 cytostasis 8.73E-4 - 8.73E-4 4 cytostasis of bone cancer cell lines 0.000873 4 BCL6*, ETS1, PFDN5*, TP53 survival 1.64E-3 - 1.64E-3 3 survival of germ cell tumor cell lines 0.00164 3 AKT1, AKT2, APEX1 cell cycle progression 2.14E-3 - 3.98E-2 16 arrest in cell cycle progression of tumor AHR, BCL2, CCNG1, CDC25B, CDKN1B, IGHM, KLF4, MLL*, MYC, cell lines 0.00214 11 SMARCA2*, TP53 cell cycle progression of cervical cancer cell lines 0.00567 5 AHR, CDC25B, CDKN1B, CSE1L*, SMARCA2* cell cycle progression of leukemia cell lines 0.00879 5 BCL2, BCR*, CDKN1B, MYC, TP53 cell cycle progression of bone cancer cell lines 0.00911 4 AHR, BCL6*, CCNG1, MYC cell cycle progression AHR, BCL2, BCL6*, BCR*, CASP2, CCNG1, CDC25B, CDKN1B, of tumor cell lines 0.00981 16 CSE1L*, IGHM, KLF4, MLL*, MYC, PCNA, SMARCA2*, TP53 arrest in cell cycle progression of cervical cancer cell lines 0.0249 3 AHR, CDC25B, SMARCA2* arrest in cell cycle progression of leukemia cell lines 0.0249 3 BCL2, MYC, TP53 delay in cell cycle progression of tumor cell lines 0.0398 3 BCL2, CASP2, PCNA growth 2.14E-3 - 3.85E-2 14 growth of lymphoma CALR, CTCF, IGFBP7, IGHM, IL15, MLL*, MYBL1, SFRS1, SFRS2*, cell lines 0.00214 11 SFRS5*, TP53 growth of stomach cancer cell lines 0.0139 2 F2RL1, RUNX3* arrest in growth of colorectal cancer cell lines 0.0385 2 KLF4, TP53 binding 5.30E-3 - 5.30E-3 11 binding of leukemia cell ANXA2*, CD36*, CD47, ITGA4*, ITGA6*, ITGAE, ITGAL, ITGB1*, lines 0.0053 11 KLRK1, LCK*, SELPLG lymphoid cancer 5.54E-3 - 5.54E-3 15 AKT2, BCL2, BCL6*, BMI1, CUL1, CYP1B1*, LCK*, MAD1L1, lymphoid cancer 0.00554 15 MRE11A, MYC, PIK3R1*, PRF1, RARA, SKP2, TP53 development 5.97E-3 - 3.85E-2 3 development of cancer cells 0.00597 3 BCR*, LFNG, MYC development of B cell lymphoma cells 0.0385 2 LFNG, MYC progression 5.97E-3 - 1.39E-2 3 progression of tumor 0.00597 3 CDH1, MYC, TP53 progression of carcinoma 0.0139 2 MYC, TP53 G1 phase 8.79E-3 - 2.25E-2 5 G1 phase of lymphoma cell lines 0.00879 5 BCL2, IGFBP7, IGHM, MYC, TP53 arrest in G1 phase of lymphoma cell lines 0.0225 4 BCL2, IGHM, MYC, TP53 B-cell leukemia 9.11E-3 - 9.11E-3 4 B-cell leukemia 0.00911 4 BCL6*, BCR*, MYC, TP53 leukemogenesis 9.11E-3 - 9.11E-3 4 leukemogenesis 0.00911 4 AKT1, BCR*, MYC, TP53 colony formation 1.36E-2 - 3.98E-2 6 colony formation of lymphoma cell lines 0.0136 3 BACH2, CTCF, IGFBP7 colony formation of bone cancer cell lines 0.0398 3 CNOT7*, MAD1L1, TP53 retinoblastoma 1.36E-2 - 1.36E-2 3 retinoblastoma 0.0136 3 CASP8*, RASSF1, TP53 rhabdomyosarcoma 1.36E-2 - 1.36E-2 3 rhabdomyosarcoma 0.0136 3 CASP8*, RASSF1, TP53 cell viability 1.36E-2 - 3.85E-2 13 cell viability of tumor ADNP, BCL2, BCL6*, CAT*, CDKN1C*, GPX1, GRIM19*, GSTP1, cell lines 0.0136 13 IGFBP7, LCK*, SOD1, TP53, TRA1 cell viability of lung cancer cell lines 0.0139 2 BCL2, SOD1 cell viability of ovarian cancer cell lines 0.0385 2 SOD1, TP53 hyperplasia 1.39E-2 - 3.85E-2 3 hyperplasia of terminal end bud 0.0139 2 MYC, TP53 hyperplasia of lobules of mammary gland 0.0385 2 MYC, TP53 hyperplasia of retina 0.0385 2 CDKN1B, TP53 S phase 1.39E-2 - 1.39E-2 2 S phase of lymphoma cell lines 0.0139 2 BCL2, CDKN1B leukemia 1.49E-2 - 1.49E-2 15 BCL6*, BCR*, CDH1, CSF1R, DOK2, IL15, IL2RB, MLL*, MYC, leukemia 0.0149 15 MYST3, RABEP1*, RARA, RASSF1, RBM15, TP53 myeloid leukemia 2.11E-2 - 2.11E-2 9 myeloid leukemia 0.0211 9 BCR*, CDH1, CSF1R, IL2RB, MLL*, RABEP1*, RARA, RBM15, TP53 transformation 2.25E-2 - 3.85E-2 5 transformation of bone marrow cells 0.0225 4 BCR*, CCDC6, CCND2, MYC transformation of tumor 0.0385 2 MYC, TIAM1 neuroblastoma 2.49E-2 - 2.49E-2 3 neuroblastoma 0.0249 3 CASP8*, MYC, RASSF1 quantity 2.49E-2 - 3.85E-2 5 quantity of lymphoma 0.0249 3 MYC, RARA, TP53 quantity of lymphoma cell lines 0.0385 2 IGFBP7, TP53 quantity of testicular tumor 0.0385 2 TP53, XPC testicular cancer 3.22E-2 - 3.22E-2 4 testicular cancer 0.0322 4 BCL2, DNMT1, TP53, XPC invasion 3.76E-2 - 3.85E-2 8

invasion of cancer cells 0.0376 6 AKT2, CD97, CDH1, HPSE*, ITGA6*, ITGB1* invasion of leukocyte cell lines 0.0385 2 BCR*, ITGB1* invasion of malignant tumor 0.0385 2 CD97, TP53 diffuse small-cell lymphoma 3.85E-2 - 3.85E-2 2 diffuse small-cell lymphoma 0.0385 2 MYC, TP53 formation 3.85E-2 - 3.85E-2 2 formation of hepatocellular carcinoma 0.0385 2 BCL2, MYC induction 3.85E-2 - 3.85E-2 2 induction of lymphoma 0.0385 2 AKT2, BMI1 lysis 3.85E-2 - 3.85E-2 2 lysis of tumor cells 0.0385 2 CD8A, MME* ovarian carcinoma 3.85E-2 - 3.85E-2 2 ovarian carcinoma 0.0385 2 MYC, TP53 recurrence 3.85E-2 - 3.85E-2 2 recurrence of malignant tumor 0.0385 2 BCL2, TP53 teratoma 3.85E-2 - 3.85E-2 2 teratoma 0.0385 2 BCL2, DNMT1 chronic myeloid leukemia 3.98E-2 - 3.98E-2 3 chronic myeloid leukemia 0.0398 3 BCR*, CSF1R, TP53 small-cell carcinoma 3.98E-2 - 3.98E-2 3 small-cell carcinoma 0.0398 3 MME*, RASSF1, TP53 adhesion 4.05E-2 - 4.05E-2 8 adhesion of leukemia cell lines 0.0405 8 CD47, CDH1, ITGA4*, ITGA6*, ITGB1*, LAMR1*, SELPLG, ZAP70 lymphomagenesis 4.60E-2 - 4.60E-2 6 lymphomagenesis 0.046 6 BCL2, BMI1, DNMT1, MYC, PRF1, TP53 gastric cancer 4.78E-2 - 4.78E-2 11 BAT1, CANX*, CDH1, DSTN*, GCC2, HNRPH1*, MYBL1, NDUFC2, gastric cancer 0.0478 11 SEC31L1*, TP53, TTC3* Cell Death 1.78E-4 - 4.60E-2 240 cell death 1.78E-4 - 4.60E-2 217 BACH2, BCL2, BCR*, CARD8, CASP2, CD79B, CD99, CTCF, DUT, cell death of lymphoma GLO1, HNRPA1*, ICSBP1, IGFBP7, IGHM, IL15, MAP4K1*, MLL*, cell lines 0.000178 25 MS4A1*, MYBL1, MYC, NCL, PRKCB1, RPLP0*, TIAM1, TP53 AKT1, ARHC, ASC, BACH2, BCL2, BCL2L11, BCR , CABIN1 , CARD8, CASP2, CASP8*, CAT*, CBLB, CCND2, CD2, CD28, CD3E, CD47, CD79B, CD99, CDH1, CDKN1B, CTCF, CYCS, DUT, EEF1A2, GLO1, GNLY*, GPX4, HNRPA1*, ICSBP1, IGFBP7, IGHM, IL15, INPP5D, ITGA4*, ITGB1*, LCK*, LGALS9, MAP4K1*, MLL*, MS4A1*, MYBL1, MYC, NCL, NPM1*, PCNA, PIK3R1*, PMAIP1*, PRF1, cell death of leukocyte PRKCB1, PRKCH, PRKCQ, RPLP0*, SIAT1, TIAM1, TNFRSF25*, cell lines 0.000298 60 TP53, TRA@, TXNRD1 cell death of pre-T lymphocytes 0.00164 3 BCL2, BCL2L11, TP53 APRT*, ARHC, ASC, ATP2B1, AXIN1, BACH2, BCAP29, BCL2, BCL2L11, BCL6*, BCLAF1, BCR*, BHLHB2, BIN1*, BIRC1*, BIRC3, BIRC6*, BMI1, CABIN1*, CALR, CAMK4, CARD8, CASP2, CASP8*, CAT*, CBLB, CCDC6, CCL5*, CCND2, CCNG1, CD2, CD28, CD3E, CD3Z, CD47, CD79B, CD8A, CD99, CDC25B, CDH1, CDKN1B, CDKN1C*, CIB1, CITED2*, CSE1L*, CSF1R, CTCF, CUL1, CX3CR1, CXCR3, CXCR4*, CYCS, CYP1B1*, DAP3, DAPK1, DAPK2, DDB2, DDX41, DFFB, DHX9, DNCL1, DUSP6*, DUT, EBAG9, EEF1A1*, EEF1A2, EGLN1, ETS1, FEM1B, FNTA*, FRAT1, FYN*, GABPB2, GG2-1*, GLIPR1*, GLO1, GLUD1*, GNB2L1, GNLY*, GPI, GPX1, GPX4, GRIM19*, GSTP1, GZMA, HADH2, HADHA, HCCA3, HDAC1, HMGB1*, HNRPA1*, HSF2, ICAM2, ICSBP1, ID2*, IGFBP7, IGHM, IL15, IL24, IL7R*, ING1, ING1L, INPP4A*, INPP5D, IRF3, IRS2*, ITGA4*, ITGA6*, ITGAL, ITGB1*, ITGB5, JMY, JUND, KIAA0076, KLRC1, KLRD1, KSR, LAT*, LATS1, LCK*, LEF1*, LEPR*, LGALS9, LY86, MAD1L1, MADH5, MAF, MAP3K1, MAP3K2, MAP3K4, MAP4, MAP4K1*, MIF, MLL*, MME*, MOAP1, MS4A1*, MYBL1, MYC, NCL, cell death 0.00271 217 NFATC2, NPM1*, NQO2, NSEP1*, OA48-18, PCNA, PDCD2, PDCD6IP AKT1, BCL2, BCL2L11, CASP8*, CCL5*, CD2, CD28, CD3E, CD3Z, CD47, CD99, CXCR4*, FYN*, GZMA, HMGB1*, IGHM, IL15, KLRC1, cell death of T KLRD1, LAT*, LCK*, LGALS9, MAP3K2, MAP4K1*, MYC, PECAM1*, lymphocytes 0.0031 31 PRF1, SATB1, TNFRSF25*, TP53, XCL1 AKT1, BCL2, BCL2L11, CASP2, CASP8*, CCL5*, CD2, CD28, CD3E, CD3Z, CD47, CD99, CXCR4*, FYN*, GZMA, HMGB1*, IGHM, IL15, INPP5D, ITGAL, ITGB1*, KLRC1, KLRD1, LAT*, LCK*, LGALS9, cell death of MAP3K2, MAP4K1*, MS4A1*, MYC, PECAM1*, PIK3R1*, PRF1, lymphocytes 0.00316 38 PRKCB1, SATB1, TNFRSF25*, TP53, XCL1 apoptotic mitochondrial changes 0.00342 5 AKT1, DAP3, MYC, PMAIP1*, RNF7 cell death of germ cell tumor cell lines 0.00911 4 BCL2, CCNG1, CDKN1B, TP53 AKT1, ALS2CR2, API5, BCL2, BIRC1*, BIRC3, BIRC6*, CD28, EEF1A2, GG2-1*, HDAC1, MYC, PEA15, PRDX2, RARA, RNF7, anti-apoptosis 0.00953 20 SGKL*, TIAF1, TOSO*, TPT1 cell death of sympathetic neuron 0.0104 8 AKT1, BCL2, BCL2L11, CASP2, CYCS, MAP3K1, SOD1, TP53

AKT1, BCL2, BCL2L11, CASP2, CASP8*, CCL5*, CD2, CD28, CD3E, CD3Z, CD47, CD99, CXCR4*, FYN*, GZMA, HMGB1*, ICSBP1, IGHM, IL15, INPP5D, ITGAL, ITGB1*, KLRC1, KLRD1, LAT*, LCK*, LGALS9, MAP3K2, MAP4K1*, MS4A1*, MYC, NQO2, PECAM1*, cell death of leukocytes 0.0135 40 PIK3R1*, PRF1, PRKCB1, SATB1, TNFRSF25*, TP53, XCL1 cell death of B cell lymphoma cells 0.0136 3 IGHM, MS4A1*, MYC cell death of acute myeloblastic leukemia cells 0.0139 2 BCL2, RPS3A* cell death of adenocarcinoma cells 0.0139 2 BCL2, TP53 AHR, AKT1, ARHC, ASC, ATP2B1, AXIN1, BACH2, BCL2, BCL2L11, BCL6*, BCR*, BHLHB2, BIRC1*, BIRC3, CALR, CARD8, CASP2, CASP8*, CAT*, CCNG1, CD28, CD47, CD79B, CD99, CDH1, CDKN1B, CDKN1C*, CIB1, CTCF, CYCS, DAPK1, DNCL1, DUT, ETS1, GG2-1*, GLIPR1*, GLO1, GNLY*, GRIM19*, HNRPA1*, ICSBP1, IGFBP7, IGHM, IL15, IL24, ING1, ITGA6*, ITGB1*, JUND, LATS1, LCK*, LGALS9, MAD1L1, MAP3K1, MAP3K4, MAP4K1*, MLL*, MME*, MS4A1*, MYBL1, MYC, NCL, NPM1*, PCNA, PDCD6IP, PEA15, PECAM1*, PMAIP1*, PPIA*, PRF1, PRKCB1, RASA1, cell death of tumor cell RPLP0*, SKP2, SOD1, TGFBR3*, TIAM1, TMSB10, TNFRSF10C*, lines 0.0148 86 TNFRSF25*, TP53, TRA@, TRPS1, TXNRD1, UBTF, UCP2* cell death of carcinoma cells 0.0186 6 BCL2, IL24, ITGA6*, MAP3K1, MYC, TP53 AKT1, BCL2, BCL2L11, CASP2, CASP8*, CCL5*, CD2, CD28, CD3E, CD3Z, CD47, CD99, CXCR4*, EBAG9, FYN*, GZMA, HMGB1*, ICSBP1, IGHM, IL15, INPP5D, ITGAL, ITGB1*, KLRC1, KLRD1, LAT*, LCK*, LGALS9, MAP3K2, MAP4K1*, MIF, MS4A1*, MYC, NQO2, PECAM1*, PIK3R1*, PRF1, PRKCB1, RARA, SATB1, TNFRSF25*, cell death of blood cells 0.02 43 TP53, XCL1 cell death of liver cell lines 0.0216 10 AHR, AKT1, AXIN1, BCL2, CAT*, IL15, JUND, MYC, TP53, UBTF delay in cell death of neurons 0.0249 3 BCL2L11, CASP2, TP53 ADA, AKT1, BCL2, BCL2L11, CASP2, CASP8*, CCL5*, CD2, CD28, CD3E, CD3Z, CD47, CD99, CXCR4*, FYN*, GZMA, HMGB1*, ICSBP1, IGHM, IL15, INPP5D, ITGAL, ITGB1*, KLRC1, KLRD1, LAT*, LCK*, LGALS9, MAD1L1, MAP3K2, MAP4K1*, MIF, MS4A1*, MYC, cell death of lymphatic NQO2, PECAM1*, PIK3R1*, PRF1, PRKCB1, SATB1, TNFRSF25*, system cells 0.0252 43 TP53, XCL1 AKT1, ATP2B1, BCL2, BIRC1*, CALR, CASP2, CASP8*, CDKN1B, cell death of cervical CIB1, DAPK1, GG2-1*, MAP3K4, MYC, PDCD6IP, PMAIP1*, TP53, cancer cell lines 0.0295 17 UCP2* cell death of natural killer cells 0.0322 4 CD2, ITGAL, KLRC1, KLRD1 delay in cell death of leukemia cell lines 0.0385 2 BCL2, MYC release of cytochrome c from mitochondria 0.0385 2 MYC, PMAIP1* AKT1, ATP2B1, BCL2, BIRC1*, CALR, CASP2, CASP8*, CDKN1B, cell death of uterine cell CIB1, DAPK1, GG2-1*, MAP3K4, MYC, PDCD6IP, PMAIP1*, TP53, lines 0.0392 17 UCP2* cell death of cytotoxic T lymphocytes 0.0398 3 BCL2, KLRC1, KLRD1 cell death of T cell blasts 0.0398 3 CCL5*, CD3E, MYC delay in cell death of tumor cell lines 0.0398 3 BCL2, CASP2, MYC AKT1, BCL2, BIRC3, CASP8*, CDH1, CDKN1B, CYCS, CYP1B1*, DAPK1, GZMA, IL24, ITGB1*, MAP3K1, MAP4, MYC, RARA, cell death of fibroblasts 0.0438 19 TNFRSF25*, TP53, TRAF5 cell death of spermatocytes 0.0439 4 BCL6*, HSF2, SLC12A2, TP53 cell death of colon cancer cell lines 0.046 6 BCL2, CDKN1B, ICSBP1, MYC, PECAM1*, TP53 survival 1.64E-3 - 3.92E-2 27 survival of germ cell tumor cell lines 0.00164 3 AKT1, AKT2, APEX1 survival of macrophages 0.00237 4 BCL2, BCL6*, CSF1R, RASA1 survival of gonadal cell lines 0.0129 5 AKT1, AKT2, APEX1, BCL2, XRCC1 survival of esophageal cells 0.0139 2 ING1, TP53 survival of stem cells 0.0149 4 AKT1, BCL2, CDKN1B, DNMT1 BCL2, CD28, CD3E, CD86, CD8A, IL15, IL2RB, INPP5D, LEF1*, survival of lymphocytes 0.0207 13 MYC, PRKCB1, STAT4, TP53 survival of endothelial cell lines 0.0249 3 CXCR3, EDG1, MYC survival of lymphatic BCL2, BCL6*, CD28, CD3E, CD86, CD8A, CSF1R, IL15, IL2RB, system cells 0.0348 16 INPP5D, LEF1*, MYC, PRKCB1, RASA1, STAT4, TP53 survival of mesothelial cells 0.0385 2 METAP2, RASA1 BCL2, BCL6*, CD28, CD3E, CD86, CD8A, CSF1R, FLT3LG, IL15, survival of blood cells 0.0392 17 IL2RB, INPP5D, LEF1*, MYC, PRKCB1, RASA1, STAT4, TP53 death 2.98E-3 - 3.85E-2 217 APRT*, ARHC, ASC, ATP2B1, AXIN1, BACH2, BCAP29, BCL2, BCL2L11, BCL6*, BCLAF1, BCR*, BHLHB2, BIN1*, BIRC1*, BIRC3, BIRC6*, BMI1, CABIN1*, CALR, CAMK4, CARD8, CASP2, CASP8*, CAT*, CBLB, CCDC6, CCL5*, CCND2, CCNG1, CD2, CD28, CD3E, CD3Z, CD47, CD79B, CD8A, CD99, CDC25B, CDH1, CDKN1B, CDKN1C*, CIB1, CITED2*, CSE1L*, CSF1R, CTCF, CUL1, CX3CR1, CXCR3, CXCR4*, CYCS, CYP1B1*, DAP3, DAPK1, DAPK2, DDB2, DDX41, DFFB, DHX9, DNCL1, DUSP6*, DUT, EBAG9, EEF1A1*, EEF1A2, EGLN1, ETS1, FEM1B, FNTA*, FRAT1, FYN*, GABPB2, GG2-1*, GLIPR1*, GLO1, GLUD1*, GNB2L1, GNLY*, GPI, GPX1, GPX4, GRIM19*, GSTP1, GZMA, HADH2, HADHA, HCCA3, HDAC1, HMGB1*, HNRPA1*, HSF2, ICAM2, ICSBP1, ID2*, IGFBP7, IGHM, IL15, IL24, IL7R*, ING1, ING1L, INPP4A*, INPP5D, IRF3, IRS2*, ITGA4*, ITGA6*, ITGAL, ITGB1*, ITGB5, JMY, JUND, KIAA0076, KLRC1, KLRD1, KSR, LAT*, LATS1, LCK*, LEF1*, LEPR*, LGALS9, LY86, MAD1L1, MADH5, MAF, MAP3K1, MAP3K2, MAP3K4, MAP4, MAP4K1*, MIF, MLL*, MME*, MOAP1, MS4A1*, MYBL1, MYC, NCL, death of cells 0.00298 217 NFATC2, NPM1*, NQO2, NSEP1*, OA48-18, PCNA, PDCD2, PDCD6IP induction of apoptosis by intracellular signals 0.0139 7 CUL1, GPX1, MYC, PDCD6IP, PMAIP1*, RNF7, TP53 induction of apoptosis by oxidative stress 0.0385 2 GPX1, RNF7 killing 3.82E-3 - 4.39E-2 14 CD1D, ETS1, GSTP1, IL15, ITGB1*, KLRC1, KLRK1, LYAR*, NUP43, killing of cells 0.00382 14 PRF1, PTPRCAP, TP53, TRA1, TRA@ killing of lymphatic system cells 0.0399 7 CD1D, ETS1, IL15, KLRK1, PTPRCAP, TRA1, TRA@ killing of T lymphocytes 0.0439 4 IL15, PTPRCAP, TRA1, TRA@ cytotoxicity 6.28E-3 - 3.18E-2 21 CCL5*, CCR3, CD2, CD244, CD6, CD81, CMRF-35H*, FLT3LG, cytotoxicity of GZMA, HLA-DRB1, IL15, ITGAL, KLRC1, KLRD1, KLRF1, LAT*, lymphocytes 0.00628 18 NFATC2, PRF1 cytotoxicity of T CCL5*, CCR3, GZMA, HLA-DRB1, IL15, KLRC1, KLRD1, NFATC2, lymphocytes 0.00965 9 PRF1 cytotoxicity of natural CD2, CD244, CD6, CD81, CMRF-35H*, FLT3LG, IL15, ITGAL, KLRC1, killer cells 0.0181 13 KLRD1, KLRF1, LAT*, PRF1 BCL2, CCL5*, CCR3, CD2, CD244, CD6, CD81, CMRF-35H*, FLT3LG, GZMA, HLA-DRB1, IL15, ITGAL, KLRC1, KLRD1, KLRF1, cytotoxicity of cells 0.0318 21 LAT*, NFATC2, PRF1, SOD1, TP53 cytolysis 8.79E-3 - 8.79E-3 5 cytolysis of leukocyte cell lines 0.00879 5 BCL2, CD244, GNLY*, KLRB1, KLRK1 cell viability 1.36E-2 - 3.98E-2 14 cell viability of tumor ADNP, BCL2, BCL6*, CAT*, CDKN1C*, GPX1, GRIM19*, GSTP1, cell lines 0.0136 13 IGFBP7, LCK*, SOD1, TP53, TRA1 cell viability of lung cancer cell lines 0.0139 2 BCL2, SOD1 cell viability of lung cell lines 0.0139 2 BCL2, SOD1 cell viability of gonadal cell lines 0.0385 2 SOD1, TP53 cell viability of ovarian cancer cell lines 0.0385 2 SOD1, TP53 cell viability of kidney cell lines 0.0398 3 BCL6*, TRA1, VDAC1 removal 3.76E-2 - 3.76E-2 6 removal of T lymphocytes 0.0376 6 ADA, BCL2, CD2, CD86, CXCR4*, NFATC2 lysis 3.85E-2 - 3.85E-2 2 lysis of tumor cells 0.0385 2 CD8A, MME* depletion 3.98E-2 - 3.98E-2 3 depletion of T lymphocytes 0.0398 3 ADA, CXCR4*, NFATC2 Hematological System Deve 1.96E-4 - 3.74E-2 101 proliferation 1.96E-4 - 1.33E-3 68 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FYN*, GSTP1, HLA- DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, proliferation of PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, SECTM1, SIAT1, leukocytes 0.000196 66 STAT4, TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 BCL2, BCR , C1QBP , CBLB, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GSTP1, HLA-DRB1, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGB1*, KLRD1, KLRK1, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAP3K2, MIF, MLL*, MS4A1*, MYC, NCK1, PECAM1*, PHEMX, PIK3R1*, PRKCQ, PTPRCAP, RASGRP1, proliferation of blood SECTM1, SIAT1, SLC29A1, STAT4, TP53, TPT1, TRA1, TRA@, cells 0.00133 68 TRD@*, XCL1, ZAP70 activation 4.10E-3 - 7.36E-3 91 AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, activation of leukocytes 0.0041 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 90 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GP1BA, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, activation of blood cells 0.00736 91 ZAP70 growth 4.71E-3 - 4.71E-3 19 BCL2, BCR*, CD28, CD3E, CD86, CDKN1B, CSF1R, FLT3LG, ICSBP1, IGHM, IL15, IL2RB, IL7R*, MAD1L1, MYBL1, MYC, NFATC2, growth of leukocytes 0.00471 19 TP53, ZAP70 adhesion 9.11E-3 - 9.11E-3 4 adhesion of erythroid cell lines 0.00911 4 CDH1, ITGA4*, ITGA6*, ITGB1* binding 1.29E-2 - 1.29E-2 5 binding of erythroid cell lines 0.0129 5 CD47, ITGA4*, ITGAE, ITGAL, SELPLG formation 1.36E-2 - 1.36E-2 3 formation of blood platelets 0.0136 3 CASP8*, MAFG, PECAM1* agglutination 1.39E-2 - 1.39E-2 2 agglutination of blood platelets 0.0139 2 GP1BA, IGHM expansion 3.74E-2 - 3.74E-2 11 expansion of BCL2, CD28, CD86, CDKN1B, FLT3LG, IL15, IL7R*, MAD1L1, leukocytes 0.0374 11 MYBL1, NFATC2, ZAP70 Gene Expression 2.30E-4 - 4.75E-2 150 transcription 2.30E-4 - 4.39E-2 145 BCL6*, BCR*, BHLHB2, BS69, BTAF1, C19ORF2*, C21ORF107*, CALR, CAMK4, CD28, CDC25B, CDH1, CDKN1B, CGBP, CIAO1, CITED2*, CNOT7*, CREBL2, CRI1*, CSDA, CTBP1*, CTCF, CUTL1, DDX20, DEK, DNMT1, DSCR1, EDF1*, ETS1, FLJ14639, FOXP1*, GABPA, GATA3*, GRIM19*, GRLF1, GTF2I, GTF3A*, HCFC1, HDAC1, HMGN2, HNRPAB, HOP, HSF2, HTATSF1, ICSBP1, IKBKAP, ILF3*, IRF3, JMY, JUND, KLF12*, LBH, LEF1*, LRRFIP1, MADH1, MAF, MAFB, MAP3K1, MEF2C, MEF2D, MLL*, MLR1, MNT, MTA1, MXD4, MXI1, MYC, MYST3, MYST4, NCOA1*, NDNL2, NFATC2, NFIC*, NFX1, NME2, NR1D2, NSEP1*, PFDN5*, POLR2B, POLR2E*, POLR2G, POLR2H, POLR2I, POLR2K*, POLR3K, PSMC5, PTMA*, PWP1*, RARA, RASA1, RASGRP1, RBBP7, RNF4, RNPS1*, RORA, RPL6*, RPS6KA5, RREB1*, RRN3*, RUVBL1, SAP18, SATB1, SCAP, SELPLG, SIN3B, SLC2A4RG, SMARCA2*, SMARCE1*, STAT4, STATIP1, SUPT16H, TAF4, TAF9*, TARDBP*, TCEA1, TCERG1, THOC4, THRAP4, TIF1*, TMPO, TP53, TRIM28, TRIP15, TRIP3, TRIP8*, TTF1, UBE2I, UBE2V1*, UBP1, UBTF, UNRIP, YY1*, transcription 0.00023 145 ZF, ZHX1*, ZNF146*, ZNF398 AHR, ATBF1, ATF4, ATF7IP, BACH2, BCL6*, BHLHB2, BS69, C19ORF2*, C21ORF107*, CALR, CGBP, CIAO1, CITED2*, CNOT7*, CSDA, CTCF, CUTL1, DDX20, DEK, DNMT1, EDF1*, ETS1, FLJ14639, GABPA, GATA3*, GRIM19*, GTF2I, GTF3A*, HCFC1, HNRPAB, HOP, HSF2, HTATSF1, ICSBP1, IRF3, JMY, JUND, KLF12*, LBH, LEF1*, LRRFIP1, MADH1, MAF, MAFB, MEF2C, MEF2D, MLL*, MLR1, MNT, MXD4, MXI1, MYC, NCOA1*, NDNL2, NFATC2, NFIC*, NFX1, NME2, NR1D2, NSEP1*, PFDN5*, POLR2B, POLR2E*, POLR2G, POLR2I, POLR2K*, POLR3K, PSMC5, RARA, RBBP7, RNF4, RORA, RPL6*, RPS6KA5, RREB1*, RRN3*, RUVBL1, SAP18, SATB1, SCAP, SLC2A4RG, SMARCA2*, SMARCE1*, SUPT16H, TAF4, TAF9*, TARDBP*, TCEA1, TCERG1, THRAP4, transcription, DNA- TIF1*, TP53, TRIM28, TRIP15, TRIP3, TRIP8*, TTF1, UBE2V1*, dependent 0.000345 105 UBP1, UBTF, UNRIP, YY1*, ZHX1*, ZNF146* AHR, ATF4, ATF7IP, BCL6 , BS69, C19ORF2 , C21ORF107 , CIAO1, CITED2*, CNOT7*, CSDA, CTCF, CUTL1, DDX20, DEK, DNMT1, ETS1, GABPA, GATA3*, GTF2I, HCFC1, HOP, HSF2, HTATSF1, ICSBP1, IRF3, JMY, JUND, KLF12*, LBH, LEF1*, LRRFIP1, MADH1, MAF, MAFB, MLL*, MLR1, MNT, MXD4, MYC, NFIC*, NFX1, NSEP1*, POLR2B, POLR2E*, POLR2G, POLR2I, POLR2K*, PSMC5, RBBP7, RNF4, RUVBL1, SAP18, SMARCA2*, SMARCE1*, SUPT16H, TAF4, transcription from Pol II TAF9*, TARDBP*, TCERG1, THRAP4, TIF1*, TP53, TRIM28, TRIP15, promoter 0.0113 68 UBP1, UNRIP, YY1* transcription of RNA 0.024 6 CD28, HMGN2, NFIC*, POLR2B, POLR2K*, TP53 transcription from Pol I promoter 0.0439 4 POLR2K*, RRN3*, TTF1, UBTF bending 2.47E-2 - 2.47E-2 5 bending of DNA 0.0247 5 GTF3A*, HMGB1*, LEF1*, UBTF, YY1* recruitment 2.49E-2 - 2.49E-2 3 recruitment of mRNA 0.0249 3 EIF3S10*, EIF4A1*, EIF4B* expression 4.75E-2 - 4.75E-2 7 expression of RNA 0.0475 7 CD28, DHX9, HMGN2, NFIC*, POLR2B, POLR2K*, TP53 Cell-To-Cell Signaling and In3.87E-4 - 4.41E-2 104 activation 3.87E-4 - 3.85E-2 91 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, activation of SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, TRA@, lymphocytes 0.000387 86 TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GZMA, HLA-DMA, HLA-DQA1, HLA- DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, activation of PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, mononuclear SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, leukocytes 0.000435 87 TRA@, TRD@*, XCL1, ZAP70 BCL2, BCL6*, C1QBP*, CASP8*, CBLB, CCL5*, CD1D, CD2, CD28, CD36*, CD3E, CD3Z, CD47, CD7*, CD74, CD81, CD86, CD8A, CDKN1B, CDW52*, CXCR4*, DOK2, FYN*, GATA3*, HLA-DMA, HLA- DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IL15, IL2RB, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, MAD1L1, MAF, MAP3K2, MIF, MYC, NCK1, NFATC2, activation of T PECAM1*, PHEMX, PRF1, PRKCQ, PTPRCAP, RASGRP1, SECTM1, lymphocytes 0.000465 66 SH2D1A*, STAT4, TP53, TRA1, TRA@, TRD@*, XCL1, ZAP70 activation of thymocytes 0.00189 5 CD2, CD3E, CD3Z, FYN*, LAT* AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, activation of lymphatic RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, system cells 0.00289 90 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6*, BCR*, C1QBP*, CASP8*, CBLB, CCL5*, CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, activation of leukocytes 0.0041 90 TPT1, TRA1, TRA@, TRD@*, XCL1, ZAP70 AIP, BCL2, BCL6 , BCR , C1QBP , CASP8 , CBLB, CCL5 , CCND2, CD1D, CD2, CD244, CD28, CD36*, CD3E, CD3Z, CD47, CD5, CD7*, CD74, CD79B, CD81, CD86, CD8A, CDKN1B, CDW52*, CSF1R, CXCR4*, DOK2, FLT3LG, FYN*, GATA3*, GP1BA, GPR44, GZMA, HLA-DMA, HLA-DQA1, HLA-DRA*, HLA-DRB1, ICSBP1, ID2*, IGHM, IGKC, IL15, IL16, IL2RB, IL7R*, IMPDH2, INPP5D, IRS2*, ITGAL, ITGB1*, KLRC1, KLRD1, KLRK1, KSR, LAT*, LCK*, LEF1*, LILRB1, LNK, LPIN1, LY86, MAD1L1, MAF, MAP3K2, MIF, MS4A1*, MYC, NCK1, NFATC2, PECAM1*, PHEMX, PIK3R1*, PRF1, PRKCQ, PTPRCAP, RASGRP1, RBPSUH*, SECTM1, SH2D1A*, SIAT1, STAT4, TNFRSF25*, TP53, TPT1, TRA1, TRA@, TRD@*, XCL1, activation of blood cells 0.00736 91 ZAP70 activation of hybridomas 0.0139 2 TRA1, TRA@ AIP, BCR*, CCND2, CD244, CD3E, CD3Z, CD74, CD79B, CD86, CD8A, FYN*, IGHM, IGKC, IL15, IL2RB, IL7R*, INPP5D, LEF1*, LNK, activation of B LPIN1, LY86, MS4A1*, MYC, PECAM1*, PIK3R1*, PTPRCAP, lymphocytes 0.0175 29 RBPSUH*, SIAT1, TPT1 activation of natural killer cells 0.0345 9 CCL5*, CD2, CD244, CD81, FLT3LG, IL15, ITGAL, KLRC1, KLRD1 activation of helper T lymphocytes 0.0385 2 CD28, CD3Z binding 1.27E-3 - 4.41E-2 22 binding of T CALR, CCL5*, CCR3, CD2, CD47, CXCR3, HLA-DMA, ITGA4*, lymphocytes 0.00127 12 ITGAL, ITGB1*, KLRK1, SELPLG binding of leukemia cell ANXA2*, CD36*, CD47, ITGA4*, ITGA6*, ITGAE, ITGAL, ITGB1*, lines 0.0053 11 KLRK1, LCK*, SELPLG binding of leukocyte ANXA2*, BCR*, CD2, CD36*, CD47, CXCR3, IGKC, ITGA4*, ITGA6*, cell lines 0.00981 16 ITGAE, ITGAL, ITGB1*, KLRK1, LCK*, SELPLG, SIAT1 binding of erythroid cell lines 0.0129 5 CD47, ITGA4*, ITGAE, ITGAL, SELPLG CALR, CCL5*, CCR3, CD2, CD47, CD86, CXCR3, HLA-DMA, ITGA4*, binding of lymphocytes 0.0136 13 ITGAL, ITGB1*, KLRK1, SELPLG binding of eosinophils 0.0322 4 CCL5*, CCR3, ITGA4*, ITGB1*

binding of keratinocytes 0.0385 2 ITGA6*, ITGAL binding of helper inducer T lymphocytes 0.0398 3 CCL5*, CCR3, SELPLG binding of mononuclear CALR, CCL5*, CCR3, CD2, CD3E, CD47, CD86, CXCR3, HLA-DMA, leukocytes 0.0441 14 ITGA4*, ITGAL, ITGB1*, KLRK1, SELPLG response 2.49E-2 - 2.49E-2 3 response of synapse 0.0249 3 FYN*, VDAC1, VDAC3 long-term potentiation 3.22E-2 - 3.22E-2 4 long-term potentiation of synapse 0.0322 4 FYN*, PRKACB*, VDAC1, VDAC3 contact growth inhibition 3.85E-2 - 3.85E-2 2 contact growth inhibition of T lymphocytes 0.0385 2 LCK*, ZAP70 rearrangement 3.85E-2 - 3.85E-2 2 rearrangement of focal adhesions 0.0385 2 CDKN1B, ITGB1* quantity 4.17E-2 - 4.17E-2 5 quantity of focal adhesions 0.0417 5 CAPNS1, GNB2L1, ITGB1*, MYC, TP53 DNA Replication, Recombina7.77E-4 - 4.39E-2 77 metabolism 7.77E-4 - 4.60E-3 76 AKT1, APEX1, ATF7IP, BAF53A, BANF1, BCL2, BCR , BIN1 , CASP2, CD2, CD28, CD3E, CD47, CDH1, CDK2AP1, CDKN1B, CIB1, CTCF, DAPK1, DDB1, DDB2, DFFB, DNMT1, DUT, ECGF1, FYN*, GATA3*, GPX1, GPX4, GTF3A*, GZMA, HDAC1, HMGB1*, HNRPA1*, IL7R*, ING1, LEF1*, MCM3AP, MCM5, MCM7, MRE11A, MYC, MYST3, MYST4, NAP1L1*, NAP1L4, NCL, PCNA, PEA15, PIK3R1*, POLE3, RAN*, RARA, RBBP4*, RBBP7, REPIN1, REV1L, REV3L, RPA1*, RPS6KA5, SATB1, SET*, SMARCE1*, SOD1, SPHAR, SUPT16H, TIA1, TIAM1, TP53, TSN, TTF1, UBE2N, UBTF, XPC, metabolism of DNA 0.000777 76 XRCC1, YY1* BAF53A, CD28, CD3E, GATA3*, GPX4, HDAC1, MYC, MYST3, MYST4, NAP1L1*, NAP1L4, RARA, RBBP4*, RBBP7, RPS6KA5, DNA packaging 0.0046 20 SATB1, SET*, SMARCE1*, SUPT16H, TTF1 remodeling 8.78E-3 - 8.78E-3 10 remodeling of BAF53A, CD28, CD3E, GATA3*, HDAC1, MYC, RARA, RBBP4*, chromatin 0.00878 10 RBBP7, TTF1 replication 1.39E-2 - 1.39E-2 24 BCL2, CDH1, CDK2AP1, CDKN1B, DUT, ECGF1, FYN*, LEF1*, MCM3AP, MCM5, MCM7, MRE11A, MYC, NAP1L1*, NCL, PCNA, replication of DNA 0.0139 24 PEA15, POLE3, REPIN1, REV3L, RPA1*, SET*, SPHAR, TP53 modification 1.58E-2 - 1.58E-2 13 modification of BAF53A, CD28, CD3E, GATA3*, HDAC1, MYC, MYST4, RARA, chromatin 0.0158 13 RBBP4*, RBBP7, RPS6KA5, SATB1, TTF1 bending 2.47E-2 - 2.47E-2 5 bending of DNA 0.0247 5 GTF3A*, HMGB1*, LEF1*, UBTF, YY1* cleavage 3.32E-2 - 3.32E-2 7 cleavage of DNA 0.0332 7 APEX1, DFFB, HMGB1*, MRE11A, MYC, NME2, TP53 opening 3.85E-2 - 3.85E-2 2 opening of DNA 0.0385 2 RPA1*, XPC unwinding 4.39E-2 - 4.39E-2 4 unwinding of DNA 0.0439 4 LEF1*, MCM7, MRE11A, NCL Cellular Function and Mainte8.73E-4 - 3.85E-2 20 cytostasis 8.73E-4 - 1.82E-2 8 cytostasis of bone cancer cell lines 0.000873 4 BCL6*, ETS1, PFDN5*, TP53 cytostasis of bone cell lines 0.00911 4 BCL6*, ETS1, PFDN5*, TP53

cytostasis of fibroblasts 0.0182 5 ADA, ADK*, HDAC1, TAF9*, TP53 respiration 3.51E-3 - 9.11E-3 8 respiration of cells 0.00351 8 GLB1, MTO1*, SDHB, SURF1, UCP2*, UQCRC2, UQCRH, VDAC1 aerobic respiration 0.00911 4 SDHB, SURF1, UQCRC2, UQCRH contact growth inhibition 3.85E-2 - 3.85E-2 2 contact growth inhibition of T lymphocytes 0.0385 2 LCK*, ZAP70 receptor-mediated endocytosis 3.85E-2 - 3.85E-2 2

receptor-mediated endocytosis of vesicles 0.0385 2 CABIN1*, REPS1 Skeletal and Muscular Disor 8.73E-4 - 3.98E-2 11 cytostasis 8.73E-4 - 8.73E-4 4 cytostasis of bone cancer cell lines 0.000873 4 BCL6*, ETS1, PFDN5*, TP53 cell cycle progression 9.11E-3 - 9.11E-3 4 cell cycle progression of bone cancer cell lines 0.00911 4 AHR, BCL6*, CCNG1, MYC atrophy 1.39E-2 - 1.39E-2 2 atrophy of skeletal muscle 0.0139 2 AKT1, AKT2 colony formation 3.98E-2 - 3.98E-2 3 colony formation of bone cancer cell lines 0.0398 3 CNOT7*, MAD1L1, TP53

Global Functional Analysis of the Upregulated Genes High Level Function Significance # Genes Genes Immune Response 6.14E-16 - 3.94E-3 121 immune response 6.14E-16 - 1.13E-3 115 ADORA2A, AIM2, ALOX5*, ALOX5AP, BCL2A1, BST1, BST2, C1ORF29, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CD24*, CD44*, CEACAM1*, CLECSF2, CLECSF9*, CR1*, CXCL16, CXCL2*, EDN1, ETS2*, FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FES, FGR, FPR1, FPRL1*, FYB*, GCA, GPR105, GULP1, HGF, HHEX, ICAM1, IER3, IFITM3, IFNAR1, IFNGR2, IGF1R, IGHG1*, IGSF6, IL10RB, IL18R1, IL18RAP, IL1A, IL1B*, IL1R1, IL1R2*, 6.14E-16 115 IL1RAP, IL1RN*, IL4R, IL8*, IL8RA, IL9R, INDO, IRAK2, ITGAM*, JAK3*, LY96, LYN, MAIL, MAPK14*, MMP9, MR1*, MX1, NCF1*, NFIL3, NFKB2*, ORM1*, ORM2, OSM*, PDCD1LG1*, PGLYRP, PIK3AP1, PIK3CG, PLAU*, PLAUR*, PLSCR1*, PML*, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, PTX3, REN, RIPK2, SELL, SERPINB1*, SOCS3*, SOD2*, SPP1, STAT5A, STAT5B*, TAL1, TAPBP, TCF3*, TLR4*, TLR6, TNF, TNFAIP3*, immune response TNFAIP6*, TNFRSF6, TNFSF13B*, TRIM22, TXN*

ADORA2A, ALOX5*, ALOX5AP, CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, CXCL2*, EDN1, FCAR*, FCER1G, FCGR1A*, 1.72E-10 47 FCGR2B*, FPR1, FPRL1*, ICAM1, IGHG1*, IL10RB, IL18RAP, IL1A, IL1B*, IL1RN*, IL8*, IL8RA, IRAK2, ITGAM*, LY96, LYN, MAIL, innate immune MMP9, MX1, NCF1*, ORM1*, PIK3CG, PLAU*, PLAUR*, PTGER3, response PTX3, RIPK2, SELL, SPP1, TLR4*, TNF, TNFAIP6*, TXN* ALOX5AP, CCL3, CCL4, CCR1*, CD44*, FCGR2B*, FES, FYB*, immune response of 7.61E-08 19 IER3, IGHG1*, IL1R1, IL1RN*, LYN, PIK3AP1, SPP1, TAPBP, TLR4*, mice TNF, TNFAIP3* ALOX5AP, CCL3, CCL4, CCR1*, CD44*, FCGR2B*, FES, FYB*, immune response of 0.00000012 20 IER3, IGHG1*, IL1R1, IL1RN*, LYN, OSM*, PIK3AP1, SPP1, TAPBP, organism TLR4*, TNF, TNFAIP3* CXCL2*, FCAR*, FCGR1A*, FCGR2A*, FCGR2B*, FGR, ITGAM*, immune response of 0.00000898 16 LYN, PGLYRP, PIK3CG, PTEN, PTPNS1*, PTPRC, TAPBP, TNF, blood cells TNFRSF6 immune response of CXCL2*, FCAR*, FCGR2A*, FCGR2B*, FGR, ITGAM*, LYN, phagocytes 0.0000178 11 PGLYRP, PIK3CG, TNF, TNFRSF6 immune response of CXCL2*, FCAR*, FCGR2A*, FGR, ITGAM*, LYN, PIK3CG, TNF, granulocytes 0.0000862 9 TNFRSF6 immune response of connective tissue cells 0.000101 8 FCGR2A*, FCGR2B*, FGR, LYN, PGLYRP, TLR4*, TNF, TNFRSF6 immune response of neutrophils 0.000131 8 CXCL2*, FCAR*, FCGR2A*, FGR, ITGAM*, LYN, PIK3CG, TNF immune response of macrophages 0.00014 7 FCGR2A*, FCGR2B*, FGR, LYN, PGLYRP, TNF, TNFRSF6 immune response of CXCL2*, FCAR*, FCGR2A*, FCGR2B*, FGR, ITGAM*, LYN, lymphatic system cells 0.000333 13 PGLYRP, PIK3CG, PTPRC, TAPBP, TNF, TNFRSF6 immune response of CXCL2*, FCAR*, FCGR2A*, FGR, ITGAM*, LYN, PIK3CG, PTPRC, leukocytes 0.00113 11 TAPBP, TNF, TNFRSF6 cell movement 6.19E-10 - 1.32E-3 45 ALOX5AP, ANXA1, CAMP, CASP1*, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCER1G, FPR1, GSN, ICAM1, IL1B*, IL4R, cell movement of bone 6.19E-10 30 IL8*, IL8RA, ITGAM*, JAK2*, MAPK14*, MAPKAPK2, MMP9, OSM*, marrow cells PIK3CG, PLAU*, PTPNS1*, SELL, TNF, TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCER1G, FPR1, GSN, ICAM1, IL1B*, IL4R, cell movement of 2.51E-09 28 IL8*, IL8RA, ITGAM*, MAPK14*, MAPKAPK2, OSM*, PIK3CG, granulocytes PLAU*, PTPNS1*, SELL, TNF, TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCER1G, FCGR2B*, FPR1, FPRL1*, FYB*, GSN, HGF, ICAM1, IL1B*, IL4R, IL8*, IL8RA, 3.33E-09 42 ITGAM*, LYN, MAPK14*, MAPKAPK2, MMP9, OSM*, PIK3CG, cell movement of PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, STAT3, TLR4*, TNF, leukocytes TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCAR*, FCER1G, FPR1, FPRL1*, FYB*, GSN, HGF, ICAM1, IL1A, IL1B*, IL4R, IL8*, IL8RA, 1.06E-08 41 ITGAM*, JAK2*, MAPK14*, MAPKAPK2, MMP9, OSM*, PIK3CG, cell movement of PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, TNF, TNFRSF6, lymphatic system cells TXN* CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL2*, FCAR*, FPR1, FPRL1*, GSN, HGF, ICAM1, IL1A, IL1B*, IL8RA, cell movement of 1.19E-08 26 MAPK14*, PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, antigen presenting cells TNF ALOX5AP, ANXA1, CAMP, CASP1*, CCL3, CCL4, CXCL2*, FCER1G, FPR1, GSN, ICAM1, IL1B*, IL8*, IL8RA, ITGAM*, cell movement of 1.24E-08 23 MAPK14*, MAPKAPK2, PIK3CG, PLAU*, SELL, TNF, TNFRSF6, neutrophils TXN* CAMP, CCL20, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCAR*, cell movement of 0.000000072 22 FPR1, FPRL1*, GSN, HGF, ICAM1, IL8RA, MAPK14*, PIK3CG, macrophages PLAU*, PLAUR*, PTPNS1*, REN, SELL, TNF cell movement of CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, FPR1, ICAM1, dendritic cells 0.000000456 14 IL1A, IL1B*, IL8RA, REN, SPP1, TNF cell movement of T 0.00000307 18 CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, lymphocytes FYB*, HGF, ICAM1, IL8*, PLAU*, REN, SELL, SPP1, TNF, TNFRSF6 CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FPR1, FPRL1*, FYB*, HGF, ICAM1, IL8*, IL8RA, MAPK14*, cell movement of 0.00000345 27 MMP9, PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, mononuclear leukocytes TNF, TNFRSF6 cell movement of CAMP, CCL20, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FPR1, monocytes 0.0000165 16 FPRL1*, HGF, IL8RA, MAPK14*, PLAUR*, PTPNS1*, REN, TNF cell movement of CCL3, CCL4, CCR1*, FPR1, IL1B*, IL4R, IL8*, MAPK14*, OSM*, eosinophils 0.0000211 12 PTPNS1*, TNF, TXN* cell movement of peripheral blood 0.0000755 6 leukocytes CCL3, CCL4, FPR1, FPRL1*, PLAUR*, SELL CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, cell movement of 0.0000937 20 FYB*, HGF, ICAM1, IL8*, MMP9, PIK3CG, PLAU*, REN, SELL, lymphocytes SPP1, TNF, TNFRSF6 cell movement of naive lymphocytes 0.00132 4 CCL20, CCL4, SELL, TNF infiltration 8.29E-9 - 8.28E-4 22 infiltration of 8.29E-09 16 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CXCL2*, FCER1G, granulocytes ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CXCL2*, FCER1G, ICAM1, IL8*, infiltration of neutrophils 0.000000111 13 MAPK14*, PIK3CG, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, FCAR*, infiltration of lymphatic 0.00000029 20 FCER1G, ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, PLAU*, system cells REN, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, 0.000000405 20 FCER1G, FCGR2B*, ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, infiltration of leukocytes REN, SELL, STAT3, TNF, TNFRSF6 infiltration of macrophages 0.000326 7 CCL3, CCL4, FCAR*, ICAM1, PLAU*, REN, SELL infiltration of eosinophils 0.000828 5 CCL3, CCR1*, IL4R, MAPK14*, OSM* migration 9.86E-9 - 2.68E-3 34 ANXA1, CCL3, CCL4, CEACAM1*, FPR1, ICAM1, IL1B*, IL8*, migration of bone 9.86E-09 18 ITGAM*, JAK2*, MAPKAPK2, MMP9, PLAU*, PTPNS1*, SELL, TNF, marrow cells TNFRSF6, TXN* ANXA1, CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCER1G, FPR1, FPRL1*, FYB*, HGF, ICAM1, 8.07E-08 33 IL1B*, IL8*, IL8RA, ITGAM*, LYN, MAPK14*, MAPKAPK2, MMP9, PIK3CG, PLAU*, PLAUR*, PTPNS1*, SELL, SPP1, TNF, TNFRSF6, migration of leukocytes TXN* ANXA1, CCL3, CCL4, CEACAM1*, FPR1, ICAM1, IL1B*, IL8*, migration of 9.76E-08 16 ITGAM*, MAPKAPK2, PLAU*, PTPNS1*, SELL, TNF, TNFRSF6, granulocytes TXN* ANXA1, CCL20, CCL3, CCL4, CD44*, CEACAM1*, FPR1, FYB*, migration of lymphatic 0.000000724 24 HGF, ICAM1, IL1B*, IL8*, ITGAM*, JAK2*, MAPK14*, MAPKAPK2, system cells MMP9, PLAU*, PTPNS1*, SELL, SPP1, TNF, TNFRSF6, TXN* ANXA1, FPR1, ICAM1, IL1B*, IL8*, ITGAM*, MAPKAPK2, PLAU*, migration of neutrophils 0.00000122 12 SELL, TNF, TNFRSF6, TXN* migration of T CCL20, CCL3, CCL4, CD44*, CEACAM1*, FYB*, HGF, ICAM1, lymphocytes 0.0000624 11 PLAU*, SPP1, TNF migration of dendritic cells 0.000136 9 CCL20, CCL3, CCL4, CD44*, CEACAM1*, ICAM1, IL1B*, SPP1, TNF migration of 0.000218 14 CCL20, CCL3, CCL4, CD44*, CEACAM1*, FYB*, HGF, ICAM1, IL8*, mononuclear leukocytes MAPK14*, PLAU*, PTPNS1*, SPP1, TNF migration of CCL20, CCL3, CCL4, CD44*, CEACAM1*, FYB*, HGF, ICAM1, IL8*, lymphocytes 0.00026 12 PLAU*, SPP1, TNF migration of antigen CCL20, CCL3, CCL4, CD44*, CEACAM1*, HGF, ICAM1, IL1B*, presenting cells 0.000392 12 MAPK14*, PTPNS1*, SPP1, TNF migration of Langerhans cells 0.000479 4 CCL20, CD44*, ICAM1, SPP1 migration of eosinophils 0.00268 5 CCL4, IL1B*, PTPNS1*, TNF, TXN* inflammation 7.20E-8 - 2.53E-4 26 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, FCAR*, FCGR2B*, FGR, ICAM1, IFNGR2, IL18R1, IL1B*, IL1RN*, ITGAM*, 0.000000072 26 LYN, MMP9, OSM*, PIK3CG, PRKR, SOD2*, SPP1, TNF, TNFAIP3*, inflammation TNFRSF6 ALOX5AP, CCL3, CCL4, CCR1*, CD44*, FCGR2B*, SPP1, TNF, inflammation of mice 0.0000128 9 TNFAIP3* inflammation of granulocytes 0.0000219 8 CXCL2*, FCAR*, FGR, ITGAM*, LYN, PIK3CG, TNF, TNFRSF6 CXCL2*, FCAR*, FGR, IL18R1, ITGAM*, LYN, PIK3CG, TNF, inflammation of cells 0.000253 9 TNFRSF6 fever 3.30E-7 - 3.30E-7 7 fever 0.00000033 7 CCL3, CCL4, IL1A, IL1B*, IL1RN*, PTGER3, TNF phagocytosis 1.78E-6 - 3.94E-3 17 FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FGR, GULP1, 0.00000178 15 ITGAM*, LYN, PGLYRP, PRKCD, PTEN, PTPNS1*, TLR4*, phagocytosis of cells TNFRSF6 ADORA2A, FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FGR, 0.00000525 17 GULP1, IGHG1*, ITGAM*, LYN, PGLYRP, PRKCD, PTEN, PTPNS1*, phagocytosis TLR4*, TNFRSF6 phagocytosis of red blood cells 0.00000534 7 FCGR1A*, FCGR2A*, FGR, ITGAM*, LYN, PTEN, PTPNS1* phagocytosis, engulfment 0.000016 6 FCER1G, FCGR1A*, FCGR2B*, GULP1, IGHG1*, PTPNS1* phagocytosis of blood FCGR1A*, FCGR2A*, FCGR2B*, FGR, ITGAM*, LYN, PGLYRP, cells 0.0000165 10 PTEN, PTPNS1*, TNFRSF6 phagocytosis of connective tissue cells 0.00156 5 FCGR2A*, FCGR2B*, PGLYRP, TLR4*, TNFRSF6 phagocytosis of macrophages 0.00198 4 FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 phagocytosis of leukocyte cell lines 0.00394 4 FCGR2A*, FCGR2B*, FGR, PRKCD chemokinesis 2.48E-6 - 2.48E-6 5 chemokinesis of neutrophils 0.00000248 5 CCL3, CCL4, CXCL2*, IL8*, TNF degranulation 3.99E-6 - 1.84E-3 7 degranulation of neutrophils 0.00000399 6 CCL3, CCL4, CXCL2*, IL8*, PLAUR*, TNF degranulation of leukocytes 0.00184 7 CCL3, CCL4, CXCL2*, IL8*, LYN, PLAUR*, TNF activation 1.14E-5 - 3.52E-3 56 BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR*, FCGR2B*, FYB*, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, PDCD1LG1*, 0.0000114 56 PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, activation of leukocytes TNFSF13B*, TXN* CCL3, CCL4, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL8*, IL9R, INDO, JAK3*, MAPK14*, MMP9, PDCD1LG1*, PIK3CG, PRKR, 0.0000199 40 PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, activation of T SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TLR4*, TNF, lymphocytes TNFRSF6, TXN* CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR , FCGR2B*, FYB*, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, 0.0000331 54 MAPK14*, MMP9, NFKB2*, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, activation of lymphatic PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, system cells TAL1, TCF3*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CCL3, CCL4, CD44 , CEACAM1 , CR1 , ETS2 , FCGR2B , FYB , ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, 0.0000472 49 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SERPINB1*, SPP1, activation of STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, lymphocytes TNFSF13B*, TXN* activation of neutrophils 0.00075 8 FCAR*, IL1A, IL1B*, IL1RN*, IL8*, ITGAM*, SELL, TNF activation of CCL3, CCL4, EDN1, ICAM1, IL1B*, IL8*, LY96, PTGER3, TLR4*, macrophages 0.00221 10 TNF CD44*, FCGR2B*, IFNAR1, IL4R, LY96, LYN, PIK3AP1, PRKCD, activation of B 0.00309 18 PTEN, PTPN2, PTPNS1*, PTPRC, STAT5A, TCF3*, TLR4*, TNF, lymphocytes TNFSF13B*, TXN* activation of antigen CCL3, CCL4, EDN1, ICAM1, IFNAR1, IL1B*, IL8*, LY96, PTGER3, presenting cells 0.00352 12 TLR4*, TNF, TNFRSF6 chemotaxis 2.96E-5 - 1.61E-3 23 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, CXCL2*, FCER1G, chemotaxis of 0.0000296 22 FPR1, FPRL1*, IL1B*, IL8*, IL8RA, ITGAM*, LYN, MMP9, PIK3CG, leukocytes PLAU*, PLAUR*, SPP1, TNF, TXN* chemotaxis of peripheral blood 0.0000869 5 monocytes CCL3, CCL4, FPR1, FPRL1*, PLAUR* chemotaxis of CAMP, CCL3, CCL4, CXCL2*, FCER1G, FPR1, IL1B*, IL8*, IL8RA, neutrophils 0.000168 12 ITGAM*, PIK3CG, TNF CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, CXCL2*, FCER1G, chemotaxis of lymphatic 0.000279 20 FPR1, FPRL1*, IL1A, IL1B*, IL8*, IL8RA, ITGAM*, MMP9, PIK3CG, system cells PLAUR*, SPP1, TNF chemotaxis of dendritic cells 0.000326 7 CCL20, CCL3, CCL4, FPR1, IL1A, IL1B*, TNF chemotaxis of T lymphocytes 0.000738 9 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, IL8*, SPP1, TNF chemotaxis of 0.00123 14 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, FPR1, FPRL1*, IL8*, mononuclear leukocytes MMP9, PIK3CG, PLAUR*, SPP1, TNF chemotaxis of CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, IL8*, MMP9, PIK3CG, lymphocytes 0.00143 11 SPP1, TNF chemotaxis of antigen CAMP, CCL20, CCL3, CCL4, FPR1, FPRL1*, IL1A, IL1B*, PIK3CG, presenting cells 0.00161 11 PLAUR*, TNF proliferation 3.89E-5 - 3.88E-4 40 CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000389 40 MMP9, NFE2, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, proliferation of PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT3, lymphatic system cells STAT5A, STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, MMP9, 0.0000443 37 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTPN2, proliferation of PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, STAT5B*, lymphocytes TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000521 38 MMP9, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, proliferation of PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, leukocytes STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CD44*, CEACAM1*, CR1*, ETS2*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL9R, INDO, JAK3*, MMP9, PDCD1LG1*, PIK3CG, proliferation of T 0.0000923 29 PRKR, PTEN, PTPN2, PTPNS1*, PTPRJ, RIPK2, SPP1, STAT5A, lymphocytes STAT5B*, TLR4*, TNF, TNFRSF6, TXN* proliferation of B CD44*, FCGR2B*, IFNAR1, IL4R, LY96, LYN, PIK3AP1, PRKCD, lymphocytes 0.000388 16 PTEN, PTPN2, PTPRC, STAT5A, TLR4*, TNF, TNFSF13B*, TXN* recruitment 7.60E-5 - 2.86E-3 13 recruitment of CCL3, CCL4, CCR1*, CXCL2*, ICAM1, IGHG1*, IL8*, PIK3CG, SELL, leukocytes 0.000076 12 TLR4*, TNF, TXN* recruitment of neutrophils 0.000101 8 CCL3, CCL4, CCR1*, CXCL2*, IL8*, PIK3CG, TLR4*, TNF recruitment of granulocytes 0.000306 9 CCL3, CCL4, CCR1*, CXCL2*, IGHG1*, IL8*, PIK3CG, TLR4*, TNF recruitment of lymphatic CCL3, CCL4, CCR1*, CD44*, CXCL2*, ICAM1, IGHG1*, IL8*, system cells 0.000391 11 PIK3CG, TLR4*, TNF recruitment of lymphocytes 0.00258 6 CCL3, CCR1*, CXCL2*, ICAM1, IL8*, TNF recruitment of natural killer T lymphocytes 0.00286 2 CXCL2*, TNF hypersensitive reaction 8.69E-5 - 1.53E-4 11 hypersensitive reaction of mice 0.0000869 5 CCL3, CCL4, CCR1*, CD44*, SPP1 CASP1*, CCL3, CCL4, CCR1*, CD44*, FCGR2B*, IFNGR2, LYN, hypersensitive reaction 0.000153 11 PRKR, SPP1, TNF priming 1.12E-4 - 1.12E-4 4 priming of neutrophils 0.000112 4 IL1A, IL1B*, IL8*, TNF response 1.51E-4 - 2.49E-3 13 response of lymphatic CCL3, CCL4, CXCL2*, FCGR2A*, FCGR2B*, ICAM1, IL8*, ITGAM*, system cells 0.000151 13 PGLYRP, STAT5A, STAT5B*, TNF, TNFRSF6 response of antigen presenting cells 0.00017 6 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TNF, TNFRSF6 response of neutrophils 0.00025 7 CCL3, CCL4, CXCL2*, FCGR2A*, IL8*, ITGAM*, TNF response of macrophages 0.000828 5 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 CCL3, CCL4, CXCL2*, FCGR2A*, ICAM1, IL8*, ITGAM*, STAT5A, response of leukocytes 0.00249 10 STAT5B*, TNF transmigration 5.35E-4 - 3.94E-3 7 transmigration of leukocytes 0.000535 7 CCL3, CCL4, FPR1, IL1B*, IL8*, PTPNS1*, TNF transmigration of lymphatic system cells 0.0021 6 CCL3, CCL4, FPR1, IL8*, PTPNS1*, TNF transmigration of granulocytes 0.00394 4 FPR1, IL8*, PTPNS1*, TNF influx 5.77E-4 - 5.77E-4 5 influx of leukocytes 0.000577 5 CCL3, CCL4, CXCL2*, MMP9, TNF engulfment 8.38E-4 - 2.86E-3 7 engulfment of lymphatic system cells 0.000838 7 FCGR2A*, FCGR2B*, IL1A, ITGAM*, PGLYRP, TNF, TNFRSF6 engulfment of eosinophils 0.00286 2 IL1A, TNF acute phase reaction 2.70E-3 - 2.70E-3 3 acute phase reaction 0.0027 3 IL1B*, OSM*, TNF emigration 2.85E-3 - 2.85E-3 4

emigration of leukocytes 0.00285 4 ANXA1, CD44*, SELL, SPP1 aggregation 2.86E-3 - 2.86E-3 2 aggregation of monocyte-derived 0.00286 2 dendritic cells CD44*, TNF Inflammatory Disease 1.15E-10 - 2.86E-3 41 inflammatory disease 1.15E-10 - 1.15E-10 41 ALOX5*, ALOX5AP, ARG1, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, CYBB*, DAF*, FCGR2B*, ICAM1, IFNGR1, IFNGR2, IGHG1*, IL10RB, IL17R, IL1A, IL1B*, IL1R1, IL1R2*, IL1RN*, IL4R, 1.15E-10 41 IL8*, LYN, MAPKAPK2, NCF1*, NFKB2*, NFKBIA*, OSM*, PLAU*, PRKR, PTPNS1*, PTPRC, SOCS3*, SPP1, STAT3, TNF, TNFRSF6, inflammatory disease TNFSF13B* arthritis 1.63E-8 - 1.63E-8 18 ALOX5AP, CCL3, CD44*, CXCL2*, FCGR2B*, ICAM1, IGHG1*, 1.63E-08 18 IL17R, IL1A, IL1B*, IL1R1, IL1R2*, IL1RN*, IL4R, MAPKAPK2, arthritis PLAU*, SOCS3*, TNF dermatitis 5.28E-5 - 5.28E-5 9 dermatitis 0.0000528 9 CASP1*, DAF*, IFNGR2, IL1A, IL1B*, IL4R, NFKBIA*, PRKR, TNF systemic lupus erythematosus 1.40E-4 - 1.40E-4 7 systemic lupus erythematosus 0.00014 7 ICAM1, LYN, PTPNS1*, PTPRC, TNF, TNFRSF6, TNFSF13B* nephritis 3.36E-4 - 3.36E-4 8 CCR1*, FCGR2B*, IFNGR1, LYN, NFKBIA*, PTPRC, TNFRSF6, nephritis 0.000336 8 TNFSF13B* glomerulonephritis 5.35E-4 - 5.35E-4 7

glomerulonephritis 0.000535 7 CCR1*, FCGR2B*, IFNGR1, LYN, NFKBIA*, TNFRSF6, TNFSF13B* insulitis 8.28E-4 - 8.28E-4 5 insulitis 0.000828 5 CCL3, ICAM1, IFNGR1, TNF, TNFRSF6 lupus nephritis 1.32E-3 - 1.32E-3 4 lupus nephritis 0.00132 4 FCGR2B*, LYN, PTPRC, TNFRSF6 encephalitis 2.86E-3 - 2.86E-3 2 encephalitis 0.00286 2 ALOX5*, NFKB2* Cellular Movement 6.19E-10 - 3.94E-3 84 cell movement 6.19E-10 - 3.16E-3 82 ALOX5AP, ANXA1, CAMP, CASP1*, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCER1G, FPR1, GSN, ICAM1, IL1B*, IL4R, cell movement of bone 6.19E-10 30 IL8*, IL8RA, ITGAM*, JAK2*, MAPK14*, MAPKAPK2, MMP9, OSM*, marrow cells PIK3CG, PLAU*, PTPNS1*, SELL, TNF, TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCAR*, FCER1G, FCGR2B*, FPR1, FPRL1*, FYB*, GSN, HGF, ICAM1, IL1B*, IL4R, IL8*, IL8RA, 1.53E-09 44 ITGAM*, JAK3*, LYN, MAPK14*, MAPKAPK2, MMP9, OSM*, cell movement of blood PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, STAT3, cells TLR4*, TNF, TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCAR*, FCER1G, FPR1, FPRL1*, GSN, HGF, 2.02E-09 32 ICAM1, IL1B*, IL8*, IL8RA, ITGAM*, MAPK14*, MAPKAPK2, cell movement of PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, SELL, TNF, TNFRSF6, phagocytes TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCER1G, FPR1, GSN, ICAM1, IL1B*, IL4R, cell movement of 2.51E-09 28 IL8*, IL8RA, ITGAM*, MAPK14*, MAPKAPK2, OSM*, PIK3CG, granulocytes PLAU*, PTPNS1*, SELL, TNF, TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCER1G, FCGR2B*, FPR1, FPRL1*, FYB*, GSN, HGF, ICAM1, IL1B*, IL4R, IL8*, IL8RA, 3.33E-09 42 ITGAM*, LYN, MAPK14*, MAPKAPK2, MMP9, OSM*, PIK3CG, cell movement of PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, STAT3, TLR4*, TNF, leukocytes TNFRSF6, TXN* ALOX5AP, ANXA1, CAMP, CASP1*, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCAR*, FCER1G, FPR1, FPRL1*, FYB*, GSN, HGF, ICAM1, IL1A, IL1B*, IL4R, IL8*, IL8RA, 1.06E-08 41 ITGAM*, JAK2*, MAPK14*, MAPKAPK2, MMP9, OSM*, PIK3CG, cell movement of PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, TNF, TNFRSF6, lymphatic system cells TXN* CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL2*, FCAR*, FPR1, FPRL1*, GSN, HGF, ICAM1, IL1A, IL1B*, IL8RA, cell movement of 1.19E-08 26 MAPK14*, PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, antigen presenting cells TNF ALOX5AP, ANXA1, CAMP, CASP1*, CCL3, CCL4, CXCL2*, FCER1G, FPR1, GSN, ICAM1, IL1B*, IL8*, IL8RA, ITGAM*, cell movement of 1.24E-08 23 MAPK14*, MAPKAPK2, PIK3CG, PLAU*, SELL, TNF, TNFRSF6, neutrophils TXN* CAMP, CCL20, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FCAR*, cell movement of 0.000000072 22 FPR1, FPRL1*, GSN, HGF, ICAM1, IL8RA, MAPK14*, PIK3CG, macrophages PLAU*, PLAUR*, PTPNS1*, REN, SELL, TNF ADM, ALOX5AP, ANXA1, BAL, BMX, CAMP, CASP1 , CCL20, CCL3, CCL4, CCR1*, CD24*, CD44*, CEACAM1*, CLIC4*, CTSB*, CXCL16, CXCL2*, DGKA*, EDN1, ETS2*, FCAR*, FCER1G, FCGR2B*, FPR1, FPRL1*, FYB*, GPR132, GRID2, GSN, HGF, HHEX, HMGB2, ICAM1, IGF1R, IGHG1*, IL1A, IL1B*, IL4R, IL8*, IL8RA, ITGAM*, 0.000000124 82 JAK2*, JAK3*, LGALS8*, LYN, MAD*, MAPK14*, MAPKAPK2, MARCKS*, MMP9, OSM*, PIK3CG, PLAU*, PLAUR*, PRKCG, PROK2, PSEN1, PTEN, PTP4A1, PTPNS1*, PTPRO, REN, REPS2, S100A4, SCN1B, SDCBP, SELL, SEMA4F, SOCS3*, SORT1*, SPP1, ST14, STAT3, TCF3*, TFF3, TGFA, TLR4*, TNF, TNFRSF6, TXN*, cell movement WARS cell movement of CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, FPR1, ICAM1, dendritic cells 0.000000456 14 IL1A, IL1B*, IL8RA, REN, SPP1, TNF CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL2*, FCAR*, FPR1, FPRL1*, GSN, HGF, ICAM1, IL1B*, IL8*, IL8RA, LYN, cell movement of 0.00000165 28 MAPK14*, MAPKAPK2, PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, connective tissue cells SELL, SPP1, TNF CCL3, CCL4, CD24*, CD44*, CTSB*, EDN1, FPRL1*, GPR132, HGF, IGF1R, IL8*, IL8RA, ITGAM*, JAK2*, MMP9, OSM*, PLAU*, PLAUR*, cell movement of tumor 0.00000281 27 PRKCG, PTEN, PTPNS1*, S100A4, SDCBP, SELL, SPP1, STAT3, cell lines TGFA cell movement of T 0.00000307 18 CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, lymphocytes FYB*, HGF, ICAM1, IL8*, PLAU*, REN, SELL, SPP1, TNF, TNFRSF6 CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FPR1, FPRL1*, FYB*, HGF, ICAM1, IL8*, IL8RA, MAPK14*, cell movement of 0.00000345 27 MMP9, PIK3CG, PLAU*, PLAUR*, PTPNS1*, REN, SELL, SPP1, mononuclear leukocytes TNF, TNFRSF6 cell movement of CAMP, CCL20, CCL3, CCL4, CCR1*, CEACAM1*, CXCL2*, FPR1, monocytes 0.0000165 16 FPRL1*, HGF, IL8RA, MAPK14*, PLAUR*, PTPNS1*, REN, TNF cell movement of CCL3, CCL4, CCR1*, FPR1, IL1B*, IL4R, IL8*, MAPK14*, OSM*, eosinophils 0.0000211 12 PTPNS1*, TNF, TXN* cell movement of gonadal cell lines 0.0000678 9 CCL3, CCL4, CCR1*, EDN1, IL8*, PTP4A1, PTPNS1*, REPS2, SPP1 cell movement of CCL4, CD44*, FPRL1*, GPR132, HGF, ICAM1, IL8*, IL8RA, ITGAM*, leukocyte cell lines 0.0000731 16 JAK2*, MMP9, PLAU*, PLAUR*, PTPRO, SELL, TNF cell movement of peripheral blood 0.0000755 6 leukocytes CCL3, CCL4, FPR1, FPRL1*, PLAUR*, SELL CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, cell movement of 0.0000937 20 FYB*, HGF, ICAM1, IL8*, MMP9, PIK3CG, PLAU*, REN, SELL, lymphocytes SPP1, TNF, TNFRSF6 cell movement of CAMP, CCL20, CCR1*, FPRL1*, HGF, IGF1R, ITGAM*, OSM*, epithelial cell lines 0.000173 13 PLAU*, PLAUR*, SDCBP, STAT3, TGFA cell movement of ADM, HGF, IL1A, IL1B*, ITGAM*, MAPKAPK2, MMP9, PLAU*, smooth muscle cells 0.000212 11 PLAUR*, SPP1, TNF cell movement of breast CD44*, HGF, IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, cell lines 0.00118 10 STAT3, TGFA cell movement of naive lymphocytes 0.00132 4 CCL20, CCL4, SELL, TNF cell movement of PBMC cells 0.0027 3 CCL20, CCL3, CCL4 cell movement of hairy leukemia cells 0.00286 2 CD44*, IL8* cell movement of breast cancer cell lines 0.00316 8 IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, STAT3, TGFA infiltration 8.29E-9 - 8.28E-4 23 infiltration of 8.29E-09 16 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CXCL2*, FCER1G, granulocytes ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, FCAR*, 3.03E-08 23 FCER1G, FCGR2B*, ICAM1, IL4R, IL8*, JAK3*, MAPK14*, OSM*, infiltration of blood cells PIK3CG, PLAU*, REN, SELL, STAT3, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CXCL2*, FCAR*, FCER1G, 9.76E-08 16 ICAM1, IL8*, MAPK14*, PIK3CG, PLAU*, REN, SELL, TNF, infiltration of phagocytes TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CXCL2*, FCER1G, ICAM1, IL8*, infiltration of neutrophils 0.000000111 13 MAPK14*, PIK3CG, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, FCAR*, infiltration of lymphatic 0.00000029 20 FCER1G, ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, PLAU*, system cells REN, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, 0.000000405 20 FCER1G, FCGR2B*, ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, infiltration of leukocytes REN, SELL, STAT3, TNF, TNFRSF6 infiltration of macrophages 0.000326 7 CCL3, CCL4, FCAR*, ICAM1, PLAU*, REN, SELL infiltration of eosinophils 0.000828 5 CCL3, CCR1*, IL4R, MAPK14*, OSM* migration 9.86E-9 - 3.59E-3 59 ANXA1, CCL3, CCL4, CEACAM1*, FPR1, ICAM1, IL1B*, IL8*, migration of bone 9.86E-09 18 ITGAM*, JAK2*, MAPKAPK2, MMP9, PLAU*, PTPNS1*, SELL, TNF, marrow cells TNFRSF6, TXN* ANXA1, CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, CXCL2*, FCER1G, FPR1, FPRL1*, FYB*, HGF, ICAM1, 8.07E-08 33 IL1B*, IL8*, IL8RA, ITGAM*, LYN, MAPK14*, MAPKAPK2, MMP9, PIK3CG, PLAU*, PLAUR*, PTPNS1*, SELL, SPP1, TNF, TNFRSF6, migration of leukocytes TXN* ANXA1, CCL3, CCL4, CEACAM1*, FPR1, ICAM1, IL1B*, IL8*, migration of 9.76E-08 16 ITGAM*, MAPKAPK2, PLAU*, PTPNS1*, SELL, TNF, TNFRSF6, granulocytes TXN* ANXA1, CCL20, CCL3, CEACAM1*, FPR1, HGF, ICAM1, IL1B*, IL8*, 0.000000226 18 ITGAM*, MAPK14*, MAPKAPK2, PLAU*, PTPNS1*, SELL, TNF, migration of phagocytes TNFRSF6, TXN* ANXA1, CCL20, CCL3, CCL4, CD44*, CEACAM1*, FPR1, FYB*, migration of lymphatic 0.000000724 24 HGF, ICAM1, IL1B*, IL8*, ITGAM*, JAK2*, MAPK14*, MAPKAPK2, system cells MMP9, PLAU*, PTPNS1*, SELL, SPP1, TNF, TNFRSF6, TXN* ANXA1, FPR1, ICAM1, IL1B*, IL8*, ITGAM*, MAPKAPK2, PLAU*, migration of neutrophils 0.00000122 12 SELL, TNF, TNFRSF6, TXN* migration of T CCL20, CCL3, CCL4, CD44*, CEACAM1*, FYB*, HGF, ICAM1, lymphocytes 0.0000624 11 PLAU*, SPP1, TNF ADM, ANXA1, BAL, BMX, CAMP, CCL20, CCL3, CCL4, CCR1 , CD44*, CEACAM1*, CLIC4*, CXCL16, CXCL2*, EDN1, ETS2*, FCER1G, FPR1, FPRL1*, FYB*, GPR132, HGF, HHEX, ICAM1, IGF1R, IGHG1*, IL1A, IL1B*, IL8*, IL8RA, ITGAM*, JAK2*, LYN, 0.0000718 59 MAD*, MAPK14*, MAPKAPK2, MARCKS*, MMP9, OSM*, PIK3CG, PLAU*, PLAUR*, PSEN1, PTEN, PTPNS1*, REPS2, SDCBP, SELL, SEMA4F, SORT1*, SPP1, ST14, STAT3, TCF3*, TGFA, TNF, migration TNFRSF6, TXN*, WARS migration of dendritic cells 0.000136 9 CCL20, CCL3, CCL4, CD44*, CEACAM1*, ICAM1, IL1B*, SPP1, TNF migration of 0.000218 14 CCL20, CCL3, CCL4, CD44*, CEACAM1*, FYB*, HGF, ICAM1, IL8*, mononuclear leukocytes MAPK14*, PLAU*, PTPNS1*, SPP1, TNF migration of tumor cell 0.000228 17 CD44*, EDN1, GPR132, HGF, IGF1R, IL8*, ITGAM*, JAK2*, MMP9, lines OSM*, PLAU*, PLAUR*, PTEN, PTPNS1*, SDCBP, SPP1, TGFA migration of CCL20, CCL3, CCL4, CD44*, CEACAM1*, FYB*, HGF, ICAM1, IL8*, lymphocytes 0.00026 12 PLAU*, SPP1, TNF migration of smooth ADM, HGF, IL1A, IL1B*, ITGAM*, MAPKAPK2, MMP9, PLAU*, SPP1, muscle cells 0.000309 10 TNF migration of antigen CCL20, CCL3, CCL4, CD44*, CEACAM1*, HGF, ICAM1, IL1B*, presenting cells 0.000392 12 MAPK14*, PTPNS1*, SPP1, TNF migration of Langerhans cells 0.000479 4 CCL20, CD44*, ICAM1, SPP1 migration of vascular smooth muscle cells 0.000622 6 ADM, HGF, IL1A, IL1B*, PLAU*, TNF migration of nervous tissue cell lines 0.00103 7 HGF, MMP9, PLAU*, PLAUR*, PTEN, PTPNS1*, SORT1* migration of brain cancer cell lines 0.00106 6 HGF, MMP9, PLAU*, PLAUR*, PTEN, PTPNS1* migration of epithelial CCL20, CCR1*, FPRL1*, IGF1R, ITGAM*, PLAU*, PLAUR*, SDCBP, cell lines 0.00157 9 TGFA migration of embryonic cell lines 0.0021 6 CCL20, CCR1*, FPRL1*, ITGAM*, PLAU*, PLAUR* migration of eosinophils 0.00268 5 CCL4, IL1B*, PTPNS1*, TNF, TXN* migration of astrocytes 0.00286 2 CCL3, HGF migration of epithelial cells 0.00314 6 HGF, ICAM1, MMP9, SELL, STAT3, TCF3* migration of breast cancer cell lines 0.00359 7 IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, TGFA chemokinesis 2.48E-6 - 2.48E-6 5 chemokinesis of neutrophils 0.00000248 5 CCL3, CCL4, CXCL2*, IL8*, TNF invasion 7.89E-6 - 2.85E-3 27

CD44*, CTSB*, EDN1, ETS2*, GRID2, GSN, HGF, HHEX, HIF1A, 0.00000789 26 IGF1R, IGHG1*, IL8*, JAK2*, MMP9, MYCN, OSM*, PLAU*, PLAUR*, invasion of cells PTEN, PTP4A1, S100A4, SDCBP, SPP1, TCF3*, TFF3, TNF invasion of tumor cell 0.0000217 18 CD44*, CTSB*, EDN1, ETS2*, HGF, HIF1A, IGF1R, MMP9, MYCN, lines PLAU*, PLAUR*, PTEN, S100A4, SDCBP, SPP1, TFF3, TGFA, TNF invasion of gonadal cell lines 0.00025 4 EDN1, PLAU*, PTP4A1, TNF invasion of nervous tissue cell lines 0.000341 6 CTSB*, IGF1R, MMP9, MYCN, PLAUR*, PTEN invasion of ovarian cancer cell lines 0.000587 3 EDN1, PLAU*, TNF invasion of brain cancer cell lines 0.00156 5 CTSB*, IGF1R, MMP9, PLAUR*, PTEN invasion of prostate cancer cell lines 0.00285 4 CTSB*, ETS2*, PLAUR*, PTEN chemotaxis 2.96E-5 - 1.98E-3 32 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, CXCL2*, FCER1G, chemotaxis of 0.0000296 22 FPR1, FPRL1*, IL1B*, IL8*, IL8RA, ITGAM*, LYN, MMP9, PIK3CG, leukocytes PLAU*, PLAUR*, SPP1, TNF, TXN* chemotaxis of peripheral blood 0.0000869 5 monocytes CCL3, CCL4, FPR1, FPRL1*, PLAUR*

CAMP, CCL20, CCL3, CCL4, CCR1*, CD44*, CEACAM1*, CXCL16, 0.0000881 32 CXCL2*, FCER1G, FPR1, FPRL1*, HGF, IL1A, IL1B*, IL8*, IL8RA, ITGAM*, LYN, MAPK14*, MMP9, PIK3CG, PLAU*, PLAUR*, PRKCG, chemotaxis PROK2, PTEN, SCN1B, SOCS3*, SPP1, TNF, TXN* chemotaxis of CAMP, CCL3, CCL4, CXCL2*, FCER1G, FPR1, IL1B*, IL8*, IL8RA, neutrophils 0.000168 12 ITGAM*, PIK3CG, TNF CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, CXCL2*, FCER1G, chemotaxis of lymphatic 0.000279 20 FPR1, FPRL1*, IL1A, IL1B*, IL8*, IL8RA, ITGAM*, MMP9, PIK3CG, system cells PLAUR*, SPP1, TNF chemotaxis of dendritic cells 0.000326 7 CCL20, CCL3, CCL4, FPR1, IL1A, IL1B*, TNF chemotaxis of T lymphocytes 0.000738 9 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, IL8*, SPP1, TNF

chemotaxis of 0.00123 14 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, FPR1, FPRL1*, IL8*, mononuclear leukocytes MMP9, PIK3CG, PLAUR*, SPP1, TNF chemotaxis of CAMP, CCL3, CCL4, CXCL2*, FCER1G, FPR1, FPRL1*, IL1B*, IL8*, phagocytes 0.00123 14 IL8RA, ITGAM*, PIK3CG, PLAUR*, TNF chemotaxis of CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, IL8*, MMP9, PIK3CG, lymphocytes 0.00143 11 SPP1, TNF chemotaxis of antigen CAMP, CCL20, CCL3, CCL4, FPR1, FPRL1*, IL1A, IL1B*, PIK3CG, presenting cells 0.00161 11 PLAUR*, TNF chemotaxis of CAMP, CCL3, CCL4, FPR1, FPRL1*, HGF, IL1B*, LYN, PIK3CG, connective tissue cells 0.00161 12 PLAU*, PLAUR*, TNF chemotaxis of gonadal cell lines 0.00198 4 CCL3, CCL4, CCR1*, IL8* extravasation 1.88E-4 - 1.88E-4 7 extravasation 0.000188 7 ALOX5AP, CCR1*, IL1B*, IL8RA, ITGAM*, SELL, TNF rolling 5.10E-4 - 1.84E-3 8 rolling of blood cells 0.00051 8 CD44*, ICAM1, IL1B*, IL8RA, ITGAM*, SELL, TLR4*, TNF rolling of leukocytes 0.00184 7 ICAM1, IL1B*, IL8RA, ITGAM*, SELL, TLR4*, TNF transmigration 5.35E-4 - 3.94E-3 7 transmigration of leukocytes 0.000535 7 CCL3, CCL4, FPR1, IL1B*, IL8*, PTPNS1*, TNF transmigration of lymphatic system cells 0.0021 6 CCL3, CCL4, FPR1, IL8*, PTPNS1*, TNF transmigration of phagocytes 0.00268 5 CCL3, FPR1, IL8*, PTPNS1*, TNF transmigration of granulocytes 0.00394 4 FPR1, IL8*, PTPNS1*, TNF influx 5.77E-4 - 5.77E-4 5 influx of leukocytes 0.000577 5 CCL3, CCL4, CXCL2*, MMP9, TNF emigration 2.85E-3 - 2.85E-3 4

emigration of leukocytes 0.00285 4 ANXA1, CD44*, SELL, SPP1 Tissue Morphology 2.39E-9 - 3.55E-3 72 quantity 2.39E-9 - 2.86E-3 68 BCL2A1, BST1, CCL3, CD24 , CD59 , FCGR1A , FES, HIF1A, ICAM1, IFNAR1, IFNGR1, IGF1R, IL1A, IL1B*, IL4R, IL8*, ITGAM*, JAK2*, JAK3*, KL, LGALS8*, LYN, MAD*, MAPK14*, MLLT2*, 2.39E-09 51 MMP9, MYB, NFKB2*, NFKBIA*, OSM*, PIK3AP1, PIK3CG, PLAU*, PLSCR1*, PML*, PTCRA, PTEN, PTPN2, PTPRC, REN, SELL, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, THRA, TLR4*, TNF, quantity of blood cells TNFRSF6, TNFSF13B* BCL2A1, BST1, CD24*, FCGR1A*, FES, HIF1A, ICAM1, IFNAR1, IFNGR1, IGF1R, IL1A, IL1B*, IL8*, JAK2*, JAK3*, KL, LGALS8*, LYN, MAD*, MLLT2*, MMP9, NFKB2*, NFKBIA*, OSM*, PIK3AP1, 1.33E-08 44 PIK3CG, PLSCR1*, PML*, PTCRA, PTEN, PTPN2, PTPRC, REN, SELL, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, THRA, TLR4*, TNF, quantity of leukocytes TNFRSF6, TNFSF13B* BST1, CCL3, CD24*, FCGR1A*, FES, HIF1A, ICAM1, IFNAR1, IFNGR1, IGF1R, IL1A, IL1B*, IL8*, JAK2*, JAK3*, KL, LGALS8*, LYN, MAD*, MLLT2*, MMP9, NFKB2*, NFKBIA*, OSM*, PIK3AP1, 4.69E-08 45 PIK3CG, PLAU*, PLSCR1*, PML*, PTCRA, PTEN, PTPN2, PTPRC, quantity of lymphatic REN, SELL, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, THRA, system cells TLR4*, TNF, TNFRSF6, TNFSF13B* CCL3, FCGR1A*, ICAM1, IFNAR1, IFNGR1, IL1A, IL1B*, IL8*, 0.00000012 20 JAK3*, MMP9, PIK3CG, PLAU*, PLSCR1*, PML*, REN, SELL, quantity of phagocytes THRA, TLR4*, TNF, TNFRSF6 BST1, CD24*, HIF1A, ICAM1, IFNAR1, IFNGR1, IGF1R, IL1A, IL8*, JAK2*, JAK3*, KL, LGALS8*, LYN, MLLT2*, MMP9, NFKB2*, 0.000000178 37 NFKBIA*, OSM*, PIK3AP1, PIK3CG, PML*, PTCRA, PTEN, PTPN2, quantity of mononuclear PTPRC, REN, SELL, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, leukocytes THRA, TNF, TNFRSF6, TNFSF13B* BST1, CD24*, HIF1A, ICAM1, IFNAR1, IFNGR1, IGF1R, JAK2*, JAK3*, KL, LGALS8*, LYN, MLLT2*, NFKB2*, NFKBIA*, OSM*, 0.00000345 33 PIK3AP1, PIK3CG, PTCRA, PTEN, PTPN2, PTPRC, REN, SELL, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, THRA, TNF, TNFRSF6, quantity of lymphocytes TNFSF13B* FCGR1A*, ICAM1, IL1B*, JAK3*, PIK3CG, PLSCR1*, PML*, SELL, quantity of neutrophils 0.00000393 11 TLR4*, TNF, TNFRSF6 quantity of CCL3, ICAM1, IFNAR1, IFNGR1, IL1A, IL1B*, IL8*, MMP9, PIK3CG, macrophages 0.00000465 15 PLAU*, PML*, REN, SELL, THRA, TNF BCL2A1, CCL3, GGT1, ICAM1, IFNAR1, IFNGR1, IL1A, IL1B*, quantity of connective 0.0000102 22 IL1RN*, IL8*, JAK3*, KL, MMP9, NFKB2*, PIK3CG, PLAU*, PML*, tissue cells REN, SELL, SPP1, THRA, TNF FCGR1A*, FES, ICAM1, IL1A, IL1B*, IL8*, JAK3*, MAD*, PIK3CG, quantity of myeloid cells 0.0000122 16 PLSCR1*, PML*, SELL, THRA, TLR4*, TNF, TNFRSF6 quantity of antigen CCL3, ICAM1, IFNAR1, IFNGR1, IL1A, IL1B*, IL8*, MMP9, NFKB2*, presenting cells 0.0000165 16 PIK3CG, PLAU*, PML*, REN, SELL, THRA, TNF ADM, BCL2A1, BMP2, BST1, CCL3, CD24 , CD59 , EDN1, FCGR1A*, FES, GGT1, GPR41, GSN, HGF, HIF1A, ICAM1, IFNAR1, IFNGR1, IGF1R, IGFBP5, IL1A, IL1B*, IL1RN*, IL4R, IL8*, ITGAM*, JAK2*, JAK3*, KL, LGALS8*, LYN, MAD*, MAPK14*, MLLT2*, 0.0000252 68 MMP9, MUSK, MYB, NFKB2*, NFKBIA*, NTRK3, OSM*, PIK3AP1, PIK3CG, PLAU*, PLAUR*, PLSCR1*, PML*, PSEN1, PTCRA, PTEN, PTPN2, PTPRC, REN, SELL, SOCS3*, SOD2*, SPP1, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, TGFA, THRA, TLR4*, TNF, quantity of cells TNFRSF6, TNFSF13B* FCGR1A*, ICAM1, IL1A, IL1B*, IL8*, JAK3*, PIK3CG, PLSCR1*, quantity of granulocytes 0.000042 14 PML*, SELL, THRA, TLR4*, TNF, TNFRSF6 ICAM1, IFNAR1, IFNGR1, IGF1R, JAK2*, JAK3*, LGALS8*, MLLT2*, NFKBIA*, OSM*, PIK3CG, PTCRA, PTEN, PTPRC, REN, STAT3, quantity of T 0.000047 24 STAT5A, STAT5B*, TAL1, TCF3*, THRA, TNF, TNFRSF6, lymphocytes TNFSF13B* quantity of B 0.000048 17 BST1, CD24*, HIF1A, JAK3*, KL, LYN, MLLT2*, NFKB2*, PIK3AP1, lymphocytes PTEN, PTPN2, STAT5A, STAT5B*, TCF3*, THRA, TNF, TNFSF13B* quantity of osteoclasts 0.000817 6 GGT1, IL1A, IL1RN*, KL, SPP1, TNF quantity of osteocytes 0.00126 7 GGT1, IL1A, IL1RN*, KL, NFKB2*, SPP1, TNF quantity of monocytes 0.00135 6 ICAM1, IL1A, IL8*, PIK3CG, PML*, SELL quantity of monocyte- derived macrophage 0.00286 2 cells IL1A, NFKBIA* destruction 1.52E-4 - 2.86E-3 5 destruction of connective tissue 0.000152 5 IL1A, IL1B*, IL8*, NFKBIA*, OSM* destruction of cartilage tissue 0.0027 3 IL1A, IL1B*, OSM* destruction of synovial membrane 0.00286 2 IL8*, NFKBIA* thickness 1.53E-4 - 1.53E-4 3 thickness of trabecular bone 0.000153 3 GSN, IGFBP5, NPY2R remodeling 2.32E-3 - 3.55E-3 14 ALPL, BMP2, BMPR2, GGT1, GSN, IL1A, KL, MMP9, NPY2R, OSM*, remodeling of tissue 0.00232 14 SPP1, TAL1, THRA, TNF ALPL, BMP2, BMPR2, GGT1, GSN, IL1A, KL, MMP9, NPY2R, OSM*, remodeling of bone 0.00355 13 SPP1, THRA, TNF resorption 2.60E-3 - 2.60E-3 7 resorption of bone 0.0026 7 GGT1, GSN, IL1A, KL, OSM*, SPP1, TNF thickening 2.86E-3 - 2.86E-3 2 thickening of tissue 0.00286 2 IL1B*, TXN* Cell Death 2.56E-9 - 3.94E-3 144 cell death 2.56E-9 - 3.94E-3 131 cell death of endothelial ADM, ATF3, BCL2A1, CASP1*, CD59*, HGF, IL1B*, IL8*, MAPK14*, cell lines 2.56E-09 14 MYB, PTEN, SPP1, TNF, TNFRSF6 BCL2A1, CASP1*, CD44*, GSN, IL1B*, IL1RN*, IL8*, ITGAM*, cell death of bone 3.41E-09 18 JAK2*, LYN, MAPK14*, PML*, PRKCD, SPP1, STAT5A, STAT5B*, marrow cells TNF, TNFRSF6 ACVR1B , ADM, ADORA2A, ALOX5 , ATF3, BCL2A1, BMP2, BMX, BTG2*, CASP1*, CD24*, CD44*, CD59*, CFLAR*, CTSB*, DAF*, EDN1, ETS2*, FGR, G6PD, GADD45B*, GGT1, GSN, HGF, HIP1*, HSPA1A*, HSXIAPAF1*, IER3, IFNAR1, IGF1R, IGFBP5, IL1A, 6.60E-09 65 IL1B*, IL1RN*, ITGAM*, LMNB1, LYN, MAD*, MAPK14*, MYB, MYCN, NFIL3, NFKBIA*, PML*, PPP1R15A*, PRKCD, PRKR, PSEN1, PTCRA, PTEN, PTPNS1*, PTPRC, SLC5A5, SOCS3*, cell death of tumor cell SOD2*, STAT3, TAL1, TCF3*, TFF3, TGFA, TNF, TNFAIP3*, lines TNFRSF6, TXN*, UGCG* ACVR1B*, ADM, ADORA2A, ALOX5*, ARG1, ATF3, ATF6*, BCL2A1, BCL3*, BMP2, BMX, BPI, BTG2*, BZRP, CASP1*, CASP5, CCL3, CCL4, CD24*, CD44*, CD53, CD59*, CFLAR*, CLCN2, CLIC4*, CREM*, CSPG2*, CTSB*, DAF*, DSIPI*, EDN1, ERN1, ETS2*, FACL4, FCAR*, FCGR1A*, FCGR2B*, FGR, G6PD, GADD45B*, GGT1, GPR41, GRID2, GSN, GULP1, HGF, HIF1A, HIP1*, HSPA1A*, HSXIAPAF1*, ICAM1, IER3, IFNAR1, IGF1R, IGFBP5, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, ITGAM*, IVNS1ABP*, 1.28E-08 131 JAK2*, KIF1B*, LDHA, LMNB1, LYN, MAD*, MAIL, MAPK14*, MMP9, MYB, MYCN, MYOD1, NBS1*, NFIL3, NFKBIA*, NTRK3, OSM*, PDCD1LG1*, PDCD4*, PEG10, PGLYRP, PIK3CG, PLAU*, PLSCR1*, PML*, PPP1R15A*, PPP2R5A, PRKCD, PRKCG, PRKR, PROK2, PSEN1, PTCRA, PTEN, PTPNS1*, PTPRC, QKI, REN, RIPK2, RNASEL, S100A4, SCOTIN, SH3BP5*, SH3GLB1*, SLC5A5, SLK, SOCS3*, SOD2*, SP1, SPP1, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, TFDP1, TFF3, TGFA, TK1, TLR4*, TNF, TNFAIP3*, cell death TNFRSF6, TNFSF13B*, TXN*, UGCG*, XRCC4

BCL2A1, CASP1*, CCL3, CCL4, CD44*, CD59*, CFLAR*, ETS2*, FCAR*, FCGR2B*, GSN, ICAM1, IER3, IL1B*, IL1RN*, IL8*, ITGAM*, 2.38E-08 38 JAK2*, LYN, MAD*, MAPK14*, PDCD1LG1*, PIK3CG, PML*, PRKCD, PTEN, PTPRC, RNASEL, SH3BP5*, SOD2*, STAT3, cell death of blood cells STAT5A, STAT5B*, TCF3*, TLR4*, TNF, TNFRSF6, TNFSF13B* ATF6*, BCL2A1, BCL3*, BMP2, BMX, CD24*, CD44*, CD59*, CFLAR*, DAF*, FGR, GGT1, GSN, HGF, IFNAR1, IGF1R, IL9R, ITGAM*, JAK2*, LMNB1, LYN, MAD*, MAPK14*, MYB, NFIL3, 3.27E-08 43 NFKBIA*, PML*, PRKCD, PSEN1, PTCRA, PTEN, PTPRC, cell death of leukocyte SH3GLB1*, SPP1, STAT5A, TAL1, TCF3*, TFDP1, TGFA, TNF, cell lines TNFAIP3*, TNFRSF6, TXN* BCL2A1, CASP1*, CCL3, CCL4, CD44*, CFLAR*, ETS2*, FCAR*, FCGR2B*, GSN, ICAM1, IER3, IL1B*, IL1RN*, IL8*, ITGAM*, JAK2*, 3.58E-08 38 LYN, MAPK14*, PDCD1LG1*, PIK3CG, PML*, PRKCD, PTEN, cell death of lymphatic PTPRC, RNASEL, SH3BP5*, SOD2*, SPP1, STAT3, STAT5A, system cells STAT5B*, TCF3*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* cell death of BCL2A1, CASP1*, GSN, IL1B*, IL1RN*, IL8*, ITGAM*, JAK2*, LYN, granulocytes 3.96E-08 13 MAPK14*, PRKCD, TNF, TNFRSF6 BCL2A1, CASP1*, GSN, IL1B*, IL1RN*, IL8*, MAPK14*, PRKCD, cell death of neutrophils 0.000000278 10 TNF, TNFRSF6 BCL2A1, CASP1*, CCL3, CCL4, CD44*, CD59*, CFLAR*, ETS2*, FCAR*, FCGR2B*, GSN, ICAM1, IER3, IL1B*, IL1RN*, IL8*, ITGAM*, 0.000000425 33 JAK2*, LYN, MAPK14*, PDCD1LG1*, PIK3CG, PRKCD, PTEN, PTPRC, RNASEL, SH3BP5*, STAT3, STAT5B*, TCF3*, TNF, cell death of leukocytes TNFRSF6, TNFSF13B* cell death of prostate ALOX5*, BMX, CASP1*, CFLAR*, EDN1, ETS2*, IGFBP5, PRKCD, cancer cell lines 0.00000118 15 PTEN, SLC5A5, STAT3, TGFA, TNF, TNFRSF6, TXN* ADORA2A, ATF3, BTG2*, CASP1*, CFLAR*, G6PD, HGF, IGF1R, cell death of endocrine 0.00000165 17 IL1B*, IL1RN*, MAPK14*, NFKBIA*, SOCS3*, SOD2*, TK1, TNF, cell lines TNFRSF6 BCL2A1, CASP1*, CFLAR*, GSN, IL1B*, IL1RN*, IL8*, MAPK14*, cell death of phagocytes 0.00000188 14 PRKCD, PTEN, SOD2*, TLR4*, TNF, TNFRSF6 cell death of prostate ALOX5*, BMX, CASP1*, CFLAR*, EDN1, ETS2*, IGFBP5, PRKCD, cell lines 0.00000264 15 PTEN, SLC5A5, STAT3, TGFA, TNF, TNFRSF6, TXN* cell death of brain CASP1*, CD59*, CFLAR*, HGF, HIP1*, IGF1R, PRKCD, PSEN1, cancer cell lines 0.00000906 12 PTEN, PTPNS1*, TNF, TNFRSF6 CFLAR*, EDN1, ETS2*, HSPA1A*, HSXIAPAF1*, IER3, IL1A, IL1B*, cell death of cell lines 0.0000245 15 PML*, PRKR, TCF3*, TFF3, TNF, TNFRSF6, TXN* BCL2A1, CASP1*, CCL3, CCL4, CD44*, CD59*, CFLAR*, ETS2*, FCAR*, FCGR2B*, ICAM1, IER3, IL1B*, PDCD1LG1*, PIK3CG, cell death of 0.000158 25 PTEN, PTPRC, RNASEL, SH3BP5*, STAT3, STAT5B*, TCF3*, TNF, mononuclear leukocytes TNFRSF6, TNFSF13B* cell death of pancreatic cancer cell lines 0.00017 6 HGF, IGF1R, IL1B*, SOCS3*, TNF, TNFRSF6 cell death of T cell blasts 0.00025 4 CCL3, CCL4, CD59*, TNFRSF6 cell death of lymphoma BCL2A1, BMP2, BMX, CD24*, CD59*, CFLAR*, DAF*, GGT1, cell lines 0.000256 15 LMNB1, MAD*, NFKBIA*, PSEN1, PTPRC, TNF, TNFRSF6 BCL2A1, CASP1*, CCL3, CCL4, CD44*, CFLAR*, ETS2*, FCAR*, FCGR2B*, ICAM1, IER3, IL1B*, PDCD1LG1*, PIK3CG, PTEN, cell death of 0.000257 24 PTPRC, RNASEL, SH3BP5*, STAT3, STAT5B*, TCF3*, TNF, lymphocytes TNFRSF6, TNFSF13B* cell death of pheochromocytoma cell 0.000261 10 ADORA2A, ATF3, BTG2*, CASP1*, G6PD, IL1B*, IL1RN*, MAPK14*, lines NFKBIA*, SOD2* cell death of muscle ADM, BMP2, EDN1, HGF, IL1B*, MAPK14*, PRKCD, PTEN, cells 0.000392 12 SOCS3*, SP1, TNF, TNFRSF6 cell death of smooth muscle cells 0.000622 6 EDN1, IL1B*, PRKCD, SP1, TNF, TNFRSF6 cell death of nervous CASP1*, CD59*, CFLAR*, HGF, HIP1*, IGF1R, MYCN, PRKCD, tissue cell lines 0.000678 14 PSEN1, PTEN, PTPNS1*, TNF, TNFRSF6, TXN* BMP2, CASP1*, CD44*, CFLAR*, IGF1R, IL1A, IL1B*, MAPK14*, cell death of connective 0.000787 20 MMP9, PML*, PRKR, PTEN, QKI, RNASEL, SLK, SOD2*, TLR4*, tissue cells TNF, TNFRSF6, TXN* cell death of islet cells 0.00103 7 HGF, IGF1R, IL1B*, NFKBIA*, TNF, TNFRSF6, TXN* CD24*, CD59*, CFLAR*, FGR, GSN, IFNAR1, ITGAM*, LYN, cell death of leukemia 0.00105 18 MAPK14*, NFIL3, NFKBIA*, PML*, TAL1, TCF3*, TGFA, TNF, cell lines TNFAIP3*, TNFRSF6 cell death of beta islet cells 0.00169 6 HGF, IGF1R, IL1B*, TNF, TNFRSF6, TXN* CASP1*, CCL3, CCL4, CD44*, CFLAR*, ETS2*, ICAM1, IER3, IL1B*, cell death of T 0.00205 18 PDCD1LG1*, PIK3CG, PTEN, PTPRC, RNASEL, STAT5B*, TCF3*, lymphocytes TNF, TNFRSF6 cell death of B BCL2A1, CASP1*, CFLAR*, FCAR*, FCGR2B*, PTEN, SH3BP5*, lymphocytes 0.00279 10 TNF, TNFRSF6, TNFSF13B* cell death of eosinophils 0.00285 4 JAK2*, LYN, TNF, TNFRSF6 cell death of 0.00285 4 lymphoblastoid cell lines BMP2, NFKBIA*, TNF, TNFRSF6 cell death of colonocytes 0.00286 2 TFF3, TNF cell death of HC cells 0.00286 2 IER3, TNF cell death of large granular lymphocytes 0.00286 2 STAT3, TNFRSF6 cell death of pneumocytes 0.00286 2 PTEN, TNFRSF6 cell death of astrocytes 0.00394 4 EDN1, IL8*, TNF, TNFRSF6 death 7.54E-9 - 7.54E-9 132 ACVR1B*, ADM, ADORA2A, ALOX5*, ARG1, ATF3, ATF6*, BCL2A1, BCL3*, BMP2, BMX, BPI, BTG2*, BZRP, CASP1*, CASP5, CCL3, CCL4, CD24*, CD44*, CD53, CD59*, CFLAR*, CLCN2, CLIC4*, CREM*, CSPG2*, CTSB*, DAF*, DSIPI*, EDN1, ERN1, ETS2*, FACL4, FCAR*, FCGR1A*, FCGR2B*, FGR, FOSL2*, G6PD, GADD45B*, GGT1, GPR41, GRID2, GSN, GULP1, HGF, HIF1A, HIP1*, HSPA1A*, HSXIAPAF1*, ICAM1, IER3, IFNAR1, IGF1R, IGFBP5, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, ITGAM*, 7.54E-09 132 IVNS1ABP*, JAK2*, KIF1B*, LDHA, LMNB1, LYN, MAD*, MAIL, MAPK14*, MMP9, MYB, MYCN, MYOD1, NBS1*, NFIL3, NFKBIA*, NTRK3, OSM*, PDCD1LG1*, PDCD4*, PEG10, PGLYRP, PIK3CG, PLAU*, PLSCR1*, PML*, PPP1R15A*, PPP2R5A, PRKCD, PRKCG, PRKR, PROK2, PSEN1, PTCRA, PTEN, PTPNS1*, PTPRC, QKI, REN, RIPK2, RNASEL, S100A4, SCOTIN, SH3BP5*, SH3GLB1*, SLC5A5, SLK, SOCS3*, SOD2*, SP1, SPP1, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, TFDP1, TFF3, TGFA, TK1, TLR4*, TNF, death of cells TNFAIP3*, TNFRSF6, TNFSF13B*, TXN*, UGCG*, XRCC4 cell viability 3.31E-7 - 2.85E-3 19 cell viability of epithelial BCL2A1, CASP1*, HIP1*, NFKBIA*, SOD2*, TNF, TNFAIP3*, cell lines 0.000000331 9 TNFRSF6, UGCG* ADORA2A, BCL2A1, CASP1*, HGF, HIP1*, IGF1R, IL1B*, JAK2*, 0.000276 19 MYOD1, NFKBIA*, PRKCD, SOCS3*, SOD2*, TAL1, TNF, TNFAIP3*, cell viability of cells TNFRSF6, TNFSF13B*, UGCG* cell viability of tumor cell ADORA2A, BCL2A1, CASP1*, IL1B*, PRKCD, SOCS3*, SOD2*, lines 0.000783 10 TNF, TNFRSF6, UGCG* cell viability of embryonic cell lines 0.00141 3 HIP1*, NFKBIA*, TNFAIP3* cell viability of leukocyte cell lines 0.00169 6 BCL2A1, JAK2*, NFKBIA*, TAL1, TNF, TNFRSF6 cell viability of cervical cancer cell lines 0.00285 4 BCL2A1, CASP1*, SOD2*, TNFRSF6 cell viability of endocrine cell lines 0.00285 4 ADORA2A, IL1B*, SOCS3*, TNF cell viability of uterine cell lines 0.00285 4 BCL2A1, CASP1*, SOD2*, TNFRSF6 survival 1.75E-5 - 3.52E-3 46 ADORA2A, BCL2A1, BCL3*, BMP2, CCL3, CCR1*, CD44*, CR1*, HGF, IGF1R, IL1A, IL1B*, IL8*, JAK2*, JAK3*, KIF1B*, LYN, MAPK14*, MUSK, MYB, MYCN, MYOD1, NBS1*, NFE2, NFKBIA*, 0.0000175 45 NTRK3, OSM*, PLAU*, PLAUR*, PML*, PRKCD, PRKCG, PTEN, RNASEL, SOD2*, SPP1, STAT3, STAT5A, TCF3*, TGFA, TNF, survival of cells TNFRSF6, TNFSF13B*, TXN*, UGCG* survival of leukemia cell lines 0.000115 6 IL1A, LYN, PML*, TNF, TNFRSF6, TXN* survival of leukocyte BCL2A1, HGF, IL1A, JAK2*, LYN, MYB, NBS1*, PML*, STAT5A, cell lines 0.000392 12 TNF, TNFRSF6, TXN* survival of osteocytes 0.000577 5 BMP2, IGF1R, IL1A, IL1B*, TNF survival of tumor cell BCL2A1, DAF*, HGF, IL1A, LYN, NBS1*, PLAU*, PLAUR*, PML*, lines 0.00106 15 SOD2*, TCF3*, TNF, TNFRSF6, TXN*, UGCG* survival of neutrophils 0.00132 4 LYN, STAT3, TNF, TNFRSF6 survival of osteoclasts 0.00132 4 BMP2, IL1A, IL1B*, TNF survival of connective tissue cells 0.00136 9 BCL2A1, BMP2, IGF1R, IL1A, IL1B*, LYN, OSM*, TNF, TNFRSF6 survival of osteoclast- like cells 0.00286 2 IL1A, IL1B* BCL2A1, BCL3*, CR1*, IL8*, JAK3*, LYN, NFE2, STAT3, TCF3*, survival of blood cells 0.00352 12 TNF, TNFRSF6, TNFSF13B* cytotoxicity 4.49E-5 - 2.93E-3 18 CD44*, CD59*, CEACAM1*, CFLAR*, CYBB*, FGR, IFNAR1, 0.0000449 18 IFNGR2, LYN, NFKB2*, POR, PRKCD, SLAMF7*, STAT5B*, TNF, cytotoxicity of cells TNFAIP3*, TNFRSF6, TXN* cytotoxicity of blood CD44*, CD59*, CEACAM1*, CFLAR*, CYBB*, FGR, IFNAR1, cells 0.00094 13 IFNGR2, LYN, STAT5B*, TNF, TNFRSF6, TXN* cytotoxicity of macrophages 0.00198 4 CYBB*, FGR, LYN, TNF cytotoxicity of fibroblast cell lines 0.0027 3 NFKB2*, TNF, TNFAIP3* cytotoxicity of lymphatic CD44*, CEACAM1*, CFLAR*, CYBB*, FGR, IFNAR1, IFNGR2, LYN, system cells 0.00293 12 STAT5B*, TNF, TNFRSF6, TXN* self-renewal 1.41E-3 - 1.41E-3 3 self-renewal of multipotential hemopoietic progenitor 0.00141 3 cells JAK2*, STAT5A, STAT5B* cytolysis 3.39E-3 - 3.39E-3 11 CD44*, CD59*, CR1*, DAF*, FCAR*, FCGR1A*, IGHG1*, PTPRC, cytolysis 0.00339 11 SPP1, TNF, TNFRSF6 Cancer 6.60E-9 - 3.94E-3 123 cell death 6.60E-9 - 2.85E-3 65 ACVR1B , ADM, ADORA2A, ALOX5 , ATF3, BCL2A1, BMP2, BMX, BTG2*, CASP1*, CD24*, CD44*, CD59*, CFLAR*, CTSB*, DAF*, EDN1, ETS2*, FGR, G6PD, GADD45B*, GGT1, GSN, HGF, HIP1*, HSPA1A*, HSXIAPAF1*, IER3, IFNAR1, IGF1R, IGFBP5, IL1A, 6.60E-09 65 IL1B*, IL1RN*, ITGAM*, LMNB1, LYN, MAD*, MAPK14*, MYB, MYCN, NFIL3, NFKBIA*, PML*, PPP1R15A*, PRKCD, PRKR, PSEN1, PTCRA, PTEN, PTPNS1*, PTPRC, SLC5A5, SOCS3*, cell death of tumor cell SOD2*, STAT3, TAL1, TCF3*, TFF3, TGFA, TNF, TNFAIP3*, lines TNFRSF6, TXN*, UGCG* cell death of prostate ALOX5*, BMX, CASP1*, CFLAR*, EDN1, ETS2*, IGFBP5, PRKCD, cancer cell lines 0.00000118 15 PTEN, SLC5A5, STAT3, TGFA, TNF, TNFRSF6, TXN* cell death of brain CASP1*, CD59*, CFLAR*, HGF, HIP1*, IGF1R, PRKCD, PSEN1, cancer cell lines 0.00000906 12 PTEN, PTPNS1*, TNF, TNFRSF6 cell death of pancreatic cancer cell lines 0.00017 6 HGF, IGF1R, IL1B*, SOCS3*, TNF, TNFRSF6 cell death of lymphoma BCL2A1, BMP2, BMX, CD24*, CD59*, CFLAR*, DAF*, GGT1, cell lines 0.000256 15 LMNB1, MAD*, NFKBIA*, PSEN1, PTPRC, TNF, TNFRSF6 cell death of pheochromocytoma cell 0.000261 10 ADORA2A, ATF3, BTG2*, CASP1*, G6PD, IL1B*, IL1RN*, MAPK14*, lines NFKBIA*, SOD2* CD24*, CD59*, CFLAR*, FGR, GSN, IFNAR1, ITGAM*, LYN, cell death of leukemia 0.00105 18 MAPK14*, NFIL3, NFKBIA*, PML*, TAL1, TCF3*, TGFA, TNF, cell lines TNFAIP3*, TNFRSF6

cell death of 0.00285 4 lymphoblastoid cell lines BMP2, NFKBIA*, TNF, TNFRSF6 cell movement 2.81E-6 - 3.16E-3 27 CCL3, CCL4, CD24*, CD44*, CTSB*, EDN1, FPRL1*, GPR132, HGF, IGF1R, IL8*, IL8RA, ITGAM*, JAK2*, MMP9, OSM*, PLAU*, PLAUR*, cell movement of tumor 0.00000281 27 PRKCG, PTEN, PTPNS1*, S100A4, SDCBP, SELL, SPP1, STAT3, cell lines TGFA cell movement of hairy leukemia cells 0.00286 2 CD44*, IL8* cell movement of breast cancer cell lines 0.00316 8 IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, STAT3, TGFA adhesion 4.32E-6 - 2.70E-3 20 ANXA1, CCL3, CCL4, CD44*, CD59*, CSPG2*, DAF*, FES, HGF, adhesion of tumor cell 0.00000432 19 ICAM1, IGF1R, IL8*, ITGAM*, LGALS8*, PLAU*, PLAUR*, SPP1, lines TFF3, TNF adhesion of lymphoma cell lines 0.000244 6 ANXA1, CD59*, DAF*, ICAM1, ITGAM*, TNF adhesion of leukemia cells 0.0027 3 CD44*, ICAM1, SELL invasion 7.89E-6 - 2.85E-3 27

CD44*, CTSB*, EDN1, ETS2*, GRID2, GSN, HGF, HHEX, HIF1A, 0.00000789 26 IGF1R, IGHG1*, IL8*, JAK2*, MMP9, MYCN, OSM*, PLAU*, PLAUR*, invasion of cells PTEN, PTP4A1, S100A4, SDCBP, SPP1, TCF3*, TFF3, TNF invasion of tumor cell 0.0000217 18 CD44*, CTSB*, EDN1, ETS2*, HGF, HIF1A, IGF1R, MMP9, MYCN, lines PLAU*, PLAUR*, PTEN, S100A4, SDCBP, SPP1, TFF3, TGFA, TNF invasion of gonadal cell lines 0.00025 4 EDN1, PLAU*, PTP4A1, TNF invasion of nervous tissue cell lines 0.000341 6 CTSB*, IGF1R, MMP9, MYCN, PLAUR*, PTEN invasion of ovarian cancer cell lines 0.000587 3 EDN1, PLAU*, TNF invasion of brain cancer cell lines 0.00156 5 CTSB*, IGF1R, MMP9, PLAUR*, PTEN invasion of prostate cancer cell lines 0.00285 4 CTSB*, ETS2*, PLAUR*, PTEN survival 1.15E-4 - 1.06E-3 15 survival of leukemia cell lines 0.000115 6 IL1A, LYN, PML*, TNF, TNFRSF6, TXN* survival of tumor cell BCL2A1, DAF*, HGF, IL1A, LYN, NBS1*, PLAU*, PLAUR*, PML*, lines 0.00106 15 SOD2*, TCF3*, TNF, TNFRSF6, TXN*, UGCG* growth 1.18E-4 - 1.70E-3 42 CASP1*, CD44*, CD59*, CREBBP, HGF, HIF1A, IGFBP5, IGHG1*, growth of tumor 0.000118 16 MMP9, PLAU*, PTEN, STAT3, STAT5B*, TNF, TNFRSF6, TXN* growth of breast cancer BMX, HGF, IGF1R, IL1B*, OSM*, PFN1, PLAU*, PRKCD, PTEN, cell lines 0.000343 12 TGFA, TNF, TXN* growth of prostate BMX, CASP1*, CEACAM1*, CREM*, ETS2*, HGF, IGFBP5, PTEN, cancer cell lines 0.000902 10 STAT3, TGFA ADM, ANXA1, BMX, BTG2*, CASP1*, CEACAM1*, CREM*, EDN1, ETS2*, FES, GAP43, GGT1, HGF, IER3, IFNAR1, IGF1R, IGFBP5, growth of tumor cell 0.0017 34 IL1B*, OSM*, PFN1, PLAU*, PLAUR*, POR, PRKCD, PTEN, lines SOCS3*, SOD2*, SP1, STAT3, TAL1, TCF3*, TGFA, TNF, TXN* cancer 1.47E-4 - 1.47E-4 54

AIM2, ARID3A, BMX, CASP1*, CD44*, CD59*, CEACAM1*, COPEB, CR1*, CREBBP, ETS2*, G6PD, HGF, HIF1A, IER3, IFNGR1, IGFBP5, IGHG1*, IL1A, IL1B*, IL9R, JAK2*, LOH11CR2A, MMP9, 0.000147 54 MX1, MYB, MYCN, NFKBIA*, NRIP1, NTRK3, PIK3CG, PLAU*, PML*, PPP2R1B, PRKCD, PSEN1, PSMB9, PTCRA, PTEN, PTPRC, RALB*, S100A4, SLC5A5, SOD2*, STAT3, STAT5A, STAT5B*, TAL1, cancer TBX2, TCF3*, TGFA, TNF, TNFRSF6, TXN* binding 1.67E-4 - 1.67E-4 16 binding of tumor cell CD44*, CR1*, CXCL2*, FCAR*, FCGR2A*, HGF, IGF1R, IGFBP5, lines 0.000167 16 IL1B*, IL8RA, ITGAM*, OSM*, PLAU*, SELL, TNF, TNFRSF6 migration 2.28E-4 - 3.59E-3 17 migration of tumor cell 0.000228 17 CD44*, EDN1, GPR132, HGF, IGF1R, IL8*, ITGAM*, JAK2*, MMP9, lines OSM*, PLAU*, PLAUR*, PTEN, PTPNS1*, SDCBP, SPP1, TGFA migration of brain cancer cell lines 0.00106 6 HGF, MMP9, PLAU*, PLAUR*, PTEN, PTPNS1* migration of breast cancer cell lines 0.00359 7 IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, TGFA stimulation 2.50E-4 - 2.86E-3 4 stimulation of hepatoma cell lines 0.00025 4 HGF, IL1A, IL1B*, TNF stimulation of carcinoma cell lines 0.00286 2 IL1B*, TNF stimulation of lung cancer cell lines 0.00286 2 IL1B*, TNF cell viability 7.83E-4 - 2.85E-3 10 cell viability of tumor cell ADORA2A, BCL2A1, CASP1*, IL1B*, PRKCD, SOCS3*, SOD2*, lines 0.000783 10 TNF, TNFRSF6, UGCG* cell viability of cervical cancer cell lines 0.00285 4 BCL2A1, CASP1*, SOD2*, TNFRSF6 G0/G1 transition 1.15E-3 - 1.41E-3 5 arrest in G0/G1 transition of tumor cell 0.00115 5 lines HGF, IL1B*, PLAUR*, PTEN, TNF arrest in G0/G1 transition of brain 0.00141 3 cancer cell lines HGF, PLAUR*, PTEN development 1.28E-3 - 1.28E-3 13 CEACAM1*, HGF, HIF1A, IER3, MMP9, PML*, PTCRA, PTEN, development of tumor 0.00128 13 PTPRC, TBX2, TCF3*, TGFA, TNFRSF6 response 1.32E-3 - 1.32E-3 4

response of cancer cells 0.00132 4 IL8*, MYCN, PTEN, TNF proliferation 1.35E-3 - 1.35E-3 10 proliferation of leukemia CD44*, IGF1R, IL1A, IL1B*, LYN, MAPK14*, MYB, NFE2, PLAU*, cell lines 0.00135 10 TNF Hodgkin's disease 1.41E-3 - 1.41E-3 3 Hodgkin's disease 0.00141 3 NFKBIA*, STAT5A, TNFRSF6 activation 2.86E-3 - 3.06E-3 7 activation of brain cancer cell lines 0.00286 2 LY96, TNF activation of tumor cell lines 0.00306 7 ADM, IL8*, IL8RA, LY96, PRKR, THRA, TNF G1 phase 2.86E-3 - 2.86E-3 2 arrest in G1 phase of prostate cancer cell 0.00286 2 lines CREM*, PTEN hyperplasia 2.86E-3 - 2.86E-3 2 hyperplasia of synovial joint 0.00286 2 IL1B*, OSM* differentiation 3.07E-3 - 3.07E-3 19 BTG2*, CREBBP, FES, HGF, IGF1R, ITGAM*, MAPK14*, MYB, differentiation of tumor 0.00307 19 OSM*, PLAUR*, PML*, PRKCD, PSEN1, RGS6, SOCS3*, STAT3, cell lines TAL1, TCF3*, THRA size 3.94E-3 - 3.94E-3 4 size of tumor cell lines 0.00394 4 MAD*, MAPK14*, PTPRC, TNFRSF6 Cell-To-Cell Signaling and In 1.60E-8 - 3.94E-3 99 response 1.60E-8 - 2.49E-3 31 ADM, BMP2, CCL3, CCL4, CXCL2*, ERN1, FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FGR, GULP1, ICAM1, IFNAR1, 0.000000016 30 IL1B*, IL8*, ITGAM*, LYN, OSM*, PGLYRP, PRKCD, PTEN, response of cells PTPNS1*, SOCS3*, STAT5A, STAT5B*, TLR4*, TNF, TNFRSF6 CCL3, CCL4, CXCL2*, FCGR1A*, FCGR2A*, FCGR2B*, FGR, 0.000000401 18 ICAM1, IL8*, ITGAM*, LYN, PGLYRP, PTEN, PTPNS1*, STAT5A, response of blood cells STAT5B*, TNF, TNFRSF6 CCL3, CCL4, CXCL2*, FCGR2A*, FCGR2B*, IL8*, ITGAM*, response of phagocytes 0.0000096 10 PGLYRP, TNF, TNFRSF6 response of lymphatic CCL3, CCL4, CXCL2*, FCGR2A*, FCGR2B*, ICAM1, IL8*, ITGAM*, system cells 0.000151 13 PGLYRP, STAT5A, STAT5B*, TNF, TNFRSF6 response of antigen presenting cells 0.00017 6 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TNF, TNFRSF6 response of neutrophils 0.00025 7 CCL3, CCL4, CXCL2*, FCGR2A*, IL8*, ITGAM*, TNF response of macrophages 0.000828 5 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 response of cancer cells 0.00132 4 IL8*, MYCN, PTEN, TNF response of connective tissue cells 0.00135 6 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TLR4*, TNFRSF6 CCL3, CCL4, CXCL2*, FCGR2A*, ICAM1, IL8*, ITGAM*, STAT5A, response of leukocytes 0.00249 10 STAT5B*, TNF binding 1.63E-8 - 3.78E-3 45 BPI, CCL20, CCL3, CCL4, CCR1*, CD24*, CD44*, CR1*, F5*, 1.63E-08 26 FCAR*, FCGR2A*, FGR, FPR1, FYB*, HGF, ICAM1, IL1A, IL8*, binding of blood cells ITGAM*, LYN, NFE2, PTPRC, SELL, SIGLEC5, TNF, TNFRSF6 BPI, CCL20, CCL3, CCL4, CCR1*, CD24*, CD44*, CEACAM1*, CR1*, CXCL2*, F5*, FCAR*, FCGR1A*, FCGR2A*, FGR, FPR1, FYB*, HGF, ICAM1, IGF1R, IGFBP5, IL13RA1*, IL18R1, IL18RAP, 1.64E-08 45 IL1A, IL1B*, IL1R1, IL4R, IL8*, IL8RA, ITGAM*, LY96, LYN, NFE2, OSM*, PLAU*, PLAUR*, PTPRC, SELL, SIGLEC5, SPP1, TGFA, binding of cells TLR4*, TNF, TNFRSF6 BPI, CCL3, CCR1*, FCAR*, FCGR2A*, FGR, FPR1, ICAM1, IL1A, binding of phagocytes 6.44E-08 15 IL8*, ITGAM*, LYN, PTPRC, SELL, TNF BPI, CCL20, CCL3, CCL4, CCR1*, CD44*, FCAR*, FCGR2A*, FGR, 0.00000012 20 FPR1, FYB*, HGF, ICAM1, IL1A, IL8*, ITGAM*, LYN, SELL, TNF, binding of leukocytes TNFRSF6 BPI, CCL20, CCL3, CCL4, CCR1*, CD44*, FCAR*, FCGR2A*, FGR, binding of lymphatic 0.00000056 20 FPR1, HGF, ICAM1, IL1A, IL8*, ITGAM*, LYN, PTPRC, SELL, TNF, system cells TNFRSF6 binding of macrophages 0.0000039 10 BPI, CCL3, CCR1*, FPR1, IL1A, IL8*, ITGAM*, PTPRC, SELL, TNF binding of monocytes 0.00000453 8 BPI, CCL3, CCR1*, IL1A, IL8*, ITGAM*, SELL, TNF binding of mononuclear BPI, CCL20, CCL3, CCL4, CCR1*, CD44*, FYB*, HGF, ICAM1, IL1A, leukocytes 0.00000557 15 IL8*, ITGAM*, SELL, TNF, TNFRSF6 binding of neutrophils 0.0000307 8 FCAR*, FCGR2A*, FGR, ICAM1, IL8*, ITGAM*, LYN, TNF binding of connective BPI, CCL3, CCR1*, FPR1, ICAM1, IL1A, IL8*, ITGAM*, PLAUR*, tissue cells 0.0000375 12 PTPRC, SELL, TNF binding of tumor cell CD44*, CR1*, CXCL2*, FCAR*, FCGR2A*, HGF, IGF1R, IGFBP5, lines 0.000167 16 IL1B*, IL8RA, ITGAM*, OSM*, PLAU*, SELL, TNF, TNFRSF6 binding of leukocyte cell CD44*, CR1*, CXCL2*, FYB*, IL13RA1*, IL8RA, ITGAM*, PLAU*, lines 0.00161 11 SELL, TNF, TNFRSF6 binding of red blood cells 0.00198 4 CR1*, FCGR2A*, ITGAM*, SIGLEC5 binding of lymphocytes 0.00303 9 CCL20, CCL4, CCR1*, CD44*, HGF, ICAM1, SELL, TNF, TNFRSF6 binding of kidney cell lines 0.00378 6 FCGR2A*, IL13RA1*, IL18R1, ITGAM*, PLAUR*, SIGLEC5 phagocytosis 1.78E-6 - 3.94E-3 15 FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FGR, GULP1, 0.00000178 15 ITGAM*, LYN, PGLYRP, PRKCD, PTEN, PTPNS1*, TLR4*, phagocytosis of cells TNFRSF6 phagocytosis of red blood cells 0.00000534 7 FCGR1A*, FCGR2A*, FGR, ITGAM*, LYN, PTEN, PTPNS1* phagocytosis of blood FCGR1A*, FCGR2A*, FCGR2B*, FGR, ITGAM*, LYN, PGLYRP, cells 0.0000165 10 PTEN, PTPNS1*, TNFRSF6 phagocytosis of connective tissue cells 0.00156 5 FCGR2A*, FCGR2B*, PGLYRP, TLR4*, TNFRSF6 phagocytosis of macrophages 0.00198 4 FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 phagocytosis of leukocyte cell lines 0.00394 4 FCGR2A*, FCGR2B*, FGR, PRKCD chemokinesis 2.48E-6 - 2.48E-6 5 chemokinesis of neutrophils 0.00000248 5 CCL3, CCL4, CXCL2*, IL8*, TNF activation 7.46E-6 - 3.52E-3 63 BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR*, FCER1G, FCGR2A*, FCGR2B*, FYB*, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, 0.00000746 58 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, activation of blood cells TNFSF13B*, TXN* BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR*, FCGR2B*, FYB*, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, PDCD1LG1*, 0.0000114 56 PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, activation of leukocytes TNFSF13B*, TXN* ADM, BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2*, FCAR*, FCER1G, FCGR2A*, FCGR2B*, FYB*, GGT1, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL8RA, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, 0.0000128 63 MAPK14*, MMP9, NFKB2*, NPY2R, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, THRA, TLR4*, TNF, TNFRSF6, TNFSF13B*, activation of cells TXN* CCL3, CCL4, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL8*, IL9R, INDO, JAK3*, MAPK14*, MMP9, PDCD1LG1*, PIK3CG, PRKR, 0.0000199 40 PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, activation of T SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TLR4*, TNF, lymphocytes TNFRSF6, TXN* CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR , FCGR2B*, FYB*, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, 0.0000331 54 MAPK14*, MMP9, NFKB2*, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, activation of lymphatic PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, system cells TAL1, TCF3*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CCL3, CCL4, CD44 , CEACAM1 , CR1 , ETS2 , FCGR2B , FYB , ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, 0.0000472 49 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SERPINB1*, SPP1, activation of STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, lymphocytes TNFSF13B*, TXN* CCL3, CCL4, EDN1, FCAR*, ICAM1, IL1A, IL1B*, IL1RN*, IL8*, activation of phagocytes 0.0000757 15 ITGAM*, LY96, PTGER3, SELL, TLR4*, TNF activation of connective CCL3, CCL4, EDN1, FCGR2B*, GGT1, ICAM1, IGHG1*, IL1A, IL1B*, tissue cells 0.000149 16 IL1RN*, IL8*, LY96, NPY2R, PTGER3, TLR4*, TNF activation of neutrophils 0.00075 8 FCAR*, IL1A, IL1B*, IL1RN*, IL8*, ITGAM*, SELL, TNF activation of osteocytes 0.00169 6 GGT1, IGHG1*, IL1A, IL1RN*, NPY2R, TNF activation of CCL3, CCL4, EDN1, ICAM1, IL1B*, IL8*, LY96, PTGER3, TLR4*, macrophages 0.00221 10 TNF activation of brain cancer cell lines 0.00286 2 LY96, TNF activation of nervous tissue cell lines 0.00286 2 LY96, TNF activation of tumor cell lines 0.00306 7 ADM, IL8*, IL8RA, LY96, PRKR, THRA, TNF CD44*, FCGR2B*, IFNAR1, IL4R, LY96, LYN, PIK3AP1, PRKCD, activation of B 0.00309 18 PTEN, PTPN2, PTPNS1*, PTPRC, STAT5A, TCF3*, TLR4*, TNF, lymphocytes TNFSF13B*, TXN* activation of antigen CCL3, CCL4, EDN1, ICAM1, IFNAR1, IL1B*, IL8*, LY96, PTGER3, presenting cells 0.00352 12 TLR4*, TNF, TNFRSF6 recruitment 1.12E-5 - 2.86E-3 15 recruitment of blood CCL3, CCL4, CCR1*, CD44*, CXCL2*, ENTPD1*, ICAM1, IGHG1*, cells 0.0000112 14 IL8*, PIK3CG, SELL, TLR4*, TNF, TXN* recruitment of CCL3, CCL4, CCR1*, CD44*, CXCL2*, ICAM1, IL8*, PIK3CG, TLR4*, phagocytes 0.0000439 10 TNF CCL3, CCL4, CCR1*, CD44*, CXCL2*, ENTPD1*, ICAM1, IGHG1*, recruitment of cells 0.0000757 15 IL8*, LYN, PIK3CG, SELL, TLR4*, TNF, TXN* recruitment of CCL3, CCL4, CCR1*, CXCL2*, ICAM1, IGHG1*, IL8*, PIK3CG, SELL, leukocytes 0.000076 12 TLR4*, TNF, TXN* recruitment of neutrophils 0.000101 8 CCL3, CCL4, CCR1*, CXCL2*, IL8*, PIK3CG, TLR4*, TNF recruitment of granulocytes 0.000306 9 CCL3, CCL4, CCR1*, CXCL2*, IGHG1*, IL8*, PIK3CG, TLR4*, TNF recruitment of lymphatic CCL3, CCL4, CCR1*, CD44*, CXCL2*, ICAM1, IGHG1*, IL8*, system cells 0.000391 11 PIK3CG, TLR4*, TNF recruitment of lymphocytes 0.00258 6 CCL3, CCR1*, CXCL2*, ICAM1, IL8*, TNF recruitment of natural killer T lymphocytes 0.00286 2 CXCL2*, TNF priming 1.12E-4 - 1.12E-4 4 priming of neutrophils 0.000112 4 IL1A, IL1B*, IL8*, TNF attachment 1.13E-4 - 2.85E-3 13 CD44*, CSPG2*, ICAM1, IGF1R, IL1B*, ITGAM*, PLAU*, PLAUR*, attachment of cells 0.000113 13 PRKCD, SELL, SPP1, TGFA, TNF attachment of leukocytes 0.00285 4 ICAM1, IL1B*, ITGAM*, SELL induction 1.53E-4 - 2.86E-3 18 induction of chondrocytes 0.000153 3 BMP2, IL1B*, TNF induction of connective tissue cells 0.00103 7 BMP2, EDN1, IL1B*, NTRK3, OSM*, TNF, TXN* ADM, BMP2, CEACAM1*, EDN1, HGF, IGFBP5, IGHG1*, IL1B*, IL8*, induction of cells 0.00236 18 JAK2*, MYB, NTRK3, OSM*, REN, SPP1, TGFA, TNF, TXN* induction of osteocytes 0.00286 2 EDN1, TNF detachment 2.07E-4 - 2.86E-3 9 detachment of cells 0.000207 9 ANXA1, BPI, GSN, IGF1R, PTPNS1*, PTPRC, SELL, TFF3, TNF detachment of phagocytes 0.000587 3 ANXA1, PTPNS1*, PTPRC detachment of blood cells 0.00132 4 ANXA1, PTPNS1*, PTPRC, SELL detachment of macrophages 0.00286 2 PTPNS1*, PTPRC stimulation 2.50E-4 - 3.94E-3 25 stimulation of liver cells 0.00025 5 HGF, IL1B*, REN, TGFA, TNF stimulation of hepatoma cell lines 0.00025 4 HGF, IL1A, IL1B*, TNF stimulation of liver cell lines 0.00025 4 HGF, IL1A, IL1B*, TNF stimulation of synovial cells 0.00025 4 IL1A, IL1B*, OSM*, TNF stimulation of osteocytes 0.000479 4 EDN1, IL1A, PLAU*, TNF stimulation of hepatocytes 0.000825 4 HGF, IL1B*, TGFA, TNF stimulation of kidney cells 0.000825 4 EDN1, HGF, IL1B*, TNF stimulation of BMP2, CAMP, EDN1, IL1A, IL1B*, NTRK3, OSM*, PLAU*, TNF, connective tissue cells 0.00104 10 TXN* ADM, BMP2, CAMP, CEACAM1*, CXCL2*, EDN1, HGF, IGFBP5, IGHG1*, IL1A, IL1B*, IL8*, JAK2*, MYB, NTRK3, OSM*, 0.00124 25 PDCD1LG1*, PLAU*, PRKCG, REN, SPP1, TGFA, TLR4*, TNF, stimulation of cells TXN* stimulation of carcinoma cell lines 0.00286 2 IL1B*, TNF stimulation of lung cancer cell lines 0.00286 2 IL1B*, TNF stimulation of lung cell lines 0.00286 2 IL1B*, TNF stimulation of osteoblasts 0.00286 2 EDN1, PLAU* stimulation of muscle cells 0.00394 4 EDN1, IL1B*, IL8*, TNF suppression 2.86E-3 - 2.86E-3 2 suppression of hematopoietic 0.00286 2 progenitor cells CCL3, CCL4 Hematological System Devel1.63E-8 - 2.86E-3 105 binding 1.63E-8 - 1.98E-3 26 BPI, CCL20, CCL3, CCL4, CCR1*, CD24*, CD44*, CR1*, F5*, 1.63E-08 26 FCAR*, FCGR2A*, FGR, FPR1, FYB*, HGF, ICAM1, IL1A, IL8*, binding of blood cells ITGAM*, LYN, NFE2, PTPRC, SELL, SIGLEC5, TNF, TNFRSF6 BPI, CCL3, CCR1*, FCAR*, FCGR2A*, FGR, FPR1, ICAM1, IL1A, binding of phagocytes 6.44E-08 15 IL8*, ITGAM*, LYN, PTPRC, SELL, TNF BPI, CCL20, CCL3, CCL4, CCR1*, CD44*, FCAR*, FCGR2A*, FGR, 0.00000012 20 FPR1, FYB*, HGF, ICAM1, IL1A, IL8*, ITGAM*, LYN, SELL, TNF, binding of leukocytes TNFRSF6

binding of macrophages 0.0000039 10 BPI, CCL3, CCR1*, FPR1, IL1A, IL8*, ITGAM*, PTPRC, SELL, TNF binding of neutrophils 0.0000307 8 FCAR*, FCGR2A*, FGR, ICAM1, IL8*, ITGAM*, LYN, TNF binding of red blood cells 0.00198 4 CR1*, FCGR2A*, ITGAM*, SIGLEC5 infiltration 3.03E-8 - 3.26E-4 23 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, FCAR*, 3.03E-08 23 FCER1G, FCGR2B*, ICAM1, IL4R, IL8*, JAK3*, MAPK14*, OSM*, infiltration of blood cells PIK3CG, PLAU*, REN, SELL, STAT3, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CXCL2*, FCAR*, FCER1G, 9.76E-08 16 ICAM1, IL8*, MAPK14*, PIK3CG, PLAU*, REN, SELL, TNF, infiltration of phagocytes TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CXCL2*, FCER1G, ICAM1, IL8*, infiltration of neutrophils 0.000000111 13 MAPK14*, PIK3CG, SELL, TNF, TNFRSF6 ALOX5AP, CASP1*, CCL3, CCL4, CCR1*, CD44*, CXCL2*, 0.000000405 20 FCER1G, FCGR2B*, ICAM1, IL4R, IL8*, MAPK14*, OSM*, PIK3CG, infiltration of leukocytes REN, SELL, STAT3, TNF, TNFRSF6 infiltration of macrophages 0.000326 7 CCL3, CCL4, FCAR*, ICAM1, PLAU*, REN, SELL accumulation 3.32E-7 - 6.87E-7 19 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of 0.000000332 18 IER3, IL1R1, IL8*, ITGAM*, MMP9, PML*, PTX3, SELL, TNF, leukocytes TNFRSF6 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of blood 0.000000687 19 IER3, IL1R1, IL1RN*, IL8*, ITGAM*, MMP9, PML*, PTX3, SELL, TNF, cells TNFRSF6 response 4.01E-7 - 2.49E-3 18 CCL3, CCL4, CXCL2*, FCGR1A*, FCGR2A*, FCGR2B*, FGR, 0.000000401 18 ICAM1, IL8*, ITGAM*, LYN, PGLYRP, PTEN, PTPNS1*, STAT5A, response of blood cells STAT5B*, TNF, TNFRSF6 CCL3, CCL4, CXCL2*, FCGR2A*, FCGR2B*, IL8*, ITGAM*, response of phagocytes 0.0000096 10 PGLYRP, TNF, TNFRSF6 response of neutrophils 0.00025 7 CCL3, CCL4, CXCL2*, FCGR2A*, IL8*, ITGAM*, TNF response of macrophages 0.000828 5 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 CCL3, CCL4, CXCL2*, FCGR2A*, ICAM1, IL8*, ITGAM*, STAT5A, response of leukocytes 0.00249 10 STAT5B*, TNF engulfment 9.16E-7 - 9.16E-7 12 engulfment of blood FCGR1A*, FCGR2A*, FCGR2B*, FGR, IL1A, ITGAM*, LYN, cells 0.000000916 12 PGLYRP, PTEN, PTPNS1*, TNF, TNFRSF6 chemokinesis 2.48E-6 - 2.48E-6 5 chemokinesis of neutrophils 0.00000248 5 CCL3, CCL4, CXCL2*, IL8*, TNF degranulation 3.99E-6 - 1.84E-3 7 degranulation of neutrophils 0.00000399 6 CCL3, CCL4, CXCL2*, IL8*, PLAUR*, TNF degranulation of leukocytes 0.00184 7 CCL3, CCL4, CXCL2*, IL8*, LYN, PLAUR*, TNF shape change 3.99E-6 - 4.08E-5 9 shape change of neutrophils 0.00000399 6 FCAR*, FGR, ITGAM*, LYN, SELL, TNF shape change of leukocytes 0.0000408 9 CCL3, CD44*, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF adhesion 4.76E-6 - 4.65E-4 23 ANXA1, CCL20, CCL4, CD44*, CD59*, CR1*, DAF*, FYB*, HGF, 0.00000476 23 ICAM1, IFNGR1, IL1A, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, adhesion of blood cells PTPNS1*, SELL, SERPING1, SPP1, TNF, TXN* ANXA1, ICAM1, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, SELL, TNF, adhesion of neutrophils 0.0000072 10 TXN* ANXA1, ICAM1, IL1A, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, adhesion of phagocytes 0.0000311 12 PTPNS1*, SELL, TNF, TXN* ANXA1, CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, IL1A, IL1B*, adhesion of leukocytes 0.000228 17 IL8*, ITGAM*, PLAU*, PLAUR*, SELL, SPP1, TNF, TXN* adhesion of red blood cells 0.000465 6 CD59*, CR1*, DAF*, PTPNS1*, SERPING1, TNF phagocytosis 5.34E-6 - 1.98E-3 10 phagocytosis of red blood cells 0.00000534 7 FCGR1A*, FCGR2A*, FGR, ITGAM*, LYN, PTEN, PTPNS1* phagocytosis of blood FCGR1A*, FCGR2A*, FCGR2B*, FGR, ITGAM*, LYN, PGLYRP, cells 0.0000165 10 PTEN, PTPNS1*, TNFRSF6 phagocytosis of macrophages 0.00198 4 FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 activation 7.46E-6 - 2.21E-3 58 BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR*, FCER1G, FCGR2A*, FCGR2B*, FYB*, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, 0.00000746 58 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, activation of blood cells TNFSF13B*, TXN* BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR*, FCGR2B*, FYB*, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, PDCD1LG1*, 0.0000114 56 PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, activation of leukocytes TNFSF13B*, TXN* CCL3, CCL4, EDN1, FCAR*, ICAM1, IL1A, IL1B*, IL1RN*, IL8*, activation of phagocytes 0.0000757 15 ITGAM*, LY96, PTGER3, SELL, TLR4*, TNF activation of neutrophils 0.00075 8 FCAR*, IL1A, IL1B*, IL1RN*, IL8*, ITGAM*, SELL, TNF activation of CCL3, CCL4, EDN1, ICAM1, IL1B*, IL8*, LY96, PTGER3, TLR4*, macrophages 0.00221 10 TNF proliferation 1.01E-5 - 5.21E-5 43 CCL20, CCL3, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL8*, IL9R, INDO, JAK2*, JAK3*, LY96, LYN, MMP9, PDCD1LG1*, PIK3AP1, PIK3CG, 0.0000101 43 PRKCD, PRKR, PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, PTPRO, proliferation of blood RIPK2, SOCS3*, SPP1, STAT5A, STAT5B*, TLR4*, TNF, TNFRSF6, cells TNFSF13B*, TXN* CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000521 38 MMP9, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, proliferation of PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, leukocytes STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* recruitment 1.12E-5 - 1.01E-4 14 recruitment of blood CCL3, CCL4, CCR1*, CD44*, CXCL2*, ENTPD1*, ICAM1, IGHG1*, cells 0.0000112 14 IL8*, PIK3CG, SELL, TLR4*, TNF, TXN* recruitment of CCL3, CCL4, CCR1*, CD44*, CXCL2*, ICAM1, IL8*, PIK3CG, TLR4*, phagocytes 0.0000439 10 TNF recruitment of CCL3, CCL4, CCR1*, CXCL2*, ICAM1, IGHG1*, IL8*, PIK3CG, SELL, leukocytes 0.000076 12 TLR4*, TNF, TXN* recruitment of neutrophils 0.000101 8 CCL3, CCL4, CCR1*, CXCL2*, IL8*, PIK3CG, TLR4*, TNF differentiation 1.76E-5 - 1.76E-5 21 BMP2, CCR1*, ETS2*, IFI16*, IGF1R, IRF7, JAK2*, JAK3*, LYN, myeloid blood cell 0.0000176 21 MYB, MYOD1, PLSCR1*, PML*, PTPRC, SFXN1, SOCS3*, SPP1, differentiation STAT5A, STAT5B*, TAL1, TNF respiratory burst 2.29E-5 - 2.29E-5 7 respiratory burst of neutrophils 0.0000229 7 CXCL2*, FCAR*, FGR, ITGAM*, LYN, PIK3CG, TNF chemotaxis 2.96E-5 - 1.23E-3 22 CAMP, CCL20, CCL3, CCL4, CCR1*, CXCL16, CXCL2*, FCER1G, chemotaxis of 0.0000296 22 FPR1, FPRL1*, IL1B*, IL8*, IL8RA, ITGAM*, LYN, MMP9, PIK3CG, leukocytes PLAU*, PLAUR*, SPP1, TNF, TXN* chemotaxis of CAMP, CCL3, CCL4, CXCL2*, FCER1G, FPR1, IL1B*, IL8*, IL8RA, neutrophils 0.000168 12 ITGAM*, PIK3CG, TNF chemotaxis of CAMP, CCL3, CCL4, CXCL2*, FCER1G, FPR1, FPRL1*, IL1B*, IL8*, phagocytes 0.00123 14 IL8RA, ITGAM*, PIK3CG, PLAUR*, TNF myelopoiesis 5.28E-5 - 5.28E-5 9 CCL3, CCL4, CXCL2*, JAK2*, PML*, PTPN2, SOCS3*, STAT5A, myelopoiesis 0.0000528 9 STAT5B* priming 1.12E-4 - 1.12E-4 4 priming of neutrophils 0.000112 4 IL1A, IL1B*, IL8*, TNF hematopoiesis 1.45E-4 - 2.85E-3 35 BMP2, CCL3, CCL4, CCR1*, CXCL2*, ETS2*, FCGR2B*, HHEX, IFI16*, IFNGR2, IGF1R, IGHG1*, IRF7, JAK2*, JAK3*, LYN, 0.000145 35 MAPK14*, MYB, MYOD1, NFYA, PIK3CG, PLSCR1*, PML*, PTPN2, PTPRC, RIPK2, SFXN1, SOCS3*, SPP1, STAT5A, STAT5B*, TAL1, hematopoiesis TCF3*, TNF, TNFSF13B* hematopoiesis of leukocytes 0.00285 4 JAK3*, NFYA, PTPN2, TCF3* erythropoiesis 2.50E-4 - 2.50E-4 4 erythropoiesis of mice 0.00025 4 JAK2*, SOCS3*, STAT5A, STAT5B* transmigration 5.35E-4 - 2.68E-3 7 transmigration of leukocytes 0.000535 7 CCL3, CCL4, FPR1, IL1B*, IL8*, PTPNS1*, TNF transmigration of phagocytes 0.00268 5 CCL3, FPR1, IL8*, PTPNS1*, TNF influx 5.77E-4 - 5.77E-4 5 influx of leukocytes 0.000577 5 CCL3, CCL4, CXCL2*, MMP9, TNF detachment 5.87E-4 - 2.86E-3 4 detachment of phagocytes 0.000587 3 ANXA1, PTPNS1*, PTPRC detachment of blood cells 0.00132 4 ANXA1, PTPNS1*, PTPRC, SELL detachment of macrophages 0.00286 2 PTPNS1*, PTPRC attachment 2.85E-3 - 2.85E-3 4 attachment of leukocytes 0.00285 4 ICAM1, IL1B*, ITGAM*, SELL presence 2.85E-3 - 2.85E-3 4 presence of blood cells 0.00285 4 FCGR2A*, FGR, IFNAR1, JAK3* oxidation 2.86E-3 - 2.86E-3 2 oxidation of neutrophils 0.00286 2 CCL3, CCL4 Cellular Function and Mainte 3.31E-8 - 3.94E-3 26 engulfment 3.31E-8 - 2.86E-3 19 BMX, FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FGR, 3.31E-08 19 GULP1, HIP1*, IL1A, ITGAM*, LYN, PGLYRP, PRKCD, PTEN, engulfment of cells PTPNS1*, TLR4*, TNF, TNFRSF6 engulfment of blood FCGR1A*, FCGR2A*, FCGR2B*, FGR, IL1A, ITGAM*, LYN, cells 0.000000916 12 PGLYRP, PTEN, PTPNS1*, TNF, TNFRSF6 engulfment of lymphatic system cells 0.000838 7 FCGR2A*, FCGR2B*, IL1A, ITGAM*, PGLYRP, TNF, TNFRSF6 engulfment of eosinophils 0.00286 2 IL1A, TNF phagocytosis 1.78E-6 - 3.94E-3 15 FCAR*, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FGR, GULP1, 0.00000178 15 ITGAM*, LYN, PGLYRP, PRKCD, PTEN, PTPNS1*, TLR4*, phagocytosis of cells TNFRSF6 phagocytosis of red blood cells 0.00000534 7 FCGR1A*, FCGR2A*, FGR, ITGAM*, LYN, PTEN, PTPNS1* phagocytosis of blood FCGR1A*, FCGR2A*, FCGR2B*, FGR, ITGAM*, LYN, PGLYRP, cells 0.0000165 10 PTEN, PTPNS1*, TNFRSF6 phagocytosis of connective tissue cells 0.00156 5 FCGR2A*, FCGR2B*, PGLYRP, TLR4*, TNFRSF6 phagocytosis of macrophages 0.00198 4 FCGR2A*, FCGR2B*, PGLYRP, TNFRSF6 phagocytosis of leukocyte cell lines 0.00394 4 FCGR2A*, FCGR2B*, FGR, PRKCD respiratory burst 2.29E-5 - 2.29E-5 7 respiratory burst of neutrophils 0.0000229 7 CXCL2*, FCAR*, FGR, ITGAM*, LYN, PIK3CG, TNF organization 1.98E-3 - 1.98E-3 4 organization of blood cells 0.00198 4 FCGR2A*, IFNGR1, TLR4*, TNF presence 2.85E-3 - 2.85E-3 4 presence of blood cells 0.00285 4 FCGR2A*, FGR, IFNAR1, JAK3* oxidation 2.86E-3 - 2.86E-3 2 oxidation of neutrophils 0.00286 2 CCL3, CCL4 Organismal Functions 3.30E-7 - 3.30E-7 7 fever 3.30E-7 - 3.30E-7 7 fever 0.00000033 7 CCL3, CCL4, IL1A, IL1B*, IL1RN*, PTGER3, TNF Immune and Lymphatic Syst 3.32E-7 - 3.52E-3 90 accumulation 3.32E-7 - 6.73E-4 19 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of 0.000000332 18 IER3, IL1R1, IL8*, ITGAM*, MMP9, PML*, PTX3, SELL, TNF, leukocytes TNFRSF6 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of 0.00000116 18 IER3, IL1R1, IL1RN*, IL8*, MMP9, PML*, PTX3, SELL, TNF, lymphatic system cells TNFRSF6

accumulation of 0.000336 8 mononuclear leukocytes BCL3*, CCL3, CFLAR*, ETS2*, ICAM1, IER3, SELL, TNFRSF6 accumulation of lymphocytes 0.000673 7 BCL3*, CCL3, CFLAR*, ICAM1, IER3, SELL, TNFRSF6 degranulation 3.99E-6 - 1.84E-3 10 degranulation of neutrophils 0.00000399 6 CCL3, CCL4, CXCL2*, IL8*, PLAUR*, TNF CCL3, CCL4, CXCL2*, FCER1G, FCGR2B*, FPR1, IL8*, LYN, degranulation of cells 0.000309 10 PLAUR*, TNF degranulation of leukocytes 0.00184 7 CCL3, CCL4, CXCL2*, IL8*, LYN, PLAUR*, TNF shape change 3.99E-6 - 8.62E-5 9 shape change of neutrophils 0.00000399 6 FCAR*, FGR, ITGAM*, LYN, SELL, TNF shape change of granulocytes 0.0000153 8 CCL3, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF shape change of leukocytes 0.0000408 9 CCL3, CD44*, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF shape change of lymphatic system cells 0.0000862 9 CCL3, CD44*, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF adhesion 6.40E-6 - 2.86E-3 23 adhesion of leukocyte ANXA1, CCL3, CCL4, CD44*, CD59*, DAF*, FES, ICAM1, IL8*, cell lines 0.0000064 14 ITGAM*, PLAU*, PTPNS1*, SELL, TNF ANXA1, CCL20, CCL4, CD44*, FYB*, HGF, ICAM1, IFNGR1, IL1A, adhesion of lymphatic 0.00000654 19 IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, PTPNS1*, SELL, SPP1, TNF, system cells TXN* ANXA1, ICAM1, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, SELL, TNF, adhesion of neutrophils 0.0000072 10 TXN* adhesion of bone ANXA1, CD44*, ICAM1, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, SELL, marrow cells 0.0000624 11 TNF, TXN* ANXA1, CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, IL1A, IL1B*, adhesion of leukocytes 0.000228 17 IL8*, ITGAM*, PLAU*, PLAUR*, SELL, SPP1, TNF, TXN* adhesion of 0.000392 12 CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, IL1A, IL8*, PLAU*, mononuclear leukocytes SELL, SPP1, TNF adhesion of CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, PLAU*, SELL, SPP1, lymphocytes 0.000783 10 TNF adhesion of T lymphocytes 0.000866 9 CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, PLAU*, SELL, SPP1 adhesion of memory T lymphocytes 0.00286 2 CCL20, HGF activation 1.14E-5 - 3.52E-3 56 BCL2A1, CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR*, FCGR2B*, FYB*, HGF, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, PDCD1LG1*, 0.0000114 56 PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, activation of leukocytes TNFSF13B*, TXN* CCL3, CCL4, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL8*, IL9R, INDO, JAK3*, MAPK14*, MMP9, PDCD1LG1*, PIK3CG, PRKR, 0.0000199 40 PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, activation of T SERPINB1*, SPP1, STAT5A, STAT5B*, TAL1, TLR4*, TNF, lymphocytes TNFRSF6, TXN* CCL3, CCL4, CD44 , CEACAM1 , CR1 , EDN1, ETS2 , FCAR , FCGR2B*, FYB*, ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL1RN*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, 0.0000331 54 MAPK14*, MMP9, NFKB2*, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTGER3, PTPN2, PTPNS1*, PTPRC, activation of lymphatic PTPRJ, REN, RIPK2, SELL, SERPINB1*, SPP1, STAT5A, STAT5B*, system cells TAL1, TCF3*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CCL3, CCL4, CD44 , CEACAM1 , CR1 , ETS2 , FCGR2B , FYB , ICAM1, IFNAR1, IFNGR2, IGF1R, IGHG1*, IL1A, IL1B*, IL4R, IL8*, IL9R, INDO, ITGAM*, JAK3*, LY96, LYN, MAPK14*, MMP9, NFKB2*, 0.0000472 49 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, REN, RIPK2, SERPINB1*, SPP1, activation of STAT5A, STAT5B*, TAL1, TCF3*, TLR4*, TNF, TNFRSF6, lymphocytes TNFSF13B*, TXN* activation of neutrophils 0.00075 8 FCAR*, IL1A, IL1B*, IL1RN*, IL8*, ITGAM*, SELL, TNF activation of CCL3, CCL4, EDN1, ICAM1, IL1B*, IL8*, LY96, PTGER3, TLR4*, macrophages 0.00221 10 TNF CD44*, FCGR2B*, IFNAR1, IL4R, LY96, LYN, PIK3AP1, PRKCD, activation of B 0.00309 18 PTEN, PTPN2, PTPNS1*, PTPRC, STAT5A, TCF3*, TLR4*, TNF, lymphocytes TNFSF13B*, TXN* activation of antigen CCL3, CCL4, EDN1, ICAM1, IFNAR1, IL1B*, IL8*, LY96, PTGER3, presenting cells 0.00352 12 TLR4*, TNF, TNFRSF6 proliferation 3.89E-5 - 4.33E-4 50

CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000389 40 MMP9, NFE2, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, proliferation of PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT3, lymphatic system cells STAT5A, STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, MMP9, 0.0000443 37 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTPN2, proliferation of PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, STAT5B*, lymphocytes TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000521 38 MMP9, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, proliferation of PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, leukocytes STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CD44*, CEACAM1*, CR1*, ETS2*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL9R, INDO, JAK3*, MMP9, PDCD1LG1*, PIK3CG, proliferation of T 0.0000923 29 PRKR, PTEN, PTPN2, PTPNS1*, PTPRJ, RIPK2, SPP1, STAT5A, lymphocytes STAT5B*, TLR4*, TNF, TNFRSF6, TXN* proliferation of B CD44*, FCGR2B*, IFNAR1, IL4R, LY96, LYN, PIK3AP1, PRKCD, lymphocytes 0.000388 16 PTEN, PTPN2, PTPRC, STAT5A, TLR4*, TNF, TNFSF13B*, TXN* CD44*, HGF, IGF1R, IL13RA1*, IL1A, IL1B*, IL8*, IL9R, JAK2*, proliferation of 0.000433 22 JAK3*, LDHA, LYN, MAPK14*, MYB, NFE2, OSM*, PLAU*, SPP1, leukocyte cell lines STAT3, STAT5A, STAT5B*, TNF cell spreading 4.54E-5 - 3.41E-4 6 cell spreading of neutrophils 0.0000454 5 FCAR*, FGR, ITGAM*, LYN, TNF cell spreading of leukocytes 0.000244 6 CD44*, FCAR*, FGR, ITGAM*, LYN, TNF cell spreading of lymphatic system cells 0.000341 6 CD44*, FCAR*, FGR, ITGAM*, LYN, TNF development 6.11E-5 - 2.50E-3 22 BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of 0.0000611 21 JAK3*, LYN, NFKB2*, NFYA, OSM*, PTPN2, PTPRC, STAT5A, leukocytes TAL1, TAPBP, TCF3*, TNFSF13B* BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of 0.000114 20 JAK3*, LYN, NFKB2*, OSM*, PTPN2, PTPRC, STAT5A, TAL1, lymphocytes TAPBP, TCF3*, TNFSF13B* BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of 0.000183 22 JAK3*, LYN, NFKB2*, NFYA, OSM*, PTPN2, PTPRC, STAT5A, lymphatic system cells TAL1, TAPBP, TCF3*, TNF, TNFSF13B* development of T EFNA1, EGR3, FCER1G, IFNGR2, IL1A, IL4R, JAK3*, OSM*, lymphocytes 0.0025 13 PTPRC, STAT5A, TAL1, TAPBP, TCF3* hematopoiesis 2.85E-3 - 2.85E-3 4 hematopoiesis of leukocytes 0.00285 4 JAK3*, NFYA, PTPN2, TCF3* detachment 2.86E-3 - 2.86E-3 2 detachment of macrophages 0.00286 2 PTPNS1*, PTPRC Tissue Development 3.32E-7 - 3.55E-3 66 accumulation 3.32E-7 - 6.73E-4 23 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of 0.000000332 18 IER3, IL1R1, IL8*, ITGAM*, MMP9, PML*, PTX3, SELL, TNF, leukocytes TNFRSF6 ALOX5*, BCL3*, CCL3, CCR1*, CD24*, CFLAR*, CR1*, ETS2*, HGF, 0.000000562 23 ICAM1, IER3, IFI16*, IL1R1, IL1RN*, IL8*, ITGAM*, MMP9, OSM*, accumulation of cells PML*, PTX3, SELL, TNF, TNFRSF6 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of blood 0.000000687 19 IER3, IL1R1, IL1RN*, IL8*, ITGAM*, MMP9, PML*, PTX3, SELL, TNF, cells TNFRSF6 ALOX5*, BCL3*, CCL3, CCR1*, CFLAR*, CR1*, ETS2*, ICAM1, accumulation of 0.00000116 18 IER3, IL1R1, IL1RN*, IL8*, MMP9, PML*, PTX3, SELL, TNF, lymphatic system cells TNFRSF6 accumulation of 0.000336 8 mononuclear leukocytes BCL3*, CCL3, CFLAR*, ETS2*, ICAM1, IER3, SELL, TNFRSF6 accumulation of lymphocytes 0.000673 7 BCL3*, CCL3, CFLAR*, ICAM1, IER3, SELL, TNFRSF6 adhesion 4.76E-6 - 2.86E-3 27 ANXA1, CCL20, CCL4, CD44*, CD59*, CR1*, DAF*, FYB*, HGF, 0.00000476 23 ICAM1, IFNGR1, IL1A, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, adhesion of blood cells PTPNS1*, SELL, SERPING1, SPP1, TNF, TXN* adhesion of leukocyte ANXA1, CCL3, CCL4, CD44*, CD59*, DAF*, FES, ICAM1, IL8*, cell lines 0.0000064 14 ITGAM*, PLAU*, PTPNS1*, SELL, TNF ANXA1, CCL20, CCL4, CD44*, FYB*, HGF, ICAM1, IFNGR1, IL1A, adhesion of lymphatic 0.00000654 19 IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, PTPNS1*, SELL, SPP1, TNF, system cells TXN* ANXA1, ICAM1, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, SELL, TNF, adhesion of neutrophils 0.0000072 10 TXN* ANXA1, ICAM1, IL1A, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, adhesion of phagocytes 0.0000311 12 PTPNS1*, SELL, TNF, TXN* adhesion of bone ANXA1, CD44*, ICAM1, IL1B*, IL8*, ITGAM*, PLAU*, PLAUR*, SELL, marrow cells 0.0000624 11 TNF, TXN* adhesion of endothelial cells 0.000183 10 CCL3, CCL4, HGF, ICAM1, IL1A, IL1B*, IL8*, SELL, TNF, TXN* ANXA1, CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, IL1A, IL1B*, adhesion of leukocytes 0.000228 17 IL8*, ITGAM*, PLAU*, PLAUR*, SELL, SPP1, TNF, TXN* adhesion of epithelial cell lines 0.000326 7 ANXA1, HGF, IGF1R, ITGAM*, LGALS8*, PLAU*, PLAUR* adhesion of 0.000392 12 CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, IL1A, IL8*, PLAU*, mononuclear leukocytes SELL, SPP1, TNF adhesion of red blood cells 0.000465 6 CD59*, CR1*, DAF*, PTPNS1*, SERPING1, TNF adhesion of CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, PLAU*, SELL, SPP1, lymphocytes 0.000783 10 TNF adhesion of T lymphocytes 0.000866 9 CCL20, CCL4, FYB*, HGF, ICAM1, IFNGR1, PLAU*, SELL, SPP1 adhesion of connective tissue cells 0.00268 9 CD44*, ICAM1, IL1A, IL8*, PLAU*, PLAUR*, PTPNS1*, SELL, TNF adhesion of embryonic cell lines 0.00285 4 HGF, ITGAM*, PLAU*, PLAUR* adhesion of memory T lymphocytes 0.00286 2 CCL20, HGF formation 1.01E-4 - 1.58E-3 19 formation of endothelial tube 0.000101 8 BPI, CD44*, IL8*, PLAU*, PLAUR*, PRKCD, PTEN, TNF BPI, CD44*, ETS2*, GAP43, HGF, ICAM1, IGFBP5, IL1A, IL1RN*, 0.00158 19 IL8*, NPY2R, PLAU*, PLAUR*, PRKCD, PTEN, SELL, SPP1, STAT3, formation of tissue TNF aggregation 2.36E-4 - 2.86E-3 21 ADORA2A, CD24*, CD44*, ENTPD1*, FCER1G, FCGR2A*, FPR1, 0.000236 21 GPR132, GSN, HGF, ICAM1, IGF1R, ITGAM*, LYN, PSEN1, PTEN, aggregation of cells PTPNS1*, PTPRC, SELL, STAT3, TNF aggregation of monocyte-derived 0.00286 2 dendritic cells CD44*, TNF patterning 1.65E-3 - 1.65E-3 15 ALPL, BMP2, BMPR2, GGT1, GSN, IL1A, KL, MMP9, NPY2R, OSM*, patterning of tissue 0.00165 15 PSEN1, SPP1, TAL1, THRA, TNF remodeling 2.32E-3 - 3.55E-3 14 ALPL, BMP2, BMPR2, GGT1, GSN, IL1A, KL, MMP9, NPY2R, OSM*, remodeling of tissue 0.00232 14 SPP1, TAL1, THRA, TNF ALPL, BMP2, BMPR2, GGT1, GSN, IL1A, KL, MMP9, NPY2R, OSM*, remodeling of bone 0.00355 13 SPP1, THRA, TNF resorption 2.60E-3 - 2.60E-3 7 resorption of bone 0.0026 7 GGT1, GSN, IL1A, KL, OSM*, SPP1, TNF activation 2.86E-3 - 2.86E-3 2 activation of cartilage tissue 0.00286 2 IL1A, IL1B* Organismal Survival 6.99E-7 - 2.57E-4 69 death 6.99E-7 - 1.10E-5 58

ADORA2A, ALOX5*, ARG1, CCR1*, CD44*, CR1*, CREBBP, CYBB*, EGR3, ETS2*, FCGR2B*, FES, GGT1, HGF, HIF1A, HP*, IFNAR1, IFNGR1, IGF1R, IGHG1*, IL18R1, IL1R1, IL1RN*, JAK2*, LY96, LYN, 0.000000699 58 MAP4K4*, MMP9, MYB, MYCN, NBS1*, NFE2, NFKB2*, NFKBIA*, NTRK3, OSM*, PFN1, POR, PSEN1, PTEN, PTPN2, REN, SOCS3*, SOD2*, SP1, STAT3, TAL1, TCF3*, TFDP1, TGFA, THRA, TLR4*, death of animal TNF, TNFAIP3*, TNFRSF6, TTPA, TXN*, XRCC4 ADORA2A, ALOX5 , ARG1, CCR1 , CD44 , CR1 , CREBBP, CYBB , EGR3, ETS2*, FCGR2B*, FES, GGT1, HGF, HIF1A, HP*, IFNAR1, IFNGR1, IGF1R, IGHG1*, IL18R1, IL1R1, IL1RN*, JAK2*, LY96, LYN, 0.00000299 55 MAP4K4*, MMP9, MYB, MYCN, NFE2, NFKB2*, NFKBIA*, NTRK3, OSM*, PFN1, POR, PSEN1, PTEN, PTPN2, REN, SOCS3*, SOD2*, SP1, STAT3, TAL1, TCF3*, TFDP1, THRA, TLR4*, TNF, TNFAIP3*, death of rodents TNFRSF6, TXN*, XRCC4 ADORA2A, ALOX5 , ARG1, CCR1 , CD44 , CR1 , CREBBP, CYBB , EGR3, ETS2*, FCGR2B*, FES, GGT1, HIF1A, HP*, IFNAR1, IFNGR1, IGF1R, IGHG1*, IL18R1, IL1R1, IL1RN*, JAK2*, LY96, LYN, 0.000011 53 MAP4K4*, MMP9, MYB, MYCN, NFE2, NFKB2*, NFKBIA*, NTRK3, OSM*, PFN1, POR, PSEN1, PTEN, PTPN2, SOCS3*, SOD2*, SP1, STAT3, TAL1, TCF3*, TFDP1, THRA, TLR4*, TNF, TNFAIP3*, death of mice TNFRSF6, TXN*, XRCC4 survival 1.22E-5 - 2.57E-4 28 ADM, CCL3, CCR1*, CD44*, CR1*, CTSB*, FCGR2B*, GCA, HGF, HP*, ICAM1, IFI16*, IL18R1, MAPKAPK2, MUSK, MYB, NFKBIA*, 0.0000122 28 NTRK3, PIK3CG, PTEN, PTGES, PTX3, REN, STAT3, TAL1, TLR4*, survival of mammals TNF, TNFRSF6 ADM, CCL3, CCR1*, CR1*, CTSB*, FCGR2B*, GCA, HGF, HP*, ICAM1, IFI16*, IL18R1, MAPKAPK2, MUSK, NFKBIA*, NTRK3, 0.0000606 26 PIK3CG, PTEN, PTGES, PTX3, REN, STAT3, TAL1, TLR4*, TNF, survival of rodents TNFRSF6 CCL3, CCR1*, CR1*, CTSB*, FCGR2B*, GCA, HGF, HP*, ICAM1, 0.000257 24 IFI16*, IL18R1, MAPKAPK2, MUSK, NFKBIA*, NTRK3, PIK3CG, survival of mice PTEN, PTGES, PTX3, STAT3, TAL1, TLR4*, TNF, TNFRSF6 Gene Expression 7.39E-7 - 1.46E-3 86 binding 7.39E-7 - 7.39E-7 26 BMP2, CREBBP, DSIPI*, FOSL2*, HGF, HP*, IL1A, IL1B*, IL4R, 0.000000739 26 JAK2*, JAK3*, MAIL, MYB, NFKBIA*, NFKBIE, OSM*, PML*, POR, binding of DNA PRKCD, PTEN, SOCS3*, SP1, TAL1, TNF, TNFRSF6, TXN* expression 7.98E-7 - 7.98E-7 46

ATF3, ATF6*, BTG2*, CD44*, CREBBP, CREM*, ETS2*, ETV7, FCGR1A*, FCGR2A*, FGR, FOSL2*, FPRL1*, HGF, HIF1A, HMGB2, 0.000000798 46 IL1A, IL1B*, JAK2*, MAD*, MAPK14*, MAPKAPK2, MEF2A*, MYOD1, NFKB2*, NFKBIA*, NRIP1, OSM*, PDCD4*, PML*, PPP2R5A, PRIC285*, PSEN1, PTEN, REN, SOCS3*, SP1, SP100*, expression of gene STAT2*, STAT3, STAT5A, TAL1, TCF3*, THRA, TNF, TXN* transcription 3.59E-6 - 1.46E-3 71 ATF3, ATF6*, BTG2*, CD44*, CREBBP, CREM*, ETS2*, ETV7, FCGR1A*, FCGR2A*, FGR, FOSL2*, HGF, HIF1A, HMGB2, IL1A, IL1B*, JAK2*, MAD*, MAPK14*, MAPKAPK2, MEF2A*, MYOD1, 0.00000359 43 NFKB2*, NFKBIA*, NRIP1, OSM*, PDCD4*, PML*, PRIC285*, PSEN1, PTEN, REN, SOCS3*, SP1, SP100*, STAT2*, STAT3, transcription of gene STAT5A, TAL1, TCF3*, THRA, TNF ADORA2A, ATF3, ATF6 , BTG2 , CAMKK2 , CD44 , COPEB, CREBBP, CREM*, DRAP1, DSIPI*, ETS2*, ETV7, FCGR1A*, FCGR2A*, FGR, FOSL2*, HGF, HIF1A, HIVEP2, HMGB2, IL1A, IL1B*, IRF7, IVNS1ABP*, JAK2*, KLF5, LITAF, MAD*, MAPK14*, MAPKAPK2, MEF2A*, MLLT2*, MLLT6, MTF1*, MUSK, MYB, MYCN, 0.00146 71 MYOD1, NFE2, NFIL3, NFKB2*, NFKBIA*, NFYA, NRIP1, OSM*, PAX8, PDCD4*, PML*, PRIC285*, PSEN1, PTEN, REN, SOCS3*, SP1, SP100*, STAT2*, STAT3, STAT5A, STAT5B*, TAL1, TBX2, TCF3*, TFDP1, TFEC*, THRA, TLE3*, TNF, TNRC11*, TRIM22, transcription ZNF281 activation 8.72E-6 - 8.72E-6 29 BCL3*, CD44*, CREBBP, CREM*, ETS2*, FOSL2*, HGF, IL1A, IL4R, IRF7, MAD*, MAPK14*, MAPKAPK2, MTF1*, MYB, MYOD1, NFE2, 0.00000872 29 NRIP1, OSM*, PML*, REN, SOCS3*, SP1, STAT2*, STAT3, TAL1, activation of gene TCF3*, TGFA, TLR4* transactivation 1.42E-3 - 1.42E-3 13 CD44*, CREBBP, CREM*, FOSL2*, IL1A, IRF7, MAPK14*, transactivation of gene 0.00142 13 MAPKAPK2, PML*, STAT2*, STAT3, TAL1, TCF3* Reproductive System Diseas1.18E-6 - 3.59E-3 28 cell death 1.18E-6 - 1.18E-6 15 cell death of prostate ALOX5*, BMX, CASP1*, CFLAR*, EDN1, ETS2*, IGFBP5, PRKCD, cancer cell lines 0.00000118 15 PTEN, SLC5A5, STAT3, TGFA, TNF, TNFRSF6, TXN* invasion 2.50E-4 - 2.85E-3 8 invasion of gonadal cell lines 0.00025 4 EDN1, PLAU*, PTP4A1, TNF invasion of ovarian cancer cell lines 0.000587 3 EDN1, PLAU*, TNF invasion of prostate cancer cell lines 0.00285 4 CTSB*, ETS2*, PLAUR*, PTEN growth 3.43E-4 - 9.02E-4 18 growth of breast cancer BMX, HGF, IGF1R, IL1B*, OSM*, PFN1, PLAU*, PRKCD, PTEN, cell lines 0.000343 12 TGFA, TNF, TXN* growth of prostate BMX, CASP1*, CEACAM1*, CREM*, ETS2*, HGF, IGFBP5, PTEN, cancer cell lines 0.000902 10 STAT3, TGFA G1 phase 2.86E-3 - 2.86E-3 2 arrest in G1 phase of prostate cancer cell 0.00286 2 lines CREM*, PTEN cell movement 3.16E-3 - 3.16E-3 8 cell movement of breast cancer cell lines 0.00316 8 IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, STAT3, TGFA migration 3.59E-3 - 3.59E-3 7 migration of breast cancer cell lines 0.00359 7 IGF1R, OSM*, PLAU*, PLAUR*, SDCBP, SPP1, TGFA Immunological Disease 1.41E-6 - 4.20E-4 30 immunological disease 1.41E-6 - 1.41E-6 30 BCL3*, CASP1*, CCL3, CCR1*, CFLAR*, FCAR*, FCGR2B*, ICAM1, IFNAR1, IFNGR1, IFNGR2, IGHG1*, IL1A, IL4R, IL8*, JAK3*, KL, 0.00000141 30 LYN, MMP9, NFKBIA*, PRKR, PTPNS1*, PTPRC, SELL, SPP1, immunological disease STAT5A, STAT5B*, TAP2, TNF, TNFRSF6 insulin-dependent diabetes mellitus 5.28E-5 - 5.28E-5 9 insulin-dependent CCL3, ICAM1, IFNGR1, IFNGR2, IGHG1*, IL1A, TAP2, TNF, diabetes mellitus 0.0000528 9 TNFRSF6 autoimmune disease 9.34E-5 - 9.34E-5 16 CCL3, CCR1*, CFLAR*, FCGR2B*, ICAM1, IFNGR1, IFNGR2, autoimmune disease 0.0000934 16 IGHG1*, IL1A, LYN, MMP9, SELL, SPP1, TAP2, TNF, TNFRSF6 splenomegaly 4.20E-4 - 4.20E-4 7 splenomegaly 0.00042 7 BCL3*, IFNAR1, JAK3*, NFKBIA*, STAT5A, STAT5B*, TNFRSF6 Free Radical Scavenging 2.33E-6 - 4.65E-4 19 production 2.33E-6 - 2.33E-6 13 production of ARG1, CYBA, CYBB*, EDN1, FGR, FPR1, IL1B*, IL8*, IL8RA, superoxide radical 0.00000233 13 ITGAM*, NCF1*, SOD2*, TNF quantity 2.70E-4 - 2.70E-4 8 quantity of reactive oxygen species 0.00027 8 CYBB*, EDN1, GGT1, HGF, IL1B*, NFE2, SOD2*, TNF release 4.65E-4 - 4.65E-4 6 release of superoxide radical 0.000465 6 FGR, IL1B*, LYN, PLAU*, PLAUR*, TNF Dermatological Diseases and3.25E-6 - 1.40E-4 17 dermatological disease 3.25E-6 - 3.25E-6 17 CASP1*, DAF*, ICAM1, IFNGR2, IGHG1*, IL1A, IL1B*, IL4R, LYN, 0.00000325 17 NFKBIA*, PRKR, PTPNS1*, PTPRC, SELL, TNF, TNFRSF6, dermatological disease TNFSF13B* dermatitis 5.28E-5 - 5.28E-5 9 dermatitis 0.0000528 9 CASP1*, DAF*, IFNGR2, IL1A, IL1B*, IL4R, NFKBIA*, PRKR, TNF systemic lupus erythematosus 1.40E-4 - 1.40E-4 7 systemic lupus erythematosus 0.00014 7 ICAM1, LYN, PTPNS1*, PTPRC, TNF, TNFRSF6, TNFSF13B* Cell Morphology 3.99E-6 - 3.94E-3 31 shape change 3.99E-6 - 4.26E-4 27 shape change of neutrophils 0.00000399 6 FCAR*, FGR, ITGAM*, LYN, SELL, TNF shape change of granulocytes 0.0000153 8 CCL3, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF shape change of leukocytes 0.0000408 9 CCL3, CD44*, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF shape change of lymphatic system cells 0.0000862 9 CCL3, CD44*, FCAR*, FGR, IL8*, ITGAM*, LYN, SELL, TNF CCL3, CD44*, FCAR*, FGD4, FGR, GPR132, GRID2, GSN, HGF, HTR4, IL8*, ITGAM*, LGALS8*, LYN, MAPK14*, PFN1, PLAU*, 0.000426 27 PLAUR*, PRKCD, PTEN, PTGER3, PTPNS1*, SELL, SPP1, STAT3, shape change TNF, TNFRSF6 cell spreading 4.54E-5 - 6.90E-4 16 cell spreading of neutrophils 0.0000454 5 FCAR*, FGR, ITGAM*, LYN, TNF cell spreading of leukocytes 0.000244 6 CD44*, FCAR*, FGR, ITGAM*, LYN, TNF cell spreading of lymphatic system cells 0.000341 6 CD44*, FCAR*, FGR, ITGAM*, LYN, TNF CD44*, FCAR*, FGR, GPR132, GRID2, HGF, ITGAM*, LGALS8*, cell spreading 0.00069 16 LYN, MAPK14*, PFN1, PLAU*, PTPNS1*, SPP1, STAT3, TNF contraction 2.86E-3 - 2.86E-3 2 contraction of mesangial cells 0.00286 2 EDN1, PTX3 deformability 2.86E-3 - 2.86E-3 2 deformability of neutrophils 0.00286 2 IL8*, TNF ruffling 2.86E-3 - 2.86E-3 2 ruffling of smooth muscle cells 0.00286 2 PLAU*, PLAUR* size 3.94E-3 - 3.94E-3 4 size of tumor cell lines 0.00394 4 MAD*, MAPK14*, PTPRC, TNFRSF6 Cellular Compromise 3.99E-6 - 2.86E-3 13 degranulation 3.99E-6 - 1.84E-3 10 degranulation of neutrophils 0.00000399 6 CCL3, CCL4, CXCL2*, IL8*, PLAUR*, TNF CCL3, CCL4, CXCL2*, FCER1G, FCGR2B*, FPR1, IL8*, LYN, degranulation of cells 0.000309 10 PLAUR*, TNF degranulation of leukocytes 0.00184 7 CCL3, CCL4, CXCL2*, IL8*, LYN, PLAUR*, TNF damage 8.25E-4 - 8.25E-4 4

damage of mitochondria 0.000825 4 IL1B*, SOD2*, TNF, TNFRSF6 deformability 2.86E-3 - 2.86E-3 2 deformability of neutrophils 0.00286 2 IL8*, TNF Lipid Metabolism 3.99E-6 - 3.94E-3 36 exposure 3.99E-6 - 3.99E-6 6 exposure of phospholipid 0.00000399 6 GSN, IL1A, IL1B*, PLSCR1*, PLSCR2, TNF induction 3.89E-5 - 3.89E-5 4 induction of prostaglandin 0.0000389 4 EDN1, IL1A, IL1B*, TNF release 6.56E-5 - 6.56E-5 14 ALOX5AP, CTSB*, EDN1, FCER1G, IL1A, IL1B*, IL1RN*, IL8*, LYN, release of eicosanoid 0.0000656 14 MAPK14*, PRKCD, TGFA, TNF, TNFRSF6 metabolism 8.69E-5 - 3.14E-3 6 leukotriene metabolism 0.0000869 5 ALOX5*, ALOX5AP, CYP4F2, NCF1*, TNF metabolism of eicosanoid 0.00314 6 ALOX5*, ALOX5AP, CYP4F2, NCF1*, PTGES, TNF synthesis 4.20E-4 - 3.30E-3 18 synthesis of phosphatidic acid 0.00042 7 FCGR2A*, IL8*, PLSCR1*, PLSCR2, PTX3, SH3GLB1*, TNF synthesis of phosphatidylserine 0.00286 2 PLSCR1*, PLSCR2 ACLY*, ADM, ALOX5*, ALOX5AP, FACL3*, FCGR2A*, IL1A, IL1B*, 0.0033 18 IL8*, PLAU*, PLSCR1*, PLSCR2, PTX3, RDH8, SH3GLB1*, TNF, synthesis of lipid TNFRSF6, UGCG* distribution 5.77E-4 - 5.77E-4 5 distribution of lipid 0.000577 5 GSN, MARCKS*, PLSCR2, TNF, UGCG* quantity 1.50E-3 - 3.42E-3 15 quantity of eicosanoid 0.0015 8 ALOX5*, EDN1, IL1A, IL1B*, IL1R2*, PTGES, TGFA, TNF quantity of prostaglandin E2 0.00258 6 EDN1, IL1A, IL1B*, IL1R2*, PTGES, TGFA quantity of phosphatidic FCER1G, FCGR2B*, FES, IL1A, IL1B*, IL8*, PIK3CG, PTEN, TNF, acid 0.00279 10 TNFRSF6 quantity of prostanoid 0.00286 2 IL1A, TNF quantity of phosphatidylinositol- 0.00342 5 3,4,5-trisphosphate FCER1G, FCGR2B*, IL8*, PIK3CG, PTEN redistribution 1.98E-3 - 1.98E-3 4 redistribution of lipid 0.00198 4 GSN, MARCKS*, TNF, UGCG* stimulation 2.70E-3 - 2.70E-3 3 stimulation of prostaglandin E2 0.0027 3 IL1A, IL1B*, TNF production 2.75E-3 - 3.06E-3 8 production of prostaglandin 0.00275 8 EDN1, IL1B*, IL1R2*, IL1RN*, IL8*, LYN, PTGES, TNF production of prostaglandin E2 0.00306 7 EDN1, IL1B*, IL1R2*, IL1RN*, IL8*, PTGES, TNF generation 2.86E-3 - 2.86E-3 2 generation of glycosphingolipid 0.00286 2 TNF, UGCG* glycosylation 2.86E-3 - 2.86E-3 2 glycosylation of ceramide 0.00286 2 TNFRSF6, UGCG* movement 2.86E-3 - 2.86E-3 2 movement of phosphatidylserine 0.00286 2 PLSCR1*, PLSCR2 formation 3.94E-3 - 3.94E-3 4 formation of ceramide 0.00394 4 IL1B*, TNF, TNFRSF6, UGCG* Cellular Growth and Prolifera8.96E-6 - 3.94E-3 135 proliferation 8.96E-6 - 3.59E-3 109 ADM, ANXA1, ARG1, ARHG, ARID3A, BCL2A1, BCL3*, BMP2, BMX, BPI, BST2, BTG2*, CCL20, CCL3, CCR1*, CD44*, CDC27, CEACAM1*, COPEB, CR1*, CTSB*, EDN1, EFNA1, ETS2*, FCGR2B*, FES, FPRL1*, FYB*, GBP1, GGT1, GPR132, HGF, HHEX, HIF1A, ICAM1, IFI16*, IFITM1*, IFNAR1, IGF1R, IGFBP5, IGHG1*, IL13RA1*, IL1A, IL1B*, IL1R1, IL4R, IL8*, IL9R, INDO, ISG20, IVNS1ABP*, JAK2*, JAK3*, KLF5, LAMP3, LDHA, LY96, LYN, MAD*, 0.00000896 109 MAPK14*, MAPKAPK2, MMP9, MYB, MYCN, NCF1*, NFE2, NFKBIA*, NTRK3, OSM*, PDCD1LG1*, PEG10, PIK3AP1, PIK3CG, PLAU*, PLAUR*, PML*, PRKCD, PRKR, PROK2, PSEN1, PTEN, PTGES, PTPN2, PTPNS1*, PTPRC, PTPRJ, PTPRO, REN, RIPK2, SCAP2*, SLC12A6, SOCS3*, SOD2*, SPP1, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, TGFA, TLR4*, TNF, TNFRSF6, TNFSF13B*, proliferation of cells TP53I11*, TXN*, UGCG*, WARS, ZNF147* CCL20, CCL3, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL8*, IL9R, INDO, JAK2*, JAK3*, LY96, LYN, MMP9, PDCD1LG1*, PIK3AP1, PIK3CG, 0.0000101 43 PRKCD, PRKR, PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, PTPRO, proliferation of blood RIPK2, SOCS3*, SPP1, STAT5A, STAT5B*, TLR4*, TNF, TNFRSF6, cells TNFSF13B*, TXN*

CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000389 40 MMP9, NFE2, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, proliferation of PTEN, PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT3, lymphatic system cells STAT5A, STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, MMP9, 0.0000443 37 PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, PTPN2, proliferation of PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, STAT5B*, lymphocytes TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CCL20, CD44*, CEACAM1*, CR1*, ETS2*, FCGR2B*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL4R, IL9R, INDO, JAK3*, LY96, LYN, 0.0000521 38 MMP9, PDCD1LG1*, PIK3AP1, PIK3CG, PRKCD, PRKR, PTEN, proliferation of PTPN2, PTPNS1*, PTPRC, PTPRJ, RIPK2, SPP1, STAT5A, leukocytes STAT5B*, TLR4*, TNF, TNFRSF6, TNFSF13B*, TXN* CD44*, CEACAM1*, CR1*, ETS2*, FYB*, ICAM1, IFNAR1, IGHG1*, IL1A, IL1B*, IL9R, INDO, JAK3*, MMP9, PDCD1LG1*, PIK3CG, proliferation of T 0.0000923 29 PRKR, PTEN, PTPN2, PTPNS1*, PTPRJ, RIPK2, SPP1, STAT5A, lymphocytes STAT5B*, TLR4*, TNF, TNFRSF6, TXN* ARID3A, BMP2, CD44*, EDN1, GGT1, HGF, IGFBP5, IL1B*, LYN, proliferation of 0.000236 21 MYCN, NTRK3, OSM*, PML*, PTPN2, PTPRC, STAT3, STAT5A, connective tissue cells TGFA, TNF, TNFRSF6, TXN* proliferation of B CD44*, FCGR2B*, IFNAR1, IL4R, LY96, LYN, PIK3AP1, PRKCD, lymphocytes 0.000388 16 PTEN, PTPN2, PTPRC, STAT5A, TLR4*, TNF, TNFSF13B*, TXN* CD44*, HGF, IGF1R, IL13RA1*, IL1A, IL1B*, IL8*, IL9R, JAK2*, proliferation of 0.000433 22 JAK3*, LDHA, LYN, MAPK14*, MYB, NFE2, OSM*, PLAU*, SPP1, leukocyte cell lines STAT3, STAT5A, STAT5B*, TNF proliferation of smooth ADM, ARG1, BMP2, EDN1, HGF, IL1B*, MYB, NCF1*, PLAU*, SPP1, muscle cells 0.000451 11 TNF proliferation of leukemia CD44*, IGF1R, IL1A, IL1B*, LYN, MAPK14*, MYB, NFE2, PLAU*, cell lines 0.00135 10 TNF

proliferation of liver cells 0.0015 8 HGF, IGF1R, IL1B*, PEG10, PML*, REN, TGFA, TNF proliferation of endothelial cell lines 0.00359 7 BMX, EDN1, HGF, HHEX, IL8*, PTEN, TNF growth 6.11E-5 - 2.86E-3 69 ADM, ANXA1, ATF3, BCL2A1, BMP2, BMX, BTG2 , CASP1 , CCL3, CCL4, CEACAM1*, CREM*, EDN1, EFNA1, ETS2*, FES, GADD45B*, GAP43, GGT1, GRID2, HGF, HIF1A, HIP1*, IER3, IFNAR1, IGF1R, IGFBP5, IGHG1*, IL1A, IL1B*, IL1RN*, IVNS1ABP*, JAK2*, JAK3*, 0.0000611 69 LDHA, MAD*, MLLT6, MYCN, NTN2L, NTRK3, OSM*, PEG10, PFN1, PLAU*, PLAUR*, PLSCR1*, PML*, POR, PPP1R15A*, PRKCD, PRKR, PSEN1, PTCRA, PTEN, SOCS3*, SOD2*, SP1, SPP1, STAT3, STAT5A, STAT5B*, TAL1, TCF3*, TGFA, TNF, TNFAIP6*, growth of cells TNFRSF6, TXN*, ZNF363 growth of breast cancer BMX, HGF, IGF1R, IL1B*, OSM*, PFN1, PLAU*, PRKCD, PTEN, cell lines 0.000343 12 TGFA, TNF, TXN* growth of brain cells 0.000479 4 IL1A, IL1B*, IL1RN*, NTN2L growth of breast cell BMX, HGF, IER3, IGF1R, IL1B*, JAK2*, OSM*, PFN1, PLAU*, lines 0.000678 14 PRKCD, PTEN, TGFA, TNF, TXN* growth of prostate BMX, CASP1*, CEACAM1*, CREM*, ETS2*, HGF, IGFBP5, PTEN, cancer cell lines 0.000902 10 STAT3, TGFA growth of epithelial cell BMX, HGF, IGF1R, IL1B*, JAK2*, OSM*, PLAU*, PRKCD, PTEN, lines 0.0013 12 TGFA, TNF, TXN* ADM, ANXA1, BMX, BTG2*, CASP1*, CEACAM1*, CREM*, EDN1, ETS2*, FES, GAP43, GGT1, HGF, IER3, IFNAR1, IGF1R, IGFBP5, growth of tumor cell 0.0017 34 IL1B*, OSM*, PFN1, PLAU*, PLAUR*, POR, PRKCD, PTEN, lines SOCS3*, SOD2*, SP1, STAT3, TAL1, TCF3*, TGFA, TNF, TXN* growth of prostate cell BMX, CASP1*, CEACAM1*, CREM*, ETS2*, HGF, IGFBP5, PTEN, lines 0.00197 10 STAT3, TGFA growth of pituitary cells 0.0027 3 IL1A, IL1B*, IL1RN* growth of hepatic stellate cells 0.00286 2 EDN1, TNF induction 1.53E-4 - 2.86E-3 18 induction of chondrocytes 0.000153 3 BMP2, IL1B*, TNF induction of connective tissue cells 0.00103 7 BMP2, EDN1, IL1B*, NTRK3, OSM*, TNF, TXN* ADM, BMP2, CEACAM1*, EDN1, HGF, IGFBP5, IGHG1*, IL1B*, IL8*, induction of cells 0.00236 18 JAK2*, MYB, NTRK3, OSM*, REN, SPP1, TGFA, TNF, TXN* induction of osteocytes 0.00286 2 EDN1, TNF stimulation 2.50E-4 - 3.94E-3 25 stimulation of liver cells 0.00025 5 HGF, IL1B*, REN, TGFA, TNF stimulation of hepatoma cell lines 0.00025 4 HGF, IL1A, IL1B*, TNF stimulation of liver cell lines 0.00025 4 HGF, IL1A, IL1B*, TNF stimulation of synovial cells 0.00025 4 IL1A, IL1B*, OSM*, TNF stimulation of osteocytes 0.000479 4 EDN1, IL1A, PLAU*, TNF stimulation of hepatocytes 0.000825 4 HGF, IL1B*, TGFA, TNF stimulation of kidney cells 0.000825 4 EDN1, HGF, IL1B*, TNF stimulation of BMP2, CAMP, EDN1, IL1A, IL1B*, NTRK3, OSM*, PLAU*, TNF, connective tissue cells 0.00104 10 TXN* ADM, BMP2, CAMP, CEACAM1*, CXCL2*, EDN1, HGF, IGFBP5, IGHG1*, IL1A, IL1B*, IL8*, JAK2*, MYB, NTRK3, OSM*, 0.00124 25 PDCD1LG1*, PLAU*, PRKCG, REN, SPP1, TGFA, TLR4*, TNF, stimulation of cells TXN* stimulation of carcinoma cell lines 0.00286 2 IL1B*, TNF stimulation of lung cancer cell lines 0.00286 2 IL1B*, TNF stimulation of lung cell lines 0.00286 2 IL1B*, TNF stimulation of osteoblasts 0.00286 2 EDN1, PLAU* stimulation of muscle cells 0.00394 4 EDN1, IL1B*, IL8*, TNF hypertrophy 1.35E-3 - 1.35E-3 10 hypertrophy of heart COL9A2, CTSB*, EDN1, IER3, MAPK14*, MYOD1, OSM*, PLAU*, cells 0.00135 10 PTEN, S100A6 Neurological Disease 9.06E-6 - 2.86E-3 23 cell death 9.06E-6 - 9.06E-6 12 cell death of brain CASP1*, CD59*, CFLAR*, HGF, HIP1*, IGF1R, PRKCD, PSEN1, cancer cell lines 0.00000906 12 PTEN, PTPNS1*, TNF, TNFRSF6 invasion 3.41E-4 - 1.56E-3 6 invasion of nervous tissue cell lines 0.000341 6 CTSB*, IGF1R, MMP9, MYCN, PLAUR*, PTEN invasion of brain cancer cell lines 0.00156 5 CTSB*, IGF1R, MMP9, PLAUR*, PTEN migration 1.06E-3 - 1.06E-3 6 migration of brain cancer cell lines 0.00106 6 HGF, MMP9, PLAU*, PLAUR*, PTEN, PTPNS1* G0/G1 transition 1.41E-3 - 1.41E-3 3 arrest in G0/G1 transition of brain 0.00141 3 cancer cell lines HGF, PLAUR*, PTEN damage 2.70E-3 - 2.70E-3 3 damage of brain 0.0027 3 IL1B*, IL1R1, IL1RN* activation 2.86E-3 - 2.86E-3 2 activation of brain cancer cell lines 0.00286 2 LY96, TNF encephalitis 2.86E-3 - 2.86E-3 2 encephalitis 0.00286 2 ALOX5*, NFKB2* Connective Tissue Developm1.02E-5 - 2.86E-3 50 quantity 1.02E-5 - 1.02E-5 22 BCL2A1, CCL3, GGT1, ICAM1, IFNAR1, IFNGR1, IL1A, IL1B*, quantity of connective 0.0000102 22 IL1RN*, IL8*, JAK3*, KL, MMP9, NFKB2*, PIK3CG, PLAU*, PML*, tissue cells REN, SELL, SPP1, THRA, TNF binding 3.75E-5 - 3.75E-5 12 binding of connective BPI, CCL3, CCR1*, FPR1, ICAM1, IL1A, IL8*, ITGAM*, PLAUR*, tissue cells 0.0000375 12 PTPRC, SELL, TNF activation 1.49E-4 - 1.49E-4 16 activation of connective CCL3, CCL4, EDN1, FCGR2B*, GGT1, ICAM1, IGHG1*, IL1A, IL1B*, tissue cells 0.000149 16 IL1RN*, IL8*, LY96, NPY2R, PTGER3, TLR4*, TNF stimulation 2.50E-4 - 1.04E-3 10 stimulation of synovial cells 0.00025 4 IL1A, IL1B*, OSM*, TNF stimulation of BMP2, CAMP, EDN1, IL1A, IL1B*, NTRK3, OSM*, PLAU*, TNF, connective tissue cells 0.00104 10 TXN* induction 1.03E-3 - 1.03E-3 7 induction of connective tissue cells 0.00103 7 BMP2, EDN1, IL1B*, NTRK3, OSM*, TNF, TXN* response 1.35E-3 - 1.35E-3 6 response of connective tissue cells 0.00135 6 CXCL2*, FCGR2A*, FCGR2B*, PGLYRP, TLR4*, TNFRSF6 phagocytosis 1.56E-3 - 1.56E-3 5 phagocytosis of connective tissue cells 0.00156 5 FCGR2A*, FCGR2B*, PGLYRP, TLR4*, TNFRSF6 chemotaxis 1.61E-3 - 1.61E-3 12 chemotaxis of CAMP, CCL3, CCL4, FPR1, FPRL1*, HGF, IL1B*, LYN, PIK3CG, connective tissue cells 0.00161 12 PLAU*, PLAUR*, TNF adhesion 2.68E-3 - 2.68E-3 9 adhesion of connective tissue cells 0.00268 9 CD44*, ICAM1, IL1A, IL8*, PLAU*, PLAUR*, PTPNS1*, SELL, TNF growth 2.86E-3 - 2.86E-3 2 growth of hepatic stellate cells 0.00286 2 EDN1, TNF Nucleic Acid Metabolism 1.05E-5 - 1.05E-5 13 incorporation 1.05E-5 - 1.05E-5 13 incorporation of ATF3, BMP2, BMPR2, CREM*, EDN1, IGF1R, IGFBP5, PIK3CG, thymidine 0.0000105 13 PRKCD, PTPNS1*, TNF, TNFRSF6, TNFSF13B* Organismal Injury and Abnor 1.26E-5 - 2.86E-3 21 destabilization 1.26E-5 - 1.26E-5 19 ADM, ADORA2A, CLCN2, CTSB*, FCGR1A*, FGR, IL1B*, IL1R1, 0.0000126 19 IL1RN*, KL, MMP9, NCF1*, OSM*, PLAU*, REN, TNF, TNFRSF6, destabilization of organ TNFSF13B*, TXN* damage 2.90E-5 - 2.90E-5 17 ADM, ADORA2A, CTSB*, FCGR1A*, FGR, IL1B*, IL1R1, IL1RN*, KL, damage of organ 0.000029 17 MMP9, NCF1*, OSM*, PLAU*, REN, TNF, TNFRSF6, TXN* leakage 2.86E-3 - 2.86E-3 2 leakage of bodily fluid 0.00286 2 IL1R2*, IL8* Cellular Development 1.76E-5 - 3.94E-3 93 differentiation 1.76E-5 - 3.94E-3 64 BMP2, CCR1*, ETS2*, IFI16*, IGF1R, IRF7, JAK2*, JAK3*, LYN, myeloid blood cell 0.0000176 21 MYB, MYOD1, PLSCR1*, PML*, PTPRC, SFXN1, SOCS3*, SPP1, differentiation STAT5A, STAT5B*, TAL1, TNF BMP2, CCL3, ETS2*, FCGR2B*, IFI16*, IFNGR2, IGF1R, IGHG1*, IL1B*, IRF7, JAK2*, JAK3*, LYN, MAPK14*, MYB, MYOD1, NFYA, differentiation of blood 0.000159 30 PIK3CG, PLSCR1*, PML*, PTPRC, RIPK2, SFXN1, SOCS3*, cells STAT5A, STAT5B*, TAL1, TCF3*, TNF, TNFSF13B* differentiation of epithelial cell lines 0.000479 4 JAK2*, MAPK14*, SPP1, TNF BMP2, BMPR2, BMX, BTG2*, CCL3, CCR1*, CREBBP, CTSB*, EDN1, ETS2*, FCGR2B*, FES, GADD45B*, GSN, HGF, HHEX, HRB*, IFI16*, IFNGR2, IGF1R, IGFBP5, IGHG1*, IL1A, IL1B*, IRF7, 0.000825 64 ITGAM*, JAK2*, JAK3*, LYN, MAD*, MAPK14*, MYB, MYOD1, NAPA, NFYA, NTRK3, OSM*, PIK3CG, PLAU*, PLAUR*, PLSCR1*, PML*, PRKCD, PSEN1, PTPRC, PTPRJ, QKI, RGS6, RIPK2, S100A4, SFXN1, SOCS3*, SPP1, STAT3, STAT5A, STAT5B*, TAL1, differentiation of cells TCF3*, TGFA, THRA, TLR4*, TNF, TNFSF13B*, WNT3 differentiation of breast cell lines 0.000825 4 JAK2*, MAPK14*, OSM*, SPP1 differentiation of osteoclasts 0.00219 7 BMP2, IGHG1*, IL1A, IL1B*, SOCS3*, TLR4*, TNF CCL3, ETS2*, FCGR2B*, IFI16*, IFNGR2, IGF1R, IGHG1*, IRF7, differentiation of 0.00263 23 JAK3*, LYN, MAPK14*, MYB, MYOD1, NFYA, PIK3CG, PLSCR1*, leukocytes PML*, RIPK2, STAT5A, TAL1, TCF3*, TNF, TNFSF13B* BMP2, CCL3, ETS2*, FCGR2B*, IFI16*, IFNGR2, IGF1R, IGHG1*, IRF7, JAK3*, LYN, MAPK14*, MYB, MYOD1, NFYA, PIK3CG, differentiation of 0.0027 25 PLSCR1*, PML*, RIPK2, SOCS3*, STAT5A, TAL1, TCF3*, TNF, lymphatic system cells TNFSF13B* differentiation of BMP2, CREBBP, FES, IGF1R, ITGAM*, JAK3*, MAPK14*, MYB, leukocyte cell lines 0.00274 14 OSM*, PML*, PRKCD, SOCS3*, STAT3, TAL1 differentiation of mesenchymal cells 0.00394 4 BMP2, EDN1, MAPK14*, TGFA development 6.11E-5 - 2.50E-3 48 BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of 0.0000611 21 JAK3*, LYN, NFKB2*, NFYA, OSM*, PTPN2, PTPRC, STAT5A, leukocytes TAL1, TAPBP, TCF3*, TNFSF13B* BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of 0.000114 20 JAK3*, LYN, NFKB2*, OSM*, PTPN2, PTPRC, STAT5A, TAL1, lymphocytes TAPBP, TCF3*, TNFSF13B* BMP2, BST1, CCL4, CD24*, ECE1, EFNA1, EGR3, FCER1G, FGD4, FOSL2*, GAP43, GRID2, HGF, HIF1A, HRB*, IFNAR1, IFNGR2, 0.000138 48 IGF1R, IL1A, IL1R1, IL4R, IL8*, JAK2*, JAK3*, LYN, MAP4K4*, MMP9, MYB, MYOD1, NFKB2*, NFKBIA*, NFYA, NTRK3, OSM*, PFN1, PLAU*, PTCRA, PTPN2, PTPRC, STAT5A, STAT5B*, TAL1, development of cells TAPBP, TCF3*, TGFA, TNF, TNFAIP6*, TNFSF13B* BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of 0.000183 22 JAK3*, LYN, NFKB2*, NFYA, OSM*, PTPN2, PTPRC, STAT5A, lymphatic system cells TAL1, TAPBP, TCF3*, TNF, TNFSF13B* BST1, CD24*, EFNA1, EGR3, FCER1G, HIF1A, IFNGR2, IL1A, IL4R, development of blood 0.000253 22 JAK3*, LYN, MYB, NFKB2*, NFYA, OSM*, PTPN2, PTPRC, STAT5A, cells TAL1, TAPBP, TCF3*, TNFSF13B* development of embryonic cell lines 0.00198 4 BMP2, HGF, NFKBIA*, TGFA development of T EFNA1, EGR3, FCER1G, IFNGR2, IL1A, IL4R, JAK3*, OSM*, lymphocytes 0.0025 13 PTPRC, STAT5A, TAL1, TAPBP, TCF3* maturation 7.28E-5 - 2.46E-4 14 maturation of dendritic cells 0.0000728 7 CD44*, FCGR2B*, IFNAR1, IL1A, TLR4*, TNF, TNFRSF6 maturation of lymphatic CD44*, FCGR2B*, HIF1A, IFNAR1, IL1A, NFE2, PML*, PTCRA, system cells 0.000246 14 PTPNS1*, PTPRC, TCF3*, TLR4*, TNF, TNFRSF6 hematopoiesis 2.85E-3 - 2.85E-3 4 hematopoiesis of leukocytes 0.00285 4 JAK3*, NFYA, PTPN2, TCF3* Organismal Development 1.76E-5 - 2.86E-3 36 differentiation 1.76E-5 - 1.76E-5 21 BMP2, CCR1*, ETS2*, IFI16*, IGF1R, IRF7, JAK2*, JAK3*, LYN, myeloid blood cell 0.0000176 21 MYB, MYOD1, PLSCR1*, PML*, PTPRC, SFXN1, SOCS3*, SPP1, differentiation STAT5A, STAT5B*, TAL1, TNF myelopoiesis 5.28E-5 - 5.28E-5 9 CCL3, CCL4, CXCL2*, JAK2*, PML*, PTPN2, SOCS3*, STAT5A, myelopoiesis 0.0000528 9 STAT5B* hematopoiesis 1.45E-4 - 1.45E-4 35 BMP2, CCL3, CCL4, CCR1*, CXCL2*, ETS2*, FCGR2B*, HHEX, IFI16*, IFNGR2, IGF1R, IGHG1*, IRF7, JAK2*, JAK3*, LYN, 0.000145 35 MAPK14*, MYB, MYOD1, NFYA, PIK3CG, PLSCR1*, PML*, PTPN2, PTPRC, RIPK2, SFXN1, SOCS3*, SPP1, STAT5A, STAT5B*, TAL1, hematopoiesis TCF3*, TNF, TNFSF13B* erythropoiesis 2.50E-4 - 2.50E-4 4 erythropoiesis of mice 0.00025 4 JAK2*, SOCS3*, STAT5A, STAT5B* angiogenesis 2.86E-3 - 2.86E-3 2 angiogenesis of peritoneum 0.00286 2 IL1B*, TNF permeability 2.86E-3 - 2.86E-3 2 permeability of peritoneum 0.00286 2 IL1B*, TNF Hematological Disease 2.19E-5 - 2.86E-3 54 inflammation 2.19E-5 - 2.19E-5 8 inflammation of granulocytes 0.0000219 8 CXCL2*, FCAR*, FGR, ITGAM*, LYN, PIK3CG, TNF, TNFRSF6 hematological disease 2.72E-5 - 2.72E-5 24 BCL3*, CAMP, CASP1*, CCL3, CYBA, CYBB*, F5*, FCGR1A*, FCGR2A*, G6PD, IFNAR1, IFNGR1, IL1B*, JAK2*, JAK3*, NCF1*, 0.0000272 24 NFKBIA*, NT5C3, PTPNS1*, SOD2*, STAT5A, STAT5B*, TNFRSF6, hematological disease TRPM6* survival 1.15E-4 - 1.15E-4 6 survival of leukemia cell lines 0.000115 6 IL1A, LYN, PML*, TNF, TNFRSF6, TXN* leukocytosis 2.44E-4 - 2.44E-4 6 leukocytosis 0.000244 6 IL1B*, IL8*, NFKBIA*, PLSCR1*, STAT3, TNF splenomegaly 4.20E-4 - 4.20E-4 7 splenomegaly 0.00042 7 BCL3*, IFNAR1, JAK3*, NFKBIA*, STAT5A, STAT5B*, TNFRSF6 chronic granulomatous disease 5.87E-4 - 5.87E-4 3 chronic granulomatous disease 0.000587 3 CYBA, CYBB*, NCF1* cell death 1.05E-3 - 1.05E-3 18 CD24*, CD59*, CFLAR*, FGR, GSN, IFNAR1, ITGAM*, LYN, cell death of leukemia 0.00105 18 MAPK14*, NFIL3, NFKBIA*, PML*, TAL1, TCF3*, TGFA, TNF, cell lines TNFAIP3*, TNFRSF6 hemolytic anemia 1.32E-3 - 1.32E-3 4 hemolytic anemia 0.00132 4 G6PD, IFNAR1, NT5C3, TNFRSF6 neutrophilia 1.32E-3 - 1.32E-3 4 neutrophilia 0.00132 4 IL1B*, IL8*, STAT3, TNF proliferation 1.35E-3 - 1.35E-3 10 proliferation of leukemia CD44*, IGF1R, IL1A, IL1B*, LYN, MAPK14*, MYB, NFE2, PLAU*, cell lines 0.00135 10 TNF anemia 2.38E-3 - 2.38E-3 8 G6PD, IFNAR1, JAK2*, NT5C3, SOD2*, STAT5A, STAT5B*, anemia 0.00238 8 TNFRSF6 adhesion 2.70E-3 - 2.70E-3 3 adhesion of leukemia cells 0.0027 3 CD44*, ICAM1, SELL cell movement 2.86E-3 - 2.86E-3 2 cell movement of hairy leukemia cells 0.00286 2 CD44*, IL8* deformability 2.86E-3 - 2.86E-3 2 deformability of neutrophils 0.00286 2 IL8*, TNF Cell Signaling 2.33E-5 - 2.20E-3 61 mobilization 2.33E-5 - 2.33E-5 30 ADORA2A, ANXA1, BMX, CAMP, CCL3, CCL4, CCR1*, CLECSF5, CXCL16, EDN1, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FPR1, 0.0000233 30 FPRL1*, IL8*, IL8RA, LIR9, LYN, PIK3AP1, PLAUR*, PTCRA, mobilization of calcium PTPNS1*, PTPRC, PTPRJ, SELL, SH3BP5*, TNF, TNFRSF6 production 2.68E-5 - 2.68E-5 13 production of nitric ARG1, G6PD, IL1A, IL1B*, IL1R2*, IL1RN*, PTPNS1*, SOCS3*, oxide 0.0000268 13 SOD2*, TLR4*, TLR6, TNF, TNFAIP3*

tyrosine phosphorylation 2.76E-4 - 2.76E-4 19 ADM, CCL4, CCR1*, CD44*, DAF*, EFNA1, FCER1G, FCGR2A*, 0.000276 19 HIP1*, IGF1R, ITGAM*, LYN, OSM*, PRKCD, PSEN1, PTPRC, tyrosine phosphorylation SELL, TNF, TNFRSF6 formation 3.88E-4 - 3.88E-4 5 formation of nitric oxide 0.000388 5 IL1A, IL1B*, PRKCD, TLR4*, TNF quantity 2.20E-3 - 2.20E-3 29 ADM, CCL20, CCL3, CCL4, CCR1*, CD59*, CXCL2*, EDN1, ENTPD1*, FCER1G, FCGR2A*, FPR1, GPR132, HGF, ICAM1, IL1B*, 0.0022 29 IL8*, IL8RA, ITGAM*, LYN, PLAU*, PLAUR*, PSEN1, PTPRC, quantity of calcium PTPRJ, SPINT2, TFEC*, TNF, TNFRSF6 Vitamin and Mineral Metabol 2.33E-5 - 2.20E-3 44 mobilization 2.33E-5 - 2.33E-5 30 ADORA2A, ANXA1, BMX, CAMP, CCL3, CCL4, CCR1*, CLECSF5, CXCL16, EDN1, FCER1G, FCGR1A*, FCGR2A*, FCGR2B*, FPR1, 0.0000233 30 FPRL1*, IL8*, IL8RA, LIR9, LYN, PIK3AP1, PLAUR*, PTCRA, mobilization of calcium PTPNS1*, PTPRC, PTPRJ, SELL, SH3BP5*, TNF, TNFRSF6 quantity 2.20E-3 - 2.20E-3 29 ADM, CCL20, CCL3, CCL4, CCR1*, CD59*, CXCL2*, EDN1, ENTPD1*, FCER1G, FCGR2A*, FPR1, GPR132, HGF, ICAM1, IL1B*, 0.0022 29 IL8*, IL8RA, ITGAM*, LYN, PLAU*, PLAUR*, PSEN1, PTPRC, quantity of calcium PTPRJ, SPINT2, TFEC*, TNF, TNFRSF6 Small Molecule Biochemistry2.68E-5 - 2.70E-3 14 production 2.68E-5 - 2.68E-5 13 production of nitric ARG1, G6PD, IL1A, IL1B*, IL1R2*, IL1RN*, PTPNS1*, SOCS3*, oxide 0.0000268 13 SOD2*, TLR4*, TLR6, TNF, TNFAIP3* formation 3.88E-4 - 3.88E-4 5 formation of nitric oxide 0.000388 5 IL1A, IL1B*, PRKCD, TLR4*, TNF accumulation 2.70E-3 - 2.70E-3 3 accumulation of nitrite 0.0027 3 IL1B*, IL1RN*, TNF Metabolic Disease 5.28E-5 - 5.28E-5 9 insulin-dependent diabetes mellitus 5.28E-5 - 5.28E-5 9 insulin-dependent CCL3, ICAM1, IFNGR1, IFNGR2, IGHG1*, IL1A, TAP2, TNF, diabetes mellitus 0.0000528 9 TNFRSF6 Carbohydrate Metabolism 8.40E-5 - 1.81E-3 17 uptake 8.40E-5 - 1.18E-3 13 uptake of EDN1, FPR1, HIF1A, IGF1R, IL1B*, IL8*, NTRK3, PIK3CG, PLAU*, monosaccharide 0.000084 13 PLAUR*, PTEN, SLC2A3*, TNF HIF1A, IGF1R, IL1B*, NTRK3, PIK3CG, PLAU*, PLAUR*, SLC2A3*, uptake of D-Glucose 0.00118 9 TNF transport 1.81E-3 - 1.81E-3 9 transport of monosaccharide 0.00181 9 AQP9, EDN1, IL1B*, LYN, PRKCD, PRKCG, PTEN, SLC2A3*, TNF Cardiovascular System Deve1.01E-4 - 2.86E-3 16 formation 1.01E-4 - 1.01E-4 8 formation of endothelial tube 0.000101 8 BPI, CD44*, IL8*, PLAU*, PLAUR*, PRKCD, PTEN, TNF adhesion 1.83E-4 - 1.83E-4 10 adhesion of endothelial cells 0.000183 10 CCL3, CCL4, HGF, ICAM1, IL1A, IL1B*, IL8*, SELL, TNF, TXN* pressure 5.87E-4 - 5.87E-4 3 pressure of heart ventricle 0.000587 3 PLAU*, PLAUR*, TNF angiogenesis 2.86E-3 - 2.86E-3 2 angiogenesis of peritoneum 0.00286 2 IL1B*, TNF Protein Trafficking 1.12E-4 - 1.12E-4 4 translocation 1.12E-4 - 1.12E-4 4 translocation of protein 0.000112 4 CDA, KPNB1, SOD2*, TNF Organ Morphology 1.15E-4 - 2.86E-3 12 morphology 1.15E-4 - 1.32E-3 10 morphology of lymphoid organ 0.000115 6 BCL3*, IGHG1*, NFKB2*, STAT3, TNF, TNFSF13B* morphology of spleen 0.000388 5 BCL3*, IGHG1*, NFKB2*, TNF, TNFSF13B* morphology of liver 0.00132 4 HGF, STAT5A, STAT5B*, TNFRSF6 involution 2.86E-3 - 2.86E-3 2 involution of hair follicle 0.00286 2 PLAU*, PLAUR* Tumor Morphology 1.18E-4 - 2.70E-3 26 growth 1.18E-4 - 1.18E-4 16 CASP1*, CD44*, CD59*, CREBBP, HGF, HIF1A, IGFBP5, IGHG1*, growth of tumor 0.000118 16 MMP9, PLAU*, PTEN, STAT3, STAT5B*, TNF, TNFRSF6, TXN* development 1.28E-3 - 1.28E-3 13 CEACAM1*, HGF, HIF1A, IER3, MMP9, PML*, PTCRA, PTEN, development of tumor 0.00128 13 PTPRC, TBX2, TCF3*, TGFA, TNFRSF6 adhesion 2.70E-3 - 2.70E-3 3 adhesion of leukemia cells 0.0027 3 CD44*, ICAM1, SELL Amino Acid Metabolism 1.53E-4 - 2.86E-3 4 release 1.53E-4 - 1.53E-4 3 release of cysteine 0.000153 3 IL1B*, IL1RN*, TNF quantity 2.86E-3 - 2.86E-3 2 quantity of branched chain amino acids 0.00286 2 ARG1, TNF Molecular Transport 1.53E-4 - 1.53E-4 3 release 1.53E-4 - 1.53E-4 3 release of cysteine 0.000153 3 IL1B*, IL1RN*, TNF Skeletal and Muscular Syste 1.53E-4 - 3.94E-3 23 induction 1.53E-4 - 2.86E-3 4 induction of chondrocytes 0.000153 3 BMP2, IL1B*, TNF induction of osteocytes 0.00286 2 EDN1, TNF thickness 1.53E-4 - 1.53E-4 3 thickness of trabecular bone 0.000153 3 GSN, IGFBP5, NPY2R stimulation 2.50E-4 - 3.94E-3 7 stimulation of synovial cells 0.00025 4 IL1A, IL1B*, OSM*, TNF stimulation of osteocytes 0.000479 4 EDN1, IL1A, PLAU*, TNF stimulation of osteoblasts 0.00286 2 EDN1, PLAU* stimulation of muscle cells 0.00394 4 EDN1, IL1B*, IL8*, TNF quantity 8.17E-4 - 1.26E-3 7 quantity of osteoclasts 0.000817 6 GGT1, IL1A, IL1RN*, KL, SPP1, TNF quantity of osteocytes 0.00126 7 GGT1, IL1A, IL1RN*, KL, NFKB2*, SPP1, TNF osteoclastogenesis 1.53E-3 - 1.53E-3 7 osteoclastogenesis 0.00153 7 IFNGR1, IL1A, IL1B*, NFKB2*, NFKBIA*, OSM*, TNF activation 1.69E-3 - 2.86E-3 7 activation of osteocytes 0.00169 6 GGT1, IGHG1*, IL1A, IL1RN*, NPY2R, TNF activation of cartilage tissue 0.00286 2 IL1A, IL1B* resorption 2.60E-3 - 2.60E-3 7 resorption of bone 0.0026 7 GGT1, GSN, IL1A, KL, OSM*, SPP1, TNF remodeling 3.55E-3 - 3.55E-3 13 ALPL, BMP2, BMPR2, GGT1, GSN, IL1A, KL, MMP9, NPY2R, OSM*, remodeling of bone 0.00355 13 SPP1, THRA, TNF Endocrine System Disorders 1.70E-4 - 2.61E-4 15 cell death 1.70E-4 - 2.61E-4 15 cell death of pancreatic cancer cell lines 0.00017 6 HGF, IGF1R, IL1B*, SOCS3*, TNF, TNFRSF6 cell death of pheochromocytoma cell 0.000261 10 ADORA2A, ATF3, BTG2*, CASP1*, G6PD, IL1B*, IL1RN*, MAPK14*, lines NFKBIA*, SOD2* Cell Cycle 2.50E-4 - 2.86E-3 23 mitogenesis 2.50E-4 - 2.30E-3 15 mitogenesis of liver cells 0.00025 4 HGF, REN, TGFA, TNF mitogenesis of hepatocytes 0.000587 3 HGF, TGFA, TNF ADM, CEACAM1*, EDN1, HGF, IGFBP5, IGHG1*, IL1B*, JAK2*, mitogenesis 0.0023 15 NTRK3, OSM*, REN, SPP1, TGFA, TNF, TXN* G0/G1 transition 6.21E-4 - 2.70E-3 8 arrest in G0/G1 transition 0.000621 8 CD44*, HGF, IL1B*, PLAUR*, PRKCD, PRKR, PTEN, TNF arrest in G0/G1 transition of tumor cell 0.00115 5 lines HGF, IL1B*, PLAUR*, PTEN, TNF arrest in G0/G1 transition of brain 0.00141 3 cancer cell lines HGF, PLAUR*, PTEN arrest in G0/G1 transition of nervous 0.0027 3 tissue cell lines HGF, PLAUR*, PTEN G1/S transition 1.41E-3 - 1.41E-3 3

G1/S transition of 0.00141 3 nervous tissue cell lines HGF, IGF1R, MAD* G1 phase 2.86E-3 - 2.86E-3 2 arrest in G1 phase of prostate cancer cell 0.00286 2 lines CREM*, PTEN arrest in G1 phase of prostate cell lines 0.00286 2 CREM*, PTEN Hepatic System Disease 2.50E-4 - 2.86E-3 9 stimulation 2.50E-4 - 2.50E-4 4 stimulation of hepatoma cell lines 0.00025 4 HGF, IL1A, IL1B*, TNF inflammation 2.85E-3 - 2.85E-3 4 inflammation of liver 0.00285 4 CCL3, CXCL2*, SOD2*, TNFRSF6 cell death 2.86E-3 - 2.86E-3 2 cell death of HC cells 0.00286 2 IER3, TNF Hair and Skin Development a3.26E-4 - 2.86E-3 16 adhesion 3.26E-4 - 3.26E-4 7 adhesion of epithelial cell lines 0.000326 7 ANXA1, HGF, IGF1R, ITGAM*, LGALS8*, PLAU*, PLAUR* growth 1.30E-3 - 1.30E-3 12 growth of epithelial cell BMX, HGF, IGF1R, IL1B*, JAK2*, OSM*, PLAU*, PRKCD, PTEN, lines 0.0013 12 TGFA, TNF, TXN* involution 2.86E-3 - 2.86E-3 2 involution of hair follicle 0.00286 2 PLAU*, PLAUR* Renal and Urological Diseas 3.36E-4 - 1.32E-3 15 nephritis 3.36E-4 - 3.36E-4 8 CCR1*, FCGR2B*, IFNGR1, LYN, NFKBIA*, PTPRC, TNFRSF6, nephritis 0.000336 8 TNFSF13B* renal disease 4.51E-4 - 4.51E-4 11 ADM, CCR1*, FCGR2B*, IFNGR1, LYN, NFKBIA*, PTPRC, TNF, renal disease 0.000451 11 TNFRSF6, TNFSF13B*, TRPM6* glomerulonephritis 5.35E-4 - 5.35E-4 7

glomerulonephritis 0.000535 7 CCR1*, FCGR2B*, IFNGR1, LYN, NFKBIA*, TNFRSF6, TNFSF13B* damage 8.38E-4 - 8.38E-4 7 damage of kidney 0.000838 7 ADM, FCGR1A*, FGR, KL, REN, TNF, TNFRSF6 lupus nephritis 1.32E-3 - 1.32E-3 4 lupus nephritis 0.00132 4 FCGR2B*, LYN, PTPRC, TNFRSF6 Nervous System Developme 4.79E-4 - 2.86E-3 6 growth 4.79E-4 - 2.70E-3 4 growth of brain cells 0.000479 4 IL1A, IL1B*, IL1RN*, NTN2L growth of pituitary cells 0.0027 3 IL1A, IL1B*, IL1RN* activation 2.86E-3 - 2.86E-3 2 activation of nervous tissue cell lines 0.00286 2 LY96, TNF Genetic Disorder 5.87E-4 - 5.87E-4 3 chronic granulomatous disease 5.87E-4 - 5.87E-4 3 chronic granulomatous disease 0.000587 3 CYBA, CYBB*, NCF1* Hepatic System Developmen5.87E-4 - 2.86E-3 7 mitogenesis 5.87E-4 - 5.87E-4 3 mitogenesis of hepatocytes 0.000587 3 HGF, TGFA, TNF morphology 1.32E-3 - 1.32E-3 4 morphology of liver 0.00132 4 HGF, STAT5A, STAT5B*, TNFRSF6 growth 2.86E-3 - 2.86E-3 2 growth of hepatic stellate cells 0.00286 2 EDN1, TNF Skeletal and Muscular Disord5.87E-4 - 2.86E-3 6 erosion 5.87E-4 - 2.86E-3 3 erosion of joint 0.000587 3 IL1A, IL1B*, IL1RN* erosion of ankle joint 0.00286 2 IL1A, IL1B* destabilization 8.25E-4 - 8.25E-4 4 destabilization of cartilage tissue 0.000825 4 IL1A, IL1B*, IL8*, OSM* destruction 2.70E-3 - 2.86E-3 5 destruction of cartilage tissue 0.0027 3 IL1A, IL1B*, OSM* destruction of synovial membrane 0.00286 2 IL8*, NFKBIA* hyperplasia 2.86E-3 - 2.86E-3 2 hyperplasia of synovial joint 0.00286 2 IL1B*, OSM* Viral Function 5.87E-4 - 2.86E-3 11 replication 5.87E-4 - 2.21E-3 10 replication of Human herpesvirus 5 0.000587 3 CIG5, IL1B*, TNF replication of Herpesviridae 0.00132 4 CIG5, CXCL2*, IL1B*, TNF CCL3, CCL4, CIG5, CXCL2*, IL1B*, NFKBIA*, PRKR, PTPRC, replication of virus 0.00221 10 S100A12, TNF quantity 2.86E-3 - 2.86E-3 2 quantity of Pneumonia virus of mice 0.00286 2 CCL3, CCR1*