Chlorinated Pharmaceuticals Created by the Njardarson Group (The University of Arizona): Brandon R. Smith, Candice M. Eastman, Jón T. Njarðarson
Calcium Chloride Potassium Chloride Chloromycetin pHisoHex Tace Chlor-Trimeton Clonidine Ethchlorvynol Phenoxybenzamine Nesacaine Ambenonium Halothane Atarax Compazine Leukeran Diuril Thorazine Trilafon Diabinese Chlorprothixene Parafon Vancocin ( Calcium Chloride ) ( Potassium Chloride ) ( Chloramphenicol ) ( Hexachlorophene ) ( Chlorotrianisene ) ( Chlorpheniramine & Pseudoephedrine ) ( Clonidine ) ( Ethchlorvynol ) ( Phenoxybenzamine ) ( Chloroprocaine ) ( Ambenonium ) ( Halothane ) ( Hydroxyzine ) ( Prochlorperazine ) ( Chlorambucil ) ( Chlorothiazide ) ( Chlorpromazine ) ( Perphenazine ) ( Chlorpropamide ) ( Chlorprothixene ) ( Chlorzoxazone ) ( Vancomycin )
ALM*, BBO, GUS ALM*, BBO AIN*, DER, GUS, SEN DERMATOLOGICAL GENITO-URINARY & SEX HORMONE NER, RES NER*, CAR, SEN NERVOUS SYSTEM CARDIOVASCULAR NERVOUS SYSTEM NERVOUS SYSTEM NERVOUS SYSTEM NERVOUS SYSTEM NERVOUS SYSTEM ONCOLOGICAL CARDIOVASCULAR NERVOUS SYSTEM NERVOUS SYSTEM ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM MUSCULO-SKELETAL ANTI-INFECTIVE Approved 1900s Approved 1920s Approved 1949 Approved 1949 Approved 1950 Approved 1950 Approved 1950 Approved 1950 Approved 1953 Approved 1955 Approved 1956 Approved 1956 Approved 1956 Approved 1956 Approved 1957 Approved 1957 Approved 1957 Approved 1957 Approved 1958 Approved 1958 Approved 1958 Approved 1958
Cytoxan Hydrochlorothiazide Librium Trancopal Clomifene Clomipramine Doburil Declomycin Methoxyflurane Enduron Chlorhexidine Daranide Grisactin Aldoril Valium Alkeran Triavil Maolate Serax Dyazide Clomocycline Enflurane ( Cyclophosphamide ) ( Hydrochlorothiazide ) ( Chlordiazepoxide ) ( Chlormezanone ) ( Clomifene ) ( Clomipramine ) ( Cyclothiazide ) ( Demeclocycline ) ( Methoxyflurane ) ( Methyclothiazide ) ( Chlorhexidine ) ( Dichlorphenamide ) ( Griseofulvin ) ( Methyldopa & Hydrochlorothiazide ) ( Diazepam ) ( Melphalan ) ( Amitriptyline & Perphenazine ) ( Chlorphenesin ) ( Oxazepam ) ( Triamterene & Hydrochlorothiazide ) ( Clomocycline ) ( Enflurane )
ONCOLOGICAL CAR*, END NERVOUS SYSTEM MUSCULO-SKELETAL GENITO-URINARY & SEX HORMONE NER*, END CARDIOVASCULAR AIN, DER NERVOUS SYSTEM CARDIOVASCULAR SEN*, ALM, BBO, DER, RES SENSORY ORGAN DERMATOLOGICAL CARDIOVASCULAR NERVOUS SYSTEM ONCOLOGICAL NERVOUS SYSTEM DERMATOLOGICAL NERVOUS SYSTEM CARDIOVASCULAR ANTI-INFECTIVE NERVOUS SYSTEM Approved 1959 Approved 1959 Approved 1960 Approved 1960 Approved 1960 Approved 1960 Approved 1960 Approved 1960 Approved 1960 Approved 1960 Approved 1960s Approved 1960s Approved 1962 Approved 1962 Approved 1963 Approved 1964 Approved 1965 Approved 1965 Approved 1965 Approved 1965 Approved 1966 Approved 1966
Lasix Atromid-S Haldol Pathocil Cleocin Floxapen Dalmane Ketalar Lysodren Tranxene Hyperstat Sanorex Cloxapen Monistat 7 Klonopin Lotrimin Loxitane Vanceril CeeNU Imodium Limbitrol DS Lioresal ( Furosemide ) ( Clofibrate ) ( Haloperidol ) ( Dicloxacillin ) ( Clindamycin ) ( Flucloxacillin ) ( Flurazepam ) ( Ketamine ) ( Mitotane ) ( Clorazepate ) ( Diazoxide ) ( Mazindol ) ( Cloxacillin ) ( Miconazole ) ( Clonazepam ) ( Clotrimazole ) ( Loxapine ) ( Beclomethasone ) ( Lomustine ) ( Loperamide ) ( Amitriptyline & Chlordiazepoxide ) ( Baclofen )
CARDIOVASCULAR BBO, CAR NERVOUS SYSTEM ANTI-INFECTIVE AIN, DER, GUS ANTI-INFECTIVE NERVOUS SYSTEM NERVOUS SYSTEM ONCOLOGICAL NERVOUS SYSTEM CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM ANTI-INFECTIVE AIN*, ALM, DER, GUS, SEN NERVOUS SYSTEM ALM*, GUS*, DER NERVOUS SYSTEM ALM, DER, RES ONCOLOGICAL ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM MUSCULO-SKELETAL Approved 1966 Approved 1967 Approved 1967 Approved 1968 Approved 1970 Approved 1970 Approved 1970 Approved 1970 Approved 1970 Approved 1972 Approved 1973 Approved 1973 Approved 1974 Approved 1974 Approved 1975 Approved 1975 Approved 1975 Approved 1976 Approved 1976 Approved 1976 Approved 1977 Approved 1977
BiCNU Tavist Cloderm Ativan Platinol Aldactazide Buclizine Ceclor Forane Reglan Inderide Adinazolam Asendin Halotex Meclomen Domperidone Xanax Moduretic Midamor Emcyt Paxipam Nizoral ( Carmustine ) ( Clemastine ) ( Clocortolone ) ( Lorazepam ) ( Cisplatin ) ( Spironolactone & Hydrochlorothiazide ) ( Buclizine ) ( Cefaclor ) ( Isoflurane ) ( Metoclopramide ) ( Propranolol & Hydrochlorothiazide ) ( Adinazolam ) ( Amoxapine ) ( Haloprogin ) ( Meclofenamate ) ( Domperidone ) ( Alprazolam ) ( Amiloride & Hydrochlorothiazide ) ( Amiloride ) ( Estramustine ) ( Halazepam ) ( Ketoconazole )
ONCOLOGICAL RES*, NER DERMATOLOGICAL NERVOUS SYSTEM ONCOLOGICAL CARDIOVASCULAR RESPIRATORY SYSTEM ANTI-INFECTIVE NERVOUS SYSTEM ALIMENTARY TRACT & METABOLISM CARDIOVASCULAR NERVOUS SYSTEM NERVOUS SYSTEM DERMATOLOGICAL MUSCULO-SKELETAL ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM CARDIOVASCULAR CARDIOVASCULAR ONCOLOGICAL NERVOUS SYSTEM AIN, DER, GUS Approved 1977 Approved 1977 Approved 1977 Approved 1977 Approved 1978 Approved 1978 Approved 1979 Approved 1979 Approved 1979 Approved 1979 Approved 1979 Approved 1980 Approved 1980 Approved 1980 Approved 1980 Approved 1980s (CAN) Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1981
Restoril Aclovate Spectazole Halcion Lozol TZ-3 Tenoretic Lotrisone Capozide Lopressor HCT Wellbutrin Femstat Temovate Versed Progabide Lamprene Vaseretic Tenex Trazodone Zopiclone Iopidine Tussicaps ( Temazepam ) ( Alclometasone ) ( Econazole ) ( Triazolam ) ( Indapamide ) ( Tioconazole ) ( Atenolol & Chlorthalidone ) ( Betamethasone Dipropionate & Clotrimazole ) ( Captopril & Hydrochlorothiazide ) ( Metoprolol & Hydrochlorothiazide ) ( Bupropion ) ( Butoconazole ) ( Clobetasol ) ( Midazolam ) ( Progabide ) ( Clofazimine ) ( Enalapril & Hydrochlorothiazide ) ( Guanfacine ) ( Trazodone ) ( Zopiclone ) ( Apraclonidine ) ( Chlorpheniramine & Hydrocodone )
NERVOUS SYSTEM DER, SEN DER, GUS NERVOUS SYSTEM CARDIOVASCULAR DER, GUS CARDIOVASCULAR DERMATOLOGICAL CAR*, END CARDIOVASCULAR NERVOUS SYSTEM GENITO-URINARY & SEX HORMONE DERMATOLOGICAL NERVOUS SYSTEM NERVOUS SYSTEM ANTI-INFECTIVE CARDIOVASCULAR CARDIOVASCULAR NER*, END NERVOUS SYSTEM SENSORY ORGAN NERVOUS SYSTEM Approved 1981 Approved 1982 Approved 1982 Approved 1982 Approved 1983 Approved 1983 Approved 1984 Approved 1984 Approved 1984 Approved 1984 Approved 1985 Approved 1985 Approved 1985 Approved 1985 Approved 1985 Approved 1986 Approved 1986 Approved 1986 Approved 1986 Approved 1986 Approved 1987 Approved 1987
Mykrox Elocon Terazol 7 Voltaren Ifex Oxistat Metahydrin Clozaril Prinzide Prosom Moclobemide Plendil Lorabid Zoloft Tilid Lotensin HCT Sporanox Ziac Propulsid Leustatin Lipidil Claritin ( Metolazone ) ( Mometasone ) ( Terconazole ) ( Diclofenac ) ( Ifosfamide ) ( Oxiconazole ) ( Trichlormethiazide ) ( Clozapine ) ( Lisinopril & Hydrochlorothiazide ) ( Estazolam ) ( Moclobemide ) ( Felodipine ) ( Loracarbef ) ( Sertraline ) ( Ticlopidine ) ( Benazepril & Hydrochlorothiazide ) ( Itraconazole ) ( Bisoprolol & Hydrochlorothiazide ) ( Cisapride ) ( Cladribine ) ( Fenofibrate ) ( Loratadine )
CARDIOVASCULAR DER, RES GENITO-URINARY & SEX HORMONE MSK, SEN ONCOLOGICAL DER, GUS CARDIOVASCULAR NERVOUS SYSTEM CARDIOVASCULAR NERVOUS SYSTEM NERVOUS SYSTEM CARDIOVASCULAR ANTI-INFECTIVE NER, GUS BLOOD & BLOOD FORMING ORGAN CARDIOVASCULAR AIN*, GUS CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM ONCOLOGICAL BBO*, CAR*, END RESPIRATORY SYSTEM Approved 1987 Approved 1987 Approved 1987 Approved 1988 Approved 1988 Approved 1988 Approved 1988 Approved 1989 Approved 1989 Approved 1990 Approved 1990 Approved 1991 Approved 1991 Approved 1991 Approved 1991 Approved 1992 Approved 1992 Approved 1993 Approved 1993 Approved 1993 Approved 1993 Approved 1993
Monopril-HCT Lamictal Claritin-D Serzone Lotrel Zyrtec Hyzaar Cozaar Astelin Lexxel Zanaflex Agrylin Plavix Arthrotec Corlopam Glyburide Avalide Meridia Fareston Sustiva Lotemax Singulair ( Fosinopril & Hydrochlorothiazide ) ( Lamotrigine ) ( Loratadine & Pseudoephedrine ) ( Nefazodone ) ( Amlodipine & Benazepril ) ( Cetirizine ) ( Losartan & Hydrochlorothiazide ) ( Losartan ) ( Azelastine ) ( Enalapril & Felodipine ) ( Tizanidine ) ( Anagrelide ) ( Clopidogrel ) ( Diclofenac & Misoprostol ) ( Fenoldopam ) ( Glibenclamide ) ( Irbesartan & Hydrochlorothiazide ) ( Sibutramine ) ( Toremifene ) ( Efavirenz ) ( Loteprednol Etabonate ) ( Montelukast )
CARDIOVASCULAR NERVOUS SYSTEM NERVOUS SYSTEM NERVOUS SYSTEM CARDIOVASCULAR RESPIRATORY SYSTEM CARDIOVASCULAR CARDIOVASCULAR RES*, SEN CAR*, END MUSCULO-SKELETAL BBO, ONC BBO*, END*, CAR ALIMENTARY TRACT & METABOLISM CARDIOVASCULAR BBO, END CARDIOVASCULAR ALM, END END, ONC ANTI-INFECTIVE SENSORY ORGAN RESPIRATORY SYSTEM Approved 1994 Approved 1994 Approved 1994 Approved 1994 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1996 Approved 1996 Approved 1996 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1998 Approved 1998 Approved 1998
Diovan HCT Norvasc Accuretic Benzaclin Atacand HCT Cetrotide Glucovance Micardis HCT Zyrtec-D Clarinex D 24 Hour Clarinex Teveten HCT Elidel Geodon Abilify Plenaxis Carbinoxamine Iressa Benicar HCT Ertaczo Caduet Advil A.S. ( Valsartan & Hydrochlorothiazide ) ( Amlodipine ) ( Quinapril & Hydrochlorothiazide ) ( Benzoyl Peroxide & Clindamycin ) ( Candesartan & Hydrochlorothiazide ) ( Cetrorelix ) ( Glyburide & Metformin ) ( Telmisartan & Hydrochlorothiazide ) ( Cetirizine & Pseudoephedrine ) ( Desloratadine & Pseudoephedrine ) ( Desloratadine ) ( Eprosartan & Hydrochlorothiazide ) ( Pimecrolimus ) ( Ziprasidone ) ( Aripiprazole ) ( Abarelix ) ( Carbinoxamine ) ( Gefitinib ) ( Olmesartan & Hydrochlorothiazide ) ( Sertaconazole ) ( Amlodipine & Atorvastatin ) ( Chlorpheniramine, Pseudoephedrine & Ibuprofen )
CARDIOVASCULAR CARDIOVASCULAR CARDIOVASCULAR DERMATOLOGICAL CARDIOVASCULAR GENITO-URINARY & SEX HORMONE ALIMENTARY TRACT & METABOLISM CAR, END NERVOUS SYSTEM RESPIRATORY SYSTEM RESPIRATORY SYSTEM CARDIOVASCULAR DERMATOLOGICAL NERVOUS SYSTEM NERVOUS SYSTEM GUS, ONC RESPIRATORY SYSTEM ONC, RES CARDIOVASCULAR DERMATOLOGICAL BBO, CAR NERVOUS SYSTEM Approved 1998 Approved 1999 Approved 1999 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2002 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2004 Approved 2004
Clolar Lunesta Zylet Nexavar Ziana Sprycel Atripla AZOR Exforge Fenofibric Acid Tykerb Xyzal Tekturna HCT Treanda Cleviprex Degarelix Saphris Bepreve Besivance Zipsor Vibativ Samsca ( Clofarabine ) ( Eszopiclone ) ( Loteprednol Etabonate & Tobramycin ) ( Sorafenib ) ( Clindamycin & Tretinoin ) ( Dasatinib ) ( Emtricitabine, Tenofovir Disoproxil & Efavirenz ) ( Amlodipine & Olmesartan ) ( Amlodipine & Valsartan ) ( Fenofibric Acid ) ( Lapatinib ) ( Levocetirizine ) ( Aliskiren & Hydrochlorothiazide ) ( Bendamustine ) ( Clevidipine ) ( Degarelix ) ( Asenapine ) ( Bepotastine ) ( Besifloxacin ) ( Diclofenac ) ( Telavancin ) ( Tolvaptan )
ONCOLOGICAL NERVOUS SYSTEM SENSORY ORGAN ALM, ONC DERMATOLOGICAL ONCOLOGICAL ANTI-INFECTIVE CARDIOVASCULAR CARDIOVASCULAR CARDIOVASCULAR ONCOLOGICAL DER, RES CARDIOVASCULAR ONCOLOGICAL CARDIOVASCULAR GUS, ONC NERVOUS SYSTEM SENSORY ORGAN ANTI-INFECTIVE NERVOUS SYSTEM AIN, DER BLOOD & BLOOD FORMING ORGAN Approved 2004 Approved 2004 Approved 2004 Approved 2005 Approved 2006 Approved 2006 Approved 2006 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2008 Approved 2008 Approved 2008 Approved 2008 Approved 2009 Approved 2009 Approved 2009 Approved 2009 Approved 2009 Approved 2009 Tekamlo Amturnide Dulera Tribenzor Onfi Xalkori Dificid Xarelto Daliresp Zelboraf Stendra Dymista Bosulif Stribild Belviq Stivarga Erivedge BEP BEACOPP CHOP CMF CVP
( Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, ( Olmesartan Medoxomil, Amlopidine & Hydrochlorothiazide ) ( Cobicistat, Elvitegravir, Emtricitabine & Tenofovir Disoproxil ) ( Cyclophosphamide, Doxorubicin, Vincristine & Prednisone ) ( Cyclophosphamide, Methotrexate & Fluorouracil ) ( Cyclophosphamide, Vincristine, & Prednisone ) ( Aliskiren & Amlodipine ) ( Aliskiren, Amlopidine & Hydrochlorothiazide ) ( Mometasone & Formoterol ) ( Clobazam ) ( Crizotinib ) ( Fidaxomicin ) ( Rivaroxaban ) ( Roflumilast ) ( Vemurafenib ) ( Avanafil ) ( Azelastine & Fluticasone ) ( Bosutinib ) ( Lorcaserin ) ( Regorafenib ) ( Vismodegib ) ( Bleomycin, Etoposide & Cisplatin ) Procarbazine & Prednisone )
CARDIOVASCULAR CARDIOVASCULAR RESPIRATORY SYSTEM CARDIOVASCULAR NERVOUS SYSTEM ONC, RES AIN, ALM BBO, CAR RESPIRATORY SYSTEM DER, ONC GUS, MSK RESPIRATORY SYSTEM BBO, ONC ANTI-INFECTIVE ENDOCRINE SYSTEM ALM, ONC DER, ONC ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL Approved 2010 Approved 2010 Approved 2010 Approved 2010 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+
C-VAMP COPP AC ABVE-PC AC-T EPOCH Gemcitabine-Cisplatin ICE Stanford V MOPP R-CHOP R-CVP VeIP CATEGORY ABBREVIATIONS
( Doxorubicin, Bleomycin, Vincristine, Etoposide, Prednisone & ( Mechlorethamine, Doxorubicin, Vinblastine, Vincristine, Bleomycin, ( Cyclophosphamide, Vincristine, Doxorubicin & Methylprednisolone ) ( Cyclophosphamide, Vincristine, Procarbazine & Prednisone ) ( Doxorubicin, Cyclophosphamide & Paclitaxel ) ( Etoposide, Prednisone, Vincristine, Cyclophosphamide & Doxorubicin ) ( Mechloroethamine, Vincristine, Prednisone & Procarbazine ) ( Rituximab, Cyclophosphamide, Doxorubicin, Vincristine & Prednisone ) ( Rituximab, Cyclophosphamide, Vincristine & Prednisone ) ( Doxorubicin & Cyclophosphamide ) Cyclophosphamide ) ( Gemcitabine & Cisplatin ) ( Ifosfamide, Carboplatin & Etoposide ) Etoposide & Prednisone ) ( Vinblastine, Ifosfamide, Cisplatin, & Mesna ) ALM ALIMENTARY TRACT & METABOLISM
AIN ANTI-INFECTIVE
BBO BLOOD & BLOOD FORMING ORGANS
CAR CARDIOVASCULAR SYSTEM
DER DERMATOLOGICAL
END ENDOCRINE SYSTEM
GUS GENITO-URINARY & SEX HORMONES
MSK MUSCULO-SKELETAL SYSTEM
NER NERVOUS SYSTEM ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONC ONCOLOGICAL
Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ RES RESPIRATORY SYSTEM
SEN SENSORY ORGANS All drugs are considered FDA approved in the U.S. following the passage of the Pure Food and Drugs Act in 1906. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ * The FDA approval year and Market Name is representative of the first three-letter abbreviation of the disease category (see legend) in the series. + This drug has also been FDA approved for additional disorders. ` According to the National Cancer Institute (http://www.cancer.gov), chemotherapy regimens do not have an official FDA approval, however, each individual molecular component is FDA approved.